PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16667156-3	1989	Chalcone synthase (CHS) is the first enzyme of the flavonoid/isoflavonoid biosynthetic pathway.	Flavonoids	51-60	chalcone synthase	Glycine max	0-17
16667156-3	1989	Chalcone synthase (CHS) is the first enzyme of the flavonoid/isoflavonoid biosynthetic pathway.	Flavonoids	51-60	chalcone synthase	Glycine max	19-22
2792072-2	1989	The transcription of PAL is regulated in response to various factors that induce the accumulation of flavonoids, lignin and compounds thought to be involved in plant defence reactions.	Flavonoids	101-111	phenylalanine ammonia-lyase	Nicotiana tabacum	21-24
2509087-0	1989	Structure-activity correlation of flavonoids for inhibition of bovine lens aldose reductase.	Flavonoids	34-44	aldose reductase	Bos taurus	75-91
2509087-1	1989	To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened.	Flavonoids	49-59	aldose reductase	Bos taurus	78-94
2509087-1	1989	To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened.	Flavonoids	49-58	aldose reductase	Bos taurus	78-94
2730676-0	1989	Protein kinase C inhibition by plant flavonoids.	Flavonoids	37-47	protein kinase C, gamma	Rattus norvegicus	0-16
2737161-1	1989	Naturally occurring and synthetic flavonoids are potent inhibitors of thyroid hormone 5"-deiodination and binding to human serum transthyretin (TTR) in vitro.	Flavonoids	34-44	transthyretin	Rattus norvegicus	129-142
2737161-1	1989	Naturally occurring and synthetic flavonoids are potent inhibitors of thyroid hormone 5"-deiodination and binding to human serum transthyretin (TTR) in vitro.	Flavonoids	34-44	transthyretin	Rattus norvegicus	144-147
2730676-2	1989	Protein kinase C (PKC) from rat brain was inhibited by plant flavonoids in a concentration-dependent manner depending on flavonoid structure.	Flavonoids	61-71	protein kinase C, gamma	Rattus norvegicus	0-16
2730676-2	1989	Protein kinase C (PKC) from rat brain was inhibited by plant flavonoids in a concentration-dependent manner depending on flavonoid structure.	Flavonoids	61-71	protein kinase C, gamma	Rattus norvegicus	18-21
2730676-2	1989	Protein kinase C (PKC) from rat brain was inhibited by plant flavonoids in a concentration-dependent manner depending on flavonoid structure.	Flavonoids	61-70	protein kinase C, gamma	Rattus norvegicus	0-16
2730676-2	1989	Protein kinase C (PKC) from rat brain was inhibited by plant flavonoids in a concentration-dependent manner depending on flavonoid structure.	Flavonoids	61-70	protein kinase C, gamma	Rattus norvegicus	18-21
2730676-10	1989	Analysis of these structure-activity data revealed a model of the minimal essential features required for PKC inhibition by flavonoids: a coplanar flavone structure with free hydroxyl substituents at the 3", 4" and 7-positions.	Flavonoids	124-134	protein kinase C, gamma	Rattus norvegicus	106-109
3218613-2	1988	The interaction of retinoids and flavonoids with phospholipases A2 (PLA2) was studied to assess the mechanism of inhibition.	Flavonoids	33-43	phospholipase A2 group IIA	Homo sapiens	68-72
2766409-4	1989	Results obtained in this way showed that the double bond at C-2 and C-3 of the flavonoid structure is a prerequisite for anti-tumor-promoting activity, and indicated that activity in this screening assay for inhibitors of TPA-induced ear edema reflects the anti-tumor-promoting effect in two-stage carcinogenesis.	Flavonoids	79-88	complement component 2 (within H-2S)	Mus musculus	60-63
2766409-4	1989	Results obtained in this way showed that the double bond at C-2 and C-3 of the flavonoid structure is a prerequisite for anti-tumor-promoting activity, and indicated that activity in this screening assay for inhibitors of TPA-induced ear edema reflects the anti-tumor-promoting effect in two-stage carcinogenesis.	Flavonoids	79-88	complement component 3	Mus musculus	68-71
2919414-0	1989	A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain.	Flavonoids	2-11	arachidonate 5-lipoxygenase	Homo sapiens	25-39
2502444-12	1989	The content of P-450 and the activity of NADPH-cytochrome P-450 reductase were high in PB-, MC- and BNF-microsomes, whereas NADH-cytochrome b5 reductase activity was high in two flavonoid-microsomes and the content of cytochrome b5 was not changed except the PB-treated rats.	Flavonoids	178-187	cytochrome b5 type A	Rattus norvegicus	129-142
3218613-11	1988	These findings indicate that inhibition of non-pancreatic human PLA2S by retinoids and flavonoids can be mediated by interaction with enzyme and/or substrate.	Flavonoids	87-97	phospholipase A2 group IIA	Homo sapiens	64-69
3218613-5	1988	Inhibition of PLA2 activity by both flavonoid and retinoids were independent of Ca2+ or Na+.	Flavonoids	36-45	phospholipase A2 group IIA	Homo sapiens	14-18
2907559-0	1988	Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids.	Flavonoids	137-147	arachidonate 5-lipoxygenase	Rattus norvegicus	26-40
3412324-0	1988	Computer-automated structure evaluation of flavonoids and other structurally related compounds as glyoxalase I enzyme inhibitors.	Flavonoids	43-53	glyoxalase I	Homo sapiens	98-110
3164998-8	1988	Structure activity studies exhibited that the inhibitory potencies of the flavonoids for tyrosine kinases of pp130fps and insulin receptor correlated with the number of hydroxy residues on the flavone rings (gamma = 0.974 and 0.926, respectively), whereas the hydroxylation influenced to a lesser extent the inhibitory potencies for serine/threonine protein kinase.	Flavonoids	74-84	insulin receptor	Homo sapiens	122-138
3412324-1	1988	The Computer-Automated Structure Evaluation (CASE) methodology has been applied to a set of flavonoids and other structurally related compounds tested for glyoxalase I enzyme inhibition.	Flavonoids	92-102	glyoxalase I	Homo sapiens	155-167
3128297-0	1988	Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1.	Flavonoids	15-25	seed linoleate 13S-lipoxygenase-1	Glycine max	107-121
2968941-1	1988	Flavonoids (quercetin, rutin) influence ATPase activity and actomyosin superprecipitation.	Flavonoids	0-10	dynein axonemal heavy chain 8	Homo sapiens	40-46
2968941-2	1988	Low concentrations (below 20 mumol/l) of flavonoids were found to cause conformational changes in the myosin structure accompanied by an increase in ATPase activity.	Flavonoids	41-51	myosin heavy chain 14	Homo sapiens	102-108
2968941-2	1988	Low concentrations (below 20 mumol/l) of flavonoids were found to cause conformational changes in the myosin structure accompanied by an increase in ATPase activity.	Flavonoids	41-51	dynein axonemal heavy chain 8	Homo sapiens	149-155
2968941-3	1988	At higher concentrations an inhibitory action of flavonoids on both ATPase activity and actomyosin superprecipitation occurred.	Flavonoids	49-59	dynein axonemal heavy chain 8	Homo sapiens	68-74
2968941-4	1988	Conformational changes are likely to be due to flavonoids binding to regulatory site near the active centre of the myosin head.	Flavonoids	47-57	myosin heavy chain 14	Homo sapiens	115-121
3140249-4	1988	The T4-binding site of hTBPA is a useful "receptor model" for type I deiodinase in computer aided drug design of flavonoid antagonists with improved pharmacological characteristics, bio-availability, and target-specificity for ITH-binding sites.	Flavonoids	113-122	transthyretin	Homo sapiens	23-28
2894963-3	1988	In this study, we investigated the interaction of certain flavonoid components of green tea epicatechin derivatives including (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG), and (-)-epigallocatechin-3-gallate (EGCG) with rat hepatic microsomal cytochrome P-450 (P-450).	Flavonoids	58-67	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	279-295
2840292-9	1988	These findings indicate that flavonoid-induced fever may be due to allergic as well as pseudo-allergic mechanisms, the latter probably caused by increased antigen-independent release of IL-1, the endogenous mediator of fever.	Flavonoids	29-38	interleukin 1 alpha	Homo sapiens	186-190
3499481-0	1987	Flavonoids protect against T-2 mycotoxins both in vitro and in vivo.	Flavonoids	0-10	brachyury 2	Mus musculus	27-30
3678379-0	1987	The anti-invasive flavonoid (+)-catechin binds to laminin and abrogates the effect of laminin on cell morphology and adhesion.	Flavonoids	18-27	laminin, beta 2 (laminin S)	Gallus gallus	50-57
3678379-0	1987	The anti-invasive flavonoid (+)-catechin binds to laminin and abrogates the effect of laminin on cell morphology and adhesion.	Flavonoids	18-27	laminin, beta 2 (laminin S)	Gallus gallus	86-93
3678379-9	1987	We speculate that the anti-invasive activity of the flavonoid to MO4 cells is the result of its interference with MO4 cell adhesion to laminin.	Flavonoids	52-61	laminin, beta 2 (laminin S)	Gallus gallus	135-142
3149594-0	1987	[Inhibition of rat lens aldose reductase by flavonoids-matteucinol and baicalein].	Flavonoids	44-54	aldo-keto reductase family 1 member B1	Rattus norvegicus	24-40
2829870-3	1987	The increase of LPO as well as of enzyme leakage were reduced by mannitol and the flavonoid troxerutin showing antioxidative action of greater than 500 and greater than 5 microM, respectively.	Flavonoids	82-91	lactoperoxidase	Rattus norvegicus	16-19
3106941-1	1986	Twenty flavonoids isolated from plants or transformed into methyl or acetyl derivatives were tested with regard to their influence on cyclooxygenase from the ram seminal vesicle microsomes and lipoxygenase from soya beans.	Flavonoids	7-17	linoleate 9S-lipoxygenase-4	Glycine max	193-205
3107341-0	1986	[Inhibition of aldose reductase from the rat lens by flavonoids].	Flavonoids	53-63	aldo-keto reductase family 1 member B1	Rattus norvegicus	15-31
3104688-6	1986	There classes of AR inhibitors can be distinguished: flavonoids and their related compounds, spirohydantoins--like sorbinil--and related compounds, and compounds with an acid function such as alrestatine.	Flavonoids	53-63	aldo-keto reductase family 1 member B	Homo sapiens	17-19
3106941-6	1986	Structural requirements for the cyclooxygenase stimulation, lipoxygenase inhibition and antioxidant properties were different in the case of the twenty tested flavonoids.	Flavonoids	159-169	linoleate 9S-lipoxygenase-4	Glycine max	60-72
3525045-1	1986	A new synthetic flavonoid inhibiting histidine decarboxylase.	Flavonoids	16-25	histidine decarboxylase	Rattus norvegicus	37-60
3736343-1	1986	The effect of flavonoids on beta-hexosaminidase transport and endocytosis has been studied in cultured human skin fibroblasts.	Flavonoids	14-24	O-GlcNAcase	Homo sapiens	28-47
3778562-4	1986	55 flavonoid compounds were tested for their ability to interfere with CCl4-induced release of ASAT.	Flavonoids	3-12	C-C motif chemokine ligand 4	Rattus norvegicus	71-75
3525045-2	1986	Flavonoids reportedly inhibit histidine decarboxylase and reduce gastric mucosal histamine content.	Flavonoids	0-10	histidine decarboxylase	Rattus norvegicus	30-53
17342613-1	1985	Hypolaetin-8-glucoside, a flavonoid isolated from SIDERITIS MUGRONENSIS possessing anti-inflammatory activity inhibited dose-dependently the human PRP aggregation induced by ADP with a IC (50) = 2.4 x 10 (-4) M. This action does not seem to be related to cyclo-oxygenase, as this flavonoid is not an inhibitor and even is able to act as a cofactor for this enzyme.	Flavonoids	26-35	prion protein	Homo sapiens	147-150
3331657-0	1986	Genetic toxicology of flavonoids: the role of metabolic conditions in the induction of reverse mutation, SOS functions and sister-chromatid exchanges.	Flavonoids	22-32	xylosyltransferase 2	Homo sapiens	105-108
3086893-0	1986	Inhibition of aldose reductase by flavonoids: possible attenuation of diabetic complications.	Flavonoids	34-44	aldo-keto reductase family 1 member B	Homo sapiens	14-30
2425573-2	1986	The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties.	Flavonoids	105-114	formyl peptide receptor 1	Homo sapiens	28-32
3088613-0	1986	Flavonoid inhibition of soybean lipoxygenase.	Flavonoids	0-9	linoleate 9S-lipoxygenase-4	Glycine max	32-44
17342613-1	1985	Hypolaetin-8-glucoside, a flavonoid isolated from SIDERITIS MUGRONENSIS possessing anti-inflammatory activity inhibited dose-dependently the human PRP aggregation induced by ADP with a IC (50) = 2.4 x 10 (-4) M. This action does not seem to be related to cyclo-oxygenase, as this flavonoid is not an inhibitor and even is able to act as a cofactor for this enzyme.	Flavonoids	280-289	prion protein	Homo sapiens	147-150
3924112-1	1985	The effect of ten flavonoids was studied on the stimulation of washed human platelets by either arachidonic acid or thrombin.	Flavonoids	18-28	coagulation factor II, thrombin	Homo sapiens	116-124
16664081-1	1985	The viviparous-1 (vp1) mutation in maize (Zea mays L.) conditions a unique pleiotropic phenotype: premature germination of the embryo and failure to synthesize anthocyanin (flavonoid) pigments in the aleurone.	Flavonoids	173-182	regulatory protein viviparous-1	Zea mays	4-16
2988452-0	1985	Aldose reductase inhibitors: flavonoids, alkaloids, acetophenones, benzophenones, and spirohydantoins of chroman.	Flavonoids	29-39	aldo-keto reductase family 1 member B1	Oryctolagus cuniculus	0-16
16664187-4	1985	PAL and CHS activity was highest between 24 and 30 hours after treatment, isoflavone aglycones and pterocarpans at 48 hours, IGT at 72 hours, and isoflavone glucosides at 96 hours.Mesophyll cells isolated from control leaves contained no activity for PAL, CHS, or IGT and no flavonoids of any class.	Flavonoids	275-285	chalcone synthase 3	Glycine max	8-11
3925883-0	1985	Inhibition of cytochrome P-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin.	Flavonoids	91-100	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	14-30
3925883-1	1985	The kinetic characteristics and mechanism of flavonoid inhibition of cytochrome P-450-mediated reactions were examined in rat liver microsomes, using the naturally occurring flavonoid, quercetin (3,3",4",5,7-pentahydroxyflavone).	Flavonoids	45-54	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	69-85
2986975-12	1985	Quercetin, a bioflavonoid, acts as a strong inhibitor of p68 protein kinase activity.	Flavonoids	13-25	GATA zinc finger domain containing 2B	Homo sapiens	57-60
16664081-1	1985	The viviparous-1 (vp1) mutation in maize (Zea mays L.) conditions a unique pleiotropic phenotype: premature germination of the embryo and failure to synthesize anthocyanin (flavonoid) pigments in the aleurone.	Flavonoids	173-182	regulatory protein viviparous-1	Zea mays	18-21
16664081-3	1985	Anthocyaninless vp1 aleurones were found to be deficient in at least three enzymes of flavonoid biosynthesis (phenylalanine ammonia lyase, chalcone synthase, and UDPG-flavonoid glucosyltransferase) as well as in several other metabolically unrelated enzymes that show pronounced increases in late stages of aleurone development.	Flavonoids	86-95	regulatory protein viviparous-1	Zea mays	16-19
16664081-3	1985	Anthocyaninless vp1 aleurones were found to be deficient in at least three enzymes of flavonoid biosynthesis (phenylalanine ammonia lyase, chalcone synthase, and UDPG-flavonoid glucosyltransferase) as well as in several other metabolically unrelated enzymes that show pronounced increases in late stages of aleurone development.	Flavonoids	86-95	chalcone synthase	Zea mays	139-156
6568822-5	1984	In addition, the coacervation profile of kappa-elastin peptides as a function of temperature is greatly modified in presence of these flavonoids.	Flavonoids	134-144	elastin	Homo sapiens	47-54
11540853-7	1985	Other flavonoids such as epicatechin, quercetin and naringenin also inhibited calmodulin-promoted phosphodiesterase activity.	Flavonoids	6-16	calmodulin1	Zea mays	78-88
2409013-1	1985	Naturally occurring plant flavonoids, normal dietary constituents, affect a variety of cell activation phenomena including the secretion of histamine from human basophils stimulated by a variety of agents (antigen, anti-IgE, concanavalin A, ionophore A23187, formyl-Met-Leu-Phe and tetradecanoyl phorbol acetate).	Flavonoids	26-36	immunoglobulin heavy constant epsilon	Homo sapiens	220-223
6092041-3	1984	This protein kinase activity is inhibited by the bioflavonoid quercetin at doses that do not inhibit cAMP-dependent protein kinase activity.	Flavonoids	49-61	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	5-19
6096035-6	1984	Thus, the flavonoid had only a slight inhibitory effect on PB-induced AHH in C2Rev7 cells, but strongly inhibited PB-induced AHH in H5 cells.	Flavonoids	10-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	70-73
6096035-6	1984	Thus, the flavonoid had only a slight inhibitory effect on PB-induced AHH in C2Rev7 cells, but strongly inhibited PB-induced AHH in H5 cells.	Flavonoids	10-19	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	125-128
6327791-4	1984	In contrast, the release of lysosomal beta-glucuronidase from neutrophils stimulated with opsonized zymosan was only inhibited by two flavonoids, quercetin and chalcone, and only at concentrations of 1.5 X 10(-4)M to 2 X 10(-4)M. Quercetin also inhibited the generation of superoxide anion by neutrophils but to a lesser degree than its effect on CL.	Flavonoids	134-144	glucuronidase beta	Homo sapiens	38-56
6735033-0	1984	Interaction between quercetin and Ca2+-calmodulin complex: possible mechanism for anti-tumor-promoting action of the flavonoid.	Flavonoids	117-126	calmodulin 1	Homo sapiens	39-49
6418162-0	1983	Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase.	Flavonoids	0-10	arachidonate 5-lipoxygenase	Bos taurus	33-60
6427052-0	1984	Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds.	Flavonoids	11-21	ornithine decarboxylase, structural 1	Mus musculus	97-120
6427052-9	1984	Thus, the inhibitory effects of flavonoids and antioxidants on the TPA-caused ODC induction and tumor promotion were roughly parallel with their activities of lipoxygenase inhibition.	Flavonoids	32-42	ornithine decarboxylase, structural 1	Mus musculus	78-81
6429283-3	1984	Three of these flavonoids were tested and showed inhibition of rat lens aldose reductase.	Flavonoids	15-25	aldo-keto reductase family 1 member B1	Rattus norvegicus	72-88
6661236-1	1983	The flavonoid quercetin is a potent inhibitor of calcium- and phospholipid-dependent protein kinase (Ca, PL-PK) activity from mouse brain.	Flavonoids	4-13	interleukin-1 receptor-associated kinase 1	Mus musculus	105-110
6418162-1	1983	Various flavonoids were found to be relatively selective inhibitors of arachidonate 5-lipoxygenase which initiates the biosynthesis of leukotrienes with the activity of slow reacting substance of anaphylaxis.	Flavonoids	8-18	arachidonate 5-lipoxygenase	Bos taurus	71-98
6297578-9	1983	Both Ca2+ transport and Ca2+-ATPase activity were inhibited by the flavonoid quercetin.	Flavonoids	67-76	dynein axonemal heavy chain 8	Homo sapiens	29-35
6409111-0	1983	Inhibition of human lens aldose reductase by flavonoids, sulindac and indomethacin.	Flavonoids	45-55	aldo-keto reductase family 1 member B	Homo sapiens	25-41
6409111-1	1983	The inhibition of human lens aldose reductase by flavonoids has been studied.	Flavonoids	49-59	aldo-keto reductase family 1 member B	Homo sapiens	29-45
6311542-1	1983	The phosphotransferase activity of the Rous sarcoma virus src gene product, pp60src, was inhibited both in vitro and in vivo by the bioflavonoid quercetin.	Flavonoids	132-144	p60 src	Rous sarcoma virus	58-61
15595-0	1977	Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.	Flavonoids	0-12	dynein, axonemal, heavy chain 8	Mus musculus	27-33
6814912-5	1982	Flavonoids, e.g. quercetin and rutin, inhibit aldose reductase (IC50 = 2 - 5 microM).	Flavonoids	0-10	aldo-keto reductase family 1 member B	Homo sapiens	46-62
100892-5	1978	Sugar cataracts can be delayed or prevented with such aldose reductase inhibitors as flavonoids.	Flavonoids	85-95	aldo-keto reductase family 1 member B	Homo sapiens	54-70
562863-0	1977	Influence of flavonoid-copper complexes on cross linking in elastin.	Flavonoids	13-22	elastin	Mus musculus	60-67
562863-3	1977	This paper deals with the effect in vitro of flavonoids and flavonoid-copper complexes on the oxidative deamination of lysine epsilon-amino groups in [4,5-3H]-lysine-labelled elastin.	Flavonoids	45-55	elastin	Mus musculus	175-182
562863-3	1977	This paper deals with the effect in vitro of flavonoids and flavonoid-copper complexes on the oxidative deamination of lysine epsilon-amino groups in [4,5-3H]-lysine-labelled elastin.	Flavonoids	45-54	elastin	Mus musculus	175-182
6182778-1	1982	Quercetin and 12 other natural flavonoid aglycones inhibit washed human platelet aggregation and secretion of serotonin induced by ADP, collagen or thrombin.	Flavonoids	31-40	coagulation factor II, thrombin	Homo sapiens	148-156
6182778-4	1982	The inhibitory effect of flavonoids on human platelet function was diminished by saturation of the C-2, C-3 double bond, lack of the C-4 carbonyl, glycosylation at C-3 and a high number of hydroxyl substituents.	Flavonoids	25-35	complement C2	Homo sapiens	99-102
6182778-4	1982	The inhibitory effect of flavonoids on human platelet function was diminished by saturation of the C-2, C-3 double bond, lack of the C-4 carbonyl, glycosylation at C-3 and a high number of hydroxyl substituents.	Flavonoids	25-35	complement C3	Homo sapiens	104-107
6182778-4	1982	The inhibitory effect of flavonoids on human platelet function was diminished by saturation of the C-2, C-3 double bond, lack of the C-4 carbonyl, glycosylation at C-3 and a high number of hydroxyl substituents.	Flavonoids	25-35	complement C4A (Rodgers blood group)	Homo sapiens	133-136
6182778-4	1982	The inhibitory effect of flavonoids on human platelet function was diminished by saturation of the C-2, C-3 double bond, lack of the C-4 carbonyl, glycosylation at C-3 and a high number of hydroxyl substituents.	Flavonoids	25-35	complement C3	Homo sapiens	164-167
7347133-1	1981	The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition.	Flavonoids	76-89	catechol-O-methyltransferase	Homo sapiens	104-132
7347133-1	1981	The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition.	Flavonoids	76-89	catechol-O-methyltransferase	Homo sapiens	134-138
6775130-1	1980	Flavonoids are known as potent inhibitors of aldose reductase, an enzyme that may initiate cataract formation in diabetes.	Flavonoids	0-10	aldo-keto reductase family 1 member B1	Rattus norvegicus	45-61
473686-1	1979	Total flavonoids from clover red and nut, containing isoflavones, decreased the content of cholesterol and triglycerides in intact rats, inhibited the development of hyperlipidemia, caused by Triton WR-1339, prevented accumulation of triglycerides in rat liver and blood caused by ethanol administration.	Flavonoids	6-16	NUT midline carcinoma, family member 1	Rattus norvegicus	37-40
5798512-2	1969	Decomposition of flavonoids and other phenolics in soil and their effects on Fusarium root rot of bean.	Flavonoids	17-27	brain expressed associated with NEDD4 1	Homo sapiens	98-102
1145193-0	1975	Flavonoids as inhibitors of lens aldose reductase.	Flavonoids	0-10	aldo-keto reductase family 1 member B1	Rattus norvegicus	33-49
1145193-1	1975	Flavonoids are effective inhibitors of lens aldose reductase.	Flavonoids	0-10	aldo-keto reductase family 1 member B1	Rattus norvegicus	44-60
5028212-1	1972	Relationship between the structure of flavonoids and their ability to inhibit catechol-O-methyltransferase].	Flavonoids	38-48	catechol-O-methyltransferase	Homo sapiens	78-106
4470612-0	1974	[Catalytic action of flavonoids and copper in the formation of cross links of the collagen and elastin].	Flavonoids	21-31	elastin	Homo sapiens	95-102
4783557-0	1973	[On the flavonoid content of Genista rumelica Vel].	Flavonoids	8-17	small integral membrane protein 1 (Vel blood group)	Homo sapiens	46-49
4738514-2	1973	On the flavonoid and xanthone constituents of the plants of Swertia spp].	Flavonoids	7-16	histocompatibility minor 13	Homo sapiens	68-71
33476922-0	2021	Comparative study of inhibition mechanisms of structurally different flavonoid compounds on alpha-glucosidase and synergistic effect with acarbose.	Flavonoids	69-78	sucrase-isomaltase	Homo sapiens	92-109
33476922-1	2021	Flavonoid compounds have anti-diabetic activity, which can control blood glucose levels by inhibiting alpha-glucosidase activity.	Flavonoids	0-9	sucrase-isomaltase	Homo sapiens	102-119
33476922-2	2021	In this paper, the inhibition mechanisms between four flavonoid compounds and alpha-glucosidase were studied by multispectroscopic methods and molecular docking.	Flavonoids	54-63	sucrase-isomaltase	Homo sapiens	78-95
33476922-4	2021	Also, the synergistic effects of flavonoid compounds combined with acarbose on inhibiting alpha-glucosidase activity were observed.	Flavonoids	33-42	sucrase-isomaltase	Homo sapiens	90-107
33476922-5	2021	The fluorescence results showed that flavonoid compounds combined with alpha-glucosidase to form a stable complex.	Flavonoids	37-46	sucrase-isomaltase	Homo sapiens	71-88
33476922-7	2021	The present study demonstrated that the molecular structure of flavonoid compounds played an important role in the inhibition process, namely, scutellarein with more hydroxyl groups on the A-ring might serve as the most effective alpha-glucosidase inhibitor.	Flavonoids	63-72	sucrase-isomaltase	Homo sapiens	230-247
33895119-0	2021	Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinonoma cells under normoxia and hypoxia.	Flavonoids	72-82	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	45-52
33872570-5	2021	Because mechanisms that regulate ACE2 expression in the intestine are poorly understood and there is a need of anti-SARS-CoV-2 therapies, we have settled to investigate whether natural flavonoids might regulate the expression of Ace2 in intestinal models of inflammation.	Flavonoids	185-195	angiotensin converting enzyme 2	Homo sapiens	229-233
33677206-0	2021	Structural and molecular aspects of flavonoids as ligands for serum transferrin.	Flavonoids	36-46	transferrin	Homo sapiens	68-79
33677206-2	2021	Binding of flavonoids to HST produces changes in the protein structure with direct implication on iron delivery into cells.	Flavonoids	11-21	fibroblast growth factor 4	Homo sapiens	25-28
33677206-3	2021	We investigate the binding mechanism and affinity towards HST of three flavonoids: rutin, luteolin, and apigenin by different techniques: UV-Vis, fluorescence, fluorescence resonance energy transfer (FRET) combined with molecular docking.	Flavonoids	71-81	fibroblast growth factor 4	Homo sapiens	58-61
33677206-4	2021	UV-Vis results indicate an interaction between flavonoids and HST.	Flavonoids	47-57	fibroblast growth factor 4	Homo sapiens	62-65
33677206-5	2021	It was observed that HST fluorescence was quenched by these three flavonoids via a static process.	Flavonoids	66-76	fibroblast growth factor 4	Homo sapiens	21-24
33677206-8	2021	The binding of all three flavonoids increases HST stability.	Flavonoids	25-35	fibroblast growth factor 4	Homo sapiens	46-49
33677206-9	2021	These results present the potential use of HST in target-oriented delivery of flavonoids and possibly other drugs into cells.	Flavonoids	78-88	fibroblast growth factor 4	Homo sapiens	43-46
33872570-11	2021	In summary, we have provided evidence that a natural flavonoid might hold potential in reducing intestinal inflammation and ACE2 Induction in the inflamed colon in a AhR-dependent manner.	Flavonoids	53-62	angiotensin converting enzyme 2	Homo sapiens	124-128
33872570-11	2021	In summary, we have provided evidence that a natural flavonoid might hold potential in reducing intestinal inflammation and ACE2 Induction in the inflamed colon in a AhR-dependent manner.	Flavonoids	53-62	aryl hydrocarbon receptor	Homo sapiens	166-169
33411210-0	2021	The flavonoid luteolin suppresses infantile hemangioma by targeting FZD6 in the Wnt pathway.	Flavonoids	4-13	frizzled class receptor 6	Mus musculus	68-72
33070227-3	2021	Here, we report that the dietary bioflavonoid quercetin has therapeutic potential for PDA by targeting sonic hedgehog (SHH) signaling.	Flavonoids	33-45	sonic hedgehog	Mus musculus	103-117
33070227-3	2021	Here, we report that the dietary bioflavonoid quercetin has therapeutic potential for PDA by targeting sonic hedgehog (SHH) signaling.	Flavonoids	33-45	sonic hedgehog	Mus musculus	119-122
33687663-2	2021	It has been postulated that foods and supplements containing flavonoid polyphenols may enhance recovery from exercise-induced muscle damage (EIMD) through upregulation of cell signalling stress response pathways, particularly the nuclear factor erythroid 2-related factor 2 (NRF2) pathway.	Flavonoids	61-70	NFE2 like bZIP transcription factor 2	Homo sapiens	230-273
33877504-6	2021	Our findings showed that flavonoid aglycones and glycycoumarin activated TRPA1.	Flavonoids	25-34	transient receptor potential cation channel subfamily A member 1	Homo sapiens	73-78
33877504-10	2021	Hence, flavonoid aglycones metabolized by lactase-phlorizin hydrolase and beta-glucosidase in the small intestine or gut microbiota of the large intestine could generate TRPA1 agonists and TRPM8 antagonists.	Flavonoids	7-16	lactase	Homo sapiens	42-69
33877504-10	2021	Hence, flavonoid aglycones metabolized by lactase-phlorizin hydrolase and beta-glucosidase in the small intestine or gut microbiota of the large intestine could generate TRPA1 agonists and TRPM8 antagonists.	Flavonoids	7-16	transient receptor potential cation channel subfamily A member 1	Homo sapiens	170-175
33877504-10	2021	Hence, flavonoid aglycones metabolized by lactase-phlorizin hydrolase and beta-glucosidase in the small intestine or gut microbiota of the large intestine could generate TRPA1 agonists and TRPM8 antagonists.	Flavonoids	7-16	transient receptor potential cation channel subfamily M member 8	Homo sapiens	189-194
33831503-0	2021	The flavonoid quercetin reduces cell migration and increases NIS and E-cadherin mRNA in the human thyroid cancer cell line BCPAP.	Flavonoids	4-13	solute carrier family 5 member 5	Homo sapiens	61-64
33831503-0	2021	The flavonoid quercetin reduces cell migration and increases NIS and E-cadherin mRNA in the human thyroid cancer cell line BCPAP.	Flavonoids	4-13	cadherin 1	Homo sapiens	69-79
33831503-8	2021	The flavonoid also reduced matrix metalloproteinase 9 and increased E-cadherin mRNA levels, inhibiting BCPAP adhesion and migration.	Flavonoids	4-13	matrix metallopeptidase 9	Homo sapiens	27-53
33831503-8	2021	The flavonoid also reduced matrix metalloproteinase 9 and increased E-cadherin mRNA levels, inhibiting BCPAP adhesion and migration.	Flavonoids	4-13	cadherin 1	Homo sapiens	68-78
33687663-2	2021	It has been postulated that foods and supplements containing flavonoid polyphenols may enhance recovery from exercise-induced muscle damage (EIMD) through upregulation of cell signalling stress response pathways, particularly the nuclear factor erythroid 2-related factor 2 (NRF2) pathway.	Flavonoids	61-70	NFE2 like bZIP transcription factor 2	Homo sapiens	275-279
34025416-11	2021	The results of the molecular docking study further showed that the flavonoids had a strong binding affinity for ESR1 and IGF1 after docking into the crystal structure.	Flavonoids	67-77	estrogen receptor 1	Homo sapiens	112-116
34056140-7	2021	Three flavonoids parvisoflavone B (3), alpinumisoflavone (5) and norisojamicin (2) were effective in blocking the viral entry by binding strongly at the spike RBD-ACE2 interface with the inhibition constant of 0.56, 0.78 and 0.93 muM, respectively.	Flavonoids	6-16	angiotensin converting enzyme 2	Homo sapiens	163-167
34031457-1	2021	The regenerative effect of Epimedium and its major bioactive flavonoid icariin (ICA) have been documented in traditional medicine, but their effect on sarcopenia has not been evaluated.	Flavonoids	61-70	inhibitor of carbonic anhydrase	Mus musculus	80-83
33993191-13	2021	Exposure of T2D and IGT-derived MSCs to the anti-inflammatory flavonoid quercetin reduced TNFalpha levels and was paralleled by a significant decrease of the secretion of inflammatory cytokines.	Flavonoids	62-71	tumor necrosis factor	Homo sapiens	90-98
33988807-0	2021	Flavonoids modulate AMPK/PGC-1alpha and interconnected pathways toward potential neuroprotective activities.	Flavonoids	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-24
33988807-0	2021	Flavonoids modulate AMPK/PGC-1alpha and interconnected pathways toward potential neuroprotective activities.	Flavonoids	0-10	PPARG coactivator 1 alpha	Homo sapiens	25-35
33988807-8	2021	In this line, critical role of flavonoids in the upregulation of AMPK/PGC-1alpha pathway seems to pave the road in the treatment of Alzheimer"s disease (AD), Parkinson"s disease (PD), aging, central nervous system (brain/spinal cord) damages, stroke, and other NDDs.	Flavonoids	31-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	65-69
33988807-8	2021	In this line, critical role of flavonoids in the upregulation of AMPK/PGC-1alpha pathway seems to pave the road in the treatment of Alzheimer"s disease (AD), Parkinson"s disease (PD), aging, central nervous system (brain/spinal cord) damages, stroke, and other NDDs.	Flavonoids	31-41	PPARG coactivator 1 alpha	Homo sapiens	70-80
33988807-9	2021	In the present study, the regulatory role of flavonoids in managing various NDDs has been shown to pass through AMPK/PGC-1alpha signaling pathway.	Flavonoids	45-55	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	112-116
33988807-9	2021	In the present study, the regulatory role of flavonoids in managing various NDDs has been shown to pass through AMPK/PGC-1alpha signaling pathway.	Flavonoids	45-55	PPARG coactivator 1 alpha	Homo sapiens	117-127
33961144-7	2021	Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-alpha, NF-kappaB, IL-1beta, and IL-6.	Flavonoids	0-10	tumor necrosis factor	Homo sapiens	167-176
33961144-7	2021	Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-alpha, NF-kappaB, IL-1beta, and IL-6.	Flavonoids	0-10	nuclear factor kappa B subunit 1	Homo sapiens	178-187
33961144-7	2021	Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-alpha, NF-kappaB, IL-1beta, and IL-6.	Flavonoids	0-10	interleukin 1 alpha	Homo sapiens	189-197
33961144-7	2021	Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-alpha, NF-kappaB, IL-1beta, and IL-6.	Flavonoids	0-10	interleukin 6	Homo sapiens	203-207
33539218-2	2021	Therefore, identification of CYP2E1 inhibitor from bioflavonoids class having useful pharmacological properties has dual benefit regarding avoidance of severe food-drug/nutraceutical-drug interaction and scope to develop a phytotherapeutics through an intended pharmacokinetic interaction.	Flavonoids	51-64	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	29-35
33539218-3	2021	In the present study, we aimed to identify CYP2E1 inhibitor from experimental bioflavonoids which are unexplored for CYP2E1 inhibition till date using in-silico, in-vitro and in-vivo approaches.	Flavonoids	78-91	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	43-49
33539218-3	2021	In the present study, we aimed to identify CYP2E1 inhibitor from experimental bioflavonoids which are unexplored for CYP2E1 inhibition till date using in-silico, in-vitro and in-vivo approaches.	Flavonoids	78-91	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	117-123
34009430-9	2021	CONCLUSIONS: Higher intakes of dietary flavonoids, specifically flavonols and flavan-3-ols, could be associated with better long-term treatment outcomes in nAMD patients receiving anti-VEGF therapy.	Flavonoids	39-49	vascular endothelial growth factor A	Homo sapiens	185-189
33727059-6	2021	The present review, by examining numerous studies, summarizes the state-of-the-art in this field, describing the most significant examples of direct and indirect inhibition of the hERG channel current operated by flavonoids.	Flavonoids	213-223	ETS transcription factor ERG	Homo sapiens	180-184
33737009-1	2021	Earlier we have shown that certain flavonoids (e.g., quercetin) are high-affinity reducing cosubstrates for cyclooxygenase (COX) 1 and 2.	Flavonoids	35-45	prostaglandin-endoperoxide synthase 1	Homo sapiens	108-136
34025416-11	2021	The results of the molecular docking study further showed that the flavonoids had a strong binding affinity for ESR1 and IGF1 after docking into the crystal structure.	Flavonoids	67-77	insulin like growth factor 1	Homo sapiens	121-125
33756125-7	2021	Herein, we employed the synergetic combination of virtual and experimental screening to identify a flavonoid compound which not only effectively inhibits AR transcriptional activity, but also induces the degradation of the protein.	Flavonoids	99-108	androgen receptor	Homo sapiens	154-156
33652057-11	2021	Specifically, numerous NPs including flavonoids, gingerols, tannins, anthocyanins, triterpenes and alkaloids have been shown anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-choLinesterase properties.	Flavonoids	37-47	butyrylcholinesterase	Homo sapiens	186-200
33966617-0	2022	The Molecular Mechanism of Scutellaria baicalensis Georgi Stems and Leaves Flavonoids in Promoting Neurogenesis and Improving Memory Impairment by the PI3K-AKT-CREB Signaling Pathway in Rats.	Flavonoids	75-85	AKT serine/threonine kinase 1	Rattus norvegicus	156-159
33966617-0	2022	The Molecular Mechanism of Scutellaria baicalensis Georgi Stems and Leaves Flavonoids in Promoting Neurogenesis and Improving Memory Impairment by the PI3K-AKT-CREB Signaling Pathway in Rats.	Flavonoids	75-85	cAMP responsive element binding protein 1	Rattus norvegicus	160-164
33966617-1	2022	AIM: The aim of this study was to investigate the effect, and molecular mechanism of Scutellaria Baicalensis Georgi stems and leaves flavonoids (SSF) in promoting neurogenesis and improving memory impairment induced by the PI3K-AKT-CREB signaling pathway.	Flavonoids	133-143	AKT serine/threonine kinase 1	Rattus norvegicus	228-231
33966617-1	2022	AIM: The aim of this study was to investigate the effect, and molecular mechanism of Scutellaria Baicalensis Georgi stems and leaves flavonoids (SSF) in promoting neurogenesis and improving memory impairment induced by the PI3K-AKT-CREB signaling pathway.	Flavonoids	133-143	cAMP responsive element binding protein 1	Rattus norvegicus	232-236
33950049-12	2021	Significant protection and decreased MPO and EPO activity were detected in the periodontal tissue of citrus flavonoid-treated animals.	Flavonoids	108-117	myeloperoxidase	Mus musculus	37-40
33950049-12	2021	Significant protection and decreased MPO and EPO activity were detected in the periodontal tissue of citrus flavonoid-treated animals.	Flavonoids	108-117	eosinophil peroxidase	Mus musculus	45-48
33939580-0	2021	A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities.	Flavonoids	6-15	sucrase-isomaltase	Homo sapiens	65-82
34007298-6	2021	Results: Serum tests showed that total flavonoids from D. moldavica L. significantly increased the Apo-A1 and Apo-E levels in rats with CMS (P < 0.05).	Flavonoids	39-49	apolipoprotein A1	Rattus norvegicus	99-105
34007298-6	2021	Results: Serum tests showed that total flavonoids from D. moldavica L. significantly increased the Apo-A1 and Apo-E levels in rats with CMS (P < 0.05).	Flavonoids	39-49	apolipoprotein E	Rattus norvegicus	110-115
33939580-0	2021	A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities.	Flavonoids	6-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
33556870-2	2021	It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1.	Flavonoids	143-153	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	20-39
33556870-2	2021	It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1.	Flavonoids	143-153	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	41-47
33556870-2	2021	It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1.	Flavonoids	143-153	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	258-264
33556870-4	2021	This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity.	Flavonoids	205-215	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	224-230
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	AKT serine/threonine kinase 1	Homo sapiens	117-120
33516906-0	2021	The flavonoids of okra insulates against oxidative stress, neuroinflammation and restores BDNF levels in Abeta1-42 induced mouse model of Alzheimer"s disease.	Flavonoids	4-14	brain derived neurotrophic factor	Mus musculus	90-94
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	mechanistic target of rapamycin kinase	Homo sapiens	122-126
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	epidermal growth factor receptor	Homo sapiens	128-132
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	mitogen-activated protein kinase kinase 4	Homo sapiens	140-144
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	146-149
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	151-154
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	156-160
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	Janus kinase 2	Homo sapiens	162-165
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	signal transducer and activator of transcription 1	Homo sapiens	167-172
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	signal transducer and activator of transcription 3	Homo sapiens	174-179
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	signal transducer and activator of transcription 4	Homo sapiens	181-186
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	signal transducer and activator of transcription 5A	Homo sapiens	188-193
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	vascular endothelial growth factor A	Homo sapiens	199-203
33647348-5	2021	Among flavonoids acacetin showed highest binding-energy against JAK-2 following FYN > VEGF > PI3K > MKK4 > MAPK > BRAF > STAT5 > STAT1 > STAT4 whereas pinostrobin depicts higher binding-energy with JAK-2 followed by BRAF > MKK4 > VEGF > PI3K > MAPK > STAT1 > STAT4 > STAT5.	Flavonoids	6-16	Janus kinase 2	Homo sapiens	64-69
33423292-0	2021	Positional preferences in flavonoids for inhibition of Ribonuclease A: Where "-OH" where?	Flavonoids	26-36	ribonuclease A family member 1, pancreatic	Homo sapiens	55-69
33760114-0	2021	Total flavonoids of Rhizoma drynariae ameliorate steroid-induced avascular necrosis of the femoral head via the PI3K/AKT pathway.	Flavonoids	6-16	AKT serine/threonine kinase 1	Rattus norvegicus	117-120
32321364-3	2021	In this study, the newly isolated flavonoid analogs were docked against the NS1 protein.	Flavonoids	34-43	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	76-79
32321364-8	2021	These flavonoids analogs can inhibit the hexamerization of the NS1 which is necessary for the Zika virus replication.	Flavonoids	6-16	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	63-66
33735724-0	2021	A novel flavonoid from Fissistigma cupreonitens, 5-hydroxy-7,8-dimethoxyflavanone, competitively inhibited the efflux function of human P-glycoprotein and reversed cancer multi-drug resistance.	Flavonoids	8-17	ATP binding cassette subfamily B member 1	Homo sapiens	136-150
33735724-3	2021	PURPOSE AND STUDY DESIGN: The aim of the present study was to research the P-gp modulating effects and MDR reversing ability of a novel flavonoid from Fissistigma cupreonitens, the underlying inhibitory mechanisms were further elucidated as well.	Flavonoids	136-145	ATP binding cassette subfamily B member 1	Homo sapiens	75-79
33735724-12	2021	CONCLUSION: The present study demonstrated that 5-hydroxy-7,8-dimethoxyflavanone was a novel effective flavonoid in the P-gp efflux inhibition and in vitro cancer MDR reversion.	Flavonoids	103-112	ATP binding cassette subfamily B member 1	Homo sapiens	120-124
33423292-2	2021	The structure-activity relationship of certain flavonoids and resveratrol with Ribonuclease A (RNase A) have been investigated.	Flavonoids	47-57	ribonuclease A family member 1, pancreatic	Homo sapiens	79-93
33423292-2	2021	The structure-activity relationship of certain flavonoids and resveratrol with Ribonuclease A (RNase A) have been investigated.	Flavonoids	47-57	ribonuclease A family member 1, pancreatic	Homo sapiens	95-102
33423292-3	2021	The selected flavonoids have a similar skeleton and the positional preferences of the phenolic moieties towards inhibition of the catalytic activity of RNase A have been studied.	Flavonoids	13-23	ribonuclease A family member 1, pancreatic	Homo sapiens	152-159
33423292-4	2021	The results obtained for RNase A inhibition by flavonoids suggest that the planarity of the molecules is necessary for effective inhibitory potency.	Flavonoids	47-57	ribonuclease A family member 1, pancreatic	Homo sapiens	25-32
33423292-6	2021	Minor secondary structural changes of RNase A were observed after interaction with the flavonoids.	Flavonoids	87-97	ribonuclease A family member 1, pancreatic	Homo sapiens	38-45
33423292-8	2021	The dipole moment of the flavonoids that depends on the orientation of the hydroxyl groups in the molecule bears direct correlation with the inhibitory potency against RNase A.	Flavonoids	25-35	ribonuclease A family member 1, pancreatic	Homo sapiens	168-175
33875769-0	2021	Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.	Flavonoids	0-10	two pore segment channel 2	Homo sapiens	144-148
34012333-11	2021	In molecular docking, the annotated flavonoids displayed appreciable binding affinities to the active sites of VEGFR1 and VEGFR2.	Flavonoids	36-46	FMS-like tyrosine kinase 1	Mus musculus	111-117
34012333-11	2021	In molecular docking, the annotated flavonoids displayed appreciable binding affinities to the active sites of VEGFR1 and VEGFR2.	Flavonoids	36-46	kinase insert domain protein receptor	Mus musculus	122-128
33932529-0	2021	Discovery and characterization of flavonoids in vine tea as catechol-O-methyltransferase inhibitors.	Flavonoids	34-44	catechol-O-methyltransferase	Homo sapiens	60-88
33932529-4	2021	Five flavonoids in vine tea displayed moderate to strong inhibition on hCOMT with IC50 values ranging from 0.96 muM to 42.47 muM, in which myricetin was the critically potent constituent against hCOMT.	Flavonoids	5-15	catechol-O-methyltransferase	Homo sapiens	71-76
33932529-4	2021	Five flavonoids in vine tea displayed moderate to strong inhibition on hCOMT with IC50 values ranging from 0.96 muM to 42.47 muM, in which myricetin was the critically potent constituent against hCOMT.	Flavonoids	5-15	catechol-O-methyltransferase	Homo sapiens	195-200
33922069-11	2021	Collectively, our conclusions emphasized the significant function of SlGRAS10 as a stress tolerate transcription factor in a certain variety of abiotic stress tolerance by enhancing osmotic potential, flavonoid biosynthesis, and ROS scavenging system in the tomato plant.	Flavonoids	201-210	GRAS10 protein	Solanum lycopersicum	69-77
33995548-0	2021	Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF-kappaB and PI3K/AKT Pathways.	Flavonoids	6-16	matrix metallopeptidase 1	Homo sapiens	50-53
33995548-0	2021	Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF-kappaB and PI3K/AKT Pathways.	Flavonoids	6-16	TIMP metallopeptidase inhibitor 1	Homo sapiens	54-58
33995548-0	2021	Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF-kappaB and PI3K/AKT Pathways.	Flavonoids	6-16	nuclear factor kappa B subunit 1	Homo sapiens	131-140
33995548-0	2021	Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF-kappaB and PI3K/AKT Pathways.	Flavonoids	6-16	AKT serine/threonine kinase 1	Homo sapiens	150-153
33922069-5	2021	Down-regulation of SlGRAS10 by RNA interference (RNAi) produced dwarf plants with smaller leaves, internode lengths, and enhanced flavonoid accumulation.	Flavonoids	130-139	GRAS10 protein	Solanum lycopersicum	19-27
33923487-0	2021	Plant Occurring Flavonoids as Modulators of the Aryl Hydrocarbon Receptor.	Flavonoids	16-26	aryl hydrocarbon receptor	Homo sapiens	48-73
33923487-3	2021	Multiple AhR ligands are recognized, with plant occurring flavonoids being the largest group of natural ligands of AhR in the human diet.	Flavonoids	58-68	aryl hydrocarbon receptor	Homo sapiens	115-118
33923487-4	2021	The biological implications of the modulatory effects of flavonoids on AhR could be highlighted from a toxicological and environmental concern and for the possible pharmacological applicability.	Flavonoids	57-67	aryl hydrocarbon receptor	Homo sapiens	71-74
33923487-5	2021	Overall, the possible AhR-mediated harmful and/or beneficial effects of flavonoids need to be further investigated, since in many cases they are contradictory.	Flavonoids	72-82	aryl hydrocarbon receptor	Homo sapiens	22-25
33923487-6	2021	Similar to other AhR modulators, flavonoids commonly exhibit tissue, organ, and species-specific activities on AhR.	Flavonoids	33-43	aryl hydrocarbon receptor	Homo sapiens	17-20
33923487-6	2021	Similar to other AhR modulators, flavonoids commonly exhibit tissue, organ, and species-specific activities on AhR.	Flavonoids	33-43	aryl hydrocarbon receptor	Homo sapiens	111-114
33923487-8	2021	Flavones, flavonols, flavanones, and isoflavones are the main subclasses of flavonoids reported as AhR modulators.	Flavonoids	76-86	aryl hydrocarbon receptor	Homo sapiens	99-102
33923487-9	2021	Some of the structural features of these groups of flavonoids that could be influencing their AhR effects are herein summarized.	Flavonoids	51-61	aryl hydrocarbon receptor	Homo sapiens	94-97
33863923-10	2021	Altogether, the current study confirmed that the dietary flavonoid, fisetin, inhibited LPS-induced inflammation and endotoxic shock through crosstalk between GSK-3beta/beta-catenin and the NF-kappaB signaling pathways.	Flavonoids	57-66	glycogen synthase kinase 3 alpha b	Danio rerio	158-167
33749262-0	2021	Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-kappaB/MLCK and Nrf2 Signaling Pathways.	Flavonoids	67-76	nuclear factor kappa B subunit 1	Homo sapiens	95-104
33863923-10	2021	Altogether, the current study confirmed that the dietary flavonoid, fisetin, inhibited LPS-induced inflammation and endotoxic shock through crosstalk between GSK-3beta/beta-catenin and the NF-kappaB signaling pathways.	Flavonoids	57-66	catenin (cadherin-associated protein), beta 1	Danio rerio	168-180
33609662-0	2021	Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways.	Flavonoids	11-21	AKT serine/threonine kinase 1	Homo sapiens	81-84
33749262-0	2021	Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-kappaB/MLCK and Nrf2 Signaling Pathways.	Flavonoids	67-76	myosin light chain kinase	Homo sapiens	105-109
33749262-0	2021	Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-kappaB/MLCK and Nrf2 Signaling Pathways.	Flavonoids	67-76	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
33924405-0	2021	Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3"-Disulfate.	Flavonoids	81-90	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	6-37
33847382-4	2021	In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis.	Flavonoids	53-62	angiotensin converting enzyme 2	Homo sapiens	131-135
33927630-12	2021	The possible interventions by curcumin, resveratrol, cannabidiol, ginsenosides, flavonoids and sulforaphane on microglia specific protein Iba1 suggest possibility of natural products mediated regulation of microglia phenotypes and its functions to control redox imbalance and neuroinflammation in management of Alzheimer"s, Parkinson"s and Multiple Sclerosis for microglia-mediated therapeutics.	Flavonoids	80-90	allograft inflammatory factor 1	Homo sapiens	138-142
33924405-0	2021	Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3"-Disulfate.	Flavonoids	81-90	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	39-46
33924405-5	2021	Here, we show that the natural flavonoid, luteolin 7,3"-disulfate, inhibits CYP51A1 activity.	Flavonoids	31-40	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	76-83
33924405-11	2021	Overall, flavonoids have the potential to inhibit the activity of human CYP51A1 and should be further explored for their cholesterol-lowering and anti-cancer activity.	Flavonoids	9-19	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	72-79
33917039-0	2021	Identification of Flavonoids as Putative ROS-1 Kinase Inhibitors Using Pharmacophore Modeling for NSCLC Therapeutics.	Flavonoids	18-28	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	41-46
33918053-10	2021	We propose that ABCC6 expression may be controlled by the AKT pathway as part of an adaptative response to oxidative stress, which can be mitigated by the use of Quercetin-like flavonoids.	Flavonoids	177-187	ATP binding cassette subfamily C member 6	Homo sapiens	16-21
33918053-10	2021	We propose that ABCC6 expression may be controlled by the AKT pathway as part of an adaptative response to oxidative stress, which can be mitigated by the use of Quercetin-like flavonoids.	Flavonoids	177-187	AKT serine/threonine kinase 1	Homo sapiens	58-61
33917039-8	2021	The binding free energy calculations computed via molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) demonstrated one flavonoid (Hit) with better energy than lorlatinib in binding with WT and MT ROS-1.	Flavonoids	128-137	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	205-210
33238041-3	2021	Several studies have shown that continued consumption of flavonoids can increase the risk of food/drug-drug interaction by affecting the activities of human cytochrome CYP3A4 and 2D6.	Flavonoids	57-67	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	168-182
33359860-10	2021	CONCLUSION: These results exhibited anti-breast-cancer potential of MeZb through Nrf2-Keap1 pathway which may be due to the flavonoids, alkaloids and glycosides present in it.	Flavonoids	124-134	Kelch-like ECH-associated protein 1	Rattus norvegicus	86-91
33440222-7	2021	Interestingly, our data additionally showed a definitive correlation of leaf reddening symptoms with increased expression of chalcone synthase, thus suggesting upregulation of the flavonoid biosynthesis pathway as the molecular basis for symptom induction in maize.	Flavonoids	180-189	chalcone synthase	Zea mays	125-142
33823775-8	2021	Apart from them, natural bioactive ingredients from plants, such as flavonoids, polyphenols, alkaloids, terpenoids, polysaccharides, and quinones are efficient in helping weight loss and improving insulin sensitivity and glycemic control.	Flavonoids	68-78	insulin	Homo sapiens	197-204
33918387-0	2021	Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line.	Flavonoids	20-30	tumor protein p53	Homo sapiens	100-103
33577894-5	2021	Aglycone flavonoids and atuveciclib, but not L7G, also inhibit CDK9 and the HIV Tat protein.	Flavonoids	9-19	cyclin dependent kinase 9	Homo sapiens	63-67
33577894-5	2021	Aglycone flavonoids and atuveciclib, but not L7G, also inhibit CDK9 and the HIV Tat protein.	Flavonoids	9-19	tyrosine aminotransferase	Homo sapiens	80-83
33636437-0	2021	Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors.	Flavonoids	0-10	ns2b-ns3 protease	None	47-64
33577894-6	2021	Aglycone flavonoids do not reinforce HIV latency following their in vitro withdrawal, which corresponds with their ability to also inhibit class I/II histone deacetylases (HDAC), a well-established mechanism of latency reversal.	Flavonoids	9-19	histone deacetylase 9	Homo sapiens	150-170
33577894-0	2021	Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency.	Flavonoids	0-9	cyclin dependent kinase 9	Homo sapiens	30-55
33577894-6	2021	Aglycone flavonoids do not reinforce HIV latency following their in vitro withdrawal, which corresponds with their ability to also inhibit class I/II histone deacetylases (HDAC), a well-established mechanism of latency reversal.	Flavonoids	9-19	histone deacetylase 9	Homo sapiens	172-176
33410021-9	2021	These above results are well corroborated with the histopathological findings performed in the brain tissue, along with the increased upregulation seen in the Nrf2 signalling, with all the flavonoid co-treatment carried in the kidney tissue.	Flavonoids	189-198	nuclear factor, erythroid derived 2, like 2	Mus musculus	159-163
32715386-0	2021	A natural flavonoid, apigenin isolated from Clerodendrum viscosum leaves, induces G2/M phase cell cycle arrest and apoptosis in MCF-7 cells through the regulation of p53 and caspase-cascade pathway.	Flavonoids	10-19	tumor protein p53	Homo sapiens	166-169
33410021-11	2021	Our findings revealed the beneficial effects of the flavonoids against the arsenic-induced toxicity, due to their ability to enhance the intracellular antioxidant response system by modulating the Nrf2 signaling pathway.	Flavonoids	52-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	197-201
32981207-4	2021	Myricetin is a natural flavonoid that exhibits a specific anti-STAT1 activity correlated with its direct interaction with STAT1 protein itself.	Flavonoids	23-32	signal transducer and activator of transcription 1	Homo sapiens	63-68
32981207-4	2021	Myricetin is a natural flavonoid that exhibits a specific anti-STAT1 activity correlated with its direct interaction with STAT1 protein itself.	Flavonoids	23-32	signal transducer and activator of transcription 1	Homo sapiens	122-127
33687091-0	2021	Using of group-based selected flavonoids as alternative inhibitors for potato polyphenol oxidase.	Flavonoids	30-40	catechol oxidase B, chloroplastic	Solanum tuberosum	78-96
33122822-0	2021	The bioflavonoid troxerutin prevents gestational hypertension in mice by inhibiting STAT3 signaling.	Flavonoids	4-16	signal transducer and activator of transcription 3	Mus musculus	84-89
33687091-5	2021	Marfona) by limiting the polyphenol oxidase (PPO) activity with selected flavonoids.	Flavonoids	73-83	catechol oxidase B, chloroplastic	Solanum tuberosum	45-48
33687091-12	2021	In this current paper, group-based selected flavonoids were proposed as alternative inhibitors of potato PPO enzyme.	Flavonoids	44-54	catechol oxidase B, chloroplastic	Solanum tuberosum	105-108
33687091-13	2021	These flavonoids allowing to limit the PPO activity are commercially available, and they can be potential candidates to be used as antibrowning agents during potato processing.	Flavonoids	6-16	catechol oxidase B, chloroplastic	Solanum tuberosum	39-42
33509902-3	2021	However, the function and mechanism of apigenin (AP, a kind of flavonoids) on IR are still unclear.	Flavonoids	63-73	LIM homeobox protein 2	Mus musculus	49-51
31385536-0	2021	Two novel flavonoids from the leaves of Rhododendron dauricum L. with their inhibition of TNF-alpha production in LPS-induced RAW 264.7 cells.	Flavonoids	10-20	tumor necrosis factor	Mus musculus	90-99
31385536-2	2021	The isolated flavonoids were evaluated for their inhibitory effects on the production of tumour necrosis factor (TNF)-alpha in LPS-stimulated RAW 264.7 cells.	Flavonoids	13-23	tumor necrosis factor	Mus musculus	89-123
33089636-0	2021	Three AP2/ERF family members modulate flavonoid synthesis by regulating type IV chalcone isomerase in citrus.	Flavonoids	38-47	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	6-9
33749550-3	2022	In the past decade, most reported PK inhibitors including indole, flavonoid, phenazine derivative from natural product small molecules or their analogues, or virtual screening from small molecule compound library.	Flavonoids	66-75	AT695_RS09030	Staphylococcus aureus	34-36
33493355-1	2021	BACKGROUND: Our previous report has shown that the flavonoid 2"-hydroxyflavanone (2"-HF) showed inhibition of androgen receptor (AR) activity against androgen-sensitive prostate cancer (PCa) cells, LNCaP, and exhibited antitumor effects against androgen-insensitive PCa cells, PC-3, and DU145.	Flavonoids	51-60	androgen receptor	Homo sapiens	110-127
33493355-1	2021	BACKGROUND: Our previous report has shown that the flavonoid 2"-hydroxyflavanone (2"-HF) showed inhibition of androgen receptor (AR) activity against androgen-sensitive prostate cancer (PCa) cells, LNCaP, and exhibited antitumor effects against androgen-insensitive PCa cells, PC-3, and DU145.	Flavonoids	51-60	androgen receptor	Homo sapiens	129-131
33774830-2	2021	Flavonol synthetase (FLS) is one of the key enzymes to synthesize flavonoids.	Flavonoids	66-76	flavonol synthase 1	Arabidopsis thaliana	0-19
33774830-2	2021	Flavonol synthetase (FLS) is one of the key enzymes to synthesize flavonoids.	Flavonoids	66-76	flavonol synthase 1	Arabidopsis thaliana	21-24
33774830-3	2021	However, the role of the FLS gene in flavonoid accumulation and tolerance to abiotic stresses, as well as its mechanism has not yet been investigated systematically in plants.	Flavonoids	37-46	flavonol synthase 1	Arabidopsis thaliana	25-28
33570057-2	2021	Previously, we revealed that rhamnetin (a flavonoid functioning as an inhibitor of sirtuin (Sirt)1) could inhibit expression of the downstream gene of the PXR: multidrug resistance 1 (mdr-1).	Flavonoids	42-51	sirtuin 1	Homo sapiens	83-98
33652358-10	2021	It revealed that the extract of D. odorifera and nine flavonoids in the noncytotoxic range could alleviated lipopolysaccharide-stimulated inflammation in RAW 264.7 cells by decreasing the production of proinflammatory mediators such as nitric oxide and interleukin-6.	Flavonoids	54-64	interleukin 6	Mus musculus	253-266
33271248-0	2021	Antidiabetic Effect of a Flavonoid-Rich Extract from Sophora alopecuroides L. in HFD- and STZ- Induced Diabetic Mice through PKC/GLUT4 Pathway and Regulating PPARalpha and PPARgamma expression.	Flavonoids	25-34	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	129-134
33271248-0	2021	Antidiabetic Effect of a Flavonoid-Rich Extract from Sophora alopecuroides L. in HFD- and STZ- Induced Diabetic Mice through PKC/GLUT4 Pathway and Regulating PPARalpha and PPARgamma expression.	Flavonoids	25-34	peroxisome proliferator activated receptor alpha	Mus musculus	158-167
33271248-0	2021	Antidiabetic Effect of a Flavonoid-Rich Extract from Sophora alopecuroides L. in HFD- and STZ- Induced Diabetic Mice through PKC/GLUT4 Pathway and Regulating PPARalpha and PPARgamma expression.	Flavonoids	25-34	peroxisome proliferator activated receptor gamma	Mus musculus	172-181
33570057-2	2021	Previously, we revealed that rhamnetin (a flavonoid functioning as an inhibitor of sirtuin (Sirt)1) could inhibit expression of the downstream gene of the PXR: multidrug resistance 1 (mdr-1).	Flavonoids	42-51	nuclear receptor subfamily 1 group I member 2	Homo sapiens	155-158
33570057-2	2021	Previously, we revealed that rhamnetin (a flavonoid functioning as an inhibitor of sirtuin (Sirt)1) could inhibit expression of the downstream gene of the PXR: multidrug resistance 1 (mdr-1).	Flavonoids	42-51	ATP binding cassette subfamily B member 1	Homo sapiens	160-182
33719855-5	2021	Three flavonoids isorhamnetin (1), kaempferol (2) and apigenin (3) showed good binding affinity, stable protein-ligand complexes throughout the simulation time, high binding energy and similar binding poses in comparison with known SARS-CoV-2 Mpro inhibitor baicalein.	Flavonoids	6-16	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	243-247
33570057-2	2021	Previously, we revealed that rhamnetin (a flavonoid functioning as an inhibitor of sirtuin (Sirt)1) could inhibit expression of the downstream gene of the PXR: multidrug resistance 1 (mdr-1).	Flavonoids	42-51	ATP binding cassette subfamily B member 1	Homo sapiens	184-189
33731677-3	2021	Apigenin, a dietary flavonoid, sensitizes lung cancer cell lines to TRAIL.	Flavonoids	20-29	TNF superfamily member 10	Homo sapiens	68-73
33732929-10	2021	Therefore, given the innate ability of D-AP to block cell proliferation and induce early apoptosis, we conclude that deuteration enhances the systemic anti-cancer effect of this flavonoid.	Flavonoids	178-187	LIM homeobox protein 2	Mus musculus	41-43
33678040-1	2021	Apigenin, a flavonoid, is reported to act as an estrogen receptor (ER) agonist and inhibit aromatase enzyme.	Flavonoids	12-21	estrogen receptor 1	Homo sapiens	48-65
33678040-1	2021	Apigenin, a flavonoid, is reported to act as an estrogen receptor (ER) agonist and inhibit aromatase enzyme.	Flavonoids	12-21	estrogen receptor 1	Homo sapiens	67-69
33693759-14	2021	These findings support the beneficial actions of these flavonoids in sustaining intestinal and glucose homeostasis through the modulation of the GLP-1 metabolism.	Flavonoids	55-65	glucagon	Mus musculus	145-150
33357981-0	2021	Combined in silico and in vitro studies to identify novel antidiabetic flavonoids targeting glycogen phosphorylase.	Flavonoids	71-81	ring finger protein 130	Homo sapiens	92-114
33661906-5	2021	The flavonoids are noncompetitive inhibitors and the determined IC50 values are in low microM range for HST against ZIKV NS2B/NS3pro (12.6 +- 1.3 microM) and against CHIKV nsP2pro (2.5 +- 0.4 microM).	Flavonoids	4-14	KRAS proto-oncogene, GTPase	Homo sapiens	126-129
33889398-0	2021	Association between dietary flavonoid intakes and C-reactive protein levels: a cross-sectional study in Taiwan.	Flavonoids	28-37	C-reactive protein	Homo sapiens	50-68
33889398-1	2021	Although the intake of specific flavonoid-rich foods may reduce C-reactive protein (CRP) levels, the association between dietary flavonoid intakes and CRP is inconsistent.	Flavonoids	32-41	C-reactive protein	Homo sapiens	64-82
33889398-1	2021	Although the intake of specific flavonoid-rich foods may reduce C-reactive protein (CRP) levels, the association between dietary flavonoid intakes and CRP is inconsistent.	Flavonoids	32-41	C-reactive protein	Homo sapiens	84-87
33889398-2	2021	We aim to describe dietary flavonoid intakes in a Taiwanese nationally representative sample and to investigate the association between flavonoid intakes and CRP.	Flavonoids	136-145	C-reactive protein	Homo sapiens	158-161
33889398-5	2021	Adjusted estimates of the flavonoid intakes for the continuous and binary (elevated CRP: >0 3 mg/dl) variables were performed by using general linear and logistic regression.	Flavonoids	26-35	C-reactive protein	Homo sapiens	84-87
33889398-8	2021	Compared with the lowest total flavonoid intake quartile, participants in higher quartiles were associated with a lower CRP status (adjusted odds ratio (OR): 0 61, 95 % confidence interval (CI): 0 44-0 86 for the highest quartiles).	Flavonoids	31-40	C-reactive protein	Homo sapiens	120-123
33889398-11	2021	In brief, a higher total flavonoid intake and tea consumption were inversely associated with CRP levels, indicating that a high-flavonoid diet may contribute to anti-inflammatory effects.	Flavonoids	25-34	C-reactive protein	Homo sapiens	93-96
33889398-11	2021	In brief, a higher total flavonoid intake and tea consumption were inversely associated with CRP levels, indicating that a high-flavonoid diet may contribute to anti-inflammatory effects.	Flavonoids	128-137	C-reactive protein	Homo sapiens	93-96
33530021-0	2021	A role of flavonoids in cytochrome c-cardiolipin interactions.	Flavonoids	10-20	cytochrome c, somatic	Homo sapiens	24-36
33530021-2	2021	In the present work, we studied the effect of 17 dietary flavonoids on the peroxidase activity of cyt c bound to liposomes.	Flavonoids	57-67	cytochrome c, somatic	Homo sapiens	98-103
33530021-3	2021	Specifically, we explored the relationship between peroxidase activity and flavonoids" (1) potential to modulate cyt c unfolding, (2) effect on the oxidation state of heme iron, (3) membrane permeability, (4) membrane binding energy, and (5) structure.	Flavonoids	75-85	cytochrome c, somatic	Homo sapiens	113-118
33530021-5	2021	Flavonoids" peroxidase inhibition activity correlated positively with their potential to suppress Trp-59 fluorescence in cyt c as well as the number of OH groups.	Flavonoids	0-10	cytochrome c, somatic	Homo sapiens	121-126
33450055-0	2021	Molecular mechanism and pharmacokinetics of flavonoids in the treatment of resistant EGFR-mutated non-small-cell lung cancer: a narrative review.	Flavonoids	44-54	epidermal growth factor receptor	Homo sapiens	85-89
33450055-1	2021	This paper reviews the molecular mechanism and pharmacokinetics of flavonoids in the treatment of resistant EGFR-mutated non-small-cell lung cancer (NSCLC) and pointed out the possible mechanism of delicaflavone, a biflavonoid extracted from S. doederleinii Hieron.	Flavonoids	67-77	epidermal growth factor receptor	Homo sapiens	108-112
33450055-4	2021	In laboratory studies, flavonoids, as potential adjuvants for cancer chemotherapy, exhibited anti-cancer properties such as inhibition of chemoresistance by interference with ABC transporters-induced drug efflux, curbing of c-MET amplification, or reversal of T790M mutation-mediated resistance.	Flavonoids	23-33	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	175-178
33450055-4	2021	In laboratory studies, flavonoids, as potential adjuvants for cancer chemotherapy, exhibited anti-cancer properties such as inhibition of chemoresistance by interference with ABC transporters-induced drug efflux, curbing of c-MET amplification, or reversal of T790M mutation-mediated resistance.	Flavonoids	23-33	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	224-229
33748510-5	2021	Over 100 different flavonoids with antioxidant, anti-inflammatory, and antiviral properties from different literatures were taken as a ligand or inhibitor for molecular docking against target protein RBD of nCoV-SP and ACE-2 using PyRX and iGEMDOCK.	Flavonoids	19-29	angiotensin converting enzyme 2	Homo sapiens	219-224
33748510-8	2021	Molecular dynamics simulation studies up to 100 ns exhibited strong binding affinity of selected flavonoids to RBD of nCoV-SP and ACE-2, and the protein-ligand complexes were structurally stable.	Flavonoids	97-107	angiotensin converting enzyme 2	Homo sapiens	130-135
33439402-2	2021	In this present work, a set of alkaloids and flavonoids against AChE enzyme were screened by computational chemistry techniques.	Flavonoids	45-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
33246112-7	2021	The major pathways targeted by licorice flavonoids include: the MAPK pathway, PI3K/AKT pathway, NF-kappaB pathway, death receptor - dependent extrinsic signaling pathway, and mitochondrial apoptotic pathway.	Flavonoids	40-50	AKT serine/threonine kinase 1	Homo sapiens	83-86
33357981-3	2021	Natural products, and in particular flavonoids, have been reported as potent inhibitors of GP at the cellular level.	Flavonoids	36-46	ring finger protein 130	Homo sapiens	91-93
33357981-4	2021	Herein, free-energy calculations and microscale thermophoresis approaches were performed to get an in-depth assessment of the binding affinities and elucidate intermolecular interactions of several flavonoids at the inhibitor site of GP.	Flavonoids	198-208	ring finger protein 130	Homo sapiens	234-236
33357981-6	2021	We identified: i) the residues Phe285, Tyr613, Glu382 and/or Arg770 as the most relevant for the binding of the best flavonoids to the inhibitor site of GP, and ii) the 5-OH, 7-OH, 8-prenyl substitutions in ring A and the 4"-OH insertion in ring B to favor flavonoid binding at this site.	Flavonoids	117-127	ring finger protein 130	Homo sapiens	153-155
33357981-6	2021	We identified: i) the residues Phe285, Tyr613, Glu382 and/or Arg770 as the most relevant for the binding of the best flavonoids to the inhibitor site of GP, and ii) the 5-OH, 7-OH, 8-prenyl substitutions in ring A and the 4"-OH insertion in ring B to favor flavonoid binding at this site.	Flavonoids	117-126	ring finger protein 130	Homo sapiens	153-155
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Flavonoids	57-67	angiotensin converting enzyme 2	Homo sapiens	203-207
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Flavonoids	57-67	helicase for meiosis 1	Homo sapiens	241-249
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Flavonoids	57-67	angiotensin I converting enzyme	Homo sapiens	203-206
33253545-6	2021	Within both, the HTS data were seen to reflect estrogenic potencies in a manner which broadly corresponded to established structure-activity group relationships, with parabens and flavonoids displaying greater estrogen receptor affinity than benzoate esters and alternative pyranone-containing molecules, respectively.	Flavonoids	180-190	estrogen receptor 1	Homo sapiens	210-227
33486093-3	2021	Similarly, the Arabidopsis transcription factor PAP1 was found to enhance flavonoid accumulation by upregulating SbPAL1, SbPAL2, SbPAL3, SbC4H, Sb4CL, SbCHI, and UBGAT, ultimately yielding total flavonoid contents of up to 133 +- 7.66 mg g-1 dry weight, which was 532% greater than the average value of total flavonoid contents produced by three GUS-overexpressing lines.	Flavonoids	74-83	phosphatidic acid phosphatase 1	Arabidopsis thaliana	48-52
33486093-3	2021	Similarly, the Arabidopsis transcription factor PAP1 was found to enhance flavonoid accumulation by upregulating SbPAL1, SbPAL2, SbPAL3, SbC4H, Sb4CL, SbCHI, and UBGAT, ultimately yielding total flavonoid contents of up to 133 +- 7.66 mg g-1 dry weight, which was 532% greater than the average value of total flavonoid contents produced by three GUS-overexpressing lines.	Flavonoids	195-204	phosphatidic acid phosphatase 1	Arabidopsis thaliana	48-52
33486093-3	2021	Similarly, the Arabidopsis transcription factor PAP1 was found to enhance flavonoid accumulation by upregulating SbPAL1, SbPAL2, SbPAL3, SbC4H, Sb4CL, SbCHI, and UBGAT, ultimately yielding total flavonoid contents of up to 133 +- 7.66 mg g-1 dry weight, which was 532% greater than the average value of total flavonoid contents produced by three GUS-overexpressing lines.	Flavonoids	195-204	phosphatidic acid phosphatase 1	Arabidopsis thaliana	48-52
33486093-5	2021	These results also indicate that ZmLc and AtPAP1 can be used as positive regulators of the flavonoid biosynthetic pathway of S. baicalensis hairy root cultures.	Flavonoids	91-100	phosphatidic acid phosphatase 1	Arabidopsis thaliana	42-48
33377988-7	2021	The flavonoid 7,8-dihydroxyflavone (7,8-DHF) acts as a highly affine-selective TrkB receptor agonist and causes the dimerization and autophosphorylation of the TrkB receptor and thus the activation of downstream signaling pathways.	Flavonoids	4-13	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	79-83
33377988-7	2021	The flavonoid 7,8-dihydroxyflavone (7,8-DHF) acts as a highly affine-selective TrkB receptor agonist and causes the dimerization and autophosphorylation of the TrkB receptor and thus the activation of downstream signaling pathways.	Flavonoids	4-13	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	160-164
33618628-2	2021	Therefore, we investigate the inhibitory activity of a group of dietary bioactive flavonoids against SARS-CoV-2 main protease (Mpro), which are identified as one of the potential targets in the drug discovery process of COVID-19.	Flavonoids	82-92	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	127-131
33618628-3	2021	After the initial virtual screening of a number of bioactive flavonoids, the binding affinity of three compounds - Naringin, Naringenin and Amentoflavone - at the active site of Mpro was investigated through MD Simulations, MM-PBSA and DFT Binding Energy calculations.	Flavonoids	61-71	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	178-182
33568298-2	2021	WRKY11 promotes the biosynthesis of flavonoids in apple, but the molecular mechanism of WRKY11 regulating flavonols biosynthesis, and whether WRKY11 plays the same roles in other plants species remains to be further studied.	Flavonoids	36-46	probable WRKY transcription factor 7	Malus domestica	0-6
33652665-5	2021	It was found that every combined administration of a flavonoid and methyldopa in these cells induced a down-regulating effect on all tested factors, except PIGF, especially at the mRNA expression level.	Flavonoids	53-62	phosphatidylinositol glycan anchor biosynthesis class F	Homo sapiens	156-160
33594109-8	2021	In the resistant cultivar, DEGs encoding CYP450, TCM, CCoAOMT, 4CL, PAL, CCR, CSE, and CADH, involved in the synthesis of plant antitoxins such as flavonoids, stilbenoids, and lignins, enriched in the phenylpropane pathway were upregulated at 3 and 7 dpi.	Flavonoids	147-157	phenylalanine ammonia-lyase	Nicotiana tabacum	68-71
33345858-2	2021	The current study explored the potential of some less-studied flavonoids in inhibiting Matrix Metalloproteinase-9 (MMP-9), a prominent biomarker, upregulated in a variety of cancers and known to promote migration and invasion of cancer cells.	Flavonoids	62-72	matrix metallopeptidase 9	Homo sapiens	87-113
33092006-3	2021	Thin layer chromatography combined with surface enhanced Raman spectroscopy (TLC-SERS) was established to simultaneously separate and detect 14 citrus flavonoids for the first time.	Flavonoids	151-161	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	81-85
33092006-6	2021	Moreover, the established TLC-SERS method was successfully used to simultaneously detect multiple flavonoids in real samples, which exhibited comparable accuracy to high performance liquid chromatography with shorter analytical time (10 vs 45 min).	Flavonoids	98-108	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	30-34
33345858-2	2021	The current study explored the potential of some less-studied flavonoids in inhibiting Matrix Metalloproteinase-9 (MMP-9), a prominent biomarker, upregulated in a variety of cancers and known to promote migration and invasion of cancer cells.	Flavonoids	62-72	matrix metallopeptidase 9	Homo sapiens	115-120
33345858-3	2021	Amongst these, Tamarixetin, a naturally occurring flavonoid derivative of Quercetin, demonstrated significant dose-dependent inhibition of MMP-9 expression.	Flavonoids	50-59	matrix metallopeptidase 9	Homo sapiens	139-144
33572002-11	2021	Our data suggest that total flavonoids of B. pilosa attenuate collagen-induced arthritis by suppressing the receptor activator of nuclear factor-kappaB ligand/receptor activator of nuclear factor-kappaB/osteoprotegerin pathway and the subsequent production of proinflammatory cytokines.	Flavonoids	28-38	TNF receptor superfamily member 11B	Rattus norvegicus	203-218
33439200-0	2021	Citrus peel flavonoid nobiletin alleviates lipopolysaccharide-induced inflammation by activating IL-6/STAT3/FOXO3a-mediated autophagy.	Flavonoids	12-21	interleukin 6	Mus musculus	97-101
33439200-0	2021	Citrus peel flavonoid nobiletin alleviates lipopolysaccharide-induced inflammation by activating IL-6/STAT3/FOXO3a-mediated autophagy.	Flavonoids	12-21	forkhead box O3	Mus musculus	108-114
33573609-0	2021	Retraction Note: Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines.	Flavonoids	17-27	ATP binding cassette subfamily B member 1	Homo sapiens	83-97
33554619-0	2022	A comprehensive review on the antidiabetic activity of flavonoids targeting PTP1B and DPP-4: a structure-activity relationship analysis.	Flavonoids	55-65	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	76-81
33782649-3	2021	Numerous in vitro and in vivo studies have shown that flavonoids can act within processes and pathways relevant to AD, such as Abeta and tau pathology, increases in BDNF, inflammation, oxidative stress and neurogenesis.	Flavonoids	54-64	amyloid beta precursor protein	Homo sapiens	127-132
33782649-3	2021	Numerous in vitro and in vivo studies have shown that flavonoids can act within processes and pathways relevant to AD, such as Abeta and tau pathology, increases in BDNF, inflammation, oxidative stress and neurogenesis.	Flavonoids	54-64	microtubule associated protein tau	Homo sapiens	137-140
33782649-3	2021	Numerous in vitro and in vivo studies have shown that flavonoids can act within processes and pathways relevant to AD, such as Abeta and tau pathology, increases in BDNF, inflammation, oxidative stress and neurogenesis.	Flavonoids	54-64	brain derived neurotrophic factor	Homo sapiens	165-169
33782649-6	2021	Given the current lack of success of anti-Abeta targeting therapeutics, particular attention will be given to flavonoid-mediated regulation of tau phosphorylation and aggregation, where there is a comparable lack of study.	Flavonoids	110-119	microtubule associated protein tau	Homo sapiens	143-146
33554619-7	2022	We intend to provide the most favorable chemical features of flavonoids for the inhibition of PTP1B and DPP-4, gathering information for the future development of compounds with improved potential as T2D therapeutic agents.	Flavonoids	61-71	dipeptidyl peptidase 4	Homo sapiens	104-109
33554619-0	2022	A comprehensive review on the antidiabetic activity of flavonoids targeting PTP1B and DPP-4: a structure-activity relationship analysis.	Flavonoids	55-65	dipeptidyl peptidase 4	Homo sapiens	86-91
33554619-6	2022	In the present study, a comprehensive review of the literature of both synthetic and natural isolated flavonoids as inhibitors of PTP1B and DPP-4 activities is made, including their type of inhibition and experimental conditions, and structure-activity relationship, covering a total of 351 compounds.	Flavonoids	102-112	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	130-135
33554619-6	2022	In the present study, a comprehensive review of the literature of both synthetic and natural isolated flavonoids as inhibitors of PTP1B and DPP-4 activities is made, including their type of inhibition and experimental conditions, and structure-activity relationship, covering a total of 351 compounds.	Flavonoids	102-112	dipeptidyl peptidase 4	Homo sapiens	140-145
33554619-7	2022	We intend to provide the most favorable chemical features of flavonoids for the inhibition of PTP1B and DPP-4, gathering information for the future development of compounds with improved potential as T2D therapeutic agents.	Flavonoids	61-71	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	94-99
33628187-3	2020	This study aims to find efficacious UGT1A1 inducer(s) from natural flavonoids, and to reveal the mechanism involved in up-regulating of this key conjugative enzyme by the flavonoid(s) with strong UGT1A1 induction activity.	Flavonoids	67-77	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	36-42
33554773-2	2021	The aim of this work is to identify and investigate the inhibition mechanism of natural flavonoids and phenolics acids against, the alpha-amylase (alphaA) and alpha-glucosidase (alphaG).	Flavonoids	88-98	sucrase-isomaltase	Homo sapiens	159-176
33628187-3	2020	This study aims to find efficacious UGT1A1 inducer(s) from natural flavonoids, and to reveal the mechanism involved in up-regulating of this key conjugative enzyme by the flavonoid(s) with strong UGT1A1 induction activity.	Flavonoids	67-76	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	196-202
33628187-3	2020	This study aims to find efficacious UGT1A1 inducer(s) from natural flavonoids, and to reveal the mechanism involved in up-regulating of this key conjugative enzyme by the flavonoid(s) with strong UGT1A1 induction activity.	Flavonoids	67-77	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	196-202
33628187-3	2020	This study aims to find efficacious UGT1A1 inducer(s) from natural flavonoids, and to reveal the mechanism involved in up-regulating of this key conjugative enzyme by the flavonoid(s) with strong UGT1A1 induction activity.	Flavonoids	67-76	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	36-42
33017787-0	2021	Influence of antioxidant flavonoids quercetin and rutin on the in-vitro binding of neratinib to human serum albumin.	Flavonoids	25-35	albumin	Homo sapiens	102-115
33261954-9	2021	Flavonoid and saponin, two types of compounds in YPFG, were found to be the major active ingredients in the immunomodulatory effects of YPFG, and these components may regulate the abnormal metabolism of bile acids by enhancing the expression of FXR and LXRalpha.	Flavonoids	0-9	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	245-248
33261954-9	2021	Flavonoid and saponin, two types of compounds in YPFG, were found to be the major active ingredients in the immunomodulatory effects of YPFG, and these components may regulate the abnormal metabolism of bile acids by enhancing the expression of FXR and LXRalpha.	Flavonoids	0-9	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	253-261
33017787-7	2021	Interaction of NRB with HSA in presence of quercetin and rutin resulted in changes in the binding constants of HSA-NRB suggesting some impact on the binding of NRB in the presence of flavonoids.	Flavonoids	183-193	albumin	Homo sapiens	24-27
33017787-7	2021	Interaction of NRB with HSA in presence of quercetin and rutin resulted in changes in the binding constants of HSA-NRB suggesting some impact on the binding of NRB in the presence of flavonoids.	Flavonoids	183-193	albumin	Homo sapiens	111-114
33017787-1	2021	This study was designed to examine the interaction of neratinib (NRB) with human serum albumin (HSA) in presence of flavonoids quercetin and rutin.	Flavonoids	116-126	albumin	Homo sapiens	81-94
33017787-1	2021	This study was designed to examine the interaction of neratinib (NRB) with human serum albumin (HSA) in presence of flavonoids quercetin and rutin.	Flavonoids	116-126	albumin	Homo sapiens	96-99
33538672-9	2021	In this review, we have summarised the potential of phytochemicals especially the category of flavonoids, alkaloids, glycosides, terpenoids, and coumarin as the available-affordable-safe-effective repositories of VEGF inhibitors.	Flavonoids	94-104	vascular endothelial growth factor A	Homo sapiens	213-217
33450548-2	2021	Herein, a series of flavonol-based derivatives of fisetin, a plant-based flavonoid identified as an anti-tumorigenic agent targeting the mammalian targets of rapamycin (mTOR)-regulated pathways, were synthesized and fully characterized.	Flavonoids	73-82	mechanistic target of rapamycin kinase	Homo sapiens	169-173
33494250-12	2021	The relationship between the activity index or proportion of POD activity in the scutellum and the changes in the flavonoid concentration is proposed as a marker of stress and the state of vigor of the embryo.	Flavonoids	114-123	peroxidase 1	Zea mays	61-64
32770567-6	2021	In the current study we demonstrated by bioinformatics (CASTp: computed atlas of surface topography of protein, PyMol: molecular visualization) and molecular docking (PatchDock and Autodock) experiments that tea flavonoids catechin products mainly epigallocatechin gallate or other like theaflavin gallate demonstrated higher atomic contact energy (ACE) value, binding energy, Ki value, ligand efficiency, surface area and more amino acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike protein.	Flavonoids	212-222	calpastatin	Homo sapiens	56-61
32770567-6	2021	In the current study we demonstrated by bioinformatics (CASTp: computed atlas of surface topography of protein, PyMol: molecular visualization) and molecular docking (PatchDock and Autodock) experiments that tea flavonoids catechin products mainly epigallocatechin gallate or other like theaflavin gallate demonstrated higher atomic contact energy (ACE) value, binding energy, Ki value, ligand efficiency, surface area and more amino acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike protein.	Flavonoids	212-222	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	527-532
33340783-0	2021	Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFbeta/SMAD3 and JAK2/STAT3 signaling.	Flavonoids	8-17	transforming growth factor alpha	Mus musculus	95-102
33340783-0	2021	Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFbeta/SMAD3 and JAK2/STAT3 signaling.	Flavonoids	8-17	SMAD family member 3	Mus musculus	103-108
33340783-0	2021	Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFbeta/SMAD3 and JAK2/STAT3 signaling.	Flavonoids	8-17	Janus kinase 2	Mus musculus	113-117
33340783-0	2021	Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFbeta/SMAD3 and JAK2/STAT3 signaling.	Flavonoids	8-17	signal transducer and activator of transcription 3	Mus musculus	118-123
33448034-0	2021	Garlic flavonoids alleviate H2 O2 induced oxidative damage in L02 cells and induced apoptosis in HepG2 cells by Bcl-2/Caspase pathway.	Flavonoids	7-17	BCL2 apoptosis regulator	Homo sapiens	112-117
33448034-9	2021	Moreover, the flavonoids could induce apoptosis in HepG2 cells via Bcl-2/Caspase pathways, where it could up-regulate the expression of Bax and down-regulate the expression of Bcl-2, Bcl-xL, pro-Caspase-3, and pro-Caspase-9 proteins in a dose dependent manner.	Flavonoids	14-24	BCL2 apoptosis regulator	Homo sapiens	67-72
33448034-9	2021	Moreover, the flavonoids could induce apoptosis in HepG2 cells via Bcl-2/Caspase pathways, where it could up-regulate the expression of Bax and down-regulate the expression of Bcl-2, Bcl-xL, pro-Caspase-3, and pro-Caspase-9 proteins in a dose dependent manner.	Flavonoids	14-24	BCL2 associated X, apoptosis regulator	Homo sapiens	136-139
33448034-9	2021	Moreover, the flavonoids could induce apoptosis in HepG2 cells via Bcl-2/Caspase pathways, where it could up-regulate the expression of Bax and down-regulate the expression of Bcl-2, Bcl-xL, pro-Caspase-3, and pro-Caspase-9 proteins in a dose dependent manner.	Flavonoids	14-24	BCL2 apoptosis regulator	Homo sapiens	176-181
33448034-9	2021	Moreover, the flavonoids could induce apoptosis in HepG2 cells via Bcl-2/Caspase pathways, where it could up-regulate the expression of Bax and down-regulate the expression of Bcl-2, Bcl-xL, pro-Caspase-3, and pro-Caspase-9 proteins in a dose dependent manner.	Flavonoids	14-24	BCL2 like 1	Homo sapiens	183-189
33448034-9	2021	Moreover, the flavonoids could induce apoptosis in HepG2 cells via Bcl-2/Caspase pathways, where it could up-regulate the expression of Bax and down-regulate the expression of Bcl-2, Bcl-xL, pro-Caspase-3, and pro-Caspase-9 proteins in a dose dependent manner.	Flavonoids	14-24	caspase 3	Homo sapiens	191-204
33448034-11	2021	PRACTICAL APPLICATION: Flavonoids from Laba garlic showed selective toxicity towards HepG2 cells in comparison to L02 cells via regulating Bcl-2/caspase pathway.	Flavonoids	23-33	BCL2 apoptosis regulator	Homo sapiens	139-144
33487344-4	2021	Although various studies indicate at the involvement of an E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) and ELONGATED HYPOCOTYL 5 (HY5) in flavonoid biosynthesis in response to UV-B, the regulatory roles of these components under visible light are yet to be investigated.	Flavonoids	153-162	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	79-110
33510287-12	2021	An MTT assay and quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting analyses demonstrated that the flavonoids of SCST revealed anti-hepatic fibrosis effects via anti-proliferation and increases in the Stat1, Pparg, Hsp90aa1 genes and STAT1 and PPARG proteins in LX-2 cells.	Flavonoids	128-138	signal transducer and activator of transcription 1	Homo sapiens	230-235
33510287-12	2021	An MTT assay and quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting analyses demonstrated that the flavonoids of SCST revealed anti-hepatic fibrosis effects via anti-proliferation and increases in the Stat1, Pparg, Hsp90aa1 genes and STAT1 and PPARG proteins in LX-2 cells.	Flavonoids	128-138	peroxisome proliferator activated receptor gamma	Homo sapiens	237-242
33510287-12	2021	An MTT assay and quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting analyses demonstrated that the flavonoids of SCST revealed anti-hepatic fibrosis effects via anti-proliferation and increases in the Stat1, Pparg, Hsp90aa1 genes and STAT1 and PPARG proteins in LX-2 cells.	Flavonoids	128-138	heat shock protein 90 alpha family class A member 1	Homo sapiens	244-252
33510287-12	2021	An MTT assay and quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting analyses demonstrated that the flavonoids of SCST revealed anti-hepatic fibrosis effects via anti-proliferation and increases in the Stat1, Pparg, Hsp90aa1 genes and STAT1 and PPARG proteins in LX-2 cells.	Flavonoids	128-138	signal transducer and activator of transcription 1	Homo sapiens	263-268
33510287-12	2021	An MTT assay and quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting analyses demonstrated that the flavonoids of SCST revealed anti-hepatic fibrosis effects via anti-proliferation and increases in the Stat1, Pparg, Hsp90aa1 genes and STAT1 and PPARG proteins in LX-2 cells.	Flavonoids	128-138	peroxisome proliferator activated receptor gamma	Homo sapiens	273-278
33504301-0	2021	Phenylbenzopyrone of flavonoids as a potential scaffold to prevent SARS-CoV-2 replication by inhibiting its MPRO main protease.	Flavonoids	21-31	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	108-112
33383321-0	2021	pH-promoted O-alpha-glucosylation of flavonoids using an engineered alpha-glucosidase mutant.	Flavonoids	37-47	ABC transporter permease	Saccharolobus solfataricus	68-85
33383321-3	2021	In this study, an efficient O-alpha-glucosylation of flavonoids was developed using an O-alpha-glycoligase derived from a thermostable alpha-glucosidase from Sulfolobus solfataricus (MalA-D416A).	Flavonoids	53-63	ABC transporter permease	Saccharolobus solfataricus	135-152
31900044-0	2021	Non-enzymatic glycation of human serum albumin modulates its binding efficacy towards bioactive flavonoid chrysin: A detailed study using multi-spectroscopic and computational methods.	Flavonoids	96-105	albumin	Homo sapiens	33-46
31900044-4	2021	The aim of the present study is to determine the effect of glycation on the binding of human serum albumin (HSA) with bioactive flavonoid chrysin, which possesses anti-cancer, anti-inflammatory and anti-oxidant activities.	Flavonoids	128-137	albumin	Homo sapiens	93-106
33339654-2	2021	Icariin, a bone bioactive flavonoid, has been reported to selectively activate non-genomic ERalpha signaling in in vitro and in vivo studies.	Flavonoids	26-35	estrogen receptor 1	Rattus norvegicus	91-98
33870156-5	2021	Mdr2 -/- mice were also treated with fisetin, a flavonoid molecule that selectively kills senescent cells.	Flavonoids	48-57	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-4
33551818-9	2020	The experimental validation data showed that the flavonoids from AR were able to suppress transforming growth factor beta 1 (TGF-beta1)-mediated activation of hepatic stellate cells (HSCs) and reduce extracellular matrix deposition in HSC-T6 cells via regulating the nuclear factor kappa B (NF-kappaB) signal transduction pathway.	Flavonoids	49-59	transforming growth factor, beta 1	Rattus norvegicus	90-123
33551818-9	2020	The experimental validation data showed that the flavonoids from AR were able to suppress transforming growth factor beta 1 (TGF-beta1)-mediated activation of hepatic stellate cells (HSCs) and reduce extracellular matrix deposition in HSC-T6 cells via regulating the nuclear factor kappa B (NF-kappaB) signal transduction pathway.	Flavonoids	49-59	transforming growth factor, beta 1	Rattus norvegicus	125-134
32700448-4	2021	PR10/Bet v 1-like proteins participate in the production of plant alkaloids and phenolics including flavonoids, both as general binding proteins and in special cases as catalysts.	Flavonoids	100-110	delta/notch like EGF repeat containing	Homo sapiens	5-8
33271149-3	2021	Here we report identification of Kaempferol, a dietary flavonoid, as a potent Nrf2 inhibitor using Nrf2 reporter assay in NSCLC cells (A549 and NCIH460).	Flavonoids	55-64	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
33271149-3	2021	Here we report identification of Kaempferol, a dietary flavonoid, as a potent Nrf2 inhibitor using Nrf2 reporter assay in NSCLC cells (A549 and NCIH460).	Flavonoids	55-64	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
33393294-0	2021	Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.	Flavonoids	26-35	fms related receptor tyrosine kinase 3	Homo sapiens	58-62
33393294-6	2021	In this study, several plant-derived flavonoids have been identified with FLT3 inhibitory activity.	Flavonoids	37-47	fms related receptor tyrosine kinase 3	Homo sapiens	74-78
33393294-10	2021	Collectively, these flavonoids have the potential to be further optimized as FLT3 inhibitors and provide valuable chemical information for the development of new AML drugs.	Flavonoids	20-30	fms related receptor tyrosine kinase 3	Homo sapiens	77-81
33442914-9	2022	Studies conducted on cells treated with flavonoids and ionizing radiation showed that the moderate increase in ROS levels in the flavonoid treated groups corresponded with higher PTEN levels and lowered Akt levels leading to a higher occurrence of autophagy.	Flavonoids	40-50	phosphatase and tensin homolog	Homo sapiens	179-183
33442914-9	2022	Studies conducted on cells treated with flavonoids and ionizing radiation showed that the moderate increase in ROS levels in the flavonoid treated groups corresponded with higher PTEN levels and lowered Akt levels leading to a higher occurrence of autophagy.	Flavonoids	40-50	AKT serine/threonine kinase 1	Homo sapiens	203-206
33442914-9	2022	Studies conducted on cells treated with flavonoids and ionizing radiation showed that the moderate increase in ROS levels in the flavonoid treated groups corresponded with higher PTEN levels and lowered Akt levels leading to a higher occurrence of autophagy.	Flavonoids	40-49	phosphatase and tensin homolog	Homo sapiens	179-183
33442914-9	2022	Studies conducted on cells treated with flavonoids and ionizing radiation showed that the moderate increase in ROS levels in the flavonoid treated groups corresponded with higher PTEN levels and lowered Akt levels leading to a higher occurrence of autophagy.	Flavonoids	40-49	AKT serine/threonine kinase 1	Homo sapiens	203-206
33100126-1	2021	The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is a well-established transcriptional activator of genes required for anthocyanin and flavonoid production, and a repressor of lignin and other secondary cell wall biosynthesis genes.	Flavonoids	168-177	production of anthocyanin pigment 1	Arabidopsis thaliana	37-62
33427491-0	2022	Flavonoids as potential agents in the management of type 2 diabetes through the modulation of alpha-amylase and alpha-glucosidase activity: a review.	Flavonoids	0-10	sucrase-isomaltase	Homo sapiens	112-129
33427491-6	2022	The aim of this review is to provide an overview on the scientific literature concerning the structure-activity relationship of flavonoids in inhibiting alpha-amylase and alpha-glucosidase, including their type of inhibition and experimental procedures applied.	Flavonoids	128-138	sucrase-isomaltase	Homo sapiens	171-188
33510742-8	2020	Moreover, the treatment with fragmented DNA 100 mug mL-1 showed significant increase in the content of phenolic compounds and total flavonoids as well as gene expression associated to plant defense in comparison with control plants.	Flavonoids	132-142	L1 cell adhesion molecule	Mus musculus	52-56
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Flavonoids	64-74	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	174-178
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Flavonoids	64-74	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	181-186
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Flavonoids	64-74	angiotensin I converting enzyme	Homo sapiens	196-225
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Flavonoids	64-74	dipeptidyl peptidase 4	Homo sapiens	269-273
33430420-3	2021	We tested, for the first time in TGCT cell lines, a new synthetic flavonoid compound (MLo1302) from the 3-nitroflavanone family of DNA methyltransferase (DNMT) inhibitors.	Flavonoids	66-75	DNA methyltransferase 1	Homo sapiens	131-152
33430420-3	2021	We tested, for the first time in TGCT cell lines, a new synthetic flavonoid compound (MLo1302) from the 3-nitroflavanone family of DNA methyltransferase (DNMT) inhibitors.	Flavonoids	66-75	DNA methyltransferase 1	Homo sapiens	154-158
33402173-2	2021	Isoliquiritin is a phenolic flavonoid compound that has been demonstrated to suppress NLRP3-mediated pyroptosis.	Flavonoids	28-37	NLR family pyrin domain containing 3	Homo sapiens	86-91
33401572-0	2021	Flavonoids Targeting HIF-1: Implications on Cancer Metabolism.	Flavonoids	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-26
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-100
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	pyruvate kinase M1/2	Homo sapiens	213-217
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	lactate dehydrogenase A	Homo sapiens	220-241
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	lactate dehydrogenase A	Homo sapiens	243-247
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	hexokinase 2	Homo sapiens	280-293
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	hexokinase 2	Homo sapiens	295-299
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	phosphofructokinase, muscle	Homo sapiens	302-323
33401572-7	2021	Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK).	Flavonoids	45-55	phosphofructokinase, muscle	Homo sapiens	325-330
33401572-8	2021	Here, we discuss the results of most recent studies evaluating the impact of flavonoids on HIF-1 accompanied by the regulation of critical enzymes contributing to the Warburg phenotype.	Flavonoids	77-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-96
33401572-9	2021	Besides, flavonoid effects on glucose metabolism via regulation of HIF-1 activity represent a promising avenue in cancer-related research.	Flavonoids	9-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
33100126-1	2021	The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is a well-established transcriptional activator of genes required for anthocyanin and flavonoid production, and a repressor of lignin and other secondary cell wall biosynthesis genes.	Flavonoids	168-177	production of anthocyanin pigment 1	Arabidopsis thaliana	64-69
32819237-0	2021	The Natural Flavonoid Naringenin Inhibits the Cell Growth of WilmsTumorinChildren by Suppressing TLR4/NF-kappaB Signaling.	Flavonoids	12-21	toll like receptor 4	Homo sapiens	97-101
33642550-1	2021	Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, a citrus flavonoid.	Flavonoids	79-88	growth hormone	Mus musculus	21-23
32129166-5	2021	This plant contains flavonoids which can inhibit the COX-2 enzyme.	Flavonoids	20-30	cox2	Allium cepa	53-58
32819237-0	2021	The Natural Flavonoid Naringenin Inhibits the Cell Growth of WilmsTumorinChildren by Suppressing TLR4/NF-kappaB Signaling.	Flavonoids	12-21	nuclear factor kappa B subunit 1	Homo sapiens	102-111
31657688-0	2021	In silico identification of novel flavonoids targeting epidermal growth factor receptor.	Flavonoids	34-44	epidermal growth factor receptor	Homo sapiens	55-87
31657688-4	2021	OBJECTIVE: In this study we performed virtual screening of 329 flavonoids obtained from Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target (NPACT) database to identify novel EGFR inhibitors.	Flavonoids	63-73	epidermal growth factor receptor	Homo sapiens	192-196
31657688-6	2021	RESULTS: Six flavonoids NPACT00061, NPACT00062, NPACT00066, NPACT00280, NPACT00700 and NPACT00856 were identified as potential EGFR inhibitors with good docking score and druglikeness properties.	Flavonoids	13-23	epidermal growth factor receptor	Homo sapiens	127-131
31657688-8	2021	Finally, two flavonoids NPACT00280 and NPACT00700 were recognized as novel EGFR inhibitors.	Flavonoids	13-23	epidermal growth factor receptor	Homo sapiens	75-79
33363251-3	2021	Molecular docking studies for 15 flavonoids on the three SARS CoV-2 proteins, non-structural protein-15 Endoribonuclease (NSP15), the receptor-binding domain of spike protein (RBD of S protein), and main protease (Mpro/3CLpro) were performed and selected protein-ligand complexes were subjected to Molecular Dynamics simulations.	Flavonoids	33-43	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	161-166
33363251-3	2021	Molecular docking studies for 15 flavonoids on the three SARS CoV-2 proteins, non-structural protein-15 Endoribonuclease (NSP15), the receptor-binding domain of spike protein (RBD of S protein), and main protease (Mpro/3CLpro) were performed and selected protein-ligand complexes were subjected to Molecular Dynamics simulations.	Flavonoids	33-43	rbd of s protein), and main protease	None	176-212
33363251-3	2021	Molecular docking studies for 15 flavonoids on the three SARS CoV-2 proteins, non-structural protein-15 Endoribonuclease (NSP15), the receptor-binding domain of spike protein (RBD of S protein), and main protease (Mpro/3CLpro) were performed and selected protein-ligand complexes were subjected to Molecular Dynamics simulations.	Flavonoids	33-43	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	214-218
33390788-0	2021	Inhibition of human amylin aggregation by Flavonoid Chrysin: An in-silico and in-vitro approach.	Flavonoids	42-51	islet amyloid polypeptide	Homo sapiens	20-26
33390788-5	2021	Several flavonoids have inhibitory effects on amylin amyloidosis, but its inhibition mechanisms are unknown.	Flavonoids	8-18	islet amyloid polypeptide	Homo sapiens	46-52
33545843-9	2021	The innovative hydrogel HGNC-Phl promoted a drug-reservoir in the stratum corneum and higher penetration of the flavonoid into the epidermis.	Flavonoids	112-121	BCR activator of RhoGEF and GTPase	Homo sapiens	29-32
33759122-8	2021	Furthermore, herein is described the docking process of calf thymus DNA with three metal complexes, as a potential metallo-therapeutics as also the docking process of the plant flavonoid quercetin to the antiapoptotic protein BcL-xL.	Flavonoids	177-186	BCL2 like 1	Bos taurus	226-232
33154094-5	2021	In addition, flavonoids stimulate rhodopsin gene expression.	Flavonoids	13-23	rhodopsin	Mus musculus	34-43
32735533-10	2021	CONCLUSION: LNCs of NGR enhance solubility and intestinal permeability of this flavonoid and may be useful in improvement of its bioavailability.	Flavonoids	79-88	reticulon 4 receptor	Rattus norvegicus	20-23
33091854-0	2021	Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFkappaB signaling pathway.	Flavonoids	6-16	mitogen-activated protein kinase 8	Mus musculus	158-161
33091854-0	2021	Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFkappaB signaling pathway.	Flavonoids	6-16	thymoma viral proto-oncogene 1	Mus musculus	162-165
33091854-0	2021	Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFkappaB signaling pathway.	Flavonoids	6-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-174
32344402-10	2021	Finally, flavonoids sophoranone treatment also increased gene expressions of Myh3, Myog and MCK.	Flavonoids	9-19	myosin, heavy polypeptide 3, skeletal muscle, embryonic	Mus musculus	77-81
32344402-10	2021	Finally, flavonoids sophoranone treatment also increased gene expressions of Myh3, Myog and MCK.	Flavonoids	9-19	myogenin	Mus musculus	83-87
32344402-10	2021	Finally, flavonoids sophoranone treatment also increased gene expressions of Myh3, Myog and MCK.	Flavonoids	9-19	creatine kinase, muscle	Mus musculus	92-95
33424398-0	2021	In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2.	Flavonoids	24-34	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	72-77
33424398-4	2021	In the current study, an in silico approach is carried out as a means of inhibiting the spike protein of the novel coronavirus by flavonoids from natural sources that possess both antiviral and anti-inflammatory properties.	Flavonoids	130-140	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	88-93
33424398-5	2021	The methodology is focused on molecular docking of 10 flavonoid compounds that are docked with the spike protein of SARS-CoV-2, to determine the highest binding affinity at the binding site.	Flavonoids	54-63	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	99-104
33110386-0	2021	Computational selection of flavonoid compounds as inhibitors against SARS-CoV-2 main protease, RNA-dependent RNA polymerase and spike proteins: A molecular docking study.	Flavonoids	27-36	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	128-133
33424398-7	2021	The flavonoid naringin showed the least binding energy of -9.8 Kcal/mol with the spike protein which was compared with the standard drug, dexamethasone which is being repurposed to treat critically ill patients.	Flavonoids	4-13	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	81-86
33320670-7	2020	Interestingly, a natural flavonoid binds SARS-CoV-2 Mpro in the close proximity to a conserved cysteine (Cys44), which is hyper-reactive according to the CpHMD titration.	Flavonoids	25-34	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	52-56
33505939-1	2020	The objective of this study was to investigate characterization of inclusion complexes of flavonoids with hydroxypropyl-beta-cyclodextrin (HP-beta-CD).	Flavonoids	90-100	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	142-149
33505939-2	2020	The inclusion complexes of flavonoids with HP-beta-CD was prepared by the freeze-drying method and its characterization was investigated by different analytical techniques including ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry, and X-ray diffractometry.	Flavonoids	27-37	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	46-53
33505939-6	2020	The melting point of flavonoids disappeared, and the thermal properties of HP-beta-CD were altered following formation of the inclusion complex between flavonoids and HP-beta-CD, resulting in a shift in the melting peak.	Flavonoids	152-162	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
33008592-5	2020	Among all tested flavonoids, quercetin was the most potent inhibitor for HCN channels with an IC50 value of 27.32 +- 1.19 muM for HCN2.	Flavonoids	17-27	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	130-134
32999131-0	2020	Ethyl acetate fraction of flavonoids from Polygonum hydropiper L. modulates pseudorabies virus-induced inflammation in RAW264.7 cells via the NF-kappaB and MAPK pathways.	Flavonoids	26-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
33352581-7	2021	LCMS profiling of the F. glaucescens revealed its high content of flavonoids, a known micheal acceptor with possible NQO-1 induction, as proved by quantitative high-performance liquid chromatography analysis.	Flavonoids	66-76	NAD(P)H dehydrogenase, quinone 1	Mus musculus	117-122
33058977-0	2020	Protective actions of bioactive flavonoids chrysin and luteolin on the glyoxal induced formation of advanced glycation end products and aggregation of human serum albumin: In vitro and molecular docking analysis.	Flavonoids	32-42	albumin	Homo sapiens	157-170
33185419-4	2020	This study comprehensively assesses the inhibitory properties of two small molecules, the lignan polyphenol honokiol and the flavonoid 2",3",4"-trihydroxyflavone, in preventing alpha-synuclein fibrilization.	Flavonoids	125-134	synuclein alpha	Homo sapiens	177-192
32866894-0	2020	Effect of total flavonoids of Rhizoma Drynariae in thiram induced cytotoxicity of chondrocyte via BMP-2/Runx2 and IHH/PTHrP expressions.	Flavonoids	16-26	bone morphogenetic protein 2	Homo sapiens	98-103
32866894-0	2020	Effect of total flavonoids of Rhizoma Drynariae in thiram induced cytotoxicity of chondrocyte via BMP-2/Runx2 and IHH/PTHrP expressions.	Flavonoids	16-26	Indian hedgehog signaling molecule	Homo sapiens	114-117
33122058-0	2020	Multi-spectroscopic investigation, molecular docking and molecular dynamic simulation of competitive interactions between flavonoids (quercetin and rutin) and sorafenib for binding to human serum albumin.	Flavonoids	122-132	albumin	Homo sapiens	190-203
33010267-0	2020	Flavonoids as BACE1 inhibitors: QSAR modelling, screening and in vitro evaluation.	Flavonoids	0-10	beta-secretase 1	Homo sapiens	14-19
33122058-2	2020	The aim of this study was to evaluate anticancer drug sorafenib displacement from the binding site on human serum albumin by commonly used plant flavonoids quercetin and rutin.	Flavonoids	145-155	albumin	Homo sapiens	108-121
33290200-4	2021	RESULTS: Flavonoids reduces complications in addition to its vital role as effective supplements for preventing diabetes mellitus by regulating glucose metabolism, lipid profile, liver enzyme activity, a protein kinase inhibitor, PPAR, AMPK with NF-kappaB Conclusion: Articles that we reviewed showed the positive role of flavonoids, which at a certain way reduce diabetes, but its side effects are still missing, this review focus on the different type of dietary flavonoids along with their mechanism in reducing blood glucose and enhance insulin sensitivity as well as some side effects.	Flavonoids	9-19	peroxisome proliferator activated receptor alpha	Homo sapiens	230-234
33363176-3	2020	Quercetin, a natural flavonoid possessing a specific effect of autophagy stimulation and SIRT1 activation, showed some protective effect on a series of degenerative diseases.	Flavonoids	21-30	sirtuin 1	Rattus norvegicus	89-94
32827907-1	2020	The binding interactions of bovine lactoferrin (BLF) with two flavonoids dihydromyricetin (DMY) and myricetin (MY) were investigated by the multi-spectroscopic, microscale thermophoresis (MST) techniques, molecular docking, and then their antioxidant activities were studied by detection of free radical scavenging activity against DPPH.	Flavonoids	62-72	lactotransferrin	Bos taurus	35-46
33327536-8	2020	Here, we provide strong evidence that coffee compounds, particularly flavonoids, are responsible for scavenging free radicals and longevity in yeast lacking Sod1, Sod2 and Rad52 proteins.	Flavonoids	69-79	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	157-161
33327536-8	2020	Here, we provide strong evidence that coffee compounds, particularly flavonoids, are responsible for scavenging free radicals and longevity in yeast lacking Sod1, Sod2 and Rad52 proteins.	Flavonoids	69-79	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	163-167
33327536-8	2020	Here, we provide strong evidence that coffee compounds, particularly flavonoids, are responsible for scavenging free radicals and longevity in yeast lacking Sod1, Sod2 and Rad52 proteins.	Flavonoids	69-79	recombinase RAD52	Saccharomyces cerevisiae S288C	172-177
33297910-0	2022	Scutellaria barbata flavonoids improve the composited Abeta-induced abnormal changes of glial cells in rats" brain.	Flavonoids	20-30	amyloid beta precursor protein	Rattus norvegicus	54-59
33290200-4	2021	RESULTS: Flavonoids reduces complications in addition to its vital role as effective supplements for preventing diabetes mellitus by regulating glucose metabolism, lipid profile, liver enzyme activity, a protein kinase inhibitor, PPAR, AMPK with NF-kappaB Conclusion: Articles that we reviewed showed the positive role of flavonoids, which at a certain way reduce diabetes, but its side effects are still missing, this review focus on the different type of dietary flavonoids along with their mechanism in reducing blood glucose and enhance insulin sensitivity as well as some side effects.	Flavonoids	9-19	nuclear factor kappa B subunit 1	Homo sapiens	246-255
33290200-4	2021	RESULTS: Flavonoids reduces complications in addition to its vital role as effective supplements for preventing diabetes mellitus by regulating glucose metabolism, lipid profile, liver enzyme activity, a protein kinase inhibitor, PPAR, AMPK with NF-kappaB Conclusion: Articles that we reviewed showed the positive role of flavonoids, which at a certain way reduce diabetes, but its side effects are still missing, this review focus on the different type of dietary flavonoids along with their mechanism in reducing blood glucose and enhance insulin sensitivity as well as some side effects.	Flavonoids	9-19	insulin	Homo sapiens	541-548
33291318-3	2020	In order to identify novel P2X7R antagonists, we carried out virtual screening on a focused compound dataset, including indole derivatives and natural compounds such as caffeic acid phenethyl ester derivatives, flavonoids, and diterpenoids.	Flavonoids	211-221	purinergic receptor P2X 7	Homo sapiens	27-32
33389971-3	2020	For example, mechanistic target of rapamycin (mTOR) inhibitors such as rapamycin, phenols, and flavonoids show antioxidant characteristics, while spermidine induces autophagy.	Flavonoids	95-105	mechanistic target of rapamycin kinase	Homo sapiens	13-44
32758575-2	2020	inhibits HIV-1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF-kappaB pathway.	Flavonoids	73-83	nuclear factor kappa B subunit 1	Homo sapiens	103-112
32413574-12	2020	Docking study suggested good affinity of flavonoids when docked into the binding site of TNF-alpha.	Flavonoids	41-51	tumor necrosis factor	Rattus norvegicus	89-98
33343802-2	2020	Flavonoids have been demonstrated to display anti-inflammatory and antioxidant effects through the induction of HO-1.	Flavonoids	0-10	heme oxygenase 1	Homo sapiens	112-116
33389971-3	2020	For example, mechanistic target of rapamycin (mTOR) inhibitors such as rapamycin, phenols, and flavonoids show antioxidant characteristics, while spermidine induces autophagy.	Flavonoids	95-105	mechanistic target of rapamycin kinase	Homo sapiens	46-50
32661908-5	2020	RESULTS: We demonstrate that all flavonoids investigated inhibit OATP2B1 in the lower micromolar range (IC50 between 1.6 and 14.2 microM), but only the polymethoxyflavones also inhibit OATP1B1 and 1B3 (IC50 between 2.1 and 21 microM).	Flavonoids	33-43	solute carrier organic anion transporter family member 2B1	Homo sapiens	65-72
33197852-0	2020	Flavonoids from Barnebydendron riedelii leaf extract mitigate thioacetamide-induced hepatic encephalopathy in rats: The interplay of NF-kappaB/IL-6 and Nrf2/HO-1 signaling pathways.	Flavonoids	0-10	interleukin 6	Rattus norvegicus	143-147
33197852-0	2020	Flavonoids from Barnebydendron riedelii leaf extract mitigate thioacetamide-induced hepatic encephalopathy in rats: The interplay of NF-kappaB/IL-6 and Nrf2/HO-1 signaling pathways.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	152-156
33197852-0	2020	Flavonoids from Barnebydendron riedelii leaf extract mitigate thioacetamide-induced hepatic encephalopathy in rats: The interplay of NF-kappaB/IL-6 and Nrf2/HO-1 signaling pathways.	Flavonoids	0-10	heme oxygenase 1	Rattus norvegicus	157-161
32661908-5	2020	RESULTS: We demonstrate that all flavonoids investigated inhibit OATP2B1 in the lower micromolar range (IC50 between 1.6 and 14.2 microM), but only the polymethoxyflavones also inhibit OATP1B1 and 1B3 (IC50 between 2.1 and 21 microM).	Flavonoids	33-43	solute carrier organic anion transporter family member 1B1	Homo sapiens	185-200
32661908-6	2020	CONCLUSIONS: All flavonoids investigated might contribute to the intestinal OATP2B1-based interactions with drugs observed with citrus juices or fruits.	Flavonoids	17-27	solute carrier organic anion transporter family member 2B1	Homo sapiens	76-83
33265939-6	2020	The results showed that flavonoids could regulate the inflammatory response and oxidative stress of tumor through some anti-inflammatory mechanisms such as NF-kappaB, so as to realize the anti-tumor effect.	Flavonoids	24-34	nuclear factor kappa B subunit 1	Homo sapiens	156-165
33152472-2	2020	Among the naturally occurring plant flavonoids, Apigenin 7-O-glucoside (AGL) is endowed with anti-inflammatory, anti-oxidant, and anti-cancer activities.	Flavonoids	36-46	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	48-70
33152472-2	2020	Among the naturally occurring plant flavonoids, Apigenin 7-O-glucoside (AGL) is endowed with anti-inflammatory, anti-oxidant, and anti-cancer activities.	Flavonoids	36-46	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	72-75
33045562-6	2020	The presence of this flavonoid in monocyte cultures increased the expression of CD163 and IkappaBalpha and the release of IL-10 and transforming growth factor beta (TGF-beta) in the culture supernatants, polarising these cells from the M1-like profile to the M2-like profile.	Flavonoids	21-30	CD163 molecule	Homo sapiens	80-85
33045562-6	2020	The presence of this flavonoid in monocyte cultures increased the expression of CD163 and IkappaBalpha and the release of IL-10 and transforming growth factor beta (TGF-beta) in the culture supernatants, polarising these cells from the M1-like profile to the M2-like profile.	Flavonoids	21-30	NFKB inhibitor alpha	Homo sapiens	90-102
33045562-6	2020	The presence of this flavonoid in monocyte cultures increased the expression of CD163 and IkappaBalpha and the release of IL-10 and transforming growth factor beta (TGF-beta) in the culture supernatants, polarising these cells from the M1-like profile to the M2-like profile.	Flavonoids	21-30	interleukin 10	Homo sapiens	122-127
33045562-6	2020	The presence of this flavonoid in monocyte cultures increased the expression of CD163 and IkappaBalpha and the release of IL-10 and transforming growth factor beta (TGF-beta) in the culture supernatants, polarising these cells from the M1-like profile to the M2-like profile.	Flavonoids	21-30	tumor necrosis factor	Homo sapiens	132-163
33045562-6	2020	The presence of this flavonoid in monocyte cultures increased the expression of CD163 and IkappaBalpha and the release of IL-10 and transforming growth factor beta (TGF-beta) in the culture supernatants, polarising these cells from the M1-like profile to the M2-like profile.	Flavonoids	21-30	transforming growth factor alpha	Homo sapiens	165-173
33135301-3	2020	Here we showed that Nepetin, a natural bioactive flavonoid with proven anti-inflammatory and anti-proliferative properties, potently inhibited RANKL-induced osteoclast differentiation, formation and bone resorption in vitro, and protected mice against the deleterious effects of titanium particle-induced calvarial osteolysis in vivo.	Flavonoids	49-58	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	143-148
32125461-7	2020	Also, the flavonoids significantly reduced the levels of respective serum oxidative and proinflammatory markers such as superoxide dismutase (SOD), myeloperoxidase (MPO), malondialdehyde (MDA), prostaglandins E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-beta), and C-reactive protein (CRP).	Flavonoids	10-20	myeloperoxidase	Rattus norvegicus	148-163
32125461-7	2020	Also, the flavonoids significantly reduced the levels of respective serum oxidative and proinflammatory markers such as superoxide dismutase (SOD), myeloperoxidase (MPO), malondialdehyde (MDA), prostaglandins E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-beta), and C-reactive protein (CRP).	Flavonoids	10-20	myeloperoxidase	Rattus norvegicus	165-168
32125461-7	2020	Also, the flavonoids significantly reduced the levels of respective serum oxidative and proinflammatory markers such as superoxide dismutase (SOD), myeloperoxidase (MPO), malondialdehyde (MDA), prostaglandins E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-beta), and C-reactive protein (CRP).	Flavonoids	10-20	tumor necrosis factor	Rattus norvegicus	220-247
32125461-7	2020	Also, the flavonoids significantly reduced the levels of respective serum oxidative and proinflammatory markers such as superoxide dismutase (SOD), myeloperoxidase (MPO), malondialdehyde (MDA), prostaglandins E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-beta), and C-reactive protein (CRP).	Flavonoids	10-20	tumor necrosis factor	Rattus norvegicus	249-258
32125461-7	2020	Also, the flavonoids significantly reduced the levels of respective serum oxidative and proinflammatory markers such as superoxide dismutase (SOD), myeloperoxidase (MPO), malondialdehyde (MDA), prostaglandins E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-beta), and C-reactive protein (CRP).	Flavonoids	10-20	C-reactive protein	Rattus norvegicus	293-311
32125461-7	2020	Also, the flavonoids significantly reduced the levels of respective serum oxidative and proinflammatory markers such as superoxide dismutase (SOD), myeloperoxidase (MPO), malondialdehyde (MDA), prostaglandins E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-beta (IL-beta), and C-reactive protein (CRP).	Flavonoids	10-20	C-reactive protein	Rattus norvegicus	313-316
33069760-0	2020	Flavonoids targeting NRF2 in neurodegenerative disorders.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
33069760-7	2020	The current review focuses on Nrf2 targeting by flavonoids in the prevention and treatment of neurodegenerative disorders, addressing the most contemporary information available on this timely subject.	Flavonoids	48-58	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
33045572-0	2020	Anti-inflammatory effects of natural flavonoid diosmetin in IL-4 and LPS-induced macrophage activation and atopic dermatitis model.	Flavonoids	37-46	interleukin 4	Mus musculus	60-64
32902794-8	2020	Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others.	Flavonoids	0-10	vascular endothelial growth factor A	Homo sapiens	116-120
33089540-6	2020	Together, rutin as a novel antihypertensive flavonoid could provide an unimaginable benefits for the management of hypertension through inhibition of angiotensin converting enzyme and mineralocorticoid receptor.	Flavonoids	44-53	angiotensin I converting enzyme	Rattus norvegicus	150-179
33089540-6	2020	Together, rutin as a novel antihypertensive flavonoid could provide an unimaginable benefits for the management of hypertension through inhibition of angiotensin converting enzyme and mineralocorticoid receptor.	Flavonoids	44-53	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	184-210
33089540-10	2020	The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin.	Flavonoids	39-48	angiotensin I converting enzyme	Rattus norvegicus	59-88
33089540-10	2020	The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin.	Flavonoids	39-48	angiotensin I converting enzyme	Rattus norvegicus	90-93
33328980-0	2020	Total Flavonoids of Rhizoma Drynariae Enhances Angiogenic-Osteogenic Coupling During Distraction Osteogenesis by Promoting Type H Vessel Formation Through PDGF-BB/PDGFR-beta Instead of HIF-1alpha/ VEGF Axis.	Flavonoids	6-16	platelet derived growth factor receptor alpha	Rattus norvegicus	163-173
33328980-0	2020	Total Flavonoids of Rhizoma Drynariae Enhances Angiogenic-Osteogenic Coupling During Distraction Osteogenesis by Promoting Type H Vessel Formation Through PDGF-BB/PDGFR-beta Instead of HIF-1alpha/ VEGF Axis.	Flavonoids	6-16	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	185-195
33328980-0	2020	Total Flavonoids of Rhizoma Drynariae Enhances Angiogenic-Osteogenic Coupling During Distraction Osteogenesis by Promoting Type H Vessel Formation Through PDGF-BB/PDGFR-beta Instead of HIF-1alpha/ VEGF Axis.	Flavonoids	6-16	vascular endothelial growth factor A	Rattus norvegicus	197-201
33261005-0	2020	The Protective Effects of Flavonoids in Cataract Formation through the Activation of Nrf2 and the Inhibition of MMP-9.	Flavonoids	26-36	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
33179911-3	2020	The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3",4"-hydroxylation inhibit recombinant human (rh)ACE2 activity.	Flavonoids	48-58	angiotensin converting enzyme 2	Homo sapiens	143-147
33261005-0	2020	The Protective Effects of Flavonoids in Cataract Formation through the Activation of Nrf2 and the Inhibition of MMP-9.	Flavonoids	26-36	matrix metallopeptidase 9	Homo sapiens	112-117
33212830-8	2020	The calculated binding free energies of the O-methylated flavonoids (1 and 4-6) and chalcones (2 and 3) to MAO-A matched closely with the trend in the experimental IC50"s.	Flavonoids	57-67	monoamine oxidase A	Homo sapiens	107-112
33222615-12	2022	Flavonoids exhibit binding efficacy against HNE.	Flavonoids	0-10	elastase, neutrophil expressed	Homo sapiens	44-47
33222615-13	2022	Flavonoids may serve as potent inhibitors for HNE.	Flavonoids	0-10	elastase, neutrophil expressed	Homo sapiens	46-49
33251983-6	2022	The present study aimed to screen several libraries of synthetic flavonoids and benzisothiazolinones as potential SARS-CoV-2 Mpro inhibitors using in silico methods.	Flavonoids	65-75	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	125-129
33251983-11	2022	Our in-silico study demonstrated that synthetic analogs of flavonoids, particularly thioflavonols, have a strong tendency to inhibit the main protease Mpro, and thereby inhibit the reproduction of SARS-CoV-2.	Flavonoids	59-69	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	151-155
33251987-0	2022	Role of cardiac drugs and flavonoids on the IRE1-JNK pathway as revealed by re-ranked molecular docking scores, MM/PBSA and umbrella sampling.	Flavonoids	26-36	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	44-48
33251987-0	2022	Role of cardiac drugs and flavonoids on the IRE1-JNK pathway as revealed by re-ranked molecular docking scores, MM/PBSA and umbrella sampling.	Flavonoids	26-36	mitogen-activated protein kinase 8	Homo sapiens	49-52
33251987-3	2022	In this study, we investigated interactions of statins, ace inhibitors, antiarrhythmic drugs and flavonoids in IRE1, ASK1(apoptosis signal-regulating kinase 1) and JNK1 at an atomic level in comparison with their well-known inhibitors.	Flavonoids	97-107	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	111-115
33251987-3	2022	In this study, we investigated interactions of statins, ace inhibitors, antiarrhythmic drugs and flavonoids in IRE1, ASK1(apoptosis signal-regulating kinase 1) and JNK1 at an atomic level in comparison with their well-known inhibitors.	Flavonoids	97-107	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	117-121
33251987-3	2022	In this study, we investigated interactions of statins, ace inhibitors, antiarrhythmic drugs and flavonoids in IRE1, ASK1(apoptosis signal-regulating kinase 1) and JNK1 at an atomic level in comparison with their well-known inhibitors.	Flavonoids	97-107	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	122-158
33251987-3	2022	In this study, we investigated interactions of statins, ace inhibitors, antiarrhythmic drugs and flavonoids in IRE1, ASK1(apoptosis signal-regulating kinase 1) and JNK1 at an atomic level in comparison with their well-known inhibitors.	Flavonoids	97-107	mitogen-activated protein kinase 8	Homo sapiens	164-168
33251987-7	2022	Norizalpinine from the flavonoid group had a strong binding interaction with IRE1, and amiodarone from the antiarrhythmic drug group had high binding affinities with IRE1, ASK1 and JNK1.	Flavonoids	23-32	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	77-81
33212830-10	2020	The natural O-methylated flavonoid (1) with highly potent inhibition (IC50 33 nM; Ki 37.9 nM) and >292 fold selectivity against human MAO-A (vs. MAO-B) provides a new drug lead for the treatment of neurological disorders.	Flavonoids	25-34	monoamine oxidase A	Homo sapiens	134-139
33212830-10	2020	The natural O-methylated flavonoid (1) with highly potent inhibition (IC50 33 nM; Ki 37.9 nM) and >292 fold selectivity against human MAO-A (vs. MAO-B) provides a new drug lead for the treatment of neurological disorders.	Flavonoids	25-34	monoamine oxidase B	Homo sapiens	145-150
32745606-9	2020	Thus, in addition to inhibition of the ZO-1-CLD interaction, activation of both transforming growth factor-beta (TGF-beta) and MEK/ERK signaling pathways have been suggested to be involved in TJ reduction by these flavonoids.	Flavonoids	214-224	protransforming growth factor alpha	Canis lupus familiaris	113-121
33167830-3	2020	This review deals with the current state of knowledge on flavonoids-SA complex over the past 10 years, mainly involved multi-spectroscopic techniques and molecular dynamics simulation studies to explore the binding mechanism, thermodynamics and structural aspects of flavonoids binding to SA.	Flavonoids	57-67	albumin	Homo sapiens	289-291
33202848-6	2020	Furthermore, all the six flavonoids could significantly inhibit the secretion of IL-1beta, IL-6, NO (p < 0.01) and the protein expression of NF-kappaB p-p65 (p < 0.01) in LPS-stimulated RAW264.7 cells.	Flavonoids	25-35	interleukin 1 alpha	Mus musculus	81-89
33202848-6	2020	Furthermore, all the six flavonoids could significantly inhibit the secretion of IL-1beta, IL-6, NO (p < 0.01) and the protein expression of NF-kappaB p-p65 (p < 0.01) in LPS-stimulated RAW264.7 cells.	Flavonoids	25-35	interleukin 6	Mus musculus	91-95
33202848-6	2020	Furthermore, all the six flavonoids could significantly inhibit the secretion of IL-1beta, IL-6, NO (p < 0.01) and the protein expression of NF-kappaB p-p65 (p < 0.01) in LPS-stimulated RAW264.7 cells.	Flavonoids	25-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	141-150
33202848-6	2020	Furthermore, all the six flavonoids could significantly inhibit the secretion of IL-1beta, IL-6, NO (p < 0.01) and the protein expression of NF-kappaB p-p65 (p < 0.01) in LPS-stimulated RAW264.7 cells.	Flavonoids	25-35	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	153-156
33164004-8	2020	Moreover, a CSI-MS method for the rapid screening of IAPP-inhibitors was established and two of the most potential inhibitors (rutin and quercitrin) were screened from a series of flavonoids.	Flavonoids	180-190	islet amyloid polypeptide	Homo sapiens	53-57
33164004-9	2020	Then, the structure-activity relationship and the mechanism between flavonoids and IAPP were studied.	Flavonoids	68-78	islet amyloid polypeptide	Homo sapiens	83-87
32926843-0	2020	The molecular mechanism involved in cardioprotection by the dietary flavonoid fisetin as an agonist of PPAR-gamma in a murine model of myocardial infarction.	Flavonoids	68-77	peroxisome proliferator activated receptor gamma	Mus musculus	103-113
32926843-1	2020	The methodology exploring the cardioprotective potential of the flavonoid Fisetin through its ability to modulate PPAR-gamma was unraveled in the present study.	Flavonoids	64-73	peroxisome proliferator activated receptor gamma	Mus musculus	114-124
33170164-0	2020	Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases.	Flavonoids	0-9	brain derived neurotrophic factor	Homo sapiens	31-43
33167824-0	2021	mTor Targeting by Different Flavonoids for Cancer Prevention.	Flavonoids	28-38	mechanistic target of rapamycin kinase	Homo sapiens	0-4
33167824-6	2021	The targeting of PI3K/Akt/mTOR by flavonoids have been well documented in the scientific literature.	Flavonoids	34-44	AKT serine/threonine kinase 1	Homo sapiens	22-25
33167824-6	2021	The targeting of PI3K/Akt/mTOR by flavonoids have been well documented in the scientific literature.	Flavonoids	34-44	mechanistic target of rapamycin kinase	Homo sapiens	26-30
33167824-7	2021	In the current communication, we have covered the anticancer potential of various flavonoids especially flavones, flavanols, and isoflavones that include apigenin, luteolin, biacalein, tangeretin, epigallocatechin-3-gallate, genistein, and diadzein especially dealing with mTOR targeting.	Flavonoids	82-92	mechanistic target of rapamycin kinase	Homo sapiens	273-277
33167830-0	2020	Interaction of flavonoids with serum albumin: A review.	Flavonoids	15-25	albumin	Homo sapiens	31-44
33167830-2	2020	After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex.	Flavonoids	18-28	albumin	Homo sapiens	52-65
33167830-2	2020	After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex.	Flavonoids	18-28	albumin	Homo sapiens	67-69
33167830-2	2020	After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex.	Flavonoids	18-28	albumin	Homo sapiens	145-147
33167830-2	2020	After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex.	Flavonoids	134-144	albumin	Homo sapiens	52-65
33167830-2	2020	After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex.	Flavonoids	134-144	albumin	Homo sapiens	67-69
33167830-2	2020	After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex.	Flavonoids	134-144	albumin	Homo sapiens	145-147
33167830-3	2020	This review deals with the current state of knowledge on flavonoids-SA complex over the past 10 years, mainly involved multi-spectroscopic techniques and molecular dynamics simulation studies to explore the binding mechanism, thermodynamics and structural aspects of flavonoids binding to SA.	Flavonoids	267-277	albumin	Homo sapiens	68-70
33167830-3	2020	This review deals with the current state of knowledge on flavonoids-SA complex over the past 10 years, mainly involved multi-spectroscopic techniques and molecular dynamics simulation studies to explore the binding mechanism, thermodynamics and structural aspects of flavonoids binding to SA.	Flavonoids	57-67	albumin	Homo sapiens	68-70
33167830-3	2020	This review deals with the current state of knowledge on flavonoids-SA complex over the past 10 years, mainly involved multi-spectroscopic techniques and molecular dynamics simulation studies to explore the binding mechanism, thermodynamics and structural aspects of flavonoids binding to SA.	Flavonoids	267-277	albumin	Homo sapiens	289-291
33167830-4	2020	Especially, the novel method, capillary electrophoresis, high performance affinity chromatography approach, native mass spectrometry and microscale thermophoresis used in characterization of the interaction between flavonoids and SA as well as flavonoid-based fluorescent probe for SA measurement are also included in this review.	Flavonoids	215-225	albumin	Homo sapiens	230-232
33167830-4	2020	Especially, the novel method, capillary electrophoresis, high performance affinity chromatography approach, native mass spectrometry and microscale thermophoresis used in characterization of the interaction between flavonoids and SA as well as flavonoid-based fluorescent probe for SA measurement are also included in this review.	Flavonoids	215-225	albumin	Homo sapiens	282-284
33167830-4	2020	Especially, the novel method, capillary electrophoresis, high performance affinity chromatography approach, native mass spectrometry and microscale thermophoresis used in characterization of the interaction between flavonoids and SA as well as flavonoid-based fluorescent probe for SA measurement are also included in this review.	Flavonoids	215-224	albumin	Homo sapiens	282-284
33171970-2	2020	Chrysin (CHR) is a natural flavonoid that is limited by its low solubility to exert its anti-inflammatory, antioxidant and anti-fibrotic properties.	Flavonoids	27-36	chromate resistance; sulfate transport	Homo sapiens	0-7
33171970-2	2020	Chrysin (CHR) is a natural flavonoid that is limited by its low solubility to exert its anti-inflammatory, antioxidant and anti-fibrotic properties.	Flavonoids	27-36	chromate resistance; sulfate transport	Homo sapiens	9-12
32942157-5	2020	In this study, the inhibitory effects of 17 plant-derived compounds and 19 colonic flavonoid metabolites on CYP2D6 were examined, employing two assays with different test substrates.	Flavonoids	83-92	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	108-114
32768503-6	2020	The results reveal that out of 23 natural flavonoids and 25 synthetic indole chalcones, 30 compounds are capable of Mpro deactivation as well as potentially lowering the efficiency of Mpro function.	Flavonoids	42-52	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	116-120
32768503-6	2020	The results reveal that out of 23 natural flavonoids and 25 synthetic indole chalcones, 30 compounds are capable of Mpro deactivation as well as potentially lowering the efficiency of Mpro function.	Flavonoids	42-52	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	184-188
33146631-4	2021	The flavonoid and saponin-rich fractions showed in vitro hepatoprotective and antioxidant activity comparable to those of flavonoid complex silymarin (60 mug/mL) in a model of metabolic bioactivation, induced by CCl4.	Flavonoids	4-13	C-C motif chemokine ligand 4	Rattus norvegicus	212-216
33073981-0	2020	Scope of beta-Secretase (BACE1)-Targeted Therapy in Alzheimer"s Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition.	Flavonoids	89-98	beta-secretase 1	Homo sapiens	25-30
33073981-0	2020	Scope of beta-Secretase (BACE1)-Targeted Therapy in Alzheimer"s Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition.	Flavonoids	89-98	beta-secretase 1	Homo sapiens	126-131
33073981-10	2020	We have particularly highlighted the scope of flavonoids as a new generation of nontoxic BACE1 inhibitory scaffolds.	Flavonoids	46-56	beta-secretase 1	Homo sapiens	89-94
33148043-2	2022	Herein, we determined the specificity of FDA approved potential anti-cancer natural flavonoid decursinol angelate (DA), thymol (TH) and a propionic acid derivative ibuprofen (IB), for the inactivation of CATB.	Flavonoids	84-93	cathepsin B	Homo sapiens	204-208
32950828-6	2020	Flavonoids could up regulate the low expression of autophagy related proteins (Beclin 1 (Bcl-2-interacting protein with a coiled-coil domain 1) and LC3 (microtubule-associated protein 1 light chain 3)) caused by AlCl3 exposure.	Flavonoids	0-10	beclin 1	Rattus norvegicus	79-87
33143000-0	2020	The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals.	Flavonoids	14-23	AKT serine/threonine kinase 1	Homo sapiens	126-129
33828360-0	2020	Molecular Docking Study of Naturally Derived Flavonoids with Antiapoptotic BCL-2 and BCL-XL Proteins toward Ovarian Cancer Treatment.	Flavonoids	45-55	BCL2 apoptosis regulator	Homo sapiens	75-80
33828360-4	2020	This study aimed to determine the binding interaction of five naturally derived flavonoids (biochanin A, myricetin, apigenin, galangin, and fisetin) with potential antiapoptotic target proteins (Bcl-2 and Bcl-xl).	Flavonoids	80-90	BCL2 apoptosis regulator	Homo sapiens	195-200
33828360-4	2020	This study aimed to determine the binding interaction of five naturally derived flavonoids (biochanin A, myricetin, apigenin, galangin, and fisetin) with potential antiapoptotic target proteins (Bcl-2 and Bcl-xl).	Flavonoids	80-90	BCL2 like 1	Homo sapiens	205-211
33828360-7	2020	Our findings showed that all the flavonoids showed better binding affinity with Bcl-xl than that of Bcl-2 proteins.	Flavonoids	33-43	BCL2 like 1	Homo sapiens	80-86
33828360-7	2020	Our findings showed that all the flavonoids showed better binding affinity with Bcl-xl than that of Bcl-2 proteins.	Flavonoids	33-43	BCL2 apoptosis regulator	Homo sapiens	100-105
33828360-9	2020	Meanwhile, the other flavonoids docked with Bcl-xl protein showed binding affinities, ranging from -8.0 to -8.6 kcal/mol.	Flavonoids	21-31	BCL2 like 1	Homo sapiens	44-50
33828360-11	2020	The present results indicate that all flavonoids could potentially serve as Bcl-xl protein inhibitors, which would consequently lead to apoptotic process in ovarian cancers.	Flavonoids	38-48	BCL2 like 1	Homo sapiens	76-82
32789659-0	2020	Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor alpha expression.	Flavonoids	8-17	estrogen receptor 1 (alpha)	Mus musculus	162-185
33128532-3	2022	In this study, flavonoids were extracted from MPL and the components in the MPL flavonoids as well as the antioxidant capacity of MPL flavonoids were analysed.	Flavonoids	15-25	MPL proto-oncogene, thrombopoietin receptor	Rattus norvegicus	46-49
33128532-5	2022	MPL flavonoids were administered daily at a dose of 50, 100, and 200 mg/kg body weight to the rats for 2 weeks prior to injection of CC14.	Flavonoids	4-14	MPL proto-oncogene, thrombopoietin receptor	Rattus norvegicus	0-3
33128532-6	2022	Treatment with MPL flavonoids, especially at a dose of 200 mg/kg, attenuated CCl4-induced increases in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, nitric oxide, malondialdehyde, tumour necrosis factor-alpha, interleukin-1beta, and interleukin-6, as well as reductions in superoxide dismutase and glutathione peroxidase.	Flavonoids	19-29	MPL proto-oncogene, thrombopoietin receptor	Rattus norvegicus	15-18
33128532-6	2022	Treatment with MPL flavonoids, especially at a dose of 200 mg/kg, attenuated CCl4-induced increases in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, nitric oxide, malondialdehyde, tumour necrosis factor-alpha, interleukin-1beta, and interleukin-6, as well as reductions in superoxide dismutase and glutathione peroxidase.	Flavonoids	19-29	C-C motif chemokine ligand 4	Rattus norvegicus	77-81
33128532-7	2022	Microarray analyses showed that co-treatment with MPL flavonoids and CCl4 up-regulated many antioxidant and anti-apoptotic genes, but down-regulated several pro-inflammatory genes, compared to treatment with CCl4 alone.	Flavonoids	54-64	MPL proto-oncogene, thrombopoietin receptor	Rattus norvegicus	50-53
33128532-7	2022	Microarray analyses showed that co-treatment with MPL flavonoids and CCl4 up-regulated many antioxidant and anti-apoptotic genes, but down-regulated several pro-inflammatory genes, compared to treatment with CCl4 alone.	Flavonoids	54-64	C-C motif chemokine ligand 4	Rattus norvegicus	208-212
33128532-8	2022	PCR and western blot assays further identified that MPL flavonoids increased GPX1, TMX1, TXN, and XIAP expression, but decreased IL-1 and IL1RAP expression and inhibited Jak/stat3 signalling.	Flavonoids	56-66	MPL proto-oncogene, thrombopoietin receptor	Rattus norvegicus	52-55
33128532-9	2022	In conclusion, MPL flavonoids exerted hepatoprotective effects via antioxidant and gene regulatory mechanisms.	Flavonoids	19-29	MPL proto-oncogene, thrombopoietin receptor	Rattus norvegicus	15-18
33143000-0	2020	The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals.	Flavonoids	14-23	hexokinase 2	Homo sapiens	140-143
33143000-0	2020	The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals.	Flavonoids	14-23	mechanistic target of rapamycin kinase	Homo sapiens	148-152
33063510-0	2020	Effects of Different Dietary Flavonoids on Dipeptidyl Peptidase-IV Activity and Expression: Insights into Structure-Activity Relationship.	Flavonoids	29-39	dipeptidyl peptidase 4	Homo sapiens	43-66
33063510-1	2020	The inhibitory effects of 30 dietary flavonoids on dipeptidyl peptidase-IV (DPP-IV) were investigated to illustrate their quantitative structure-activity relationship (QSAR) and further explore their inhibition at the cellular level.	Flavonoids	37-47	dipeptidyl peptidase 4	Homo sapiens	51-74
33063510-1	2020	The inhibitory effects of 30 dietary flavonoids on dipeptidyl peptidase-IV (DPP-IV) were investigated to illustrate their quantitative structure-activity relationship (QSAR) and further explore their inhibition at the cellular level.	Flavonoids	37-47	dipeptidyl peptidase 4	Homo sapiens	76-82
33192517-3	2020	Treatment with flavonoids (naringenin, quercetin, and naringin) plus Balsamin for 48 h reduced HepG2 and MCF-7 cell viability, increased the activation of caspase-3 and -8, and induced apoptosis through up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes.	Flavonoids	15-25	caspase 3	Homo sapiens	155-171
33063510-6	2020	Moreover, the three flavonoids mentioned above could effectively suppress DPP-IV activity and expression in Caco-2 cells.	Flavonoids	20-30	dipeptidyl peptidase 4	Homo sapiens	74-80
33063510-7	2020	This work may supply new insights into dietary flavonoids as DPP-IV inhibitors for controlling blood glucose.	Flavonoids	47-57	dipeptidyl peptidase 4	Homo sapiens	61-67
33111622-3	2022	The aim of this study was to investigate the interactions of twenty-three phytochemicals belonging to different flavonoid subgroups with the receptor binding domain (RBD) of the spike glycoprotein of 2019-nCoV, and cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B and L (CatB/L)].	Flavonoids	112-121	transmembrane serine protease 2	Homo sapiens	235-266
33111622-3	2022	The aim of this study was to investigate the interactions of twenty-three phytochemicals belonging to different flavonoid subgroups with the receptor binding domain (RBD) of the spike glycoprotein of 2019-nCoV, and cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B and L (CatB/L)].	Flavonoids	112-121	transmembrane serine protease 2	Homo sapiens	268-275
33111622-3	2022	The aim of this study was to investigate the interactions of twenty-three phytochemicals belonging to different flavonoid subgroups with the receptor binding domain (RBD) of the spike glycoprotein of 2019-nCoV, and cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B and L (CatB/L)].	Flavonoids	112-121	cathepsin B	Homo sapiens	278-295
33111622-3	2022	The aim of this study was to investigate the interactions of twenty-three phytochemicals belonging to different flavonoid subgroups with the receptor binding domain (RBD) of the spike glycoprotein of 2019-nCoV, and cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B and L (CatB/L)].	Flavonoids	112-121	cathepsin B	Homo sapiens	297-301
33026809-5	2020	Three flavonoids, apigenin, hispidulin, and luteolin, showed MNK2 inhibitory activity with IC50 values of 308, 252, and 579 nM, respectively.	Flavonoids	6-16	MAPK interacting serine/threonine kinase 2	Homo sapiens	61-65
33126490-0	2020	Associations between Intake of Dietary Flavonoids and 10-Year Incidence of Age-Related Hearing Loss.	Flavonoids	39-49	renin binding protein	Homo sapiens	75-78
33126490-2	2020	We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss.	Flavonoids	86-95	renin binding protein	Homo sapiens	132-135
33312547-8	2020	These results suggest that flavonoids could function as mitochondrial uncouplers to mitigate neurodegeneration in aged C. elegans, possibly via a PINK1/Parkin mitophagy process.	Flavonoids	27-37	Serine/threonine-protein kinase pink-1, mitochondrial	Caenorhabditis elegans	146-151
33120983-4	2020	The effect of flavonoids on the protein expression level of claudin (CLD)-2 and its subcellular localization were investigated.	Flavonoids	14-24	claudin 2	Canis lupus familiaris	60-75
33077836-5	2020	In this paper five phytochemicals, which belong to flavonoid and anthraquinone subclass, have been selected as small molecules in molecular docking study of spike protein of SARS-CoV2 with its human receptor ACE2 molecule.	Flavonoids	51-60	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	157-162
33077836-5	2020	In this paper five phytochemicals, which belong to flavonoid and anthraquinone subclass, have been selected as small molecules in molecular docking study of spike protein of SARS-CoV2 with its human receptor ACE2 molecule.	Flavonoids	51-60	angiotensin converting enzyme 2	Homo sapiens	208-212
33050575-0	2020	Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?	Flavonoids	42-52	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
33086545-4	2020	The contents of carotenoid, soluble protein, soluble sugar, vitamin C, total flavonoids, total polyphenol and contents of total glucosinolates and organic Se were dramatically improved through the combination of Se and LED light quality.	Flavonoids	77-87	small integral membrane protein 10 like 2A	Homo sapiens	219-222
32464460-1	2020	In this study, the inhibitory potentials of food originated 34 phenolic acids, and flavonoid compounds were screened against acetylcholinesterase, butyrylcholinesterase, urease, and tyrosinase enzymes.	Flavonoids	83-92	tyrosinase	Homo sapiens	182-192
33053908-6	2020	We screened 39 flavonoids containing 26 flavones and 13 flavanones using the EGR1 promoter reporter activity assay and observed that chrysoeriol exerted the highest inhibitory activity on tumor necrosis factor alpha (TNFalpha)-induced EGR-1 expression.	Flavonoids	15-25	tumor necrosis factor	Homo sapiens	188-215
33053908-6	2020	We screened 39 flavonoids containing 26 flavones and 13 flavanones using the EGR1 promoter reporter activity assay and observed that chrysoeriol exerted the highest inhibitory activity on tumor necrosis factor alpha (TNFalpha)-induced EGR-1 expression.	Flavonoids	15-25	tumor necrosis factor	Homo sapiens	217-225
33054569-10	2022	These findings broaden our understanding of Vincetoxicum metabolites and highlight the potential of glycosylated flavonoids as AChE inhibitors.	Flavonoids	113-123	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
32750437-0	2020	Flavonoids-mediated SIRT1 signaling activation in hepatic disorders.	Flavonoids	0-10	sirtuin 1	Homo sapiens	20-25
32750437-7	2020	Additionally, molecular modeling simulations were applied to explore the potential binding mode of these flavonoids to SIRT1.	Flavonoids	105-115	sirtuin 1	Homo sapiens	119-124
32750437-8	2020	The complied information and molecular docking simulations suggested that SIRT1 signaling is involved in the beneficial pharmacologic activities of flavonoids in different hepatic diseases.	Flavonoids	148-158	sirtuin 1	Homo sapiens	74-79
33050575-2	2020	The role of dietary flavonoids in activating Nrf2/ARE in relation to cancer chemoprevention or cancer promotion is not well established.	Flavonoids	20-30	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
33050575-3	2020	Here we summarize the dual effects of flavonoids in cancer chemoprevention and cancer promotion with respect to the regulation of the Nrf2/ARE pathway, while underlying the possible cellular mechanisms.	Flavonoids	38-48	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
33050575-8	2020	Paradoxically, some flavonoids, including luteolin, apigenin, and chrysin, inhibit the Nrf2/ARE pathway in vitro.	Flavonoids	20-30	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
33039058-4	2020	The antioxidant potential of DpL was evaluated by estimating the total flavonoid and total phenolic content (TFC and TPC, respectively).	Flavonoids	71-80	prion like protein doppel	Homo sapiens	29-32
32480277-0	2020	Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.	Flavonoids	25-35	albumin	Homo sapiens	46-59
32480277-1	2020	The molecular structure properties-binding affinity relationship of a series of flavonoids and bovine serum albumin (BSA) was investigated in vitro from comparing the binding constants determined through the fluorescence method.	Flavonoids	80-90	albumin	Homo sapiens	102-115
32480277-3	2020	The hydroxylation at the positions C3, C6, C4", C5" (for type I) and C5, C3" (for type II) were in favor of forming hydrogen bonds with the amino acids of BSA, which was of great importance in the binding and interaction between flavonoids and the protein.	Flavonoids	229-239	complement C5	Homo sapiens	48-75
32474018-0	2020	Repeated psychosocial stress causes glutamic acid decarboxylase isoform-67, oxidative-Nox-2 changes and neuroinflammation in mice: prevention by treatment with a neuroactive flavonoid, morin.	Flavonoids	174-183	cytochrome b-245, beta polypeptide	Mus musculus	86-91
32438224-0	2020	Antioxidant and pancreatic lipase inhibitory effects of flavonoids from different citrus peel extracts: An in vitro study.	Flavonoids	56-66	pancreatic lipase	Homo sapiens	16-33
32816867-7	2020	P-gp modulatory effects have been previously demonstrated using selected TCM, including the flavonoids, alkaloids, terpenoids, coumarins, and quinonoids compounds, and some Chinese medicine extracts.	Flavonoids	92-102	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
32816867-11	2020	Significance Statement This review summarized some traditional Chinese medicine identified to have a modulatory effect towards P-gp, including flavonoids, alkaloids, terpenoids, coumarins, quinonoids compounds and some Chinese medicine extracts, and introduced the possible mechanisms.	Flavonoids	143-153	ATP binding cassette subfamily B member 1	Homo sapiens	127-131
32619025-4	2020	The results revealed that honey obtained from Shabshir Hessa, El Gharbia Governorate (GSH-1), showed the best quality with the highest monosaccharide and phenolic and flavonoid content (73.07%, 363.07, and 15.33 mg/g, respectively) and clear of biotic and abiotic contaminants, reflecting good hygienic, environmental conditions and apiarian practices.	Flavonoids	167-176	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	86-91
33005856-6	2020	MYB58 and MYB63 overexpression lines had characteristic soluble phenolic profiles with large amounts of monolignol glucosides and sinapoyl esters, but decreased flavonoids.	Flavonoids	161-171	myb domain protein 58	Arabidopsis thaliana	0-5
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Flavonoids	24-34	amyloid beta precursor protein	Homo sapiens	55-65
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Flavonoids	24-34	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Flavonoids	24-34	kelch like ECH associated protein 1	Homo sapiens	169-175
33027419-0	2020	Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp).	Flavonoids	0-9	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	115-119
33027419-0	2020	Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp).	Flavonoids	0-9	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	155-159
32462548-2	2020	The present study investigated the effects of two flavonoids (apigenin and luteolin) on the production of IL-31 and IL-33 in lipopolysaccharide (LPS)-activated astrocytes.	Flavonoids	50-60	interleukin 31	Homo sapiens	106-111
32940351-0	2020	Antioxidant and hepatoprotective effects against acute CCl4 -induced liver damage in mice from red-fleshed apple flesh flavonoid extract.	Flavonoids	119-128	chemokine (C-C motif) ligand 4	Mus musculus	55-59
32473529-12	2020	A concomitant decrease in reactive oxygen species production, proinflammatory cytokines, and Glut-associated genes and proteins were identified with flavonoid treatment.	Flavonoids	149-158	solute carrier family 2 member 1	Homo sapiens	93-97
32945668-5	2020	C8-prenylated flavonoids with C2-C3 unsaturation resulted in increased ERbeta potency and selectivity [e.g., 8-prenylapigenin (8-PA), EC50 (ERbeta): 0.0035 +- 0.00040 muM], whereas 4"-methoxy or C3 hydroxy groups reduced activity [e.g., icaritin, EC50 (ERbeta): 1.7 +- 0.70 muM].	Flavonoids	14-24	estrogen receptor 1	Homo sapiens	71-77
32945668-5	2020	C8-prenylated flavonoids with C2-C3 unsaturation resulted in increased ERbeta potency and selectivity [e.g., 8-prenylapigenin (8-PA), EC50 (ERbeta): 0.0035 +- 0.00040 muM], whereas 4"-methoxy or C3 hydroxy groups reduced activity [e.g., icaritin, EC50 (ERbeta): 1.7 +- 0.70 muM].	Flavonoids	14-24	estrogen receptor 1	Homo sapiens	140-146
32945668-5	2020	C8-prenylated flavonoids with C2-C3 unsaturation resulted in increased ERbeta potency and selectivity [e.g., 8-prenylapigenin (8-PA), EC50 (ERbeta): 0.0035 +- 0.00040 muM], whereas 4"-methoxy or C3 hydroxy groups reduced activity [e.g., icaritin, EC50 (ERbeta): 1.7 +- 0.70 muM].	Flavonoids	14-24	estrogen receptor 1	Homo sapiens	140-146
32945668-8	2020	Botanicals with ERbeta-preferential flavonoids could plausibly contribute to ERbeta-protective benefits in menopausal women.	Flavonoids	36-46	estrogen receptor 1	Homo sapiens	16-22
32945668-8	2020	Botanicals with ERbeta-preferential flavonoids could plausibly contribute to ERbeta-protective benefits in menopausal women.	Flavonoids	36-46	estrogen receptor 1	Homo sapiens	77-83
32999301-5	2020	Additionally, the transcriptional analysis of thirteen genes controlling the phenylpropanoid, chlorogenic acid and flavonoid biosynthetic pathways revealed that most of the studied genes were induced after POT1 treatments.	Flavonoids	115-124	protection of telomeres 1	Homo sapiens	206-210
32999301-6	2020	The stronger expression level of F3H, the key enzyme in flavonoid biosynthesis in plants, (588.133-fold) and AN2, anthocyanin 2 transcription factor, (97.005-fold) suggested that the accumulation flavonoid, especially anthocyanin, might play significant roles in plant defense against viral infection.	Flavonoids	196-205	AN2	Solanum tuberosum	109-112
32993050-9	2020	MOS1 was found to regulate the expression of flavonoid and anthocyanin biosynthetic genes in response to exogenous sucrose and high-light stress but with different underlying mechanisms, showing multiple functions in addition to immunity regulation in plant development.	Flavonoids	45-54	ARM repeat superfamily protein	Arabidopsis thaliana	0-4
32993092-0	2020	Lupeol, a Plant-Derived Flavonoid, Protects Mice Brains against Abeta-Induced Oxidative Stress and Neurodegeneration.	Flavonoids	24-33	amyloid beta (A4) precursor protein	Mus musculus	64-69
32993165-5	2020	Based on differentially expressed gene analysis, we found that ectopic expression of PAP1 induced the expression of genes involved in the "phenylpropanoid biosynthesis" (24 genes), and "flavonoid biosynthesis" (17 genes) pathways, resulting in 191- to 341-fold increases in anthocyanin production compared to transgenic control (TC) hairy roots.	Flavonoids	186-195	PDGFA associated protein 1	Mus musculus	85-89
33005856-6	2020	MYB58 and MYB63 overexpression lines had characteristic soluble phenolic profiles with large amounts of monolignol glucosides and sinapoyl esters, but decreased flavonoids.	Flavonoids	161-171	myb domain protein 63	Arabidopsis thaliana	10-15
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Flavonoids	135-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
32812559-0	2020	A DS2-specific flavonoid-based probe with a unique dual-emissive response to human serum albumin.	Flavonoids	15-24	albumin	Homo sapiens	83-96
32812559-1	2020	The hydroxyl substituent in flavonoids can cause the binding site to change from DS1 to DS2 and restore the ESIPT process of flavonoids, thereby leading to a unique dual-emissive response towards human serum albumin.	Flavonoids	28-38	albumin	Homo sapiens	202-215
32812559-1	2020	The hydroxyl substituent in flavonoids can cause the binding site to change from DS1 to DS2 and restore the ESIPT process of flavonoids, thereby leading to a unique dual-emissive response towards human serum albumin.	Flavonoids	125-135	albumin	Homo sapiens	202-215
33015460-3	2020	Natural flavonoids, in this case xanthohumol (XN), have been reported to attenuate TCDD toxicity through inhibition of the transformation of the AhR.	Flavonoids	8-18	aryl hydrocarbon receptor	Homo sapiens	145-148
32973912-2	2020	This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes.	Flavonoids	82-92	adiponectin, C1Q and collagen domain containing	Homo sapiens	103-114
32437808-2	2020	In this study, we describe the binding and enzyme kinetics of AR by naringenin, a bioflavonoid present in many dietary sources.	Flavonoids	82-94	aldo-keto reductase family 1 member B	Homo sapiens	62-64
32446949-0	2020	Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats.	Flavonoids	10-20	leucine rich repeat and Ig domain containing 1	Rattus norvegicus	140-147
32446949-0	2020	Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats.	Flavonoids	10-20	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	148-151
32446949-0	2020	Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats.	Flavonoids	10-20	brain-derived neurotrophic factor	Rattus norvegicus	184-188
32446949-0	2020	Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats.	Flavonoids	10-20	neuregulin 1	Rattus norvegicus	189-193
32911700-8	2020	These data suggest that the activation of rPON1 and rCAT activities by M. oleifera extracts may be mediated via the effect of the specific flavonoids on the enzyme structure.	Flavonoids	139-149	paraoxonase 1	Rattus norvegicus	42-47
32828279-3	2020	An endo-beta-N-acetylglucosaminidase mutant Endo-CC N180H, which is developed as an excellent chemoenzymatic tool for creating sialylglycoproteins, was employed for the glycosylation of flavonoids.	Flavonoids	186-196	mannosidase endo-alpha	Homo sapiens	3-7
32828279-3	2020	An endo-beta-N-acetylglucosaminidase mutant Endo-CC N180H, which is developed as an excellent chemoenzymatic tool for creating sialylglycoproteins, was employed for the glycosylation of flavonoids.	Flavonoids	186-196	mannosidase endo-alpha	Homo sapiens	44-48
32828279-6	2020	Flavonoid glucosides harboring a 1,3-diol structure in the glucose moieties acted as substrates of Endo-CC N180H.	Flavonoids	0-9	mannosidase endo-alpha	Homo sapiens	99-103
32828279-7	2020	We proposed that the sialyl biantennary glycan transfer to the flavonoid by Endo-CC N180H could pave the way for the improvement of the inherent biological functions of the flavonoids and creation of novel flavonoid glycoside derivatives for future human health benefits including foods and drugs.	Flavonoids	63-72	mannosidase endo-alpha	Homo sapiens	76-80
32828279-7	2020	We proposed that the sialyl biantennary glycan transfer to the flavonoid by Endo-CC N180H could pave the way for the improvement of the inherent biological functions of the flavonoids and creation of novel flavonoid glycoside derivatives for future human health benefits including foods and drugs.	Flavonoids	173-183	mannosidase endo-alpha	Homo sapiens	76-80
32828279-7	2020	We proposed that the sialyl biantennary glycan transfer to the flavonoid by Endo-CC N180H could pave the way for the improvement of the inherent biological functions of the flavonoids and creation of novel flavonoid glycoside derivatives for future human health benefits including foods and drugs.	Flavonoids	173-182	mannosidase endo-alpha	Homo sapiens	76-80
32911700-8	2020	These data suggest that the activation of rPON1 and rCAT activities by M. oleifera extracts may be mediated via the effect of the specific flavonoids on the enzyme structure.	Flavonoids	139-149	catalase	Rattus norvegicus	52-56
32911700-9	2020	In addition, through molecular blind docking analysis, rPON1 was found to have two binding sites for flavonoids.	Flavonoids	101-111	paraoxonase 1	Rattus norvegicus	55-60
32911700-10	2020	In contrast, flavonoids bound at four sites in rCAT.	Flavonoids	13-23	catalase	Rattus norvegicus	47-51
32882984-7	2020	Caffeoylquinic acids, flavonoids and proanthocyanidins have been reported in various Sorbus spp.	Flavonoids	22-32	histocompatibility minor 13	Homo sapiens	92-95
32906729-11	2020	The flavonoids fisetin and quercetin were active in restoring ERK phosphorylation, as well as sensitivity to platinum compounds.	Flavonoids	4-14	mitogen-activated protein kinase 1	Homo sapiens	62-65
32906729-13	2020	This suggests that ERK activity is involved in mediating the function of flavonoids in restoring platinum sensitivity to OC co-cultured with cellular components of the TME.	Flavonoids	73-83	mitogen-activated protein kinase 1	Homo sapiens	19-22
32899576-2	2020	Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition.	Flavonoids	13-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
32899576-2	2020	Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition.	Flavonoids	13-22	beta-secretase 1	Homo sapiens	86-92
32768933-0	2020	Ziziphora clinopodioides flavonoids based on network pharmacology attenuates atherosclerosis in rats induced by high-fat emulsion combined with vitamin D3 by down-regulating VEGF/AKT/NF-kappaB signaling pathway.	Flavonoids	25-35	vascular endothelial growth factor A	Rattus norvegicus	174-178
32563778-0	2020	A semi-synthetic flavonoid from Bauhinia pulchella stem attenuates inflammatory osteolysis in periodontitis in rats: Impact on cytokine levels, oxidative stress, and RANK/RANKL/OPG pathway.	Flavonoids	17-26	TNF superfamily member 11	Rattus norvegicus	171-176
32563778-0	2020	A semi-synthetic flavonoid from Bauhinia pulchella stem attenuates inflammatory osteolysis in periodontitis in rats: Impact on cytokine levels, oxidative stress, and RANK/RANKL/OPG pathway.	Flavonoids	17-26	TNF receptor superfamily member 11B	Rattus norvegicus	177-180
32768933-0	2020	Ziziphora clinopodioides flavonoids based on network pharmacology attenuates atherosclerosis in rats induced by high-fat emulsion combined with vitamin D3 by down-regulating VEGF/AKT/NF-kappaB signaling pathway.	Flavonoids	25-35	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
32592805-0	2020	Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model.	Flavonoids	10-20	neuregulin 1	Rattus norvegicus	78-82
32592805-0	2020	Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model.	Flavonoids	10-20	erb-b2 receptor tyrosine kinase 4	Rattus norvegicus	83-88
32592805-0	2020	Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model.	Flavonoids	10-20	brain-derived neurotrophic factor	Rattus norvegicus	93-97
32592805-0	2020	Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model.	Flavonoids	10-20	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	98-101
33164374-12	2020	The overexpression of FBXL19-AS1 reversed the inhibitory effect of flavonoids of Sophorae Fructus on the proliferation, migration and invasion of Huh7 cells.	Flavonoids	67-77	F-box and leucine rich repeat protein 19	Homo sapiens	22-28
33084600-1	2020	7,8-Dihydroxyflavone (7,8-DHF) is a natural flavonoid compound that act as Trk-B agonist.	Flavonoids	44-53	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	75-80
32830146-1	2020	This study has investigated the effect of a potent bioflavonoid, troxerutin, on diabetes-induced changes in pro-inflammatory mediators and expression of microRNA-146a and nuclear factor-kappa-B (NF-kappaB) signaling pathway in aortic tissue of type-I diabetic rats.	Flavonoids	51-63	microRNA 146a	Rattus norvegicus	153-166
33164374-0	2020	[Mechanism of flavonoids of Sophorae Fructus in inhibiting proliferation, migration and invasion of hepatocellular carcinoma cells by regulating LncRNA FBXL19-AS1/miR-342-3p pathway].	Flavonoids	14-24	F-box and leucine rich repeat protein 19	Homo sapiens	152-158
33089226-6	2020	The supplementation of flavonoid significantly increased (p < 0.05) average daily gain (ADG) during day 0-21, tended to increase dry matter and nitrogen digestibility, significantly reduced IL-6, increased Ig-G and WBC concentrations and increased lymphocytes percentage regardless of LPS challenge.	Flavonoids	23-32	ADG	Sus scrofa	88-91
33089226-6	2020	The supplementation of flavonoid significantly increased (p < 0.05) average daily gain (ADG) during day 0-21, tended to increase dry matter and nitrogen digestibility, significantly reduced IL-6, increased Ig-G and WBC concentrations and increased lymphocytes percentage regardless of LPS challenge.	Flavonoids	23-32	interleukin-6	Sus scrofa	190-194
33164374-0	2020	[Mechanism of flavonoids of Sophorae Fructus in inhibiting proliferation, migration and invasion of hepatocellular carcinoma cells by regulating LncRNA FBXL19-AS1/miR-342-3p pathway].	Flavonoids	14-24	prostaglandin D2 receptor	Homo sapiens	159-162
33164374-12	2020	The overexpression of FBXL19-AS1 reversed the inhibitory effect of flavonoids of Sophorae Fructus on the proliferation, migration and invasion of Huh7 cells.	Flavonoids	67-77	prostaglandin D2 receptor	Homo sapiens	29-32
33164374-4	2020	qRT-PCR was used to detect the effect of flavonoids of Sophorae Fructus on the expression levels of FBXL19-AS1 and miR-342-3 p in Huh7 cells.	Flavonoids	41-51	F-box and leucine rich repeat protein 19	Homo sapiens	100-106
33164374-4	2020	qRT-PCR was used to detect the effect of flavonoids of Sophorae Fructus on the expression levels of FBXL19-AS1 and miR-342-3 p in Huh7 cells.	Flavonoids	41-51	prostaglandin D2 receptor	Homo sapiens	107-110
33164374-13	2020	Flavonoids of Sophorae Fructus could inhibite the proliferation, migration and invasion of hepatoma cells by regulating LncRNA FBXL19-AS1/miR-342-3 p pathway.	Flavonoids	0-10	F-box and leucine rich repeat protein 19	Homo sapiens	127-133
33164374-8	2020	Flavonoids of Sophorae Fructus significantly inhibited the proliferation, migration and invasion of Huh7 cells(P<0.05), promoted the expression of p21 protein(P<0.05), and inhibited the expressions of cyclinD1, MMP-2 and MMP-9(P<0.05) in a dose-dependent manner, and could reduce the activity of MMP-2 and MMP-9(P<0.05).	Flavonoids	0-10	H3 histone pseudogene 16	Homo sapiens	147-150
33164374-13	2020	Flavonoids of Sophorae Fructus could inhibite the proliferation, migration and invasion of hepatoma cells by regulating LncRNA FBXL19-AS1/miR-342-3 p pathway.	Flavonoids	0-10	prostaglandin D2 receptor	Homo sapiens	134-137
33164374-8	2020	Flavonoids of Sophorae Fructus significantly inhibited the proliferation, migration and invasion of Huh7 cells(P<0.05), promoted the expression of p21 protein(P<0.05), and inhibited the expressions of cyclinD1, MMP-2 and MMP-9(P<0.05) in a dose-dependent manner, and could reduce the activity of MMP-2 and MMP-9(P<0.05).	Flavonoids	0-10	cyclin D1	Homo sapiens	201-209
33164374-13	2020	Flavonoids of Sophorae Fructus could inhibite the proliferation, migration and invasion of hepatoma cells by regulating LncRNA FBXL19-AS1/miR-342-3 p pathway.	Flavonoids	0-10	microRNA 342	Homo sapiens	138-145
33164374-8	2020	Flavonoids of Sophorae Fructus significantly inhibited the proliferation, migration and invasion of Huh7 cells(P<0.05), promoted the expression of p21 protein(P<0.05), and inhibited the expressions of cyclinD1, MMP-2 and MMP-9(P<0.05) in a dose-dependent manner, and could reduce the activity of MMP-2 and MMP-9(P<0.05).	Flavonoids	0-10	matrix metallopeptidase 2	Homo sapiens	211-216
32863858-5	2020	Main body: Emerging evidence suggests that flavonoids, especially hesperidin (HD), naringenin (NIN), nobiletin (NOB), naringin (NRG), tangeretin (TN), hesperetin (HT) and eriodictyol (ED) are major representative bioactive ingredients that alleviate diseases through multi-targeting mechanisms, including anti-oxidative stress, anti-cytotoxicity, anti-inflammation, anti-fibrosis and anti-tumor mechanisms.	Flavonoids	43-53	C-type lectin domain family 3 member B	Homo sapiens	134-144
33164374-8	2020	Flavonoids of Sophorae Fructus significantly inhibited the proliferation, migration and invasion of Huh7 cells(P<0.05), promoted the expression of p21 protein(P<0.05), and inhibited the expressions of cyclinD1, MMP-2 and MMP-9(P<0.05) in a dose-dependent manner, and could reduce the activity of MMP-2 and MMP-9(P<0.05).	Flavonoids	0-10	matrix metallopeptidase 9	Homo sapiens	221-226
33164374-8	2020	Flavonoids of Sophorae Fructus significantly inhibited the proliferation, migration and invasion of Huh7 cells(P<0.05), promoted the expression of p21 protein(P<0.05), and inhibited the expressions of cyclinD1, MMP-2 and MMP-9(P<0.05) in a dose-dependent manner, and could reduce the activity of MMP-2 and MMP-9(P<0.05).	Flavonoids	0-10	matrix metallopeptidase 2	Homo sapiens	296-301
33164374-8	2020	Flavonoids of Sophorae Fructus significantly inhibited the proliferation, migration and invasion of Huh7 cells(P<0.05), promoted the expression of p21 protein(P<0.05), and inhibited the expressions of cyclinD1, MMP-2 and MMP-9(P<0.05) in a dose-dependent manner, and could reduce the activity of MMP-2 and MMP-9(P<0.05).	Flavonoids	0-10	matrix metallopeptidase 9	Homo sapiens	306-311
33164374-9	2020	The expression level of FBXL19-AS1 was significantly decreased in Huh7 cells treated with flavonoids of Sophorae Fructus(P<0.05), whereas the expression level of miR-342-3 p was significantly increased(P<0.05).	Flavonoids	90-100	F-box and leucine rich repeat protein 19	Homo sapiens	24-30
33164374-9	2020	The expression level of FBXL19-AS1 was significantly decreased in Huh7 cells treated with flavonoids of Sophorae Fructus(P<0.05), whereas the expression level of miR-342-3 p was significantly increased(P<0.05).	Flavonoids	90-100	prostaglandin D2 receptor	Homo sapiens	31-34
32908556-0	2020	Effect of Total Flavonoids of Oxytropis falcata Bunge on the Expression of p-JAK1-and p-STAT1-Related Proteins in Idiopathic Pulmonary Fibrosis.	Flavonoids	16-26	Janus kinase 1	Rattus norvegicus	77-81
32908556-0	2020	Effect of Total Flavonoids of Oxytropis falcata Bunge on the Expression of p-JAK1-and p-STAT1-Related Proteins in Idiopathic Pulmonary Fibrosis.	Flavonoids	16-26	signal transducer and activator of transcription 1	Rattus norvegicus	88-93
32908556-1	2020	Objective: The study aimed to explore the effect of total flavonoids of Oxytropis falcata Bunge (FOFB) on the expression of p-JAK1/p-STAT1 and SOCS3 proteins in idiopathic pulmonary fibrosis (IPF).	Flavonoids	58-68	Janus kinase 1	Rattus norvegicus	126-130
32908556-1	2020	Objective: The study aimed to explore the effect of total flavonoids of Oxytropis falcata Bunge (FOFB) on the expression of p-JAK1/p-STAT1 and SOCS3 proteins in idiopathic pulmonary fibrosis (IPF).	Flavonoids	58-68	signal transducer and activator of transcription 1	Rattus norvegicus	133-138
32908556-1	2020	Objective: The study aimed to explore the effect of total flavonoids of Oxytropis falcata Bunge (FOFB) on the expression of p-JAK1/p-STAT1 and SOCS3 proteins in idiopathic pulmonary fibrosis (IPF).	Flavonoids	58-68	suppressor of cytokine signaling 3	Rattus norvegicus	143-148
32867308-2	2020	Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition.	Flavonoids	18-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
32867308-2	2020	Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition.	Flavonoids	18-27	beta-secretase 1	Homo sapiens	87-93
32862153-0	2020	Flavonoids from Rosa roxburghii Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation in vivo.	Flavonoids	0-10	poly (ADP-ribose) polymerase family, member 1	Mus musculus	137-143
32863858-5	2020	Main body: Emerging evidence suggests that flavonoids, especially hesperidin (HD), naringenin (NIN), nobiletin (NOB), naringin (NRG), tangeretin (TN), hesperetin (HT) and eriodictyol (ED) are major representative bioactive ingredients that alleviate diseases through multi-targeting mechanisms, including anti-oxidative stress, anti-cytotoxicity, anti-inflammation, anti-fibrosis and anti-tumor mechanisms.	Flavonoids	43-53	C-type lectin domain family 3 member B	Homo sapiens	146-148
32819226-4	2021	OBJECTIVE: In this aspect, our objective was to screen essential flavonoids against possible protein targets such as SARS-CoV-2 spike glycoprotein receptor binding domain (RBD-S) and host Angiotensin Converting Enzyme-2 protease domain (PD-ACE-2) using in silico molecular docking studies.	Flavonoids	65-75	angiotensin converting enzyme 2	Homo sapiens	188-219
32923824-0	2020	Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin.	Flavonoids	72-81	C-C motif chemokine ligand 2	Homo sapiens	52-56
32819226-4	2021	OBJECTIVE: In this aspect, our objective was to screen essential flavonoids against possible protein targets such as SARS-CoV-2 spike glycoprotein receptor binding domain (RBD-S) and host Angiotensin Converting Enzyme-2 protease domain (PD-ACE-2) using in silico molecular docking studies.	Flavonoids	65-75	angiotensin converting enzyme 2	Homo sapiens	240-245
32819226-6	2021	The flavonoids that passed Lipinski rule were subjected to in silico analysis through molecular docking on RBD-S and PD-ACE-2 using Molegro Virtual Docker v6.0.	Flavonoids	4-14	angiotensin converting enzyme 2	Homo sapiens	120-125
32819226-10	2021	CONCLUSION: The current outcomes created a new paradigm in understanding biochanin A and silymarin bioflavonoids as potent inhibitors of RBD-Sand PD-ACE-2 targets respectively, further work can be extended to confirm their therapeutic potential in COVID-19.	Flavonoids	99-112	angiotensin converting enzyme 2	Homo sapiens	149-154
32422185-2	2020	The natural flavonoid Quercetin (Que) has been reported to be able to inhibit P-gp-mediated MDR in various cancer cells.	Flavonoids	12-21	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
32173137-0	2020	Corrigendum to "Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations" [Int.	Flavonoids	16-26	carboxylesterase 2	Homo sapiens	36-54
32952498-0	2020	The flavonoid-rich ethanolic extract from the green cocoon shell of silkworm has excellent antioxidation, glucosidase inhibition, and cell protective effects in vitro.	Flavonoids	4-13	glucosidase	Bombyx mori	106-117
32526242-4	2020	Here we show that the flavonoid luteolin exerts a significant cytotoxic effect on the colon cancer cell line HCT116 and the breast adenocarcinoma cell line MDA-MB231, by inducing both apoptotic and necrotic cell death, and that this effect is not impaired by HIF-1 activation.	Flavonoids	22-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	259-264
32952498-10	2020	These results clearly indicated that the flavonoid-rich EE with excellent antioxidant and glucosidase inhibition abilities significantly reduced the damage to cells caused by oxidative stress and inflammatory reactions.	Flavonoids	41-50	glucosidase	Bombyx mori	90-101
32823757-0	2020	Dietary Flavonoids in p53-Mediated Immune Dysfunctions Linking to Cancer Prevention.	Flavonoids	8-18	tumor protein p53	Homo sapiens	22-25
32823927-0	2020	Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies.	Flavonoids	9-18	vascular endothelial growth factor A	Mus musculus	95-99
32824087-0	2020	Soy Isoflavone Genistein Inhibits an Axillary Osmidrosis Risk Factor ABCC11: In Vitro Screening and Fractional Approach for ABCC11-Inhibitory Activities in Plant Extracts and Dietary Flavonoids.	Flavonoids	183-193	ATP binding cassette subfamily C member 11	Homo sapiens	69-75
32824087-8	2020	Furthermore, we examined the effects of other dietary flavonoids on the ABCC11-mediated DHEA-S transport to uncover the effects of these phytochemicals on ABCC11 function.	Flavonoids	54-64	ATP binding cassette subfamily C member 11	Homo sapiens	72-78
32823757-8	2020	Recent studies have shown the ability of flavonoids to suppress chronic inflammation, specifically by modulating p53 responses.	Flavonoids	41-51	tumor protein p53	Homo sapiens	113-116
32650643-0	2020	A novel protein tyrosine phosphatase 1 B inhibitor-geranylated flavonoid from mulberry leaves ameliorates insulin resistance.	Flavonoids	63-72	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	8-40
32785161-0	2020	Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches.	Flavonoids	23-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-70
32785161-5	2020	A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models.	Flavonoids	82-91	acetylcholinesterase (Cartwright blood group)	Homo sapiens	196-200
32785161-5	2020	A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models.	Flavonoids	82-91	beta-secretase 1	Homo sapiens	205-211
32785161-6	2020	A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed.	Flavonoids	47-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-111
32785161-6	2020	A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed.	Flavonoids	47-57	beta-secretase 1	Homo sapiens	116-122
32785161-6	2020	A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed.	Flavonoids	47-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-151
32650643-0	2020	A novel protein tyrosine phosphatase 1 B inhibitor-geranylated flavonoid from mulberry leaves ameliorates insulin resistance.	Flavonoids	63-72	insulin	Homo sapiens	106-113
32650643-10	2020	In conclusion, geranylated flavonoids in mulberry leaves inhibite PTP1B and increase the glucose consumption in insulin-resistant cells.	Flavonoids	27-37	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	66-71
32650643-10	2020	In conclusion, geranylated flavonoids in mulberry leaves inhibite PTP1B and increase the glucose consumption in insulin-resistant cells.	Flavonoids	27-37	insulin	Homo sapiens	112-119
32754990-0	2020	Nitrogen-containing flavonoid and their analogs with diverse B-ring in acetylcholinesterase and butyrylcholinesterase inhibition.	Flavonoids	20-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-91
32754990-0	2020	Nitrogen-containing flavonoid and their analogs with diverse B-ring in acetylcholinesterase and butyrylcholinesterase inhibition.	Flavonoids	20-29	butyrylcholinesterase	Homo sapiens	96-117
32521451-0	2020	Glucopyranoside flavonoids isolated from leaves of Spinacia oleracea (spinach) inhibit the formation of advanced glycation end products (AGEs) and aldose reductase activity (RLAR).	Flavonoids	16-26	aldo-keto reductase family 1 member B1	Rattus norvegicus	147-163
32727785-3	2020	The current study aimed to explore all known flavonoids for their ability to inhibit PI3Kgamma.	Flavonoids	45-55	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	85-94
32727785-4	2020	MATERIALS AND METHODS: Virtual screening of flavonoids using molecular docking to the ATP binding site of PI3Kgamma was performed.	Flavonoids	44-54	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	106-115
32727785-8	2020	CONCLUSION: All 10 selected flavonoids are potential PI3Kgamma kinase inhibitors and anticancer agents.	Flavonoids	28-38	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	53-62
32219844-8	2020	Furthermore, dietary flavonoid supplementation ameliorated CKD and renal fibrosis through partially inhibiting the AhR activity via lowering the ACM levels.	Flavonoids	21-30	aryl hydrocarbon receptor	Rattus norvegicus	115-118
32219844-9	2020	The antagonistic effect of flavonoids on AhR was deeply influenced by the number and location of hydroxyl and glycosyl groups.	Flavonoids	27-37	aryl hydrocarbon receptor	Rattus norvegicus	41-44
32397768-3	2020	Quercetin, a flavonoid found in fruits and vegetables, has been demonstrated to exhibit cytoprotective effects through the induction of heme oxygenase (HO) -1, an enzyme involved in heme catabolism.	Flavonoids	13-22	heme oxygenase 1	Mus musculus	136-158
32627931-4	2020	The authors previously reported that FXR agonist xanthohumol (XN), the principal prenylated flavonoid in hops (Humulus lupulus), and its hydrogenated derivatives, alpha,beta-dihydroxanthohumol (DXN), and tetrahydroxanthohumol (TXN), ameliorated obesity-mediated insulin resistance, and cognitive impairment in mice fed a high-fat diet.	Flavonoids	92-101	nuclear receptor subfamily 1, group H, member 4	Mus musculus	37-40
32679511-0	2020	Investigation of the interaction of a polyamine-modified flavonoid with bovine serum albumin (BSA) by spectroscopic methods and molecular simulation.	Flavonoids	57-66	albumin	Homo sapiens	79-92
30979692-14	2020	Secondary metabolites with a high BDNF expression belonged to flavonoids, xanthone, coumarines, tannin, naphtalenes, terpenoids and carotenoid skeleton.	Flavonoids	62-72	brain derived neurotrophic factor	Homo sapiens	34-38
32312433-0	2020	Characterization of interaction between Bcl-2 oncogene promoter I-Motif DNA and flavonoids using electrospray ionization mass spectrometry and pressure-assisted capillary electrophoresis frontal analysis.	Flavonoids	80-90	BCL2 apoptosis regulator	Homo sapiens	40-45
32312433-11	2020	Taken all these observations into consideration, the specific binding of selected flavonoids to the Bcl-2 IM may prove to be a potential ligand for modulating Bcl-2 gene expression.	Flavonoids	82-92	BCL2 apoptosis regulator	Homo sapiens	100-105
32843908-6	2020	Flavonoids modulate key pathways involved in the Warburg phenotype including but not limited to PKM2, HK2, GLUT1 and HIF-1.	Flavonoids	0-10	pyruvate kinase M1/2	Homo sapiens	96-100
32752084-0	2020	Preparative Separation of Flavonoids from Goji Berries by Mixed-Mode Macroporous Adsorption Resins and Effect on Abeta-Expressing and Anti-Aging Genes.	Flavonoids	26-36	amyloid beta precursor protein	Homo sapiens	113-118
32722234-0	2020	Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators.	Flavonoids	33-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	92-107
32722234-8	2020	The main modifications that have been performed during last few years to generate flavonoid and terpenoid derivatives, bearing nitrogen moieties, such as aliphatic, aromatic and heterocycle amine, amide, and related functional groups, as well as their P-gp, MRP1 and BCRP inhibitory activities are reviewed and discussed.	Flavonoids	82-91	ATP binding cassette subfamily B member 1	Homo sapiens	252-256
32722234-8	2020	The main modifications that have been performed during last few years to generate flavonoid and terpenoid derivatives, bearing nitrogen moieties, such as aliphatic, aromatic and heterocycle amine, amide, and related functional groups, as well as their P-gp, MRP1 and BCRP inhibitory activities are reviewed and discussed.	Flavonoids	82-91	ATP binding cassette subfamily B member 1	Homo sapiens	258-262
32722234-8	2020	The main modifications that have been performed during last few years to generate flavonoid and terpenoid derivatives, bearing nitrogen moieties, such as aliphatic, aromatic and heterocycle amine, amide, and related functional groups, as well as their P-gp, MRP1 and BCRP inhibitory activities are reviewed and discussed.	Flavonoids	82-91	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	267-271
32751996-7	2020	Some of the flavonoids caused weak inhibition of OATP1A2 and MRP2.	Flavonoids	12-22	solute carrier organic anion transporter family member 1A2	Homo sapiens	49-56
32751996-7	2020	Some of the flavonoids caused weak inhibition of OATP1A2 and MRP2.	Flavonoids	12-22	ATP binding cassette subfamily C member 2	Homo sapiens	61-65
32751373-4	2020	In this work, we have used mass-spectrometry-based lipidomics to characterize the changes in the phospholipidome of proinflammatory human-macrophage-like cells (THP-1-derived and LPS+IFN-gamma-stimulated) incubated with non-cytotoxic concentrations of three flavonoids: quercetin, naringin and naringenin.	Flavonoids	258-268	GLI family zinc finger 2	Homo sapiens	161-166
32722164-0	2020	Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
32722164-9	2020	Therefore, this hypothesis paper describes the use of flavonoid supplements combined with vitamin D3 to activate Nrf2, which may be a potential target to prevent and/or decrease SARS-CoV-2 infection severity, reducing oxidative stress and inflammation, enhancing innate immunity, and downregulating ACE2 receptors.	Flavonoids	54-63	NFE2 like bZIP transcription factor 2	Homo sapiens	113-117
32722164-9	2020	Therefore, this hypothesis paper describes the use of flavonoid supplements combined with vitamin D3 to activate Nrf2, which may be a potential target to prevent and/or decrease SARS-CoV-2 infection severity, reducing oxidative stress and inflammation, enhancing innate immunity, and downregulating ACE2 receptors.	Flavonoids	54-63	angiotensin converting enzyme 2	Homo sapiens	299-303
32843908-6	2020	Flavonoids modulate key pathways involved in the Warburg phenotype including but not limited to PKM2, HK2, GLUT1 and HIF-1.	Flavonoids	0-10	hexokinase 2	Homo sapiens	102-105
32843908-6	2020	Flavonoids modulate key pathways involved in the Warburg phenotype including but not limited to PKM2, HK2, GLUT1 and HIF-1.	Flavonoids	0-10	solute carrier family 2 member 1	Homo sapiens	107-112
32843908-6	2020	Flavonoids modulate key pathways involved in the Warburg phenotype including but not limited to PKM2, HK2, GLUT1 and HIF-1.	Flavonoids	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-122
32765630-3	2020	The plant kingdom is extremely rich in a variety of compounds that are potent AChE inhibitors: flavonoids and other phenolic compounds have been recognized as promising Alzheimer"s treatment agents.	Flavonoids	95-105	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
32698689-6	2021	We performed molecular docking studies using 10 potential naturally occurring compounds (flavonoids/non-flavonoids) against the SARS-CoV-2 spike protein and compared their affinity with an FDA approved repurposed drug hydroxychloroquine (HCQ).	Flavonoids	89-99	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	139-144
32698689-6	2021	We performed molecular docking studies using 10 potential naturally occurring compounds (flavonoids/non-flavonoids) against the SARS-CoV-2 spike protein and compared their affinity with an FDA approved repurposed drug hydroxychloroquine (HCQ).	Flavonoids	104-114	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	139-144
32708255-0	2020	Flavonoids as Potential Drugs for VPS13-Dependent Rare Neurodegenerative Diseases.	Flavonoids	0-10	membrane morphogenesis protein VPS13	Saccharomyces cerevisiae S288C	34-39
32686994-0	2021	In silico analysis of polyphenols and flavonoids for design of human Nav1.7 inhibitors.	Flavonoids	38-48	sodium voltage-gated channel alpha subunit 9	Homo sapiens	69-75
32664242-4	2020	The results revealed that CTR, CTS, CTL, and CTF extracts have high phenol and flavonoid content, as well as a powerful antioxidant and reducing capacity.	Flavonoids	79-88	calcitonin receptor	Homo sapiens	26-29
32708687-0	2020	Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors.	Flavonoids	8-18	aryl hydrocarbon receptor	Homo sapiens	40-43
32708687-0	2020	Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors.	Flavonoids	8-18	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	87-91
32708687-3	2020	Here, we investigated the therapeutic potential of natural flavonoids as specific AhR (Aryl hydrocarbon Receptor) transcription factor antagonists in combination with BRAFi.	Flavonoids	59-69	aryl hydrocarbon receptor	Homo sapiens	82-85
32037847-4	2020	In this study, we examined whether FXR activation by schaftoside, a naturally-occurring flavonoid from Desmodium styracifolium, could protect mice against APAP-induced hepatotoxicity via regulation of oxidative stress and inflammation.	Flavonoids	88-97	nuclear receptor subfamily 1, group H, member 4	Mus musculus	35-38
32708426-3	2020	To develop a novel platform compound, we synthesized a flavonoid derivative, (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile (named DK4023) and characterized its inhibitory effects on the motility and MMP2 and MMP9 expression of highly metastatic MDA-MB-231 breast cancer cells.	Flavonoids	55-64	matrix metallopeptidase 2	Homo sapiens	235-239
32708426-3	2020	To develop a novel platform compound, we synthesized a flavonoid derivative, (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile (named DK4023) and characterized its inhibitory effects on the motility and MMP2 and MMP9 expression of highly metastatic MDA-MB-231 breast cancer cells.	Flavonoids	55-64	matrix metallopeptidase 9	Homo sapiens	244-248
32764989-0	2020	Effect of Malus asiatica Nakai Leaf Flavonoids on the Prevention of Esophageal Cancer in C57BL/6J Mice by Regulating the IL-17 Signaling Pathway.	Flavonoids	36-46	interleukin 17A	Mus musculus	121-126
32764989-1	2020	Background: The aim of this study was to observe the preventive effect of flavonoids extracted from Malus asiatica Nakai leaves (FMANL) on esophageal cancer in mice, especially the ability of FMANL to regulate the interleukin 17 (IL-17) signaling pathway during this process.	Flavonoids	74-84	interleukin 17A	Mus musculus	230-235
32708687-3	2020	Here, we investigated the therapeutic potential of natural flavonoids as specific AhR (Aryl hydrocarbon Receptor) transcription factor antagonists in combination with BRAFi.	Flavonoids	59-69	aryl hydrocarbon receptor	Homo sapiens	87-112
32708687-7	2020	As AhR antagonists, flavonoids counteracted a gene expression program associated with the acquisition of resistance and phenotype switching that leads to an invasive and EMT-like phenotype.	Flavonoids	20-30	aryl hydrocarbon receptor	Homo sapiens	3-6
32664242-4	2020	The results revealed that CTR, CTS, CTL, and CTF extracts have high phenol and flavonoid content, as well as a powerful antioxidant and reducing capacity.	Flavonoids	79-88	transthyretin	Homo sapiens	31-34
33088323-10	2020	Conclusion and implications: Auriculasin, a polyphenol flavonoid, can be considered as a potential inhibitor of SOS1-KRAS interaction.	Flavonoids	55-64	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	112-116
32650596-3	2020	We investigated whether treatment with sixteen flavonoid or xanthone compounds from C. tricuspidata could induce HO-1 expression in HT22 hippocampal cells, RAW264.7 macrophage, and BV2 microglia.	Flavonoids	47-56	heme oxygenase 1	Mus musculus	113-117
32635299-5	2020	Also, flavonoids such as ampelopsin and pinocembrin can inhibit mitochondrial dysfunction and neuronal death through the regulation of gene expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.	Flavonoids	6-16	NFE2 like bZIP transcription factor 2	Homo sapiens	158-201
32635299-5	2020	Also, flavonoids such as ampelopsin and pinocembrin can inhibit mitochondrial dysfunction and neuronal death through the regulation of gene expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.	Flavonoids	6-16	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
32635299-6	2020	Additionally, it is well established that many flavonoids exhibit anti-apoptosis and anti-inflammatory effects through cellular signaling pathways, such as those involving (ERK), glycogen synthase kinase-3beta (GSK-3beta), and (Akt), resulting in neuroprotection.	Flavonoids	47-57	mitogen-activated protein kinase 1	Homo sapiens	173-176
32635299-6	2020	Additionally, it is well established that many flavonoids exhibit anti-apoptosis and anti-inflammatory effects through cellular signaling pathways, such as those involving (ERK), glycogen synthase kinase-3beta (GSK-3beta), and (Akt), resulting in neuroprotection.	Flavonoids	47-57	glycogen synthase kinase 3 beta	Homo sapiens	179-209
32635299-6	2020	Additionally, it is well established that many flavonoids exhibit anti-apoptosis and anti-inflammatory effects through cellular signaling pathways, such as those involving (ERK), glycogen synthase kinase-3beta (GSK-3beta), and (Akt), resulting in neuroprotection.	Flavonoids	47-57	glycogen synthase kinase 3 alpha	Homo sapiens	211-220
32635299-6	2020	Additionally, it is well established that many flavonoids exhibit anti-apoptosis and anti-inflammatory effects through cellular signaling pathways, such as those involving (ERK), glycogen synthase kinase-3beta (GSK-3beta), and (Akt), resulting in neuroprotection.	Flavonoids	47-57	AKT serine/threonine kinase 1	Homo sapiens	228-231
32754278-9	2020	Through virtual screening of the protein interaction interface, Chrysin, a flavonoid compound extracted from Oroxylum indicum, was found to have the highest docking score to the COMP/TAGLN complex.	Flavonoids	75-84	cartilage oligomeric matrix protein	Mus musculus	178-182
32754278-9	2020	Through virtual screening of the protein interaction interface, Chrysin, a flavonoid compound extracted from Oroxylum indicum, was found to have the highest docking score to the COMP/TAGLN complex.	Flavonoids	75-84	transgelin	Mus musculus	183-188
33088323-10	2020	Conclusion and implications: Auriculasin, a polyphenol flavonoid, can be considered as a potential inhibitor of SOS1-KRAS interaction.	Flavonoids	55-64	KRAS proto-oncogene, GTPase	Homo sapiens	117-121
32426875-5	2020	Furthermore, among 12 major constituents of M. australis root, 10 flavonoids (especially 1) showed protection against carbon tetrachloride (CCl4 )-intoxicated HepG2 cell lines by decreased lactic dehydrogenase levels.	Flavonoids	66-76	C-C motif chemokine ligand 4	Homo sapiens	140-144
32426875-9	2020	Ten flavonoids from the root of this plant exhibited protection on CCl4 -intoxicated HepG2 cell lines.	Flavonoids	4-14	C-C motif chemokine ligand 4	Homo sapiens	67-71
32303124-0	2020	Frontline Science: Two flavonoid compounds attenuate allergic asthma by regulating epithelial barrier via G protein-coupled estrogen receptor: Probing a possible target for allergic inflammation.	Flavonoids	23-32	G protein-coupled estrogen receptor 1	Mus musculus	106-141
32442763-6	2020	This paper provides a review of redox reactions of various heme proteins, including catalase, some peroxidases, cytochrome P450, cytochrome c, myoglobin, and hemoglobin with flavonoids.	Flavonoids	174-184	catalase	Homo sapiens	84-92
32442763-6	2020	This paper provides a review of redox reactions of various heme proteins, including catalase, some peroxidases, cytochrome P450, cytochrome c, myoglobin, and hemoglobin with flavonoids.	Flavonoids	174-184	cytochrome c, somatic	Homo sapiens	129-141
32442763-6	2020	This paper provides a review of redox reactions of various heme proteins, including catalase, some peroxidases, cytochrome P450, cytochrome c, myoglobin, and hemoglobin with flavonoids.	Flavonoids	174-184	myoglobin	Homo sapiens	143-152
32303124-9	2020	These flavonoids significantly inhibited thymic stromal lymphopoietin (TSLP), increased occludin and restored E-cadherin in vivo and in vitro.	Flavonoids	6-16	thymic stromal lymphopoietin	Mus musculus	41-69
32303124-9	2020	These flavonoids significantly inhibited thymic stromal lymphopoietin (TSLP), increased occludin and restored E-cadherin in vivo and in vitro.	Flavonoids	6-16	thymic stromal lymphopoietin	Mus musculus	71-75
32303124-9	2020	These flavonoids significantly inhibited thymic stromal lymphopoietin (TSLP), increased occludin and restored E-cadherin in vivo and in vitro.	Flavonoids	6-16	occludin	Mus musculus	88-96
32303124-9	2020	These flavonoids significantly inhibited thymic stromal lymphopoietin (TSLP), increased occludin and restored E-cadherin in vivo and in vitro.	Flavonoids	6-16	cadherin 1	Mus musculus	110-120
32303124-10	2020	The effects of flavonoids on occludin and TSLP were not interfered by ICI182780 (estrogen receptor antagonist), while blocked by G15 (GPER antagonist).	Flavonoids	15-25	occludin	Mus musculus	29-37
32303124-10	2020	The effects of flavonoids on occludin and TSLP were not interfered by ICI182780 (estrogen receptor antagonist), while blocked by G15 (GPER antagonist).	Flavonoids	15-25	thymic stromal lymphopoietin	Mus musculus	42-46
32303124-10	2020	The effects of flavonoids on occludin and TSLP were not interfered by ICI182780 (estrogen receptor antagonist), while blocked by G15 (GPER antagonist).	Flavonoids	15-25	G protein-coupled estrogen receptor 1	Mus musculus	134-138
32303124-12	2020	siGPER and TEER assays suggested that GPER was pivotal for the flavonoids on the epithelial barrier integrity.	Flavonoids	63-73	G protein-coupled estrogen receptor 1	Mus musculus	2-6
32303124-14	2020	Our data demonstrated that 2 flavonoids in Radix Astragali could alleviate allergic asthma by protecting epithelial integrity via regulating GPER, and activating GPER might be a possible therapeutic strategy against allergic inflammation.	Flavonoids	29-39	G protein-coupled estrogen receptor 1	Mus musculus	141-145
32303124-14	2020	Our data demonstrated that 2 flavonoids in Radix Astragali could alleviate allergic asthma by protecting epithelial integrity via regulating GPER, and activating GPER might be a possible therapeutic strategy against allergic inflammation.	Flavonoids	29-39	G protein-coupled estrogen receptor 1	Mus musculus	162-166
32222576-7	2020	The flavonoid-enriched extract (FEE) inhibited xylene-induced mouse ear edema and cotton ball-induced rat granuloma, and suppressed LPS-induced over-release and/or overexpression of tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-1beta and interleukin-6 in RAW264.7 macrophages.	Flavonoids	4-13	tumor necrosis factor	Rattus norvegicus	182-209
33377721-0	2020	[Cuscuta chinensis flavonoids reduce the expression of GM-CSF in the testis of oligozoospermia rats].	Flavonoids	19-29	colony stimulating factor 2	Rattus norvegicus	55-61
33377721-1	2020	Objective: To investigate the effect of Cuscuta chinensis flavonoids (CCF) on the expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) in the testis of the rat with oligozoospermia (OZ).	Flavonoids	58-68	colony stimulating factor 2	Rattus norvegicus	150-156
33377721-9	2020	CONCLUSIONS: Cuscuta chinensis flavonoids can significantly down-regulate the expression of GM-CSF in the testis of the rats with cyclophosphamide-induced oligozoospermia.	Flavonoids	31-41	colony stimulating factor 2	Rattus norvegicus	92-98
32610479-6	2020	In addition, the most abundant transcription factor (TF) families in DEGs were bHLH and MYB, which have been shown to be widely involved in the regulation of plant flavonoids.	Flavonoids	164-174	MYB proto-oncogene, transcription factor	Homo sapiens	88-91
32222576-7	2020	The flavonoid-enriched extract (FEE) inhibited xylene-induced mouse ear edema and cotton ball-induced rat granuloma, and suppressed LPS-induced over-release and/or overexpression of tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-1beta and interleukin-6 in RAW264.7 macrophages.	Flavonoids	4-13	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	211-227
32222576-7	2020	The flavonoid-enriched extract (FEE) inhibited xylene-induced mouse ear edema and cotton ball-induced rat granuloma, and suppressed LPS-induced over-release and/or overexpression of tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-1beta and interleukin-6 in RAW264.7 macrophages.	Flavonoids	4-13	nitric oxide synthase 2	Rattus norvegicus	229-260
32222576-7	2020	The flavonoid-enriched extract (FEE) inhibited xylene-induced mouse ear edema and cotton ball-induced rat granuloma, and suppressed LPS-induced over-release and/or overexpression of tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-1beta and interleukin-6 in RAW264.7 macrophages.	Flavonoids	4-13	interleukin 1 beta	Rattus norvegicus	262-279
32222576-7	2020	The flavonoid-enriched extract (FEE) inhibited xylene-induced mouse ear edema and cotton ball-induced rat granuloma, and suppressed LPS-induced over-release and/or overexpression of tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-1beta and interleukin-6 in RAW264.7 macrophages.	Flavonoids	4-13	interleukin 6	Rattus norvegicus	284-297
32655263-6	2020	We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factor kappaB (NF-kappaB) and JAK/STAT signaling pathways.	Flavonoids	43-53	nitric oxide synthase 2	Homo sapiens	103-107
32802564-4	2020	Results showed that rich phenolic and flavonoid content of MELA had moderate dose dependent free radical scavenging activity (IC50: 62.0 mug/mL for DPPH  and 6.0 mug/mL for ABTS +).	Flavonoids	38-47	melanoma antigen	Mus musculus	59-63
32655263-6	2020	We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factor kappaB (NF-kappaB) and JAK/STAT signaling pathways.	Flavonoids	43-53	nuclear factor kappa B subunit 1	Homo sapiens	154-163
32396374-0	2020	Integrated Functional Omics Analysis of Flavonoid-Related Metabolism in AtMYB12 Transcript Factor Overexpressed Tomato.	Flavonoids	40-49	myb domain protein 12	Arabidopsis thaliana	72-79
32555682-3	2020	Quercetin, a naturally occurring flavonoid, reduces nuclear beta-catenin levels and reduces beta-catenin transcriptional activity.	Flavonoids	33-42	catenin beta 1	Homo sapiens	60-72
32555682-3	2020	Quercetin, a naturally occurring flavonoid, reduces nuclear beta-catenin levels and reduces beta-catenin transcriptional activity.	Flavonoids	33-42	catenin beta 1	Homo sapiens	92-104
32545268-4	2020	Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19.	Flavonoids	38-47	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	99-104
32530958-4	2020	Using a combination of surface plasmon resonance, differential scanning fluorimetry and fluorescence quenching studies, we provide evidence for direct binding of the dietary flavonoid fisetin to human SUMO1.	Flavonoids	174-183	small ubiquitin like modifier 1	Homo sapiens	201-206
32530958-7	2020	A series of differential scanning fluorimetry experiments suggest that high concentrations of fisetin result in destabilization and unfolding of SUMO1, presenting a molecular mechanism by which flavonoid binding affects its activity.	Flavonoids	194-203	small ubiquitin like modifier 1	Homo sapiens	145-150
32545268-4	2020	Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19.	Flavonoids	38-47	helicase for meiosis 1	Homo sapiens	114-122
32545268-4	2020	Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19.	Flavonoids	38-47	angiotensin converting enzyme 2	Homo sapiens	150-154
32469293-0	2021	Inhibition of fibrillation of human gammaD-crystallin by a flavonoid morin.	Flavonoids	59-68	crystallin gamma D	Homo sapiens	36-53
32469293-1	2021	To inhibit formation of amyloid fibrils by human gammaD-crystallin (HGD), a series of four flavonoids (quercertin, rutin, morin and hesperetin) was tested.	Flavonoids	91-101	homogentisate 1,2-dioxygenase	Homo sapiens	68-71
32521759-4	2020	Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-beta and other contributors of the complex process of metastatic spread.	Flavonoids	0-10	plasminogen activator, urokinase	Homo sapiens	330-333
32521759-4	2020	Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-beta and other contributors of the complex process of metastatic spread.	Flavonoids	0-10	plasminogen activator, urokinase receptor	Homo sapiens	334-338
32521759-4	2020	Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-beta and other contributors of the complex process of metastatic spread.	Flavonoids	0-10	transforming growth factor alpha	Homo sapiens	340-348
32395994-0	2020	Dual anti/pro-oxidant behaviors of flavonoids pertained to Cu (II) catalyzed tyrosine nitration of insulin receptor kinase domain in the anti-diabetic study.	Flavonoids	35-45	insulin	Homo sapiens	99-106
32273087-2	2020	The present study corroborates PPARgamma-mediated anti-asthmatic action of the flavonoid, galangin (norizalpinin).	Flavonoids	79-88	peroxisome proliferator activated receptor gamma	Homo sapiens	31-40
32221603-7	2020	When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (beta = -0.12, P = 0.017) and flavonoid (beta = -0.12, P = 0.013) intakes, findings that were inconsistent with the biomarker ratio results.	Flavonoids	159-168	interleukin 10	Homo sapiens	62-67
31765755-0	2020	Spectroscopy and molecular docking analysis reveal structural specificity of flavonoids in the inhibition of alpha-glucosidase activity.	Flavonoids	77-87	sucrase-isomaltase	Homo sapiens	109-126
31765755-10	2020	This work confirmed two novel alpha-glucosidase inhibitors and provided the structure-function relationship of flavonoids in inhibition of alpha-glucosidase activity.	Flavonoids	111-121	sucrase-isomaltase	Homo sapiens	30-47
31765755-10	2020	This work confirmed two novel alpha-glucosidase inhibitors and provided the structure-function relationship of flavonoids in inhibition of alpha-glucosidase activity.	Flavonoids	111-121	sucrase-isomaltase	Homo sapiens	139-156
32125580-6	2020	CONCLUSION: Protein synthesis and flavonoid biosynthesis were regulated by SCL3 in the context of GA in Arabidopsis thaliana root system identified by comprehensive bioinformatic analyses.	Flavonoids	34-43	scarecrow-like 3	Arabidopsis thaliana	75-79
32452573-7	2020	The phenolic compounds and flavonoids in EAv were identified for the first time, using flow injection with electrospray negative ionization-ion trap tandem mass spectrometry analysis (FIA-ESI-IT-MSn ).	Flavonoids	27-37	moesin	Mus musculus	195-198
32159797-4	2020	Further concentration-dependent studies identified 7 OAT1 inhibitors and 10 OAT3 inhibitors with IC50 values of < 10 muM, and most of them were flavonoids, the most commonly ingested polyphenolic compounds in the diet and herbal products.	Flavonoids	144-154	solute carrier family 22 member 6	Rattus norvegicus	53-57
32279813-4	2020	In vitro and in vivo studies have demonstrated the therapeutic effect of Quercetin, a ubiquitous flavonoid widely distributed in plants, on neuropathy, by modulating the expression of NRF-2-dependent antioxidant responsive elements.	Flavonoids	97-106	NFE2 like bZIP transcription factor 2	Rattus norvegicus	184-189
32173584-8	2020	Mechanistic studies are summarized, which indicate that flavonoids, terpenoids, and anthranoids can inhibit starch-digesting enzymes, aldose reductase, MAP kinases, NFkappaB, and/or IkappaB kinases implicated in energy metabolism, beta-cells, and immunity.	Flavonoids	56-66	aldo-keto reductase family 1 member B	Homo sapiens	134-150
32159797-4	2020	Further concentration-dependent studies identified 7 OAT1 inhibitors and 10 OAT3 inhibitors with IC50 values of < 10 muM, and most of them were flavonoids, the most commonly ingested polyphenolic compounds in the diet and herbal products.	Flavonoids	144-154	solute carrier family 22 member 8	Rattus norvegicus	76-80
31578905-3	2020	It has been reported that inhibition of CYP2A6 and CYP2A13 enzymes by flavonoids constituents could be an aids in smoking cessation.	Flavonoids	70-80	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	40-46
31578905-3	2020	It has been reported that inhibition of CYP2A6 and CYP2A13 enzymes by flavonoids constituents could be an aids in smoking cessation.	Flavonoids	70-80	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	51-58
31578905-7	2020	Molecular docking indicated that CYP2A13 enzyme has strong hydrophobic interaction with ring B of flavonoids compared to CYP2A6 enzyme.	Flavonoids	98-108	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	33-40
31578905-0	2020	Structure-activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids.	Flavonoids	98-108	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	87-94
31578905-7	2020	Molecular docking indicated that CYP2A13 enzyme has strong hydrophobic interaction with ring B of flavonoids compared to CYP2A6 enzyme.	Flavonoids	98-108	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	121-127
31578905-0	2020	Structure-activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids.	Flavonoids	98-108	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	76-82
32547398-0	2020	Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids.	Flavonoids	118-128	solute carrier family 22 member 8	Homo sapiens	60-64
32463711-0	2020	Screening inhibitory effects of selected flavonoids on human recombinant aldose reductase enzyme: in vitro and in silico study.	Flavonoids	41-51	aldo-keto reductase family 1 member B	Homo sapiens	73-89
32547398-4	2020	In the present study, OAT3-mediated uptake of enalaprilat was first characterized, and the inhibition of OAT3 transport activity was then examined for a number of flavonoid and drug molecules with diverse structures.	Flavonoids	163-172	solute carrier family 22 member 8	Homo sapiens	105-109
32547398-5	2020	A varying degree of inhibition potency was demonstrated for flavonoids, with IC50 values ranging from 0.03 to 22.6 microM against OAT3 transport activity.	Flavonoids	60-70	solute carrier family 22 member 8	Homo sapiens	130-134
32547398-8	2020	For the polar center, hydroxyl groups present in flavonoids could act as either hydrogen bond donors or acceptors and the number and position of hydroxyl groups were critical drivers for inhibition potency, while carboxyl groups present in some drugs could form ionic bridges with OAT3.	Flavonoids	49-59	solute carrier family 22 member 8	Homo sapiens	281-285
32394708-5	2020	Transcriptome analysis also showed that the BnTT2 mutation inhibited the expression of genes in the phenylpropanoid and flavonoid biosynthetic pathway, which might be regulated by the complex of BnTT2, BnTT8 and BnTTG1.	Flavonoids	120-129	transcription factor TT8	Brassica napus	202-207
32455624-4	2020	Recently, flavonoids from plants have been reported to have inhibitory effects on NF-kappaB activities.	Flavonoids	10-20	nuclear factor kappa B subunit 1	Homo sapiens	82-91
32364726-7	2020	This is the first investigation studying the in vitro inhibitory effect of a panel of flavonoids against human liver FBPase, thus representing a potentially important step for the search and design of novel inhibitors of this enzyme.	Flavonoids	86-96	fructose-bisphosphatase 1	Homo sapiens	111-123
32087226-2	2020	Among the compounds isolated, flavonoids calycosin (5) and 8-O-methylretusin (6) were found to potently and selectively inhibit hMAO-B (IC50 = 0.24 and 0.23 muM, respectively) but not hMAO-A with high selectivity index (SI) values (SI = 293.8 and 81.3, respectively).	Flavonoids	30-40	monoamine oxidase B	Homo sapiens	128-134
32430735-7	2020	Bet v 1 and its homologues were shown to bind flavonoids with high affinity, but the specificity appears to differ between homologues from different species.	Flavonoids	46-56	delta/notch like EGF repeat containing	Homo sapiens	0-3
32430735-10	2020	In contrast, Bet v 1 and hazelnut Cor a 1 showed very similar binding behavior towards other flavonoids such as quercetin, genistein, apigenin, daidzein, and resveratrol.	Flavonoids	93-103	delta/notch like EGF repeat containing	Homo sapiens	13-16
32087226-2	2020	Among the compounds isolated, flavonoids calycosin (5) and 8-O-methylretusin (6) were found to potently and selectively inhibit hMAO-B (IC50 = 0.24 and 0.23 muM, respectively) but not hMAO-A with high selectivity index (SI) values (SI = 293.8 and 81.3, respectively).	Flavonoids	30-40	latexin	Homo sapiens	157-160
31896456-0	2020	Interaction mechanism of flavonoids and bovine beta-lactoglobulin: Experimental and molecular modelling studies.	Flavonoids	25-35	beta-lactoglobulin	Bos taurus	47-65
32087226-2	2020	Among the compounds isolated, flavonoids calycosin (5) and 8-O-methylretusin (6) were found to potently and selectively inhibit hMAO-B (IC50 = 0.24 and 0.23 muM, respectively) but not hMAO-A with high selectivity index (SI) values (SI = 293.8 and 81.3, respectively).	Flavonoids	30-40	monoamine oxidase A	Homo sapiens	184-190
31896456-1	2020	In this study, the quantitative structure-affinity relationship of 28 flavonoids with bovine beta-lactoglobulin (beta-lg) was investigated based on experimental and theoretical methods.	Flavonoids	70-80	beta-lactoglobulin	Bos taurus	93-111
32415123-4	2020	We show that mutations in RDR6, SGS3, or DCL4 suppress the anthocyanin defect of tt19 by pushing carbon towards flavonoid biosynthesis.	Flavonoids	112-121	RNA-dependent RNA polymerase 6	Arabidopsis thaliana	26-30
31896456-1	2020	In this study, the quantitative structure-affinity relationship of 28 flavonoids with bovine beta-lactoglobulin (beta-lg) was investigated based on experimental and theoretical methods.	Flavonoids	70-80	beta-lactoglobulin	Bos taurus	113-120
31896456-2	2020	The binding constants (Ka) of these flavonoids with beta-lg were systematically compared by spectrofluorimetry, and a multivariate linear model (R2 = 0.8769, Q2 = 0.7963) was established that could explain the effect of the structure parameters of flavonoids on their affinity (lgKa) for beta-lg.	Flavonoids	36-46	beta-lactoglobulin	Bos taurus	52-59
31896456-2	2020	The binding constants (Ka) of these flavonoids with beta-lg were systematically compared by spectrofluorimetry, and a multivariate linear model (R2 = 0.8769, Q2 = 0.7963) was established that could explain the effect of the structure parameters of flavonoids on their affinity (lgKa) for beta-lg.	Flavonoids	36-46	beta-lactoglobulin	Bos taurus	288-295
31896456-2	2020	The binding constants (Ka) of these flavonoids with beta-lg were systematically compared by spectrofluorimetry, and a multivariate linear model (R2 = 0.8769, Q2 = 0.7963) was established that could explain the effect of the structure parameters of flavonoids on their affinity (lgKa) for beta-lg.	Flavonoids	248-258	beta-lactoglobulin	Bos taurus	52-59
32415123-4	2020	We show that mutations in RDR6, SGS3, or DCL4 suppress the anthocyanin defect of tt19 by pushing carbon towards flavonoid biosynthesis.	Flavonoids	112-121	XS domain-containing protein / XS zinc finger domain-containing protein-like protein	Arabidopsis thaliana	32-36
32415123-4	2020	We show that mutations in RDR6, SGS3, or DCL4 suppress the anthocyanin defect of tt19 by pushing carbon towards flavonoid biosynthesis.	Flavonoids	112-121	dicer-like 4	Arabidopsis thaliana	41-45
32415123-6	2020	This synergy between mutations in components of the RDR6-SGS3-DCL4 siRNA system and the flavonoid pathway reveals genetic/epigenetic mechanisms regulating metabolic fluxes.	Flavonoids	88-97	RNA-dependent RNA polymerase 6	Arabidopsis thaliana	52-56
32415123-6	2020	This synergy between mutations in components of the RDR6-SGS3-DCL4 siRNA system and the flavonoid pathway reveals genetic/epigenetic mechanisms regulating metabolic fluxes.	Flavonoids	88-97	XS domain-containing protein / XS zinc finger domain-containing protein-like protein	Arabidopsis thaliana	57-61
32415123-6	2020	This synergy between mutations in components of the RDR6-SGS3-DCL4 siRNA system and the flavonoid pathway reveals genetic/epigenetic mechanisms regulating metabolic fluxes.	Flavonoids	88-97	dicer-like 4	Arabidopsis thaliana	62-66
32259555-0	2020	Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects.	Flavonoids	26-36	solute carrier organic anion transporter family member 1B1	Homo sapiens	44-51
32509154-2	2020	Apigenin (AP) is a flavonoid with an outstanding antioxidant activity.	Flavonoids	19-28	LIM homeobox protein 2	Mus musculus	0-8
32259555-7	2020	Among them, kaempferol decreased the concentration most significantly, by 54.17 %, which indicated that flavonoids may alleviate bosentan-induced liver injury by inhibiting OATP1B1-mediated bosentan uptake.	Flavonoids	104-114	solute carrier organic anion transporter family member 1B1	Homo sapiens	173-180
32259555-8	2020	Furthermore, the pharmacophore model indicated the hydrogen bond acceptors and hydrogen bond donors may play critical role in the potency of flavonoids inhibition on OATP1B1.	Flavonoids	141-151	solute carrier organic anion transporter family member 1B1	Homo sapiens	166-173
32509154-2	2020	Apigenin (AP) is a flavonoid with an outstanding antioxidant activity.	Flavonoids	19-28	LIM homeobox protein 2	Mus musculus	10-12
32017949-0	2020	Moslea Herba flavonoids alleviated influenza A virus-induced pulmonary endothelial barrier disruption via suppressing NOX4/NF-kappaB/MLCK pathway.	Flavonoids	13-23	NADPH oxidase 4	Homo sapiens	118-122
32327603-6	2020	Moreover, from this screen, we identified that the flavonoid compound apigenin can relieve the MPO-mediated oxidative stress and inhibit the ferroptosis of neuronal cells.	Flavonoids	51-60	myeloperoxidase	Mus musculus	95-98
32403270-4	2020	In this investigation, twenty synthesized flavonoid derivatives, defined as KKR compounds were screened for their inhibitory potentials against human MAO-A and MAO-B isozymes.	Flavonoids	42-51	monoamine oxidase A	Homo sapiens	150-155
32403270-4	2020	In this investigation, twenty synthesized flavonoid derivatives, defined as KKR compounds were screened for their inhibitory potentials against human MAO-A and MAO-B isozymes.	Flavonoids	42-51	monoamine oxidase B	Homo sapiens	160-165
32017949-0	2020	Moslea Herba flavonoids alleviated influenza A virus-induced pulmonary endothelial barrier disruption via suppressing NOX4/NF-kappaB/MLCK pathway.	Flavonoids	13-23	nuclear factor kappa B subunit 1	Homo sapiens	123-132
32017949-0	2020	Moslea Herba flavonoids alleviated influenza A virus-induced pulmonary endothelial barrier disruption via suppressing NOX4/NF-kappaB/MLCK pathway.	Flavonoids	13-23	myosin light chain kinase 3	Homo sapiens	133-137
32455198-2	2020	In this study, aglycone, mono-, and diglycosides of quercetin and cyanidin were selected to examine the effects of the structural feature on the bioavailability of flavonoids using hexose transporters SGLT1 and GLUT2 in a Caco-2 BBe1 cell model.	Flavonoids	164-174	solute carrier family 5 member 1	Homo sapiens	201-206
32169417-5	2020	For example, inhibition of hepatic CD38 and activation of AHR, e.g., by dietary flavonoids may beneficially affect NAFLD.	Flavonoids	80-90	aryl hydrocarbon receptor	Homo sapiens	58-61
32006472-0	2020	Investigation of the interactions between flavonoids and human organic anion transporting polypeptide 1B1 using fluorescent substrate and 3D-QSAR analysis.	Flavonoids	42-52	solute carrier organic anion transporter family member 1B1	Homo sapiens	63-105
32006472-3	2020	Therefore, investigation of the interactions between OATP1B1 and flavonoids could be of great significance.	Flavonoids	65-75	solute carrier organic anion transporter family member 1B1	Homo sapiens	53-60
32006472-4	2020	In the present study, 25 common flavonoids were investigated for their interactions with OATP1B1 using the fluorescent substrate 2",7"-dichlorofluorescein (DCF) and three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis.	Flavonoids	32-42	solute carrier organic anion transporter family member 1B1	Homo sapiens	89-96
32006472-6	2020	Inhibition assay for flavonoids on OATP1B1-mediated DCF uptake was performed and their IC50 values were determined upon which reliable and predictive CoMFA (q2 = 0.604, r2 = 0.841) and CoMSIA (q2 = 0.534, r2 = 0.807) models were developed.	Flavonoids	21-31	solute carrier organic anion transporter family member 1B1	Homo sapiens	35-42
32006472-7	2020	Our experimental and computational results showed that flavonoid aglycones interacted with OATP1B1 much stronger than their glycosides such as 3-O- and 7-O-glycosides as bulky hydrophilic and hydrogen-bond forming substituents at C-3 and C-7 positions on rings A and C were unfavorable for their binding.	Flavonoids	55-64	solute carrier organic anion transporter family member 1B1	Homo sapiens	91-98
32006472-10	2020	The obtained information and 3D-QSAR models could be useful for elucidating and predicting the interactions between flavonoids and human OATP1B1.	Flavonoids	116-126	solute carrier organic anion transporter family member 1B1	Homo sapiens	137-144
32126287-7	2020	Our results demonstrate that MYB13 protein functions as a transcription factor to regulate the expression of genes involved in auxin response and flavonoid biosynthesis through direct binding with their promoters.	Flavonoids	146-155	myb domain protein 13	Arabidopsis thaliana	29-34
32165083-7	2020	Therefore, the natural dietary flavonoid myricetin has potential to be developed into a novel anti-HSV agent targeting both virus gD protein and cellular EGFR/PI3K/Akt pathway.	Flavonoids	31-40	epidermal growth factor receptor	Homo sapiens	154-158
32165083-7	2020	Therefore, the natural dietary flavonoid myricetin has potential to be developed into a novel anti-HSV agent targeting both virus gD protein and cellular EGFR/PI3K/Akt pathway.	Flavonoids	31-40	AKT serine/threonine kinase 1	Homo sapiens	164-167
31637846-7	2020	Further transcriptomic profiling revealed that the targeted mutations of BnTT8 resulted in the broad suppression of phenylpropanoid/flavonoid biosynthesis genes, which indicated a much more complex molecular mechanism underlying seed color formation in rapeseed than in Arabidopsis and other Brassica species.	Flavonoids	132-141	transcription factor TT8	Brassica napus	73-78
32400767-11	2020	Modulation of MMP-9 by a natural flavonoid like naringenin seems to be a novel approach to target diabetic neuropathic pain.	Flavonoids	33-42	matrix metallopeptidase 9	Rattus norvegicus	14-19
31816533-5	2020	These observations are the first evidence that SlMYC2 plays vital roles in MJ-induced fruit resistance to Botrytis cinerea, possibly by regulating defence enzyme activities, SlPRs expression, alpha-tomatine, special phenolic acids and flavonoid compounds.	Flavonoids	235-244	transcription factor MYC2	Solanum lycopersicum	47-53
32226990-0	2020	Exploring the structure-activity relationship and interaction mechanism of flavonoids and alpha-glucosidase based on experimental analysis and molecular docking studies.	Flavonoids	75-85	sucrase-isomaltase	Homo sapiens	90-107
32253400-0	2020	Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways.	Flavonoids	0-10	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	156-161
32425923-0	2020	Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?	Flavonoids	79-88	mannosidase endo-alpha	Homo sapiens	24-28
31893608-11	2020	Thus, compound 4 is a potent novel flavonoid-based hCAII inhibitor and may be useful for further anti-CAII design and development.	Flavonoids	35-44	carbonic anhydrase 2	Homo sapiens	51-56
31893608-11	2020	Thus, compound 4 is a potent novel flavonoid-based hCAII inhibitor and may be useful for further anti-CAII design and development.	Flavonoids	35-44	carbonic anhydrase 2	Homo sapiens	52-56
32337630-0	2020	Chemotherapeutic Efficacy Enhancement in P-gp-Overexpressing Cancer Cells by Flavonoid-Loaded Polymeric Micelles.	Flavonoids	77-86	phosphoglycolate phosphatase	Homo sapiens	41-45
32377296-6	2020	At the same time, flavonoid treatment significantly reduced the malondialdehyde content in cells and increased the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px).	Flavonoids	18-27	catalase	Homo sapiens	125-133
32357395-0	2020	Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats.	Flavonoids	15-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	25-57
32377296-6	2020	At the same time, flavonoid treatment significantly reduced the malondialdehyde content in cells and increased the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px).	Flavonoids	18-27	catalase	Homo sapiens	135-138
32377296-6	2020	At the same time, flavonoid treatment significantly reduced the malondialdehyde content in cells and increased the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px).	Flavonoids	18-27	superoxide dismutase 1	Homo sapiens	163-166
32377296-6	2020	At the same time, flavonoid treatment significantly reduced the malondialdehyde content in cells and increased the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px).	Flavonoids	18-27	GS homeobox 1	Homo sapiens	182-185
32377296-6	2020	At the same time, flavonoid treatment significantly reduced the malondialdehyde content in cells and increased the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px).	Flavonoids	18-27	GS homeobox 1	Homo sapiens	216-219
32328497-7	2020	Articles retrieved showed that traditional antioxidation diet is one of the most approved explanations of inhibition of aromatase by phytonutrients of flavonoid derivatives.	Flavonoids	151-160	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	120-129
32208672-3	2020	Herein, we demonstrate the potential of two naturally occurring flavonoids (quercetin and baicalein) to inhibit fibrillation of wild type SOD1 with the aid of series of biophysical techniques.	Flavonoids	64-74	superoxide dismutase 1	Homo sapiens	138-142
32208672-5	2020	Interestingly, our ThT binding assay, TEM and SDS PAGE experiments suggest that these flavonoids also disintegrate the fibrils into shorter fragments but does not completely depolymerize them into monomers.	Flavonoids	86-96	MFT2	Homo sapiens	38-41
32208672-6	2020	Binding parameters obtained from UV-Vis suggest that these flavonoids bind moderately to native SOD1 dimer and have different binding sites.	Flavonoids	59-69	superoxide dismutase 1	Homo sapiens	96-100
32208672-7	2020	Docking of these flavonoids with non- native monomer, non-native trimer and oligomer derived from 11 residues segment of SOD1 indicate that both quercetin and baicalein can bind to these species and thus, can arrest the elongation of fibrils by blocking the fibrillar core regions on the intermediate species formed during aggregation of SOD1.	Flavonoids	17-27	superoxide dismutase 1	Homo sapiens	121-125
32208672-7	2020	Docking of these flavonoids with non- native monomer, non-native trimer and oligomer derived from 11 residues segment of SOD1 indicate that both quercetin and baicalein can bind to these species and thus, can arrest the elongation of fibrils by blocking the fibrillar core regions on the intermediate species formed during aggregation of SOD1.	Flavonoids	17-27	superoxide dismutase 1	Homo sapiens	338-342
32208672-8	2020	MTT assay data revealed that both the flavonoids reduced the cytotoxicity of SOD1 fibrils.	Flavonoids	38-48	superoxide dismutase 1	Homo sapiens	77-81
32208672-9	2020	Experimental data also show the anti-amyloidogenic potential of both the flavonoids against A4V SOD1 mutant fibrillation.	Flavonoids	73-83	superoxide dismutase 1	Homo sapiens	96-100
32328497-8	2020	Flavonoids compete for the oxygen provided by the heme moiety of aromatase in the course of aromatase-catalyzed conversion of steroid precursors to estrogens.	Flavonoids	0-10	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	65-74
32328497-8	2020	Flavonoids compete for the oxygen provided by the heme moiety of aromatase in the course of aromatase-catalyzed conversion of steroid precursors to estrogens.	Flavonoids	0-10	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	92-101
32268868-0	2021	In silico discovery of novel flavonoids as poly ADP ribose polymerase (PARP) inhibitors.	Flavonoids	29-39	poly(ADP-ribose) polymerase 1	Homo sapiens	43-69
32268868-0	2021	In silico discovery of novel flavonoids as poly ADP ribose polymerase (PARP) inhibitors.	Flavonoids	29-39	poly(ADP-ribose) polymerase 1	Homo sapiens	71-75
32268868-2	2021	OBJECTIVES: In this study we performed virtual screening of 329 flavonoids obtained from Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target (NPACT) database to identify novel PARP inhibitors.	Flavonoids	64-74	poly(ADP-ribose) polymerase 1	Homo sapiens	193-197
32268868-4	2021	RESULTS: Fifteen out of 329 flavonoids achieved better docking score as compared to rucaparib which is an FDA approved PARP inhibitor.	Flavonoids	28-38	poly(ADP-ribose) polymerase 1	Homo sapiens	119-123
32268584-8	2020	The epigenetic targets of the actions of flavonoids include oncogenes and tumor suppressor genes, indirectly controlled through the regulation of epigenetic enzymes such as DNA methyltransferase (DNMT), histone acetyltransferase (HAT), and histone deacetylase (HDAC).	Flavonoids	41-51	DNA methyltransferase 1	Homo sapiens	173-194
32268584-8	2020	The epigenetic targets of the actions of flavonoids include oncogenes and tumor suppressor genes, indirectly controlled through the regulation of epigenetic enzymes such as DNA methyltransferase (DNMT), histone acetyltransferase (HAT), and histone deacetylase (HDAC).	Flavonoids	41-51	DNA methyltransferase 1	Homo sapiens	196-200
31157594-0	2020	Spectral and molecular docking studies on the interaction of three flavonoids with bovine serum albumin.	Flavonoids	67-77	albumin	Homo sapiens	90-103
32149508-1	2020	Procyanidin B3 is a natural flavonoid composed of two catechins connected via a C4alpha-C8" bond.	Flavonoids	28-37	complement C4A (Rodgers blood group)	Homo sapiens	80-87
32149508-2	2020	The couplings of catechin derivatives, promoted by Lewis acids, have been widely applied to the syntheses of procyanidin B3 and related flavonoids because the reactions construct the C4alpha-C8" bond in a highly stereo- and regioselective manner.	Flavonoids	136-146	complement C4A (Rodgers blood group)	Homo sapiens	183-190
31278615-6	2020	Our study presents two preliminary findings: (a) in HaVSMCs, FOLFIRI treatment significantly induces oxidative damage to both DNA and protein, leading to a dramatic increase in caspase-dependent apoptotic death through P53-mediated Caspase3-dependent mitochondrial apoptosis, and results in TNF-alpha/Caspase8-mediated necrotic death, and (b) flavonoids not only regulate the expression of genes encoding antioxidant enzymes and increase DNA damage but also limit programmed and necrotic cell death processes in HaVSMCs.	Flavonoids	343-353	tumor protein p53	Homo sapiens	219-222
32083508-3	2020	Therefore, we hypothesized that a standard anti-inflammatory agent-melatonin (MEL), and the flavonoid-rich fractions from Chromolaena odorata (FRFC) could counteract the deleterious effects of IL-1beta, TNF-alpha, and NO after consumption of AFB1.	Flavonoids	92-101	interleukin 1 alpha	Rattus norvegicus	193-201
31999847-0	2020	Higher intakes of flavonoids are associated with lower salivary IL-1beta and maintenance of periodontal health 3 to 4 years after scaling and root planing.	Flavonoids	18-28	interleukin 1 alpha	Homo sapiens	64-72
31999847-5	2020	RESULTS: Flavonoid intake was inversely associated with PD (p=0.042) and salivary IL-1beta concentration (p=0.015) after adjustment for multiple confounders.	Flavonoids	9-18	interleukin 1 alpha	Homo sapiens	82-90
31999847-9	2020	CONCLUSION: Higher flavonoid intake is associated with lower IL-1beta.	Flavonoids	19-28	interleukin 1 alpha	Homo sapiens	61-69
32083508-3	2020	Therefore, we hypothesized that a standard anti-inflammatory agent-melatonin (MEL), and the flavonoid-rich fractions from Chromolaena odorata (FRFC) could counteract the deleterious effects of IL-1beta, TNF-alpha, and NO after consumption of AFB1.	Flavonoids	92-101	tumor necrosis factor	Rattus norvegicus	203-212
32078899-0	2020	CmMYB8 encodes an R2R3 MYB transcription factor which represses lignin and flavonoid synthesis in chrysanthemum.	Flavonoids	75-84	MYB proto-oncogene, transcription factor	Homo sapiens	2-5
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	interleukin 1 alpha	Homo sapiens	154-162
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	interleukin 2	Homo sapiens	164-168
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	interleukin 6	Homo sapiens	173-177
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	interferon gamma	Homo sapiens	180-196
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	interferon gamma	Homo sapiens	198-207
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	colony stimulating factor 2	Homo sapiens	210-258
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	colony stimulating factor 2	Homo sapiens	260-266
32233673-4	2021	Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha).	Flavonoids	56-66	tumor necrosis factor	Homo sapiens	302-311
32256354-0	2020	Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment.	Flavonoids	0-9	signal transducer and activator of transcription 3	Mus musculus	89-94
32235536-0	2020	Galangin, a Flavonoid from Lesser Galangal, Induced Apoptosis via p53-Dependent Pathway in Ovarian Cancer Cells.	Flavonoids	12-21	tumor protein p53	Homo sapiens	66-69
32256354-3	2020	Four Epimedii Herba-derived flavonoid compounds, namely, limonianin, epimedokoreanin B, icaritin, and desmethylicaritin, inhibited CD163 expression and interleukin (IL)-10 production, which are known M2 markers, suggesting that these compounds inhibit M2 polarization.	Flavonoids	28-37	CD163 antigen	Mus musculus	131-136
32256354-3	2020	Four Epimedii Herba-derived flavonoid compounds, namely, limonianin, epimedokoreanin B, icaritin, and desmethylicaritin, inhibited CD163 expression and interleukin (IL)-10 production, which are known M2 markers, suggesting that these compounds inhibit M2 polarization.	Flavonoids	28-37	interleukin 10	Mus musculus	152-171
32044269-4	2020	Cyanidin, a key flavonoid inhibits IL-17A/IL-17 receptor A (IL-17RA) interaction and alleviates progression and disease severity of psoriasis and asthma.	Flavonoids	16-25	interleukin 17A	Rattus norvegicus	35-41
32197377-0	2020	Effect of Terpenoids and Flavonoids Isolated from Baccharis conferta Kunth on TPA-Induced Ear Edema in Mice.	Flavonoids	25-35	promotion susceptibility QTL 1	Mus musculus	78-81
32044269-4	2020	Cyanidin, a key flavonoid inhibits IL-17A/IL-17 receptor A (IL-17RA) interaction and alleviates progression and disease severity of psoriasis and asthma.	Flavonoids	16-25	interleukin 17 receptor A	Rattus norvegicus	60-67
32257052-2	2020	We have previously shown by network analysis of proteomic data that the flavonoids epigallocatechin gallate (EGCG) and fisetin (FIS) efficiently downregulated pro-tumor cytokines released by HCC through inhibition of Akt/mTOR/RPS6 phospho-signaling.	Flavonoids	72-82	AKT serine/threonine kinase 1	Homo sapiens	217-220
32210536-8	2020	In this paper, we summarized the potent inhibitors, including bisaryl structure-based compounds, flavonoids, crown ethers, and carboranes, for treating TTR-related amyloid diseases and the combination modes of some compounds binding to TTR protein.	Flavonoids	97-107	transthyretin	Homo sapiens	152-155
32257052-2	2020	We have previously shown by network analysis of proteomic data that the flavonoids epigallocatechin gallate (EGCG) and fisetin (FIS) efficiently downregulated pro-tumor cytokines released by HCC through inhibition of Akt/mTOR/RPS6 phospho-signaling.	Flavonoids	72-82	mechanistic target of rapamycin kinase	Homo sapiens	221-225
32257052-2	2020	We have previously shown by network analysis of proteomic data that the flavonoids epigallocatechin gallate (EGCG) and fisetin (FIS) efficiently downregulated pro-tumor cytokines released by HCC through inhibition of Akt/mTOR/RPS6 phospho-signaling.	Flavonoids	72-82	ribosomal protein S6	Homo sapiens	226-230
32183155-7	2020	Indeed, flavonoids having a 5,7-dihydroxychromen-4-one backbone tend to increase the expression of the steroidogenic acute regulatory protein (StAR), being critical for the entry of cholesterol into the mitochondria, leading to increased testosterone production from testis Leydig cells.	Flavonoids	8-18	steroidogenic acute regulatory protein	Homo sapiens	103-141
32183155-7	2020	Indeed, flavonoids having a 5,7-dihydroxychromen-4-one backbone tend to increase the expression of the steroidogenic acute regulatory protein (StAR), being critical for the entry of cholesterol into the mitochondria, leading to increased testosterone production from testis Leydig cells.	Flavonoids	8-18	steroidogenic acute regulatory protein	Homo sapiens	143-147
32168835-5	2020	Flavonoids have the ability to promote clearance of Abeta peptides and inhibit tau phosphorylation by the mTOR/autophagy signaling pathway.	Flavonoids	0-10	mechanistic target of rapamycin kinase	Homo sapiens	106-110
32210536-8	2020	In this paper, we summarized the potent inhibitors, including bisaryl structure-based compounds, flavonoids, crown ethers, and carboranes, for treating TTR-related amyloid diseases and the combination modes of some compounds binding to TTR protein.	Flavonoids	97-107	transthyretin	Homo sapiens	236-239
32155912-0	2020	Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes.	Flavonoids	55-64	albumin	Homo sapiens	94-101
32328272-0	2020	Dietary flavonoid myricetin inhibits invasion and migration of radioresistant lung cancer cells (A549-IR) by suppressing MMP-2 and MMP-9 expressions through inhibition of the FAK-ERK signaling pathway.	Flavonoids	8-17	matrix metallopeptidase 2	Homo sapiens	121-126
32328272-0	2020	Dietary flavonoid myricetin inhibits invasion and migration of radioresistant lung cancer cells (A549-IR) by suppressing MMP-2 and MMP-9 expressions through inhibition of the FAK-ERK signaling pathway.	Flavonoids	8-17	matrix metallopeptidase 9	Homo sapiens	131-136
32328272-0	2020	Dietary flavonoid myricetin inhibits invasion and migration of radioresistant lung cancer cells (A549-IR) by suppressing MMP-2 and MMP-9 expressions through inhibition of the FAK-ERK signaling pathway.	Flavonoids	8-17	protein tyrosine kinase 2	Homo sapiens	175-178
32328272-0	2020	Dietary flavonoid myricetin inhibits invasion and migration of radioresistant lung cancer cells (A549-IR) by suppressing MMP-2 and MMP-9 expressions through inhibition of the FAK-ERK signaling pathway.	Flavonoids	8-17	mitogen-activated protein kinase 1	Homo sapiens	179-182
32143602-0	2020	A systematic analysis of natural alpha-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology.	Flavonoids	67-77	sucrase-isomaltase	Homo sapiens	33-50
32143602-5	2020	METHODS: In the present study, a systematic method combining ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology was developed to screen alpha-glucosidase inhibitors from flavonoids of RS, and explore the underlying mechanism for the treatment of T2D.	Flavonoids	181-191	sucrase-isomaltase	Homo sapiens	147-164
32155912-0	2020	Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes.	Flavonoids	55-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	106-121
32155912-5	2020	Therefore, in this in vitro study, we investigated the interactions of 24 microbial flavonoid metabolites with human serum albumin and cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes.	Flavonoids	84-93	albumin	Homo sapiens	123-130
32155912-5	2020	Therefore, in this in vitro study, we investigated the interactions of 24 microbial flavonoid metabolites with human serum albumin and cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes.	Flavonoids	84-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	135-150
32155912-5	2020	Therefore, in this in vitro study, we investigated the interactions of 24 microbial flavonoid metabolites with human serum albumin and cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes.	Flavonoids	84-93	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	152-158
32521910-0	2020	Anticancer effects of catechin flavonoid in human glioma cells are mediated via autophagy induction, cell cycle arrest, inhibition of cell migration and invasion and targeting MAPK/ERK signalling pathway.	Flavonoids	31-40	mitogen-activated protein kinase 1	Homo sapiens	181-184
31986326-2	2020	Spina Gleditsiae is a traditional Chinese anti-inflammatory medicine, from which a large number of flavonoids, such as 5-O-methyldihydroquercetin (GS1) and cilicicone B (GS2), were isolated in the present study.	Flavonoids	99-109	pseudouridine 5'-phosphatase	Mus musculus	147-150
31894470-5	2020	We show that these flavonoids can disaggregate Chain A and Chain B of hIAPP to reduce the extended conformation by binding with two regions of hIAPP, Leu12-Ala13-Asn14 and Asn31-Val32-Gly33-Ser34-Asn35, with the inhibitory ability of Genistein > Rutin > Quercetin > EGCG > Silibinin.	Flavonoids	19-29	islet amyloid polypeptide	Homo sapiens	70-75
31894470-5	2020	We show that these flavonoids can disaggregate Chain A and Chain B of hIAPP to reduce the extended conformation by binding with two regions of hIAPP, Leu12-Ala13-Asn14 and Asn31-Val32-Gly33-Ser34-Asn35, with the inhibitory ability of Genistein > Rutin > Quercetin > EGCG > Silibinin.	Flavonoids	19-29	islet amyloid polypeptide	Homo sapiens	143-148
31894470-7	2020	Mutations of eight key residues remarkably affected by the flavonoids indicate that the secondary structures of the hIAPP pentamer change from beta-sheet to be random coil, thereby to destroy its structural stability; moreover, the 28th (Ser), 12th (Leu) and 32nd (Val) amino acids exhibit significant effects on structural stability of the hIAPP pentamer, providing an important hint that these amino acids can be considered as potential targets for design of new candidate inhibitors against hIAPP oligomers.	Flavonoids	59-69	islet amyloid polypeptide	Homo sapiens	116-121
31894470-7	2020	Mutations of eight key residues remarkably affected by the flavonoids indicate that the secondary structures of the hIAPP pentamer change from beta-sheet to be random coil, thereby to destroy its structural stability; moreover, the 28th (Ser), 12th (Leu) and 32nd (Val) amino acids exhibit significant effects on structural stability of the hIAPP pentamer, providing an important hint that these amino acids can be considered as potential targets for design of new candidate inhibitors against hIAPP oligomers.	Flavonoids	59-69	islet amyloid polypeptide	Homo sapiens	341-346
31894470-7	2020	Mutations of eight key residues remarkably affected by the flavonoids indicate that the secondary structures of the hIAPP pentamer change from beta-sheet to be random coil, thereby to destroy its structural stability; moreover, the 28th (Ser), 12th (Leu) and 32nd (Val) amino acids exhibit significant effects on structural stability of the hIAPP pentamer, providing an important hint that these amino acids can be considered as potential targets for design of new candidate inhibitors against hIAPP oligomers.	Flavonoids	59-69	islet amyloid polypeptide	Homo sapiens	341-346
31927393-3	2020	Clarification of the interaction mechanisms between serum albumin and bioactive components (such as heme and flavonoid) is important to develop effective carriers for encapsulation of heme and suppression of its toxicity.	Flavonoids	109-118	albumin	Homo sapiens	58-65
31059805-7	2020	Treatment of human U251 and TG1 glioblastoma cells with both flavonoids also modulated negatively the expression of mRNA for IL-6 and IL-10 and positively the expression of mRNA for TNF characterizing changes to the immune regulatory profile.	Flavonoids	61-71	interleukin 6	Homo sapiens	125-129
31059805-7	2020	Treatment of human U251 and TG1 glioblastoma cells with both flavonoids also modulated negatively the expression of mRNA for IL-6 and IL-10 and positively the expression of mRNA for TNF characterizing changes to the immune regulatory profile.	Flavonoids	61-71	interleukin 10	Homo sapiens	134-139
31059805-7	2020	Treatment of human U251 and TG1 glioblastoma cells with both flavonoids also modulated negatively the expression of mRNA for IL-6 and IL-10 and positively the expression of mRNA for TNF characterizing changes to the immune regulatory profile.	Flavonoids	61-71	tumor necrosis factor	Homo sapiens	182-185
30898030-7	2020	Here, we report molecular dynamics data from 16 flavonoid-COX-2 complexes performed for 50 nanoseconds each that demonstrates key structural and dynamic aspects of flavonoid-based COX inhibition in light of observed experimental facts.	Flavonoids	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
30898030-7	2020	Here, we report molecular dynamics data from 16 flavonoid-COX-2 complexes performed for 50 nanoseconds each that demonstrates key structural and dynamic aspects of flavonoid-based COX inhibition in light of observed experimental facts.	Flavonoids	164-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
32109679-5	2020	In the present study, the protective effects of flavonoids from S. uncinata (SUF) and its major compound robustaflavone-4"-dimethyl ether (RDE) against lipopolysaccharide (LPS)-induced ALI were investigated in mice and in neutrophils.The results showed that both SUF and RDE had the same inhibition on LPS-induced lung edema and neutrophil infiltration as well as the increased levels of IL-6, TNF-alpha, P-selectin and ICAM-1 in serum of LPS-challenged mice.	Flavonoids	48-58	interleukin 6	Mus musculus	388-392
32194676-0	2020	Total flavonoids suppress lung cancer growth via the COX-2-mediated Wnt/beta-catenin signaling pathway.	Flavonoids	6-16	prostaglandin-endoperoxide synthase 2	Mus musculus	53-58
32194676-0	2020	Total flavonoids suppress lung cancer growth via the COX-2-mediated Wnt/beta-catenin signaling pathway.	Flavonoids	6-16	catenin (cadherin associated protein), beta 1	Mus musculus	72-84
32121322-9	2020	Natural polyphenolic compounds, including flavonoids and non-flavonoids, execute their anticarcinogenic mechanism through upregulating tumor suppressors and autophagy by modulating canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) signaling pathways.	Flavonoids	42-52	beclin 1	Homo sapiens	192-200
32121322-9	2020	Natural polyphenolic compounds, including flavonoids and non-flavonoids, execute their anticarcinogenic mechanism through upregulating tumor suppressors and autophagy by modulating canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) signaling pathways.	Flavonoids	42-52	beclin 1	Homo sapiens	231-239
32121322-9	2020	Natural polyphenolic compounds, including flavonoids and non-flavonoids, execute their anticarcinogenic mechanism through upregulating tumor suppressors and autophagy by modulating canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) signaling pathways.	Flavonoids	61-71	beclin 1	Homo sapiens	192-200
32121322-9	2020	Natural polyphenolic compounds, including flavonoids and non-flavonoids, execute their anticarcinogenic mechanism through upregulating tumor suppressors and autophagy by modulating canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) signaling pathways.	Flavonoids	61-71	beclin 1	Homo sapiens	231-239
31986558-6	2020	The flavonoids showed significant antioxidant capacities, suppressed nitric oxide production in lipopolysaccharide (LPS)-treated RAW 264.7 cells, and reduced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) protein production increased by LPS treatment.	Flavonoids	4-14	nitric oxide synthase 2, inducible	Mus musculus	158-189
31986558-6	2020	The flavonoids showed significant antioxidant capacities, suppressed nitric oxide production in lipopolysaccharide (LPS)-treated RAW 264.7 cells, and reduced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) protein production increased by LPS treatment.	Flavonoids	4-14	nitric oxide synthase 2, inducible	Mus musculus	191-195
31986558-6	2020	The flavonoids showed significant antioxidant capacities, suppressed nitric oxide production in lipopolysaccharide (LPS)-treated RAW 264.7 cells, and reduced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) protein production increased by LPS treatment.	Flavonoids	4-14	cytochrome c oxidase II, mitochondrial	Mus musculus	217-222
31670603-1	2020	Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1beta (CPT1beta).	Flavonoids	71-80	uncoupling protein 1	Homo sapiens	139-159
31670603-1	2020	Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1beta (CPT1beta).	Flavonoids	71-80	uncoupling protein 1	Homo sapiens	161-165
31853544-7	2020	Furthermore, we show that the plant flavonoid dihydromyricetin inhibits human DHP activity.	Flavonoids	36-45	dihydropyrimidinase	Homo sapiens	78-81
32109679-5	2020	In the present study, the protective effects of flavonoids from S. uncinata (SUF) and its major compound robustaflavone-4"-dimethyl ether (RDE) against lipopolysaccharide (LPS)-induced ALI were investigated in mice and in neutrophils.The results showed that both SUF and RDE had the same inhibition on LPS-induced lung edema and neutrophil infiltration as well as the increased levels of IL-6, TNF-alpha, P-selectin and ICAM-1 in serum of LPS-challenged mice.	Flavonoids	48-58	tumor necrosis factor	Mus musculus	394-403
32109679-5	2020	In the present study, the protective effects of flavonoids from S. uncinata (SUF) and its major compound robustaflavone-4"-dimethyl ether (RDE) against lipopolysaccharide (LPS)-induced ALI were investigated in mice and in neutrophils.The results showed that both SUF and RDE had the same inhibition on LPS-induced lung edema and neutrophil infiltration as well as the increased levels of IL-6, TNF-alpha, P-selectin and ICAM-1 in serum of LPS-challenged mice.	Flavonoids	48-58	selectin, platelet	Mus musculus	405-415
32102401-1	2020	In this study, the effect of lotus leaf flavonoids (LLF) on carbon tetrachloride (CCl4)-induced liver injury in mice was studied.	Flavonoids	40-50	chemokine (C-C motif) ligand 4	Mus musculus	82-86
32109679-5	2020	In the present study, the protective effects of flavonoids from S. uncinata (SUF) and its major compound robustaflavone-4"-dimethyl ether (RDE) against lipopolysaccharide (LPS)-induced ALI were investigated in mice and in neutrophils.The results showed that both SUF and RDE had the same inhibition on LPS-induced lung edema and neutrophil infiltration as well as the increased levels of IL-6, TNF-alpha, P-selectin and ICAM-1 in serum of LPS-challenged mice.	Flavonoids	48-58	intercellular adhesion molecule 1	Mus musculus	420-426
32065826-2	2020	This study was performed to evaluate the ability of total flavonoid extract from hawthorn (TFH) to improve TNF-alpha-evoked intestinal epithelial barrier deficit.	Flavonoids	58-67	tumor necrosis factor	Homo sapiens	107-116
32019887-4	2020	XPR1-mediated Pi efflux was inhibited by reducing cellular InsP8 synthesis, either genetically (knockout [KO] of diphosphoinositol pentakisphosphate kinases [PPIP5Ks] that synthesize InsP8) or pharmacologically [cell treatment with 2.5 microM dietary flavonoid or 10 microM N2-(m-trifluorobenzyl), N6-(p-nitrobenzyl) purine], to inhibit inositol hexakisphosphate kinases upstream of PPIP5Ks.	Flavonoids	251-260	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	0-4
32128354-2	2020	In terms of down-regulating the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and matrix metalloproteinases (MMPs), pre-treatment with the flavonoid baicalein reportedly protects articular chondrocytes against the cytotoxicity of IL-1beta.	Flavonoids	167-176	nitric oxide synthase 2	Homo sapiens	46-77
32128354-2	2020	In terms of down-regulating the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and matrix metalloproteinases (MMPs), pre-treatment with the flavonoid baicalein reportedly protects articular chondrocytes against the cytotoxicity of IL-1beta.	Flavonoids	167-176	nitric oxide synthase 2	Homo sapiens	79-83
32128354-2	2020	In terms of down-regulating the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and matrix metalloproteinases (MMPs), pre-treatment with the flavonoid baicalein reportedly protects articular chondrocytes against the cytotoxicity of IL-1beta.	Flavonoids	167-176	interleukin 6	Homo sapiens	86-104
32128354-2	2020	In terms of down-regulating the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and matrix metalloproteinases (MMPs), pre-treatment with the flavonoid baicalein reportedly protects articular chondrocytes against the cytotoxicity of IL-1beta.	Flavonoids	167-176	matrix metallopeptidase 3	Homo sapiens	137-141
32128354-2	2020	In terms of down-regulating the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and matrix metalloproteinases (MMPs), pre-treatment with the flavonoid baicalein reportedly protects articular chondrocytes against the cytotoxicity of IL-1beta.	Flavonoids	167-176	interleukin 1 alpha	Homo sapiens	258-266
31983197-0	2020	Colorimetric Differentiation of Flavonoids Based on Effective Reactivation of Acetylcholinesterase Induced by Different Affnities between Flavonoids and Metal Ions.	Flavonoids	32-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-98
31983197-0	2020	Colorimetric Differentiation of Flavonoids Based on Effective Reactivation of Acetylcholinesterase Induced by Different Affnities between Flavonoids and Metal Ions.	Flavonoids	138-148	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-98
32068963-5	2020	Accordingly, PHYB2Y252H -overexpressing fruits developed more chloroplasts containing voluminous grana at the green stage and overaccumulated carotenoids, tocopherols, flavonoids and ascorbate in ripe fruits compared to both wildtype and PHYB2-overexpressing lines.	Flavonoids	168-178	phytochrome B2	Solanum lycopersicum	13-18
32079281-0	2020	CsCYT75B1, a Citrus CYTOCHROME P450 Gene, Is Involved in Accumulation of Antioxidant Flavonoids and Induces Drought Tolerance in Transgenic Arabidopsis.	Flavonoids	85-95	CYP702A7P	Arabidopsis thaliana	20-35
32079281-2	2020	Our earlier transcriptome data revealed that a CYTOCHROME P450 gene of Citrus sinensis (CsCYT75B1) was associated with flavonoid metabolism and was highly induced after drought stress.	Flavonoids	119-128	CYP702A7P	Arabidopsis thaliana	47-62
31883893-4	2020	The results clearly demonstrated that the naphthodianthrones, biflavones and most of flavonoids in SJW displayed strong to moderate inhibition on PL.	Flavonoids	85-95	pancreatic lipase	Homo sapiens	146-148
32054115-7	2020	Furthermore, ectopic expression of AtPAP1 evoked expression of early and late biosynthetic genes of the general phenylpropanoid and flavonoid pathways that include phenylalanine ammonia-lyase (PAL), cinnamate-4-hydroxylase (C4H), 4-coumarate CoA ligase (4CL), chalcone isomerase (CHI), and quinate hydroxycinnamoyl transferase (HCT), which suggests these genes might be transcriptional targets of AtPAP1 in black nightshade.	Flavonoids	132-141	phosphatidic acid phosphatase 1	Arabidopsis thaliana	35-41
32054115-9	2020	Our data demonstrate that a major anthocyanin biosynthetic regulator, AtPAP1, can induce accumulation of anthocyanins in the heterologous system of black nightshade through the conserved flavonoid biosynthesis pathway in plants.	Flavonoids	187-196	phosphatidic acid phosphatase 1	Arabidopsis thaliana	70-76
32030477-1	2020	MAIN CONCLUSION: The phosphorylation status of MYB75 at T-131 affects protein stability, flavonoid profiles, and patterns of gene expression.	Flavonoids	89-98	production of anthocyanin pigment 1	Arabidopsis thaliana	47-52
32045633-4	2020	Chemical composition research showed that 19 flavonoids were identified in SFE, and pharmacological research showed that SFE could significantly ameliorate spatial learning and memory ability.	Flavonoids	45-55	membrane metallo-endopeptidase	Rattus norvegicus	75-78
32030477-2	2020	The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is known to act as a positive transcriptional regulator of genes required for flavonoid and anthocyanin biosynthesis.	Flavonoids	160-169	production of anthocyanin pigment 1	Arabidopsis thaliana	37-62
32030477-2	2020	The Arabidopsis transcription factor Myeloblastosis protein 75 (MYB75, AT1G56650) is known to act as a positive transcriptional regulator of genes required for flavonoid and anthocyanin biosynthesis.	Flavonoids	160-169	production of anthocyanin pigment 1	Arabidopsis thaliana	64-69
32030477-12	2020	In addition, we describe how ectopic over-expression of different phosphovariant forms of MYB75 (MYB75WT, MYB75T131A, and MYB75T131E) affects flavonoid biochemical profiles and global changes of gene expression in the corresponding transgenic Arabidopsis plants.	Flavonoids	142-151	production of anthocyanin pigment 1	Arabidopsis thaliana	90-95
32030477-12	2020	In addition, we describe how ectopic over-expression of different phosphovariant forms of MYB75 (MYB75WT, MYB75T131A, and MYB75T131E) affects flavonoid biochemical profiles and global changes of gene expression in the corresponding transgenic Arabidopsis plants.	Flavonoids	142-151	production of anthocyanin pigment 1	Arabidopsis thaliana	97-104
32047858-2	2020	Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine.	Flavonoids	60-70	solute carrier family 22 member 12	Homo sapiens	79-84
32047858-0	2020	Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate.	Flavonoids	28-38	solute carrier family 22 member 12	Homo sapiens	83-102
33728270-10	2021	APE showed antioxidant activity by scavenging DPPH free radicals; this may be due to the presence of phenolic compounds, particularly flavonoids.	Flavonoids	134-144	apurinic/apyrimidinic endonuclease 1	Mus musculus	0-3
32047858-0	2020	Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate.	Flavonoids	28-38	solute carrier family 22 member 12	Homo sapiens	104-109
31756459-0	2020	Heterotropic activation of flavonoids on cytochrome P450 3A4: a case example of alleviating dronedarone-induced cytotoxicity.	Flavonoids	27-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-60
32047858-0	2020	Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate.	Flavonoids	28-38	solute carrier family 22 member 12	Homo sapiens	110-118
31192773-5	2020	Results: The results indicate that the flavonoids increased total PTEN levels in a dose-dependent manner.	Flavonoids	39-49	phosphatase and tensin homolog	Homo sapiens	66-70
31626358-0	2020	Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis.	Flavonoids	37-46	myb domain protein 4	Arabidopsis thaliana	12-16
31626358-6	2020	In addition, MYB4 can also inhibit flavonoid accumulation by repressing expression of the gene encoding Arogenate Dehydratase 6 (ADT6), which catalyzes the final step in the biosynthesis of phenylalanine, the precursor for flavonoid biosynthesis.	Flavonoids	35-44	myb domain protein 4	Arabidopsis thaliana	13-17
31626358-6	2020	In addition, MYB4 can also inhibit flavonoid accumulation by repressing expression of the gene encoding Arogenate Dehydratase 6 (ADT6), which catalyzes the final step in the biosynthesis of phenylalanine, the precursor for flavonoid biosynthesis.	Flavonoids	35-44	arogenate dehydratase 6	Arabidopsis thaliana	104-127
31626358-6	2020	In addition, MYB4 can also inhibit flavonoid accumulation by repressing expression of the gene encoding Arogenate Dehydratase 6 (ADT6), which catalyzes the final step in the biosynthesis of phenylalanine, the precursor for flavonoid biosynthesis.	Flavonoids	35-44	arogenate dehydratase 6	Arabidopsis thaliana	129-133
31626358-6	2020	In addition, MYB4 can also inhibit flavonoid accumulation by repressing expression of the gene encoding Arogenate Dehydratase 6 (ADT6), which catalyzes the final step in the biosynthesis of phenylalanine, the precursor for flavonoid biosynthesis.	Flavonoids	223-232	myb domain protein 4	Arabidopsis thaliana	13-17
31626358-6	2020	In addition, MYB4 can also inhibit flavonoid accumulation by repressing expression of the gene encoding Arogenate Dehydratase 6 (ADT6), which catalyzes the final step in the biosynthesis of phenylalanine, the precursor for flavonoid biosynthesis.	Flavonoids	223-232	arogenate dehydratase 6	Arabidopsis thaliana	104-127
31626358-6	2020	In addition, MYB4 can also inhibit flavonoid accumulation by repressing expression of the gene encoding Arogenate Dehydratase 6 (ADT6), which catalyzes the final step in the biosynthesis of phenylalanine, the precursor for flavonoid biosynthesis.	Flavonoids	223-232	arogenate dehydratase 6	Arabidopsis thaliana	129-133
31626358-8	2020	We suggest that MYB4 plays dual roles in modulating the flavonoid biosynthetic pathway in Arabidopsis.	Flavonoids	56-65	myb domain protein 4	Arabidopsis thaliana	16-20
31918290-0	2020	Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-kappaB p65 and MAPK signaling pathways in septic AKI mice.	Flavonoids	0-9	Rous sarcoma oncogene	Mus musculus	78-81
31719153-4	2020	Two of these genes, ACC and KAT5, have been previously characterized with respect to their involvement in lipid metabolism, but no information concerning their relationship to flavonoid biosynthesis is available.	Flavonoids	176-185	peroxisomal 3-keto-acyl-CoA thiolase 2	Arabidopsis thaliana	28-32
31655123-0	2020	Human CYP1A1 inhibition by flavonoids.	Flavonoids	27-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-12
31655123-6	2020	In silico studies have shown that, Phe224 and other aromatic residues in the human CYP1A1 active site play an important role in flavonoid-CYP interaction, through a pi/pi stacking between the aminoacid and the flavonoid C-ring.	Flavonoids	128-137	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
31655123-6	2020	In silico studies have shown that, Phe224 and other aromatic residues in the human CYP1A1 active site play an important role in flavonoid-CYP interaction, through a pi/pi stacking between the aminoacid and the flavonoid C-ring.	Flavonoids	210-219	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
31756459-4	2020	However, little is known about activation effects of flavonoids on CYP3A4.	Flavonoids	53-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73
31756459-5	2020	The aim of this study was to investigate activation of CYP3A4 by flavonoids, explore the molecular mechanism, and assess the biological effects on dronedarone (DND) induced toxicity.	Flavonoids	65-75	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	55-61
31756459-9	2020	Finally, the pharmacophore model suggested B aromatic ring, hydrophobic groups at 7-position and hydrogen bond acceptors at 4-position may play a vital role in activation of flavonoids on CYP3A4.	Flavonoids	174-184	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	188-194
32019201-5	2020	The components present in CSP identified by LC-ESI-Q-TOF-MS were found to be flavonoids and fatty acids.	Flavonoids	77-87	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	26-29
31968628-0	2020	Study on Structure Activity Relationship of Natural Flavonoids against Thrombin by Molecular Docking Virtual Screening Combined with Activity Evaluation In Vitro.	Flavonoids	52-62	coagulation factor II, thrombin	Homo sapiens	71-79
31932824-0	2020	Citrus flavonoids suppress IL-5 and ROS through distinct pathways in PMA/ionomycin-induced EL-4 cells.	Flavonoids	7-17	interleukin 5	Mus musculus	27-31
32047577-4	2020	The Citrus flavonoid naringenin (NAR) presents structural similarity with the natural SIRT1 activator resveratrol.	Flavonoids	11-20	sirtuin 1	Mus musculus	86-91
31998556-0	2020	Flavonoids from Epimedium pubescens: extraction and mechanism, antioxidant capacity and effects on CAT and GSH-Px of Drosophila melanogaster.	Flavonoids	0-10	Catalase	Drosophila melanogaster	99-102
31998556-8	2020	Then, effects of flavonoids on catalase (CAT) and glutathione peroxidase (GSH-Px) in D. melanogaster were investigated for the first time.	Flavonoids	17-27	Catalase	Drosophila melanogaster	31-39
31998556-8	2020	Then, effects of flavonoids on catalase (CAT) and glutathione peroxidase (GSH-Px) in D. melanogaster were investigated for the first time.	Flavonoids	17-27	Catalase	Drosophila melanogaster	41-44
31930238-0	2020	Cuscuta chinensis flavonoids down-regulate the DNA methylation of the H19/Igf2 imprinted control region and estrogen receptor alpha promoter of the testis in bisphenol A exposed mouse offspring.	Flavonoids	18-28	H19, imprinted maternally expressed transcript	Mus musculus	70-73
31930238-0	2020	Cuscuta chinensis flavonoids down-regulate the DNA methylation of the H19/Igf2 imprinted control region and estrogen receptor alpha promoter of the testis in bisphenol A exposed mouse offspring.	Flavonoids	18-28	insulin-like growth factor 2	Mus musculus	74-78
31930238-0	2020	Cuscuta chinensis flavonoids down-regulate the DNA methylation of the H19/Igf2 imprinted control region and estrogen receptor alpha promoter of the testis in bisphenol A exposed mouse offspring.	Flavonoids	18-28	estrogen receptor 1 (alpha)	Mus musculus	108-131
31968628-2	2020	In view of this, it is worthwhile to establish a method to screen thrombin inhibitors (such as natural flavonoid-type inhibitors) as well as investigate their structure activity relationships.	Flavonoids	103-112	coagulation factor II, thrombin	Homo sapiens	66-74
31968628-6	2020	Noteworthy, introduction of OH groups at different positions on flavonoids either decreased or increased anti-thrombin potential.	Flavonoids	64-74	coagulation factor II, thrombin	Homo sapiens	110-118
31968628-8	2020	Purposively, the established molecular docking virtual screening method is not limited to exploring flavonoid structure activity relationships to anti-thrombin activity but also usefully discovering other natural active constituents.	Flavonoids	100-109	coagulation factor II, thrombin	Homo sapiens	151-159
31998556-8	2020	Then, effects of flavonoids on catalase (CAT) and glutathione peroxidase (GSH-Px) in D. melanogaster were investigated for the first time.	Flavonoids	17-27	PHGPx	Drosophila melanogaster	50-72
31998556-12	2020	For females, oral administration of flavonoids improved CAT and GSH-Px activities by 13.58% and 5.18%, respectively.	Flavonoids	36-46	Catalase	Drosophila melanogaster	56-59
31704512-6	2020	Nevertheless, the molecular processes remain to be exposed, flavonoids are found to cause a change in the Abeta and tau aggregation pathway to generate non-toxic aggregates.	Flavonoids	60-70	microtubule associated protein tau	Homo sapiens	116-119
31998556-13	2020	For males, oral administration of flavonoids increased CAT and GSH-Px activities by 13.90% and 5.65%, respectively.	Flavonoids	34-44	Catalase	Drosophila melanogaster	55-58
31998556-15	2020	Flavonoids of E. pubescens showed great potential for becoming a natural antioxidant because of their antiradical ability and effects on CAT and GSH-Px of the model organism.	Flavonoids	0-10	Catalase	Drosophila melanogaster	137-140
31758928-2	2020	Oxidation of tryptophan (Trp) residues of a major gamma-crystallin namely human gammaD-crystallin (HGD) was found to be inhibited by a naturally occurring flavonoid hesperetin at relatively low concentration mostly due to its antioxidant activity.	Flavonoids	155-164	homogentisate 1,2-dioxygenase	Homo sapiens	50-103
31758928-3	2020	Further the molecular interactions between HGD and hesperetin were elucidated on the basis of the quenching of Trp fluorescence of the protein by the flavonoid.	Flavonoids	150-159	homogentisate 1,2-dioxygenase	Homo sapiens	43-46
31929529-4	2020	Here, some compounds, many of them flavonoids, were identified in the hydroethanolic extract from the leaves of C. americana (HECA) by LC-HRMS and LC-MS/MS.	Flavonoids	35-45	hdc homolog, cell cycle regulator	Mus musculus	126-130
32009975-5	2019	Interestingly, many of the environmental (e.g., pollutants and other toxicants) and nutritional (e.g., flavonoids, carotenoids) factors influencing aging and mitochondrial function also directly or indirectly affect the activity of a highly conserved transcription factor, the Aryl hydrocarbon Receptor (AhR).	Flavonoids	103-113	aryl hydrocarbon receptor	Homo sapiens	277-302
32009975-5	2019	Interestingly, many of the environmental (e.g., pollutants and other toxicants) and nutritional (e.g., flavonoids, carotenoids) factors influencing aging and mitochondrial function also directly or indirectly affect the activity of a highly conserved transcription factor, the Aryl hydrocarbon Receptor (AhR).	Flavonoids	103-113	aryl hydrocarbon receptor	Homo sapiens	304-307
31926084-8	2020	All the extracts showed high phenolic and flavonoid contents, which correlated with their antioxidant, anticholinesterase, alpha-glucosidase and alpha-amylase activities.	Flavonoids	42-51	sucrase isomaltase (alpha-glucosidase)	Mus musculus	123-140
31919453-4	2020	Using dorsal tail curvature as the assay readout, three major chemical classes (steroids, coumarins, flavonoids) were identified from the Spectrum library as the most promising candidates to be tested on human PKD1 cystic cells.	Flavonoids	101-111	polycystin 1, transient receptor potential channel interacting	Homo sapiens	210-214
31421182-18	2020	Dalpanitin and vicenin-3, two of the flavonoids isolated from Derris scandens gave MICs of 23 mug mL-1 against S. aureus.	Flavonoids	37-47	L1 cell adhesion molecule	Mus musculus	98-102
32085882-6	2020	Emerging evidence supports the efficacy of dietary plant flavonoids in prevention and attenuation of obesity and diabetes by the protection and proliferation of pancreatic beta-cells and improvement of their insulin secretory function via activation of cAMP/PKA signaling pathway as well as in the improvement of insulin sensitivity in the peripheral metabolic tisssues for glucose uptake and utilization via inhibition of inflammation, lipotoxicity and oxidative stress.	Flavonoids	57-67	insulin	Homo sapiens	208-215
31894701-0	2021	Inhibition of melanin production and tyrosinase activity by flavonoids isolated from Loranthus acutifolius.	Flavonoids	60-70	tyrosinase	Mus musculus	37-47
32085882-6	2020	Emerging evidence supports the efficacy of dietary plant flavonoids in prevention and attenuation of obesity and diabetes by the protection and proliferation of pancreatic beta-cells and improvement of their insulin secretory function via activation of cAMP/PKA signaling pathway as well as in the improvement of insulin sensitivity in the peripheral metabolic tisssues for glucose uptake and utilization via inhibition of inflammation, lipotoxicity and oxidative stress.	Flavonoids	57-67	insulin	Homo sapiens	313-320
32085882-7	2020	These flavonoids improve GLUT-4 expression and translocation to plasma membrane by activation of insulin-sensitive PI3K/Akt signaling and insulin-independent AMPK, SIRT-1 and MOR activation pathways for regulation of glucose homeostasis, and improve fat oxidation and reduce lipid synthesis by regulation of related genes for lipid homeostasis in the body of obese diabetic animals.	Flavonoids	6-16	solute carrier family 2 member 4	Homo sapiens	25-31
32085882-7	2020	These flavonoids improve GLUT-4 expression and translocation to plasma membrane by activation of insulin-sensitive PI3K/Akt signaling and insulin-independent AMPK, SIRT-1 and MOR activation pathways for regulation of glucose homeostasis, and improve fat oxidation and reduce lipid synthesis by regulation of related genes for lipid homeostasis in the body of obese diabetic animals.	Flavonoids	6-16	insulin	Homo sapiens	97-104
32085882-7	2020	These flavonoids improve GLUT-4 expression and translocation to plasma membrane by activation of insulin-sensitive PI3K/Akt signaling and insulin-independent AMPK, SIRT-1 and MOR activation pathways for regulation of glucose homeostasis, and improve fat oxidation and reduce lipid synthesis by regulation of related genes for lipid homeostasis in the body of obese diabetic animals.	Flavonoids	6-16	sirtuin 1	Homo sapiens	164-170
32085882-7	2020	These flavonoids improve GLUT-4 expression and translocation to plasma membrane by activation of insulin-sensitive PI3K/Akt signaling and insulin-independent AMPK, SIRT-1 and MOR activation pathways for regulation of glucose homeostasis, and improve fat oxidation and reduce lipid synthesis by regulation of related genes for lipid homeostasis in the body of obese diabetic animals.	Flavonoids	6-16	opioid receptor mu 1	Homo sapiens	175-178
32491127-0	2020	Plasma Protein Binding of Herbal-Flavonoids to Human Serum Albumin and Their Anti-proliferative Activities.	Flavonoids	33-43	albumin	Homo sapiens	53-66
32597888-17	2020	CONCLUSION: The micronized purified flavonoid fraction (Detralex) at a standard daily dose of 1000 mg in a combination with compression therapy irrespective of the surgical intervention performed resulted in a significant dynamic decrease in the volume of the calf in patients with chronic diseases of lower limb veins (C3EpAsPr according to the CEAP classification).	Flavonoids	36-45	biogenesis of lysosomal organelles complex 1 subunit 2	Homo sapiens	346-350
32208126-9	2020	CONCLUSION: This study highlights anticancer properties of the Hesperetin and induces apoptosis in CTCL cells via STAT3/Notch1/NFkappaB mediated signaling pathway, suggesting that further development of this novel class of flavonoid may contribute to new drug discovery for certain hematolymphoid malignancies.	Flavonoids	223-232	nuclear factor kappa B subunit 1	Homo sapiens	127-135
31648651-9	2020	RESULTS: The study revealed the potential molecular mechanisms of phenolic acids and flavonoids, which include the induction of apoptosis, inhibition of cell proliferation, cell-cycle arrest, induction of Poly ADP ribose polymerase cleavage, downregulation of Matrix metalloproteinases-2 and Matrix metalloproteinases-9 activities, decreased levels of B-cell lymphoma-2, etc.	Flavonoids	85-95	poly(ADP-ribose) polymerase 1	Homo sapiens	205-231
32115512-3	2020	In this study, we reported that kaempferol, a classic flavonoid, exhibited strong and widely inhibitory effect on the expression of fibrosis related genes in transforming growth factor beta 1 (TGF-beta1) treated NRK-52E cells.	Flavonoids	54-63	transforming growth factor, beta 1	Rattus norvegicus	158-191
32115512-3	2020	In this study, we reported that kaempferol, a classic flavonoid, exhibited strong and widely inhibitory effect on the expression of fibrosis related genes in transforming growth factor beta 1 (TGF-beta1) treated NRK-52E cells.	Flavonoids	54-63	transforming growth factor, beta 1	Rattus norvegicus	193-202
31864905-1	2020	In high fat diet-induced obese mice, the flavonoid derivative of tiliroside, Fla-CN, has antihyperglycemic effects, can improve insulin sensitivity, ameliorate metabolic lipid disorders, and benefits certain disorders characterized by insulin resistance.	Flavonoids	41-50	insulin	Homo sapiens	235-242
31785856-9	2020	Apoptosis induction triggered by this flavonoid was blocked by overexpression of the anti-apoptotic protein Bcl-2.	Flavonoids	38-47	BCL2 apoptosis regulator	Homo sapiens	108-113
31864905-1	2020	In high fat diet-induced obese mice, the flavonoid derivative of tiliroside, Fla-CN, has antihyperglycemic effects, can improve insulin sensitivity, ameliorate metabolic lipid disorders, and benefits certain disorders characterized by insulin resistance.	Flavonoids	41-50	insulin	Homo sapiens	128-135
31353930-1	2020	Trans-resveratrol (TR) is the biological active isomer of resveratrol and the one responsible for therapeutic effects; both molecules are non-flavonoid phenolics of the stilbenes class found mainly in berries and red grapes.	Flavonoids	142-151	coagulation factor II thrombin receptor	Homo sapiens	19-21
31017233-9	2020	Preliminary phytochemical screening showed that the Sc-Hex and the Sc-CHCl3 were positive for the presence of flavonoids, anthracene derivatives, quinones, triterpenes and steroids.	Flavonoids	110-120	hematopoietically expressed homeobox	Mus musculus	55-58
32268861-8	2020	RESULTS: Since, the inflammatory response is initiated by numerous signaling molecules like, NFkB, MAPK, arachidoic acid pathways and their encountering function can be done with activation of Nrf2 pathway, a promising approach to inhibit/prevent chronic inflammatory diseases by flavonoids.	Flavonoids	280-290	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
32664838-5	2020	The results of carrier inhibition experiments and transport kinetics indicated that the absorption mechanism of six flavonoids were energy-dependent monocarboxylate transporter (MCT)-mediated active transport.	Flavonoids	116-126	solute carrier family 16 member 1	Homo sapiens	149-176
32664838-5	2020	The results of carrier inhibition experiments and transport kinetics indicated that the absorption mechanism of six flavonoids were energy-dependent monocarboxylate transporter (MCT)-mediated active transport.	Flavonoids	116-126	solute carrier family 16 member 1	Homo sapiens	178-181
32664838-6	2020	In particular, para-cellular pathway also participated in the transport of IV, ST, IVG and S. Furthermore, the efflux process of six flavonoids was mediated by Pglycoprotein (P-gp) and multidrug resistance protein (MRP), which may result in a decrease of bioavailability.	Flavonoids	133-143	ATP binding cassette subfamily C member 1	Homo sapiens	185-213
32664838-6	2020	In particular, para-cellular pathway also participated in the transport of IV, ST, IVG and S. Furthermore, the efflux process of six flavonoids was mediated by Pglycoprotein (P-gp) and multidrug resistance protein (MRP), which may result in a decrease of bioavailability.	Flavonoids	133-143	ATP binding cassette subfamily C member 1	Homo sapiens	215-218
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Flavonoids	114-124	peroxisome proliferator activated receptor alpha	Homo sapiens	14-24
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Flavonoids	114-124	sirtuin 3	Homo sapiens	26-33
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Flavonoids	114-124	nuclear receptor subfamily 1 group H member 4	Homo sapiens	39-42
30638035-0	2020	The inhibitory effects of flavonoids on alpha-amylase and alpha-glucosidase.	Flavonoids	26-36	sucrase-isomaltase	Homo sapiens	58-75
30638035-1	2020	The objective of this review is to summarize knowledge on the inhibitory effects (IEs) of flavonoids on alpha-amylase (alphaA) and alpha-glucosidase (alphaG) relevant to the search of substitutes of acarbose (Aca).	Flavonoids	90-100	sucrase-isomaltase	Homo sapiens	131-148
32851955-7	2020	Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products and inhibition of the the alpha-glucosidase enzyme.	Flavonoids	10-20	sucrase-isomaltase	Homo sapiens	287-304
32400338-12	2020	CONCLUSION: These findings give new insights about the effect of HEL reducing IKK/NF-kappaB proinflammatory pathway, likely explained by the number of flavonoid contained in the extract.	Flavonoids	151-160	nuclear factor kappa B subunit 1	Homo sapiens	82-91
32648841-0	2020	Activation of caspase-3 by terpenoids and flavonoids in different types of cancer cells.	Flavonoids	42-52	caspase 3	Homo sapiens	14-23
32648841-3	2020	METHODS: We have examined the efficacy of two different sets of natural products (terpenoids and flavonoids) towards caspase-3 activity adopting in silico, cell-free and cell-based activity and real-time gene expression analysis.	Flavonoids	97-107	caspase 3	Homo sapiens	117-126
32957868-10	2020	The third one reports the efficacy of two different sets of natural products (terpenoids and flavonoids) towards caspase-3 activity.	Flavonoids	93-103	caspase 3	Homo sapiens	113-122
31218550-3	2020	We previously showed that naringenin, a citrus flavonoid, suppressed macrophage infiltration into adipose tissue by inhibiting monocyte chemoattractant protein-1 (MCP-1) expression in the progression phase to high-fat diet (HFD)-induced obesity.	Flavonoids	47-56	chemokine (C-C motif) ligand 2	Mus musculus	163-168
31441682-8	2020	Our results showed the inhibitory effect of isolated black bean flavonoid kaempferol-3-O-glycoside on cancer biomarkers: miR31 and miR92a; based on our results, this flavonoid may have interesting nutritional, therapeutic, and/or prophylactic applications to combat colon cancer.	Flavonoids	64-73	brain expressed associated with NEDD4 1	Homo sapiens	59-63
31441682-8	2020	Our results showed the inhibitory effect of isolated black bean flavonoid kaempferol-3-O-glycoside on cancer biomarkers: miR31 and miR92a; based on our results, this flavonoid may have interesting nutritional, therapeutic, and/or prophylactic applications to combat colon cancer.	Flavonoids	64-73	microRNA 31	Homo sapiens	121-126
31441682-8	2020	Our results showed the inhibitory effect of isolated black bean flavonoid kaempferol-3-O-glycoside on cancer biomarkers: miR31 and miR92a; based on our results, this flavonoid may have interesting nutritional, therapeutic, and/or prophylactic applications to combat colon cancer.	Flavonoids	166-175	brain expressed associated with NEDD4 1	Homo sapiens	59-63
31669347-0	2020	Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3beta-modulated mitochondrial binding of HKII.	Flavonoids	0-9	glycogen synthase kinase 3 beta	Homo sapiens	90-99
31669347-0	2020	Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3beta-modulated mitochondrial binding of HKII.	Flavonoids	0-9	hexokinase 2	Homo sapiens	135-139
32277647-0	2020	Phloretin flavonoid exhibits selective antiproliferative activity in doxorubicin-resistant gastric cancer cells by inducing autophagy, inhibiting cell migration and invasion, cell cycle arrest and targeting ERK1/2 MAP pathway.	Flavonoids	10-19	mitogen-activated protein kinase 3	Homo sapiens	207-213
31441682-8	2020	Our results showed the inhibitory effect of isolated black bean flavonoid kaempferol-3-O-glycoside on cancer biomarkers: miR31 and miR92a; based on our results, this flavonoid may have interesting nutritional, therapeutic, and/or prophylactic applications to combat colon cancer.	Flavonoids	166-175	microRNA 31	Homo sapiens	121-126
31888492-8	2019	CONCLUSION: Our study concluded that the citrus Cs-UGT78D3 gene contributes to proanthocyanidins accumulation in seed coats and confers tolerance to high light stress by accumulating the total anthocyanin and flavonoid contents with better antioxidant potential (due to photoprotective activity of anthocyanin) in the transgenic Arabidopsis.	Flavonoids	209-218	UDP-glucosyl transferase 78D3	Arabidopsis thaliana	51-58
32087851-9	2020	Sensitivity to Top2 inhibition correlated with a significant reduction of bioflavonoid-induced MLL-AF9 translocations.	Flavonoids	74-86	lysine methyltransferase 2A	Homo sapiens	95-98
32087851-9	2020	Sensitivity to Top2 inhibition correlated with a significant reduction of bioflavonoid-induced MLL-AF9 translocations.	Flavonoids	74-86	MLLT3 super elongation complex subunit	Homo sapiens	99-102
31618621-13	2019	The flavonoid also preserved NF-kappaB, IL-1beta, IL-10, TGF-beta, CTGF, Col-I, MMP-13 and Smad7 protein levels.	Flavonoids	4-13	interleukin 1 beta	Rattus norvegicus	40-48
31878879-6	2019	Coordinated transcriptional changes in the light signaling components CRY2 and HY5/HYHs, transcription regulator MYBA1, and enzymes LAR, ANR, UFGT and FLS4, coincided well with light-responsive biosynthesis of the corresponding flavonoids.	Flavonoids	228-238	cryptochrome circadian regulator 2	Homo sapiens	70-74
31782497-0	2019	Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycaemia.	Flavonoids	4-28	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	62-66
31697467-0	2019	The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.	Flavonoids	12-21	sodium channel, voltage-gated, type X, alpha	Mus musculus	73-79
31847879-6	2019	METHOD: In this study, we screened a small library and found that a flavonoid compound (ZGM1) promoted the aggregation of beta-amyloid (Abeta).	Flavonoids	68-77	amyloid beta (A4) precursor protein	Mus musculus	136-141
31618621-13	2019	The flavonoid also preserved NF-kappaB, IL-1beta, IL-10, TGF-beta, CTGF, Col-I, MMP-13 and Smad7 protein levels.	Flavonoids	4-13	interleukin 10	Rattus norvegicus	50-55
31618621-13	2019	The flavonoid also preserved NF-kappaB, IL-1beta, IL-10, TGF-beta, CTGF, Col-I, MMP-13 and Smad7 protein levels.	Flavonoids	4-13	cellular communication network factor 2	Rattus norvegicus	67-71
31618621-13	2019	The flavonoid also preserved NF-kappaB, IL-1beta, IL-10, TGF-beta, CTGF, Col-I, MMP-13 and Smad7 protein levels.	Flavonoids	4-13	SMAD family member 7	Rattus norvegicus	91-96
31915502-0	2019	Flavonoids from Apios americana Medikus Leaves Protect RAW264.7 Cells against Inflammation via Inhibition of MAPKs, Akt-mTOR Pathways, and Nfr2 Activation.	Flavonoids	0-10	mechanistic target of rapamycin kinase	Mus musculus	120-124
31915502-0	2019	Flavonoids from Apios americana Medikus Leaves Protect RAW264.7 Cells against Inflammation via Inhibition of MAPKs, Akt-mTOR Pathways, and Nfr2 Activation.	Flavonoids	0-10	thymoma viral proto-oncogene 1	Mus musculus	116-119
31817828-2	2019	Many natural compounds, such as flavonoids, have been described as Wnt/beta-catenin inhibitors and consequently modulate important biological processes like inflammation, redox balance, cancer promotion and progress, as well as cancer cell death.	Flavonoids	32-42	catenin beta 1	Homo sapiens	71-83
31842341-1	2019	Flavonoids have been shown to modulate GLP-1 in obesity.	Flavonoids	0-10	glucagon	Rattus norvegicus	39-44
31393601-13	2019	These flavonoids with promising plasmin inhibitory potential could be used in new dairy formulations leading to controlled undesired consequences of plasmin activity.	Flavonoids	6-16	plasminogen	Homo sapiens	32-39
31817162-1	2019	Chalcone isomerase (CHI) is a key component of phenylalanine metabolism that can produce a variety of flavonoids.	Flavonoids	102-112	chalcone--flavanone isomerase	Gossypium hirsutum	0-18
31817162-1	2019	Chalcone isomerase (CHI) is a key component of phenylalanine metabolism that can produce a variety of flavonoids.	Flavonoids	102-112	chalcone--flavanone isomerase	Gossypium hirsutum	20-23
31560953-3	2019	Here, we found that GL-V9, a newly synthesized flavonoid compound, had a potent to inhibit the activation of AKT1 and induce the cell apoptosis in T-cell malignancies including cell lines and primary lymphoblastic leukemia.	Flavonoids	47-56	thymoma viral proto-oncogene 1	Mus musculus	109-113
30724629-0	2019	Evaluation of a flavonoids library for inhibition of pancreatic alpha-amylase towards a structure-activity relationship.	Flavonoids	16-26	amylase alpha 2A	Homo sapiens	53-77
31804581-8	2019	Enhanced levels of hydroxycinnamic acid amides, typical phytoalexins of potato, in StSERK3A/B-RNAi plants are accompanied by significantly decreased levels of flavonoids and steroidal glycoalkaloids.	Flavonoids	159-169	BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like	Solanum tuberosum	83-91
31639084-8	2019	The dominant enzyme responsible for the observed metabolic reactions is CYP1A2, whereas other human liver cytochromes P450, namely, CYP2C19, CYP2D6, CYP2E1 and CYP3A4, contribute to flavonoid metabolism to a lesser degree.	Flavonoids	182-191	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	72-78
31639084-8	2019	The dominant enzyme responsible for the observed metabolic reactions is CYP1A2, whereas other human liver cytochromes P450, namely, CYP2C19, CYP2D6, CYP2E1 and CYP3A4, contribute to flavonoid metabolism to a lesser degree.	Flavonoids	182-191	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	132-139
31639084-8	2019	The dominant enzyme responsible for the observed metabolic reactions is CYP1A2, whereas other human liver cytochromes P450, namely, CYP2C19, CYP2D6, CYP2E1 and CYP3A4, contribute to flavonoid metabolism to a lesser degree.	Flavonoids	182-191	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	141-147
31639084-8	2019	The dominant enzyme responsible for the observed metabolic reactions is CYP1A2, whereas other human liver cytochromes P450, namely, CYP2C19, CYP2D6, CYP2E1 and CYP3A4, contribute to flavonoid metabolism to a lesser degree.	Flavonoids	182-191	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	149-155
31639084-8	2019	The dominant enzyme responsible for the observed metabolic reactions is CYP1A2, whereas other human liver cytochromes P450, namely, CYP2C19, CYP2D6, CYP2E1 and CYP3A4, contribute to flavonoid metabolism to a lesser degree.	Flavonoids	182-191	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	160-166
31393601-13	2019	These flavonoids with promising plasmin inhibitory potential could be used in new dairy formulations leading to controlled undesired consequences of plasmin activity.	Flavonoids	6-16	plasminogen	Homo sapiens	149-156
31515296-2	2019	Morin, a kind of flavonoid, exhibits a significant anticancer activity by suppressing the PI3K/AKT signaling pathway.	Flavonoids	17-26	AKT serine/threonine kinase 1	Homo sapiens	95-98
31401916-0	2019	The regulatory effect of flavonoids extracted from Abutilon theophrasti leaves on gene expression in LPS-induced ALI mice via the NF-kappaB and MAPK signaling pathways.	Flavonoids	25-35	mitogen-activated protein kinase 1	Mus musculus	144-148
31493543-0	2019	Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship.	Flavonoids	36-46	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	50-82
31068038-0	2019	Methanol extract of Muntingia calabura leaves attenuates CCl4-induced liver injury: possible synergistic action of flavonoids and volatile bioactive compounds on endogenous defence system.	Flavonoids	115-125	C-C motif chemokine ligand 4	Rattus norvegicus	57-61
31493543-0	2019	Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship.	Flavonoids	36-46	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	84-88
31493543-6	2019	Molecular docking analysis elucidated the inhibition of flavonoids on BCRP might be associated with Pi-Pi stacked interactions and/or potential Pi-Alkyl interactions, but not conventional hydrogen bonds.	Flavonoids	56-66	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	70-74
31493543-7	2019	The pharmacophore model indicated the aromatic ring B, hydrophobic groups and hydrogen bond acceptors may play critical role in the potency of flavonoids inhibition on BCRP.	Flavonoids	143-153	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	168-172
31493543-1	2019	Flavonoids are a group of polyphenols ubiquitously present in vegetables, fruits and herbal products, despite various known pharmacological activities, few researches have been done about the interaction of flavonoids with breast cancer resistance protein (BCRP).	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	223-255
31493543-1	2019	Flavonoids are a group of polyphenols ubiquitously present in vegetables, fruits and herbal products, despite various known pharmacological activities, few researches have been done about the interaction of flavonoids with breast cancer resistance protein (BCRP).	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	257-261
31493543-1	2019	Flavonoids are a group of polyphenols ubiquitously present in vegetables, fruits and herbal products, despite various known pharmacological activities, few researches have been done about the interaction of flavonoids with breast cancer resistance protein (BCRP).	Flavonoids	207-217	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	223-255
31493543-1	2019	Flavonoids are a group of polyphenols ubiquitously present in vegetables, fruits and herbal products, despite various known pharmacological activities, few researches have been done about the interaction of flavonoids with breast cancer resistance protein (BCRP).	Flavonoids	207-217	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	257-261
31493543-2	2019	The present study was designed to investigate the inhibitory effects of 99 flavonoids on BCRP in vitro and in vivo and to clarify structure-activity relationships of flavonoids with BCRP.	Flavonoids	75-85	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	89-93
31493543-2	2019	The present study was designed to investigate the inhibitory effects of 99 flavonoids on BCRP in vitro and in vivo and to clarify structure-activity relationships of flavonoids with BCRP.	Flavonoids	166-176	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	182-186
32237356-14	2019	Flavonoid components in AR could decrease the expression of X-box binding protein 1( XBP1),inositol-requiring enzyme( IRE1) and glucose regulated protein 78 k D( GRP78),and increase the expression of C/EBP homologous protein( CHOP),and the high-dose group is better,suggesting that the anti-lung cancer effect of flavonoid components in AR is related to the regulation of XBP1 mediated ERs.	Flavonoids	0-9	X-box binding protein 1	Mus musculus	60-83
32237356-14	2019	Flavonoid components in AR could decrease the expression of X-box binding protein 1( XBP1),inositol-requiring enzyme( IRE1) and glucose regulated protein 78 k D( GRP78),and increase the expression of C/EBP homologous protein( CHOP),and the high-dose group is better,suggesting that the anti-lung cancer effect of flavonoid components in AR is related to the regulation of XBP1 mediated ERs.	Flavonoids	0-9	X-box binding protein 1	Mus musculus	85-89
32237356-14	2019	Flavonoid components in AR could decrease the expression of X-box binding protein 1( XBP1),inositol-requiring enzyme( IRE1) and glucose regulated protein 78 k D( GRP78),and increase the expression of C/EBP homologous protein( CHOP),and the high-dose group is better,suggesting that the anti-lung cancer effect of flavonoid components in AR is related to the regulation of XBP1 mediated ERs.	Flavonoids	0-9	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	118-122
32237356-14	2019	Flavonoid components in AR could decrease the expression of X-box binding protein 1( XBP1),inositol-requiring enzyme( IRE1) and glucose regulated protein 78 k D( GRP78),and increase the expression of C/EBP homologous protein( CHOP),and the high-dose group is better,suggesting that the anti-lung cancer effect of flavonoid components in AR is related to the regulation of XBP1 mediated ERs.	Flavonoids	0-9	heat shock protein 5	Mus musculus	162-167
32237356-14	2019	Flavonoid components in AR could decrease the expression of X-box binding protein 1( XBP1),inositol-requiring enzyme( IRE1) and glucose regulated protein 78 k D( GRP78),and increase the expression of C/EBP homologous protein( CHOP),and the high-dose group is better,suggesting that the anti-lung cancer effect of flavonoid components in AR is related to the regulation of XBP1 mediated ERs.	Flavonoids	0-9	DNA-damage inducible transcript 3	Mus musculus	226-230
32237356-14	2019	Flavonoid components in AR could decrease the expression of X-box binding protein 1( XBP1),inositol-requiring enzyme( IRE1) and glucose regulated protein 78 k D( GRP78),and increase the expression of C/EBP homologous protein( CHOP),and the high-dose group is better,suggesting that the anti-lung cancer effect of flavonoid components in AR is related to the regulation of XBP1 mediated ERs.	Flavonoids	0-9	X-box binding protein 1	Mus musculus	372-376
31621310-1	2019	Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects.	Flavonoids	46-56	aryl hydrocarbon receptor	Homo sapiens	96-121
31783532-5	2019	Herein, we summarize recent published studies on the regulation of tumor PD-L1 by flavonoids and grape polyphenols.	Flavonoids	82-92	CD274 molecule	Homo sapiens	73-78
31783532-9	2019	The modulation of tumor PD-L1 by flavonoids or polyphenols is proposed to improve the response to PLB in low PD-L1 tumors.	Flavonoids	33-43	CD274 molecule	Homo sapiens	24-29
31783532-9	2019	The modulation of tumor PD-L1 by flavonoids or polyphenols is proposed to improve the response to PLB in low PD-L1 tumors.	Flavonoids	33-43	phospholamban	Homo sapiens	98-101
31783532-9	2019	The modulation of tumor PD-L1 by flavonoids or polyphenols is proposed to improve the response to PLB in low PD-L1 tumors.	Flavonoids	33-43	CD274 molecule	Homo sapiens	109-114
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	Flavonoids	55-64	complement C2	Homo sapiens	174-177
31621310-1	2019	Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects.	Flavonoids	46-56	aryl hydrocarbon receptor	Homo sapiens	123-126
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	Flavonoids	55-64	complement C3	Homo sapiens	192-195
31621310-4	2019	The structure-activity relationships for the flavonoids were complex and both response and cell context specific; however, there was significant variability in the AhR activities of the isomeric substituted isoflavones and flavones.	Flavonoids	45-55	aryl hydrocarbon receptor	Homo sapiens	164-167
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	Flavonoids	55-64	aryl hydrocarbon receptor	Homo sapiens	313-316
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	Flavonoids	55-64	aryl hydrocarbon receptor	Homo sapiens	88-91
31731716-0	2019	Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling.	Flavonoids	8-27	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Danio rerio	116-119
31731716-0	2019	Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling.	Flavonoids	8-27	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	120-125
31731716-6	2019	Flavonoids Lu and Qu reduce protein levels of p-Src, p-Stat3 and S100A7 in A431-III cells.	Flavonoids	0-10	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Danio rerio	48-51
31731716-6	2019	Flavonoids Lu and Qu reduce protein levels of p-Src, p-Stat3 and S100A7 in A431-III cells.	Flavonoids	0-10	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	55-60
31694152-0	2019	Acute Ingestion of a Mixed Flavonoid and Caffeine Supplement Increases Energy Expenditure and Fat Oxidation in Adult Women: A Randomized, Crossover Clinical Trial.	Flavonoids	27-36	FAT atypical cadherin 1	Homo sapiens	94-97
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Flavonoids	2-11	ATM serine/threonine kinase	Homo sapiens	76-79
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Flavonoids	2-11	choline kinase alpha	Homo sapiens	80-83
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Flavonoids	2-11	tumor protein p53	Homo sapiens	84-87
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Flavonoids	2-11	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	172-176
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Flavonoids	2-11	BCL2 like 1	Homo sapiens	249-255
31489680-10	2019	Qualitative characterisation of APM indicated existence of alkaloids, terpenoids, coumarins, cardiac glycosides, phenols, flavonoids, saponins, tannins and sterols.	Flavonoids	122-132	alanyl aminopeptidase, membrane	Rattus norvegicus	32-35
31659097-4	2019	Previously, we demonstrated that in the MDA-MB-231 TNBC cell line, TNFalpha evoked a rise in immune signaling proteins: CCL2, granulocyte macrophage colony-stimulating factor, interleukin (IL)1alpha, IL6 and inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKepsilon) all of which were attenuated by apigenin, a dietary flavonoid found in chamomile and parsley.	Flavonoids	333-342	tumor necrosis factor	Homo sapiens	67-75
32104488-0	2019	Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models.	Flavonoids	32-41	ATP binding cassette subfamily C member 2	Rattus norvegicus	18-22
31437460-1	2019	BACKGROUND: Flavonoids form a diverse class of naturally occurring polyphenols ascribed various biological activities, including inhibition of amyloid beta (Abeta) fibrillisation and neurotoxicity of relevance to Alzheimer"s disease.	Flavonoids	12-22	amyloid beta precursor protein	Rattus norvegicus	157-162
31501221-0	2019	Direct measurement of kinetic parameters of ABCG2-dependent transport of natural flavonoids using a fluorogenic substrate.	Flavonoids	81-91	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-49
30934143-3	2019	Although naturally occurring flavonoids are the most studied ones, semi-synthetic or synthetic flavonoids have proven to have great potential, inhibiting and even killing microbes at concentrations below 1 mug ml-1 .	Flavonoids	95-105	interleukin 17F	Homo sapiens	210-214
31004355-4	2019	Here, we show that Myricetin, a flavonoid, can eliminate various abnormal proteins from the cellular environment via modulating endogenous levels of Hsp70 chaperone and quality control (QC)-E3 ubiquitin ligase E6-AP.	Flavonoids	32-41	ubiquitin protein ligase E3A	Homo sapiens	210-215
31683873-4	2019	Phylogenetic analysis indicated that NtMYB3 belongs to the AtMYB4-like clade, which includes repressor MYBs involved in the regulation of flavonoid biosynthesis.	Flavonoids	138-147	myb domain protein 4	Arabidopsis thaliana	59-65
31659812-7	2019	Collectively, EAE-FPN with phenolic/flavonoid content showed excellent antioxidant and anti-inflammatory properties via modulating NF-kappaB signaling pathway.	Flavonoids	36-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-140
31501221-2	2019	A central determinant of absorption and distribution of flavonoids in the human body is the ABC transporter ABCG2, expressed in gut epithelium and in other barrier tissues.	Flavonoids	56-66	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	108-113
31501221-4	2019	We present a novel method which allows the direct measurement of kinetic constants for ABCG2-mediated cellular efflux of natural flavonoids thanks to the application of fluorogenic 2-aminoethyl diphenylborinate (APB) which reacts with intracellular flavonoids forming a fluorescent, non-membrane-permeable conjugate, thus making it possible to measure the intracellular substrate concentration throughout the experiment.	Flavonoids	129-139	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	87-92
31501221-4	2019	We present a novel method which allows the direct measurement of kinetic constants for ABCG2-mediated cellular efflux of natural flavonoids thanks to the application of fluorogenic 2-aminoethyl diphenylborinate (APB) which reacts with intracellular flavonoids forming a fluorescent, non-membrane-permeable conjugate, thus making it possible to measure the intracellular substrate concentration throughout the experiment.	Flavonoids	249-259	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	87-92
31356770-3	2019	Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis.	Flavonoids	33-42	thymoma viral proto-oncogene 1	Mus musculus	83-86
31545438-11	2019	The present data suggested that SZS flavonoids could protect myocardial cells against acute heart ischemia-reperfusion, probably via the inhibition of GSK3beta, which increased autophagy and the activity of the PGC-1alpha/Nrf2/HO-1 pathway.	Flavonoids	36-46	glycogen synthase kinase 3 alpha	Rattus norvegicus	151-159
31545438-11	2019	The present data suggested that SZS flavonoids could protect myocardial cells against acute heart ischemia-reperfusion, probably via the inhibition of GSK3beta, which increased autophagy and the activity of the PGC-1alpha/Nrf2/HO-1 pathway.	Flavonoids	36-46	PPARG coactivator 1 alpha	Rattus norvegicus	211-221
31545438-11	2019	The present data suggested that SZS flavonoids could protect myocardial cells against acute heart ischemia-reperfusion, probably via the inhibition of GSK3beta, which increased autophagy and the activity of the PGC-1alpha/Nrf2/HO-1 pathway.	Flavonoids	36-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	222-226
32024626-6	2019	The isolated flavonoids reduced considerably the serum ALP, SGPT and SGOT in rats intoxicated with streptozotocin.	Flavonoids	13-23	PDZ and LIM domain 3	Rattus norvegicus	55-58
31410984-2	2019	Flavonoid-rich concentrated extract from Prunus mahaleb (mahaleb concentrated fruit extract; MCFE) may act on oxido-reductive homeostasis and hepatic lipid metabolism via Nrf2.	Flavonoids	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	171-175
31356770-3	2019	Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis.	Flavonoids	33-42	transformation related protein 53, pseudogene	Mus musculus	91-94
31356770-3	2019	Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis.	Flavonoids	33-42	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	95-98
31749703-0	2019	Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NFkappaB) Signaling in Cardiovascular Diseases: A Mini Review.	Flavonoids	0-10	nuclear factor kappa B subunit 1	Homo sapiens	57-79
31749703-0	2019	Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NFkappaB) Signaling in Cardiovascular Diseases: A Mini Review.	Flavonoids	0-10	nuclear factor kappa B subunit 1	Homo sapiens	81-89
31749703-6	2019	As NFkappaB inhibitors, these flavonoids may modulate the expression of pro-inflammatory genes leading to the attenuation of the inflammatory responses underlying various cardiovascular pathology.	Flavonoids	30-40	nuclear factor kappa B subunit 1	Homo sapiens	3-11
31749703-7	2019	This review presents an update on the anti-inflammatory actions of flavonoids via inhibition of NFkappaB mechanism supporting the therapeutic potential of these natural compounds in various CVDs.	Flavonoids	67-77	nuclear factor kappa B subunit 1	Homo sapiens	96-104
31658678-0	2019	Genome-Wide Identification of Direct Targets of the TTG1-bHLH-MYB Complex in Regulating Trichome Formation and Flavonoid Accumulation in Arabidopsis Thaliana.	Flavonoids	111-120	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	52-56
31681342-5	2019	Pigment production was the result of an up-regulation of the expression level of key genes of the flavonoid biosynthetic pathway, such as NtCHS, NtCHI, NtF3H, NtDFR, NtANS, and NtUFGT, as well as of the proanthocyanidin biosynthetic pathway such as NtLAR.	Flavonoids	98-107	flavanone 3-hydroxylase	Nicotiana tabacum	152-157
31614687-7	2019	The expressions of crucial genes (bAS and CHS), key enzymes of triterpenoid and flavonoid synthesis, were also tested by qRT-PCR.	Flavonoids	80-89	lysosomal trafficking regulator	Homo sapiens	42-45
31655554-0	2019	Tomato glycosyltransferase Twi1 plays a role in flavonoid glycosylation and defence against virus.	Flavonoids	48-57	scopoletin glucosyltransferase	Solanum lycopersicum	27-31
31655554-5	2019	RESULTS: Here we provide evidence that the previously described tomato wound and pathogen-induced glycosyltransferase Twi1 displays in vitro activity toward the coumarins scopoletin, umbelliferone and esculetin, and the flavonoids quercetin and kaempferol, by uncovering a new role of this gene in plant glycosylation.	Flavonoids	220-230	scopoletin glucosyltransferase	Solanum lycopersicum	118-122
31635144-9	2019	The suitable conditions for this enzyme activity were pH 7.5, 10 mM of magnesium ions, and 30  C. In addition, BtGT_16345 showed glycosylation activity toward seven flavonoids (apigenein, quercetein, naringenein, resveratrol, genistein, daidzein, and 8-hydroxydaidzein) and two triterpenoids (GAA and antcin K).	Flavonoids	165-175	alpha glucosidase	Danio rerio	293-296
31658678-1	2019	Extensive studies have shown that the MBW complex consisting of three kinds of regulatory proteins, MYB and basic helix-loop-helix (bHLH) transcription factors and a WD40 repeat protein, TRANSPARENT TESTA GLABRA1 (TTG1), acts in concert to promote trichome formation and flavonoid accumulation in Arabidopsis thaliana.	Flavonoids	271-280	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	187-212
31658678-1	2019	Extensive studies have shown that the MBW complex consisting of three kinds of regulatory proteins, MYB and basic helix-loop-helix (bHLH) transcription factors and a WD40 repeat protein, TRANSPARENT TESTA GLABRA1 (TTG1), acts in concert to promote trichome formation and flavonoid accumulation in Arabidopsis thaliana.	Flavonoids	271-280	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	214-218
31658678-4	2019	In the present study, we found, through RNA sequencing and quantitative real-time PCR analysis, that a great number of regulatory and structural genes involved in both trichome formation and flavonoid accumulation are significantly downregulated in the young shoots and expanding true leaves of ttg1-13 plants.	Flavonoids	191-200	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	295-299
31658678-5	2019	Post-translational activation of a TTG1-glucocorticoid receptor fusion protein and chromatin immunoprecipitation assays demonstrated that these downregulated genes are directly or indirectly targeted by the TTG1-dependent MBW complex in vivo during trichome formation and flavonoid accumulation.	Flavonoids	272-281	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	35-39
31658678-5	2019	Post-translational activation of a TTG1-glucocorticoid receptor fusion protein and chromatin immunoprecipitation assays demonstrated that these downregulated genes are directly or indirectly targeted by the TTG1-dependent MBW complex in vivo during trichome formation and flavonoid accumulation.	Flavonoids	272-281	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	207-211
31658678-6	2019	These findings further extend our understanding of the role of TTG1-dependent MBW complex in the regulation of trichome formation and flavonoid accumulation in A. thaliana.	Flavonoids	134-143	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	63-67
31100755-9	2019	The accumulation of flavonoids was also consistent with this interaction between CRYs and UVR8.	Flavonoids	20-30	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	90-94
31601032-2	2019	In the network, it has been proposed that the MYB-bHLH-WD40 (MBW) activator complexes formed by an R2R3 MYB transcription factor, a bHLH transcription factor and the WD40-repeat protein TRANSPARENT TESTA GLABRA1 (TTG1) regulate the expression of downstream genes required for cell fate determination, flavonoid or mucilage biosynthesis, respectively.	Flavonoids	301-310	myb domain protein 0	Arabidopsis thaliana	204-211
31601032-2	2019	In the network, it has been proposed that the MYB-bHLH-WD40 (MBW) activator complexes formed by an R2R3 MYB transcription factor, a bHLH transcription factor and the WD40-repeat protein TRANSPARENT TESTA GLABRA1 (TTG1) regulate the expression of downstream genes required for cell fate determination, flavonoid or mucilage biosynthesis, respectively.	Flavonoids	301-310	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	213-217
31649700-4	2019	Moreover, the expression of key genes in the flavonoid synthesis pathway was repressed in CsTRY overexpressing plants, which resulted in the decrease of several important flavonoid secondary metabolites.	Flavonoids	45-54	transcription factor TRY	Cucumis sativus	90-95
31649700-4	2019	Moreover, the expression of key genes in the flavonoid synthesis pathway was repressed in CsTRY overexpressing plants, which resulted in the decrease of several important flavonoid secondary metabolites.	Flavonoids	171-180	transcription factor TRY	Cucumis sativus	90-95
31649700-5	2019	In addition, CsTRY could interact with the AN1 homologous gene CsAN1 (Csa7G044190) in cucumber, which further confirmed that CsTRY not only regulates the development of fruit spines, but also functions in the synthesis of flavonoids, acting as the repressor of anthocyanin synthesis.	Flavonoids	222-232	transcription factor TRY	Cucumis sativus	13-18
31649700-5	2019	In addition, CsTRY could interact with the AN1 homologous gene CsAN1 (Csa7G044190) in cucumber, which further confirmed that CsTRY not only regulates the development of fruit spines, but also functions in the synthesis of flavonoids, acting as the repressor of anthocyanin synthesis.	Flavonoids	222-232	transcription factor TRY	Cucumis sativus	125-130
31545266-13	2019	These findings firstly illustrated the behavior of epimedin C and icariin from Epimedii herba on LPS-induced osteoblasts and the regulatory property on the expression of key genes and proteins of the BMP-2/Runx2 signalling pathway, which might be helpful for better understanding flavonoids" mechanism to enhance bone repair and improving their future application.	Flavonoids	280-290	bone morphogenetic protein 2	Homo sapiens	200-205
31309484-7	2019	Flavonoids also reduce the risk of atherosclerosis and atherothrombotic disease by inhibiting excessive tissue factor (TF) availability in the endothelium.	Flavonoids	0-10	coagulation factor III, tissue factor	Homo sapiens	104-117
31309484-7	2019	Flavonoids also reduce the risk of atherosclerosis and atherothrombotic disease by inhibiting excessive tissue factor (TF) availability in the endothelium.	Flavonoids	0-10	coagulation factor III, tissue factor	Homo sapiens	119-121
31590760-3	2019	Quercetin is a flavonoid that is abundant in apples, grapes, red raspberry, and onions and has been reported to inhibit RAGE.	Flavonoids	15-24	advanced glycosylation end-product specific receptor	Homo sapiens	120-124
31359514-7	2019	The flavonoid phlorizin, which can be isolated from the bark of apple trees, has been used as lead structure due to its inhibitory activity of SGLT1 and SGLT2.	Flavonoids	4-13	solute carrier family 5 member 2	Homo sapiens	153-158
31393836-3	2019	Although several flavonoids had already demonstrated the capacity of inhibiting aromatase activity, the role of biflavonoids as aromatase inhibitors is poorly studied.	Flavonoids	17-27	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	80-89
31238104-0	2019	Flavonoids of Tripodanthus acutifolius inhibit TNF-alpha production in LPS-activated THP-1 and B16-F10 cells.	Flavonoids	0-10	tumor necrosis factor	Mus musculus	47-56
31238104-0	2019	Flavonoids of Tripodanthus acutifolius inhibit TNF-alpha production in LPS-activated THP-1 and B16-F10 cells.	Flavonoids	0-10	toll-like receptor 4	Mus musculus	71-74
31238104-0	2019	Flavonoids of Tripodanthus acutifolius inhibit TNF-alpha production in LPS-activated THP-1 and B16-F10 cells.	Flavonoids	0-10	GLI family zinc finger 2	Homo sapiens	85-90
31590321-0	2019	Consumption of Korean Foods with High Flavonoid Contents Reduces the Likelihood of Having Elevated C-Reactive Protein Levels: Data from the 2015-2017 Korea National Health and Nutrition Examination Survey.	Flavonoids	38-47	C-reactive protein	Homo sapiens	99-117
31590321-1	2019	This study was conducted to investigate associations between C-reactive protein (CRP) levels and Korean food (KF) consumption and flavonoid intake from the 2015-2017 Korea National Health and Nutrition Examination Survey.	Flavonoids	130-139	C-reactive protein	Homo sapiens	61-79
31590321-1	2019	This study was conducted to investigate associations between C-reactive protein (CRP) levels and Korean food (KF) consumption and flavonoid intake from the 2015-2017 Korea National Health and Nutrition Examination Survey.	Flavonoids	130-139	C-reactive protein	Homo sapiens	81-84
31590321-4	2019	Odds ratios (ORs) for elevated CRP levels (>3.0 mg/L) according to KF consumption rate and flavonoid intake/dietary total antioxidant capacity (TAC) (<median; >=median) were obtained by multiple logistic regression.	Flavonoids	91-100	C-reactive protein	Homo sapiens	31-34
31590321-7	2019	Thus, consuming KFs rich in flavonoid is effective for regulating CRP levels.	Flavonoids	28-37	C-reactive protein	Homo sapiens	66-69
31545278-0	2019	The renal protection of flavonoid-rich ethanolic extract from silkworm green cocoon involves in inhibiting TNF-alpha-p38 MAP kinase signalling pathway in type 2 diabetic mice.	Flavonoids	24-33	tumor necrosis factor	Mus musculus	107-116
31437792-2	2019	Previous studies have shown that baicalein and baicalin are directly cytotoxic to some tumors, here we demonstrate that in addition to direct cytotoxicity, these two flavonoids stimulate the T cell mediated immune response against tumors through reduction of PD-L1 expression in cancer cells.	Flavonoids	166-176	CD274 antigen	Mus musculus	259-264
31437792-4	2019	PD-L1 upregulation induced by interferon-gamma (IFN-gamma) was significantly inhibited by these two flavonoids in vitro.	Flavonoids	100-110	CD274 antigen	Mus musculus	0-5
31437792-4	2019	PD-L1 upregulation induced by interferon-gamma (IFN-gamma) was significantly inhibited by these two flavonoids in vitro.	Flavonoids	100-110	interferon gamma	Mus musculus	30-46
31437792-4	2019	PD-L1 upregulation induced by interferon-gamma (IFN-gamma) was significantly inhibited by these two flavonoids in vitro.	Flavonoids	100-110	interferon gamma	Mus musculus	48-57
31437792-6	2019	Further mechanistic research indicated that the IFN-gamma-induced expression and promoter activity of PD-L1 were suppressed by these two flavonoids, and these effects were mediated by STAT3 activity inhibition.	Flavonoids	137-147	interferon gamma	Mus musculus	48-57
31437792-6	2019	Further mechanistic research indicated that the IFN-gamma-induced expression and promoter activity of PD-L1 were suppressed by these two flavonoids, and these effects were mediated by STAT3 activity inhibition.	Flavonoids	137-147	CD274 antigen	Mus musculus	102-107
31437792-8	2019	Our findings provide novel insight into the anticancer effects of baicalein and baicalin through which tumor growth is inhibited by PD-L1 expression downregulation and suggest that these flavonoids have great potential for clinical treatment.	Flavonoids	187-197	CD274 antigen	Mus musculus	132-137
31465686-0	2019	Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.	Flavonoids	17-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	76-108
31465686-0	2019	Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.	Flavonoids	17-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	110-114
31465686-0	2019	Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.	Flavonoids	17-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	115-120
31465686-1	2019	The present work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective BCRP inhibitors.	Flavonoids	69-78	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	140-144
31017523-7	2019	Citrus flavonoids likely regulate lipid metabolism by modulating the expression levels of miR-122 and miR-33.	Flavonoids	7-17	microRNA 122	Homo sapiens	90-97
31461284-0	2019	Comparative Study of Dietary Flavonoids with Different Structures as alpha-Glucosidase Inhibitors and Insulin Sensitizers.	Flavonoids	29-39	sucrase-isomaltase	Homo sapiens	69-86
31461284-1	2019	This work was designed to comparatively investigate 27 dietary flavonoids that act as alpha-glucosidase inhibitors and insulin sensitizers.	Flavonoids	63-73	sucrase-isomaltase	Homo sapiens	86-103
31527518-0	2019	Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells.	Flavonoids	26-35	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	100-107
31491838-8	2019	In agreement, each flavonoid inhibited p-STAT3 in a dose-dependent manner, with estimated IC50 values in the 3.5-70 muM range.	Flavonoids	19-28	signal transducer and activator of transcription 3	Homo sapiens	41-46
31491838-9	2019	Finally, docking analysis confirmed the capacity of each flavonoid to bind in an energetically favorable configuration to IL-6Ralpha at a site predicted to interfere with ligand binding.	Flavonoids	57-66	interleukin 6 receptor	Homo sapiens	122-132
31491838-10	2019	Taken together, our findings identify IL-6Ralpha as a direct target of MH and its flavonoids, highlighting IL-6R blockade as a mechanism for the anti-tumor activity of MH, as well as a viable therapeutic target in IL-6-dependent cancers.	Flavonoids	82-92	interleukin 6 receptor	Homo sapiens	38-48
31491838-10	2019	Taken together, our findings identify IL-6Ralpha as a direct target of MH and its flavonoids, highlighting IL-6R blockade as a mechanism for the anti-tumor activity of MH, as well as a viable therapeutic target in IL-6-dependent cancers.	Flavonoids	82-92	interleukin 6 receptor	Homo sapiens	38-43
31491838-10	2019	Taken together, our findings identify IL-6Ralpha as a direct target of MH and its flavonoids, highlighting IL-6R blockade as a mechanism for the anti-tumor activity of MH, as well as a viable therapeutic target in IL-6-dependent cancers.	Flavonoids	82-92	interleukin 6	Homo sapiens	38-42
31054689-6	2019	In addition, heat shock proteins (HSPs) and flavonoid biosynthetic proteins, such as cinnamate 4-hydroxylase, chalcone isomerase, chalcone synthase, isoflavone synthase and isoflavone reductase, were also modulated in response to sodium nitroprusside treatment.	Flavonoids	44-53	eugenol synthase 1	Glycine max	130-193
31017523-0	2019	Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells.	Flavonoids	12-22	microRNA 33a	Homo sapiens	62-68
31017523-0	2019	Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells.	Flavonoids	12-22	microRNA 122	Homo sapiens	73-80
31017523-5	2019	Flavonoid compounds from citrus peel suppressed miR-122 and miR-33 expression, which were induced by oleic acid.	Flavonoids	0-9	microRNA 122	Homo sapiens	48-55
31017523-5	2019	Flavonoid compounds from citrus peel suppressed miR-122 and miR-33 expression, which were induced by oleic acid.	Flavonoids	0-9	microRNA 33a	Homo sapiens	60-66
31017523-7	2019	Citrus flavonoids likely regulate lipid metabolism by modulating the expression levels of miR-122 and miR-33.	Flavonoids	7-17	microRNA 33a	Homo sapiens	102-108
31480505-9	2019	The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-kappaB.	Flavonoids	108-118	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	248-252
31480505-9	2019	The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-kappaB.	Flavonoids	108-118	peroxisome proliferator activated receptor alpha	Homo sapiens	254-258
31150785-5	2019	Additionally, the antioxidant activity was improved, which may be attributed to the increase of total phenols and flavonoids up to 4629.21 mug GAE mL-1 and 404.99 mug RE mL-1.	Flavonoids	114-124	L1 cell adhesion molecule	Mus musculus	147-162
31150785-5	2019	Additionally, the antioxidant activity was improved, which may be attributed to the increase of total phenols and flavonoids up to 4629.21 mug GAE mL-1 and 404.99 mug RE mL-1.	Flavonoids	114-124	L1 cell adhesion molecule	Mus musculus	147-151
31469378-9	2019	The results suggest that pasta formulated with legume flours is a low glycaemic food and can be considered a suitable source of polyphenols and flavonoids in human diet.	Flavonoids	144-154	solute carrier family 45 member 1	Homo sapiens	25-30
31441917-0	2019	The dipeptidyl peptidase-4 inhibitory effect of flavonoids is hindered in protein rich environments.	Flavonoids	48-58	dipeptidyl peptidase 4	Homo sapiens	4-26
31441917-2	2019	In the present study, the inhibition of DPP-4 was evaluated for a large panel of flavonoids, important components of the human diet, using in vitro and ex vivo models.	Flavonoids	81-91	dipeptidyl peptidase 4	Homo sapiens	40-45
31441917-7	2019	This work provides a new insight into the inhibitory activity for DPP-4, based on the flavonoid scaffold.	Flavonoids	86-95	dipeptidyl peptidase 4	Homo sapiens	66-71
31441917-8	2019	Additionally, the obtained results showed that the inhibitory effect of flavonoids against DPP-4 was hindered in protein rich environments, like that occurring in blood, and indicated the need for experimental refinement in drug discovery for blood targets.	Flavonoids	72-82	dipeptidyl peptidase 4	Homo sapiens	91-96
31152156-0	2019	Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress.	Flavonoids	0-9	thioredoxin interacting protein	Mus musculus	67-72
31934188-0	2019	Hawthorne leaf flavonoids prevent oxidative stress injury of renal tissues in rats with diabetic kidney disease by regulating the p38 MAPK signaling pathway.	Flavonoids	15-25	mitogen activated protein kinase 14	Rattus norvegicus	130-133
31006447-0	2019	Structure affinity relationship and docking studies of flavonoids as substrates of multidrug-resistant associated protein 2 (MRP2) in MDCK/MRP2 cells.	Flavonoids	55-65	ATP binding cassette subfamily C member 2	Canis lupus familiaris	83-123
31006447-0	2019	Structure affinity relationship and docking studies of flavonoids as substrates of multidrug-resistant associated protein 2 (MRP2) in MDCK/MRP2 cells.	Flavonoids	55-65	ATP binding cassette subfamily C member 2	Canis lupus familiaris	125-129
31006447-0	2019	Structure affinity relationship and docking studies of flavonoids as substrates of multidrug-resistant associated protein 2 (MRP2) in MDCK/MRP2 cells.	Flavonoids	55-65	ATP binding cassette subfamily C member 2	Canis lupus familiaris	139-143
31006447-1	2019	This study was aimed to determine the relationship of flavonoid structures to their affinity for an important efflux transporter, multidrug-resistant associated protein 2 (MRP2).	Flavonoids	54-63	ATP binding cassette subfamily C member 2	Canis lupus familiaris	130-170
31006447-1	2019	This study was aimed to determine the relationship of flavonoid structures to their affinity for an important efflux transporter, multidrug-resistant associated protein 2 (MRP2).	Flavonoids	54-63	ATP binding cassette subfamily C member 2	Canis lupus familiaris	172-176
31006447-2	2019	The cellular uptake (CU) of 35 flavonoids was investigated in MRP2 overexpression MDCK/MRP2 cells.	Flavonoids	31-41	ATP binding cassette subfamily C member 2	Canis lupus familiaris	62-66
31006447-2	2019	The cellular uptake (CU) of 35 flavonoids was investigated in MRP2 overexpression MDCK/MRP2 cells.	Flavonoids	31-41	ATP binding cassette subfamily C member 2	Canis lupus familiaris	87-91
31006447-3	2019	Resulting data identified 8 flavonoids as MRP2 substrates based on their high CUMK with MK-571 in MDCK/MRP2 cells.	Flavonoids	28-38	ATP binding cassette subfamily C member 2	Canis lupus familiaris	42-46
31006447-3	2019	Resulting data identified 8 flavonoids as MRP2 substrates based on their high CUMK with MK-571 in MDCK/MRP2 cells.	Flavonoids	28-38	ATP binding cassette subfamily C member 2	Canis lupus familiaris	103-107
31152156-0	2019	Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress.	Flavonoids	0-9	NLR family, pyrin domain containing 3	Mus musculus	83-88
31894062-0	2019	Nootropic effects of synthetic flavonoid derivatives on scopolamine induced memory impairment in mice via cholinesterase inhibition and antioxidant system.	Flavonoids	31-40	butyrylcholinesterase	Mus musculus	106-120
31480528-10	2019	The flavonoids in this study were mainly reversible inhibitors of CYP1A2 and CYP2A6, while the inhibition of CYP2C8 was of mixed type (reversible and irreversible).	Flavonoids	4-14	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	66-72
31480528-10	2019	The flavonoids in this study were mainly reversible inhibitors of CYP1A2 and CYP2A6, while the inhibition of CYP2C8 was of mixed type (reversible and irreversible).	Flavonoids	4-14	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	77-83
31480528-10	2019	The flavonoids in this study were mainly reversible inhibitors of CYP1A2 and CYP2A6, while the inhibition of CYP2C8 was of mixed type (reversible and irreversible).	Flavonoids	4-14	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	109-115
31480528-0	2019	The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity.	Flavonoids	14-23	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
31480528-0	2019	The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity.	Flavonoids	14-23	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	49-55
31480528-0	2019	The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity.	Flavonoids	14-23	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	57-63
31480528-0	2019	The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity.	Flavonoids	14-23	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	68-74
31480528-5	2019	Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes.	Flavonoids	60-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	101-107
31480528-5	2019	Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes.	Flavonoids	60-70	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	109-115
31480528-5	2019	Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes.	Flavonoids	60-70	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	117-123
31480528-5	2019	Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes.	Flavonoids	60-70	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	129-135
31166622-2	2019	The results of our previous studies have shown that the flavonoid monomer cyanidin-3-o-glucoside (C3G) can effectively inhibit primary human dermal fibroblast (HDF) oxidative damage and apoptosis caused by UVA radiation.	Flavonoids	56-65	Rap guanine nucleotide exchange factor 1	Homo sapiens	98-101
31315066-9	2019	Flavonoid-rich (EA) extracts with neohesperidin, hesperidin and naringin comprising 32.15%, were isolated from CAVA.	Flavonoids	0-9	carbonic anhydrase 5a, mitochondrial	Mus musculus	111-115
31894062-3	2019	Among tested flavonoids, the para substituted chloro containing flavonol (OF2) and flavone (F2) revealed a considerable in-vitro AChE and BuChE % inhibition with an IC50 values.	Flavonoids	13-23	acetylcholinesterase	Mus musculus	129-133
31894062-6	2019	The flavonoid derivatives showed significant effects on these changes by decreasing the ex-vivo AChE contents, enhancing the level of ACh, SOD and CAT suggesting their possible role as cholinesterase and antioxidant.	Flavonoids	4-13	acetylcholinesterase	Mus musculus	96-100
31894062-6	2019	The flavonoid derivatives showed significant effects on these changes by decreasing the ex-vivo AChE contents, enhancing the level of ACh, SOD and CAT suggesting their possible role as cholinesterase and antioxidant.	Flavonoids	4-13	catalase	Mus musculus	147-150
31894062-6	2019	The flavonoid derivatives showed significant effects on these changes by decreasing the ex-vivo AChE contents, enhancing the level of ACh, SOD and CAT suggesting their possible role as cholinesterase and antioxidant.	Flavonoids	4-13	butyrylcholinesterase	Mus musculus	185-199
31194956-3	2019	In the present study, we investigated the anti-AD potential of four flavonoids, naringenin, didymin, prunin, and poncirin, by evaluating their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).	Flavonoids	68-78	acetylcholinesterase	Rattus norvegicus	184-188
31322315-5	2019	Although some natural compounds such as terpenoids and alkaloids were reported to protect the nervous system by Nrf2 activating, flavonoids and phenolic compounds represent the majority of the reported neuroprotective natural substances that activate Nrf2.	Flavonoids	129-139	NFE2 like bZIP transcription factor 2	Homo sapiens	251-255
31872743-7	2019	These results suggested that the flavonoid mother nucleus structure had a special structure binding to the enzyme protein UGT1 A1,and the introduction of hydroxyl groups into the mother nucleus can increase the binding ability.	Flavonoids	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	122-129
31194956-4	2019	All four flavonoids displayed promising inhibitory activity against AChE, BChE, and BACE1.	Flavonoids	9-19	acetylcholinesterase	Rattus norvegicus	68-72
31194956-4	2019	All four flavonoids displayed promising inhibitory activity against AChE, BChE, and BACE1.	Flavonoids	9-19	butyrylcholinesterase	Rattus norvegicus	74-78
31194956-4	2019	All four flavonoids displayed promising inhibitory activity against AChE, BChE, and BACE1.	Flavonoids	9-19	beta-secretase 1	Rattus norvegicus	84-89
31194956-10	2019	In addition, pretreatment of PC12 cells with different concentrations of flavonoids for 1 h significantly reversed the effects of Abeta.	Flavonoids	73-83	amyloid beta precursor protein	Rattus norvegicus	130-135
31194956-11	2019	Furthermore, treatment with the most active flavonoid, didymin, significantly reduced BACE1, APPsbeta, and C99 expression levels in a dose-dependent manner, without affecting amyloid precursor protein (APP) levels in the amyloidogenic pathway.	Flavonoids	44-53	beta-secretase 1	Rattus norvegicus	86-91
30898717-4	2019	Genes encoding alcohol dehydrogenase 1 and hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase, involving in fatty acid degradation and flavonoid biosynthesis, were enriched.	Flavonoids	152-161	alcohol dehydrogenase 1	Gossypium arboreum	15-38
31438982-12	2019	RESULTS: The nearly 36,043 compounds from the Traditional Chinese Medicine (TCM) database were screened against COX-2, mPGES-1 and CYP4A11 3D models, and the 17 top flavonoids were identified.	Flavonoids	165-175	prostaglandin E synthase	Mus musculus	119-126
31438982-12	2019	RESULTS: The nearly 36,043 compounds from the Traditional Chinese Medicine (TCM) database were screened against COX-2, mPGES-1 and CYP4A11 3D models, and the 17 top flavonoids were identified.	Flavonoids	165-175	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	131-138
31438982-19	2019	CONCLUSIONS: Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-beta/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma.	Flavonoids	88-97	AKT serine/threonine kinase 1	Homo sapiens	126-129
31438982-19	2019	CONCLUSIONS: Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-beta/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma.	Flavonoids	88-97	fibroblast growth factor 2	Homo sapiens	131-136
31438982-19	2019	CONCLUSIONS: Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-beta/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma.	Flavonoids	88-97	transforming growth factor beta 1	Homo sapiens	137-145
31438982-19	2019	CONCLUSIONS: Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-beta/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma.	Flavonoids	88-97	vascular endothelial growth factor A	Homo sapiens	146-150
31438982-19	2019	CONCLUSIONS: Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-beta/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma.	Flavonoids	88-97	nuclear paraspeckle assembly transcript 1	Homo sapiens	207-212
30784273-3	2019	Binding with serum albumin and LDL of 41 polyphenols (major antioxidants in plant foods) constituting four classes of flavonoids, three types of phenolic acids, and seven polyphenol conjugate metabolites was investigated indirectly by fluorescence quenching and directly by affinity separation/high-performance liquid chromatography (four of the polyphenols).	Flavonoids	118-128	albumin	Homo sapiens	13-26
31313915-5	2019	This structure-based distribution across the spectral networks revealed the chemical composition of flavonoids across intra- and interspecies and guided the putatively assignment of 64 isomers and isobars in the Chrysobalanaceae plant species, most of which are not accurately annotated by automated untargeted MS2 matching.	Flavonoids	100-110	MS2	Homo sapiens	311-314
31434256-3	2019	First, potential flavonoids in lemonade were scanned and identified by ultra-performance liquid chromatography-time of flight mass spectrometry (UPLC-TOF/MS).	Flavonoids	17-27	FEZ family zinc finger 2	Homo sapiens	150-153
31443416-2	2019	In this work, flavonoids isolated from bamboo residues (BRF) were applied as fluorescence sensors for different metal cations" detection in vitro.	Flavonoids	14-24	BRF1 RNA polymerase III transcription initiation factor subunit	Homo sapiens	56-59
31438605-0	2019	Interaction Mechanism of Flavonoids and alpha-Glucosidase: Experimental and Molecular Modelling Studies.	Flavonoids	25-35	sucrase-isomaltase	Homo sapiens	40-57
31438605-1	2019	Flavonoids are known to play a role in hypoglycemia by inhibiting alpha-glucosidase.	Flavonoids	0-10	sucrase-isomaltase	Homo sapiens	66-83
31438605-3	2019	In this study, the alpha-glucosidase inhibitory activities of 15 flavonoids were investigated.	Flavonoids	65-75	sucrase-isomaltase	Homo sapiens	19-36
31251921-8	2019	In addition, this flavonoid also inhibited the overproduction of nitric oxide and inflammatory cytokines in LPS-stimulated macrophages via simultaneous induction of HO-1 expression.	Flavonoids	18-27	heme oxygenase 1	Mus musculus	165-169
31431821-6	2019	Highly expressed miR-155 has been downregulated by flavonoids (through a quercetin-rich diet) and by vitamin D.	Flavonoids	51-61	microRNA 155	Homo sapiens	17-24
31132359-0	2019	Structure characteristics of flavonoids for cyclooxygenase-2 mRNA inhibition in lipopolysaccharide-induced inflammatory macrophages.	Flavonoids	29-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-60
31132359-4	2019	And structure characteristics of flavonoids for COX-2 inhibition were mainly analyzed by a quantitative structure activity relationship (QSAR) model.	Flavonoids	33-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
31132359-13	2019	Also, methoxyl groups at C-4" may also be a favorable flavonoid structural characteristic for COX-2 mRNA inhibiton.	Flavonoids	54-63	complement C4A (Rodgers blood group)	Homo sapiens	25-28
31132359-13	2019	Also, methoxyl groups at C-4" may also be a favorable flavonoid structural characteristic for COX-2 mRNA inhibiton.	Flavonoids	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
31195342-0	2019	Citrus flavonoid 3,5,6,7,8,3",4"-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells.	Flavonoids	7-16	brain-derived neurotrophic factor	Rattus norvegicus	61-65
31382634-0	2019	Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation.	Flavonoids	35-44	vascular cell adhesion molecule 1	Homo sapiens	19-25
31382634-6	2019	We found that flavonoid-loaded LNs, either non-targeted or targeted to the endothelium, were taken up by the EA.hy926 cells in a dose-dependent manner, but dependent on TNF-alpha only in the case of endothelium-targeted LNs.	Flavonoids	14-23	tumor necrosis factor	Homo sapiens	169-178
31071329-0	2019	Natural flavonoids inhibit the plasma membrane Ca2+-ATPase.	Flavonoids	8-18	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	31-58
31071329-4	2019	The present study aims to investigate the effect of several natural flavonoids on PMCA both in isolated protein systems and in living cells, and to establish the relationship between flavonoid structure and inhibitory activity on PMCA.	Flavonoids	68-78	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	82-86
31071329-4	2019	The present study aims to investigate the effect of several natural flavonoids on PMCA both in isolated protein systems and in living cells, and to establish the relationship between flavonoid structure and inhibitory activity on PMCA.	Flavonoids	68-77	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	82-86
31071329-5	2019	Our results show that natural flavonoids inhibited purified and membranous PMCA with different effectiveness: quercetin and gossypin were the most potent and their inhibition mechanisms seem to be different, as quercetin does not prevent ATP binding whereas gossypin does.	Flavonoids	30-40	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	75-79
31071329-7	2019	In conclusion, this work reveals a novel molecular mechanism through which flavonoids inhibit PMCA, which leads to Ca2+ homeostasis and signaling alterations in the cell.	Flavonoids	75-85	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	94-98
30790292-4	2019	Oroxylin A (C16H12O5), a bioactive flavonoid, could induce HIF-1alpha degradation via prolyl-hydroxylases-VHL signaling pathway, resulting in the inactivation of the hedgehog.	Flavonoids	35-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
30357845-8	2019	In both expression systems there were indications that the A. thaliana PRODUCTION OF ANTHOCYANIN PIGMENT1 (AtPAP1), a MYB transcription factor of flavonoid biosynthesis, increased the activity of the CsANS promoter, while AtHB2 could significantly undermine the effect of AtPAP1.	Flavonoids	146-155	production of anthocyanin pigment 1	Arabidopsis thaliana	71-105
30357845-8	2019	In both expression systems there were indications that the A. thaliana PRODUCTION OF ANTHOCYANIN PIGMENT1 (AtPAP1), a MYB transcription factor of flavonoid biosynthesis, increased the activity of the CsANS promoter, while AtHB2 could significantly undermine the effect of AtPAP1.	Flavonoids	146-155	phosphatidic acid phosphatase 1	Arabidopsis thaliana	107-113
30357845-8	2019	In both expression systems there were indications that the A. thaliana PRODUCTION OF ANTHOCYANIN PIGMENT1 (AtPAP1), a MYB transcription factor of flavonoid biosynthesis, increased the activity of the CsANS promoter, while AtHB2 could significantly undermine the effect of AtPAP1.	Flavonoids	146-155	homeobox protein 2	Arabidopsis thaliana	222-227
30357845-8	2019	In both expression systems there were indications that the A. thaliana PRODUCTION OF ANTHOCYANIN PIGMENT1 (AtPAP1), a MYB transcription factor of flavonoid biosynthesis, increased the activity of the CsANS promoter, while AtHB2 could significantly undermine the effect of AtPAP1.	Flavonoids	146-155	phosphatidic acid phosphatase 1	Arabidopsis thaliana	272-278
31428108-6	2019	The enzymes that form the flavonoid scaffold structures probably first appeared by recruitment of enzymes from primary metabolic pathways, and later, enzymes that belong to superfamilies such as 2-oxoglutarate-dependent dioxygenase, cytochrome P450, and short-chain dehydrogenase/reductase modified and varied the structures.	Flavonoids	26-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	233-289
31199942-11	2019	These results suggest that Erk-5 could be a critical regulator of oxLDL-induced EC death, inflammation and dysfunction via downregulation of Erk-5/Mef2c-KLF2 signaling pathway, which can be ameliorated by a bioflavonoid, fisetin.	Flavonoids	207-219	mitogen-activated protein kinase 7	Homo sapiens	27-32
31199942-11	2019	These results suggest that Erk-5 could be a critical regulator of oxLDL-induced EC death, inflammation and dysfunction via downregulation of Erk-5/Mef2c-KLF2 signaling pathway, which can be ameliorated by a bioflavonoid, fisetin.	Flavonoids	207-219	mitogen-activated protein kinase 7	Homo sapiens	141-146
31199942-11	2019	These results suggest that Erk-5 could be a critical regulator of oxLDL-induced EC death, inflammation and dysfunction via downregulation of Erk-5/Mef2c-KLF2 signaling pathway, which can be ameliorated by a bioflavonoid, fisetin.	Flavonoids	207-219	myocyte enhancer factor 2C	Homo sapiens	147-152
31199942-11	2019	These results suggest that Erk-5 could be a critical regulator of oxLDL-induced EC death, inflammation and dysfunction via downregulation of Erk-5/Mef2c-KLF2 signaling pathway, which can be ameliorated by a bioflavonoid, fisetin.	Flavonoids	207-219	Kruppel like factor 2	Homo sapiens	153-157
31047931-4	2019	The results clearly demonstrate that most of naphthodianthrones, flavonoids and biflavones exhibit strong to moderate inhibition on human thrombin.	Flavonoids	65-75	coagulation factor II, thrombin	Homo sapiens	138-146
31195342-0	2019	Citrus flavonoid 3,5,6,7,8,3",4"-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells.	Flavonoids	7-16	cathelicidin antimicrobial peptide	Rattus norvegicus	70-74
31195342-0	2019	Citrus flavonoid 3,5,6,7,8,3",4"-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells.	Flavonoids	7-16	Eph receptor B1	Rattus norvegicus	75-78
31195342-0	2019	Citrus flavonoid 3,5,6,7,8,3",4"-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells.	Flavonoids	7-16	cAMP responsive element binding protein 1	Rattus norvegicus	79-83
31195342-2	2019	In our previous in vivo studies using ischemic and depression mouse models, we revealed that citrus flavonoid 3,5,6,7,8,3",4"-heptamethoxyflavone (HMF) exerts neuroprotective effects by enhancing the expression of BDNF in astrocytes within the hippocampus.	Flavonoids	100-109	brain derived neurotrophic factor	Mus musculus	214-218
31166333-1	2019	The UVR8 photoreceptor in Arabidopsis thaliana is specific for ultraviolet-B (UV-B; 280-315 nm) radiation and its activation leads to a number of UV-B acclimation responses, including the accumulation of flavonoids.	Flavonoids	204-214	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	4-8
31021017-5	2019	Overexpression of MYB6 in transgenic poplar upregulated flavonoid biosynthetic gene expression, resulting in significantly increased accumulation of anthocyanin and proanthocyanidins.	Flavonoids	56-65	myb domain protein 6	Arabidopsis thaliana	18-22
31323752-4	2019	Flavonoids 1, 2, 5, 6, 8, and 10-12 significantly inhibited NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) and glutamate-induced cell toxicity and effectively increased HO-1 protein expression in mouse hippocampal HT22 cells.	Flavonoids	0-10	heme oxygenase 1	Mus musculus	194-198
31323752-5	2019	Flavonoids with significant neuroprotective activity were also found to recover oxidative-stress-induced cell damage by increasing HO-1 protein expression.	Flavonoids	0-10	heme oxygenase 1	Mus musculus	131-135
31346342-8	2019	Flavonoids activated the sympathetic nervous system (SNS), promoted the release of adrenaline and thyroid hormones to increase thermogenesis and induced WAT browning through the AMPK-PGC-1alpha/Sirt1 and PPAR signalling pathways.	Flavonoids	0-10	PPARG coactivator 1 alpha	Homo sapiens	183-193
31346342-8	2019	Flavonoids activated the sympathetic nervous system (SNS), promoted the release of adrenaline and thyroid hormones to increase thermogenesis and induced WAT browning through the AMPK-PGC-1alpha/Sirt1 and PPAR signalling pathways.	Flavonoids	0-10	sirtuin 1	Homo sapiens	194-199
31346342-8	2019	Flavonoids activated the sympathetic nervous system (SNS), promoted the release of adrenaline and thyroid hormones to increase thermogenesis and induced WAT browning through the AMPK-PGC-1alpha/Sirt1 and PPAR signalling pathways.	Flavonoids	0-10	peroxisome proliferator activated receptor alpha	Homo sapiens	204-208
31371989-0	2019	The total flavonoid of Eucommia ulmoides sensitizes human glioblastoma cells to radiotherapy via HIF-alpha/MMP-2 pathway and activates intrinsic apoptosis pathway.	Flavonoids	10-19	matrix metallopeptidase 2	Homo sapiens	107-112
31371989-15	2019	By examining the expression of important genes of radioresistant pathway, we found a significant decrease of HIF-alpha/MMP-2 when using the total flavonoid of Eucommia ulmoides during radiotherapy.	Flavonoids	146-155	matrix metallopeptidase 2	Homo sapiens	119-124
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	174-184	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	0-4
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	174-184	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	51-55
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	174-184	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	60-63
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	174-184	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	204-208
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	292-302	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	0-4
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	292-302	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	51-55
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	292-302	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	60-63
31166333-2	2019	UVR8 participates in a signaling cascade involving COP1 and HY5 so that the absence of any of these components results in a reduction in the ability of a plant to accumulate flavonoids in response to UV; Cop1 mutants show high dropouts and hy5-ks50 hyh double mutants show very low levels of flavonoids.	Flavonoids	292-302	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	204-208
30624861-4	2019	This study aims to evaluate the inhibitory potential of 14 flavonoids on TNF-alpha release in human whole blood as well as the inhibitory potential of myricetin towards kinases involved in tumorigenesis.	Flavonoids	59-69	tumor necrosis factor	Homo sapiens	73-82
31003047-3	2019	In this work, the inhibition potency of several naturally occurring flavonoid compounds was studied against aggregation of human gammaD-crystallin (HGD) mediated by copper ions.	Flavonoids	68-77	crystallin gamma D	Homo sapiens	129-146
31059754-0	2019	Flavonoid loaded nanoparticles as an effective measure to combat oxidative stress in Ribonuclease A.	Flavonoids	0-9	ribonuclease A family member 1, pancreatic	Homo sapiens	85-99
30624861-5	2019	Our results showed that, out of all flavonoids, myricetin had the highest inhibitory effect on TNF-alpha level.	Flavonoids	36-46	tumor necrosis factor	Homo sapiens	95-104
31094018-1	2019	A previous report indicated that the flavonoid-rich extract of bergamot juice (BJe) exerts an anti-inflammatory effect through the activation of SIRT1 in leukemic monocytes THP-1 exposed to lipopolysaccharide (LPS).	Flavonoids	37-46	sirtuin 1	Homo sapiens	145-150
31094018-1	2019	A previous report indicated that the flavonoid-rich extract of bergamot juice (BJe) exerts an anti-inflammatory effect through the activation of SIRT1 in leukemic monocytes THP-1 exposed to lipopolysaccharide (LPS).	Flavonoids	37-46	GLI family zinc finger 2	Homo sapiens	173-178
31094018-2	2019	In this study, we deeply investigate the mode of action of BJe, along with its major flavonoids on SIRT1 through cell-free, in silico, and in vitro experimental models.	Flavonoids	85-95	sirtuin 1	Homo sapiens	99-104
31094018-5	2019	In THP-1 cells exposed to LPS, a reduction of SIRT1 activity was observed, effect that was reverted by the pre-incubation with either BJe or its major flavonoids.	Flavonoids	151-161	GLI family zinc finger 2	Homo sapiens	3-8
31254216-3	2019	Flavonoids such as anthocyanidins, which are found abundantly in fruits and vegetables, have been shown to activate Nrf2.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
31094018-5	2019	In THP-1 cells exposed to LPS, a reduction of SIRT1 activity was observed, effect that was reverted by the pre-incubation with either BJe or its major flavonoids.	Flavonoids	151-161	sirtuin 1	Homo sapiens	46-51
31094018-7	2019	Employing an activator and an inhibitor of AMP-activated protein kinase (AMPK; AICAR and dorsomorphin, respectively), we discovered its involvement in the activation of SIRT1 elicited by BJe or its major flavonoids in whole cell.	Flavonoids	204-214	sirtuin 1	Homo sapiens	169-174
30048196-7	2019	CYP1A2 and CYP2B6 were also found to play significant roles in some of the oxidations of these flavonoids by human liver microsomes.	Flavonoids	95-105	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
30048196-7	2019	CYP1A2 and CYP2B6 were also found to play significant roles in some of the oxidations of these flavonoids by human liver microsomes.	Flavonoids	95-105	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	11-17
31234550-7	2019	In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified.	Flavonoids	64-74	superoxide dismutase 1	Homo sapiens	104-107
30959046-11	2019	Therefore, the combination therapy of anticancer drugs and flavonoid-like GBD is a promising strategy to overcome P-gp-mediated MDR.	Flavonoids	59-68	ATP binding cassette subfamily B member 1	Homo sapiens	114-118
30964977-2	2019	In order to better understand the metabolism of these flavonoids in humans, we examined the oxidation of flavone, 5-hydroxyflavone (5OHF), and 57diOHF to various products by human cytochrome P450 (P450 or CYP) and liver microsomal enzymes.	Flavonoids	54-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	180-195
30964977-2	2019	In order to better understand the metabolism of these flavonoids in humans, we examined the oxidation of flavone, 5-hydroxyflavone (5OHF), and 57diOHF to various products by human cytochrome P450 (P450 or CYP) and liver microsomal enzymes.	Flavonoids	54-64	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	197-208
31209339-3	2019	The GL2 gene encode a transcription factor controlling the balance between the biosynthesis of fatty acids in the embryo and the production of mucilage and flavonoid pigments in the seed coat.	Flavonoids	156-165	HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein	Arabidopsis thaliana	4-7
31275340-6	2019	Transcriptomic analysis of TDR4-silenced fruit showed changes in the expression of genes involved in various metabolic pathways, including amino acid and flavonoid biosynthesis pathways.	Flavonoids	154-163	agamous-like MADS-box protein AGL8 homolog	Solanum lycopersicum	27-31
30872054-0	2019	Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations.	Flavonoids	0-10	carboxylesterase 2	Homo sapiens	20-38
30872054-1	2019	In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products, we investigated inhibitory effects and mechanisms of flavonoids (1-16) against hCE 2.	Flavonoids	146-156	carboxylesterase 2	Homo sapiens	172-177
31174258-0	2019	Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse.	Flavonoids	29-38	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	111-117
31174258-3	2019	7,8-dihydroxyflavone (7,8-DHF), a flavonoid that targets the tropomyosin-related kinase B (TrkB) receptor of brain-derived neurotrophic factor (BDNF), exerts positive effects in various brain disease models.	Flavonoids	34-43	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	61-89
31174258-3	2019	7,8-dihydroxyflavone (7,8-DHF), a flavonoid that targets the tropomyosin-related kinase B (TrkB) receptor of brain-derived neurotrophic factor (BDNF), exerts positive effects in various brain disease models.	Flavonoids	34-43	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	91-95
31174258-3	2019	7,8-dihydroxyflavone (7,8-DHF), a flavonoid that targets the tropomyosin-related kinase B (TrkB) receptor of brain-derived neurotrophic factor (BDNF), exerts positive effects in various brain disease models.	Flavonoids	34-43	brain derived neurotrophic factor	Mus musculus	109-142
31174258-3	2019	7,8-dihydroxyflavone (7,8-DHF), a flavonoid that targets the tropomyosin-related kinase B (TrkB) receptor of brain-derived neurotrophic factor (BDNF), exerts positive effects in various brain disease models.	Flavonoids	34-43	brain derived neurotrophic factor	Mus musculus	144-148
31022396-9	2019	These flavonoids also inhibited the activation of pro-apoptotic kinases (p38 MAPK and c-Jun N-terminal kinase) during HR-induced phosphorylation.	Flavonoids	6-16	mitogen-activated protein kinase 14	Homo sapiens	73-76
31214028-0	2019	Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology.	Flavonoids	51-61	vascular endothelial growth factor C	Mus musculus	14-20
31049822-0	2019	Flavonoid morin inhibits proliferation and induces apoptosis of melanoma cells by regulating reactive oxygen species, Sp1 and Mcl-1.	Flavonoids	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	126-131
30933784-4	2019	Comparison of the inhibitory activities of 1a vs. 9a vs. 13a and 1b vs. 7b vs. 11b suggested that methoxy substitution at R1 on the A-rings of flavonoids increases MAO-A inhibition whereas methoxy substitution at R2 increased MAO-B inhibition.	Flavonoids	143-153	monoamine oxidase A	Homo sapiens	164-169
30933784-4	2019	Comparison of the inhibitory activities of 1a vs. 9a vs. 13a and 1b vs. 7b vs. 11b suggested that methoxy substitution at R1 on the A-rings of flavonoids increases MAO-A inhibition whereas methoxy substitution at R2 increased MAO-B inhibition.	Flavonoids	143-153	monoamine oxidase B	Homo sapiens	226-231
30723906-0	2019	Lupin seeds storage protein composition and their interactions with native flavonoids.	Flavonoids	75-85	5'-nucleotidase, cytosolic IIIA	Homo sapiens	0-5
31034797-0	2019	Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells.	Flavonoids	47-57	G protein-coupled estrogen receptor 1	Rattus norvegicus	14-43
31034797-0	2019	Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells.	Flavonoids	47-57	acetylcholinesterase	Rattus norvegicus	81-101
31034797-2	2019	The role of flavonoids in induction of a cholinergic enzyme, acetylcholinesterase (AChE), was being explored here.	Flavonoids	12-22	acetylcholinesterase	Rattus norvegicus	61-81
31034797-2	2019	The role of flavonoids in induction of a cholinergic enzyme, acetylcholinesterase (AChE), was being explored here.	Flavonoids	12-22	acetylcholinesterase	Rattus norvegicus	83-87
31034797-3	2019	In cultured PC12 cells, twenty-four commonly found flavonoids were tested for its induction on AChE activity.	Flavonoids	51-61	acetylcholinesterase	Rattus norvegicus	95-99
31034797-8	2019	Taken together, flavonoids could induce the expression of AChE via GPR 30 in cultured PC12 cells, which could be a good candidate for possible treatment of the brain diseases.	Flavonoids	16-26	acetylcholinesterase	Rattus norvegicus	58-62
31034797-8	2019	Taken together, flavonoids could induce the expression of AChE via GPR 30 in cultured PC12 cells, which could be a good candidate for possible treatment of the brain diseases.	Flavonoids	16-26	G protein-coupled estrogen receptor 1	Rattus norvegicus	67-73
31029788-2	2019	The effects of flavonoids shown to improve endothelial performance include regulating blood pressure by modulating endothelial nitric oxide synthase and NADPH oxidases, but their impact on glucose uptake and metabolism has not been explored.	Flavonoids	15-25	nitric oxide synthase 3	Homo sapiens	115-148
30341909-4	2019	Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells.	Flavonoids	124-133	cadherin 1	Homo sapiens	199-209
30341909-4	2019	Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells.	Flavonoids	124-133	cadherin 2	Homo sapiens	262-272
30341909-4	2019	Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells.	Flavonoids	124-133	vimentin	Homo sapiens	274-282
30341909-4	2019	Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells.	Flavonoids	124-133	prominin 1	Homo sapiens	288-293
30341909-4	2019	Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells.	Flavonoids	124-133	twist family bHLH transcription factor 1	Homo sapiens	357-362
31116430-0	2019	Bamboo Leaf Flavonoids Extracts Alleviate Oxidative Stress in HepG2 Cells via Naturally Modulating Reactive Oxygen Species Production and Nrf2-Mediated Antioxidant Defense Responses.	Flavonoids	12-22	NFE2 like bZIP transcription factor 2	Homo sapiens	138-142
31093947-3	2019	The main goal of this study was to evaluate the effect of hesperetin, a citrus polyphenolic flavonoid, on SIRT1 and AMP-activated kinase (AMPK).	Flavonoids	92-101	sirtuin 1	Homo sapiens	106-111
31093947-3	2019	The main goal of this study was to evaluate the effect of hesperetin, a citrus polyphenolic flavonoid, on SIRT1 and AMP-activated kinase (AMPK).	Flavonoids	92-101	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	116-136
31093947-3	2019	The main goal of this study was to evaluate the effect of hesperetin, a citrus polyphenolic flavonoid, on SIRT1 and AMP-activated kinase (AMPK).	Flavonoids	92-101	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	138-142
30723906-7	2019	The lowest flavonoids content was noted in the main storage proteins while in both lupin seeds species over 90% of flavonoids interacted with the proteins present in late-embryogenesis abundant (LEA) protein fraction.	Flavonoids	115-125	5'-nucleotidase, cytosolic IIIA	Homo sapiens	83-88
31328126-5	2019	In the present study, we investigated the effects of flavonoid myricetin on expression of cyclooxygenase 2 (COX-2) in the H9c2 cells treated with PGN from Streptococcus sanguinis, a bacterial constituent of dental plaque associated with infective endocarditis.	Flavonoids	53-62	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	90-106
30500074-10	2019	Furthermore, attenuation of neclear factor-kappaB and signal transducer and activator of transcription 3 activation, suppression of signaling pathway and downregulation of intracellular antiapoptotic proteins are other significant antileukemic function mechanism of flavonoids.	Flavonoids	266-276	signal transducer and activator of transcription 3	Homo sapiens	54-104
31328126-5	2019	In the present study, we investigated the effects of flavonoid myricetin on expression of cyclooxygenase 2 (COX-2) in the H9c2 cells treated with PGN from Streptococcus sanguinis, a bacterial constituent of dental plaque associated with infective endocarditis.	Flavonoids	53-62	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	108-113
31159225-5	2019	This flavonoid is able to counteract the proliferative effects of IL-22/IL6 pathway by the inhibition of STAT3 activity also in vivo in a psoriatic mouse model.	Flavonoids	5-14	interleukin 22	Mus musculus	66-71
31159225-5	2019	This flavonoid is able to counteract the proliferative effects of IL-22/IL6 pathway by the inhibition of STAT3 activity also in vivo in a psoriatic mouse model.	Flavonoids	5-14	interleukin 6	Mus musculus	72-75
31159225-5	2019	This flavonoid is able to counteract the proliferative effects of IL-22/IL6 pathway by the inhibition of STAT3 activity also in vivo in a psoriatic mouse model.	Flavonoids	5-14	signal transducer and activator of transcription 3	Mus musculus	105-110
31191562-6	2019	Through non-catalytic, so-called ligandin properties, numerous plant GSTs also participate in the binding and transport of small heterocyclic ligands such as flavonoids including anthocyanins, and polyphenols.	Flavonoids	158-168	hematopoietic prostaglandin D synthase	Homo sapiens	69-73
30864408-0	2019	Bioflavonoids protect cells against halogenated boroxine-induced genotoxic damage by upregulation of hTERT expression.	Flavonoids	0-13	telomerase reverse transcriptase	Homo sapiens	101-106
30864408-8	2019	The obtained results have shown that selected bioflavonoids induce upregulation of hTERT that may contribute to the repair of genotoxic damage in vitro.	Flavonoids	46-59	telomerase reverse transcriptase	Homo sapiens	83-88
31096923-8	2019	We found that more than 77 DEGs were related to flavonoid and lignin biosynthesis, including 4CL, C4H, and PAL, which participated in phenylalanine metabolism, and BAN, CHI/TT5, DFR, F3H, FLS, LDOX, PAP, CHS/TT4, TT5, bHLH/TT8, WD40, MYB, TCP, and CYP, which were involved in flavonoid biosynthesis.	Flavonoids	48-57	transcription factor TT8	Brassica napus	223-226
31096923-8	2019	We found that more than 77 DEGs were related to flavonoid and lignin biosynthesis, including 4CL, C4H, and PAL, which participated in phenylalanine metabolism, and BAN, CHI/TT5, DFR, F3H, FLS, LDOX, PAP, CHS/TT4, TT5, bHLH/TT8, WD40, MYB, TCP, and CYP, which were involved in flavonoid biosynthesis.	Flavonoids	48-57	peptidyl-prolyl cis-trans isomerase	Brassica napus	248-251
30612424-0	2019	Flavonoids Alleviating Insulin Resistance through Inhibition of Inflammatory Signaling.	Flavonoids	0-10	insulin	Homo sapiens	23-30
31100782-4	2019	Flavonoids target several signaling pathways involved in apoptosis, cell cycle arrest, mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT kinase, and metastasis.	Flavonoids	0-10	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	128-153
31100782-6	2019	Recent studies suggest that several flavonoids, including genistein directly inhibit PLK1 inhibitory activity.	Flavonoids	36-46	polo like kinase 1	Homo sapiens	85-89
30612424-4	2019	Given the putative relationship between inflammation and insulin resistance, the consumption of flavonoids or flavonoid-rich foods has been suggested to reduce the risk of diabetes by targeting inflammatory signals.	Flavonoids	96-106	insulin	Homo sapiens	57-64
30612424-4	2019	Given the putative relationship between inflammation and insulin resistance, the consumption of flavonoids or flavonoid-rich foods has been suggested to reduce the risk of diabetes by targeting inflammatory signals.	Flavonoids	96-105	insulin	Homo sapiens	57-64
30612424-5	2019	This is the first comprehensive review summarizing the current research progress on the inhibition of inflammation and alleviation of insulin resistance by flavonoids as well as the mechanistic link between these disorders.	Flavonoids	156-166	insulin	Homo sapiens	134-141
31092862-0	2019	Determination and analysis of agonist and antagonist potential of naturally occurring flavonoids for estrogen receptor (ERalpha) by various parameters and molecular modelling approach.	Flavonoids	86-96	estrogen receptor 1	Homo sapiens	101-118
30838366-8	2019	Whereas HY5 accumulation correlates well with the UVR8 signal across cell layers, the induction of flavonoids depends on both UVR8 signal and a yet to be identified tissue-dependent or developmental determinant.	Flavonoids	99-109	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	126-130
31092862-0	2019	Determination and analysis of agonist and antagonist potential of naturally occurring flavonoids for estrogen receptor (ERalpha) by various parameters and molecular modelling approach.	Flavonoids	86-96	estrogen receptor 1	Homo sapiens	120-127
31092862-4	2019	During the molecular modelling studies of some naturally occurring flavonoids such as quercetin, luteolin, myricetin, kaempferol, naringin, hesperidin, galangin, baicalein and epicatechin with human ERalpha (3ERT and 1GWR), we observed that most of the ligands bound to the active site pocket of both 3ERT and 1GWR.	Flavonoids	67-77	estrogen receptor 1	Homo sapiens	199-206
31053173-9	2019	Both flavonoids simultaneously changed the expression of the glycolytic pathway genes - HK2 and LDHA, which play a key role in the Warburg effect.	Flavonoids	5-15	hexokinase 2	Homo sapiens	88-91
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Flavonoids	57-67	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	171-177
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Flavonoids	57-67	sterol regulatory element binding transcription factor 2	Homo sapiens	178-184
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Flavonoids	57-67	low density lipoprotein receptor	Homo sapiens	185-189
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Flavonoids	57-67	hepatocyte nuclear factor 4 alpha	Homo sapiens	199-208
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Flavonoids	57-67	apolipoprotein B	Homo sapiens	213-217
31058806-3	2019	To study the effect of Wu Shan Shen Cha-derived flavonoids (WSSCF) on lesions in the stomach, a 15% hydrochloric acid-95% ethanol (volume ratio 4:6) solution was used to induce gastric injury in mice.	Flavonoids	48-58	POC1 centriolar protein A	Mus musculus	36-39
31058806-8	2019	Wu Shan Shen Cha-derived flavonoids had a good antioxidant effect, so as to play a preventive role in alcoholic gastric injury.	Flavonoids	25-35	POC1 centriolar protein A	Mus musculus	13-16
31053173-9	2019	Both flavonoids simultaneously changed the expression of the glycolytic pathway genes - HK2 and LDHA, which play a key role in the Warburg effect.	Flavonoids	5-15	lactate dehydrogenase A	Homo sapiens	96-100
31061619-0	2019	Flavonoids from Camellia sinensis (L.) O. Kuntze seed ameliorates TNF-alpha induced insulin resistance in HepG2 cells.	Flavonoids	0-10	tumor necrosis factor	Homo sapiens	66-75
31433724-0	2019	Dietary natural flavonoids treating cancer by targeting aryl hydrocarbon receptor.	Flavonoids	16-26	aryl hydrocarbon receptor	Homo sapiens	56-81
31433724-6	2019	Of note, numerous natural products contribute to AhR active, of which dietary flavonoids are the largest class of natural AhR ligands.	Flavonoids	78-88	aryl hydrocarbon receptor	Homo sapiens	49-52
31433724-6	2019	Of note, numerous natural products contribute to AhR active, of which dietary flavonoids are the largest class of natural AhR ligands.	Flavonoids	78-88	aryl hydrocarbon receptor	Homo sapiens	122-125
31433724-10	2019	Ultimately, we summarize and highlight the latest progression of dietary flavonoids as AhR ligands in cancer inhibition, including the limitations and deficiencies of it in clinical research.	Flavonoids	73-83	aryl hydrocarbon receptor	Homo sapiens	87-90
30898639-2	2019	In order to increase the lipophilicity of the flavonoid and to dissolve it in SEDDS, enzymatic acylation of rutin with lauric acid was catalyzed by lipase from Candida antarctica in acetone.	Flavonoids	46-55	PAN0_003d1715	Moesziomyces antarcticus	148-154
30955153-1	2019	Lysosome selective bright orange-red emitting flavonoid (2) was synthesized by attaching a strong donor (NPh2) group into flavonoid skeleton.	Flavonoids	46-55	neurexophilin 2	Homo sapiens	105-109
30955153-1	2019	Lysosome selective bright orange-red emitting flavonoid (2) was synthesized by attaching a strong donor (NPh2) group into flavonoid skeleton.	Flavonoids	122-131	neurexophilin 2	Homo sapiens	105-109
30897399-2	2019	In addition, expression of photoreceptor genes Cry1, Cry2 and UVR8, photomorphogenetic gene COP1 and transcription factors genes HY5, HYH, the gene of chlorophyll-binding protein of the PSII CAB1 as well as the flavonoid biosynthesis genes CHS, PAL and thylakoid ascorbate peroxidase gene tAPX was examined.	Flavonoids	211-220	chlorophyll A/B binding protein 1	Arabidopsis thaliana	191-195
30785766-12	2019	The food flavonoid quercetin was a TRPC-6 inducer and activator and it could prevent adipogenesis in mice.-Tan, Y. Q., Kwan, H. Y., Yao, X., Leung, L. K. The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells.	Flavonoids	9-18	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	35-41
30585631-2	2019	Purple sweet potato color (PSPC), one type of flavonoid, has been demonstrated to suppress endothelial senescence and restore endothelial function in diabetic mice by inhibiting the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome.	Flavonoids	46-55	NLR family, pyrin domain containing 3	Mus musculus	284-289
31061619-0	2019	Flavonoids from Camellia sinensis (L.) O. Kuntze seed ameliorates TNF-alpha induced insulin resistance in HepG2 cells.	Flavonoids	0-10	insulin	Homo sapiens	84-91
31061619-1	2019	The aim of this study is to discuss the non-catechin flavonoids (NCF) from Camellia sinensis (L.) O. Kuntze seed improving TNF-alpha impaired insulin stimulated glucose uptake and insulin signaling.	Flavonoids	53-63	tumor necrosis factor	Homo sapiens	123-132
31061619-1	2019	The aim of this study is to discuss the non-catechin flavonoids (NCF) from Camellia sinensis (L.) O. Kuntze seed improving TNF-alpha impaired insulin stimulated glucose uptake and insulin signaling.	Flavonoids	53-63	insulin	Homo sapiens	142-149
31035509-3	2019	Pinocembrin, the most abundant flavonoid in propolis, has been recently proven to interfere with RAGE activation in Abeta-RAGE-induced toxicity.	Flavonoids	31-40	advanced glycosylation end-product specific receptor	Homo sapiens	97-101
31035637-0	2019	The Flavonoid Quercetin Induces AP-1 Activation in FRTL-5 Thyroid Cells.	Flavonoids	4-13	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-36
30790579-3	2019	The aim of this study was to investigate the inhibitory effects of 75 flavonoids on P-gp in vitro and in vivo and to illuminate the structure-activity relationships of flavonoids with P-gp.	Flavonoids	70-80	ATP binding cassette subfamily B member 1	Homo sapiens	84-88
31035631-0	2019	Quantitative Structure-Activity Relationships for the Flavonoid-Mediated Inhibition of P-Glycoprotein in KB/MDR1 Cells.	Flavonoids	54-63	ATP binding cassette subfamily B member 1	Homo sapiens	87-101
31035631-0	2019	Quantitative Structure-Activity Relationships for the Flavonoid-Mediated Inhibition of P-Glycoprotein in KB/MDR1 Cells.	Flavonoids	54-63	ATP binding cassette subfamily B member 1	Homo sapiens	108-112
31035631-3	2019	Besides several chemically synthesized P-gp inhibitors, flavonoids as P-gp inhibitors are being investigated, with their advantages including abundance in our daily diet and a low toxicity.	Flavonoids	56-66	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
31035631-8	2019	These results are important for the screening of flavonoids for inhibitory activity on P-gp.	Flavonoids	49-59	ATP binding cassette subfamily B member 1	Homo sapiens	87-91
31027340-2	2019	Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies.	Flavonoids	38-48	insulin	Homo sapiens	80-87
31027340-3	2019	The aim of this review is to analyse the data observed in vitro, in vivo and in clinical trials concerning the effects of flavonoids on insulin resistance and to determine the molecular mechanisms with which flavonoids interact with insulin signaling.	Flavonoids	122-132	insulin	Homo sapiens	136-143
31027340-3	2019	The aim of this review is to analyse the data observed in vitro, in vivo and in clinical trials concerning the effects of flavonoids on insulin resistance and to determine the molecular mechanisms with which flavonoids interact with insulin signaling.	Flavonoids	208-218	insulin	Homo sapiens	233-240
31020859-0	2021	Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats.	Flavonoids	15-24	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	30-44
31020859-1	2021	P-glycoprotein (P-gp) is an efflux transporter involved in drug-resistant epilepsy and some flavonoids have been targeted as effective P-gp inhibitors.	Flavonoids	92-102	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	0-14
31020859-1	2021	P-glycoprotein (P-gp) is an efflux transporter involved in drug-resistant epilepsy and some flavonoids have been targeted as effective P-gp inhibitors.	Flavonoids	92-102	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	16-20
31020859-1	2021	P-glycoprotein (P-gp) is an efflux transporter involved in drug-resistant epilepsy and some flavonoids have been targeted as effective P-gp inhibitors.	Flavonoids	92-102	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	135-139
31060166-15	2019	In addition, the concentrations of IL-1beta and IL-6 decreased [(21.79+-3.95) pg/ml vs (31.78+-4.12) pg/ml, (34.68+-4.28) pg/ml vs (49.15+-3.47) pg/ml, both P&lt;0.01] and the expressions of RAGE, p-P38, nuclear NF-kappaB, cleaved caspase-3 up-regulated in the bamboo leaf flavonoid group.	Flavonoids	273-282	interleukin 1 beta	Rattus norvegicus	35-43
31060166-15	2019	In addition, the concentrations of IL-1beta and IL-6 decreased [(21.79+-3.95) pg/ml vs (31.78+-4.12) pg/ml, (34.68+-4.28) pg/ml vs (49.15+-3.47) pg/ml, both P&lt;0.01] and the expressions of RAGE, p-P38, nuclear NF-kappaB, cleaved caspase-3 up-regulated in the bamboo leaf flavonoid group.	Flavonoids	273-282	interleukin 6	Rattus norvegicus	48-52
31060166-16	2019	Conclusion: Bamboo leaf flavonoids can effectively improve depression in diabetic rats through decreasing hippocampal neuronal injury and the release of inflammatory factors, and inhibiting RAGE/P38/NF-kappaB signaling pathway.	Flavonoids	24-34	advanced glycosylation end product-specific receptor	Rattus norvegicus	190-194
31060166-16	2019	Conclusion: Bamboo leaf flavonoids can effectively improve depression in diabetic rats through decreasing hippocampal neuronal injury and the release of inflammatory factors, and inhibiting RAGE/P38/NF-kappaB signaling pathway.	Flavonoids	24-34	mitogen activated protein kinase 14	Rattus norvegicus	195-198
30790579-0	2019	Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships.	Flavonoids	22-32	ATP binding cassette subfamily B member 1	Homo sapiens	36-50
30790579-3	2019	The aim of this study was to investigate the inhibitory effects of 75 flavonoids on P-gp in vitro and in vivo and to illuminate the structure-activity relationships of flavonoids with P-gp.	Flavonoids	168-178	ATP binding cassette subfamily B member 1	Homo sapiens	184-188
30790579-4	2019	Five flavonoids, including tangeretin, sinensetin, isosinensetin, sciadopitysin and oroxylin A exhibited significant inhibition on P-gp in MDR1-MDCKIIcells, which reduced the P-gp-mediated efflux of paraquat and taxol and consequently increased their cell toxicity.	Flavonoids	5-15	ATP binding cassette subfamily B member 1	Homo sapiens	131-135
30790579-4	2019	Five flavonoids, including tangeretin, sinensetin, isosinensetin, sciadopitysin and oroxylin A exhibited significant inhibition on P-gp in MDR1-MDCKIIcells, which reduced the P-gp-mediated efflux of paraquat and taxol and consequently increased their cell toxicity.	Flavonoids	5-15	ATP binding cassette subfamily B member 1	Homo sapiens	175-179
30790579-7	2019	The pharmacophore model suggested the hydrophobic groups in B benzene ring may play a vital role in the potency of flavonoids inhibition on P-gp.	Flavonoids	115-125	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
30892883-3	2019	Certain polyphenol compounds, such as flavonoids, have shown a potent capacity to inhibit VEGF and, consequently, angiogenesis.	Flavonoids	38-48	vascular endothelial growth factor A	Homo sapiens	90-94
31139371-6	2019	The jam was found to contain high concentrations of polyphenolic compounds (137.0 +- 3.2 mg of gallic acid equivalent/100 g), total flavonoids (128.5 +- 23.0 mg of equivalent/100 g), and total anthocyanins (92.5 +- 4.0 mg of cyanidin equivalent/100 g).	Flavonoids	132-142	F11 receptor	Homo sapiens	4-7
30594625-6	2019	Both flavonoids were competitive inhibitors against UGT1A1-mediated NHPN-O-glucuronidation, but were mixed and competitive inhibitors toward UGT1A1-mediated NCHN-O-glucuronidation, respectively.	Flavonoids	5-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-58
30987336-0	2019	Preventive Effect of Anji White Tea Flavonoids on Alcohol-Induced Gastric Injury through Their Antioxidant Effects in Kunming Mice.	Flavonoids	36-46	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	32-35
30987336-1	2019	Anji white tea (Camellia sinensis) is a traditional Chinese tea beverage, which is classified as green tea and contains an abundant amount of flavonoids.	Flavonoids	142-152	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
30987336-1	2019	Anji white tea (Camellia sinensis) is a traditional Chinese tea beverage, which is classified as green tea and contains an abundant amount of flavonoids.	Flavonoids	142-152	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	60-63
30987336-1	2019	Anji white tea (Camellia sinensis) is a traditional Chinese tea beverage, which is classified as green tea and contains an abundant amount of flavonoids.	Flavonoids	142-152	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	60-63
30987336-2	2019	In this study, the preventive effect of Anji white tea flavonoids (AJWTFs) on ethanol/hydrochloric acid-induced gastric injury in mice was evaluated.	Flavonoids	55-65	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	51-54
30987336-5	2019	The Anji white tea flavonoids could also reduce the volume and pH of gastric juice in mice with gastric injury.	Flavonoids	19-29	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	15-18
30987336-10	2019	Anji white tea flavonoids present good antioxidant effect, which allows them to effectively prevent alcoholic gastric injury and be used as biologically active substances with a broad range of applications.	Flavonoids	15-25	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	11-14
30594625-0	2019	Inhibition of UGT1A1 by natural and synthetic flavonoids.	Flavonoids	46-56	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-20
30594625-2	2019	Recent studies demonstrate that some natural flavonoids are potent inhibitors of the human UDP-glucuronosyltransferase 1A1 (UGT1A1), a key enzyme in detoxification of endogenous harmful compounds such as bilirubin.	Flavonoids	45-55	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-122
30594625-2	2019	Recent studies demonstrate that some natural flavonoids are potent inhibitors of the human UDP-glucuronosyltransferase 1A1 (UGT1A1), a key enzyme in detoxification of endogenous harmful compounds such as bilirubin.	Flavonoids	45-55	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-130
30987009-1	2019	Certain antioxidative flavonoids are known to activate nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidants and detoxifying response and is reportedly highly activated in many types of cancers.	Flavonoids	22-32	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
30594625-6	2019	Both flavonoids were competitive inhibitors against UGT1A1-mediated NHPN-O-glucuronidation, but were mixed and competitive inhibitors toward UGT1A1-mediated NCHN-O-glucuronidation, respectively.	Flavonoids	5-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	141-147
30594625-3	2019	In this study, the inhibitory effects of 56 natural and synthetic flavonoids on UGT1A1 were assayed, while the structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated.	Flavonoids	149-159	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	163-169
30594625-5	2019	Further investigation on inhibition kinetics of two strong flavonoid-type UGT1A1 inhibitors, acacetin and kaempferol, yielded interesting results.	Flavonoids	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	59-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	73-79
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	59-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	194-200
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	59-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	194-200
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	179-189	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	73-79
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	179-189	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	194-200
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	179-189	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	194-200
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	73-79
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	194-200
30594625-8	2019	In summary, detailed structure-inhibition relationships of flavonoids as UGT1A1 inhibitors were investigated carefully and the findings shed new light on the interactions between flavonoids and UGT1A1, and will contribute considerably to the development of flavonoid-type drugs without strong UGT1A1 inhibition.	Flavonoids	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	194-200
30723178-9	2019	Under high doses of UV-B radiation, BBX31 promotes the accumulation of UV-protective flavonoids and phenolic compounds.	Flavonoids	85-95	B-box type zinc finger family protein	Arabidopsis thaliana	36-41
32186037-12	2019	CONCLUSION: Scutellaria barbata flavonoids may inhibit TAM activation by blocking the TLR4/MyD88/NF-kappaB signaling pathway.	Flavonoids	32-42	toll like receptor 4	Homo sapiens	86-90
32186037-12	2019	CONCLUSION: Scutellaria barbata flavonoids may inhibit TAM activation by blocking the TLR4/MyD88/NF-kappaB signaling pathway.	Flavonoids	32-42	MYD88 innate immune signal transduction adaptor	Homo sapiens	91-96
30295579-2	2019	In this study, we found that Lotus japonicus Nod factor receptor 5 (LjNFR5) might directly regulate flavonoid biosynthesis during symbiotic interaction with rhizobia.	Flavonoids	100-109	NFR5	Lotus japonicus	68-74
30680817-2	2019	In this study, inhibitory effects of flavonoids baicalein and oroxylin A, a metabolite of baicalein in human body, on CYP1A1 and 1B1 activities were investigated in vitro.	Flavonoids	37-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-132
30502207-2	2019	By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS+ free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE2 and TNF-alpha) and pro-inflammatory cytokines (IL-1beta and IL-6).	Flavonoids	15-25	tumor necrosis factor	Homo sapiens	260-269
30824053-4	2019	Pyruvate, another product of NADP-ME reaction, participates in the synthesis of defense compounds such as flavonoids and lignin, which are involved in stresses tolerance such as mechanical wounding and pathogen invasion.	Flavonoids	106-116	malic enzyme 1	Homo sapiens	29-36
30824053-5	2019	Moreover, NADP-ME provides essential reductive coenzyme NADPH in the biosynthesis of flavonoids and lignin.	Flavonoids	85-95	malic enzyme 1	Homo sapiens	10-17
30502207-2	2019	By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS+ free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE2 and TNF-alpha) and pro-inflammatory cytokines (IL-1beta and IL-6).	Flavonoids	15-25	interleukin 1 beta	Homo sapiens	303-311
30502207-2	2019	By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS+ free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE2 and TNF-alpha) and pro-inflammatory cytokines (IL-1beta and IL-6).	Flavonoids	15-25	interleukin 6	Homo sapiens	316-320
30502207-5	2019	The structure-activity relationships suggested that flavonoids O-glycosides displayed comparable binding affinities to COX-2 compared with flavonoids C-glycosides and could be considered as the main active components.	Flavonoids	52-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
30935135-8	2019	In the presence of flavonoids, Abeta morphology was unchanged from prior to incubation (0 h), in agreement with amyloid beta kinetics analysis using thioflavin-T fluorescence assay.	Flavonoids	19-29	amyloid beta precursor protein	Homo sapiens	31-36
30962863-4	2019	Citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction.	Flavonoids	7-17	insulin	Homo sapiens	72-79
30580173-2	2019	In this study, a qualitative and quantitative detection method for the flavonoids was developed based on the specific interaction between flavonoids and bovine serum albumin (BSA).	Flavonoids	71-81	albumin	Homo sapiens	160-173
30580173-2	2019	In this study, a qualitative and quantitative detection method for the flavonoids was developed based on the specific interaction between flavonoids and bovine serum albumin (BSA).	Flavonoids	138-148	albumin	Homo sapiens	160-173
30917530-8	2019	These findings, for the first time, suggest that the flavonoid metabolite 2,4,6-THBA may mediate its effects through a CDK- and SLC5A8-dependent pathway contributing to the prevention of CRC.	Flavonoids	53-62	solute carrier family 5 member 8	Homo sapiens	128-134
30885129-2	2019	Chalcone synthase (CHS) is a key enzyme in the biosynthesis of flavonoids; it is involved in biosynthesis of all classes of flavonoid compounds.	Flavonoids	63-73	chalcone synthase 2	Triticum aestivum	0-17
30885129-2	2019	Chalcone synthase (CHS) is a key enzyme in the biosynthesis of flavonoids; it is involved in biosynthesis of all classes of flavonoid compounds.	Flavonoids	63-73	chalcone synthase 2	Triticum aestivum	19-22
30885129-2	2019	Chalcone synthase (CHS) is a key enzyme in the biosynthesis of flavonoids; it is involved in biosynthesis of all classes of flavonoid compounds.	Flavonoids	63-72	chalcone synthase 2	Triticum aestivum	0-17
30885129-2	2019	Chalcone synthase (CHS) is a key enzyme in the biosynthesis of flavonoids; it is involved in biosynthesis of all classes of flavonoid compounds.	Flavonoids	63-72	chalcone synthase 2	Triticum aestivum	19-22
30387535-0	2019	Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks.	Flavonoids	0-13	lysine methyltransferase 2A	Homo sapiens	52-55
30396116-5	2019	The IC50 value of 5 for hMAO-A was the lowest amongst all natural flavonoids reported to date, and the potency was 20.2 times higher than that of toloxatone (1.03 microM), a marketed drug.	Flavonoids	66-76	monoamine oxidase A	Homo sapiens	24-30
30899831-0	2019	Homology modeling and docking analysis of ssC1 protein encoded by Cotton leaf curl Multan betasatellite with different plant flavonoids.	Flavonoids	125-135	aquaporin 9	Homo sapiens	42-46
30899831-4	2019	In this study the interaction of ssC1 with selected plant flavonoids has been studied.	Flavonoids	58-68	aquaporin 9	Homo sapiens	33-37
30899831-9	2019	The results obtained from this study clearly indicate that flavonoids are involved in defense against the virus infection, as these molecules binds to the active site of ssC1 protein.	Flavonoids	59-69	aquaporin 9	Homo sapiens	170-174
30841474-6	2019	Experiments on insulin-releasing cell lines, isolated pancreatic islets, and diabetic animal models have shown that flavonoids strengthen the survival processes and insulin secretory capacity of beta cells.	Flavonoids	116-126	insulin	Homo sapiens	15-22
30841474-6	2019	Experiments on insulin-releasing cell lines, isolated pancreatic islets, and diabetic animal models have shown that flavonoids strengthen the survival processes and insulin secretory capacity of beta cells.	Flavonoids	116-126	insulin	Homo sapiens	165-172
30841474-7	2019	The proposed mechanisms by which flavonoids preserve beta cells survival (against cytokines, glucotoxicity, and lipotoxicity) include inhibition of NF-kappaB signaling, activation of PI3K/Akt pathway, inhibition of nitric oxide generation, and decrease of reactive oxygen species levels.	Flavonoids	33-43	AKT serine/threonine kinase 1	Homo sapiens	188-191
30387535-0	2019	Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks.	Flavonoids	0-13	MLLT3 super elongation complex subunit	Homo sapiens	56-59
30387535-6	2019	We show bioflavonoids genistein and quercetin most biochemically similar to etoposide have a strong association with MLL-AF9 bcr translocations, while kaempferol, fisetin, flavone, and myricetin have a weak but consistent association, and other compounds have a minimal association in both embryonic stem (ES) and hematopoietic stem cell (HSC) populations.	Flavonoids	8-21	lysine methyltransferase 2A	Homo sapiens	117-120
30387535-6	2019	We show bioflavonoids genistein and quercetin most biochemically similar to etoposide have a strong association with MLL-AF9 bcr translocations, while kaempferol, fisetin, flavone, and myricetin have a weak but consistent association, and other compounds have a minimal association in both embryonic stem (ES) and hematopoietic stem cell (HSC) populations.	Flavonoids	8-21	MLLT3 super elongation complex subunit	Homo sapiens	121-124
30591531-4	2019	Here we tested whether dual inhibition of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) by flavonoid melafolone improves program death 1 (PD-1) checkpoint blockade therapy through normalizing tumor vasculature and PD-1 ligand (PD-L1) downregulation.	Flavonoids	114-123	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-58
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Flavonoids	77-87	galanin and GMAP prepropeptide	Mus musculus	50-54
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Flavonoids	77-87	nitric oxide synthase 2, inducible	Mus musculus	156-160
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Flavonoids	77-87	catalase	Mus musculus	200-208
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Flavonoids	77-87	catalase	Mus musculus	210-213
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Flavonoids	77-87	nuclear factor, erythroid derived 2, like 2	Mus musculus	280-331
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Flavonoids	77-87	nuclear factor, erythroid derived 2, like 2	Mus musculus	333-337
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Flavonoids	77-87	heme oxygenase 1	Mus musculus	343-359
30641432-5	2019	Additionally five flavonoids inhibited hepatocyte apoptosis through increasing Bcl-2/Bax ratio and suppressing the Caspase family proteins.	Flavonoids	18-28	B cell leukemia/lymphoma 2	Mus musculus	79-84
30641432-5	2019	Additionally five flavonoids inhibited hepatocyte apoptosis through increasing Bcl-2/Bax ratio and suppressing the Caspase family proteins.	Flavonoids	18-28	BCL2-associated X protein	Mus musculus	85-88
32148904-4	2019	The usage of flavonoid for 7  days resulted in stabilization of radical oxidation due to reduction of superoxide dismutase activity, maintenance at the high-level catalase activity, and ceruloplasmin concentration in the rat"s blood plasma with experimental bacterial-immune periodontitis.	Flavonoids	13-22	catalase	Rattus norvegicus	163-171
32148904-4	2019	The usage of flavonoid for 7  days resulted in stabilization of radical oxidation due to reduction of superoxide dismutase activity, maintenance at the high-level catalase activity, and ceruloplasmin concentration in the rat"s blood plasma with experimental bacterial-immune periodontitis.	Flavonoids	13-22	ceruloplasmin	Rattus norvegicus	186-199
30362618-0	2019	Zellweger spectrum disorder patient-derived fibroblasts with the PEX1-Gly843Asp allele recover peroxisome functions in response to flavonoids.	Flavonoids	131-141	peroxisomal biogenesis factor 1	Homo sapiens	65-69
30362618-11	2019	We suggest that diosmetin, in clinical use for chronic venous disease, and related flavonoids warrant further preclinical investigation for the treatment of PEX1-G843D-associated ZSD.	Flavonoids	83-93	peroxisomal biogenesis factor 1	Homo sapiens	157-161
30623852-5	2019	Fatty liver index (FLI) and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly higher in the first tertile (T1) of flavonoid intake compared with the highest tertile (T3: with the highest flavonoid intake) (FLI: 67.1 vs. 36.2, AST: 31.2 VS 26.8 U/L and, ALT: 34.2 vs. 24.2 U/L, respectively; P&lt;.001 for all comparisons).	Flavonoids	157-166	solute carrier family 17 member 5	Homo sapiens	34-60
30623852-5	2019	Fatty liver index (FLI) and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly higher in the first tertile (T1) of flavonoid intake compared with the highest tertile (T3: with the highest flavonoid intake) (FLI: 67.1 vs. 36.2, AST: 31.2 VS 26.8 U/L and, ALT: 34.2 vs. 24.2 U/L, respectively; P&lt;.001 for all comparisons).	Flavonoids	157-166	solute carrier family 17 member 5	Homo sapiens	62-65
30623852-5	2019	Fatty liver index (FLI) and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly higher in the first tertile (T1) of flavonoid intake compared with the highest tertile (T3: with the highest flavonoid intake) (FLI: 67.1 vs. 36.2, AST: 31.2 VS 26.8 U/L and, ALT: 34.2 vs. 24.2 U/L, respectively; P&lt;.001 for all comparisons).	Flavonoids	157-166	glutamic--pyruvic transaminase	Homo sapiens	71-95
30623852-8	2019	Moderation analysis revealed that C-reactive protein (CRP) strongly modulated the impact of flavonoid intake on FLI; participants with higher CRP levels benefited less from flavonoid intake compared with those with lower CRP concentrations.	Flavonoids	92-101	C-reactive protein	Homo sapiens	34-52
30623852-8	2019	Moderation analysis revealed that C-reactive protein (CRP) strongly modulated the impact of flavonoid intake on FLI; participants with higher CRP levels benefited less from flavonoid intake compared with those with lower CRP concentrations.	Flavonoids	92-101	C-reactive protein	Homo sapiens	54-57
30623852-8	2019	Moderation analysis revealed that C-reactive protein (CRP) strongly modulated the impact of flavonoid intake on FLI; participants with higher CRP levels benefited less from flavonoid intake compared with those with lower CRP concentrations.	Flavonoids	173-182	C-reactive protein	Homo sapiens	34-52
30623852-8	2019	Moderation analysis revealed that C-reactive protein (CRP) strongly modulated the impact of flavonoid intake on FLI; participants with higher CRP levels benefited less from flavonoid intake compared with those with lower CRP concentrations.	Flavonoids	173-182	C-reactive protein	Homo sapiens	54-57
30591531-4	2019	Here we tested whether dual inhibition of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) by flavonoid melafolone improves program death 1 (PD-1) checkpoint blockade therapy through normalizing tumor vasculature and PD-1 ligand (PD-L1) downregulation.	Flavonoids	114-123	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65
30591531-4	2019	Here we tested whether dual inhibition of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) by flavonoid melafolone improves program death 1 (PD-1) checkpoint blockade therapy through normalizing tumor vasculature and PD-1 ligand (PD-L1) downregulation.	Flavonoids	114-123	epidermal growth factor receptor	Homo sapiens	71-103
30591531-4	2019	Here we tested whether dual inhibition of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) by flavonoid melafolone improves program death 1 (PD-1) checkpoint blockade therapy through normalizing tumor vasculature and PD-1 ligand (PD-L1) downregulation.	Flavonoids	114-123	epidermal growth factor receptor	Homo sapiens	105-109
29436891-0	2019	Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin.	Flavonoids	89-98	beta-1,3-glucuronyltransferase 2	Homo sapiens	18-22
30488503-8	2019	Usm contained diterpenes and triterpenes different of the other samples and Sil contained triterpenes and flavonoids.	Flavonoids	106-116	STIL centriolar assembly protein	Homo sapiens	76-79
30704824-1	2019	The phenylpropanoid pathway gives rise to lignin, flavonoids, and other metabolites and is regulated by MYB transcription factors.	Flavonoids	50-60	MYB proto-oncogene, transcription factor	Homo sapiens	104-107
30704824-4	2019	The characterized phenylpropanoid R2R3-MYB repressors comprise two phylogenetic clades that act on the lignin and general phenylpropanoid genes, or the flavonoid genes, respectively; anthocyanin R3-MYB repressors form a separate clade.	Flavonoids	152-161	MYB proto-oncogene, transcription factor	Homo sapiens	39-42
29436891-0	2019	Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin.	Flavonoids	89-98	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	27-31
30823377-2	2019	We hypothesized that a flavonoid mixture would have a favorable influence on cell death and the resolution of Mtb infection in THP-1 macrophages and in granulomas derived from both healthy participants and those with type 2 diabetes mellitus (T2DM).	Flavonoids	23-32	GLI family zinc finger 2	Homo sapiens	127-132
30989864-12	2019	The qRT-PCR analysis showed that Mori Folium polysaccharides and flavonoids could inhibit JNK and IRS-1 mRNA expressions,while enhancing PDX-1 mRNA expression.	Flavonoids	65-75	mitogen-activated protein kinase 8	Homo sapiens	90-93
30989864-12	2019	The qRT-PCR analysis showed that Mori Folium polysaccharides and flavonoids could inhibit JNK and IRS-1 mRNA expressions,while enhancing PDX-1 mRNA expression.	Flavonoids	65-75	insulin receptor substrate 1	Homo sapiens	98-103
30989864-12	2019	The qRT-PCR analysis showed that Mori Folium polysaccharides and flavonoids could inhibit JNK and IRS-1 mRNA expressions,while enhancing PDX-1 mRNA expression.	Flavonoids	65-75	pancreatic and duodenal homeobox 1	Homo sapiens	137-142
30989864-13	2019	Western blot analysis displayed that Mori Folium polysaccharides and flavonoids could inhibit p-JNK and IRS-1 protein expressions,while enhancing PDX-1 protein expression.	Flavonoids	69-79	mitogen-activated protein kinase 8	Homo sapiens	96-99
30989864-13	2019	Western blot analysis displayed that Mori Folium polysaccharides and flavonoids could inhibit p-JNK and IRS-1 protein expressions,while enhancing PDX-1 protein expression.	Flavonoids	69-79	insulin receptor substrate 1	Homo sapiens	104-109
30989864-13	2019	Western blot analysis displayed that Mori Folium polysaccharides and flavonoids could inhibit p-JNK and IRS-1 protein expressions,while enhancing PDX-1 protein expression.	Flavonoids	69-79	pancreatic and duodenal homeobox 1	Homo sapiens	146-151
30989864-14	2019	Mori Folium polysaccharides and flavonoids can alleviate insulin resistance in Hep G2 cells,and its mechanism may be the alleviation of insulin resistance by inhibiting JNK signaling pathway.	Flavonoids	32-42	insulin	Homo sapiens	57-64
30989864-14	2019	Mori Folium polysaccharides and flavonoids can alleviate insulin resistance in Hep G2 cells,and its mechanism may be the alleviation of insulin resistance by inhibiting JNK signaling pathway.	Flavonoids	32-42	insulin	Homo sapiens	136-143
30989864-14	2019	Mori Folium polysaccharides and flavonoids can alleviate insulin resistance in Hep G2 cells,and its mechanism may be the alleviation of insulin resistance by inhibiting JNK signaling pathway.	Flavonoids	32-42	mitogen-activated protein kinase 8	Homo sapiens	169-172
30989864-10	2019	01),and the model was relatively stable within 36 h. Mori Folium polysaccharides and flavonoids all alleviated insulin resistance,among which Mori Folium flavonoids had better effect in alleviating Hep G2 insulin resistance(P&lt;0.	Flavonoids	85-95	insulin	Homo sapiens	111-118
30989864-10	2019	01),and the model was relatively stable within 36 h. Mori Folium polysaccharides and flavonoids all alleviated insulin resistance,among which Mori Folium flavonoids had better effect in alleviating Hep G2 insulin resistance(P&lt;0.	Flavonoids	154-164	insulin	Homo sapiens	111-118
30989864-10	2019	01),and the model was relatively stable within 36 h. Mori Folium polysaccharides and flavonoids all alleviated insulin resistance,among which Mori Folium flavonoids had better effect in alleviating Hep G2 insulin resistance(P&lt;0.	Flavonoids	154-164	insulin	Homo sapiens	205-212
30609881-0	2019	Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/beta-Catenin Signaling Activation in 3-Dimensional-Spheroid Cultured Human Dermal Papilla Cells.	Flavonoids	0-9	AKT serine/threonine kinase 1	Homo sapiens	58-61
30652973-0	2019	Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer.	Flavonoids	47-56	prolyl 4-hydroxylase subunit beta	Homo sapiens	10-37
30813510-1	2019	Cocoa bean is a rich source of polyphenols, mainly flavonoids which have a wide range of biological properties.	Flavonoids	51-61	brain expressed, associated with NEDD4, 1	Rattus norvegicus	6-10
30688455-0	2019	Establishment and Use of Human Mouth Epidermal Carcinoma (KB) Cells Overexpressing P-Glycoprotein To Characterize Structure Requirements for Flavonoids Transported by the Efflux Transporter.	Flavonoids	141-151	ATP binding cassette subfamily B member 1	Homo sapiens	83-97
30688455-1	2019	This study was aimed to determine the mechanism for flavonoid poor absorption related to P-glycoprotein (P-gp).	Flavonoids	52-61	ATP binding cassette subfamily B member 1	Homo sapiens	89-103
30688455-1	2019	This study was aimed to determine the mechanism for flavonoid poor absorption related to P-glycoprotein (P-gp).	Flavonoids	52-61	ATP binding cassette subfamily B member 1	Homo sapiens	105-109
30688455-2	2019	The cellular uptake (CU) of 40 flavonoids was investigated in P-gp overexpressing KB/multidrug-resistant (MDR) cells.	Flavonoids	31-41	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
30688455-3	2019	A total of 9 flavonoids, including 5,7,3",4"-tetramethoxyflavone, with a significant ( p &lt; 0.05) CUKBE (2.90 +- 0.146 mumol/g) higher than CUKBP (1.57 +- 0.129 mumol/g) were identified as P-gp substrates.	Flavonoids	13-23	ATP binding cassette subfamily B member 1	Homo sapiens	191-195
30688455-5	2019	A total of 7 of 17 flavonoid substrates stimulated the P-gp efflux of rhodamine 123, and most substrates increased P-gp expression in KB/MDR cells.	Flavonoids	19-28	ATP binding cassette subfamily B member 1	Homo sapiens	55-59
30688455-5	2019	A total of 7 of 17 flavonoid substrates stimulated the P-gp efflux of rhodamine 123, and most substrates increased P-gp expression in KB/MDR cells.	Flavonoids	19-28	ATP binding cassette subfamily B member 1	Homo sapiens	115-119
30688455-7	2019	A structure-affinity relationship exhibited that 3-OH, 5-OH, 3"-OCH3, and 4"-OCH3 are crucial for flavonoids binding to P-gp.	Flavonoids	98-108	ATP binding cassette subfamily B member 1	Homo sapiens	120-124
30698432-0	2019	Prenylated Flavonoids from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on the Expression of Inflammatory Mediators and Proprotein Convertase Subtilisin/Kexin Type 9.	Flavonoids	11-21	proprotein convertase subtilisin/kexin type 9	Homo sapiens	139-184
30694659-4	2019	Herein, we report that myricetin and some natural flavonoids are able to inhibit hFEN1.	Flavonoids	50-60	flap structure-specific endonuclease 1	Homo sapiens	81-86
30624931-7	2019	Finally, we propose that dietary flavonoids may inhibit IP6K activity in cells that line the gastrointestinal tract.	Flavonoids	33-43	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	56-60
30624931-3	2019	Herein, we demonstrate that both kinases are inhibited by quercetin and 16 related flavonoids; IP6K is the preferred target.	Flavonoids	83-93	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	95-99
30729071-5	2019	The selected flavonoids were also tested for their aldose reductase (AR) inhibition (experimental and in silico).	Flavonoids	13-23	aldo-keto reductase family 1 member B	Homo sapiens	51-67
30628617-1	2019	Expression of cucumber (Cucumis sativus) genes encoding the phenylpropanoid and flavonoid biosynthetic enzymes phenylalanine ammonia lyase (PAL), cinnamic acid 4-hydroxylase (C4H), and chalcone synthase (CHS), was studied under control light conditions (photosynthetically active radiation, PAR) in root, stem, and leaf.	Flavonoids	80-89	trans-cinnamate 4-monooxygenase	Cucumis sativus	146-173
30729071-5	2019	The selected flavonoids were also tested for their aldose reductase (AR) inhibition (experimental and in silico).	Flavonoids	13-23	aldo-keto reductase family 1 member B	Homo sapiens	69-71
30729071-6	2019	The molecular dynamics simulation results shed light on mechanistic details of flavonoid induced AR inhibition.	Flavonoids	79-88	aldo-keto reductase family 1 member B	Homo sapiens	97-99
30293202-2	2019	Flavonol synthase (FLS), anthocyanidin synthase (ANS), and flavanone 3beta-hydroxylase belong to the 2-oxoglutarate-dependent (2ODD) oxygenase family, and each performs crucial functions in the biosynthesis of flavonoids.	Flavonoids	210-220	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	0-17
30853999-2	2019	Antiviral activity of the flavonoids was assessed by analyzing HIV-1 p24 core protein levels in the supernatants of HIV-1 infected MT-4 and MT-2 cell cultures.	Flavonoids	26-36	metallothionein 4	Homo sapiens	131-135
30853999-2	2019	Antiviral activity of the flavonoids was assessed by analyzing HIV-1 p24 core protein levels in the supernatants of HIV-1 infected MT-4 and MT-2 cell cultures.	Flavonoids	26-36	metallothionein 2A	Homo sapiens	140-144
30717018-6	2019	In addition, flavonoid biosynthetic proteins, such as cinnamate 4-hydroxylase, chalcone isomerase, chalcone synthase, isoflavone synthase and isoflavone reductase, were also modulated in response to ABA treatment.	Flavonoids	13-22	eugenol synthase 1	Glycine max	99-162
30530257-2	2019	Since every person harbors a unique set of gut bacteria, we investigated the influence of the gut microbiota"s interpersonal heterogeneity on the production and bioavailability of flavonoid metabolites that may interfere with the misfolding of alpha (alpha)-synuclein, a process that plays a central role in Parkinson"s disease and other alpha-synucleinopathies.	Flavonoids	180-189	synuclein, alpha	Mus musculus	250-267
30203888-10	2019	The results of the present study suggest that treatment with quercetin, a common flavonoid in plants, is potentially a useful strategy for the treatment of CRCs carrying KRAS mutations.	Flavonoids	81-90	KRAS proto-oncogene, GTPase	Homo sapiens	170-174
30483725-8	2019	The mechanism underlying the anti-inflammatory effects of isorhamnetin was subsequently evaluated; this flavonoid inhibited the nuclear factor (NF)-kappaB signaling pathway by disrupting degradation and phosphorylation of inhibitor kappaB-alpha in the cytoplasm and blocking translocation of NF-kappaB p65 into the nucleus.	Flavonoids	104-113	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	292-301
30483725-8	2019	The mechanism underlying the anti-inflammatory effects of isorhamnetin was subsequently evaluated; this flavonoid inhibited the nuclear factor (NF)-kappaB signaling pathway by disrupting degradation and phosphorylation of inhibitor kappaB-alpha in the cytoplasm and blocking translocation of NF-kappaB p65 into the nucleus.	Flavonoids	104-113	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	302-305
31084404-3	2019	The focus of this study is on the interaction of hesperidin, a natural flavonoid with Group IB, IIA, and V and X isozymes of sPLA2.	Flavonoids	71-80	phospholipase A2 group IIA	Homo sapiens	125-130
30293202-2	2019	Flavonol synthase (FLS), anthocyanidin synthase (ANS), and flavanone 3beta-hydroxylase belong to the 2-oxoglutarate-dependent (2ODD) oxygenase family, and each performs crucial functions in the biosynthesis of flavonoids.	Flavonoids	210-220	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	19-22
30668393-11	2019	CONCLUSION: The lignan PRO and the flavonoid MFO are two novel Nrf2 activators protecting tissues against oxidative insults, and these two constituents support the application of cinnamon as an agent against oxidative stress related diseases.	Flavonoids	35-44	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
30293202-2	2019	Flavonol synthase (FLS), anthocyanidin synthase (ANS), and flavanone 3beta-hydroxylase belong to the 2-oxoglutarate-dependent (2ODD) oxygenase family, and each performs crucial functions in the biosynthesis of flavonoids.	Flavonoids	210-220	leucoanthocyanidin dioxygenase-like	Nicotiana tabacum	25-47
30668394-7	2019	CONCLUSION: QU and KA increased the intestinal absorption of IS in TFH by regulating the activity and expression of MRP2, which provides useful information for the investigation of the transporter-mediated interaction of flavonoid components in herbal extracts.	Flavonoids	221-230	ATP binding cassette subfamily C member 2	Rattus norvegicus	116-120
30766532-0	2019	Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.	Flavonoids	28-38	CD4 molecule	Homo sapiens	64-67
29310511-12	2019	These results indicate that CYP2A6 and other human P450s have important roles in metabolizing flavone and flavanone, two unsubstituted flavonoids, present in dietary foods.	Flavonoids	135-145	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	28-34
30766532-0	2019	Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.	Flavonoids	28-38	mechanistic target of rapamycin kinase	Homo sapiens	109-113
30766532-5	2019	In the current review, we assessed the effects of flavonoids on the immune system and then their impact on the mTOR pathway.	Flavonoids	50-60	mechanistic target of rapamycin kinase	Homo sapiens	111-115
30766532-6	2019	Flavonoids can suppress mTOR activity and are consequently able to induce the T regulatory subset.	Flavonoids	0-10	mechanistic target of rapamycin kinase	Homo sapiens	24-28
30663749-0	2019	New flavonoids from the Saudi Arabian plant Retama raetam which stimulates secretion of insulin and inhibits alpha-glucosidase.	Flavonoids	4-14	sucrase isomaltase (alpha-glucosidase)	Mus musculus	109-126
30704023-1	2019	The aim of this study was to analyze the binding interactions between a common antihypertensive drug (amlodipine besylate-AML) and the widely distributed plant flavonoid quercetin (Q), in the presence of human serum albumin (HSA).	Flavonoids	160-169	albumin	Homo sapiens	210-223
30309520-5	2019	The activities of caspases 3/7 were also significantly reduced significantly in HTR-8/SVneo cells pre-treated with flavonoids.	Flavonoids	115-125	caspase 3	Homo sapiens	18-30
30678358-4	2019	Differently substituted flavonoids have been prepared and investigated as MAO-A and MAO-B inhibitors.	Flavonoids	24-34	monoamine oxidase A	Homo sapiens	74-79
30589259-3	2019	In order to gain insight into the mechanism underlying the rare changes in the color of solutions of complexes between flavonoids, the structures of the MGR monomer and the complexes in aqueous solutions and their photochemical properties were investigated by computational methods.	Flavonoids	119-129	MGR6	Homo sapiens	153-156
30678358-4	2019	Differently substituted flavonoids have been prepared and investigated as MAO-A and MAO-B inhibitors.	Flavonoids	24-34	monoamine oxidase B	Homo sapiens	84-89
30463907-0	2019	Total flavonoids extracted from Nervilia Fordii function in polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway.	Flavonoids	6-16	interleukin 6	Rattus norvegicus	94-98
30679715-0	2019	Transport of Anthocyanins and other Flavonoids by the Arabidopsis ATP-Binding Cassette Transporter AtABCC2.	Flavonoids	36-46	multidrug resistance-associated protein 2	Arabidopsis thaliana	99-106
30679715-9	2019	In conclusion, we suggest that AtABCC2 along with possibly other ABCC proteins are involved in the vacuolar transport of anthocyanins and other flavonoids in the vegetative tissue of Arabidopsis.	Flavonoids	144-154	multidrug resistance-associated protein 2	Arabidopsis thaliana	31-38
30463907-0	2019	Total flavonoids extracted from Nervilia Fordii function in polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway.	Flavonoids	6-16	Janus kinase 2	Rattus norvegicus	108-112
30463907-0	2019	Total flavonoids extracted from Nervilia Fordii function in polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway.	Flavonoids	6-16	signal transducer and activator of transcription 3	Rattus norvegicus	113-118
30463907-7	2019	We explored that total flavonoids obviously increased the serum levels of follicle-stimulating hormone (FSH), and sharply decreased the serum levels of luteinizing hormone (LH), testosterone (T) and insulin (INS) in the PCOS-IR rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and partially down-regulating the suppressor of cytokine signaling 3 (SOCS3) expression in ovaries of PCOS rats.	Flavonoids	23-33	Janus kinase 2	Rattus norvegicus	273-277
30463907-7	2019	We explored that total flavonoids obviously increased the serum levels of follicle-stimulating hormone (FSH), and sharply decreased the serum levels of luteinizing hormone (LH), testosterone (T) and insulin (INS) in the PCOS-IR rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and partially down-regulating the suppressor of cytokine signaling 3 (SOCS3) expression in ovaries of PCOS rats.	Flavonoids	23-33	signal transducer and activator of transcription 3	Rattus norvegicus	278-283
30463907-7	2019	We explored that total flavonoids obviously increased the serum levels of follicle-stimulating hormone (FSH), and sharply decreased the serum levels of luteinizing hormone (LH), testosterone (T) and insulin (INS) in the PCOS-IR rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and partially down-regulating the suppressor of cytokine signaling 3 (SOCS3) expression in ovaries of PCOS rats.	Flavonoids	23-33	interleukin 6	Rattus norvegicus	321-325
30463907-7	2019	We explored that total flavonoids obviously increased the serum levels of follicle-stimulating hormone (FSH), and sharply decreased the serum levels of luteinizing hormone (LH), testosterone (T) and insulin (INS) in the PCOS-IR rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and partially down-regulating the suppressor of cytokine signaling 3 (SOCS3) expression in ovaries of PCOS rats.	Flavonoids	23-33	suppressor of cytokine signaling 3	Rattus norvegicus	371-405
30463907-7	2019	We explored that total flavonoids obviously increased the serum levels of follicle-stimulating hormone (FSH), and sharply decreased the serum levels of luteinizing hormone (LH), testosterone (T) and insulin (INS) in the PCOS-IR rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and partially down-regulating the suppressor of cytokine signaling 3 (SOCS3) expression in ovaries of PCOS rats.	Flavonoids	23-33	suppressor of cytokine signaling 3	Rattus norvegicus	407-412
30463907-8	2019	The effect of total flavonoids on estrous cycles, serum levels of FSH, LH, T and INS were partially attenuated by IL-6 in PCOS rat model.	Flavonoids	20-30	interleukin 6	Rattus norvegicus	114-118
30463907-9	2019	Moreover, IL-6 significantly reversed the effect of total flavonoids on the phosphorylation of JAK2/STAT3, the expression of IL-6 and SOCS3 in ovaries of PCOS rats.	Flavonoids	58-68	interleukin 6	Rattus norvegicus	10-14
30463907-9	2019	Moreover, IL-6 significantly reversed the effect of total flavonoids on the phosphorylation of JAK2/STAT3, the expression of IL-6 and SOCS3 in ovaries of PCOS rats.	Flavonoids	58-68	Janus kinase 2	Rattus norvegicus	95-99
30463907-9	2019	Moreover, IL-6 significantly reversed the effect of total flavonoids on the phosphorylation of JAK2/STAT3, the expression of IL-6 and SOCS3 in ovaries of PCOS rats.	Flavonoids	58-68	signal transducer and activator of transcription 3	Rattus norvegicus	100-105
30463907-9	2019	Moreover, IL-6 significantly reversed the effect of total flavonoids on the phosphorylation of JAK2/STAT3, the expression of IL-6 and SOCS3 in ovaries of PCOS rats.	Flavonoids	58-68	interleukin 6	Rattus norvegicus	125-129
30463907-9	2019	Moreover, IL-6 significantly reversed the effect of total flavonoids on the phosphorylation of JAK2/STAT3, the expression of IL-6 and SOCS3 in ovaries of PCOS rats.	Flavonoids	58-68	suppressor of cytokine signaling 3	Rattus norvegicus	134-139
30463907-10	2019	Total flavonoids extracted from Nervilia Fordii might induce the expression of IL-6 in ovary and act as a potential therapeutic drug for the treatment of PCOS.	Flavonoids	6-16	interleukin 6	Rattus norvegicus	79-83
30966772-0	2019	Luteolin: A Natural Flavonoid Enhances the Survival of HUVECs against Oxidative Stress by Modulating AMPK/PKC Pathway.	Flavonoids	20-29	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	101-105
30551400-3	2019	Furthermore, flavonoids have been implicated in a) neuronal proliferation and survival, by acting on a variety of cellular signalling cascades, including the ERK/CREB/BDNF and PI3K/Akt pathway, b) oxidative stress reduction and c) relief from Alzheimer"s disease-type symptoms.	Flavonoids	13-23	mitogen-activated protein kinase 1	Homo sapiens	158-161
31334043-2	2019	In recent time, the interaction of flavonoid-metal complexes with serum albumin (SA) has widely been studied since the complexation poses a significant impact on biological activities.	Flavonoids	35-44	albumin	Homo sapiens	66-79
30551400-3	2019	Furthermore, flavonoids have been implicated in a) neuronal proliferation and survival, by acting on a variety of cellular signalling cascades, including the ERK/CREB/BDNF and PI3K/Akt pathway, b) oxidative stress reduction and c) relief from Alzheimer"s disease-type symptoms.	Flavonoids	13-23	cAMP responsive element binding protein 1	Homo sapiens	162-166
30551400-3	2019	Furthermore, flavonoids have been implicated in a) neuronal proliferation and survival, by acting on a variety of cellular signalling cascades, including the ERK/CREB/BDNF and PI3K/Akt pathway, b) oxidative stress reduction and c) relief from Alzheimer"s disease-type symptoms.	Flavonoids	13-23	brain derived neurotrophic factor	Homo sapiens	167-171
30551400-3	2019	Furthermore, flavonoids have been implicated in a) neuronal proliferation and survival, by acting on a variety of cellular signalling cascades, including the ERK/CREB/BDNF and PI3K/Akt pathway, b) oxidative stress reduction and c) relief from Alzheimer"s disease-type symptoms.	Flavonoids	13-23	AKT serine/threonine kinase 1	Homo sapiens	181-184
30277144-3	2019	Naturally occurring flavonoids as benzopyrone derivatives were recognized as a class of nontoxic inhibitors of P-gp.	Flavonoids	20-30	phosphoglycolate phosphatase	Homo sapiens	111-115
29781252-0	2019	Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoid.	Flavonoids	72-81	acid-sensing (proton-gated) ion channel 3	Mus musculus	32-58
29781252-3	2019	RESULTS: We identified a natural flavonoid compound, (-)-epigallocatechin gallate (EGCG, compound 11), that acts as a potent inhibitor for the ASIC3 channel in an isoform-specific way.	Flavonoids	33-42	acid-sensing (proton-gated) ion channel 3	Mus musculus	143-148
29667548-5	2019	Flavonoids have been reported to reduce platelet activity by attenuating agonist-induced GPIIb/IIIa receptor activation, mobilization of intracellular free Ca2+, granule exocytosis, as well as activation of different signaling molecules such as mitogen-activated protein kinases or phospholipases.	Flavonoids	0-10	integrin subunit alpha 2b	Homo sapiens	89-94
31149994-1	2019	AIM: The study was aimed at assessing efficacy and safety of using a micronized purified flavonoid fraction in the perioperative period in patients scheduled for endovascular surgical intervention for CEAP clinical class C2 lower limb varicose veins.	Flavonoids	89-98	biogenesis of lysosomal organelles complex 1 subunit 2	Homo sapiens	201-205
31149994-9	2019	CONCLUSION: Prescription of the micronized purified flavonoid fraction in the perioperative period ensures a significant decrease in the incidence of typical adverse events developing after endovascular surgical treatment for CEAP clinical class C2 varicose veins and may be recommended for real clinical practice.	Flavonoids	52-61	biogenesis of lysosomal organelles complex 1 subunit 2	Homo sapiens	226-230
30351529-9	2019	S. lentiscifolius bark extract has antioxidant activity and inhibitory effect on HSR probably due to the presence of polyphenols as the flavonoids quercetin and kaempferol.	Flavonoids	136-146	HSR	Homo sapiens	81-84
30277144-4	2019	The recent advent of synthetic flavonoid dimer FD18, as a potent P-gp modulator in reversing multidrug resistance both in vitro and in vivo, specifically targeted the pseudodimeric structure of the drug transporter and represented a new generation of inhibitors with high transporter binding affinity and low toxicity.	Flavonoids	31-40	phosphoglycolate phosphatase	Homo sapiens	65-69
30569843-6	2019	There are strong evidences, in in vitro and animal experimental models, that some flavonoids induce vasodilator effects, improve endothelial dysfunction and insulin resistance, exert platelet antiaggregant and atheroprotective effects, and reduce blood pressure.	Flavonoids	82-92	insulin	Homo sapiens	157-164
30277144-5	2019	This review concerned the recent updates on the structure-activity relationships of flavonoids as P-gp inhibitors, the molecular mechanisms of their action and their ability to overcome P-gp-mediated MDR in preclinical studies.	Flavonoids	84-94	phosphoglycolate phosphatase	Homo sapiens	98-102
30277144-5	2019	This review concerned the recent updates on the structure-activity relationships of flavonoids as P-gp inhibitors, the molecular mechanisms of their action and their ability to overcome P-gp-mediated MDR in preclinical studies.	Flavonoids	84-94	phosphoglycolate phosphatase	Homo sapiens	186-190
30999791-4	2019	Here, we further found that the flavonoid accumulation was significantly affected by blocking the activities of alpha-KGDH and GABA transaminase as well as applying exogenous GABA, coupled with the changes of endogenous GABA contents.	Flavonoids	32-41	4-aminobutyrate aminotransferase	Homo sapiens	127-144
31721711-5	2019	A dataset of reported compounds against CYP1 belongs to 10 different classes (alkaloids, coumarins, flavonoids, natural compounds, synthetic inhibitors, drugs, MBI"s, PAHs, naphthoquinone and stilbenoids) was retrieved and utilized for the comparative molecular docking analyses followed by pharmacophore modeling.	Flavonoids	100-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-44
30727927-3	2019	Flavonoids have inhibitory effects on the acute and chronic inflammatory responses caused by TNF-alpha.	Flavonoids	0-10	tumor necrosis factor	Mus musculus	93-102
30584780-5	2019	Among the different chemical classes of natural NQO1 inhibitors are coumarins, flavonoids, and triterpenoids.	Flavonoids	79-89	NAD(P)H quinone dehydrogenase 1	Homo sapiens	48-52
30447303-2	2019	This compound had different pharmacological effects and presented a chemical structure like the flavonoid eriodyctiol that exhibited antinociceptive effects by TRPV1 antagonism.	Flavonoids	96-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	160-165
30661409-1	2019	Quercetin, an antioxidant flavonoid, has been known that it can induce the cell cycle arrest and apoptosis of hepatocellular carcinoma (HCC) cells by the stabilization or induction of p53.	Flavonoids	26-35	tumor protein p53	Homo sapiens	184-187
31400269-0	2019	Dietary Flavonoids Interaction with CREB-BDNF Pathway: An Unconventional Approach for Comprehensive Management of Epilepsy.	Flavonoids	8-18	cAMP responsive element binding protein 1	Homo sapiens	36-40
31400269-0	2019	Dietary Flavonoids Interaction with CREB-BDNF Pathway: An Unconventional Approach for Comprehensive Management of Epilepsy.	Flavonoids	8-18	brain derived neurotrophic factor	Homo sapiens	41-45
31400269-5	2019	Flavonoids are the polyphenolic compounds which lead to phosphorylation of CREB in the hippocampus, followed by increase in extracellular signal regulated kinase (ERK) and BDNF.	Flavonoids	0-10	cAMP responsive element binding protein 1	Homo sapiens	75-79
31400269-5	2019	Flavonoids are the polyphenolic compounds which lead to phosphorylation of CREB in the hippocampus, followed by increase in extracellular signal regulated kinase (ERK) and BDNF.	Flavonoids	0-10	mitogen-activated protein kinase 1	Homo sapiens	124-161
31400269-5	2019	Flavonoids are the polyphenolic compounds which lead to phosphorylation of CREB in the hippocampus, followed by increase in extracellular signal regulated kinase (ERK) and BDNF.	Flavonoids	0-10	mitogen-activated protein kinase 1	Homo sapiens	163-166
31400269-5	2019	Flavonoids are the polyphenolic compounds which lead to phosphorylation of CREB in the hippocampus, followed by increase in extracellular signal regulated kinase (ERK) and BDNF.	Flavonoids	0-10	brain derived neurotrophic factor	Homo sapiens	172-176
31400269-6	2019	Several members of flavonoid family have also showed suppression of epileptic seizures via interaction with CREB/BDNF pathway.	Flavonoids	19-28	cAMP responsive element binding protein 1	Homo sapiens	108-112
31400269-6	2019	Several members of flavonoid family have also showed suppression of epileptic seizures via interaction with CREB/BDNF pathway.	Flavonoids	19-28	brain derived neurotrophic factor	Homo sapiens	113-117
31400269-8	2019	Multiple studies have also supported the beneficial effects of flavonoids in cognitive and memory impairments by upregulation of CREB-BDNF pathway.	Flavonoids	63-73	cAMP responsive element binding protein 1	Homo sapiens	129-133
31400269-8	2019	Multiple studies have also supported the beneficial effects of flavonoids in cognitive and memory impairments by upregulation of CREB-BDNF pathway.	Flavonoids	63-73	brain derived neurotrophic factor	Homo sapiens	134-138
31400269-9	2019	The current review is an attempt to collate the available preclinical and clinical studies to establish the therapeutic potential of various dietary flavonoids in comprehensive management of epilepsy with relation to CREB-BDNF pathway.	Flavonoids	149-159	cAMP responsive element binding protein 1	Homo sapiens	217-221
31400269-9	2019	The current review is an attempt to collate the available preclinical and clinical studies to establish the therapeutic potential of various dietary flavonoids in comprehensive management of epilepsy with relation to CREB-BDNF pathway.	Flavonoids	149-159	brain derived neurotrophic factor	Homo sapiens	222-226
30488802-5	2019	Furthermore, food antigens (for example, tryptophan derivatives, flavonoids and byphenils) bind the aryl hydrocarbon receptor on innate lymphoid cells (ILCs), thus promoting the development of postnatal lymphoid tissues.	Flavonoids	65-75	aryl hydrocarbon receptor	Homo sapiens	100-125
30558728-1	2019	Plants respond to abiotic UV-B stress with enhanced expression of genes for flavonoid production, especially the key-enzyme chalcone synthase (CHS).	Flavonoids	76-85	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	124-141
31453129-9	2019	In vitro experiments, flavonoids contained in these kampo medicines, inhibited GSK-3beta activity in concentration-dependent manners.	Flavonoids	22-32	glycogen synthase kinase 3 beta	Mus musculus	79-88
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	nuclear factor kappa B subunit 1	Homo sapiens	69-78
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	NLR family pyrin domain containing 3	Homo sapiens	84-89
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	interleukin 1 beta	Homo sapiens	156-164
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	interleukin 2	Homo sapiens	166-170
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	interleukin 6	Homo sapiens	172-176
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	tumor necrosis factor	Homo sapiens	178-187
31814545-5	2019	Some flavonoids exert anti-inflammatory effects through: Blockade of NF-kappaB, and NLRP3 inflammasome, inhibition of pro-inflammatory cytokine production, IL-1beta, IL-2, IL-6, TNF-alpha, IL-17A, down regulation of chemokines, and reduction of reactive oxygen and nitrogen species.	Flavonoids	5-15	interleukin 17A	Homo sapiens	189-195
30602686-2	2018	Previously it has been demonstrated that prenylation of flavonoids allows the discovery of new compounds with improved antitumor activity through the activation of caspase-7 activity.	Flavonoids	56-66	caspase 7	Homo sapiens	164-173
30591695-6	2018	Expression analysis of flavonoid biosynthesis structural genes revealed that chalcone synthase (CHS), dihydroflavonol 4-reductase (DFR), leucoanthocyanidin reductase (LAR) and UDP glucose flavonoid 3-O-glucosyl transferase (UFGT) were strongly down-regulated in the VvMYBC2L2-overexpressed tobacco.	Flavonoids	23-32	dihydroflavonol-4-reductase	Nicotiana tabacum	102-129
30591695-6	2018	Expression analysis of flavonoid biosynthesis structural genes revealed that chalcone synthase (CHS), dihydroflavonol 4-reductase (DFR), leucoanthocyanidin reductase (LAR) and UDP glucose flavonoid 3-O-glucosyl transferase (UFGT) were strongly down-regulated in the VvMYBC2L2-overexpressed tobacco.	Flavonoids	23-32	dihydroflavonol-4-reductase	Nicotiana tabacum	131-134
30361436-0	2018	Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of glucose transporter 1 (GLUT1)-mediated sugar uptake.	Flavonoids	23-33	solute carrier family 2 member 1	Homo sapiens	94-115
30591695-6	2018	Expression analysis of flavonoid biosynthesis structural genes revealed that chalcone synthase (CHS), dihydroflavonol 4-reductase (DFR), leucoanthocyanidin reductase (LAR) and UDP glucose flavonoid 3-O-glucosyl transferase (UFGT) were strongly down-regulated in the VvMYBC2L2-overexpressed tobacco.	Flavonoids	23-32	transcription repressor MYB6-like	Vitis vinifera	266-275
30585235-0	2018	Influence of Bovine Serum Albumin-Flavonoid Interaction on the Antioxidant Activity of Dietary Flavonoids: New Evidence from Electrochemical Quantification.	Flavonoids	34-43	albumin	Homo sapiens	20-33
30585235-0	2018	Influence of Bovine Serum Albumin-Flavonoid Interaction on the Antioxidant Activity of Dietary Flavonoids: New Evidence from Electrochemical Quantification.	Flavonoids	95-105	albumin	Homo sapiens	20-33
30585235-5	2018	All the flavonoids show a decreasing in the antioxidant activity detected by CRAC assay, indicting a "masking effect" of bovine serum albumin (BSA)-flavonoid interaction.	Flavonoids	8-17	albumin	Homo sapiens	128-141
30586938-4	2018	Results showed that when the steam pressure was 2.0 MPa, duration was 88 s and a sieving mesh size was 60, the total flavonoids content in seabuckthorm reached a maximum of 24.74 +- 0.71 mg CAE/g, an increase of 246% compared with that without steam explosion treatment (7.14 +- 0.42 mg CAE/g).	Flavonoids	117-127	gap junction protein alpha 8	Homo sapiens	190-193
30361436-6	2018	Docking studies suggest that only one flavonoid can bind to GLUT1 at any instant, but sugar transport and ligand-binding studies indicate that human erythrocyte GLUT1 can bind at least two flavonoid molecules simultaneously.	Flavonoids	189-198	solute carrier family 2 member 1	Homo sapiens	161-166
30361436-0	2018	Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of glucose transporter 1 (GLUT1)-mediated sugar uptake.	Flavonoids	23-33	solute carrier family 2 member 1	Homo sapiens	117-122
30361436-2	2018	Some studies, however, show that flavonoids inhibit GLUT1-mediated, facilitative glucose transport, raising the possibility that their interaction with GLUT1 and subsequent downstream effects on carbohydrate metabolism may also impact health.	Flavonoids	33-43	solute carrier family 2 member 1	Homo sapiens	52-57
30361436-2	2018	Some studies, however, show that flavonoids inhibit GLUT1-mediated, facilitative glucose transport, raising the possibility that their interaction with GLUT1 and subsequent downstream effects on carbohydrate metabolism may also impact health.	Flavonoids	33-43	solute carrier family 2 member 1	Homo sapiens	152-157
30361436-3	2018	The present study explores the structure-function relationships of flavonoid-GLUT1 interactions.	Flavonoids	67-76	solute carrier family 2 member 1	Homo sapiens	77-82
30361436-6	2018	Docking studies suggest that only one flavonoid can bind to GLUT1 at any instant, but sugar transport and ligand-binding studies indicate that human erythrocyte GLUT1 can bind at least two flavonoid molecules simultaneously.	Flavonoids	38-47	solute carrier family 2 member 1	Homo sapiens	60-65
30267791-0	2018	MIA-QSAR based model for bioactivity prediction of flavonoid derivatives as acetylcholinesterase inhibitors.	Flavonoids	51-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-96
30448188-2	2018	Hence, phytochemicals or dietary flavonoids, if identified as CYP1A1 inhibitors, may help in preventing PAH-mediated carcinogenesis and breast cancer.	Flavonoids	33-43	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	62-68
30267791-3	2018	This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE).	Flavonoids	81-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	207-238
30267791-3	2018	This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE).	Flavonoids	81-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	240-244
30509179-3	2018	Chalcone synthase (CHS) is the plant-specific type III polyketide synthase that catalyzes the first committed step in (iso)flavonoid biosynthesis in plants.	Flavonoids	123-132	chalcone synthase	Glycine max	0-17
30411897-4	2018	Anthocyanin- and flavonoid-rich fractions shared similar advantages in preventing the expression of senescence-associated beta-galactosidase (34.8% +- 11.1% and 32.2% +- 9.7% of aged cells, respectively) and overexpression of vascular endothelial growth factor (51.8 +- 3.5 and 54.1 +- 6.5 pg/mL, respectively).	Flavonoids	17-26	galactosidase beta 1	Homo sapiens	122-140
30509179-3	2018	Chalcone synthase (CHS) is the plant-specific type III polyketide synthase that catalyzes the first committed step in (iso)flavonoid biosynthesis in plants.	Flavonoids	123-132	chalcone synthase	Glycine max	19-22
30130649-0	2018	Tyrosinase inhibition by some flavonoids: Inhibitory activity, mechanism by in vitro and in silico studies.	Flavonoids	30-40	tyrosinase	Homo sapiens	0-10
28770537-8	2018	Moreover, the expressions of mature forms of sterol regulatory element-binding proteins (nuclear form of srebps, n-SREBPs) and 3-hydroxy-3-methylglutaryl coenzyme reductase (HMGCR) involved in lipid metabolism, were suppressed in the Fs-treated groups.	Flavonoids	234-236	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	127-172
28770537-8	2018	Moreover, the expressions of mature forms of sterol regulatory element-binding proteins (nuclear form of srebps, n-SREBPs) and 3-hydroxy-3-methylglutaryl coenzyme reductase (HMGCR) involved in lipid metabolism, were suppressed in the Fs-treated groups.	Flavonoids	234-236	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	174-179
30176084-2	2018	Early studies have demonstrated that flavonoid biosynthesis is transcriptionally regulated, often by a MYB, bHLH, and WDR transcription factor complex.	Flavonoids	37-46	MYB proto-oncogene, transcription factor	Homo sapiens	103-106
30671409-0	2018	Flavonoids Fraction of Mespilus Germanica Alleviates Insulin Resistance in Metabolic Syndrome Model of Ovariectomized Rats via Reduction in Tumor Necrosis Factor-alpha.	Flavonoids	0-10	tumor necrosis factor	Rattus norvegicus	140-167
30671409-7	2018	Results: Treatment with flavonoids fraction of MGL significantly decreased serum level of insulin (P = 0.011), glucose (P = 0.024), TNF-alpha (P = 0.010), also MetS Z score (P = 0.020) and homeostasis model assessment of insulin resistance (P = 0.007).	Flavonoids	24-34	tumor necrosis factor	Rattus norvegicus	132-141
30671409-9	2018	Conclusions: Flavonoids of MGL attenuates some of the MetS components possibly via reduction in TNF-alpha inflammatory cytokine.	Flavonoids	13-23	tumor necrosis factor	Rattus norvegicus	96-105
30323153-9	2018	Huangqin flavonoid extraction also increased immunoreactivity and expression levels of brain-derived neurotrophic factor and neurofilament protein, and reduced immunoreactivity and expression levels of CD11b and glial fibrillary acidic protein, in the injured spinal cord.	Flavonoids	9-18	brain-derived neurotrophic factor	Rattus norvegicus	87-120
30323153-9	2018	Huangqin flavonoid extraction also increased immunoreactivity and expression levels of brain-derived neurotrophic factor and neurofilament protein, and reduced immunoreactivity and expression levels of CD11b and glial fibrillary acidic protein, in the injured spinal cord.	Flavonoids	9-18	integrin subunit alpha M	Rattus norvegicus	202-207
30323153-10	2018	Overall, these data suggest that Huangqin flavonoid extraction can promote recovery of spinal cord injury by inducing brain-derived neurotrophic factor and neurofilament protein expression, reducing microglia activation and regulating reactive astrocytes.	Flavonoids	42-51	brain-derived neurotrophic factor	Rattus norvegicus	118-151
29981254-0	2018	TRANSPARENT TESTA 4-mediated flavonoids negatively affect embryonic fatty acid biosynthesis in Arabidopsis.	Flavonoids	29-39	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-19
29981254-2	2018	TRANSPARENT TESTA 4 (TT4) acts at the first step of flavonoid biosynthesis, and the loss of TT4 function causes a lack of flavonoid.	Flavonoids	52-61	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-19
29981254-2	2018	TRANSPARENT TESTA 4 (TT4) acts at the first step of flavonoid biosynthesis, and the loss of TT4 function causes a lack of flavonoid.	Flavonoids	52-61	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	21-24
29981254-2	2018	TRANSPARENT TESTA 4 (TT4) acts at the first step of flavonoid biosynthesis, and the loss of TT4 function causes a lack of flavonoid.	Flavonoids	122-131	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-19
29981254-2	2018	TRANSPARENT TESTA 4 (TT4) acts at the first step of flavonoid biosynthesis, and the loss of TT4 function causes a lack of flavonoid.	Flavonoids	122-131	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	21-24
30218862-1	2018	Flavonoids have been shown to possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.	Flavonoids	0-10	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	117-122
30342186-4	2018	Baicalein, as flavonoid extracted from the Scutellaria baicalensis, has been proved to possess the ability to activate Nrf2 signaling pathway in other cell types and mouse model.	Flavonoids	14-23	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
30268757-2	2018	This study aimed to assess the inhibitory effects of natural flavonoids against hCE1 and to find potential specific hCE1 inhibitors.	Flavonoids	61-71	carboxylesterase 1	Homo sapiens	80-84
30268757-3	2018	To this end, fifty-eight natural flavonoids were collected and their inhibitory effects against both hCE1 and hCE2 were assayed.	Flavonoids	33-43	carboxylesterase 1	Homo sapiens	101-105
30268757-3	2018	To this end, fifty-eight natural flavonoids were collected and their inhibitory effects against both hCE1 and hCE2 were assayed.	Flavonoids	33-43	carboxylesterase 2	Homo sapiens	110-114
30680297-1	2018	Statement of the Problem: Quercetin is a pharmacological flavonoid that can inhibit high mobility group box1 (HMGB1) protein, a non-histone nuclear protein that is implicated in inflammation.	Flavonoids	57-66	high mobility group box 1	Homo sapiens	84-108
30680297-1	2018	Statement of the Problem: Quercetin is a pharmacological flavonoid that can inhibit high mobility group box1 (HMGB1) protein, a non-histone nuclear protein that is implicated in inflammation.	Flavonoids	57-66	high mobility group box 1	Homo sapiens	110-115
30187077-0	2018	The Influence of 6-Prenylnaringenin and Selected Non-prenylated Flavonoids on the Activity of Kv1.3 Channels in Human Jurkat T Cells.	Flavonoids	64-74	potassium voltage-gated channel subfamily A member 3	Homo sapiens	94-99
30187077-11	2018	In accordance to our hypothesis the prenylated flavonoid (6-PR) was much more effective inhibitor of Kv1.3 channels than non-prenylated compounds selected for this study.	Flavonoids	47-56	potassium voltage-gated channel subfamily A member 3	Homo sapiens	101-106
30176084-0	2018	Two R2R3-MYB proteins are broad repressors of flavonoid and phenylpropanoid metabolism in poplar.	Flavonoids	46-55	MYB proto-oncogene, transcription factor	Homo sapiens	9-12
29981254-2	2018	TRANSPARENT TESTA 4 (TT4) acts at the first step of flavonoid biosynthesis, and the loss of TT4 function causes a lack of flavonoid.	Flavonoids	122-131	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	92-95
29981254-5	2018	We showed that TT4-mediated flavonoids negatively affect embryonic fatty acid biosynthesis.	Flavonoids	28-38	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	15-18
30176084-3	2018	In poplar, several R2R3 MYB transcription factors are known to be involved in flavonoid biosynthesis.	Flavonoids	78-87	MYB proto-oncogene, transcription factor	Homo sapiens	24-27
30505814-9	2018	The flavonoid either alone or in combination with paclitaxel therapy resulted in an increase in tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) protein expression and decrease in nuclear factor-kappaB p50 protein level in DU145 cells.	Flavonoids	4-13	phosphatase and tensin homolog	Homo sapiens	113-117
30505814-9	2018	The flavonoid either alone or in combination with paclitaxel therapy resulted in an increase in tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) protein expression and decrease in nuclear factor-kappaB p50 protein level in DU145 cells.	Flavonoids	4-13	nuclear factor kappa B subunit 1	Homo sapiens	233-236
30118763-0	2018	Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo.	Flavonoids	4-13	neurogenin 3	Rattus norvegicus	80-85
30477461-0	2018	Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines.	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	66-80
30149188-2	2018	In order to develop fluorescence polarization (FP) assay for flavonoids, a soluble recombinant protein human estrogen receptor alpha ligand binding domain (hERalpha-LBD) was produced in Escherichia coli strain.	Flavonoids	61-71	estrogen receptor 1	Homo sapiens	109-132
30477461-2	2018	Flavonoids have already been reported as modulators of the Wnt/beta-catenin pathway and hence they may serve as promising agents in the reversal of P-gp mediated cancer multi drug resistance (MDR).	Flavonoids	0-10	catenin beta 1	Homo sapiens	63-75
30477461-2	2018	Flavonoids have already been reported as modulators of the Wnt/beta-catenin pathway and hence they may serve as promising agents in the reversal of P-gp mediated cancer multi drug resistance (MDR).	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	148-152
30477461-3	2018	METHODS: In this study, we screened selected flavonoids against Wnt/beta-catenin signaling molecules.	Flavonoids	45-55	catenin beta 1	Homo sapiens	68-80
30477461-4	2018	The binding interaction of flavonoids (theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin) with GSK 3beta was determined by molecular docking.	Flavonoids	27-37	glycogen synthase kinase 3 beta	Homo sapiens	113-122
30477461-5	2018	Flavonoids on P-gp expression and the components of Wnt signaling in drug-resistant KBCHR8-5 cells were analyzed by western blotting and qRT-PCR.	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	14-18
30477461-6	2018	The MDR reversal potential of these selected flavonoids against P-gp mediated drug resistance was analyzed by cytotoxicity assay in KBCHR8-5 and MCF7/ADR cell lines.	Flavonoids	45-55	ATP binding cassette subfamily B member 1	Homo sapiens	64-68
30477461-9	2018	All the flavonoids selected in this study significantly decreased the expression of Wnt and GSK 3beta in KBCHR8-5 cells and subsequently modulates P-gp overexpression in this drug-resistant cell line.	Flavonoids	8-18	glycogen synthase kinase 3 beta	Homo sapiens	92-101
30477461-9	2018	All the flavonoids selected in this study significantly decreased the expression of Wnt and GSK 3beta in KBCHR8-5 cells and subsequently modulates P-gp overexpression in this drug-resistant cell line.	Flavonoids	8-18	ATP binding cassette subfamily B member 1	Homo sapiens	147-151
30477461-14	2018	CONCLUSION: The present findings illustrate that the studied flavonoids significantly enhances doxorubicin-mediated cell death through modulating P-gp expression pattern by targeting Wnt/beta-catenin signaling in drug-resistant KBCHR8-5 cells.	Flavonoids	61-71	ATP binding cassette subfamily B member 1	Homo sapiens	146-150
30477461-14	2018	CONCLUSION: The present findings illustrate that the studied flavonoids significantly enhances doxorubicin-mediated cell death through modulating P-gp expression pattern by targeting Wnt/beta-catenin signaling in drug-resistant KBCHR8-5 cells.	Flavonoids	61-71	catenin beta 1	Homo sapiens	187-199
30360615-0	2018	Structurally Different Flavonoid Subclasses Attenuate High-Fat and High-Fructose Diet Induced Metabolic Syndrome in Rats.	Flavonoids	23-32	FAT atypical cadherin 1	Rattus norvegicus	59-62
30478366-0	2018	Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways.	Flavonoids	6-16	matrix metallopeptidase 9	Homo sapiens	44-48
30478366-0	2018	Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways.	Flavonoids	6-16	AKT serine/threonine kinase 1	Homo sapiens	93-96
30469543-3	2018	This study aimed to evaluate the effects of the natural flavonoid taxifolin, luteolin, (-)-gallocatechin, and (-)-catechin on human P-gp activity.	Flavonoids	56-65	ATP binding cassette subfamily B member 1	Homo sapiens	132-136
30351934-0	2018	Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".	Flavonoids	19-28	ATP binding cassette subfamily B member 1	Homo sapiens	47-77
30450047-0	2018	Effect of Total Flavonoids of Rhizoma drynariae on Tibial Dyschondroplasia by Regulating BMP-2 and Runx2 Expression in Chickens.	Flavonoids	16-26	bone morphogenetic protein 2	Gallus gallus	89-94
30351934-0	2018	Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".	Flavonoids	19-28	ATP binding cassette subfamily C member 1	Homo sapiens	79-83
30351934-0	2018	Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".	Flavonoids	19-28	ATP binding cassette subfamily C member 1	Homo sapiens	85-90
30351934-1	2018	A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using "click chemistry".	Flavonoids	13-22	ATP binding cassette subfamily C member 1	Homo sapiens	40-81
30351934-1	2018	A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using "click chemistry".	Flavonoids	13-22	ATP binding cassette subfamily C member 1	Homo sapiens	83-87
30351934-1	2018	A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using "click chemistry".	Flavonoids	13-22	ATP binding cassette subfamily C member 1	Homo sapiens	89-94
30458720-0	2018	Two MYB transcription factors (CsMYB2 and CsMYB26) are involved in flavonoid biosynthesis in tea plant [Camellia sinensis (L.) O. Kuntze].	Flavonoids	67-76	MYB proto-oncogene, transcription factor	Homo sapiens	4-7
30458720-2	2018	MYB transcription factors (TFs) are considered potentially important regulators of flavonoid biosynthesis in plants.	Flavonoids	83-92	MYB proto-oncogene, transcription factor	Homo sapiens	0-3
30458720-3	2018	However, the molecular mechanisms by which MYB TFs regulate the flavonoid pathway in tea plant remain unknown.	Flavonoids	64-73	MYB proto-oncogene, transcription factor	Homo sapiens	43-46
30458720-4	2018	RESULTS: In this study, two R2R3-MYB TFs (CsMYB2 and CsMYB26) involved in flavonoid biosynthesis in tea plant were investigated.	Flavonoids	74-83	MYB proto-oncogene, transcription factor	Homo sapiens	33-36
29345961-3	2018	The aim of this study was to investigate the effects of two flavonoids, quercetin and kaempferol, and exogenous glutathione (GSH) on the expressions of phospho- and total-AKT levels in 3T3-L1 preadipocytes.	Flavonoids	60-70	thymoma viral proto-oncogene 1	Mus musculus	171-174
30445784-7	2018	The results from cell culture antidiabetic assays (insulin secretion, adipogenesis, and glucose uptake), protein expressions and molecular docking pointed that the methoxy group at position C-8 is responsible for antidiabetic property of selected flavonoids via glucose uptake mechanism indicated by up regulation of GLUT4 and C/EBP-alpha expressions.	Flavonoids	247-257	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	317-322
30445784-7	2018	The results from cell culture antidiabetic assays (insulin secretion, adipogenesis, and glucose uptake), protein expressions and molecular docking pointed that the methoxy group at position C-8 is responsible for antidiabetic property of selected flavonoids via glucose uptake mechanism indicated by up regulation of GLUT4 and C/EBP-alpha expressions.	Flavonoids	247-257	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	327-338
30466968-0	2018	Flavonoids isolated from Tibetan medicines, binding to GABAA receptor and the anticonvulsant activity.	Flavonoids	0-10	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	55-60
30466968-5	2018	PURPOSE: The purpose is to investigate structure-activity relationships of flavonoids isolated from ACN and AKM, for binding to the benzodiazepine site (BZ-S) of gamma-aminobutyric acid type A (GABAA) receptor complex, and to search for anticonvulsant compounds without undesirable effects such as myorelaxation and sedation.	Flavonoids	75-85	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	194-199
30466968-6	2018	STUDY DESIGN AND METHODS: The affinities of these flavonoids for the BZ-S of GABAA receptors were determined by [3H]flunitrazepam binding to mouse cerebellum membranes in vitro.	Flavonoids	50-60	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	77-82
30441755-6	2018	Lipid deposition, partial inflammatory-related factors (nuclear factor kappa B p65, cyclooxygenase-2, and interleukin-6 levels), and hepatic histopathological alterations were similarly attenuated by five kinds of flavonoids.	Flavonoids	214-224	prostaglandin-endoperoxide synthase 2	Mus musculus	84-100
30441755-6	2018	Lipid deposition, partial inflammatory-related factors (nuclear factor kappa B p65, cyclooxygenase-2, and interleukin-6 levels), and hepatic histopathological alterations were similarly attenuated by five kinds of flavonoids.	Flavonoids	214-224	interleukin 6	Mus musculus	106-119
30413758-5	2018	We found that endogenous levels of anthocyanins, members of the flavonoid group, were significantly lower in the aba3 mutant than in the wild type or the aba2 mutant under oxidative stress.	Flavonoids	64-73	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	154-158
30450047-0	2018	Effect of Total Flavonoids of Rhizoma drynariae on Tibial Dyschondroplasia by Regulating BMP-2 and Runx2 Expression in Chickens.	Flavonoids	16-26	runt related transcription factor 2	Gallus gallus	99-104
29161996-2	2018	In this present work, we search for the potential FAS inhibitors of TE domain from the ZINC database based on similarity search using three natural compounds as templates, including flavonoids, terpenoids, and phenylpropanoids.	Flavonoids	182-192	fatty acid synthase	Homo sapiens	50-53
30146950-4	2018	The total polyphenol and flavonoid content of LSM apple juice was approximately 2 times higher than that of blender apple juice because polyphenols and flavonoids can be used as substrates by PPO.	Flavonoids	25-34	polyphenol oxidase, chloroplastic	Malus domestica	192-195
30146950-4	2018	The total polyphenol and flavonoid content of LSM apple juice was approximately 2 times higher than that of blender apple juice because polyphenols and flavonoids can be used as substrates by PPO.	Flavonoids	152-162	polyphenol oxidase, chloroplastic	Malus domestica	192-195
30003913-9	2018	The present work suggests that few of the selected flavonoids have strong potential to be used as alternative insulin secretagogues in diabetic treatment.	Flavonoids	51-61	insulin	Homo sapiens	110-117
29216799-0	2018	Flavonoids as potent allosteric inhibitors of protein tyrosine phosphatase 1B: molecular dynamics simulation and free energy calculation.	Flavonoids	0-10	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	46-77
29068268-3	2018	The focus of this study is to investigate the possibilities of MMP-9 inhibition by flavonol class of bioflavonoids by studying their crucial binding interactions at the active site of MMP 9 using molecular docking (Glide XP and QPLD) and further improvisation by post-docking MM-GBSA and molecular dynamic (MD) simulations.	Flavonoids	101-114	matrix metallopeptidase 9	Homo sapiens	63-68
29068268-3	2018	The focus of this study is to investigate the possibilities of MMP-9 inhibition by flavonol class of bioflavonoids by studying their crucial binding interactions at the active site of MMP 9 using molecular docking (Glide XP and QPLD) and further improvisation by post-docking MM-GBSA and molecular dynamic (MD) simulations.	Flavonoids	101-114	matrix metallopeptidase 9	Homo sapiens	184-189
29216799-4	2018	Herein, the molecular interactions between the allosteric site of PTP1B with three non-competitive flavonoids, (MOR), (MOK), and (DPO) have been investigated.	Flavonoids	99-109	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	66-71
30333884-4	2018	Kaempferol, a bioflavonoid, reportedly inhibits estrogen receptor-alpha (ERalpha) in hormone receptor-positive breast cancer cells.	Flavonoids	14-26	estrogen receptor 1	Homo sapiens	48-71
30035335-8	2018	Human phospho-kinase array and pull-down assay results showed that quercetin-3-methyl ether (Q3ME) is a natural flavonoid compound that interacted with AKT and ERKs and inhibited their kinase activities.	Flavonoids	112-121	AKT serine/threonine kinase 1	Homo sapiens	152-155
30333884-4	2018	Kaempferol, a bioflavonoid, reportedly inhibits estrogen receptor-alpha (ERalpha) in hormone receptor-positive breast cancer cells.	Flavonoids	14-26	estrogen receptor 1	Homo sapiens	73-80
30364385-2	2018	The number and location of phenolic hydroxyl of the flavonoids will significantly influence the inhibition of tyrosinase activity.	Flavonoids	52-62	tyrosinase	Rattus norvegicus	110-120
30373602-5	2018	The effects of flavonoid treatment on melanoma sensitivity towards T cells were investigated using Jurkat cell killing, cytotoxicity, cell viability, and IL-2 secretion assays.	Flavonoids	15-24	interleukin 2	Homo sapiens	154-158
30373602-7	2018	Human peripheral blood mononuclear cells were used to examine the influence of flavonoids on PD-L1 expression in dendritic cells and cytotoxicity of cocultured cytokine-induced killer cells by cell killing assays.	Flavonoids	79-89	CD274 molecule	Homo sapiens	93-98
30373602-9	2018	The IFN-gamma-induced PD-L1 upregulation was significantly inhibited by flavonoids, especially apigenin, with correlated reductions in STAT1 phosphorylation.	Flavonoids	72-82	CD274 molecule	Homo sapiens	22-27
30367624-0	2018	Taxifolin, a natural flavonoid interacts with cell cycle regulators causes cell cycle arrest and causes tumor regression by activating Wnt/ beta -catenin signaling pathway.	Flavonoids	21-30	catenin beta 1	Homo sapiens	140-153
29894785-1	2018	In this work, the hydroxyl-related differences of binding properties and inhibitory activities of dietary flavonoids, namely chrysin, baicalein and apigenin against purine nucleoside phosphorylase (PNP) were investigated.	Flavonoids	106-116	purine nucleoside phosphorylase	Homo sapiens	198-201
29894785-5	2018	Results from molecular modeling revealed that there are two binding sites, i.e. active site (major) and tryptophan site (minor) on PNP, and the binding of these flavonoids might induce a serious conformational destabilization of PNP as a result of altering the micro-environment and morphology by flavonoids.	Flavonoids	161-171	purine nucleoside phosphorylase	Homo sapiens	131-134
29894785-0	2018	Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase.	Flavonoids	47-57	purine nucleoside phosphorylase	Homo sapiens	81-112
29894785-5	2018	Results from molecular modeling revealed that there are two binding sites, i.e. active site (major) and tryptophan site (minor) on PNP, and the binding of these flavonoids might induce a serious conformational destabilization of PNP as a result of altering the micro-environment and morphology by flavonoids.	Flavonoids	161-171	purine nucleoside phosphorylase	Homo sapiens	229-232
29894785-5	2018	Results from molecular modeling revealed that there are two binding sites, i.e. active site (major) and tryptophan site (minor) on PNP, and the binding of these flavonoids might induce a serious conformational destabilization of PNP as a result of altering the micro-environment and morphology by flavonoids.	Flavonoids	297-307	purine nucleoside phosphorylase	Homo sapiens	131-134
29894785-5	2018	Results from molecular modeling revealed that there are two binding sites, i.e. active site (major) and tryptophan site (minor) on PNP, and the binding of these flavonoids might induce a serious conformational destabilization of PNP as a result of altering the micro-environment and morphology by flavonoids.	Flavonoids	297-307	purine nucleoside phosphorylase	Homo sapiens	229-232
30304866-9	2018	The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism.	Flavonoids	203-212	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	233-237
30148999-3	2018	We examined the efficiency of seven flavonoids in preventing an increase in ACE activity in aorta of rats exposed to ionizing radiation.	Flavonoids	36-46	angiotensin I converting enzyme	Rattus norvegicus	76-79
30301254-0	2018	The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme.	Flavonoids	25-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	74-80
30301254-4	2018	The aim of this study was to focus on possible interactions between the 30 most commonly encountered flavonoid aglycones on the metabolic activity of CYP3A4 enzyme.	Flavonoids	101-110	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	150-156
30301254-8	2018	Out of the 30 flavonoids tested, 7 significantly inhibited CYP3A4, most prominent being acacetin that inhibited 95% of enzyme activity at 1 microM concentration.	Flavonoids	14-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65
30301254-10	2018	These results alert on possible flavonoid-drug interactions on the level of CYP3A4.	Flavonoids	32-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	76-82
30301267-5	2018	The mechanisms of characteristic flavonoids in CAL were evaluated involving inflammation and intestine contraction aspects.	Flavonoids	33-43	filamin binding LIM protein 1	Rattus norvegicus	47-50
30301267-10	2018	This study demonstrated that CAL, and its flavonoids" regulatory effects on IBD through anti-inflammation and inhibition of intestine muscle contraction, can provide basic information on developing new drugs or supplements against IBD based on CAL.	Flavonoids	42-52	filamin binding LIM protein 1	Rattus norvegicus	244-247
30197003-0	2018	Crystal structure of GSK3beta in complex with the flavonoid, morin.	Flavonoids	50-59	glycogen synthase kinase 3 beta	Homo sapiens	21-29
30197003-3	2018	Morin, a flavonoid that is abundant in nature, was found as an inhibitor of GSK3beta that can reduce tau pathology in vivo and in vitro.	Flavonoids	9-18	glycogen synthase kinase 3 beta	Homo sapiens	76-84
29990830-0	2018	Flavonoid-rich Scabiosa comosa inflorescence extract attenuates CCl4-induced hepatic fibrosis by modulating TGF-beta-induced Smad3 phosphorylation.	Flavonoids	0-9	C-C motif chemokine ligand 4	Rattus norvegicus	64-68
30232261-9	2018	Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P &lt; 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta.	Flavonoids	45-54	interleukin 1 beta	Homo sapiens	140-148
30232261-9	2018	Preincubation of LAD2 cells with the natural flavonoid methoxyluteolin (1-100 mM) inhibits (P &lt; 0.0001) secretion and gene expression of IL-1beta, procaspase-1, and pro-IL-1beta.	Flavonoids	45-54	interleukin 1 beta	Homo sapiens	168-180
29990830-2	2018	In the study, we investigated the anti-fibrotic efficacy of flavonoid-rich Scabiosa comosa inflorescence extract (TF-SC) in a rat model of CCl4-induced hepatic fibrosis and explored its underlying mechanism in vitro and in vivo.	Flavonoids	60-69	C-C motif chemokine ligand 4	Rattus norvegicus	139-143
30223923-0	2018	Immunomodulatory and anti-inflammatory effects of total flavonoids of Astragalus by regulating NF-KappaB and MAPK signalling pathways in RAW 264.7 macrophages.	Flavonoids	56-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
30227999-0	2018	Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.	Flavonoids	21-31	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
30227999-3	2018	In this study, a natural flavonoid library was established and tested for their potential Nrf2 inducing effects.	Flavonoids	25-34	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30227999-4	2018	Based on QR inducing effect of flavonoids, their structure-activity relationship (SAR) on Nrf2 induction was summarized, and twenty flavonoids were firstly identified to be potential activators of Nrf2-mediated defensive response.	Flavonoids	31-41	NFE2 like bZIP transcription factor 2	Homo sapiens	197-201
30227999-4	2018	Based on QR inducing effect of flavonoids, their structure-activity relationship (SAR) on Nrf2 induction was summarized, and twenty flavonoids were firstly identified to be potential activators of Nrf2-mediated defensive response.	Flavonoids	132-142	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30227999-4	2018	Based on QR inducing effect of flavonoids, their structure-activity relationship (SAR) on Nrf2 induction was summarized, and twenty flavonoids were firstly identified to be potential activators of Nrf2-mediated defensive response.	Flavonoids	132-142	NFE2 like bZIP transcription factor 2	Homo sapiens	197-201
29981370-5	2018	Mounting evidence revealed that numerous bioflavonoids, obtained from a variety of dietary fruits or plants as well as medicinal herbal sources, exhibit protective or therapeutic functions versus development of neurodegenerative diseases mainly through modulation of different compartments of ERK signaling pathway.	Flavonoids	41-54	mitogen-activated protein kinase 1	Homo sapiens	293-296
29981370-8	2018	Here, we summarized the effect of natural bioflavonoids on ERK signaling pathway and their molecular mechanism.	Flavonoids	42-55	mitogen-activated protein kinase 1	Homo sapiens	59-62
29851162-3	2018	For example, flavonoids including morin and myricetin significantly inhibited purified, recombinant sheep serotonin N-acetyltransferase (SNAT).	Flavonoids	13-23	serotonin N-acetyltransferase	Ovis aries	106-135
29851162-3	2018	For example, flavonoids including morin and myricetin significantly inhibited purified, recombinant sheep serotonin N-acetyltransferase (SNAT).	Flavonoids	13-23	serotonin N-acetyltransferase	Ovis aries	137-141
29660753-2	2018	Factors that have been shown to increase expression of miR-155 may be mitigated by WS 1442, an extract of hawthorn leaves and flowers (Crataegus special extract) that contains a range of pharmacologically active substances including oligomeric proanthocyanidins and flavonoids.	Flavonoids	266-276	microRNA 155	Homo sapiens	55-62
29779214-2	2018	Cyanidin-3-glucoside (C3G) is a major component in the flavonoid family and has shown anti-inflammatory, anti-oxidant and anti-tumour activity.	Flavonoids	55-64	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	0-25
29508282-0	2018	Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.	Flavonoids	73-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
29783019-0	2018	Total flavonoid extract of Epimedium herb increases the peak bone mass of young rats involving enhanced activation of the AC10/cAMP/PKA/CREB pathway.	Flavonoids	6-15	cathelicidin antimicrobial peptide	Rattus norvegicus	127-131
30182194-6	2018	Compared with the control calli, the MdERF1B-overexpressing calli showed increased expression levels of MdACO1, MdERF1, and MdERF3 in the ethylene pathway and MdCHS, MdCHI, MdF3H, MdDFR, MdANS, MdLAR, MdANR, MdMYB9 and MdMYB11 in the flavonoid pathway.	Flavonoids	234-243	ethylene-responsive transcription factor RAP2-3-like	Malus domestica	37-43
28990837-2	2018	Quercetin is a dietary flavonoid has extremely low water solubility and found to possess CYP3A inhibitory activity.	Flavonoids	23-32	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	89-94
30356365-0	2018	Studies on the Interaction between Three Small Flavonoid Molecules and Bovine Lactoferrin.	Flavonoids	47-56	lactotransferrin	Bos taurus	78-89
30248132-7	2018	Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1beta secretion, through inhibition of the ATP/P2X7R signaling.	Flavonoids	14-23	interleukin 1 beta	Mus musculus	94-111
30248132-7	2018	Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1beta secretion, through inhibition of the ATP/P2X7R signaling.	Flavonoids	14-23	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	153-158
29783019-0	2018	Total flavonoid extract of Epimedium herb increases the peak bone mass of young rats involving enhanced activation of the AC10/cAMP/PKA/CREB pathway.	Flavonoids	6-15	cAMP responsive element binding protein 1	Rattus norvegicus	136-140
30008441-0	2018	Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr-/- mice.	Flavonoids	25-35	low density lipoprotein receptor	Mus musculus	114-118
29960001-0	2018	Flavonoids interfere with NLRP3 inflammasome activation.	Flavonoids	0-10	NLR family pyrin domain containing 3	Homo sapiens	26-31
29960001-10	2018	The present study, for the first time, demonstrated the structure-activity profiles of flavonoids in NLRP3 inflammasome activation and mechanisms of cellular action.	Flavonoids	87-97	NLR family pyrin domain containing 3	Homo sapiens	101-106
29960001-11	2018	Certain flavonoids including apigenin are expected to ameliorate the inflammatory symptoms in autoinflammatory diseases associated with NLRP3 inflammasome activation.	Flavonoids	8-18	NLR family pyrin domain containing 3	Homo sapiens	136-141
29698678-5	2018	All of the tested individual citrus flavonoids demonstrated DPP-4 inhibitory activity, with IC50 values ranging from 485 muM (rutin) to 5700 muM (hesperitin and eriodictyol).	Flavonoids	36-46	dipeptidyl peptidase 4	Homo sapiens	60-65
29698678-9	2018	While our data demonstrated that citrus bioflavonoid based supplements do possess DPP-4 inhibitory activity, they are several orders of magnitude less potent than gliptins.	Flavonoids	40-52	dipeptidyl peptidase 4	Homo sapiens	82-87
30365230-0	2018	Flavonoids as putative modulators of Delta4-, Delta5-, and Delta6-desaturases: Studies in cultured hepatocytes, myocytes, and adipocytes.	Flavonoids	0-10	delta like canonical Notch ligand 4	Mus musculus	65-77
30031314-0	2018	The flavonoid kurarinone inhibits clinical progression of EAE through inhibiting Th1 and Th17 cell differentiation and proliferation.	Flavonoids	4-13	negative elongation factor complex member C/D, Th1l	Mus musculus	81-84
30036771-0	2018	Isomeric flavonoid aglycones derived from Epimedii Folium exerted different intensities in anti-osteoporosis through OPG/RANKL protein targets.	Flavonoids	9-18	TNF receptor superfamily member 11B	Rattus norvegicus	117-120
30036771-0	2018	Isomeric flavonoid aglycones derived from Epimedii Folium exerted different intensities in anti-osteoporosis through OPG/RANKL protein targets.	Flavonoids	9-18	TNF superfamily member 11	Rattus norvegicus	121-126
30036771-1	2018	Two Epimedium-derived isomeric flavonoids, CIT and IT, had the therapeutic effect in osteopenic rats.	Flavonoids	31-41	citron rho-interacting serine/threonine kinase	Rattus norvegicus	43-46
30036771-9	2018	In conclusion, the combination of isomeric flavonoids (CIT/IT) and OPG/RANKL targets attenuated the excitation effects of OPG or RANKL on RANKL.	Flavonoids	43-53	citron rho-interacting serine/threonine kinase	Rattus norvegicus	55-58
29753067-0	2018	Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.	Flavonoids	26-36	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	44-50
29753067-4	2018	Some flavonoids such as licoflavone (12) and irilone (30) exhibited the selective inhibition toward CYP3 A4 rather than other major human CYPs.	Flavonoids	5-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	100-107
29753067-8	2018	Finally, a quantitative structure-activity relationship (QSAR) of flavonoids with their inhibitory effects toward CYP3 A4 was established using computational methods.	Flavonoids	66-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	114-121
29753067-9	2018	Our findings illustrated the high risk of herb-drug interactions (HDIs) caused by flavonoids and revealed the vital structures requirement of natural flavonoids for the HDIs with clinical drugs eliminated by CYP3 A4.	Flavonoids	150-160	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	208-215
30214075-3	2018	Here, we present a rational follow-up investigation of the interaction between ELAV isoform HuR and structurally-related compounds (i.e., flavonoids and coumarins), naturally decorated with different functional groups, by means of STD-NMR and Molecular Modelling.	Flavonoids	138-148	ELAV like RNA binding protein 1	Homo sapiens	92-95
30189396-1	2018	Several flavonoids and their biosynthetic precursor chalcones were designed and synthesized to improve the biological effects of the lead compound 2"-hydroxyflavonone against androgen receptor (AR)-dependent transcriptional stimulation.	Flavonoids	8-18	androgen receptor	Homo sapiens	175-192
30189396-1	2018	Several flavonoids and their biosynthetic precursor chalcones were designed and synthesized to improve the biological effects of the lead compound 2"-hydroxyflavonone against androgen receptor (AR)-dependent transcriptional stimulation.	Flavonoids	8-18	androgen receptor	Homo sapiens	194-196
29778797-1	2018	Beside other pharmaceutical benefits, flavonoids are known for their potent alpha-glucosidase inhibition.	Flavonoids	38-48	sucrase-isomaltase	Homo sapiens	76-93
30036771-9	2018	In conclusion, the combination of isomeric flavonoids (CIT/IT) and OPG/RANKL targets attenuated the excitation effects of OPG or RANKL on RANKL.	Flavonoids	43-53	TNF receptor superfamily member 11B	Rattus norvegicus	122-125
30036771-9	2018	In conclusion, the combination of isomeric flavonoids (CIT/IT) and OPG/RANKL targets attenuated the excitation effects of OPG or RANKL on RANKL.	Flavonoids	43-53	TNF superfamily member 11	Rattus norvegicus	129-134
30036771-9	2018	In conclusion, the combination of isomeric flavonoids (CIT/IT) and OPG/RANKL targets attenuated the excitation effects of OPG or RANKL on RANKL.	Flavonoids	43-53	TNF superfamily member 11	Rattus norvegicus	129-134
30008441-3	2018	Previous prevention studies demonstrated that the citrus flavonoids, naringenin and nobiletin, protect against obesity and metabolic dysfunction in Ldlr-/- mice fed a high-fat cholesterol-containing (HFHC) diet.	Flavonoids	57-67	low density lipoprotein receptor	Mus musculus	148-152
30008441-5	2018	In this report, we show that, in Ldlr-/- mice with diet-induced obesity, citrus flavonoid supplementation to a HFHC diet reversed existing obesity and adipocyte size and number through enhanced energy expenditure and increased hepatic fatty acid oxidation.	Flavonoids	80-89	low density lipoprotein receptor	Mus musculus	33-37
29726034-0	2018	Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF-alpha and IL-6) and the expression of COX-2.	Flavonoids	0-10	tumor necrosis factor	Homo sapiens	71-80
30463833-2	2018	As a complex containing several kinds of flavonoids, FLCWK has the potential to impact the drug metabolism enzyme P450 3A4 (CYP3A4) and nuclear receptors.	Flavonoids	41-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130
29726034-0	2018	Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF-alpha and IL-6) and the expression of COX-2.	Flavonoids	0-10	interleukin 6	Homo sapiens	85-89
29726034-0	2018	Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF-alpha and IL-6) and the expression of COX-2.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	113-118
30301316-0	2018	Regulation of AKT Activity by Inhibition of the Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interaction Using Flavonoids.	Flavonoids	109-119	AKT serine/threonine kinase 1	Homo sapiens	14-17
30301316-3	2018	Liposome pulldown assays coupled with fluorescence spectrometry were used to screen flavonoids for inhibition of the AKT PH-PIP3 interaction.	Flavonoids	84-94	AKT serine/threonine kinase 1	Homo sapiens	117-120
30301316-5	2018	Several flavonoids showing up to 50% inhibition of the AKT PH-PIP3 interaction decreased the level of AKT activation at the cellular level.	Flavonoids	8-18	AKT serine/threonine kinase 1	Homo sapiens	55-58
30301316-5	2018	Several flavonoids showing up to 50% inhibition of the AKT PH-PIP3 interaction decreased the level of AKT activation at the cellular level.	Flavonoids	8-18	AKT serine/threonine kinase 1	Homo sapiens	102-105
29812952-6	2018	The potential and versatility of the SP-C11-resorc[4]arene stationary phase were shown as well in the separation of highly polar natural products (namely, flavonoids), under reversed-phase (RP) conditions, and of fullerenes C60 and C70, by using apolar solvents as mobile phases.	Flavonoids	155-165	RNA polymerase III subunit K	Homo sapiens	40-43
30115883-3	2018	Three of the prenylated flavonoids, namely GF-1, GF-4 and GF-9, significantly induced the differentiation of B16-F10 cells; the inductions included increase of tyrosinase activity, tyrosinase protein, and melanin content.	Flavonoids	24-34	gonadal fat pad weight 1	Mus musculus	43-62
30115883-3	2018	Three of the prenylated flavonoids, namely GF-1, GF-4 and GF-9, significantly induced the differentiation of B16-F10 cells; the inductions included increase of tyrosinase activity, tyrosinase protein, and melanin content.	Flavonoids	24-34	tyrosinase	Mus musculus	181-191
30025348-1	2018	In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs).	Flavonoids	66-75	sigma non-opioid intracellular receptor 1	Homo sapiens	132-148
30025348-1	2018	In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs).	Flavonoids	66-75	sigma non-opioid intracellular receptor 1	Homo sapiens	150-157
30025348-1	2018	In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs).	Flavonoids	66-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	226-246
30025348-1	2018	In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs).	Flavonoids	66-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	248-252
30025348-1	2018	In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs).	Flavonoids	66-75	arachidonate 5-lipoxygenase	Homo sapiens	255-269
30025348-1	2018	In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs).	Flavonoids	66-75	arachidonate 5-lipoxygenase	Homo sapiens	271-276
29879658-0	2018	A flavonoids compound inhibits osteoclast differentiation by attenuating RANKL induced NFATc-1/c-Fos induction.	Flavonoids	2-12	TNF superfamily member 11	Homo sapiens	73-78
29944876-2	2018	Some studies reported that hesperidin (HDN), a citrus bioflavonoid, can bind to and stimulate peroxisome proliferator-activator receptor-gamma (PPAR-gamma) which may mediate its antidiabetic, anti-inflammatory and anti-oxidant effects.	Flavonoids	54-66	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	94-142
29944876-2	2018	Some studies reported that hesperidin (HDN), a citrus bioflavonoid, can bind to and stimulate peroxisome proliferator-activator receptor-gamma (PPAR-gamma) which may mediate its antidiabetic, anti-inflammatory and anti-oxidant effects.	Flavonoids	54-66	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	144-154
30061214-1	2018	BACKGROUND/AIM: The expression of cannabinoid receptor-1 (CB1-R) seems to be modulated by bioactive natural components such as the flavonoid quercetin.	Flavonoids	131-140	cannabinoid receptor 1 (brain)	Mus musculus	34-56
30061214-1	2018	BACKGROUND/AIM: The expression of cannabinoid receptor-1 (CB1-R) seems to be modulated by bioactive natural components such as the flavonoid quercetin.	Flavonoids	131-140	cannabinoid receptor 1 (brain)	Mus musculus	58-61
29758313-2	2018	The flavonoids effect on gentamicin (GEN)-induced oxidative stress (OS) in systemic circulation was evaluated in terms of reactive oxygen species (ROS) production, enzymatic antioxidant defenses superoxide dismutase (SOD) and catalase (CAT), and lipid peroxidation (LP) in vitro on human leukocytes and in vivo on rat whole blood.	Flavonoids	4-14	catalase	Homo sapiens	226-234
29758313-2	2018	The flavonoids effect on gentamicin (GEN)-induced oxidative stress (OS) in systemic circulation was evaluated in terms of reactive oxygen species (ROS) production, enzymatic antioxidant defenses superoxide dismutase (SOD) and catalase (CAT), and lipid peroxidation (LP) in vitro on human leukocytes and in vivo on rat whole blood.	Flavonoids	4-14	catalase	Homo sapiens	236-239
29736565-0	2018	The Flavonoid Apigenin Is a Progesterone Receptor Modulator with In Vivo Activity in the Uterus.	Flavonoids	4-13	progesterone receptor	Homo sapiens	28-49
29879658-0	2018	A flavonoids compound inhibits osteoclast differentiation by attenuating RANKL induced NFATc-1/c-Fos induction.	Flavonoids	2-12	nuclear factor of activated T cells 1	Homo sapiens	87-94
29879658-0	2018	A flavonoids compound inhibits osteoclast differentiation by attenuating RANKL induced NFATc-1/c-Fos induction.	Flavonoids	2-12	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
30050147-0	2018	Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kgamma mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells.	Flavonoids	0-10	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	99-108
29981500-0	2018	A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models.	Flavonoids	8-17	androgen receptor	Mus musculus	38-55
29920325-6	2018	We further examined the potential role of the flavonoid biosynthetic pathway using a dihydroflavonol 4-reductase (DFR) mutant (tt3) and quantitative RT-PCR (qRT-PCR) analysis, and found that the tt3 mutant was deprived of transcriptional up-regulation of three genes related to anthocyanin biosynthesis, modification and transport under Pi deficiency.	Flavonoids	46-55	dihydroflavonol 4-reductase	Arabidopsis thaliana	85-112
29920325-6	2018	We further examined the potential role of the flavonoid biosynthetic pathway using a dihydroflavonol 4-reductase (DFR) mutant (tt3) and quantitative RT-PCR (qRT-PCR) analysis, and found that the tt3 mutant was deprived of transcriptional up-regulation of three genes related to anthocyanin biosynthesis, modification and transport under Pi deficiency.	Flavonoids	46-55	dihydroflavonol 4-reductase	Arabidopsis thaliana	114-117
30050147-0	2018	Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kgamma mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells.	Flavonoids	0-10	AKT serine/threonine kinase 1	Homo sapiens	123-126
30050147-0	2018	Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kgamma mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells.	Flavonoids	0-10	mechanistic target of rapamycin kinase	Homo sapiens	127-131
30050147-0	2018	Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kgamma mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells.	Flavonoids	0-10	ribosomal protein S6 kinase B1	Homo sapiens	132-138
30050147-6	2018	Molecular docking revealed that these flavonoids dock in the ATP binding pocket of PI3Kgamma.	Flavonoids	38-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	83-92
30050147-7	2018	Importantly, treatment with these flavonoids decreased the levels of PI3Kgamma-p110, phospho-PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6K, and phospho-ULK.	Flavonoids	34-44	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	69-78
30050147-7	2018	Importantly, treatment with these flavonoids decreased the levels of PI3Kgamma-p110, phospho-PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6K, and phospho-ULK.	Flavonoids	34-44	endogenous retrovirus group K member 15	Homo sapiens	79-83
30050147-7	2018	Importantly, treatment with these flavonoids decreased the levels of PI3Kgamma-p110, phospho-PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6K, and phospho-ULK.	Flavonoids	34-44	AKT serine/threonine kinase 1	Homo sapiens	107-110
30050147-7	2018	Importantly, treatment with these flavonoids decreased the levels of PI3Kgamma-p110, phospho-PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6K, and phospho-ULK.	Flavonoids	34-44	mechanistic target of rapamycin kinase	Homo sapiens	120-124
30050147-7	2018	Importantly, treatment with these flavonoids decreased the levels of PI3Kgamma-p110, phospho-PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6K, and phospho-ULK.	Flavonoids	34-44	ribosomal protein S6 kinase B1	Homo sapiens	134-140
30050147-8	2018	Pretreatment with PI3Kgamma specific inhibitor AS605240 potentiated flavonoids-mediated inactivation of AKT, mTOR, p70S6K, ULK, and apoptosis.	Flavonoids	68-78	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	18-27
30050147-8	2018	Pretreatment with PI3Kgamma specific inhibitor AS605240 potentiated flavonoids-mediated inactivation of AKT, mTOR, p70S6K, ULK, and apoptosis.	Flavonoids	68-78	AKT serine/threonine kinase 1	Homo sapiens	104-107
30050147-8	2018	Pretreatment with PI3Kgamma specific inhibitor AS605240 potentiated flavonoids-mediated inactivation of AKT, mTOR, p70S6K, ULK, and apoptosis.	Flavonoids	68-78	mechanistic target of rapamycin kinase	Homo sapiens	109-113
30050147-8	2018	Pretreatment with PI3Kgamma specific inhibitor AS605240 potentiated flavonoids-mediated inactivation of AKT, mTOR, p70S6K, ULK, and apoptosis.	Flavonoids	68-78	ribosomal protein S6 kinase B1	Homo sapiens	115-121
30050147-9	2018	Taken together, these findings represent a novel mechanism by which downregulation of PI3Kgamma-p110 and consequent interruption of PI3K/AKT/mTOR/p70S6K/ULK signaling pathway might play a critical functional role in these flavonoids-induced cell cycle arrest at G2/M phase, apoptosis, and autophagy.	Flavonoids	222-232	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	86-95
30050147-9	2018	Taken together, these findings represent a novel mechanism by which downregulation of PI3Kgamma-p110 and consequent interruption of PI3K/AKT/mTOR/p70S6K/ULK signaling pathway might play a critical functional role in these flavonoids-induced cell cycle arrest at G2/M phase, apoptosis, and autophagy.	Flavonoids	222-232	endogenous retrovirus group K member 15	Homo sapiens	96-100
30050147-9	2018	Taken together, these findings represent a novel mechanism by which downregulation of PI3Kgamma-p110 and consequent interruption of PI3K/AKT/mTOR/p70S6K/ULK signaling pathway might play a critical functional role in these flavonoids-induced cell cycle arrest at G2/M phase, apoptosis, and autophagy.	Flavonoids	222-232	AKT serine/threonine kinase 1	Homo sapiens	137-140
30050147-9	2018	Taken together, these findings represent a novel mechanism by which downregulation of PI3Kgamma-p110 and consequent interruption of PI3K/AKT/mTOR/p70S6K/ULK signaling pathway might play a critical functional role in these flavonoids-induced cell cycle arrest at G2/M phase, apoptosis, and autophagy.	Flavonoids	222-232	mechanistic target of rapamycin kinase	Homo sapiens	141-145
30050147-9	2018	Taken together, these findings represent a novel mechanism by which downregulation of PI3Kgamma-p110 and consequent interruption of PI3K/AKT/mTOR/p70S6K/ULK signaling pathway might play a critical functional role in these flavonoids-induced cell cycle arrest at G2/M phase, apoptosis, and autophagy.	Flavonoids	222-232	ribosomal protein S6 kinase B1	Homo sapiens	146-152
30002398-0	2018	Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H22 liver tumor-bearing mice.	Flavonoids	51-61	histocompatibility 22	Mus musculus	95-98
30317778-1	2018	Objective: The effect of total flavonoids of litchi (TFL) on nuclear translocation of nuclear factor-kappa B (NF- kappa B) in rat hepatic stellate cell line (HSC-T6) induced by transforming growth factor - beta 1 (TGF- beta 1) in vitro was studied to explore the mechanism of action of anti-hepatic fibrosis drugs.	Flavonoids	31-41	transforming growth factor, beta 1	Rattus norvegicus	177-212
29723508-1	2018	Flavonoids and their metabolites are well reported to modulate the activation/phosphorylation of various cellular kinases, such as ERK1/2 and JNK, although the mechanism by which they do so is unclear.	Flavonoids	0-10	mitogen-activated protein kinase 3	Homo sapiens	131-137
29723508-1	2018	Flavonoids and their metabolites are well reported to modulate the activation/phosphorylation of various cellular kinases, such as ERK1/2 and JNK, although the mechanism by which they do so is unclear.	Flavonoids	0-10	mitogen-activated protein kinase 8	Homo sapiens	142-145
30105071-4	2018	However, the effect of SIRT1 on the regulation of human umbilical vein endothelial cell (HUVEC) senescence with total flavonoids (TFs) has not been addressed previously.	Flavonoids	118-128	sirtuin 1	Homo sapiens	23-28
30041464-0	2018	Flavonoids as Putative Epi-Modulators: Insight into Their Binding Mode with BRD4 Bromodomains Using Molecular Docking and Dynamics.	Flavonoids	0-10	bromodomain containing 4	Homo sapiens	76-80
30041464-2	2018	Recently, different studies showed that flavonoids have the potential to inhibit bromodomain and extraterminal (BET) bromodomains.	Flavonoids	40-50	delta/notch like EGF repeat containing	Homo sapiens	112-115
30041464-12	2018	This work may serve as the basis for scaffold optimization and the further characterization of flavonoids as BET inhibitors.	Flavonoids	95-105	delta/notch like EGF repeat containing	Homo sapiens	109-112
30002398-2	2018	The present study aims to explore the antitumor and immunomodulatory effects of total flavonoids extract from persimmon leaves (PLF) in H22 liver tumor-bearing mice.	Flavonoids	86-96	histocompatibility 22	Mus musculus	136-139
28745105-0	2018	Honey flavonoids inhibit hOATP2B1 and hOATP1A2 transporters and hOATP-mediated rosuvastatin cell uptake in vitro.	Flavonoids	6-16	solute carrier organic anion transporter family member 2B1	Homo sapiens	25-33
29990327-0	2018	Flavonoid compound icariin enhances BMP-2 induced differentiation and signalling by targeting to connective tissue growth factor (CTGF) in SAMP6 osteoblasts.	Flavonoids	0-9	bone morphogenetic protein 2	Mus musculus	36-41
29990327-0	2018	Flavonoid compound icariin enhances BMP-2 induced differentiation and signalling by targeting to connective tissue growth factor (CTGF) in SAMP6 osteoblasts.	Flavonoids	0-9	cellular communication network factor 2	Mus musculus	97-128
29990327-0	2018	Flavonoid compound icariin enhances BMP-2 induced differentiation and signalling by targeting to connective tissue growth factor (CTGF) in SAMP6 osteoblasts.	Flavonoids	0-9	cellular communication network factor 2	Mus musculus	130-134
29976410-0	2018	Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction.	Flavonoids	0-10	ribosomal protein S19	Homo sapiens	42-47
29976410-0	2018	Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction.	Flavonoids	0-10	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
28745105-10	2018	The inhibition of the hOATP1A2-mediated transport of rosuvastatin by these flavonoids was weaker.	Flavonoids	75-85	solute carrier organic anion transporter family member 1A2	Homo sapiens	22-30
29684859-0	2018	Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.	Flavonoids	33-42	mitogen-activated protein kinase 14	Mus musculus	80-83
29684859-0	2018	Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.	Flavonoids	33-42	peroxisome proliferator activated receptor alpha	Mus musculus	84-94
29584932-0	2018	Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids.	Flavonoids	83-93	aryl hydrocarbon receptor	Homo sapiens	34-59
29584932-1	2018	Dietary flavonoids are used in treatment of multiple diseases, and their antiinflammatory effects in the intestine are due, in part, to interactions with gut microflora and possibly due to modulation of aryl hydrocarbon receptor (AhR) signaling.	Flavonoids	8-18	aryl hydrocarbon receptor	Homo sapiens	203-228
29584932-1	2018	Dietary flavonoids are used in treatment of multiple diseases, and their antiinflammatory effects in the intestine are due, in part, to interactions with gut microflora and possibly due to modulation of aryl hydrocarbon receptor (AhR) signaling.	Flavonoids	8-18	aryl hydrocarbon receptor	Homo sapiens	230-233
29584932-2	2018	In this study, we investigated the structure-dependent AhR activity of 14 flavonoids in Caco2 colon cancer cells using induction of CYP1A1 and UGT1A1 gene expression as endpoints.	Flavonoids	74-84	aryl hydrocarbon receptor	Homo sapiens	55-58
29584932-5	2018	The structure-dependent effects of the hydroxyl flavonoids on induction of UGT1A1 were similar to that observed for induction of CYP1A1 except that luteolin and apigenin induced UGT1A1 levels similar to that observed for TCDD, whereas both compounds were AhR antagonists for CYP1A1.	Flavonoids	48-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	75-81
29584932-6	2018	Thus, the effects of the flavonoids in Caco2 cells on Ah-responsiveness and interactions with butyrate were both ligand structure- and response-dependent and these activities are consistent with hydroxyflavonoids being selective AhR modulators.	Flavonoids	25-35	aryl hydrocarbon receptor	Homo sapiens	229-232
28745105-0	2018	Honey flavonoids inhibit hOATP2B1 and hOATP1A2 transporters and hOATP-mediated rosuvastatin cell uptake in vitro.	Flavonoids	6-16	solute carrier organic anion transporter family member 1A2	Homo sapiens	38-46
28745105-4	2018	This study is aimed at an evaluation of the inhibitory potency of selected food honey flavonoids (namely galangin, myricetin, pinocembrin, pinobanksin, chrysin and fisetin) toward hOATP2B1 and hOATP1A2 as well as at examining their effect on the cellular uptake of the known OATP substrate rosuvastatin.	Flavonoids	86-96	solute carrier organic anion transporter family member 2B1	Homo sapiens	180-188
28745105-4	2018	This study is aimed at an evaluation of the inhibitory potency of selected food honey flavonoids (namely galangin, myricetin, pinocembrin, pinobanksin, chrysin and fisetin) toward hOATP2B1 and hOATP1A2 as well as at examining their effect on the cellular uptake of the known OATP substrate rosuvastatin.	Flavonoids	86-96	solute carrier organic anion transporter family member 1A2	Homo sapiens	193-201
28745105-4	2018	This study is aimed at an evaluation of the inhibitory potency of selected food honey flavonoids (namely galangin, myricetin, pinocembrin, pinobanksin, chrysin and fisetin) toward hOATP2B1 and hOATP1A2 as well as at examining their effect on the cellular uptake of the known OATP substrate rosuvastatin.	Flavonoids	86-96	solute carrier organic anion transporter family member 1A2	Homo sapiens	181-185
28745105-6	2018	Cell lines overexpressing the hOATP2B1 or hOATP1A2 transporter were employed as in vitro model to determine the inhibitory potency of the flavonoids toward the OATPs.	Flavonoids	138-148	solute carrier organic anion transporter family member 2B1	Homo sapiens	30-38
31089549-2	2018	In this study, we investigated the effect of quercetin, a naturally occurring flavonoid, on UCP1 expression in white/brown adipose tissues (WAT/BAT).	Flavonoids	78-87	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	92-96
28745105-8	2018	Chrysin, galangin and pinocembrin were found to inhibit both hOATP2B1 and hOATP1A2 in lower or comparable concentrations as the known flavonoid OATP inhibitor quercetin.	Flavonoids	134-143	solute carrier organic anion transporter family member 2B1	Homo sapiens	61-69
28745105-8	2018	Chrysin, galangin and pinocembrin were found to inhibit both hOATP2B1 and hOATP1A2 in lower or comparable concentrations as the known flavonoid OATP inhibitor quercetin.	Flavonoids	134-143	solute carrier organic anion transporter family member 1A2	Homo sapiens	74-82
29953467-4	2018	Therefore, the interaction features of monomeric U-shape Abeta17-42 with natural flavonoids including myricetin, morin and flavone at different mole ratios were comprehensively studied to recognize the mechanism of Abeta monomer instability using molecular dynamics (MD) simulations.	Flavonoids	81-91	amyloid beta precursor protein	Homo sapiens	57-62
29953467-5	2018	We found that all flavonoids have tendency to interact and destabilize Abeta peptide structure with mole ratio-dependent effects.	Flavonoids	18-28	amyloid beta precursor protein	Homo sapiens	71-76
29915353-3	2018	A combined metabolomic and transcriptomic characterization of NO-deficient nia1,2noa1-2 mutant plants suggests that NO acts attenuating the production and accumulation of osmoprotective and regulatory metabolites, such as sugars and polyamines, stress-related hormones, such as ABA and jasmonates, and antioxidants, such as anthocyanins and flavonoids.	Flavonoids	341-351	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	81-85
29962921-10	2018	Several dietary constituents, namely flavonoid compounds, have demonstrated inhibitory effects on AhR activation.	Flavonoids	37-46	aryl hydrocarbon receptor	Homo sapiens	98-101
30050588-0	2018	Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1.	Flavonoids	0-9	sirtuin 1	Rattus norvegicus	117-122
29940863-10	2018	Complex genes MYB75, GL1 and flavonoid biosynthetic genes TT3 and TT18 in sk372 were all significantly enhanced.	Flavonoids	29-38	production of anthocyanin pigment 1	Arabidopsis thaliana	14-19
29940863-10	2018	Complex genes MYB75, GL1 and flavonoid biosynthetic genes TT3 and TT18 in sk372 were all significantly enhanced.	Flavonoids	29-38	dihydroflavonol 4-reductase	Arabidopsis thaliana	58-61
29940863-10	2018	Complex genes MYB75, GL1 and flavonoid biosynthetic genes TT3 and TT18 in sk372 were all significantly enhanced.	Flavonoids	29-38	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	66-70
29890751-0	2018	Correlation between the Potency of Flavonoids on Mushroom Tyrosinase Inhibitory Activity and Melanin Synthesis in Melanocytes.	Flavonoids	35-45	tyrosinase	Homo sapiens	58-68
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Flavonoids	14-24	interleukin 6	Homo sapiens	173-177
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Flavonoids	14-24	tumor necrosis factor	Homo sapiens	179-188
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Flavonoids	14-24	interleukin 1 alpha	Homo sapiens	190-198
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Flavonoids	14-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
29890751-5	2018	Studies on the correlation between the enzyme-based and cell-based assays showed that only the flavonoids with IC50 values below 50 muM against mushroom tyrosinase could inhibit the mammalian tyrosinase, and thus, reduce melanogenesis in B16-F10.	Flavonoids	95-105	latexin	Homo sapiens	132-135
29890751-5	2018	Studies on the correlation between the enzyme-based and cell-based assays showed that only the flavonoids with IC50 values below 50 muM against mushroom tyrosinase could inhibit the mammalian tyrosinase, and thus, reduce melanogenesis in B16-F10.	Flavonoids	95-105	tyrosinase	Homo sapiens	153-163
29890751-5	2018	Studies on the correlation between the enzyme-based and cell-based assays showed that only the flavonoids with IC50 values below 50 muM against mushroom tyrosinase could inhibit the mammalian tyrosinase, and thus, reduce melanogenesis in B16-F10.	Flavonoids	95-105	tyrosinase	Homo sapiens	192-202
29890751-6	2018	Flavonoids with the IC50 values greater than 50 muM, on the other hand, could not inhibit the mammalian tyrosinase, and had either no effect or enhancement of melanogenesis.	Flavonoids	0-10	latexin	Homo sapiens	48-51
29874868-8	2018	The flavonoids (-)-epigallocatechin (5) and (-)-epicatechin (6) exhibited prominent hepatoprotective activities with higher cell viability values (65.53% and 62.40% at 10 muM mL-1, respectively) than the positive control, silymarin (61.85% at 10 muM mL-1).	Flavonoids	4-14	L1 cell adhesion molecule	Mus musculus	175-179
29890650-0	2018	Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling.	Flavonoids	24-34	nuclear receptor subfamily 1, group H, member 4	Mus musculus	141-144
29874868-8	2018	The flavonoids (-)-epigallocatechin (5) and (-)-epicatechin (6) exhibited prominent hepatoprotective activities with higher cell viability values (65.53% and 62.40% at 10 muM mL-1, respectively) than the positive control, silymarin (61.85% at 10 muM mL-1).	Flavonoids	4-14	L1 cell adhesion molecule	Mus musculus	250-254
29548810-0	2018	Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids.	Flavonoids	88-98	solute carrier family 2 member 2	Homo sapiens	62-67
29548810-0	2018	Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids.	Flavonoids	88-98	solute carrier family 2 member 5	Homo sapiens	69-74
29548810-12	2018	Since GLUT2, GLUT5 and GLUT7 show different patterns of inhibition by the tested flavonoids, we suggest that they have the potential to be used as investigational tools to distinguish sugar transporter activity in different biological settings.	Flavonoids	81-91	solute carrier family 2 member 2	Homo sapiens	6-11
29548810-0	2018	Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids.	Flavonoids	88-98	solute carrier family 2 member 7	Homo sapiens	79-84
29548810-12	2018	Since GLUT2, GLUT5 and GLUT7 show different patterns of inhibition by the tested flavonoids, we suggest that they have the potential to be used as investigational tools to distinguish sugar transporter activity in different biological settings.	Flavonoids	81-91	solute carrier family 2 member 5	Homo sapiens	13-18
29548810-1	2018	Only limited data are available on the inhibition of the sugar transporter GLUT5 by flavonoids or other classes of bioactives.	Flavonoids	84-94	solute carrier family 2 member 5	Homo sapiens	75-80
29548810-12	2018	Since GLUT2, GLUT5 and GLUT7 show different patterns of inhibition by the tested flavonoids, we suggest that they have the potential to be used as investigational tools to distinguish sugar transporter activity in different biological settings.	Flavonoids	81-91	solute carrier family 2 member 7	Homo sapiens	23-28
28856926-0	2018	Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway.	Flavonoids	6-16	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
29427594-0	2018	Isoprenylated flavonoids from Morus nigra and their PPAR gamma agonistic activities.	Flavonoids	14-24	peroxisome proliferator activated receptor gamma	Homo sapiens	52-62
29512770-0	2018	Inhibition effects of total flavonoids from Sculellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway.	Flavonoids	28-38	parathyroid hormone like hormone	Homo sapiens	132-137
29892789-0	2018	Protective Effects of Foods Containing Flavonoids on Age-Related Cognitive Decline.	Flavonoids	39-49	renin binding protein	Homo sapiens	53-56
29892789-2	2018	We review recent research exploring the protective effects of flavonoids on age-related cognitive decline and neurodegenerative disorders in humans and animals.	Flavonoids	62-72	renin binding protein	Homo sapiens	76-79
29872532-2	2018	The abundance of different flavonoid compounds are finely tuned with species-specific pattern by a ternary MBW complex, which consists of a MYB, a bHLH, and a WD40 protein, but the essential role of SlAN11, which is a WD40 protein, is not fully understood in tomato until now.	Flavonoids	27-36	R2R3MYB transcription factor 14	Solanum lycopersicum	140-143
29872532-8	2018	These results suggest that the tomato WD40 protein SlAN11, coordinating with bHLH and MYB proteins, plays a crucial role in the fine adjustment of the flavonoid biosynthesis and seed dormancy in tomato.	Flavonoids	151-160	R2R3MYB transcription factor 14	Solanum lycopersicum	86-89
29425861-4	2018	5,7-Dimethoxyflavone (5,7-DMF) is a natural flavonoid which was recently reported to be a potent BCRP inhibitor.	Flavonoids	44-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	97-101
29843562-3	2018	In the present study, ADA inhibitory activity of morin, a bioactive flavonoid, was assessed through computational and biophysical methods.	Flavonoids	68-77	adenosine deaminase	Homo sapiens	22-25
29945392-13	2018	Compared with the model group, estrogen group increased the protein expression of ERalpha significantly(P&lt;0.001).TFS mid-dose group and TFS high-dose group is increased the protein expression of ERalpha(P&lt;0.01, P&lt;0.001).In a conclusion,Flavonoids is the main active ingredient of Astragali Complanati Semen.	Flavonoids	245-255	estrogen receptor 1	Rattus norvegicus	198-205
29117513-4	2018	This review discusses potential mechanisms of flavonoid action in the brain, with a focus on two critical transcription factors: cAMP response element-binding protein (CREB) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	Flavonoids	46-55	cAMP responsive element binding protein 1	Homo sapiens	129-166
29117513-4	2018	This review discusses potential mechanisms of flavonoid action in the brain, with a focus on two critical transcription factors: cAMP response element-binding protein (CREB) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	Flavonoids	46-55	cAMP responsive element binding protein 1	Homo sapiens	168-172
29117513-4	2018	This review discusses potential mechanisms of flavonoid action in the brain, with a focus on two critical transcription factors: cAMP response element-binding protein (CREB) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	Flavonoids	46-55	nuclear factor kappa B subunit 1	Homo sapiens	242-251
29770817-5	2018	The cellular thermal shift assay (CETSA) and notably competitive binding assay by the microscale thermophoresis (MST) method provided the evidence that this flavonoid directly bound to BCL-2.	Flavonoids	157-166	BCL2 apoptosis regulator	Homo sapiens	185-190
29783993-3	2018	Despite this fact, the antiviral properties of CST, one of such flavonoids, against the influenza virus has not been reported.	Flavonoids	64-74	cystatin 12, pseudogene	Homo sapiens	47-50
29951107-4	2018	Total flavonoids isolated from RG (TFRG) exhibited anti-inflammatory activity through the regulation of ERK/NF-kappaB/miR-155 signaling and suppression of iNOS expression in LPS/IFN-gamma stimulated RAW264.7 macrophages without cytotoxicity.	Flavonoids	6-16	mitogen-activated protein kinase 1	Homo sapiens	104-107
29951107-4	2018	Total flavonoids isolated from RG (TFRG) exhibited anti-inflammatory activity through the regulation of ERK/NF-kappaB/miR-155 signaling and suppression of iNOS expression in LPS/IFN-gamma stimulated RAW264.7 macrophages without cytotoxicity.	Flavonoids	6-16	nuclear factor kappa B subunit 1	Homo sapiens	108-117
29951107-4	2018	Total flavonoids isolated from RG (TFRG) exhibited anti-inflammatory activity through the regulation of ERK/NF-kappaB/miR-155 signaling and suppression of iNOS expression in LPS/IFN-gamma stimulated RAW264.7 macrophages without cytotoxicity.	Flavonoids	6-16	microRNA 155	Homo sapiens	118-125
29951107-4	2018	Total flavonoids isolated from RG (TFRG) exhibited anti-inflammatory activity through the regulation of ERK/NF-kappaB/miR-155 signaling and suppression of iNOS expression in LPS/IFN-gamma stimulated RAW264.7 macrophages without cytotoxicity.	Flavonoids	6-16	nitric oxide synthase 2	Homo sapiens	155-159
29951107-4	2018	Total flavonoids isolated from RG (TFRG) exhibited anti-inflammatory activity through the regulation of ERK/NF-kappaB/miR-155 signaling and suppression of iNOS expression in LPS/IFN-gamma stimulated RAW264.7 macrophages without cytotoxicity.	Flavonoids	6-16	interferon gamma	Homo sapiens	178-187
29951107-0	2018	Total Flavonoids from Radix Glycyrrhiza Exert Anti-Inflammatory and Antitumorigenic Effects by Inactivating iNOS Signaling Pathways.	Flavonoids	6-16	nitric oxide synthase 2	Homo sapiens	108-112
29708335-3	2018	In this study, we showed that quercetin inhibited MPO-mediated HOCl formation (75.0 +- 6.2% for 10 muM quercetin versus 100 +- 5.2% for control group, P &lt; 0.01) and cytotoxicity to endothelial cells in vitro, while this flavonoid was nontoxic to endothelial cell cultures ( P &gt; 0.05, all cases).	Flavonoids	223-232	myeloperoxidase	Homo sapiens	50-53
29685682-1	2018	4-Coumaroyl-CoA ligase (4CL) is ubiquitous in the plant kingdom, and plays a central role in the biosynthesis of phenylpropanoids such as lignins, flavonoids, and coumarins.	Flavonoids	147-157	4-coumarate--CoA ligase-like 7-like	Glycine max	0-22
29685682-1	2018	4-Coumaroyl-CoA ligase (4CL) is ubiquitous in the plant kingdom, and plays a central role in the biosynthesis of phenylpropanoids such as lignins, flavonoids, and coumarins.	Flavonoids	147-157	4-coumarate--CoA ligase-like 7-like	Glycine max	24-27
29895495-0	2018	Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models.	Flavonoids	0-10	negative elongation factor complex member C/D	Homo sapiens	14-17
29895495-3	2018	PURPOSE: This systematic review focuses on various classes of flavonoids with a view to evaluate whether Th1/Th2 cytokine-mediated pathways of immunoenhancement could reduce immune overwhelming reactions.	Flavonoids	62-72	negative elongation factor complex member C/D	Homo sapiens	105-108
29895495-6	2018	Ten articles described the effect of flavonoids on allergic inflammation in an animal model of asthma; eleven in vivo studies evaluated the immunomodulating and immunosuppressive effects of flavonoids on Th1/Th2 cytokines production and five reports described the regulatory role of flavonoids for Th1/Th2 cytokine responses to experimental arthritis and myocarditis.	Flavonoids	190-200	negative elongation factor complex member C/D	Homo sapiens	204-207
29895495-6	2018	Ten articles described the effect of flavonoids on allergic inflammation in an animal model of asthma; eleven in vivo studies evaluated the immunomodulating and immunosuppressive effects of flavonoids on Th1/Th2 cytokines production and five reports described the regulatory role of flavonoids for Th1/Th2 cytokine responses to experimental arthritis and myocarditis.	Flavonoids	190-200	negative elongation factor complex member C/D	Homo sapiens	204-207
29895495-8	2018	CONCLUSION: Naturally occurring flavonoids discussed in the present article have optimal immunomodulation to prevent immune-mediated disorders through management of Th1/Th2 cytokine balance.	Flavonoids	32-42	negative elongation factor complex member C/D	Homo sapiens	165-168
29861773-0	2018	The Flavonoid Jaceosidin from Artemisia princeps Induces Apoptotic Cell Death and Inhibits the Akt Pathway in Oral Cancer Cells.	Flavonoids	4-13	AKT serine/threonine kinase 1	Homo sapiens	95-98
29140707-0	2018	Grapefruit Flavonoid Naringenin Regulates the Expression of LXRalpha in THP-1 Macrophages by Modulating AMP-Activated Protein Kinase.	Flavonoids	11-20	nuclear receptor subfamily 1 group H member 3	Homo sapiens	60-68
29140707-0	2018	Grapefruit Flavonoid Naringenin Regulates the Expression of LXRalpha in THP-1 Macrophages by Modulating AMP-Activated Protein Kinase.	Flavonoids	11-20	GLI family zinc finger 2	Homo sapiens	72-77
29140707-5	2018	Treatments with this flavonoid also inhibited cell migration in THP-1 cells.	Flavonoids	21-30	GLI family zinc finger 2	Homo sapiens	64-69
29635895-0	2018	Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects.	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
29481523-0	2018	Flavonoids extracted from leaves of Diospyros kaki regulates RhoA activity to rescue synapse loss and reverse memory impairment in APP/PS1 mice.	Flavonoids	0-10	ras homolog family member A	Mus musculus	61-65
29481523-0	2018	Flavonoids extracted from leaves of Diospyros kaki regulates RhoA activity to rescue synapse loss and reverse memory impairment in APP/PS1 mice.	Flavonoids	0-10	presenilin 1	Mus musculus	135-138
29736333-0	2018	From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel.	Flavonoids	45-54	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	88-94
29736333-4	2018	Due to the medical use of flavonoids, a considerable increase in studies on their influence on human health has recently been observed, therefore our aim is to study, through computational methods, the three-dimensional (3D) conformation together with mechanism of action of Kir6.1 with three flavonoids.	Flavonoids	26-36	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	275-281
29736333-4	2018	Due to the medical use of flavonoids, a considerable increase in studies on their influence on human health has recently been observed, therefore our aim is to study, through computational methods, the three-dimensional (3D) conformation together with mechanism of action of Kir6.1 with three flavonoids.	Flavonoids	293-303	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	275-281
29736333-8	2018	Conclusion: Combined methodological approaches, such as molecular modelling, docking and MD simulations of Kir6.1 channel, used to elucidate flavonoids intrinsic mechanism of action, are introduced, revealing a new potential druggable protein site.	Flavonoids	141-151	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	107-113
29635895-8	2018	This review deals with various plant-derived flavonoids, their preclinical potential as AChE inhibitors, in established assays, possible mechanisms of action, and structural activity relationship (SAR).	Flavonoids	45-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	88-92
29635895-9	2018	RESULTS AND CONCLUSIONS: Subsequently, a number of plant-derived flavonoids with outstanding efficacy and potency as AChE inhibitors, the mechanistic, their safety profiles, and pharmacokinetic attributes have been discussed.	Flavonoids	65-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	117-121
29921368-0	2018	Time to look past TNF and thalidomide for cachexia - could mast cells and flavonoids be the answer?	Flavonoids	74-84	tumor necrosis factor	Homo sapiens	18-21
29676183-0	2018	Synthesis &amp; alpha-glucosidase inhibitory &amp; glucose consumption-promoting activities of flavonoid-coumarin hybrids.	Flavonoids	95-104	sucrase-isomaltase	Homo sapiens	16-33
29178427-8	2018	When CD38-generated cADPR was restrained by 8-Br-cADPR or kuromanin, a flavonoid known to inhibit CD38 enzymatic activity, RSV-induced type I/III IFNs and ISGs were markedly reduced.	Flavonoids	71-80	CD38 molecule	Homo sapiens	5-9
29178427-8	2018	When CD38-generated cADPR was restrained by 8-Br-cADPR or kuromanin, a flavonoid known to inhibit CD38 enzymatic activity, RSV-induced type I/III IFNs and ISGs were markedly reduced.	Flavonoids	71-80	CD38 molecule	Homo sapiens	98-102
29735017-1	2018	Flavonoids upregulate gene expression of PPAR-alpha and underregulate the gene expression of SREBP-1c, and their intake increases the plasmatic concentration of n-3 LC-PUFAs.	Flavonoids	0-10	peroxisome proliferator activated receptor alpha	Rattus norvegicus	41-51
29396908-3	2018	Using cultured hepatocytes, we previously showed that the plant flavonoid quercetin-3-glucoside (Q3G) inhibits PCSK9 secretion, stimulated LDLR expression, and enhanced LDL-C uptake.	Flavonoids	64-73	proprotein convertase subtilisin/kexin type 9	Mus musculus	111-116
29396908-3	2018	Using cultured hepatocytes, we previously showed that the plant flavonoid quercetin-3-glucoside (Q3G) inhibits PCSK9 secretion, stimulated LDLR expression, and enhanced LDL-C uptake.	Flavonoids	64-73	low density lipoprotein receptor	Mus musculus	139-143
29396908-3	2018	Using cultured hepatocytes, we previously showed that the plant flavonoid quercetin-3-glucoside (Q3G) inhibits PCSK9 secretion, stimulated LDLR expression, and enhanced LDL-C uptake.	Flavonoids	64-73	component of oligomeric golgi complex 2	Mus musculus	169-174
29715320-0	2018	Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex.	Flavonoids	36-46	cyclin dependent kinase 6	Homo sapiens	54-79
29675814-4	2018	Furthermore, we found that the transcript level of ZINC FINGER of ARABIDOPSIS THALIANA 6 (ZAT6) was significantly activated after exogenous H2O2 treatment, and modulation of AtZAT6 expression positively affected the concentrations of both anthocyanin and total flavonoids.	Flavonoids	261-271	6	Arabidopsis thaliana	90-94
29735017-1	2018	Flavonoids upregulate gene expression of PPAR-alpha and underregulate the gene expression of SREBP-1c, and their intake increases the plasmatic concentration of n-3 LC-PUFAs.	Flavonoids	0-10	sterol regulatory element binding transcription factor 1	Rattus norvegicus	93-101
29675814-4	2018	Furthermore, we found that the transcript level of ZINC FINGER of ARABIDOPSIS THALIANA 6 (ZAT6) was significantly activated after exogenous H2O2 treatment, and modulation of AtZAT6 expression positively affected the concentrations of both anthocyanin and total flavonoids.	Flavonoids	261-271	6	Arabidopsis thaliana	174-180
29715320-1	2018	Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6.	Flavonoids	0-10	cyclin dependent kinase 6	Homo sapiens	177-181
29715320-3	2018	The binding efficiencies of flavonoids against the CDK6/cyclin D complex were mainly through the electrostatic (especially the H-bond force) and vdW interactions with residues ILE19, VAL27, ALA41, GLU61, PHE98, GLN103, ASP163 and LEU152.	Flavonoids	28-38	cyclin dependent kinase 6	Homo sapiens	51-55
29715320-4	2018	The order of binding affinities of these flavonoids toward the CDK6/cyclin D was M03 &gt; M01 &gt; M07 &gt; M15 &gt; M06 &gt; M05 &gt; M04.	Flavonoids	41-51	cyclin dependent kinase 6	Homo sapiens	63-67
29715320-5	2018	It is anticipated that the binding features of flavonoid inhibitors studied in the present work may provide valuable insights for the development of CDK6 inhibitors.	Flavonoids	47-56	cyclin dependent kinase 6	Homo sapiens	149-153
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	Flavonoids	78-88	peroxisome proliferator activated receptor alpha	Mus musculus	28-33
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	Flavonoids	78-88	estrogen receptor 1 (alpha)	Mus musculus	15-19
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	Flavonoids	78-88	peroxisome proliferator activated receptor gamma	Mus musculus	35-40
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	Flavonoids	78-88	prostaglandin-endoperoxide synthase 2	Mus musculus	21-26
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	Flavonoids	78-88	prostaglandin-endoperoxide synthase 1	Mus musculus	42-47
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	Flavonoids	78-88	carbonic anhydrase 2	Mus musculus	52-55
29703389-7	2018	For example, studies showed that repeated administration of flavonoids causes down-regulation of cytochrome P450 enzymes and up-regulation of uridine diphosphate glucuronosyltransferases (UGT).	Flavonoids	60-70	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	142-186
29589006-0	2018	Pretreatment with dihydroquercetin, a dietary flavonoid, protected against concanavalin A-induced immunological hepatic injury in mice and TNF-alpha/ActD-induced apoptosis in HepG2 cells.	Flavonoids	46-55	tumor necrosis factor	Mus musculus	139-148
29652826-2	2018	We aimed to explore the effects of microbial metabolites common to anthocyanins and other flavonoids on vascular smooth muscle heme oxygenase-1 (HO-1) expression.	Flavonoids	90-100	heme oxygenase 1	Homo sapiens	127-143
29652826-2	2018	We aimed to explore the effects of microbial metabolites common to anthocyanins and other flavonoids on vascular smooth muscle heme oxygenase-1 (HO-1) expression.	Flavonoids	90-100	heme oxygenase 1	Homo sapiens	145-149
29632297-11	2018	CONCLUSIONS Baicalin, a flavonoid used in Chinese herbal medicine, inhibited the proliferation and migration of human NSCLC cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway.	Flavonoids	24-33	sirtuin 1	Homo sapiens	165-170
30607321-4	2018	Molecular docking and free energy calculations were carried out to examine the binding of these flavonoids to the ATP-binding site and editing domain of DNA gyrase and Isoleucyl-tRNA synthetase, respectively.	Flavonoids	96-106	DNA topoisomerase II alpha	Homo sapiens	153-163
30607321-4	2018	Molecular docking and free energy calculations were carried out to examine the binding of these flavonoids to the ATP-binding site and editing domain of DNA gyrase and Isoleucyl-tRNA synthetase, respectively.	Flavonoids	96-106	isoleucyl-tRNA synthetase 1	Homo sapiens	168-193
29421708-0	2018	Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2.	Flavonoids	64-74	carboxylesterase 2	Homo sapiens	103-121
29421708-4	2018	In this study, more than fifty flavonoids were collected to assay their inhibitory effects against hCE2 using a fluorescence-based method.	Flavonoids	31-41	carboxylesterase 2	Homo sapiens	99-103
29421708-6	2018	Among all tested flavonoids, 5,6-dihydroxyflavone displayed the most potent inhibitory effect against hCE2 with the IC50 value of 3.50 muM.	Flavonoids	17-27	carboxylesterase 2	Homo sapiens	102-106
29421708-8	2018	All these findings are very helpful for the medicinal chemists to design and develop more potent and highly selective flavonoid-type hCE2 inhibitors.	Flavonoids	118-127	carboxylesterase 2	Homo sapiens	133-137
29339110-4	2018	On HepG2 cells Insulin EC50 of 93 +- 21nM decreased to 13 +- 2nM in the presence of the flavonoids mixture from A.cominia.	Flavonoids	88-98	insulin	Homo sapiens	15-22
29339110-5	2018	In L6 cells, insulin also produced a concentration-dependent increase with an EC50 of 28.6 +- 0.7nM; EC50 decreased to 0.08 +- 0.02nM and 5 +- 0.9nM in the presence of 100mug/ml of flavonoids and pheophytins mixtures, respectively.	Flavonoids	181-191	insulin	Homo sapiens	13-20
29339110-6	2018	In 3T3-L1 fibroblasts, insulin had an EC50 of &gt;1000nM that decreased to 38 +- 4nM in the presence of the flavonoids extract.	Flavonoids	108-118	insulin	Homo sapiens	23-30
29548824-8	2018	Furthermore, a metabolomics analysis using LC-MS revealed changes in flavonoid profile in the pap1-1 and tt3 plants, which established a causal relationship between plant adaptation to low N stress and these compounds including anthocyanins.	Flavonoids	69-78	purple acid phosphatase 11	Arabidopsis thaliana	94-100
29625607-6	2018	RESULTS: AEAC containing flavonoids, phenols, saponins and protodioscin induced enhancement of NGF secretion and decreased intracellular ROS in the neuronal and microglial cell line.	Flavonoids	25-35	nerve growth factor	Mus musculus	95-98
29553750-1	2018	As two key steps, the coupling via a boron-mediated aldol condensation and the cyclization via a highly stereoselective intramolecular Michael addition of 1,3-diketone proceed under mild conditions; thus, the chiral flavonoids bearing C-7 oxy functional groups or olefinic bonds are both easily accessible.	Flavonoids	216-226	complement C7	Homo sapiens	235-238
29703389-7	2018	For example, studies showed that repeated administration of flavonoids causes down-regulation of cytochrome P450 enzymes and up-regulation of uridine diphosphate glucuronosyltransferases (UGT).	Flavonoids	60-70	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	188-191
29425740-3	2018	Since 11beta-hydroxysteroid dehydrogenases (HSD11Bs) play important roles in diabetes, we hypothesize that flavonoids and isoflavonoids may affect diabetes by targeting two isoforms of HSD11B differently.	Flavonoids	107-117	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	44-50
29437915-0	2018	CYP4X1 Inhibition by Flavonoid CH625 Normalizes Glioma Vasculature through Reprogramming TAMs via CB2 and EGFR-STAT3 Axis.	Flavonoids	21-30	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	0-6
29437915-0	2018	CYP4X1 Inhibition by Flavonoid CH625 Normalizes Glioma Vasculature through Reprogramming TAMs via CB2 and EGFR-STAT3 Axis.	Flavonoids	21-30	cannabinoid receptor 2	Homo sapiens	98-101
29437915-0	2018	CYP4X1 Inhibition by Flavonoid CH625 Normalizes Glioma Vasculature through Reprogramming TAMs via CB2 and EGFR-STAT3 Axis.	Flavonoids	21-30	epidermal growth factor receptor	Homo sapiens	106-110
29437915-0	2018	CYP4X1 Inhibition by Flavonoid CH625 Normalizes Glioma Vasculature through Reprogramming TAMs via CB2 and EGFR-STAT3 Axis.	Flavonoids	21-30	signal transducer and activator of transcription 3	Homo sapiens	111-116
29437915-2	2018	Here, we tested whether CYP4X1 inhibition in TAMs by flavonoid CH625 prolongs survival and normalizes glioma vasculature.	Flavonoids	53-62	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	24-30
29425740-8	2018	The effective flavonoids and isoflavonoids are noncompetitive inhibitors of HSD11B1 when steroid substrates were used.	Flavonoids	14-24	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	76-83
29597321-4	2018	NtMYB2 belongs to subgroup 4 of the R2R3 MYB transcription factor family that are related to repressor MYBs involved in the regulation of anthocyanin and flavonoids.	Flavonoids	154-164	uncharacterized protein LOC107775040	Nicotiana tabacum	2-5
29593542-8	2018	Both flavonoids suppressed pro-intravasative trigger factors in MDA-MB231 breast cancer cells, specifically MMP1 expression and CYP1A1 activity.	Flavonoids	5-15	matrix metallopeptidase 1	Homo sapiens	108-112
29258854-6	2018	Eight flavonoids were isolated from JFE, and of those, cupressuflavone and isoscutellarein-7-O-beta-xylopyranoside strongly down-regulated IL-4 expression and beta-hexosaminidase release in RBL-2H3 cells.	Flavonoids	6-16	interleukin 4	Mus musculus	139-143
29258854-6	2018	Eight flavonoids were isolated from JFE, and of those, cupressuflavone and isoscutellarein-7-O-beta-xylopyranoside strongly down-regulated IL-4 expression and beta-hexosaminidase release in RBL-2H3 cells.	Flavonoids	6-16	RB transcriptional corepressor like 2	Rattus norvegicus	190-195
29744232-5	2018	The ACE results showed that gallic acids and six flavonoid compounds had relative strong interactions with thrombin.	Flavonoids	49-58	coagulation factor II, thrombin	Homo sapiens	107-115
29744232-6	2018	In addition, the docking results indicated that all of optimal conformations of the six flavonoid compounds were positioned into the thrombin activity centre and had interaction with the HIS57 or SER195 which was the key residue to bind thrombin inhibitors such as argatroban.	Flavonoids	88-97	coagulation factor II, thrombin	Homo sapiens	133-141
29744232-6	2018	In addition, the docking results indicated that all of optimal conformations of the six flavonoid compounds were positioned into the thrombin activity centre and had interaction with the HIS57 or SER195 which was the key residue to bind thrombin inhibitors such as argatroban.	Flavonoids	88-97	coagulation factor II, thrombin	Homo sapiens	237-245
29744232-7	2018	Herein, these six flavonoid compounds might have the potential of thrombin inhibition activity.	Flavonoids	18-27	coagulation factor II, thrombin	Homo sapiens	66-74
29593542-8	2018	Both flavonoids suppressed pro-intravasative trigger factors in MDA-MB231 breast cancer cells, specifically MMP1 expression and CYP1A1 activity.	Flavonoids	5-15	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	128-134
29515203-5	2018	Here we show, that flavonoids can alter SIRT6 activity in a structure dependent manner.	Flavonoids	19-29	sirtuin 6	Homo sapiens	40-45
29693024-3	2018	Several studies attempted to investigate the role of various flavonoids mainly in experimental models of autoimmune diseases, especially in the context of their potential effect on the increase of regulatory T cells (Tregs) and their ability to stimulate an overexpression of anti-inflammatory cytokines, in particular that of IL-10.	Flavonoids	61-71	interleukin 10	Homo sapiens	327-332
29693024-4	2018	The emergence of IL-17, a cytokine largely produced by Th17 cells, as a powerful proinflammatory stimulus which attenuates the induction of Tregs has prompted a series of studies investigating the role of flavonoids on Th17 cells in experimental models as well as human autoimmune diseases.	Flavonoids	205-215	interleukin 17A	Homo sapiens	17-22
29692648-0	2018	Effects of different components of Mao Dongqing"s total flavonoids and total saponins on transient ischemic attack (TIA) model of rats.	Flavonoids	56-66	monoamine oxidase A	Rattus norvegicus	35-38
29108086-7	2018	RESULTS: All tested flavonoids act as free radicals scavengers (ROO  and NO ) and advanced glycation end products inhibitors, in agreement with their BDE, IP and molecular planarity.	Flavonoids	20-30	homeobox D13	Homo sapiens	150-153
29285772-0	2018	Computational and experimental exploration of the structure-activity relationships of flavonoids as potent glyoxalase-I inhibitors.	Flavonoids	86-96	glyoxalase I	Homo sapiens	107-119
29285772-2	2018	Several classes of natural products including coumarins and flavonoids have shown remarkable Glo-I inhibitory activity.	Flavonoids	60-70	glyoxalase I	Homo sapiens	93-98
29285772-3	2018	In the present study, computational and experimental approaches were used to explore the structure-activity relationships of a panel of 24 flavonoids as inhibitors of the Glo-1 enzyme.	Flavonoids	139-149	glyoxalase I	Homo sapiens	171-176
29285772-7	2018	The structure-activity relationships revealed in this study had deepened our understanding of the Glo-I inhibitory activities of flavonoids and opened the door for further exploration of this promising compound class.	Flavonoids	129-139	glyoxalase I	Homo sapiens	98-103
29433224-7	2018	The CUV of some flavonoids were significantly (p&lt;0.05 or p&lt;0.01) higher than their CU, suggesting that specific flavonoids are pumped out by P-gp.	Flavonoids	16-26	ATP binding cassette subfamily B member 1	Homo sapiens	147-151
29433224-7	2018	The CUV of some flavonoids were significantly (p&lt;0.05 or p&lt;0.01) higher than their CU, suggesting that specific flavonoids are pumped out by P-gp.	Flavonoids	118-128	ATP binding cassette subfamily B member 1	Homo sapiens	147-151
29433224-8	2018	The structure-affinity relationship of flavonoids as substrates of P-gp was determined with the presence of 4"-OCH3, 3"-OCH3 and the absence of 3"-OH, 3-OH and 4"-OH favorable for the affinity of flavonoids.	Flavonoids	39-49	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
29433224-8	2018	The structure-affinity relationship of flavonoids as substrates of P-gp was determined with the presence of 4"-OCH3, 3"-OCH3 and the absence of 3"-OH, 3-OH and 4"-OH favorable for the affinity of flavonoids.	Flavonoids	196-206	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
29328481-1	2018	TTF1-NP is a flavonoid nanoparticle based on 5,2",4"-trihydroxy-6,7,5"-trimethoxyflavone (TTF1), which is derived from the medicinal plant Sorbaria sorbifolia that grows in the Changbai Mountain.	Flavonoids	13-22	transcription termination factor 1	Homo sapiens	0-4
29328481-1	2018	TTF1-NP is a flavonoid nanoparticle based on 5,2",4"-trihydroxy-6,7,5"-trimethoxyflavone (TTF1), which is derived from the medicinal plant Sorbaria sorbifolia that grows in the Changbai Mountain.	Flavonoids	13-22	transcription termination factor 1	Homo sapiens	90-94
29692648-4	2018	Results: The contents of total flavonoids and total saponins in the active part of Mao Dongqing can significantly improve the pathological changes of brain tissue in rats, improve the activity of Na+-K+-ATP enzyme, Ca++-ATP enzyme and Mg++-ATP enzyme in the brain of rats, and reduce the level of glutamic acid in serum.	Flavonoids	31-41	monoamine oxidase A	Rattus norvegicus	83-86
29692648-6	2018	CONCLUSION: The different proportions of total flavonoids and total saponins in the active part of Mao Dongqing all has a better effect on the rats with TIA, and the ratio of 10:6 is the best active component for preventing and controlling TIA.	Flavonoids	47-57	monoamine oxidase A	Rattus norvegicus	99-102
29480373-4	2018	Flavonoids were selected as a starting point based on their known COX-2 inhibitory and TP receptor antagonist activity.	Flavonoids	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-71
29681968-7	2018	By using LC-MS/MS analysis, one of the NGF binding fractions was enriched, which was further identified as quercetin, a major flavonoid in Ginkgo Folium.	Flavonoids	126-135	nerve growth factor	Rattus norvegicus	39-42
29535608-11	2018	We have shown for the first time that the activation of GPR30 could be one way for estrogen or flavonoids, possessing estrogenic properties, to enhance cholinergic functions in the brain, which could be a good candidate for possible treatment of neurodegenerative diseases.	Flavonoids	95-105	G protein-coupled estrogen receptor 1	Rattus norvegicus	56-61
29491681-4	2018	Flavonoids can have natural immunosuppressive properties and inhibit the activation of immune cells and its effectors (chemokines, TNF-, cytokines).	Flavonoids	0-10	tumor necrosis factor	Homo sapiens	131-134
29491681-5	2018	Phytochemicals such as flavonoids bind to the nuclear Ah (aryl hydrocarbon) -receptor thereby stimulating protective enzyme activities.	Flavonoids	23-33	aryl hydrocarbon receptor	Homo sapiens	58-85
29491681-9	2018	Flavonoids interact with toll-like receptors expressing on the surface of immune cells, then they were internalized to the cytosol and transferred into the nucleus, where they were attached to the Ah-receptor.	Flavonoids	0-10	aryl hydrocarbon receptor	Homo sapiens	197-208
29253187-0	2018	The GhmiR157a-GhSPL10 regulatory module controls initial cellular dedifferentiation and callus proliferation in cotton by modulating ethylene-mediated flavonoid biosynthesis.	Flavonoids	151-160	squamosa promoter-binding-like protein 7	Gossypium hirsutum	14-21
29253187-5	2018	We show that overexpression of GhSPL10, a target of GhmiR157a, increases free auxin and ethylene content and expression of associated signaling pathways, activates the flavonoid biosynthesis pathway, and promotes initial cellular dedifferentiation and callus proliferation.	Flavonoids	168-177	squamosa promoter-binding-like protein 7	Gossypium hirsutum	31-38
29253187-6	2018	Inhibition of expression of the flavonoid synthesis gene F3H in GhSPL10 overexpression lines (35S:rSPL10-7) blocked callus initiation, while exogenous application of several types of flavonol promoted callus proliferation, associated with cell cycle-related gene expression.	Flavonoids	32-41	squamosa promoter-binding-like protein 7	Gossypium hirsutum	64-71
29253187-8	2018	These results show that an up-regulation of ethylene signaling and the activation of flavonoid biosynthesis in GhSPL10 overexpression lines were associated with initial cellular dedifferentiation and callus proliferation.	Flavonoids	85-94	squamosa promoter-binding-like protein 7	Gossypium hirsutum	111-118
29253187-9	2018	Our results demonstrate the importance of a GhmiR157a-GhSPL10 gene module in regulating somatic embryogenesis via hormonal and flavonoid pathways.	Flavonoids	127-136	squamosa promoter-binding-like protein 7	Gossypium hirsutum	54-61
28562777-10	2018	For flavonoids, the highest values occurred in the treatments Gln30, Gln60 and MS1/2 and the lowest in Gln5, Gln10 and MS.	Flavonoids	4-14	MS	Homo sapiens	79-84
29443922-11	2018	Meanwhile, cranberry flavonoids supplementation promotes an anti-oxidant effect that may facilitate the post-exercise expression of hepcidin.	Flavonoids	21-31	hepcidin antimicrobial peptide	Homo sapiens	132-140
29274587-0	2018	Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury.	Flavonoids	34-44	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
29422671-5	2018	This compromises recruitment of TTG1 to the GLABRA2 locus and downregulates GLABRA2 expression, which enhances biosynthesis of fatty acids in the embryo, but reduces production of mucilage and flavonoid pigments in the seed coat.	Flavonoids	193-202	HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein	Arabidopsis thaliana	76-83
29450114-0	2018	Flavonoid-rich extract of Chromolaena odorata modulate circulating GLP-1 in Wistar rats: computational evaluation of TGR5 involvement.	Flavonoids	0-9	G protein-coupled bile acid receptor 1	Rattus norvegicus	117-121
29450114-7	2018	CONCLUSIONS: The results of this study support that C. odorata flavonoids may modulate the expression of GLP-1 and its release via TGR5.	Flavonoids	63-73	G protein-coupled bile acid receptor 1	Rattus norvegicus	131-135
29258018-3	2018	Flavonoids with AChE inhibitory activities and low toxicity are used to developing new anti-AD agents.	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-20
29288757-7	2018	In this review, the possible mechanistic effect of flavonoid-rich natural products on insulin resistance-related metabolic pathways is discussed.	Flavonoids	51-60	insulin	Homo sapiens	86-93
28455626-5	2018	It is possible to delay the age-related decline in testosterone production by increasing Star and/or Cyp11a1 gene expression using supplementation with flavonoids, a group of polyphenolic compounds widely distributed in fruits and vegetables.	Flavonoids	152-162	steroidogenic acute regulatory protein	Mus musculus	89-93
28455626-5	2018	It is possible to delay the age-related decline in testosterone production by increasing Star and/or Cyp11a1 gene expression using supplementation with flavonoids, a group of polyphenolic compounds widely distributed in fruits and vegetables.	Flavonoids	152-162	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	101-108
29434799-0	2018	Inhibition of X-linked inhibitor of apoptosis protein enhances anti-tumor potency of pure total flavonoids on the growth of leukemic cells.	Flavonoids	96-106	X-linked inhibitor of apoptosis	Homo sapiens	14-53
29284135-4	2018	Our results showed that MUD 1 presented the highest (P &lt; .05) fiber, protein, carbohydrate, polyphenol and flavonoid concentration, as well as the highest (P &lt; .05) total antioxidant capacity than the MUD 2 samples.	Flavonoids	110-119	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	24-29
29258000-0	2018	A prenylated flavonoid, 10-oxomornigrol F, exhibits anti-inflammatory effects by activating the Nrf2/heme oxygenase-1 pathway in macrophage cells.	Flavonoids	13-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
29127880-4	2018	Ang II significantly reduced the miR-145 compared with the control VSMC groups; all the tested flavonoids increased miR-145 in the 100 nM concentration.	Flavonoids	95-105	microRNA 145	Homo sapiens	116-123
29127880-0	2018	Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo.	Flavonoids	11-21	microRNA 145	Homo sapiens	25-37
29127880-0	2018	Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo.	Flavonoids	11-21	Kruppel like factor 4	Homo sapiens	57-61
29127880-0	2018	Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo.	Flavonoids	11-21	myocardin	Homo sapiens	66-75
29127880-3	2018	The aims of this study is designed to evaluate the atheroprotective effects on angiotensin II (Ang II)-induced miR-145 and Klf4/myocardin expression in vitro and in vivo of flavonoids, including (-)-epigallocatechin gallate (EGCG), chrysin, wogonin, silibinin, and ferulic acid.	Flavonoids	173-183	angiotensinogen	Homo sapiens	79-93
29127880-3	2018	The aims of this study is designed to evaluate the atheroprotective effects on angiotensin II (Ang II)-induced miR-145 and Klf4/myocardin expression in vitro and in vivo of flavonoids, including (-)-epigallocatechin gallate (EGCG), chrysin, wogonin, silibinin, and ferulic acid.	Flavonoids	173-183	angiotensinogen	Homo sapiens	95-101
29258000-0	2018	A prenylated flavonoid, 10-oxomornigrol F, exhibits anti-inflammatory effects by activating the Nrf2/heme oxygenase-1 pathway in macrophage cells.	Flavonoids	13-22	heme oxygenase 1	Mus musculus	101-117
28847709-2	2018	Natural flavonoids reduce pathological hallmarks, extracellular amyloid deposits and neurofibrillary tangles by mediating amyloid precursor protein (APP) processing, Abeta accumulation and tau pathology.	Flavonoids	8-18	microtubule associated protein tau	Homo sapiens	189-192
28847709-4	2018	Recently, some flavonoids were shown to inhibit poly (ADP-ribose) polymerases (PARPs) and cyclic ADP-ribose (cADP) synthases (CD38 and CD157), elevate intracellular nicotinamide adenine dinucleotide+ (NAD+) levels and activate NAD+ dependent sirtuin -mediated signaling pathways.	Flavonoids	15-25	CD38 molecule	Homo sapiens	126-130
28847709-4	2018	Recently, some flavonoids were shown to inhibit poly (ADP-ribose) polymerases (PARPs) and cyclic ADP-ribose (cADP) synthases (CD38 and CD157), elevate intracellular nicotinamide adenine dinucleotide+ (NAD+) levels and activate NAD+ dependent sirtuin -mediated signaling pathways.	Flavonoids	15-25	bone marrow stromal cell antigen 1	Homo sapiens	135-140
29496172-0	2018	Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants.	Flavonoids	49-59	monoamine oxidase A	Homo sapiens	20-45
29172480-5	2018	We have screened a set of small molecules to target this transcript and found Myricetin, a flavonoid, as a lead molecule that interacts with the CAG motif and thus prevents the translation of mutant huntingtin protein as well as sequestration of MBNL1.	Flavonoids	91-100	huntingtin	Mus musculus	199-209
29382339-0	2018	The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways.	Flavonoids	4-13	matrix metallopeptidase 9	Mus musculus	73-105
29600620-2	2018	In this study, hesperidin, diosmin, didymin and buddleoside were selected as flavonoids index components of mint, and the QAMS method was established to measure the contents of these flavonoids in mint.	Flavonoids	77-87	spen family transcriptional repressor	Homo sapiens	108-112
29600620-2	2018	In this study, hesperidin, diosmin, didymin and buddleoside were selected as flavonoids index components of mint, and the QAMS method was established to measure the contents of these flavonoids in mint.	Flavonoids	183-193	spen family transcriptional repressor	Homo sapiens	197-201
29373533-0	2018	Suppression of Fatty Acid and Triglyceride Synthesis by the Flavonoid Orientin through Decrease of C/EBPdelta Expression and Inhibition of PI3K/Akt-FOXO1 Signaling in Adipocytes.	Flavonoids	60-69	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	99-109
29373533-0	2018	Suppression of Fatty Acid and Triglyceride Synthesis by the Flavonoid Orientin through Decrease of C/EBPdelta Expression and Inhibition of PI3K/Akt-FOXO1 Signaling in Adipocytes.	Flavonoids	60-69	thymoma viral proto-oncogene 1	Mus musculus	144-147
29373533-0	2018	Suppression of Fatty Acid and Triglyceride Synthesis by the Flavonoid Orientin through Decrease of C/EBPdelta Expression and Inhibition of PI3K/Akt-FOXO1 Signaling in Adipocytes.	Flavonoids	60-69	forkhead box O1	Mus musculus	148-153
29373533-8	2018	These results indicate that a plant flavonoid orientin suppressed the expression of the Ppargamma gene through repression of C/ebpdelta expression and inhibition of the phosphoinositide 3-kinase /Akt-FOXO1 signaling in adipocytes.	Flavonoids	36-45	peroxisome proliferator activated receptor gamma	Mus musculus	88-97
29373533-8	2018	These results indicate that a plant flavonoid orientin suppressed the expression of the Ppargamma gene through repression of C/ebpdelta expression and inhibition of the phosphoinositide 3-kinase /Akt-FOXO1 signaling in adipocytes.	Flavonoids	36-45	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	125-135
29373533-8	2018	These results indicate that a plant flavonoid orientin suppressed the expression of the Ppargamma gene through repression of C/ebpdelta expression and inhibition of the phosphoinositide 3-kinase /Akt-FOXO1 signaling in adipocytes.	Flavonoids	36-45	thymoma viral proto-oncogene 1	Mus musculus	196-199
29373533-8	2018	These results indicate that a plant flavonoid orientin suppressed the expression of the Ppargamma gene through repression of C/ebpdelta expression and inhibition of the phosphoinositide 3-kinase /Akt-FOXO1 signaling in adipocytes.	Flavonoids	36-45	forkhead box O1	Mus musculus	200-205
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Flavonoids	52-62	catechol-O-methyltransferase	Homo sapiens	149-178
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Flavonoids	52-62	catechol-O-methyltransferase	Homo sapiens	180-184
29348256-4	2018	Flavonoids, for example, have effects on skeletal muscle, adipocytes, liver, and pancreas, and myocardial, renal, and immune cells, for instance, related to 5"-monophosphate-activated protein kinase phosphorylation, endothelial NO synthase activation, and suppression of NF-kappaB (nuclear factor-kappaB) and TLR4 (toll-like receptor 4).	Flavonoids	0-10	toll like receptor 4	Homo sapiens	309-313
29348256-4	2018	Flavonoids, for example, have effects on skeletal muscle, adipocytes, liver, and pancreas, and myocardial, renal, and immune cells, for instance, related to 5"-monophosphate-activated protein kinase phosphorylation, endothelial NO synthase activation, and suppression of NF-kappaB (nuclear factor-kappaB) and TLR4 (toll-like receptor 4).	Flavonoids	0-10	toll like receptor 4	Homo sapiens	315-335
29196136-6	2018	Then, kohonen and LDA were applied to develop QSAR models for ABCA1 up-regulators based flavonoids.	Flavonoids	88-98	ATP binding cassette subfamily A member 1	Homo sapiens	62-67
29196136-8	2018	The QSAR model prediction revealed 67 flavonoids in WDD were ABCA1 up-regulators.	Flavonoids	38-48	ATP binding cassette subfamily A member 1	Homo sapiens	61-66
29268246-8	2018	The flavonoids catechin and cyanidin were not inhibitors of MAO by HPLC-DAD but highly inhibited the oxidation of TMB (or Amplex Red) by peroxidase whereas quercetin and resveratrol were moderate inhibitors of MAO-A by HPLC-DAD, but inhibited the peroxidase assay in a higher level.	Flavonoids	4-14	monoamine oxidase A	Homo sapiens	210-215
29568754-7	2018	Quercetin and flavonoids significantly contributed to MAO-A inhibition.	Flavonoids	14-24	monoamine oxidase A	Homo sapiens	54-59
29507585-7	2018	In a word, the total flavonoids of the FK had an anti-inflammatory effect on the DNCB-induced ACD rat; this regulatory mechanism was highly possible based on the pERK1/2/TLR4-NF-kappaB pathway activation.	Flavonoids	21-31	toll-like receptor 4	Rattus norvegicus	170-174
29100755-3	2018	This study aimed to determine the beneficial effects and potential underlying mechanisms of total flavonoid extract from Dracoephalum moldavica L. (TFDM) for attenuating Alzheimer-related deficits induced by Abeta.	Flavonoids	98-107	amyloid beta (A4) precursor protein	Mus musculus	208-213
29268246-6	2018	The new method was applied to study the inhibition of human MAO-A and -B by bioactive compounds including beta-carboline alkaloids and flavonoids occurring in foods and plants.	Flavonoids	135-145	monoamine oxidase A	Homo sapiens	60-72
29444501-2	2018	Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro.	Flavonoids	33-42	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	105-109
29298656-8	2018	Notably, this encapsulated flavonoid supplementation; prevented emergence of neoplastic daughter clones from senescent mother phenotypes in pro-oxidant treated GC-1 spg and B/CMBA.Ov cells by selective abrogation of mitochondrial oxidative stress-induced aberrant epigenetic modifications.	Flavonoids	27-36	natriuretic peptide receptor 2	Mus musculus	160-174
29389596-0	2018	Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.	Flavonoids	0-9	PGP	Canis lupus familiaris	47-61
29032047-3	2018	According to former studies with bovine LPO selected flavonoids were tested in respect to their potential to reactivate the enzymatic activity in a more physiological, human salivary system.	Flavonoids	53-63	lactoperoxidase	Bos taurus	40-43
29032047-7	2018	Moreover selected flavonoids or an ethanolic extract of Tormentillae rhizoma were applied to test their regenerating effect on the LPO-derived -OSCN production.	Flavonoids	18-28	lactoperoxidase	Homo sapiens	131-134
29038004-3	2018	Flavonoids reduce Abeta production, inhibit neuroinflammation, increase cerebrovascular function, and improve cognitive performance.	Flavonoids	0-10	amyloid beta (A4) precursor protein	Mus musculus	18-23
30212825-0	2018	Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway.	Flavonoids	6-16	microRNA 21a	Mus musculus	84-90
30212825-0	2018	Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway.	Flavonoids	6-16	SMAD family member 7	Mus musculus	91-96
28682647-6	2018	Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-kappaB, AP-1, PPAR, Nrf2, and MAPKs.	Flavonoids	8-18	peroxisome proliferator activated receptor alpha	Homo sapiens	148-152
28682647-6	2018	Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-kappaB, AP-1, PPAR, Nrf2, and MAPKs.	Flavonoids	8-18	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
29175190-0	2018	Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study.	Flavonoids	49-59	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	14-45
29175190-2	2018	In the present work, the in vitro inhibitory activity of a panel of structurally related flavonoids, for recombinant human PTP1B was studied and the type of inhibition of the most active compounds further evaluated.	Flavonoids	89-99	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	123-128
29175190-3	2018	The majority of the studied flavonoids was tested in this work for the first time, including flavonoid C13, which was the most potent inhibitor.	Flavonoids	28-38	homeobox C13	Homo sapiens	103-106
29175190-3	2018	The majority of the studied flavonoids was tested in this work for the first time, including flavonoid C13, which was the most potent inhibitor.	Flavonoids	28-37	homeobox C13	Homo sapiens	103-106
29175190-5	2018	In conclusion, some of the tested flavonoids seem to be promising PTP1B inhibitors and potential effective agents in the management of T2DM, by increasing insulin sensitivity.	Flavonoids	34-44	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	66-71
29175190-5	2018	In conclusion, some of the tested flavonoids seem to be promising PTP1B inhibitors and potential effective agents in the management of T2DM, by increasing insulin sensitivity.	Flavonoids	34-44	insulin	Homo sapiens	155-162
30246635-6	2018	Using the recently identified flavonoid, nobiletin, as a PER2 enhancer completely abolished the deleterious effects of midazolam during myocardial IR-injury.	Flavonoids	30-39	period circadian clock 2	Mus musculus	57-61
29984664-2	2018	Of particular interest regarding cancer preventive properties of flavonoids is their interaction with cytochrome P450 enzymes (CYPs).	Flavonoids	65-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	102-117
29122665-0	2018	In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs.	Flavonoids	27-36	PGP	Canis lupus familiaris	64-78
29122665-2	2018	Herein, we aimed to explore dual combinations of the flavonoids baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin to reverse the interference of P-gp on the intracellular accumulation of antiepileptic drugs (AEDs).	Flavonoids	53-63	PGP	Canis lupus familiaris	172-176
29122665-8	2018	Thus, dual flavonoid combinations may be useful to overcome the P-gp-mediated efflux of AEDs and their metabolites, making their association to AED therapy a potentially valuable approach to circumvent pharmacoresistance in epilepsy.	Flavonoids	11-20	PGP	Canis lupus familiaris	64-68
29389596-4	2018	Herein, the strategy of flavonoid/AED combined therapy was exploited as a possible approach to overcome the P-gp-mediated pharmacoresistance.	Flavonoids	24-33	PGP	Canis lupus familiaris	108-112
29389596-8	2018	Furthermore, the most promising flavonoids as P-gp inhibitors promoted a significant increase on the intracellular accumulation of the AEDs (excluding lamotrigine) and their active metabolites in MDCK-MDR1 cells, evidencing to be important drug candidates to reverse the AED-resistance.	Flavonoids	32-42	PGP	Canis lupus familiaris	46-50
29389596-8	2018	Furthermore, the most promising flavonoids as P-gp inhibitors promoted a significant increase on the intracellular accumulation of the AEDs (excluding lamotrigine) and their active metabolites in MDCK-MDR1 cells, evidencing to be important drug candidates to reverse the AED-resistance.	Flavonoids	32-42	ATP binding cassette subfamily B member 1	Canis lupus familiaris	196-205
29491626-7	2018	SUMMARY: The wheat grass contains high amount of bioflavonoids, alkaloids, SOD etc which are responsible for anti oxidant activity.The Bauhinia purpurea contains glycosides, flavonoids and also plays a major role in DPPH activity which is responsible for anti oxidant activity.The wheat grass (10 mg/kg) and bauhinia (200 mg/kg) significantly(P &lt; 0.0001) reduced the percentage of infract size when compared to Ischemia reperfusion control group.The wheat grass (10 mg/kg) and bauhinia (200 mg/kg) significantly (P &lt;0.0001) reduced the lipid peroxidation (MDA) and increased SOD and Catalase.	Flavonoids	49-62	SOD	Triticum aestivum	581-584
29755555-9	2018	EE and its rich-flavonoids fractions inhibited secondary inflammatory reactions, diminished the specific histopathological alterations in the joint capsule and reduced the serum concentrations of the pro-inflammatory cytokines IL-6, TNF-alpha, and GM-CSF in arthritic rats.	Flavonoids	16-26	interleukin 6	Rattus norvegicus	227-231
29755555-9	2018	EE and its rich-flavonoids fractions inhibited secondary inflammatory reactions, diminished the specific histopathological alterations in the joint capsule and reduced the serum concentrations of the pro-inflammatory cytokines IL-6, TNF-alpha, and GM-CSF in arthritic rats.	Flavonoids	16-26	tumor necrosis factor	Rattus norvegicus	233-242
29755555-9	2018	EE and its rich-flavonoids fractions inhibited secondary inflammatory reactions, diminished the specific histopathological alterations in the joint capsule and reduced the serum concentrations of the pro-inflammatory cytokines IL-6, TNF-alpha, and GM-CSF in arthritic rats.	Flavonoids	16-26	colony stimulating factor 2	Rattus norvegicus	248-254
28977348-7	2018	In cytotoxicity test these two flavonoids exhibited moderate inhibitory activities against HepG2 cells with the IC50 values of 12.54 +- 1.37 and 38.63 +- 4.05 muM, respectively.	Flavonoids	31-41	latexin	Homo sapiens	159-162
29317180-1	2018	To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats.	Flavonoids	114-124	carbonic anhydrase 1	Rattus norvegicus	189-192
29375715-0	2018	Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway.	Flavonoids	8-17	AKT serine/threonine kinase 1	Homo sapiens	138-141
29375715-0	2018	Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway.	Flavonoids	8-17	mechanistic target of rapamycin kinase	Homo sapiens	142-146
29491634-9	2018	Experimentally, butanolic tuber fraction confirmed promising antioxidant potential (ABTS: IC50: 271.67 mug/ml; DPPH: IC50: 723.41 mug/ml) with a noteworthy amount of FRAP (195.96 mug/mg), total phenolic content (0.087 mug/mg), and total flavonoid content (7.5 mug/mg) while chloroform fraction (leaves) showed considerable reduction in the cell viability of MCF-7 cell line.	Flavonoids	237-246	mechanistic target of rapamycin kinase	Homo sapiens	166-170
28902451-6	2018	Enzyme activity of UGT76E11 to glucosylate quercetin and other flavonoids was confirmed.	Flavonoids	63-73	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	19-27
28678657-2	2018	Computational modeling was advanced to scrutinize some bioflavonoids which play roles in herb-drug interactions as P-gp inhibitors utilizing molecular docking and pharmacophore analyses.	Flavonoids	55-68	phosphoglycolate phosphatase	Mus musculus	115-119
28902451-7	2018	Ectopic expression of UGT76E11 resulted in significantly increased flavonoid content in transgenic plants compared to wild type, suggesting a contribution of UGT76E11 to modulation of flavonoid metabolism.	Flavonoids	67-76	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	22-30
28902451-7	2018	Ectopic expression of UGT76E11 resulted in significantly increased flavonoid content in transgenic plants compared to wild type, suggesting a contribution of UGT76E11 to modulation of flavonoid metabolism.	Flavonoids	184-193	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	22-30
28902451-7	2018	Ectopic expression of UGT76E11 resulted in significantly increased flavonoid content in transgenic plants compared to wild type, suggesting a contribution of UGT76E11 to modulation of flavonoid metabolism.	Flavonoids	184-193	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	158-166
28902451-10	2018	Based on these results, we suggest that the glycosyltransferase UGT76E11 plays an important role in modulating flavonoid metabolism and enhancing plant adaptation to environmental stresses.	Flavonoids	111-120	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	64-72
28902451-11	2018	Our findings might allow use of glycosyltransferase UGT76E11 in crop improvement, towards both enhanced stress tolerance and increased flavonoid accumulation.	Flavonoids	135-144	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	52-60
29100712-4	2018	This study shows that quercetin, a naturally occurring flavonoid, inhibits hemolytic activity in a dose-dependent manner and reduces alpha toxin secretion in culture supernatants of methicillin-sensitive and methicillin-resistant S.aureus.	Flavonoids	55-64	AT695_RS01930	Staphylococcus aureus	139-144
29473535-6	2018	RESULT: The effect of TQ on NF-kappabeta is the hepatoprotective effect of this flavonoid.	Flavonoids	80-89	nuclear factor kappa B subunit 1	Homo sapiens	28-40
29552854-0	2018	[Qualitative characterization of flavonoids in Scutellariae Radix by using PREC-IDA-EPI].	Flavonoids	33-43	tissue factor pathway inhibitor	Homo sapiens	84-87
29552854-4	2018	Based on the review of flavonoids that had been extracted from Scutellariae Radix, a method with PREC-IDA-EPI technique was developed and applied to Scutellariae Radix by using UPLC-MS/MS.	Flavonoids	23-33	tissue factor pathway inhibitor	Homo sapiens	106-109
29089261-1	2017	A novel series of flavonoid based compounds were designed, synthesized and biologically evaluated for Acetylcholinesterase (AChE) inhibitory activity integrated with advanced glycation end products (AGEs) inhibitory and antioxidant potential.	Flavonoids	18-27	acetylcholinesterase	Mus musculus	102-122
29326940-0	2017	Flavonoids from Engineered Tomatoes Inhibit Gut Barrier Pro-inflammatory Cytokines and Chemokines, via SAPK/JNK and p38 MAPK Pathways.	Flavonoids	0-10	mitogen-activated protein kinase 14	Mus musculus	116-119
29261137-0	2017	TRANSPARENT TESTA GLABRA 1-Dependent Regulation of Flavonoid Biosynthesis.	Flavonoids	51-60	myb domain protein 0	Arabidopsis thaliana	18-26
29261137-2	2017	Arabidopsis thaliana TRANSPARENT TESTA GLABRA 1 (AtTTG1) is an essential regulator of late structural genes in flavonoid biosynthesis.	Flavonoids	111-120	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	21-47
29261137-2	2017	Arabidopsis thaliana TRANSPARENT TESTA GLABRA 1 (AtTTG1) is an essential regulator of late structural genes in flavonoid biosynthesis.	Flavonoids	111-120	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	49-55
29089261-1	2017	A novel series of flavonoid based compounds were designed, synthesized and biologically evaluated for Acetylcholinesterase (AChE) inhibitory activity integrated with advanced glycation end products (AGEs) inhibitory and antioxidant potential.	Flavonoids	18-27	acetylcholinesterase	Mus musculus	124-128
28912067-1	2017	Sulfotransferase 1E1 (SULT1E1, also known as estrogen sulfotransferase) plays an important role in metabolism and detoxification of many endogenous and exogenous compounds (e.g., estrogens and flavonoids).	Flavonoids	193-203	sulfotransferase family 1E member 1	Homo sapiens	0-20
29312518-0	2017	Morin, a plant derived flavonoid, modulates the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha mediated by AMPK pathway in hepatic stellate cells.	Flavonoids	23-32	PPARG coactivator 1 alpha	Homo sapiens	62-129
29312518-0	2017	Morin, a plant derived flavonoid, modulates the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha mediated by AMPK pathway in hepatic stellate cells.	Flavonoids	23-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	142-146
28370226-0	2017	Total flavonoids of Epimedium reduce ageing-related oxidative DNA damage in testis of rats via p53-dependent pathway.	Flavonoids	6-16	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	95-98
29232935-0	2017	Extraction Optimization of Flavonoids from Hypericum formosanum and Matrix Metalloproteinase-1 Inhibitory Activity.	Flavonoids	27-37	matrix metallopeptidase 1	Homo sapiens	68-94
28912067-1	2017	Sulfotransferase 1E1 (SULT1E1, also known as estrogen sulfotransferase) plays an important role in metabolism and detoxification of many endogenous and exogenous compounds (e.g., estrogens and flavonoids).	Flavonoids	193-203	sulfotransferase family 1E member 1	Homo sapiens	22-29
28912067-1	2017	Sulfotransferase 1E1 (SULT1E1, also known as estrogen sulfotransferase) plays an important role in metabolism and detoxification of many endogenous and exogenous compounds (e.g., estrogens and flavonoids).	Flavonoids	193-203	sulfotransferase family 1E member 1	Homo sapiens	45-70
28970059-0	2017	Structural requirements of flavonoids to induce heme oxygenase-1 expression.	Flavonoids	27-37	heme oxygenase 1	Mus musculus	48-64
28882412-0	2017	A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS.	Flavonoids	2-11	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	27-31
28882412-0	2017	A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS.	Flavonoids	2-11	brain derived neurotrophic factor	Mus musculus	45-49
28882412-0	2017	A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS.	Flavonoids	2-11	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	124-130
29162466-1	2017	Myricetin is a flavonoid that inhibits human proton-coupled folate transporter (hPCFT) in a transient manner, in which inhibition is manifested in its presence, and also in a sustained manner, in which inhibition induced in its presence persists after its removal.	Flavonoids	15-24	solute carrier family 46 member 1	Homo sapiens	45-78
29162466-1	2017	Myricetin is a flavonoid that inhibits human proton-coupled folate transporter (hPCFT) in a transient manner, in which inhibition is manifested in its presence, and also in a sustained manner, in which inhibition induced in its presence persists after its removal.	Flavonoids	15-24	solute carrier family 46 member 1	Homo sapiens	80-85
28970059-3	2017	The present study investigated the structural requirements of flavonoids to induce Hmox1 in human aortic endothelial cells (HAEC).	Flavonoids	62-72	heme oxygenase 1	Homo sapiens	83-88
28970059-5	2017	Active but not inactive flavonoids had a low oxidation potential and prevented ascorbate autoxidation, suggesting that Hmox1 inducers readily undergo oxidation and that oxidized, rather than reduced, flavonoids may be the biological inducer of Hmox1.	Flavonoids	24-34	heme oxygenase 1	Mus musculus	244-249
28970059-5	2017	Active but not inactive flavonoids had a low oxidation potential and prevented ascorbate autoxidation, suggesting that Hmox1 inducers readily undergo oxidation and that oxidized, rather than reduced, flavonoids may be the biological inducer of Hmox1.	Flavonoids	200-210	heme oxygenase 1	Mus musculus	244-249
28970059-2	2017	We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role.	Flavonoids	32-41	apolipoprotein E	Mus musculus	149-165
28970059-2	2017	We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role.	Flavonoids	32-41	heme oxygenase 1	Mus musculus	204-220
28970059-2	2017	We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role.	Flavonoids	32-41	heme oxygenase 1	Mus musculus	222-227
28872689-5	2017	METHODS: Two flavonoids, luteolin and quercetin, were evaluated as potential inhibitors of eight human CYP isoforms, of six UDP-glucuronosyltransferase (UGT) isoforms and of APAP glucuronidation and sulfation.	Flavonoids	13-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
28856944-4	2017	Flavonoids were most effective in inhibition against CYP2A6 and CYP2A13, followed by thiophenes, and hirsutinolides.	Flavonoids	0-10	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	64-71
28933564-0	2017	alpha-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study.	Flavonoids	32-42	sucrase-isomaltase	Homo sapiens	0-17
28933564-2	2017	As flavonoids are promising modulators of this enzyme"s activity, a panel of 44 flavonoids, organised in five groups, was screened for their inhibitory activity of alpha-glucosidase, based on in vitro structure-activity relationship studies.	Flavonoids	3-13	sucrase-isomaltase	Homo sapiens	164-181
28933564-2	2017	As flavonoids are promising modulators of this enzyme"s activity, a panel of 44 flavonoids, organised in five groups, was screened for their inhibitory activity of alpha-glucosidase, based on in vitro structure-activity relationship studies.	Flavonoids	80-90	sucrase-isomaltase	Homo sapiens	164-181
28933564-4	2017	A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC50 much lower than the one found for the most widely prescribed alpha-glucosidase inhibitor, acarbose.	Flavonoids	2-11	sucrase-isomaltase	Homo sapiens	195-212
28872689-5	2017	METHODS: Two flavonoids, luteolin and quercetin, were evaluated as potential inhibitors of eight human CYP isoforms, of six UDP-glucuronosyltransferase (UGT) isoforms and of APAP glucuronidation and sulfation.	Flavonoids	13-23	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	124-151
28872689-5	2017	METHODS: Two flavonoids, luteolin and quercetin, were evaluated as potential inhibitors of eight human CYP isoforms, of six UDP-glucuronosyltransferase (UGT) isoforms and of APAP glucuronidation and sulfation.	Flavonoids	13-23	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	153-156
27937032-2	2017	Naringin (Nar) is a bioflavonoid that has antioxidant activity and suppresses MMP-9 expression.	Flavonoids	20-32	matrix metallopeptidase 9	Rattus norvegicus	78-83
27650551-7	2017	Licorice extract, 3 triterpenes and 13 flavonoids exhibit evident anti-inflammatory properties mainly by decreasing TNF, MMPs, PGE2 and free radicals, which also explained its traditional applications in stimulating digestive system functions, eliminating phlegm, relieving coughing, nourishing qi and alleviating pain in TCM.	Flavonoids	39-49	tumor necrosis factor	Homo sapiens	116-119
29170442-5	2017	We identified the flavonoid luteolin as an inhibitor of the PKR/PACT interaction at the level of their DRBDs using high-throughput screening of chemical libraries by homogeneous time-resolved fluorescence.	Flavonoids	18-27	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	60-63
27659804-0	2017	Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl4-induced changes in the genetic materials in male rats.	Flavonoids	0-9	C-C motif chemokine ligand 4	Rattus norvegicus	76-80
27925497-5	2017	Several flavonoids can inhibit GSK3beta and the purpose of this study was to search for the compounds in Diplotaxis harra which are able to modulate GSK3beta.	Flavonoids	8-18	glycogen synthase kinase 3 beta	Homo sapiens	31-39
27925497-5	2017	Several flavonoids can inhibit GSK3beta and the purpose of this study was to search for the compounds in Diplotaxis harra which are able to modulate GSK3beta.	Flavonoids	8-18	glycogen synthase kinase 3 beta	Homo sapiens	149-157
27925497-9	2017	RESULTS: The methanol extract from D. harra flowers and its flavonoid-enriched fraction inhibit GSK3beta in PAR2-stimulated IEC6 cells.	Flavonoids	60-69	glycogen synthase kinase 3 beta	Homo sapiens	96-104
27925497-10	2017	GSK3beta inhibition by the flavonoid-enriched D. harra fraction was dependent on PKC activation.	Flavonoids	27-36	glycogen synthase kinase 3 beta	Homo sapiens	0-8
27925497-13	2017	CONCLUSION: This work indicates that flavonoids from D. harra display cytotoxic activity against inflammatory and cancer intestinal cells which could depend on GSK3beta inhibition.	Flavonoids	37-47	glycogen synthase kinase 3 beta	Homo sapiens	160-168
29551926-6	2017	The total flavonoid in rabdosia rubescens can decrease the mortality of mice, decrease serum NSE level, increase the content of NO and the activity of NOS in the brain tissue of mice, and improve the pathological damage of cortex and hippocampus of mice.	Flavonoids	10-19	enolase 2, gamma neuronal	Mus musculus	93-96
29551926-7	2017	Conclusion: The total flavonoid in rabdosia rubescens can stimulate an endogenous protective mechanism by inducing the release of low levels of cytokines NO and NOS, which reduces the release of serum NSE, relieves the brain tissue ischemia-reperfusion injury, and further improves the protection effect of ischemic preconditioning on brain injury.	Flavonoids	22-31	enolase 2, gamma neuronal	Mus musculus	201-204
29551938-8	2017	But compared with the ischemia-reperfusion group, the total flavonoid of ilex pubesceus can significantly or obviously increase the iNOS activity, IL-1beta content and TNF-alpha content in the brain tissue of the rats.	Flavonoids	60-69	nitric oxide synthase 2	Rattus norvegicus	132-136
29551938-8	2017	But compared with the ischemia-reperfusion group, the total flavonoid of ilex pubesceus can significantly or obviously increase the iNOS activity, IL-1beta content and TNF-alpha content in the brain tissue of the rats.	Flavonoids	60-69	interleukin 1 beta	Rattus norvegicus	147-155
29551938-8	2017	But compared with the ischemia-reperfusion group, the total flavonoid of ilex pubesceus can significantly or obviously increase the iNOS activity, IL-1beta content and TNF-alpha content in the brain tissue of the rats.	Flavonoids	60-69	tumor necrosis factor	Rattus norvegicus	168-177
29551949-3	2017	The measured total polyphenol and flavonoid content of AHL was 184.24 +- 5.01 mg GAE/g and 102.53 +- 0.98 mg NAR/g.	Flavonoids	34-43	cadherin 23 (otocadherin)	Mus musculus	55-58
29186068-6	2017	Most flavonoids exhibited a ratio of 0.8-1.5 for Papp A to B/Papp B to A, suggesting passive diffusion pathways.	Flavonoids	5-15	pappalysin 1	Homo sapiens	49-55
28140748-1	2017	CONTEXT: The effects of icariin, a chief constituent of flavonoids from Epimedium brevicornum Maxim (Berberidaceae), on the levels of HIF-1alpha, HSP-60 and HSP-70 remain unknown.	Flavonoids	56-66	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	134-144
29170442-5	2017	We identified the flavonoid luteolin as an inhibitor of the PKR/PACT interaction at the level of their DRBDs using high-throughput screening of chemical libraries by homogeneous time-resolved fluorescence.	Flavonoids	18-27	RB binding protein 6, ubiquitin ligase	Homo sapiens	64-68
28753501-2	2017	METHODS: Inactivation effects of citrus flavonoids (Hst, Hsd, Nge) at different concentrations on soluble collagenase were measured using a fluorometric assay.	Flavonoids	40-50	fibroblast growth factor 4	Homo sapiens	52-55
29023372-0	2017	PARP Inhibition by Flavonoids Induced Selective Cell Killing to BRCA2-Deficient Cells.	Flavonoids	19-29	poly [ADP-ribose] polymerase 1	Cricetulus griseus	0-4
28663152-6	2017	Circular Dichroism (CD) spectra have shown distinct loss in alpha-helical structure of the catalase on interaction with the flavonoids.	Flavonoids	124-134	catalase	Homo sapiens	91-99
28663152-7	2017	All flavonoids inhibited the catalase activity by uncompetitive mechanism.	Flavonoids	4-14	catalase	Homo sapiens	29-37
28663152-9	2017	Inhibition of catalase will directly results in increased production of Reactive Oxygen Species (ROS) and pro-oxidant property of flavonoids.	Flavonoids	130-140	catalase	Homo sapiens	14-22
29083228-7	2017	These results clearly designate the functional dietary flavonoid rutin as a potential lead for the prevention and control of c-Met-dependent breast malignancies.	Flavonoids	55-64	met proto-oncogene	Mus musculus	125-130
29070784-5	2017	The effect of kaempferol, a flavonoid enhancing TRAIL-induced apoptosis in ovarian cancer cells, was investigated in this study.	Flavonoids	28-37	TNF superfamily member 10	Homo sapiens	48-53
28663152-0	2017	Catalase inhibition an anti cancer property of flavonoids: A kinetic and structural evaluation.	Flavonoids	47-57	catalase	Homo sapiens	0-8
28663152-2	2017	Flavonoids have inhibitory effects on enzymes and catalase is one among them.	Flavonoids	0-10	catalase	Homo sapiens	50-58
28663152-5	2017	Inhibition of pure and cellular catalase from K562 cells by flavonoids was similar and exhibited the following efficacy; Myrecetin&gt;Quercetin&gt;Kaempferol and Quercetin&gt;Luteolin&gt;Apigenin demonstrating structure activity relationship.	Flavonoids	60-70	catalase	Homo sapiens	32-40
28513070-2	2017	Thus, the aim of presented study was to analyse human serum albumin-binding displacement interaction between two ligands, hypoglycaemic drug gliclazide and widely distributed plant flavonoid quercetin.	Flavonoids	181-190	albumin	Homo sapiens	54-67
28833790-1	2017	Natural standardized flavonoid extract from the bark of Pinus pinaster, Pycnogenol (Pyc), was recently found to decrease intensively the activity of sarcoplasmic reticulum Ca2+ -ATPase of rabbit skeletal muscle (SERCA1).	Flavonoids	21-30	sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus	212-218
29023372-0	2017	PARP Inhibition by Flavonoids Induced Selective Cell Killing to BRCA2-Deficient Cells.	Flavonoids	19-29	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	64-69
29023372-3	2017	We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells.	Flavonoids	28-38	poly [ADP-ribose] polymerase 1	Cricetulus griseus	158-162
29023372-3	2017	We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells.	Flavonoids	28-38	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	224-229
29023372-11	2017	These results suggest that flavonoids with the PARP inhibitory effect can cause synthetic lethality to BRCA2-deficient cells when other pathways are not the primary cause of death.	Flavonoids	27-37	poly [ADP-ribose] polymerase 1	Cricetulus griseus	47-51
28664315-1	2017	OBJECTIVE: To find an inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that rapidly metabolises Prostaglandin E2 (PGE2) as a mediator of wound healing, we examined seven flavonoids for this role.	Flavonoids	182-192	carbonyl reductase 1	Homo sapiens	35-72
28504248-0	2017	The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex.	Flavonoids	4-13	TNF superfamily member 10	Homo sapiens	14-20
28504248-0	2017	The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex.	Flavonoids	4-13	activator of HSP90 ATPase activity 1	Homo sapiens	121-125
28504248-0	2017	The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex.	Flavonoids	4-13	heat shock protein 90 alpha family class A member 1	Homo sapiens	126-131
29051765-7	2017	Three transcription factor (TF) genes, including one bHLH gene and two MYB-related genes that are located within the previous seed coat color quantitative trait locus (QTL) region on chromosome A09, also showed similar developmental expression patterns to the key PA biosynthetic genes and they might thus potentially involved participate in flavonoid biosynthesis regulation.	Flavonoids	342-351	transcription factor ABORTED MICROSPORES-like	Brassica napus	53-57
28664315-1	2017	OBJECTIVE: To find an inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that rapidly metabolises Prostaglandin E2 (PGE2) as a mediator of wound healing, we examined seven flavonoids for this role.	Flavonoids	182-192	carbonyl reductase 1	Homo sapiens	74-81
28583009-0	2017	Inhibition of alpha-Synuclein contributes to the ameliorative effects of dietary flavonoids luteolin on arsenite-induced apoptotic cell death in the dopaminergic PC12 cells.	Flavonoids	81-91	synuclein alpha	Rattus norvegicus	14-29
28322972-4	2017	Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3",5"-tetramethoxystilbene.	Flavonoids	13-23	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	80-86
29200726-0	2017	Influence of Flavonoids on Mechanism of Modulation of Insulin Secretion.	Flavonoids	13-23	insulin	Homo sapiens	54-61
29200726-3	2017	In particular, flavonoids are potential candidates to act as insulin secretagogue.	Flavonoids	15-25	insulin	Homo sapiens	61-68
29200726-4	2017	Objective: To study the influence of flavonoid on overall modulation mechanisms of insulin secretion.	Flavonoids	37-46	insulin	Homo sapiens	83-90
29200726-6	2017	Results: Twelve articles were included and represent the basis of discussion on mechanisms of insulin secretion of flavonoids.	Flavonoids	115-125	insulin	Homo sapiens	94-101
29200726-8	2017	Conclusion: According to the literature, the majority of flavonoid subclasses can modulate insulin secretion through several pathways, in an indication that corresponding molecule is a potential candidate for active materials to be applied in the treatment of diabetes.	Flavonoids	57-66	insulin	Homo sapiens	91-98
29200726-9	2017	SUMMARY: The action of natural products on insulin secretion represents an important investigation topic due to their importance in the diabetes controlIn addition to their typical antioxidant properties, flavonoids contribute to the insulin secretionThe modulation of insulin secretion is induced by flavonoids according to different mechanisms.	Flavonoids	205-215	insulin	Homo sapiens	43-50
29200726-9	2017	SUMMARY: The action of natural products on insulin secretion represents an important investigation topic due to their importance in the diabetes controlIn addition to their typical antioxidant properties, flavonoids contribute to the insulin secretionThe modulation of insulin secretion is induced by flavonoids according to different mechanisms.	Flavonoids	205-215	insulin	Homo sapiens	234-241
29200726-9	2017	SUMMARY: The action of natural products on insulin secretion represents an important investigation topic due to their importance in the diabetes controlIn addition to their typical antioxidant properties, flavonoids contribute to the insulin secretionThe modulation of insulin secretion is induced by flavonoids according to different mechanisms.	Flavonoids	205-215	insulin	Homo sapiens	234-241
29200726-9	2017	SUMMARY: The action of natural products on insulin secretion represents an important investigation topic due to their importance in the diabetes controlIn addition to their typical antioxidant properties, flavonoids contribute to the insulin secretionThe modulation of insulin secretion is induced by flavonoids according to different mechanisms.	Flavonoids	301-311	insulin	Homo sapiens	43-50
28873682-1	2017	Quercetin, a flavonoid compound, was found to inhibit both monophenolase and diphenolase activities of tyrosinase, and its inhibition against diphenolase activity was in a reversible and competitive manner with an IC50 value of (3.08+-0.74)x10-5molL-1.	Flavonoids	13-22	tyrosinase	Homo sapiens	103-113
28668616-5	2017	Such decline may be delayed by increasing Star and/or Cyp11a1 gene expressions using supplementation with flavonoids, a group of the polyphenolic compounds widely distributed in fruits and vegetables.	Flavonoids	106-116	steroidogenic acute regulatory protein	Mus musculus	42-46
28668616-5	2017	Such decline may be delayed by increasing Star and/or Cyp11a1 gene expressions using supplementation with flavonoids, a group of the polyphenolic compounds widely distributed in fruits and vegetables.	Flavonoids	106-116	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	54-61
28875706-1	2017	The inhibition of porcine pancreatic alpha-amylase and mammalian alpha-glucosidase by 16 individual flavonoids was determined.	Flavonoids	100-110	amylase alpha 2A	Homo sapiens	26-50
28875706-1	2017	The inhibition of porcine pancreatic alpha-amylase and mammalian alpha-glucosidase by 16 individual flavonoids was determined.	Flavonoids	100-110	sucrase-isomaltase	Homo sapiens	65-82
28875706-0	2017	Dietary Flavonoids and Acarbose Synergistically Inhibit alpha-Glucosidase and Lower Postprandial Blood Glucose.	Flavonoids	8-18	sucrase-isomaltase	Homo sapiens	56-73
28894166-0	2017	Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa.	Flavonoids	0-9	rhodopsin	Homo sapiens	50-59
28966623-9	2017	The cysts and juveniles in soil were reduced by 89.8 and 92.7%, the juveniles and females in roots were reduced by 88.3 and 91.3%, whereas the activity of chitinase and beta-1, 3-glucanase, total flavonoids and lignin contents in wheat roots were increased significantly at different stage after inoculation with the eggs and TL6 conidia in comparison to the control.	Flavonoids	196-206	basic endochitinase A	Triticum aestivum	155-164
28735729-13	2017	Moreover, Western blotting analysis demonstrated that protein expressions of Nrf-2 and HO-1 were also up-regulated by flavonoids treatment.	Flavonoids	118-128	NFE2 like bZIP transcription factor 2	Homo sapiens	77-82
28735729-13	2017	Moreover, Western blotting analysis demonstrated that protein expressions of Nrf-2 and HO-1 were also up-regulated by flavonoids treatment.	Flavonoids	118-128	heme oxygenase 1	Homo sapiens	87-91
28735729-14	2017	CONCLUSIONS: These results clearly demonstrate that the MeOH extracts and flavonoids from Korean milk thistle protected HepG2 cells against oxidative damage triggered by t-BHP principally by modulating ROS generation and restoring depleted GSH levels in addition to the increased Nrf-2/HO-1 signaling cascade.	Flavonoids	74-84	NFE2 like bZIP transcription factor 2	Homo sapiens	280-285
28735729-14	2017	CONCLUSIONS: These results clearly demonstrate that the MeOH extracts and flavonoids from Korean milk thistle protected HepG2 cells against oxidative damage triggered by t-BHP principally by modulating ROS generation and restoring depleted GSH levels in addition to the increased Nrf-2/HO-1 signaling cascade.	Flavonoids	74-84	heme oxygenase 1	Homo sapiens	286-290
28959020-0	2017	Synergetic effect of the Onion CHI gene on the PAP1 regulatory gene for enhancing the flavonoid profile of tomato skin.	Flavonoids	86-95	production of anthocyanin pigment 1	Arabidopsis thaliana	47-51
28959020-3	2017	The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoid flux and anthocyanin content.	Flavonoids	112-121	production of anthocyanin pigment 1	Arabidopsis thaliana	20-24
28959020-3	2017	The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoid flux and anthocyanin content.	Flavonoids	112-121	production of anthocyanin pigment 1	Arabidopsis thaliana	26-61
28894166-4	2017	We have analyzed the effect of the flavonoid quercetin on the conformation, stability and function of the G protein-coupled receptor rhodopsin, and the G90V mutant associated with the retinal degenerative disease retinitis pigmentosa.	Flavonoids	35-44	rhodopsin	Homo sapiens	133-142
28513167-9	2017	In summary, these results suggest that dietary aglycon flavonoids may significantly alter the pharmacokinetics and pharmacodynamics of bumetanide and other MCT6-specific substrates, and may represent potential substrates for MCT6.	Flavonoids	55-65	solute carrier family 16 member 5	Homo sapiens	156-160
28513167-9	2017	In summary, these results suggest that dietary aglycon flavonoids may significantly alter the pharmacokinetics and pharmacodynamics of bumetanide and other MCT6-specific substrates, and may represent potential substrates for MCT6.	Flavonoids	55-65	solute carrier family 16 member 5	Homo sapiens	225-229
28513167-0	2017	Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6.	Flavonoids	54-63	solute carrier family 16 member 5	Homo sapiens	78-107
28579594-8	2017	Overall, sulfuretin is a natural flavonoid having potent anti-adipogenic activity through the suppression of major adipogenic factors C/EBPalpha, C/EBPbeta and PPARgamma, which initiate adipogenesis.	Flavonoids	33-42	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	134-144
28513167-2	2017	To date, the impact of commonly ingested dietary compounds on MCT6 function has not been investigated, and therefore, the objective of this study was to evaluate a variety of flavonoids for their potential MCT6-specific interactions.	Flavonoids	175-185	solute carrier family 16 member 5	Homo sapiens	206-210
28513167-4	2017	The uptake of bumetanide in human MCT6 gene-transfected Xenopus laevis oocytes was significantly decreased in the presence of a variety of flavonoids (e.g., quercetin, luteolin, phloretin, and morin), but was not significantly affected by flavonoid glycosides (e.g., naringin, rutin, phlorizin).	Flavonoids	139-149	solute carrier family 16 member 5	Homo sapiens	34-38
28869563-9	2017	The representative putative targets of the flavonoids are inflammation-related proteins (TNF, NF-kappaB, F2, PTGS2, and PTGS2) and pruritus-related proteins (NR3C1 and IL2).	Flavonoids	43-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114
28869563-9	2017	The representative putative targets of the flavonoids are inflammation-related proteins (TNF, NF-kappaB, F2, PTGS2, and PTGS2) and pruritus-related proteins (NR3C1 and IL2).	Flavonoids	43-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125
28869563-9	2017	The representative putative targets of the flavonoids are inflammation-related proteins (TNF, NF-kappaB, F2, PTGS2, and PTGS2) and pruritus-related proteins (NR3C1 and IL2).	Flavonoids	43-53	nuclear receptor subfamily 3 group C member 1	Homo sapiens	158-163
28869563-9	2017	The representative putative targets of the flavonoids are inflammation-related proteins (TNF, NF-kappaB, F2, PTGS2, and PTGS2) and pruritus-related proteins (NR3C1 and IL2).	Flavonoids	43-53	interleukin 2	Homo sapiens	168-171
28892039-6	2017	Pretreatment of cells with flavonoid metabolites prior to high glucose challenge preserved insulin stimulated increases in NO production, p-AktSer473: Akt and p-eNOSSer1177: eNOS.	Flavonoids	27-36	AKT serine/threonine kinase 1	Homo sapiens	140-143
28579594-8	2017	Overall, sulfuretin is a natural flavonoid having potent anti-adipogenic activity through the suppression of major adipogenic factors C/EBPalpha, C/EBPbeta and PPARgamma, which initiate adipogenesis.	Flavonoids	33-42	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	146-155
28579594-8	2017	Overall, sulfuretin is a natural flavonoid having potent anti-adipogenic activity through the suppression of major adipogenic factors C/EBPalpha, C/EBPbeta and PPARgamma, which initiate adipogenesis.	Flavonoids	33-42	peroxisome proliferator activated receptor gamma	Mus musculus	160-169
28962214-6	2017	Following treatment with genistein, which is a flavonoid previously demonstrated to decrease airway inflammation in asthma, the allergic airway inflammation and airway hyper-responsiveness were attenuated and the Runx3 protein tended to augment in the nucleus.	Flavonoids	47-56	runt related transcription factor 3	Mus musculus	213-218
28641164-6	2017	Phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) pathways are both affected by Flavonoids.	Flavonoids	115-125	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	0-29
28641164-6	2017	Phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) pathways are both affected by Flavonoids.	Flavonoids	115-125	AKT serine/threonine kinase 1	Homo sapiens	37-40
28089688-0	2017	Functional Identification of Plasma Membrane Monoamine Transporter (PMAT/SLC29A4) as an Atenolol Transporter Sensitive to Flavonoids Contained in Apple Juice.	Flavonoids	122-132	solute carrier family 29 member 4	Canis lupus familiaris	73-80
28407912-8	2017	The bioactivity assays showed that isolated malonylated flavonoids inhibit the production of reactive oxygen species (IC50 in the range 22.4-40.6muM) and myeloperoxidase release (IC50 in the range 22.2-32.2muM) from stimulated human neutrophils.	Flavonoids	56-66	latexin	Homo sapiens	145-148
28480538-0	2017	Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by beta-glucuronidase in macrophages.	Flavonoids	30-39	glucuronidase, beta	Mus musculus	99-117
28480538-13	2017	CONCLUSIONS: This study suggests a molecular mechanism by which oral flavonoids are carried as glucuronides and activated to aglycones by beta-glucuronidase in tissue macrophages, and contributes to the pharmacological study of glucuronides.	Flavonoids	69-79	glucuronidase, beta	Mus musculus	138-156
28251647-7	2017	The improvement of the free and total phenolic and flavonoid contents by the germination process led to a significant enhancement of the antioxidant activities (evaluated by the ABTS, FRAP and ORAC assays).	Flavonoids	51-60	mechanistic target of rapamycin kinase	Homo sapiens	184-188
28445001-0	2017	Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes.	Flavonoids	30-40	carbonic anhydrase 1	Homo sapiens	44-71
28445001-4	2017	Both hCA isoenzymes were inhibited by flavonoids, with IC50 and Ki values in the range of 2.34 nM to 346.5 muM and 51.01-99.55 muM for hCA I and 86.60-750.00 muM for hCA II, respectively.	Flavonoids	38-48	carbonic anhydrase 1	Homo sapiens	135-140
28445001-4	2017	Both hCA isoenzymes were inhibited by flavonoids, with IC50 and Ki values in the range of 2.34 nM to 346.5 muM and 51.01-99.55 muM for hCA I and 86.60-750.00 muM for hCA II, respectively.	Flavonoids	38-48	carbonic anhydrase 2	Homo sapiens	166-172
28445001-5	2017	These results showed that flavonoids especially malvin and oenin effectively inhibited hCA I and II isoenzymes.	Flavonoids	26-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	87-99
28927111-7	2017	The results of the present study demonstrated that the flavonoid luteolin reduced the migration of glioblastoma cells by altering p-IGF-1R/PI3K/AKT/mTOR activation, and may have potential applications for chemoprevention in a clinical setting.	Flavonoids	55-64	insulin like growth factor 1 receptor	Homo sapiens	132-138
28370954-0	2017	Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice.	Flavonoids	7-16	WD and tetratricopeptide repeats 1	Mus musculus	66-73
28589248-4	2017	Quercetin, a plant pigment (flavonoid), is an antioxidant and HO-1 inducer.	Flavonoids	28-37	heme oxygenase 1	Rattus norvegicus	62-66
28927111-7	2017	The results of the present study demonstrated that the flavonoid luteolin reduced the migration of glioblastoma cells by altering p-IGF-1R/PI3K/AKT/mTOR activation, and may have potential applications for chemoprevention in a clinical setting.	Flavonoids	55-64	AKT serine/threonine kinase 1	Homo sapiens	144-147
28927111-7	2017	The results of the present study demonstrated that the flavonoid luteolin reduced the migration of glioblastoma cells by altering p-IGF-1R/PI3K/AKT/mTOR activation, and may have potential applications for chemoprevention in a clinical setting.	Flavonoids	55-64	mechanistic target of rapamycin kinase	Homo sapiens	148-152
28602979-0	2017	Inhibition of CYP4A by a novel flavonoid FLA-16 prolongs survival and normalizes tumor vasculature in glioma.	Flavonoids	31-40	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	14-19
28867797-0	2017	Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway.	Flavonoids	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	153-157
28602979-3	2017	Here, we tested whether a novel flavonoid (FLA-16) prolongs survival and normalizes tumor vasculature in glioma through CYP4A inhibition.	Flavonoids	32-41	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	120-125
28475422-4	2017	Using this system, we show here that the flavonoid derivative 4"-nitro-6-hydroxyflavone (NOHF) suppresses MTP promoter activity.	Flavonoids	41-50	microsomal triglyceride transfer protein	Homo sapiens	106-109
28693884-0	2017	The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.	Flavonoids	4-13	signaling lymphocytic activation molecule family member 1	Mus musculus	68-73
28693884-0	2017	The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.	Flavonoids	4-13	mannose receptor, C type 1	Mus musculus	74-79
28676257-3	2017	Baicalein (BAI), a flavonoid from Chinese herb, has been reported to bind covalently to alpha-syn to inhibit alpha-syn fibrillation and degrade its fibrils.	Flavonoids	19-28	synuclein, alpha	Mus musculus	88-97
28528971-1	2017	Chalcones, the biosynthetic precursors of flavonoids and isoflavonoids abundant in edible plants, possess a number of pharmacological properties, and there is growing evidence that chalcone derivatives inhibit TNF-alpha mediated insulin resistance.	Flavonoids	42-52	tumor necrosis factor	Mus musculus	210-219
28475422-0	2017	The flavonoid derivative 4"-nitro-6-hydroxyflavone suppresses the activity of HNF4alpha and stimulates the degradation of HNF4alpha protein through the activation of AMPK.	Flavonoids	4-13	hepatocyte nuclear factor 4 alpha	Homo sapiens	78-87
28475422-0	2017	The flavonoid derivative 4"-nitro-6-hydroxyflavone suppresses the activity of HNF4alpha and stimulates the degradation of HNF4alpha protein through the activation of AMPK.	Flavonoids	4-13	hepatocyte nuclear factor 4 alpha	Homo sapiens	122-131
28475422-0	2017	The flavonoid derivative 4"-nitro-6-hydroxyflavone suppresses the activity of HNF4alpha and stimulates the degradation of HNF4alpha protein through the activation of AMPK.	Flavonoids	4-13	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	166-170
28461245-0	2017	LFG-500, a novel synthetic flavonoid, suppresses epithelial-mesenchymal transition in human lung adenocarcinoma cells by inhibiting NLRP3 in inflammatory microenvironment.	Flavonoids	27-36	NLR family pyrin domain containing 3	Homo sapiens	132-137
28462502-2	2017	Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties.	Flavonoids	27-36	ATP binding cassette subfamily B member 1	Homo sapiens	64-78
28462502-2	2017	Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties.	Flavonoids	27-36	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
28462502-2	2017	Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties.	Flavonoids	27-36	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
28810652-0	2017	Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells.	Flavonoids	65-74	prostate stem cell antigen	Homo sapiens	14-40
28810652-2	2017	The present study evaluated the cytotoxicity of three flavonoids (genistein, luteolin and quercetin) towards DU145 prostate cancer cells, and investigated the effect of these flavonoids on PSCA expression.	Flavonoids	175-185	prostate stem cell antigen	Homo sapiens	189-193
28810652-5	2017	Notably, it was observed that expression of PSCA was inhibited at the mRNA (P&lt;0.05) and protein levels in DU145 cells following flavonoid treatment compared with the control.	Flavonoids	131-140	prostate stem cell antigen	Homo sapiens	44-48
28714504-0	2017	Tartary buckwheat flavonoids ameliorate high fructose-induced insulin resistance and oxidative stress associated with the insulin signaling and Nrf2/HO-1 pathways in mice.	Flavonoids	18-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
28810591-3	2017	Flavonoids have been demonstrated to activate aryl hydrocarbon receptor (Ahr), which is implicated in an array of cell signaling processes.	Flavonoids	0-10	aryl hydrocarbon receptor	Rattus norvegicus	46-71
28810591-3	2017	Flavonoids have been demonstrated to activate aryl hydrocarbon receptor (Ahr), which is implicated in an array of cell signaling processes.	Flavonoids	0-10	aryl hydrocarbon receptor	Rattus norvegicus	73-76
28602600-6	2017	Hence, our findings support the combination of flavonoid-type P-gp inhibitors and P-gp substrate antiepileptic drugs as a potential therapeutic strategy for the management of pharmacoresistant epilepsy.	Flavonoids	47-56	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	62-66
28703832-8	2017	The in vivo pre-treatment with 5 mg kg-1 of the flavonoid quercitrin reverts both the early hyporesponse of mesenteric arteries to noradrenaline and the up-regulation of iNOS, COX2, NOX1, TNFalpha and IL1beta in colitic rats.	Flavonoids	48-57	nitric oxide synthase 2	Rattus norvegicus	170-174
28703832-8	2017	The in vivo pre-treatment with 5 mg kg-1 of the flavonoid quercitrin reverts both the early hyporesponse of mesenteric arteries to noradrenaline and the up-regulation of iNOS, COX2, NOX1, TNFalpha and IL1beta in colitic rats.	Flavonoids	48-57	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	176-180
28703832-8	2017	The in vivo pre-treatment with 5 mg kg-1 of the flavonoid quercitrin reverts both the early hyporesponse of mesenteric arteries to noradrenaline and the up-regulation of iNOS, COX2, NOX1, TNFalpha and IL1beta in colitic rats.	Flavonoids	48-57	NADPH oxidase 1	Rattus norvegicus	182-186
28703832-8	2017	The in vivo pre-treatment with 5 mg kg-1 of the flavonoid quercitrin reverts both the early hyporesponse of mesenteric arteries to noradrenaline and the up-regulation of iNOS, COX2, NOX1, TNFalpha and IL1beta in colitic rats.	Flavonoids	48-57	tumor necrosis factor	Rattus norvegicus	188-196
28703832-8	2017	The in vivo pre-treatment with 5 mg kg-1 of the flavonoid quercitrin reverts both the early hyporesponse of mesenteric arteries to noradrenaline and the up-regulation of iNOS, COX2, NOX1, TNFalpha and IL1beta in colitic rats.	Flavonoids	48-57	interleukin 1 beta	Rattus norvegicus	201-208
28299441-4	2017	Flavonoids synthesis is regulated by the MBW transcriptional complex, made of R2R3MYB, bHLH and WD40 proteins, with the MYB components liable for channeling the complex towards specific branches of the pathway.	Flavonoids	0-10	myb-related protein 3R-1-like	Nicotiana tabacum	82-85
27494802-4	2017	In this study, an attempt has been made to screen compounds from flavonoids and extended flavonoids libraries targeting acetylated lysine (KAc) binding site of BD1 of Brd4 using docking and molecular dynamics simulations.	Flavonoids	65-75	bromodomain containing 4	Homo sapiens	167-171
27494802-4	2017	In this study, an attempt has been made to screen compounds from flavonoids and extended flavonoids libraries targeting acetylated lysine (KAc) binding site of BD1 of Brd4 using docking and molecular dynamics simulations.	Flavonoids	89-99	bromodomain containing 4	Homo sapiens	167-171
27494802-8	2017	We have identified a flavonoid which shows docking and Glide e-model score comparatively much higher than those of already reported known inhibitors against Brd4.	Flavonoids	21-30	bromodomain containing 4	Homo sapiens	157-161
27494802-9	2017	The protein-ligand complex with top-ranked flavonoid was used for dynamics simulation study for 50 ns in order to validate its stability inside the active site of Brd4 receptor.	Flavonoids	43-52	bromodomain containing 4	Homo sapiens	163-167
28620995-1	2017	Flavonoid Tilianin was isolated from Dracocephalum moldavica, and its pharmacological mechanism on proliferation, migration and the TGF-beta/Smad signaling pathway in rat vascular smooth muscle cells (VSMCs) induced with Angiotensin II (Ang II) was systematically evaluated.	Flavonoids	0-9	angiotensinogen	Rattus norvegicus	221-235
28285192-1	2017	Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the amelioration of various inflammation- and oxidative stress-induced diseases, including acute lung injury (ALI).	Flavonoids	17-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
28516293-11	2017	The decreased peel flavonoid accumulation and gene transcription in response to UV-B suggest that hp-1 allele is involved in the marked down-regulation of the flavonoid biosynthesis observed in SA206 fruit.	Flavonoids	19-28	DNA damage-binding protein 1	Solanum lycopersicum	98-102
28516293-11	2017	The decreased peel flavonoid accumulation and gene transcription in response to UV-B suggest that hp-1 allele is involved in the marked down-regulation of the flavonoid biosynthesis observed in SA206 fruit.	Flavonoids	159-168	DNA damage-binding protein 1	Solanum lycopersicum	98-102
28516293-14	2017	This study provides, for the first time, evidence that the presence of the functional Aft allele, under UV-B radiation, redirects flavonoid synthesis towards anthocyanin production and suggests that the hp-1 allele negatively influences the response of flavonoid biosynthesis to UV-B.	Flavonoids	130-139	DNA damage-binding protein 1	Solanum lycopersicum	203-207
28516293-14	2017	This study provides, for the first time, evidence that the presence of the functional Aft allele, under UV-B radiation, redirects flavonoid synthesis towards anthocyanin production and suggests that the hp-1 allele negatively influences the response of flavonoid biosynthesis to UV-B.	Flavonoids	253-262	DNA damage-binding protein 1	Solanum lycopersicum	203-207
28742839-7	2017	Overall the flavonoids significantly reduced aortic atherosclerosis (SMD 1.10, 95% CI 0.69, 1.51).	Flavonoids	12-22	small nuclear ribonucleoprotein D1	Mus musculus	69-74
28742839-12	2017	Based on the included studies, the flavonols appear to be the most effective flavonoids for reducing aortic atherosclerotic lesion area in apolipoprotein E deficient mice.	Flavonoids	77-87	apolipoprotein E	Mus musculus	139-155
28559058-1	2017	Naturally-occurring flavonoids have well documented anti-aggregatory and neuroprotective properties against the hallmark toxic protein in Alzheimer"s disease, amyloid beta (Abeta).	Flavonoids	20-30	amyloid beta precursor protein	Rattus norvegicus	173-178
28648061-2	2017	However, manually processing acquired UHPLC-DAD-HRAM/MSn data for flavonoid analysis is very challenging and highly expertise-dependent due to the complexities of the chemical structures of the flavonoids and the food matrixes.	Flavonoids	66-75	moesin	Homo sapiens	53-56
28648061-2	2017	However, manually processing acquired UHPLC-DAD-HRAM/MSn data for flavonoid analysis is very challenging and highly expertise-dependent due to the complexities of the chemical structures of the flavonoids and the food matrixes.	Flavonoids	194-204	moesin	Homo sapiens	53-56
28648061-11	2017	FlavonQ-2.0v greatly facilitates the identification and quantitation of flavonoids from UHPLC-HRAM-MSn data.	Flavonoids	72-82	moesin	Homo sapiens	99-102
28720813-0	2017	A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells.	Flavonoids	17-26	mitogen-activated protein kinase 14	Homo sapiens	70-73
28720813-0	2017	A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells.	Flavonoids	17-26	mitogen-activated protein kinase 8	Homo sapiens	74-77
28653733-3	2017	The total phenolic content, flavonoid content and antioxidative activities of OBP extracts significantly increased on heat treatment.	Flavonoids	28-37	odorant binding protein 2A	Homo sapiens	78-81
28559058-2	2017	However the extensive diversity of flavonoids has limited the insight into the precise structure-activity relationships that confer such bioactive properties against the Abeta protein.	Flavonoids	35-45	amyloid beta precursor protein	Rattus norvegicus	170-175
28698611-8	2017	In addition, flavonoids were found to be involved in pAkt - NF-kappaB signaling pathway through a reduction in phosphorylation of Akt.	Flavonoids	13-23	AKT serine/threonine kinase 1	Homo sapiens	54-57
28408246-14	2017	CONCLUSIONS: These results demonstrated that Huangkui capsule and the flavonoids components prevent tubulointerstitial fibrosis in CRF rat involvement in the action mechanism of inhibiting NADPH oxidase/ROS/ERK pathway.	Flavonoids	70-80	Eph receptor B1	Rattus norvegicus	207-210
28698611-7	2017	Flavonoids also significantly contributed in the retention of synaptic functions (VGLUT1 and GAD65) in cerebellar neurons.	Flavonoids	0-10	solute carrier family 17 member 7	Homo sapiens	82-88
28284041-1	2017	The Arabidopsis thaliana R2R3-MYB transcription factor MYB12 is a light-inducible, flavonol-specific activator of flavonoid biosynthesis.	Flavonoids	114-123	myb domain protein 12	Arabidopsis thaliana	55-60
28696372-0	2017	Warfarin and Flavonoids Do Not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin.	Flavonoids	13-23	albumin	Homo sapiens	102-115
28696372-1	2017	Human serum albumin (HSA) binds a variety of xenobiotics, including flavonoids and warfarin.	Flavonoids	68-78	albumin	Homo sapiens	6-25
28696372-3	2017	Studies dealing with flavonoid-induced warfarin displacement from HSA provided controversial results: estimated risk of displacement ranged from none to serious.	Flavonoids	21-30	albumin	Homo sapiens	66-69
28698624-1	2017	Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking endogenous TPCs.	Flavonoids	36-45	two pore segment channel 2	Homo sapiens	126-144
28696372-4	2017	To resolve these controversies, in vitro study of simultaneous binding of warfarin and eight different flavonoid aglycons and glycosides to HSA was carried out by fluorescence spectroscopy as well as molecular docking.	Flavonoids	103-112	albumin	Homo sapiens	140-143
28696372-5	2017	Results show that warfarin and flavonoids do not share the same binding region in binding to HSA.	Flavonoids	31-41	albumin	Homo sapiens	93-96
28696372-7	2017	Docking experiments show that flavonoid aglycons and glycosides do not bind at warfarin high affinity sites, but rather to different regions within the IIA HSA subdomain.	Flavonoids	30-39	albumin	Homo sapiens	156-159
28696372-8	2017	Thus, the risk of clinically significant warfarin-flavonoid interaction in binding to HSA should be regarded as negligible.	Flavonoids	50-59	albumin	Homo sapiens	86-89
28698611-7	2017	Flavonoids also significantly contributed in the retention of synaptic functions (VGLUT1 and GAD65) in cerebellar neurons.	Flavonoids	0-10	glutamate decarboxylase 2	Homo sapiens	93-98
28698624-1	2017	Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking endogenous TPCs.	Flavonoids	36-45	two pore segment channel 2	Homo sapiens	146-150
28680100-0	2017	The Sulfoquinovosyltransferase-like Enzyme SQD2.2 is Involved in Flavonoid Glycosylation, Regulating Sugar Metabolism and Seed Setting in Rice.	Flavonoids	65-74	sulfoquinovosyldiacylglycerol 2	Arabidopsis thaliana	43-47
28680100-2	2017	In this study, a sulfoquinovosyl transferase-like protein, designated as SQD2.2 involved in seed setting and flavonoid accumulation, was identified and characterized in rice.	Flavonoids	109-118	sulfoquinovosyldiacylglycerol 2	Arabidopsis thaliana	73-77
28680100-8	2017	Taken together, rice SQD2.2 exhibits a novel role in flavonoid synthesis and plays an important role in mediating sugar allocation between primary and secondary metabolism in rice.	Flavonoids	53-62	sulfoquinovosyldiacylglycerol 2	Arabidopsis thaliana	21-25
28508231-3	2017	Moreover, the scope of ligands that bind the AhR includes endogenous compounds such as multiple tryptophan metabolites, other endogenous biochemicals, pharmaceuticals and health-promoting phytochemicals including flavonoids, indole-3-carbinol and its metabolites.	Flavonoids	213-223	aryl hydrocarbon receptor	Homo sapiens	45-48
28235660-6	2017	Polyphenols including flavonoids, phenolic acids, phenolic alcohols, stilbenes and lignans, can target TLR4 signaling pathways in multiple ways.	Flavonoids	22-32	toll like receptor 4	Homo sapiens	103-107
28511119-2	2017	In addition, the bioactivities of its total flavonoids-breviscapine included inhibiting amyloid beta (Abeta) fibril formation, antioxidation and metal chelating, which are beneficial to treat Alzheimer"s disease (AD).	Flavonoids	44-54	amyloid beta (A4) precursor protein	Mus musculus	102-107
28452066-0	2017	Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects.	Flavonoids	86-96	anoctamin 1, calcium activated chloride channel	Mus musculus	14-38
28452066-0	2017	Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects.	Flavonoids	86-95	anoctamin 1, calcium activated chloride channel	Mus musculus	14-38
28452066-5	2017	In this study, we screened a broad spectrum of flavonoids for their inhibitory activities on TMEM16A currents.	Flavonoids	47-57	anoctamin 1, calcium activated chloride channel	Mus musculus	93-100
28452066-10	2017	To examine the physiological relevance of these findings, we also studied the effects of these flavonoids on endogenous TMEM16A currents in addition to cell proliferation and migration in LA795 cancer cells.	Flavonoids	95-105	anoctamin 1, calcium activated chloride channel	Mus musculus	120-127
28452066-11	2017	Among the flavonoids tested, we detected a highly significant correlation between TMEM16A current inhibition and cell proliferation or reduction of migration.	Flavonoids	10-20	anoctamin 1, calcium activated chloride channel	Mus musculus	82-89
28452066-12	2017	CONCLUSIONS AND IMPLICATIONS: This study demonstrates that flavonoids inhibit TMEM16A currents and suggests that flavonoids could have anticancer effects via this mechanism.	Flavonoids	59-69	anoctamin 1, calcium activated chloride channel	Mus musculus	78-85
28452066-12	2017	CONCLUSIONS AND IMPLICATIONS: This study demonstrates that flavonoids inhibit TMEM16A currents and suggests that flavonoids could have anticancer effects via this mechanism.	Flavonoids	113-123	anoctamin 1, calcium activated chloride channel	Mus musculus	78-85
28422384-9	2017	Both flavonoids induced marked improvement in paw licking time, paw edema %, malondialdehyde content, superoxide dismutase, and sorbitol dehydrogenase activities, with slight progress in paw interlukin-1beta.	Flavonoids	5-15	sorbitol dehydrogenase	Mus musculus	128-150
29039326-6	2017	The two flavonoids activated caspase-8, which cleaved Bid into tBid; simultaneously, Bax transferred from cytosol into mitochondria to decrease MMP; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis.	Flavonoids	8-18	caspase 8	Homo sapiens	29-38
28979070-5	2017	Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme.	Flavonoids	52-62	sucrase-isomaltase	Homo sapiens	184-201
29039326-6	2017	The two flavonoids activated caspase-8, which cleaved Bid into tBid; simultaneously, Bax transferred from cytosol into mitochondria to decrease MMP; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis.	Flavonoids	8-18	BH3 interacting domain death agonist	Homo sapiens	54-57
29039326-6	2017	The two flavonoids activated caspase-8, which cleaved Bid into tBid; simultaneously, Bax transferred from cytosol into mitochondria to decrease MMP; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis.	Flavonoids	8-18	BCL2 associated X, apoptosis regulator	Homo sapiens	85-88
29039326-6	2017	The two flavonoids activated caspase-8, which cleaved Bid into tBid; simultaneously, Bax transferred from cytosol into mitochondria to decrease MMP; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis.	Flavonoids	8-18	cytochrome c, somatic	Homo sapiens	166-178
29039326-6	2017	The two flavonoids activated caspase-8, which cleaved Bid into tBid; simultaneously, Bax transferred from cytosol into mitochondria to decrease MMP; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis.	Flavonoids	8-18	caspase 9	Homo sapiens	216-225
29039326-6	2017	The two flavonoids activated caspase-8, which cleaved Bid into tBid; simultaneously, Bax transferred from cytosol into mitochondria to decrease MMP; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis.	Flavonoids	8-18	caspase 9	Homo sapiens	236-245
29039326-6	2017	The two flavonoids activated caspase-8, which cleaved Bid into tBid; simultaneously, Bax transferred from cytosol into mitochondria to decrease MMP; consequentially, cytochrome c released from mitochondria activated caspase-9, and then caspase-9 activated caspase-3, which executed the apoptosis.	Flavonoids	8-18	caspase 3	Homo sapiens	256-265
28545670-13	2017	CONCLUSION: Pre-treatment of RAW 264.7 cells with the five flavonoids inhibited MNoV by upregulating the expression of antiviral cytokines (IFN-alpha, IFN-lambda, and TNF-alpha) and interferon-stimulating genes (Mx and ZAP).	Flavonoids	59-69	interferon alpha	Mus musculus	140-149
28288492-2	2017	The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking.The flavones apigenin, luteolin, and their respective glucosides have good ability to interact with metalloproteases and can also be lead compounds for further development.	Flavonoids	11-20	matrix metallopeptidase 1	Homo sapiens	405-410
28545670-13	2017	CONCLUSION: Pre-treatment of RAW 264.7 cells with the five flavonoids inhibited MNoV by upregulating the expression of antiviral cytokines (IFN-alpha, IFN-lambda, and TNF-alpha) and interferon-stimulating genes (Mx and ZAP).	Flavonoids	59-69	tumor necrosis factor	Mus musculus	167-176
28545670-13	2017	CONCLUSION: Pre-treatment of RAW 264.7 cells with the five flavonoids inhibited MNoV by upregulating the expression of antiviral cytokines (IFN-alpha, IFN-lambda, and TNF-alpha) and interferon-stimulating genes (Mx and ZAP).	Flavonoids	59-69	zinc finger CCCH type, antiviral 1	Mus musculus	219-222
28545670-5	2017	STUDY DESIGN: Based on the antiviral activity of the five flavonoids, recently reported by our group, the expression of antiviral factors such as IFN-alpha, IFN-lambda, TNF-alpha, IL-1beta, IL-6, Mx, ZAP, OAS, and iNOS was investigated in RAW 264.7 cells pre-treated with these flavonoids.	Flavonoids	58-68	interferon alpha	Mus musculus	146-155
28545670-5	2017	STUDY DESIGN: Based on the antiviral activity of the five flavonoids, recently reported by our group, the expression of antiviral factors such as IFN-alpha, IFN-lambda, TNF-alpha, IL-1beta, IL-6, Mx, ZAP, OAS, and iNOS was investigated in RAW 264.7 cells pre-treated with these flavonoids.	Flavonoids	58-68	interleukin 1 beta	Mus musculus	180-188
28808394-9	2017	Furthermore, the flavonoid showed a high antiproliferative activity on LS 180 and HeLa with IC50 values of 62.2 and 71.9 muM, respectively.	Flavonoids	17-26	latexin	Homo sapiens	121-124
28288492-2	2017	The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking.The flavones apigenin, luteolin, and their respective glucosides have good ability to interact with metalloproteases and can also be lead compounds for further development.	Flavonoids	11-20	matrix metallopeptidase 3	Homo sapiens	412-417
28288492-2	2017	The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking.The flavones apigenin, luteolin, and their respective glucosides have good ability to interact with metalloproteases and can also be lead compounds for further development.	Flavonoids	11-20	matrix metallopeptidase 13	Homo sapiens	419-425
28288492-2	2017	The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking.The flavones apigenin, luteolin, and their respective glucosides have good ability to interact with metalloproteases and can also be lead compounds for further development.	Flavonoids	11-20	matrix metallopeptidase 8	Homo sapiens	427-432
28288492-2	2017	The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking.The flavones apigenin, luteolin, and their respective glucosides have good ability to interact with metalloproteases and can also be lead compounds for further development.	Flavonoids	11-20	matrix metallopeptidase 9	Homo sapiens	438-443
28706418-18	2017	NAR prevented Smad3 phosphorylation in the linker region by JNK since this flavonoid blocked this kinase (P &lt; 0.05).	Flavonoids	75-84	SMAD family member 3	Rattus norvegicus	14-19
28665801-1	2017	We present a new and simpler regression model for the estimation of the first oxidation potentials (Ep1) of flavonoids based on the number of phenolic, alcoholic, and carboxylic OH groups.	Flavonoids	108-118	prostaglandin E receptor 1	Homo sapiens	100-103
28706418-18	2017	NAR prevented Smad3 phosphorylation in the linker region by JNK since this flavonoid blocked this kinase (P &lt; 0.05).	Flavonoids	75-84	mitogen-activated protein kinase 8	Rattus norvegicus	60-63
28638078-5	2017	Using drug screening in C. elegans nematodes with neuronal expression of human exon-1 huntingtin (128Q), we found that 3ss-Methoxy-Pregnenolone (MAP4343), 17ss-oestradiol (17ssE2) and 12 flavonoids including isoquercitrin promote neuronal function in 128Q nematodes.	Flavonoids	187-197	huntingtin	Homo sapiens	86-96
28620169-0	2017	Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin.	Flavonoids	101-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
28366538-3	2017	In this study, we hypothesize that morin, a bioflavonoid, mediates its anti-cancer effect through the activation of Mst1/hippo signaling in liver cancer cells.	Flavonoids	44-56	macrophage stimulating 1	Homo sapiens	116-120
28445133-1	2017	Baicalein, a natural flavonoid, is structurally advantageous for binding to xanthine oxidoreductase.	Flavonoids	21-30	xanthine dehydrogenase	Mus musculus	76-99
28620169-3	2017	In present study, we have performed detailed biophysical studies for the interaction of human c-myc G-quadruplex DNA with nine representative flavonoids: Luteolin, Quercetin, Rutin, Genistein, Kaempferol, Puerarin, Hesperidin, Myricetin and Daidzein.	Flavonoids	142-152	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
28620169-8	2017	This study emphasizes the potential of flavonoids as a promising candidate for targeting c-myc promoter region and thus, could act as a potential anti-cancer agent.	Flavonoids	39-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	89-94
28608828-2	2017	We found that flavonoids including kaempferol, chrysin, and luteolin concentration-dependently decrease claudin-2 expression in lung adenocarcinoma A549 cells.	Flavonoids	14-24	claudin 2	Homo sapiens	104-113
28574574-4	2017	Quercetin, a flavonoid, stimulates Na+ -K+ -2Cl- cotransporter 1 (NKCC1), which is one of the most important ion transporters regulating the cytosolic Cl- concentration ([Cl- ]c ).	Flavonoids	13-22	solute carrier family 12 member 2	Homo sapiens	35-64
28574574-4	2017	Quercetin, a flavonoid, stimulates Na+ -K+ -2Cl- cotransporter 1 (NKCC1), which is one of the most important ion transporters regulating the cytosolic Cl- concentration ([Cl- ]c ).	Flavonoids	13-22	solute carrier family 12 member 2	Homo sapiens	66-71
28632894-2	2017	In vitro, flavonoids predominantly inhibit the major phase I drug-metabolizing enzyme CYP450 3A4 and the enzymes responsible for the bioactivation of procarcinogens (CYP1 enzymes) and upregulate the enzymes involved in carcinogen detoxification (UDP-glucuronosyltransferases, glutathione S-transferases (GSTs)).	Flavonoids	10-20	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	166-170
28632894-3	2017	Flavonoids have been reported to inhibit ATP-binding cassette (ABC) transporters (multidrug resistance (MDR)-associated proteins, breast cancer-resistance protein) that contribute to the development of MDR.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	130-162
28632894-4	2017	P-glycoprotein, an ABC transporter that limits drug bioavailability and also induces MDR, was differently modulated by flavonoids.	Flavonoids	119-129	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
28058739-1	2017	This study aims to investigate the interaction between 3 flavonoids (quercetin, apigenin, and naringenin) and fat mass and obesity-associated protein by fluorescence, ultraviolet-visible absorption spectroscopy, and molecular modeling.	Flavonoids	57-67	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	110-149
28364599-0	2017	Flavonoids from Enicostema littorale blume enhances glucose uptake of cells in insulin resistant human liver cancer (HepG2) cell line via IRS-1/PI3K/Akt pathway.	Flavonoids	0-10	insulin	Homo sapiens	79-86
28364599-0	2017	Flavonoids from Enicostema littorale blume enhances glucose uptake of cells in insulin resistant human liver cancer (HepG2) cell line via IRS-1/PI3K/Akt pathway.	Flavonoids	0-10	insulin receptor substrate 1	Homo sapiens	138-143
28364599-0	2017	Flavonoids from Enicostema littorale blume enhances glucose uptake of cells in insulin resistant human liver cancer (HepG2) cell line via IRS-1/PI3K/Akt pathway.	Flavonoids	0-10	AKT serine/threonine kinase 1	Homo sapiens	149-152
28058739-2	2017	Results indicate that the intrinsic fluorescence of fat mass and obesity-associated protein can be quenched by the 3 flavonoids through a static quenching procedure.	Flavonoids	117-127	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	52-91
30087790-3	2017	To address the anti-inflammatory role of flavonoids, in the present study, we investigated the effects of the flavonoids quercetin and vitexin on the stimulus-induced nitric oxide (NO), TNF-alpha, and MPO productions in human neutrophils.	Flavonoids	110-120	myeloperoxidase	Homo sapiens	201-204
28472605-0	2017	Total Flavonoid Extract from Abelmoschus manihot (L.) Medic Flowers Attenuates d-Galactose-Induced Oxidative Stress in Mouse Liver Through the Nrf2 Pathway.	Flavonoids	6-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	143-147
28400288-14	2017	CONCLUSION: The flavonoid-rich fraction of O. gratissimum leaves demonstrated anti-inflammatory activity via mechanisms that involves inhibition of leucocytes influx, NO, IL-1beta, and TNF-alpha in vivo and in vitro, thus supporting its therapeutic potential in slowing down inflammatory processes in chronic diseases.	Flavonoids	16-25	interleukin 1 beta	Mus musculus	171-179
28414916-3	2017	Upon screening several natural chemicals, we found that a dietary flavonoid, quercetin, significantly suppresses Wnt16 expression in activated fibroblasts.	Flavonoids	66-75	Wnt family member 16	Homo sapiens	113-118
28400288-14	2017	CONCLUSION: The flavonoid-rich fraction of O. gratissimum leaves demonstrated anti-inflammatory activity via mechanisms that involves inhibition of leucocytes influx, NO, IL-1beta, and TNF-alpha in vivo and in vitro, thus supporting its therapeutic potential in slowing down inflammatory processes in chronic diseases.	Flavonoids	16-25	tumor necrosis factor	Mus musculus	185-194
28236705-11	2017	These findings revealed that total flavonoids in Caragana can protect BMECs from H/R-induced injury in a dose-dependent manner and it also may promote angiogenesis in BMECs by activating HIF- 1alpha-VEGF-Notch 1 signaling pathway.	Flavonoids	35-45	vascular endothelial growth factor A	Homo sapiens	199-203
28830101-4	2017	Interestingly tt16 and tt15 mutants display a very similar flavonoid profiles and patterns of PA accumulation.	Flavonoids	59-68	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	14-18
28830101-4	2017	Interestingly tt16 and tt15 mutants display a very similar flavonoid profiles and patterns of PA accumulation.	Flavonoids	59-68	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	23-27
28504712-0	2017	Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults.	Flavonoids	0-9	C-reactive protein	Homo sapiens	58-76
28504712-5	2017	Adults in the highest quartile of flavonoid intake had significantly lower body mass index and waist circumference than those in the lowest quartile of flavonoid intake (P&lt;0.03 and P&lt;0.04, respectively), and flavonoid intake was inversely related to C-reactive protein levels in women (p-trend, 0.01).	Flavonoids	34-43	C-reactive protein	Homo sapiens	256-274
28472886-2	2017	With Pd(PPh3)4/Xphos as the catalyst and K2CO3 as the base, this protocol was applied to synthesize a small library of diversely functionalized flavonoids in moderate to good yields in 1,4-dioxane.	Flavonoids	144-154	caveolin 1	Homo sapiens	8-12
28069121-1	2017	Flavonoids are an important type of natural tyrosinase inhibitor, but their inhibitory activity and mechanism against tyrosinase are very different because of their different structures.	Flavonoids	0-10	tyrosinase	Homo sapiens	44-54
28069121-1	2017	Flavonoids are an important type of natural tyrosinase inhibitor, but their inhibitory activity and mechanism against tyrosinase are very different because of their different structures.	Flavonoids	0-10	tyrosinase	Homo sapiens	118-128
28317253-0	2017	Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity.	Flavonoids	35-45	cytochrome c, somatic	Homo sapiens	50-62
28317253-1	2017	There are large differences between flavonoids to protect against apoptosis, a process in which cytochrome c (Cyt c) plays a key role.	Flavonoids	36-46	cytochrome c, somatic	Homo sapiens	96-108
28317253-1	2017	There are large differences between flavonoids to protect against apoptosis, a process in which cytochrome c (Cyt c) plays a key role.	Flavonoids	36-46	cytochrome c, somatic	Homo sapiens	110-115
28317253-2	2017	In this work, we show that 7 of 13 flavonoids studied have a capacity to reduce Cyt c similar or higher than ascorbate, the flavonols quercetin, kaempferol and myricetin, flavanol epigallocatechin-gallate, anthocyanidins cyanidin and malvidin, and the flavone luteolin.	Flavonoids	35-45	cytochrome c, somatic	Homo sapiens	80-85
28317253-5	2017	However, the CL-induced loss of Cyt c Soret band intensity was largely attenuated by flavonoids, pointing out a stabilizing action against Cyt c unfolding in the complex.	Flavonoids	85-95	cytochrome c, somatic	Homo sapiens	139-144
28317253-6	2017	Moreover, flavonoids that behave as Cyt c reductants also inhibited the pro-apoptotic CL-induced peroxidase activity of Cyt c, indicating that modulation of Cyt c signaling are probable mechanisms behind the protective biological activities of flavonoids.	Flavonoids	10-20	cytochrome c, somatic	Homo sapiens	36-41
28317253-6	2017	Moreover, flavonoids that behave as Cyt c reductants also inhibited the pro-apoptotic CL-induced peroxidase activity of Cyt c, indicating that modulation of Cyt c signaling are probable mechanisms behind the protective biological activities of flavonoids.	Flavonoids	10-20	cytochrome c, somatic	Homo sapiens	120-125
28317253-6	2017	Moreover, flavonoids that behave as Cyt c reductants also inhibited the pro-apoptotic CL-induced peroxidase activity of Cyt c, indicating that modulation of Cyt c signaling are probable mechanisms behind the protective biological activities of flavonoids.	Flavonoids	10-20	cytochrome c, somatic	Homo sapiens	120-125
28317253-6	2017	Moreover, flavonoids that behave as Cyt c reductants also inhibited the pro-apoptotic CL-induced peroxidase activity of Cyt c, indicating that modulation of Cyt c signaling are probable mechanisms behind the protective biological activities of flavonoids.	Flavonoids	244-254	cytochrome c, somatic	Homo sapiens	36-41
28317253-6	2017	Moreover, flavonoids that behave as Cyt c reductants also inhibited the pro-apoptotic CL-induced peroxidase activity of Cyt c, indicating that modulation of Cyt c signaling are probable mechanisms behind the protective biological activities of flavonoids.	Flavonoids	244-254	cytochrome c, somatic	Homo sapiens	120-125
28317253-6	2017	Moreover, flavonoids that behave as Cyt c reductants also inhibited the pro-apoptotic CL-induced peroxidase activity of Cyt c, indicating that modulation of Cyt c signaling are probable mechanisms behind the protective biological activities of flavonoids.	Flavonoids	244-254	cytochrome c, somatic	Homo sapiens	120-125
28192136-0	2017	Inhibition of glycation and aldose reductase activity using dietary flavonoids: A lens organ culture studies.	Flavonoids	68-78	aldose reductase	Bos taurus	28-44
28446542-2	2017	Chalcone synthase (CHS) catalyzes the first step of flavonoid biosynthesis by directing carbon flux from general phenylpropanoid metabolism to flavonoid pathway.	Flavonoids	52-61	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-17
28376352-2	2017	This study aims to identify the metabolic profile of five flavonoids (loureirin A, loureirin B, loureirin C, 7,4"-dihydroxyflavone and 5,7,4"-trihydroxyflavanone) from DB in HLMs as well as the CYP enzymes that are involved in the metabolism of them.	Flavonoids	58-68	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	194-197
28443720-9	2017	The induction of the expression of MMP-3 and the downregulation of MCP-1 might result in an antiplatelet activity that was not observed for the micronized purified flavonoid fraction.	Flavonoids	164-173	matrix metallopeptidase 3	Homo sapiens	35-40
28443720-9	2017	The induction of the expression of MMP-3 and the downregulation of MCP-1 might result in an antiplatelet activity that was not observed for the micronized purified flavonoid fraction.	Flavonoids	164-173	C-C motif chemokine ligand 2	Homo sapiens	67-72
28446542-2	2017	Chalcone synthase (CHS) catalyzes the first step of flavonoid biosynthesis by directing carbon flux from general phenylpropanoid metabolism to flavonoid pathway.	Flavonoids	143-152	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-17
28237818-3	2017	Here we report that quercetin, a plant flavonoid, which is known for its neuroprotective effect, reversibly inhibits homomeric rat ASIC1a, ASIC2a and ASIC3 with an IC50 of about 2microM.	Flavonoids	39-48	acid sensing ion channel subunit 3	Rattus norvegicus	150-155
27996361-4	2017	Thus, the applied preliminary structure-based molecular modeling approach of interactions between NBD2 and flavonoids may be gainful to realize the intimate inhibition mechanism of P-gp at NBD2 level and on the basis of the obtained data, it can be concluded that these bioflavonoids have the potential to cause herb-drug interactions or be used as lead molecules for the inhibition of P-gp (as anti-multidrug resistance agents) via the NBD2 blocking mechanism in future.	Flavonoids	107-117	phosphoglycolate phosphatase	Mus musculus	181-185
27996361-4	2017	Thus, the applied preliminary structure-based molecular modeling approach of interactions between NBD2 and flavonoids may be gainful to realize the intimate inhibition mechanism of P-gp at NBD2 level and on the basis of the obtained data, it can be concluded that these bioflavonoids have the potential to cause herb-drug interactions or be used as lead molecules for the inhibition of P-gp (as anti-multidrug resistance agents) via the NBD2 blocking mechanism in future.	Flavonoids	107-117	phosphoglycolate phosphatase	Mus musculus	386-390
28361543-3	2017	Here we showed that (-)-epigallocatechin gallate (EGCG), the main flavonoid present in green tea, dose-dependently inhibited MPO-mediated HOCl formation in vitro (chlorinating activities of MPO: 50.2 +- 5.7% for 20 muM EGCG versus 100 +- 5.6% for control, P &lt; 0.01).	Flavonoids	66-75	myeloperoxidase	Homo sapiens	125-128
28277581-0	2017	Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.	Flavonoids	8-18	ubiquitin conjugating enzyme E2 S	Homo sapiens	96-101
28361543-5	2017	This flavonoid also effectively inhibited HOCl generation in activated neutrophils (HOCl formation: 65.0 +- 5.6% for 20 muM EGCG versus 100 +- 6.2% for control, P &lt; 0.01) without influencing MPO and Nox2 release and superoxide formation, suggesting that EGCG specifically inhibited MPO but not NADPH oxidase activity in activated neutrophils.	Flavonoids	5-14	myeloperoxidase	Homo sapiens	194-197
28361543-5	2017	This flavonoid also effectively inhibited HOCl generation in activated neutrophils (HOCl formation: 65.0 +- 5.6% for 20 muM EGCG versus 100 +- 6.2% for control, P &lt; 0.01) without influencing MPO and Nox2 release and superoxide formation, suggesting that EGCG specifically inhibited MPO but not NADPH oxidase activity in activated neutrophils.	Flavonoids	5-14	cytochrome b-245 beta chain	Homo sapiens	202-206
28361543-5	2017	This flavonoid also effectively inhibited HOCl generation in activated neutrophils (HOCl formation: 65.0 +- 5.6% for 20 muM EGCG versus 100 +- 6.2% for control, P &lt; 0.01) without influencing MPO and Nox2 release and superoxide formation, suggesting that EGCG specifically inhibited MPO but not NADPH oxidase activity in activated neutrophils.	Flavonoids	5-14	myeloperoxidase	Homo sapiens	285-288
28330723-9	2017	RESULTS: The chromatographic profile of AEPp indicated the presence of flavonoids, coumarins and hydrolyzable and condensed tannins.	Flavonoids	71-81	immunoglobulin mu DNA binding protein 2	Rattus norvegicus	40-44
28257977-8	2017	Hypoglycemic effects of fruits and vegetables may be due to their inducing nature on pancreatic beta-cells for insulin secretion, or bioactive compounds such as flavonoids, alkaloids and anthocyanins, which act as insulin-like molecules or insulin secretagogues.	Flavonoids	161-171	insulin	Homo sapiens	214-221
28259840-3	2017	Flavonoids have a compact rigid skeleton which fit precisely within the binding cavity of CYP1B1.	Flavonoids	0-10	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	90-96
28259840-4	2017	Systematic isosteric replacement of flavonoid "O" atom with "N" atom led to the prediction that a "quinazoline" scaffold could be the basis for designing potential CYP1B1 inhibitors.	Flavonoids	36-45	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	164-170
28903343-0	2017	A study on the anti-tumor mechanism of total flavonoids from Radix Tetrastigmae against additional cell line based on COX-2-mediated Wnt/beta-catenin signaling pathway.	Flavonoids	45-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
28903343-0	2017	A study on the anti-tumor mechanism of total flavonoids from Radix Tetrastigmae against additional cell line based on COX-2-mediated Wnt/beta-catenin signaling pathway.	Flavonoids	45-55	catenin beta 1	Homo sapiens	137-149
28135601-5	2017	Furthermore, the inhibitory effects of these flavonoids on CYP2C9 enzyme were tested because the metabolic elimination of warfarin is catalysed principally by this enzyme.	Flavonoids	45-55	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	59-65
28107698-0	2017	The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy.	Flavonoids	12-21	CD44 molecule (Indian blood group)	Homo sapiens	48-52
28135601-6	2017	Herein, we demonstrate that each tested flavonoid metabolite can bind to human serum albumin (HSA) with high affinity, some with similar or even higher affinity than quercetin itself.	Flavonoids	40-49	albumin	Homo sapiens	79-92
27754592-2	2017	All analyzed flavonoids showed inhibitory effects against hDPP III with the IC50 values ranging from 22.0 to 437.2 mum.	Flavonoids	13-23	dipeptidyl peptidase 3	Homo sapiens	58-66
27637378-0	2017	Construction of explicit models to correlate the structure and the inhibitory activity of aldose reductase: Flavonoids and sulfonyl-pyridazinones as inhibitors.	Flavonoids	108-118	aldo-keto reductase family 1 member B	Homo sapiens	90-106
27754592-0	2017	Validation of flavonoids as potential dipeptidyl peptidase III inhibitors: Experimental and computational approach.	Flavonoids	14-24	dipeptidyl peptidase 3	Homo sapiens	38-62
28235721-0	2017	Characterization and structure-activity relationship of natural flavonoids as hERG K+ channel modulators.	Flavonoids	64-74	ETS transcription factor ERG	Homo sapiens	78-82
27754592-1	2017	Fifteen flavonoids were studied for their inhibitory activity against human dipeptidyl peptidase III (hDPP III) combining an in vitro assay with an in silico molecular modeling study.	Flavonoids	8-18	dipeptidyl peptidase 3	Homo sapiens	76-100
27754592-1	2017	Fifteen flavonoids were studied for their inhibitory activity against human dipeptidyl peptidase III (hDPP III) combining an in vitro assay with an in silico molecular modeling study.	Flavonoids	8-18	dipeptidyl peptidase 3	Homo sapiens	102-110
27637378-3	2017	We constructed two explicit models to correlate the binding energies with the inhibitory activities of flavonoids and sulfonyl-pyridazinones as inhibitors of aldose reductase.	Flavonoids	103-113	aldo-keto reductase family 1 member B	Homo sapiens	158-174
28229939-3	2017	Flavonoids (1-9) (100muM), compared to silybin, significantly reduced the cellular damage caused by CCl4 in rat hepatocytes, preserved cell viability and GSH level, decreased LDH leakage and reduced lipid damage.	Flavonoids	0-10	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
28235721-2	2017	We found that quercetin, fisetin, and some related flavonoid derivatives could inhibit human ether-a-go-go-related gene (hERG) K+ channels.	Flavonoids	51-60	ETS transcription factor ERG	Homo sapiens	121-125
28235721-3	2017	KEY FINDINGS: In this study, we tested the effects of a series of flavonoids on the hERG K+ channel expressed in HEK293 cells.	Flavonoids	66-76	ETS transcription factor ERG	Homo sapiens	84-88
28235721-8	2017	CONCLUSION: These results suggest that quercetin, fisetin, and luteolin are potent hERG K+ channel inhibitors and reveal the structure-activity relationship of natural flavonoids.	Flavonoids	168-178	ETS transcription factor ERG	Homo sapiens	83-87
27915399-2	2017	Naringenin is a citrus flavonoid with anti-inflammatory actions, which has been shown to prevent obesity-related diseases and to activate PPARgamma.	Flavonoids	23-32	peroxisome proliferator activated receptor gamma	Mus musculus	138-147
28043654-0	2017	Selected flavonoid compounds as promising inhibitors of protein kinase CK2alpha and CK2alpha", the catalytic subunits of CK2.	Flavonoids	9-18	casein kinase 2 alpha 2	Homo sapiens	71-79
28043654-0	2017	Selected flavonoid compounds as promising inhibitors of protein kinase CK2alpha and CK2alpha", the catalytic subunits of CK2.	Flavonoids	9-18	casein kinase 2 alpha 2	Homo sapiens	84-92
28273931-7	2017	In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and CYP1A1 genetic variants.	Flavonoids	37-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	126-132
28539723-10	2017	Flavonoids in the ECCF were found to contain bergenin, quercitrin, and quercetin with reported anti-inflammatory activity via suppressing tumor necrosis factor-alpha production.	Flavonoids	0-10	tumor necrosis factor	Mus musculus	138-165
27989880-7	2017	Total flavonoids of purified methanol extracts of Spatholobi Caulis (PSC) were determined using ultraviolet spectrophotometry.	Flavonoids	6-16	PSC	Homo sapiens	69-72
27989880-17	2017	In addition, quality evaluation experiments showed that the content of total flavonoids of PSC reached 56.36% and the main pro-angiogenic fractions of PSC were F3, F4 and F5 both in zebrafish and HUVECs.	Flavonoids	77-87	PSC	Homo sapiens	91-94
28337212-8	2017	Finally, we generated transgenic spruce cell lines overexpressing four of the Norway spruce AtTT2 homologs and observed differential regulation of genes in the flavonoid pathway and flavonoid contents.	Flavonoids	160-169	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	92-97
28337212-8	2017	Finally, we generated transgenic spruce cell lines overexpressing four of the Norway spruce AtTT2 homologs and observed differential regulation of genes in the flavonoid pathway and flavonoid contents.	Flavonoids	182-191	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	92-97
25897647-5	2017	Interestingly, flavonoids have been found to have positive effects on lipid metabolism, insulin resistance, inflammation, and oxidative stress, the most important pathophysiological pathways in NAFLD.	Flavonoids	15-25	insulin	Homo sapiens	88-95
28107780-5	2017	Furthermore, two putative flavonoid-related genes encoding R2R3-MYB transcription factors, designated MYB12 and MYB22, were cloned and characterized.	Flavonoids	26-35	transcription repressor MYB5	Malus domestica	102-107
28107780-5	2017	Furthermore, two putative flavonoid-related genes encoding R2R3-MYB transcription factors, designated MYB12 and MYB22, were cloned and characterized.	Flavonoids	26-35	LOW QUALITY PROTEIN: transcription factor MYB11	Malus domestica	112-117
28408867-5	2017	It has been shown that the flavonoid myricetin arrests soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE)-mediated vesicle fusion at hemifusion, but that the hemifused vesicles spontaneously convert to full fusion when the myricetin clamp is removed by the enzyme laccase.	Flavonoids	27-36	small NF90 (ILF3) associated RNA E	Homo sapiens	132-137
28400785-0	2017	Dihydroflavonol 4-Reductase Genes from Freesia hybrida Play Important and Partially Overlapping Roles in the Biosynthesis of Flavonoids.	Flavonoids	125-135	dihydroflavonol 4-reductase	Arabidopsis thaliana	0-27
28400785-13	2017	Therefore, it can be concluded that the DFR-like genes from F. hybrida have diverged during evolution to play partially overlapping roles in the flavonoid biosynthesis, and the results will contribute to the study of evolution of DFR gene families in angiosperms, especially for monocot plants.	Flavonoids	145-154	dihydroflavonol 4-reductase	Arabidopsis thaliana	40-43
28400785-13	2017	Therefore, it can be concluded that the DFR-like genes from F. hybrida have diverged during evolution to play partially overlapping roles in the flavonoid biosynthesis, and the results will contribute to the study of evolution of DFR gene families in angiosperms, especially for monocot plants.	Flavonoids	145-154	dihydroflavonol 4-reductase	Arabidopsis thaliana	230-233
28336971-4	2017	A natural flavonoid acacetin is then identified to be capable of modulating RARgamma-dependent AKT-p53 network.	Flavonoids	10-19	retinoic acid receptor gamma	Homo sapiens	76-84
28336971-4	2017	A natural flavonoid acacetin is then identified to be capable of modulating RARgamma-dependent AKT-p53 network.	Flavonoids	10-19	AKT serine/threonine kinase 1	Homo sapiens	95-98
28336971-4	2017	A natural flavonoid acacetin is then identified to be capable of modulating RARgamma-dependent AKT-p53 network.	Flavonoids	10-19	tumor protein p53	Homo sapiens	99-102
28298268-6	2017	Based on preclinical studies that used cell culture and rodent models, it appears that many flavonoids (e.g., anthocyanidins, flavonols, and flavone subclasses) influence RCT and HDL function beyond simple HDL cholesterol concentration by regulating cellular cholesterol efflux from macrophages and hepatic paraoxonase 1 expression and activity.	Flavonoids	92-102	paraoxonase 1	Homo sapiens	307-320
28017776-12	2017	This flavonoid, through its antioxidant proprieties, might potentially exert an antithrombotic activity by inhibiting TF expression/activity in a cell population never investigated before in this context and that is normally represented in vessel wall such as endothelial cells.	Flavonoids	5-14	coagulation factor III, tissue factor	Homo sapiens	118-120
28213287-3	2017	In this study, we report the identification of butein, a flavonoid chalcone, as a novel inducer of HO-1 expression in adipocytes in vitro and in vivo.	Flavonoids	57-66	heme oxygenase 1	Mus musculus	99-103
28287469-4	2017	STH from the Berchidda area showed the highest amount of phenolic, flavonoid, amino acid and protein content, and antioxidant capacity compared to MH.	Flavonoids	67-76	saitohin	Homo sapiens	0-3
29624241-0	2017	POTENTIOMETRIC STUDY OF Pd(II) COMPLEXES OF SOME FLAVONOIDS IN WATER-METHANOL-1,4-DIOXANE-ACETONITRILE (MDM) MIXTURE.	Flavonoids	49-59	secreted LY6/PLAUR domain containing 1	Homo sapiens	104-107
29624241-5	2017	Obtained results provide evidence to show that investigated flavonoids in water-MDM solutions form with Pd(II) complexes of composition ML and MI..	Flavonoids	60-70	secreted LY6/PLAUR domain containing 1	Homo sapiens	80-83
28121480-2	2017	Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia.	Flavonoids	13-22	butyrylcholinesterase	Rattus norvegicus	60-81
28126414-7	2017	Furthermore, the structural information and inhibitory capacities of all reported hCEs inhibitors including fatty acids, flavonoids, tanshinones and triterpenoids have been systematically summarized.	Flavonoids	121-131	cat eye syndrome chromosome region	Homo sapiens	82-86
28092862-0	2017	Protective effects of total flavonoids of Astragalus against adjuvant-induced arthritis in rats by regulating OPG/RANKL/NF-kappaB pathway.	Flavonoids	28-38	TNF receptor superfamily member 11B	Rattus norvegicus	110-113
28092862-0	2017	Protective effects of total flavonoids of Astragalus against adjuvant-induced arthritis in rats by regulating OPG/RANKL/NF-kappaB pathway.	Flavonoids	28-38	TNF superfamily member 11	Rattus norvegicus	114-119
28121480-2	2017	Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia.	Flavonoids	13-22	butyrylcholinesterase	Rattus norvegicus	83-88
28454311-1	2017	Licochalcone A (LCA) is a flavonoid extracted from licorice root that has antiparasitic, antibacterial and antitumor properties.	Flavonoids	26-35	clathrin light chain A	Homo sapiens	16-19
28102022-0	2017	The Flavonoid 7,4"-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts.	Flavonoids	4-13	C-C motif chemokine ligand 11	Homo sapiens	89-96
28223414-0	2017	The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo.	Flavonoids	4-13	interleukin 17A	Mus musculus	54-69
28119082-4	2017	Herein, we investigated the inhibitory activity of fisetin and flavone against CYP1B1 using estrogen E2 as substrate in vitro to reveal structure-activity relationship between structure of flavonoids and inhibition.	Flavonoids	189-199	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	79-85
28119082-9	2017	Taken together the data suggested that fisetin is able to inhibit the formation of carcinogenic 4-OHE2 from E2, which reveals one of its anti-cancer mechanisms and helps to reveal the relationship between the structure of flavonoids and the inhibition CYP1B1 for discovering new drugs in cancer therapy and prevention.	Flavonoids	222-232	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	252-258
28119096-0	2017	Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice.	Flavonoids	45-55	apolipoprotein E	Mus musculus	97-101
28119096-2	2017	Hawthorn leave flavonoids (HLF) are the main part of extraction.	Flavonoids	15-25	hepatic leukemia factor	Mus musculus	27-30
28119096-19	2017	DISCUSSION AND CONCLUSION: Hawthorn leave flavonoids can slow down the development of atherosclerosis in apoE knockout mice via induced expression of genes involved in antioxidant activities, inhibition of the foam cell formation and promotion of RCT in vivo, which implies the potential use in the prevention of atherosclerosis.	Flavonoids	42-52	apolipoprotein E	Mus musculus	105-109
28128562-4	2017	In this work this assay was used together with docking and molecular dynamics simulations to analyze the anti-Abeta aggregation activity of several naturally occurring flavonoids and phenolic compounds.	Flavonoids	168-178	amyloid beta precursor protein	Homo sapiens	110-115
28223414-0	2017	The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo.	Flavonoids	4-13	interleukin 17 receptor A	Mus musculus	77-84
28088385-1	2017	Fla-CN (3-O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl] kaempferol) is a semi-synthesized flavonoid derivative of tiliroside which exhibited anti-diabetic effect in vivo.	Flavonoids	89-98	4-hydroxyphenylpyruvic acid dioxygenase	Mus musculus	0-3
28152057-4	2017	In this study, we show that continuous or transient application of flavonoids to the culture medium of embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications in the circadian clock amplitude, period, and phase.	Flavonoids	67-77	period circadian clock 2	Mus musculus	130-134
28012974-0	2017	The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels.	Flavonoids	13-23	caveolin 2	Homo sapiens	68-71
28012974-3	2017	In the last few years, flavonoids, widely distributed in the plant kingdom, have attracted the interest of many laboratories as an emerging class of fine ion, in particular Cav, channels modulators.	Flavonoids	23-33	caveolin 2	Homo sapiens	173-176
28012974-6	2017	Here we examine numerous studies aimed at analysing this feature of flavonoids, focusing on the mechanisms that promote their sometimes controversial activities at cardiovascular Cav channels.	Flavonoids	68-78	caveolin 2	Homo sapiens	179-182
28012974-7	2017	New methodological approaches, such as molecular modelling and docking to Cav1.2 channel alpha1c subunit, used to elucidate flavonoids intrinsic mechanism of action, are introduced.	Flavonoids	124-134	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	74-80
28152057-8	2017	In summary, among the tested flavonoids, polymethoxy flavones increased the amplitude, lengthened the period, and delayed the phase of the PER2::LUC circadian rhythm.	Flavonoids	29-39	period circadian clock 2	Mus musculus	139-143
28212288-7	2017	Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity.	Flavonoids	0-10	paraoxonase 1	Mus musculus	140-144
28152057-4	2017	In this study, we show that continuous or transient application of flavonoids to the culture medium of embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications in the circadian clock amplitude, period, and phase.	Flavonoids	67-77	period circadian clock 2	Mus musculus	148-152
28152057-5	2017	Transient application of some of the tested flavonoids to cultured cells induced a phase delay of the PER2::LUC rhythm at the down slope phase.	Flavonoids	44-54	period circadian clock 2	Mus musculus	102-106
27699481-2	2017	In this study, we propose a kinetic model for flavonoid production in tea cell culture based on the cell life cycle and expression of PAL, the gene encoding phenylalanine ammonia-lyase (PAL)-the key enzyme in flavonoid biosynthesis.	Flavonoids	46-55	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	134-137
28028694-0	2017	A new model of flavonoids affinity towards P-glycoprotein: genetic algorithm-support vector machine with features selected by a modified particle swarm optimization algorithm.	Flavonoids	15-25	ATP binding cassette subfamily B member 1	Homo sapiens	43-57
28028694-1	2017	Flavonoids exhibit a high affinity for the purified cytosolic NBD (C-terminal nucleotide-binding domain) of P-glycoprotein (P-gp).	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	108-122
28028694-1	2017	Flavonoids exhibit a high affinity for the purified cytosolic NBD (C-terminal nucleotide-binding domain) of P-glycoprotein (P-gp).	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
28028694-2	2017	To explore the affinity of flavonoids for P-gp, quantitative structure-activity relationship (QSAR) models were developed using support vector machines (SVMs).	Flavonoids	27-37	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
27699481-2	2017	In this study, we propose a kinetic model for flavonoid production in tea cell culture based on the cell life cycle and expression of PAL, the gene encoding phenylalanine ammonia-lyase (PAL)-the key enzyme in flavonoid biosynthesis.	Flavonoids	46-55	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	157-184
27699481-2	2017	In this study, we propose a kinetic model for flavonoid production in tea cell culture based on the cell life cycle and expression of PAL, the gene encoding phenylalanine ammonia-lyase (PAL)-the key enzyme in flavonoid biosynthesis.	Flavonoids	46-55	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	186-189
27699481-2	2017	In this study, we propose a kinetic model for flavonoid production in tea cell culture based on the cell life cycle and expression of PAL, the gene encoding phenylalanine ammonia-lyase (PAL)-the key enzyme in flavonoid biosynthesis.	Flavonoids	209-218	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	134-137
27699481-2	2017	In this study, we propose a kinetic model for flavonoid production in tea cell culture based on the cell life cycle and expression of PAL, the gene encoding phenylalanine ammonia-lyase (PAL)-the key enzyme in flavonoid biosynthesis.	Flavonoids	209-218	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	157-184
27699481-2	2017	In this study, we propose a kinetic model for flavonoid production in tea cell culture based on the cell life cycle and expression of PAL, the gene encoding phenylalanine ammonia-lyase (PAL)-the key enzyme in flavonoid biosynthesis.	Flavonoids	209-218	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	186-189
27699481-3	2017	The flavonoid production rate was considered to be related to the amount of active PAL.	Flavonoids	4-13	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	83-86
28049590-0	2017	Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain.	Flavonoids	24-34	pyruvate dehydrogenase kinase 1	Homo sapiens	71-106
28049590-4	2017	In this study, we established a novel method to study protein-lipid interactions and screened for flavonoid-derived antagonists of PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 (PDK1) pleckstrin homology (PH) domain.	Flavonoids	98-107	pyruvate dehydrogenase kinase 1	Homo sapiens	164-199
28049590-4	2017	In this study, we established a novel method to study protein-lipid interactions and screened for flavonoid-derived antagonists of PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 (PDK1) pleckstrin homology (PH) domain.	Flavonoids	98-107	pyruvate dehydrogenase kinase 1	Homo sapiens	201-205
28049590-5	2017	Using an enhanced green fluorescent protein (eGFP)-tagged PDK1 PH domain and 50% sucrose-loaded liposomes, the protein-lipid interaction could be efficiently evaluated using liposome pull-down assays coupled with fluorescence spectrophotometry, and a total of 32 flavonoids were screened as antagonists for PtdIns(3,4,5)P3 binding with the PDK1 PH domain.	Flavonoids	263-273	pyruvate dehydrogenase kinase 1	Homo sapiens	58-62
28503087-3	2017	In this comprehensive review article, the current knowledge about the anticancer activities of flavonoids as plant secondary polyphenolic metabolites in the most commonly used human established leukemia cell lines (HL-60, NB4, KG1a, U937, THP-1, K562, Jurkat, CCRF- CEM, MOLT-3, and MOLT-4) is compiled, revealing clear anti-proliferative, pro-apoptotic, cell cycle arresting, and differentiation inducing effects for certain compounds.	Flavonoids	95-105	GLI family zinc finger 2	Homo sapiens	239-244
28035396-2	2017	In the present study, we demonstrated the effect of luteolin, a flavonoid with antioxidant, anti-inflammatory and anticancer activities, on the expression and activation of TAM RTKs and the association with its cytotoxicity in non-small cell lung cancer (NSCLC) cells.	Flavonoids	64-73	Myeloproliferative syndrome, transient (transient abnormal myelopoiesis)	Homo sapiens	173-176
28035361-6	2017	An increase in the total apoptotic cells and G2/M cell cycle arrest with decreased protein expression of CDC25C, CDK1, cyclin B1 and p21 were observed in Hep3B cells treated with flavonoids of C. platymamma.	Flavonoids	179-189	cell division cycle 25C	Homo sapiens	105-111
28035361-6	2017	An increase in the total apoptotic cells and G2/M cell cycle arrest with decreased protein expression of CDC25C, CDK1, cyclin B1 and p21 were observed in Hep3B cells treated with flavonoids of C. platymamma.	Flavonoids	179-189	cyclin dependent kinase 1	Homo sapiens	113-117
28035361-6	2017	An increase in the total apoptotic cells and G2/M cell cycle arrest with decreased protein expression of CDC25C, CDK1, cyclin B1 and p21 were observed in Hep3B cells treated with flavonoids of C. platymamma.	Flavonoids	179-189	cyclin B1	Homo sapiens	119-128
28035361-6	2017	An increase in the total apoptotic cells and G2/M cell cycle arrest with decreased protein expression of CDC25C, CDK1, cyclin B1 and p21 were observed in Hep3B cells treated with flavonoids of C. platymamma.	Flavonoids	179-189	H3 histone pseudogene 16	Homo sapiens	133-136
27826992-4	2017	In this review article, the important contribution of dietary catechol-containing flavonoids to modification of the relationships between the COMT genotype and cancer risk is discussed.	Flavonoids	82-92	catechol-O-methyltransferase	Homo sapiens	142-146
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	Flavonoids	252-262	catechol-O-methyltransferase	Homo sapiens	193-197
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	Flavonoids	252-262	catechol-O-methyltransferase	Homo sapiens	307-311
27826992-6	2017	Such a many-featured functioning of the COMT and its complex regulation by several different genetic and environmental factors, including plant-based food ingredients, emphasizes the necessity to further stratify the association studies between the COMT genotype and tumor risk by consumption of catechol-containing dietary flavonoids.	Flavonoids	324-334	catechol-O-methyltransferase	Homo sapiens	40-44
27826992-6	2017	Such a many-featured functioning of the COMT and its complex regulation by several different genetic and environmental factors, including plant-based food ingredients, emphasizes the necessity to further stratify the association studies between the COMT genotype and tumor risk by consumption of catechol-containing dietary flavonoids.	Flavonoids	324-334	catechol-O-methyltransferase	Homo sapiens	249-253
27871793-0	2017	Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer"s disease.	Flavonoids	131-141	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80
27871793-1	2017	The current objective of the study is to identify inhibitory affinity potential of the certain commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) enzyme using in silico and in vitro studies.	Flavonoids	118-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179
27871793-1	2017	The current objective of the study is to identify inhibitory affinity potential of the certain commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) enzyme using in silico and in vitro studies.	Flavonoids	118-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
27871793-6	2017	In vitro results showed that all the selected flavonoids displayed excellent concentration-dependant inhibition of AChE.	Flavonoids	46-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
26942689-5	2017	Docking analyses of pharmacokinetically screened metabolites and their comparison with a known inhibitor (drug), namely zileuton revealed that only three alkaloids, six flavonoids and three terpenoids were found to dock successfully with 5-LOX with the flavonoid, velutin being the most potent inhibitor among all.	Flavonoids	169-179	lysyl oxidase	Homo sapiens	240-243
27794589-6	2017	We found that the flavonoid tilianin regulated MUC5AC expression and also inhibited Sp1 phosphorylation.	Flavonoids	18-27	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	47-53
27690380-0	2017	Flavonoids from Litsea japonica Inhibit AGEs Formation and Rat Lense Aldose Reductase In Vitro and Vessel Dilation in Zebrafish.	Flavonoids	0-10	aldo-keto reductase family 1 member B1	Rattus norvegicus	69-85
27690380-5	2017	In the rat lens aldose reductase assay, consistent with the inhibition of advanced glycation end products formation, the flavonoids (3, 4, 6-8, 11, and 12) exhibited considerable inhibition of rat lens aldose reductase activity, with IC50 values of 1.1-12.5 microM.	Flavonoids	121-131	aldo-keto reductase family 1 member B1	Rattus norvegicus	16-32
27690380-5	2017	In the rat lens aldose reductase assay, consistent with the inhibition of advanced glycation end products formation, the flavonoids (3, 4, 6-8, 11, and 12) exhibited considerable inhibition of rat lens aldose reductase activity, with IC50 values of 1.1-12.5 microM.	Flavonoids	121-131	aldo-keto reductase family 1 member B1	Rattus norvegicus	202-218
28067837-1	2017	Previously, we reported the role of synergy between two flavonoids-namely, chrysin and kaempferol-in inhibiting the secretion of a few major proinflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and nitric oxide (NO) from lipopolysaccharide (LPS)-induced RAW 264.7 cells.	Flavonoids	56-66	tumor necrosis factor	Mus musculus	175-202
27984000-0	2017	Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.	Flavonoids	0-9	ATP binding cassette subfamily C member 1	Homo sapiens	94-98
27984000-1	2017	MRP1 overexpression in multidrug-resistant cancer cells has been shown to be responsible for collateral sensitivity to some flavonoids that stimulate a huge MRP1-mediated GSH efflux.	Flavonoids	124-134	ATP binding cassette subfamily C member 1	Homo sapiens	0-4
27984000-1	2017	MRP1 overexpression in multidrug-resistant cancer cells has been shown to be responsible for collateral sensitivity to some flavonoids that stimulate a huge MRP1-mediated GSH efflux.	Flavonoids	124-134	ATP binding cassette subfamily C member 1	Homo sapiens	157-161
27984000-3	2017	We describe here that bivalent flavonoid dimers strikingly stimulate such MRP1-mediated GSH efflux and trigger a 50-100 fold more potent cell death than their corresponding monomers.	Flavonoids	31-40	ATP binding cassette subfamily C member 1	Homo sapiens	74-78
27984000-5	2017	The best flavonoid dimer, 4e, kills MRP1-overexpressing cells with a selective ratio higher than 1000 compared to control cells and an EC50 value of 0.1 muM, so far unequaled as a collateral sensitivity agent targeting ABC transporters.	Flavonoids	9-18	ATP binding cassette subfamily C member 1	Homo sapiens	36-40
27984000-5	2017	The best flavonoid dimer, 4e, kills MRP1-overexpressing cells with a selective ratio higher than 1000 compared to control cells and an EC50 value of 0.1 muM, so far unequaled as a collateral sensitivity agent targeting ABC transporters.	Flavonoids	9-18	latexin	Homo sapiens	153-156
27984000-6	2017	This result portends the flavonoid dimer 4e as a very promising compound to appraise in vivo the therapeutic potential of collateral sensitivity for eradication of MRP1-overexpressing chemoresistant cancer cells in tumors.	Flavonoids	25-34	ATP binding cassette subfamily C member 1	Homo sapiens	164-168
27852009-8	2017	To date, many epigenetically active natural substances (such as polyphenols and flavonoids) and synthetic compounds such as DNMT inhibitors or HDAC inhibitors are known.	Flavonoids	80-90	DNA methyltransferase 1	Homo sapiens	124-128
28098811-3	2017	However, as one of possible, it is well known that phytochemical flavonoids reduce oxidative stress via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation resulting in up-regulation of antioxidant genes and enzymes.	Flavonoids	65-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-147
28098811-3	2017	However, as one of possible, it is well known that phytochemical flavonoids reduce oxidative stress via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation resulting in up-regulation of antioxidant genes and enzymes.	Flavonoids	65-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-153
28072821-0	2017	Maysin and Its Flavonoid Derivative from Centipedegrass Attenuates Amyloid Plaques by Inducting Humoral Immune Response with Th2 Skewed Cytokine Response in the Tg (APPswe, PS1dE9) Alzheimer"s Mouse Model.	Flavonoids	15-24	heart and neural crest derivatives expressed 2	Mus musculus	125-128
28067837-1	2017	Previously, we reported the role of synergy between two flavonoids-namely, chrysin and kaempferol-in inhibiting the secretion of a few major proinflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), and nitric oxide (NO) from lipopolysaccharide (LPS)-induced RAW 264.7 cells.	Flavonoids	56-66	tumor necrosis factor	Mus musculus	204-213
28105033-0	2016	A Grapevine TTG2-Like WRKY Transcription Factor Is Involved in Regulating Vacuolar Transport and Flavonoid Biosynthesis.	Flavonoids	97-106	WRKY family transcription factor family protein	Arabidopsis thaliana	12-16
27766768-2	2017	Our data allow the elucidation of their structure-activity relationships, showing that glycosylation has a modest impact on flavonoid affinity for Abeta oligomers but, at the same time, increases both solubility and chemical stability, thus promoting their beneficial properties against Alzheimer"s disease (AD).	Flavonoids	124-133	amyloid beta precursor protein	Homo sapiens	147-152
27984083-1	2017	Many flavonoids are reported to be partial agonists of PPARgamma and exert antidiabetic effects with fewer side effects compared with full agonists.	Flavonoids	5-15	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	55-64
28427563-8	2017	However, modulation of P-glycoprotein, rather than antioxidant and anti-inflammatory effects, could be the major mechanism of polyphenolic compounds, including flavonoids.	Flavonoids	160-170	ATP binding cassette subfamily B member 1	Homo sapiens	23-37
28043125-8	2017	Our results confirm that flavonoids are avid inhibitors of BCRP, and flavones and flavonols appear to be important subclasses of flavonoids for this inhibition.	Flavonoids	25-35	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	59-63
27591048-5	2017	Actually, it was shown that this flavonoid may bind to the red blood cell membrane surface, which may improve the interaction between EGCG and AChE.	Flavonoids	33-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-147
29234372-0	2017	Hawthorn Leaf Flavonoids Protect against Diabetes-Induced Cardiomyopathy in Rats via PKC-alpha Signaling Pathway.	Flavonoids	14-24	protein kinase C, alpha	Rattus norvegicus	85-94
28231749-0	2017	Flavonoids and Tannins from Smilax china L. Rhizome Induce Apoptosis Via Mitochondrial Pathway and MDM2-p53 Signaling in Human Lung Adenocarcinoma Cells.	Flavonoids	0-10	MDM2 proto-oncogene	Homo sapiens	99-103
28231749-0	2017	Flavonoids and Tannins from Smilax china L. Rhizome Induce Apoptosis Via Mitochondrial Pathway and MDM2-p53 Signaling in Human Lung Adenocarcinoma Cells.	Flavonoids	0-10	tumor protein p53	Homo sapiens	104-107
28231749-6	2017	Cleaved-caspase-3 protein levels in A549 cells after treatment with total flavonoids or total tannins were increased in a dose-dependent manner, followed by the activation of caspase-8 and caspase-9, finally triggering to PARP cleavage.	Flavonoids	74-84	caspase 8	Homo sapiens	175-184
28231749-6	2017	Cleaved-caspase-3 protein levels in A549 cells after treatment with total flavonoids or total tannins were increased in a dose-dependent manner, followed by the activation of caspase-8 and caspase-9, finally triggering to PARP cleavage.	Flavonoids	74-84	caspase 9	Homo sapiens	189-198
28231749-6	2017	Cleaved-caspase-3 protein levels in A549 cells after treatment with total flavonoids or total tannins were increased in a dose-dependent manner, followed by the activation of caspase-8 and caspase-9, finally triggering to PARP cleavage.	Flavonoids	74-84	collagen type XI alpha 2 chain	Homo sapiens	222-226
28231749-7	2017	Furthermore, total flavonoids and total tannins increased the expression of Bax, decreased the expression of Bcl-2, and promoted cytochrome [Formula: see text] release.	Flavonoids	19-29	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79
28231749-7	2017	Furthermore, total flavonoids and total tannins increased the expression of Bax, decreased the expression of Bcl-2, and promoted cytochrome [Formula: see text] release.	Flavonoids	19-29	BCL2 apoptosis regulator	Homo sapiens	109-114
28231749-8	2017	Moreover, MDM2 and p-MDM2 proteins were decreased, while p53 and p-p53 proteins were increased, both in a dose-dependent manner, after A549 treatment with total flavonoids and total tannins.	Flavonoids	161-171	MDM2 proto-oncogene	Homo sapiens	10-14
28231749-8	2017	Moreover, MDM2 and p-MDM2 proteins were decreased, while p53 and p-p53 proteins were increased, both in a dose-dependent manner, after A549 treatment with total flavonoids and total tannins.	Flavonoids	161-171	MDM2 proto-oncogene	Homo sapiens	21-25
28231749-8	2017	Moreover, MDM2 and p-MDM2 proteins were decreased, while p53 and p-p53 proteins were increased, both in a dose-dependent manner, after A549 treatment with total flavonoids and total tannins.	Flavonoids	161-171	tumor protein p53	Homo sapiens	57-60
28231749-8	2017	Moreover, MDM2 and p-MDM2 proteins were decreased, while p53 and p-p53 proteins were increased, both in a dose-dependent manner, after A549 treatment with total flavonoids and total tannins.	Flavonoids	161-171	tumor protein p53	Homo sapiens	67-70
28231749-10	2017	Our results indicated that total flavonoids and total tannins from SCR exerted a remarkable effect in reducing A549 growth through their action on mitochondrial pathway and disruption of MDM2-p53 balance.	Flavonoids	33-43	MDM2 proto-oncogene	Homo sapiens	187-191
28231749-10	2017	Our results indicated that total flavonoids and total tannins from SCR exerted a remarkable effect in reducing A549 growth through their action on mitochondrial pathway and disruption of MDM2-p53 balance.	Flavonoids	33-43	tumor protein p53	Homo sapiens	192-195
27798765-0	2017	Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells.	Flavonoids	26-35	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	78-109
28154265-3	2017	Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid beta (Abeta) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs.	Flavonoids	17-27	amyloid beta precursor protein	Homo sapiens	74-86
28154265-3	2017	Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid beta (Abeta) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs.	Flavonoids	17-27	amyloid beta precursor protein	Homo sapiens	88-93
27856006-10	2017	Taken together, these data indicate the structural changes observed for the Abeta(25-40) and G37A peptides upon introduction of myricetin are localized around residue 32 and could arise from hydrophobic interactions between the peptide and the flavonoid or interference with the self-association of the peptide in this region.	Flavonoids	244-253	amyloid beta precursor protein	Homo sapiens	76-81
28073929-3	2017	We looked at carbon loss, known to occur in the heterologous flavonoid pathway in yeast, and identified an endogenous enzyme, the enoyl reductase Tsc13, which turned out to be responsible for the accumulation of phloretic acid via reduction of p-coumaroyl-CoA.	Flavonoids	61-70	trans-2-enoyl-CoA reductase (NADPH) TSC13	Saccharomyces cerevisiae S288C	146-151
28222028-9	2017	Human SULT1C4 sulfonated all the estrogenic compounds tested, including dietary flavonoids and environmental estrogens; however, the enzyme has a higher affinity for sulfonation of flavonoids.	Flavonoids	80-90	sulfotransferase family 1C member 4	Homo sapiens	6-13
28222028-9	2017	Human SULT1C4 sulfonated all the estrogenic compounds tested, including dietary flavonoids and environmental estrogens; however, the enzyme has a higher affinity for sulfonation of flavonoids.	Flavonoids	181-191	sulfotransferase family 1C member 4	Homo sapiens	6-13
28867739-3	2017	Various flavonoids in vegetables, such as kaempferol and quercetin, possess inhibitory effects, and some vegetable and fruit juices have also been found to inhibit CYP3A4 activity.	Flavonoids	8-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	164-170
29318154-7	2017	Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property.	Flavonoids	114-124	complement C4A (Rodgers blood group)	Homo sapiens	36-39
26592500-1	2017	Deguelin, a naturally occurring rotenoid of the flavonoid family, is known to be an Akt inhibitor, to have chemopreventive activities and anti-tumor effect on several cancers.	Flavonoids	48-57	AKT serine/threonine kinase 1	Homo sapiens	84-87
28458712-20	2017	The flavonoids might reduce the production of inflammatory cytokines through downregulation of NF-kappaB expression in inflammatory pathway and regulate the IRS-1-PI3-K-PKB/Akt insulin pathway and thereby increased the GLUT4 expression.	Flavonoids	4-14	insulin receptor substrate 1	Rattus norvegicus	157-162
28458712-20	2017	The flavonoids might reduce the production of inflammatory cytokines through downregulation of NF-kappaB expression in inflammatory pathway and regulate the IRS-1-PI3-K-PKB/Akt insulin pathway and thereby increased the GLUT4 expression.	Flavonoids	4-14	solute carrier family 2 member 4	Rattus norvegicus	219-224
29129989-6	2017	The flavonoids isolated from the propolis also showed markedly inhibited platelet aggregation induced by collagen, ADP, and TRAP, respectively.	Flavonoids	4-14	TRAP	Homo sapiens	124-128
29445755-1	2017	Objective: This study aimed to explore the immunoregulatory effect of flavonoids of blueberry (Vaccinium corymbosum L.) leaves (FBL).	Flavonoids	70-80	fibrillarin	Mus musculus	128-131
28250730-6	2017	Recently, the flavonoid 7,8-dihydroxyflavone (7,8-DHF), a small TrkB agonist that mimics BDNF function, has shown similar effects as BDNF in promoting neuronal survival and regeneration following TBI.	Flavonoids	14-23	neurotrophic receptor tyrosine kinase 2	Homo sapiens	64-68
27778136-8	2017	The increased amount of nuclear SREBP-2 in cells was attenuated by the flavonoid as shown by immunocytochemical imaging.	Flavonoids	71-80	sterol regulatory element binding transcription factor 2	Homo sapiens	32-39
28373746-4	2017	Many papers reported that anthocyanins, a group of compounds belonging to flavonoids, possess anti-inflammatory effects and modulate NF-kappaB activity.	Flavonoids	74-84	nuclear factor kappa B subunit 1	Homo sapiens	133-142
28250730-6	2017	Recently, the flavonoid 7,8-dihydroxyflavone (7,8-DHF), a small TrkB agonist that mimics BDNF function, has shown similar effects as BDNF in promoting neuronal survival and regeneration following TBI.	Flavonoids	14-23	brain derived neurotrophic factor	Homo sapiens	89-93
29230268-5	2017	The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin.	Flavonoids	173-185	matrix metallopeptidase 2	Homo sapiens	77-82
28761622-0	2017	Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARgamma.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
28761622-0	2017	Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARgamma.	Flavonoids	0-10	peroxisome proliferator activated receptor gamma	Homo sapiens	77-86
28761622-6	2017	Most of the tested flavonoids, but not the antioxidant vitamins, stimulated Nrf2-, FoxO-, and PPARgamma-dependent promoter activities.	Flavonoids	19-29	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
28761622-6	2017	Most of the tested flavonoids, but not the antioxidant vitamins, stimulated Nrf2-, FoxO-, and PPARgamma-dependent promoter activities.	Flavonoids	19-29	peroxisome proliferator activated receptor gamma	Homo sapiens	94-103
28761622-7	2017	Flavonoids activating Nrf2 also tended to induce a FoxO and PPARgamma response.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
28761622-7	2017	Flavonoids activating Nrf2 also tended to induce a FoxO and PPARgamma response.	Flavonoids	0-10	peroxisome proliferator activated receptor gamma	Homo sapiens	60-69
28698766-3	2017	The present study aimed to investigate the efficacy of an apple flavonoid fraction (AF4) against various carcinogen-induced toxicity in normal human bronchial epithelial cells and its mechanism of DNA damage response and repair processes.	Flavonoids	64-73	AF4/FMR2 family member 1	Homo sapiens	84-87
29138679-4	2017	Flavonoids, which exist in copious amounts in nature, possess a wide array of functions; their supplementation during pregnancy activates Nrf2 signaling pathway which encounters pregnancy disorders.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	138-142
29362666-6	2017	VCAF had high phenolic and flavonoid contents and strong antioxidant activity.	Flavonoids	27-36	host cell factor C1	Homo sapiens	0-4
29230268-5	2017	The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin.	Flavonoids	173-185	matrix metallopeptidase 9	Homo sapiens	87-92
27793764-2	2016	Previous studies shown that TNF-alpha plays a central role in intestinal inflammation of IBDs and supported beneficial effects of flavonoids against chronic inflammatory diseases.	Flavonoids	130-140	tumor necrosis factor	Homo sapiens	28-37
27842477-0	2017	Cytotoxicity and Anti-inflammatory Activity of Flavonoid Derivatives Targeting NF-kappaB.	Flavonoids	47-56	nuclear factor kappa B subunit 1	Homo sapiens	79-88
29348759-0	2017	The Flavonoid Glabridin Induces OCT4 to Enhance Osteogenetic Potential in Mesenchymal Stem Cells.	Flavonoids	4-13	POU class 5 homeobox 1	Homo sapiens	32-36
27777014-0	2016	Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.	Flavonoids	14-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-59
27777014-0	2016	Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.	Flavonoids	14-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Flavonoids	12-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Flavonoids	12-21	heme oxygenase 1	Mus musculus	149-165
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Flavonoids	12-21	NAD(P)H dehydrogenase, quinone 1	Mus musculus	177-209
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Flavonoids	12-21	NAD(P)H dehydrogenase, quinone 1	Mus musculus	211-215
27777014-2	2016	In this study, a novel semisynthetic flavonoid 7-O-galloylquercetin (or quercetin-7-gallate, 3) was prepared by direct galloylation of quercetin, and its effect on the Nrf2 pathway was examined.	Flavonoids	37-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	168-172
28004841-0	2016	The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway.	Flavonoids	11-20	activating transcription factor 3	Mus musculus	95-99
28004841-0	2016	The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway.	Flavonoids	11-20	toll-like receptor 4	Mus musculus	137-141
28174680-5	2017	Complexes of the AtGSTF2 dimer were obtained with indole-3-aldehyde, camalexin, the flavonoid quercetrin and its non-rhamnosylated analogue quercetin, at resolutions of 2.00, 2.77, 2.25 and 2.38 A respectively.	Flavonoids	84-93	glutathione S-transferase PHI 2	Arabidopsis thaliana	17-24
27760293-3	2016	In this study, "native" mass spectrometry (MS) was used to study the noncovalent interactions between SOD1 and flavonoid compounds.	Flavonoids	111-120	superoxide dismutase 1	Homo sapiens	102-106
27760293-5	2016	ESI-MS was used to detect the SOD1-flavonoid complexes and compare their relative binding strengths.	Flavonoids	35-44	superoxide dismutase 1	Homo sapiens	30-34
27760293-7	2016	Molecular docking together with molecular dynamics simulations and MM/PBSA methods were applied to gain insights into the binding modes and free energies of SOD1-flavonoid complexes at the molecule level.	Flavonoids	162-171	superoxide dismutase 1	Homo sapiens	157-161
27760293-8	2016	Among all the flavonoids investigated, flavonoid glycosides preferentially bind to SOD1 than their aglycone counterparts.	Flavonoids	14-24	superoxide dismutase 1	Homo sapiens	83-87
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Flavonoids	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212
27523747-0	2016	Ginkgoghrelins, unique acylated flavonoid diglycosides in Folium Ginkgo, stimulate growth hormone secretion via activation of the ghrelin receptor.	Flavonoids	32-41	ghrelin and obestatin prepropeptide	Rattus norvegicus	6-13
28101184-3	2016	Flavonoid luteolin has been shown to markedly inhibit Tyr705 activation/phosphorylation of STAT3 and exert anti-inflammatory effects in multiple sclerosis.	Flavonoids	0-9	signal transducer and activator of transcription 3	Mus musculus	91-96
27909560-3	2016	Here, we show that the flavonoid quercetin reduces obesity-induced hepatic inflammation by inducing HO-1, which promotes hepatic macrophage polarization in favor of the M2 phenotype.	Flavonoids	23-32	heme oxygenase 1	Mus musculus	100-104
27842297-0	2016	RNAi-mediated suppression of dihydroflavonol 4-reductase in tobacco allows fine-tuning of flower color and flux through the flavonoid biosynthetic pathway.	Flavonoids	124-133	dihydroflavonol-4-reductase	Nicotiana tabacum	29-56
27842297-1	2016	To examine flux regulation in the flavonoid pathway of tobacco flowers, we suppressed two genes for dihydroflavonol 4-reductase (NtDFR 1 and 2) by RNA interference (Ri)-mediated post transcriptional gene silencing in pink-flowered tobacco.	Flavonoids	34-43	dihydroflavonol-4-reductase	Nicotiana tabacum	100-127
27842297-1	2016	To examine flux regulation in the flavonoid pathway of tobacco flowers, we suppressed two genes for dihydroflavonol 4-reductase (NtDFR 1 and 2) by RNA interference (Ri)-mediated post transcriptional gene silencing in pink-flowered tobacco.	Flavonoids	34-43	dihydroflavonol-4-reductase	Nicotiana tabacum	129-142
27842297-9	2016	This finding suggests that suppression of DFR can increase the total levels of flavonoids due to (dihydro) flavonol biosynthesis.	Flavonoids	79-89	dihydroflavonol-4-reductase	Nicotiana tabacum	42-45
28042498-5	2016	Furthermore, alpinumisoflavone, a naturally occurring flavonoid, could inhibit tumor growth of ESCC by targeting miR-370/PIM1 signaling.	Flavonoids	54-63	microRNA 370	Homo sapiens	113-120
27165851-10	2016	In addition few small molecular inhibitors such as flavonoids have also been developed which are capable of binding with high affinity to IL-4Ralpha and, therefore, can be very effective in blocking IL-4-mediated responses.	Flavonoids	51-61	interleukin 4 receptor	Homo sapiens	138-148
27842297-10	2016	Our observations that higher suppression of DFR had a greater influence on the expression of flavonoid biosynthetic genes demonstrates the key role of DFR in the pathway and allows selection among DFR-Ri lines for plants with specific gene expression profiles to fine-tune flux through the pathway.	Flavonoids	93-102	dihydroflavonol-4-reductase	Nicotiana tabacum	44-47
27842297-10	2016	Our observations that higher suppression of DFR had a greater influence on the expression of flavonoid biosynthetic genes demonstrates the key role of DFR in the pathway and allows selection among DFR-Ri lines for plants with specific gene expression profiles to fine-tune flux through the pathway.	Flavonoids	93-102	dihydroflavonol-4-reductase	Nicotiana tabacum	151-154
27842297-10	2016	Our observations that higher suppression of DFR had a greater influence on the expression of flavonoid biosynthetic genes demonstrates the key role of DFR in the pathway and allows selection among DFR-Ri lines for plants with specific gene expression profiles to fine-tune flux through the pathway.	Flavonoids	93-102	dihydroflavonol-4-reductase	Nicotiana tabacum	151-154
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Flavonoids	46-56	tumor necrosis factor	Homo sapiens	283-292
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Flavonoids	46-56	interleukin 1 beta	Homo sapiens	294-302
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Flavonoids	46-56	interleukin 6	Homo sapiens	304-308
27816506-2	2016	The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-kappaB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-alpha, IL-1beta, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes.	Flavonoids	46-56	C-C motif chemokine ligand 5	Homo sapiens	310-314
28713203-4	2016	We herein developed a series of amide-functionalized flavonoids probes, 1-3, for recognition of human serum albumin.	Flavonoids	53-63	albumin	Homo sapiens	102-115
27916850-1	2016	In this study, in silico approaches, including multiple QSAR modeling, structural similarity analysis, and molecular docking, were applied to develop QSAR classification models as a fast screening tool for identifying highly-potent ABCA1 up-regulators targeting LXRbeta based on a series of new flavonoids.	Flavonoids	295-305	ATP binding cassette subfamily A member 1	Homo sapiens	232-237
27916850-1	2016	In this study, in silico approaches, including multiple QSAR modeling, structural similarity analysis, and molecular docking, were applied to develop QSAR classification models as a fast screening tool for identifying highly-potent ABCA1 up-regulators targeting LXRbeta based on a series of new flavonoids.	Flavonoids	295-305	nuclear receptor subfamily 1 group H member 2	Homo sapiens	262-269
28480406-2	2017	MATERIALS AND METHODS: The purpose of this study was to investigate the mechanism by which citrus flavonoids, naringenin regulate the LDL receptor (LDLr) gene in human liver using the human hepatoma cell line, HepG2 as a model.	Flavonoids	98-108	low density lipoprotein receptor	Homo sapiens	134-146
27019979-0	2016	Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts.	Flavonoids	0-10	acetylcholinesterase	Rattus norvegicus	36-56
27019979-2	2016	Here, we aimed to test if flavonoid could induce a cholinergic enzyme, acetylcholinesterase (AChE), as well as bone differentiation.	Flavonoids	26-35	acetylcholinesterase	Rattus norvegicus	71-91
27019979-2	2016	Here, we aimed to test if flavonoid could induce a cholinergic enzyme, acetylcholinesterase (AChE), as well as bone differentiation.	Flavonoids	26-35	acetylcholinesterase	Rattus norvegicus	93-97
27019979-3	2016	In cultured rat osteoblasts, twenty flavonoids, deriving from Chinese herbs and having known induction of alkaline phosphatase (ALP1) expression, were tested for its induction activity on AChE expression.	Flavonoids	36-46	alkaline phosphatase, intestinal	Rattus norvegicus	128-132
27019979-3	2016	In cultured rat osteoblasts, twenty flavonoids, deriving from Chinese herbs and having known induction of alkaline phosphatase (ALP1) expression, were tested for its induction activity on AChE expression.	Flavonoids	36-46	acetylcholinesterase	Rattus norvegicus	188-192
27019979-4	2016	Eleven flavonoids showed the induction, and five of them had robust activation of AChE expression, including baicalin, calycosin, genistin, hyperin and pratensein: the induction of AChE included the levels of mRNA, protein and enzymatic activity.	Flavonoids	7-17	acetylcholinesterase	Rattus norvegicus	181-185
27019979-5	2016	Moreover, the flavonoid-induced AChE expression in cultured osteoblast was in proline-rich membrane anchor (PRiMA)-linked tetrameric globular form (G4) only.	Flavonoids	14-23	acetylcholinesterase	Rattus norvegicus	32-36
27019979-5	2016	Moreover, the flavonoid-induced AChE expression in cultured osteoblast was in proline-rich membrane anchor (PRiMA)-linked tetrameric globular form (G4) only.	Flavonoids	14-23	proline rich membrane anchor 1	Rattus norvegicus	108-113
27019979-6	2016	In parallel, the expression of PRiMA was also induced by the application of flavonoids.	Flavonoids	76-86	proline rich membrane anchor 1	Rattus norvegicus	31-36
27019979-7	2016	The flavonoid-induced AChE in the cultures was not affected by estrogen receptor blocker, ICI 182,780.	Flavonoids	4-13	acetylcholinesterase	Rattus norvegicus	22-26
28480406-2	2017	MATERIALS AND METHODS: The purpose of this study was to investigate the mechanism by which citrus flavonoids, naringenin regulate the LDL receptor (LDLr) gene in human liver using the human hepatoma cell line, HepG2 as a model.	Flavonoids	98-108	low density lipoprotein receptor	Homo sapiens	148-152
27663735-10	2016	NT-stimulated responses are inhibited by the flavonoid methoxyluteolin (0.1-1 muM).	Flavonoids	45-54	latexin	Homo sapiens	78-81
27664008-5	2016	We found that dietary flavonoids could inhibit Chk1 phosphorylation and decrease clonogenic cell growth once breast cancer cells receive ultraviolet irradiation, cisplatin, or etoposide treatment.	Flavonoids	22-32	checkpoint kinase 1	Homo sapiens	47-51
27664008-6	2016	Since the ATR-Chk1 pathway mainly involves response to DNA replication stress, we propose that flavonoid derivatives reduce the side effect of chemotherapy by improving the sensitivity of cycling cells.	Flavonoids	95-104	ATR serine/threonine kinase	Homo sapiens	10-13
27664008-6	2016	Since the ATR-Chk1 pathway mainly involves response to DNA replication stress, we propose that flavonoid derivatives reduce the side effect of chemotherapy by improving the sensitivity of cycling cells.	Flavonoids	95-104	checkpoint kinase 1	Homo sapiens	14-18
27853354-0	2016	Development of novel HER2 inhibitors against gastric cancer derived from flavonoid source of Syzygium alternifolium through molecular dynamics and pharmacophore-based screening.	Flavonoids	73-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-25
27629412-6	2016	Baicalin, a herb-derived flavonoid compound, inhibited VSMC migration via upregulation of SM22alpha expression in vitro and in vivo.	Flavonoids	25-34	transgelin	Homo sapiens	90-99
27598863-4	2016	However, the flavonoid concentrations over 50ppm were found to be toxic to the THP-1 monocytes.	Flavonoids	13-22	GLI family zinc finger 2	Homo sapiens	79-84
27046632-2	2016	A transcription factor complex consisting of TT2, TT8 and TTG1 controls expression of PA biosynthetic genes, just as similar TTG1-dependent complexes have been shown to control flavonoid pigment pathway gene expression in general.	Flavonoids	177-186	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	58-62
27046632-2	2016	A transcription factor complex consisting of TT2, TT8 and TTG1 controls expression of PA biosynthetic genes, just as similar TTG1-dependent complexes have been shown to control flavonoid pigment pathway gene expression in general.	Flavonoids	177-186	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	125-129
27046632-4	2016	TTG2 mutants lack the pigmentation found in wild-type seeds, but produce other flavonoid compounds, such as anthocyanins in the shoot, suggesting that TTG2 regulates genes in the PA biosynthetic branch of the flavonoid pathway.	Flavonoids	79-88	WRKY family transcription factor family protein	Arabidopsis thaliana	0-4
27046632-4	2016	TTG2 mutants lack the pigmentation found in wild-type seeds, but produce other flavonoid compounds, such as anthocyanins in the shoot, suggesting that TTG2 regulates genes in the PA biosynthetic branch of the flavonoid pathway.	Flavonoids	79-88	WRKY family transcription factor family protein	Arabidopsis thaliana	151-155
27046632-4	2016	TTG2 mutants lack the pigmentation found in wild-type seeds, but produce other flavonoid compounds, such as anthocyanins in the shoot, suggesting that TTG2 regulates genes in the PA biosynthetic branch of the flavonoid pathway.	Flavonoids	209-218	WRKY family transcription factor family protein	Arabidopsis thaliana	0-4
27046632-4	2016	TTG2 mutants lack the pigmentation found in wild-type seeds, but produce other flavonoid compounds, such as anthocyanins in the shoot, suggesting that TTG2 regulates genes in the PA biosynthetic branch of the flavonoid pathway.	Flavonoids	209-218	WRKY family transcription factor family protein	Arabidopsis thaliana	151-155
27046632-9	2016	The observation that TTG1 interacts with TTG2, a WRKY type transcription factor, proposes the existence of a novel TTG1-containing complex, and an addendum to the existing paradigm of flavonoid pathway regulation.	Flavonoids	184-193	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	21-25
27046632-9	2016	The observation that TTG1 interacts with TTG2, a WRKY type transcription factor, proposes the existence of a novel TTG1-containing complex, and an addendum to the existing paradigm of flavonoid pathway regulation.	Flavonoids	184-193	WRKY family transcription factor family protein	Arabidopsis thaliana	41-45
27046632-9	2016	The observation that TTG1 interacts with TTG2, a WRKY type transcription factor, proposes the existence of a novel TTG1-containing complex, and an addendum to the existing paradigm of flavonoid pathway regulation.	Flavonoids	184-193	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	115-119
27046632-2	2016	A transcription factor complex consisting of TT2, TT8 and TTG1 controls expression of PA biosynthetic genes, just as similar TTG1-dependent complexes have been shown to control flavonoid pigment pathway gene expression in general.	Flavonoids	177-186	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	45-48
27046632-2	2016	A transcription factor complex consisting of TT2, TT8 and TTG1 controls expression of PA biosynthetic genes, just as similar TTG1-dependent complexes have been shown to control flavonoid pigment pathway gene expression in general.	Flavonoids	177-186	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	50-53
27598863-5	2016	Therefore, 10, 20 and 50ppm of flavonoid concentrations were tested for their anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated THP-1 monocytes.	Flavonoids	31-40	GLI family zinc finger 2	Homo sapiens	144-149
27598863-6	2016	Expression of inflammatory genes, IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha was found to be sequentially decreased when flavonoid concentration increased.	Flavonoids	120-129	interleukin 6	Homo sapiens	44-48
27770720-3	2016	Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2.	Flavonoids	14-24	nitric oxide synthase 2	Homo sapiens	237-241
27770720-4	2016	Their inhibitory effects on LPS-induced inflammatory responses correlated with the intensities of these flavonoids to suppress the LPS-induced activation of nuclear factor kappaB (NF-kappaB), an essential transcription factor for the mRNA expression of iNOS, TNFalpha, and CCL2.	Flavonoids	104-114	nuclear factor kappa B subunit 1	Homo sapiens	180-189
27598863-6	2016	Expression of inflammatory genes, IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha was found to be sequentially decreased when flavonoid concentration increased.	Flavonoids	120-129	interleukin 10	Homo sapiens	56-61
27770720-4	2016	Their inhibitory effects on LPS-induced inflammatory responses correlated with the intensities of these flavonoids to suppress the LPS-induced activation of nuclear factor kappaB (NF-kappaB), an essential transcription factor for the mRNA expression of iNOS, TNFalpha, and CCL2.	Flavonoids	104-114	nitric oxide synthase 2	Homo sapiens	253-257
27770720-3	2016	Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2.	Flavonoids	14-24	tumor necrosis factor	Homo sapiens	282-290
27770720-3	2016	Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2.	Flavonoids	14-24	C-C motif chemokine ligand 2	Homo sapiens	295-299
27770720-4	2016	Their inhibitory effects on LPS-induced inflammatory responses correlated with the intensities of these flavonoids to suppress the LPS-induced activation of nuclear factor kappaB (NF-kappaB), an essential transcription factor for the mRNA expression of iNOS, TNFalpha, and CCL2.	Flavonoids	104-114	tumor necrosis factor	Homo sapiens	259-267
27598863-6	2016	Expression of inflammatory genes, IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha was found to be sequentially decreased when flavonoid concentration increased.	Flavonoids	120-129	tumor necrosis factor	Homo sapiens	66-75
27770720-4	2016	Their inhibitory effects on LPS-induced inflammatory responses correlated with the intensities of these flavonoids to suppress the LPS-induced activation of nuclear factor kappaB (NF-kappaB), an essential transcription factor for the mRNA expression of iNOS, TNFalpha, and CCL2.	Flavonoids	104-114	C-C motif chemokine ligand 2	Homo sapiens	273-277
26758384-6	2016	Flavonoids 7, 8, 9 and the ethanolic extract showed the best results, with IC50 values of 20.94 muM, 44.20 muM, 30.01 muM and 58.82 mug/mL, respectively.	Flavonoids	0-10	latexin	Homo sapiens	96-99
27770720-5	2016	Among these flavonoids, 3",4"-dihydroxy-4-methoxydalbergione and 4-methoxydalbergion markedly inhibited the LPS-induced activation of IKK, thereby abrogating the degradation of IkappaBalpha and nuclear localization of NF-kappaB.	Flavonoids	12-22	NFKB inhibitor alpha	Homo sapiens	177-189
27770720-5	2016	Among these flavonoids, 3",4"-dihydroxy-4-methoxydalbergione and 4-methoxydalbergion markedly inhibited the LPS-induced activation of IKK, thereby abrogating the degradation of IkappaBalpha and nuclear localization of NF-kappaB.	Flavonoids	12-22	nuclear factor kappa B subunit 1	Homo sapiens	218-227
27770720-7	2016	The results of the present study revealed that these five kinds of flavonoids are the components of Nepalese propolis that exhibit anti-inflammatory activities with a different regulatory mechanism for the activation of NF-kappaB.	Flavonoids	67-77	nuclear factor kappa B subunit 1	Homo sapiens	220-229
26758384-6	2016	Flavonoids 7, 8, 9 and the ethanolic extract showed the best results, with IC50 values of 20.94 muM, 44.20 muM, 30.01 muM and 58.82 mug/mL, respectively.	Flavonoids	0-10	latexin	Homo sapiens	107-110
26758384-6	2016	Flavonoids 7, 8, 9 and the ethanolic extract showed the best results, with IC50 values of 20.94 muM, 44.20 muM, 30.01 muM and 58.82 mug/mL, respectively.	Flavonoids	0-10	latexin	Homo sapiens	107-110
28035345-0	2016	High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials.	Flavonoids	5-14	brain derived neurotrophic factor	Homo sapiens	80-113
27562381-9	2016	However, flavonoid biosynthesis genes were slightly down-regulated in the pap1-D/fls1ko seedlings as compared to their expression in pap1-D seedlings.	Flavonoids	9-18	production of anthocyanin pigment 1	Arabidopsis thaliana	74-78
27562381-9	2016	However, flavonoid biosynthesis genes were slightly down-regulated in the pap1-D/fls1ko seedlings as compared to their expression in pap1-D seedlings.	Flavonoids	9-18	production of anthocyanin pigment 1	Arabidopsis thaliana	133-137
27754693-3	2016	Further bioassay-guided fractionation led to the isolation of a flavonoid, acacetin, as the most prominent MAO inhibitory constituent, with IC50 values of 121 and 49 nM for MAO-A and -B, respectively.	Flavonoids	64-73	monoamine oxidase A	Homo sapiens	173-185
28035345-3	2016	OBJECTIVE: To investigate the link between changes in serum brain-derived neurotrophic factor (BDNF) and changes in human cognitive performance following flavonoid intake.	Flavonoids	154-163	brain derived neurotrophic factor	Homo sapiens	60-93
28035345-3	2016	OBJECTIVE: To investigate the link between changes in serum brain-derived neurotrophic factor (BDNF) and changes in human cognitive performance following flavonoid intake.	Flavonoids	154-163	brain derived neurotrophic factor	Homo sapiens	95-99
28035345-11	2016	In addition, following intervention for 18 weeks, high-flavonoid, but not low-flavonoid, fruit and vegetable intake induced significant improvements in cognitive performance and increases in serum BDNF levels (p = &lt;0.001).	Flavonoids	55-64	brain derived neurotrophic factor	Homo sapiens	197-201
28035345-13	2016	CONCLUSION: Increases in global cognition induced by high flavonoid fruit and vegetables, and cocoa flavanols were paralleled by concurrent changes in serum BDNF levels, suggesting a role for BDNF in flavonoid-induced cognitive improvements.	Flavonoids	200-209	brain derived neurotrophic factor	Homo sapiens	157-161
28035345-13	2016	CONCLUSION: Increases in global cognition induced by high flavonoid fruit and vegetables, and cocoa flavanols were paralleled by concurrent changes in serum BDNF levels, suggesting a role for BDNF in flavonoid-induced cognitive improvements.	Flavonoids	200-209	brain derived neurotrophic factor	Homo sapiens	192-196
27522262-0	2016	Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).	Flavonoids	29-38	catechol-O-methyltransferase	Homo sapiens	140-168
27725131-1	2016	Naturally-occurring bioactive flavonoids such as diosmin significantly reduces amyloid beta (Abeta) associated pathology in Alzheimer"s disease (AD) mouse models.	Flavonoids	30-40	amyloid beta (A4) precursor protein	Mus musculus	93-98
27551833-3	2016	Some natural and synthetic flavonoids and naphthoflavonoids have been extensively documented to exert pronounced influence in the modulation of CYP1s, including functioning as inhibitors, substrates, and aryl hydrocarbon receptor (AhR) ligands.	Flavonoids	27-37	aryl hydrocarbon receptor	Homo sapiens	204-229
27551833-3	2016	Some natural and synthetic flavonoids and naphthoflavonoids have been extensively documented to exert pronounced influence in the modulation of CYP1s, including functioning as inhibitors, substrates, and aryl hydrocarbon receptor (AhR) ligands.	Flavonoids	27-37	aryl hydrocarbon receptor	Homo sapiens	231-234
27551833-5	2016	This review summarizes the structural features responsible for the CYP1 inhibitory effects of the reported flavonoids and naphthoflavonoids.	Flavonoids	107-117	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-71
27522262-0	2016	Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).	Flavonoids	29-38	catechol-O-methyltransferase	Homo sapiens	170-174
27569589-0	2016	The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-kappaB signaling.	Flavonoids	4-13	CD44 molecule (Indian blood group)	Homo sapiens	47-51
27591790-4	2016	In the present study, the inhibitory activity of a plant flavonoid, hibifolin on ADA is investigated using enzyme kinetic assay and isothermal titration calorimetry.	Flavonoids	57-66	adenosine deaminase	Homo sapiens	81-84
27569589-0	2016	The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-kappaB signaling.	Flavonoids	4-13	AKT serine/threonine kinase 1	Homo sapiens	101-104
27569589-0	2016	The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-kappaB signaling.	Flavonoids	4-13	nuclear factor kappa B subunit 1	Homo sapiens	105-114
27307131-9	2016	Flavonoids are unique antioxidants that exert their beneficial effects through inhibition of nuclear factor kappaB, thereby attenuating release of inflammatory cytokines, which are triggers of insulin resistance.	Flavonoids	0-10	insulin	Homo sapiens	193-200
27307131-10	2016	Finally, flavonoids have shown to increase adiponectin, improve insulin sensitivity and glucose tolerance, correct dyslipidemia, and reduce blood pressure in patients with NAFLD.	Flavonoids	9-19	adiponectin, C1Q and collagen domain containing	Homo sapiens	43-54
27307131-10	2016	Finally, flavonoids have shown to increase adiponectin, improve insulin sensitivity and glucose tolerance, correct dyslipidemia, and reduce blood pressure in patients with NAFLD.	Flavonoids	9-19	insulin	Homo sapiens	64-71
27669565-0	2016	Suppression of Very Early Stage Of Adipogenesis by Baicalein, a Plant-Derived Flavonoid through Reduced Akt-C/EBPalpha-GLUT4 Signaling-Mediated Glucose Uptake in 3T3-L1 Adipocytes.	Flavonoids	78-87	thymoma viral proto-oncogene 1	Mus musculus	104-107
27658445-7	2016	The accumulation of flavonoids in the activation tagging mutant line pap1-D improved, while reduced flavonoid content in different knock-out mutants impaired leaf freezing tolerance.	Flavonoids	20-30	phosphatidic acid phosphatase 1	Arabidopsis thaliana	69-73
27658445-7	2016	The accumulation of flavonoids in the activation tagging mutant line pap1-D improved, while reduced flavonoid content in different knock-out mutants impaired leaf freezing tolerance.	Flavonoids	20-29	phosphatidic acid phosphatase 1	Arabidopsis thaliana	69-73
27652191-0	2016	Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs.	Flavonoids	8-18	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
27652191-3	2016	In this study, we have evaluated the inhibitory effects of natural bioflavonoids (quercetin and silymarin) on P-gp by using digoxin and quinidine as model P-gp model substrate drugs.	Flavonoids	67-80	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
27573346-3	2016	However, the molecular mechanism underlying the anticancer properties of flavonoids isolated from C. platymamma (FCP) remains to be elucidated.	Flavonoids	73-83	FCP1	Homo sapiens	113-116
27669565-0	2016	Suppression of Very Early Stage Of Adipogenesis by Baicalein, a Plant-Derived Flavonoid through Reduced Akt-C/EBPalpha-GLUT4 Signaling-Mediated Glucose Uptake in 3T3-L1 Adipocytes.	Flavonoids	78-87	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	108-118
27669565-0	2016	Suppression of Very Early Stage Of Adipogenesis by Baicalein, a Plant-Derived Flavonoid through Reduced Akt-C/EBPalpha-GLUT4 Signaling-Mediated Glucose Uptake in 3T3-L1 Adipocytes.	Flavonoids	78-87	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	119-124
27340105-1	2016	The total flavonoids from Persimmon leaves (PLF), extracted from the leaves of Diospyros kaki L. Dispryosl and Ebenaceae, is reported to possess many beneficial health effects.	Flavonoids	10-20	periostin	Rattus norvegicus	44-47
27489195-3	2016	In the present study, the cytotoxic profiles of natural flavonoids were described in two human CLL cell lines, HG-3 and EHEB, indicating the flavone luteolin as the most potent flavonoid with half-maximal inhibitory constants (IC50) of 37 muM and 26 muM, respectively.	Flavonoids	56-66	latexin	Homo sapiens	239-242
27489195-3	2016	In the present study, the cytotoxic profiles of natural flavonoids were described in two human CLL cell lines, HG-3 and EHEB, indicating the flavone luteolin as the most potent flavonoid with half-maximal inhibitory constants (IC50) of 37 muM and 26 muM, respectively.	Flavonoids	56-66	latexin	Homo sapiens	250-253
27489195-3	2016	In the present study, the cytotoxic profiles of natural flavonoids were described in two human CLL cell lines, HG-3 and EHEB, indicating the flavone luteolin as the most potent flavonoid with half-maximal inhibitory constants (IC50) of 37 muM and 26 muM, respectively.	Flavonoids	56-65	latexin	Homo sapiens	239-242
27489195-3	2016	In the present study, the cytotoxic profiles of natural flavonoids were described in two human CLL cell lines, HG-3 and EHEB, indicating the flavone luteolin as the most potent flavonoid with half-maximal inhibitory constants (IC50) of 37 muM and 26 muM, respectively.	Flavonoids	56-65	latexin	Homo sapiens	250-253
27494895-0	2016	Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation.	Flavonoids	12-21	HOP homeobox	Homo sapiens	0-3
27494895-0	2016	Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation.	Flavonoids	12-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	74-78
27340105-3	2016	In the present study, the phospholipid complexes of total flavonoids from Persimmon leaves (PLF-PC) was prepared to enhance the oral bioavailability of PLF and to evaluate its antiatherosclerotic properties in atherosclerosis rats in comparison to PLF.	Flavonoids	58-68	periostin	Rattus norvegicus	92-95
27340105-3	2016	In the present study, the phospholipid complexes of total flavonoids from Persimmon leaves (PLF-PC) was prepared to enhance the oral bioavailability of PLF and to evaluate its antiatherosclerotic properties in atherosclerosis rats in comparison to PLF.	Flavonoids	58-68	periostin	Rattus norvegicus	152-155
27340105-3	2016	In the present study, the phospholipid complexes of total flavonoids from Persimmon leaves (PLF-PC) was prepared to enhance the oral bioavailability of PLF and to evaluate its antiatherosclerotic properties in atherosclerosis rats in comparison to PLF.	Flavonoids	58-68	periostin	Rattus norvegicus	152-155
27315330-0	2016	Studies on the interaction between promethazine and human serum albumin in the presence of flavonoids by spectroscopic and molecular modeling techniques.	Flavonoids	91-101	albumin	Homo sapiens	58-71
27315330-9	2016	The decrease in the affinities of PMT binding to HSA in the presence of flavonoids may lead to the increase of free drug in blood, which would affect the transportation or disposition of drug and evoke an adverse or toxic effect.	Flavonoids	72-82	albumin	Homo sapiens	49-52
27258897-0	2016	Identification of androgen receptor antagonists: In vitro investigation and classification methodology for flavonoid.	Flavonoids	107-116	androgen receptor	Homo sapiens	18-35
27315330-6	2016	There was the competitive binding to HSA between PMT and flavonoids because of the overlap of binding sites in HSA.	Flavonoids	57-67	albumin	Homo sapiens	37-40
27315330-6	2016	There was the competitive binding to HSA between PMT and flavonoids because of the overlap of binding sites in HSA.	Flavonoids	57-67	albumin	Homo sapiens	111-114
27496247-0	2016	Flavonoids stimulate cholecystokinin peptide secretion from the enteroendocrine STC-1 cells.	Flavonoids	0-10	cholecystokinin	Homo sapiens	21-36
27496247-6	2016	In this study, we investigated the possible effects of flavonoids (quercetin, kaempferol, apigenin, rutin and baicalein) on stimulation of CCK release in vitro using enteroendocrine STC-1 cells.	Flavonoids	55-65	cholecystokinin	Homo sapiens	139-142
27496247-10	2016	Based on the cell-based results in this work, it can be suggested that the reported activity of flavonoids against food intake and weight could be mediated by stimulation of CCK signal which in turn is responsible for food intake reduction, but future animal and human studies are needed to confirm this conclusion at organism level.	Flavonoids	96-106	cholecystokinin	Homo sapiens	174-177
27370100-1	2016	The flavonoid baicalein has been demonstrated to be an activator of the transcription factor Nrf2 in mammalian cell lines.	Flavonoids	4-13	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
27449398-4	2016	Consequently, the major goal of our study is to identify flavonoids capable of inhibiting HER2 Tyrosine Kinase (HER2-TK) activity and validate their anti-tumor activity against HER2 positive tumors.	Flavonoids	57-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-94
27477310-3	2016	In this study, we tested the hypothesis that quercetin, a flavonoid, induces apoptosis in TRAIL-resistant pancreatic cancer cells.	Flavonoids	58-67	TNF superfamily member 10	Homo sapiens	90-95
27598131-3	2016	Flavonoids are considered as potent anti-photoaging agents due to their UV-absorbing and antioxidant properties and inhibitory activity against UV-mediated MMP induction.	Flavonoids	0-10	matrix metallopeptidase 1	Homo sapiens	156-159
27449398-4	2016	Consequently, the major goal of our study is to identify flavonoids capable of inhibiting HER2 Tyrosine Kinase (HER2-TK) activity and validate their anti-tumor activity against HER2 positive tumors.	Flavonoids	57-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	112-116
27449398-4	2016	Consequently, the major goal of our study is to identify flavonoids capable of inhibiting HER2 Tyrosine Kinase (HER2-TK) activity and validate their anti-tumor activity against HER2 positive tumors.	Flavonoids	57-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	112-116
27449398-5	2016	MAIN METHODS: Molecular docking studies for identifying flavonoids binding at HER2 kinase domain, ADP-Glo  Kinase Assay for determining kinase activity, MTT assay to measure growth inhibition, various apoptotic assays and cell cycle analysis by FACS were performed.	Flavonoids	56-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	78-82
27449398-9	2016	The study also unraveled the anti-proliferative, pro-apoptotic and anti-cancerous activity of these flavonoids against HER2 positive breast cancer cell line.	Flavonoids	100-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	119-123
27449398-10	2016	SIGNIFICANCE: The study identified two citrus fruit flavonoids, NG and HP as HER2-TK inhibitors and this is the first report on their potential to target preferentially and sensitize HER2 positive cancer cells to cell death.	Flavonoids	52-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
27449398-10	2016	SIGNIFICANCE: The study identified two citrus fruit flavonoids, NG and HP as HER2-TK inhibitors and this is the first report on their potential to target preferentially and sensitize HER2 positive cancer cells to cell death.	Flavonoids	52-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	183-187
26833852-3	2016	The results showed that most model flavonoids (from a total of 13) were mainly metabolized into glucuronides in the MDCKII-UGT1A1/MRP2 cells and the glucuronides were rapidly excreted.	Flavonoids	35-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	123-129
26833852-0	2016	Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway.	Flavonoids	95-104	ATP binding cassette subfamily C member 2	Canis lupus familiaris	74-78
26833852-3	2016	The results showed that most model flavonoids (from a total of 13) were mainly metabolized into glucuronides in the MDCKII-UGT1A1/MRP2 cells and the glucuronides were rapidly excreted.	Flavonoids	35-45	ATP binding cassette subfamily C member 2	Canis lupus familiaris	130-134
27143122-2	2016	This flavonoid is an activator of the Nrf2 signalling pathway but the molecular mechanism is not clearly established.	Flavonoids	5-14	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
27143122-6	2016	Baicalein decreased the phosphorylation of Nrf2 (IC50-value approximately 20 muM) suggesting an inhibitory effect of the flavonoid on protein kinases.	Flavonoids	121-130	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
27219053-3	2016	Leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19) is one of three dioxygenases in the flavonoid pathway that catalyzes the formation of anthocyanidins from leucoanthocyanidins.	Flavonoids	89-98	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	0-30
27219053-3	2016	Leucoanthocyanidin dioxygenase (LDOX, EC 1.14.11.19) is one of three dioxygenases in the flavonoid pathway that catalyzes the formation of anthocyanidins from leucoanthocyanidins.	Flavonoids	89-98	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	32-36
27219053-6	2016	Thus, RtLDOX acts as a multifunctional dioxygenase to effect the synthesis of PA and anthocyanins and can perform F3H dioxygenase activities in the flavonoid biosynthesis pathway.	Flavonoids	148-157	flavanone 3-hydroxylase	Arabidopsis thaliana	114-117
27161583-1	2016	Chalcone synthase (CHS, E.C.2.3.1.74) is the first committed enzyme in the flavonoid pathway.	Flavonoids	75-84	chalcone synthase	Vitis vinifera	19-22
27161583-5	2016	The results showed that CHS were mainly accumulated in the grape berry skin, leaves, stem tips and stem phloem, correlated with flavonoids accumulation.	Flavonoids	128-138	chalcone synthase	Vitis vinifera	24-27
27397410-3	2016	The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.	Flavonoids	189-199	homeobox C8	Homo sapiens	49-52
27191791-0	2016	Brain-derived Neurotrophic Factor Signaling Mediates the Antidepressant-like Effect of the Total Flavonoids of Alpiniae Oxyphyllae Fructus in Chronic Unpredictable Mild Stress Mice.	Flavonoids	97-107	brain derived neurotrophic factor	Mus musculus	0-33
27159149-2	2016	Some nutraceuticals, such as flavonoids and natural polyphenols, have recently been investigated as modulators of the self-assembly process of TTR, but they generally suffer from limited bioavailability.	Flavonoids	29-39	transthyretin	Homo sapiens	143-146
27430509-5	2016	In addition, the results also showed that the potato tuber treated with the fungal elicitor80 could systemically induce lignin deposition, total phenolic content, flavonoid content and defense enzymes, including three keys phenylpropanoid pathway (PAL, 4CL and C4H) and pathogenesis-related (GLU and CHT) enzymes.	Flavonoids	163-172	LOW QUALITY PROTEIN: phenylalanine ammonia-lyase-like	Solanum tuberosum	248-251
27397410-3	2016	The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.	Flavonoids	189-199	complement C7	Homo sapiens	125-128
27397410-3	2016	The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.	Flavonoids	189-199	complement C5	Homo sapiens	230-233
27397410-3	2016	The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.	Flavonoids	189-199	complement C4A (Rodgers blood group)	Homo sapiens	237-240
27221774-0	2016	Flavonoid myricetin inhibits TNF-alpha-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-kappaB pathways in human keratinocytes.	Flavonoids	0-9	tumor necrosis factor	Homo sapiens	29-38
27431615-0	2016	Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of Its Vicinal Dihydroxyl Groups of the Catechol Moiety.	Flavonoids	29-38	islet amyloid polypeptide	Homo sapiens	0-6
27431615-2	2016	Numerous flavonoids exhibit inhibitory effects against amylin amyloidosis, but the mechanisms of inhibition remain unclear.	Flavonoids	9-19	islet amyloid polypeptide	Homo sapiens	55-61
27517610-0	2016	Flavonoids as CDK1 Inhibitors: Insights in Their Binding Orientations and Structure-Activity Relationship.	Flavonoids	0-10	cyclin dependent kinase 1	Homo sapiens	14-18
27517610-4	2016	With this in mind, we studied the binding modes of 37 flavonoids (flavones and chalcones) inside the cyclin-dependent PK CDK1 using docking experiments.	Flavonoids	54-64	proliferating cell nuclear antigen	Homo sapiens	101-107
27517610-4	2016	With this in mind, we studied the binding modes of 37 flavonoids (flavones and chalcones) inside the cyclin-dependent PK CDK1 using docking experiments.	Flavonoids	54-64	cyclin dependent kinase 1	Homo sapiens	121-125
27517610-6	2016	In addition, quantitative structure-activity relationship (QSAR) models using CoMFA and CoMSIA methodologies were constructed to explain the trend of the CDK1 inhibitory activities for the studied flavonoids.	Flavonoids	197-207	cyclin dependent kinase 1	Homo sapiens	154-158
27517610-9	2016	Adequate R2 and Q2 values were obtained by each method; interestingly, only hydrophobic and hydrogen bond donor fields describe the differential potency of the flavonoids as CDK1 inhibitors for both defined alignments and subsets.	Flavonoids	160-170	cyclin dependent kinase 1	Homo sapiens	174-178
27221774-0	2016	Flavonoid myricetin inhibits TNF-alpha-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-kappaB pathways in human keratinocytes.	Flavonoids	0-9	AKT serine/threonine kinase 1	Homo sapiens	106-109
27221774-0	2016	Flavonoid myricetin inhibits TNF-alpha-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-kappaB pathways in human keratinocytes.	Flavonoids	0-9	mechanistic target of rapamycin kinase	Homo sapiens	111-115
27221774-0	2016	Flavonoid myricetin inhibits TNF-alpha-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-kappaB pathways in human keratinocytes.	Flavonoids	0-9	nuclear factor kappa B subunit 1	Homo sapiens	120-129
27033553-8	2016	The results demonstrate the explicit role of AtMYB12 in conferring salt and drought tolerance by increasing the levels of flavonoids and ABA in transgenic Arabidopsis.	Flavonoids	122-132	myb domain protein 12	Arabidopsis thaliana	45-52
27626051-0	2016	3D-QSAR modelling dataset of bioflavonoids for predicting the potential modulatory effect on P-glycoprotein activity.	Flavonoids	29-42	ATP binding cassette subfamily B member 1	Homo sapiens	93-107
27491546-9	2016	Three glucosidase genes (EXG1, SPR1, YIR007W) were knocked out using homologous integration, and the EXG1 gene was determined to be the decisive gene of S. cerevisiae in the process of hydrolysing flavonoid glucosides.	Flavonoids	197-206	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	101-105
27486751-3	2016	In this work we show that the production of exopolysaccharide by Sinorhizobium fredii HH103, but not by other S. fredii strains such as USDA257 or NGR234, is repressed by nod gene inducing flavonoids such as genistein and that this repression is dependent on the presence of a functional NodD1 protein.	Flavonoids	189-199	transcriptional regulator NodD1	Sinorhizobium fredii NGR234	288-293
26632982-6	2016	Three structural types of NF-kappaB inhibitors (caffeic acid derivatives, flavonoids and Pentacyclic triterpenes) were characterized.	Flavonoids	74-84	nuclear factor kappa B subunit 1	Homo sapiens	26-35
27350402-4	2016	A 3",4"-dihydroxylated B-ring together with C-ring saturation and hydroxylation were found to be important structural elements, which strongly influence the flavonoid binding and oxidizability by the LPO/MPO redox intermediates Compounds I and II.	Flavonoids	157-166	lactoperoxidase	Homo sapiens	200-203
27350402-4	2016	A 3",4"-dihydroxylated B-ring together with C-ring saturation and hydroxylation were found to be important structural elements, which strongly influence the flavonoid binding and oxidizability by the LPO/MPO redox intermediates Compounds I and II.	Flavonoids	157-166	myeloperoxidase	Homo sapiens	204-207
27350402-5	2016	In combination with docking studies these results allow an understanding of the differences between flavonoids that promote the hypothiocyanite production by LPO and MPO and those that inhibit this enzymatic reaction.	Flavonoids	100-110	lactoperoxidase	Homo sapiens	158-161
27350402-5	2016	In combination with docking studies these results allow an understanding of the differences between flavonoids that promote the hypothiocyanite production by LPO and MPO and those that inhibit this enzymatic reaction.	Flavonoids	100-110	myeloperoxidase	Homo sapiens	166-169
27536314-4	2016	Following bioinformatics approaches, we analyzed the capability of VviGST1, VviGST3, VviGST4, and Arabidopsis TT19 to bind different flavonoids.	Flavonoids	133-143	glutathione S-transferase phi 12	Arabidopsis thaliana	110-114
27536314-6	2016	A total or partial overlap of the binding sites for glutathione and flavonoids was found in VviGST1, and a similar condition was observed in VviGST3 using anthocyanin and flavonols as ligands, whereas VviGST4 and TT19 have both sites for GSH and flavonoids separated.	Flavonoids	68-78	glutathione S-transferase phi 12	Arabidopsis thaliana	213-217
27235587-0	2016	Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-kappaB pathway with anti-inflammatory properties.	Flavonoids	0-10	toll-like receptor 4	Mus musculus	43-47
27235587-0	2016	Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-kappaB pathway with anti-inflammatory properties.	Flavonoids	0-10	lymphocyte antigen 96	Mus musculus	48-52
27235587-0	2016	Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-kappaB pathway with anti-inflammatory properties.	Flavonoids	0-10	mitogen-activated protein kinase 8	Mus musculus	62-65
27235587-0	2016	Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-kappaB pathway with anti-inflammatory properties.	Flavonoids	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-79
27350402-0	2016	Flavonoids as promoters of the (pseudo-)halogenating activity of lactoperoxidase and myeloperoxidase.	Flavonoids	0-10	lactoperoxidase	Homo sapiens	65-80
27350402-0	2016	Flavonoids as promoters of the (pseudo-)halogenating activity of lactoperoxidase and myeloperoxidase.	Flavonoids	0-10	myeloperoxidase	Homo sapiens	85-100
27350402-1	2016	In this study several flavonoids were tested for their potential to regenerate the (pseudo-)halogenating activity (hypothiocyanite formation) of the heme peroxidases lactoperoxidase (LPO) and myeloperoxidase (MPO) after hydrogen peroxide-mediated enzyme inactivation.	Flavonoids	22-32	lactoperoxidase	Homo sapiens	166-181
27350402-1	2016	In this study several flavonoids were tested for their potential to regenerate the (pseudo-)halogenating activity (hypothiocyanite formation) of the heme peroxidases lactoperoxidase (LPO) and myeloperoxidase (MPO) after hydrogen peroxide-mediated enzyme inactivation.	Flavonoids	22-32	lactoperoxidase	Homo sapiens	183-186
27350402-1	2016	In this study several flavonoids were tested for their potential to regenerate the (pseudo-)halogenating activity (hypothiocyanite formation) of the heme peroxidases lactoperoxidase (LPO) and myeloperoxidase (MPO) after hydrogen peroxide-mediated enzyme inactivation.	Flavonoids	22-32	myeloperoxidase	Homo sapiens	192-207
27350402-1	2016	In this study several flavonoids were tested for their potential to regenerate the (pseudo-)halogenating activity (hypothiocyanite formation) of the heme peroxidases lactoperoxidase (LPO) and myeloperoxidase (MPO) after hydrogen peroxide-mediated enzyme inactivation.	Flavonoids	22-32	myeloperoxidase	Homo sapiens	209-212
27279256-0	2016	Combination treatment with flavonoid morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase.	Flavonoids	27-36	signal transducer and activator of transcription 3	Homo sapiens	121-126
27033553-0	2016	AtMYB12 regulates flavonoids accumulation and abiotic stress tolerance in transgenic Arabidopsis thaliana.	Flavonoids	18-28	myb domain protein 12	Arabidopsis thaliana	0-7
27033553-2	2016	The AtMYB12 gene from Arabidopsis thaliana has been shown to regulate the expression of key enzyme genes involved in flavonoid biosynthesis, leading to the increased accumulation of flavonoids.	Flavonoids	117-126	myb domain protein 12	Arabidopsis thaliana	4-11
27033553-2	2016	The AtMYB12 gene from Arabidopsis thaliana has been shown to regulate the expression of key enzyme genes involved in flavonoid biosynthesis, leading to the increased accumulation of flavonoids.	Flavonoids	182-192	myb domain protein 12	Arabidopsis thaliana	4-11
27033553-6	2016	Real-time quantitative PCR (qRT-PCR) analysis showed that overexpression of AtMYB12 resulted in the up-regulation of genes involved in flavonoid biosynthesis, abscisic acid (ABA) biosynthesis, proline biosynthesis, stress responses and ROS scavenging under salt and drought stresses.	Flavonoids	135-144	myb domain protein 12	Arabidopsis thaliana	76-83
27314522-0	2016	Flavonoids from Radix Tetrastigmae improve LPS-induced acute lung injury via the TLR4/MD-2-mediated pathway.	Flavonoids	0-10	toll-like receptor 4	Mus musculus	43-46
27314522-0	2016	Flavonoids from Radix Tetrastigmae improve LPS-induced acute lung injury via the TLR4/MD-2-mediated pathway.	Flavonoids	0-10	toll-like receptor 4	Mus musculus	81-85
27295963-6	2016	Coupled to high performance liquid chromatography, the poly(VHIm(+)PF6(-))@GO@Sil method showed acceptable extraction recoveries for the four flavonoids, with limits of detection in the range of 0.1-0.5mugL(-1), and wide linear ranges with correlation coefficients (R) ranging from 0.9935 to 0.9987.	Flavonoids	142-152	sperm associated antigen 17	Homo sapiens	67-70
27446443-4	2016	The present study was conducted to elucidate the anti-cancer effect and molecular mechanism of flavonoids from Citrus platymamma (FCP) on A549 cells.	Flavonoids	95-105	FCP1	Homo sapiens	130-133
27432888-5	2016	We characterized the flavonoid pathway transcription factor TRANSPARENT TESTA8 (TT8) in Arabidopsis (Arabidopsis thaliana) using an integrative omics strategy.	Flavonoids	21-30	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	72-78
27432888-5	2016	We characterized the flavonoid pathway transcription factor TRANSPARENT TESTA8 (TT8) in Arabidopsis (Arabidopsis thaliana) using an integrative omics strategy.	Flavonoids	21-30	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	80-83
27432888-7	2016	Metabolomics analysis of TT8 loss-of-function and inducible overexpression lines showed that TT8 coordinates glycosylation of not only flavonoids, but also nucleotides, thus implicating TT8 in regulating pools of activated nucleotide sugars.	Flavonoids	135-145	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	93-96
27432888-7	2016	Metabolomics analysis of TT8 loss-of-function and inducible overexpression lines showed that TT8 coordinates glycosylation of not only flavonoids, but also nucleotides, thus implicating TT8 in regulating pools of activated nucleotide sugars.	Flavonoids	135-145	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	93-96
26463658-5	2016	Induction of cell death mechanisms, production of reactive oxygen species, and drug resistance mechanisms, including p-glycoprotein efflux, are among the best-described effects triggered by the flavonoid polyphenol family.	Flavonoids	194-203	ATP binding cassette subfamily B member 1	Homo sapiens	117-131
27058921-2	2016	In this study, at achievable nontoxic plasma concentrations, citrus flavonoid tangeretin has been shown to reverse ABCB1-mediated cancer resistance to a variety of chemotherapeutic agents effectively.	Flavonoids	68-77	ATP binding cassette subfamily B member 1	Homo sapiens	115-120
27295963-6	2016	Coupled to high performance liquid chromatography, the poly(VHIm(+)PF6(-))@GO@Sil method showed acceptable extraction recoveries for the four flavonoids, with limits of detection in the range of 0.1-0.5mugL(-1), and wide linear ranges with correlation coefficients (R) ranging from 0.9935 to 0.9987.	Flavonoids	142-152	STIL centriolar assembly protein	Homo sapiens	78-81
27216424-0	2016	Screening dietary flavonoids for the reversal of P-glycoprotein-mediated multidrug resistance in cancer.	Flavonoids	18-28	ATP binding cassette subfamily B member 1	Homo sapiens	49-63
27216424-6	2016	Based on the computational analysis, selected flavonoids were tested for their inhibitory potential against P-gp transport function in drug resistant cell lines using calcein-AM and rhodamine 123 efflux assays.	Flavonoids	46-56	ATP binding cassette subfamily B member 1	Homo sapiens	108-112
27216424-5	2016	Dietary flavonoids exhibit better interactions with homology modeled human P-gp.	Flavonoids	8-18	ATP binding cassette subfamily B member 1	Homo sapiens	75-79
27216424-7	2016	It has been found that quercetin and rutin were the highly desirable flavonoids for the inhibition of P-gp transport function and they significantly reduced resistance in cytotoxicity assays to paclitaxel in P-gp overexpressing MDR cell lines.	Flavonoids	69-79	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
27399664-6	2016	PC2 contained higher total phenolic content and flavonoid content, whereas PC3 had the lowest amount as compared to other cultivars.	Flavonoids	48-57	chromobox 4	Homo sapiens	0-3
27146015-5	2016	Studies in cell culture and animal models, as well as a limited number of clinical studies, reveal the lipid-lowering, insulin-sensitizing, antihypertensive, and anti-inflammatory properties of citrus flavonoids.	Flavonoids	201-211	insulin	Homo sapiens	119-126
27146015-6	2016	In animal models, supplementation of rodent diets with citrus flavonoids prevents hepatic steatosis, dyslipidemia, and insulin resistance primarily through inhibition of hepatic fatty acid synthesis and increased fatty acid oxidation.	Flavonoids	62-72	insulin	Homo sapiens	119-126
27146015-10	2016	Recent studies support a role for citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity, and atherosclerosis.	Flavonoids	41-51	insulin	Homo sapiens	86-93
26948600-0	2016	Mechanism evaluation of the interactions between flavonoids and bovine serum albumin based on multi-spectroscopy, molecular docking and Q-TOF HR-MS analyses.	Flavonoids	49-59	albumin	Homo sapiens	71-84
27321852-3	2016	METHODS: Here we present the novel use of atmospheric solids analysis probe mass spectrometry (ASAP-MS) for the characterization of flavonoids in pollens.	Flavonoids	132-142	microtubule associated protein 9	Homo sapiens	95-99
27374313-0	2016	Activation of PPARgamma by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.	Flavonoids	37-46	peroxisome proliferator activated receptor gamma	Mus musculus	14-23
26849180-9	2016	The domain/family annotation and phylogenetic analysis allowed us to infer, by homology, potential functions of the genes encoding MYB, HD-ZIP and bZIP-HY5 transcription factors, as well as WD40 protein, which may be involved in anthocyanin and flavonoid regulation in these species.	Flavonoids	245-254	MYB proto-oncogene, transcription factor	Homo sapiens	131-134
27349523-2	2016	The aim of this study was to investigate the mechanism by which the citrus flavonoid, hesperetin, regulates the LDL receptor (LDLr) gene in the human liver using the human hepatoma cell line, HepG2.	Flavonoids	75-84	low density lipoprotein receptor	Homo sapiens	112-124
27618596-2	2016	Baicalin is a natural flavonoid that can reduce skeletal muscle atrophy in animal models of cancer cachexia by inhibiting NF-kappaB.	Flavonoids	22-31	nuclear factor kappa B subunit 1	Homo sapiens	122-131
27351598-13	2016	Serum IL-6 and TNF may define an ASD subgroup that benefits most from treatment with the natural flavonoid luteolin.	Flavonoids	97-106	interleukin 6	Homo sapiens	6-10
27351598-13	2016	Serum IL-6 and TNF may define an ASD subgroup that benefits most from treatment with the natural flavonoid luteolin.	Flavonoids	97-106	tumor necrosis factor	Homo sapiens	15-18
27349523-2	2016	The aim of this study was to investigate the mechanism by which the citrus flavonoid, hesperetin, regulates the LDL receptor (LDLr) gene in the human liver using the human hepatoma cell line, HepG2.	Flavonoids	75-84	low density lipoprotein receptor	Homo sapiens	126-130
27315062-0	2016	A Flavonoid Compound Promotes Neuronal Differentiation of Embryonic Stem Cells via PPAR-beta Modulating Mitochondrial Energy Metabolism.	Flavonoids	2-11	peroxisome proliferator activator receptor delta	Mus musculus	83-92
27315062-9	2016	In conclusion, we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 and mitochondrial Ca2+, PPAR-beta took an important role in neuronal differentiation induced by flavonoid compound 4a.	Flavonoids	191-200	mitofusin 2	Mus musculus	90-94
27315062-9	2016	In conclusion, we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 and mitochondrial Ca2+, PPAR-beta took an important role in neuronal differentiation induced by flavonoid compound 4a.	Flavonoids	191-200	peroxisome proliferator activator receptor delta	Mus musculus	119-128
27012965-0	2016	The bioflavonoid quercetin synergises with PPAR-gamma agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats.	Flavonoids	4-16	angiotensinogen	Rattus norvegicus	87-101
27107807-0	2016	In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish.	Flavonoids	31-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-113
27107807-3	2016	Therefore, the effects of several naturally occurring flavonoids on the activity of CYP3A-dependent 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD) were evaluated in human, pig, mouse, and juvenile rainbow trout sources of hepatic microsomes.	Flavonoids	54-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-89
27145228-2	2016	In previous studies, the authors reported that a flavonoid, quercetin, reduces the expression of ATF4 and delays memory deterioration in an early-stage AD mouse model.	Flavonoids	49-58	activating transcription factor 4	Mus musculus	97-101
26990404-3	2016	In this report, we showed that overexpression of FLS1 (FLS1-OX) not only altered seed coat color (resulting in a light brown color), but also affected flavonoid accumulation.	Flavonoids	151-160	flavonol synthase 1	Arabidopsis thaliana	49-53
27091790-0	2016	Populus nigra (Salicaceae) absolute rich in phenolic acids, phenylpropanoids and flavonoids as a new potent tyrosinase inhibitor.	Flavonoids	81-91	tyrosinase	Mus musculus	108-118
27121925-9	2016	The findings of this study suggest that CLE suppresses Th2-cell-mediated immune responses, contributing to alleviation of food allergy symptoms, and that kaempferol is a flavonoid with potential antiallergenic activity that targets Th2 cell-induced responses.	Flavonoids	170-179	heart and neural crest derivatives expressed 2	Mus musculus	232-235
26865001-4	2016	Flavonoids exhibit melanogenic or anti-melanogenic effects mainly via transcriptional factor MiTF and/or the melanogenesis enzymes tyrosinase, DCT or TYRP-1.	Flavonoids	0-10	melanocyte inducing transcription factor	Homo sapiens	93-97
26865001-4	2016	Flavonoids exhibit melanogenic or anti-melanogenic effects mainly via transcriptional factor MiTF and/or the melanogenesis enzymes tyrosinase, DCT or TYRP-1.	Flavonoids	0-10	dopachrome tautomerase	Homo sapiens	143-146
26865001-4	2016	Flavonoids exhibit melanogenic or anti-melanogenic effects mainly via transcriptional factor MiTF and/or the melanogenesis enzymes tyrosinase, DCT or TYRP-1.	Flavonoids	0-10	tyrosinase related protein 1	Homo sapiens	150-156
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	melanogenesis associated transcription factor	Mus musculus	45-80
27208307-4	2016	In this study, we functionally characterized Arabidopsis (Arabidopsis thaliana) miR858a, which putatively targets R2R3-MYB transcription factors involved in flavonoid biosynthesis.	Flavonoids	157-166	MIR858a	Arabidopsis thaliana	80-87
27000882-1	2016	In the present study, we tested the hypothesis that aldosterone regulates osteopontin (OPN)-related signaling pathways to promote nuclear factor kappaB (NF-kappaB) activation in primary human umbilical vein endothelial cells (HUVECs) and that kaempferol, a flavonoid compound, blocks those changes.	Flavonoids	257-266	secreted phosphoprotein 1	Homo sapiens	74-85
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	melanogenesis associated transcription factor	Mus musculus	82-86
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	tyrosinase	Mus musculus	172-182
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	tyrosinase	Mus musculus	184-187
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	tyrosinase	Mus musculus	241-244
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	tyrosinase-related protein 1	Mus musculus	246-274
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	tyrosinase-related protein 1	Mus musculus	276-280
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	dopachrome tautomerase	Mus musculus	287-315
27000529-3	2016	This flavonoid upregulates the expression of microphthalmia transcription factor (MITF) and reaches its maximum after 24 h. In addition, Sak was found to increase in vitro tyrosinase (Tyr) activity, along with time-dependent upregulation of Tyr, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2 (TRP2).	Flavonoids	5-14	tRNA proline 2	Mus musculus	317-321
27208307-5	2016	Overexpression of miR858a in Arabidopsis led to the down-regulation of several MYB transcription factors regulating flavonoid biosynthesis.	Flavonoids	116-125	MIR858a	Arabidopsis thaliana	18-25
27208307-9	2016	Altogether, our study has established the potential role of light-regulated miR858a in flavonoid biosynthesis and plant growth and development.	Flavonoids	87-96	MIR858a	Arabidopsis thaliana	76-83
26990404-3	2016	In this report, we showed that overexpression of FLS1 (FLS1-OX) not only altered seed coat color (resulting in a light brown color), but also affected flavonoid accumulation.	Flavonoids	151-160	flavonol synthase 1	Arabidopsis thaliana	55-62
26990404-7	2016	Taken together, FLS1 can be manipulated (i.e., silenced or overexpressed) to redirect the flavonoid biosynthetic pathway toward anthocyanin production without negative effects on plant growth and development.	Flavonoids	90-99	flavonol synthase 1	Arabidopsis thaliana	16-20
27043127-4	2016	Anthocyanin, a subclass of the polyphenol family flavonoids has been shown to exhibit anti-dyslipidemic and anti-thrombotic properties by virtue of its antioxidant activity.	Flavonoids	49-59	DDB1 and CUL4 associated factor 7	Homo sapiens	0-11
27061673-0	2016	Inhibitory effect of flavonoids on human glutaminyl cyclase.	Flavonoids	21-31	glutaminyl-peptide cyclotransferase	Homo sapiens	41-59
27184816-1	2016	Licochalcone A (LCA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, presents obvious anti-cancer effects.	Flavonoids	24-33	clathrin light chain A	Homo sapiens	16-19
26843117-4	2016	Glucuronidation of four flavonoids (genistein, biochanin A, apigenin, and chrysin at 2.5-20 muM) were generally more rapid in the hepatic than intestinal microsomes.	Flavonoids	24-34	latexin	Homo sapiens	92-95
27056897-3	2016	The flavonoid compound Icariside II (IS) is a natural mTOR inhibitor derived from Epimedium.	Flavonoids	4-13	mechanistic target of rapamycin kinase	Homo sapiens	54-58
27058612-6	2016	CSP1 with an electron-rich phenyl substitution on the CD rims gave a better resolution for isoxazolines whereas CSP2 with an electron-deficient phenyl substitution on the CD rims gave better resolution for flavonoids.	Flavonoids	206-216	regulator of calcineurin 1	Homo sapiens	0-4
27058612-6	2016	CSP1 with an electron-rich phenyl substitution on the CD rims gave a better resolution for isoxazolines whereas CSP2 with an electron-deficient phenyl substitution on the CD rims gave better resolution for flavonoids.	Flavonoids	206-216	regulator of calcineurin 2	Homo sapiens	112-116
26806540-4	2016	The results of a structure-activity relationship study led to the selection of six flavonoids, all of which activated the TRPA1 channel in a dose-dependent manner.	Flavonoids	83-93	transient receptor potential cation channel subfamily A member 1	Homo sapiens	122-127
26806540-5	2016	Notably, the activation of TRPA1 by these flavonoid aglycones was completely inhibited by the co-treatment of the HEK293T cells with the TRPA1-specific antagonist, HC-030031.	Flavonoids	42-51	transient receptor potential cation channel subfamily A member 1	Homo sapiens	27-32
26806540-5	2016	Notably, the activation of TRPA1 by these flavonoid aglycones was completely inhibited by the co-treatment of the HEK293T cells with the TRPA1-specific antagonist, HC-030031.	Flavonoids	42-51	transient receptor potential cation channel subfamily A member 1	Homo sapiens	137-142
26806540-8	2016	Therefore, these data suggest that the flavonoids would be promising ligands for the TRPA1.	Flavonoids	39-49	transient receptor potential cation channel subfamily A member 1	Homo sapiens	85-90
27194742-3	2016	In particular, bZIP and MYB factors interact synergistically in the recognition of light response units present in the promoter of some genes of the pathway, thus mediating light-dependent flavonoid biosynthesis.	Flavonoids	189-198	ABSCISIC ACID-INSENSITIVE 5-like protein 2	Nicotiana tabacum	15-19
27194742-3	2016	In particular, bZIP and MYB factors interact synergistically in the recognition of light response units present in the promoter of some genes of the pathway, thus mediating light-dependent flavonoid biosynthesis.	Flavonoids	189-198	uncharacterized protein LOC107775040	Nicotiana tabacum	24-27
26108947-0	2016	Evaluation of potential flavonoid inhibitors of glyoxalase-I based on virtual screening and in vitro studies.	Flavonoids	24-33	glyoxalase I	Homo sapiens	48-60
26108947-4	2016	In this study, we performed structure-based virtual screening of focused flavonoids commercial library to identify potential and specific inhibitors of GLO-I.	Flavonoids	73-83	glyoxalase I	Homo sapiens	152-157
26952415-0	2016	Protections of bovine serum albumin protein from damage on functionalized graphene-based electrodes by flavonoids.	Flavonoids	103-113	albumin	Homo sapiens	22-35
27386657-1	2016	OBJECTIVE: To explore the effect of total flavonoids of Herba Epimedium (FHE) on BMP-2/RunX2/OSX signaling pathway in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Flavonoids	42-52	bone morphogenetic protein 2	Homo sapiens	81-86
27279697-0	2016	Flavonoids Derived from Abelmoschus esculentus Attenuates UV-B Induced Cell Damage in Human Dermal Fibroblasts Through Nrf2-ARE Pathway.	Flavonoids	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
27279697-9	2016	SUMMARY: Flavonoid-enriched ethyl acetate (EA) fraction from A. esculentus protected against ultraviolet-B (UV-B)-induced oxidative DNA damageEA fraction prevented UV-B-induced cytotoxicity, depletion of endogenous enzymatic antioxidants, and intracellular reactive oxygen species productionEA fraction could reduce oxidative stress through the Nrf2-ARE PathwayEA fraction was found to be nongenotoxic and prevented apoptotic changes.	Flavonoids	9-18	NFE2 like bZIP transcription factor 2	Homo sapiens	345-349
27279697-10	2016	HIGHLIGHTS: Flavonoids from Abelmoschus esculentus protected from ultraviolet-B-induced damageThey were capable of reducing oxidative stress through Nrf2-ARE PathwayThey are nongenotoxic and do not possess mutagenic potentialFlavonoids from A. esculentus can be studied and explored further for its topical application as sunscreen.	Flavonoids	12-22	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
27386657-1	2016	OBJECTIVE: To explore the effect of total flavonoids of Herba Epimedium (FHE) on BMP-2/RunX2/OSX signaling pathway in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Flavonoids	42-52	RUNX family transcription factor 2	Homo sapiens	87-92
27386657-1	2016	OBJECTIVE: To explore the effect of total flavonoids of Herba Epimedium (FHE) on BMP-2/RunX2/OSX signaling pathway in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Flavonoids	42-52	Sp7 transcription factor	Homo sapiens	93-96
27120588-0	2016	3,5,6,7,8,3",4"-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus.	Flavonoids	46-55	brain derived neurotrophic factor	Mus musculus	130-163
27109240-3	2016	Here we demonstrated how the flavonoid kaempferol stimulated the gene expression and activity of LDLR in HepG2 cells.	Flavonoids	29-38	low density lipoprotein receptor	Homo sapiens	97-101
27120588-1	2016	We previously reported that the citrus flavonoid 3,5,6,7,8,3",4"-heptamethoxyflavone (HMF) increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a transient global ischemia mouse model.	Flavonoids	39-48	brain derived neurotrophic factor	Mus musculus	119-152
27120588-1	2016	We previously reported that the citrus flavonoid 3,5,6,7,8,3",4"-heptamethoxyflavone (HMF) increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a transient global ischemia mouse model.	Flavonoids	39-48	brain derived neurotrophic factor	Mus musculus	154-158
27127689-1	2016	PURPOSE: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction.	Flavonoids	80-89	matrix metallopeptidase 1	Rattus norvegicus	286-312
26931451-7	2016	TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively.	Flavonoids	160-169	long intergenic non-protein coding RNA 1194	Homo sapiens	0-3
26931451-7	2016	TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively.	Flavonoids	160-169	long intergenic non-protein coding RNA 1194	Homo sapiens	8-11
26931451-7	2016	TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively.	Flavonoids	160-169	long intergenic non-protein coding RNA 1194	Homo sapiens	8-11
26931451-7	2016	TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively.	Flavonoids	160-169	long intergenic non-protein coding RNA 1194	Homo sapiens	8-11
26931451-7	2016	TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively.	Flavonoids	160-169	long intergenic non-protein coding RNA 1194	Homo sapiens	8-11
26931451-7	2016	TAG and TAG:HDL-cholesterol ratio were inversely associated with anthocyanidin (-1 25 % change for TAG; -1 60 % change for TAG:HDL-cholesterol ratio) and total flavonoid intakes (-1 31 % change for TAG; -1 83 % change for TAG:HDL-cholesterol ratio), respectively.	Flavonoids	160-169	long intergenic non-protein coding RNA 1194	Homo sapiens	8-11
26991235-2	2016	The cause of DA neuronal loss in PD is still unclear; however, accumulating evidence suggests that treatment with certain flavonoids can induce neuroprotective properties, such as activation of mammalian target of rapamycin complex 1 (mTORC1) and anti-inflammatory activities in animal models of PD.	Flavonoids	122-132	CREB regulated transcription coactivator 1	Mus musculus	235-241
26773068-4	2016	Several flavonoids were evaluated for their ability to acutely relax human and murine ASM ex vivo and murine airways in vivo and were evaluated for their ability to inhibit procontractile signaling pathways in human ASM (hASM) cells.	Flavonoids	8-18	sphingomyelin phosphodiesterase 1	Homo sapiens	86-89
26773068-4	2016	Several flavonoids were evaluated for their ability to acutely relax human and murine ASM ex vivo and murine airways in vivo and were evaluated for their ability to inhibit procontractile signaling pathways in human ASM (hASM) cells.	Flavonoids	8-18	sphingomyelin phosphodiesterase 1	Homo sapiens	216-219
26773068-4	2016	Several flavonoids were evaluated for their ability to acutely relax human and murine ASM ex vivo and murine airways in vivo and were evaluated for their ability to inhibit procontractile signaling pathways in human ASM (hASM) cells.	Flavonoids	8-18	sphingomyelin phosphodiesterase 1	Homo sapiens	221-225
26879600-5	2016	Several studies, mostly based on in vitro and animal models, indicate that dietary polyphenols, mainly flavonoids, positively modulate the insulin signalling pathway by attenuating hyperglycaemia and insulin resistance, reducing inflammatory adipokines, and modifying microRNA (miRNA) profiles.	Flavonoids	103-113	insulin	Homo sapiens	139-146
26879600-5	2016	Several studies, mostly based on in vitro and animal models, indicate that dietary polyphenols, mainly flavonoids, positively modulate the insulin signalling pathway by attenuating hyperglycaemia and insulin resistance, reducing inflammatory adipokines, and modifying microRNA (miRNA) profiles.	Flavonoids	103-113	insulin	Homo sapiens	200-207
27050398-3	2016	We have recently shown that the flavonoid luteolin stabilizes TTR in human plasma with a very high selectivity.	Flavonoids	32-41	transthyretin	Homo sapiens	62-65
27037654-7	2016	Flavonoid-rich extracts also induced antioxidant catalase.	Flavonoids	0-9	catalase	Homo sapiens	49-57
26987380-1	2016	Apigenin is a natural flavonoid compound that can inhibit hypoxia-inducible factor (HIF)-1alpha expression in cultured tumor cells under hypoxic conditions.	Flavonoids	22-31	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	58-95
27012621-0	2016	The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression.	Flavonoids	12-21	hepcidin antimicrobial peptide	Mus musculus	74-82
27012621-4	2016	We found that the dietary flavonoid myricetin significantly inhibited the expression of hepcidin both in vitro and in vivo.	Flavonoids	26-35	hepcidin antimicrobial peptide	Mus musculus	88-96
27127689-1	2016	PURPOSE: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction.	Flavonoids	80-89	matrix metallopeptidase 1	Rattus norvegicus	314-319
27127689-1	2016	PURPOSE: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction.	Flavonoids	80-89	matrix metallopeptidase 8	Rattus norvegicus	322-327
27127689-1	2016	PURPOSE: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction.	Flavonoids	80-89	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	333-372
27127689-1	2016	PURPOSE: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction.	Flavonoids	80-89	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	374-380
26876445-13	2016	Phenolic acids from Chrysanthemi Flos and flavonoids from Citri Reticulatae Pericarpium might be the effective constituents in CTS-E.	Flavonoids	42-52	cathepsin E	Rattus norvegicus	127-132
26899161-0	2016	Tartary buckwheat flavonoids protect hepatic cells against high glucose-induced oxidative stress and insulin resistance via MAPK signaling pathways.	Flavonoids	18-28	insulin	Homo sapiens	101-108
26968518-5	2016	Soybean MATE family could be classified into four subfamilies comprising ten smaller subgroups, with diverse potential functions such as transport and accumulation of flavonoids or alkaloids, extrusion of plant-derived or xenobiotic compounds, regulation of disease resistance, and response to abiotic stresses.	Flavonoids	167-177	aluminum-activated citrate transporter	Glycine max	8-12
26767949-8	2016	Morin, a bioflavonoid given as co- and pre-treatment with acetaminophen significantly prevented the toxicity induced damage by constitutively stabilizing Nrf2 nuclear retention.	Flavonoids	9-21	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
26773261-1	2016	The current study was carried out to investigate the binding mechanism of a potential flavonoid compound 5-hydroxy-3",4",7-trimethoxyflavone (HTMF) with bovine serum albumin (BSA) using ultraviolet-visible, fluorescence, circular dichroism (CD) spectral measurements along with molecular docking and molecular dynamics (MD) simulation.	Flavonoids	86-95	albumin	Homo sapiens	160-173
26998046-0	2016	Total flavonoids of Hedyotis diffusa Willd inhibit inflammatory responses in LPS-activated macrophages via suppression of the NF-kappaB and MAPK signaling pathways.	Flavonoids	6-16	toll-like receptor 4	Mus musculus	77-80
26899161-2	2016	In this study, the protective effect of purified tartary buckwheat flavonoids (TBF) fraction against oxidative stress induced by a high-glucose challenge, which causes insulin resistance, was investigated on hepatic HepG2 cells.	Flavonoids	67-77	insulin	Homo sapiens	168-175
26927197-7	2016	GSTP1 displayed lower affinities in the micromolar range towards all of the flavonoids tested.	Flavonoids	76-86	glutathione S-transferase pi 1	Homo sapiens	0-5
26824623-6	2016	Furthermore, the flavonoid fraction of Herba Epimedii also increased osteoprotegerin protein expression and reduced the receptor activator of nuclear factor-kappaB ligand protein expression compared with ovariectomized rats.	Flavonoids	17-26	TNF receptor superfamily member 11B	Rattus norvegicus	69-84
26824623-6	2016	Furthermore, the flavonoid fraction of Herba Epimedii also increased osteoprotegerin protein expression and reduced the receptor activator of nuclear factor-kappaB ligand protein expression compared with ovariectomized rats.	Flavonoids	17-26	TNF superfamily member 11	Rattus norvegicus	120-170
26917158-4	2016	Constitutive expression of AtMYB12 in tomato led to a significantly enhanced biosynthesis of flavonoids in general and the flavonol biosynthesis in particular.	Flavonoids	93-103	myb domain protein 12	Arabidopsis thaliana	27-34
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Flavonoids	58-68	glutathione S-transferase pi 1	Homo sapiens	201-239
26824620-5	2016	The levels of chemokine (C-X-C motif) ligand 1, tumor necrosis factor-alpha, and interleukin-1beta quantified by the enzyme-linked immunosorbent assay (ELISA) in the periarticular tissue were also diminished in mice treated with the 70% ethanol extract and flavonoid-rich fraction, as well as mechanical hypernociception.	Flavonoids	257-266	chemokine (C-X-C motif) ligand 1	Mus musculus	14-75
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Flavonoids	58-68	glutathione S-transferase pi 1	Homo sapiens	241-246
26927197-8	2016	The interactions of flavonoids with HSA and GSTP1 were studied successfully using this novel SPR assay method.	Flavonoids	20-30	glutathione S-transferase pi 1	Homo sapiens	44-49
26774038-0	2016	Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.	Flavonoids	0-9	ATP binding cassette subfamily C member 1	Homo sapiens	35-40
26732631-7	2016	RESULTS: Among the investigated active fractions, the flavonoids from Carthamus tinctorius (Fct), Davallia mariesii (Fdm), and Cinnamomum cassia Twig volatile oils (Vca) from the eight selected herbs effectively promoted IL-1beta and IL-6 release from ANA-1 cells.	Flavonoids	54-64	interleukin 1 beta	Mus musculus	221-229
26732631-7	2016	RESULTS: Among the investigated active fractions, the flavonoids from Carthamus tinctorius (Fct), Davallia mariesii (Fdm), and Cinnamomum cassia Twig volatile oils (Vca) from the eight selected herbs effectively promoted IL-1beta and IL-6 release from ANA-1 cells.	Flavonoids	54-64	interleukin 6	Mus musculus	234-238
26583522-5	2016	Combined with the fact that flavonoids and CU have the same binding site (site I), it can be concluded that they may simultaneously bind in different regions in site I, and formed a ternary complex of flavonoid-HSA-CU.	Flavonoids	28-37	albumin	Homo sapiens	211-214
26583522-6	2016	Meanwhile, the results of fluorescence quenching, CD and three-dimensional fluorescence spectra revealed that flavonoids further strengthened the microenvironmental and conformational changes of HSA induced by CU binding.	Flavonoids	110-120	albumin	Homo sapiens	195-198
26583522-2	2016	The results showed that the fluorescence quenching of HSA by CU was a simultaneous static and dynamic quenching process, irrespective of the presence or absence of flavonoids.	Flavonoids	164-174	albumin	Homo sapiens	54-57
26628272-0	2016	Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood.	Flavonoids	36-46	insulin	Homo sapiens	137-144
26583522-3	2016	The binding constants between CU and HSA in the absence and presence of rutin and baicalin were 2.268x10(5)M(-1), 3.062x10(5)M(-1), and 3.271x10(5)M(-1), indicating that the binding affinity was increased in the case of two flavonoids.	Flavonoids	224-234	albumin	Homo sapiens	37-40
26583522-5	2016	Combined with the fact that flavonoids and CU have the same binding site (site I), it can be concluded that they may simultaneously bind in different regions in site I, and formed a ternary complex of flavonoid-HSA-CU.	Flavonoids	28-38	albumin	Homo sapiens	211-214
26628272-0	2016	Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood.	Flavonoids	36-46	insulin like growth factor 1	Homo sapiens	165-170
26628272-0	2016	Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood.	Flavonoids	36-46	insulin like growth factor binding protein 2	Homo sapiens	197-204
26628272-0	2016	Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood.	Flavonoids	36-46	insulin like growth factor binding protein 3	Homo sapiens	209-216
26628272-4	2016	We used data from Dortmund Nutritional and Anthropometric Longitudinally Designed Study participants to analyse prospective associations between FV, fruit intake and flavonoid intake from FV (FlavFV) with IGF-1 and its binding proteins IGFBP-2 and IGFBP-3.	Flavonoids	166-175	insulin like growth factor 1	Homo sapiens	205-210
26628272-4	2016	We used data from Dortmund Nutritional and Anthropometric Longitudinally Designed Study participants to analyse prospective associations between FV, fruit intake and flavonoid intake from FV (FlavFV) with IGF-1 and its binding proteins IGFBP-2 and IGFBP-3.	Flavonoids	166-175	insulin like growth factor binding protein 2	Homo sapiens	236-243
26861281-0	2016	Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.	Flavonoids	13-23	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	87-91
26909969-6	2016	Three flavonoid components in Xiaoyao powder increased the expression of proteins and mRNA of ERalpha and ERbeta and promoted the proliferation of MCF-7 cells.	Flavonoids	6-15	estrogen receptor 1	Homo sapiens	94-101
26909969-6	2016	Three flavonoid components in Xiaoyao powder increased the expression of proteins and mRNA of ERalpha and ERbeta and promoted the proliferation of MCF-7 cells.	Flavonoids	6-15	estrogen receptor 2	Homo sapiens	106-112
26853104-2	2016	Recently, a flavonoid-rich extract of Citrus bergamia juice (BJe) has been shown to display anti-oxidant and anti-inflammatory properties against LPS-induced activation of human THP-1 monocytes.	Flavonoids	12-21	GLI family zinc finger 2	Homo sapiens	178-183
26861281-0	2016	Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.	Flavonoids	13-23	eukaryotic translation elongation factor 2	Homo sapiens	93-97
26861281-0	2016	Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.	Flavonoids	13-23	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	99-103
26861281-0	2016	Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.	Flavonoids	13-23	eukaryotic translation initiation factor 4E	Homo sapiens	108-113
26861281-7	2016	Furthermore, the flavonoids 2, 3, 4, 7, and 10 induced phosphorylation of the AMP-activated protein kinase (AMPK) and the eukaryotic elongation factor 2 (eEF2).	Flavonoids	17-27	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	78-106
26861281-7	2016	Furthermore, the flavonoids 2, 3, 4, 7, and 10 induced phosphorylation of the AMP-activated protein kinase (AMPK) and the eukaryotic elongation factor 2 (eEF2).	Flavonoids	17-27	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	108-112
26861281-7	2016	Furthermore, the flavonoids 2, 3, 4, 7, and 10 induced phosphorylation of the AMP-activated protein kinase (AMPK) and the eukaryotic elongation factor 2 (eEF2).	Flavonoids	17-27	eukaryotic translation elongation factor 2	Homo sapiens	122-152
26861281-7	2016	Furthermore, the flavonoids 2, 3, 4, 7, and 10 induced phosphorylation of the AMP-activated protein kinase (AMPK) and the eukaryotic elongation factor 2 (eEF2).	Flavonoids	17-27	eukaryotic translation elongation factor 2	Homo sapiens	154-158
26708302-0	2016	Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2.	Flavonoids	42-51	pyruvate kinase M1/2	Homo sapiens	73-101
26841115-0	2016	Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1alpha in Chondrocytes and Promotes Articular Cartilage Repair.	Flavonoids	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-68
26841115-6	2016	In this study, using phenotypic cellular screen assays, we identify that Icariin, an active flavonoid component from Herba Epimedii, activates HIF-1alpha expression in chondrocytes.	Flavonoids	92-101	hypoxia inducible factor 1, alpha subunit	Mus musculus	143-153
26708302-5	2016	In this study, the effects of various flavonoid derivatives on the PKM2 enzyme activity were analyzed in vitro.	Flavonoids	38-47	pyruvate kinase M1/2	Homo sapiens	67-71
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonoids	58-67	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	125-142
26565375-0	2016	Natural and synthetic flavonoid modulation of TRPC5 channels.	Flavonoids	22-31	transient receptor potential cation channel subfamily C member 5	Homo sapiens	46-51
26565375-13	2016	CONCLUSIONS AND IMPLICATIONS: The data suggest that galangin (a natural product from the ginger family) is a TRPC5 inhibitor and that other natural and synthetic flavonoids contain antagonist or agonist capabilities at TRPC5 and closely related channels depending on the substitution patterns of both the chromone core and the phenyl ring.	Flavonoids	162-172	transient receptor potential cation channel subfamily C member 5	Homo sapiens	219-224
26601822-4	2016	We found that, in GFP-LKP2 hypocotyls, 775 genes were up-regulated, including 36 auxin-responsive genes, such as 27 SMALL AUXIN UP RNA (SAUR) and 6 AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) genes, and 21 genes involved in responses to red or far-red light, including PHYTOCHROME-INTERACTING FACTOR4 (PIF4) and PIF5; and 725 genes were down-regulated, including 15 flavonoid biosynthesis genes.	Flavonoids	359-368	LOV KELCH protein 2	Arabidopsis thaliana	22-26
26834825-0	2016	Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous.	Flavonoids	34-44	tyrosinase	Homo sapiens	0-10
26598088-0	2016	Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via microRNA in high fat diet induced obesity mice.	Flavonoids	42-51	4-hydroxyphenylpyruvic acid dioxygenase	Mus musculus	64-67
26598088-1	2016	3-O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl]kaempferol (Fla-CN), a semi-synthesized flavonoid derivative of tiliroside, reduces whole-body adiposity, ameliorates metabolic lipid disorder, improves insulin sensitivity and benefits other disorders characterized by insulin resistance in high fat diet induced obesity mice.	Flavonoids	86-95	4-hydroxyphenylpyruvic acid dioxygenase	Mus musculus	58-61
26722818-0	2016	Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study.	Flavonoids	64-73	aldehyde oxidase 1	Homo sapiens	25-41
26722818-6	2016	Then, inhibitory effects of 10 flavonoid compounds including 8 derivatives of 2-benzylidenebenzofuran-3(2H)-ones, as well as naringenin and ellagic acid on the activity of aldehyde oxidase were assessed compared with the specific inhibitor of AO, menadione.	Flavonoids	31-40	aldehyde oxidase 1	Homo sapiens	172-188
26639663-2	2016	Tanshinone IIA (Tan IIA) is a well-known flavonoid that elicits an important therapeutic effect by inhibiting inflammatory response.	Flavonoids	41-50	ATPase, class II, type 9A	Mus musculus	11-14
26639663-2	2016	Tanshinone IIA (Tan IIA) is a well-known flavonoid that elicits an important therapeutic effect by inhibiting inflammatory response.	Flavonoids	41-50	ATPase, class II, type 9A	Mus musculus	20-23
25821013-6	2016	CONCLUSION: Data indicate that levels of total phenolic and flavonoid compounds in potato are controlled primarily by PAL and CHS gene expression.	Flavonoids	60-69	chalcone synthase 1A	Solanum tuberosum	126-129
26706021-1	2016	Flavonoid resveratrol modulates the transcription factor NF-kappaB; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases.	Flavonoids	0-9	nuclear factor kappa B subunit 1	Homo sapiens	57-66
26706021-1	2016	Flavonoid resveratrol modulates the transcription factor NF-kappaB; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases.	Flavonoids	0-9	tumor protein p53	Homo sapiens	231-234
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonoids	58-67	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	144-147
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonoids	58-67	dihydroflavonol-4-reductase	Nicotiana tabacum	153-180
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonoids	58-67	dihydroflavonol-4-reductase	Nicotiana tabacum	182-185
27935888-8	2016	Assessing dynamics of the vWF level after 3 months on the background of using natural-origin flavonoids (the Study Group) showed a more pronounced decrease in the vWF level in the Study Group patients as compared with the Control Group patients (98.4%).	Flavonoids	93-103	von Willebrand factor	Homo sapiens	26-29
27935888-8	2016	Assessing dynamics of the vWF level after 3 months on the background of using natural-origin flavonoids (the Study Group) showed a more pronounced decrease in the vWF level in the Study Group patients as compared with the Control Group patients (98.4%).	Flavonoids	93-103	von Willebrand factor	Homo sapiens	163-166
26759700-5	2016	Flavonoids, another important components of GBE, were shown anti-inflammatory effect in a different way from Ginkgolide A which might be independent on PXR because flavonoids significantly inhibited CYP3A11 activities in mice.	Flavonoids	0-10	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	199-206
27509931-0	2016	Morin, a Flavonoid from Moraceae, Inhibits Cancer Cell Adhesion to Endothelial Cells and EMT by Downregulating VCAM1 and Ncadherin.	Flavonoids	9-18	IL2 inducible T cell kinase	Homo sapiens	89-92
27509931-0	2016	Morin, a Flavonoid from Moraceae, Inhibits Cancer Cell Adhesion to Endothelial Cells and EMT by Downregulating VCAM1 and Ncadherin.	Flavonoids	9-18	vascular cell adhesion molecule 1	Homo sapiens	111-116
27509931-0	2016	Morin, a Flavonoid from Moraceae, Inhibits Cancer Cell Adhesion to Endothelial Cells and EMT by Downregulating VCAM1 and Ncadherin.	Flavonoids	9-18	cadherin 2	Homo sapiens	121-130
26759700-5	2016	Flavonoids, another important components of GBE, were shown anti-inflammatory effect in a different way from Ginkgolide A which might be independent on PXR because flavonoids significantly inhibited CYP3A11 activities in mice.	Flavonoids	164-174	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	199-206
26602279-2	2016	Through a high-throughput screening approach started from 6400 representative compounds in the Korea Chemical Bank chemical library, we identified 11 novel PTPsigma inhibitors that can be classified as flavonoid derivatives or analogs, with IC50 values ranging from 0.5 to 17.5muM.	Flavonoids	202-211	protein tyrosine phosphatase, receptor type, S	Rattus norvegicus	156-164
27833438-0	2016	The inhibitory effect of flavonoids on interleukin-8 release by human gastric adenocarcinoma (AGS) cells infected with cag PAI (+) Helicobacter pylori.	Flavonoids	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
26515162-0	2016	Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells.	Flavonoids	72-81	aryl hydrocarbon receptor	Homo sapiens	0-25
26892733-7	2016	The effect of specific flavonoids as well as their interactions with other factors on associations between SULT1A1 alleles and cancer risk certainly needs further thorough studies.	Flavonoids	23-33	sulfotransferase family 1A member 1	Homo sapiens	107-114
27558014-0	2016	Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics.	Flavonoids	50-60	elastase, neutrophil expressed	Homo sapiens	6-25
26844571-4	2016	Among such compounds, flavonoids found in natural sources, like quercetin, genistein, epigallocatechins, resveratrol, have been proposed as AMPK activators.	Flavonoids	22-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	140-144
26892733-0	2016	Sulfotransferase 1A1 as a Biomarker for Susceptibility to Carcinogenesis: From Molecular Genetics to the Role of Dietary Flavonoids.	Flavonoids	121-131	sulfotransferase family 1A member 1	Homo sapiens	0-20
26892733-5	2016	RESULTS AND CONCLUSION: In this review article, we show that one more important determinant should be considered as a stratifying factor in studies of possible associations between SULT1A1 variants and cancer risk, i.e., the dietary intake of different flavonoids.	Flavonoids	253-263	sulfotransferase family 1A member 1	Homo sapiens	181-188
26268338-0	2016	In Vitro Inhibition of Glyoxalase I by Flavonoids: New Insights from Crystallographic Analysis.	Flavonoids	39-49	glyoxalase I	Homo sapiens	23-35
26268338-1	2016	The antitumor pharmacological property of flavonoids is correlated with inhibition towards glyoxalase I (GLOI), a critical zinc-enzyme in the methylglyoxal detoxification pathway.	Flavonoids	42-52	glyoxalase I	Homo sapiens	91-103
26268338-1	2016	The antitumor pharmacological property of flavonoids is correlated with inhibition towards glyoxalase I (GLOI), a critical zinc-enzyme in the methylglyoxal detoxification pathway.	Flavonoids	42-52	glyoxalase I	Homo sapiens	105-109
26268338-4	2016	The coordination ability of flavonoids, and therefore their ability to inhibit GLOI, is determined by the Zn(2+) coordination geometry, the rigid skeleton of flavonoids and the geometry of the hydrophobic cavity of the GLOI active site.	Flavonoids	28-38	glyoxalase I	Homo sapiens	79-83
26268338-4	2016	The coordination ability of flavonoids, and therefore their ability to inhibit GLOI, is determined by the Zn(2+) coordination geometry, the rigid skeleton of flavonoids and the geometry of the hydrophobic cavity of the GLOI active site.	Flavonoids	28-38	glyoxalase I	Homo sapiens	219-223
26268338-4	2016	The coordination ability of flavonoids, and therefore their ability to inhibit GLOI, is determined by the Zn(2+) coordination geometry, the rigid skeleton of flavonoids and the geometry of the hydrophobic cavity of the GLOI active site.	Flavonoids	158-168	glyoxalase I	Homo sapiens	79-83
25893707-5	2016	Taxifolin, as a naturally bioactive flavonoid, has a K(i) of 29.2 nM against hCA I, and 24.2 nM against hCA II.	Flavonoids	36-45	carbonic anhydrase 1	Homo sapiens	77-82
25893707-5	2016	Taxifolin, as a naturally bioactive flavonoid, has a K(i) of 29.2 nM against hCA I, and 24.2 nM against hCA II.	Flavonoids	36-45	carbonic anhydrase 2	Homo sapiens	104-110
24937381-0	2016	Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations.	Flavonoids	6-15	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	94-108
26212963-2	2016	As a kind of potentially safer alpha-glucosidase inhibitor, flavonoids have attached much attention currently.	Flavonoids	60-70	sucrase-isomaltase	Homo sapiens	31-48
25798688-0	2016	In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2.	Flavonoids	25-35	pyruvate kinase M1/2	Homo sapiens	64-92
27558014-2	2016	In an intensive hunt for human neutrophil elastase inhibitors, we isolated eight flavonoids from C. hirtella three of which (1-3) emerged to be elastase inhibitors.	Flavonoids	81-91	elastase, neutrophil expressed	Homo sapiens	31-50
27558014-3	2016	Geranylated flavonoids (1-3) displayed significant inhibitory activity with IC50s between 8.5 and 30.8 muM.	Flavonoids	12-22	latexin	Homo sapiens	103-106
28044092-0	2016	Comparative Analysis of the Interaction between Different Flavonoids and PDIA3.	Flavonoids	58-68	protein disulfide isomerase family A member 3	Homo sapiens	73-78
26943884-3	2016	Flavonoids, like quercetin, are GLUT-1 competitive inhibitors and may be considered as potential therapeutic agents for PLTs.	Flavonoids	0-10	solute carrier family 2 member 1	Homo sapiens	32-38
28044092-4	2016	The interaction of different flavonoids with PDIA3 was investigated by quenching fluorescence analysis and the effects on protein activity were evaluated.	Flavonoids	29-39	protein disulfide isomerase family A member 3	Homo sapiens	45-50
28044092-6	2016	The use of several flavonoids differing in chemical structure and functional groups allows us to make some consideration about the relationship between ligand structure and the affinity for PDIA3.	Flavonoids	19-29	protein disulfide isomerase family A member 3	Homo sapiens	190-195
26497001-7	2016	Expression analysis of flavonoid structural genes revealed the strong down-regulation of the flavonoid-related genes anthocyanidin synthase (ANS) and dihydroflavonol reductase (DFR) genes and also the reduction of the anthocyanin-related gene UDP glucose:flavonoid 3-O-glucosyl transferase (UFGT), which was dependent of the transgene expression.	Flavonoids	23-32	cinnamoyl-CoA reductase 1-like	Nicotiana tabacum	150-175
26710980-10	2016	Discussion and conclusion The current results suggested that the anti-inflammatory activity of three flavonoids was mainly manifested in the reduction of production of NO and IL-6 production.	Flavonoids	101-111	interleukin 6	Mus musculus	175-179
26366751-9	2016	Quercetin-like flavonoids such as kaempferol stimulated the vitamin D receptor activity in a manner similar to that seen with quercetin.	Flavonoids	15-25	vitamin D receptor	Homo sapiens	60-78
26412505-0	2016	Simultaneous Detection of Flavonoids, Phenolic Acids and Alkaloids in Abri Herba and Abri Mollis Herba using Liquid Chromatography Tandem Mass Spectrometry.	Flavonoids	26-36	integral membrane protein 2B	Homo sapiens	70-74
29023018-5	2016	This study consist 2 steps, first to determinate, extraction and fractionation anthill plant and carry out tonicity test to get flavonoid fraction from anthill plant which has anticancer potential against tongue cancer cell SP-C1.	Flavonoids	128-137	signal peptidase complex subunit 1	Homo sapiens	224-229
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	Flavonoids	276-285	AKT serine/threonine kinase 1	Homo sapiens	83-86
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	Flavonoids	276-285	nuclear factor kappa B subunit 1	Homo sapiens	135-157
29023018-12	2016	On ELISA testing and Western blotting analysis, inhibiton of protein expression of Akt signal transduction and transcription factor of nuclear factor-kappa B (NF-kappaB) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-kappaB and growth factors that induces the phosphorylation of Akt signal transduction pathway.	Flavonoids	276-285	nuclear factor kappa B subunit 1	Homo sapiens	159-168
29023018-13	2016	CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue.	Flavonoids	35-44	AKT serine/threonine kinase 1	Homo sapiens	137-140
29023018-13	2016	CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue.	Flavonoids	35-44	nuclear factor kappa B subunit 1	Homo sapiens	145-167
29023018-13	2016	CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-kappaB) squamous cell carcinoma of the tongue.	Flavonoids	35-44	nuclear factor kappa B subunit 1	Homo sapiens	169-178
26412505-4	2016	OBJECTIVE: To establish a high-performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS) method for the simultaneous analysis of 15 flavonoids, two phenolic acids and three alkaloids in Abri Herba and Abri mollis Herba.	Flavonoids	150-160	integral membrane protein 2B	Homo sapiens	204-208
26497001-7	2016	Expression analysis of flavonoid structural genes revealed the strong down-regulation of the flavonoid-related genes anthocyanidin synthase (ANS) and dihydroflavonol reductase (DFR) genes and also the reduction of the anthocyanin-related gene UDP glucose:flavonoid 3-O-glucosyl transferase (UFGT), which was dependent of the transgene expression.	Flavonoids	23-32	cinnamoyl-CoA reductase 1-like	Nicotiana tabacum	177-180
26497001-7	2016	Expression analysis of flavonoid structural genes revealed the strong down-regulation of the flavonoid-related genes anthocyanidin synthase (ANS) and dihydroflavonol reductase (DFR) genes and also the reduction of the anthocyanin-related gene UDP glucose:flavonoid 3-O-glucosyl transferase (UFGT), which was dependent of the transgene expression.	Flavonoids	93-102	cinnamoyl-CoA reductase 1-like	Nicotiana tabacum	150-175
26497001-7	2016	Expression analysis of flavonoid structural genes revealed the strong down-regulation of the flavonoid-related genes anthocyanidin synthase (ANS) and dihydroflavonol reductase (DFR) genes and also the reduction of the anthocyanin-related gene UDP glucose:flavonoid 3-O-glucosyl transferase (UFGT), which was dependent of the transgene expression.	Flavonoids	93-102	cinnamoyl-CoA reductase 1-like	Nicotiana tabacum	177-180
26770028-0	2015	Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer.	Flavonoids	36-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-60
27319172-8	2016	The comparison study on the enantioseparation of nine flavonoids with the two CSPs demonstrates the higher enantioselectivities of CSP1 over CSP2, because of the different locations of electron-donating (methyl) and withdrawing (chlorine) groups in the phenylcarbamate moieties of CD derivatives.	Flavonoids	54-64	regulator of calcineurin 1	Homo sapiens	131-135
27319172-8	2016	The comparison study on the enantioseparation of nine flavonoids with the two CSPs demonstrates the higher enantioselectivities of CSP1 over CSP2, because of the different locations of electron-donating (methyl) and withdrawing (chlorine) groups in the phenylcarbamate moieties of CD derivatives.	Flavonoids	54-64	regulator of calcineurin 2	Homo sapiens	141-145
26608698-9	2016	During development, FFT promoter activity was detected in the seed-coat layers that accumulate flavonoids.	Flavonoids	95-105	detoxifying efflux carrier 35	Arabidopsis thaliana	20-23
30645899-1	2016	Flavonoids rutin (R) and hesperidin (Hes) have a broad spectrum of the biological activity based on their antiradical properties and ability to increase the activity of antioxidant enzymes, including the activity of heme oxygenase-1 (HO-1) and NAD(P)H-quinone oxidoreductase (QR).	Flavonoids	0-10	heme oxygenase 1	Rattus norvegicus	216-232
26669576-2	2015	This study aimed to evaluate the potential of radioiodinated flavonoid derivatives for single photon emission computed tomography (SPECT) imaging of PrP(Sc).	Flavonoids	61-70	prion protein	Mus musculus	149-152
27255042-6	2016	(2) Compared with that of CVB3 infected group, GRP78 expression level was decreased, and the expression levels of calumenin and CX43 were increased in total flavonoids of astragalus group.	Flavonoids	157-167	calumenin	Rattus norvegicus	114-123
27255042-8	2016	On the other hand, total flavonoids of astragalus can reduce the expression of GRP78 and increase the expression of calumenin and CX43.The results of this experiment may be closely related to the effects of anti-arrhythmia with viral myocarditis caused by CVB3.	Flavonoids	25-35	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	79-84
27255042-8	2016	On the other hand, total flavonoids of astragalus can reduce the expression of GRP78 and increase the expression of calumenin and CX43.The results of this experiment may be closely related to the effects of anti-arrhythmia with viral myocarditis caused by CVB3.	Flavonoids	25-35	calumenin	Rattus norvegicus	116-125
26593216-17	2015	Flavonoids mainly accountable for the uric acid lowering effect of L. nodiflora through the inhibition of XOD/XDH activities.	Flavonoids	0-10	xanthine dehydrogenase	Rattus norvegicus	110-113
26679063-6	2015	Sample A showed enhanced activity of flavonoid and terpenoid biosynthesis related genes, i.e. ERF, MYB, bHLH, bZIP and WRKY.	Flavonoids	37-46	ETS2 repressor factor	Homo sapiens	94-97
26679063-6	2015	Sample A showed enhanced activity of flavonoid and terpenoid biosynthesis related genes, i.e. ERF, MYB, bHLH, bZIP and WRKY.	Flavonoids	37-46	MYB proto-oncogene, transcription factor	Homo sapiens	99-102
27255042-1	2016	OBJECTIVE: To investigate the effect of total flavonoids of astragalus on the expression of endoplasmic reticulum chaperone, calumenin and connecxin 43 (CX43) in suckling mouse myocardium with myocarditis caused by coxsackievirus B3 (CVB3).	Flavonoids	46-56	calumenin	Mus musculus	125-134
26730179-6	2016	Increased expression of neurotrophic factors in vitro and in vivo is the mechanism of neurotrophic action of flavonoids such as scutellarin, daidzein, genistein, and fisetin, while compounds like apigenin and ferulic acid increase cyclic adenosine monophosphate response element-binding protein (CREB) phosphorylation.	Flavonoids	109-119	cAMP responsive element binding protein 1	Rattus norvegicus	296-300
26674355-2	2015	Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress by activating the Keap1-Nrf2-ARE signaling pathway, thus increasing the expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and catalase.	Flavonoids	41-50	kelch like ECH associated protein 1	Homo sapiens	128-133
26674355-2	2015	Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress by activating the Keap1-Nrf2-ARE signaling pathway, thus increasing the expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and catalase.	Flavonoids	41-50	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
26674355-2	2015	Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress by activating the Keap1-Nrf2-ARE signaling pathway, thus increasing the expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and catalase.	Flavonoids	41-50	heme oxygenase 1	Homo sapiens	225-241
26674355-2	2015	Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress by activating the Keap1-Nrf2-ARE signaling pathway, thus increasing the expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and catalase.	Flavonoids	41-50	heme oxygenase 1	Homo sapiens	243-247
26669576-3	2015	In vitro binding assays using recombinant mouse PrP (rMoPrP) aggregates revealed that the 4-dimethylamino-substituted styrylchromone derivative (SC-NMe2) had higher in vitro binding affinity (Kd = 24.5 nM) and capacity (Bmax = 36.3 pmol/nmol protein) than three other flavonoid derivatives (flavone, chalcone, and aurone).	Flavonoids	268-277	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	148-152
26416505-2	2015	Acetylation of these C-6 or C-8 Mannich bases with potassium acetate in acetic anhydride provided access to the corresponding acetoxymethyl derivatives that were subsequently converted to hydroxymethyl- and methoxymethyl-substituted 5-hydroxy- or 7-hydroxyisoflavonoids related to naturally occurring flavonoids.	Flavonoids	259-269	complement C6	Homo sapiens	21-24
26885210-4	2015	After mice were treated with flavonoids, the content of malonaldehyde (MDA) in serum and liver decreased; the activities of superoxide dismutase (SOD) in serum and liver, catalase (CAT) in liver and glutathione peroxidase (GSH-PX) in blood and liver increased; Langhans cells increased in spleen.	Flavonoids	29-39	catalase	Mus musculus	171-179
26636322-10	2015	Particularly, some flavonoid biosynthetic pathway genes, including C4H, CHS, CHI, F3H, DFR and ANS, as well as some transcription factors (TFs), including MYB (putative MYB86 and MYB39), WDR and MADS, were down-regulated in YW fruit, concurrent with a reduction in anthocyanin accumulation in the yellow pigment phenotype, whereas a putative transcription repressor MYB1R was up-regulated in YW fruit.	Flavonoids	19-28	bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase-like	Fragaria vesca	87-90
26468275-3	2015	Comparative analyses of the interaction and of the ability to protect the TTR native state for polyphenols, both stilbenoids and flavonoids, and some of their main metabolites have been carried out.	Flavonoids	129-139	transthyretin	Homo sapiens	74-77
26450448-2	2015	In the present study, we investigate the effects of eriodictyol, a flavonoid found naturally in citrus fruits, on the receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation using mouse bone marrow macrophages (BMMs).	Flavonoids	67-76	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	170-175
26408079-5	2015	Flavonoids also induced a delay in cell migration, related to a reduction in filopodia-like structures on the cell surface, reduction on metalloproteinase (MMP-2) expression and activity, as well as an increase in intra- and extracellular expression of fibronectin, and intracellular expression of laminin.	Flavonoids	0-10	matrix metallopeptidase 2	Homo sapiens	156-161
26408079-5	2015	Flavonoids also induced a delay in cell migration, related to a reduction in filopodia-like structures on the cell surface, reduction on metalloproteinase (MMP-2) expression and activity, as well as an increase in intra- and extracellular expression of fibronectin, and intracellular expression of laminin.	Flavonoids	0-10	fibronectin 1	Homo sapiens	253-264
26636322-10	2015	Particularly, some flavonoid biosynthetic pathway genes, including C4H, CHS, CHI, F3H, DFR and ANS, as well as some transcription factors (TFs), including MYB (putative MYB86 and MYB39), WDR and MADS, were down-regulated in YW fruit, concurrent with a reduction in anthocyanin accumulation in the yellow pigment phenotype, whereas a putative transcription repressor MYB1R was up-regulated in YW fruit.	Flavonoids	19-28	transcription factor MYB12-like	Fragaria vesca	179-184
26449282-0	2015	Involvement of a Hydrophobic Pocket and Helix 11 in Determining the Modes of Action of Prenylated Flavonoids and Isoflavonoids in the Human Estrogen Receptor.	Flavonoids	98-108	estrogen receptor 1	Homo sapiens	140-157
26549279-0	2015	Java project on periodontal diseases: effect of vitamin C/calcium threonate/citrus flavonoids supplementation on periodontal pathogens, CRP and HbA1c.	Flavonoids	83-93	C-reactive protein	Homo sapiens	136-139
25893829-0	2015	Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines.	Flavonoids	48-57	cannabinoid receptor 1	Homo sapiens	84-87
25893829-8	2015	Interestingly, the metabolism of beta-catenin was modified by flavonoid both directly and through activated CB1-R.	Flavonoids	62-71	catenin beta 1	Homo sapiens	33-45
25893829-8	2015	Interestingly, the metabolism of beta-catenin was modified by flavonoid both directly and through activated CB1-R.	Flavonoids	62-71	cannabinoid receptor 1	Homo sapiens	108-113
26439681-6	2015	Flavonoids decreased the level of pAkt and other downstream targets of phosphoinositide-3-kinase/Akt pathway - P-4EBP1 and P-p70S6K.	Flavonoids	0-10	AKT serine/threonine kinase 1	Homo sapiens	35-38
26347569-3	2015	Two chil mutants with a seed colour similar to that of wild-type Arabidopsis have been identified here, but in sharp contrast to the characteristic transparent testa seed phenotype associated with other known flavonoid pathway genes.	Flavonoids	209-218	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	4-8
26347569-8	2015	Moreover, it is demonstrated that CHIL co-expresses, co-localizes, and interacts with TT5 in Arabidopsis for flavonoid production.	Flavonoids	109-118	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	34-38
26347569-8	2015	Moreover, it is demonstrated that CHIL co-expresses, co-localizes, and interacts with TT5 in Arabidopsis for flavonoid production.	Flavonoids	109-118	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	86-89
26347569-9	2015	Based on these genetic and metabolic studies, it is concluded that CHIL functions with TT5 to promote flavonoid production, which is a unique enhancer in the flavonoid pathway.	Flavonoids	102-111	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	67-71
26347569-9	2015	Based on these genetic and metabolic studies, it is concluded that CHIL functions with TT5 to promote flavonoid production, which is a unique enhancer in the flavonoid pathway.	Flavonoids	102-111	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	87-90
26347569-9	2015	Based on these genetic and metabolic studies, it is concluded that CHIL functions with TT5 to promote flavonoid production, which is a unique enhancer in the flavonoid pathway.	Flavonoids	158-167	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	67-71
26347569-9	2015	Based on these genetic and metabolic studies, it is concluded that CHIL functions with TT5 to promote flavonoid production, which is a unique enhancer in the flavonoid pathway.	Flavonoids	158-167	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	87-90
26742315-1	2015	OBJECTIVE: To ascertain if total flavonoids of Guangzao (Fructus Choerospondiatis) (TFFC) extracted from Guangzao (Fructus Choerospondiatis) can inhibit angiotensin II-induced proliferation of cardiac fibroblasts (CFs).	Flavonoids	33-43	angiotensinogen	Rattus norvegicus	153-167
28911482-6	2015	However, the additional attachment of a rhamnosyl glycoside to the flavonoid backbone of teaghrelin-like compounds at C-7 significantly reduced their binding affinity with the ghrelin receptor.	Flavonoids	67-76	growth hormone secretagogue receptor	Homo sapiens	176-192
26320690-4	2015	AIM OF THE STUDY: To evaluate the hepatoprotective activity of total flavonoids (TFs) obtained from C. glandulosum seeds against carbon tetrachloride (CCl4)-induced liver damage in vitro and in vivo.	Flavonoids	69-79	C-C motif chemokine ligand 4	Rattus norvegicus	151-155
26460729-2	2015	Natural flavonoid morin was confirmed to not only inhibit the amyloid formation of hIAPP, but disaggregate its preformed amyloid fibrils.	Flavonoids	8-17	islet amyloid polypeptide	Homo sapiens	83-88
25976993-6	2015	The concentrations of polyphenols and flavonoids showed significant positive correlations with antioxidant activity as measured by DPPH, ABTS(+), and FRAP assays.	Flavonoids	38-48	mechanistic target of rapamycin kinase	Homo sapiens	150-154
26346778-0	2015	G-protein alpha-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana.	Flavonoids	81-90	G protein alpha subunit 1	Arabidopsis thaliana	0-23
26346778-0	2015	G-protein alpha-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana.	Flavonoids	81-90	G protein alpha subunit 1	Arabidopsis thaliana	25-29
26346778-4	2015	We found 394 GPA1-regulated genes spanning 79 biological processes, including biotic and abiotic stresses, development, flavonoid biosynthesis, transcription factors, transporters and nitrate/phosphate responses.	Flavonoids	120-129	G protein alpha subunit 1	Arabidopsis thaliana	13-17
26100136-4	2015	Various flavonoids were used as stimulants to enhance the expression of NKG2D ligands.	Flavonoids	8-18	killer cell lectin like receptor K1	Homo sapiens	72-77
26002966-4	2015	AKR1C35 also differed from AKR1C34 in its high sensitivity to flavonoids, which inhibited competitively with respect to 17beta-estradiol (Ki 0.11-0.69 muM).	Flavonoids	62-72	aldo-keto reductase family 1 member C13-like	Mesocricetus auratus	0-7
26222491-0	2015	Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids.	Flavonoids	114-124	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	18-37
26222491-0	2015	Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids.	Flavonoids	114-124	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	61-67
26222491-11	2015	These results indicate that the CYP2A6.25 mutation confers new substrate specificity towards flavonoids.	Flavonoids	93-103	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	32-38
25708386-0	2015	Biotransformations and biological activities of hop flavonoids.	Flavonoids	52-62	HOP homeobox	Homo sapiens	48-51
25708386-3	2015	In this review we aim to present current knowledge on the biotransformation of flavonoids from hop cones with respect to products, catalysis and conversion.	Flavonoids	79-89	HOP homeobox	Homo sapiens	95-98
25708386-5	2015	A comparative analysis of the biological activities of hop flavonoids and their biotransformation products is described, indicating where further research has potential for applications in the pharmaceutical industry.	Flavonoids	59-69	HOP homeobox	Homo sapiens	55-58
26002966-4	2015	AKR1C35 also differed from AKR1C34 in its high sensitivity to flavonoids, which inhibited competitively with respect to 17beta-estradiol (Ki 0.11-0.69 muM).	Flavonoids	62-72	aldo-keto reductase family 1 member C13	Mesocricetus auratus	27-34
26372946-5	2015	Moreover, the expression of three flavonoid biosynthesis-related structural genes, namely, chalcone synthase (CHS), chalcone isomerase (CHI) and flavonol synthase (FLS) was also higher in the transgenic plants than in the WT plants.	Flavonoids	34-43	chalcone synthase 1	Solanum lycopersicum	91-108
26140983-0	2015	GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity.	Flavonoids	55-64	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	79-82
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	85-88
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-93
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	spleen associated tyrosine kinase	Homo sapiens	95-98
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	105-111
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	mitogen-activated protein kinase 1	Homo sapiens	113-116
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	mitogen-activated protein kinase 8	Homo sapiens	118-121
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Flavonoids	12-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-78
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Flavonoids	12-21	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Flavonoids	12-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Flavonoids	12-21	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
26386394-7	2015	Also, protein level of inducible NO synthase (iNOS) in LPS-activated BV-2 microglia was to some extent more effectively supressed by CPQ than by unmodified flavonoid.	Flavonoids	156-165	nitric oxide synthase 2, inducible	Mus musculus	23-44
26386394-7	2015	Also, protein level of inducible NO synthase (iNOS) in LPS-activated BV-2 microglia was to some extent more effectively supressed by CPQ than by unmodified flavonoid.	Flavonoids	156-165	nitric oxide synthase 2, inducible	Mus musculus	46-50
26276439-1	2015	Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts.	Flavonoids	149-159	aryl hydrocarbon receptor	Homo sapiens	0-25
26276439-1	2015	Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts.	Flavonoids	149-159	aryl hydrocarbon receptor	Homo sapiens	27-30
26140983-7	2015	A homology model (Lyn) was used in our analyses to demonstrate that high-quality predicted kinase structures are suitable for flavonoid computational studies.	Flavonoids	126-135	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
26291333-0	2015	A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.	Flavonoids	58-67	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
26424772-3	2015	Flavocoxid is a flavonoid that induces a balanced inhibition of cyclooxygenase (COX)-1 and COX-2 peroxidase moieties and of 5-lipoxygenase (LOX) and has efficacy in the male genitourinary system.	Flavonoids	16-25	cytochrome c oxidase I, mitochondrial	Mus musculus	64-86
26424772-3	2015	Flavocoxid is a flavonoid that induces a balanced inhibition of cyclooxygenase (COX)-1 and COX-2 peroxidase moieties and of 5-lipoxygenase (LOX) and has efficacy in the male genitourinary system.	Flavonoids	16-25	cytochrome c oxidase II, mitochondrial	Mus musculus	91-96
26424772-3	2015	Flavocoxid is a flavonoid that induces a balanced inhibition of cyclooxygenase (COX)-1 and COX-2 peroxidase moieties and of 5-lipoxygenase (LOX) and has efficacy in the male genitourinary system.	Flavonoids	16-25	arachidonate 5-lipoxygenase	Mus musculus	124-138
26424772-3	2015	Flavocoxid is a flavonoid that induces a balanced inhibition of cyclooxygenase (COX)-1 and COX-2 peroxidase moieties and of 5-lipoxygenase (LOX) and has efficacy in the male genitourinary system.	Flavonoids	16-25	arachidonate 5-lipoxygenase	Mus musculus	140-143
26497596-3	2015	We show that AtMYB12 not only increases the demand of flavonoid biosynthesis but also increases the supply of carbon from primary metabolism, energy and reducing power, which may fuel the shikimate and phenylalanine biosynthetic pathways to supply more aromatic amino acids for secondary metabolism.	Flavonoids	54-63	myb domain protein 12	Arabidopsis thaliana	13-20
26770322-0	2015	Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.	Flavonoids	14-24	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	85-96
26770322-0	2015	Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.	Flavonoids	14-24	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	97-101
26291333-0	2015	A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.	Flavonoids	58-67	ATP binding cassette subfamily B member 1	Homo sapiens	88-92
26291333-1	2015	Flavonoid dimer FD18 is a new class of dimeric P-gp modulator that can reverse cancer drug resistance.	Flavonoids	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	47-51
26403086-1	2015	Myricetin is a flavonoid that has recently been suggested to induce sustained inhibition of proton-coupled folate transporter (PCFT/SLC46A1), which operates for intestinal folate uptake.	Flavonoids	15-24	solute carrier family 46 member 1	Homo sapiens	127-131
26403086-1	2015	Myricetin is a flavonoid that has recently been suggested to induce sustained inhibition of proton-coupled folate transporter (PCFT/SLC46A1), which operates for intestinal folate uptake.	Flavonoids	15-24	solute carrier family 46 member 1	Canis lupus familiaris	132-139
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Flavonoids	28-37	islet amyloid polypeptide	Homo sapiens	66-72
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Flavonoids	28-37	tumor necrosis factor	Homo sapiens	246-255
26242245-6	2015	Our results showed that the flavonoid antioxidant rutin inhibited amylin-induced neurocytotoxicity, decreased the production of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), malondialdehyde (MDA) and pro-inflammatory cytokines TNF-alpha and IL-1beta, attenuated mitochondrial damage and increased the GSH/GSSG ratio.	Flavonoids	28-37	interleukin 1 alpha	Homo sapiens	260-268
26153070-8	2015	These results suggest that, although quercetin at a low dose protects against mHtt-mediated cell death, higher doses are toxic to the cells, clearly demarcating a narrow therapeutic window for this dietary flavonoid.	Flavonoids	206-215	huntingtin	Mus musculus	78-82
25871879-0	2015	Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation.	Flavonoids	0-10	heme oxygenase 1	Mus musculus	89-105
26929573-4	2015	MATERIALS AND METHODS: Protective ability of flavonoid-enriched (FE) fraction of clove was studied against UV-B induced cytotoxicity, anti-oxidant regulation, oxidative DNA damage, intracellular reactive oxygen species (ROS) generation, apoptotic morphological changes, and regulation of heme oxygenase-1 (HO-1) gene through nuclear factor E2-related factor 2 antioxidant response element (Nrf2 ARE) pathway.	Flavonoids	45-54	heme oxygenase 1	Homo sapiens	306-310
26220903-7	2015	The recent discovery of a small BDNF-mimetic, the naturally occurring flavonoid 7,8-dihydroxyflavone (7,8-DHF), may provide an avenue to allow efficient and safe activation of the BDNF pathway in tackling the symptoms of neurodevelopmental disorders.	Flavonoids	70-79	brain derived neurotrophic factor	Homo sapiens	32-36
26220903-7	2015	The recent discovery of a small BDNF-mimetic, the naturally occurring flavonoid 7,8-dihydroxyflavone (7,8-DHF), may provide an avenue to allow efficient and safe activation of the BDNF pathway in tackling the symptoms of neurodevelopmental disorders.	Flavonoids	70-79	brain derived neurotrophic factor	Homo sapiens	180-184
26929573-4	2015	MATERIALS AND METHODS: Protective ability of flavonoid-enriched (FE) fraction of clove was studied against UV-B induced cytotoxicity, anti-oxidant regulation, oxidative DNA damage, intracellular reactive oxygen species (ROS) generation, apoptotic morphological changes, and regulation of heme oxygenase-1 (HO-1) gene through nuclear factor E2-related factor 2 antioxidant response element (Nrf2 ARE) pathway.	Flavonoids	45-54	NFE2 like bZIP transcription factor 2	Homo sapiens	390-394
26413797-5	2015	In this study, the interactions of berry phenolic compounds and citrus flavonoids with the dimerization and transcriptional domains of HNF-1alpha were characterized using the molecular docking program AutoDock Vina.	Flavonoids	71-81	HNF1 homeobox A	Homo sapiens	135-145
26272613-0	2015	Identification of the Flavonoid Luteolin as a Repressor of the Transcription Factor Hepatocyte Nuclear Factor 4alpha.	Flavonoids	22-31	hepatocyte nuclear factor 4 alpha	Homo sapiens	84-116
26272613-2	2015	In the present study, we identified a naturally occurring flavonoid, luteolin, as a repressor of HNF4alpha by screening for effectors of the human microsomal triglyceride transfer protein (MTP) promoter.	Flavonoids	58-67	hepatocyte nuclear factor 4 alpha	Homo sapiens	97-106
26272613-10	2015	These results suggest that the flavonoid luteolin ameliorates an atherogenic lipid profile in vivo that is likely to be mediated through the inactivation of HNF4alpha.	Flavonoids	31-40	hepatocyte nuclear factor 4 alpha	Homo sapiens	157-166
27441214-0	2015	The protective mechanism of Ginkgolides and Ginkgo flavonoids on the TNF-alpha induced apoptosis of rat hippocampal neurons and its mechanisms in vitro.	Flavonoids	51-61	tumor necrosis factor	Rattus norvegicus	69-78
26322379-0	2015	Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids.	Flavonoids	95-105	death associated protein kinase 1	Homo sapiens	49-82
26322379-3	2015	In the present study, we investigated the binding characteristics of 17 natural flavonoids to DAPK1 using a 1-anilinonaphthalene-8-sulfonic acid competitive binding assay and revealed that morin was the strongest binder among the selected compounds.	Flavonoids	80-90	death associated protein kinase 1	Homo sapiens	94-99
26327408-0	2015	GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway.	Flavonoids	23-32	thioredoxin 1	Mus musculus	119-124
27441214-1	2015	OBJECTIVE: To explore the neuroprotective mechanism of Ginkgolides or Ginkgo flavonoids on the TNF-alpha induced apoptosis of cultured rat hippocampal neurons.	Flavonoids	77-87	tumor necrosis factor	Rattus norvegicus	95-104
27441214-9	2015	CONCLUSIONS: Ginkgolides and Ginkgo flavonoids might protect against apoptosis of hippocampal neurons through inhibiting death receptor pathway or mitochondrial pathway under TNF-alpha background.	Flavonoids	36-46	tumor necrosis factor	Rattus norvegicus	175-184
26400326-1	2015	We investigated the effect of flavonoid compounds extracted from species of genus Iris L. on carbon tetrachloride (CCl4)-induced rat liver fibrosis.	Flavonoids	30-39	C-C motif chemokine ligand 4	Rattus norvegicus	115-119
26442036-2	2015	Legumes use signals (flavonoids) to regulate rhizobial nod gene expression during establishment of the legume-rhizobia N2-fixation symbiosis.	Flavonoids	21-31	atrophin 1	Homo sapiens	55-58
26400326-11	2015	Flavonoid compounds extracted from Iris plants showed significant inhibitory effects on CCl4-induced rat liver fibrosis.	Flavonoids	0-9	C-C motif chemokine ligand 4	Rattus norvegicus	88-92
26442064-3	2015	Dihydroflavonol 4-reductase (DFR) is a vital enzyme of the flavonoid pathway which displays major impact on the formation of anthocyanins, flavan 3-ols and flavonols.	Flavonoids	59-68	putative anthocyanidin reductase	Gossypium hirsutum	0-27
26442064-3	2015	Dihydroflavonol 4-reductase (DFR) is a vital enzyme of the flavonoid pathway which displays major impact on the formation of anthocyanins, flavan 3-ols and flavonols.	Flavonoids	59-68	putative anthocyanidin reductase	Gossypium hirsutum	29-32
26196400-4	2015	Our previous studies showed that the flavonoid component from the seeds of Astragalus complanatus (FAC) is mainly an active constituent and has the hepatoprotective effect, anti-liver fibrosis, and anti-tumor and immune enhancement.	Flavonoids	37-46	FA complementation group C	Homo sapiens	99-102
26264830-2	2015	In B. napus, some flavonoid structural genes have been identified, such as, BnF3H-1, BnCHS, and BnC4H-1.	Flavonoids	18-27	naringenin,2-oxoglutarate 3-dioxygenase	Brassica napus	76-83
26341899-6	2015	PFT1 was also required for the expression of several glucose-induced genes, including those encoding cell wall components and enzymes, regulatory and enzymatic components of anthocyanin biosynthesis, and flavonoid and glucosinolate biosynthetic pathways.	Flavonoids	204-213	phytochrome and flowering time regulatory protein (PFT1)	Arabidopsis thaliana	0-4
26116387-7	2015	The presence of flavonoids, which reduce active catalase intermediate, Compound I to inactive Compound II have not influenced the kinetics of HOCl-induced heme modification.	Flavonoids	16-26	catalase	Homo sapiens	48-56
26404256-1	2015	7,8-dihydroxyflavone (7,8-DHF) is a TrkB receptor agonist, and treatment with this flavonoid derivative brings about an enhanced TrkB phosphorylation and promotes downstream cellular signalling.	Flavonoids	83-92	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	36-40
26404256-1	2015	7,8-dihydroxyflavone (7,8-DHF) is a TrkB receptor agonist, and treatment with this flavonoid derivative brings about an enhanced TrkB phosphorylation and promotes downstream cellular signalling.	Flavonoids	83-92	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	129-133
25999161-5	2015	RESULTS: The dimeric spiro-flavonoid 2""-hydroxygenkwanol A, member of a relatively recently discovered class of flavonoids containing a spirane C-atom, has been identified as possible PARP-1 inhibitor.	Flavonoids	113-123	poly(ADP-ribose) polymerase 1	Homo sapiens	185-191
26468028-1	2015	An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-gamma and IL-2 by ConA-stimulated mononuclear cells.	Flavonoids	54-66	interferon gamma	Homo sapiens	101-110
26468028-1	2015	An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-gamma and IL-2 by ConA-stimulated mononuclear cells.	Flavonoids	54-66	interleukin 2	Homo sapiens	115-119
26054747-2	2015	Dihydromyricetin (DHM), a natural flavonoid, exerts its activities through PGC-1alpha activation.	Flavonoids	34-43	PPARG coactivator 1 alpha	Homo sapiens	75-85
28454959-0	2015	Mode of pancreatic lipase inhibition activity in vitro by some flavonoids and non-flavonoid polyphenols.	Flavonoids	63-73	pancreatic lipase	Homo sapiens	8-25
28454959-0	2015	Mode of pancreatic lipase inhibition activity in vitro by some flavonoids and non-flavonoid polyphenols.	Flavonoids	63-72	pancreatic lipase	Homo sapiens	8-25
28454959-4	2015	To elucidate the kinetic mode of PL inhibition, some selected flavonoid and non-flavonoid polyphenol standards were first screened for their lipase inhibition potency by their half maximal inhibitory concentration (IC50) followed by inhibition kinetic analysis.	Flavonoids	62-71	pancreatic lipase	Homo sapiens	33-35
28454959-4	2015	To elucidate the kinetic mode of PL inhibition, some selected flavonoid and non-flavonoid polyphenol standards were first screened for their lipase inhibition potency by their half maximal inhibitory concentration (IC50) followed by inhibition kinetic analysis.	Flavonoids	80-89	pancreatic lipase	Homo sapiens	33-35
26116387-0	2015	Do pH and flavonoids influence hypochlorous acid-induced catalase inhibition and heme modification?	Flavonoids	10-20	catalase	Homo sapiens	57-65
25981047-0	2015	Constitutive expression of Arabidopsis MYB transcription factor, AtMYB11, in tobacco modulates flavonoid biosynthesis in favor of flavonol accumulation.	Flavonoids	95-104	myb domain protein 11	Arabidopsis thaliana	65-72
26116024-0	2015	AtROS1 overexpression provides evidence for epigenetic regulation of genes encoding enzymes of flavonoid biosynthesis and antioxidant pathways during salt stress in transgenic tobacco.	Flavonoids	95-104	demeter-like 1	Arabidopsis thaliana	0-6
26116024-8	2015	Transgenic tobacco overexpressing AtROS1 showed tolerance to salt stress that could have been due to the higher expression levels of the genes encoding enzymes of the flavonoid biosynthetic and antioxidant pathways.	Flavonoids	167-176	demeter-like 1	Arabidopsis thaliana	34-40
26594765-3	2015	All flavonoids and coumarins showed significant alpha-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.	Flavonoids	4-14	sucrase-isomaltase	Homo sapiens	48-65
26408884-3	2015	To explore mechanism of the association of flavonoids in obesity and obesity associated protein (FTO), molecular docking studies were done for FTO with flavonoids, with orlistat (antiobesity drug) as a control.	Flavonoids	43-53	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	97-100
26408884-3	2015	To explore mechanism of the association of flavonoids in obesity and obesity associated protein (FTO), molecular docking studies were done for FTO with flavonoids, with orlistat (antiobesity drug) as a control.	Flavonoids	43-53	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	143-146
26408884-3	2015	To explore mechanism of the association of flavonoids in obesity and obesity associated protein (FTO), molecular docking studies were done for FTO with flavonoids, with orlistat (antiobesity drug) as a control.	Flavonoids	152-162	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	143-146
26408884-8	2015	This study concludes that flavonoids primarily, quercetin ameliorates obesity by establishing a physical interaction with FTO.	Flavonoids	26-36	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	122-125
26115549-1	2015	MYB proteins are involved in many significant physiological and biochemical processes, including regulation of primary and secondary metabolism, flavonoid biosynthesis, response to various biotic and abiotic stresses, hormone synthesis and signal transduction.	Flavonoids	145-154	uncharacterized protein LOC107775040	Nicotiana tabacum	0-3
26104578-2	2015	The aim of the present study is to understand the efficacy of a flavonoid myricetin for the first time in inhibiting the downstream target p21 activated kinase 1 (PAK1) of Ras signaling pathway in hepatocellular carcinoma.	Flavonoids	64-73	p21 (RAC1) activated kinase 1	Homo sapiens	139-161
26104578-2	2015	The aim of the present study is to understand the efficacy of a flavonoid myricetin for the first time in inhibiting the downstream target p21 activated kinase 1 (PAK1) of Ras signaling pathway in hepatocellular carcinoma.	Flavonoids	64-73	p21 (RAC1) activated kinase 1	Homo sapiens	163-167
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Flavonoids	19-28	presenilin 1	Mus musculus	52-64
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Flavonoids	19-28	amyloid beta (A4) precursor protein	Mus musculus	80-85
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Flavonoids	19-28	protein phosphatase 1, regulatory subunit 15A	Mus musculus	144-198
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Flavonoids	19-28	eukaryotic translation initiation factor 2A	Mus musculus	215-224
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Flavonoids	19-28	activating transcription factor 4	Mus musculus	265-269
26070140-10	2015	However, the enzyme kinetics and gene expression of the willow PAL genes differed slightly, with willow PAL2 being more widely expressed than its poplar orthologues implying a wider role for PALs in the production of flavonoids, condensed tannins, benzenoids, and phenolic glycosides, in willow.	Flavonoids	217-227	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	63-66
25981047-1	2015	KEY MESSAGE: Heterologous expression of AtMYB11 , a flavonol-specific transcription factor from Arabidopsis , in tobacco modulates flavonoid biosynthesis, however, with a lower efficiency as compared to its paralogs AtMYB12 and AtMYB111.	Flavonoids	131-140	myb domain protein 11	Arabidopsis thaliana	40-47
26205169-2	2015	Recent studies support and further extend previous hypotheses indicating that vacuolar sequestration of flavonoids involves vesicle trafficking, membrane transporters, and glutathione S-transferase (GST).	Flavonoids	104-114	glutathione S-transferase kappa 1	Homo sapiens	172-197
26327560-0	2015	A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.	Flavonoids	15-24	angiotensinogen	Rattus norvegicus	51-65
26205169-2	2015	Recent studies support and further extend previous hypotheses indicating that vacuolar sequestration of flavonoids involves vesicle trafficking, membrane transporters, and glutathione S-transferase (GST).	Flavonoids	104-114	glutathione S-transferase kappa 1	Homo sapiens	199-202
26004313-5	2015	We previously determined that G. uralensis flavonoids are the key active compounds responsible for ASHMITM suppression of Th2 mediated inflammation.	Flavonoids	43-53	heart and neural crest derivatives expressed 2	Mus musculus	122-125
26093063-7	2015	These flavonoids inhibited NF-kappaB p65 activity via the IRAK1/IkappaBalpha signaling pathway and expression of IkappaBzeta.	Flavonoids	6-16	synaptotagmin 1	Rattus norvegicus	37-40
26093063-7	2015	These flavonoids inhibited NF-kappaB p65 activity via the IRAK1/IkappaBalpha signaling pathway and expression of IkappaBzeta.	Flavonoids	6-16	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	58-63
26093063-7	2015	These flavonoids inhibited NF-kappaB p65 activity via the IRAK1/IkappaBalpha signaling pathway and expression of IkappaBzeta.	Flavonoids	6-16	NFKB inhibitor alpha	Rattus norvegicus	64-76
26093063-7	2015	These flavonoids inhibited NF-kappaB p65 activity via the IRAK1/IkappaBalpha signaling pathway and expression of IkappaBzeta.	Flavonoids	6-16	NFKB inhibitor zeta	Rattus norvegicus	113-124
26093063-11	2015	This study is the first to show that certain flavonoids are inhibitors of SASP production, partially related to NF-kappaB p65 and IkappaBzeta signaling pathway, and may effectively protect or alleviate chronic low-grade inflammation in degenerative diseases such as cardiovascular diseases and late-stage cancer.	Flavonoids	45-55	synaptotagmin 1	Rattus norvegicus	122-125
26093063-11	2015	This study is the first to show that certain flavonoids are inhibitors of SASP production, partially related to NF-kappaB p65 and IkappaBzeta signaling pathway, and may effectively protect or alleviate chronic low-grade inflammation in degenerative diseases such as cardiovascular diseases and late-stage cancer.	Flavonoids	45-55	NFKB inhibitor zeta	Rattus norvegicus	130-141
29124175-3	2015	Methods: Interaction of flavonoids with TTR and effect on TTR stability were assessed through binding assays and isoelectric focusing in polyacrylamide gel.	Flavonoids	24-34	transthyretin	Homo sapiens	40-43
29124175-5	2015	Results: Tested flavonoids bound to TTR and stabilized the TTR tetramer, with different potencies.	Flavonoids	16-26	transthyretin	Homo sapiens	36-39
29124175-5	2015	Results: Tested flavonoids bound to TTR and stabilized the TTR tetramer, with different potencies.	Flavonoids	16-26	transthyretin	Homo sapiens	59-62
29124175-6	2015	The flavonoids also inhibited in vitro formation of TTR small oligomeric species and in cell culture inhibited pathways involving caspase-3 activation and ER stress that are induced by TTR oligomers.	Flavonoids	4-14	transthyretin	Homo sapiens	52-55
29124175-6	2015	The flavonoids also inhibited in vitro formation of TTR small oligomeric species and in cell culture inhibited pathways involving caspase-3 activation and ER stress that are induced by TTR oligomers.	Flavonoids	4-14	caspase 3	Homo sapiens	130-139
29124175-6	2015	The flavonoids also inhibited in vitro formation of TTR small oligomeric species and in cell culture inhibited pathways involving caspase-3 activation and ER stress that are induced by TTR oligomers.	Flavonoids	4-14	transthyretin	Homo sapiens	185-188
29124175-8	2015	Conclusions: Our results highlight the presence of gallate ester moiety as key structural feature of flavonoids in chemical chaperoning of TTR aggregation.	Flavonoids	101-111	transthyretin	Homo sapiens	139-142
29124175-9	2015	Upon binding to the native tetramer, gallated flavonoids redirect the TTR amyloidogenic pathway into unstructured nontoxic aggregation assemblies more efficiently than their non-gallated forms.	Flavonoids	46-56	transthyretin	Homo sapiens	70-73
25881548-0	2015	The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.	Flavonoids	103-112	mitogen-activated protein kinase 8	Homo sapiens	70-73
25752620-1	2015	Cyanidin-3-O-glucoside (C3G), an anthocyanin belonging to the flavonoid family and commonly present in food and vegetables in human diet, has exhibited anti-inflammatory and anti-oxidant effects.	Flavonoids	62-71	Rap guanine nucleotide exchange factor 1	Homo sapiens	24-27
26275107-3	2015	Crystallographic analysis of Pim-1 bound to hispidulin reveals a binding mode distinct from that of quercetin, suggesting that the binding potency of flavonoids is determined by their hydrogen-bonding interactions with the hinge region of the kinase.	Flavonoids	150-160	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	29-34
29124175-0	2015	Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors.	Flavonoids	38-48	transthyretin	Homo sapiens	0-13
29124175-2	2015	To investigate structure-activity relationships relevant for the interaction of flavonoids with transthyretin (TTR), the protein associated with familial amyloid polyneuropathy (FAP), we compared the effects of major tea catechins and their larger polymers theaflavins, side-by-side, on TTR amyloid formation process.	Flavonoids	80-90	transthyretin	Homo sapiens	96-109
29124175-2	2015	To investigate structure-activity relationships relevant for the interaction of flavonoids with transthyretin (TTR), the protein associated with familial amyloid polyneuropathy (FAP), we compared the effects of major tea catechins and their larger polymers theaflavins, side-by-side, on TTR amyloid formation process.	Flavonoids	80-90	transthyretin	Homo sapiens	111-114
26018917-0	2015	Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human beta-Glucuronidase - In Vitro and In Silico Analyses.	Flavonoids	37-46	glucuronidase beta	Homo sapiens	69-87
25864533-8	2015	CONCLUSIONS: Our findings confirm that morin is non-toxic to rat intestinal epithelium against verapamil demonstrating the potential use of bioflavonoid as safe and novel pharmaceutical adjuvant as P-gp inhibitor.	Flavonoids	140-152	phosphoglycolate phosphatase	Rattus norvegicus	198-202
25936595-5	2015	The flavonoids also significantly inhibited the transcriptional regulators of adipogenesis, including peroxisome proliferator-activated receptor-gamma, CAAT/enhancer binding protein-alpha and sterol regulatory element binding protein (SREBP)-1c, compared with the control cells.	Flavonoids	4-14	peroxisome proliferator activated receptor gamma	Mus musculus	102-150
25936595-5	2015	The flavonoids also significantly inhibited the transcriptional regulators of adipogenesis, including peroxisome proliferator-activated receptor-gamma, CAAT/enhancer binding protein-alpha and sterol regulatory element binding protein (SREBP)-1c, compared with the control cells.	Flavonoids	4-14	sterol regulatory element binding transcription factor 1	Mus musculus	192-244
25936595-7	2015	Notably, the cells treated with the flavonoids demonstrated increased expression levels of the insulin-induced genes, insig-1 and insig-2, which may have inhibited the activation of the adipogenic transcription factor, SREBP, eventually leading to the inhibition of adipogenesis.	Flavonoids	36-46	insulin induced gene 1	Mus musculus	118-125
25936595-7	2015	Notably, the cells treated with the flavonoids demonstrated increased expression levels of the insulin-induced genes, insig-1 and insig-2, which may have inhibited the activation of the adipogenic transcription factor, SREBP, eventually leading to the inhibition of adipogenesis.	Flavonoids	36-46	insulin induced gene 2	Mus musculus	130-137
25936595-8	2015	Taken together, these results revealed that the flavonoids from TA possessed an inhibitory effect on adipogenesis through downregulation of adipogenic transcription factors and genes associated with lipid metabolism, and the upregulation of insig 1 and 2, suggesting that the flavonoids from TA may be potential therapeutic agents for the prevention and treatment of obesity.	Flavonoids	48-58	insulin induced gene 1	Mus musculus	241-254
25688010-1	2015	Using whole-cell patch-clamp technique, we investigated influence of selected compounds from groups of prenylated chalcones and flavonoids: xanthohumol and isoxanthohumol on the activity of Kv1.3 channels in human leukemic Jurkat T cells.	Flavonoids	128-138	potassium voltage-gated channel subfamily A member 3	Homo sapiens	190-195
25688010-9	2015	These results may confirm our earlier hypothesis that the presence of a prenyl group in a molecule is a factor that facilitates the inhibition of Kv1.3 channels by compounds from the groups of flavonoids and chalcones.	Flavonoids	193-203	potassium voltage-gated channel subfamily A member 3	Homo sapiens	146-151
26677707-0	2015	[Inhibitory effect of flavonoids from Glycyrrhiza uralensis on expressions of TGF-beta1 and Caspase-3 in thioacetamide-induced hepatic fibrosis in rats].	Flavonoids	22-32	transforming growth factor, beta 1	Rattus norvegicus	78-87
26677707-0	2015	[Inhibitory effect of flavonoids from Glycyrrhiza uralensis on expressions of TGF-beta1 and Caspase-3 in thioacetamide-induced hepatic fibrosis in rats].	Flavonoids	22-32	caspase 3	Rattus norvegicus	92-101
26677707-1	2015	OBJECTIVE: To study the inhibitory effect of flavonoids from Glycyrrhiza uralensis on thioacetamide-induced chonic hepatic fibrosis in rats and the effect on the protein expressions of transforming growth factor-beta1 (TGF-beta1) and Caspase-3 in livers.	Flavonoids	45-55	transforming growth factor, beta 1	Rattus norvegicus	219-228
26677707-1	2015	OBJECTIVE: To study the inhibitory effect of flavonoids from Glycyrrhiza uralensis on thioacetamide-induced chonic hepatic fibrosis in rats and the effect on the protein expressions of transforming growth factor-beta1 (TGF-beta1) and Caspase-3 in livers.	Flavonoids	45-55	caspase 3	Rattus norvegicus	234-243
26677707-10	2015	RESULT: Compared with the model group, flavonoids can protect the integrity of the structure of liver tissues, significantly reduce the hepatic cell degeneration and necrosis and the proliferation of fibrous tissues, notably reduce the serum AST, ALT, ALP and HA and HYP in hepatic tissues and down-regulate the protein expressions of liver TGF-beta1 and Caspase-3 and the mRNA expression of TGF-beta1 in hepatic tissues.	Flavonoids	39-49	transforming growth factor, beta 1	Rattus norvegicus	341-350
26677707-10	2015	RESULT: Compared with the model group, flavonoids can protect the integrity of the structure of liver tissues, significantly reduce the hepatic cell degeneration and necrosis and the proliferation of fibrous tissues, notably reduce the serum AST, ALT, ALP and HA and HYP in hepatic tissues and down-regulate the protein expressions of liver TGF-beta1 and Caspase-3 and the mRNA expression of TGF-beta1 in hepatic tissues.	Flavonoids	39-49	caspase 3	Rattus norvegicus	355-364
26677707-10	2015	RESULT: Compared with the model group, flavonoids can protect the integrity of the structure of liver tissues, significantly reduce the hepatic cell degeneration and necrosis and the proliferation of fibrous tissues, notably reduce the serum AST, ALT, ALP and HA and HYP in hepatic tissues and down-regulate the protein expressions of liver TGF-beta1 and Caspase-3 and the mRNA expression of TGF-beta1 in hepatic tissues.	Flavonoids	39-49	transforming growth factor, beta 1	Rattus norvegicus	392-401
26197325-9	2015	Chromatographic analyses of thrombin samples incubated with these flavonoids demonstrated the chemical modification of this enzyme, suggesting that the MeOH extract contained other compounds that both induced structural changes in thrombin and diminished its activity.	Flavonoids	66-76	coagulation factor II, thrombin	Homo sapiens	28-36
26206248-0	2015	AtMYB12 expression in tomato leads to large scale differential modulation in transcriptome and flavonoid content in leaf and fruit tissues.	Flavonoids	95-104	myb domain protein 12	Arabidopsis thaliana	0-7
26197325-9	2015	Chromatographic analyses of thrombin samples incubated with these flavonoids demonstrated the chemical modification of this enzyme, suggesting that the MeOH extract contained other compounds that both induced structural changes in thrombin and diminished its activity.	Flavonoids	66-76	coagulation factor II, thrombin	Homo sapiens	231-239
26197325-8	2015	Two glycosylated flavonoids in this partition were identified as the most potent inhibitors of human thrombin activity, namely quercetin-3-O-arabinoside (QAra) and quercetin-3-O-rhamnoside (Qn).	Flavonoids	17-27	coagulation factor II, thrombin	Homo sapiens	101-109
26066637-0	2015	Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling.	Flavonoids	115-125	ATP binding cassette subfamily C member 4	Homo sapiens	24-65
26192267-0	2015	The Balance of Expression of Dihydroflavonol 4-reductase and Flavonol Synthase Regulates Flavonoid Biosynthesis and Red Foliage Coloration in Crabapples.	Flavonoids	89-98	bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase	Malus domestica	29-56
26192267-0	2015	The Balance of Expression of Dihydroflavonol 4-reductase and Flavonol Synthase Regulates Flavonoid Biosynthesis and Red Foliage Coloration in Crabapples.	Flavonoids	89-98	flavonol synthase/flavanone 3-hydroxylase	Malus domestica	61-78
26022844-0	2015	Discovery of xanthine oxidase inhibitors and/or alpha-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.	Flavonoids	121-130	xanthine dehydrogenase	Mus musculus	13-29
26022844-0	2015	Discovery of xanthine oxidase inhibitors and/or alpha-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.	Flavonoids	121-130	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
26066637-0	2015	Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling.	Flavonoids	115-125	ATP binding cassette subfamily C member 4	Homo sapiens	67-71
26066637-0	2015	Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling.	Flavonoids	115-125	ATP binding cassette subfamily C member 4	Homo sapiens	72-77
26066637-0	2015	Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling.	Flavonoids	115-125	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	129-135
26022682-10	2015	Hepatic expression of Cyp2b9 was strongly downregulated by all flavonoids.	Flavonoids	63-73	cytochrome P450, family 2, subfamily b, polypeptide 9	Mus musculus	22-28
25918240-6	2015	The enzyme kinetics of "wild-type" canine cbr1 (cbr1 D218) and a variant isoform (cbr1 V218) were characterized with the substrates daunorubicin and menadione, as well as the flavonoid inhibitor rutin.	Flavonoids	175-184	carbonyl reductase [NADPH] 1	Canis lupus familiaris	42-46
25998143-4	2015	According to previous screening, tangeretin, a polymethoxylated flavonoid from citrus fruits was selected as a Notch-1 inhibitor.	Flavonoids	64-73	notch 1	Mus musculus	111-118
25931267-1	2015	In this study, the effect of Chrysin (5,7-dihydroxyflavone), an important member of the flavonoid family, on memory impairment, oxidative stress and BDNF reduction generated by aging in mice were investigated.	Flavonoids	88-97	brain derived neurotrophic factor	Mus musculus	149-153
25931267-10	2015	These results demonstrated that flavonoid Chrysin, an antioxidant compound, was able to prevent age-associated memory probably by their free radical scavenger action and modulation of BDNF production.	Flavonoids	32-41	brain derived neurotrophic factor	Mus musculus	184-188
26061016-5	2015	We here found that quercetin, a flavonoid present in fruits and vegetables, time- and concentration-dependently decreases claudin-2 expression in lung adenocarcinoma A549 cells.	Flavonoids	32-41	claudin 2	Homo sapiens	122-131
29124159-0	2015	Functional identification of organic cation transporter 1 as an atenolol transporter sensitive to flavonoids.	Flavonoids	98-108	solute carrier family 22 member 1	Homo sapiens	29-57
26132857-9	2015	This article summarizes most studied subclasses of polyphenols including flavonoids, hydroxycinnamic acids, hydroxybenzoic acids and lignans with pancreatic lipase inhibitory effects.	Flavonoids	73-83	pancreatic lipase	Homo sapiens	146-163
26351171-1	2015	4-coumaric acid: coenzyme A ligase (4CL) gene is one of the key genes involved in the regulation of lignin metabolism and the synthesis of flavonoid and other secondary metabolites in plant, while the synthesized and polymerized lignin is deposited in cell walls and leads to thickening of secondary walls in some parenchyma cells and formation of stone cells.	Flavonoids	139-148	4-coumarate--CoA ligase 1	Pyrus x bretschneideri	0-34
26351171-1	2015	4-coumaric acid: coenzyme A ligase (4CL) gene is one of the key genes involved in the regulation of lignin metabolism and the synthesis of flavonoid and other secondary metabolites in plant, while the synthesized and polymerized lignin is deposited in cell walls and leads to thickening of secondary walls in some parenchyma cells and formation of stone cells.	Flavonoids	139-148	4-coumarate--CoA ligase 1	Pyrus x bretschneideri	36-39
25978649-5	2015	Apigenin, a common plant food flavonoid, was shown to modulate the nuclear translocation of SREBP-2 in the hepatic cells WRL-68 in the present study.	Flavonoids	30-39	sterol regulatory element binding transcription factor 2	Homo sapiens	92-99
26098744-1	2015	This study selectively acylated the primary hydroxyl groups on flavonoids in antioxidant of bamboo leaves (AOB) using lauric acid with Candida antarctica lipase B in tert-amyl-alcohol.	Flavonoids	63-73	lipase	Solanum tuberosum	154-160
26075008-0	2015	Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid.	Flavonoids	105-114	carbamoyl-phosphate synthetase 1	Mus musculus	32-64
26075008-0	2015	Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid.	Flavonoids	105-114	carbamoyl-phosphate synthetase 1	Mus musculus	66-70
26042900-4	2015	Glycosylated flavonoids, such as quercetin-3-O-sophoroside, are the physiological ligands of Bet v 1, and here we found that three isoforms differing in their allergenic potential also show an individual, highly specific binding behaviour for the different ligands.	Flavonoids	13-23	delta/notch like EGF repeat containing	Homo sapiens	93-96
25911954-1	2015	Herein, atom-based 3D-QSAR analysis was performed using receptor-guided alignment of 46 flavonoid inhibitors of aldose reductase (ALR2) enzyme.	Flavonoids	88-97	aldo-keto reductase family 1 member B	Homo sapiens	112-128
25626735-3	2015	A known prominent inhibitor of IKKbeta/NF-kappaB signaling is the dietary flavonoid butein.	Flavonoids	74-83	inhibitor of kappaB kinase beta	Mus musculus	31-38
25840992-0	2015	Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.	Flavonoids	19-28	heat shock factor 1	Mus musculus	78-82
25840992-4	2015	We performed cell-based screening with a natural compound collection and identified fisetin, a dietary flavonoid, as a HSF1 inhibitor.	Flavonoids	103-112	heat shock factor 1	Mus musculus	119-123
25911954-1	2015	Herein, atom-based 3D-QSAR analysis was performed using receptor-guided alignment of 46 flavonoid inhibitors of aldose reductase (ALR2) enzyme.	Flavonoids	88-97	aldo-keto reductase family 1 member B	Homo sapiens	130-134
24976450-3	2015	Our previous studies have demonstrated that wogonin (a bioflavonoid isolated from the traditional Chinese medicine of Huang-Qin) possesses the anti-metastatic and anti-inflammatory activity, but we have little idea about its efficacy on inflammatory-induced tumor metastasis and the mechanism underlying it.	Flavonoids	55-67	forkhead box G1	Homo sapiens	124-127
26046972-5	2015	Bioactivity evaluations using poly(ADP-ribose) polymerase (PARP) ELISA showed that the synthetic flavonoids were less effective in inhibiting PARP than the natural flavonoids, where PARP inhibitory effects decreased with glycosylation of flavonoids.	Flavonoids	97-107	poly [ADP-ribose] polymerase 1	Cricetulus griseus	30-57
25801720-0	2015	Flavonoid metabolites reduce tumor necrosis factor-alpha secretion to a greater extent than their precursor compounds in human THP-1 monocytes.	Flavonoids	0-9	tumor necrosis factor	Homo sapiens	29-56
25801720-0	2015	Flavonoid metabolites reduce tumor necrosis factor-alpha secretion to a greater extent than their precursor compounds in human THP-1 monocytes.	Flavonoids	0-9	GLI family zinc finger 2	Homo sapiens	127-132
23416881-6	2015	It is suggested that LPME effectively protects the liver against the CCl4-induced oxidative damage in rats, possibly through antioxidant and/or free radical scavenging effects of flavonoids and phenolic compounds in the extract.	Flavonoids	179-189	C-C motif chemokine ligand 4	Rattus norvegicus	69-73
25809288-0	2015	The Flavonoid 7,4"-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-kappaB, STAT6, and HDAC2.	Flavonoids	4-13	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	45-51
25809288-5	2015	The aim of the present study was to determine if the G. uralensis flavonoid 7,4"-dihydroxyflavone (7,4"-DHF) inhibits MUC5AC gene expression, mucus production, and secretion, and if so, to elucidate the mechanism of this inhibition.	Flavonoids	66-75	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	118-124
26046972-5	2015	Bioactivity evaluations using poly(ADP-ribose) polymerase (PARP) ELISA showed that the synthetic flavonoids were less effective in inhibiting PARP than the natural flavonoids, where PARP inhibitory effects decreased with glycosylation of flavonoids.	Flavonoids	97-107	poly [ADP-ribose] polymerase 1	Cricetulus griseus	59-63
26046972-5	2015	Bioactivity evaluations using poly(ADP-ribose) polymerase (PARP) ELISA showed that the synthetic flavonoids were less effective in inhibiting PARP than the natural flavonoids, where PARP inhibitory effects decreased with glycosylation of flavonoids.	Flavonoids	97-107	poly [ADP-ribose] polymerase 1	Cricetulus griseus	142-146
26046972-5	2015	Bioactivity evaluations using poly(ADP-ribose) polymerase (PARP) ELISA showed that the synthetic flavonoids were less effective in inhibiting PARP than the natural flavonoids, where PARP inhibitory effects decreased with glycosylation of flavonoids.	Flavonoids	97-107	poly [ADP-ribose] polymerase 1	Cricetulus griseus	142-146
26046972-5	2015	Bioactivity evaluations using poly(ADP-ribose) polymerase (PARP) ELISA showed that the synthetic flavonoids were less effective in inhibiting PARP than the natural flavonoids, where PARP inhibitory effects decreased with glycosylation of flavonoids.	Flavonoids	164-174	poly [ADP-ribose] polymerase 1	Cricetulus griseus	59-63
26046972-5	2015	Bioactivity evaluations using poly(ADP-ribose) polymerase (PARP) ELISA showed that the synthetic flavonoids were less effective in inhibiting PARP than the natural flavonoids, where PARP inhibitory effects decreased with glycosylation of flavonoids.	Flavonoids	164-174	poly [ADP-ribose] polymerase 1	Cricetulus griseus	59-63
25779965-3	2015	In pursuit to find a potent inhibitor of BACE1, we identified galangin, a natural flavonoid, had a significant lowering effect on Abeta levels.	Flavonoids	82-91	beta-secretase 1	Homo sapiens	41-46
25779965-3	2015	In pursuit to find a potent inhibitor of BACE1, we identified galangin, a natural flavonoid, had a significant lowering effect on Abeta levels.	Flavonoids	82-91	amyloid beta precursor protein	Homo sapiens	130-135
25661191-3	2015	We evaluated the action of a flavonoid derivative 7,8-dihydroxyflavone (7,8-DHF), a BDNF receptor (TrkB) agonist with the pharmacological profile congruent for potential human therapies.	Flavonoids	29-38	brain derived neurotrophic factor	Homo sapiens	84-88
25907027-0	2015	Number of Hydroxyl Groups on the B-Ring of Flavonoids Affects Their Antioxidant Activity and Interaction with Phorbol Ester Binding Site of PKCdelta C1B Domain: In Vitro and in Silico Studies.	Flavonoids	43-53	protein kinase C delta	Homo sapiens	140-148
25907027-3	2015	In vitro assays, including DPPH scavenging activity, ROS quantification by flow cytometer, and proteins immunoblotting, and in silico analysis by molecular docking between the flavonoids and C1B domain of PKCdelta phorbol ester binding site were both used to complete this study.	Flavonoids	176-186	protein kinase C delta	Homo sapiens	205-213
25999863-1	2015	Xanthohumol is the principal prenylated flavonoid of the female inflorescences of the hop plant.	Flavonoids	40-49	HOP homeobox	Homo sapiens	86-89
26467143-7	2015	In the last section, the results of studies performed in our Laboratory of Bioelectricity on the influence of selected biologically active plant-derived compounds from the groups of flavonoids and stilbenes and their natural and synthetic derivatives on the activity of Kv1.3 channels in normal and cancer cells are reviewed.	Flavonoids	182-192	potassium voltage-gated channel subfamily A member 3	Homo sapiens	270-275
25661191-0	2015	Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.	Flavonoids	0-9	neurotrophic receptor tyrosine kinase 2	Homo sapiens	58-62
25661191-3	2015	We evaluated the action of a flavonoid derivative 7,8-dihydroxyflavone (7,8-DHF), a BDNF receptor (TrkB) agonist with the pharmacological profile congruent for potential human therapies.	Flavonoids	29-38	neurotrophic receptor tyrosine kinase 2	Homo sapiens	99-103
25954125-1	2015	The present study showed that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibited lipopolysaccharide (LPS)-induced morphological changes in the mouse RAW264.7 macrophage cell line.	Flavonoids	56-65	toll-like receptor 4	Mus musculus	143-146
25738754-3	2015	This study is also the first to reveal that tricetin (TCN), a flavonoid derivative found in Myrtaceae pollen and Eucalyptus honey, was able to reverse BaP-mediated bone resorption activity of lung cancer cells.	Flavonoids	62-71	prohibitin 2	Homo sapiens	151-154
25820747-0	2015	The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells.	Flavonoids	37-46	tumor protein p53 inducible protein 3	Homo sapiens	4-24
25820747-2	2015	Here we investigated the potential mechanism that p53-inducible gene 3 (PIG3), a NADPH:quinone oxidoreductase, mediated the prooxidant cytotoxicity of flavonoids on human hepatoma HepG2 cells.	Flavonoids	151-161	tumor protein p53 inducible protein 3	Homo sapiens	50-70
25820747-2	2015	Here we investigated the potential mechanism that p53-inducible gene 3 (PIG3), a NADPH:quinone oxidoreductase, mediated the prooxidant cytotoxicity of flavonoids on human hepatoma HepG2 cells.	Flavonoids	151-161	tumor protein p53 inducible protein 3	Homo sapiens	72-76
25820747-4	2015	We also found that expression of PIG3 was increased markedly in HepG2 cells treated with flavonoids at both mRNA and protein levels, which was accompanied by increased intracellular ROS production and a decreased mitochondrial membrane potential (DeltaPsim).	Flavonoids	89-99	tumor protein p53 inducible protein 3	Homo sapiens	33-37
25820747-6	2015	Western blotting indicated that flavonoids increased cytochrome c release, upregulated the ratio of Bax/Bcl-2, and activated the caspases-9 and -3.	Flavonoids	32-42	cytochrome c, somatic	Homo sapiens	53-65
25820747-6	2015	Western blotting indicated that flavonoids increased cytochrome c release, upregulated the ratio of Bax/Bcl-2, and activated the caspases-9 and -3.	Flavonoids	32-42	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103
25820747-6	2015	Western blotting indicated that flavonoids increased cytochrome c release, upregulated the ratio of Bax/Bcl-2, and activated the caspases-9 and -3.	Flavonoids	32-42	BCL2 apoptosis regulator	Homo sapiens	104-109
25820747-6	2015	Western blotting indicated that flavonoids increased cytochrome c release, upregulated the ratio of Bax/Bcl-2, and activated the caspases-9 and -3.	Flavonoids	32-42	caspase 9	Homo sapiens	129-146
25820747-8	2015	These results suggest that PIG3 plays an important role in regulating the prooxidant activity and apoptosis-inducing action of flavonoids on HepG2 cells though the ROS-triggered mitochondrial apoptotic pathway.	Flavonoids	127-137	tumor protein p53 inducible protein 3	Homo sapiens	27-31
25684704-6	2015	The flavonoids, quercetin, and kaempferol showed potent (IC50 values less than 100 muM) inhibition of CYP3A4 activity, whereas quercetin alone showed potent inhibition of CYP2D6 activity in HLM.	Flavonoids	4-14	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	102-108
25987215-2	2015	Our previous report demonstrated that certain flavonoids inhibit the activation of AhR and suppress its DNA binding activity.	Flavonoids	46-56	aryl-hydrocarbon receptor	Mus musculus	83-86
25684704-7	2015	Because methanolic extract of C. asiatica showed a relatively high percentage content of quercetin and kaempferol than ethanol solution extract, the inhibitory effect of methanolic extract on CYP3A4 enzyme activity could be attributed to the flavonoids.	Flavonoids	242-252	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	192-198
24689869-6	2015	Furthermore, RCD1 had no role on PDX1 accumulation but modulated the UV-B induction of flavonoid accumulation in leaves of Arabidopsis exposed to solar UV.	Flavonoids	87-96	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	13-17
25684704-6	2015	The flavonoids, quercetin, and kaempferol showed potent (IC50 values less than 100 muM) inhibition of CYP3A4 activity, whereas quercetin alone showed potent inhibition of CYP2D6 activity in HLM.	Flavonoids	4-14	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	171-177
25656645-6	2015	The decreased association constants and the increased binding distance of NDP binding to HSA in the presence of flavonoids were both due to their competitive binding to the site I of HSA.	Flavonoids	112-122	norrin cystine knot growth factor NDP	Homo sapiens	74-77
25857233-6	2015	Flavonoids possessed strong inhibitory effect on CYP2A6 in reversible mode, while inhibition by hirsutinolides was mechanism-based (NADPH-, concentration-, and time-dependence) and irreversible.	Flavonoids	0-10	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	49-55
25857233-8	2015	Flavonoids inhibited MAOs with variable degrees and were more prominent in inhibition toward MAO-A than hirsutinolides, while two of hirsutinolides inhibited MAO-B approximately comparable to two flavonoids.	Flavonoids	0-10	monoamine oxidase A	Homo sapiens	93-98
25656645-7	2015	The results obtained from synchronous fluorescence and three-dimensional fluorescence spectra showed that the interaction between HSA and NDP caused the conformational changes of HSA and the synergism effects of NDP and flavonoids induced the further conformational changes of HSA.	Flavonoids	220-230	norrin cystine knot growth factor NDP	Homo sapiens	138-141
25896054-0	2015	[Polymethoxylated flavonoids activate cystic fibrosis transmembrane conductance regulator chloride channel].	Flavonoids	18-28	CF transmembrane conductance regulator	Rattus norvegicus	38-89
25896054-2	2015	Previously, we identified two polymethoxylated flavonoids, 3",4",5,5",6,7-hexamethoxyflavone (HMF) and 5-hydroxy-6,7,3",4"-tetramethoxyflavone (HTF) which could potentiate CFTR chloride channel activities.	Flavonoids	47-57	CF transmembrane conductance regulator	Rattus norvegicus	172-176
25896054-5	2015	Notably, HMF showed the highest affinity (EC50 = 2 mumol/L) to CFTR protein among the flavonoid CFTR activators identified so far.	Flavonoids	86-95	CF transmembrane conductance regulator	Rattus norvegicus	63-67
25896054-5	2015	Notably, HMF showed the highest affinity (EC50 = 2 mumol/L) to CFTR protein among the flavonoid CFTR activators identified so far.	Flavonoids	86-95	CF transmembrane conductance regulator	Rattus norvegicus	96-100
25896054-10	2015	The results provide new clues in elucidating structure and activity relationship of flavonoid CFTR activators.	Flavonoids	84-93	CF transmembrane conductance regulator	Rattus norvegicus	94-98
25913925-4	2015	Benzofuroisocoumarin 4, flavonoids 9, 10, and 13-15, and homoisoflavonoids 19 and 20 exhibited significant binding activity to estrogen-receptor alpha and/or beta as demonstrated by the SEAP reporter assay system in an MCF-7 cell-line.	Flavonoids	24-34	estrogen receptor 1	Homo sapiens	127-150
25655214-2	2015	In the flavonoid class of compounds, 7,8-dihydroxyflavone (7,8-DHF) has been reported to elicit tyrosine kinase receptor B (TrkB) dimerization and autophosphorylation that further stimulates signaling cascades to promote cell survival/growth, differentiation, and plasticity.	Flavonoids	7-16	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	96-122
25655214-2	2015	In the flavonoid class of compounds, 7,8-dihydroxyflavone (7,8-DHF) has been reported to elicit tyrosine kinase receptor B (TrkB) dimerization and autophosphorylation that further stimulates signaling cascades to promote cell survival/growth, differentiation, and plasticity.	Flavonoids	7-16	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	124-128
25656645-0	2015	Spectroscopic investigation on the food components-drug interaction: the influence of flavonoids on the affinity of nifedipine to human serum albumin.	Flavonoids	86-96	albumin	Homo sapiens	136-149
25765892-1	2015	The consumption of dietary flavonoids has been associated with a variety of health benefits, including effects mediated by the activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma).	Flavonoids	27-37	peroxisome proliferator activated receptor gamma	Homo sapiens	141-189
25139581-0	2015	Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	19-24
25765892-1	2015	The consumption of dietary flavonoids has been associated with a variety of health benefits, including effects mediated by the activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma).	Flavonoids	27-37	peroxisome proliferator activated receptor gamma	Homo sapiens	191-201
25765892-3	2015	To investigate the effect of glucuronidation on the ability of flavonoids to activate PPAR-gamma we studied and compared the activity of quercetin, kaempferol and their relevant plasma conjugates quercetin-3-O-glucuronide (Q3G) and kaempferol-3-O-glucuronide (K3G) on different PPAR-gamma related endpoints.	Flavonoids	63-73	peroxisome proliferator activated receptor gamma	Homo sapiens	86-96
25765892-4	2015	The flavonoid aglycones increased PPAR-gamma mediated gene expression in a stably transfected reporter gene cell line and glucuronidation diminished their effect.	Flavonoids	4-13	peroxisome proliferator activated receptor gamma	Homo sapiens	34-44
25765892-8	2015	It is concluded that flavonoids affect PPAR-gamma mediated gene transcription by a mode of action different from agonist binding.	Flavonoids	21-31	peroxisome proliferator activated receptor gamma	Homo sapiens	39-49
25139581-0	2015	Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood.	Flavonoids	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	29-34
25139581-3	2015	This study was undertaken to study an hitherto not evaluated group of flavonoids, concerning its capacity to inhibit COX-1 and COX-2 enzymes, as well as to inhibit the production of the cytokines and a chemokine, in a complex matrix involved in the systemic inflammatory process, the blood, aiming the establishment of a structure-activity relationship.	Flavonoids	70-80	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	117-122
25139581-3	2015	This study was undertaken to study an hitherto not evaluated group of flavonoids, concerning its capacity to inhibit COX-1 and COX-2 enzymes, as well as to inhibit the production of the cytokines and a chemokine, in a complex matrix involved in the systemic inflammatory process, the blood, aiming the establishment of a structure-activity relationship.	Flavonoids	70-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	127-132
25547066-1	2015	In this study we analyzed the protective action of the flavonoid rutin on peroxynitrite (ONOO(-)) mediated impairment of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1 isoform), especially related to posttranslational and conformational changes.	Flavonoids	55-64	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	159-165
25901170-0	2015	Flavonoids from Salvia chloroleuca with alpha-Amylsae and alpha-Glucosidase Inhibitory Effect.	Flavonoids	0-10	sucrase-isomaltase	Homo sapiens	58-75
25547066-3	2015	Upon treatment with ONOO(-), this flavonoid also prevented SERCA1 from thiol group oxidation and significantly reduced tyrosine nitration and protein carbonyl formation.	Flavonoids	34-43	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	59-65
25659381-9	2015	Our results indicate that VvMYB4a and VvMYB4b may play a key role in negatively regulating the synthesis of small-weight phenolic compounds, whereas VvMYBC2-L1 and VvMYBC2-L3 may additionally fine tune flavonoid levels, balancing the inductive effects of transcriptional activators.	Flavonoids	202-211	flavonoid-related R2R3 MYB 4a repressor transcription factor	Vitis vinifera	26-33
25659381-9	2015	Our results indicate that VvMYB4a and VvMYB4b may play a key role in negatively regulating the synthesis of small-weight phenolic compounds, whereas VvMYBC2-L1 and VvMYBC2-L3 may additionally fine tune flavonoid levels, balancing the inductive effects of transcriptional activators.	Flavonoids	202-211	R2R3 MYB 4b transcription factor	Vitis vinifera	38-45
25659381-9	2015	Our results indicate that VvMYB4a and VvMYB4b may play a key role in negatively regulating the synthesis of small-weight phenolic compounds, whereas VvMYBC2-L1 and VvMYBC2-L3 may additionally fine tune flavonoid levels, balancing the inductive effects of transcriptional activators.	Flavonoids	202-211	R2R3 Myb transcription factor C2 repressor motif protein	Vitis vinifera	149-159
26281599-10	2015	The most interesting finding of this study was that the anti-inflammatory effect of flavonoid compounds may be partly attributable to inhibite FOS, PTGS2 expression, inhibite of IL-1beta release, and block the MAPK pathway and toll-like receptor pathway.	Flavonoids	84-93	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-146
26281599-10	2015	The most interesting finding of this study was that the anti-inflammatory effect of flavonoid compounds may be partly attributable to inhibite FOS, PTGS2 expression, inhibite of IL-1beta release, and block the MAPK pathway and toll-like receptor pathway.	Flavonoids	84-93	interleukin 1 beta	Homo sapiens	178-186
26281599-10	2015	The most interesting finding of this study was that the anti-inflammatory effect of flavonoid compounds may be partly attributable to inhibite FOS, PTGS2 expression, inhibite of IL-1beta release, and block the MAPK pathway and toll-like receptor pathway.	Flavonoids	84-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-153
25892959-4	2015	The antidiabetic potential of flavonoids are mainly through their modulatory effects on glucose transporter by enhancing GLUT-2 expression in pancreatic beta cells and increasing expression and promoting translocation of GLUT-4 via PI3K/AKT, CAP/Cb1/TC10 and AMPK pathways.	Flavonoids	30-40	solute carrier family 2 member 2	Homo sapiens	121-127
25892959-4	2015	The antidiabetic potential of flavonoids are mainly through their modulatory effects on glucose transporter by enhancing GLUT-2 expression in pancreatic beta cells and increasing expression and promoting translocation of GLUT-4 via PI3K/AKT, CAP/Cb1/TC10 and AMPK pathways.	Flavonoids	30-40	solute carrier family 2 member 4	Homo sapiens	221-227
25892959-4	2015	The antidiabetic potential of flavonoids are mainly through their modulatory effects on glucose transporter by enhancing GLUT-2 expression in pancreatic beta cells and increasing expression and promoting translocation of GLUT-4 via PI3K/AKT, CAP/Cb1/TC10 and AMPK pathways.	Flavonoids	30-40	AKT serine/threonine kinase 1	Homo sapiens	237-240
25892959-4	2015	The antidiabetic potential of flavonoids are mainly through their modulatory effects on glucose transporter by enhancing GLUT-2 expression in pancreatic beta cells and increasing expression and promoting translocation of GLUT-4 via PI3K/AKT, CAP/Cb1/TC10 and AMPK pathways.	Flavonoids	30-40	cannabinoid receptor 1	Homo sapiens	246-249
25892959-4	2015	The antidiabetic potential of flavonoids are mainly through their modulatory effects on glucose transporter by enhancing GLUT-2 expression in pancreatic beta cells and increasing expression and promoting translocation of GLUT-4 via PI3K/AKT, CAP/Cb1/TC10 and AMPK pathways.	Flavonoids	30-40	ras homolog family member Q	Homo sapiens	250-254
25335455-6	2015	Flavonoid-modified surfaces show anti-inflammatory and anti-fibrotic potential on HGF.	Flavonoids	0-9	hepatocyte growth factor	Homo sapiens	82-85
25625231-2	2015	The flavonoids chrysin, baicalein and galangin have been reported to activate CAR and interfere with EGFR signaling.	Flavonoids	4-14	nuclear receptor subfamily 1 group I member 3	Homo sapiens	78-81
25625231-2	2015	The flavonoids chrysin, baicalein and galangin have been reported to activate CAR and interfere with EGFR signaling.	Flavonoids	4-14	epidermal growth factor receptor	Homo sapiens	101-105
25625231-9	2015	These data suggest that flavonoids chrysin, galangin and baicalein are indirect human CAR activators.	Flavonoids	24-34	nuclear receptor subfamily 1 group I member 3	Homo sapiens	86-89
25835362-3	2015	The flavonoid-rich fraction and fluoxetine improved significantly (P &lt; 0.05) the activities of the antioxidant enzymes such as superoxide dismutase and catalase as well as other biochemical parameters such as reduced glutathione, protein, and nitrite in the brain of the stressed rats.	Flavonoids	4-13	catalase	Rattus norvegicus	155-163
25650313-6	2015	Computational docking studies with an x-ray derived MPG structure as well as comparison studies with other structurally-related flavonoids offer a rationale for the inhibitory activity of morin hydrate observed.	Flavonoids	128-138	N-methylpurine DNA glycosylase	Homo sapiens	52-55
25319353-4	2015	In this study, SMN2-inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients.	Flavonoids	63-72	survival of motor neuron 2, centromeric	Homo sapiens	15-19
32480674-6	2015	Concurrently, the biosynthetic genes, tyrosine decarboxylase (TyDC) and tyramine hydroxycinnamoyl transferase (THT), involved in the biosynthesis of hydroxycinnamic acid amides (HCAAs), and chalcone synthase (CHS) and flavonol synthase (FLS), involved in flavonoid biosynthesis, were also upregulated, as confirmed by quantitative real-time PCR.	Flavonoids	255-264	tyramine N-feruloyltransferase 4/11-like	Solanum tuberosum	72-109
25549925-0	2015	Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1).	Flavonoids	35-45	carbonyl reductase 1	Homo sapiens	70-90
25549925-0	2015	Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1).	Flavonoids	35-45	carbonyl reductase 1	Homo sapiens	92-96
25549925-4	2015	In this study, we evaluated 27 flavonoids for their inhibitory activities of CBR1 in order to explore the structure-activity relationship (SAR).	Flavonoids	31-41	carbonyl reductase 1	Homo sapiens	77-81
25549925-7	2015	The SAR of the flavonoids indicated that the 7-hydroxy group of luteolin was responsible for the potent inhibition of CBR1.	Flavonoids	15-25	sarcosine dehydrogenase	Homo sapiens	4-7
25549925-7	2015	The SAR of the flavonoids indicated that the 7-hydroxy group of luteolin was responsible for the potent inhibition of CBR1.	Flavonoids	15-25	carbonyl reductase 1	Homo sapiens	118-122
32480674-6	2015	Concurrently, the biosynthetic genes, tyrosine decarboxylase (TyDC) and tyramine hydroxycinnamoyl transferase (THT), involved in the biosynthesis of hydroxycinnamic acid amides (HCAAs), and chalcone synthase (CHS) and flavonol synthase (FLS), involved in flavonoid biosynthesis, were also upregulated, as confirmed by quantitative real-time PCR.	Flavonoids	255-264	tyramine N-feruloyltransferase 4/11-like	Solanum tuberosum	111-114
32480674-6	2015	Concurrently, the biosynthetic genes, tyrosine decarboxylase (TyDC) and tyramine hydroxycinnamoyl transferase (THT), involved in the biosynthesis of hydroxycinnamic acid amides (HCAAs), and chalcone synthase (CHS) and flavonol synthase (FLS), involved in flavonoid biosynthesis, were also upregulated, as confirmed by quantitative real-time PCR.	Flavonoids	255-264	flavonol synthase/flavanone 3-hydroxylase	Solanum tuberosum	218-235
32480674-6	2015	Concurrently, the biosynthetic genes, tyrosine decarboxylase (TyDC) and tyramine hydroxycinnamoyl transferase (THT), involved in the biosynthesis of hydroxycinnamic acid amides (HCAAs), and chalcone synthase (CHS) and flavonol synthase (FLS), involved in flavonoid biosynthesis, were also upregulated, as confirmed by quantitative real-time PCR.	Flavonoids	255-264	flavonol synthase/flavanone 3-hydroxylase	Solanum tuberosum	237-240
25625417-6	2015	In particular, few sophisticated kinase-inhibitors as well as a flavonoid myricetin showed high inhibitory activities, which could thus be considered as potential lead compounds to develop new potent, selective mTOR-inhibitors.	Flavonoids	64-73	mechanistic target of rapamycin kinase	Homo sapiens	211-215
25542418-1	2015	Physiological concentrations (1 muM) of 15 flavonoids were evaluated in human umbilical vein endothelial cells in the presence of hydrogen peroxide (H2O2) for their ability to affect endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) expression in order to establish the structural basis of their bioactivity.	Flavonoids	43-53	nitric oxide synthase 3	Homo sapiens	183-216
25542418-1	2015	Physiological concentrations (1 muM) of 15 flavonoids were evaluated in human umbilical vein endothelial cells in the presence of hydrogen peroxide (H2O2) for their ability to affect endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) expression in order to establish the structural basis of their bioactivity.	Flavonoids	43-53	nitric oxide synthase 3	Homo sapiens	218-222
25542418-1	2015	Physiological concentrations (1 muM) of 15 flavonoids were evaluated in human umbilical vein endothelial cells in the presence of hydrogen peroxide (H2O2) for their ability to affect endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) expression in order to establish the structural basis of their bioactivity.	Flavonoids	43-53	endothelin 1	Homo sapiens	228-240
25542418-1	2015	Physiological concentrations (1 muM) of 15 flavonoids were evaluated in human umbilical vein endothelial cells in the presence of hydrogen peroxide (H2O2) for their ability to affect endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) expression in order to establish the structural basis of their bioactivity.	Flavonoids	43-53	endothelin 1	Homo sapiens	242-246
25542418-2	2015	Flavonoid effects on eNOS transcription factor Krupple like factor-2 (KLF-2) expression were also evaluated.	Flavonoids	0-9	nitric oxide synthase 3	Homo sapiens	21-25
25542418-2	2015	Flavonoid effects on eNOS transcription factor Krupple like factor-2 (KLF-2) expression were also evaluated.	Flavonoids	0-9	Kruppel like factor 2	Homo sapiens	47-68
25542418-2	2015	Flavonoid effects on eNOS transcription factor Krupple like factor-2 (KLF-2) expression were also evaluated.	Flavonoids	0-9	Kruppel like factor 2	Homo sapiens	70-75
25542418-4	2015	Notably, the more effective flavonoids for KLF-2 up-regulation resulted in the highest values for eNOS expression, showing that the increment of eNOS expression would take place through KLF-2 induction.	Flavonoids	28-38	Kruppel like factor 2	Homo sapiens	43-48
25542418-4	2015	Notably, the more effective flavonoids for KLF-2 up-regulation resulted in the highest values for eNOS expression, showing that the increment of eNOS expression would take place through KLF-2 induction.	Flavonoids	28-38	nitric oxide synthase 3	Homo sapiens	98-102
25542418-4	2015	Notably, the more effective flavonoids for KLF-2 up-regulation resulted in the highest values for eNOS expression, showing that the increment of eNOS expression would take place through KLF-2 induction.	Flavonoids	28-38	nitric oxide synthase 3	Homo sapiens	145-149
25542418-4	2015	Notably, the more effective flavonoids for KLF-2 up-regulation resulted in the highest values for eNOS expression, showing that the increment of eNOS expression would take place through KLF-2 induction.	Flavonoids	28-38	Kruppel like factor 2	Homo sapiens	186-191
25573539-2	2015	Limited epidemiological and animal data suggest that flavonoids, and specifically anthocyanins, may increase EPA and DHA levels, potentially by increasing their synthesis from the shorter-chain n-3 PUFA, alpha-linolenic acid.	Flavonoids	53-63	pumilio RNA binding family member 3	Homo sapiens	198-202
25614224-0	2015	Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.	Flavonoids	30-40	interleukin 33	Homo sapiens	97-102
25614224-2	2015	We herein investigated the effects of flavonoids isolated from Nepalese propolis on the IL-33 signaling pathway to clarify the anti-inflammatory mechanism involved.	Flavonoids	38-48	interleukin 33	Homo sapiens	88-93
25614224-4	2015	These four flavonoids also inhibited the IL-33-induced activation of nuclear factor kappaB (NF-kappaB), which was consistent with their inhibitory effects on cytokine expression.	Flavonoids	11-21	interleukin 33	Homo sapiens	41-46
25614224-4	2015	These four flavonoids also inhibited the IL-33-induced activation of nuclear factor kappaB (NF-kappaB), which was consistent with their inhibitory effects on cytokine expression.	Flavonoids	11-21	nuclear factor kappa B subunit 1	Homo sapiens	92-101
25614224-5	2015	The effects of these flavonoids are attributed to inhibition of IL-33-induced activation of IKK, which leads to the degradation of IkappaBalpha and nuclear localization of NF-kappaB.	Flavonoids	21-31	interleukin 33	Homo sapiens	64-69
25614224-5	2015	The effects of these flavonoids are attributed to inhibition of IL-33-induced activation of IKK, which leads to the degradation of IkappaBalpha and nuclear localization of NF-kappaB.	Flavonoids	21-31	NFKB inhibitor alpha	Homo sapiens	131-143
25614224-5	2015	The effects of these flavonoids are attributed to inhibition of IL-33-induced activation of IKK, which leads to the degradation of IkappaBalpha and nuclear localization of NF-kappaB.	Flavonoids	21-31	nuclear factor kappa B subunit 1	Homo sapiens	172-181
25895265-3	2015	In the current study, the inhibitory effect of various flavonoid compounds on fat mass and obesity associated protein (FTO) was assessed.	Flavonoids	55-64	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	119-122
25895265-6	2015	Autodock tools were used for docking flavonoids and antiobesity drug orlistat with FTO.	Flavonoids	37-47	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	83-86
25663299-0	2015	Epimedium flavonoids ameliorate neuropathological changes and increases IGF-1 expression in C57BL/6 mice exposed to cuprizone.	Flavonoids	10-20	insulin-like growth factor 1	Mus musculus	72-77
25669997-10	2015	The flavonoid luteolin blocks microglia and MC activation, provides BDNF-like activity, reverses Rett phenotype in mouse models, and has a significant benefit in children with ASDs.	Flavonoids	4-13	brain derived neurotrophic factor	Mus musculus	68-72
24990614-6	2015	Consistently, inhibition of the enzymatic activities of CD38 using the flavonoid kuromanin blocks CLL chemotaxis, adhesion and in vivo homing.	Flavonoids	71-80	CD38 molecule	Homo sapiens	56-60
25528476-0	2015	A natural flavonoid glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental autoimmune encephalomyelitis.	Flavonoids	10-19	negative elongation factor complex member C/D, Th1l	Mus musculus	47-50
25434704-1	2015	7,8-Dihydroxyflavone (7,8-DHF) is a member of the flavonoid family and has recently been identified as a brain-derived neurotrophic factor mimetic that selectively activates tropomyosin-receptor kinase B with high affinity.	Flavonoids	50-59	brain derived neurotrophic factor	Homo sapiens	105-138
25628407-9	2015	Every interquartile-range increase in flavonoid intake was associated with 5.09% reduction in mean TLR2 methylation (95% CI: 0.12% to 10.06%; P=0.05) and counteracted the effects of PM2.5 on low frequency (P(interaction)=0.05).	Flavonoids	38-47	toll like receptor 2	Homo sapiens	99-103
25385351-3	2015	A key branch-point enzyme, chalcone isomerase, catalyzes the reaction producing flavanones, the backbone for many downstream metabolites such as flavonoids and isoflavonoids.	Flavonoids	145-155	chalcone--flavonone isomerase 1A	Glycine max	27-45
25628407-12	2015	Higher flavonoid intake may attenuate these effects, possibly by decreasing TLR2 methylation.	Flavonoids	7-16	toll like receptor 2	Homo sapiens	76-80
25251150-1	2015	Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk.	Flavonoids	86-96	LOC522736	Bos taurus	101-126
25434716-9	2015	We also demonstrated that the flavonoid hesperidin modulates neuronal cell death by inhibiting the overexpression of inflammatory markers like nuclear factor kappaB, inducible nitric oxide synthase, cyclooxygenase-2 and glial fibrillary acidic protein positive astrocytes.	Flavonoids	30-39	prostaglandin-endoperoxide synthase 2	Mus musculus	199-215
25569517-5	2015	Of these, a pentasulfated flavonoid-quinazolinone dimer 32 was found to be the most potent sulfated small inhibitor of plasmin (IC50 = 45 muM, efficacy = 100%).	Flavonoids	26-35	plasminogen	Homo sapiens	119-126
25251150-1	2015	Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk.	Flavonoids	86-96	LOC522736	Bos taurus	128-131
26557712-6	2015	GC-MS analysis of FCE showed the presence of fourteen bioactive compounds such as Terpenoids and Flavonoids, including two main constituents with anticancer activity, Squalene and Naringenin (27.71% and 24.05%), respectively.	Flavonoids	97-107	ferrochelatase	Homo sapiens	18-21
25462563-3	2015	The present study was designed to investigate the effect of the flavonoid monoHER on the onset of NAFLD in Ldlr(-/-) mice on a high-fat and high-cholesterol diet.	Flavonoids	64-73	low density lipoprotein receptor	Mus musculus	107-111
26092626-2	2015	Flavonoids have been found to play a neuroprotective role by inhibiting and/or modifying the self-assembly of the amyloid-beta (Abeta) peptide into oligomers and fibrils, which are linked to the pathogenesis of Alzheimer"s disease.	Flavonoids	0-10	amyloid beta precursor protein	Homo sapiens	114-126
26092626-2	2015	Flavonoids have been found to play a neuroprotective role by inhibiting and/or modifying the self-assembly of the amyloid-beta (Abeta) peptide into oligomers and fibrils, which are linked to the pathogenesis of Alzheimer"s disease.	Flavonoids	0-10	amyloid beta precursor protein	Homo sapiens	128-133
26092626-7	2015	Although the molecular mechanisms remain to be elucidated, flavonoids have been shown to alter the Abeta aggregation pathway to yield non-toxic, unstructured Abeta aggregates, as well as directly exerting a neuroprotective effect to cells.	Flavonoids	59-69	amyloid beta precursor protein	Homo sapiens	99-104
25684472-0	2015	Flavonoids from Orostachys japonicus A. Berger induces caspase-dependent apoptosis at least partly through activation of p38 MAPK pathway in U937 human leukemic cells.	Flavonoids	0-10	mitogen-activated protein kinase 14	Homo sapiens	121-124
25590301-4	2015	At the same time, flavonoids are reported to promote the activities of heme oxygenase-1 (HO-1) decreased by LPS.	Flavonoids	18-28	heme oxygenase 1	Mus musculus	71-87
25590301-4	2015	At the same time, flavonoids are reported to promote the activities of heme oxygenase-1 (HO-1) decreased by LPS.	Flavonoids	18-28	toll-like receptor 4	Mus musculus	108-111
26434836-5	2015	The results of exon I.1-driven luciferase reporter gene assays supported the increased inhibitory effects of flavonoid mixtures, accompanied by suppression of estrogen biosynthesis.	Flavonoids	109-118	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	20-23
26434836-6	2015	In the RT-PCR analysis, decreased patterns of aromatase promoter I.1 mRNA expressions were observed, which were similar to the aromatase inhibition patterns of flavonoids and their mixtures.	Flavonoids	160-170	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	65-68
26434836-7	2015	The present study demonstrated that three flavonoids synergistically inhibit estrogen biosynthesis through aromatase inhibition, decrease CYP19 mRNA, and induce transcriptional suppression.	Flavonoids	42-52	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	138-143
25685784-10	2015	Taken together, our results suggest that the flavonoids myricetin, isorhamnetin, and quercetin may affect the activities of porcine CYP1A, CYP3A, and CYP2E1 in a gender-dependent manner.	Flavonoids	45-55	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	150-156
26467069-3	2015	In particular, flavonoids could interfere with statins" bioavailability through different mechanisms, such as competition with cytochrome P450 (CYP) enzymes, esterases, uridine diphosphate glucuronosyltransferases and transporters (P-glycoprotein, multi-drug resistance-associated proteins, organic anion transporting polypeptides, breast cancer-resistance protein and monocarboxylate transporters).	Flavonoids	15-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	127-142
25266050-0	2015	A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1beta-treated hepatocytes.	Flavonoids	26-36	interleukin 1 beta	Rattus norvegicus	104-121
26467069-3	2015	In particular, flavonoids could interfere with statins" bioavailability through different mechanisms, such as competition with cytochrome P450 (CYP) enzymes, esterases, uridine diphosphate glucuronosyltransferases and transporters (P-glycoprotein, multi-drug resistance-associated proteins, organic anion transporting polypeptides, breast cancer-resistance protein and monocarboxylate transporters).	Flavonoids	15-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	144-147
26467069-3	2015	In particular, flavonoids could interfere with statins" bioavailability through different mechanisms, such as competition with cytochrome P450 (CYP) enzymes, esterases, uridine diphosphate glucuronosyltransferases and transporters (P-glycoprotein, multi-drug resistance-associated proteins, organic anion transporting polypeptides, breast cancer-resistance protein and monocarboxylate transporters).	Flavonoids	15-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	332-364
25245513-8	2015	The proposed antibacterial mechanisms of flavonoids are as follows: inhibition of nucleic acid synthesis, inhibition of cytoplasmic membrane function, inhibition of energy metabolism, inhibition of the attachment and biofilm formation, inhibition of the porin on the cell membrane, alteration of the membrane permeability, and attenuation of the pathogenicity.	Flavonoids	41-51	voltage dependent anion channel 1	Homo sapiens	254-259
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Flavonoids	22-31	interleukin 1 beta	Homo sapiens	101-109
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Flavonoids	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
25678313-3	2015	Quercetin and chrysin are naturally occurring flavonoids, reported as modulators of P-gp and DMEs.	Flavonoids	46-56	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	84-88
26311575-0	2015	Effect of Micronized Purified Flavonoid Fraction Therapy on Endothelin-1 and TNF-alpha Levels in Relation to Antioxidant Enzyme Balance in the Peripheral Blood of Women with Varicose Veins.	Flavonoids	30-39	endothelin 1	Homo sapiens	60-72
26311575-0	2015	Effect of Micronized Purified Flavonoid Fraction Therapy on Endothelin-1 and TNF-alpha Levels in Relation to Antioxidant Enzyme Balance in the Peripheral Blood of Women with Varicose Veins.	Flavonoids	30-39	tumor necrosis factor	Homo sapiens	77-86
26415702-5	2015	Many studies reviewed herein have demonstrated the potency of certain flavonoids, stilbenes and curcuminoids in the inhibition of the activity of CBR1.	Flavonoids	70-80	carbonyl reductase 1	Homo sapiens	146-150
26059353-6	2015	Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4.	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179
26059353-6	2015	Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4.	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
25737734-0	2015	Flavonoid 4"-O-Methylkuwanon E from Morus alba Induces the Differentiation of THP-1 Human Leukemia Cells.	Flavonoids	0-9	GLI family zinc finger 2	Homo sapiens	78-83
25892545-0	2015	The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells.	Flavonoids	4-13	BCL2 apoptosis regulator	Homo sapiens	69-74
26089934-0	2015	The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells.	Flavonoids	4-13	tumor protein p53	Homo sapiens	89-92
26089934-0	2015	The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells.	Flavonoids	4-13	AKT serine/threonine kinase 1	Homo sapiens	126-129
25709964-0	2015	Three-dimensional quantitative structure-activity relationships and docking studies of some structurally diverse flavonoids and design of new aldose reductase inhibitors.	Flavonoids	113-123	aldo-keto reductase family 1 member B	Homo sapiens	142-158
25845666-0	2015	The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway.	Flavonoids	4-13	AKT serine/threonine kinase 1	Homo sapiens	90-93
25709964-4	2015	Flavonoid type compounds are shown to have significant AR inhibition.	Flavonoids	0-9	aldo-keto reductase family 1 member B	Homo sapiens	55-57
25709964-5	2015	The objective of this study was to perform a computational work to get an idea about structural insight of flavonoid type compounds for developing as well as for searching new flavonoid based AR inhibitors.	Flavonoids	107-116	aldo-keto reductase family 1 member B	Homo sapiens	192-194
25709964-5	2015	The objective of this study was to perform a computational work to get an idea about structural insight of flavonoid type compounds for developing as well as for searching new flavonoid based AR inhibitors.	Flavonoids	176-185	aldo-keto reductase family 1 member B	Homo sapiens	192-194
25922567-0	2015	The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets.	Flavonoids	12-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	78-81
24702656-0	2015	Molecular docking and 3D-QSAR-based virtual screening of flavonoids as potential aromatase inhibitors against estrogen-dependent breast cancer.	Flavonoids	57-67	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	81-90
24702656-3	2015	Thus, a three-dimensional quantitative structure-activity relationship, using comparative molecular field analysis (CoMFA) was done on a series of 45 flavonoids against human aromatase.	Flavonoids	150-160	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	175-184
24702656-9	2015	To the best of our knowledge, this is the first report of CoMFA-based QSAR model for virtual screening of flavonoids as inhibitors of aromatase.	Flavonoids	106-116	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	134-143
26052151-3	2015	Although antioxidative nutrients suppress atrogene expression in skeletal muscle cells, the inhibitory effects of flavonoids on inflammation-induced atrogin-1/MAFbx expression have not been clarified.	Flavonoids	114-124	F-box protein 32	Mus musculus	149-158
26052151-3	2015	Although antioxidative nutrients suppress atrogene expression in skeletal muscle cells, the inhibitory effects of flavonoids on inflammation-induced atrogin-1/MAFbx expression have not been clarified.	Flavonoids	114-124	F-box protein 32	Mus musculus	159-164
26052151-4	2015	Here, we investigated the inhibitory effects of flavonoids on lipopolysaccharide (LPS)-induced atrogin-1/MAFbx expression.	Flavonoids	48-58	toll-like receptor 4	Mus musculus	82-85
26052151-4	2015	Here, we investigated the inhibitory effects of flavonoids on lipopolysaccharide (LPS)-induced atrogin-1/MAFbx expression.	Flavonoids	48-58	F-box protein 32	Mus musculus	95-104
26052151-5	2015	We examined whether nine flavonoids belonging to six flavonoid categories inhibited atrogin-1/MAFbx expression in mouse C2C12 myotubes.	Flavonoids	25-35	F-box protein 32	Mus musculus	84-93
26052151-5	2015	We examined whether nine flavonoids belonging to six flavonoid categories inhibited atrogin-1/MAFbx expression in mouse C2C12 myotubes.	Flavonoids	25-35	F-box protein 32	Mus musculus	94-99
26052151-5	2015	We examined whether nine flavonoids belonging to six flavonoid categories inhibited atrogin-1/MAFbx expression in mouse C2C12 myotubes.	Flavonoids	25-34	F-box protein 32	Mus musculus	84-93
26052151-5	2015	We examined whether nine flavonoids belonging to six flavonoid categories inhibited atrogin-1/MAFbx expression in mouse C2C12 myotubes.	Flavonoids	25-34	F-box protein 32	Mus musculus	94-99
25922567-0	2015	The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets.	Flavonoids	12-21	spleen associated tyrosine kinase	Homo sapiens	83-86
25922567-0	2015	The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets.	Flavonoids	12-21	interleukin 1 receptor associated kinase 1	Homo sapiens	88-93
25922567-0	2015	The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets.	Flavonoids	12-21	interleukin 1 receptor associated kinase 4	Homo sapiens	99-104
26180592-8	2015	Treatment with both flavonoids caused significant reduction in the mRNA level of COX-2, but the anti-inflammatory effect of the methylated analogue was more effective than the unmethylated one.	Flavonoids	20-30	cytochrome c oxidase subunit II	Sus scrofa	81-86
25873069-0	2015	Regulation of Hypoxia-inducible Factor-1alpha and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids.	Flavonoids	104-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-45
25873069-0	2015	Regulation of Hypoxia-inducible Factor-1alpha and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids.	Flavonoids	104-114	vascular endothelial growth factor A	Homo sapiens	50-84
26757127-4	2015	METHODS: After flavonoid administration by oral gavage to stomach the CYP expression at protein and mRNA levels was determined in rat liver and small intestine.	Flavonoids	15-24	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	70-73
26757127-5	2015	The effects of flavonoids on CYP1A1/2, CYP1A2 or CYP2B1/2 enzyme activities in microsomes were measured using marker activities of these enzymes.	Flavonoids	15-25	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	29-35
26757127-5	2015	The effects of flavonoids on CYP1A1/2, CYP1A2 or CYP2B1/2 enzyme activities in microsomes were measured using marker activities of these enzymes.	Flavonoids	15-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	39-45
26757127-6	2015	Flavonoid-mediated inhibition of recombinant CYP1A2 was also assayed with luciferin-ME substrate.	Flavonoids	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	45-51
26757127-7	2015	The flavonoid interaction with aryl hydrocarbon receptor (AhR) was assayed by reporter luciferase activity in Hep2G cells.	Flavonoids	4-13	aryl hydrocarbon receptor	Homo sapiens	31-56
26757127-7	2015	The flavonoid interaction with aryl hydrocarbon receptor (AhR) was assayed by reporter luciferase activity in Hep2G cells.	Flavonoids	4-13	aryl hydrocarbon receptor	Homo sapiens	58-61
26156539-5	2015	Sulfated polysaccharides/glycopeptides and flavonoids may have synergistic effects with targeted anti-angiogenic drugs mainly targeting VEGF pathway by inhibiting bFGF and HIF-1alpha pathway, respectively.	Flavonoids	43-53	vascular endothelial growth factor A	Homo sapiens	136-140
26156539-5	2015	Sulfated polysaccharides/glycopeptides and flavonoids may have synergistic effects with targeted anti-angiogenic drugs mainly targeting VEGF pathway by inhibiting bFGF and HIF-1alpha pathway, respectively.	Flavonoids	43-53	fibroblast growth factor 2	Homo sapiens	163-167
26156539-5	2015	Sulfated polysaccharides/glycopeptides and flavonoids may have synergistic effects with targeted anti-angiogenic drugs mainly targeting VEGF pathway by inhibiting bFGF and HIF-1alpha pathway, respectively.	Flavonoids	43-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	172-182
25334018-4	2015	Apigenin, a dietary flavonoid, led to a dose-dependent inhibition of the self-renewal capacity and the protein expression of CK2alpha in HeLa-derived SFCs.	Flavonoids	20-29	casein kinase 2 alpha 2	Homo sapiens	125-133
25316600-4	2015	We undertook an in vitro screen to identify flavonoids with bioactivity at betagamma-mediated amyloid precursor protein processing, which lead to identification of a number of flavonoids bioactive at 100 nM.	Flavonoids	44-54	amyloid beta (A4) precursor protein	Mus musculus	94-119
25316600-4	2015	We undertook an in vitro screen to identify flavonoids with bioactivity at betagamma-mediated amyloid precursor protein processing, which lead to identification of a number of flavonoids bioactive at 100 nM.	Flavonoids	176-186	amyloid beta (A4) precursor protein	Mus musculus	94-119
26180598-4	2015	Additionally we assessed the ability of these flavonoids to inhibit aldose reductase enzyme activity.	Flavonoids	46-56	aldo-keto reductase family 1 member B	Homo sapiens	68-84
26180598-5	2015	We have previously shown that flavonoids can inhibit PARP activation.	Flavonoids	30-40	poly(ADP-ribose) polymerase 1	Homo sapiens	53-57
26180598-7	2015	In addition, we established that flavonoids are able to inhibit aldose reductase, the key enzyme in the polyol pathway.	Flavonoids	33-43	aldo-keto reductase family 1 member B	Homo sapiens	64-80
26423875-6	2015	Among the flavonoid components of these herbal medicines, flavone and chrysin exhibited high ligand activity for AhR.	Flavonoids	10-19	aryl hydrocarbon receptor	Homo sapiens	113-116
26180598-8	2015	We conclude that this protective effect of flavonoids on NAD(+) levels is a combination of the flavonoids ability to inhibit both PARP activation and aldose reductase enzyme activity.	Flavonoids	43-53	poly(ADP-ribose) polymerase 1	Homo sapiens	130-134
26180598-8	2015	We conclude that this protective effect of flavonoids on NAD(+) levels is a combination of the flavonoids ability to inhibit both PARP activation and aldose reductase enzyme activity.	Flavonoids	43-53	aldo-keto reductase family 1 member B	Homo sapiens	150-166
26180598-8	2015	We conclude that this protective effect of flavonoids on NAD(+) levels is a combination of the flavonoids ability to inhibit both PARP activation and aldose reductase enzyme activity.	Flavonoids	95-105	poly(ADP-ribose) polymerase 1	Homo sapiens	130-134
26180598-8	2015	We conclude that this protective effect of flavonoids on NAD(+) levels is a combination of the flavonoids ability to inhibit both PARP activation and aldose reductase enzyme activity.	Flavonoids	95-105	aldo-keto reductase family 1 member B	Homo sapiens	150-166
26039481-0	2015	CHS silencing suggests a negative cross-talk between wax and flavonoid pathways in tomato fruit cuticle.	Flavonoids	61-70	chalcone synthase 1	Solanum lycopersicum	0-3
26039481-2	2015	These flavonoids come from de novo biosynthesis due to a significant increase in chalcone synthase (CHS) activity during ripening.	Flavonoids	6-16	chalcone synthase 1	Solanum lycopersicum	81-98
26039481-2	2015	These flavonoids come from de novo biosynthesis due to a significant increase in chalcone synthase (CHS) activity during ripening.	Flavonoids	6-16	chalcone synthase 1	Solanum lycopersicum	100-103
25546350-11	2014	The results were confirmed by quantification of HIV-1 p24 antigen in supernatant from H9 and PBMC cells following flavonoid treatment.	Flavonoids	114-123	transmembrane p24 trafficking protein 2	Homo sapiens	54-57
25498599-0	2014	Computational investigation of inhibitory mechanism of flavonoids as bovine serum albumin anti-glycation agents.	Flavonoids	55-65	albumin	Homo sapiens	76-89
28962350-9	2015	In conclusion, the results suggest that gabiroba fruits exert hepatoprotective effects on HepG2 cells against the CCl4-induced toxicity, probably, at least in part, associated with the presence of antioxidant compounds, especially flavonoids.	Flavonoids	231-241	C-C motif chemokine ligand 4	Homo sapiens	114-118
25446924-8	2014	Co-treatment with AMPK inhibitor compound C diminished the beneficial effects of these flavonoids, suggesting the involvement of AMPK.	Flavonoids	87-97	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	18-22
25446924-8	2014	Co-treatment with AMPK inhibitor compound C diminished the beneficial effects of these flavonoids, suggesting the involvement of AMPK.	Flavonoids	87-97	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	129-133
25437273-17	2014	MRG-PMF1 will expand our understanding of flavonoid metabolism in the human intestine and lead to novel bioactive compounds.	Flavonoids	42-51	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	0-3
25437273-17	2014	MRG-PMF1 will expand our understanding of flavonoid metabolism in the human intestine and lead to novel bioactive compounds.	Flavonoids	42-51	polyamine modulated factor 1	Homo sapiens	4-8
25359775-5	2014	Our data provide strong support for an inhibitory effect of isoquercitrin on Wnt/beta-catenin, where the flavonoid acts downstream of beta-catenin translocation to the nuclei.	Flavonoids	105-114	catenin beta 1 L homeolog	Xenopus laevis	81-93
25359775-5	2014	Our data provide strong support for an inhibitory effect of isoquercitrin on Wnt/beta-catenin, where the flavonoid acts downstream of beta-catenin translocation to the nuclei.	Flavonoids	105-114	catenin beta 1 L homeolog	Xenopus laevis	134-146
25512113-13	2014	CONCLUSION: The flavonoids from Coreopsis tinctoria extracts can reduce blood lipid without liver function damage, showing better anti- hyperlipemia effect than Fenofibrate by down-regulating ADRP.	Flavonoids	16-26	perilipin 2	Mus musculus	192-196
25498599-2	2014	In this work, bovine serum albumin (BSA) became a subject as a model protein for analyzing the inhibitory mechanism of flavonoids, known as natural BSA glycation inhibitors in the early stage of glycation.	Flavonoids	119-129	albumin	Homo sapiens	21-34
25498599-6	2014	RESULTS: The quality assessment methods and simultaneous docking studies on interaction of quercetin (as the most studied flavonoids) with BSA and Human serum albumin (HAS), confirm the accuracy of simulation and the second stage of docking results which were in close agreement with experimental observations, suggest that the potential residues in flavonoids binding sites (which were place neighbor of tryptophan 212 within 5A) cannot be considered as one of glycation sites.	Flavonoids	122-132	albumin	Homo sapiens	153-166
25498599-6	2014	RESULTS: The quality assessment methods and simultaneous docking studies on interaction of quercetin (as the most studied flavonoids) with BSA and Human serum albumin (HAS), confirm the accuracy of simulation and the second stage of docking results which were in close agreement with experimental observations, suggest that the potential residues in flavonoids binding sites (which were place neighbor of tryptophan 212 within 5A) cannot be considered as one of glycation sites.	Flavonoids	350-360	albumin	Homo sapiens	153-166
25451794-0	2014	Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin.	Flavonoids	81-90	CF transmembrane conductance regulator	Rattus norvegicus	32-36
25455492-1	2014	In this study, a total of 22 flavonoids were tested for their HDAC inhibitory activity using fluorimetric and BRET-based assays.	Flavonoids	29-39	histone deacetylase 9	Homo sapiens	62-66
25383163-5	2014	In order to understand the structure-interaction-reactivity relationship within the flavonoid family for metal-free and metal-associated Abeta, we designed, synthesized, and characterized a set of isoflavone derivatives, aminoisoflavones (1-4), that displayed reactivity (i.e., modulation of Abeta aggregation) in vitro.	Flavonoids	84-93	amyloid beta precursor protein	Homo sapiens	137-142
25383163-6	2014	NMR studies revealed a potential binding site for aminoisoflavones between the N-terminal loop and central helix on prefibrillar Abeta different from the non-specific binding observed for other flavonoids.	Flavonoids	194-204	amyloid beta precursor protein	Homo sapiens	129-134
25471833-1	2014	This study observes the therapeutic detoxification of quercetin, a well-known flavonoid, against carbon tetrachloride (CCl4) induced acute liver injury in vivo and explores its mechanism.	Flavonoids	78-87	chemokine (C-C motif) ligand 4	Mus musculus	119-123
25281414-9	2014	Flavonoid treated mice exhibited decreased activation of splenic CD4+ cells (STAT4 phosphorylation and IFNgamma expression) and reduced plasma cytokine levels.	Flavonoids	0-9	CD4 antigen	Mus musculus	65-68
25281414-9	2014	Flavonoid treated mice exhibited decreased activation of splenic CD4+ cells (STAT4 phosphorylation and IFNgamma expression) and reduced plasma cytokine levels.	Flavonoids	0-9	signal transducer and activator of transcription 4	Mus musculus	77-82
25281414-9	2014	Flavonoid treated mice exhibited decreased activation of splenic CD4+ cells (STAT4 phosphorylation and IFNgamma expression) and reduced plasma cytokine levels.	Flavonoids	0-9	interferon gamma	Mus musculus	103-111
25262941-0	2014	Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.	Flavonoids	45-54	neuromedin U receptor 2	Homo sapiens	93-116
24738718-5	2014	We further found that mlo4/mlo11-conditioned root curling is not dependent upon light and endogenous flavonoids, but is pH-sensitive and affected by exogenous calcium levels.	Flavonoids	101-111	Seven transmembrane MLO family protein	Arabidopsis thaliana	27-32
25429875-0	2014	A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways.	Flavonoids	20-30	mitogen-activated protein kinase 1	Homo sapiens	122-126
25264278-2	2014	Previously, much effort has been devoted to the investigation of blocking Nrf2 function in cultured cells and cancer tissues, but few researches have been undertaken to evaluate the precise mechanism of flavonoids-induced sensitivity by inhibiting Nrf2.	Flavonoids	203-213	NFE2 like bZIP transcription factor 2	Homo sapiens	248-252
27379322-5	2014	The results indicated that flavonoid treated group showed significant decrease (P &lt; 0.05) in antioxidant enzyme level as compared to control in wound healing process, whereas terpenoid fraction showed significant increase (P &lt; 0.05) in expression of growth factor levels but regeneration and remodeling stages were delayed due to formation of thicker ulcus layer and also there were no hair follicle-like blood capillaries formation which ultimately may lead to formation of hypertrophic scar of wound.	Flavonoids	27-36	myotrophin	Rattus norvegicus	256-269
24966027-1	2014	Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites.	Flavonoids	173-183	aryl hydrocarbon receptor	Homo sapiens	0-25
24966027-1	2014	Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites.	Flavonoids	173-183	aryl hydrocarbon receptor	Homo sapiens	27-30
25272193-4	2014	A genome-wide association study (GWAS) with 404,628 SNP markers identified novel quantitative trait loci for sorghum polyphenols, some of which colocalized with homologues of flavonoid pathway genes from other plants, including an orthologue of maize (Zea mays) Pr1 and a homologue of Arabidopsis (Arabidopsis thaliana) TT16.	Flavonoids	175-184	pathogenesis related protein 4	Zea mays	262-265
25272193-4	2014	A genome-wide association study (GWAS) with 404,628 SNP markers identified novel quantitative trait loci for sorghum polyphenols, some of which colocalized with homologues of flavonoid pathway genes from other plants, including an orthologue of maize (Zea mays) Pr1 and a homologue of Arabidopsis (Arabidopsis thaliana) TT16.	Flavonoids	175-184	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	320-324
25262941-3	2014	Based on the structure of rutin, a typical flavonoid and one of the NMU2R agonists we previously identified from an in-house made natural product library, 30 flavonoid derivatives have been synthesized and screened on a cell-based reporter gene assay.	Flavonoids	158-167	neuromedin U receptor 2	Homo sapiens	68-73
25150162-4	2014	Quercetin, a plant flavonoid, prevented EGF-induced invasion and migration of PC-3 cells.	Flavonoids	19-28	epidermal growth factor	Homo sapiens	40-43
25111015-0	2014	Flavonoid-induced conversion of catalase to its inactive form--Compound II.	Flavonoids	0-9	catalase	Homo sapiens	32-40
25480512-6	2014	The total phenolic and flavonoid content in HCS and its antioxidant activity were evaluated by the DPPH assay.	Flavonoids	23-32	cytochrome c, somatic	Homo sapiens	44-47
25365293-5	2014	On the contrary, apoptosis and concomitant alteration in balance of BCL-2 and BAX expression as well as activation of caspase-3 were equally affected between both cells by flavonoid treatment.	Flavonoids	172-181	BCL2 apoptosis regulator	Homo sapiens	68-73
25060908-5	2014	In the present study, the effect of rutin, a natural flavonoid on the expression of ASC of NLRP3, was investigated in rats treated with ethanol (EtOH) and cerulein (Cer).	Flavonoids	53-62	PYD and CARD domain containing	Rattus norvegicus	84-87
25060908-5	2014	In the present study, the effect of rutin, a natural flavonoid on the expression of ASC of NLRP3, was investigated in rats treated with ethanol (EtOH) and cerulein (Cer).	Flavonoids	53-62	NLR family, pyrin domain containing 3	Rattus norvegicus	91-96
25116949-0	2014	GFS9/TT9 contributes to intracellular membrane trafficking and flavonoid accumulation in Arabidopsis thaliana.	Flavonoids	63-72	CLEC16A-like protein	Arabidopsis thaliana	0-4
25116949-0	2014	GFS9/TT9 contributes to intracellular membrane trafficking and flavonoid accumulation in Arabidopsis thaliana.	Flavonoids	63-72	CLEC16A-like protein	Arabidopsis thaliana	5-8
25116949-5	2014	Here, we show that a membrane trafficking factor, GFS9, has a role in flavonoid accumulation in the vacuole.	Flavonoids	70-79	CLEC16A-like protein	Arabidopsis thaliana	50-54
25116949-6	2014	We screened a library of Arabidopsis thaliana mutants with defects in vesicle trafficking, and isolated the gfs9 mutant with abnormal pale tan-colored seeds caused by low flavonoid accumulation levels.	Flavonoids	171-180	CLEC16A-like protein	Arabidopsis thaliana	108-112
25116949-12	2014	Our findings introduce a concept that plants use GFS9-mediated membrane trafficking machinery for delivery of not only proteins but also phytochemicals, such as flavonoids, to vacuoles.	Flavonoids	161-171	CLEC16A-like protein	Arabidopsis thaliana	49-53
25151578-6	2014	Some of the tested flavonoids drive neutrophil apoptosis in a caspase 3-dependent fashion.	Flavonoids	19-29	caspase 3	Homo sapiens	62-71
24903359-1	2014	MAIN CONCLUSION: We present a comprehensive overview on flavonoid-related phenotypes of A. thaliana tt and tds mutants, provide tools for their characterisation, increase the number of available alleles and demonstrate that tds3 is allelic to tt12 and tds5 to aha10.	Flavonoids	56-65	Aminotransferase-like, plant mobile domain family protein	Arabidopsis thaliana	0-4
24903359-1	2014	MAIN CONCLUSION: We present a comprehensive overview on flavonoid-related phenotypes of A. thaliana tt and tds mutants, provide tools for their characterisation, increase the number of available alleles and demonstrate that tds3 is allelic to tt12 and tds5 to aha10.	Flavonoids	56-65	autoinhibited H[+]-ATPase 	Arabidopsis thaliana	260-265
25850276-11	2014	Total flavonoids could promote the expression of GAD65 (P &lt; 0.05) and decrease the expression of GFAP and Cx43 (P &lt; 0.01) in thalamus compared with model group while it could also increased the content of Glu,gamma-GA BA to normal levels.	Flavonoids	6-16	glutamate decarboxylase 2	Rattus norvegicus	49-54
25850276-11	2014	Total flavonoids could promote the expression of GAD65 (P &lt; 0.05) and decrease the expression of GFAP and Cx43 (P &lt; 0.01) in thalamus compared with model group while it could also increased the content of Glu,gamma-GA BA to normal levels.	Flavonoids	6-16	glial fibrillary acidic protein	Rattus norvegicus	100-104
25850276-11	2014	Total flavonoids could promote the expression of GAD65 (P &lt; 0.05) and decrease the expression of GFAP and Cx43 (P &lt; 0.01) in thalamus compared with model group while it could also increased the content of Glu,gamma-GA BA to normal levels.	Flavonoids	6-16	gap junction protein, alpha 1	Rattus norvegicus	109-113
25850276-15	2014	Huanglian Jiedu decoction total flavonoids could relieve the injury of nerve cell through inhibiting the abnormal activation of astrocytes and regulating the expression of GFAP and GAD65.	Flavonoids	32-42	glial fibrillary acidic protein	Rattus norvegicus	172-176
25850276-15	2014	Huanglian Jiedu decoction total flavonoids could relieve the injury of nerve cell through inhibiting the abnormal activation of astrocytes and regulating the expression of GFAP and GAD65.	Flavonoids	32-42	glutamate decarboxylase 2	Rattus norvegicus	181-186
25365293-5	2014	On the contrary, apoptosis and concomitant alteration in balance of BCL-2 and BAX expression as well as activation of caspase-3 were equally affected between both cells by flavonoid treatment.	Flavonoids	172-181	BCL2 associated X, apoptosis regulator	Homo sapiens	78-81
25365293-5	2014	On the contrary, apoptosis and concomitant alteration in balance of BCL-2 and BAX expression as well as activation of caspase-3 were equally affected between both cells by flavonoid treatment.	Flavonoids	172-181	caspase 3	Homo sapiens	118-127
25241911-3	2014	We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin.	Flavonoids	119-129	solute carrier family 47 member 1	Homo sapiens	28-80
25108127-2	2014	Dihydroflavonol 4-reductase (DFR) is part of an important step in the flavonoid biosynthetic pathway of anthocyanins.	Flavonoids	70-79	dihydroflavonol 4-reductase	Brassica rapa	0-27
25108127-2	2014	Dihydroflavonol 4-reductase (DFR) is part of an important step in the flavonoid biosynthetic pathway of anthocyanins.	Flavonoids	70-79	dihydroflavonol 4-reductase	Brassica rapa	29-32
25219605-2	2014	The purpose of this study was to investigate the in vitro effects of multiple extracts including aqueous extracts, total flavonoids, iridoids, alkaloids from HLJDD on the activities of CYPs in rats (CYP1A2, CYP2C6, CYP2D2, CYP2E1 and CYP3A1) and P-gp, and then to predict potential interactions with co-administered drugs.	Flavonoids	121-131	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	199-205
25219605-6	2014	Total flavonoids exhibited different inhibitory effects on CYPs activities with an order of CYP3A1&gt;CYP2C6&gt;CYP2E1&gt;CYP1A2&gt;CYP2D2, and the values of IC50 were 4.24, 8.16, 17.56, 19.03, 29.51 mug/mL, respectively.	Flavonoids	6-16	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	92-98
25219605-6	2014	Total flavonoids exhibited different inhibitory effects on CYPs activities with an order of CYP3A1&gt;CYP2C6&gt;CYP2E1&gt;CYP1A2&gt;CYP2D2, and the values of IC50 were 4.24, 8.16, 17.56, 19.03, 29.51 mug/mL, respectively.	Flavonoids	6-16	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	102-108
25219605-6	2014	Total flavonoids exhibited different inhibitory effects on CYPs activities with an order of CYP3A1&gt;CYP2C6&gt;CYP2E1&gt;CYP1A2&gt;CYP2D2, and the values of IC50 were 4.24, 8.16, 17.56, 19.03, 29.51 mug/mL, respectively.	Flavonoids	6-16	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	112-118
25219605-6	2014	Total flavonoids exhibited different inhibitory effects on CYPs activities with an order of CYP3A1&gt;CYP2C6&gt;CYP2E1&gt;CYP1A2&gt;CYP2D2, and the values of IC50 were 4.24, 8.16, 17.56, 19.03, 29.51 mug/mL, respectively.	Flavonoids	6-16	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	122-128
25219605-6	2014	Total flavonoids exhibited different inhibitory effects on CYPs activities with an order of CYP3A1&gt;CYP2C6&gt;CYP2E1&gt;CYP1A2&gt;CYP2D2, and the values of IC50 were 4.24, 8.16, 17.56, 19.03, 29.51 mug/mL, respectively.	Flavonoids	6-16	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	132-138
25219605-9	2014	Results from transport assay revealed that total flavonoids and alkaloids exhibited significant inhibitory effect on P-gp activity as evidenced by strong inhibition on the efflux of Rhodamine-123 with IC50 of 104.6 and 82.6 mug/mL.	Flavonoids	49-59	phosphoglycolate phosphatase	Rattus norvegicus	117-121
25219605-11	2014	CONCLUSIONS: This study clearly demonstrated that total flavonoids and alkaloids from HLJDD can significantly inhibit the activities of CYPs and P-gp, which should be taken into consideration to predict any potential HDIs when HLJDD and its bioactive components are co-administered with other therapeutic drugs metabolized by CYPs or transported by P-gp.	Flavonoids	56-66	phosphoglycolate phosphatase	Rattus norvegicus	145-149
25219605-11	2014	CONCLUSIONS: This study clearly demonstrated that total flavonoids and alkaloids from HLJDD can significantly inhibit the activities of CYPs and P-gp, which should be taken into consideration to predict any potential HDIs when HLJDD and its bioactive components are co-administered with other therapeutic drugs metabolized by CYPs or transported by P-gp.	Flavonoids	56-66	phosphoglycolate phosphatase	Rattus norvegicus	349-353
25223958-0	2014	Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP.	Flavonoids	111-121	heme oxygenase 1	Homo sapiens	21-37
25223958-0	2014	Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP.	Flavonoids	111-121	ATP synthase inhibitory factor subunit 1	Homo sapiens	42-68
25223958-8	2014	To gain a physiological significance, we treated the synthetic flavonoids in colon cancer cells, HT29 and HCT116 cells and confirmed that overexpression of both HO-1 and ATPIF1 was critical for tumor cell death with an impaired mitochondrial energetics.	Flavonoids	63-73	heme oxygenase 1	Homo sapiens	161-165
25223958-8	2014	To gain a physiological significance, we treated the synthetic flavonoids in colon cancer cells, HT29 and HCT116 cells and confirmed that overexpression of both HO-1 and ATPIF1 was critical for tumor cell death with an impaired mitochondrial energetics.	Flavonoids	63-73	ATP synthase inhibitory factor subunit 1	Homo sapiens	170-176
23994263-0	2014	Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.	Flavonoids	92-101	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	174-178
23994263-2	2014	In the present study we investigated the interaction of the two flavonoids with cytochrome P450 CYP1 enzymes in breast cancer MCF7 cells.	Flavonoids	64-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-100
25241911-3	2014	We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin.	Flavonoids	119-129	solute carrier family 47 member 1	Homo sapiens	82-87
25190466-1	2014	Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-kappaB (NF-kappaB) signaling in the invasive breast cancer cell line MDA-MB-231.	Flavonoids	10-20	nuclear factor kappa B subunit 1	Homo sapiens	83-104
25241191-1	2014	Although the flavonoid quercetin is known to inhibit activation of insulin receptor signaling, the inhibitory mechanism is largely unknown.	Flavonoids	13-22	insulin receptor	Homo sapiens	67-83
24956178-0	2014	In vitro and in silico studies to explore structural features of flavonoids for aldehyde oxidase inhibition.	Flavonoids	65-75	aldehyde oxidase 1	Homo sapiens	80-96
24956178-1	2014	Aldehyde oxidase (AO), an important enzyme in the biotransformation of drugs and xenobiotics, is inhibited by flavonoids.	Flavonoids	110-120	aldehyde oxidase 1	Homo sapiens	0-16
24956178-1	2014	Aldehyde oxidase (AO), an important enzyme in the biotransformation of drugs and xenobiotics, is inhibited by flavonoids.	Flavonoids	110-120	aldehyde oxidase 1	Homo sapiens	18-20
24956178-3	2014	In this work, a set of 15 flavonoids was assessed for inhibitory activity on the AO oxidation of vanillin as an aldehyde substrate.	Flavonoids	26-36	aldehyde oxidase 1	Homo sapiens	81-83
24956178-8	2014	The QSAR model can be used more broadly to predict the AO inhibitory activity of flavonoid-like structures for application in food-drug and drug-drug interaction studies.	Flavonoids	81-90	aldehyde oxidase 1	Homo sapiens	55-57
25190466-8	2014	The structure-activity relations amongst the flavonoids as NF-kappaB signaling inhibitors was studied.	Flavonoids	45-55	nuclear factor kappa B subunit 1	Homo sapiens	59-68
25190466-9	2014	The study indicates differences between the actions of various flavonoids on NF-kappaB activation and on the biological activities of breast cancer cells.	Flavonoids	63-73	nuclear factor kappa B subunit 1	Homo sapiens	77-86
25190466-1	2014	Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-kappaB (NF-kappaB) signaling in the invasive breast cancer cell line MDA-MB-231.	Flavonoids	10-20	nuclear factor kappa B subunit 1	Homo sapiens	106-115
24876151-9	2014	These data demonstrate that BRM expression and function are regulated by flavonoids and that functional BRM appears to be a prerequisite for the anticancer effects of flavonoids both in vitro and in vivo.	Flavonoids	167-177	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	104-107
24876151-0	2014	Flavonoids from each of the six structural groups reactivate BRM, a possible cofactor for the anticancer effects of flavonoids.	Flavonoids	0-10	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	61-64
24876151-0	2014	Flavonoids from each of the six structural groups reactivate BRM, a possible cofactor for the anticancer effects of flavonoids.	Flavonoids	116-126	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	61-64
24876151-2	2014	In the course of this study, we found that a variety of different flavonoids readily restored Brahma (BRM) in BRM-deficient cancer cell lines.	Flavonoids	66-76	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	94-100
24876151-2	2014	In the course of this study, we found that a variety of different flavonoids readily restored Brahma (BRM) in BRM-deficient cancer cell lines.	Flavonoids	66-76	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	102-105
25143139-1	2014	The inhibitory effects of flavonoids on acetylcholinesterase (AChE) have attracted great interest among researchers.	Flavonoids	26-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-60
24876151-3	2014	Flavonoids from each of the six different structural groups were effective at inducing BRM expression as well as inhibiting growth in these BRM-deficient cancer cells.	Flavonoids	0-10	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	87-90
24876151-4	2014	By blocking the induction of BRM with shRNA, we found that flavonoid-induced growth inhibition was BRM dependent.	Flavonoids	59-68	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	29-32
24876151-4	2014	By blocking the induction of BRM with shRNA, we found that flavonoid-induced growth inhibition was BRM dependent.	Flavonoids	59-68	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	99-102
24876151-5	2014	We also found that flavonoids can restore BRM functionality by reversing BRM acetylation.	Flavonoids	19-29	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	42-45
24876151-5	2014	We also found that flavonoids can restore BRM functionality by reversing BRM acetylation.	Flavonoids	19-29	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	73-76
24876151-6	2014	In addition, we observed that an array of natural flavonoid-containing products both induced BRM expression as well as deacetylated the BRM protein.	Flavonoids	50-59	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	93-96
24876151-6	2014	In addition, we observed that an array of natural flavonoid-containing products both induced BRM expression as well as deacetylated the BRM protein.	Flavonoids	50-59	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	136-139
24876151-7	2014	We also tested two of the BRM-inducing flavonoids (Rutin and Diosmin) at both a low and a high dose on the development of tumors in an established murine lung cancer model.	Flavonoids	39-49	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	26-29
24876151-9	2014	These data demonstrate that BRM expression and function are regulated by flavonoids and that functional BRM appears to be a prerequisite for the anticancer effects of flavonoids both in vitro and in vivo.	Flavonoids	73-83	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	28-31
24972350-4	2014	Some flavonoids, e.g. rhamnetin, displaced a selective alpha7 nAChR radioligand from rat brain membranes whereas similar structures e.g. sakuranetin, did not.	Flavonoids	5-15	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	62-67
24972350-5	2014	To evaluate the contribution of this putative nAChR activity to the known anti-inflammatory properties of these flavonoids, we compared their effects on lipopolysaccharide induced release of inflammatory mediators from BV2 microglia.	Flavonoids	112-122	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	46-51
24972350-11	2014	This action, together with potent free radical scavenging activity, suggests that flavonoids with alpha7 nAChR activity have therapeutic potential in neuroinflammatory conditions.	Flavonoids	82-92	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	105-110
26461334-6	2014	Some of the tested flavonoids induce neutrophil apoptosis in a caspase 3-dependent fashion.	Flavonoids	19-29	caspase 3	Homo sapiens	63-72
25164625-0	2014	Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent against prostate cancer in an in vivo model by inhibiting the EGFR signaling pathway.	Flavonoids	29-38	epidermal growth factor receptor	Rattus norvegicus	134-138
25143139-1	2014	The inhibitory effects of flavonoids on acetylcholinesterase (AChE) have attracted great interest among researchers.	Flavonoids	26-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
25143139-2	2014	However, few reports have focused on the structure-activity relationship for AChE inhibition of flavonoids.	Flavonoids	96-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
26461385-5	2014	In this study, a series of flavonoids were tested for their capacity to interfere in human neutrophils apoptosis, assessed by flow cytometry after simultaneous staining with Annexin-V labeled with fluorescein and propidium iodide.	Flavonoids	27-37	annexin A5	Homo sapiens	174-183
25143139-3	2014	This work mainly concerns the structural aspects of inhibitory activities and binding affinities of flavonoids as AChE inhibitors.	Flavonoids	100-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-118
25143139-4	2014	The results show that hydroxyl groups in the A ring of flavonoids are favorable for inhibiting AChE, and the hydroxylation increases the affinities for AChE.	Flavonoids	55-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
25143139-4	2014	The results show that hydroxyl groups in the A ring of flavonoids are favorable for inhibiting AChE, and the hydroxylation increases the affinities for AChE.	Flavonoids	55-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-156
25143139-6	2014	The glycosylation decreases the AChE inhibitory activities of flavonoids and lowers the affinities for AChE by 1 to 5 times depending on the conjunction site and the type of sugar moiety.	Flavonoids	62-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-36
25143139-8	2014	The molecular property-affinity relationship reveals that the hydrogen bond force plays an important role in binding flavonoids to AChE.	Flavonoids	117-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
25143139-9	2014	The AChE inhibitions generally increase with the increasing affinities of flavonoids within the class, especially for flavones and flavonols.	Flavonoids	74-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
24993541-0	2014	Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB-231 partly through suppression of the Akt pathway.	Flavonoids	9-18	AKT serine/threonine kinase 1	Homo sapiens	159-162
25143370-0	2014	Evidence for an association of dietary flavonoid intake with breast cancer risk by estrogen receptor status is limited.	Flavonoids	39-48	estrogen receptor 1	Homo sapiens	83-100
27547487-3	2014	We achieved knockdown of EWS expression using a plasmid vector encoding EWS short hairpin RNA (shRNA) to increase anti-tumor mechanisms of taxifolin (TFL), a new flavonoid, in human Ewing"s sarcoma cells in culture and animal models.	Flavonoids	162-171	EWS RNA binding protein 1	Homo sapiens	25-28
27547487-3	2014	We achieved knockdown of EWS expression using a plasmid vector encoding EWS short hairpin RNA (shRNA) to increase anti-tumor mechanisms of taxifolin (TFL), a new flavonoid, in human Ewing"s sarcoma cells in culture and animal models.	Flavonoids	162-171	EWS RNA binding protein 1	Homo sapiens	72-75
28962277-3	2014	Plant flavonoids, such as flavonol quercetin and flavone luteolin, have been suggested to be potential antidepressant compounds because they exert a suppressive effect on the MAO-A reaction.	Flavonoids	6-16	monoamine oxidase A	Homo sapiens	175-180
25309465-7	2014	Further, since nutritional status has been shown to affect critical pathways involved in depression through both BDNF function and the monoamine system, we also review current evidence surrounding diet and supplementation (e.g., flavonoids) on BDNF-mediated brain functions.	Flavonoids	229-239	brain derived neurotrophic factor	Homo sapiens	244-248
25026504-12	2014	In summary, dietary flavonoid ISL effectively inhibits colitis-associated tumorigenesis through hampering M2 macrophage polarization mediated by the interplay between PGE2 and IL-6.	Flavonoids	20-29	interleukin 6	Mus musculus	176-180
25058688-7	2014	Based on glycophorin A expression, the potency of the other flavonoids for induction of differentiation, was: apigenin&gt;chrysin&gt;flavone/7-hydroxyflavone&gt;luteolin/naringenin.	Flavonoids	60-70	glycophorin A (MNS blood group)	Homo sapiens	9-22
25352726-0	2014	Targeting cysteine rich C1 domain of Scaffold protein Kinase Suppressor of Ras (KSR) with anthocyanidins and flavonoids - a binding affinity characterization study.	Flavonoids	109-119	kinase suppressor of ras 1	Homo sapiens	54-78
25352726-0	2014	Targeting cysteine rich C1 domain of Scaffold protein Kinase Suppressor of Ras (KSR) with anthocyanidins and flavonoids - a binding affinity characterization study.	Flavonoids	109-119	kinase suppressor of ras 1	Homo sapiens	80-83
25268129-0	2014	Overexpression of the PAP1 transcription factor reveals a complex regulation of flavonoid and phenylpropanoid metabolism in Nicotiana tabacum plants attacked by Spodoptera litura.	Flavonoids	80-89	phosphatidic acid phosphatase 1	Arabidopsis thaliana	22-26
25268129-4	2014	To understand the influence of herbivore attack on the metabolic engineering of flavonoids, we examined tobacco plants overexpressing the Arabidopsis PAP1 gene (encoding an MYB transcription factor), which accumulated anthocyanin pigments and other flavonoids/phenylpropanoids.	Flavonoids	80-90	phosphatidic acid phosphatase 1	Arabidopsis thaliana	150-154
25268129-4	2014	To understand the influence of herbivore attack on the metabolic engineering of flavonoids, we examined tobacco plants overexpressing the Arabidopsis PAP1 gene (encoding an MYB transcription factor), which accumulated anthocyanin pigments and other flavonoids/phenylpropanoids.	Flavonoids	249-259	phosphatidic acid phosphatase 1	Arabidopsis thaliana	150-154
25268129-6	2014	Moreover, herbivory suppressed the PAP1-induced increase of transcripts of flavonoid/phenylpropanoid biosynthetic genes (e.g., F3H) and the subsequent accumulation of these genes" metabolites, despite the unaltered PAP1 mRNA levels after herbivory.	Flavonoids	75-84	phosphatidic acid phosphatase 1	Arabidopsis thaliana	35-39
25110319-0	2014	The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells.	Flavonoids	13-22	aryl hydrocarbon receptor	Homo sapiens	73-76
25260046-0	2014	Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-kappaB inhibition in THP-1 monocytes.	Flavonoids	0-9	sirtuin 1	Homo sapiens	87-92
25260046-0	2014	Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-kappaB inhibition in THP-1 monocytes.	Flavonoids	0-9	GLI family zinc finger 2	Homo sapiens	126-131
28962277-4	2014	We evaluated the effects of these flavonoids on MAO-A activity and protein level using SH-SY5Y as model serotoninergic nerve cells.	Flavonoids	34-44	monoamine oxidase A	Homo sapiens	48-53
25362817-0	2014	Quantitative analysis of flavonoids and phenolic acids from inflorescences and aerial parts of selected Cirsium species using ASE method.	Flavonoids	25-35	arylsulfatase L	Homo sapiens	126-129
25183267-3	2014	In this study, we investigated the mechanisms by which GBE and its flavonoids induced expression of CPT1A.	Flavonoids	67-77	carnitine palmitoyltransferase 1A	Homo sapiens	100-105
25183267-7	2014	The regulatory effects of GBE on CPT1A were also verified on the flavonoid ingredients quercetin, kaempferol, and isorhamnetin.	Flavonoids	65-74	carnitine palmitoyltransferase 1A	Homo sapiens	33-38
25183267-8	2014	CONCLUSION: Sp1 was crucial in regulating CPT1A expression with GBE and its flavonoid ingredients, and the -50 to -5 nt region of CPT1A promoter played important roles in Sp1 binding.	Flavonoids	76-85	carnitine palmitoyltransferase 1A	Homo sapiens	42-47
24914470-3	2014	Previous our result demonstrated that luteolin, a natural flavonoid existing in vegetables and herbs, competed the binding of TCDD to AhR.	Flavonoids	58-67	aryl hydrocarbon receptor	Homo sapiens	134-137
25312177-8	2014	Flavonoid aglycones showed stronger antioxidant and lipoxygenase inhibitory effects than their glycosides.	Flavonoids	0-9	linoleate 9S-lipoxygenase-4	Glycine max	52-64
24950183-9	2014	By quercetin treatment, a plant flavonoid compound which is known to suppress heat shock proteins, or siRNA-mediated gene silencing, both Hsp27 expression and VM capability of BCSCs were suppressed.	Flavonoids	32-41	heat shock protein family B (small) member 1	Homo sapiens	138-143
24916123-4	2014	The objective of the present study was to determine if MIF was susceptible to modification by epicatechins, a group of dietary flavonoids with known anti-inflammatory properties.	Flavonoids	127-137	macrophage migration inhibitory factor	Homo sapiens	55-58
24932809-0	2014	Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells.	Flavonoids	35-45	solute carrier family 2 member 1	Homo sapiens	14-18
25002746-0	2014	Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport.	Flavonoids	0-10	solute carrier family 22 member 6	Homo sapiens	35-62
25002746-0	2014	Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport.	Flavonoids	0-10	solute carrier family 22 member 6	Homo sapiens	64-68
25002746-4	2014	Our objective was to evaluate the effects of 18 naturally occurring flavonoids, and some of their glycosides, on the uptake of para-aminohippuric acid (PAH) in both OAT1-expressing and OAT1-negative LLC-PK1 cells.	Flavonoids	68-78	solute carrier family 22 member 6	Sus scrofa	165-169
25002746-5	2014	Most flavonoid aglycones produced substantial decreases in PAH uptake in OAT1-expressing cells.	Flavonoids	5-14	solute carrier family 22 member 6	Homo sapiens	73-77
25002746-6	2014	Among the flavonoids screened, fisetin, luteolin, morin, and quercetin exhibited the strongest effect and produced complete inhibition of OAT1-mediated PAH uptake at a concentration of 50 muM.	Flavonoids	10-20	solute carrier family 22 member 6	Homo sapiens	138-142
25002746-6	2014	Among the flavonoids screened, fisetin, luteolin, morin, and quercetin exhibited the strongest effect and produced complete inhibition of OAT1-mediated PAH uptake at a concentration of 50 muM.	Flavonoids	10-20	latexin	Homo sapiens	188-191
24932809-4	2014	The aim of this work was to study the regulation of some GLUTs (GLUT1 and GLUT4) in both androgen-sensitive (LNCaP) and -insensitive (PC-3) prostate cancer cells by 4 structurally different flavonoids (ie, genistein, phloretin, apigenin, and daidzein).	Flavonoids	190-200	solute carrier family 2 member 1	Homo sapiens	64-69
25002746-10	2014	Taken together, our results indicate that flavonoids are a novel class of OAT1 modulators.	Flavonoids	42-52	solute carrier family 22 member 6	Homo sapiens	74-78
25002746-11	2014	Considering the high consumption of flavonoids in the diet and in herbal products, OAT1-mediated flavonoid-drug interactions may be clinically relevant.	Flavonoids	36-46	solute carrier family 22 member 6	Homo sapiens	83-87
25002746-11	2014	Considering the high consumption of flavonoids in the diet and in herbal products, OAT1-mediated flavonoid-drug interactions may be clinically relevant.	Flavonoids	36-45	solute carrier family 22 member 6	Homo sapiens	83-87
25002746-12	2014	Further investigation is warranted to evaluate the nephroprotective role of flavonoids in relation to drug-induced nephrotoxicity mediated by the OAT1 pathway.	Flavonoids	76-86	solute carrier family 22 member 6	Homo sapiens	146-150
24932809-4	2014	The aim of this work was to study the regulation of some GLUTs (GLUT1 and GLUT4) in both androgen-sensitive (LNCaP) and -insensitive (PC-3) prostate cancer cells by 4 structurally different flavonoids (ie, genistein, phloretin, apigenin, and daidzein).	Flavonoids	190-200	solute carrier family 2 member 4	Homo sapiens	74-79
24932809-8	2014	Additionally, a docking simulation was employed to compare interactions between flavonoids and XylE, a bacterial homolog of GLUT1 to -4.	Flavonoids	80-90	solute carrier family 2 member 1	Homo sapiens	124-129
24932809-10	2014	Furthermore, differences in GLUT1 and GLUT4 levels and glucose uptake were found, without differences on subcellular distribution, after incubation with flavonoids.	Flavonoids	153-163	solute carrier family 2 member 1	Homo sapiens	28-33
24932809-10	2014	Furthermore, differences in GLUT1 and GLUT4 levels and glucose uptake were found, without differences on subcellular distribution, after incubation with flavonoids.	Flavonoids	153-163	solute carrier family 2 member 4	Homo sapiens	38-43
24932809-13	2014	Thus, phenotypic characteristics of prostate cancer cells are responsible for the different effects of these flavonoids in glucose uptake and in GLUT expression rather than their structural differences, with the most effective in reducing cell growth being the highest in modifying glucose uptake and GLUT levels.	Flavonoids	109-119	solute carrier family 2 member 1	Homo sapiens	145-149
24932809-13	2014	Thus, phenotypic characteristics of prostate cancer cells are responsible for the different effects of these flavonoids in glucose uptake and in GLUT expression rather than their structural differences, with the most effective in reducing cell growth being the highest in modifying glucose uptake and GLUT levels.	Flavonoids	109-119	solute carrier family 2 member 1	Homo sapiens	301-305
25088664-1	2014	We have previously reported that procyanidins, a class of flavonoids, improve glycemia and exert an incretin-like effect, which was linked to their proven inhibitory effect on the dipeptidyl-peptidase 4 (DPP4) activity.	Flavonoids	58-68	dipeptidylpeptidase 4	Rattus norvegicus	180-202
25088664-1	2014	We have previously reported that procyanidins, a class of flavonoids, improve glycemia and exert an incretin-like effect, which was linked to their proven inhibitory effect on the dipeptidyl-peptidase 4 (DPP4) activity.	Flavonoids	58-68	dipeptidylpeptidase 4	Rattus norvegicus	204-208
24287373-1	2014	The present study investigated the effect of rutin, a natural flavonoid, on the expression of caspase activation recruitment domain (CARD) and pyrin domain (PYD) of apoptosis-associated speck-like protein (ASC), a mediator of inflammation, in the pancreas of rats administered with ethanol (EtOH) and high-fat diet (HFD).	Flavonoids	62-71	PYD and CARD domain containing	Rattus norvegicus	165-204
24287373-1	2014	The present study investigated the effect of rutin, a natural flavonoid, on the expression of caspase activation recruitment domain (CARD) and pyrin domain (PYD) of apoptosis-associated speck-like protein (ASC), a mediator of inflammation, in the pancreas of rats administered with ethanol (EtOH) and high-fat diet (HFD).	Flavonoids	62-71	PYD and CARD domain containing	Rattus norvegicus	206-209
24607839-0	2014	Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERalpha) and stimulate ER-dependent osteoblastic functions in UMR-106 cells.	Flavonoids	0-10	estrogen receptor 1	Rattus norvegicus	77-84
25205494-0	2014	Molecular docking and P-glycoprotein inhibitory activity of flavonoids.	Flavonoids	60-70	ATP binding cassette subfamily B member 1	Homo sapiens	22-36
25205494-2	2014	In the present study, Flavonoids were docked to three-dimensional structure of P-glycoprotein which plays an important role in multi drug resistance.	Flavonoids	22-32	ATP binding cassette subfamily B member 1	Homo sapiens	79-93
25205494-6	2014	With this model, a flexible docking study of P-glycoprotein with a group of Flavonoids which were selected from the previous publications was performed.	Flavonoids	76-86	ATP binding cassette subfamily B member 1	Homo sapiens	45-59
25205494-7	2014	The results indicated THR37, ALA42, ARG40 and ARG47 in P-glycoprotein are important determinant residues in binding as they have strong hydrogen bonding with Flavonoids.	Flavonoids	158-168	ATP binding cassette subfamily B member 1	Homo sapiens	55-69
25205494-9	2014	Among the 10 Flavonoids docked, BiochaninA showed best docking result with P-glycoprotein.	Flavonoids	13-23	ATP binding cassette subfamily B member 1	Homo sapiens	75-89
25026201-2	2014	The effects of the flavonoids quercetin and genistein were investigated according to their ability to inhibit the oxidation of hemoglobin and myoglobin via the Fenton"s pathway.	Flavonoids	19-29	myoglobin	Homo sapiens	142-151
25026201-3	2014	Antioxidative activity of the flavonoids were determined by oxidizing hemoglobin and myoglobin in separate experiments with 50 muM Fe(2+) and 0.01 mM hydrogen peroxide (H2O2) with and without quercetin and/or genistein.	Flavonoids	30-40	myoglobin	Homo sapiens	85-94
25026201-3	2014	Antioxidative activity of the flavonoids were determined by oxidizing hemoglobin and myoglobin in separate experiments with 50 muM Fe(2+) and 0.01 mM hydrogen peroxide (H2O2) with and without quercetin and/or genistein.	Flavonoids	30-40	latexin	Homo sapiens	127-130
25026201-10	2014	The results indicate that both flavonoids at low doses inhibited carbonylation in both hemoglobin and myoglobin and the inhibition may be attributed to the prevention of protein oxidation.	Flavonoids	31-41	myoglobin	Homo sapiens	102-111
25109996-4	2014	Other effects include the ability of flavonoids to modulate the CYP1 (cytochrome P450 1) and ABC (ATP-binding cassette) protein families, involved in carcinogenesis and drug delivery respectively.	Flavonoids	37-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-68
24947867-0	2014	Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.	Flavonoids	114-123	solute carrier organic anion transporter family member 1A2	Homo sapiens	0-39
24947867-0	2014	Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.	Flavonoids	114-123	solute carrier family 22 member 1	Homo sapiens	44-72
24916675-5	2014	Transgenic ugt79b6 mutant lines transformed with the genomic UGT79B6 gene had the same flavonoid profile as wild-type plants.	Flavonoids	87-96	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	11-18
24916675-5	2014	Transgenic ugt79b6 mutant lines transformed with the genomic UGT79B6 gene had the same flavonoid profile as wild-type plants.	Flavonoids	87-96	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	61-68
25781275-5	2014	The amount of phenolic and flavonoids contents followed the order SPL &gt; SPR &gt; SPS at 250 1000 microg/ml.	Flavonoids	27-37	sphingosine-1-phosphate lyase 1	Rattus norvegicus	66-69
25781275-5	2014	The amount of phenolic and flavonoids contents followed the order SPL &gt; SPR &gt; SPS at 250 1000 microg/ml.	Flavonoids	27-37	sepiapterin reductase	Rattus norvegicus	75-78
25317165-3	2014	In this short review, I briefly introduce small natural compounds such as flavonoids that successfully increase activation of the BDNF system and discuss their beneficial effects against neurodegeneration.	Flavonoids	74-84	brain derived neurotrophic factor	Homo sapiens	130-134
24875445-0	2014	Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux.	Flavonoids	65-75	ATP binding cassette subfamily B member 1	Homo sapiens	36-40
24619567-0	2014	Beyond organoleptic characteristics: the pharmacological potential of flavonoids and their role in leukocyte migration and in L-selectin and beta2-integrin expression during inflammation.	Flavonoids	70-80	selectin L	Rattus norvegicus	126-136
24643916-0	2014	The influence of selected flavonoids from the leaves of Cirsium palustre (L.) Scop.	Flavonoids	26-36	PH domain and leucine rich repeat protein phosphatase 1	Homo sapiens	78-82
25175005-2	2014	In this study we investigated the effect of the flavonoid present in green tea, namely epigallocatechin-3-gallate (EGCG), on the proliferation of, and IFN-gamma production by, peripheral blood mononuclear cells (PBMC) from breast cancer patients stimulated with a mitogen, anti-CD3 and the common breast cancer peptides Her-2/neu, and p53.	Flavonoids	48-57	interferon gamma	Homo sapiens	151-160
25109996-4	2014	Other effects include the ability of flavonoids to modulate the CYP1 (cytochrome P450 1) and ABC (ATP-binding cassette) protein families, involved in carcinogenesis and drug delivery respectively.	Flavonoids	37-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	70-87
25109996-4	2014	Other effects include the ability of flavonoids to modulate the CYP1 (cytochrome P450 1) and ABC (ATP-binding cassette) protein families, involved in carcinogenesis and drug delivery respectively.	Flavonoids	37-47	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	93-96
25109996-4	2014	Other effects include the ability of flavonoids to modulate the CYP1 (cytochrome P450 1) and ABC (ATP-binding cassette) protein families, involved in carcinogenesis and drug delivery respectively.	Flavonoids	37-47	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	98-118
24768712-0	2014	Flavonoids inhibit iNOS production via mitogen activated proteins in lipoteichoic acid stimulated cardiomyoblasts.	Flavonoids	0-10	nitric oxide synthase 2, inducible	Mus musculus	19-23
25229015-3	2014	The present study aimed to identify flavonoid compounds that could inhibit Abeta-induced neuronal death by examining the effects of various flavonoids on the neurotoxicity of Abeta fragment 25-35 (Abeta25-35) in mouse cortical cultures.	Flavonoids	36-45	amyloid beta (A4) precursor protein	Mus musculus	75-80
24880994-0	2014	An investigation of molecular dynamics simulation and molecular docking: interaction of citrus flavonoids and bovine beta-lactoglobulin in focus.	Flavonoids	95-105	beta-lactoglobulin	Bos taurus	117-135
24880994-4	2014	The molecular docking results revealed that these flavonoids bind in the internal cavity of BLG and the BLG affinity for binding the flavonoids follows naringenin&gt;hesperetin&gt;tangeretin&gt;nobiletin.	Flavonoids	50-60	beta-lactoglobulin	Bos taurus	92-95
24880994-4	2014	The molecular docking results revealed that these flavonoids bind in the internal cavity of BLG and the BLG affinity for binding the flavonoids follows naringenin&gt;hesperetin&gt;tangeretin&gt;nobiletin.	Flavonoids	50-60	beta-lactoglobulin	Bos taurus	104-107
24880994-4	2014	The molecular docking results revealed that these flavonoids bind in the internal cavity of BLG and the BLG affinity for binding the flavonoids follows naringenin&gt;hesperetin&gt;tangeretin&gt;nobiletin.	Flavonoids	133-143	beta-lactoglobulin	Bos taurus	92-95
24880994-4	2014	The molecular docking results revealed that these flavonoids bind in the internal cavity of BLG and the BLG affinity for binding the flavonoids follows naringenin&gt;hesperetin&gt;tangeretin&gt;nobiletin.	Flavonoids	133-143	beta-lactoglobulin	Bos taurus	104-107
24880994-5	2014	The docking results also indicated that the BLG-flavonoid complexes are stabilized through hydrophobic interactions, hydrogen bond interactions and pi-pi stacking interactions.	Flavonoids	48-57	beta-lactoglobulin	Bos taurus	44-47
24880994-7	2014	Time evolution of the radius of gyration, total solvent accessible surface of the protein and the second structure of protein showed as well that BLG and BLG-flavonoid complexes were stable around 2500ps, and there was not any conformational change as for BLG-flavonoid complexes.	Flavonoids	158-167	beta-lactoglobulin	Bos taurus	154-157
24880994-7	2014	Time evolution of the radius of gyration, total solvent accessible surface of the protein and the second structure of protein showed as well that BLG and BLG-flavonoid complexes were stable around 2500ps, and there was not any conformational change as for BLG-flavonoid complexes.	Flavonoids	158-167	beta-lactoglobulin	Bos taurus	154-157
24880994-7	2014	Time evolution of the radius of gyration, total solvent accessible surface of the protein and the second structure of protein showed as well that BLG and BLG-flavonoid complexes were stable around 2500ps, and there was not any conformational change as for BLG-flavonoid complexes.	Flavonoids	260-269	beta-lactoglobulin	Bos taurus	146-149
24880994-7	2014	Time evolution of the radius of gyration, total solvent accessible surface of the protein and the second structure of protein showed as well that BLG and BLG-flavonoid complexes were stable around 2500ps, and there was not any conformational change as for BLG-flavonoid complexes.	Flavonoids	260-269	beta-lactoglobulin	Bos taurus	154-157
24880994-7	2014	Time evolution of the radius of gyration, total solvent accessible surface of the protein and the second structure of protein showed as well that BLG and BLG-flavonoid complexes were stable around 2500ps, and there was not any conformational change as for BLG-flavonoid complexes.	Flavonoids	260-269	beta-lactoglobulin	Bos taurus	154-157
24901042-8	2014	As inhibitors of PI3K, flavonoids may potentially inhibit the PI3K/Akt-dependent activation of eNOS.	Flavonoids	23-33	AKT serine/threonine kinase 1	Homo sapiens	67-70
24901042-9	2014	(3) Under conditions of inflammation and oxidative stress, flavonoids may prevent the inflammatory signalling cascades via inhibition of NFkappaB and thereby downregulate iNOS.	Flavonoids	59-69	nuclear factor kappa B subunit 1	Homo sapiens	137-145
24901042-9	2014	(3) Under conditions of inflammation and oxidative stress, flavonoids may prevent the inflammatory signalling cascades via inhibition of NFkappaB and thereby downregulate iNOS.	Flavonoids	59-69	nitric oxide synthase 2	Homo sapiens	171-175
24768712-7	2014	Our results showed that flavonoids blocked activation of ERK, JNK, and p38 in cardiomyocytes treated with LTA.	Flavonoids	24-34	mitogen-activated protein kinase 1	Mus musculus	57-60
24768712-7	2014	Our results showed that flavonoids blocked activation of ERK, JNK, and p38 in cardiomyocytes treated with LTA.	Flavonoids	24-34	mitogen-activated protein kinase 8	Mus musculus	62-65
24768712-7	2014	Our results showed that flavonoids blocked activation of ERK, JNK, and p38 in cardiomyocytes treated with LTA.	Flavonoids	24-34	mitogen-activated protein kinase 14	Mus musculus	71-74
24768712-8	2014	Moreover, the flavonoids showed no cytotoxic effects and blocked NF-kappaB translocation and IkappaB degradation and inhibited LTA-induced NF-kappaB promoter activity, iNOS expression and NO production.	Flavonoids	14-24	nitric oxide synthase 2, inducible	Mus musculus	168-172
24881541-2	2014	In the present work, the interaction between our synthesized flavonoid derivative 3d (possessing potent antitumor activity against HepG2 cells) and HSA was investigated using fluorescence spectroscopy, circular dichroism spectroscopy, UV-vis spectroscopy and molecular modeling approach.	Flavonoids	61-70	albumin	Homo sapiens	148-151
23359392-4	2014	Our previous studies have demonstrated that the chemopreventive bioflavonoid apigenin inhibited hypoxia-induced elevation of VEGF production at low oxygen conditions characteristic for solid tumors.	Flavonoids	64-76	vascular endothelial growth factor A	Homo sapiens	125-129
24881541-10	2014	In conclusion, flavonoid derivative 3d can bind to HSA with noncovalent bond in a relatively stable way, so it can be delivered by HSA in a circulatory system.	Flavonoids	15-24	albumin	Homo sapiens	51-54
24881541-10	2014	In conclusion, flavonoid derivative 3d can bind to HSA with noncovalent bond in a relatively stable way, so it can be delivered by HSA in a circulatory system.	Flavonoids	15-24	albumin	Homo sapiens	131-134
25007066-7	2014	In this review, we discuss the role of flavonoids, a class of natural compounds, on Wnt/beta-catenin regulation and its possible potential for therapeutic usage on colorectal cancer.	Flavonoids	39-49	catenin beta 1	Homo sapiens	88-100
23883519-2	2014	However, previous studies have shown that a group of tea flavonoids, the catechins, are brain permeable and neuroprotective.	Flavonoids	57-67	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	53-56
25276204-0	2014	Comparative binding affinities of flavonoid phytochemicals with bovine serum albumin.	Flavonoids	34-43	albumin	Homo sapiens	71-84
25276204-3	2014	In the current work, the binding interactions of eight related flavonoids, sharing a similar core structure, with bovine serum albumin (BSA) were investigated by fluorescence spectroscopy.	Flavonoids	63-73	albumin	Homo sapiens	121-134
24753209-0	2014	A nondigestible saccharide, fructooligosaccharide, increases the promotive effect of a flavonoid, alpha-glucosyl-isoquercitrin, on glucagon-like peptide 1 (GLP-1) secretion in rat intestine and enteroendocrine cells.	Flavonoids	87-96	glucagon	Rattus norvegicus	131-154
24753209-0	2014	A nondigestible saccharide, fructooligosaccharide, increases the promotive effect of a flavonoid, alpha-glucosyl-isoquercitrin, on glucagon-like peptide 1 (GLP-1) secretion in rat intestine and enteroendocrine cells.	Flavonoids	87-96	glucagon	Rattus norvegicus	156-161
23024111-9	2014	Furthermore, both flavonoids increased HO-1 mRNA expression and decreased the elevated TNF-alpha level.	Flavonoids	18-28	heme oxygenase 1	Rattus norvegicus	39-43
23024111-9	2014	Furthermore, both flavonoids increased HO-1 mRNA expression and decreased the elevated TNF-alpha level.	Flavonoids	18-28	tumor necrosis factor	Rattus norvegicus	87-96
23024111-11	2014	Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF-alpha release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination.	Flavonoids	232-242	heme oxygenase 1	Rattus norvegicus	90-94
23024111-11	2014	Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF-alpha release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination.	Flavonoids	232-242	tumor necrosis factor	Rattus norvegicus	115-124
24794743-0	2014	Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.	Flavonoids	24-33	PC4 and SFRS1 interacting protein 1	Homo sapiens	129-132
24971999-4	2014	In addition to the well-known EGFR inhibitors gefitinib and erlotinib, the dietary flavonoid luteolin was a potent inhibitor of the Ser/Thr kinase activity of GAK in vitro.	Flavonoids	83-92	cyclin G associated kinase	Homo sapiens	159-162
24704474-1	2014	Chrysin (5,7-di-OH-flavone), a widely distributed natural flavonoid, has been well documented for involving in various biological activities, especially in regulation of peroxisome proliferator activated receptor gamma (PPARgamma) activity as a modest modulator.	Flavonoids	58-67	peroxisome proliferator activated receptor gamma	Mus musculus	220-229
24992765-0	2014	Total flavonoids from Ganshanbian (Herba Hyperici Attenuati) effect the expression of CaL-alpha1C and K(ATP)-Kir6.1 mRNA of the myocardial cell membrane in myocardial ischemia-reperfusion arrhythmia rats.	Flavonoids	6-16	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	109-115
24786574-10	2014	Moreover, the flavonoids and diarylheptanoids inhibited NO and TNF-alpha production in a dose dependent manner.	Flavonoids	14-24	tumor necrosis factor	Mus musculus	63-72
24959081-7	2014	Further studies revealed that total flavonoids significantly decreased the serum levels of transforming growth factor beta, prostaglandin E2, and cyclooxygenase 2 in tumor-bearing mice, which may be responsible for the inhibition of Tregs.	Flavonoids	36-46	prostaglandin-endoperoxide synthase 2	Mus musculus	146-162
25036175-0	2014	Drynaria total flavonoids decrease cathepsin K expression in ovariectomized rats.	Flavonoids	15-25	cathepsin K	Rattus norvegicus	35-46
25036175-8	2014	The total flavonoid and normal groups had significant differences in serum cathepsin K concentrations compared with that in the estrogen group (P&lt;0.05).	Flavonoids	10-19	cathepsin K	Rattus norvegicus	75-86
25036175-9	2014	The total flavonoid and sham-operated groups also showed significant differences in cathepsin K mRNA expression compared with that in the normal group (P&lt;0.01).	Flavonoids	10-19	cathepsin K	Rattus norvegicus	84-95
25036175-12	2014	Thus, Drynaria total flavonoids inhibited the serum cathepsin K concentration and increased the maximum bending load of the tibial shaft in ovariectomized rats.	Flavonoids	21-31	cathepsin K	Rattus norvegicus	52-63
24992765-1	2014	OBJECTIVE: To observe the impact of total flavonoids from Ganshanbian (Herba Hyperici Attenuati) on the expression of vascular smooth muscle membrane L-type calcium channel alpha1 C subunit (CaL-alpha1C) and ATP-sensitive K+ channel (K(ATP))-Kir6.1 mRNA, and explore the mechanisms of the antiarrhythmic effect of Ganshanbian (Herba Hyperici Attenuati) total flavonoids.	Flavonoids	42-52	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	242-248
24992765-5	2014	RESULTS: Total flavonoids from Ganshanbian (Herba Hyperici Attenuati) can delay the appearance of myocardial ischemia reperfusion arrhythmias, shorten the duration of myocardial ischemia reperfusion arrhythmias, reduce heart rate, reduce cell membrane expression of CaL-a1C mRNA and enhance the expression of K(ATP)-Kir6.1 mRNA in myocardial ischemia-reperfusion arrhythmic rats.	Flavonoids	15-25	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	316-322
24912635-0	2014	[Total flavonoids from Astragalus complanatus attenuates lung injury following paraquat poisoning in rats through inhibiting excessive endoplasmic reticulum stress and c-Jun N-terminal kinase pathway].	Flavonoids	7-17	mitogen-activated protein kinase 8	Rattus norvegicus	168-191
24722549-3	2014	The role of TRANSPARENT TESTA8 (TT8) in the regulation of flavonoid biosynthesis and the formation of seed coat color is extensively studied; however, its function in affecting seed FA biosynthesis is poorly understood.	Flavonoids	58-67	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	24-30
24722549-3	2014	The role of TRANSPARENT TESTA8 (TT8) in the regulation of flavonoid biosynthesis and the formation of seed coat color is extensively studied; however, its function in affecting seed FA biosynthesis is poorly understood.	Flavonoids	58-67	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	32-35
24687133-10	2014	Reduced glutathione prevented peroxynitrite-induced FeOxI drop, tyrosine nitration, and cysteine oxidation; flavonoid(-)-epicatechin, which prevented ceruloplasmin tyrosine nitration but not cysteine oxidation, partially impeded peroxynitrite-induced FeOxI drop.	Flavonoids	108-117	ceruloplasmin	Homo sapiens	150-163
25026697-3	2014	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-41
24846090-4	2014	In the present work, Arabidopsis MYB transcription factor, AtMYB111, has been expressed in tobacco to study whether this can enhance flavonoid biosynthesis in heterologous system.	Flavonoids	133-142	myb domain protein 111	Arabidopsis thaliana	59-67
24680994-14	2014	CONCLUSIONS: These findings suggest the protective effect of EEAR against CCl4 induced oxidative stress might be attributed to the presence of flavonoids and phenolic compounds.	Flavonoids	143-153	C-C motif chemokine ligand 4	Rattus norvegicus	74-78
24612139-2	2014	We investigated whether quercetin, a flavonoid, can sensitize human ovarian cancer cells to TRAIL.	Flavonoids	37-46	TNF superfamily member 10	Homo sapiens	92-97
24940409-0	2014	Total flavonoids from Plumula Nelumbinis suppress angiotensin II-induced fractalkine production by inhibiting the ROS/NF-kappaB pathway in human umbilical vein endothelial cells.	Flavonoids	6-16	angiotensinogen	Homo sapiens	50-64
24940409-0	2014	Total flavonoids from Plumula Nelumbinis suppress angiotensin II-induced fractalkine production by inhibiting the ROS/NF-kappaB pathway in human umbilical vein endothelial cells.	Flavonoids	6-16	C-X3-C motif chemokine ligand 1	Homo sapiens	73-84
24895476-0	2014	beta-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents.	Flavonoids	75-84	glucuronidase beta	Homo sapiens	0-18
24895476-7	2014	We propose that the extracellular activity of beta-glucuronidase associated with the status of the mitochondrial function in the target cells might be important biomarkers for the specific sites where the glucuronides of dietary flavonoids can act as anti-atherosclerotic and anti-inflammatory agents in vivo.	Flavonoids	229-239	glucuronidase beta	Homo sapiens	46-64
24375494-0	2014	Analysis of flavonoids regulating the expression of UGT1A1 via xenobiotic receptors in intestinal epithelial cells.	Flavonoids	12-22	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-58
24375494-3	2014	Experimental results confirmed that these flavonoids increased UGT1A protein expression as well as its enzymatic activity.	Flavonoids	42-52	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	63-68
24375494-7	2014	These results elucidate the molecular mechanism of flavonoid-induced UGT1A1 gene expression via xenobiotic receptors in the intestines.	Flavonoids	51-60	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
24940409-3	2014	In the study, we aimed to investigate the protective role of total flavonoids from Plumula Nelumbinis (TFPN), the main component extracted from Semen Nelumbinis, in Ang II-induced oxidative stress injury in human umbilical vein endothelial cells (HUVECs).	Flavonoids	67-77	angiotensinogen	Homo sapiens	165-171
24940409-5	2014	In the present study, it was observed that total flavonoids from Plumula Nelumbinis (TFPN), the main component extracted from Semen Nelumbinis, concentration-dependently inhibited the FKN production induced by Ang II in human umbilical vein endothelial cells (HUVECs).	Flavonoids	49-59	C-X3-C motif chemokine ligand 1	Homo sapiens	184-187
24940409-5	2014	In the present study, it was observed that total flavonoids from Plumula Nelumbinis (TFPN), the main component extracted from Semen Nelumbinis, concentration-dependently inhibited the FKN production induced by Ang II in human umbilical vein endothelial cells (HUVECs).	Flavonoids	49-59	angiogenin	Homo sapiens	210-213
24666416-3	2014	Previously, we have shown that wogonin, a flavonoid isolated from the root of Scutellaria baicalensis Georgi, could reverse drug resistance in MCF-7/DOX cells by blocking the translocation of Nrf2 into nucleus.	Flavonoids	42-51	NFE2 like bZIP transcription factor 2	Homo sapiens	192-196
24604735-9	2014	The expression of NtMYB305, an orthologue of MYB305 previously identified as a flavonoid metabolic regulator in Antirrhinum majus flowers and as a floral-nectar regulator mediating starch synthesis in ornamental tobacco, was extremely downregulated in NtCOI1-silenced tobacco.	Flavonoids	79-88	myb-related protein 305-like	Nicotiana tabacum	18-26
24604735-9	2014	The expression of NtMYB305, an orthologue of MYB305 previously identified as a flavonoid metabolic regulator in Antirrhinum majus flowers and as a floral-nectar regulator mediating starch synthesis in ornamental tobacco, was extremely downregulated in NtCOI1-silenced tobacco.	Flavonoids	79-88	myb-related protein 305-like	Nicotiana tabacum	20-26
24619996-0	2014	Modulation of flavonoid metabolites in Arabidopsis thaliana through overexpression of the MYB75 transcription factor: role of kaempferol-3,7-dirhamnoside in resistance to the specialist insect herbivore Pieris brassicae.	Flavonoids	14-23	production of anthocyanin pigment 1	Arabidopsis thaliana	90-95
24413416-3	2014	Under low levels of UV-B, plants overexpressing UVR8 are dwarfed with a reduced root development and accumulate more flavonoids compared to control plants.	Flavonoids	117-127	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	48-52
24413416-7	2014	Our data suggest that UVR8-mediated accumulation of flavonoid and possibly changes in auxin homeostasis are the underlying mechanism of the observed growth phenotypes and that UVR8 might have an important role for integrating plant growth and stress signals.	Flavonoids	52-61	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	22-26
25026697-3	2014	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-47
25026697-3	2014	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	progesterone receptor	Homo sapiens	72-93
25026697-3	2014	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	tumor protein p53	Homo sapiens	99-102
24400871-7	2014	Here, we identified Apigenin, a plant-derived flavonoid, as a reagent to further enhance the iodide influx rate increased by Akt inhibition in thyroid cells under acute TSH stimulation.	Flavonoids	46-55	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
24720993-0	2014	An automated sequential injection spectrophotometric method for evaluation of tyramine oxidase inhibitory activity of some flavonoids.	Flavonoids	123-133	monoamine oxidase B	Homo sapiens	78-94
24720993-5	2014	Under the optimum conditions: 1.0 mM tyramine, 8 U mL(-1) TOD, 1.0 mM vanillic acid, 1.0 mM 4-AA and delay time of 10 s, some flavonoid compounds were examined for the TOD inhibitory activity expressed as IC50 value.	Flavonoids	126-135	monoamine oxidase B	Homo sapiens	58-61
24720993-5	2014	Under the optimum conditions: 1.0 mM tyramine, 8 U mL(-1) TOD, 1.0 mM vanillic acid, 1.0 mM 4-AA and delay time of 10 s, some flavonoid compounds were examined for the TOD inhibitory activity expressed as IC50 value.	Flavonoids	126-135	monoamine oxidase B	Homo sapiens	168-171
24637017-3	2014	The flavonoid 7,8-dihydroxyflavone (7,8-DHF) is a potent and selective small molecule tyrosine kinase receptor B (TrkB) agonist that mimics the effects of BDNF.	Flavonoids	4-13	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	86-112
24637017-3	2014	The flavonoid 7,8-dihydroxyflavone (7,8-DHF) is a potent and selective small molecule tyrosine kinase receptor B (TrkB) agonist that mimics the effects of BDNF.	Flavonoids	4-13	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	114-118
24637017-3	2014	The flavonoid 7,8-dihydroxyflavone (7,8-DHF) is a potent and selective small molecule tyrosine kinase receptor B (TrkB) agonist that mimics the effects of BDNF.	Flavonoids	4-13	brain derived neurotrophic factor	Mus musculus	155-159
24530445-6	2014	This suggests that the ERp57-silibinin interaction might explain at least some of the biological effects caused by the flavonoid.	Flavonoids	119-128	protein disulfide isomerase family A member 3	Homo sapiens	23-28
24613626-2	2014	Despite a large number of structurally and functionally diverse compounds, also flavonoids and chalcones have been reported as inhibitors of P-gp.	Flavonoids	80-90	ATP binding cassette subfamily B member 1	Homo sapiens	141-145
24398107-6	2014	Moreover, flavonoids 1a and 2a processed procaspase-7 to the active caspase-7 both in yeast and in vitro processing assays, and inhibited the growth of HL-60 and MCF-7 human tumor cells with higher potencies than PAC-1, particularly in the absence of caspase-3 (MCF-7 cells).	Flavonoids	10-20	ADCYAP receptor type I	Homo sapiens	213-218
24398107-6	2014	Moreover, flavonoids 1a and 2a processed procaspase-7 to the active caspase-7 both in yeast and in vitro processing assays, and inhibited the growth of HL-60 and MCF-7 human tumor cells with higher potencies than PAC-1, particularly in the absence of caspase-3 (MCF-7 cells).	Flavonoids	10-20	caspase 3	Homo sapiens	251-260
24576254-0	2014	TNF-alpha inhibition elicited by mansoins A and B, heterotrimeric flavonoids isolated from Mansoa hirsuta.	Flavonoids	66-76	tumor necrosis factor	Homo sapiens	0-9
24722342-1	2014	Many (dietary) bitter compounds, e.g. flavonoids, activate bitter receptor hTAS2R39 in cell-based assays.	Flavonoids	38-48	taste 2 receptor member 39	Homo sapiens	75-83
24338263-5	2014	LOE contained high levels of polyphenols and flavonoids, which possess strong DPPH radical scavenging activity, and was shown to attenuate paraquat-induced oxidative damage and lethality in flies.	Flavonoids	45-55	SNF4/AMP-activated protein kinase gamma subunit	Drosophila melanogaster	0-3
24553666-12	2014	After co-incubation with both flavonoids, formation of EtG was significantly reduced for all enzymes except for UGT2B15, whose activity did not seem to be affected.	Flavonoids	30-40	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	112-119
24333331-0	2014	A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats.	Flavonoids	67-76	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	41-45
24444877-0	2014	Polyphenol compounds belonging to flavonoids inhibit activity of coagulation factor X.	Flavonoids	34-44	coagulation factor X	Homo sapiens	65-85
24444877-6	2014	We observed that only four polyphenols belonging to flavonoids group: procyanidin B2, cyanidin, quercetin and silybin, had inhibitory effect on FXa activity.	Flavonoids	52-62	coagulation factor X	Homo sapiens	144-147
24444877-8	2014	The results presented here showed that flavonoids might be potential structural bases for design of new nature-based, safe, orally bioavailable direct FXa inhibitors.	Flavonoids	39-49	coagulation factor X	Homo sapiens	151-154
26401351-2	2014	Enhancement of insulinotropic gut hormones by inhibition of dipeptidyl peptidase-IV (DPP-IV) are among the newest strategies for treatments of Type 2 diabetes which thought to be the underlying action through which flavonoid can reduce postprandial hyperglycemia.	Flavonoids	215-224	dipeptidylpeptidase 4	Rattus norvegicus	60-83
26401351-2	2014	Enhancement of insulinotropic gut hormones by inhibition of dipeptidyl peptidase-IV (DPP-IV) are among the newest strategies for treatments of Type 2 diabetes which thought to be the underlying action through which flavonoid can reduce postprandial hyperglycemia.	Flavonoids	215-224	dipeptidylpeptidase 4	Rattus norvegicus	85-91
24491314-4	2014	Quercetin, a natural flavonoid, has been reported to ameliorate high fructose-induced rat insulin resistance and hyperlipidemia.	Flavonoids	21-30	insulin	Homo sapiens	90-97
24333331-6	2014	We observed parallel increases in hippocampal NMDA receptors containing the NR2B subunit for both 8.7 mg/day (p &lt; 0.05) and 17.4 mg/day (p &lt; 0.001) doses, suggesting an enhancement of glutamate signaling following flavonoid intervention.	Flavonoids	220-229	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	76-80
24333331-8	2014	Collectively, the present data supports a new role for PSA-NCAM and NMDA-NR2B receptor on flavonoid-induced improvements in learning and memory, contributing further to the growing body of evidence suggesting beneficial effects of flavonoids in cognition and brain health.	Flavonoids	90-99	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	73-77
24741320-2	2014	Modulation of CYP3A4 by flavonoids, such as anthocyanins, has been shown to inhibit the mutagenic activity of mammalian cells.	Flavonoids	24-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20
24991101-0	2014	Molecular docking studies of flavonoids for their inhibition pattern against beta-catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for Wnt signaling pathway.	Flavonoids	29-39	catenin beta 1	Homo sapiens	77-89
24991101-4	2014	OBJECTIVE: Elucidation of the binding mode of inhibitors to beta-catenin, reporting more potent inhibitors for the disease-causing protein and designing a pharmacophore model based on naturally occurring compounds, flavonoids.	Flavonoids	215-225	catenin beta 1	Homo sapiens	60-72
24991101-9	2014	Moreover, flavonoid family members and T cell factors 4 (TCF4) compete for beta-catenin binding by sharing common binding residues.	Flavonoids	10-19	catenin beta 1	Homo sapiens	75-87
24991101-10	2014	CONCLUSION: This study will largely help in understanding the molecular basis of beta-catenin/TCF4 inhibition through flavonoids by exploring their structural details.	Flavonoids	118-128	catenin beta 1	Homo sapiens	81-93
24991101-10	2014	CONCLUSION: This study will largely help in understanding the molecular basis of beta-catenin/TCF4 inhibition through flavonoids by exploring their structural details.	Flavonoids	118-128	transcription factor 4	Homo sapiens	94-98
24362044-7	2014	The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.	Flavonoids	77-87	ATP binding cassette subfamily B member 1	Homo sapiens	34-48
24362044-7	2014	The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.	Flavonoids	77-87	ATP binding cassette subfamily B member 1	Homo sapiens	169-183
24485149-0	2014	The flavonoid-enriched fraction AF4 suppresses neuroinflammation and promotes restorative gene expression in a mouse model of experimental autoimmune encephalomyelitis.	Flavonoids	4-13	immunoglobulin kappa variable 4-80	Mus musculus	32-35
24566333-3	2014	The conjugated flavonoids were deconjugated by the enzyme beta-Glucuronidase and Sulfatase.	Flavonoids	15-25	glucuronidase, beta	Rattus norvegicus	58-76
24485149-1	2014	The anti-inflammatory and restorative effects of the flavonoid-enriched fraction AF4 were examined in a mouse model of experimental autoimmune encephalomyelitis (EAE).	Flavonoids	53-62	immunoglobulin kappa variable 4-80	Mus musculus	81-84
24319076-8	2014	Induction assays indicated that AtMYB7 represses several genes of the flavonoid pathway, DFR and UGT being early targets of this transcription factor.	Flavonoids	70-79	myb domain protein 7	Arabidopsis thaliana	32-38
23601990-0	2014	Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase.	Flavonoids	54-64	carboxyl ester lipase	Homo sapiens	103-123
23601990-1	2014	A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE).	Flavonoids	27-37	carboxyl ester lipase	Homo sapiens	109-129
23601990-1	2014	A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE).	Flavonoids	27-37	carboxyl ester lipase	Homo sapiens	131-136
23601990-1	2014	A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE).	Flavonoids	27-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-162
23601990-1	2014	A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE).	Flavonoids	27-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
23601990-2	2014	The results showed that most of the synthesized compounds exhibited nanomolar potency against CEase, much better than the parent flavonoids.	Flavonoids	129-139	carboxyl ester lipase	Homo sapiens	94-99
23601990-3	2014	Furthermore, these phosphorylated flavonoids demonstrated good to high selectivity for CEase over AChE, which only showed micromolar potency inhibition of AChE.	Flavonoids	34-44	carboxyl ester lipase	Homo sapiens	87-92
23601990-3	2014	Furthermore, these phosphorylated flavonoids demonstrated good to high selectivity for CEase over AChE, which only showed micromolar potency inhibition of AChE.	Flavonoids	34-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
23601990-3	2014	Furthermore, these phosphorylated flavonoids demonstrated good to high selectivity for CEase over AChE, which only showed micromolar potency inhibition of AChE.	Flavonoids	34-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
23601990-5	2014	The structure-activity relationships revealed that the free hydroxyl group at position 5 and phosphate group at position 7 of the phosphorylated flavonoids are favorable to the inhibition of CEase.	Flavonoids	145-155	carboxyl ester lipase	Homo sapiens	191-196
24431079-0	2014	Dietary flavonoids modulate CYP2C to improve drug oral bioavailability and their qualitative/quantitative structure-activity relationship.	Flavonoids	8-18	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	28-33
24431079-1	2014	This study aims to improve the drug oral bioavailability by co-administration with flavonoid inhibitors of the CYP2C isozyme and to establish qualitative and quantitative (QSAR) structure-activity relationships (SAR) between flavonoids and CYP2C.	Flavonoids	83-92	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	111-116
24431079-1	2014	This study aims to improve the drug oral bioavailability by co-administration with flavonoid inhibitors of the CYP2C isozyme and to establish qualitative and quantitative (QSAR) structure-activity relationships (SAR) between flavonoids and CYP2C.	Flavonoids	225-235	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	111-116
24431079-1	2014	This study aims to improve the drug oral bioavailability by co-administration with flavonoid inhibitors of the CYP2C isozyme and to establish qualitative and quantitative (QSAR) structure-activity relationships (SAR) between flavonoids and CYP2C.	Flavonoids	225-235	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	240-245
24431079-2	2014	A total of 40 naturally occurring flavonoids were screened in vitro for CYP2C inhibition.	Flavonoids	34-44	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	72-77
24431079-5	2014	The most effective flavonoid was orally co-administered in vivo with a cholesterol-reducing drug, fluvastatin, which is normally metabolized by CYP2C.	Flavonoids	19-28	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	144-149
24431079-8	2014	SAR analysis indicated that the presence of a 2,3-double bond in the C ring, hydroxylation at positions 5, 6, and 7, and glycosylation had important effects on flavonoid-CYP2C interactions.	Flavonoids	160-169	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	170-175
24431079-9	2014	These findings should prove useful for predicting the inhibition of CYP2C activity by other untested flavonoid-like compounds.	Flavonoids	101-110	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	68-73
24333668-2	2014	We conducted cell-based screening for IFN signaling enhancer and discovered that luteolin, a natural flavonoid, sensitized the antiproliferative effect of IFN-alpha in hepatoma HepG2 cells and cervical carcinoma HeLa cells.	Flavonoids	101-110	interferon alpha 1	Homo sapiens	155-164
24363289-2	2014	VvMYB5a and VvMYB5b are R2R3-MYB transcription factors previously proposed to control the spatiotemporal expression of flavonoid structural genes during berry development.	Flavonoids	119-128	MYB proto-oncogene, transcription factor	Homo sapiens	2-5
24602314-17	2014	Thus, mutants of the DFR2 gene have unique flavonoid compositions and display a wide variety of flower color patterns in soybean, from near white, light purple, dilute purple to pale.	Flavonoids	43-52	dihydroflavonol-4-reductase	Glycine max	21-25
24623967-10	2014	RESULTS: With the exception of EGCG, all flavonoids tested decreased dose-dependently the RPE cell proliferation, migration, and secretion of VEGF.	Flavonoids	41-51	vascular endothelial growth factor A	Homo sapiens	142-146
24623967-17	2014	Most flavonoids tested diminished the phosphorylation levels of extracellular signal-regulated kinases 1/2 and Akt proteins.	Flavonoids	5-15	mitogen-activated protein kinase 3	Homo sapiens	64-106
24623967-17	2014	Most flavonoids tested diminished the phosphorylation levels of extracellular signal-regulated kinases 1/2 and Akt proteins.	Flavonoids	5-15	AKT serine/threonine kinase 1	Homo sapiens	111-114
24569980-4	2014	Ingested flavonoids have been reported to directly affect the regulation of cyclooxygenase-2 (COX-2) expression induced by bacterial toxins.	Flavonoids	9-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	76-92
24569980-4	2014	Ingested flavonoids have been reported to directly affect the regulation of cyclooxygenase-2 (COX-2) expression induced by bacterial toxins.	Flavonoids	9-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	94-99
24569980-5	2014	In this study, we examined the effects of four flavonoids (luteolin, fisetin, morin and myricetin) on the activation of ERK1/2, p38 and AKT, and on the synthesis of COX-2 in human gingival fibroblasts treated with LTA from Streptococcus sanguinis.	Flavonoids	47-57	mitogen-activated protein kinase 3	Homo sapiens	120-126
24569980-5	2014	In this study, we examined the effects of four flavonoids (luteolin, fisetin, morin and myricetin) on the activation of ERK1/2, p38 and AKT, and on the synthesis of COX-2 in human gingival fibroblasts treated with LTA from Streptococcus sanguinis.	Flavonoids	47-57	mitogen-activated protein kinase 1	Homo sapiens	128-131
24569980-5	2014	In this study, we examined the effects of four flavonoids (luteolin, fisetin, morin and myricetin) on the activation of ERK1/2, p38 and AKT, and on the synthesis of COX-2 in human gingival fibroblasts treated with LTA from Streptococcus sanguinis.	Flavonoids	47-57	AKT serine/threonine kinase 1	Homo sapiens	136-139
24287141-1	2014	Here we describe a novel strategy for mitigation of ionizing radiation-induced hematopoietic syndrome by suppressing the activity of MKP3, resulting in ERK activation and enhanced abundance of hematopoietic stem cells, using the antioxidant flavonoid baicalein (5,6,7-trihydroxyflavone).	Flavonoids	241-250	dual specificity phosphatase 6	Mus musculus	133-137
24287141-1	2014	Here we describe a novel strategy for mitigation of ionizing radiation-induced hematopoietic syndrome by suppressing the activity of MKP3, resulting in ERK activation and enhanced abundance of hematopoietic stem cells, using the antioxidant flavonoid baicalein (5,6,7-trihydroxyflavone).	Flavonoids	241-250	mitogen-activated protein kinase 1	Mus musculus	152-155
24532452-3	2014	This work describes a new phenotype for the nrt2.7-2 mutant allele in the Wassilewskija accession, which exhibited a distinctive pale-brown seed coat that is usually associated with a defect in flavonoid oxidation.	Flavonoids	194-203	nitrate transporter 2:1	Arabidopsis thaliana	44-48
24532452-4	2014	Indeed, this phenotype resembled those of tt10 mutant seeds defective in the laccase-like enzyme TT10/LAC15, which is involved in the oxidative polymerization of flavonoids such as the proantocyanidins (PAs) (i.e. epicatechin monomers and PA oligomers) and flavonol glycosides.	Flavonoids	162-172	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	42-46
24532452-4	2014	Indeed, this phenotype resembled those of tt10 mutant seeds defective in the laccase-like enzyme TT10/LAC15, which is involved in the oxidative polymerization of flavonoids such as the proantocyanidins (PAs) (i.e. epicatechin monomers and PA oligomers) and flavonol glycosides.	Flavonoids	162-172	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	97-101
24532452-4	2014	Indeed, this phenotype resembled those of tt10 mutant seeds defective in the laccase-like enzyme TT10/LAC15, which is involved in the oxidative polymerization of flavonoids such as the proantocyanidins (PAs) (i.e. epicatechin monomers and PA oligomers) and flavonol glycosides.	Flavonoids	162-172	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	102-107
24424324-4	2014	We demonstrate that Af encodes an isoform (SlCHI1) of the flavonoid biosynthetic enzyme chalcone isomerase (CHI), which catalyzes the conversion of naringenin chalcone to naringenin and is strictly required for flavonoid production in multiple tissues of tomato.	Flavonoids	58-67	chalcone--flavonone isomerase	Solanum lycopersicum	43-49
24424324-4	2014	We demonstrate that Af encodes an isoform (SlCHI1) of the flavonoid biosynthetic enzyme chalcone isomerase (CHI), which catalyzes the conversion of naringenin chalcone to naringenin and is strictly required for flavonoid production in multiple tissues of tomato.	Flavonoids	211-220	chalcone--flavonone isomerase	Solanum lycopersicum	43-49
24424324-7	2014	Our results establish a key role for SlCHI1 in flavonoid production in tomato and reveal a link between CHI1 and terpenoid production.	Flavonoids	47-56	chalcone--flavonone isomerase	Solanum lycopersicum	37-43
24424324-7	2014	Our results establish a key role for SlCHI1 in flavonoid production in tomato and reveal a link between CHI1 and terpenoid production.	Flavonoids	47-56	chalcone--flavonone isomerase	Solanum lycopersicum	39-43
25007586-1	2014	Anthocyanins are a ubiquitous group of water-soluble plant pigments of the flavonoid family, with anticancer property through HER-2 signaling pathway.	Flavonoids	75-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	126-131
24328060-3	2014	Experimental evidence supports the hypothesis that certain flavonoids may protect against Alzheimer"s disease in part by interfering with the generation and assembly of amyloid-beta peptides into neurotoxic oligomeric aggregates and also by reducing tau aggregation.	Flavonoids	59-69	amyloid beta precursor protein	Homo sapiens	169-181
24328060-3	2014	Experimental evidence supports the hypothesis that certain flavonoids may protect against Alzheimer"s disease in part by interfering with the generation and assembly of amyloid-beta peptides into neurotoxic oligomeric aggregates and also by reducing tau aggregation.	Flavonoids	59-69	microtubule associated protein tau	Homo sapiens	250-253
24128460-1	2014	Several studies have demonstrated that tea flavonoids protect cells and tissues against free radicals which have been implicated in the etiology of oxidative stress-related disease disorders.	Flavonoids	43-53	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	39-42
25204184-0	2014	[Study on structure-activity relationship of flavonoids" multidrug resistance-associated protein inhibitory activity].	Flavonoids	45-55	ATP binding cassette subfamily C member 3	Homo sapiens	57-96
25204184-1	2014	To study the quantitative structure-activity relationship (QSAR) between the stuctures of 29 flavonoids and the inhibitory activity of their multidrug resistance-associated protein (MRP) 1 and 2 by using the comparative molecular similarity index analysis (CoMSIA).	Flavonoids	93-103	ATP binding cassette subfamily C member 1	Homo sapiens	141-194
25204184-2	2014	By studying the impact of the combination of different molecular force fields, researchers obtained the molecular force fields that played an important role in inhibiting the activity of MRP1 and MRP2, built the optimized QSAR model, and discussed the structural modification method for flavonoids" multidrug resistance-associated protein inhibitor.	Flavonoids	287-297	ATP binding cassette subfamily C member 1	Homo sapiens	187-191
25204184-2	2014	By studying the impact of the combination of different molecular force fields, researchers obtained the molecular force fields that played an important role in inhibiting the activity of MRP1 and MRP2, built the optimized QSAR model, and discussed the structural modification method for flavonoids" multidrug resistance-associated protein inhibitor.	Flavonoids	287-297	ATP binding cassette subfamily C member 2	Homo sapiens	196-200
25204184-2	2014	By studying the impact of the combination of different molecular force fields, researchers obtained the molecular force fields that played an important role in inhibiting the activity of MRP1 and MRP2, built the optimized QSAR model, and discussed the structural modification method for flavonoids" multidrug resistance-associated protein inhibitor.	Flavonoids	287-297	ATP binding cassette subfamily C member 3	Homo sapiens	299-338
25204184-3	2014	The results of the study could not only provide the guidance for new drug R&amp;D, but also help partially discuss the synergy mechanism between MRP1 and MRP2 receptors and traditional Chinese medicines containing flavonoids.	Flavonoids	214-224	ATP binding cassette subfamily C member 1	Homo sapiens	145-149
25204184-3	2014	The results of the study could not only provide the guidance for new drug R&amp;D, but also help partially discuss the synergy mechanism between MRP1 and MRP2 receptors and traditional Chinese medicines containing flavonoids.	Flavonoids	214-224	ATP binding cassette subfamily C member 2	Homo sapiens	154-158
25204186-1	2014	OBJECTIVE: To observe the effect of total flavonoids of Oldenlendia difflusa (FOD) on NF-kappaB and IL-8, TNF-alpha, IL-10 expressions of ulcerative colitis (UC) model rats, and explore its immunological mechanism of anti-UC.	Flavonoids	42-52	chemokine (C-X-C motif) ligand 15	Mus musculus	100-104
25204186-1	2014	OBJECTIVE: To observe the effect of total flavonoids of Oldenlendia difflusa (FOD) on NF-kappaB and IL-8, TNF-alpha, IL-10 expressions of ulcerative colitis (UC) model rats, and explore its immunological mechanism of anti-UC.	Flavonoids	42-52	interleukin 10	Rattus norvegicus	117-122
24333126-5	2014	A combination of the three flavonoids at 50 mug mL-1 almost completely inhibited crystallization, reducing the yield by 98%.	Flavonoids	27-37	L1 cell adhesion molecule	Mus musculus	48-52
24374359-0	2014	LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells.	Flavonoids	28-37	thioredoxin	Homo sapiens	94-99
24514562-5	2014	However, it seems that kaempferol, a flavonoid, contributes mainly to the MPO inhibition.	Flavonoids	37-46	myeloperoxidase	Homo sapiens	74-77
24238016-0	2014	Related flavonoids cause cooperative inhibition of the sarcoplasmic reticulum Ca2+ ATPase by multimode mechanisms.	Flavonoids	8-18	carbonic anhydrase 2	Homo sapiens	78-89
24206113-0	2014	A genetic algorithm- back propagation artificial neural network model to quantify the affinity of flavonoids toward P-glycoprotein.	Flavonoids	98-108	ATP binding cassette subfamily B member 1	Homo sapiens	116-130
24206113-1	2014	Flavonoids, the most diverse class of plant secondary metabolites, exhibit high affinity toward the purified cytosolic NBD2(C-terminal nucleotide-binding domain) of P-glycoprotein (P-gp).	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	165-179
24206113-1	2014	Flavonoids, the most diverse class of plant secondary metabolites, exhibit high affinity toward the purified cytosolic NBD2(C-terminal nucleotide-binding domain) of P-glycoprotein (P-gp).	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	181-185
24206113-2	2014	To explore the affinity of flavonoids for P-gp, quantitative structure-activity relationships (QSARs) models were developed using back-propagation artificial neural networks (BPANN) and multiple linear regression (MLR).	Flavonoids	27-37	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
24206113-5	2014	While BPANN models exceeded significantly MLR in predictable performance for their flexible characters, could be used to predict the affinity of flavonoids for P-gp and applied in further drug screening.	Flavonoids	145-155	ATP binding cassette subfamily B member 1	Homo sapiens	160-164
23709168-6	2014	In addition, these flavonoids attenuated SCF-induced proliferation of human primary melanocytes without toxicity and suppressed ultraviolet (UV) B irradiation-mediated melanin synthesis significantly.	Flavonoids	19-29	KIT ligand	Homo sapiens	41-44
23709168-7	2014	Among the active flavonoids, diosmetin was found to inhibit SCF-induced melanogenesis in a human melanoderm model.	Flavonoids	17-27	KIT ligand	Homo sapiens	60-63
24238016-7	2014	All three flavonoids stabilized the ATPase in the E1 conformation and reduced [32P]-ATP binding.	Flavonoids	10-20	dynein axonemal heavy chain 8	Homo sapiens	36-42
24353343-3	2014	Compared with the RG diet, the MYB10 diet contained elevated concentrations of the flavonoid subclasses anthocyanins, flavanol monomers (epicatechin) and oligomers (procyanidin B2), and flavonols (quercetin glycosides), but other plant secondary metabolites were largely unaltered.	Flavonoids	83-92	transcription factor MYB113-like	Malus domestica	31-36
24262486-0	2014	Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells.	Flavonoids	6-16	insulin	Homo sapiens	48-55
23356333-4	2014	This approach, which determines the reducing capacity of tested compounds directly, has previously been used for the determination of SARs of flavonoids, but has not been used for SAR determination of coumarins.	Flavonoids	142-152	sarcosine dehydrogenase	Homo sapiens	134-137
24381065-4	2014	Application of dexamethasone to these plants greatly alleviates the dwarfism and sterility and substantially reverses the biochemical phenotypes of ref8 plants, including the reduction of lignin content and hyperaccumulation of flavonoids and p-coumarate esters.	Flavonoids	228-238	cytochrome P450, family 98, subfamily A, polypeptide 3	Arabidopsis thaliana	148-152
24124108-11	2014	CONCLUSION: The outcomes of this study represent a significant contribution to the current understanding on the preventive mechanisms of quercetin during the early stages of liver cancer development, demonstrating that in addition to its known proapoptotic characteristics, the flavonoid modulates the expression of critical cell cycle regulators and peroxisome proliferator activated receptor-alpha activity.	Flavonoids	278-287	peroxisome proliferator activated receptor alpha	Rattus norvegicus	351-399
24317580-3	2014	In vitro ELISA assay suggested that the flavonoids have inhibitory effects on PARP activity, but glucosyl modifications reduced the inhibitory effect.	Flavonoids	40-50	poly [ADP-ribose] polymerase 1	Cricetulus griseus	78-82
24317580-4	2014	Cytotoxicity tests of Chinese hamster cells defective in BRCA2 gene (V-C8) and its parental V79 cells showed BRCA2-dependent synthetic lethality when treated with the flavonoids.	Flavonoids	167-177	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	57-62
24317580-4	2014	Cytotoxicity tests of Chinese hamster cells defective in BRCA2 gene (V-C8) and its parental V79 cells showed BRCA2-dependent synthetic lethality when treated with the flavonoids.	Flavonoids	167-177	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	109-114
24317580-5	2014	BRCA2 mutated cells were three times more sensitive to the flavonoids than the wild-type and gene complemented cells.	Flavonoids	59-69	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	0-5
24317580-7	2014	The present study provides support for the clinical use of new treatment drugs, and is the beginning of the potential application of flavonoids in cancer prevention and the periodic consumption of appropriate flavonoids to reduce cancer risk in individuals carrying a mutant allele of the BRCA2 gene.	Flavonoids	133-143	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	289-294
24317580-7	2014	The present study provides support for the clinical use of new treatment drugs, and is the beginning of the potential application of flavonoids in cancer prevention and the periodic consumption of appropriate flavonoids to reduce cancer risk in individuals carrying a mutant allele of the BRCA2 gene.	Flavonoids	209-219	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	289-294
24247234-3	2014	The genome search from BRAD data for the presence of flavonoid genes in B. rapa identified three candidate genes namely, DFR, TT1 and TT8 in the LG A9.	Flavonoids	53-62	dihydroflavonol 4-reductase	Brassica rapa	121-124
24247234-3	2014	The genome search from BRAD data for the presence of flavonoid genes in B. rapa identified three candidate genes namely, DFR, TT1 and TT8 in the LG A9.	Flavonoids	53-62	transcription factor TT8	Brassica rapa	134-137
24466041-6	2014	Consistent with monomeric composition, the transcript levels of flavonoid 3", 5"-hydroxylase and leucoanthocyanidin reductase in cotton fiber were much higher than their competing enzymes acting on the same substrates (dihydroflavonol 4-reductase and anthocyanidin synthase, respectively).	Flavonoids	64-73	putative anthocyanidin reductase	Gossypium hirsutum	219-246
24368208-0	2014	Inhibition of LOX by flavonoids: a structure-activity relationship study.	Flavonoids	21-31	seed linoleate 9S-lipoxygenase-3	Glycine max	14-17
24368208-4	2014	Thus antioxidants, such as flavonoids, capable of inhibiting lipid peroxidation and scavenging free radicals, may act as LOX inhibitors.	Flavonoids	27-37	seed linoleate 9S-lipoxygenase-3	Glycine max	121-124
24368208-5	2014	The aim of this work was to assess the structure-activity relationship among a series of flavonoids concerning 5-LOX inhibition, through a systematic study of the inhibition of the formation of LTB4 in human neutrophils.	Flavonoids	89-99	seed linoleate 9S-lipoxygenase-3	Glycine max	113-116
24368208-6	2014	The type of inhibition of the flavonoids was further studied using soybean LOX, type I, and Saturation Transfer Difference (1)H NMR (STD-(1)H NMR) was used to characterize the binding epitopes of the compounds to LOX-1.	Flavonoids	30-40	seed linoleate 9S-lipoxygenase-3	Glycine max	75-78
24368208-6	2014	The type of inhibition of the flavonoids was further studied using soybean LOX, type I, and Saturation Transfer Difference (1)H NMR (STD-(1)H NMR) was used to characterize the binding epitopes of the compounds to LOX-1.	Flavonoids	30-40	seed linoleate 9S-lipoxygenase-3	Glycine max	213-216
24466041-6	2014	Consistent with monomeric composition, the transcript levels of flavonoid 3", 5"-hydroxylase and leucoanthocyanidin reductase in cotton fiber were much higher than their competing enzymes acting on the same substrates (dihydroflavonol 4-reductase and anthocyanidin synthase, respectively).	Flavonoids	64-73	leucoanthocyanidin dioxygenase-like	Gossypium hirsutum	251-273
24500009-0	2014	A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways.	Flavonoids	9-18	interleukin 6	Homo sapiens	88-101
24707875-4	2014	The proteomics results showed that AP-4, ARID 5B, HNRNP K, PLOG, Prdx6, and myosin-1, associated with cell growth, differentiation and development, and overexpressed in gastric cancer, colorectal cancer, pancreatic cancer, etc., were statistically down-regulated after the flavonoids treatment.	Flavonoids	273-283	transcription factor AP-4	Homo sapiens	35-39
24354565-6	2014	Our QM/MM computations also confirmed that these two flavonoids have lower reaction energetic barriers for COMT-catalyzed meta-O-methylation than para-O-methylation.	Flavonoids	53-63	catechol-O-methyltransferase	Homo sapiens	107-111
25004882-0	2014	Flavonoids from Litsea coreana decreases TNF-alpha secretion from peritoneal macrophages in adjuvant-induced arthritis rats via UPR pathway.	Flavonoids	0-10	tumor necrosis factor	Rattus norvegicus	41-50
25169908-1	2014	Chrysin and luteolin are two flavonoids with Peroxisome proliferators-activated receptor gamma (PPAR-gamma) stimulating activity.	Flavonoids	29-39	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	45-94
25169908-1	2014	Chrysin and luteolin are two flavonoids with Peroxisome proliferators-activated receptor gamma (PPAR-gamma) stimulating activity.	Flavonoids	29-39	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	96-106
25040994-3	2014	At physiological concentrations, luteolin as a flavonoid compound can inhibit Nrf2 and sensitize cancer cells to chemotherapeutic agents.	Flavonoids	47-56	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
24389490-1	2014	We aimed to identify a novel flavonoid from the in-house natural products to suppress matrix metalloproteases (MMPs), which is responsible for degradation of collagen and other extracellular matrix proteins.	Flavonoids	29-38	matrix metallopeptidase 9	Homo sapiens	111-115
24500009-0	2014	A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways.	Flavonoids	9-18	ALK receptor tyrosine kinase	Homo sapiens	127-153
24389490-4	2014	Furthermore, three representative flavonoids in this active extract of Citrus unshiu peel were tested in MMP-9 reporter system.	Flavonoids	34-44	matrix metallopeptidase 9	Homo sapiens	105-110
24389490-5	2014	Nobiletin (NB) of the tested flavonoids suppressed MMP-9 expression without cytotoxicity, which was validated by both real-time polymerase chain reaction (PCR) and zymography analyses.	Flavonoids	29-39	matrix metallopeptidase 9	Homo sapiens	51-56
24789998-3	2014	In the present study, we investigated how inhibition of Abeta fibril formation by this flavonoid affects Abeta conformation and neurotoxicity.	Flavonoids	87-96	amyloid beta precursor protein	Rattus norvegicus	56-61
24083611-6	2014	In the same way, CYP1-activatied prodrugs are categorized into four groups: benzothiazoles, flavonoids, stilbenes and alkylating agents.	Flavonoids	92-102	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	17-21
24789998-3	2014	In the present study, we investigated how inhibition of Abeta fibril formation by this flavonoid affects Abeta conformation and neurotoxicity.	Flavonoids	87-96	amyloid beta precursor protein	Rattus norvegicus	105-110
24995310-10	2014	IMF-8 significantly increased the catalase and GSH levels whereas it reduced the TNF- alpha and IL-6 levels markedly which suggests the antioxidative and anti-inflammatory actions of flavonoids present in IMF-8.	Flavonoids	183-193	tumor necrosis factor	Rattus norvegicus	81-91
24995310-10	2014	IMF-8 significantly increased the catalase and GSH levels whereas it reduced the TNF- alpha and IL-6 levels markedly which suggests the antioxidative and anti-inflammatory actions of flavonoids present in IMF-8.	Flavonoids	183-193	interleukin 6	Rattus norvegicus	96-100
25756670-0	2014	Molecular factors influencing the affinity of flavonoid compounds on P-glycoprotein efflux transporter.	Flavonoids	46-55	ATP binding cassette subfamily B member 1	Homo sapiens	69-83
25756670-6	2014	The interactions between flavonoids and Pgp have also been extensively studied and some quantitative structure-activity relationships (QSAR) have been reported.	Flavonoids	25-35	ATP binding cassette subfamily B member 1	Homo sapiens	40-43
25756670-7	2014	In the present work, we have employed 2D-QSAR analysis to evaluate the interactions between Pgp and several flavonoid compounds with the aim of identifying the molecular factors responsible for the Pgp-binding affinity evidenced by these compounds.	Flavonoids	108-117	ATP binding cassette subfamily B member 1	Homo sapiens	92-95
25756670-7	2014	In the present work, we have employed 2D-QSAR analysis to evaluate the interactions between Pgp and several flavonoid compounds with the aim of identifying the molecular factors responsible for the Pgp-binding affinity evidenced by these compounds.	Flavonoids	108-117	ATP binding cassette subfamily B member 1	Homo sapiens	198-201
25756670-8	2014	Thus, the reported data for dissociation constants (KD) between Pgp and 62 flavonoid compounds were modeled by means of multiple regression analysis (MLR), and structures of the compounds under study were characterized by means of calculated physicochemical properties and several topological and constitutional descriptors, as well as geometrical and quantum chemical indexes.	Flavonoids	75-84	ATP binding cassette subfamily B member 1	Homo sapiens	64-67
24789998-7	2014	Furthermore, a neurotoxicity assay with cultured rat hippocampal neurons demonstrated that Abeta incubated with 3,3",4",5"-tetrahydroxyflavone was significantly less toxic than Abeta incubated without the flavonoid.	Flavonoids	205-214	amyloid beta precursor protein	Rattus norvegicus	91-96
24083611-5	2014	According to their structural features, CYP1 inhibitors are divided into the following categories: flavonoids, trans-stilbenes, coumarins, terpenoids, alkaloids, quinones, isothiocyanates and synthetic aromatics.	Flavonoids	99-109	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	40-44
24588554-10	2014	Third, the coupling of transporters (such as BCRP and MRPs) and phase II enzymes (UGTs and SULTs) plays an important role in the disposition of flavonoids, especially in the enteroenteric and enterohepatic circulations.	Flavonoids	144-154	BCR pseudogene 1	Homo sapiens	45-49
24588554-7	2014	Second, phase II metabolic enzymes (UGTs, SULTs and COMT) dominate the metabolism of flavonoids in vivo.	Flavonoids	85-95	catechol-O-methyltransferase	Homo sapiens	52-56
24479689-6	2014	Moreover, an integrated in silico approach for the prediction of Phase I metabolism of the flavonoids quercetin, rutin, naringenin and naringin, which provided useful information about the most likely metabolites of these flavonoids and their interactions with amino acid residues of CYP2C9, is described.	Flavonoids	91-101	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	284-290
24529726-4	2014	Biochemical, molecular, and genetic studies have begun to reveal functions of a handful of ATP-binding cassette and multidrug and toxic compound extrusion family transporters engaged in transport of organic xenobiotics, heavy metals, metalloids, aluminum, alkaloids, flavonoids, terpenoids, terpenoid-derived phytohormones, cuticle lipids, and monolignols in plants.	Flavonoids	267-277	ATPase phospholipid transporting 8A2	Homo sapiens	91-94
24479689-6	2014	Moreover, an integrated in silico approach for the prediction of Phase I metabolism of the flavonoids quercetin, rutin, naringenin and naringin, which provided useful information about the most likely metabolites of these flavonoids and their interactions with amino acid residues of CYP2C9, is described.	Flavonoids	222-232	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	284-290
24588554-6	2014	First, lactase-phlorizin hydrolase (LPH) and human intestinal microflora mediate the hydrolysis of flavonoid glycosides, which is recognized as the first and determinant step in the absorption of flavonoids.	Flavonoids	196-206	lactase	Homo sapiens	7-34
24588554-6	2014	First, lactase-phlorizin hydrolase (LPH) and human intestinal microflora mediate the hydrolysis of flavonoid glycosides, which is recognized as the first and determinant step in the absorption of flavonoids.	Flavonoids	196-206	lactase	Homo sapiens	36-39
23701574-4	2014	Flavonoids inhibit the activation of mast cells and basophils and therefore suppress the release of chemical mediators, synthesis of Th2 type cytokines such as interleukin (IL)-4 and IL-13, and CD40 ligand expression, They also reportedly inhibit IL-4-induced signal transduction and affect the differentiation process of naive CD4+ T cells into effector T cell subsets.	Flavonoids	0-10	CD40 molecule	Homo sapiens	194-198
23701574-4	2014	Flavonoids inhibit the activation of mast cells and basophils and therefore suppress the release of chemical mediators, synthesis of Th2 type cytokines such as interleukin (IL)-4 and IL-13, and CD40 ligand expression, They also reportedly inhibit IL-4-induced signal transduction and affect the differentiation process of naive CD4+ T cells into effector T cell subsets.	Flavonoids	0-10	interleukin 4	Homo sapiens	247-251
25312618-0	2014	Implications of some selected flavonoids towards Alzheimer"s disease with the emphasis on cholinesterase inhibition and their bioproduction by metabolic engineering.	Flavonoids	30-40	butyrylcholinesterase	Homo sapiens	90-104
25312618-2	2014	Many flavonoid derivatives have been reported to possess neuroprotective activity through different mechanisms of action and, among them, cholinesterase (ChE) inhibition constitutes an important clinically applied treatment strategy of Alzheimer"s disease (AD).	Flavonoids	5-14	butyrylcholinesterase	Homo sapiens	138-152
25312618-2	2014	Many flavonoid derivatives have been reported to possess neuroprotective activity through different mechanisms of action and, among them, cholinesterase (ChE) inhibition constitutes an important clinically applied treatment strategy of Alzheimer"s disease (AD).	Flavonoids	5-14	butyrylcholinesterase	Homo sapiens	154-157
25312618-3	2014	Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD.	Flavonoids	5-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-86
25312618-3	2014	Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD.	Flavonoids	5-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	88-92
25312618-3	2014	Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD.	Flavonoids	5-14	butyrylcholinesterase	Homo sapiens	98-119
25312618-3	2014	Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD.	Flavonoids	5-14	butyrylcholinesterase	Homo sapiens	121-125
25312618-6	2014	In the current review, some common flavonoids with ChE inhibitory effect as well as the examples of flavonoids obtained from metabolic engineering methods will be discussed.	Flavonoids	35-45	butyrylcholinesterase	Homo sapiens	51-54
25383082-4	2014	The results showed that in vitro propolis flavonoids liposome can significantly enhance the phagocytic function of macrophages and the release of IL-1beta, IL-6, and IFN-gamma.	Flavonoids	42-52	interleukin 1 beta	Mus musculus	146-154
25383082-4	2014	The results showed that in vitro propolis flavonoids liposome can significantly enhance the phagocytic function of macrophages and the release of IL-1beta, IL-6, and IFN-gamma.	Flavonoids	42-52	interleukin 6	Mus musculus	156-160
25383082-4	2014	The results showed that in vitro propolis flavonoids liposome can significantly enhance the phagocytic function of macrophages and the release of IL-1beta, IL-6, and IFN-gamma.	Flavonoids	42-52	interferon gamma	Mus musculus	166-175
24533936-5	2014	A similar protective effect was also achieved with a dietary bioflavonoid quercetin that inhibits TG2 and beta-catenin signaling.	Flavonoids	61-73	transglutaminase 2	Homo sapiens	98-101
24533936-5	2014	A similar protective effect was also achieved with a dietary bioflavonoid quercetin that inhibits TG2 and beta-catenin signaling.	Flavonoids	61-73	catenin beta 1	Homo sapiens	106-118
24853561-0	2014	Flavonoid derivatives as potent tyrosinase inhibitors - a survey of recent findings between 2008-2013.	Flavonoids	0-9	tyrosinase	Homo sapiens	32-42
24853561-5	2014	Among them, many flavonoid derivatives have been revealed to be the strong inhibitors of tyrosinase.	Flavonoids	17-26	tyrosinase	Homo sapiens	89-99
24853561-6	2014	In this review, we reviewed many examples of tyrosinase inhibitors with flavonoid structure reported between 2008-2013.	Flavonoids	72-81	tyrosinase	Homo sapiens	45-55
24853561-7	2014	Our findings underline that flavonoids should continue to be the focus of tyrosinase inhibition studies as the promising compounds.	Flavonoids	28-38	tyrosinase	Homo sapiens	74-84
24710726-5	2014	In conclusion, enhanced UV-B radiation caused the increase in the flavonoid synthesis by promoting the activities of PAL, C4H, 4CL, and CHS in soybean seedlings.	Flavonoids	66-75	trans-cinnamate 4-monooxygenase	Glycine max	122-125
24710726-6	2014	The treatment of LaCl3 could change flavonoid synthesis in soybean seedlings under enhanced UV-B radiation by regulating the activities of PAL, C4H, 4CL, and CHS, which is an enzymological mechanism for the regulation of LaCl3 on flavonoid synthesis in plants under enhanced UV-B radiation.	Flavonoids	36-45	trans-cinnamate 4-monooxygenase	Glycine max	144-147
24710726-6	2014	The treatment of LaCl3 could change flavonoid synthesis in soybean seedlings under enhanced UV-B radiation by regulating the activities of PAL, C4H, 4CL, and CHS, which is an enzymological mechanism for the regulation of LaCl3 on flavonoid synthesis in plants under enhanced UV-B radiation.	Flavonoids	230-239	trans-cinnamate 4-monooxygenase	Glycine max	144-147
24878734-0	2014	P56(lck) kinase inhibitor studies: a 3D QSAR approach towards designing new drugs from flavonoid derivatives.	Flavonoids	87-96	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
24878734-1	2014	Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) based on 3D-QSAR (3D-quantitative structure activity relationship) studies were carried out on 97 flavonoid derivatives as potent P56(lck) protein tyrosine kinase inhibitors.	Flavonoids	206-215	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	238-246
24878734-4	2014	The resulting CoMFA and CoMSIA contour maps were used to identify the structural features relevant to the biological activity in this series of flavonoid derivatives, based upon which we identified and designed 10 novel molecules that showed superior inhibitory activity against P56(lck) protein which shed new light on effective therapeutic agents against these classes of enzymes.	Flavonoids	144-153	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	279-287
24551817-0	2014	Low Concentrations of Flavonoid - Rich Fraction of Shallot Extract Induce Delayed - Type Hypersensitivity and TH1 Cytokine IFNgamma Expression in BALB/c Mice.	Flavonoids	22-31	negative elongation factor complex member C/D, Th1l	Mus musculus	110-113
24176923-4	2014	In this work we tested the ability of the flavonoid (-)-epicatechin to regenerate this enzymatic activity both in vitro at the isolated MPO-H2O2-Cl(-) system and ex vivo in human PMNs.	Flavonoids	42-51	myeloperoxidase	Homo sapiens	136-139
23815082-2	2014	Serum albumin (SA), the most abundant protein in plasma, functions as the most important carrier of vital drugs, including dietary flavonoids.	Flavonoids	131-141	albumin	Homo sapiens	0-13
23815082-4	2014	The present review summarizes the interactions of flavonoids categorized as flavanol, flavonol, flavone, isoflavone, flavanones, and anthocyanidins with SAs (bovine serum albumin and human serum albumin) in light of SAR.	Flavonoids	50-60	albumin	Homo sapiens	165-178
23815082-4	2014	The present review summarizes the interactions of flavonoids categorized as flavanol, flavonol, flavone, isoflavone, flavanones, and anthocyanidins with SAs (bovine serum albumin and human serum albumin) in light of SAR.	Flavonoids	50-60	albumin	Homo sapiens	189-202
24735762-6	2014	Moreover, the effects of the investigated flavonoids were determined on the ABC transporter ATPase activities.	Flavonoids	42-52	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	76-91
24176739-0	2014	Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue beta-glucuronidase.	Flavonoids	18-27	glucuronidase beta	Homo sapiens	109-127
24269256-0	2014	Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis.	Flavonoids	8-18	annexin A1	Homo sapiens	46-56
23983093-6	2014	These findings first demonstrate that flavonoid-rich A. communis may exert potent anti-inflammatory activity through modulation of COX-2 in TPA-activated skin and tumor tissues.	Flavonoids	38-47	prostaglandin-endoperoxide synthase 2	Mus musculus	131-136
24269256-8	2014	Because these observations implicate involvement of annexin A1 in mutagenesis, we examined if flavonoids suppress nuclear annexin A1 helicase activity.	Flavonoids	94-104	annexin A1	Homo sapiens	122-132
24269256-11	2014	The apparent direct binding of anti-mutagenic flavonoids to the annexin A1 molecule was supported by fluorescence quenching.	Flavonoids	46-56	annexin A1	Homo sapiens	64-74
25150309-0	2014	Involvement of C/EBPbeta in monocytic differentiation of acute myeloid leukemia cells induced by LW-218, a new synthesized flavonoid.	Flavonoids	123-132	CCAAT enhancer binding protein beta	Homo sapiens	15-24
24956120-2	2014	Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay.	Flavonoids	6-16	ATP binding cassette subfamily C member 1	Homo sapiens	148-152
25150309-8	2014	All these results suggested that C/EBPbeta was involved in regulation of PKCdelta/PLSCR1 pathway during flavonoids-induced differentiation.	Flavonoids	104-114	CCAAT enhancer binding protein beta	Homo sapiens	33-42
25150309-8	2014	All these results suggested that C/EBPbeta was involved in regulation of PKCdelta/PLSCR1 pathway during flavonoids-induced differentiation.	Flavonoids	104-114	protein kinase C delta	Homo sapiens	73-81
25150309-8	2014	All these results suggested that C/EBPbeta was involved in regulation of PKCdelta/PLSCR1 pathway during flavonoids-induced differentiation.	Flavonoids	104-114	phospholipid scramblase 1	Homo sapiens	82-88
23494828-0	2014	Protective effects of total flavonoids from Epimedium on the male mouse reproductive system against cyclophosphamide-induced oxidative injury by up-regulating the expressions of SOD3 and GPX1.	Flavonoids	28-38	superoxide dismutase 3, extracellular	Mus musculus	178-182
24640977-4	2014	Preclinically, the first line of defense is behavior-lowering peripheral insulin resistance (e.g., physical exercise and a Mediterranean diet supplemented with foods rich in flavonoids, curcumin and omega-3 fatty acids).	Flavonoids	174-184	insulin	Homo sapiens	73-80
24251900-10	2014	The ugt78d2-dependent growth defects were flavonoid dependent, as they were rescued by genetic blocking of flavonoid biosynthesis.	Flavonoids	42-51	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	4-11
24251900-10	2014	The ugt78d2-dependent growth defects were flavonoid dependent, as they were rescued by genetic blocking of flavonoid biosynthesis.	Flavonoids	107-116	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	4-11
25256427-0	2014	Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells.	Flavonoids	0-9	AF4/FMR2 family member 1	Homo sapiens	34-37
25256427-2	2014	Here we report anticancer properties and possible mechanism of action of apple flavonoid-enriched fraction (AF4) isolated from the peels of Northern Spy apples in human hepatocellular carcinoma cells, HepG2.	Flavonoids	79-88	AF4/FMR2 family member 1	Homo sapiens	108-111
23494828-0	2014	Protective effects of total flavonoids from Epimedium on the male mouse reproductive system against cyclophosphamide-induced oxidative injury by up-regulating the expressions of SOD3 and GPX1.	Flavonoids	28-38	glutathione peroxidase 1	Mus musculus	187-191
25410365-4	2014	The amount or activity of ECM-degrading enzymes like matrix metalloproteinases can be modulated indirectly via the regulation of endogenous inhibitors like TIMPs and RECK or at the transcriptional and translational levels using, e.g., histone deacetylase inhibitors, synthetic inhibitors like Periostat, microRNA-interfering drugs like AC1MMYR2, and natural compounds like flavonoids, epigallocatechin-3-gallate, anacardic acid, and erythropoietin.	Flavonoids	373-383	erythropoietin	Homo sapiens	433-447
24102754-3	2014	In this work to overcome this limitation, the activation of multiple genes of flavonoid pathway using Arabidopsis transcription factor AtMYB12 has been carried out.	Flavonoids	78-87	myb domain protein 12	Arabidopsis thaliana	135-142
24239187-0	2013	The effect of the skeleton structure of flavanone and flavonoid on interaction with transferrin.	Flavonoids	54-63	transferrin	Homo sapiens	84-95
24024667-0	2014	Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling.	Flavonoids	12-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
24754177-0	2014	[Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH].	Flavonoids	22-32	sirtuin 1	Mus musculus	56-61
24754177-0	2014	[Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH].	Flavonoids	22-32	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	62-72
24376816-0	2013	Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function.	Flavonoids	55-65	protein E6*;transforming protein E6	Human papillomavirus type 16	103-105
24239187-2	2013	In the present study, we identified specific structural features in flavonoids that were critical for binding to transferrin.	Flavonoids	68-78	transferrin	Homo sapiens	113-124
24140887-9	2013	This finding will strengthen the anti-cancer effects of flavonoid compounds via the regulation of migration/invasion and EMT ability of various cancer cells.	Flavonoids	56-65	IL2 inducible T cell kinase	Homo sapiens	121-124
24219111-5	2013	Docking studies indicated that phenolic acids and flavonoids inhibit ACE via interaction with the zinc ion and this interaction is stabilized by other interactions with amino acids in the active site.	Flavonoids	50-60	angiotensin I converting enzyme	Homo sapiens	69-72
24261475-1	2013	Several plant extracts rich in flavonoids have been reported to improve hyperglycemia by inhibiting digestive enzyme activities and SGLT1-mediated glucose uptake.	Flavonoids	31-41	solute carrier family 5 member 1	Rattus norvegicus	132-137
24060295-7	2013	CHS8 is a key enzyme in plant flavonoid biosynthesis.	Flavonoids	30-39	chalcone synthase	Glycine max	0-4
24352055-0	2013	Characterization of flavonoids in the ethomedicine Fordiae Cauliflorae Radix and its adulterant Millettiae Pulchrae Radix by HPLC-DAD-ESI-IT-TOF-MSn.	Flavonoids	20-30	moesin	Homo sapiens	145-148
24352055-5	2013	To further utilize these two ethnodrugs and identify them unambiguously, an HPLC-DAD-ESI-IT-TOF-MSn method was developed to separate and characterize the flavonoids in FC and MP.	Flavonoids	154-164	moesin	Homo sapiens	96-99
23172577-1	2013	The aim of this study was to assess the effect of the flavonoid naringin on the growth of the spheno-occipital synchondrosis by quantifying the levels of expression of Sox9 and PTHrP in an in vitro mouse model.	Flavonoids	54-63	parathyroid hormone-like peptide	Mus musculus	177-182
24329115-0	2013	Biotransformations of prenylated hop flavonoids for drug discovery and production.	Flavonoids	37-47	HOP homeobox	Homo sapiens	33-36
24329115-1	2013	In this review we aim to present current knowledge on biotransformation of flavonoids from hop cones with respect to type of product, catalyst and conversion.	Flavonoids	75-85	HOP homeobox	Homo sapiens	91-94
24329115-2	2013	Subsequently, a comparative analysis of biological activity of prenylated hop flavonoids and their biotransformation products has been performed in order to indicate these research efforts that have good potential for application in pharmaceutical industry.	Flavonoids	78-88	HOP homeobox	Homo sapiens	74-77
24145114-0	2013	The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling.	Flavonoids	14-23	mitogen-activated protein kinase 14	Mus musculus	102-108
24106139-6	2013	The results of this study showed some promising advantages of MLC for the simultaneous separation of phenolic acids and flavonoids, including low consumption of organic solvent, good resolution, short analysis time, and no requirement of gradient elution.	Flavonoids	120-130	modulator of VRAC current 1	Homo sapiens	62-65
24378636-10	2013	Furthermore, following treatment of NaCl, UV-B, and drought stress, the expression levels of IbMYB1 and several structural genes in the flavonoid biosynthesis such as CHS, DFR, and ANS in transgenic plants were found to be correlated with plant phenotype.	Flavonoids	136-145	dihydroflavonol-4-reductase	Solanum tuberosum	172-175
23441850-3	2013	In the current study, we investigated the effect of the flavonoid isorhamnetin on the production of IL-6 in murine macrophages stimulated with lipopolysaccharide (LPS) from Prevotella intermedia, a pathogen implicated in inflammatory periodontal disease, and its mechanisms of action.	Flavonoids	56-65	interleukin 6	Mus musculus	100-104
24118612-11	2013	Genetic experiments revealed that the chalcone synthase mutant tt4-11 lacking flavonoid biosynthesis abrogated the auxin-related defects caused by mTCP3.	Flavonoids	78-87	t-complex protein 3	Mus musculus	147-152
24118612-0	2013	TCP3 interacts with R2R3-MYB proteins, promotes flavonoid biosynthesis and negatively regulates the auxin response in Arabidopsis thaliana.	Flavonoids	48-57	TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3	Arabidopsis thaliana	0-4
23943362-0	2013	Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3beta/NF-kappaB signaling cascade.	Flavonoids	0-9	glycogen synthase kinase 3 beta	Homo sapiens	161-170
24022064-8	2013	Genes for chalcone synthase (CHS), a key enzyme of the flavonoid pathway, are posttranscriptionally silenced by the inhibitor (I) locus in nonpigmented (yellow) soybean seeds.	Flavonoids	55-64	chalcone synthase	Glycine max	10-27
24022064-8	2013	Genes for chalcone synthase (CHS), a key enzyme of the flavonoid pathway, are posttranscriptionally silenced by the inhibitor (I) locus in nonpigmented (yellow) soybean seeds.	Flavonoids	55-64	chalcone synthase	Glycine max	29-32
24243544-0	2013	Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron.	Flavonoids	0-10	discs large MAGUK scaffold protein 4	Rattus norvegicus	74-105
24118612-8	2013	Transcriptome analysis of mTCP3 and TCP3SRDX plants supported a role for TCP3 in enhancing flavonoid biosynthesis.	Flavonoids	91-100	t-complex protein 3	Mus musculus	26-31
24118612-12	2013	Together, these data suggest that TCP3 interactions with R2R3-MYBs lead to enhanced flavonoid production, which further negatively modulates the auxin response.	Flavonoids	84-93	chaperonin-containing T-complex subunit CCT3	Saccharomyces cerevisiae S288C	34-38
24243544-3	2013	Here, different subclasses of flavonoids were analyzed for their inductive roles in promoting the expression of synaptic proteins, synaptotagmin, and post-synaptic density protein-95 in cultured rat cortical neurons.	Flavonoids	30-40	discs large MAGUK scaffold protein 4	Rattus norvegicus	150-182
24121417-3	2013	To understand this problem, we investigated the participation of flavanone 3-hydroxylase gene (F3H), a key enzyme in flavonoid biosynthetic pathway under UV-B radiation and drought stress in the desert plant Reaumuria soongorica.	Flavonoids	117-126	naringenin,2-oxoglutarate 3-dioxygenase	Malus domestica	95-98
24116089-0	2013	Probing the interaction of a therapeutic flavonoid, pinostrobin with human serum albumin: multiple spectroscopic and molecular modeling investigations.	Flavonoids	41-50	albumin	Homo sapiens	75-88
24085296-0	2013	Flavonoid regulation of HCN2 channels.	Flavonoids	0-9	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	24-28
24045947-6	2013	Thus, UGT708A6 is a bifunctional glycosyltransferase that can produce both C- and O-glycosidated flavonoids, a property not previously described for any other glycosyltransferase.	Flavonoids	97-107	UDP-glycosyltransferase 708A6	Zea mays	6-14
23861337-0	2013	Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway.	Flavonoids	27-36	thymoma viral proto-oncogene 1	Mus musculus	144-147
24558856-1	2013	Licochalcone A (LCA), as a major flavonoid in Glycyrrhiza inflate, has attracted wide attention in recent years.	Flavonoids	33-42	clathrin light chain A	Homo sapiens	16-19
24146961-3	2013	We found that pretreatment with digitoflavone, a plant flavonoid, greatly sensitized TNFalpha-induced apoptotic cell death in several human pancreatic cancer cells.	Flavonoids	55-64	tumor necrosis factor	Homo sapiens	85-93
24148417-0	2013	A structure-differential binding method for elucidating the interactions between flavonoids and cytochrome-c by ESI-MS and molecular docking.	Flavonoids	81-91	cytochrome c, somatic	Homo sapiens	96-108
24148417-4	2013	Using this developed method, protein complexes of flavonoid and flavonoid glycoside ligands and cytochrome-c (Cyt-c) were studied in detail.	Flavonoids	50-59	cytochrome c, somatic	Homo sapiens	96-108
24148417-4	2013	Using this developed method, protein complexes of flavonoid and flavonoid glycoside ligands and cytochrome-c (Cyt-c) were studied in detail.	Flavonoids	50-59	cytochrome c, somatic	Homo sapiens	110-115
24148417-5	2013	ESI-MS was used to determine the relative binding affinities and dissociation constants of flavonoid-Cyt-c complexes, and to measure the changes in the stability of the protein complexes with the structural modifications of the ligands for identifying effective binding functional groups.	Flavonoids	91-100	cytochrome c, somatic	Homo sapiens	101-106
24117141-0	2013	Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.	Flavonoids	36-46	taste 2 receptor member 14	Homo sapiens	116-124
24117141-0	2013	Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.	Flavonoids	36-46	taste 2 receptor member 39	Homo sapiens	129-137
24117141-2	2013	The aim of this study was to investigate the effect of a large set of structurally similar (iso)flavonoids on the activation of bitter receptors hTAS2R14 and hTAS2R39 and to predict their structural requirements to activate these receptors.	Flavonoids	96-106	taste 2 receptor member 14	Homo sapiens	145-153
24117141-2	2013	The aim of this study was to investigate the effect of a large set of structurally similar (iso)flavonoids on the activation of bitter receptors hTAS2R14 and hTAS2R39 and to predict their structural requirements to activate these receptors.	Flavonoids	96-106	taste 2 receptor member 39	Homo sapiens	158-166
24029069-5	2013	Flavonoids may exert beneficial effects in diabetes by (i) enhancing insulin secretion and reducing apoptosis and promoting proliferation of pancreatic beta-cells; (ii) improving hyperglycemia through regulation of glucose metabolism in hepatocytes; (iii) reducing insulin resistance, inflammation and oxidative stress in muscle and fat and (iv) increasing glucose uptake in skeletal muscle and white adipose tissue.	Flavonoids	0-10	insulin	Homo sapiens	69-76
23894034-0	2013	In vivo validation and physiologically based biokinetic modeling of the inhibition of SULT-mediated estragole DNA adduct formation in the liver of male Sprague-Dawley rats by the basil flavonoid nevadensin.	Flavonoids	185-194	carbohydrate sulfotransferase 10	Rattus norvegicus	86-90
24076393-0	2013	The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase.	Flavonoids	4-13	aralkylamine N-acetyltransferase	Rattus norvegicus	98-127
24116089-1	2013	Interaction of a pharmacologically important flavonoid, pinostrobin (PS) with the major transport protein of human blood circulation, human serum albumin (HSA) has been examined using a multitude of spectroscopic techniques and molecular docking studies.	Flavonoids	45-54	albumin	Homo sapiens	140-153
23920220-11	2013	The data seemingly consistent with the Remote Sensing and Signaling Hypothesis (Ahn and Nigam, 2009; Wu et al., 2011), also suggests that Oat3 is essential for the handling of dietary flavonoids and antioxidants.	Flavonoids	184-194	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	138-142
23801300-2	2013	The glycosylation of flavonoids is mediated by uridine diphosphate-dependent glycosyltransferases (UGT).	Flavonoids	21-31	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	47-97
23921543-0	2013	Proteolytic degradation of the flavonoid regulators, TRANSPARENT TESTA8 and TRANSPARENT TESTA GLABRA1, in Arabidopsis is mediated by the ubiquitin/26Sproteasome system.	Flavonoids	31-40	myb domain protein 0	Arabidopsis thaliana	94-101
23921543-3	2013	The bHLH TF, TRAN SPAR ENT TESTA 8 (TT 8), and the WDR protein, TRAN SPAR ENT TESTA GLABRA 1 (TT G1), are essential for expression of late flavonoid biosynthesis genes.	Flavonoids	139-148	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	36-40
23871783-5	2013	Pretreatment of cells with 11-19 muM of either flavonoid for 24h resulted in 59-73% growth inhibition when followed by Gem (10 muM, 36 h).	Flavonoids	47-56	latexin	Homo sapiens	33-36
23871783-5	2013	Pretreatment of cells with 11-19 muM of either flavonoid for 24h resulted in 59-73% growth inhibition when followed by Gem (10 muM, 36 h).	Flavonoids	47-56	latexin	Homo sapiens	127-130
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	tyrosinase	Mus musculus	131-141
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	tyrosinase	Mus musculus	179-189
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	cAMP responsive element binding protein 1	Mus musculus	228-265
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	cAMP responsive element binding protein 1	Mus musculus	267-271
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	mitogen-activated protein kinase 3	Mus musculus	331-337
23208771-7	2013	These results indicate that the 4"-O-methyl group of flavonoids plays an important role in the induction of melanogenesis by activating its major signal transduction pathway through the upregulation of phospho-CREB in murine B16F10 melanoma cells.	Flavonoids	53-63	cAMP responsive element binding protein 1	Mus musculus	210-214
24133614-2	2013	After further purification by macroporous AB-8 resin, the color value of PSP anthocyanin (PSPA) reached 30.15 with a total flavonoid concentration of 932.5 mg/g.	Flavonoids	123-132	surfactant associated protein A1	Mus musculus	73-88
23801300-2	2013	The glycosylation of flavonoids is mediated by uridine diphosphate-dependent glycosyltransferases (UGT).	Flavonoids	21-31	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	99-102
24250287-2	2013	OBJECTIVE: To evaluate the inhibition potential of wogonin (an important flavonoid isolated from the root of Scutellaria baicalensis) towards one of the most important phase II DMEs, UDP-glucuronosyltransferase (UGT) 1A9.	Flavonoids	73-82	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	183-220
23541171-6	2013	A recent high-throughput screening identified the commonly ingested flavonoid, quercetin-3-rutinoside, as an inhibitor of PDI.	Flavonoids	68-77	prolyl 4-hydroxylase subunit beta	Homo sapiens	122-125
23947936-4	2013	The ability of flavonoids to inhibit LPS-induced IkappaB-alpha degradation and COX-2 expression was used as a model for the inflammatory response.	Flavonoids	15-25	toll-like receptor 4	Mus musculus	37-40
23947936-4	2013	The ability of flavonoids to inhibit LPS-induced IkappaB-alpha degradation and COX-2 expression was used as a model for the inflammatory response.	Flavonoids	15-25	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	49-62
23947936-7	2013	All flavonoids tested were able to inhibit IkappaB-alpha degradation, but only diplacone (4) also down-regulated COX-2 expression.	Flavonoids	4-14	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	43-56
24044691-2	2013	The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, luteolin, galangin, and genistein) against the dermatophyte Trichophyton rubrum and their effects on fatty acid and ergosterol synthesis.	Flavonoids	65-75	fatty acid synthase	Homo sapiens	118-121
24044691-6	2013	Inhibition of FAS by flavonoids was evaluated by an enzymatic assay to determine IC50 values.	Flavonoids	21-31	fatty acid synthase	Homo sapiens	14-17
24018886-0	2013	Flavonoids from Orostachys japonicus A. Berger inhibit the invasion of LnCaP prostate carcinoma cells by inactivating Akt and modulating tight junctions.	Flavonoids	0-10	AKT serine/threonine kinase 1	Homo sapiens	118-121
24023911-5	2013	Flavonoids are polyhydroxyphenolic compounds, found in vegetables present in human diet, and have been shown not only to modulate NIS, but also thyroperoxidase (TPO), the key enzyme in thyroid hormones biosynthesis, besides having antiproliferative effect in thyroid cancer cell lines.	Flavonoids	0-10	thyroid peroxidase	Homo sapiens	144-159
24023911-5	2013	Flavonoids are polyhydroxyphenolic compounds, found in vegetables present in human diet, and have been shown not only to modulate NIS, but also thyroperoxidase (TPO), the key enzyme in thyroid hormones biosynthesis, besides having antiproliferative effect in thyroid cancer cell lines.	Flavonoids	0-10	thyroid peroxidase	Homo sapiens	161-164
22137869-5	2013	The results showed that this flavonoid was able to increase ADP hydrolysis and inhibit the ecto-5"-nucleotidase/CD73 activity, with no effect on protein expression.	Flavonoids	29-38	5'-nucleotidase ecto	Homo sapiens	91-111
22137869-5	2013	The results showed that this flavonoid was able to increase ADP hydrolysis and inhibit the ecto-5"-nucleotidase/CD73 activity, with no effect on protein expression.	Flavonoids	29-38	5'-nucleotidase ecto	Homo sapiens	112-116
23845967-2	2013	The flavonoid was given orally to mice for 7days and then on the 8th day, these were intraperitoneally injected with 10mmol/kg CCl4.	Flavonoids	4-13	chemokine (C-C motif) ligand 4	Mus musculus	127-131
23902763-3	2013	In this study, we investigated the use of Notch-1-regulating flavonoid compounds as novel therapeutic drugs to regulate radiosensitivity in NSCLC cells, NCI-H1299 and NCI-H460, with different levels of radioresistance.	Flavonoids	61-70	notch 1	Mus musculus	42-49
23812412-0	2013	Fir honeydew honey flavonoids inhibit TNF-alpha-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing.	Flavonoids	19-29	tumor necrosis factor	Homo sapiens	38-47
23272907-8	2013	The ability of quercetin to inhibit mTOR activity by multiple pathways makes this otherwise safe bioflavonoid an interesting tool for the treatment of cancers and other diseases associated with mTOR deregulation.	Flavonoids	97-109	mechanistic target of rapamycin kinase	Homo sapiens	36-40
23272907-8	2013	The ability of quercetin to inhibit mTOR activity by multiple pathways makes this otherwise safe bioflavonoid an interesting tool for the treatment of cancers and other diseases associated with mTOR deregulation.	Flavonoids	97-109	mechanistic target of rapamycin kinase	Homo sapiens	194-198
23812412-0	2013	Fir honeydew honey flavonoids inhibit TNF-alpha-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing.	Flavonoids	19-29	matrix metallopeptidase 9	Homo sapiens	56-61
23812412-8	2013	Apigenin and kaempferol, identified flavonoids in HAE, markedly inhibited MMP-9 production from HaCaT and epidermal keratinocytes.	Flavonoids	36-46	matrix metallopeptidase 9	Homo sapiens	74-79
23812412-9	2013	Taken together, fir honeydew honey, which contains certain flavonoids, prevents TNF-alpha-induced proteolytic activity in cutaneous inflammation.	Flavonoids	59-69	tumor necrosis factor	Homo sapiens	80-89
24004829-2	2013	HCTR enzyme shares 29.6% sequence identity with dihydroflavonol reductase (DFR) of grape, a key enzyme involved in flavonoid biosynthesis.	Flavonoids	115-124	dihydroflavonol 4-reductase	Zea mays	48-73
23824743-0	2013	Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and beta-catenin.	Flavonoids	34-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	103-106
23824743-0	2013	Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and beta-catenin.	Flavonoids	34-43	catenin beta 1	Homo sapiens	111-123
23827777-12	2013	Also, glutathione and superoxide dismutase (SOD)-levels were restored towards normalcy in the liver of CCl4-treated rats, indicating the hepatoprotective role of NPW, which was found to contain a fair amount of flavonoids, phenolics, and saponin constituents.	Flavonoids	211-221	C-C motif chemokine ligand 4	Rattus norvegicus	103-107
24004829-2	2013	HCTR enzyme shares 29.6% sequence identity with dihydroflavonol reductase (DFR) of grape, a key enzyme involved in flavonoid biosynthesis.	Flavonoids	115-124	dihydroflavonol 4-reductase	Zea mays	75-78
23811214-5	2013	MATERIALS AND METHODS: Nelumbo nucifera leaf flavonoids (NLF) were tested for the inhibition of lipase, alpha-glucosidase, and alpha-amylase activities in vitro.	Flavonoids	45-55	alpha-glucosidase	Nelumbo nucifera	104-121
23677714-9	2013	Taken together, the study demonstrated that flavonoids of luteolin prevent the migration of glioblastoma cells by affecting PI3K/AKT activation, modulating the protein expression of Cdc42 and facilitating their degradation via the proteaosome pathway.	Flavonoids	44-54	AKT serine/threonine kinase 1	Homo sapiens	129-132
23677714-9	2013	Taken together, the study demonstrated that flavonoids of luteolin prevent the migration of glioblastoma cells by affecting PI3K/AKT activation, modulating the protein expression of Cdc42 and facilitating their degradation via the proteaosome pathway.	Flavonoids	44-54	cell division cycle 42	Homo sapiens	182-187
23165939-3	2013	The aim of this investigation was to determine whether Glycyrrhiza uralensis flavonoids have inhibitory effects on memory Th2 responses in vitro and antigen-induced Th2 inflammation in vivo.	Flavonoids	77-87	heart and neural crest derivatives expressed 2	Mus musculus	122-125
24009741-0	2013	The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9.	Flavonoids	4-13	ribosomal protein S9	Homo sapiens	64-84
24009741-3	2013	In the present study, we developed a novel method using magnetic FG beads to purify flavonoid-binding proteins, and identified ribosomal protein S9 (RPS9) as a binding partner of the flavonoid apigenin.	Flavonoids	84-93	ribosomal protein S9	Homo sapiens	127-147
24009741-3	2013	In the present study, we developed a novel method using magnetic FG beads to purify flavonoid-binding proteins, and identified ribosomal protein S9 (RPS9) as a binding partner of the flavonoid apigenin.	Flavonoids	84-93	ribosomal protein S9	Homo sapiens	149-153
24009741-3	2013	In the present study, we developed a novel method using magnetic FG beads to purify flavonoid-binding proteins, and identified ribosomal protein S9 (RPS9) as a binding partner of the flavonoid apigenin.	Flavonoids	183-192	ribosomal protein S9	Homo sapiens	127-147
24009741-3	2013	In the present study, we developed a novel method using magnetic FG beads to purify flavonoid-binding proteins, and identified ribosomal protein S9 (RPS9) as a binding partner of the flavonoid apigenin.	Flavonoids	183-192	ribosomal protein S9	Homo sapiens	149-153
23794501-3	2013	Eight major flavonoids (naringin, naringenin, hesperidin, hesperetin, phloridzin, phloretin, quercetin, and kaempferol) contained in the juices inhibited OATP2B1-mediated estrone-3-sulfate uptake with IC50 values of 4.63, 49.2, 1.92, 67.6, 23.2, 1.31, 9.47, and 21.3 muM, respectively.	Flavonoids	12-22	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	154-161
23500004-4	2013	7,8-Dihydroxyflavone (7,8-DHF), a member of the flavonoid family, has been described as a robust TrkB receptor agonist in hippocampal neurons.	Flavonoids	48-57	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	97-101
23912028-11	2013	The metabolite profiling revealed that not only lipid but also sugar, flavonoid and glycoalkaloid metabolites in fruit were changed in the cd2 mutant.	Flavonoids	70-79	cutin deficient 2	Solanum lycopersicum	139-142
24009741-0	2013	The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9.	Flavonoids	4-13	cyclin dependent kinase 1	Homo sapiens	37-41
23844653-5	2013	In this study, ABCA1 up-regulators were identified from a series of flavonoids and were found to preferentially activate LXRbeta and up-regulate expression of ABCA1 and apoE in different cell lines.	Flavonoids	68-78	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	15-20
23844653-5	2013	In this study, ABCA1 up-regulators were identified from a series of flavonoids and were found to preferentially activate LXRbeta and up-regulate expression of ABCA1 and apoE in different cell lines.	Flavonoids	68-78	nuclear receptor subfamily 1, group H, member 2	Mus musculus	121-128
23844653-0	2013	Synthesis and identification of new flavonoids targeting liver X receptor beta involved pathway as potential facilitators of Abeta clearance with reduced lipid accumulation.	Flavonoids	36-46	nuclear receptor subfamily 1, group H, member 2	Mus musculus	57-78
23844653-0	2013	Synthesis and identification of new flavonoids targeting liver X receptor beta involved pathway as potential facilitators of Abeta clearance with reduced lipid accumulation.	Flavonoids	36-46	amyloid beta (A4) precursor protein	Mus musculus	125-130
23844653-5	2013	In this study, ABCA1 up-regulators were identified from a series of flavonoids and were found to preferentially activate LXRbeta and up-regulate expression of ABCA1 and apoE in different cell lines.	Flavonoids	68-78	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	159-164
23844653-5	2013	In this study, ABCA1 up-regulators were identified from a series of flavonoids and were found to preferentially activate LXRbeta and up-regulate expression of ABCA1 and apoE in different cell lines.	Flavonoids	68-78	apolipoprotein E	Mus musculus	169-173
23976825-5	2013	RESULTS: Docking of NS3/4A protease and Flavonoids of Accacia nilotica revealed that most of the flavonoids bound deeply with the active site of NS3/4A protease.	Flavonoids	40-50	KRAS proto-oncogene, GTPase	Homo sapiens	145-148
23976825-5	2013	RESULTS: Docking of NS3/4A protease and Flavonoids of Accacia nilotica revealed that most of the flavonoids bound deeply with the active site of NS3/4A protease.	Flavonoids	97-107	KRAS proto-oncogene, GTPase	Homo sapiens	20-23
22524676-0	2013	The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.	Flavonoids	98-107	matrix metallopeptidase 1	Homo sapiens	34-56
23976825-5	2013	RESULTS: Docking of NS3/4A protease and Flavonoids of Accacia nilotica revealed that most of the flavonoids bound deeply with the active site of NS3/4A protease.	Flavonoids	97-107	KRAS proto-oncogene, GTPase	Homo sapiens	145-148
23786524-0	2013	Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids.	Flavonoids	82-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-48
23786524-1	2013	UDP-glucuronosyltransferase (UGT) 1A1-catalyzed glucuronidation is an important elimination pathway of flavonoids, and mutually inhibitory interactions may occur when two or more flavonoids are coadministered.	Flavonoids	103-113	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
23786524-1	2013	UDP-glucuronosyltransferase (UGT) 1A1-catalyzed glucuronidation is an important elimination pathway of flavonoids, and mutually inhibitory interactions may occur when two or more flavonoids are coadministered.	Flavonoids	179-189	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
23786524-2	2013	Our recent research suggested that glucuronidation of flavonoids displayed distinct positional preferences, but whether this will lead to the mutually regioselective inhibition of UGT1A1-mediated glucuronidation of flavonoids is unknown.	Flavonoids	54-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	180-186
23786524-2	2013	Our recent research suggested that glucuronidation of flavonoids displayed distinct positional preferences, but whether this will lead to the mutually regioselective inhibition of UGT1A1-mediated glucuronidation of flavonoids is unknown.	Flavonoids	215-225	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	180-186
23796453-2	2013	While Pin1 poses challenges for drug discovery, several groups have identified potent antagonists by structure based drug design, significant progress has been made designing peptidic inhibitors and a number of natural products have been found that blockade Pin1, notably epigallocatchechin gallate (EGCG), a major flavonoid in green tea.	Flavonoids	315-324	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	258-262
23508039-4	2013	PON1 is highly sensitive to variations in its milieu, and endogenous compounds (fatty acids, phospholipids), nutritional ingredients (flavonoids and other antioxidants), and environmental elements (reactive nitrogen and oxygen species, metals, surfactants), significantly affect the enzyme"s activities.	Flavonoids	134-144	paraoxonase 1	Homo sapiens	0-4
22524676-4	2013	Effects of 17 structure-related flavonoids on MMP-1 activity are evaluated using a fluorescent assay, 6 inhibitors are identified with IC50 &lt; 10 microM.	Flavonoids	32-42	matrix metallopeptidase 1	Homo sapiens	46-51
23575887-10	2013	Because UGT2B17 metabolizes certain nonsteroidal anti-inflammatory drugs and flavonoids with antioxidative properties, individuals with a gene deletion may have higher levels of these protective dietary components.	Flavonoids	77-87	UDP glucuronosyltransferase family 2 member B17	Homo sapiens	8-15
23639191-0	2013	Involvement of p-CREB and phase II detoxifying enzyme system in neuroprotection mediated by the flavonoid calycopterin isolated from Dracocephalum kotschyi.	Flavonoids	96-105	cAMP responsive element binding protein 1	Rattus norvegicus	17-21
23904741-4	2013	Based on our earlier findings with Hippophae rhamnoides, a group of flavonoids and tannins were screened for their docking potential with Fn14 at the site where its natural ligand TWEAK was binding.	Flavonoids	68-78	TNF superfamily member 12	Homo sapiens	180-185
23643881-1	2013	We have recently synthesized a series of phosphorylated flavonoids and identified some of them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity for CEase over acetylcholinesterase (AChE).	Flavonoids	56-66	carboxyl ester lipase	Homo sapiens	152-157
23643881-1	2013	We have recently synthesized a series of phosphorylated flavonoids and identified some of them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity for CEase over acetylcholinesterase (AChE).	Flavonoids	56-66	carboxyl ester lipase	Homo sapiens	190-195
23643881-1	2013	We have recently synthesized a series of phosphorylated flavonoids and identified some of them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity for CEase over acetylcholinesterase (AChE).	Flavonoids	56-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	223-227
23733058-2	2013	One major class of polyphenols are the flavonoids and their formation is dependent on the enzyme chalcone synthase (CHS).	Flavonoids	39-49	polyketide synthase 5	Malus domestica	116-119
23760261-0	2013	Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1beta production following Toll-like receptor 2 stimulation in THP-1 monocytes.	Flavonoids	39-48	interleukin 1 beta	Homo sapiens	79-87
23760261-0	2013	Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1beta production following Toll-like receptor 2 stimulation in THP-1 monocytes.	Flavonoids	39-48	toll like receptor 2	Homo sapiens	109-129
23760261-0	2013	Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1beta production following Toll-like receptor 2 stimulation in THP-1 monocytes.	Flavonoids	39-48	GLI family zinc finger 2	Homo sapiens	145-150
23760261-2	2013	In this context, we have examined five classes of plant-derived flavonoids (flavonols, flavones, flavanones, catechins, and cyanidin) for their ability to regulate cytokine release induced by the Toll-like receptor 2 (TLR2) agonist Pam3CSK4.	Flavonoids	64-74	toll like receptor 2	Homo sapiens	196-216
23760261-2	2013	In this context, we have examined five classes of plant-derived flavonoids (flavonols, flavones, flavanones, catechins, and cyanidin) for their ability to regulate cytokine release induced by the Toll-like receptor 2 (TLR2) agonist Pam3CSK4.	Flavonoids	64-74	toll like receptor 2	Homo sapiens	218-222
23583258-6	2013	Oxysterol-dependent NOX1 activation, as well as interleukin synthesis, were completely prevented by Cannonau red wine extract that contains an abundant phenolic fraction, in particular phenolic acids and flavonoids.	Flavonoids	204-214	NADPH oxidase 1	Homo sapiens	20-24
23752494-6	2013	Flavonoids are powerful antioxidants and anti-allergic nutrients that inhibit the release of chemical mediators, synthesis of Th2 type cytokines, such as interleukin (IL)-4 and IL-13, and CD40 ligand expression by high-affinity immunoglobulin E (IgE) receptor-expressing cells, such as mast cells and basophils.	Flavonoids	0-10	CD40 molecule	Homo sapiens	188-192
23300027-2	2013	Flavopiridol is a flavonoid derived from an indigenous plant act as a potent antitumor drug showing increased inhibitory activity toward CDK2.	Flavonoids	18-27	cyclin dependent kinase 2	Homo sapiens	137-141
23560676-0	2013	On the repair of oxidative damage to apoferritin: a model study with the flavonoids quercetin and rutin in aerated and deaerated solutions.	Flavonoids	73-83	ferritin heavy chain	Equus caballus	37-48
23908081-0	2013	[Chuju total flavonoids control the SFRP4 expression in Wnt pathway in rheumatoid arthritis model rats].	Flavonoids	13-23	secreted frizzled-related protein 4	Rattus norvegicus	36-41
23908081-0	2013	[Chuju total flavonoids control the SFRP4 expression in Wnt pathway in rheumatoid arthritis model rats].	Flavonoids	13-23	Wnt family member 2	Rattus norvegicus	56-59
23908081-1	2013	OBJECTIVE: To determine the effect of Chuju total flavonoids (CJTF) on the secreted frizzledrelated protein 4 (SFRP4) expression in Wnt pathway in rheumatoid arthritis (RA) model rats.	Flavonoids	50-60	secreted frizzled-related protein 4	Rattus norvegicus	75-109
23908081-1	2013	OBJECTIVE: To determine the effect of Chuju total flavonoids (CJTF) on the secreted frizzledrelated protein 4 (SFRP4) expression in Wnt pathway in rheumatoid arthritis (RA) model rats.	Flavonoids	50-60	secreted frizzled-related protein 4	Rattus norvegicus	111-116
23908081-1	2013	OBJECTIVE: To determine the effect of Chuju total flavonoids (CJTF) on the secreted frizzledrelated protein 4 (SFRP4) expression in Wnt pathway in rheumatoid arthritis (RA) model rats.	Flavonoids	50-60	Wnt family member 2	Rattus norvegicus	132-135
23570998-7	2013	Further, both the flavonoids were also found to increase the expression of some of the prominent markers for differentiation of osteoblast like osteopontin, osterix, RunX2, osteoprotegerin and osteocalcin.	Flavonoids	18-28	secreted phosphoprotein 1	Mus musculus	144-155
23570998-7	2013	Further, both the flavonoids were also found to increase the expression of some of the prominent markers for differentiation of osteoblast like osteopontin, osterix, RunX2, osteoprotegerin and osteocalcin.	Flavonoids	18-28	Sp7 transcription factor 7	Mus musculus	157-164
23570998-7	2013	Further, both the flavonoids were also found to increase the expression of some of the prominent markers for differentiation of osteoblast like osteopontin, osterix, RunX2, osteoprotegerin and osteocalcin.	Flavonoids	18-28	runt related transcription factor 2	Mus musculus	166-171
23570998-7	2013	Further, both the flavonoids were also found to increase the expression of some of the prominent markers for differentiation of osteoblast like osteopontin, osterix, RunX2, osteoprotegerin and osteocalcin.	Flavonoids	18-28	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	173-188
23570998-7	2013	Further, both the flavonoids were also found to increase the expression of some of the prominent markers for differentiation of osteoblast like osteopontin, osterix, RunX2, osteoprotegerin and osteocalcin.	Flavonoids	18-28	bone gamma-carboxyglutamate protein 2	Mus musculus	193-204
23567286-0	2013	Catalase is inhibited by flavonoids.	Flavonoids	25-35	catalase	Bos taurus	0-8
23567286-2	2013	In this work we have shown that catalase from bovine liver is inhibited by flavonoids.	Flavonoids	75-85	catalase	Bos taurus	32-40
23567286-3	2013	The inhibition is, at least partially, due to the formation of hydrogen bonds between catalase and flavonoids.	Flavonoids	99-109	catalase	Bos taurus	86-94
23567286-4	2013	In the presence of some flavonoids the formation of unreactive catalase compound II has been detected.	Flavonoids	24-34	catalase	Bos taurus	63-71
23567286-5	2013	The most potent catalase inhibitors among the tested flavonoids have appeared myricetin, epicatechin gallate and epigallocatechin gallate.	Flavonoids	53-63	catalase	Bos taurus	16-24
23333096-0	2013	Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes.	Flavonoids	7-16	toll-like receptor 2	Mus musculus	37-41
23333096-3	2013	In this report, we show that naringenin, a citrus flavonoid, inhibits TLR2 expression during adipocyte differentiation.	Flavonoids	50-59	toll-like receptor 2	Mus musculus	70-74
23768434-0	2013	Development of flavonoid-based inverse agonists of the key signaling receptor US28 of human cytomegalovirus.	Flavonoids	15-24	envelope protein US28	Human betaherpesvirus 5	78-82
23768434-1	2013	A series of 31 chalcone- and flavonoid-based derivatives were synthesized in good overall yields and screened for their inverse agonist activity on the US28 receptor of human cytomegalovirus (HCMV).	Flavonoids	29-38	envelope protein US28	Human betaherpesvirus 5	152-156
23624232-0	2013	The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway.	Flavonoids	14-23	mitogen-activated protein kinase 14	Homo sapiens	106-112
23647459-0	2013	Avicularin, a plant flavonoid, suppresses lipid accumulation through repression of C/EBPalpha-activated GLUT4-mediated glucose uptake in 3T3-L1 cells.	Flavonoids	20-29	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	83-93
23736695-3	2013	We have investigated the impact of this flavonoid on the transcription factors DAF-16 (C. elegans FoxO homologue) and SKN-1 (Nrf2 homologue), which have crucial functions in the regulation of ageing.	Flavonoids	40-49	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	79-85
23736695-3	2013	We have investigated the impact of this flavonoid on the transcription factors DAF-16 (C. elegans FoxO homologue) and SKN-1 (Nrf2 homologue), which have crucial functions in the regulation of ageing.	Flavonoids	40-49	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	118-123
23536316-11	2013	The data also suggest that chrysin or chrysin-like flavonoids could be further developed as intestine-specific PXR activators.	Flavonoids	51-61	nuclear receptor subfamily 1, group I, member 2	Mus musculus	111-114
23825484-6	2013	Treatment of Tg2576 mice with SH-CKJ, which contains high concentrations of total flavonoids and phenolic compounds, for 8 weeks dramatically recovered the NGF level to that of Non-Tg mice.	Flavonoids	82-92	nerve growth factor	Mus musculus	156-159
23456781-0	2013	Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells.	Flavonoids	6-16	AKT serine/threonine kinase 1	Homo sapiens	80-83
23456781-0	2013	Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells.	Flavonoids	6-16	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	88-92
23567315-2	2013	In the present study, we assessed the inhibitory effects of eight dietary flavonoids representing five distinct chemical classes on cytochrome b5 reduction by purified cytochrome b5 reductase.	Flavonoids	74-84	cytochrome b5 type A	Homo sapiens	132-145
23567315-2	2013	In the present study, we assessed the inhibitory effects of eight dietary flavonoids representing five distinct chemical classes on cytochrome b5 reduction by purified cytochrome b5 reductase.	Flavonoids	74-84	cytochrome b5 type A	Homo sapiens	168-181
23567315-3	2013	From the flavonoids tested, myricetin was the most potent in inhibiting cytochrome b5 reduction with an IC50 value of 0.35muM.	Flavonoids	9-19	cytochrome b5 type A	Homo sapiens	72-85
23650897-3	2013	Investigation of two representative types of AP by preparative chromatographic procedure and mass spectrometric (MS) and NMR techniques led to the identification of their main constituents: caffeate esters and flavonoids from an AP type rich in phenolic compounds (PAP) and labdane and clerodane diterpenes, together with a polymethoxyflavonol, from an AP type containing mainly diterpenes (DAP).	Flavonoids	210-220	death associated protein	Homo sapiens	391-394
23611783-4	2013	We report here that uncharacterized AtSULT202E1 (AGI code: At2g03770), a SULT202E subfamily member, shows the sulfating activity toward flavonoids.	Flavonoids	136-146	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	36-47
23723987-0	2013	Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.	Flavonoids	23-33	brain derived neurotrophic factor	Homo sapiens	94-127
23611783-6	2013	A comparative analysis of the sulfation of flavonoids by AtSULT202E1, AtSULT202B1 and AtSULT202A1 revealed that three AtSULTs have differential substrate specificities.	Flavonoids	43-53	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	57-68
23611783-6	2013	A comparative analysis of the sulfation of flavonoids by AtSULT202E1, AtSULT202B1 and AtSULT202A1 revealed that three AtSULTs have differential substrate specificities.	Flavonoids	43-53	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	70-81
23611783-6	2013	A comparative analysis of the sulfation of flavonoids by AtSULT202E1, AtSULT202B1 and AtSULT202A1 revealed that three AtSULTs have differential substrate specificities.	Flavonoids	43-53	sulfotransferase 12	Arabidopsis thaliana	86-97
23611783-9	2013	In conclusion, our studies indicate that a novel AtSULT202E1 has the sulfating activity toward flavonoids together with AtSULT202B1 and AtSULT202A1.	Flavonoids	95-105	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	49-60
23611783-9	2013	In conclusion, our studies indicate that a novel AtSULT202E1 has the sulfating activity toward flavonoids together with AtSULT202B1 and AtSULT202A1.	Flavonoids	95-105	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	120-131
23611783-9	2013	In conclusion, our studies indicate that a novel AtSULT202E1 has the sulfating activity toward flavonoids together with AtSULT202B1 and AtSULT202A1.	Flavonoids	95-105	sulfotransferase 12	Arabidopsis thaliana	136-147
23688533-13	2013	Preliminary evidence indicates that the flavonoid luteolin is a stronger inhibitor of mTOR than rapamycin and is a potent mast cell blocker.	Flavonoids	40-49	mechanistic target of rapamycin kinase	Homo sapiens	86-90
23402418-2	2013	We determined the kinetics of efflux of 13 flavonoid glucuronides using the newly developed HeLa-UGT1A9 cells and correlated them with kinetic parameters derived using expressed UGT1A9.	Flavonoids	43-52	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	97-103
23402418-2	2013	We determined the kinetics of efflux of 13 flavonoid glucuronides using the newly developed HeLa-UGT1A9 cells and correlated them with kinetic parameters derived using expressed UGT1A9.	Flavonoids	43-52	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	178-184
23511019-1	2013	A new series of flavonoid derivatives were designed, synthesized and evaluated as potential multifunctional AChE inhibitors against Alzheimer"s disease.	Flavonoids	16-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
23376017-5	2013	Structurally related flavonoids were tested for their activity on SIRT6, including apigenin, naringenin, luteolin, and kaempferol.	Flavonoids	21-31	sirtuin 6	Homo sapiens	66-71
23435895-6	2013	Arabidopsis mutants of the PRN1 gene, which is involved in abiotic and biotic signaling affecting phenylalanine-derived flavonoids, showed altered susceptibility to cryptoccocal infections, suggesting roles for this pathway in cryptococcal defense.	Flavonoids	120-130	pirin	Arabidopsis thaliana	27-31
23330926-2	2013	The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4"-, C-3", C-6 and C-8- position when there is a single or no hydroxy group on the B-ring.	Flavonoids	19-29	complement C4A (Rodgers blood group)	Homo sapiens	128-131
23614742-9	2013	Likewise, treating fibroblasts with AhR pathway inhibitors, that is, the flavonoids 3-methoxy-4-nitroflavone and alpha-naphthoflavone, blocked the expression of CYP1B1 and MMP-1.	Flavonoids	73-83	aryl hydrocarbon receptor	Homo sapiens	36-39
23330926-2	2013	The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4"-, C-3", C-6 and C-8- position when there is a single or no hydroxy group on the B-ring.	Flavonoids	19-29	complement C3	Homo sapiens	135-138
23330926-2	2013	The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4"-, C-3", C-6 and C-8- position when there is a single or no hydroxy group on the B-ring.	Flavonoids	19-29	complement C6	Homo sapiens	141-144
23330926-2	2013	The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4"-, C-3", C-6 and C-8- position when there is a single or no hydroxy group on the B-ring.	Flavonoids	19-29	homeobox C8	Homo sapiens	149-152
23330928-0	2013	New insights on flavonoid-serum albumin interactions from concerted spectroscopic methods and molecular modeling.	Flavonoids	16-25	albumin	Homo sapiens	32-39
23614742-9	2013	Likewise, treating fibroblasts with AhR pathway inhibitors, that is, the flavonoids 3-methoxy-4-nitroflavone and alpha-naphthoflavone, blocked the expression of CYP1B1 and MMP-1.	Flavonoids	73-83	metalloendoproteinase 2-MMP-like	Nicotiana tabacum	172-177
23471810-0	2013	Effect of flavonoids on circulating levels of TNF-alpha and IL-6 in humans: a systematic review and meta-analysis.	Flavonoids	10-20	tumor necrosis factor	Homo sapiens	46-55
23471810-0	2013	Effect of flavonoids on circulating levels of TNF-alpha and IL-6 in humans: a systematic review and meta-analysis.	Flavonoids	10-20	interleukin 6	Homo sapiens	60-64
23471810-1	2013	Epidemiological or in vitro evidence suggests a potential role for flavonoids as anti-inflammatory agents; we investigated the effect of flavonoids-rich foods or supplements on tumor necrosis factor- alpha (TNF-alpha) and interleukin-6 (IL-6) in long-term placebo-controlled human intervention trials.	Flavonoids	137-147	tumor necrosis factor	Homo sapiens	177-205
23649461-5	2013	Regarding mechanisms, the quercetincontaining flavonoids QGR and QGG differentially targeted compared with quercetin in the NF-kappaB signaling pathway that inhibited the DNA binding activity of the NF-kappaB complex without affecting the degradation and phosphorylation of IkappaBalpha and NF-kappaB phosphorylation.	Flavonoids	46-56	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	274-286
23471810-4	2013	Levels of TNF-alpha decreased after flavonoid consumption in the fixed model only (mean difference (MD) (95% CI): -0.098 (-0.188, -0.009), p = 0.032), but metaregression results showed that neither higher dose, nor a longer duration of intervention were associated with a greater effect size.	Flavonoids	36-45	tumor necrosis factor	Homo sapiens	10-19
23373825-0	2013	Ubiquitin protein ligase 3 mediates the proteasomal degradation of GLABROUS 3 and ENHANCER OF GLABROUS 3, regulators of trichome development and flavonoid biosynthesis in Arabidopsis.	Flavonoids	145-154	HECT ubiquitin protein ligase family protein KAK	Arabidopsis thaliana	0-26
23802436-0	2013	A novel flavonoid isolated from Sophora flavescens exhibited anti-angiogenesis activity, decreased VEGF expression and caused G0/G1 cell cycle arrest in vitro.	Flavonoids	8-17	vascular endothelial growth factor A	Homo sapiens	99-103
23373825-0	2013	Ubiquitin protein ligase 3 mediates the proteasomal degradation of GLABROUS 3 and ENHANCER OF GLABROUS 3, regulators of trichome development and flavonoid biosynthesis in Arabidopsis.	Flavonoids	145-154	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	67-77
23398045-6	2013	Fruit collected from one CHS-silenced line was smaller than the "Royal Gala" controls, lacked flavonoids in the skin and flesh and also had changes in cell morphology.	Flavonoids	94-104	polyketide synthase 5	Malus domestica	25-28
23398045-8	2013	As flavonoids are well known to be key modulators of auxin transport, we hypothesise that the removal of almost all flavonoids from the plant by CHS silencing creates a vastly altered environment for auxin transport to occur and results in the observed changes in growth and development.	Flavonoids	3-13	polyketide synthase 5	Malus domestica	145-148
23373825-0	2013	Ubiquitin protein ligase 3 mediates the proteasomal degradation of GLABROUS 3 and ENHANCER OF GLABROUS 3, regulators of trichome development and flavonoid biosynthesis in Arabidopsis.	Flavonoids	145-154	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	94-104
23398045-8	2013	As flavonoids are well known to be key modulators of auxin transport, we hypothesise that the removal of almost all flavonoids from the plant by CHS silencing creates a vastly altered environment for auxin transport to occur and results in the observed changes in growth and development.	Flavonoids	116-126	polyketide synthase 5	Malus domestica	145-148
23570274-11	2013	The natural flavonoid luteolin inhibits mTOR, mast cells and microglia and could have a significant benefit in ASD.	Flavonoids	12-21	mechanistic target of rapamycin kinase	Homo sapiens	40-44
23535943-8	2013	Significant retardation of fiber growth was observed after the introduction of the F3H-RNA interference segment into the high-flavonoid brown fiber G. hirsutum T586 line by cross.	Flavonoids	126-135	naringenin,2-oxoglutarate 3-dioxygenase	Gossypium hirsutum	83-86
23535943-10	2013	These results suggest that NAR is negatively associated with fiber development and that the metabolism mediated by F3H is important in fiber development, thus highlighting that flavonoid metabolism represents a novel pathway with the potential for cotton fiber improvement.	Flavonoids	177-186	naringenin,2-oxoglutarate 3-dioxygenase	Gossypium hirsutum	115-118
23613820-3	2013	In Arabidopsis thaliana, the oxidative polymerization of flavonoid and biosynthesis of lignin has been demonstrated to be catalyzed by laccase 15, a functional enzyme encoded by the AtTT10 gene.	Flavonoids	57-66	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	182-188
23613820-4	2013	In this study, eight Brassica TT10 genes (three from B. napus, three from B. rapa and two from B. oleracea) were isolated and their roles in flavonoid oxidation/polymerization and lignin biosynthesis were investigated.	Flavonoids	141-150	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	30-34
23434549-7	2013	The application of this type of flavonoid as a tyrosinase inhibitor will lead to significant advances in the field of depigmentation.	Flavonoids	32-41	tyrosinase	Homo sapiens	47-57
23370792-7	2013	The effects of these two flavonoids on the activity and expression of the hepatic LDL receptor (LDLR) were further investigated in HepG2 cells.	Flavonoids	25-35	low density lipoprotein receptor	Homo sapiens	82-94
23370792-7	2013	The effects of these two flavonoids on the activity and expression of the hepatic LDL receptor (LDLR) were further investigated in HepG2 cells.	Flavonoids	25-35	low density lipoprotein receptor	Homo sapiens	96-100
23601649-6	2013	Furthermore, we report that this flavonoid inhibits a single step in the sumoylation cascade: the transfer of SUMO from the E2 enzyme (Ubc9) thioester conjugate to the substrate.	Flavonoids	33-42	ubiquitin conjugating enzyme E2 I	Homo sapiens	124-133
23601649-6	2013	Furthermore, we report that this flavonoid inhibits a single step in the sumoylation cascade: the transfer of SUMO from the E2 enzyme (Ubc9) thioester conjugate to the substrate.	Flavonoids	33-42	ubiquitin conjugating enzyme E2 I	Homo sapiens	135-139
23534413-0	2013	Virtual and in vitro bioassay screening of phytochemical inhibitors from flavonoids and isoflavones against xanthine oxidase and cyclooxygenase-2 for gout treatment.	Flavonoids	73-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-145
23190005-11	2013	CONCLUSION AND IMPLICATIONS: The data indicate that citrus fruit flavonoids are potent and selective blockers of TRPM3.	Flavonoids	65-75	transient receptor potential cation channel, subfamily M, member 3	Mus musculus	113-118
23534413-3	2013	In this study, we report the screening of nine compounds of flavonoids from the ZINC and PubChem databases (containing 2092 flavonoids) using the IGEMDOCK software tool against the xanthine oxidase and cyclooxygenase-2 3D protein structures.	Flavonoids	60-70	prostaglandin-endoperoxide synthase 2	Homo sapiens	202-218
23534413-3	2013	In this study, we report the screening of nine compounds of flavonoids from the ZINC and PubChem databases (containing 2092 flavonoids) using the IGEMDOCK software tool against the xanthine oxidase and cyclooxygenase-2 3D protein structures.	Flavonoids	124-134	prostaglandin-endoperoxide synthase 2	Homo sapiens	202-218
23534413-6	2013	In addition, structure-activity relationships and other important factors of the flavonoids binding to the active site of xanthine oxidase and cyclooxygenase-2 were discussed, which is expected for further rational drug design.	Flavonoids	81-91	prostaglandin-endoperoxide synthase 2	Homo sapiens	143-159
23172919-0	2013	Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.	Flavonoids	0-9	CD38 antigen	Mus musculus	51-55
23369206-12	2013	Screening strategies based on the chemical diversity of natural products have revealed that flavonoids are the most prominent scaffolds possessing NA inhibitory activity.	Flavonoids	92-102	neuraminidase 1	Homo sapiens	147-149
23396969-10	2013	DHA transport activity in GLUT2- and GLUT8-expressing oocytes was inhibited by glucose, fructose, and by the flavonoids phloretin and quercetin.	Flavonoids	109-119	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	26-31
22168126-0	2013	Carbonic anhydrase inhibitors: in vitro inhibition of alpha isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.	Flavonoids	105-115	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	70-92
22168126-0	2013	Carbonic anhydrase inhibitors: in vitro inhibition of alpha isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.	Flavonoids	105-115	carbonic anhydrase 4	Homo sapiens	94-100
22168126-4	2013	The flavonoids inhibited hCA I with K(I)-s in the range of 2.2-12.8 muM, hCA II with K(I)-s in the range of 0.74-6.2 muM, bCA III with K(I)-s in the range of 2.2-21.3 muM, and hCA IV with inhibition constants in the range of 4.4-15.7, with an esterase assay using 4-nitrophenyl acetate as substrate.	Flavonoids	4-14	carbonic anhydrase 4	Homo sapiens	176-182
23277393-1	2013	We have investigated the binding of the biologically important flavonoid fisetin with the carrier protein bovine serum albumin using multi-spectroscopic and molecular docking methods.	Flavonoids	63-72	albumin	Homo sapiens	113-126
23398515-0	2013	Regulation of flavonoid biosynthesis involves an unexpected complex transcriptional regulation of TT8 expression, in Arabidopsis.	Flavonoids	14-23	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	98-101
23396969-10	2013	DHA transport activity in GLUT2- and GLUT8-expressing oocytes was inhibited by glucose, fructose, and by the flavonoids phloretin and quercetin.	Flavonoids	109-119	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	37-42
23396969-12	2013	Furthermore, dietary sugars and flavonoids in fruits and vegetables may modulate Asc bioavailability via inhibition of small intestinal GLUT2 and GLUT8.	Flavonoids	32-42	steroid sulfatase	Mus musculus	81-84
23396969-12	2013	Furthermore, dietary sugars and flavonoids in fruits and vegetables may modulate Asc bioavailability via inhibition of small intestinal GLUT2 and GLUT8.	Flavonoids	32-42	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	136-141
23396969-12	2013	Furthermore, dietary sugars and flavonoids in fruits and vegetables may modulate Asc bioavailability via inhibition of small intestinal GLUT2 and GLUT8.	Flavonoids	32-42	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	146-151
23223784-5	2013	In the artificial mixtures the bioavailability could be increased to 90% when the concentration of flavonoids was increased to 90 muM.	Flavonoids	99-109	latexin	Homo sapiens	130-133
23261528-0	2013	Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.	Flavonoids	155-164	negative elongation factor complex member C/D, Th1l	Mus musculus	14-17
23261528-0	2013	Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.	Flavonoids	155-164	signal transducer and activator of transcription 1	Mus musculus	52-57
23261528-0	2013	Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.	Flavonoids	155-164	signal transducer and activator of transcription 3	Mus musculus	62-67
23567828-6	2013	The total flavonoid content was assessed by spectrophotometric determination, and the results ranged between 572.08 and 1,102.99 mug mL-1.	Flavonoids	10-19	L1 cell adhesion molecule	Mus musculus	133-137
23112005-11	2013	These results indicate that CYP2A6.25 possessed new substrate specificity toward flavonoids.	Flavonoids	81-91	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	28-34
23440277-5	2013	In a screen of biological metabolites, we have now identified four flavonoids as potentiators of EAG1 channels: fisetin, quercetin, luteolin, and kaempferol.	Flavonoids	67-77	potassium voltage-gated channel subfamily H member 1	Homo sapiens	97-101
23440277-9	2013	However, in fluorescence resonance energy transfer and anisotropy-based binding assays, flavonoids bound to the purified CNBHD of EAG1 channels.	Flavonoids	88-98	potassium voltage-gated channel subfamily H member 1	Homo sapiens	130-134
23440277-13	2013	These results suggest that the flavonoids identified here potentiated EAG1 channels by binding to the CNBHD, possibly by displacing their intrinsic ligand.	Flavonoids	31-41	potassium voltage-gated channel subfamily H member 1	Homo sapiens	70-74
23440277-14	2013	EAG1 channels should be considered as a possible target for the physiological effects of flavonoids.	Flavonoids	89-99	potassium voltage-gated channel subfamily H member 1	Homo sapiens	0-4
23411073-0	2013	Flavonoids as receptor tyrosine kinase FLT3 inhibitors.	Flavonoids	0-10	fms related receptor tyrosine kinase 3	Homo sapiens	39-43
24170973-4	2013	Two derivatives of the flavonoid quercetin (Q), chloronaphthoquinone quercetin (CNC) and monochloropivaloyl quercetin (MCP), showed improved antioxidant properties and moreover, they efficiently inhibited aldose reductase activity in vitro.	Flavonoids	23-32	aldo-keto reductase family 1 member B1	Rattus norvegicus	205-221
23440277-0	2013	Flavonoid regulation of EAG1 channels.	Flavonoids	0-9	potassium voltage-gated channel subfamily H member 1	Homo sapiens	24-28
22749133-0	2013	The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation.	Flavonoids	4-14	mitogen-activated protein kinase 8	Homo sapiens	151-154
23294286-0	2013	A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK/Nrf2 pathway.	Flavonoids	22-31	heme oxygenase 1	Mus musculus	65-81
23294286-0	2013	A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK/Nrf2 pathway.	Flavonoids	22-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	109-113
23254473-6	2013	In animal models, citrus flavonoid supplements prevent hepatic steatosis, dyslipidemia and insulin sensitivity primarily through inhibition of hepatic fatty acid synthesis and increased fatty acid oxidation.	Flavonoids	25-34	insulin	Homo sapiens	91-98
23254473-10	2013	SUMMARY: These recent studies suggest an important role of citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity and atherosclerosis.	Flavonoids	66-76	insulin	Homo sapiens	111-118
22749133-0	2013	The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation.	Flavonoids	4-14	mitogen-activated protein kinase 1	Homo sapiens	159-162
23192864-9	2013	Moreover, the flavonoids equol and quercetin exhibited interaction with all ruminant ABCG2 clones.	Flavonoids	14-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	85-90
23188647-0	2013	Flavonoids and polymer derivatives as CYP3A4 inhibitors for improved oral drug bioavailability.	Flavonoids	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-44
22749133-0	2013	The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation.	Flavonoids	4-14	tumor protein p53	Homo sapiens	167-174
23188647-4	2013	Comparing results obtained from a known CYP3A4 inhibitor, verapamil, the flavonoids inhibited felodipine metabolism.	Flavonoids	73-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46
23188647-5	2013	In-depth computational analysis of these flavonoids in terms of CYP3A4 binding, sequencing, and affinity, computational biomimetism was employed to validate the potential CYP3A4 inhibitors.	Flavonoids	41-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-70
22749133-2	2013	The present study aimed to characterize the metabolism and further antiproliferative activity of the natural flavonoid diosmetin in the CYP1-expressing human hepatoma cell line HepG2.	Flavonoids	109-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	136-140
23188647-5	2013	In-depth computational analysis of these flavonoids in terms of CYP3A4 binding, sequencing, and affinity, computational biomimetism was employed to validate the potential CYP3A4 inhibitors.	Flavonoids	41-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	171-177
22274938-7	2013	Further, the transcript expression of two important genes encoding dihydroflavonol reductase (DFR) and phenylalanine ammonia lyase regulatory enzymes of flavonoid biosynthesis pathway was analyzed.	Flavonoids	153-162	cinnamoyl-CoA reductase 1-like	Nicotiana tabacum	67-92
22274938-7	2013	Further, the transcript expression of two important genes encoding dihydroflavonol reductase (DFR) and phenylalanine ammonia lyase regulatory enzymes of flavonoid biosynthesis pathway was analyzed.	Flavonoids	153-162	cinnamoyl-CoA reductase 1-like	Nicotiana tabacum	94-97
22274938-1	2013	This study was aimed at to check the influence of human lactoferrin (hLF) expression on iron homeostasis, flavonoids, and antioxidants in transgenic tobacco.	Flavonoids	106-116	HLF transcription factor, PAR bZIP family member	Homo sapiens	69-72
22274938-9	2013	Total phenolics, flavonoids, and proanthocyanidins contents were found to be higher in hLF transgenic tobacco than the mock and untransformed wild plant.	Flavonoids	17-27	HLF transcription factor, PAR bZIP family member	Homo sapiens	87-90
22274938-10	2013	Results suggest that hLF expression in transgenic tobacco leads to iron deficiency, downregulation of antioxidant enzymes, and increase in total flavonoids.	Flavonoids	145-155	HLF transcription factor, PAR bZIP family member	Homo sapiens	21-24
23135489-0	2013	Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation             of anti-apoptotic proteins and death receptor 5 in colon cancer cells.	Flavonoids	12-21	TNF superfamily member 10	Homo sapiens	35-40
23255485-0	2013	Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.	Flavonoids	8-17	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
23255485-0	2013	Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.	Flavonoids	8-17	mitogen-activated protein kinase 3	Homo sapiens	89-93
23255485-0	2013	Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.	Flavonoids	8-17	proline rich transmembrane protein 2	Homo sapiens	98-101
23934345-0	2013	6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells.	Flavonoids	48-57	Eph receptor B1	Rattus norvegicus	68-105
23153457-2	2013	In this study we tested to what extent two ERbeta agonists, androgen derivative 3beta-Adiol and flavonoid Liquiritigenin, would affect growth and gene expression of different ERbeta-positive human breast cancer cell lines.	Flavonoids	96-105	estrogen receptor 2	Homo sapiens	175-181
23153457-7	2013	In MCF-7 cells, the highest dose of this flavonoid exerted proliferative effects accompanied by increased expression of cyclin B1, PR and PS2, indicating unspecific activation of ERalpha.	Flavonoids	41-50	cyclin B1	Homo sapiens	120-129
23153457-7	2013	In MCF-7 cells, the highest dose of this flavonoid exerted proliferative effects accompanied by increased expression of cyclin B1, PR and PS2, indicating unspecific activation of ERalpha.	Flavonoids	41-50	trefoil factor 1	Homo sapiens	138-141
23153457-7	2013	In MCF-7 cells, the highest dose of this flavonoid exerted proliferative effects accompanied by increased expression of cyclin B1, PR and PS2, indicating unspecific activation of ERalpha.	Flavonoids	41-50	estrogen receptor 1	Homo sapiens	179-186
23142567-2	2013	We describe here the binding of quercetagetin (3,3",4",5,6,7-hydroxyflavone), related flavonoids, and SP600125 to JNK1 and PI3-K by ATP-competitive and immobilized metal ion affinity-based fluorescence polarization assays and measure the effect of quercetagetin on JNK1 and PI3-K activities.	Flavonoids	86-96	mitogen-activated protein kinase 8	Mus musculus	114-118
23142567-2	2013	We describe here the binding of quercetagetin (3,3",4",5,6,7-hydroxyflavone), related flavonoids, and SP600125 to JNK1 and PI3-K by ATP-competitive and immobilized metal ion affinity-based fluorescence polarization assays and measure the effect of quercetagetin on JNK1 and PI3-K activities.	Flavonoids	86-96	mitogen-activated protein kinase 8	Mus musculus	265-269
23344202-0	2013	Total flavonoids of Scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in vitro.	Flavonoids	6-16	TIMP metallopeptidase inhibitor 1	Homo sapiens	84-88
23117658-3	2013	These effects of warfarin can be completely reversed by intraperitoneal administration of the TG2-specific inhibitor KCC-009 or dietary supplementation with the bioflavonoid quercetin, known to inhibit beta-catenin signaling.	Flavonoids	161-173	catenin beta 1	Rattus norvegicus	202-214
23223575-4	2013	However, beta-catenin activity is important because inhibition of beta-catenin with shRNA or bioflavonoid quercetin prevents calcification in primary human VSMCs, rodent aortic rings, and rat A10 VSMC line.	Flavonoids	93-105	catenin beta 1	Homo sapiens	9-21
23199735-3	2013	The inhibition activity of the nine flavonoid compounds and gallic acid against MMP1ca was examined.	Flavonoids	36-45	matrix metallopeptidase 1	Homo sapiens	80-84
23995665-6	2013	AKR1C5 was potently and competitively inhibited by flavonoids such as kaempferol and quercetin, suggesting that its activity is affected by ingested flavonoids.	Flavonoids	51-61	prostaglandin-E(2) 9-reductase	Oryctolagus cuniculus	0-6
23995665-6	2013	AKR1C5 was potently and competitively inhibited by flavonoids such as kaempferol and quercetin, suggesting that its activity is affected by ingested flavonoids.	Flavonoids	149-159	prostaglandin-E(2) 9-reductase	Oryctolagus cuniculus	0-6
23931437-7	2013	2) Coumarins, flavonoids, stilbenes, and other natural products are also important AChE inhibitors from natural products.	Flavonoids	14-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
23448447-10	2013	In this review, we provide a comprehensive overview of breast cancer and chemoprevention by flavonoids, mainly focusing on ER-mediated hormonal regulation, redox cycling of estrogen metabolites, and selective inhibition of CYP1B1.	Flavonoids	92-102	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	223-229
23931275-2	2013	Specific examples discussed here include the interaction of estrogens with human protein disulfide isomerase (PDI) and its pancreas-specific homolog (PDIp), and the interaction of dietary flavonoids with human cyclooxygenase (COX) I and II.	Flavonoids	188-198	prolyl 4-hydroxylase subunit beta	Homo sapiens	150-154
23841225-4	2013	The results showed that characteristic product ions distinguishing flavonoids glycosylated with rhamnosyl-(alpha1 --&gt; 2)-glucosyl from isomeric flavonoids glycosylated with rhamnosyl-(alpha1 --&gt; 6)-glucosyl were the precursor ion [M-H]- and its characteristic product ions Y0- and [0.2X0-H]-.	Flavonoids	67-77	adrenoceptor alpha 1D	Homo sapiens	107-113
23841225-4	2013	The results showed that characteristic product ions distinguishing flavonoids glycosylated with rhamnosyl-(alpha1 --&gt; 2)-glucosyl from isomeric flavonoids glycosylated with rhamnosyl-(alpha1 --&gt; 6)-glucosyl were the precursor ion [M-H]- and its characteristic product ions Y0- and [0.2X0-H]-.	Flavonoids	67-77	adrenoceptor alpha 1D	Homo sapiens	187-193
23840275-1	2013	We revealed the cytotoxic effect of the flavonoid, fisetin (FIS), on human COLO205 colon cancer cells in the presence and absence of the HSP90 inhibitors, geldanamycin (GA) and radicicol (RAD).	Flavonoids	40-49	long intergenic non-protein coding RNA 1554	Homo sapiens	60-63
23878590-0	2013	Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor.	Flavonoids	0-10	estrogen receptor 1	Rattus norvegicus	131-148
24058373-8	2013	Taken together, this synergistic effect of baicalein and daidzein might serve as a method to improve the therapeutic efficacy of different flavonoids against A beta , which might be crucial in developing those flavonoidsin treating Alzheimer"s disease in the future.	Flavonoids	139-149	amyloid beta precursor protein	Homo sapiens	158-164
23878590-8	2013	In cultured astrocytes, the phosphorylation of estrogen receptor was triggered by application of flavonoids.	Flavonoids	97-107	estrogen receptor 1	Rattus norvegicus	47-64
23878590-9	2013	The phosphorylation was blocked by an inhibitor of estrogen receptor, which in parallel reduced the flavonoid-induced expression of neurotrophic factors.	Flavonoids	100-109	estrogen receptor 1	Rattus norvegicus	51-68
23573138-0	2013	Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).	Flavonoids	64-74	solute carrier family 22 member 6	Homo sapiens	116-123
24348728-5	2013	Furthermore, the flavonoids decreased production of inflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6, and tumor necrosis factor-alpha and inhibited phosphorylation of nuclear factor-kappa B (NF- kappa B) and mitogen-activated protein kinases (MAPKs) in LPS-induced RAW 264.7 cells.	Flavonoids	17-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	238-249
24348728-8	2013	These findings suggest that the flavonoids isolated from S. baicalensis G. might have anti-inflammatory effects that regulate the expression of inflammatory mediators by inhibiting the NF- kappa B signaling pathway via the MAPK signaling pathway in RAW 264.7 cells.	Flavonoids	32-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	185-196
24348728-0	2013	Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF- kappa B and MAPK in RAW 264.7 Cells.	Flavonoids	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-136
24348728-5	2013	Furthermore, the flavonoids decreased production of inflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6, and tumor necrosis factor-alpha and inhibited phosphorylation of nuclear factor-kappa B (NF- kappa B) and mitogen-activated protein kinases (MAPKs) in LPS-induced RAW 264.7 cells.	Flavonoids	17-27	prostaglandin-endoperoxide synthase 2	Mus musculus	116-132
24348728-5	2013	Furthermore, the flavonoids decreased production of inflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6, and tumor necrosis factor-alpha and inhibited phosphorylation of nuclear factor-kappa B (NF- kappa B) and mitogen-activated protein kinases (MAPKs) in LPS-induced RAW 264.7 cells.	Flavonoids	17-27	interleukin 6	Mus musculus	134-147
24348728-5	2013	Furthermore, the flavonoids decreased production of inflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6, and tumor necrosis factor-alpha and inhibited phosphorylation of nuclear factor-kappa B (NF- kappa B) and mitogen-activated protein kinases (MAPKs) in LPS-induced RAW 264.7 cells.	Flavonoids	17-27	tumor necrosis factor	Mus musculus	153-180
23554829-10	2013	The results of this study into the phosphorylation of ERK 1/2 and p38MAPK by flavonoids suggest that the inhibition of p38MAPK phosphorylation may effectively enhance neurite outgrowth.	Flavonoids	77-87	mitogen activated protein kinase 3	Rattus norvegicus	54-61
23573138-0	2013	Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).	Flavonoids	64-74	solute carrier family 22 member 8	Homo sapiens	129-136
23573138-0	2013	Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).	Flavonoids	64-74	solute carrier family 22 member 11	Homo sapiens	146-154
23662114-5	2013	Utilizing flow cytometry, we identified five cyclohexylmethyl flavonoids that can inhibit propagation of NANOG-positive cells in both breast cancer MCF-7 and MDA-MB231 cells.	Flavonoids	62-72	Nanog homeobox	Homo sapiens	105-110
23662114-6	2013	Among these flavonoids, ugonins J and K were found to be able to induce apoptosis in non-CSC populations and to reduce self-renewal growth of CD24(-/low)CD44(+) CSC population.	Flavonoids	12-22	CD24 molecule	Homo sapiens	142-146
23662114-6	2013	Among these flavonoids, ugonins J and K were found to be able to induce apoptosis in non-CSC populations and to reduce self-renewal growth of CD24(-/low)CD44(+) CSC population.	Flavonoids	12-22	CD44 molecule (Indian blood group)	Homo sapiens	153-157
22864626-5	2013	Although little is known about binding of some flavonoids and steroids at the NBD (nucleotide binding domain) of P-gp in the vicinity of ATP binding site inhibiting its hydrolysis, a valid explanation of how P-gp accommodates such a diverse set of inhibitors is still awaited.	Flavonoids	47-57	PGP	Canis lupus familiaris	113-117
23662114-9	2013	We therefore conclude that cyclohexylmethyl flavonoids can possibly be utilized to suppress the propagation of breast CSCs via reduction of NANOG.	Flavonoids	44-54	Nanog homeobox	Homo sapiens	140-145
24266406-4	2013	This study describes the effect of the flavonoid biochanin A (BCA), administered alone or in combination with gamma radiation, on the growth of radioresistant human colon cancer HT29 cells in vitro.	Flavonoids	39-48	B cell linker	Homo sapiens	49-60
24266406-4	2013	This study describes the effect of the flavonoid biochanin A (BCA), administered alone or in combination with gamma radiation, on the growth of radioresistant human colon cancer HT29 cells in vitro.	Flavonoids	39-48	B cell linker	Homo sapiens	62-65
23054592-4	2013	The flavonoid derivative 7,8 DHF acts a potent TrkB agonist and upregulates the downstream AKT and MAPK/ERK survival signaling pathways in a TrkB-dependent manner in both primary rat RGCs as well as the RGC-5 cell line.	Flavonoids	4-13	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	47-51
23054592-4	2013	The flavonoid derivative 7,8 DHF acts a potent TrkB agonist and upregulates the downstream AKT and MAPK/ERK survival signaling pathways in a TrkB-dependent manner in both primary rat RGCs as well as the RGC-5 cell line.	Flavonoids	4-13	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
23054592-4	2013	The flavonoid derivative 7,8 DHF acts a potent TrkB agonist and upregulates the downstream AKT and MAPK/ERK survival signaling pathways in a TrkB-dependent manner in both primary rat RGCs as well as the RGC-5 cell line.	Flavonoids	4-13	Eph receptor B1	Rattus norvegicus	104-107
23054592-4	2013	The flavonoid derivative 7,8 DHF acts a potent TrkB agonist and upregulates the downstream AKT and MAPK/ERK survival signaling pathways in a TrkB-dependent manner in both primary rat RGCs as well as the RGC-5 cell line.	Flavonoids	4-13	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	141-145
23737836-0	2013	Optimizing combinations of flavonoids deriving from astragali radix in activating the regulatory element of erythropoietin by a feedback system control scheme.	Flavonoids	27-37	erythropoietin	Homo sapiens	108-122
23737836-3	2013	Out of more than one thousand possible combinations, only tens of trials were required to optimize the flavonoid combinations that stimulated a maximal transcriptional activity of hypoxia response element (HRE), a critical regulator for erythropoietin (EPO) transcription, in cultured human embryonic kidney fibroblast (HEK293T).	Flavonoids	103-112	erythropoietin	Homo sapiens	237-251
23737836-3	2013	Out of more than one thousand possible combinations, only tens of trials were required to optimize the flavonoid combinations that stimulated a maximal transcriptional activity of hypoxia response element (HRE), a critical regulator for erythropoietin (EPO) transcription, in cultured human embryonic kidney fibroblast (HEK293T).	Flavonoids	103-112	erythropoietin	Homo sapiens	253-256
23737836-5	2013	Our study suggests that the optimized combination of flavonoids may have strong effect in activating the regulatory element of erythropoietin at very low dosage, which may be used as new source of natural hematopoietic agent.	Flavonoids	53-63	erythropoietin	Homo sapiens	127-141
22864626-5	2013	Although little is known about binding of some flavonoids and steroids at the NBD (nucleotide binding domain) of P-gp in the vicinity of ATP binding site inhibiting its hydrolysis, a valid explanation of how P-gp accommodates such a diverse set of inhibitors is still awaited.	Flavonoids	47-57	PGP	Canis lupus familiaris	208-212
23132664-3	2013	Eight major flavonoids (naringin, naringenin, hesperidin, hesperetin, phloridzin, phloretin, quercetin, and kaempferol) contained in the juices inhibited OATP2B1-mediated estrone-3-sulfate uptake with IC(50) values of 4.63, 49.2, 1.92, 67.6, 23.2, 1.31, 9.47, and 21.3 microM, respectively.	Flavonoids	12-22	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	154-161
21546228-3	2013	We therefore investigated the possible role of bilitranslocase (TC 2.A.65.1.1), an endothelial plasma membrane carrier that transports flavonoids, in the vasodilation activity induced by anthocyanins.	Flavonoids	135-145	ceruloplasmin	Rattus norvegicus	47-62
23054013-5	2013	We studied the role of the flavonoids fisetin, luteolin, myricetin, and morin in inhibiting the activation of mitogen-activated protein kinase (MAPK) and AKT as well as their role in lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2) transcription.	Flavonoids	27-37	AKT serine/threonine kinase 1	Homo sapiens	154-157
23054013-6	2013	All four of these flavonoids were found to inhibit MAPK and AKT.	Flavonoids	18-28	AKT serine/threonine kinase 1	Homo sapiens	60-63
23054013-8	2013	All of these flavonoids also blocked LPS-mediated COX-2 expression.	Flavonoids	13-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	50-55
23840918-4	2013	In nongestational tissues, dietary flavonoids such as luteolin and kaempferol inhibit NF-kappaB, AP-1, and their downstream targets.	Flavonoids	35-45	nuclear factor kappa B subunit 1	Homo sapiens	86-95
23035855-0	2013	Effects of total flavonoids from Dracocephalum moldavica on the proliferation, migration, and adhesion molecule expression of rat vascular smooth muscle cells induced by TNF-alpha.	Flavonoids	17-27	tumor necrosis factor	Rattus norvegicus	170-179
23035855-7	2013	RESULTS: Total flavonoids (IC(50) = 145.63 mug/mL) significantly inhibited tumor necrosis factor-alpha (TNF-alpha) induced VSMC proliferation at concentrations of 25, 50, and 100 mug/mL.	Flavonoids	15-25	tumor necrosis factor	Rattus norvegicus	104-113
23035855-8	2013	Treatment with 50 and 100 mug/mL of total flavonoids also significantly inhibited TNF-alpha-induced VSMC migration, whereas 25 mug/mL of total flavonoids did not elicit any significant inhibitory effect.	Flavonoids	42-52	tumor necrosis factor	Rattus norvegicus	82-91
23035855-9	2013	In addition, the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining, showing that TNF-alpha-induced expression of PCNA, NF-kappaB p65, ICAM-1, and VCAM-1 in VSMCs was dose-dependently suppressed by total flavonoids.	Flavonoids	34-44	tumor necrosis factor	Rattus norvegicus	149-158
23035855-9	2013	In addition, the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining, showing that TNF-alpha-induced expression of PCNA, NF-kappaB p65, ICAM-1, and VCAM-1 in VSMCs was dose-dependently suppressed by total flavonoids.	Flavonoids	271-281	tumor necrosis factor	Rattus norvegicus	149-158
24080610-2	2013	Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the activation of ghrelin receptor in vitro.	Flavonoids	43-52	growth hormone secretagogue receptor	Rattus norvegicus	109-125
23418608-5	2013	In isolated mouse pancreatic acinar cells, TNF-alpha stimulation increased IL-33 release while IL-33 stimulation increased proinflammatory cytokine release, both involving the ERK MAP kinase pathway; the flavonoid luteolin inhibited IL-33-stimulated IL-6 and CCL2/MCP-1 release.	Flavonoids	204-213	interleukin 33	Mus musculus	95-100
23437066-12	2013	Subsequently, these flavonoids inhibited the expression of tumor necrosis factor alpha, interleukin 1beta, intercellular adhesion molecule 1, matrix metallopeptidase 9, inducible nitric oxide synthase, and myeloperoxidase.	Flavonoids	20-30	tumor necrosis factor	Rattus norvegicus	59-86
23431365-3	2013	We and others have shown that several anticancer agents and flavonoids overcome resistance to Apo2L/TRAIL by upregulating death receptor 5 (DR5) in malignant tumor cells.	Flavonoids	60-70	TNF superfamily member 10	Homo sapiens	94-99
23418608-5	2013	In isolated mouse pancreatic acinar cells, TNF-alpha stimulation increased IL-33 release while IL-33 stimulation increased proinflammatory cytokine release, both involving the ERK MAP kinase pathway; the flavonoid luteolin inhibited IL-33-stimulated IL-6 and CCL2/MCP-1 release.	Flavonoids	204-213	interleukin 33	Mus musculus	95-100
23431365-3	2013	We and others have shown that several anticancer agents and flavonoids overcome resistance to Apo2L/TRAIL by upregulating death receptor 5 (DR5) in malignant tumor cells.	Flavonoids	60-70	TNF superfamily member 10	Homo sapiens	100-105
23437066-12	2013	Subsequently, these flavonoids inhibited the expression of tumor necrosis factor alpha, interleukin 1beta, intercellular adhesion molecule 1, matrix metallopeptidase 9, inducible nitric oxide synthase, and myeloperoxidase.	Flavonoids	20-30	interleukin 1 beta	Rattus norvegicus	88-140
23437066-12	2013	Subsequently, these flavonoids inhibited the expression of tumor necrosis factor alpha, interleukin 1beta, intercellular adhesion molecule 1, matrix metallopeptidase 9, inducible nitric oxide synthase, and myeloperoxidase.	Flavonoids	20-30	matrix metallopeptidase 9	Rattus norvegicus	142-167
23431365-3	2013	We and others have shown that several anticancer agents and flavonoids overcome resistance to Apo2L/TRAIL by upregulating death receptor 5 (DR5) in malignant tumor cells.	Flavonoids	60-70	TNF receptor superfamily member 10b	Homo sapiens	122-138
23418608-5	2013	In isolated mouse pancreatic acinar cells, TNF-alpha stimulation increased IL-33 release while IL-33 stimulation increased proinflammatory cytokine release, both involving the ERK MAP kinase pathway; the flavonoid luteolin inhibited IL-33-stimulated IL-6 and CCL2/MCP-1 release.	Flavonoids	204-213	interleukin 6	Mus musculus	250-254
23431365-3	2013	We and others have shown that several anticancer agents and flavonoids overcome resistance to Apo2L/TRAIL by upregulating death receptor 5 (DR5) in malignant tumor cells.	Flavonoids	60-70	TNF receptor superfamily member 10b	Homo sapiens	140-143
23437066-12	2013	Subsequently, these flavonoids inhibited the expression of tumor necrosis factor alpha, interleukin 1beta, intercellular adhesion molecule 1, matrix metallopeptidase 9, inducible nitric oxide synthase, and myeloperoxidase.	Flavonoids	20-30	myeloperoxidase	Rattus norvegicus	206-221
23431365-5	2013	Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced apoptosis by upregulation of DR5.	Flavonoids	30-39	solute carrier family 25 member 6	Homo sapiens	68-100
23431365-5	2013	Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced apoptosis by upregulation of DR5.	Flavonoids	30-39	solute carrier family 25 member 6	Homo sapiens	102-106
23431365-5	2013	Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced apoptosis by upregulation of DR5.	Flavonoids	30-39	TNF superfamily member 10	Homo sapiens	137-142
23431365-5	2013	Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced apoptosis by upregulation of DR5.	Flavonoids	30-39	TNF superfamily member 10	Homo sapiens	143-148
23431365-5	2013	Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced apoptosis by upregulation of DR5.	Flavonoids	30-39	TNF receptor superfamily member 10b	Homo sapiens	186-189
23418608-5	2013	In isolated mouse pancreatic acinar cells, TNF-alpha stimulation increased IL-33 release while IL-33 stimulation increased proinflammatory cytokine release, both involving the ERK MAP kinase pathway; the flavonoid luteolin inhibited IL-33-stimulated IL-6 and CCL2/MCP-1 release.	Flavonoids	204-213	chemokine (C-C motif) ligand 2	Mus musculus	259-263
22980808-5	2012	Enzyme kinetic analysis revealed that flavonoids are competitive inhibitors of ACE.	Flavonoids	38-48	angiotensin I converting enzyme	Homo sapiens	79-82
23431365-6	2013	Apigenin and genistein, which are major flavonoids, enhanced Apo2L/TRAIL-induced apoptosis in cancer cells.	Flavonoids	40-50	TNF superfamily member 10	Homo sapiens	61-66
23596884-1	2013	OBJECTIVE: To examine the anti-inflammatory mechanism of total flavonoids of Glycyrrhizae Radix et Rhizoma (TFGR) and its ingredient on IFN-gamma and LPS-induced macrophage RAW264.7.	Flavonoids	63-73	interferon gamma	Homo sapiens	136-145
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	Flavonoids	21-30	interleukin 1 beta	Homo sapiens	120-128
23596884-13	2013	Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.	Flavonoids	21-30	peroxisome proliferator activated receptor gamma	Homo sapiens	179-189
23342093-1	2013	Soybean isoflavone synthase (IFS) and flavanone 3-hydroxylase (F3H) are two key enzymes catalyzing the biosynthesis of isoflavonoids and flavonoids, both of which play diverse roles in stress responses.	Flavonoids	122-132	flavanone 3-hydroxylase	Glycine max	38-61
23342093-1	2013	Soybean isoflavone synthase (IFS) and flavanone 3-hydroxylase (F3H) are two key enzymes catalyzing the biosynthesis of isoflavonoids and flavonoids, both of which play diverse roles in stress responses.	Flavonoids	122-132	flavanone 3-hydroxylase	Glycine max	63-66
22980808-7	2012	Overall, FAE and most of the flavonoids tested showed ACE inhibition in vitro which needs further investigations using animal and human clinical trials.	Flavonoids	29-39	angiotensin I converting enzyme	Homo sapiens	54-57
23182586-5	2012	An ability of some flavonoids to absorb light in PUF phase allows their direct determination by diffuse reflectance spectroscopy.	Flavonoids	19-29	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	49-52
22965624-4	2012	Flavone, a backbone compound of flavonoids, at subinhibitory concentration (50 mug/mL), markedly reduced the production of staphyloxanthin and alpha-hemolysin.	Flavonoids	32-42	AT695_RS11870	Staphylococcus aureus	143-158
23238999-0	2012	Epimedium-derived flavonoids modulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats via Wnt/beta-catenin signal pathway activation.	Flavonoids	18-28	Wnt family member 2	Rattus norvegicus	172-175
23238999-0	2012	Epimedium-derived flavonoids modulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats via Wnt/beta-catenin signal pathway activation.	Flavonoids	18-28	catenin beta 1	Rattus norvegicus	176-188
23238999-1	2012	OBJECTIVE: To observe the function of wnt/beta-catenin signal pathway on the process that epimedium-derived flavonoids (EFs) regulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats, and to provide an experimental evidence for the mechanism of EFs on treating postmenopausal osteoporosis.	Flavonoids	108-118	Wnt family member 2	Rattus norvegicus	38-41
23238999-1	2012	OBJECTIVE: To observe the function of wnt/beta-catenin signal pathway on the process that epimedium-derived flavonoids (EFs) regulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats, and to provide an experimental evidence for the mechanism of EFs on treating postmenopausal osteoporosis.	Flavonoids	108-118	catenin beta 1	Rattus norvegicus	42-54
23477145-4	2012	RESULT: Total flavonoids contained in Yushen Tang showed the effects in inhibiting hydrogen peroxide-induced human umbilical vein endothelial cell (HUVEC) injury and down-regulating PAI-1 expression (P&lt;0.05).	Flavonoids	14-24	serpin family E member 1	Homo sapiens	182-187
22998389-0	2012	Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences.	Flavonoids	58-68	glutathione S-transferase kappa 1	Homo sapiens	28-54
22998389-1	2012	Many studies reviewed herein demonstrated the potency of some flavonoids to modulate the activity and/or expression of glutathione S-transferases (GSTs).	Flavonoids	62-72	glutathione S-transferase kappa 1	Homo sapiens	119-145
22998389-1	2012	Many studies reviewed herein demonstrated the potency of some flavonoids to modulate the activity and/or expression of glutathione S-transferases (GSTs).	Flavonoids	62-72	glutathione S-transferase kappa 1	Homo sapiens	147-151
22998389-3	2012	The effect of flavonoids on GSTs strongly depends on flavonoid structure, concentration, period of administration, as well as on GST isoform and origin.	Flavonoids	14-24	glutathione S-transferase kappa 1	Homo sapiens	28-32
22998389-3	2012	The effect of flavonoids on GSTs strongly depends on flavonoid structure, concentration, period of administration, as well as on GST isoform and origin.	Flavonoids	14-23	glutathione S-transferase kappa 1	Homo sapiens	28-32
22953828-0	2012	The influence of flavonoids on the binding of pantoprazole to bovine serum albumin by spectroscopic methods: with the viewpoint of food/drug interference.	Flavonoids	17-27	albumin	Homo sapiens	69-82
22989100-2	2012	On the other hand, quercetin, a natural flavonoid is a potent antioxidant and activator of superoxide dismutase and catalase.	Flavonoids	40-49	catalase	Rattus norvegicus	116-124
22932446-1	2012	This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism.	Flavonoids	69-78	TNF superfamily member 10	Homo sapiens	93-130
22932446-1	2012	This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism.	Flavonoids	69-78	TNF superfamily member 10	Homo sapiens	132-137
22422552-1	2012	The natural flavonoid quercetin is a low affinity ligand of the aryl hydrocarbon receptor (AhR), a transcription factor regulating the expression of cytochrome P450 (CYP) 1A enzymes.	Flavonoids	12-21	aryl hydrocarbon receptor	Homo sapiens	64-89
22772804-0	2012	The interaction of flavonoid-lysozyme and the relationship between molecular structure of flavonoids and their binding activity to lysozyme.	Flavonoids	19-28	lysozyme	Homo sapiens	29-37
22772804-0	2012	The interaction of flavonoid-lysozyme and the relationship between molecular structure of flavonoids and their binding activity to lysozyme.	Flavonoids	19-28	lysozyme	Homo sapiens	131-139
22772804-0	2012	The interaction of flavonoid-lysozyme and the relationship between molecular structure of flavonoids and their binding activity to lysozyme.	Flavonoids	90-100	lysozyme	Homo sapiens	29-37
22772804-0	2012	The interaction of flavonoid-lysozyme and the relationship between molecular structure of flavonoids and their binding activity to lysozyme.	Flavonoids	90-100	lysozyme	Homo sapiens	131-139
22772804-1	2012	In this work, the interactions of twelve structurally different flavonoids with Lysozyme (Lys) were studied by fluorescence quenching method.	Flavonoids	64-74	lysozyme	Homo sapiens	80-88
22935448-5	2012	We also discuss the recent progress in the identification of novel chemical inhibitors of nsP13 in the context of our recent discovery of the strong inhibition of the SARS helicase by natural flavonoids, myricetin and scutellarein.	Flavonoids	192-202	helicase for meiosis 1	Homo sapiens	172-180
22801419-5	2012	The estimated thermodynamic parameters suggest that the main intermolecular interaction is hydrophobic association, although hydrogen bonds between flavonoids and the active gorge of the acetylcholinesterase molecule seem to occur and have a great impact on acetylcholinesterase inhibition.	Flavonoids	148-158	acetylcholinesterase	Rattus norvegicus	187-207
22801419-5	2012	The estimated thermodynamic parameters suggest that the main intermolecular interaction is hydrophobic association, although hydrogen bonds between flavonoids and the active gorge of the acetylcholinesterase molecule seem to occur and have a great impact on acetylcholinesterase inhibition.	Flavonoids	148-158	acetylcholinesterase	Rattus norvegicus	258-278
22422552-1	2012	The natural flavonoid quercetin is a low affinity ligand of the aryl hydrocarbon receptor (AhR), a transcription factor regulating the expression of cytochrome P450 (CYP) 1A enzymes.	Flavonoids	12-21	aryl hydrocarbon receptor	Homo sapiens	91-94
22842463-2	2012	Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-kappaB) pathway.	Flavonoids	29-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	164-173
23373222-0	2012	[Activating effect of citrus flavonoids on neuromedin U2 receptor and analysis on siRNA interference].	Flavonoids	29-39	neuromedin U receptor 2	Homo sapiens	43-65
23373222-2	2012	METHOD: NMU2R cells were used to observe the activating effect of nine nine citrus flavonoids on NMU2R cell.	Flavonoids	83-93	neuromedin U receptor 2	Homo sapiens	8-13
23373222-2	2012	METHOD: NMU2R cells were used to observe the activating effect of nine nine citrus flavonoids on NMU2R cell.	Flavonoids	83-93	neuromedin U receptor 2	Homo sapiens	97-102
23373222-4	2012	RESULT: Hesperidin and nobiletin contained in citrus flavonoids were found to effectively activate NMU2R.	Flavonoids	53-63	neuromedin U receptor 2	Homo sapiens	99-104
23373222-6	2012	CONCLUSION: Hesperidin and nobiletin contained in citrus flavonoids can activate NMU2R.	Flavonoids	57-67	neuromedin U receptor 2	Homo sapiens	81-86
23009399-0	2012	Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria.	Flavonoids	58-68	monoamine oxidase A	Mus musculus	94-113
23009399-1	2012	Quercetin, a typical dietary flavonoid, is thought to exert antidepressant effects by inhibiting the monoamine oxidase-A (MAO-A) reaction, which is responsible for regulation of the metabolism of the neurotransmitter 5-hydroxytryptamine (5-HT) in the brain.	Flavonoids	29-38	monoamine oxidase A	Mus musculus	101-120
23009399-1	2012	Quercetin, a typical dietary flavonoid, is thought to exert antidepressant effects by inhibiting the monoamine oxidase-A (MAO-A) reaction, which is responsible for regulation of the metabolism of the neurotransmitter 5-hydroxytryptamine (5-HT) in the brain.	Flavonoids	29-38	monoamine oxidase A	Mus musculus	122-127
22292767-1	2012	The natural flavonoids as human digestive enzymes, such as alpha-glucosidase, alpha-amylase and aldose reductases inhibitors, have attracted great interest among researchers.	Flavonoids	12-22	sucrase-isomaltase	Homo sapiens	59-76
22846602-4	2012	Certain dietary flavonoids have been shown to upregulate the expression of adenosine monophosphate-activated protein kinase (AMPK).	Flavonoids	16-26	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	75-123
22846602-4	2012	Certain dietary flavonoids have been shown to upregulate the expression of adenosine monophosphate-activated protein kinase (AMPK).	Flavonoids	16-26	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	125-129
22902988-11	2012	Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose.	Flavonoids	20-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-77
22902988-11	2012	Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose.	Flavonoids	20-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
22583399-3	2012	Plant-origin polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-glycoprotein, MRP1 and BCRP.	Flavonoids	44-54	ATP binding cassette subfamily C member 1	Homo sapiens	206-210
22583399-3	2012	Plant-origin polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-glycoprotein, MRP1 and BCRP.	Flavonoids	44-54	BCR pseudogene 1	Homo sapiens	215-219
25969771-8	2013	The study has also concluded that L16 orthogonal design of experiment is an effective method for the extraction of flavonoid than the shake flask method.	Flavonoids	115-124	immunoglobulin kappa variable 3D-15	Homo sapiens	34-37
23369170-0	2012	Versatile inhibitory effects of the flavonoid-derived PI3K/Akt inhibitor, LY294002, on ATP-binding cassette transporters that characterize stem cells.	Flavonoids	36-45	AKT serine/threonine kinase 1	Homo sapiens	59-62
23369170-12	2012	It is known that many flavonoids are inhibitors of BCRP and PI3K.	Flavonoids	22-32	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	51-55
22292767-4	2012	The hydroxylation on A-ring of flavones and isoflavones, especially at C-5 and C-7, significantly enhanced the inhibitory activities against digestive enzymes and the hydroxylation on positions C-3" and C-4" of B-ring of flavonoids remarkably improved the inhibition.	Flavonoids	221-231	complement C5	Homo sapiens	71-74
22292767-4	2012	The hydroxylation on A-ring of flavones and isoflavones, especially at C-5 and C-7, significantly enhanced the inhibitory activities against digestive enzymes and the hydroxylation on positions C-3" and C-4" of B-ring of flavonoids remarkably improved the inhibition.	Flavonoids	221-231	complement C3	Homo sapiens	194-197
22292767-10	2012	The methylation and methoxylation of the hydroxyl group at C-3, C-3" and C-4" of flavonoids decreased or little affected the inhibitory potency against aldose reductases.	Flavonoids	81-91	complement C3	Homo sapiens	59-62
22292767-10	2012	The methylation and methoxylation of the hydroxyl group at C-3, C-3" and C-4" of flavonoids decreased or little affected the inhibitory potency against aldose reductases.	Flavonoids	81-91	complement C3	Homo sapiens	64-67
22292767-12	2012	The methylation and methoxylation of flavonoids obviously affected the inhibitory effect for alpha-glucosidase in vitro depending on the replaced site.	Flavonoids	37-47	sucrase-isomaltase	Homo sapiens	93-110
22751795-3	2012	Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) induced by TNF-alpha in HUVECs.	Flavonoids	0-9	intercellular adhesion molecule 1	Homo sapiens	60-93
22751795-5	2012	The flavonoid extract attenuated TNF-alpha-induced IkappaB phosphorylation as well as NF-kappaB, p65 and p50 translocation from cytosol to nucleus, through inhibition on TNF-alpha- and H(2)O(2)-induced intracellular reactive oxygen species (ROS) production.	Flavonoids	4-13	tumor necrosis factor	Homo sapiens	170-179
22751795-3	2012	Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) induced by TNF-alpha in HUVECs.	Flavonoids	0-9	intercellular adhesion molecule 1	Homo sapiens	95-101
22751795-6	2012	For the anti-angiogenic study, the flavonoid extract inhibited vascular endothelial growth factor (VEGF)-induced cell proliferation and migration in HUVECs, as well as angiogenesis.	Flavonoids	35-44	vascular endothelial growth factor A	Homo sapiens	63-97
22751795-6	2012	For the anti-angiogenic study, the flavonoid extract inhibited vascular endothelial growth factor (VEGF)-induced cell proliferation and migration in HUVECs, as well as angiogenesis.	Flavonoids	35-44	vascular endothelial growth factor A	Homo sapiens	99-103
22751795-3	2012	Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) induced by TNF-alpha in HUVECs.	Flavonoids	0-9	vascular cell adhesion molecule 1	Homo sapiens	140-146
22751795-3	2012	Flavonoid extract was effective in inhibiting expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) induced by TNF-alpha in HUVECs.	Flavonoids	0-9	tumor necrosis factor	Homo sapiens	159-168
22751795-4	2012	The RT-PCR analysis indicated that ICAM-1 mRNA induced by TNF-alpha was inhibited by flavonoid extract.	Flavonoids	85-94	intercellular adhesion molecule 1	Homo sapiens	35-41
22751795-4	2012	The RT-PCR analysis indicated that ICAM-1 mRNA induced by TNF-alpha was inhibited by flavonoid extract.	Flavonoids	85-94	tumor necrosis factor	Homo sapiens	58-67
22751795-5	2012	The flavonoid extract attenuated TNF-alpha-induced IkappaB phosphorylation as well as NF-kappaB, p65 and p50 translocation from cytosol to nucleus, through inhibition on TNF-alpha- and H(2)O(2)-induced intracellular reactive oxygen species (ROS) production.	Flavonoids	4-13	tumor necrosis factor	Homo sapiens	33-42
22751795-5	2012	The flavonoid extract attenuated TNF-alpha-induced IkappaB phosphorylation as well as NF-kappaB, p65 and p50 translocation from cytosol to nucleus, through inhibition on TNF-alpha- and H(2)O(2)-induced intracellular reactive oxygen species (ROS) production.	Flavonoids	4-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	97-100
22751795-5	2012	The flavonoid extract attenuated TNF-alpha-induced IkappaB phosphorylation as well as NF-kappaB, p65 and p50 translocation from cytosol to nucleus, through inhibition on TNF-alpha- and H(2)O(2)-induced intracellular reactive oxygen species (ROS) production.	Flavonoids	4-13	nuclear factor kappa B subunit 1	Homo sapiens	105-108
22634515-0	2012	Flavonoid aglycones can compete with Ochratoxin A for human serum albumin: a new possible mode of action.	Flavonoids	0-9	albumin	Homo sapiens	60-73
22634515-3	2012	However, it is well known that natural flavonoids can also bind to human serum albumin (HSA) at the same binding site as OTA does (site I, subdomain IIA).	Flavonoids	39-49	albumin	Homo sapiens	73-86
22842046-0	2012	Flavonoid interactions with human transthyretin: combined structural and thermodynamic analysis.	Flavonoids	0-9	transthyretin	Homo sapiens	34-47
22956280-8	2012	Genome-wide transcriptome profiling of abs1-1D revealed clear reprogramming of metabolic pathways, and it was demonstrated that BR biosynthesis genes were activated in abs1-1D and that the flavonoid biosynthesis pathway was repressed in abs1-1D, as well as in det2-1.	Flavonoids	189-198	HXXXD-type acyl-transferase family protein	Arabidopsis thaliana	39-43
22304296-4	2012	Using a luciferase reporter gene assay we screened different flavonoids for their ability to induce PON1 in Huh7 hepatocytes in culture.	Flavonoids	61-71	paraoxonase 1	Rattus norvegicus	100-104
22304296-5	2012	Genistein was the most potent flavonoid with regard to its PON1-inducing activity, followed by daidzein, luteolin, isorhamnetin and quercetin.	Flavonoids	30-39	paraoxonase 1	Rattus norvegicus	59-63
22648787-0	2012	In silico and in vivo evaluation of flavonoid extracts on CYP2D6-mediated herb-drug interaction.	Flavonoids	36-45	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	58-64
22648787-2	2012	However, because many flavonoid extracts have been verified to inhibit CYP2D6 the main metabolic enzyme for the majority of antiarrhythmics and beta-blockers, co-administration of flavonoid extracts with these drugs may cause adverse herb-drug interaction in clinic.	Flavonoids	22-31	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	71-77
22648787-2	2012	However, because many flavonoid extracts have been verified to inhibit CYP2D6 the main metabolic enzyme for the majority of antiarrhythmics and beta-blockers, co-administration of flavonoid extracts with these drugs may cause adverse herb-drug interaction in clinic.	Flavonoids	180-189	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	71-77
22648787-3	2012	Here, we evaluated 43 common flavonoids on CYP2D6 inhibition in sillico and four commercial flavonoid extracts in vivo on the pharmacokinetics and pharmacodynamics of metoprolol in rats.	Flavonoids	29-39	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	43-49
22648787-3	2012	Here, we evaluated 43 common flavonoids on CYP2D6 inhibition in sillico and four commercial flavonoid extracts in vivo on the pharmacokinetics and pharmacodynamics of metoprolol in rats.	Flavonoids	29-38	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	43-49
22648787-4	2012	Surprisingly, we found that the core skeletons of flavonoids instead of their substituents determine the extent of inhibiting CYP2D6 by a flavonoid extract.	Flavonoids	50-60	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	126-132
22648787-4	2012	Surprisingly, we found that the core skeletons of flavonoids instead of their substituents determine the extent of inhibiting CYP2D6 by a flavonoid extract.	Flavonoids	50-59	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	126-132
22842046-3	2012	Here we selected and characterized the interaction of flavonoids with the wild type and the V30M amyloidogenic mutant TTR.	Flavonoids	54-64	transthyretin	Homo sapiens	118-121
22842046-4	2012	TTR acid aggregation was evaluated in vitro in the presence of the different flavonoids.	Flavonoids	77-87	transthyretin	Homo sapiens	0-3
22842046-6	2012	Crystal structures of TTRwt in complex with the top binders were also obtained, enabling us to in depth inspect TTR interactions with these flavonoids.	Flavonoids	140-150	transthyretin	Homo sapiens	22-25
22842046-7	2012	The results indicate that changing the number and position of hydroxyl groups attached to the flavonoid core strongly influence flavonoid recognition by TTR, either by changing ligand affinity or its mechanism of interaction with the two sites of TTR.	Flavonoids	94-103	transthyretin	Homo sapiens	153-156
22842046-7	2012	The results indicate that changing the number and position of hydroxyl groups attached to the flavonoid core strongly influence flavonoid recognition by TTR, either by changing ligand affinity or its mechanism of interaction with the two sites of TTR.	Flavonoids	94-103	transthyretin	Homo sapiens	247-250
22842046-7	2012	The results indicate that changing the number and position of hydroxyl groups attached to the flavonoid core strongly influence flavonoid recognition by TTR, either by changing ligand affinity or its mechanism of interaction with the two sites of TTR.	Flavonoids	128-137	transthyretin	Homo sapiens	153-156
22842046-7	2012	The results indicate that changing the number and position of hydroxyl groups attached to the flavonoid core strongly influence flavonoid recognition by TTR, either by changing ligand affinity or its mechanism of interaction with the two sites of TTR.	Flavonoids	128-137	transthyretin	Homo sapiens	247-250
23023684-3	2012	Total flavonoids decreased red blood cell number, hemoglobin, hematocrit, mean corpuscular hemoglobin levels, span of red blood cell electrophoretic mobility, aggregation index of red blood cell, plasma viscosity, whole blood viscosity, and increased deformation index of red blood cell, erythropoietin level in serum.	Flavonoids	6-16	erythropoietin	Rattus norvegicus	288-302
23027370-3	2012	Flavonoids have been shown to sensitize cancer cells to TRAIL-induced apoptosis.	Flavonoids	0-10	TNF superfamily member 10	Homo sapiens	56-61
22885084-1	2012	The experimental induced circular dichroism (ICD) and absorption spectra of the achiral flavonoid kaempferol upon binding to human serum albumin (HSA) were correlated to electronic CD and UV-vis spectra theoretically predicted by time-dependent density functional theory (TDDFT).	Flavonoids	88-97	albumin	Homo sapiens	131-144
22958058-6	2012	Furthermore, glucose consumption, glycogen concentration, and glucokinase activity were significantly elevated, and glucose-6-phosphatase activity was markedly decreased by  Citrus  flavonoids.	Flavonoids	182-192	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	116-137
22996344-10	2012	Strong positive correlations were found between flavonoid, proline and ascorbic acid contents and color intensity with DPPH and FRAP values.	Flavonoids	48-57	mechanistic target of rapamycin kinase	Homo sapiens	128-132
22819449-4	2012	Results of the TF expression showed different behaviors for the two flavonoids studied.	Flavonoids	68-78	coagulation factor III, tissue factor	Homo sapiens	15-17
23156993-3	2012	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-41
23156993-3	2012	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-47
23156993-3	2012	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	progesterone receptor	Homo sapiens	72-93
23156993-3	2012	It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines.	Flavonoids	121-130	tumor protein p53	Homo sapiens	99-102
25400909-5	2012	Flavonoids can also serve as chemical regulators that affect the activity or expression levels of phase II enzymes including UGTs, SULTs and GSTs, and transporters including P-gp, MRP2, BCRP, OATP and OAT.	Flavonoids	0-10	phosphoglycolate phosphatase	Homo sapiens	174-178
25400909-5	2012	Flavonoids can also serve as chemical regulators that affect the activity or expression levels of phase II enzymes including UGTs, SULTs and GSTs, and transporters including P-gp, MRP2, BCRP, OATP and OAT.	Flavonoids	0-10	ATP binding cassette subfamily C member 2	Homo sapiens	180-184
25400909-5	2012	Flavonoids can also serve as chemical regulators that affect the activity or expression levels of phase II enzymes including UGTs, SULTs and GSTs, and transporters including P-gp, MRP2, BCRP, OATP and OAT.	Flavonoids	0-10	BCR pseudogene 1	Homo sapiens	186-190
25400909-5	2012	Flavonoids can also serve as chemical regulators that affect the activity or expression levels of phase II enzymes including UGTs, SULTs and GSTs, and transporters including P-gp, MRP2, BCRP, OATP and OAT.	Flavonoids	0-10	solute carrier organic anion transporter family member 1A2	Homo sapiens	192-196
25400909-8	2012	This review article focused on the disposition of flavonoids and effects of flavonoids on relevant enzymes (e.g. UGTs and SULTs) and transporters (e.g. MRP2 and BCRP) involved in the interplay between phase II enzymes and efflux transporters.	Flavonoids	50-60	ATP binding cassette subfamily C member 2	Homo sapiens	152-156
25400909-8	2012	This review article focused on the disposition of flavonoids and effects of flavonoids on relevant enzymes (e.g. UGTs and SULTs) and transporters (e.g. MRP2 and BCRP) involved in the interplay between phase II enzymes and efflux transporters.	Flavonoids	50-60	BCR pseudogene 1	Homo sapiens	161-165
25400909-8	2012	This review article focused on the disposition of flavonoids and effects of flavonoids on relevant enzymes (e.g. UGTs and SULTs) and transporters (e.g. MRP2 and BCRP) involved in the interplay between phase II enzymes and efflux transporters.	Flavonoids	76-86	ATP binding cassette subfamily C member 2	Homo sapiens	152-156
25400909-8	2012	This review article focused on the disposition of flavonoids and effects of flavonoids on relevant enzymes (e.g. UGTs and SULTs) and transporters (e.g. MRP2 and BCRP) involved in the interplay between phase II enzymes and efflux transporters.	Flavonoids	76-86	BCR pseudogene 1	Homo sapiens	161-165
25400909-9	2012	The effects of flavonoids on other metabolic enzymes (e.g. GSTs) or transporters (e.g. P-gp, OATP and OAT) are also addressed but that is not the emphasis of this review.	Flavonoids	15-25	phosphoglycolate phosphatase	Homo sapiens	87-91
25400909-9	2012	The effects of flavonoids on other metabolic enzymes (e.g. GSTs) or transporters (e.g. P-gp, OATP and OAT) are also addressed but that is not the emphasis of this review.	Flavonoids	15-25	solute carrier organic anion transporter family member 1A2	Homo sapiens	93-97
23023684-6	2012	Changes in hemodynamic, hematologic parameters, and erythropoietin content suggest that administration of total flavonoids from seabuckthorn may be useful in the prevention of high altitude polycythaemia in rats.	Flavonoids	112-122	erythropoietin	Rattus norvegicus	52-66
22794923-7	2012	Chalcone synthase (CHS) and chalcone isomerase (CHI) genes are involved in the flavonoid biosynthetic pathway and their expression is systemically induced by UV-B in a NO dependent pathway.	Flavonoids	79-88	chalcone synthase	Zea mays	0-17
22958586-0	2012	Red wine and component flavonoids inhibit UGT2B17 in vitro.	Flavonoids	23-33	UDP glucuronosyltransferase family 2 member B17	Homo sapiens	42-49
22743247-10	2012	Taken together the data suggests that the dietary flavonoid nobiletin induces its own metabolism and in turn enhances its cytostatic effect in MCF7 breast adenocarcinoma cells, via CYP1A1 and CYP1B1 upregulation.	Flavonoids	50-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	181-187
22743247-10	2012	Taken together the data suggests that the dietary flavonoid nobiletin induces its own metabolism and in turn enhances its cytostatic effect in MCF7 breast adenocarcinoma cells, via CYP1A1 and CYP1B1 upregulation.	Flavonoids	50-59	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	192-198
22324650-3	2012	Here, the flavonoid pathway was engineered by silencing a gene encoding flavonol synthase (FLS) in tobacco to direct the flow of metabolites towards production of flavan-3-ols.	Flavonoids	10-19	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	72-89
22324650-3	2012	Here, the flavonoid pathway was engineered by silencing a gene encoding flavonol synthase (FLS) in tobacco to direct the flow of metabolites towards production of flavan-3-ols.	Flavonoids	10-19	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	91-94
22324650-5	2012	The silenced lines showed a significant increase in expression of genes for dihydroflavonol reductase and anthocyanidin synthase, a downstream gene towards epicatechin production, with no significant change in expression of other genes of the flavonoid pathway.	Flavonoids	243-252	leucoanthocyanidin dioxygenase-like	Nicotiana tabacum	106-128
22471974-3	2012	Flavocoxid is a novel flavonoid-based "dual inhibitor" of the COX and 5-LOX enzymes.	Flavonoids	22-31	lysyl oxidase	Homo sapiens	72-75
21452393-5	2012	Moreover, alpha-naphthoflavone, a flavonoid antagonist of AhR, was also able to induce [Ca(2+)](i).	Flavonoids	34-43	aryl hydrocarbon receptor	Homo sapiens	58-61
22743247-0	2012	Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.	Flavonoids	28-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-55
22743247-1	2012	Recent studies have demonstrated cytochrome P450 CYP1-mediated metabolism and CYP1-enzyme induction by naturally occurring flavonoids in cancer cell line models.	Flavonoids	123-133	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	78-82
22610270-2	2012	Nicotiana tabacum malonyltransferase 1 (NtMaT1) is a member of anthocyanin acyltransferase subfamily that uses malonyl-CoA (MLC) as donor catalyzing transacylation in a range of flavonoid and naphthol glucosides.	Flavonoids	178-187	phenolic glucoside malonyltransferase 1	Nicotiana tabacum	40-46
22794923-7	2012	Chalcone synthase (CHS) and chalcone isomerase (CHI) genes are involved in the flavonoid biosynthetic pathway and their expression is systemically induced by UV-B in a NO dependent pathway.	Flavonoids	79-88	chalcone isomerase	Zea mays	28-46
22794923-7	2012	Chalcone synthase (CHS) and chalcone isomerase (CHI) genes are involved in the flavonoid biosynthetic pathway and their expression is systemically induced by UV-B in a NO dependent pathway.	Flavonoids	79-88	chalcone isomerase	Zea mays	48-51
22634221-0	2012	Total Flavonoids of Fructus Chorspondiatis inhibits collagen synthesis of cultured rat cardiac fibroblasts induced by angiotensin II: correlated with NO/cGMP signaling pathway.	Flavonoids	6-16	angiotensinogen	Rattus norvegicus	118-132
23158493-0	2012	[Involvement of Wnt/beta-catenin signaling in the osteogenesis of bone marrow mesenchymal stem cells induced by drynaria total flavonoids].	Flavonoids	127-137	Wnt family member 2	Rattus norvegicus	16-19
23158493-0	2012	[Involvement of Wnt/beta-catenin signaling in the osteogenesis of bone marrow mesenchymal stem cells induced by drynaria total flavonoids].	Flavonoids	127-137	catenin beta 1	Rattus norvegicus	20-32
23158493-1	2012	OBJECTIVE: To explore the effects of the expression of Wnt/beta-catenin signaling factor mRNA during drynaria total flavonoids on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Flavonoids	116-126	Wnt family member 2	Rattus norvegicus	55-58
23158493-1	2012	OBJECTIVE: To explore the effects of the expression of Wnt/beta-catenin signaling factor mRNA during drynaria total flavonoids on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Flavonoids	116-126	catenin beta 1	Rattus norvegicus	59-71
23158493-8	2012	At Day 14, the expression of beta-catenin mRNA was higher in the drynaria total flavonoids group higher than that in the blank control group (0.357 +- 0.063 vs 0.174 +- 0.013, P &lt; 0.05).	Flavonoids	80-90	catenin beta 1	Rattus norvegicus	29-41
23158493-9	2012	At Day 7, the expressions of LEF-1 and cycline D mRNA were higher in the drynaria total flavonoids group than those in the blank control group (LEF-1 0.0611 +- 0.0002 vs 0.0345 +- 0.0131; cycline D 0.1510 +- 0.0255 vs 0.0718 +- 0.0294, all P &lt; 0.05).	Flavonoids	88-98	lymphoid enhancer binding factor 1	Rattus norvegicus	29-34
23158493-9	2012	At Day 7, the expressions of LEF-1 and cycline D mRNA were higher in the drynaria total flavonoids group than those in the blank control group (LEF-1 0.0611 +- 0.0002 vs 0.0345 +- 0.0131; cycline D 0.1510 +- 0.0255 vs 0.0718 +- 0.0294, all P &lt; 0.05).	Flavonoids	88-98	lymphoid enhancer binding factor 1	Rattus norvegicus	144-149
22957419-10	2012	LSE had significant higher total phenol (300.11 +/- 1.99), flavonoid (53.12 +/- 0.48) and tannin content (118.90 +/- 0.15) compared to ASE which possessed total phenol (159.93 +/- 0.87); flavonoid (9.37 +/- 0.73) and tannin content (80.5 +/- 0.19).	Flavonoids	59-68	low set ears	Mus musculus	0-3
22794353-0	2012	Inhibition of protein kinase CK2 by flavonoids and tyrphostins.	Flavonoids	36-46	Calcium-dependent protein kinase 6	Zea mays	29-32
22762350-4	2012	Using atomistic, explicit-solvent molecular dynamics simulations, we have investigated the association of the flavonoid morin with Abeta monomers and dimers.	Flavonoids	110-119	amyloid beta precursor protein	Homo sapiens	131-136
22702966-2	2012	The principal intent of this work is to check binding domain and structural changes of human serum albumin (HSA), the primary carrier of flavonoids, in blood plasma association with hesperidin by employing molecular modeling, steady state and time-resolved fluorescence, and circular dichroism (CD) methods.	Flavonoids	137-147	albumin	Homo sapiens	93-106
22703874-2	2012	Both atorvastatin calcium (lipitor) as well as flavonoid rich fruit such as tart cherry demonstrate potent anti-inflammatory effects on IL-6 secretion.	Flavonoids	47-56	interleukin 6	Homo sapiens	136-140
22766803-4	2012	Natural compounds such as silibinin and cyanidin-3-rutinoside and other flavonoids showed the highest theoretical affinities for iNOS.	Flavonoids	72-82	nitric oxide synthase 2	Homo sapiens	129-133
22758640-3	2012	We summarize evidence linking flavonoid consumption with the risk factors defining MS: obesity, hypertriglyceridemia, hypercholesterolemia, hypertension, and insulin resistance.	Flavonoids	30-39	insulin	Homo sapiens	158-165
22758641-2	2012	We recently demonstrated that the flavonoid quercetin, naturally present in the diet and belonging to the class of phytochemicals, is able to sensitize several leukemia cell lines and B cells isolated from patients affected by chronic lymphocytic leukemia (B-CLL), in addition to apoptotic inducers (anti-CD95 and rTRAIL).	Flavonoids	34-43	Fas cell surface death receptor	Homo sapiens	305-309
22758641-2	2012	We recently demonstrated that the flavonoid quercetin, naturally present in the diet and belonging to the class of phytochemicals, is able to sensitize several leukemia cell lines and B cells isolated from patients affected by chronic lymphocytic leukemia (B-CLL), in addition to apoptotic inducers (anti-CD95 and rTRAIL).	Flavonoids	34-43	TNF superfamily member 10	Rattus norvegicus	314-320
22348918-9	2012	This glucuronated flavonoid is a promising template for rational designing of anticancer drugs to be used in the treatment of pathological states involving the unregulated activity of plasmin.	Flavonoids	18-27	plasminogen	Homo sapiens	184-191
22449725-0	2012	The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells.	Flavonoids	12-21	aurora kinase B	Homo sapiens	40-48
22449725-4	2012	Here we report that the dietary flavonoid luteolin could inhibit recombinant Aurora B in radiometric activity assay (IC(50)=0.357 muM) and bind to Aurora B with a high affinity (K(D)=5.85 muM) measured by Biacore 3000.	Flavonoids	32-41	aurora kinase B	Homo sapiens	77-85
22449725-4	2012	Here we report that the dietary flavonoid luteolin could inhibit recombinant Aurora B in radiometric activity assay (IC(50)=0.357 muM) and bind to Aurora B with a high affinity (K(D)=5.85 muM) measured by Biacore 3000.	Flavonoids	32-41	aurora kinase B	Homo sapiens	147-155
22564824-5	2012	Studies in mice and human subjects indicate that the apoE epsilon3 but not the apoE epsilon4 genotype may significantly benefit from dietary flavonoids (e.g. quercetin) and n-3 fatty acids.	Flavonoids	141-151	apolipoprotein E	Homo sapiens	53-57
22564824-8	2012	The present review aims at evaluation of current data available on interactions between apoE polymorphism and dietary responsiveness to flavonoids, fat soluble vitamins and n-3 fatty acids.	Flavonoids	136-146	apolipoprotein E	Homo sapiens	88-92
22083247-5	2012	The upregulations of anthocyanin isogenes (DFR1 and GST26) and the anthocyanin/flavonol-3-O-glycosyltransferase (UGT78K2) were identified by quantitative RT-PCR to be endogenous feedback and feedforward responses to overaccumulation of upstream flavonoid intermediates resulting from ANR1 and ANR2 suppressions.	Flavonoids	245-254	vestitone reductase	Glycine max	43-47
22083247-5	2012	The upregulations of anthocyanin isogenes (DFR1 and GST26) and the anthocyanin/flavonol-3-O-glycosyltransferase (UGT78K2) were identified by quantitative RT-PCR to be endogenous feedback and feedforward responses to overaccumulation of upstream flavonoid intermediates resulting from ANR1 and ANR2 suppressions.	Flavonoids	245-254	UDP-glucose:flavonoid 3-O-glucosyltransferase	Glycine max	113-120
22083247-5	2012	The upregulations of anthocyanin isogenes (DFR1 and GST26) and the anthocyanin/flavonol-3-O-glycosyltransferase (UGT78K2) were identified by quantitative RT-PCR to be endogenous feedback and feedforward responses to overaccumulation of upstream flavonoid intermediates resulting from ANR1 and ANR2 suppressions.	Flavonoids	245-254	anthocyanidin reductase 1	Glycine max	284-288
22348918-7	2012	Most interestingly, cell-based assays showed that this flavonoid was effective in suppressing plasmin-induced loss of cancer cell adhesion.	Flavonoids	55-64	plasminogen	Homo sapiens	94-101
22957419-10	2012	LSE had significant higher total phenol (300.11 +/- 1.99), flavonoid (53.12 +/- 0.48) and tannin content (118.90 +/- 0.15) compared to ASE which possessed total phenol (159.93 +/- 0.87); flavonoid (9.37 +/- 0.73) and tannin content (80.5 +/- 0.19).	Flavonoids	187-196	low set ears	Mus musculus	0-3
22957419-20	2012	The possible synergistic therapeutic effects may be due the presence of the antioxidant rich flavonoids, phenols and tannins present in LSE and ASE.	Flavonoids	93-103	low set ears	Mus musculus	136-139
22521613-3	2012	In the present study, we investigated the effects of isoliquiritigenin (ISL), a natural flavonoid isolated from licorice, on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced in vitro osteoclastogenesis and inflammation-mediated bone destruction in vivo.	Flavonoids	88-97	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	177-182
22689471-2	2012	Many FV and their juices contain flavonoids, some of which increase endothelial nitric oxide synthase (eNOS) activity.	Flavonoids	33-43	nitric oxide synthase 3	Homo sapiens	68-101
22552784-0	2012	The flavonoid resveratrol suppresses growth of human malignant pleural             mesothelioma cells through direct inhibition of specificity protein 1.	Flavonoids	4-13	Sp1 transcription factor	Homo sapiens	131-152
22689471-2	2012	Many FV and their juices contain flavonoids, some of which increase endothelial nitric oxide synthase (eNOS) activity.	Flavonoids	33-43	nitric oxide synthase 3	Homo sapiens	103-107
22437427-3	2012	In order to contribute to these efforts, four synthetic flavonoid derivatives FL1-FL4 were rationally selected according to the principles of bifunctionality and their abilities to chelate metal ions, interact with Abeta, inhibit metal-induced Abeta aggregation, scavenge radicals, and regulate the formation of reactive oxygen species (ROS) were studied using physical methods and biological assays.	Flavonoids	56-65	FL1	Homo sapiens	78-81
22700507-8	2012	To assess the specificity of Hsp90, we evaluated the efficacy of the flavonoid quercetin, an inhibitor of Hsp70 synthesis, in preventing TD development; it decreased Hsp70 levels but not those of Hsp90 in the control growth plates and prevented upregulation of Hsp70 in the TD-affected growth plates.	Flavonoids	69-78	heat shock protein family A (Hsp70) member 4	Homo sapiens	166-171
22700507-8	2012	To assess the specificity of Hsp90, we evaluated the efficacy of the flavonoid quercetin, an inhibitor of Hsp70 synthesis, in preventing TD development; it decreased Hsp70 levels but not those of Hsp90 in the control growth plates and prevented upregulation of Hsp70 in the TD-affected growth plates.	Flavonoids	69-78	heat shock protein family A (Hsp70) member 4	Homo sapiens	166-171
22437427-10	2012	Overall, the studies here suggest that although four flavonoid molecules were selected based on expected bifunctionality, their properties and metal-Abeta reactivity were varied depending on the structure differences, demonstrating that bifunctionality must be well tuned to afford desirable reactivity.	Flavonoids	53-62	amyloid beta precursor protein	Homo sapiens	149-154
22552501-4	2012	We also observed             that downregulation of the phosphorylation of retinoblastoma protein (pRB) by             this flavonoid was associated with enhanced binding of pRB and the transcription             factor E2F-1.	Flavonoids	124-133	RB transcriptional corepressor 1	Homo sapiens	99-102
22552501-4	2012	We also observed             that downregulation of the phosphorylation of retinoblastoma protein (pRB) by             this flavonoid was associated with enhanced binding of pRB and the transcription             factor E2F-1.	Flavonoids	124-133	RB transcriptional corepressor 1	Homo sapiens	174-177
22552501-4	2012	We also observed             that downregulation of the phosphorylation of retinoblastoma protein (pRB) by             this flavonoid was associated with enhanced binding of pRB and the transcription             factor E2F-1.	Flavonoids	124-133	E2F transcription factor 1	Homo sapiens	219-224
22437427-3	2012	In order to contribute to these efforts, four synthetic flavonoid derivatives FL1-FL4 were rationally selected according to the principles of bifunctionality and their abilities to chelate metal ions, interact with Abeta, inhibit metal-induced Abeta aggregation, scavenge radicals, and regulate the formation of reactive oxygen species (ROS) were studied using physical methods and biological assays.	Flavonoids	56-65	amyloid beta precursor protein	Homo sapiens	215-220
22465834-4	2012	In addition, these flavonoids significantly maintained antioxidative defense systems preserving the activities of superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GSH-Px) and the content of glutathione (GSH) decreased by glutamate insult.	Flavonoids	19-29	glutathione reductase	Mus musculus	142-163
22525859-7	2012	These results indicated that C. maackii whole plants and its flavonoids inhibit the expression of iNOS and COX-2 in through the inhibition of ROS generation, and therefore can be considered as a useful therapeutic and preventive approach for the treatment of various inflammatory and oxidative stress-related diseases.	Flavonoids	61-71	nitric oxide synthase 2, inducible	Mus musculus	98-102
22465834-4	2012	In addition, these flavonoids significantly maintained antioxidative defense systems preserving the activities of superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GSH-Px) and the content of glutathione (GSH) decreased by glutamate insult.	Flavonoids	19-29	glutathione reductase	Mus musculus	165-167
22525859-7	2012	These results indicated that C. maackii whole plants and its flavonoids inhibit the expression of iNOS and COX-2 in through the inhibition of ROS generation, and therefore can be considered as a useful therapeutic and preventive approach for the treatment of various inflammatory and oxidative stress-related diseases.	Flavonoids	61-71	prostaglandin-endoperoxide synthase 2	Mus musculus	107-112
22442426-7	2012	Three genes, namely TRANSPARENT TESTA (TT)7, TT15, and MYB12, were proposed to underlie their variations since the corresponding mutants and QTLs displayed similar specific flavonoid changes.	Flavonoids	173-182	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	45-49
22419743-0	2012	Mutation of Arabidopsis HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.	Flavonoids	85-94	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	24-27
22419743-6	2012	However, the HY1 mutant exhibited UV-C hypersensitivity, consistent with the observed decreases in chlorophyll content, and carotenoid and flavonoid metabolism, as well as the down-regulation of antioxidant defences, thereby resulting in severe oxidative damage.	Flavonoids	139-148	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	13-16
22652788-2	2012	Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells.	Flavonoids	26-36	FAM20C golgi associated secretory pathway kinase	Homo sapiens	161-164
22652788-2	2012	Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells.	Flavonoids	26-36	nitric oxide synthase 2	Homo sapiens	289-320
22652788-2	2012	Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells.	Flavonoids	26-36	nitric oxide synthase 2	Homo sapiens	322-326
22665395-0	2012	Comparative analysis of Rac1 binding efficiency with different classes of ligands: morpholines, flavonoids and imidazoles.	Flavonoids	96-106	Rac family small GTPase 1	Homo sapiens	24-28
22665395-8	2012	We have applied this integrative chemo-bioinformatics workflow to a comparative analysis of three different classes of ligands (morpholines, flavonoids and imidazoles) against the Rac1 protein.	Flavonoids	141-151	Rac family small GTPase 1	Homo sapiens	180-184
22419743-8	2012	Transcription factors involved in the synthesis of flavonoid or UV responses were induced by UV-C, but reduced in the hy1 mutant.	Flavonoids	51-60	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	118-121
22419743-9	2012	Overall, the findings showed that mutation of HY1 triggered UV-C hypersensitivity, by impairing carotenoid and flavonoid synthesis and antioxidant defences.	Flavonoids	111-120	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	46-49
22442426-7	2012	Three genes, namely TRANSPARENT TESTA (TT)7, TT15, and MYB12, were proposed to underlie their variations since the corresponding mutants and QTLs displayed similar specific flavonoid changes.	Flavonoids	173-182	myb domain protein 12	Arabidopsis thaliana	55-60
22542668-7	2012	Analysis of structure-activity data revealed that flavonoids containing two hydroxyl groups in ring B and a carbonyl group at C-4 in combination with a double bond between C-2 and C-3 produced a much stronger inhibition, whereas substitution of a hydroxyl group at C-3 was associated with a less inhibitory effect.	Flavonoids	50-60	complement C4A (Rodgers blood group)	Homo sapiens	126-129
22573369-6	2012	Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation.	Flavonoids	17-27	interleukin 6	Homo sapiens	122-126
22573369-6	2012	Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation.	Flavonoids	17-27	signal transducer and activator of transcription 3	Homo sapiens	135-140
22542668-7	2012	Analysis of structure-activity data revealed that flavonoids containing two hydroxyl groups in ring B and a carbonyl group at C-4 in combination with a double bond between C-2 and C-3 produced a much stronger inhibition, whereas substitution of a hydroxyl group at C-3 was associated with a less inhibitory effect.	Flavonoids	50-60	complement C2	Homo sapiens	172-183
22542668-7	2012	Analysis of structure-activity data revealed that flavonoids containing two hydroxyl groups in ring B and a carbonyl group at C-4 in combination with a double bond between C-2 and C-3 produced a much stronger inhibition, whereas substitution of a hydroxyl group at C-3 was associated with a less inhibitory effect.	Flavonoids	50-60	complement C3	Homo sapiens	180-183
22543015-4	2012	In the present study, we predicted the 3D structure of AR in rat and human using a docking algorithm to simulate binding between AR and prenylated flavonoids (1 and 2) and kaempferol (3) and scrutinized the reversible inhibition of AR by these ARIs.	Flavonoids	147-157	aldo-keto reductase family 1 member B	Homo sapiens	55-57
22616882-18	2012	CONCLUSION: These findings indicate that 3,6-DHF is a potent natural chemopreventive agent, and that miR-34a and miR-21 play roles in MNU-induced breast carcinogenesis and the anticancer mechanism of flavonoids.	Flavonoids	200-210	microRNA 34a	Rattus norvegicus	101-108
22475000-3	2012	The flavonoids and gallates had variable effects on peroxidase activity, but all dropped lignification pH.	Flavonoids	4-14	peroxidase 1	Zea mays	52-62
22616882-18	2012	CONCLUSION: These findings indicate that 3,6-DHF is a potent natural chemopreventive agent, and that miR-34a and miR-21 play roles in MNU-induced breast carcinogenesis and the anticancer mechanism of flavonoids.	Flavonoids	200-210	microRNA 21	Rattus norvegicus	113-119
22394605-5	2012	The G. biloba flavonoids showed a competitive inhibition of the OATP1B1- and OATP1B3-mediated [3H]BSP and the OATP1B1-mediated [3H]atorvastatin uptake.	Flavonoids	14-24	solute carrier organic anion transporter family member 1B1	Homo sapiens	64-71
22394605-5	2012	The G. biloba flavonoids showed a competitive inhibition of the OATP1B1- and OATP1B3-mediated [3H]BSP and the OATP1B1-mediated [3H]atorvastatin uptake.	Flavonoids	14-24	solute carrier organic anion transporter family member 1B3	Homo sapiens	77-84
22394605-5	2012	The G. biloba flavonoids showed a competitive inhibition of the OATP1B1- and OATP1B3-mediated [3H]BSP and the OATP1B1-mediated [3H]atorvastatin uptake.	Flavonoids	14-24	solute carrier organic anion transporter family member 1B1	Homo sapiens	110-117
22394605-8	2012	Among the grapefruit flavonoids, naringenin was the most potent inhibitor of the OATP1B1- and OATP1B3-mediated [3H]BSP transport with IC(50)-values of 81.6+-1.1muM and 101.1+-1.1muM, respectively.	Flavonoids	21-31	solute carrier organic anion transporter family member 1B1	Homo sapiens	81-88
22394605-8	2012	Among the grapefruit flavonoids, naringenin was the most potent inhibitor of the OATP1B1- and OATP1B3-mediated [3H]BSP transport with IC(50)-values of 81.6+-1.1muM and 101.1+-1.1muM, respectively.	Flavonoids	21-31	solute carrier organic anion transporter family member 1B3	Homo sapiens	94-101
22394605-10	2012	Taken together, these in vitro studies showed that the investigated flavonoids inhibit the OATP1B1- and OATP1B3-mediated drug transport, which could be a mechanism for food-drug interactions in humans.	Flavonoids	68-78	solute carrier organic anion transporter family member 1B1	Homo sapiens	91-98
22394605-10	2012	Taken together, these in vitro studies showed that the investigated flavonoids inhibit the OATP1B1- and OATP1B3-mediated drug transport, which could be a mechanism for food-drug interactions in humans.	Flavonoids	68-78	solute carrier organic anion transporter family member 1B3	Homo sapiens	104-111
22350287-4	2012	The IC(50) of six flavonoid compounds were 47-381 muM.	Flavonoids	18-27	latexin	Homo sapiens	50-53
22241506-0	2012	The influence of the total flavonoids of Hedysarum polybotry on the proliferation, cell cycle, and expressions of p21Ras and proliferating cell nuclear antigen gene in erythroleukemia cell line K562.	Flavonoids	27-37	HRas proto-oncogene, GTPase	Homo sapiens	114-120
22246135-6	2012	Our results demonstrated that flavonoid baicalein protected against H(2)O(2)-induced cell death by inhibition of JNK/ERK pathways activation and other key molecules in apoptotic pathways, including blockage of Bax and caspase-9 activation, induction of Bcl-2 expression and prevention of cell death.	Flavonoids	30-39	mitogen-activated protein kinase 8	Homo sapiens	113-116
22246135-6	2012	Our results demonstrated that flavonoid baicalein protected against H(2)O(2)-induced cell death by inhibition of JNK/ERK pathways activation and other key molecules in apoptotic pathways, including blockage of Bax and caspase-9 activation, induction of Bcl-2 expression and prevention of cell death.	Flavonoids	30-39	mitogen-activated protein kinase 1	Homo sapiens	117-120
22246135-6	2012	Our results demonstrated that flavonoid baicalein protected against H(2)O(2)-induced cell death by inhibition of JNK/ERK pathways activation and other key molecules in apoptotic pathways, including blockage of Bax and caspase-9 activation, induction of Bcl-2 expression and prevention of cell death.	Flavonoids	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	210-213
22246135-6	2012	Our results demonstrated that flavonoid baicalein protected against H(2)O(2)-induced cell death by inhibition of JNK/ERK pathways activation and other key molecules in apoptotic pathways, including blockage of Bax and caspase-9 activation, induction of Bcl-2 expression and prevention of cell death.	Flavonoids	30-39	caspase 9	Homo sapiens	218-227
22246135-6	2012	Our results demonstrated that flavonoid baicalein protected against H(2)O(2)-induced cell death by inhibition of JNK/ERK pathways activation and other key molecules in apoptotic pathways, including blockage of Bax and caspase-9 activation, induction of Bcl-2 expression and prevention of cell death.	Flavonoids	30-39	BCL2 apoptosis regulator	Homo sapiens	253-258
22241506-1	2012	OBJECTIVE: To investigate the effect of total flavonoids of Hedysarum polybotry on the proliferation, cell cycle, and expressions of p21(Ras) and proliferating cell nuclear antigen (PCNA) gene in erythroleukemia cell line K562.	Flavonoids	46-56	H3 histone pseudogene 16	Homo sapiens	133-136
22241506-1	2012	OBJECTIVE: To investigate the effect of total flavonoids of Hedysarum polybotry on the proliferation, cell cycle, and expressions of p21(Ras) and proliferating cell nuclear antigen (PCNA) gene in erythroleukemia cell line K562.	Flavonoids	46-56	proliferating cell nuclear antigen	Homo sapiens	146-180
22241506-1	2012	OBJECTIVE: To investigate the effect of total flavonoids of Hedysarum polybotry on the proliferation, cell cycle, and expressions of p21(Ras) and proliferating cell nuclear antigen (PCNA) gene in erythroleukemia cell line K562.	Flavonoids	46-56	proliferating cell nuclear antigen	Homo sapiens	182-186
22241506-5	2012	The immunocytochemistry method was applied to quantitatively analyze the effects of flavonoids of Hedysarum polybotry on changes p21(Ras) and PCNA gene expressions.	Flavonoids	84-94	H3 histone pseudogene 16	Homo sapiens	129-132
22241506-5	2012	The immunocytochemistry method was applied to quantitatively analyze the effects of flavonoids of Hedysarum polybotry on changes p21(Ras) and PCNA gene expressions.	Flavonoids	84-94	proliferating cell nuclear antigen	Homo sapiens	142-146
22241506-8	2012	Compared with the control group, p21(Ras) and PCNA gene expressions were decreased significantly in K562 cells treated with total flavonoids of Hedysarum polybotry (40 and 80 mug/mL, respectively) for 48 h. CONCLUSION: The inhibitory effect on proliferation of K562 cells was observed in the groups treated with flavonoids of Hedysarum polybotry, which might be related to cells arresting.	Flavonoids	130-140	H3 histone pseudogene 16	Homo sapiens	33-36
22241506-8	2012	Compared with the control group, p21(Ras) and PCNA gene expressions were decreased significantly in K562 cells treated with total flavonoids of Hedysarum polybotry (40 and 80 mug/mL, respectively) for 48 h. CONCLUSION: The inhibitory effect on proliferation of K562 cells was observed in the groups treated with flavonoids of Hedysarum polybotry, which might be related to cells arresting.	Flavonoids	130-140	proliferating cell nuclear antigen	Homo sapiens	46-50
22241506-8	2012	Compared with the control group, p21(Ras) and PCNA gene expressions were decreased significantly in K562 cells treated with total flavonoids of Hedysarum polybotry (40 and 80 mug/mL, respectively) for 48 h. CONCLUSION: The inhibitory effect on proliferation of K562 cells was observed in the groups treated with flavonoids of Hedysarum polybotry, which might be related to cells arresting.	Flavonoids	312-322	H3 histone pseudogene 16	Homo sapiens	33-36
22241506-8	2012	Compared with the control group, p21(Ras) and PCNA gene expressions were decreased significantly in K562 cells treated with total flavonoids of Hedysarum polybotry (40 and 80 mug/mL, respectively) for 48 h. CONCLUSION: The inhibitory effect on proliferation of K562 cells was observed in the groups treated with flavonoids of Hedysarum polybotry, which might be related to cells arresting.	Flavonoids	312-322	proliferating cell nuclear antigen	Homo sapiens	46-50
26434259-9	2012	Results of the currents study suggest that among the citrus flavonoids, double bond between C2 and C3 and hydroxyl group at C3, C6 are highly decisive for the proliferation inhibition and apoptosis induction ability.	Flavonoids	60-70	complement C2	Homo sapiens	92-101
22295890-6	2012	These findings demonstrated that low concentrations of singly non-effective flavonoids when are combined exert a synergistic effect in inhibiting AngII-induced redox-sensitive signalling pathways.	Flavonoids	76-86	angiotensinogen	Rattus norvegicus	146-151
22213816-3	2012	Depending on their structure, flavonoids have been shown to stimulate or inhibit rhizobial nod gene expression, cause chemoattraction of rhizobia towards the root, inhibit root pathogens, stimulate mycorrhizal spore germination and hyphal branching, mediate allelopathic interactions between plants, affect quorum sensing, and chelate soil nutrients.	Flavonoids	30-40	atrophin 1	Homo sapiens	91-94
22057676-4	2012	We report here, for the first time, that Scutellaria ocmulgee leaf extract (SocL) and flavonoid wogonin could inhibit TGF-beta1-induced T(reg) activity in malignant gliomas.	Flavonoids	86-95	transforming growth factor, beta 1	Rattus norvegicus	118-127
22307090-0	2012	In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8).	Flavonoids	31-41	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	51-70
22307090-2	2012	CYP2C8 was co-expressed with NADPH-cytochrome P450 reductase in Escherichia coli and used to characterise potency and mechanism of these flavonoids on the isoform.	Flavonoids	137-147	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	0-6
22307090-4	2012	Our results indicated that the flavonoids inhibited CYP2C8 with different potency.	Flavonoids	31-41	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	52-58
21554013-2	2012	In this work, flavonoids were studied for the affinities for human serum albumin (HSA) in the presence and absence of CdTe G-QDs by fluorescence quenching method.	Flavonoids	14-24	albumin	Homo sapiens	67-80
22307090-0	2012	In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8).	Flavonoids	31-41	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	72-78
22151247-3	2012	We have previously shown the MYB305 regulates the expression of flavonoid metabolic genes as well as of nectar proteins (nectarins); however, the myb305 plants showed other floral phenotypes that we investigate in these studies.	Flavonoids	64-73	myb-related protein 305-like	Nicotiana tabacum	29-35
22447155-6	2012	UV-B radiation, acting through UVR8, increased the levels of flavonoids and sinapates in leaf tissue.	Flavonoids	61-71	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	31-35
22350517-0	2012	Rotenone-induced death of RGC-5 cells is caspase independent, involves the JNK and p38 pathways and is attenuated by specific green tea flavonoids.	Flavonoids	136-146	mitogen-activated protein kinase 8	Mus musculus	75-78
22350517-0	2012	Rotenone-induced death of RGC-5 cells is caspase independent, involves the JNK and p38 pathways and is attenuated by specific green tea flavonoids.	Flavonoids	136-146	mitogen-activated protein kinase 14	Mus musculus	83-86
22151247-3	2012	We have previously shown the MYB305 regulates the expression of flavonoid metabolic genes as well as of nectar proteins (nectarins); however, the myb305 plants showed other floral phenotypes that we investigate in these studies.	Flavonoids	64-73	myb-related protein 305-like	Nicotiana tabacum	146-152
22151247-9	2012	In addition to regulating nectarin and flavonoid metabolic gene expression, these results suggest that MYB305 may also function in the tobacco nectary maturation program by controlling the expression of starch metabolic genes.	Flavonoids	39-48	myb-related protein 305-like	Nicotiana tabacum	103-109
22140296-0	2012	Some natural flavonoids are competitive inhibitors of Caspase-1, -3 and -7 despite their cellular toxicity.	Flavonoids	13-23	caspase 1	Homo sapiens	54-74
22429094-5	2012	It was found that a citrus flavonoid, hesperetin (1), increased ABCA1 promoter and LXR enhancer activities in THP-1 macrophages.	Flavonoids	27-36	ATP binding cassette subfamily A member 1	Homo sapiens	64-69
22429094-5	2012	It was found that a citrus flavonoid, hesperetin (1), increased ABCA1 promoter and LXR enhancer activities in THP-1 macrophages.	Flavonoids	27-36	GLI family zinc finger 2	Homo sapiens	110-115
22429094-6	2012	It was also found that this flavonoid promoted PPAR-enhancing activity.	Flavonoids	28-37	peroxisome proliferator activated receptor alpha	Homo sapiens	47-51
22140296-3	2012	It has been discovered that several flavonoids are inhibitors of caspases.	Flavonoids	36-46	caspase 1	Homo sapiens	65-73
22266210-0	2012	III-10, a newly synthesized flavonoid, induced differentiation of human U937 leukemia cells via PKCdelta activation.	Flavonoids	28-37	protein kinase C delta	Homo sapiens	96-104
22202969-1	2012	Addition of the flavonoid quercetin to cultivations of the alpha(1)-antitrypsin (A1AT) producing human AGE1.HN.AAT cell line resulted in alterations of the cellular physiology and a remarkable improvement of the overall performance of these cells.	Flavonoids	16-25	serpin family A member 1	Homo sapiens	59-79
22352375-0	2012	SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies.	Flavonoids	48-58	sulfotransferase family 1A member 3	Homo sapiens	0-7
22352375-8	2012	In conclusion, molecular docking studies explain why SULT1A3 exclusively mediates sulfonation at the 7-OH position of flavones/flavonols, and correlation studies indicate that SULT1A3 is the main isoform responsible for flavonoid sulfonation in the Caco-2 cells.	Flavonoids	220-229	sulfotransferase family 1A member 3	Homo sapiens	53-60
22352375-8	2012	In conclusion, molecular docking studies explain why SULT1A3 exclusively mediates sulfonation at the 7-OH position of flavones/flavonols, and correlation studies indicate that SULT1A3 is the main isoform responsible for flavonoid sulfonation in the Caco-2 cells.	Flavonoids	220-229	sulfotransferase family 1A member 3	Homo sapiens	176-183
22471389-0	2012	Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.	Flavonoids	17-27	thymoma viral proto-oncogene 1	Mus musculus	61-64
22202969-1	2012	Addition of the flavonoid quercetin to cultivations of the alpha(1)-antitrypsin (A1AT) producing human AGE1.HN.AAT cell line resulted in alterations of the cellular physiology and a remarkable improvement of the overall performance of these cells.	Flavonoids	16-25	serpin family A member 1	Homo sapiens	81-85
24250487-12	2012	These effects may be attributed due to the ACE inhibitory, vasodilatory, beta-blocking, and/ or Ca(2+) channel blocking activities, which were reported for the phytoconstitunts, specifically flavonoids such as vitexin, isovitexin, orientin, and isoorientin present in the leaves of CE.	Flavonoids	191-201	angiotensin I converting enzyme	Rattus norvegicus	43-46
21618507-0	2012	Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.	Flavonoids	151-160	mechanistic target of rapamycin kinase	Homo sapiens	57-86
22212826-3	2012	Our experimental system utilized transgenic Nicotiana tabacum plants constitutively expressing the PAP1/AtMYB75 transcription factor which activates relatively specifically the phenylpropanoid/flavonoids biosynthetic pathway.	Flavonoids	193-203	production of anthocyanin pigment 1	Arabidopsis thaliana	104-111
21915628-5	2012	In addition, flavonoids isolated from Velloziaceae showed an inhibitory effect on mutations in p53, which is mutated and nonfunctional in more than 50% of cases of human cancer.	Flavonoids	13-23	tumor protein p53	Homo sapiens	95-98
22249996-7	2012	However, a complete blocking of flavonoid biosynthesis at CHS released PAL inhibition in a tt4 ugt78d1 ugt78d2 line.	Flavonoids	32-41	UDP-glucosyl transferase 78D1	Arabidopsis thaliana	95-102
22249996-7	2012	However, a complete blocking of flavonoid biosynthesis at CHS released PAL inhibition in a tt4 ugt78d1 ugt78d2 line.	Flavonoids	32-41	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	103-110
22249996-9	2012	The dependence of the PAL feedback inhibition on flavonols was confirmed by chemical complementation of tt4 ugt78d1 ugt78d2 using naringenin, a downstream flavonoid intermediate, which restored the PAL repression.	Flavonoids	155-164	UDP-glucosyl transferase 78D1	Arabidopsis thaliana	108-115
22249996-9	2012	The dependence of the PAL feedback inhibition on flavonols was confirmed by chemical complementation of tt4 ugt78d1 ugt78d2 using naringenin, a downstream flavonoid intermediate, which restored the PAL repression.	Flavonoids	155-164	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	116-123
22353148-0	2012	Probing the binding of the flavonoid diosmetin to human serum albumin by multispectroscopic techniques.	Flavonoids	27-36	albumin	Homo sapiens	56-69
22383310-1	2012	SCOPE: This study investigated whether flavonoids, such as hesperetin and hesperidin, inhibited amyloid beta (Abeta)-impaired glucose utilization through regulating cellular autophagy in insulin-stimulated neuronal cells.	Flavonoids	39-49	amyloid beta (A4) precursor protein	Mus musculus	110-115
22300907-9	2012	The interaction between drugs and serum albumin plays an important role in the distribution and metabolism of drugs, therefore the complexation reaction between flavonoids, and berries extracts, and bovine serum albumin (BSA) was investigated by 3-D fluorescence and FTIR spectroscopy.	Flavonoids	161-171	albumin	Homo sapiens	34-47
22300907-9	2012	The interaction between drugs and serum albumin plays an important role in the distribution and metabolism of drugs, therefore the complexation reaction between flavonoids, and berries extracts, and bovine serum albumin (BSA) was investigated by 3-D fluorescence and FTIR spectroscopy.	Flavonoids	161-171	albumin	Homo sapiens	206-219
22442749-10	2012	Plant-derived polyphenols and flavonoids are identified as natural inhibitors of mTORC1 and exert anti-diabetic and anti-obesity effects.	Flavonoids	30-40	CREB regulated transcription coactivator 1	Mus musculus	81-87
22343025-1	2012	The natural flavonoid fisetin (3,3",4",7-tetrahydroxyflavone) is neurotrophic and prevents fibril formation of amyloid beta protein (Abeta).	Flavonoids	12-21	amyloid beta precursor protein	Rattus norvegicus	133-138
22343025-5	2012	3,3",4",5"-Tetrahydroxyflavone and 3",4",5"-trihydroxyflavone inhibited Abeta fibril formation far more potently than 3,3",4"-trihydroxyflavone and 3",4"-dihydroxyflavone, suggesting that 3",4",5"-trihydroxyl group of the B ring is crucial for the anti-amyloidogenic activity of flavonoids.	Flavonoids	279-289	amyloid beta precursor protein	Rattus norvegicus	72-77
22324845-0	2012	Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway.	Flavonoids	8-17	aryl hydrocarbon receptor	Homo sapiens	63-88
22320402-0	2012	Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.	Flavonoids	13-22	ATP binding cassette subfamily B member 1	Homo sapiens	48-62
22324845-3	2012	This study aims to identify new types of antiallergic dietary factors, with focus on the flavonoids with potential AhR agonistic activity.	Flavonoids	89-99	aryl hydrocarbon receptor	Homo sapiens	115-118
22324845-4	2012	Among 25 dietary flavonoid samples tested using a reporter assay, 8 showed marked induction of AhR-dependent transcriptional activity.	Flavonoids	17-26	aryl hydrocarbon receptor	Homo sapiens	95-98
22868805-6	2012	RESULTS: Minimal antiaggregatory concentrations (MINaAC) of flavonoids in individual tests were reported in the following ranges: 0.12-1.91 muM; 15.26-244.14 muM; 15.26-122.07 muM; and 0.06-15.26 muM for ADP, collagen, TRAP-6 and ristocetin aggregation-inducers, respectively.	Flavonoids	60-70	latexin	Homo sapiens	140-143
22200628-10	2012	These results suggest that the simple flavonoid, DPhP (chalcone), has valuable potential as an antiangiogenic and anti-cancer agent, and its action is mediated through the inhibition of multi-target RTKs including VEGF receptor 2.	Flavonoids	38-47	vascular endothelial growth factor A	Homo sapiens	214-218
22868805-6	2012	RESULTS: Minimal antiaggregatory concentrations (MINaAC) of flavonoids in individual tests were reported in the following ranges: 0.12-1.91 muM; 15.26-244.14 muM; 15.26-122.07 muM; and 0.06-15.26 muM for ADP, collagen, TRAP-6 and ristocetin aggregation-inducers, respectively.	Flavonoids	60-70	latexin	Homo sapiens	158-161
22868805-6	2012	RESULTS: Minimal antiaggregatory concentrations (MINaAC) of flavonoids in individual tests were reported in the following ranges: 0.12-1.91 muM; 15.26-244.14 muM; 15.26-122.07 muM; and 0.06-15.26 muM for ADP, collagen, TRAP-6 and ristocetin aggregation-inducers, respectively.	Flavonoids	60-70	latexin	Homo sapiens	158-161
22868805-6	2012	RESULTS: Minimal antiaggregatory concentrations (MINaAC) of flavonoids in individual tests were reported in the following ranges: 0.12-1.91 muM; 15.26-244.14 muM; 15.26-122.07 muM; and 0.06-15.26 muM for ADP, collagen, TRAP-6 and ristocetin aggregation-inducers, respectively.	Flavonoids	60-70	latexin	Homo sapiens	158-161
21982436-0	2012	Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract.	Flavonoids	16-26	intercellular adhesion molecule 1	Homo sapiens	60-66
22264085-0	2012	Release of flavonoids from lupin globulin proteins during digestion in a model system.	Flavonoids	11-21	5'-nucleotidase, cytosolic IIIA	Homo sapiens	27-32
22264085-1	2012	Lupin seed globulin proteins form complexes with flavonoids, predominantly apigenin C-glycosides.	Flavonoids	49-59	5'-nucleotidase, cytosolic IIIA	Homo sapiens	0-5
22264085-5	2012	Flavonoids liberated from lupin globulin proteins as a result of pancreatin-catalyzed digestion were bound by gamma-conglutin resistant to this enzyme.	Flavonoids	0-10	5'-nucleotidase, cytosolic IIIA	Homo sapiens	26-31
22293195-3	2012	Flavonoids have been shown to possess antioxidant and anti-inflammatory properties and we investigated whether flavonoids, at submicromolar concentrations relevant to their bioavailability from the diet, were able to modulate NF-kappaB signalling in astrocytes.	Flavonoids	111-121	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	226-235
21745425-4	2012	We therefore studied the interactions of a flavonoid, cyanidin and the potent Nrf2 inductor SFN in cultured human keratinocytes (HaCaT cells).	Flavonoids	43-52	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
22243648-2	2012	The tacrine fragment was selected for its inhibition of cholinesterases, and the flavonoid scaffold derived from 4-oxo-4H  -chromene was chosen for its radical capture and beta-secretase 1 (BACE-1) inhibitory activities.	Flavonoids	81-90	beta-secretase 1	Homo sapiens	172-188
22243648-2	2012	The tacrine fragment was selected for its inhibition of cholinesterases, and the flavonoid scaffold derived from 4-oxo-4H  -chromene was chosen for its radical capture and beta-secretase 1 (BACE-1) inhibitory activities.	Flavonoids	81-90	beta-secretase 1	Homo sapiens	190-196
22243648-4	2012	They are also potent inhibitors of human BACE-1, better than the parent flavonoid, apigenin.	Flavonoids	72-81	beta-secretase 1	Homo sapiens	41-47
22239530-0	2012	Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity.	Flavonoids	40-49	KRAS proto-oncogene, GTPase	Homo sapiens	89-92
22250063-6	2012	Compared with the placebo group, the combined flavonoid intervention resulted in a significant reduction in estimated peripheral insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] -0.3 +- 0.2; P = 0.004) and improvement in insulin sensitivity (quantitative insulin sensitivity index [QUICKI] 0.003 +- 0.00; P = 0.04) as a result of a significant decrease in insulin levels (-0.8 +- 0.5 mU/L; P = 0.02).	Flavonoids	46-55	insulin	Homo sapiens	129-136
22250063-6	2012	Compared with the placebo group, the combined flavonoid intervention resulted in a significant reduction in estimated peripheral insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] -0.3 +- 0.2; P = 0.004) and improvement in insulin sensitivity (quantitative insulin sensitivity index [QUICKI] 0.003 +- 0.00; P = 0.04) as a result of a significant decrease in insulin levels (-0.8 +- 0.5 mU/L; P = 0.02).	Flavonoids	46-55	insulin	Homo sapiens	181-188
22250063-6	2012	Compared with the placebo group, the combined flavonoid intervention resulted in a significant reduction in estimated peripheral insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] -0.3 +- 0.2; P = 0.004) and improvement in insulin sensitivity (quantitative insulin sensitivity index [QUICKI] 0.003 +- 0.00; P = 0.04) as a result of a significant decrease in insulin levels (-0.8 +- 0.5 mU/L; P = 0.02).	Flavonoids	46-55	insulin	Homo sapiens	181-188
22250063-6	2012	Compared with the placebo group, the combined flavonoid intervention resulted in a significant reduction in estimated peripheral insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] -0.3 +- 0.2; P = 0.004) and improvement in insulin sensitivity (quantitative insulin sensitivity index [QUICKI] 0.003 +- 0.00; P = 0.04) as a result of a significant decrease in insulin levels (-0.8 +- 0.5 mU/L; P = 0.02).	Flavonoids	46-55	insulin	Homo sapiens	181-188
22250063-6	2012	Compared with the placebo group, the combined flavonoid intervention resulted in a significant reduction in estimated peripheral insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] -0.3 +- 0.2; P = 0.004) and improvement in insulin sensitivity (quantitative insulin sensitivity index [QUICKI] 0.003 +- 0.00; P = 0.04) as a result of a significant decrease in insulin levels (-0.8 +- 0.5 mU/L; P = 0.02).	Flavonoids	46-55	insulin	Homo sapiens	181-188
21922137-0	2012	Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer             MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy.	Flavonoids	8-17	caspase 3	Homo sapiens	34-43
21922137-0	2012	Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer             MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy.	Flavonoids	8-17	caspase 7	Homo sapiens	114-123
22172500-3	2012	Both flavonoids are effective in loading the metal into the iron-transport protein transferrin.	Flavonoids	5-15	transferrin	Homo sapiens	83-94
22272764-0	2012	Flavonoids protect cerebrovascular endothelial cells through Nrf2 and PI3K from beta-amyloid peptide-induced oxidative damage.	Flavonoids	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
22071170-9	2012	In conclusion, the engineered HeLa cells overexpressing UGT1A9 is an appropriate model to study the kinetic interplay between UGT1A9 and BCRP in the phase II disposition of flavonoids.	Flavonoids	173-183	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	56-62
22071170-9	2012	In conclusion, the engineered HeLa cells overexpressing UGT1A9 is an appropriate model to study the kinetic interplay between UGT1A9 and BCRP in the phase II disposition of flavonoids.	Flavonoids	173-183	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	126-132
22071170-9	2012	In conclusion, the engineered HeLa cells overexpressing UGT1A9 is an appropriate model to study the kinetic interplay between UGT1A9 and BCRP in the phase II disposition of flavonoids.	Flavonoids	173-183	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	137-141
21445621-0	2012	The citrus flavonoid hesperidin induces p53 and inhibits NF-kappaB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARgamma-dependent mechanism.	Flavonoids	11-20	tumor protein p53	Homo sapiens	40-43
21445621-0	2012	The citrus flavonoid hesperidin induces p53 and inhibits NF-kappaB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARgamma-dependent mechanism.	Flavonoids	11-20	peroxisome proliferator activated receptor gamma	Homo sapiens	140-149
22474947-5	2012	All flavonoids inhibited murine T cell mitogenesis and IL-2 and IL-4 production without cell toxicity.	Flavonoids	4-14	interleukin 2	Mus musculus	55-59
22246885-1	2012	Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors.	Flavonoids	197-206	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	136-181
22246885-1	2012	Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors.	Flavonoids	197-206	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	183-187
22246885-1	2012	Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors.	Flavonoids	197-206	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	262-266
22474947-5	2012	All flavonoids inhibited murine T cell mitogenesis and IL-2 and IL-4 production without cell toxicity.	Flavonoids	4-14	interleukin 4	Mus musculus	64-68
22172011-0	2012	Molecular dynamic behavior and binding affinity of flavonoid analogues to the cyclin dependent kinase 6/cyclin D complex.	Flavonoids	51-60	cyclin dependent kinase 6	Homo sapiens	78-103
21971747-0	2012	Antioxidant activity of flavonoids evaluated with myoglobin method.	Flavonoids	24-34	myoglobin	Homo sapiens	50-59
22172629-0	2012	Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis.	Flavonoids	0-10	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	38-45
22172629-2	2012	The effects of flavonoids on transcriptional expression and enzyme activity of CYP11B1 were investigated using the human adrenocortical H295R cell model.	Flavonoids	15-25	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	79-86
22138516-9	2012	CONCLUSIONS: The study showed that major active component in the ethanol extract of Glycosmis pentaphylla is a flavonoid which induces apoptosis on cancer cell line, Hep3 B, by increasing the expression ratio of Bax/Bcl2 genes in a time and dose dependent manner.	Flavonoids	111-120	BCL2 associated X, apoptosis regulator	Homo sapiens	212-215
22138516-9	2012	CONCLUSIONS: The study showed that major active component in the ethanol extract of Glycosmis pentaphylla is a flavonoid which induces apoptosis on cancer cell line, Hep3 B, by increasing the expression ratio of Bax/Bcl2 genes in a time and dose dependent manner.	Flavonoids	111-120	BCL2 apoptosis regulator	Homo sapiens	216-220
22172011-0	2012	Molecular dynamic behavior and binding affinity of flavonoid analogues to the cyclin dependent kinase 6/cyclin D complex.	Flavonoids	51-60	proliferating cell nuclear antigen	Homo sapiens	78-84
22172011-4	2012	For all three inhibitors, including both CHS orientations, the conserved interaction between the 4-keto group of the flavonoid and the backbone V101 nitrogen of CDK6 was strongly detected.	Flavonoids	117-126	cyclin dependent kinase 6	Homo sapiens	161-165
22172011-6	2012	Besides the electrostatic interactions, especially through hydrogen bond formation, the van der Waals (vdW) interactions with the I19, V27, F98, H100, and L152 residues of CDK6 are also important factors in the binding efficiency of flavonoids against the CDK6/cycD complex.	Flavonoids	233-243	cyclin dependent kinase 6	Homo sapiens	172-176
22172011-6	2012	Besides the electrostatic interactions, especially through hydrogen bond formation, the van der Waals (vdW) interactions with the I19, V27, F98, H100, and L152 residues of CDK6 are also important factors in the binding efficiency of flavonoids against the CDK6/cycD complex.	Flavonoids	233-243	cyclin dependent kinase 6	Homo sapiens	256-260
22830339-7	2012	QSAR studies on flavonoids as inhibitors of breast cancer resistance protein (BCRP/ABCG2), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), PIM-1 kinase and cyclin-dependent kinases (CDKs) are analyzed.	Flavonoids	16-26	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	128-138
22696302-3	2012	We verified the previously calculated redox potentials for several flavonoids according to their rates of reduction of cytochrome c and ferricyanide, and proposed experimentally-based values of redox potentials for myricetin, fisetin, morin, kaempferol, galangin, and naringenin.	Flavonoids	67-77	cytochrome c, somatic	Homo sapiens	119-131
22696302-6	2012	It shows that although the prooxidant action of flavonoids may be the main factor in their cytotoxicity, the hydroxylation and oxidative demethylation by cytochromes P-450 and O-methylation by catechol-O-methyltransferase can significantly modulate the cytotoxicity of the parent compounds.	Flavonoids	48-58	catechol-O-methyltransferase	Homo sapiens	193-221
22745073-0	2012	Protective effects of total flavonoids from Litsea coreana on alcoholic fatty liver in rats associated with down-regulation adipose differentiation-related protein expression.	Flavonoids	28-38	perilipin 2	Rattus norvegicus	124-163
22830335-7	2012	These identified natural MDM2 inhibitors include a plethora of diverse chemical frameworks, ranging from flavonoids, steroids, and sesquiterpenes to alkaloids.	Flavonoids	105-115	MDM2 proto-oncogene	Homo sapiens	25-29
22830339-7	2012	QSAR studies on flavonoids as inhibitors of breast cancer resistance protein (BCRP/ABCG2), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), PIM-1 kinase and cyclin-dependent kinases (CDKs) are analyzed.	Flavonoids	16-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-76
22830339-7	2012	QSAR studies on flavonoids as inhibitors of breast cancer resistance protein (BCRP/ABCG2), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), PIM-1 kinase and cyclin-dependent kinases (CDKs) are analyzed.	Flavonoids	16-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	78-82
22830339-7	2012	QSAR studies on flavonoids as inhibitors of breast cancer resistance protein (BCRP/ABCG2), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), PIM-1 kinase and cyclin-dependent kinases (CDKs) are analyzed.	Flavonoids	16-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	83-88
22223373-6	2012	We here show that the radical scavenging activities of flavonoids are controlled by their absolute hardness (eta) and absolute electronegativity (chi) as a electronic state.	Flavonoids	55-65	endothelin receptor type A	Homo sapiens	109-112
22223373-8	2012	The coordinate r(chi, eta) as the electron state must be small to increase the radical scavenging activity of flavonoids.	Flavonoids	110-120	endothelin receptor type A	Homo sapiens	22-25
22830339-8	2012	Combined treatment of flavonoids with TRAIL and current chemotherapy agents is also discussed as a promising cancer chemoprevention and/or therapy.	Flavonoids	22-32	TNF superfamily member 10	Homo sapiens	38-43
22338549-1	2012	OBJECTIVE: The present study investigated the antioxidant, antiglycation and inhibitory potential of flavonoid fraction of Saraca ashoka flowers (SAF) against alpha-glucosidase and alpha-amylase (the enzymes linked to type 2 diabetes) and LDL oxidation.	Flavonoids	101-110	sucrase isomaltase (alpha-glucosidase)	Mus musculus	159-176
22830339-7	2012	QSAR studies on flavonoids as inhibitors of breast cancer resistance protein (BCRP/ABCG2), 17beta-hydroxysteroid dehydrogenase (17beta-HSD), PIM-1 kinase and cyclin-dependent kinases (CDKs) are analyzed.	Flavonoids	16-26	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	91-126
21982844-6	2012	Additional mechanisms have been suggested for the ability of flavonoids to delay the initiation of and/or slow the progression of AD-like pathology and related neurodegenerative disorders, including a potential to inhibit neuronal apoptosis triggered by neurotoxic species (e.g., oxidative stress and neuroinflammation) or disrupt amyloid beta aggregation and effects on amyloid precursor protein processing through the inhibition of beta-secretase (BACE-1) and/or activation of alpha-secretase (ADAM10).	Flavonoids	61-71	amyloid beta precursor protein	Homo sapiens	371-396
21982844-6	2012	Additional mechanisms have been suggested for the ability of flavonoids to delay the initiation of and/or slow the progression of AD-like pathology and related neurodegenerative disorders, including a potential to inhibit neuronal apoptosis triggered by neurotoxic species (e.g., oxidative stress and neuroinflammation) or disrupt amyloid beta aggregation and effects on amyloid precursor protein processing through the inhibition of beta-secretase (BACE-1) and/or activation of alpha-secretase (ADAM10).	Flavonoids	61-71	beta-secretase 1	Homo sapiens	450-456
21982844-6	2012	Additional mechanisms have been suggested for the ability of flavonoids to delay the initiation of and/or slow the progression of AD-like pathology and related neurodegenerative disorders, including a potential to inhibit neuronal apoptosis triggered by neurotoxic species (e.g., oxidative stress and neuroinflammation) or disrupt amyloid beta aggregation and effects on amyloid precursor protein processing through the inhibition of beta-secretase (BACE-1) and/or activation of alpha-secretase (ADAM10).	Flavonoids	61-71	ADAM metallopeptidase domain 10	Homo sapiens	496-502
21933852-5	2012	RESULTS: Results demonstrate that quercetin, a natural flavonoid, restores TRAIL-induced cell death in resistant transformed follicular lymphoma B-cell lines, despite high Bcl-2 expression levels due to the chromosomal translocation t(14;18).	Flavonoids	55-64	TNF superfamily member 10	Homo sapiens	75-80
22523692-6	2012	Lower PON1 activity in CRF patients is associated with low thiol concentration, high CRP, and is beneficially enhanced with vitamin C and flavonoids.	Flavonoids	138-148	paraoxonase 1	Homo sapiens	6-10
21912858-0	2012	Flavonoid production in transgenic hop (Humulus lupulus L.) altered by PAP1/MYB75 from Arabidopsis thaliana L. Hop is an important source of secondary metabolites, such as flavonoids.	Flavonoids	0-9	phosphatidic acid phosphatase 1	Arabidopsis thaliana	71-75
22155175-7	2012	An increased DAF-16 translocation and sod-3 promoter activity were observed with all flavonoids but was independent of their ROS scavenging capability and their effects on lifespan.	Flavonoids	85-95	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	13-19
22155175-7	2012	An increased DAF-16 translocation and sod-3 promoter activity were observed with all flavonoids but was independent of their ROS scavenging capability and their effects on lifespan.	Flavonoids	85-95	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	38-43
21912858-0	2012	Flavonoid production in transgenic hop (Humulus lupulus L.) altered by PAP1/MYB75 from Arabidopsis thaliana L. Hop is an important source of secondary metabolites, such as flavonoids.	Flavonoids	0-9	production of anthocyanin pigment 1	Arabidopsis thaliana	76-81
21912858-0	2012	Flavonoid production in transgenic hop (Humulus lupulus L.) altered by PAP1/MYB75 from Arabidopsis thaliana L. Hop is an important source of secondary metabolites, such as flavonoids.	Flavonoids	172-182	phosphatidic acid phosphatase 1	Arabidopsis thaliana	71-75
22080602-6	2012	Importantly, FLS2-triggered activation of PATHOGENESIS-RELATED (PR) genes and bacterial basal defenses are enhanced in transparent testa4 plants that are devoid of flavonoids, providing evidence for a functional contribution of flavonoid repression to MTI.	Flavonoids	164-174	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	13-17
21912858-0	2012	Flavonoid production in transgenic hop (Humulus lupulus L.) altered by PAP1/MYB75 from Arabidopsis thaliana L. Hop is an important source of secondary metabolites, such as flavonoids.	Flavonoids	172-182	production of anthocyanin pigment 1	Arabidopsis thaliana	76-81
22080602-6	2012	Importantly, FLS2-triggered activation of PATHOGENESIS-RELATED (PR) genes and bacterial basal defenses are enhanced in transparent testa4 plants that are devoid of flavonoids, providing evidence for a functional contribution of flavonoid repression to MTI.	Flavonoids	164-173	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	13-17
22493800-4	2012	This review is focused on the natural compounds that exhibit the aromatase inhibition, which include flavonoids, xanthones, coumarins, and sesquiterpenes.	Flavonoids	101-111	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	65-74
23209630-0	2012	The flavonoid isoquercitrin promotes neurite elongation by reducing RhoA activity.	Flavonoids	4-13	ras homolog family member A	Homo sapiens	68-72
23185345-1	2012	Previous studies have demonstrated that certain flavonoids can have an inhibitory effect on angiotensin-converting enzyme (ACE) activity, which plays a key role in the regulation of arterial blood pressure.	Flavonoids	48-58	angiotensin I converting enzyme	Homo sapiens	123-126
23185345-2	2012	In the present study, 17 flavonoids belonging to five structural subtypes were evaluated in vitro for their ability to inhibit ACE in order to establish the structural basis of their bioactivity.	Flavonoids	25-35	angiotensin I converting enzyme	Homo sapiens	127-130
23185345-3	2012	The ACE inhibitory (ACEI) activity of these 17 flavonoids was determined by fluorimetric method at two concentrations (500 microM and 100 microM).	Flavonoids	47-57	angiotensin I converting enzyme	Homo sapiens	4-7
23251498-0	2012	Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury.	Flavonoids	53-62	immunoglobulin kappa variable 4-80	Mus musculus	81-84
23251498-1	2012	We report here neuroprotective and anti-inflammatory effects of a flavonoid-enriched fraction isolated from the peel of Northern Spy apples (AF4) in a mouse of model of hypoxic-ischemic (HI) brain damage.	Flavonoids	66-75	immunoglobulin kappa variable 4-80	Mus musculus	141-144
22815676-3	2012	We sought to investigate the role these flavonoids play in inhibiting gut inflammation by an axis involving PXR and other potential factors.	Flavonoids	40-50	nuclear receptor subfamily 1, group I, member 2	Mus musculus	108-111
22815676-4	2012	The consequences of PXR regulation and activation by the herbal flavonoids, baicalein and baicalin were evaluated in vitro in human colon carcinoma cells and in vivo using wild-type, Pxr-null, and humanized (hPXR) PXR mice.	Flavonoids	64-74	nuclear receptor subfamily 1 group I member 2	Homo sapiens	20-23
22204275-3	2011	The aim of this study is to determine if the flavonoid bacailein inhibits the metastasis of skin cancer cells through Ezrin.	Flavonoids	45-54	ezrin	Mus musculus	118-123
22059530-0	2011	In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31.	Flavonoids	23-33	taste 2 receptor member 31	Homo sapiens	120-128
21924247-3	2011	Here we demonstrate that the synthetic flavonoid, 3-hydroxy-2"-methoxy-6-methylflavone (3-OH-2"MeO6MF) potentiates GABA-induced currents at recombinant alpha1/2beta2, alpha1/2/4/6beta1-3gamma2L but not alpha3/5beta1-3gamma2L receptors expressed in Xenopus oocytes.	Flavonoids	39-48	MGC75582, possible similarity to act2 S homeolog	Xenopus laevis	167-193
22074828-0	2011	Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells.	Flavonoids	0-10	intercellular adhesion molecule 1	Homo sapiens	57-63
21985641-6	2011	The results showed that UGT1A1 and 1A9, followed by 1A7, were the main isoforms for glucuronidating the two flavonoids, where UGT1A1 accounted for 92 +- 7% and 91 +- 10% of 4"-O-glucuronidation of 3,3",4"-THF and 3,6,4"-THF, respectively, and UGT1A9 accounted for most of the 3-O-glucuronidation.	Flavonoids	108-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-38
21985641-2	2011	Here, regioselective glucuronidation of two flavonoids, 3,3",4"-trihydroxyflavone (3,3",4"-THF) and 3,6,4"-trihydroxyflavone (3,6,4"-THF), is used to probe the activity of hepatic UGT1A1.	Flavonoids	44-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	180-186
22074828-0	2011	Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells.	Flavonoids	0-10	mitogen-activated protein kinase 1	Homo sapiens	72-75
21985641-4	2011	The individual contribution of main UGT isoforms to the metabolism of the two flavonoids in pHLM was estimated using the relative activity factor approach.	Flavonoids	78-88	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	36-39
21985641-5	2011	UGT1A1 activity correlation analyses using flavonoids-4"-O-glucuronidation vs beta-estradiol-3-glucuronidation (a well-recognized marker for UGT1A1) or vs SN-38 glucuronidation were performed using a bank of HLMs (n = 12) including three UGT1A1-genotyped HLMs (i.e., UGT1A1*1*1, UGT1A1*1*28, and UGT1A1*28*28).	Flavonoids	43-53	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
21985641-6	2011	The results showed that UGT1A1 and 1A9, followed by 1A7, were the main isoforms for glucuronidating the two flavonoids, where UGT1A1 accounted for 92 +- 7% and 91 +- 10% of 4"-O-glucuronidation of 3,3",4"-THF and 3,6,4"-THF, respectively, and UGT1A9 accounted for most of the 3-O-glucuronidation.	Flavonoids	108-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
21985641-6	2011	The results showed that UGT1A1 and 1A9, followed by 1A7, were the main isoforms for glucuronidating the two flavonoids, where UGT1A1 accounted for 92 +- 7% and 91 +- 10% of 4"-O-glucuronidation of 3,3",4"-THF and 3,6,4"-THF, respectively, and UGT1A9 accounted for most of the 3-O-glucuronidation.	Flavonoids	108-118	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	243-249
22074828-3	2011	We aimed to investigate the different effects of three representative flavonoids-hesperidin, naringin, and resveratrol-on intracellular adhesion molecule-1 (ICAM-1) induction in human umbilical vein endothelial cells (HUVECs) by using high-glucose (HG) concentrations and the possible underlying molecular mechanisms.	Flavonoids	70-80	intercellular adhesion molecule 1	Homo sapiens	157-163
21985641-9	2011	This study demonstrated for the first time that regioselective glucuronidation of flavonoids can be applied to probe hepatic UGT1A1 activity in vitro.	Flavonoids	82-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-131
22074828-6	2011	Pretreatment with all the three flavonoids drastically inhibited ICAM-1 expression in a time-dependent manner, but did not alter VCAM-1 and E-selectin expressions.	Flavonoids	32-42	intercellular adhesion molecule 1	Homo sapiens	65-71
22074828-8	2011	These flavonoids did not block HG-induced phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but completely inhibited the HG-induced phosphorylation of p38 MAPK.	Flavonoids	6-16	mitogen-activated protein kinase 8	Homo sapiens	134-137
22074828-8	2011	These flavonoids did not block HG-induced phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but completely inhibited the HG-induced phosphorylation of p38 MAPK.	Flavonoids	6-16	mitogen-activated protein kinase 1	Homo sapiens	199-202
21963953-1	2011	This study was to investigate the hypolipidemic and anti-inflammatory properties of Abacopterin A (APA), a flavonoid compound isolated from Abacopteris penangiana (Hook.)	Flavonoids	107-116	glutamyl aminopeptidase	Mus musculus	84-97
21830125-5	2011	To understand the possible antiangiogenic mechanism, the selected flavonoids were docked in silico onto the proangiogenic peptides such as vascular endothelial growth factor (VEGF), hypoxia inducible factor (HIF-1alpha), and vascular endothelial growth factor receptor-2 (VEGFR2) from human origin.	Flavonoids	66-76	vascular endothelial growth factor A	Homo sapiens	139-173
21830125-5	2011	To understand the possible antiangiogenic mechanism, the selected flavonoids were docked in silico onto the proangiogenic peptides such as vascular endothelial growth factor (VEGF), hypoxia inducible factor (HIF-1alpha), and vascular endothelial growth factor receptor-2 (VEGFR2) from human origin.	Flavonoids	66-76	vascular endothelial growth factor A	Homo sapiens	175-179
21830125-5	2011	To understand the possible antiangiogenic mechanism, the selected flavonoids were docked in silico onto the proangiogenic peptides such as vascular endothelial growth factor (VEGF), hypoxia inducible factor (HIF-1alpha), and vascular endothelial growth factor receptor-2 (VEGFR2) from human origin.	Flavonoids	66-76	hypoxia inducible factor 1 subunit alpha	Homo sapiens	208-218
21830125-5	2011	To understand the possible antiangiogenic mechanism, the selected flavonoids were docked in silico onto the proangiogenic peptides such as vascular endothelial growth factor (VEGF), hypoxia inducible factor (HIF-1alpha), and vascular endothelial growth factor receptor-2 (VEGFR2) from human origin.	Flavonoids	66-76	kinase insert domain receptor	Homo sapiens	225-270
21830125-5	2011	To understand the possible antiangiogenic mechanism, the selected flavonoids were docked in silico onto the proangiogenic peptides such as vascular endothelial growth factor (VEGF), hypoxia inducible factor (HIF-1alpha), and vascular endothelial growth factor receptor-2 (VEGFR2) from human origin.	Flavonoids	66-76	kinase insert domain receptor	Homo sapiens	272-278
22027102-0	2011	Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors.	Flavonoids	88-98	AKT serine/threonine kinase 1	Homo sapiens	114-117
22027102-0	2011	Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors.	Flavonoids	88-98	AKT serine/threonine kinase 1	Homo sapiens	118-122
21889496-0	2011	Regioselectivity of human UDP-glucuronosyltransferase isozymes in flavonoid biotransformation by metal complexation and tandem mass spectrometry.	Flavonoids	66-75	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	26-53
21889496-1	2011	Based on reactions with five flavonoids, the regioselectivities of twelve human UDP-glucuronosyltransferase (UGT) isozymes were elucidated.	Flavonoids	29-39	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	80-107
21889496-1	2011	Based on reactions with five flavonoids, the regioselectivities of twelve human UDP-glucuronosyltransferase (UGT) isozymes were elucidated.	Flavonoids	29-39	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	109-112
21479885-8	2011	Both flavonoids increased p53 expression in both cell lines, an effect particularly remarkable for Q.	Flavonoids	5-15	tumor protein p53	Homo sapiens	26-29
21964506-0	2011	Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress.	Flavonoids	63-73	heme oxygenase 1	Rattus norvegicus	39-55
21964506-0	2011	Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress.	Flavonoids	63-73	Eph receptor B1	Rattus norvegicus	119-122
21964506-0	2011	Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress.	Flavonoids	63-73	NFE2 like bZIP transcription factor 2	Rattus norvegicus	123-127
22071075-0	2011	The effect of Cu2+ on interaction between flavonoids with different C-ring substituents and bovine serum albumin: structure-affinity relationship aspect.	Flavonoids	42-52	albumin	Homo sapiens	99-112
23293751-3	2011	In prior studies, we found that 4"-methyl-6,6,8-triethyldesmosdumotin B (4"-Me-TEDB, 2) is an MDR-selective synthetic flavonoid with significant in vitro anticancer activity against a MDR cell line (KB-Vin) but without activity against the parent cells (KB) as well as other non-MDR tumor cells.	Flavonoids	118-127	long intergenic non-protein coding RNA 1191	Homo sapiens	202-205
22102342-9	2011	Results of multivariate analysis suggested that cas-1 was related to induction of the biosynthesis of these flavonoids.	Flavonoids	108-118	cycloartenol synthase 1	Arabidopsis thaliana	48-53
21371570-3	2011	In current work, flavonoid aglycones were studied for their affinities for bovine serum albumin (BSA) in the presence and absence of zinc oxide-zinc sulfide quantum dots (ZnO-ZnS QDs) in vitro.	Flavonoids	17-26	albumin	Homo sapiens	82-95
22066901-10	2011	LpsB was required for all the LPS species produced by NGR234, in the presence or absence of flavonoids.	Flavonoids	92-102	glycosyltransferase family 4 protein	Sinorhizobium fredii NGR234	0-4
21681413-3	2011	We previously reported the simple enzyme-linked immunosorbent assay (ELISA) systems to screen PPAR ligands and a chemical library including flavonoid derivatives have applied to these systems.	Flavonoids	140-149	peroxisome proliferator activated receptor alpha	Homo sapiens	94-98
21371570-8	2011	In this research nine flavonoid aglycones were studied for their affinities for bovine serum albumin (BSA).	Flavonoids	22-31	albumin	Homo sapiens	87-100
21785828-0	2011	The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via beta-catenin-dependent signaling.	Flavonoids	4-13	cyclin D1	Homo sapiens	79-88
22078949-11	2011	RESULTS: In vitro studies revealed that ACME has higher antioxidant and radical scavenging activity than ACHE, which may be attributed to its higher phenolic and flavonoid content.	Flavonoids	162-171	acetylcholinesterase	Rattus norvegicus	105-109
21933112-4	2011	The strict regioselective patterns are highlighted for several SULT and UGT isoforms towards flavonoids, a large class of natural polyphenols.	Flavonoids	93-103	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	72-75
21933112-6	2011	In particular, the structural basis for regioselective metabolism of flavonoids by SULT1A3 and UGT1A1 is discussed.	Flavonoids	69-79	sulfotransferase family 1A member 3	Homo sapiens	83-90
21933112-6	2011	In particular, the structural basis for regioselective metabolism of flavonoids by SULT1A3 and UGT1A1 is discussed.	Flavonoids	69-79	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	95-101
22065906-8	2011	In conclusion, flavonoids treatment induces up-regulation of p21 expression, and p21 inhibits transcription of PLK-1, which promotes apoptosis of cancer cells.	Flavonoids	15-25	H3 histone pseudogene 16	Homo sapiens	61-64
22065906-8	2011	In conclusion, flavonoids treatment induces up-regulation of p21 expression, and p21 inhibits transcription of PLK-1, which promotes apoptosis of cancer cells.	Flavonoids	15-25	polo like kinase 1	Homo sapiens	111-116
21782947-4	2011	In the present study, we established an ELISA to screen for agents that inhibit GSK3beta activity and found that the flavonoid morin effectively inhibited GSK3beta activity and blocked GSK3beta-induced tau phosphorylation in vitro.	Flavonoids	117-126	glycogen synthase kinase 3 alpha	Homo sapiens	80-88
21782947-4	2011	In the present study, we established an ELISA to screen for agents that inhibit GSK3beta activity and found that the flavonoid morin effectively inhibited GSK3beta activity and blocked GSK3beta-induced tau phosphorylation in vitro.	Flavonoids	117-126	glycogen synthase kinase 3 alpha	Homo sapiens	155-163
21782947-4	2011	In the present study, we established an ELISA to screen for agents that inhibit GSK3beta activity and found that the flavonoid morin effectively inhibited GSK3beta activity and blocked GSK3beta-induced tau phosphorylation in vitro.	Flavonoids	117-126	glycogen synthase kinase 3 alpha	Homo sapiens	155-163
21782947-4	2011	In the present study, we established an ELISA to screen for agents that inhibit GSK3beta activity and found that the flavonoid morin effectively inhibited GSK3beta activity and blocked GSK3beta-induced tau phosphorylation in vitro.	Flavonoids	117-126	microtubule associated protein tau	Homo sapiens	202-205
22086792-2	2011	This study is aimed at examining the in vitro effects of the flavonoid naringenin on PON1 activity in human serum and purified enzyme.	Flavonoids	61-70	paraoxonase 1	Homo sapiens	85-89
22086792-10	2011	Comparison of our findings and other authors showed that the induction of PON1 gene by naringenin and its inhibitory effects on the enzyme protein are probably two different mechanisms by which the flavonoid affects PON1.	Flavonoids	198-207	paraoxonase 1	Homo sapiens	74-78
22086792-10	2011	Comparison of our findings and other authors showed that the induction of PON1 gene by naringenin and its inhibitory effects on the enzyme protein are probably two different mechanisms by which the flavonoid affects PON1.	Flavonoids	198-207	paraoxonase 1	Homo sapiens	216-220
21785828-0	2011	The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via beta-catenin-dependent signaling.	Flavonoids	4-13	catenin beta 1	Homo sapiens	128-140
22088587-13	2011	CONCLUSION: Flavonoids of puerarin can restrain the increase of IL-6 after acute ischemic stroke, and depress the LDH raised by reperfusion after cerebral ischemia.	Flavonoids	12-22	interleukin 6	Homo sapiens	64-68
21863893-0	2011	Investigation of flavonoids bearing different substituents on ring C and their cu2+ complex binding with bovine serum albumin: structure-affinity relationship aspects.	Flavonoids	17-27	albumin	Homo sapiens	112-125
21924344-13	2011	leaves (ST-3) had better beneficial effect than that of the ethanol or aqueous extract in experimental diabetic rats, which means that the bioactivity of the herbal leaves is probably due to the presence of flavonoids.	Flavonoids	207-217	matrix metallopeptidase 11	Rattus norvegicus	8-12
21907578-0	2011	Relationship between the structures of flavonoids and their NF-kappaB-dependent transcriptional activities.	Flavonoids	39-49	nuclear factor kappa B subunit 1	Homo sapiens	60-69
21907578-1	2011	It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported.	Flavonoids	39-49	nuclear factor kappa B subunit 1	Homo sapiens	58-67
21907578-1	2011	It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported.	Flavonoids	39-49	tumor necrosis factor	Homo sapiens	190-198
21907578-1	2011	It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported.	Flavonoids	39-49	nuclear factor kappa B subunit 1	Homo sapiens	207-216
21907578-2	2011	Therefore, in this study, the effects of flavonoid structure on inhibition of NF-kappaB were investigated.	Flavonoids	41-50	nuclear factor kappa B subunit 1	Homo sapiens	78-87
21907578-3	2011	Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-kappaB activation.	Flavonoids	66-76	nuclear factor kappa B subunit 1	Homo sapiens	97-106
22023707-13	2011	The inhibitory effects could also be observed in cells treated with quercetin, a plant flavonoid inhibitor of Hsp27, and it could be reversed by overexpression of Hsp27.	Flavonoids	87-96	heat shock protein 1	Mus musculus	110-115
22023707-13	2011	The inhibitory effects could also be observed in cells treated with quercetin, a plant flavonoid inhibitor of Hsp27, and it could be reversed by overexpression of Hsp27.	Flavonoids	87-96	heat shock protein 1	Mus musculus	163-168
21652140-1	2011	The mechanism by which flavonoids prevent formation of amyloid-beta (Abeta) fibrils, as well as how they associate with non-fibrillar Abeta is still unclear.	Flavonoids	23-33	amyloid beta precursor protein	Homo sapiens	55-67
21635906-0	2011	Flavonoids: potential Wnt/beta-catenin signaling modulators in cancer.	Flavonoids	0-10	catenin beta 1	Homo sapiens	26-38
21652140-1	2011	The mechanism by which flavonoids prevent formation of amyloid-beta (Abeta) fibrils, as well as how they associate with non-fibrillar Abeta is still unclear.	Flavonoids	23-33	amyloid beta precursor protein	Homo sapiens	69-74
21720915-0	2011	Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.	Flavonoids	47-56	aryl hydrocarbon receptor	Homo sapiens	77-80
21720915-0	2011	Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.	Flavonoids	47-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
21769418-2	2011	Quercetin is a ubiquitous plant-derived flavonoid with well documented anti-inflammatory properties, in part, a consequence of its capacity to downmodulate the NF-kappaB signal transduction pathway.	Flavonoids	40-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	160-169
21745527-2	2011	Experimental data have shown that many flavonoids could inhibit thyroperoxidase activity, decreasing thyroid hormones levels thus increasing TSH and causing goiter.	Flavonoids	39-49	thyroid peroxidase	Homo sapiens	64-79
21743964-4	2011	Naturally occurring flavonoids can sensitize TRAIL-resistant cancer cells and augment their apoptotic activity.	Flavonoids	20-30	TNF superfamily member 10	Homo sapiens	45-50
21600261-2	2011	In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and in serum and the liver.	Flavonoids	53-63	xanthine dehydrogenase	Mus musculus	118-134
21827150-4	2011	Using the cyclic voltammetry method, the AAs of the flavonoids in the DPPH, FCR, and FRAP assays were mainly determined by the ease of charge transferring in the first oxidation step.	Flavonoids	52-62	mechanistic target of rapamycin kinase	Homo sapiens	85-89
21341175-5	2011	Four flavonoids (flavone, isorhamnetin, daidzein, and genistein) inhibited significantly LPS-induced COX-2 expression, while mPGES-1 expression was downregulated by kaempferol and isorhamnetin.	Flavonoids	5-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
21954186-8	2011	The use of a diet with an appropriate omega-3/omega-6 PUFA ratio, rich in healthy oils, fish and antioxidants, such as flavonoids, but low in cholesterol-containing foods, can be a beneficial component in the clinical strategies of prevention of AD.	Flavonoids	119-129	pumilio RNA binding family member 3	Homo sapiens	54-58
21443976-4	2011	Interestingly, the suppression of NF-kappaB activation by these flavonoids is due to inhibition of the transcriptional activation of NF-kappaB, since the compounds markedly inhibited the transcriptional activity of GAL4-NF-kappaB p65 fusion protein.	Flavonoids	64-74	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	230-233
22005287-0	2011	Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins.	Flavonoids	8-18	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
22005287-6	2011	In particular, the transcriptional factor nuclear factor erythroid 2-related factor 2 has emerged  as a critical regulator of flavonoid-mediated protection through the induction of various cytoprotective genes.	Flavonoids	126-135	NFE2 like bZIP transcription factor 2	Homo sapiens	42-85
21341175-7	2011	The results add to our knowledge of the anti-inflammatory actions of flavonoids and introduce kaempferol and isorhamnetin as compounds capable of downregulating the expression of mPGES-1.	Flavonoids	69-79	prostaglandin E synthase	Mus musculus	179-186
21861899-1	2011	BACKGROUND: Flavonoid pathway is spatially and temporally controlled during plant development and the transcriptional regulation of the structural genes is mostly orchestrated by a ternary protein complex that involves three classes of transcription factors (R2-R3-MYB, bHLH and WDR).	Flavonoids	12-21	myb-related protein 3R-1-like	Nicotiana tabacum	265-268
21861899-2	2011	In grapevine (Vitis vinifera L.), several MYB transcription factors have been identified but the interactions with their putative bHLH partners to regulate specific branches of the flavonoid pathway are still poorly understood.	Flavonoids	181-190	myb-related protein 3R-1-like	Nicotiana tabacum	42-45
21861899-10	2011	CONCLUSIONS: Taken together, our findings indicate that VvMYB5b(L) is still able to bind DNA but the structural consequences linked to the mutation affect the capacity of the protein to activate the transcription of some flavonoid genes by modifying the interaction with its co-partner(s).	Flavonoids	221-230	MYB5b	Vitis vinifera	56-63
21775671-7	2011	Induction of CYP9Q2 and CYP9Q3 transcripts by honey extracts suggested that diet-derived phytochemicals may be natural substrates and heterologous expression of CYP9Q3 confirmed activity against quercetin, a flavonoid ubiquitous in honey.	Flavonoids	208-217	cytochrome P450 9e2	Apis mellifera	13-19
21775671-7	2011	Induction of CYP9Q2 and CYP9Q3 transcripts by honey extracts suggested that diet-derived phytochemicals may be natural substrates and heterologous expression of CYP9Q3 confirmed activity against quercetin, a flavonoid ubiquitous in honey.	Flavonoids	208-217	cytochrome P450 9e2	Apis mellifera	161-167
21477081-4	2011	In this study we show that TT1 is not only required for correct expression of PA-specific genes in the seed coat, but also affects CHS, encoding the first enzyme of flavonoid biosynthesis.	Flavonoids	165-174	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	27-30
21505181-5	2011	The flavonoid apigenin, which we previously found to inhibit progestin-dependent VEGF synthesis in human breast cancer cells in vitro, significantly delayed the development of, and decreased the incidence and multiplicity of, MPA-accelerated DMBA-induced mammary tumors in this animal model.	Flavonoids	4-13	vascular endothelial growth factor A	Homo sapiens	81-85
21636741-0	2011	The quenching effect of flavonoids on 4-methylumbelliferone, a potential pitfall in fluorimetric neuraminidase inhibition assays.	Flavonoids	24-34	neuraminidase 1	Homo sapiens	97-110
21636741-3	2011	The authors attempted an analysis of the inhibitory properties of 35 naturally occurring flavonoids on neuraminidase N3, where only 29 of them were sufficiently soluble in the assay medium.	Flavonoids	89-99	neuraminidase 1	Homo sapiens	103-116
21636741-9	2011	Altogether, the collected data imply that all of the tested flavonoids could produce false-positive results in the neuraminidase inhibition assay using 4-MUNANA as a substrate.	Flavonoids	60-70	neuraminidase 1	Homo sapiens	115-128
21484270-0	2011	Flavonoid-related basic helix-loop-helix regulators, NtAn1a and NtAn1b, of tobacco have originated from two ancestors and are functionally active.	Flavonoids	0-9	basic helix-loop-helix protein A-like	Nicotiana tabacum	53-59
21484270-0	2011	Flavonoid-related basic helix-loop-helix regulators, NtAn1a and NtAn1b, of tobacco have originated from two ancestors and are functionally active.	Flavonoids	0-9	basic helix-loop-helix protein A-like	Nicotiana tabacum	64-70
21484270-4	2011	NtAn1a and NtAn1b share high sequence similarity with other known flavonoid-related bHLH TFs and are predominantly expressed in flowers.	Flavonoids	66-75	basic helix-loop-helix protein A-like	Nicotiana tabacum	0-6
21484270-4	2011	NtAn1a and NtAn1b share high sequence similarity with other known flavonoid-related bHLH TFs and are predominantly expressed in flowers.	Flavonoids	66-75	basic helix-loop-helix protein A-like	Nicotiana tabacum	11-17
21484270-8	2011	In transgenic tobacco expressing NtAn1a or NtAn1b, both subsets of early and late flavonoid pathway genes were up-regulated.	Flavonoids	82-91	basic helix-loop-helix protein A-like	Nicotiana tabacum	33-39
21543555-1	2011	UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine (SI) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n = 8/age) using villin to control for enterocyte content.	Flavonoids	54-63	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-27
21543555-1	2011	UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine (SI) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n = 8/age) using villin to control for enterocyte content.	Flavonoids	54-63	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	29-32
21409550-2	2011	The key enzyme that redirects phenylpropanoid pathway intermediates from flavonoids to isoflavonoids is the isoflavone synthase (IFS).	Flavonoids	73-83	isoflavone synthase 1	Glycine max	108-127
21409550-2	2011	The key enzyme that redirects phenylpropanoid pathway intermediates from flavonoids to isoflavonoids is the isoflavone synthase (IFS).	Flavonoids	73-83	isoflavone synthase 1	Glycine max	129-132
21484270-8	2011	In transgenic tobacco expressing NtAn1a or NtAn1b, both subsets of early and late flavonoid pathway genes were up-regulated.	Flavonoids	82-91	basic helix-loop-helix protein A-like	Nicotiana tabacum	43-49
21477081-8	2011	Based on our results we propose that the TT2/TT8/TTG1 regulon may also comprise early genes like CHS and discuss steps to further unravel the regulatory network controlling flavonoid accumulation in endothelium cells during A. thaliana seed development.	Flavonoids	173-182	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	41-44
21477081-8	2011	Based on our results we propose that the TT2/TT8/TTG1 regulon may also comprise early genes like CHS and discuss steps to further unravel the regulatory network controlling flavonoid accumulation in endothelium cells during A. thaliana seed development.	Flavonoids	173-182	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	45-48
21477081-8	2011	Based on our results we propose that the TT2/TT8/TTG1 regulon may also comprise early genes like CHS and discuss steps to further unravel the regulatory network controlling flavonoid accumulation in endothelium cells during A. thaliana seed development.	Flavonoids	173-182	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	49-53
21413806-2	2011	We systematically studied the glucuronidation of 13 flavonoids (7 flavones and 6 flavonols, with hydroxyl groups at C-3, C-4", C-5, and/or C-7 positions in flavonoid structure) at a substrate concentration of 10 muM by 8 recombinant human UGT isoforms mainly responsible for the metabolism of flavonoids, UGTs 1A1, 1A3, 1A6, 1A7, 1A8, 1A9, 1A10, and 2B7.	Flavonoids	52-62	complement C3	Homo sapiens	116-119
21651962-3	2011	7,8-Dihydroxyflavone (7,8-DHF), a member of the flavonoid family, is a selective tyrosine kinase receptor B (TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson"s disease.	Flavonoids	48-57	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	81-107
21651962-3	2011	7,8-Dihydroxyflavone (7,8-DHF), a member of the flavonoid family, is a selective tyrosine kinase receptor B (TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson"s disease.	Flavonoids	48-57	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	109-113
21413806-2	2011	We systematically studied the glucuronidation of 13 flavonoids (7 flavones and 6 flavonols, with hydroxyl groups at C-3, C-4", C-5, and/or C-7 positions in flavonoid structure) at a substrate concentration of 10 muM by 8 recombinant human UGT isoforms mainly responsible for the metabolism of flavonoids, UGTs 1A1, 1A3, 1A6, 1A7, 1A8, 1A9, 1A10, and 2B7.	Flavonoids	52-62	complement C4A (Rodgers blood group)	Homo sapiens	121-124
21413806-2	2011	We systematically studied the glucuronidation of 13 flavonoids (7 flavones and 6 flavonols, with hydroxyl groups at C-3, C-4", C-5, and/or C-7 positions in flavonoid structure) at a substrate concentration of 10 muM by 8 recombinant human UGT isoforms mainly responsible for the metabolism of flavonoids, UGTs 1A1, 1A3, 1A6, 1A7, 1A8, 1A9, 1A10, and 2B7.	Flavonoids	52-62	complement C5	Homo sapiens	127-130
21413806-2	2011	We systematically studied the glucuronidation of 13 flavonoids (7 flavones and 6 flavonols, with hydroxyl groups at C-3, C-4", C-5, and/or C-7 positions in flavonoid structure) at a substrate concentration of 10 muM by 8 recombinant human UGT isoforms mainly responsible for the metabolism of flavonoids, UGTs 1A1, 1A3, 1A6, 1A7, 1A8, 1A9, 1A10, and 2B7.	Flavonoids	52-62	complement C7	Homo sapiens	139-142
21734632-3	2011	The present study investigated whether the novel polymethoxylated flavonoid pentamethylquercetin (PMQ), a member of polymethoxylated flavonoids family which is present in seabuckthorn (Hippophae L.) would affect adiponectin production in differentiated 3T3-L1 adipocytes.	Flavonoids	66-75	adiponectin, C1Q and collagen domain containing	Mus musculus	212-223
21750559-5	2011	Therefore, we investigate here whether the sensitising activity of this flavonoid, which leads to increased apoptosis in both cell lines and CLL, could be related to Mcl-1 expression and stability.	Flavonoids	72-81	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	166-171
21745360-7	2011	All analyzed flavonoids exhibited antiaggregatory activity MINaAC ranging from 0.119 muM to 122 muM, while the most potent representatives were 3,6-dihydroxyflavone (0.119 muM) and syringetin (0.119 muM).	Flavonoids	13-23	latexin	Homo sapiens	85-88
21745360-7	2011	All analyzed flavonoids exhibited antiaggregatory activity MINaAC ranging from 0.119 muM to 122 muM, while the most potent representatives were 3,6-dihydroxyflavone (0.119 muM) and syringetin (0.119 muM).	Flavonoids	13-23	latexin	Homo sapiens	96-99
21745360-7	2011	All analyzed flavonoids exhibited antiaggregatory activity MINaAC ranging from 0.119 muM to 122 muM, while the most potent representatives were 3,6-dihydroxyflavone (0.119 muM) and syringetin (0.119 muM).	Flavonoids	13-23	latexin	Homo sapiens	96-99
21745360-7	2011	All analyzed flavonoids exhibited antiaggregatory activity MINaAC ranging from 0.119 muM to 122 muM, while the most potent representatives were 3,6-dihydroxyflavone (0.119 muM) and syringetin (0.119 muM).	Flavonoids	13-23	latexin	Homo sapiens	96-99
21458546-4	2011	We investigated if the green tea flavonoid (-)-epigallocatechin-3-gallate (EGCG), a known AhR inhibitor, is able to influence B[a]P-metabolizing and B[a]P-transporting enzymes in human Caco-2 colon carcinoma cells.	Flavonoids	33-42	aryl hydrocarbon receptor	Homo sapiens	90-93
21641214-0	2011	Flavonoids as inhibitors of human CD38.	Flavonoids	0-10	CD38 molecule	Homo sapiens	34-38
21641214-4	2011	We report that human CD38 is inhibited at low micromolar concentrations by flavonoids such as luteolinidin, kuromanin and luteolin (IC(50) &lt;10 muM).	Flavonoids	75-85	CD38 molecule	Homo sapiens	21-25
21641214-4	2011	We report that human CD38 is inhibited at low micromolar concentrations by flavonoids such as luteolinidin, kuromanin and luteolin (IC(50) &lt;10 muM).	Flavonoids	75-85	latexin	Homo sapiens	146-149
21725884-0	2011	Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis.	Flavonoids	30-40	cathepsin K	Homo sapiens	67-78
21725884-5	2011	However, there are still no detailed reports on some key issues such as the specific inhibitory results of total flavonoids on Cathepsin K and the pathway of inhibition and so on.	Flavonoids	113-123	cathepsin K	Homo sapiens	127-138
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	35-45	cathepsin K	Homo sapiens	129-140
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	35-45	cathepsin K	Homo sapiens	175-186
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	35-45	cathepsin K	Homo sapiens	175-186
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	107-117	cathepsin K	Homo sapiens	129-140
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	107-117	cathepsin K	Homo sapiens	175-186
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	107-117	cathepsin K	Homo sapiens	175-186
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	107-117	cathepsin K	Homo sapiens	129-140
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	107-117	cathepsin K	Homo sapiens	175-186
21725884-6	2011	Based on previous studies on total flavonoids from Rhizoma Drynariae, the pathway for the effect of, total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper, so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.	Flavonoids	107-117	cathepsin K	Homo sapiens	175-186
21515260-2	2011	The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-lipoxygenase, oxidative-nitrosative stress, inflammation, and impaired signaling in models of chronic disease.	Flavonoids	4-13	arachidonate 15-lipoxygenase	Mus musculus	119-137
21377758-10	2011	Furthermore, the biochemical changes observed in Pds-silenced detached tomatoes suggested that carotenoid and other pathways, e.g. leading to alkaloids and flavonoids, might be affected by the silencing of this reporter gene, and this should be taken into consideration for future experimental designs.	Flavonoids	156-166	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum	49-52
21834230-6	2011	The flavonoids 3,5-dihydroxy-7-methoxy-flavanone and 3,5-dihydroxy-7-methoxyflavone at a concentration of 25 microg/mL increased the expression of costimulatory molecules corresponding to the phenotype presented by mature dendritic cells with differentiation markers CD40, CD83, CD86 and HLA-DR.	Flavonoids	4-14	CD40 molecule	Homo sapiens	267-271
21834230-6	2011	The flavonoids 3,5-dihydroxy-7-methoxy-flavanone and 3,5-dihydroxy-7-methoxyflavone at a concentration of 25 microg/mL increased the expression of costimulatory molecules corresponding to the phenotype presented by mature dendritic cells with differentiation markers CD40, CD83, CD86 and HLA-DR.	Flavonoids	4-14	CD83 molecule	Homo sapiens	273-277
21834230-6	2011	The flavonoids 3,5-dihydroxy-7-methoxy-flavanone and 3,5-dihydroxy-7-methoxyflavone at a concentration of 25 microg/mL increased the expression of costimulatory molecules corresponding to the phenotype presented by mature dendritic cells with differentiation markers CD40, CD83, CD86 and HLA-DR.	Flavonoids	4-14	CD86 molecule	Homo sapiens	279-283
21170924-5	2011	VEGF and TGF-beta1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4"-dimethoxyflavone, casticin, apigenin and penduletin.	Flavonoids	110-120	vascular endothelial growth factor A	Homo sapiens	0-4
21265826-8	2011	MyoD-induced myogenin gene transcription was enhanced by hesperedin, as this bioflavonoid augmented the nuclear localization and myogenin promoter-binding of MyoD.	Flavonoids	77-89	myogenic differentiation 1	Mus musculus	0-4
21402146-3	2011	Using a cell-based ARE-reporter assay we discovered that the flavonoid luteolin is a potent Nrf2 inhibitor.	Flavonoids	61-70	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
21402146-8	2011	However, knockdown of Nrf2 using siRNA essentially abolished the induced sensitivity by the flavonoid, implying the importance of inhibiting Nrf2 for its activity.	Flavonoids	92-101	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
21402146-8	2011	However, knockdown of Nrf2 using siRNA essentially abolished the induced sensitivity by the flavonoid, implying the importance of inhibiting Nrf2 for its activity.	Flavonoids	92-101	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
21384377-1	2011	BACKGROUND: The present study was designed to investigate the hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L. (FSH) in a high-fat diet fed mouse model.	Flavonoids	112-122	follicle stimulating hormone beta	Mus musculus	170-173
25213920-9	2011	Flavonoids, which are characterised as natural AhR ligands, are known to have representative beneficial effects on human health.	Flavonoids	0-10	aryl hydrocarbon receptor	Homo sapiens	47-50
25213953-3	2011	Results showed that the fraction with high phenolic and flavonoid contents from the ethanol extracts of adlay bran suppressed LPS-stimulated IL-6 and TNF-alpha secretions in a concentration-dependent manner in RAW 264.7 cells and murine peritoneal macrophages.	Flavonoids	56-65	interleukin 6	Mus musculus	141-145
25213953-3	2011	Results showed that the fraction with high phenolic and flavonoid contents from the ethanol extracts of adlay bran suppressed LPS-stimulated IL-6 and TNF-alpha secretions in a concentration-dependent manner in RAW 264.7 cells and murine peritoneal macrophages.	Flavonoids	56-65	tumor necrosis factor	Mus musculus	150-159
21265826-8	2011	MyoD-induced myogenin gene transcription was enhanced by hesperedin, as this bioflavonoid augmented the nuclear localization and myogenin promoter-binding of MyoD.	Flavonoids	77-89	myogenin	Mus musculus	13-21
21265826-8	2011	MyoD-induced myogenin gene transcription was enhanced by hesperedin, as this bioflavonoid augmented the nuclear localization and myogenin promoter-binding of MyoD.	Flavonoids	77-89	myogenin	Mus musculus	129-137
21265826-8	2011	MyoD-induced myogenin gene transcription was enhanced by hesperedin, as this bioflavonoid augmented the nuclear localization and myogenin promoter-binding of MyoD.	Flavonoids	77-89	myogenic differentiation 1	Mus musculus	158-162
21535269-5	2011	DNA fragmentation was observed after treatment with flavonoids; this was confirmed by demonstration of PARP cleavage.	Flavonoids	52-62	poly(ADP-ribose) polymerase 1	Homo sapiens	103-107
21535269-6	2011	Caspase-3 and caspase-8 activities were induced by both K3O-ir and R3O-ir flavonoids showing highest activity with compound concentration of 400 mug/ml.	Flavonoids	74-84	caspase 3	Homo sapiens	0-9
21535269-6	2011	Caspase-3 and caspase-8 activities were induced by both K3O-ir and R3O-ir flavonoids showing highest activity with compound concentration of 400 mug/ml.	Flavonoids	74-84	caspase 8	Homo sapiens	14-23
21622274-5	2011	The molecular mechanisms of the anticarcinogenic effects of flavonoids include their antagonistic effect on the aryl hydrocarbon receptor (AhR), and regulation of phase I and II drug metabolizing enzymes and phase III transporters.	Flavonoids	60-70	aryl hydrocarbon receptor	Homo sapiens	112-137
21622274-5	2011	The molecular mechanisms of the anticarcinogenic effects of flavonoids include their antagonistic effect on the aryl hydrocarbon receptor (AhR), and regulation of phase I and II drug metabolizing enzymes and phase III transporters.	Flavonoids	60-70	aryl hydrocarbon receptor	Homo sapiens	139-142
21346776-0	2011	Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/beta-catenin signaling and decreased Mitf levels.	Flavonoids	56-65	catenin beta 1	Homo sapiens	111-123
21346776-0	2011	Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/beta-catenin signaling and decreased Mitf levels.	Flavonoids	56-65	melanocyte inducing transcription factor	Homo sapiens	148-152
21365186-0	2011	The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities.	Flavonoids	18-27	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	46-54
21365186-0	2011	The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities.	Flavonoids	18-27	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	59-67
21365186-6	2011	Additionally, glycosaminoglycan levels in culture medium of murine cartilage explants stimulated with interleukin-1-alpha plus retinoic acid are reduced by the presence of the flavonoid.	Flavonoids	176-185	interleukin 1 alpha	Mus musculus	102-121
21699081-2	2011	These Citrus flavonoids are known as P-glycoprotein (P-gp) inhibitors and thus suspected to interact with doxorubicin, as shown by in vitro cell studies.	Flavonoids	13-23	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	37-51
21699081-2	2011	These Citrus flavonoids are known as P-glycoprotein (P-gp) inhibitors and thus suspected to interact with doxorubicin, as shown by in vitro cell studies.	Flavonoids	13-23	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	53-57
21699081-4	2011	To evaluate the impact of the biotransformation of Citrus flavonoids on the P-gp inhibition, the inhibitory effects of quercetin and its metabolite on P-gp were compared using ex vivo analysis.	Flavonoids	58-68	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	76-80
21502189-4	2011	The hyponastic cotyledons, aberrant shape of pavement cells, and deformed trichomes in rol1-2 mutants are suppressed by blocking flavonoid biosynthesis, suggesting that the altered flavonol accumulation in these plants induces the shoot phenotype.	Flavonoids	129-138	rhamnose biosynthesis 1	Arabidopsis thaliana	87-93
21170924-5	2011	VEGF and TGF-beta1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4"-dimethoxyflavone, casticin, apigenin and penduletin.	Flavonoids	110-120	transforming growth factor beta 1	Homo sapiens	9-18
21170924-6	2011	Rutin reduced the VEGF and TGF-beta1 levels after 24 h but not after 72 h. The other flavonoids significantly reduced TGF-beta1 production.	Flavonoids	85-95	transforming growth factor beta 1	Homo sapiens	118-127
21482471-0	2011	Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.	Flavonoids	73-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-18
24278554-1	2011	We demonstrate that baicalein, a bioactive flavonoid originally isolated from Scutellaria baicalensis, inhibits LPS-induced expression of iNOS gene in RAW 264.7 cells.	Flavonoids	43-52	nitric oxide synthase 2, inducible	Mus musculus	138-142
21425871-5	2011	The structure-activity analysis indicated that a fully methoxylated A-ring of the flavonoid structure was associated with a potent inhibitory activity on hepatic apoB secretion.	Flavonoids	82-91	apolipoprotein B	Homo sapiens	162-166
21425871-6	2011	In conclusion, this study using HepG2 cells indicates that citrus flavonoids with a fully methoxylated A-ring may lower blood CH and TG concentrations primarily by suppressing hepatic apoB secretion as a main underlying mode of action.	Flavonoids	66-76	apolipoprotein B	Homo sapiens	184-188
21329749-8	2011	The inhibitory potency of flavonols on CYP1A1 activity in presence of B[a]P was much stronger for the aglycones than for the 3-O-rutinosides, explaining the slight effect observed with the GBE, mainly composed of glycosylated flavonoids.	Flavonoids	226-236	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
21586116-3	2011	The current study presents a single molecule of bovine serum albumin (BSA), lysozyme (Lys), or myoglobin (Mb) used to load hydrophobic drugs such as quercetin (Q) and other flavonoids.	Flavonoids	173-183	lysozyme	Homo sapiens	76-84
21586116-3	2011	The current study presents a single molecule of bovine serum albumin (BSA), lysozyme (Lys), or myoglobin (Mb) used to load hydrophobic drugs such as quercetin (Q) and other flavonoids.	Flavonoids	173-183	myoglobin	Homo sapiens	95-104
21425871-0	2011	Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion.	Flavonoids	31-41	apolipoprotein B	Homo sapiens	126-130
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	Flavonoids	46-56	apolipoprotein B	Homo sapiens	110-114
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	Flavonoids	46-56	latexin	Homo sapiens	145-148
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	Flavonoids	46-56	latexin	Homo sapiens	220-223
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	Flavonoids	46-56	latexin	Homo sapiens	220-223
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	Flavonoids	46-56	low density lipoprotein receptor	Homo sapiens	286-298
21482471-9	2011	Homology modeling in conjunction with molecular docking calculations were employed in an effort to rationalize the activity of these flavonoids based on their CYP1-binding mode.	Flavonoids	133-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	159-163
21482471-10	2011	Taken together the data suggest that dietary flavonoids exhibit three distinct modes of action with regard to cancer prevention, based on their hydroxyl and methoxy decoration: (1) inhibitors of CYP1 enzymatic activity, (2) CYP1 substrates and (3) substrates and inhibitors of CYP1 enzymes.	Flavonoids	45-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	195-199
21482471-10	2011	Taken together the data suggest that dietary flavonoids exhibit three distinct modes of action with regard to cancer prevention, based on their hydroxyl and methoxy decoration: (1) inhibitors of CYP1 enzymatic activity, (2) CYP1 substrates and (3) substrates and inhibitors of CYP1 enzymes.	Flavonoids	45-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	224-228
21482471-10	2011	Taken together the data suggest that dietary flavonoids exhibit three distinct modes of action with regard to cancer prevention, based on their hydroxyl and methoxy decoration: (1) inhibitors of CYP1 enzymatic activity, (2) CYP1 substrates and (3) substrates and inhibitors of CYP1 enzymes.	Flavonoids	45-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	224-228
21482471-0	2011	Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.	Flavonoids	73-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	23-29
21482471-2	2011	Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class of flavonoids, is a widely accepted paradigm that supports the concept of dietary chemoprevention.	Flavonoids	88-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-30
21482471-2	2011	Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class of flavonoids, is a widely accepted paradigm that supports the concept of dietary chemoprevention.	Flavonoids	88-98	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	35-41
21482471-3	2011	In parallel, recent studies have documented the ability of CYP1 enzymes to selectively metabolize dietary flavonoids to conversion products that inhibit cancer cell proliferation.	Flavonoids	106-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-63
21482471-4	2011	In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1.	Flavonoids	114-124	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
21482471-4	2011	In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1.	Flavonoids	114-124	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	67-73
21482471-4	2011	In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1.	Flavonoids	114-124	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-60
21482471-4	2011	In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1.	Flavonoids	114-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
21482471-4	2011	In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1.	Flavonoids	114-123	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	67-73
21482471-4	2011	In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1.	Flavonoids	114-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-60
21244849-0	2011	Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).	Flavonoids	0-9	solute carrier family 22 member 6	Homo sapiens	149-153
22009597-0	2011	Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariectomized rats.	Flavonoids	76-86	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	22-26
22009597-1	2011	OBJECTIVE: To observe the dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids (EFs) regulate the balance between osteogenic and adipogenic differentiation of bone marrow stromal cells in ovariectomized rats, and to provide experimental evidence for the mechanism of EFs in the treatment of postmenopausal osteoporosis.	Flavonoids	102-112	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	48-52
21077260-6	2011	Nevertheless, the C-5 hydroxyl group of prenylated flavonoids is important for inhibition of BACE1 and ChEs, indicating that the hydroxyl group at C-5 might be the main contributor to the augmentation and/or modification of prenylated flavonol activity.	Flavonoids	51-61	beta-secretase 1	Homo sapiens	93-98
21842655-4	2011	Secretion of MMP-2 was measured by ELISA in the supernatant of SMMC-7721 cells treated with fractions of essential oil and total flavonoids for 24 h. Transcription of mRNA of MMP-2 was detected by Real-time PCR.	Flavonoids	129-139	matrix metallopeptidase 2	Homo sapiens	13-18
21842655-4	2011	Secretion of MMP-2 was measured by ELISA in the supernatant of SMMC-7721 cells treated with fractions of essential oil and total flavonoids for 24 h. Transcription of mRNA of MMP-2 was detected by Real-time PCR.	Flavonoids	129-139	matrix metallopeptidase 2	Homo sapiens	175-180
21842655-7	2011	Results of Real-time PCR indicated that both essential oil and total flavonoids restrained expression of mRNA of MMP-2.	Flavonoids	69-79	matrix metallopeptidase 2	Homo sapiens	113-118
21842655-8	2011	CONCLUSION: It suggested that essential oil and total flavonoids of O. falcata inhibit proliferation of SMMC-7721 cells through down-regulating secretion and expression of MMP-2 in cells.	Flavonoids	54-64	matrix metallopeptidase 2	Homo sapiens	172-177
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	80-89	solute carrier family 22 member 6	Homo sapiens	24-28
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	80-89	solute carrier family 22 member 8	Homo sapiens	33-37
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	80-89	solute carrier family 22 member 8	Homo sapiens	154-158
21280205-0	2011	Effect of flavonoids on basal and insulin-stimulated 2-deoxyglucose uptake in adipocytes.	Flavonoids	10-20	insulin	Homo sapiens	34-41
21279423-0	2011	5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice.	Flavonoids	34-44	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	70-75
21488180-9	2011	TBK1 kinase can be a target for certain flavonoids such as EGCG, luteolin, quercetin, chrysin, and eriodictyol to regulate TRIF-dependent TLR pathways.	Flavonoids	40-50	TANK binding kinase 1	Homo sapiens	0-4
21488180-9	2011	TBK1 kinase can be a target for certain flavonoids such as EGCG, luteolin, quercetin, chrysin, and eriodictyol to regulate TRIF-dependent TLR pathways.	Flavonoids	40-50	TIR domain containing adaptor molecule 1	Homo sapiens	123-127
21544726-1	2011	Quercetin, a flavonoid, is an inhibitor of P-glycoprotein-mediated efflux transport, and its oxidative metabolism is catalyzed by CYP enzymes.	Flavonoids	13-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	43-57
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	116-125	solute carrier family 22 member 6	Homo sapiens	145-149
21244849-12	2011	These data suggest that OAT1 and OAT3 are responsible for basolateral uptake of flavonoid conjugates in kidney, and flavonoid conjugates inhibit OAT1 and OAT3 activity at physiologically relevant concentrations.	Flavonoids	116-125	solute carrier family 22 member 8	Homo sapiens	154-158
21244849-3	2011	Accumulation of flavonoid conjugates was studied in human embryonic kidney 293H cells overexpressing OAT1 or OAT3.	Flavonoids	16-25	solute carrier family 22 member 6	Homo sapiens	101-105
21244849-3	2011	Accumulation of flavonoid conjugates was studied in human embryonic kidney 293H cells overexpressing OAT1 or OAT3.	Flavonoids	16-25	solute carrier family 22 member 8	Homo sapiens	109-113
21118093-1	2011	ABCG2, or breast cancer resistance protein (BCRP), is an ATP-binding cassette half transporter that has been shown to transport a wide range of substrates including chemotherapeutics, antivirals, antibiotics and flavonoids.	Flavonoids	212-222	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-5
21198542-10	2011	The inhibition of p70S6K phosphorylation by 4"-OH-TMF raises the possibility that inhibition of the mTOR pathway may contribute to the anticancer influence of a flavonoid-rich diet.	Flavonoids	161-170	ribosomal protein S6 kinase B1	Rattus norvegicus	18-24
21198542-10	2011	The inhibition of p70S6K phosphorylation by 4"-OH-TMF raises the possibility that inhibition of the mTOR pathway may contribute to the anticancer influence of a flavonoid-rich diet.	Flavonoids	161-170	mechanistic target of rapamycin kinase	Rattus norvegicus	100-104
21298326-0	2011	The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells.	Flavonoids	12-21	dipeptidyl peptidase 4	Homo sapiens	86-90
21118093-1	2011	ABCG2, or breast cancer resistance protein (BCRP), is an ATP-binding cassette half transporter that has been shown to transport a wide range of substrates including chemotherapeutics, antivirals, antibiotics and flavonoids.	Flavonoids	212-222	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	10-42
21118093-1	2011	ABCG2, or breast cancer resistance protein (BCRP), is an ATP-binding cassette half transporter that has been shown to transport a wide range of substrates including chemotherapeutics, antivirals, antibiotics and flavonoids.	Flavonoids	212-222	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-48
21118093-1	2011	ABCG2, or breast cancer resistance protein (BCRP), is an ATP-binding cassette half transporter that has been shown to transport a wide range of substrates including chemotherapeutics, antivirals, antibiotics and flavonoids.	Flavonoids	212-222	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	57-94
21325476-10	2011	In particular, flavonoids typically found in citrus fruits were modestly associated with lower plasma IL-18 concentrations.	Flavonoids	15-25	interleukin 18	Homo sapiens	102-107
21443429-0	2011	Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3beta enzymatic activity by lowering the interaction energy within the binding cavity.	Flavonoids	7-17	glycogen synthase kinase 3 beta	Homo sapiens	60-90
21443429-3	2011	Of the 22 citrus compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3beta, with 50% inhibitory values of 1.5, 1.9, and 2.0 muM, respectively.	Flavonoids	39-49	glycogen synthase kinase 3 beta	Homo sapiens	122-131
21443429-3	2011	Of the 22 citrus compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3beta, with 50% inhibitory values of 1.5, 1.9, and 2.0 muM, respectively.	Flavonoids	39-49	latexin	Homo sapiens	181-184
21443429-4	2011	Molecular dockings were then performed to determine the potential interactions of each citrus flavonoid with GSK-3beta.	Flavonoids	94-103	glycogen synthase kinase 3 beta	Homo sapiens	109-118
21443429-6	2011	Our results indicate that several citrus flavonoids inhibit GSK-3beta activity and suggest that these have potential to suppress the growth of pancreatic tumors.	Flavonoids	41-51	glycogen synthase kinase 3 beta	Homo sapiens	60-69
21247706-7	2011	In this scenario, we propose honey with multitude of polyphenolic flavonoids as a plausible candidate for inhibiting the P-gp proteins.	Flavonoids	66-76	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
21247706-8	2011	Common flavonoids of honey like chrysin, genistein, biochanin, quercetin, kaempferol, and naringenin have found to interact with P-gp transporters.	Flavonoids	7-17	ATP binding cassette subfamily B member 1	Homo sapiens	129-133
21247706-9	2011	Generally chemosensitizers bind with transmembrane domain (TMD) in the P-gp transporter but flavonoids are bi-functional in reversing the MDR.	Flavonoids	92-102	ATP binding cassette subfamily B member 1	Homo sapiens	71-75
21247706-10	2011	Flavonoids can inhibit the ATPases activity involved in drug efflux and also it may serve as substrates for P-gp transporters, thereby causing competitive inhibition towards other substrates.	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	108-112
21247706-11	2011	This dual-mode of flavonoids interaction with P-gp transporter enhances the therapeutic index.	Flavonoids	18-28	ATP binding cassette subfamily B member 1	Homo sapiens	46-50
21309574-0	2011	Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1alpha.	Flavonoids	0-10	erythropoietin	Homo sapiens	57-71
21295043-7	2011	Both flavonoids increased the secretion of an insulin-sensitizing factor, adiponectin, but concomitantly decreased the secretion of an insulin-resistance factor, MCP-1, in 3T3-L1 adipocytes.	Flavonoids	5-15	adiponectin, C1Q and collagen domain containing	Mus musculus	74-85
21295043-7	2011	Both flavonoids increased the secretion of an insulin-sensitizing factor, adiponectin, but concomitantly decreased the secretion of an insulin-resistance factor, MCP-1, in 3T3-L1 adipocytes.	Flavonoids	5-15	mast cell protease 1	Mus musculus	162-167
21354800-0	2011	Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).	Flavonoids	36-46	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	98-102
21354800-3	2011	However, several flavonoids have been reported to inhibit the breast cancer resistance protein (BCRP) encoded by the ABCG2 gene.	Flavonoids	17-27	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	62-94
21354800-3	2011	However, several flavonoids have been reported to inhibit the breast cancer resistance protein (BCRP) encoded by the ABCG2 gene.	Flavonoids	17-27	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	96-100
21354800-3	2011	However, several flavonoids have been reported to inhibit the breast cancer resistance protein (BCRP) encoded by the ABCG2 gene.	Flavonoids	17-27	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	117-122
21354800-4	2011	Thus, the consumption of flavonoids with high inhibitory activity could change pharmacokinetics and drug levels of drugs that are BCRP substrates.	Flavonoids	25-35	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	130-134
21256954-0	2011	Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.	Flavonoids	51-61	aryl hydrocarbon receptor	Homo sapiens	69-72
21256954-0	2011	Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2.	Flavonoids	51-61	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
21256954-1	2011	As phytochemicals have the potential to counteract adverse effects of carcinogens we investigated the influence of the flavonoids quercetin and kaempferol on benzo[a]pyrene (BaP) mediated effects on human colon cancer cells, Caco-2.	Flavonoids	119-129	prohibitin 2	Homo sapiens	174-177
21256954-5	2011	The flavonoids did not affect AhR expression but counteracted the BaP mediated AhRR repression.	Flavonoids	4-14	prohibitin 2	Homo sapiens	66-69
21256954-5	2011	The flavonoids did not affect AhR expression but counteracted the BaP mediated AhRR repression.	Flavonoids	4-14	aryl hydrocarbon receptor repressor	Homo sapiens	79-83
21256954-7	2011	ARNT mRNA appeared to be slightly but significantly down-regulated by BaP as well as by flavonoids while expression of AIP was not or only slightly modulated.	Flavonoids	88-98	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	0-4
21256954-8	2011	The Nrf2 pathway was activated by BaP and by the flavonoids shown by induction of Nrf2 and several of its target genes such as NQO1, GSTP1, GSTA1 and GCLC.	Flavonoids	49-59	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
21256954-8	2011	The Nrf2 pathway was activated by BaP and by the flavonoids shown by induction of Nrf2 and several of its target genes such as NQO1, GSTP1, GSTA1 and GCLC.	Flavonoids	49-59	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
21256954-8	2011	The Nrf2 pathway was activated by BaP and by the flavonoids shown by induction of Nrf2 and several of its target genes such as NQO1, GSTP1, GSTA1 and GCLC.	Flavonoids	49-59	NAD(P)H quinone dehydrogenase 1	Homo sapiens	127-131
21256954-8	2011	The Nrf2 pathway was activated by BaP and by the flavonoids shown by induction of Nrf2 and several of its target genes such as NQO1, GSTP1, GSTA1 and GCLC.	Flavonoids	49-59	glutathione S-transferase pi 1	Homo sapiens	133-138
21256954-8	2011	The Nrf2 pathway was activated by BaP and by the flavonoids shown by induction of Nrf2 and several of its target genes such as NQO1, GSTP1, GSTA1 and GCLC.	Flavonoids	49-59	glutathione S-transferase alpha 1	Homo sapiens	140-145
21256954-8	2011	The Nrf2 pathway was activated by BaP and by the flavonoids shown by induction of Nrf2 and several of its target genes such as NQO1, GSTP1, GSTA1 and GCLC.	Flavonoids	49-59	glutamate-cysteine ligase catalytic subunit	Homo sapiens	150-154
21256954-9	2011	Induction effects of 10 mum BaP on Nrf2, GSTP1 and NQO1 were abolished by the flavonoids.	Flavonoids	78-88	prohibitin 2	Homo sapiens	28-31
21256954-9	2011	Induction effects of 10 mum BaP on Nrf2, GSTP1 and NQO1 were abolished by the flavonoids.	Flavonoids	78-88	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
21256954-9	2011	Induction effects of 10 mum BaP on Nrf2, GSTP1 and NQO1 were abolished by the flavonoids.	Flavonoids	78-88	NAD(P)H quinone dehydrogenase 1	Homo sapiens	51-55
21256954-11	2011	Both flavonoids, however, may counteract the effects of BaP on expression of AhR, AhRR, Nrf2, GSTP1 and NQO1.	Flavonoids	5-15	prohibitin 2	Homo sapiens	56-59
21256954-11	2011	Both flavonoids, however, may counteract the effects of BaP on expression of AhR, AhRR, Nrf2, GSTP1 and NQO1.	Flavonoids	5-15	aryl hydrocarbon receptor	Homo sapiens	77-80
21256954-11	2011	Both flavonoids, however, may counteract the effects of BaP on expression of AhR, AhRR, Nrf2, GSTP1 and NQO1.	Flavonoids	5-15	aryl hydrocarbon receptor repressor	Homo sapiens	82-86
21256954-11	2011	Both flavonoids, however, may counteract the effects of BaP on expression of AhR, AhRR, Nrf2, GSTP1 and NQO1.	Flavonoids	5-15	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
21256954-11	2011	Both flavonoids, however, may counteract the effects of BaP on expression of AhR, AhRR, Nrf2, GSTP1 and NQO1.	Flavonoids	5-15	glutathione S-transferase pi 1	Homo sapiens	94-99
21256954-11	2011	Both flavonoids, however, may counteract the effects of BaP on expression of AhR, AhRR, Nrf2, GSTP1 and NQO1.	Flavonoids	5-15	NAD(P)H quinone dehydrogenase 1	Homo sapiens	104-108
21362404-10	2011	Thus, the inhibition of tumor growth, survival increase, decrease of MMP-2 and VEGF levels and reduction of cachexia in animals treated with quercetin strongly support the anticancer function of this flavonoid.	Flavonoids	200-209	matrix metallopeptidase 2	Rattus norvegicus	69-74
21362404-10	2011	Thus, the inhibition of tumor growth, survival increase, decrease of MMP-2 and VEGF levels and reduction of cachexia in animals treated with quercetin strongly support the anticancer function of this flavonoid.	Flavonoids	200-209	vascular endothelial growth factor A	Rattus norvegicus	79-83
21354800-0	2011	Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).	Flavonoids	36-46	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	64-96
21271629-4	2011	Our results revealed that baicalein, a flavonoid extracted from the Chinese herbal medicine Scutellaria baicalensis Georgi ("huang qin" in Chinese), is a potent inhibitor of alpha-syn oligomerisation both in cell-free and cellular systems, and is also an effective inhibitor of alpha-syn fibrillation in cell-free systems.	Flavonoids	39-48	synuclein alpha	Homo sapiens	174-183
21309574-0	2011	Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1alpha.	Flavonoids	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-167
21309574-6	2011	To account for the transcriptional activation after the treatment of flavonoids, the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) was markedly increased: The increase was in both mRNA and protein levels.	Flavonoids	69-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-130
21309574-6	2011	To account for the transcriptional activation after the treatment of flavonoids, the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) was markedly increased: The increase was in both mRNA and protein levels.	Flavonoids	69-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-142
21309574-7	2011	In addition, the degradation of HIF-1alpha was reduced under the effect of flavonoids.	Flavonoids	75-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
21408135-9	2011	The flavonoid profile in cold-induced transgenic plants was determined by LC/MS/MS, which resembled that of previously reported pap1-D plants but enriched for kaempferol derivatives.	Flavonoids	4-13	production of anthocyanin pigment 1	Arabidopsis thaliana	128-132
21309574-8	2011	The regulation of HIF-1alpha therefore could account for the activation of EPO expression mediated by the RA flavonoids.	Flavonoids	109-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
21408135-11	2011	Furthermore, we show that PAP1 and environmental signals synergistically regulate the flavonoid pathway to produce a unique flavonoid blend that has not been produced by PAP1 overexpression or cold treatment alone.	Flavonoids	86-95	production of anthocyanin pigment 1	Arabidopsis thaliana	26-30
21309574-8	2011	The regulation of HIF-1alpha therefore could account for the activation of EPO expression mediated by the RA flavonoids.	Flavonoids	109-119	erythropoietin	Homo sapiens	75-78
21133890-2	2011	The aim of the current investigation was to evaluate the role of the flavonoid baicalein in long-term potentiation (LTP) in the hippocampal CA1 region and cognitive behavioural performance.	Flavonoids	69-78	carbonic anhydrase 1	Rattus norvegicus	140-143
21367373-2	2011	The aim of this study was to examine hesperetin, a flavonoid, as a potential Notch1 activator and carcinoid tumor suppressor.	Flavonoids	51-60	notch receptor 1	Homo sapiens	77-83
21216897-3	2011	Examination of these recombinant, partially purified polypeptides for hydrolytic activity with synthetic chromogenic alpha- or beta-glucosides identified three efficient beta-glucosidases (EXG1, SPR1, and YIR007W), which were further assayed with natural flavonoid beta-glucoside substrates and product verification by thin-layer chromatography (TLC) or high-performance liquid chromatography (HPLC).	Flavonoids	255-264	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	189-193
21216897-6	2011	Most importantly, biotransformation experiments with knockout yeast strains revealed that only EXG1 knockout strains lost the capability to hydrolyze flavonoid glucosides.	Flavonoids	150-159	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	95-99
20677908-0	2011	Inhibition of LXRalpha-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.	Flavonoids	94-103	nuclear receptor subfamily 1, group H, member 3	Mus musculus	14-22
20677908-0	2011	Inhibition of LXRalpha-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.	Flavonoids	94-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126
21139040-0	2011	The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux.	Flavonoids	4-16	ATP binding cassette subfamily G member 2	Canis lupus familiaris	34-39
21550553-6	2011	Flavonoid vascular disrupting agents appear to accentuate pathologic signaling by cytokines such as tumor necrosis factor and vascular endothelial growth factor, leading to changes in the actin cytoskeleton, increased vascular permeability, and endothelial apoptosis.	Flavonoids	0-9	vascular endothelial growth factor A	Homo sapiens	126-160
21139040-0	2011	The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux.	Flavonoids	4-16	ATP binding cassette subfamily G member 2	Canis lupus familiaris	63-68
20828867-4	2011	The present study was designed to examine the involvement of TLR2 and TLR4 in the oxidized LDL induced inflammation in human PBMCs and the effect of flavonoid quercetin on TLR-NF-kappaB signaling mechanism.	Flavonoids	149-158	nuclear factor kappa B subunit 1	Homo sapiens	176-185
21328458-4	2011	Both flavonoids dose-dependently reduce basal and insulin-dependent glucose uptake of 3T3-L1 adipocytes, with dehydrosilybin showing significantly stronger inhibition.	Flavonoids	5-15	insulin	Cricetulus griseus	50-57
21275386-0	2011	Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	95-100
20537519-2	2011	To explore the possibility of delaying this decline using a dietary approach, we have examined the effect of a natural flavonoid, apigenin, on StAR gene expression in mouse Leydig cells.	Flavonoids	119-128	steroidogenic acute regulatory protein	Mus musculus	143-147
20537519-3	2011	Incubation of these cells with the flavonoid enhanced cyclic adenosine monophosphate (cAMP)-induced steroidogenesis and StAR protein expression.	Flavonoids	35-44	steroidogenic acute regulatory protein	Mus musculus	120-124
20537519-4	2011	The results from the analyses of StAR mRNA by reverse transcription-polymerase chain reaction and the luciferase assays of StAR promoter activity indicated that this flavonoid enhanced StAR gene expression at the level of transcription.	Flavonoids	166-175	steroidogenic acute regulatory protein	Mus musculus	33-37
20537519-4	2011	The results from the analyses of StAR mRNA by reverse transcription-polymerase chain reaction and the luciferase assays of StAR promoter activity indicated that this flavonoid enhanced StAR gene expression at the level of transcription.	Flavonoids	166-175	steroidogenic acute regulatory protein	Mus musculus	123-127
20537519-4	2011	The results from the analyses of StAR mRNA by reverse transcription-polymerase chain reaction and the luciferase assays of StAR promoter activity indicated that this flavonoid enhanced StAR gene expression at the level of transcription.	Flavonoids	166-175	steroidogenic acute regulatory protein	Mus musculus	123-127
21207142-6	2011	Our results indicate that the flavonoids and non-flavonoids tested exert their inhibitory effect on MMPs, displaying different mechanisms of action, possibly related to their structure.	Flavonoids	30-40	matrix metallopeptidase 2	Rattus norvegicus	100-104
21207142-6	2011	Our results indicate that the flavonoids and non-flavonoids tested exert their inhibitory effect on MMPs, displaying different mechanisms of action, possibly related to their structure.	Flavonoids	49-59	matrix metallopeptidase 2	Rattus norvegicus	100-104
21177254-3	2011	We hypothesize that a deficient DSB repair, as a result of an Atm mutation, may reinforce the clastogenic effect of dietary flavonoids and increase the frequency of Mll rearrangements.	Flavonoids	124-134	ataxia telangiectasia mutated	Mus musculus	62-65
21177254-7	2011	Prenatal exposure to flavonoids associated with higher frequencies of Mll rearrangements and a slight increase in the incidence of malignancies in DNA repair-deficient mice.	Flavonoids	21-31	lysine (K)-specific methyltransferase 2A	Mus musculus	70-73
21275386-3	2011	This activity was tracked throughout the extract fractionation process to a series of ABCG2 inhibitory flavonoids (1-13).	Flavonoids	103-113	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	86-91
21087598-0	2011	Eriodictyol: a flavonoid antagonist of the TRPV1 receptor with antioxidant activity.	Flavonoids	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
21345233-0	2011	Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.	Flavonoids	7-17	stearoyl-CoA desaturase	Rattus norvegicus	39-62
21345233-3	2011	Here, we show that citrus flavonoids of two structural classes reduce SCD1 mRNA concentrations in a dose-dependent manner in rat primary hepatocytes.	Flavonoids	26-36	stearoyl-CoA desaturase	Rattus norvegicus	70-74
21345233-4	2011	This is the first demonstration of repression of SCD1 by citrus flavonoids, either in vivo or in cultured cells.	Flavonoids	64-74	stearoyl-CoA desaturase	Rattus norvegicus	49-53
21345233-6	2011	This study demonstrates that regulation of SCD1 gene expression may play a role in control of obesity by citrus flavonoids and that rat primary hepatocytes are a physiologically-relevant model system for analyzing the molecular mechanisms of flavonoid action in the liver.	Flavonoids	112-122	stearoyl-CoA desaturase	Rattus norvegicus	43-47
21345233-6	2011	This study demonstrates that regulation of SCD1 gene expression may play a role in control of obesity by citrus flavonoids and that rat primary hepatocytes are a physiologically-relevant model system for analyzing the molecular mechanisms of flavonoid action in the liver.	Flavonoids	112-121	stearoyl-CoA desaturase	Rattus norvegicus	43-47
21087598-4	2011	The aim of this study was to investigate the possible interaction of the flavonoid eriodictyol with the TRPV1 receptor and to determine its putative antinociceptive and hyperthermic effects.	Flavonoids	73-82	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-109
21311414-6	2011	Before oral absorption, flavonoids undergo deglycosylation either by lactase phloridzin hydrolase or cytosolic beta-glucosidase.	Flavonoids	24-34	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	101-127
21311414-10	2011	Flavonoids of several classes are inhibitors of monoamine oxidase A or B, thereby working as anti-depressants or to improve the conditions of Parkinson"s patients.	Flavonoids	0-10	monoamine oxidase A	Homo sapiens	48-72
21235595-0	2011	Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9.	Flavonoids	62-72	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	76-82
21245867-0	2011	The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-kappaB.	Flavonoids	18-27	nuclear factor kappa B subunit 1	Homo sapiens	130-151
21235595-0	2011	Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9.	Flavonoids	62-72	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	87-93
21235595-1	2011	OBJECTIVES: This study tries to find structure-metabolism relationships between flavonoids and human UGT1A3 and UGT1A9.	Flavonoids	80-90	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	101-107
21075839-3	2011	We recently identified quercetin, a naturally occurring flavonoid, as a probe-dependent, pathway-selective allosteric modulator of GLP-1R-mediated signaling.	Flavonoids	56-65	glucagon like peptide 1 receptor	Homo sapiens	131-137
21235595-1	2011	OBJECTIVES: This study tries to find structure-metabolism relationships between flavonoids and human UGT1A3 and UGT1A9.	Flavonoids	80-90	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	112-118
21075839-4	2011	Using Chinese hamster ovary cells expressing the human GLP-1R, we have now extended this work to identify the structural requirements of flavonoids to modify GLP-1R binding and signaling (cAMP formation and intracellular Ca(2+) mobilization) of each of the GLP-1R endogenous agonists, as well as the clinically used exogenous peptide mimetic exendin-4.	Flavonoids	137-147	glucagon like peptide 1 receptor	Homo sapiens	55-61
21075839-4	2011	Using Chinese hamster ovary cells expressing the human GLP-1R, we have now extended this work to identify the structural requirements of flavonoids to modify GLP-1R binding and signaling (cAMP formation and intracellular Ca(2+) mobilization) of each of the GLP-1R endogenous agonists, as well as the clinically used exogenous peptide mimetic exendin-4.	Flavonoids	137-147	glucagon like peptide 1 receptor	Homo sapiens	158-164
21075839-4	2011	Using Chinese hamster ovary cells expressing the human GLP-1R, we have now extended this work to identify the structural requirements of flavonoids to modify GLP-1R binding and signaling (cAMP formation and intracellular Ca(2+) mobilization) of each of the GLP-1R endogenous agonists, as well as the clinically used exogenous peptide mimetic exendin-4.	Flavonoids	137-147	glucagon like peptide 1 receptor	Homo sapiens	158-164
21075839-8	2011	These data represent a detailed examination of the action of different flavonoids on peptide agonists at the GLP-1R and may aid in the development of future small molecule compounds targeted at this receptor.	Flavonoids	71-81	glucagon like peptide 1 receptor	Homo sapiens	109-115
21235595-2	2011	METHODS: The glucuronidation of flavonoids was studied with recombinant UGT1A3 and UGT1A9, and the glucuronidation activity was determined by HPLC.	Flavonoids	32-42	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	72-78
21235595-2	2011	METHODS: The glucuronidation of flavonoids was studied with recombinant UGT1A3 and UGT1A9, and the glucuronidation activity was determined by HPLC.	Flavonoids	32-42	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	83-89
21285919-2	2011	The aim of this study was to examine the significance of the intestinal hydrolysis of prenylated flavonoids by lactase phlorizin hydrolase (LPH), an enzyme at the brush border membrane of intestinal cells.	Flavonoids	97-107	lactase	Rattus norvegicus	111-138
20718051-0	2011	Molecular property-affinity relationship of flavanoids and flavonoids for HSA in vitro.	Flavonoids	59-69	albumin	Homo sapiens	74-77
20718051-1	2011	The relationship between the structural properties of selected dietary flavanoids and flavonoids and their affinities for HSA were investigated by fluorescence analysis.	Flavonoids	86-96	albumin	Homo sapiens	122-125
21285919-2	2011	The aim of this study was to examine the significance of the intestinal hydrolysis of prenylated flavonoids by lactase phlorizin hydrolase (LPH), an enzyme at the brush border membrane of intestinal cells.	Flavonoids	97-107	lactase	Rattus norvegicus	140-143
21285919-5	2011	A lactase phlorizin hydrolase inhibitor (gluconolactone) was employed to investigate the mechanism of the intestinal absorption, and the metabolites of the four flavonoids were identified using LC/MS/MS.	Flavonoids	161-171	lactase	Rattus norvegicus	2-29
21285919-9	2011	CONCLUSIONS: The results showed that lactase phlorizin hydrolase was a major determinant of the intestinal absorption of prenylated flavonoids present in Yinyanghuo.	Flavonoids	132-142	lactase	Rattus norvegicus	37-64
21067630-10	2011	Flavonoids from tea, soft fruits and soya are potent inhibitors of DNMT in vitro, capable of reversing hypermethylation and reactivating TS genes.	Flavonoids	0-10	DNA methyltransferase 1	Homo sapiens	67-71
21288453-7	2011	RESULTS: Compared with the control serum, Drynaria total flavonoids-containing serum promoted the proliferation and decreased the apoptosis of osteoblasts in TNF-alpha-mediated inflammatory environment (P&lt;0.05), and increased the ratio of Bcl-2 mRNA to Bax mRNA.	Flavonoids	57-67	tumor necrosis factor	Rattus norvegicus	158-167
21288453-7	2011	RESULTS: Compared with the control serum, Drynaria total flavonoids-containing serum promoted the proliferation and decreased the apoptosis of osteoblasts in TNF-alpha-mediated inflammatory environment (P&lt;0.05), and increased the ratio of Bcl-2 mRNA to Bax mRNA.	Flavonoids	57-67	BCL2, apoptosis regulator	Rattus norvegicus	242-247
21288453-1	2011	OBJECTIVE: To investigate the influence of Drynaria total flavonoids on proliferation and apoptosis of osteoblasts in tumor necrosis factor-alpha (TNF-alpha)- mediated medium, so as to explore the mechanism of Drynaria total flavonoids in preventing and treating osteoporosis of rheumatoid arthritis.	Flavonoids	58-68	tumor necrosis factor	Rattus norvegicus	147-156
21288453-7	2011	RESULTS: Compared with the control serum, Drynaria total flavonoids-containing serum promoted the proliferation and decreased the apoptosis of osteoblasts in TNF-alpha-mediated inflammatory environment (P&lt;0.05), and increased the ratio of Bcl-2 mRNA to Bax mRNA.	Flavonoids	57-67	BCL2 associated X, apoptosis regulator	Rattus norvegicus	256-259
21288453-8	2011	CONCLUSION: In TNF-alpha-mediated inflammatory environment, Drynaria total flavonoids can promote the proliferation and decrease the apoptosis of osteoblasts by improving the ratio of Bcl-2 mRNA to Bax mRNA, which may be one of the mechanisms of Drynaria total flavonoids in preventing and treating osteoporosis of rheumatoid arthritis.	Flavonoids	75-85	tumor necrosis factor	Rattus norvegicus	15-24
21288453-8	2011	CONCLUSION: In TNF-alpha-mediated inflammatory environment, Drynaria total flavonoids can promote the proliferation and decrease the apoptosis of osteoblasts by improving the ratio of Bcl-2 mRNA to Bax mRNA, which may be one of the mechanisms of Drynaria total flavonoids in preventing and treating osteoporosis of rheumatoid arthritis.	Flavonoids	75-85	BCL2, apoptosis regulator	Rattus norvegicus	184-189
21288453-8	2011	CONCLUSION: In TNF-alpha-mediated inflammatory environment, Drynaria total flavonoids can promote the proliferation and decrease the apoptosis of osteoblasts by improving the ratio of Bcl-2 mRNA to Bax mRNA, which may be one of the mechanisms of Drynaria total flavonoids in preventing and treating osteoporosis of rheumatoid arthritis.	Flavonoids	75-85	BCL2 associated X, apoptosis regulator	Rattus norvegicus	198-201
21288453-8	2011	CONCLUSION: In TNF-alpha-mediated inflammatory environment, Drynaria total flavonoids can promote the proliferation and decrease the apoptosis of osteoblasts by improving the ratio of Bcl-2 mRNA to Bax mRNA, which may be one of the mechanisms of Drynaria total flavonoids in preventing and treating osteoporosis of rheumatoid arthritis.	Flavonoids	261-271	BCL2, apoptosis regulator	Rattus norvegicus	184-189
21095188-7	2011	Further, JAK3 activity and chemotaxis were inhibited by the flavonoid apigenin (4",5,7-trihydroxyflavone) at ~5nM IC(50).	Flavonoids	60-69	Janus kinase 3	Homo sapiens	9-13
21074525-0	2011	Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.	Flavonoids	100-109	histone deacetylase 9	Homo sapiens	56-75
21219654-13	2011	Transcriptional patterns of MYB5A and MYB5B were similar during berry development between the two varieties, but those of MYBPA1 and MYBPA2 were strikingly different, demonstrating that the general flavonoid pathways are regulated under different MYB factors.	Flavonoids	198-207	MybPA2	Vitis vinifera	133-139
21747849-0	2011	Predicting Flavonoid UGT Regioselectivity.	Flavonoids	11-20	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	21-24
22187677-0	2011	Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1.	Flavonoids	45-55	ATP binding cassette subfamily B member 1	Homo sapiens	107-121
22187677-0	2011	Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1.	Flavonoids	45-55	ATP binding cassette subfamily C member 1	Homo sapiens	126-130
22187677-5	2011	In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed.	Flavonoids	83-93	ATP binding cassette subfamily B member 1	Homo sapiens	118-132
22187677-5	2011	In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed.	Flavonoids	83-93	ATP binding cassette subfamily C member 1	Homo sapiens	137-141
21738321-0	2011	Flavonoids lower Alzheimer"s Abeta production via an NFkappaB dependent mechanism.	Flavonoids	0-10	nuclear factor kappa B subunit 1	Homo sapiens	53-61
22255029-6	2011	We have compared two commonly used software, one of which takes into account solvation, on a set of small molecules (Morpholines, flavonoids and imidazoles) which are able to target the RAC1 protein--a cardiovascular target.	Flavonoids	130-140	Rac family small GTPase 1	Homo sapiens	186-190
21738321-12	2011	We found however a strong correlation between the inhibition of NFkappaB activation by flavonoids and their Abeta lowering properties suggesting that flavonoids inhibit Abeta production in whole cells via NFkappaB related mechanisms.	Flavonoids	87-97	nuclear factor kappa B subunit 1	Homo sapiens	64-72
21738321-12	2011	We found however a strong correlation between the inhibition of NFkappaB activation by flavonoids and their Abeta lowering properties suggesting that flavonoids inhibit Abeta production in whole cells via NFkappaB related mechanisms.	Flavonoids	87-97	nuclear factor kappa B subunit 1	Homo sapiens	205-213
21738321-12	2011	We found however a strong correlation between the inhibition of NFkappaB activation by flavonoids and their Abeta lowering properties suggesting that flavonoids inhibit Abeta production in whole cells via NFkappaB related mechanisms.	Flavonoids	150-160	nuclear factor kappa B subunit 1	Homo sapiens	64-72
21738321-12	2011	We found however a strong correlation between the inhibition of NFkappaB activation by flavonoids and their Abeta lowering properties suggesting that flavonoids inhibit Abeta production in whole cells via NFkappaB related mechanisms.	Flavonoids	150-160	nuclear factor kappa B subunit 1	Homo sapiens	205-213
21738321-13	2011	As NFkappaB has been shown to regulate BACE-1 expression, we show that NFkappaB lowering flavonoids inhibit BACE-1 transcription in human neuronal SH-SY5Y cells.	Flavonoids	89-99	nuclear factor kappa B subunit 1	Homo sapiens	3-11
21738321-3	2011	Recently, it was suggested that the Abeta lowering properties of flavonoids are mediated by a direct inhibition the beta-secretase (BACE-1) activity, the rate limiting enzyme responsible for the production of Abeta peptides.	Flavonoids	65-75	beta-secretase 1	Homo sapiens	132-138
21738321-13	2011	As NFkappaB has been shown to regulate BACE-1 expression, we show that NFkappaB lowering flavonoids inhibit BACE-1 transcription in human neuronal SH-SY5Y cells.	Flavonoids	89-99	beta-secretase 1	Homo sapiens	39-45
21738321-13	2011	As NFkappaB has been shown to regulate BACE-1 expression, we show that NFkappaB lowering flavonoids inhibit BACE-1 transcription in human neuronal SH-SY5Y cells.	Flavonoids	89-99	nuclear factor kappa B subunit 1	Homo sapiens	71-79
21738321-5	2011	A cell free chemoluminescent assay using human recombinant BACE-1 was used to assess the effect of flavonoids on BACE-1 activity.	Flavonoids	99-109	beta-secretase 1	Homo sapiens	113-119
21738321-13	2011	As NFkappaB has been shown to regulate BACE-1 expression, we show that NFkappaB lowering flavonoids inhibit BACE-1 transcription in human neuronal SH-SY5Y cells.	Flavonoids	89-99	beta-secretase 1	Homo sapiens	108-114
21738321-14	2011	Altogether, our data suggest that flavonoids inhibit Abeta and sAPPbeta production by regulating BACE-1 expression and not by directly inhibiting BACE-1 activity.	Flavonoids	34-44	beta-secretase 1	Homo sapiens	97-103
21738321-6	2011	The effect of flavonoids on NFkappaB activation was determined by using a stable NFkappaB luciferase reporter cell line.	Flavonoids	14-24	nuclear factor kappa B subunit 1	Homo sapiens	28-36
21738321-6	2011	The effect of flavonoids on NFkappaB activation was determined by using a stable NFkappaB luciferase reporter cell line.	Flavonoids	14-24	nuclear factor kappa B subunit 1	Homo sapiens	81-89
21738321-7	2011	Molecular docking simulations were performed to predict the binding of flavonoids to the BACE-1 catalytic site.	Flavonoids	71-81	beta-secretase 1	Homo sapiens	89-95
21738321-8	2011	Real time quantitative PCR was used to determine the effect of flavonoids on BACE-1 transcription.	Flavonoids	63-73	beta-secretase 1	Homo sapiens	77-83
21738321-9	2011	We show in a cell free assay that flavonoids are only weak inhibitors of BACE-1 activity.	Flavonoids	34-44	beta-secretase 1	Homo sapiens	73-79
21738321-10	2011	Docking simulation studies with different BACE-1 structures also suggest that flavonoids are poor BACE-1 inhibitors as they appear to adopt various docking poses in the active site pocket and have weak docking scores that differ as a function of the BACE-1 structures studied.	Flavonoids	78-88	beta-secretase 1	Homo sapiens	42-48
21738321-10	2011	Docking simulation studies with different BACE-1 structures also suggest that flavonoids are poor BACE-1 inhibitors as they appear to adopt various docking poses in the active site pocket and have weak docking scores that differ as a function of the BACE-1 structures studied.	Flavonoids	78-88	beta-secretase 1	Homo sapiens	98-104
21738321-10	2011	Docking simulation studies with different BACE-1 structures also suggest that flavonoids are poor BACE-1 inhibitors as they appear to adopt various docking poses in the active site pocket and have weak docking scores that differ as a function of the BACE-1 structures studied.	Flavonoids	78-88	beta-secretase 1	Homo sapiens	98-104
21738321-11	2011	Moreover, a weak correlation was observed between the effect of flavonoids on Abeta production in vitro and their ability to lower BACE-1 activity suggesting that the Abeta lowering properties of flavonoids in whole cells are not mediated via direct inhibition of BACE-1 activity.	Flavonoids	64-74	beta-secretase 1	Homo sapiens	131-137
21568900-4	2011	In addition to their antioxidative activity, many flavonoids were demonstrated to act on biological targets involved in type 2 diabetes mellitus such as: alpha-glycosidase, glucose cotransporter or aldose reductase.	Flavonoids	50-60	aldo-keto reductase family 1 member B	Homo sapiens	198-214
21821919-1	2011	The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins.	Flavonoids	128-138	CXADR pseudogene 1	Homo sapiens	37-40
21129983-0	2011	Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.	Flavonoids	23-33	calmodulin 1	Homo sapiens	42-52
21865857-3	2011	In the present report, we investigated the effect of quercetin, a flavonoid, on NGF-induced neurite outgrowth in PC12 cells (the parental strain of PC12D cells).	Flavonoids	66-75	nerve growth factor	Rattus norvegicus	80-83
21865857-5	2011	Knockdown of NKCC1 by RNAi methods abolished the stimulatory effect of flavonoid.	Flavonoids	71-80	solute carrier family 12 member 2	Rattus norvegicus	13-18
22130376-3	2011	The two new flavanones and some known flavonoids showed the inhibitory activity on the release of beta-hexosaminidase from RBL-2H3 cells.	Flavonoids	38-48	O-GlcNAcase	Rattus norvegicus	98-117
22130376-3	2011	The two new flavanones and some known flavonoids showed the inhibitory activity on the release of beta-hexosaminidase from RBL-2H3 cells.	Flavonoids	38-48	RB transcriptional corepressor like 2	Rattus norvegicus	123-128
21728961-5	2011	Interestingly, inhibitory flavonoids are quite specific for ABCG2 versus ABCB1 and ABCC1, and appear either non-competitive or partially competitive towards mitoxantrone efflux.	Flavonoids	26-36	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	60-65
21728961-5	2011	Interestingly, inhibitory flavonoids are quite specific for ABCG2 versus ABCB1 and ABCC1, and appear either non-competitive or partially competitive towards mitoxantrone efflux.	Flavonoids	26-36	ATP binding cassette subfamily B member 1	Homo sapiens	73-78
21625419-0	2011	Flavonoids targeting of IkappaB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells.	Flavonoids	0-10	matrix metallopeptidase 9	Homo sapiens	77-82
21728961-5	2011	Interestingly, inhibitory flavonoids are quite specific for ABCG2 versus ABCB1 and ABCC1, and appear either non-competitive or partially competitive towards mitoxantrone efflux.	Flavonoids	26-36	ATP binding cassette subfamily C member 1	Homo sapiens	83-88
22087826-0	2011	Flavonoids as acetylcholinesterase inhibitors.	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
22087826-3	2011	Flavonoids with AChE inhibitory activity and due to their well known antioxidant activity could be new multipotent drugs for AD treatment.	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-20
22087826-4	2011	This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE).	Flavonoids	43-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99
22087826-4	2011	This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE).	Flavonoids	43-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
21691069-5	2011	Inhibition of p38 MAPK activity by SB202190, or over-expression of dominant-negative mutant form of p38 MAPK resulted in suppression of cytoprotective effect of the flavonoid.	Flavonoids	165-174	mitogen-activated protein kinase 14	Homo sapiens	14-17
21691069-5	2011	Inhibition of p38 MAPK activity by SB202190, or over-expression of dominant-negative mutant form of p38 MAPK resulted in suppression of cytoprotective effect of the flavonoid.	Flavonoids	165-174	mitogen-activated protein kinase 14	Homo sapiens	100-103
21625419-8	2011	Our results suggest that BBB disruption during neuroinflammation could be pharmacologically reduced by a specific class of flavonoids acting as NF-kappaB signal transduction inhibitors.	Flavonoids	123-133	nuclear factor kappa B subunit 1	Homo sapiens	144-153
21625419-0	2011	Flavonoids targeting of IkappaB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
21625419-4	2011	In this study, we sought to investigate the nuclear factor-kappa B (NF-kappaB) signaling pathway, a common pathway in both the regulation of matrix metalloproteinase-9 (MMP-9) and COX-2 expression, and the inhibitory properties of several chemopreventive flavonoids.	Flavonoids	255-265	nuclear factor kappa B subunit 1	Homo sapiens	44-66
21625419-4	2011	In this study, we sought to investigate the nuclear factor-kappa B (NF-kappaB) signaling pathway, a common pathway in both the regulation of matrix metalloproteinase-9 (MMP-9) and COX-2 expression, and the inhibitory properties of several chemopreventive flavonoids.	Flavonoids	255-265	nuclear factor kappa B subunit 1	Homo sapiens	68-77
21731475-2	2011	Chromatin immunoprecipitation (ChIP) studies revealed that luteolin modified histone H4 acetylation at the PLK-1 promoter suggesting that this bioflavonoid controls gene transcription via an epigenetic mechanism involving histone H4 acetylation.	Flavonoids	143-155	polo like kinase 1	Homo sapiens	107-112
21791871-0	2011	Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.	Flavonoids	66-75	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	14-33
21791871-1	2011	The aim of this study was to assess the effects of diosmetin and hesperetin, two flavonoids present in various medicinal products, on CYP2C8 activity of human liver microsomes using paclitaxel oxidation to 6alpha-hydroxy-paclitaxel as a probe reaction.	Flavonoids	81-91	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	134-140
21791871-4	2011	This flavonoid proved to be a reversible, dead-end, full inhibitor of CYP2C8, its mean inhibition constant (K(i)) being 3.13 +- 0.11 microM.	Flavonoids	5-14	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	70-76
21112745-0	2011	The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells.	Flavonoids	4-14	matrix metallopeptidase 1	Homo sapiens	68-94
21977025-2	2011	Flavanone 3-hydroxylase (F3H) is a key enzyme at a diverging point of the flavonoid pathway leading to production of different pigments: phlobaphene, proanthocyanidin, and anthocyanin.	Flavonoids	74-83	flavanone 3-dioxygenase 2	Triticum aestivum	0-23
21977025-2	2011	Flavanone 3-hydroxylase (F3H) is a key enzyme at a diverging point of the flavonoid pathway leading to production of different pigments: phlobaphene, proanthocyanidin, and anthocyanin.	Flavonoids	74-83	flavanone 3-dioxygenase 2	Triticum aestivum	25-28
21753864-5	2011	Modification of cell death signaling after stress-induced apoptosis and necrosis by flavonoids was assessed using caspase-3 and calpain immunoreactivity assays.	Flavonoids	84-94	caspase 3	Rattus norvegicus	114-123
21606625-0	2011	Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1beta-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.	Flavonoids	11-21	matrix metallopeptidase 13	Homo sapiens	25-52
21606625-0	2011	Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1beta-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.	Flavonoids	11-21	interleukin 1 beta	Homo sapiens	67-84
21606625-0	2011	Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1beta-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.	Flavonoids	11-21	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	161-166
21606625-0	2011	Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1beta-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.	Flavonoids	11-21	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
21606625-0	2011	Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1beta-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.	Flavonoids	11-21	signal transducer and activator of transcription 1	Homo sapiens	180-184
21606625-1	2011	To identify the therapeutic potential for cartilage degradation and its action mechanisms, the effects of naturally-occurring flavonoids on matrix metalloproteinase-13 (MMP-13) induction were examined in the human chondrocyte cell line SW1353.	Flavonoids	126-136	matrix metallopeptidase 13	Homo sapiens	140-167
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavonoids	52-62	matrix metallopeptidase 13	Homo sapiens	93-99
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavonoids	52-62	interleukin 1 beta	Homo sapiens	114-122
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavonoids	52-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavonoids	52-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	188-192
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavonoids	52-62	Janus kinase 2	Homo sapiens	197-201
21606625-7	2011	Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1beta-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.	Flavonoids	52-62	signal transducer and activator of transcription 1	Homo sapiens	202-209
20467782-5	2011	The SocL extract as well as the constituent flavonoid wogonin also showed dose- and time-dependent inhibition of Akt, GSK-3alpha/beta and NF-kappaB in F98 cell cultures in vitro, as determined by western blot analysis.	Flavonoids	44-53	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
20467782-5	2011	The SocL extract as well as the constituent flavonoid wogonin also showed dose- and time-dependent inhibition of Akt, GSK-3alpha/beta and NF-kappaB in F98 cell cultures in vitro, as determined by western blot analysis.	Flavonoids	44-53	glycogen synthase kinase 3 alpha	Rattus norvegicus	118-128
22096315-6	2011	Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants.	Flavonoids	70-80	sucrase-isomaltase	Homo sapiens	5-22
22167217-4	2011	Here, the effect of CYP1A1/2 induction due to their prototype flavonoid inducer, beta-naphthoflavone (BNF), on BaP- and PhPI-derived DNA adduct formation in rats was examined.	Flavonoids	62-71	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	20-26
22167217-14	2011	CONCLUSIONS: The results of this study demonstrate that the administration of only a single dose of CYP-inducing flavonoid prior to the intake of food carcinogens may increase the risk of a tumor formation.	Flavonoids	113-122	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	100-103
21462089-0	2011	Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions.	Flavonoids	105-114	dynein axonemal heavy chain 8	Homo sapiens	86-92
21462089-8	2011	These effects correlated with the effects of flavonoids on P-gp-ATPase activity.	Flavonoids	45-55	dynein axonemal heavy chain 8	Homo sapiens	64-70
21462089-9	2011	Flavonoids that decreased DNR accumulation stimulated DNR-activated P-gp ATPase, whereas flavonoids that increased fluorescently labeled VLB accumulation inhibited VBL-stimulated P-gp ATPase activity, thereby accounting for the decrease or increase in cancer drug accumulation in resistant cells.	Flavonoids	0-10	dynein axonemal heavy chain 8	Homo sapiens	73-79
21462089-9	2011	Flavonoids that decreased DNR accumulation stimulated DNR-activated P-gp ATPase, whereas flavonoids that increased fluorescently labeled VLB accumulation inhibited VBL-stimulated P-gp ATPase activity, thereby accounting for the decrease or increase in cancer drug accumulation in resistant cells.	Flavonoids	89-99	dynein axonemal heavy chain 8	Homo sapiens	184-190
22145036-6	2011	Flavonol synthase (FLS) is an important enzyme of flavonoid pathway that catalyzes the formation of flavonols.	Flavonoids	50-59	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	0-17
22145036-6	2011	Flavonol synthase (FLS) is an important enzyme of flavonoid pathway that catalyzes the formation of flavonols.	Flavonoids	50-59	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	19-22
21053930-0	2010	Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.	Flavonoids	107-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-91
21311134-1	2011	OBJECTIVE: To explore the effect of total flavonoids of Epimedium sagittatum (TFE) on the mRNA expressions of the estrogen receptor alpha (ERalpha) and estrogen receptor beta(ERbeta) in hippocampus and hypothalamus in ovariectomized (OVX) Sprague-Dawley(SD) rats, and the mechanism of TFE against postmenopausal osteoporosis.	Flavonoids	42-52	estrogen receptor 1	Rattus norvegicus	139-146
21311134-1	2011	OBJECTIVE: To explore the effect of total flavonoids of Epimedium sagittatum (TFE) on the mRNA expressions of the estrogen receptor alpha (ERalpha) and estrogen receptor beta(ERbeta) in hippocampus and hypothalamus in ovariectomized (OVX) Sprague-Dawley(SD) rats, and the mechanism of TFE against postmenopausal osteoporosis.	Flavonoids	42-52	estrogen receptor 2	Rattus norvegicus	175-181
21105652-7	2010	Major compounds found in the bioactive fraction CSF2+3 are flavonoids, indoles, and phenolic acids.	Flavonoids	59-69	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	48-52
21053930-1	2010	Structure-function relationships for the inhibition of human cytochrome P450s (P450s) 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives were studied.	Flavonoids	120-129	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	61-104
21053930-2	2010	Thirty-two of the 33 flavonoids tested produced reverse type I binding spectra with P450 1B1, and the potencies of binding were correlated with the abilities to inhibit 7-ethoxyresorufin O-deethylation activity.	Flavonoids	21-31	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	84-92
20840863-0	2010	Inhibition of liver X receptor-alpha-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition.	Flavonoids	110-119	nuclear receptor subfamily 1, group H, member 3	Mus musculus	14-36
20854805-7	2010	We found that several flavonoids can markedly block NSC-741909-induced apoptosis and JNK activation in a time-dependent manner, regardless of whether they inhibit MEK or not.	Flavonoids	22-32	mitogen-activated protein kinase 8	Homo sapiens	85-88
20854805-9	2010	Our results also showed that NSC-741909 induced a dramatic increase of reactive oxygen species in sensitive cells and that flavonoids effectively blocked the NSC-741909-induced reactive oxygen species production which are associated with flavonoids" antagonistic effects on NSC-741909-induced JNK activation and apoptosis.	Flavonoids	123-133	mitogen-activated protein kinase 8	Homo sapiens	293-296
20854805-9	2010	Our results also showed that NSC-741909 induced a dramatic increase of reactive oxygen species in sensitive cells and that flavonoids effectively blocked the NSC-741909-induced reactive oxygen species production which are associated with flavonoids" antagonistic effects on NSC-741909-induced JNK activation and apoptosis.	Flavonoids	238-248	mitogen-activated protein kinase 8	Homo sapiens	293-296
20858478-0	2010	The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition.	Flavonoids	4-13	tumor protein p53	Homo sapiens	132-135
20858478-0	2010	The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition.	Flavonoids	4-13	nuclear factor kappa B subunit 1	Homo sapiens	150-159
21108268-0	2010	Biological evaluation and structural determinants of p38alpha mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.	Flavonoids	139-149	mitogen-activated protein kinase 14	Homo sapiens	53-61
21108268-0	2010	Biological evaluation and structural determinants of p38alpha mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.	Flavonoids	139-149	mitogen-activated protein kinase 10	Homo sapiens	99-124
21108268-1	2010	A series of 42 naturally occurring flavonoids and one flavonoid glucuronide were tested for their ability to inhibit p38alpha mitogen-activated protein kinase (p38alpha) and c-Jun-N-terminal kinase 3 (JNK3).	Flavonoids	35-45	mitogen-activated protein kinase 14	Homo sapiens	117-125
21108268-1	2010	A series of 42 naturally occurring flavonoids and one flavonoid glucuronide were tested for their ability to inhibit p38alpha mitogen-activated protein kinase (p38alpha) and c-Jun-N-terminal kinase 3 (JNK3).	Flavonoids	35-45	mitogen-activated protein kinase 14	Homo sapiens	126-168
21108268-1	2010	A series of 42 naturally occurring flavonoids and one flavonoid glucuronide were tested for their ability to inhibit p38alpha mitogen-activated protein kinase (p38alpha) and c-Jun-N-terminal kinase 3 (JNK3).	Flavonoids	35-45	mitogen-activated protein kinase 10	Homo sapiens	174-199
21108268-1	2010	A series of 42 naturally occurring flavonoids and one flavonoid glucuronide were tested for their ability to inhibit p38alpha mitogen-activated protein kinase (p38alpha) and c-Jun-N-terminal kinase 3 (JNK3).	Flavonoids	35-45	mitogen-activated protein kinase 10	Homo sapiens	201-205
21108268-4	2010	Among the different classes of flavonoids, the flavonol group showed better inhibition of p38alpha.	Flavonoids	31-41	mitogen-activated protein kinase 14	Homo sapiens	90-98
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Flavonoids	25-35	solute carrier organic anion transporter family member 1A2	Homo sapiens	240-247
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Flavonoids	25-35	solute carrier organic anion transporter family member 2B1	Homo sapiens	258-265
20797388-4	2010	However, the impact of flavonoids on OATP1A2 and OATP2B1 transport function has not been analyzed in detail.	Flavonoids	23-33	solute carrier organic anion transporter family member 1A2	Homo sapiens	37-44
20797388-4	2010	However, the impact of flavonoids on OATP1A2 and OATP2B1 transport function has not been analyzed in detail.	Flavonoids	23-33	solute carrier organic anion transporter family member 2B1	Homo sapiens	49-56
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Flavonoids	25-35	solute carrier organic anion transporter family member 1A2	Homo sapiens	177-184
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Flavonoids	25-35	solute carrier organic anion transporter family member 2B1	Homo sapiens	199-206
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Flavonoids	25-35	solute carrier organic anion transporter family member 1A2	Homo sapiens	240-247
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Flavonoids	25-35	solute carrier organic anion transporter family member 2B1	Homo sapiens	258-265
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Flavonoids	25-35	latexin	Homo sapiens	190-193
20840863-0	2010	Inhibition of liver X receptor-alpha-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition.	Flavonoids	110-119	mitogen-activated protein kinase 8	Mus musculus	136-140
20444210-0	2010	A new dominant Arabidopsis transparent testa mutant, sk21-D, and modulation of seed flavonoid biosynthesis by KAN4.	Flavonoids	84-93	Homeodomain-like superfamily protein	Arabidopsis thaliana	110-114
20731781-1	2010	The flavonol branch of flavonoid biosynthesis is under transcriptional control of the R2R3-MYBs production of flavonol glycoside1 (PFG1/MYB12, PFG2/MYB11 and PFG3/MYB111) in Arabidopsis thaliana.	Flavonoids	23-32	myb domain protein 12	Arabidopsis thaliana	131-135
20731781-1	2010	The flavonol branch of flavonoid biosynthesis is under transcriptional control of the R2R3-MYBs production of flavonol glycoside1 (PFG1/MYB12, PFG2/MYB11 and PFG3/MYB111) in Arabidopsis thaliana.	Flavonoids	23-32	myb domain protein 12	Arabidopsis thaliana	136-141
20731781-1	2010	The flavonol branch of flavonoid biosynthesis is under transcriptional control of the R2R3-MYBs production of flavonol glycoside1 (PFG1/MYB12, PFG2/MYB11 and PFG3/MYB111) in Arabidopsis thaliana.	Flavonoids	23-32	myb domain protein 11	Arabidopsis thaliana	143-147
20731781-1	2010	The flavonol branch of flavonoid biosynthesis is under transcriptional control of the R2R3-MYBs production of flavonol glycoside1 (PFG1/MYB12, PFG2/MYB11 and PFG3/MYB111) in Arabidopsis thaliana.	Flavonoids	23-32	myb domain protein 11	Arabidopsis thaliana	148-153
20731781-1	2010	The flavonol branch of flavonoid biosynthesis is under transcriptional control of the R2R3-MYBs production of flavonol glycoside1 (PFG1/MYB12, PFG2/MYB11 and PFG3/MYB111) in Arabidopsis thaliana.	Flavonoids	23-32	myb domain protein 111	Arabidopsis thaliana	158-162
20731781-1	2010	The flavonol branch of flavonoid biosynthesis is under transcriptional control of the R2R3-MYBs production of flavonol glycoside1 (PFG1/MYB12, PFG2/MYB11 and PFG3/MYB111) in Arabidopsis thaliana.	Flavonoids	23-32	myb domain protein 111	Arabidopsis thaliana	163-169
20826149-4	2010	This study examined the potential suppressive effect of the flavonoid on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the non-tumorigenic MCF-10A and cancerous MCF-7 breast cells.	Flavonoids	60-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20444210-6	2010	KAN4 was localized to the nucleus and could specifically bind with promoters of early and late flavonoid biosynthetic genes and PA regulatory genes.	Flavonoids	95-104	Homeodomain-like superfamily protein	Arabidopsis thaliana	0-4
20444210-9	2010	Flavonoid and proanthocyanidin contents and transcript amounts for genes involved in flavonoid biosynthesis also were reduced in KAN4 activation lines.	Flavonoids	0-9	Homeodomain-like superfamily protein	Arabidopsis thaliana	129-133
20444210-4	2010	In this report, KAN4 is shown to broadly control the flavonoid pathway in Arabidopsis seed.	Flavonoids	53-62	Homeodomain-like superfamily protein	Arabidopsis thaliana	16-20
20444210-9	2010	Flavonoid and proanthocyanidin contents and transcript amounts for genes involved in flavonoid biosynthesis also were reduced in KAN4 activation lines.	Flavonoids	85-94	Homeodomain-like superfamily protein	Arabidopsis thaliana	129-133
20440299-9	2010	The resulting lower MPO release in the injured tissue is likely to decrease the extent of secondary injury and might at least partially explain the neuroprotective effect of the flavonoid quercetin.	Flavonoids	178-187	myeloperoxidase	Rattus norvegicus	20-23
21045071-7	2010	The genes positively controlled by FUS3 are not confined to previously known seed maturation-related genes and include those involved in the production of secondary metabolites, such as glucosinolates, phenylpropanoids and flavonoids, and those involved in primary metabolism, such as photosynthesis and fatty acid biosynthesis.	Flavonoids	223-233	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	35-39
20042712-0	2010	Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of DeltaF508 cystic fibrosis transmembrane conductance regulator rescue.	Flavonoids	77-86	CF transmembrane conductance regulator	Homo sapiens	18-69
20951593-9	2010	A selection of representative flavonoid inhibitors indicated that although they also inhibit the homologous human CD38, a selectivity in favor of SmNACE could be reached.	Flavonoids	30-39	CD38 molecule	Homo sapiens	114-118
20042712-4	2010	A screen of flavonoids in CFBE41o- cells stably transduced with DeltaF508 CFTR, corrected to the cell surface with low temperature growth, revealed that quercetin stimulated an increase in the short-circuit current.	Flavonoids	12-22	CF transmembrane conductance regulator	Homo sapiens	74-78
20807862-8	2010	Since MYB75 physically interacts with another secondary cell wall regulator, the KNOX transcription factor KNAT7, these regulatory proteins may form functional complexes that contribute to the regulation of secondary cell wall deposition in the Arabidopsis inflorescence stem and that integrate the metabolic flux through the lignin, flavonoid, and polysaccharide pathways.	Flavonoids	334-343	production of anthocyanin pigment 1	Arabidopsis thaliana	6-11
21048354-1	2010	In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2"",3"":7,8)-furanoflavanone (1), along with six known flavonoids (2-7).	Flavonoids	337-347	TNF superfamily member 10	Homo sapiens	116-121
20458747-7	2010	Application of flavonoids to prevent the migration/invasion of glioblastoma cells through blocking PKCalpha/ERK/NF-kappaB activation is first demonstrated herein.	Flavonoids	15-25	protein kinase C alpha	Homo sapiens	99-107
20458747-7	2010	Application of flavonoids to prevent the migration/invasion of glioblastoma cells through blocking PKCalpha/ERK/NF-kappaB activation is first demonstrated herein.	Flavonoids	15-25	mitogen-activated protein kinase 1	Homo sapiens	108-111
20458747-7	2010	Application of flavonoids to prevent the migration/invasion of glioblastoma cells through blocking PKCalpha/ERK/NF-kappaB activation is first demonstrated herein.	Flavonoids	15-25	nuclear factor kappa B subunit 1	Homo sapiens	112-121
20863730-0	2010	3D-QSAR (CoMFA and CoMSIA) and pharmacophore (GALAHAD) studies on the differential inhibition of aldose reductase by flavonoid compounds.	Flavonoids	117-126	aldo-keto reductase family 1 member B	Homo sapiens	97-113
20863730-1	2010	Inhibitory activities of flavonoid derivatives against aldose reductase (AR) enzyme were modelled by using CoMFA, CoMSIA and GALAHAD methods.	Flavonoids	25-34	aldo-keto reductase family 1 member B	Homo sapiens	55-71
20863730-1	2010	Inhibitory activities of flavonoid derivatives against aldose reductase (AR) enzyme were modelled by using CoMFA, CoMSIA and GALAHAD methods.	Flavonoids	25-34	aldo-keto reductase family 1 member B	Homo sapiens	73-75
19608276-3	2010	Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1).	Flavonoids	84-93	aryl hydrocarbon receptor	Homo sapiens	177-180
19608276-3	2010	Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1).	Flavonoids	84-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	197-216
19608276-3	2010	Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1).	Flavonoids	84-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	218-224
20732377-5	2010	The most vulnerable targets of the flavonoids were the secretion of cortisol and testosterone, which were inhibited by daidzein and genistein with IC50 values below 1 muM.	Flavonoids	35-45	latexin	Homo sapiens	167-170
20804812-3	2010	Among six flavonoids tested in the current study, VEGF gene transcription in MCF-7 cells with stable Pin1 overexpression was inhibited most effectively by quercetin.	Flavonoids	10-20	vascular endothelial growth factor A	Homo sapiens	50-54
20804812-3	2010	Among six flavonoids tested in the current study, VEGF gene transcription in MCF-7 cells with stable Pin1 overexpression was inhibited most effectively by quercetin.	Flavonoids	10-20	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	101-105
20807862-8	2010	Since MYB75 physically interacts with another secondary cell wall regulator, the KNOX transcription factor KNAT7, these regulatory proteins may form functional complexes that contribute to the regulation of secondary cell wall deposition in the Arabidopsis inflorescence stem and that integrate the metabolic flux through the lignin, flavonoid, and polysaccharide pathways.	Flavonoids	334-343	homeobox knotted-like protein	Arabidopsis thaliana	107-112
20843083-0	2010	On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme.	Flavonoids	43-53	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	69-109
20012048-0	2010	Dietary flavonoid apigenin inhibits endothelin-1-induced contraction of collagen gel.	Flavonoids	8-17	endothelin 1	Homo sapiens	36-48
20828797-0	2010	A series of natural flavonoids as thrombin inhibitors: structure-activity relationships.	Flavonoids	20-30	coagulation factor II, thrombin	Homo sapiens	34-42
20828797-1	2010	A series of natural flavonoids has been evaluated as potential inhibitors of thrombin using the optimized method of thrombin time.	Flavonoids	20-30	coagulation factor II, thrombin	Homo sapiens	77-85
20828797-4	2010	Structure-activity relationships of flavonoids (SARs) on thrombin would facilitate the design of chemical compounds with higher potency to serve as potential thrombin inhibitors, and provide information for the exploitation and utilization of flavonoids as thrombin inhibitors for thrombotic disease treatment.	Flavonoids	36-46	coagulation factor II, thrombin	Homo sapiens	57-65
20828797-4	2010	Structure-activity relationships of flavonoids (SARs) on thrombin would facilitate the design of chemical compounds with higher potency to serve as potential thrombin inhibitors, and provide information for the exploitation and utilization of flavonoids as thrombin inhibitors for thrombotic disease treatment.	Flavonoids	36-46	coagulation factor II, thrombin	Homo sapiens	158-166
20828797-4	2010	Structure-activity relationships of flavonoids (SARs) on thrombin would facilitate the design of chemical compounds with higher potency to serve as potential thrombin inhibitors, and provide information for the exploitation and utilization of flavonoids as thrombin inhibitors for thrombotic disease treatment.	Flavonoids	36-46	coagulation factor II, thrombin	Homo sapiens	158-166
20828797-4	2010	Structure-activity relationships of flavonoids (SARs) on thrombin would facilitate the design of chemical compounds with higher potency to serve as potential thrombin inhibitors, and provide information for the exploitation and utilization of flavonoids as thrombin inhibitors for thrombotic disease treatment.	Flavonoids	243-253	coagulation factor II, thrombin	Homo sapiens	57-65
20655989-3	2010	Pilot studies show a flavonoid-induced modulation of intracellular mitogen-activated protein kinases (MAPK) as p38 and interactions with voltage activated potassium channel currents (I(K(V))).	Flavonoids	21-30	mitogen activated protein kinase 14	Rattus norvegicus	111-114
20843083-0	2010	On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme.	Flavonoids	43-53	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	111-115
20843083-1	2010	Density functional theory was applied to study the binding mode of new flavonoids as possible inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), an enzyme that catalyzes the four-electron reduction of HMGCoA to mevalonate, the committed step in the biosynthesis of sterols.	Flavonoids	71-81	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	112-152
20843083-1	2010	Density functional theory was applied to study the binding mode of new flavonoids as possible inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), an enzyme that catalyzes the four-electron reduction of HMGCoA to mevalonate, the committed step in the biosynthesis of sterols.	Flavonoids	71-81	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	154-158
20843083-2	2010	The investigated flavonoid conjugates brutieridin and melitidin were recently quantified in the bergamot fruit extracts and identified to be structural analogues of statins, lipids concentration lowering drugs that inhibit HMGR.	Flavonoids	17-26	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	223-227
20845002-1	2010	INTRODUCTION: Flavocoxid is a novel flavonoid-based "dual inhibitor" of the 5-lipoxygenase (5-LOX) enzyme and the cyclooxygenase (COX) enzymes.	Flavonoids	36-45	arachidonate 5-lipoxygenase	Homo sapiens	76-90
20619256-0	2010	Inhibitory effect of quercetin on matrix metalloproteinase 9 activity molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction.	Flavonoids	133-142	matrix metallopeptidase 9	Homo sapiens	34-60
20619256-3	2010	Even though the relationship between flavonoid chemical structure and the inhibitory property on MMP activity has been established, the molecular mechanisms of this inhibition are still unknown.	Flavonoids	37-46	matrix metallopeptidase 9	Homo sapiens	97-100
20619256-4	2010	Herein, we first evaluated the inhibitory effect of quercetin on MMP-9 activity by zymography and a fluorescent gelatin dequenching assay, secondly we determined the most probable sites and modes of quercetin interaction with the MMP-9 catalytic domain by using molecular modelling techniques, and finally, we investigated the structure-activity relationship of the inhibitory effect of flavonoids on MMP-9 activity.	Flavonoids	387-397	matrix metallopeptidase 9	Homo sapiens	230-235
20619256-4	2010	Herein, we first evaluated the inhibitory effect of quercetin on MMP-9 activity by zymography and a fluorescent gelatin dequenching assay, secondly we determined the most probable sites and modes of quercetin interaction with the MMP-9 catalytic domain by using molecular modelling techniques, and finally, we investigated the structure-activity relationship of the inhibitory effect of flavonoids on MMP-9 activity.	Flavonoids	387-397	matrix metallopeptidase 9	Homo sapiens	230-235
20619256-8	2010	In conclusion, our data constitute the first evidence about the quercetin and MMP-9 interaction, suggesting a mechanism to explain the inhibitory effect of the flavonoid on the enzymatic activity of MMP-9, which provides an additional molecular target for the cardioprotective activity of quercetin.	Flavonoids	160-169	matrix metallopeptidase 9	Homo sapiens	78-83
20619256-8	2010	In conclusion, our data constitute the first evidence about the quercetin and MMP-9 interaction, suggesting a mechanism to explain the inhibitory effect of the flavonoid on the enzymatic activity of MMP-9, which provides an additional molecular target for the cardioprotective activity of quercetin.	Flavonoids	160-169	matrix metallopeptidase 9	Homo sapiens	199-204
20633549-3	2010	Functional test based on the transport of fluorescent substrate BCECF revealed that the flavonoid strongly inhibited MRP1 transport activity in human erythrocytes (IC(50)=5.76+/-1.80muM).	Flavonoids	88-97	ATP binding cassette subfamily C member 1	Homo sapiens	117-121
20929528-10	2010	Results from ATH1 microarray and qPCR experiments revealed a shift in gene activity from general flavonoid biosynthesis at early stages of seed development to PA synthesis at late (mature) stages of embryogenesis.	Flavonoids	97-106	homeobox protein ATH1	Arabidopsis thaliana	13-17
20845002-1	2010	INTRODUCTION: Flavocoxid is a novel flavonoid-based "dual inhibitor" of the 5-lipoxygenase (5-LOX) enzyme and the cyclooxygenase (COX) enzymes.	Flavonoids	36-45	arachidonate 5-lipoxygenase	Homo sapiens	92-97
20878708-4	2010	The flavonoids were isolated from SPB and their chemical structures were identified as chrysoeriol (1), apigenin (2), luteolin (3), vitexin (4), cosmosin (5), orientin (6) and luteolin-7-O-beta-d-glucoside (7) by spectroscopic analysis.	Flavonoids	4-14	surfactant associated protein B	Mus musculus	34-37
20691240-0	2010	The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.	Flavonoids	12-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20691749-3	2010	Total phenolic content found in methanol extracts of SM1-SM5 ranged from 739.36 +- 1.59 to 1116.13 +- 7.30 gallic acid equivalents mg/100g extract and total flavonoid content from 1991.29 +- 6.32 to 3954.20 +- 6.06 catechin equivalents mg/100 g extract.	Flavonoids	157-166	SM1	Homo sapiens	53-56
20691749-4	2010	SM1 and SM2 which contained high total phenolic and flavonoid had better antioxidant activities than the other varieties.	Flavonoids	52-61	SM1	Homo sapiens	0-3
19954946-3	2010	Luteolin, a naturally occurring flavonoid, has been demonstrated to inhibit lipopolysaccharide-induced tumor necrosis factor-alpha (TNFalpha) release and activation of NF-kappaB pathway in macrophages.	Flavonoids	32-41	tumor necrosis factor	Mus musculus	103-130
19954946-3	2010	Luteolin, a naturally occurring flavonoid, has been demonstrated to inhibit lipopolysaccharide-induced tumor necrosis factor-alpha (TNFalpha) release and activation of NF-kappaB pathway in macrophages.	Flavonoids	32-41	tumor necrosis factor	Mus musculus	132-140
20580034-3	2010	We hypothesize that flavonoids can down-regulate endothelial inflammatory parameters by modulating HO-1-regulated cell signaling.	Flavonoids	20-30	heme oxygenase 1	Homo sapiens	99-103
20580034-8	2010	These data suggest that the protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.	Flavonoids	53-63	heme oxygenase 1	Homo sapiens	157-196
20309792-0	2010	Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).	Flavonoids	35-45	GLI family zinc finger 2	Homo sapiens	104-109
20309792-0	2010	Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).	Flavonoids	35-45	lymphocyte antigen 96	Homo sapiens	179-212
20309792-0	2010	Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).	Flavonoids	35-45	lymphocyte antigen 96	Homo sapiens	214-218
20309792-3	2010	The anti-inflammatory activities of the flavonoids were measured by their ability to inhibit lipopolysaccharide (LPS)-induced cytokine production in human monocytic THP-1 cells.	Flavonoids	40-50	GLI family zinc finger 2	Homo sapiens	165-170
20309792-9	2010	Molecular docking studies showed that the complementarity of prenylated flavonoids with the hydrophobic MD-2 pocket (indicating goodness of fit) directly predicted their relative ability to inhibit MCP-1 and IL-6 production.	Flavonoids	72-82	C-C motif chemokine ligand 2	Homo sapiens	198-203
20309792-9	2010	Molecular docking studies showed that the complementarity of prenylated flavonoids with the hydrophobic MD-2 pocket (indicating goodness of fit) directly predicted their relative ability to inhibit MCP-1 and IL-6 production.	Flavonoids	72-82	interleukin 6	Homo sapiens	208-212
20309792-10	2010	In conclusion, prenylated flavonoids may suppress LPS-induced TLR4 activation at least partly by interfering with LPS binding to the TLR4 coreceptor MD-2, and XN (but not other prenylflavonoids) exerts an additional anti-inflammatory effect by downregulating the cellular TLR4 protein content.	Flavonoids	26-36	toll like receptor 4	Homo sapiens	62-66
20309792-10	2010	In conclusion, prenylated flavonoids may suppress LPS-induced TLR4 activation at least partly by interfering with LPS binding to the TLR4 coreceptor MD-2, and XN (but not other prenylflavonoids) exerts an additional anti-inflammatory effect by downregulating the cellular TLR4 protein content.	Flavonoids	26-36	toll like receptor 4	Homo sapiens	133-137
20309792-10	2010	In conclusion, prenylated flavonoids may suppress LPS-induced TLR4 activation at least partly by interfering with LPS binding to the TLR4 coreceptor MD-2, and XN (but not other prenylflavonoids) exerts an additional anti-inflammatory effect by downregulating the cellular TLR4 protein content.	Flavonoids	26-36	lymphocyte antigen 96	Homo sapiens	149-153
20309792-10	2010	In conclusion, prenylated flavonoids may suppress LPS-induced TLR4 activation at least partly by interfering with LPS binding to the TLR4 coreceptor MD-2, and XN (but not other prenylflavonoids) exerts an additional anti-inflammatory effect by downregulating the cellular TLR4 protein content.	Flavonoids	26-36	toll like receptor 4	Homo sapiens	133-137
20878708-6	2010	These results suggest that the flavonoids isolated from SPB, especially compounds 4 and 6, contribute to the inhibitory activity of S. polyrhiza in 3T3-L1 cells.	Flavonoids	31-41	surfactant associated protein B	Mus musculus	56-59
20735140-3	2010	6,6,8-Triethyldesmosdumotin B (2) was discovered as a MDR-selective flavonoid with significant in vitro anticancer activity against a multidrug resistant (MDR) cell line (KB-VIN) but without activity against the parent cells (KB).	Flavonoids	68-77	long intergenic non-protein coding RNA 1191	Homo sapiens	174-177
20452337-3	2010	Here, we searched potential AChE inhibitors from flavonoids, a group of naturally occurring compounds in plants or traditional Chinese medicines (TCM).	Flavonoids	49-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32
20578711-4	2010	In the present work, natural flavonoids were screened against cathepsin V, and two flavones were identified as potent inhibitors of cathepsin V.	Flavonoids	29-39	cathepsin V	Homo sapiens	62-73
20578711-4	2010	In the present work, natural flavonoids were screened against cathepsin V, and two flavones were identified as potent inhibitors of cathepsin V.	Flavonoids	29-39	cathepsin V	Homo sapiens	132-143
20452337-4	2010	Twenty-one flavonoids, covered different subclasses, were tested for their potential function in inhibiting AChE activity from the brain in vitro.	Flavonoids	11-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
20452337-6	2010	showed an inhibitory effect on AChE activity with the highest inhibition by over 55% and an IC(50) of 120 microM and an enzyme-flavonoid inhibition constant (K(i)) of 74 microM.	Flavonoids	127-136	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-35
20450880-0	2010	Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction.	Flavonoids	26-36	aryl-hydrocarbon receptor	Mus musculus	40-65
20824064-6	2010	CONCLUSIONS/SIGNIFICANCE: Several compounds from the flavonoid, indole and benzofuran chemical families emerged as binding partners and/or regulators of EAG1 channels.	Flavonoids	53-62	potassium voltage-gated channel subfamily H member 1	Homo sapiens	153-157
20450880-2	2010	Previously we demonstrated that flavonoids suppressed the TCDD-induced DNA-binding activity of the AhR in a structure-dependent manner.	Flavonoids	32-42	aryl-hydrocarbon receptor	Mus musculus	99-102
20450880-3	2010	In this study, we investigated the mechanisms by which flavonoids suppressed the AhR-mediated signal transduction in mouse hepatoma Hepa-1c1c7 cells.	Flavonoids	55-65	aryl-hydrocarbon receptor	Mus musculus	81-84
20450880-5	2010	Flavonoids of all these four subclasses suppressed the phosphorylation of both AhR and Arnt and the formation of a heterodimer consisting of these proteins.	Flavonoids	0-10	aryl-hydrocarbon receptor	Mus musculus	79-82
20450880-5	2010	Flavonoids of all these four subclasses suppressed the phosphorylation of both AhR and Arnt and the formation of a heterodimer consisting of these proteins.	Flavonoids	0-10	aryl hydrocarbon receptor nuclear translocator	Mus musculus	87-91
20450880-6	2010	Since certain flavonoids are known to inhibit mitogen-activated protein kinases (MAPKs), we confirmed the contribution of MAPK/ERK kinase (MEK) to the AhR-mediated signal transduction by using U0126, an inhibitor of MEK1/2.	Flavonoids	14-24	mitogen-activated protein kinase 1	Mus musculus	81-85
20450880-6	2010	Since certain flavonoids are known to inhibit mitogen-activated protein kinases (MAPKs), we confirmed the contribution of MAPK/ERK kinase (MEK) to the AhR-mediated signal transduction by using U0126, an inhibitor of MEK1/2.	Flavonoids	14-24	mitogen-activated protein kinase 1	Mus musculus	127-130
20450880-6	2010	Since certain flavonoids are known to inhibit mitogen-activated protein kinases (MAPKs), we confirmed the contribution of MAPK/ERK kinase (MEK) to the AhR-mediated signal transduction by using U0126, an inhibitor of MEK1/2.	Flavonoids	14-24	aryl-hydrocarbon receptor	Mus musculus	151-154
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Flavonoids	23-33	mitogen activated protein kinase 3	Rattus norvegicus	118-124
20696580-3	2010	In this study, we first evaluated the structure-property relationship of 18 major flavonoids on inhibiting enzymatic activity of CYP1A1, 1A2 and 1B1 by using an ethoxyresorufin O-deethylation assay.	Flavonoids	82-92	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	129-135
20696580-5	2010	Flavonoids used in this study selectively inhibited CYP1B1 activity.	Flavonoids	0-10	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	52-58
20696580-9	2010	In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues.	Flavonoids	73-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-91
20696580-9	2010	In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues.	Flavonoids	73-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	237-243
20696580-9	2010	In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues.	Flavonoids	73-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	237-241
20696580-9	2010	In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues.	Flavonoids	157-167	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-91
20696580-9	2010	In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues.	Flavonoids	157-167	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	237-243
20696580-9	2010	In conclusion, our results demonstrate: (1) strong inhibitory effects of flavonoids on CYP1 activities require the 2-3 double bond on the C-ring; (2) methoxyflavonoids with the 2-3 double bond had strong and selective inhibition against CYP1B1, suggesting chemopreventive flavonoids for E(2) related breast cancer; and (3) binding specificity of these methoxyflavonoids is based on the interactions between the methoxy groups and specific CYP1s residues.	Flavonoids	157-167	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	237-241
20823598-0	2010	A quantitative structure-activity relationship for the modulation effects of flavonoids on p-glycoprotein-mediated transport.	Flavonoids	77-87	ATP binding cassette subfamily B member 1	Homo sapiens	91-105
20823598-2	2010	The aim of this study was to establish the qualitative and quantitative structure-activity relationships (QSAR) of flavonoid modulation effects on P-glycoprotein (P-gp)"s function.	Flavonoids	115-124	ATP binding cassette subfamily B member 1	Homo sapiens	147-161
20823598-2	2010	The aim of this study was to establish the qualitative and quantitative structure-activity relationships (QSAR) of flavonoid modulation effects on P-glycoprotein (P-gp)"s function.	Flavonoids	115-124	ATP binding cassette subfamily B member 1	Homo sapiens	163-167
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Flavonoids	23-33	mitogen-activated protein kinase 8	Rattus norvegicus	126-129
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Flavonoids	23-33	mitogen activated protein kinase 14	Rattus norvegicus	131-134
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Flavonoids	23-33	AKT serine/threonine kinase 1	Rattus norvegicus	140-143
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Flavonoids	23-33	interleukin 1 beta	Rattus norvegicus	164-173
20660284-1	2010	The citrus flavonoids hesperidin and naringin have been suggested to lower blood total (TC) and LDL-cholesterol (LDL-C) both in animal models and humans.	Flavonoids	11-21	component of oligomeric golgi complex 2	Homo sapiens	96-111
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	Flavonoids	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	Flavonoids	22-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
20660284-1	2010	The citrus flavonoids hesperidin and naringin have been suggested to lower blood total (TC) and LDL-cholesterol (LDL-C) both in animal models and humans.	Flavonoids	11-21	component of oligomeric golgi complex 2	Homo sapiens	113-118
20649574-6	2010	KEY RESULTS: The effect of flavonoids on COX-2 expression depended on the experimental conditions tested [non-stimulated and lipopolysaccharide (LPS)-stimulated].	Flavonoids	27-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46
20580386-4	2010	In this study, an O-methyltransferase cDNA that showed a distinct expression pattern when compared to closely related sequences was expressed in Escherichia coli and enzyme assays were carried out with a broad array of anthocyanin and other flavonoid substrates.	Flavonoids	241-250	O-methyltransferase	Vitis vinifera	18-37
20457140-3	2010	In the present study it is shown that the flavonoid chrysin acts as a potent inhibitor of P-gp, MRP-2, and BCRP in Caco-2 colon carcinoma cells.	Flavonoids	42-51	ATP binding cassette subfamily C member 2	Homo sapiens	96-101
20457140-3	2010	In the present study it is shown that the flavonoid chrysin acts as a potent inhibitor of P-gp, MRP-2, and BCRP in Caco-2 colon carcinoma cells.	Flavonoids	42-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	107-111
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	peroxisome proliferator activated receptor alpha	Homo sapiens	24-28
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	nuclear receptor subfamily 1 group H member 3	Homo sapiens	71-79
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	peroxisome proliferator activated receptor alpha	Homo sapiens	160-164
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	acyl-CoA oxidase 1	Homo sapiens	219-223
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	uncoupling protein 1	Homo sapiens	225-229
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	nuclear receptor subfamily 1 group H member 3	Homo sapiens	259-267
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	ATP binding cassette subfamily A member 1	Homo sapiens	310-315
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	ATP binding cassette subfamily G member 1	Homo sapiens	317-322
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	high mobility group AT-hook 1	Homo sapiens	328-332
20564233-0	2010	Inhibition of beta-catenin/Tcf signaling by flavonoids.	Flavonoids	44-54	catenin beta 1	Homo sapiens	14-26
20564233-0	2010	Inhibition of beta-catenin/Tcf signaling by flavonoids.	Flavonoids	44-54	hepatocyte nuclear factor 4 alpha	Homo sapiens	27-30
20564233-2	2010	We identified the inhibitory effect of various polyphenolic flavonoid compounds against beta-catenin/Tcf signaling in beta-catenin-activated cells.	Flavonoids	60-69	catenin beta 1	Homo sapiens	88-100
20564233-2	2010	We identified the inhibitory effect of various polyphenolic flavonoid compounds against beta-catenin/Tcf signaling in beta-catenin-activated cells.	Flavonoids	60-69	hepatocyte nuclear factor 4 alpha	Homo sapiens	101-104
20564233-2	2010	We identified the inhibitory effect of various polyphenolic flavonoid compounds against beta-catenin/Tcf signaling in beta-catenin-activated cells.	Flavonoids	60-69	catenin beta 1	Homo sapiens	118-130
20564233-5	2010	The shift assay showed that the binding of Tcf complexes with its specific DNA-binding sites was suppressed by four kinds of flavonoids.	Flavonoids	125-135	hepatocyte nuclear factor 4 alpha	Homo sapiens	43-46
20564233-6	2010	Immunoprecipitation analysis also showed that the binding of beta-catenin to Tcf-4 was also disrupted by these flavonoids.	Flavonoids	111-121	catenin beta 1	Homo sapiens	61-73
20564233-6	2010	Immunoprecipitation analysis also showed that the binding of beta-catenin to Tcf-4 was also disrupted by these flavonoids.	Flavonoids	111-121	transcription factor 4	Homo sapiens	77-82
20564233-9	2010	Taken together, these results suggest that the polyphenolic flavonoids genistein, kaempferol, isorhamnentin, and baicalein are negative regulators of beta-catenin/Tcf signaling and their inhibitory mechanism is related to the decreased binding of beta-catenin/Tcf complexes to consensus DNA.	Flavonoids	60-70	catenin beta 1	Homo sapiens	150-162
20564233-9	2010	Taken together, these results suggest that the polyphenolic flavonoids genistein, kaempferol, isorhamnentin, and baicalein are negative regulators of beta-catenin/Tcf signaling and their inhibitory mechanism is related to the decreased binding of beta-catenin/Tcf complexes to consensus DNA.	Flavonoids	60-70	hepatocyte nuclear factor 4 alpha	Homo sapiens	163-166
20564233-9	2010	Taken together, these results suggest that the polyphenolic flavonoids genistein, kaempferol, isorhamnentin, and baicalein are negative regulators of beta-catenin/Tcf signaling and their inhibitory mechanism is related to the decreased binding of beta-catenin/Tcf complexes to consensus DNA.	Flavonoids	60-70	catenin beta 1	Homo sapiens	247-259
20564233-9	2010	Taken together, these results suggest that the polyphenolic flavonoids genistein, kaempferol, isorhamnentin, and baicalein are negative regulators of beta-catenin/Tcf signaling and their inhibitory mechanism is related to the decreased binding of beta-catenin/Tcf complexes to consensus DNA.	Flavonoids	60-70	hepatocyte nuclear factor 4 alpha	Homo sapiens	260-263
20627088-2	2010	We report that baicalin, a natural flavonoid compound, inhibits adipogenesis by modulating beta-Catenin.	Flavonoids	35-44	catenin (cadherin associated protein), beta 1	Mus musculus	91-103
20649574-0	2010	Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF-kappaB in an intestinal epithelial cell line (IEC18).	Flavonoids	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-64
20649574-0	2010	Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF-kappaB in an intestinal epithelial cell line (IEC18).	Flavonoids	0-10	nuclear factor kappa B subunit 1	Homo sapiens	69-78
20649574-2	2010	We aimed to characterize the effect and structure-activity relationship of nine selected flavonoids on COX-2 expression in intestinal epithelial cell (IEC)18 cells.	Flavonoids	89-99	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
20649574-7	2010	Flavonoids caused an increase in COX-2 expression and NF-kappaB-dependent gene transcription under basal conditions.	Flavonoids	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-38
20649574-7	2010	Flavonoids caused an increase in COX-2 expression and NF-kappaB-dependent gene transcription under basal conditions.	Flavonoids	0-10	nuclear factor kappa B subunit 1	Homo sapiens	54-63
20649574-10	2010	CONCLUSION AND IMPLICATIONS: The effect of flavonoids on COX-2 expression depended on the balance of the interference with IkappaB-alpha phosphorylation and other signalling targets, and therefore depends on the experimental conditions and on the type of flavonoids.	Flavonoids	43-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-62
20649574-10	2010	CONCLUSION AND IMPLICATIONS: The effect of flavonoids on COX-2 expression depended on the balance of the interference with IkappaB-alpha phosphorylation and other signalling targets, and therefore depends on the experimental conditions and on the type of flavonoids.	Flavonoids	43-53	NFKB inhibitor alpha	Homo sapiens	123-136
20649574-10	2010	CONCLUSION AND IMPLICATIONS: The effect of flavonoids on COX-2 expression depended on the balance of the interference with IkappaB-alpha phosphorylation and other signalling targets, and therefore depends on the experimental conditions and on the type of flavonoids.	Flavonoids	255-265	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-62
20649574-12	2010	In general, flavonoids may limit epithelial COX-2 expression in inflammatory conditions while favouring it when inflammation is not present.	Flavonoids	12-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-49
20411407-4	2010	RESULTS: GSMF experiments indicated that both flavonoids were metabolized mainly by UGT1As, with major contributions from UGT1A3 and UGT1A7-1A10.	Flavonoids	46-56	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	122-128
20530556-3	2010	Here, we show that the treatment of androgen-independent and PTEN-negative human CaP PC3 cells with fisetin, a dietary flavonoid, resulted in inhibition of mTOR kinase signaling pathway.	Flavonoids	119-128	phosphatase and tensin homolog	Homo sapiens	61-65
20530556-3	2010	Here, we show that the treatment of androgen-independent and PTEN-negative human CaP PC3 cells with fisetin, a dietary flavonoid, resulted in inhibition of mTOR kinase signaling pathway.	Flavonoids	119-128	mechanistic target of rapamycin kinase	Homo sapiens	156-160
20569521-4	2010	The anti-inflammatory actions of flavonoids in vitro or in cellular models involve the inhibition of the synthesis and activities of different pro-inflammatory mediators such as eicosanoids, cytokines, adhesion molecules and C-reactive protein.	Flavonoids	33-43	C-reactive protein	Homo sapiens	225-243
20798327-3	2010	The phenotypes of diminished oil in seeds, reduced flavonoids and aromatic amino acids in flowers, compromised lignin biosynthesis in stems, and aberrant exine formation in pollen indicate that cue1/eno1(+/-) disrupts multiple pathways.	Flavonoids	51-61	Glucose-6-phosphate/phosphate translocator-like protein	Arabidopsis thaliana	194-198
20798327-3	2010	The phenotypes of diminished oil in seeds, reduced flavonoids and aromatic amino acids in flowers, compromised lignin biosynthesis in stems, and aberrant exine formation in pollen indicate that cue1/eno1(+/-) disrupts multiple pathways.	Flavonoids	51-61	enolase 1	Arabidopsis thaliana	199-203
20569521-5	2010	Molecular activities of flavonoids include inhibition of transcription factors such as NF-kappaB and activating protein-1 (AP-1), as well as activation of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Flavonoids	24-34	NFE2 like bZIP transcription factor 2	Homo sapiens	155-198
20569521-5	2010	Molecular activities of flavonoids include inhibition of transcription factors such as NF-kappaB and activating protein-1 (AP-1), as well as activation of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Flavonoids	24-34	NFE2 like bZIP transcription factor 2	Homo sapiens	200-204
20579654-2	2010	The perphenylcarbamated CD CSP (CCP-CSP) exhibited excellent chiral recognition of a wide range of analytes including racemic aryl alcohols, flavonoids, bendroflumethiazide, atropine and some beta-blockers.	Flavonoids	141-151	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	27-30
20579654-2	2010	The perphenylcarbamated CD CSP (CCP-CSP) exhibited excellent chiral recognition of a wide range of analytes including racemic aryl alcohols, flavonoids, bendroflumethiazide, atropine and some beta-blockers.	Flavonoids	141-151	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	36-39
20583750-0	2010	Cytotoxic flavonoids as agonists of peroxisome proliferator-activated receptor gamma on human cervical and prostate cancer cells.	Flavonoids	10-20	peroxisome proliferator activated receptor gamma	Homo sapiens	36-84
20599706-0	2010	Flavonoid binding to human serum albumin.	Flavonoids	0-9	albumin	Homo sapiens	27-40
20550209-1	2010	Galangin, a dietary flavonoid, inhibited cytochrome P450 1A1 (CYP1A1) expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Flavonoids	20-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-60
20566705-6	2010	Thus, PAL1 and PAL2 have a redundant role in flavonoid biosynthesis.	Flavonoids	45-54	PHE ammonia lyase 1	Arabidopsis thaliana	6-10
20566705-6	2010	Thus, PAL1 and PAL2 have a redundant role in flavonoid biosynthesis.	Flavonoids	45-54	phenylalanine ammonia-lyase 2	Arabidopsis thaliana	15-19
20558139-5	2010	In this report we investigate the effect of the dietary flavonoid kaempferol on activity, expression levels and localization of HIF-1alpha as well as viability of human hepatoma (Huh7) cancer cells.	Flavonoids	56-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
20550209-1	2010	Galangin, a dietary flavonoid, inhibited cytochrome P450 1A1 (CYP1A1) expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Flavonoids	20-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	62-68
20583750-1	2010	We conducted in silico screening for human peroxisome proliferator-activated receptor gamma (hPPARgamma) by performing an automated docking study with 450 flavonoids.	Flavonoids	155-165	peroxisome proliferator activated receptor gamma	Homo sapiens	43-91
20583750-1	2010	We conducted in silico screening for human peroxisome proliferator-activated receptor gamma (hPPARgamma) by performing an automated docking study with 450 flavonoids.	Flavonoids	155-165	peroxisome proliferator activated receptor gamma	Homo sapiens	93-103
20583750-2	2010	Among the eight flavonoids as possible agonists of hPPARgamma, only 3,6-dihydroxyflavone (4) increased the binding between PPARgamma and steroid receptor coactivator-1 (SRC-1), approximately 5-fold, and showed one order higher binding affinity for PPARgamma than a reference compound, indomethacin.	Flavonoids	16-26	peroxisome proliferator activated receptor gamma	Homo sapiens	51-61
20583750-2	2010	Among the eight flavonoids as possible agonists of hPPARgamma, only 3,6-dihydroxyflavone (4) increased the binding between PPARgamma and steroid receptor coactivator-1 (SRC-1), approximately 5-fold, and showed one order higher binding affinity for PPARgamma than a reference compound, indomethacin.	Flavonoids	16-26	peroxisome proliferator activated receptor gamma	Homo sapiens	52-61
20369276-0	2010	Effects of single and multiple flavonoids on BCRP-mediated accumulation, cytotoxicity and transport of mitoxantrone in vitro.	Flavonoids	31-41	BCR pseudogene 1	Homo sapiens	45-49
20806393-1	2010	The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined.	Flavonoids	26-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-69
20806393-1	2010	The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined.	Flavonoids	26-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
20806393-3	2010	Although apigenin belonging to flavones and genistein belonging to isoflavones are similar in the chemical structures, the inhibitory potencies for CYP1A2 were distinguished markedly between these two flavonoids.	Flavonoids	201-211	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	148-154
19576747-3	2010	We previously reported that the dietary flavonoid phloretin enhances 3T3-L1 adipocyte differentiation and adiponectin expression at least in part through PPAR gamma activation.	Flavonoids	40-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	106-117
19576747-3	2010	We previously reported that the dietary flavonoid phloretin enhances 3T3-L1 adipocyte differentiation and adiponectin expression at least in part through PPAR gamma activation.	Flavonoids	40-49	peroxisome proliferator activated receptor gamma	Homo sapiens	154-164
20369276-1	2010	PURPOSE: The objective of our study was to investigate the effect of single and multiple flavonoids on the accumulation and cytotoxicity of mitoxantrone in BCRP-overexpressing breast cancer cells and on the transport of mitoxantrone in BCRP-expressing normal cells.	Flavonoids	89-99	BCR pseudogene 1	Homo sapiens	156-160
20369276-4	2010	RESULTS: Our results demonstrated that multiple flavonoid combinations act additively and exhibit strong BCRP inhibition for increasing mitoxantrone accumulation in breast cancer cells.	Flavonoids	48-57	BCR pseudogene 1	Homo sapiens	105-109
20369276-7	2010	CONCLUSION: The results indicate that flavonoids are potent BCRP inhibitors and that they exert additive effects when used in combination.	Flavonoids	38-48	BCR pseudogene 1	Homo sapiens	60-64
20553580-0	2010	Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells.	Flavonoids	0-10	nuclear receptor subfamily 1 group I member 2	Homo sapiens	20-39
20442277-5	2010	LAP5 and LAP6 encode anther-specific proteins with homology to chalcone synthase, a key flavonoid biosynthesis enzyme.	Flavonoids	88-97	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-4
20442277-5	2010	LAP5 and LAP6 encode anther-specific proteins with homology to chalcone synthase, a key flavonoid biosynthesis enzyme.	Flavonoids	88-97	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	9-13
20442277-6	2010	lap5 and lap6 mutations reduced the accumulation of flavonoid precursors and flavonoids in developing anthers, suggesting a role in the synthesis of phenolic constituents of sporopollenin.	Flavonoids	52-61	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-4
20442277-6	2010	lap5 and lap6 mutations reduced the accumulation of flavonoid precursors and flavonoids in developing anthers, suggesting a role in the synthesis of phenolic constituents of sporopollenin.	Flavonoids	52-61	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	9-13
20442277-6	2010	lap5 and lap6 mutations reduced the accumulation of flavonoid precursors and flavonoids in developing anthers, suggesting a role in the synthesis of phenolic constituents of sporopollenin.	Flavonoids	77-87	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	0-4
20442277-6	2010	lap5 and lap6 mutations reduced the accumulation of flavonoid precursors and flavonoids in developing anthers, suggesting a role in the synthesis of phenolic constituents of sporopollenin.	Flavonoids	77-87	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	9-13
20402563-0	2010	In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity.	Flavonoids	43-53	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	57-76
20402563-0	2010	In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity.	Flavonoids	43-53	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	78-84
20402563-2	2010	The effect of flavonoids on coumarin 7-hydroxylation, an activity marker of an important human liver cytochrome P450 isoform, cytochrome P450 2A6 (CYP2A6), was investigated in this study.	Flavonoids	14-24	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	126-145
20402563-4	2010	Coumarin 7-hydroxylase activity was measured fluorometrically in reaction mixtures containing cDNA-expressed CYP2A6, nicotinamide adenine dinucleotide phosphate generating system and 10 uM coumarin, at various concentrations of flavonoids.	Flavonoids	228-238	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-22
20553580-0	2010	Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells.	Flavonoids	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55
20553580-2	2010	Flavonoids, commonly consumed by humans as dietary constituents, have been shown to modulate various signaling pathways (e.g., inhibiting Cdks).	Flavonoids	0-10	cyclin dependent kinase 5	Homo sapiens	138-142
20553580-4	2010	Here, we report the mechanism responsible for flavonoid-mediated PXR activation and CYP expression.	Flavonoids	46-55	nuclear receptor subfamily 1 group I member 2	Homo sapiens	65-68
20553580-5	2010	RESULTS: In a cell-based screen designed to identify compounds that activate PXR-mediated CYP3A4 gene expression in HepG2 human carcinoma cells, we identified several flavonoids, such as luteolin and apigenin, as PXR activators.	Flavonoids	167-177	nuclear receptor subfamily 1 group I member 2	Homo sapiens	77-80
20553580-5	2010	RESULTS: In a cell-based screen designed to identify compounds that activate PXR-mediated CYP3A4 gene expression in HepG2 human carcinoma cells, we identified several flavonoids, such as luteolin and apigenin, as PXR activators.	Flavonoids	167-177	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
21346872-3	2010	In the present insilico study, the inhibitory effect of different flavonoid compounds on mutant H Ras protein p21 has been assessed.	Flavonoids	66-75	H3 histone pseudogene 16	Homo sapiens	110-113
20553580-5	2010	RESULTS: In a cell-based screen designed to identify compounds that activate PXR-mediated CYP3A4 gene expression in HepG2 human carcinoma cells, we identified several flavonoids, such as luteolin and apigenin, as PXR activators.	Flavonoids	167-177	nuclear receptor subfamily 1 group I member 2	Homo sapiens	213-216
21346872-7	2010	Our study demonstrates that flavonoids (particularly Naringenin, Daidzein, and Hesperetin) are the effective drugs to inhibit function of mutant H-Ras P21 protein, which in turn arrests the process of cell growth and proliferation of the cancer cell.	Flavonoids	28-38	HRas proto-oncogene, GTPase	Homo sapiens	145-150
20553580-6	2010	The flavonoids did not directly bind to PXR, suggesting that an alternative mechanism may be responsible for flavonoid-mediated PXR activation.	Flavonoids	4-14	nuclear receptor subfamily 1 group I member 2	Homo sapiens	128-131
21346872-7	2010	Our study demonstrates that flavonoids (particularly Naringenin, Daidzein, and Hesperetin) are the effective drugs to inhibit function of mutant H-Ras P21 protein, which in turn arrests the process of cell growth and proliferation of the cancer cell.	Flavonoids	28-38	H3 histone pseudogene 16	Homo sapiens	151-154
20553580-6	2010	The flavonoids did not directly bind to PXR, suggesting that an alternative mechanism may be responsible for flavonoid-mediated PXR activation.	Flavonoids	4-13	nuclear receptor subfamily 1 group I member 2	Homo sapiens	128-131
20553580-7	2010	Consistent with the Cdk5-inhibitory effect of flavonoids, Cdk5 and p35 (a non-cyclin regulatory subunit required to activate Cdk5) were expressed in HepG2.	Flavonoids	46-56	cyclin dependent kinase 5	Homo sapiens	20-24
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	77-87	cyclin dependent kinase 5	Homo sapiens	4-8
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	77-87	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	36-42
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	77-87	nuclear receptor subfamily 1 group I member 2	Homo sapiens	125-128
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	77-87	cyclin dependent kinase 5	Homo sapiens	145-149
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	105-115	cyclin dependent kinase 5	Homo sapiens	4-8
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	105-115	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	36-42
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	105-115	nuclear receptor subfamily 1 group I member 2	Homo sapiens	125-128
20553580-9	2010	The Cdk5-mediated downregulation of CYP3A4 promoter activity was restored by flavonoids, suggesting that flavonoids activate PXR by inactivating Cdk5.	Flavonoids	105-115	cyclin dependent kinase 5	Homo sapiens	145-149
20553580-11	2010	The Cdk kinase profiling assay showed that apigenin inhibits multiple Cdks, suggesting that several Cdks may be involved in activation of PXR by flavonoids.	Flavonoids	145-155	cyclin dependent kinase 5	Homo sapiens	100-104
20553580-11	2010	The Cdk kinase profiling assay showed that apigenin inhibits multiple Cdks, suggesting that several Cdks may be involved in activation of PXR by flavonoids.	Flavonoids	145-155	nuclear receptor subfamily 1 group I member 2	Homo sapiens	138-141
20553580-12	2010	CONCLUSIONS: Our results for the first time link the stimulatory effect of flavonoids on CYP expression to their inhibitory effect on Cdks, through a PXR-mediated mechanism.	Flavonoids	75-85	cyclin dependent kinase 5	Homo sapiens	134-138
20553580-12	2010	CONCLUSIONS: Our results for the first time link the stimulatory effect of flavonoids on CYP expression to their inhibitory effect on Cdks, through a PXR-mediated mechanism.	Flavonoids	75-85	nuclear receptor subfamily 1 group I member 2	Homo sapiens	150-153
20524817-7	2010	Similarly, the flavonoid quercetin abolished the influence of iron on the activity of TrxR.	Flavonoids	15-24	peroxiredoxin 5	Rattus norvegicus	86-90
20540768-4	2010	We have previously demonstrated that the bioflavonoid quercetin (Qct) promoted a p53-mediated response and sensitized melanoma to DTIC.	Flavonoids	41-53	tumor protein p53	Homo sapiens	81-84
20153296-0	2010	Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.	Flavonoids	0-10	vascular endothelial growth factor A	Homo sapiens	35-69
20153296-0	2010	Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.	Flavonoids	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-91
20153296-2	2010	In this work we analyzed the effect of a group of 20 structurally related flavonoids, including flavones, flavonols and isoflavones, on the production of vascular endothelial growth factor (VEGF) induced by hypoxia in NCI-H157 cells.	Flavonoids	74-84	vascular endothelial growth factor A	Homo sapiens	154-188
20153296-2	2010	In this work we analyzed the effect of a group of 20 structurally related flavonoids, including flavones, flavonols and isoflavones, on the production of vascular endothelial growth factor (VEGF) induced by hypoxia in NCI-H157 cells.	Flavonoids	74-84	vascular endothelial growth factor A	Homo sapiens	190-194
20153296-7	2010	When cells were exposed to hypoxia in the presence of these flavonoids, HIF-1alpha translocated to the nucleus and interacted with p300/CBP, but this complex was transcriptionally inactive.	Flavonoids	60-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-82
20153296-7	2010	When cells were exposed to hypoxia in the presence of these flavonoids, HIF-1alpha translocated to the nucleus and interacted with p300/CBP, but this complex was transcriptionally inactive.	Flavonoids	60-70	E1A binding protein p300	Homo sapiens	131-135
20153296-7	2010	When cells were exposed to hypoxia in the presence of these flavonoids, HIF-1alpha translocated to the nucleus and interacted with p300/CBP, but this complex was transcriptionally inactive.	Flavonoids	60-70	CREB binding protein	Homo sapiens	136-139
20153296-8	2010	Taken together these findings indicate that flavonoids impair VEGF transcription by an alternative mechanism that did not depend on nuclear HIF levels.	Flavonoids	44-54	vascular endothelial growth factor A	Homo sapiens	62-66
20153296-9	2010	We also found that flavonoids suppressed hypoxia-induced STAT3 tyrosine phosphorylation and that this activity correlated with their potency as VEGF inhibitors, suggesting that inhibition of STAT3 function may play a role in this process.	Flavonoids	19-29	signal transducer and activator of transcription 3	Homo sapiens	57-62
20153296-9	2010	We also found that flavonoids suppressed hypoxia-induced STAT3 tyrosine phosphorylation and that this activity correlated with their potency as VEGF inhibitors, suggesting that inhibition of STAT3 function may play a role in this process.	Flavonoids	19-29	vascular endothelial growth factor A	Homo sapiens	144-148
20153296-9	2010	We also found that flavonoids suppressed hypoxia-induced STAT3 tyrosine phosphorylation and that this activity correlated with their potency as VEGF inhibitors, suggesting that inhibition of STAT3 function may play a role in this process.	Flavonoids	19-29	signal transducer and activator of transcription 3	Homo sapiens	191-196
19902529-1	2010	The interaction between quercetin, a popular antioxidant flavonoid, and human serum albumin (HSA) is investigated and characterized by means of induced circular dichroism and saturation transfer difference NMR.	Flavonoids	57-66	albumin	Homo sapiens	78-91
20112299-3	2010	Flavonoids may interfere with hesperetin metabolism and can also inhibit the apically located ABC transporter breast cancer resistance protein (ABCG2) which was previously shown to be responsible for the apical transport of hesperetin metabolites.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	110-142
20112299-3	2010	Flavonoids may interfere with hesperetin metabolism and can also inhibit the apically located ABC transporter breast cancer resistance protein (ABCG2) which was previously shown to be responsible for the apical transport of hesperetin metabolites.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-149
20369844-5	2010	In this work, we employ atomistic, explicit-solvent molecular dynamics (MD) simulations to identify the mechanism of Abeta fibril destabilization by morin, one of the most effective anti-aggregation flavonoids, using a model of the mature Abeta fibril.	Flavonoids	199-209	amyloid beta precursor protein	Homo sapiens	117-122
19911203-0	2010	Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: a steered molecular dynamics study.	Flavonoids	36-45	arachidonate 15-lipoxygenase	Homo sapiens	66-90
20026081-1	2010	Isoliquiritigenin (ILQ), a flavonoid compound originated from Glycyrrhiza species, is known to activate SIRT1.	Flavonoids	27-36	sirtuin 1	Homo sapiens	104-109
19911203-2	2010	In this work, we docked arachidonic acid and two of its competitive inhibitors, flavonoids baicalein and quercetin, into the binding pockets of human 12- and 15-lipoxygenase.	Flavonoids	80-90	arachidonate 15-lipoxygenase	Homo sapiens	150-173
20118183-0	2010	The basic helix-loop-helix transcription factor MYC1 is involved in the regulation of the flavonoid biosynthesis pathway in grapevine.	Flavonoids	90-99	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	48-52
20175127-5	2010	This flavonoid induced the phosphorylation of members of the mitogen-activated protein kinases (MAPKs) family and cell death was attenuated by inhibition of c-jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and of extracellular signal-regulated kinases (ERK) 1/2.	Flavonoids	5-14	mitogen-activated protein kinase 8	Homo sapiens	216-224
20175127-5	2010	This flavonoid induced the phosphorylation of members of the mitogen-activated protein kinases (MAPKs) family and cell death was attenuated by inhibition of c-jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and of extracellular signal-regulated kinases (ERK) 1/2.	Flavonoids	5-14	mitogen-activated protein kinase 1	Homo sapiens	233-281
20118183-4	2010	Transient promoter and yeast two-hybrid assays demonstrated that VvMYC1 physically interacts with MYB5a, MYB5b, MYBA1/A2, and MYBPA1 to induce promoters of flavonoid pathway genes involved in anthocyanin and/or proanthocyanidin (PA) synthesis.	Flavonoids	156-165	Basic helix-loop-helix protein A	Vitis vinifera	65-71
20118183-4	2010	Transient promoter and yeast two-hybrid assays demonstrated that VvMYC1 physically interacts with MYB5a, MYB5b, MYBA1/A2, and MYBPA1 to induce promoters of flavonoid pathway genes involved in anthocyanin and/or proanthocyanidin (PA) synthesis.	Flavonoids	156-165	MYBA1	Vitis vinifera	112-117
20102149-3	2010	Recent in vitro studies demonstrate that anthocyanins and other flavonoids interact directly with rhodopsin and modulate visual pigment function.	Flavonoids	64-74	rhodopsin	Homo sapiens	98-107
20873564-0	2010	[Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase].	Flavonoids	26-36	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	58-86
20873564-9	2010	The inhibitory effect of flavonoids on PRL-3 was increased with the number of hydroxyl group.	Flavonoids	25-35	protein tyrosine phosphatase 4A3	Homo sapiens	39-44
20152892-17	2010	CONCLUSIONS: We suggest that the flavonoids isolated from F I and II (vitexin, isovitexin, rhamnopyranosylvitexin and isoembigenin) contribute to the anti-MPO activity, as well as to their anti-Helicobacter pylori activity.	Flavonoids	33-43	myeloperoxidase	Rattus norvegicus	155-158
20230793-0	2010	The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.	Flavonoids	11-21	tumor necrosis factor	Mus musculus	79-88
20230793-3	2010	In this report, we show that hesperetin and naringenin, two citrus flavonoids, inhibit TNF-alpha-stimulated FFA secretion from mouse adipocytes.	Flavonoids	67-77	tumor necrosis factor	Mus musculus	87-96
20230793-4	2010	These flavonoids block the TNF-alpha-induced activation of the NF-kappaB and ERK pathways.	Flavonoids	6-16	tumor necrosis factor	Mus musculus	27-36
20230793-4	2010	These flavonoids block the TNF-alpha-induced activation of the NF-kappaB and ERK pathways.	Flavonoids	6-16	mitogen-activated protein kinase 1	Mus musculus	77-80
20205645-5	2010	In addition, we examine potential therapeutic strategies such as statins, flavonoids, and human umbilical cord blood transplantation, all of which have been shown to modulate CD40-CD40L interaction in mouse models of AD.	Flavonoids	74-84	CD40 molecule	Homo sapiens	175-179
20110573-13	2010	CONCLUSIONS: These in vivo studies demonstrate that the citrus flavonoid naringenin ameliorates the dyslipidemia in Western-fed low-density lipoprotein receptor-null mice, leading to decreased atherosclerosis; and suggests a potential therapeutic strategy for the hyperlipidemia and increased risk of atherosclerosis associated with insulin resistance.	Flavonoids	63-72	low density lipoprotein receptor	Mus musculus	128-160
20423617-2	2010	Our results showed that over-expression of collagen mRNA and protein induced in cardiac fibroblasts by angiotensin (AngII) could be attenuated significantly by both flavonoids at an optimal dosage (30 microM; P &lt; 0.01).	Flavonoids	165-175	angiotensinogen	Rattus norvegicus	103-114
20423617-2	2010	Our results showed that over-expression of collagen mRNA and protein induced in cardiac fibroblasts by angiotensin (AngII) could be attenuated significantly by both flavonoids at an optimal dosage (30 microM; P &lt; 0.01).	Flavonoids	165-175	angiotensinogen	Rattus norvegicus	116-121
20423617-3	2010	Results of immunoblots showed that expression of 12-LO level, p-ERK/ ERK ratio and MMP-9 in AngII -stimulated SHR cardiac fibroblasts were significantly down-regulated by both flavonoids.	Flavonoids	176-186	Eph receptor B1	Rattus norvegicus	64-67
20423617-3	2010	Results of immunoblots showed that expression of 12-LO level, p-ERK/ ERK ratio and MMP-9 in AngII -stimulated SHR cardiac fibroblasts were significantly down-regulated by both flavonoids.	Flavonoids	176-186	Eph receptor B1	Rattus norvegicus	69-72
20423617-3	2010	Results of immunoblots showed that expression of 12-LO level, p-ERK/ ERK ratio and MMP-9 in AngII -stimulated SHR cardiac fibroblasts were significantly down-regulated by both flavonoids.	Flavonoids	176-186	matrix metallopeptidase 9	Rattus norvegicus	83-88
20423617-3	2010	Results of immunoblots showed that expression of 12-LO level, p-ERK/ ERK ratio and MMP-9 in AngII -stimulated SHR cardiac fibroblasts were significantly down-regulated by both flavonoids.	Flavonoids	176-186	angiotensinogen	Rattus norvegicus	92-97
20205645-5	2010	In addition, we examine potential therapeutic strategies such as statins, flavonoids, and human umbilical cord blood transplantation, all of which have been shown to modulate CD40-CD40L interaction in mouse models of AD.	Flavonoids	74-84	CD40 ligand	Homo sapiens	180-185
20153368-4	2010	However, mounting evidence indicate that flavonoids are also capable of acting as CYP1 substrates, undergoing bioactivation to more antiproliferative agents within cancer cells.	Flavonoids	41-51	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-86
20153368-0	2010	Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes.	Flavonoids	8-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-102
20487633-0	2010	Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy.	Flavonoids	62-72	ATP binding cassette subfamily B member 1	Homo sapiens	35-49
20170340-0	2010	The natural flavonoid apigenin suppresses Th1- and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase pathways.	Flavonoids	12-21	negative elongation factor complex member C/D	Homo sapiens	42-45
20170340-0	2010	The natural flavonoid apigenin suppresses Th1- and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase pathways.	Flavonoids	12-21	GLI family zinc finger 2	Homo sapiens	102-107
20153368-3	2010	Flavonoids have traditionally been described as CYP1 inhibitors due to the inhibition of carcinogenic product formation and consequent blockage of the initiation stage of carcinogenesis.	Flavonoids	0-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-52
20153368-7	2010	Moreover, a thorough investigation of the substrate specificity of flavonoids for the active site of CYP1 enzymes is undertaken.	Flavonoids	67-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	101-105
20153368-9	2010	Ultimately, the mode of flavonoid action, in terms of CYP1 inhibition or CYP1-mediated bioactivation, is dependent on the lipophilicity or hydrophilicity of each compound.	Flavonoids	24-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	54-58
20153368-9	2010	Ultimately, the mode of flavonoid action, in terms of CYP1 inhibition or CYP1-mediated bioactivation, is dependent on the lipophilicity or hydrophilicity of each compound.	Flavonoids	24-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-77
20157728-1	2010	Tobacco is a commonly used heterologous system for studying combinatorial regulation of the flavonoid biosynthetic pathway by the bHLH-MYB transcription factor (TF) complex in plants.	Flavonoids	92-101	myb-related protein 3R-1-like	Nicotiana tabacum	135-138
20112051-7	2010	The expression patterns of these genes were quantified in coloured reproductive organs throughout development, and correlated with anthocyanin accumulation and the expression profiles of the flavonoid-related MYBA1-2, UFGT, and ANR genes.	Flavonoids	191-200	MYBA1	Vitis vinifera	209-216
20096428-10	2010	A PAL gene (PAL6) was identified, and correlation analysis was compatible with PAL6 being an actively expressed gene with function in flavonoid synthesis.	Flavonoids	134-143	phenylalanine ammonia-lyase	Solanum lycopersicum	12-16
20096428-10	2010	A PAL gene (PAL6) was identified, and correlation analysis was compatible with PAL6 being an actively expressed gene with function in flavonoid synthesis.	Flavonoids	134-143	phenylalanine ammonia-lyase	Solanum lycopersicum	79-83
20157728-5	2010	NtAn2 shares high sequence homology with other known flavonoid-related MYB TFs and is mostly expressed in developing flowers.	Flavonoids	53-62	transcription factor MYB114-like	Nicotiana tabacum	0-5
20157728-5	2010	NtAn2 shares high sequence homology with other known flavonoid-related MYB TFs and is mostly expressed in developing flowers.	Flavonoids	53-62	myb-related protein 3R-1-like	Nicotiana tabacum	71-74
20157728-7	2010	In transgenic tobacco and Arabidopsis expressing NtAn2, both subsets of early and late flavonoid pathway genes are up-regulated.	Flavonoids	87-96	transcription factor MYB114-like	Nicotiana tabacum	49-54
20157728-11	2010	Transient co-expression of NtAn2 and Lc or Arabidopsis TT8 in tobacco protoplasts activated the promoters of two key flavonoid pathway genes, chalcone synthase and dihydroflavonol reductase.	Flavonoids	117-126	transcription factor MYB114-like	Nicotiana tabacum	27-32
20157728-11	2010	Transient co-expression of NtAn2 and Lc or Arabidopsis TT8 in tobacco protoplasts activated the promoters of two key flavonoid pathway genes, chalcone synthase and dihydroflavonol reductase.	Flavonoids	117-126	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	55-58
20079823-5	2010	[CM]), ECM (an ethanol extract of CM), and the abundant flavonoids apigenin and luteolin in CM on the oxidized LDL (oxLDL)-induced expression of ICAM-1 and E-selectin in human umbilical vein endothelial cells (HUVECs).	Flavonoids	56-66	intercellular adhesion molecule 1	Homo sapiens	145-151
20300638-5	2010	High performance liquid chromatography (HPLC) and mass spectrometry (MS) showed that quercetin was transformed into a compound with a mass identical to tamarixetin, suggesting that the flavonoid was methylated by catechol-O-methyl transferase (COMT) within platelets.	Flavonoids	185-194	catechol-O-methyltransferase	Homo sapiens	213-242
20300638-5	2010	High performance liquid chromatography (HPLC) and mass spectrometry (MS) showed that quercetin was transformed into a compound with a mass identical to tamarixetin, suggesting that the flavonoid was methylated by catechol-O-methyl transferase (COMT) within platelets.	Flavonoids	185-194	catechol-O-methyltransferase	Homo sapiens	244-248
19897037-8	2010	Cellular uptake of cyanidin was accompanied by an inhibition of multidrug resistance protein 1 (involved in cellular efflux of flavonoids) mRNA-levels indicating its gene-regulatory activity.	Flavonoids	127-137	ATP binding cassette subfamily B member 1	Homo sapiens	64-94
19195869-0	2010	Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells.	Flavonoids	6-16	mitogen-activated protein kinase 3	Homo sapiens	65-71
19735647-8	2010	CoMFA (Comparative Molecular Field Analysis) and CoMSIA (Comparative Molecular Similarity Indices Analysis) 3D-QSAR (three-Dimensional Quantitative Structure-Activity Relationship) modeling indicated that electrostatic and hydrophobic properties were the most influential for interactions between the flavonoids and hCNT1, while electrostatic, hydrophobic and hydrogen bond donor properties were predominate for interactions with hCNT2 and hCNT3.	Flavonoids	301-311	solute carrier family 28 member 1	Homo sapiens	316-321
20684240-5	2010	Although studied flavonoids display only a temperate furin inhibition, they may serve as a great potential for the future development of more potent non-peptide inhibitors against furin.	Flavonoids	17-27	furin, paired basic amino acid cleaving enzyme	Homo sapiens	53-58
20684240-5	2010	Although studied flavonoids display only a temperate furin inhibition, they may serve as a great potential for the future development of more potent non-peptide inhibitors against furin.	Flavonoids	17-27	furin, paired basic amino acid cleaving enzyme	Homo sapiens	180-185
20099825-0	2010	Dietary flavonoids activate the constitutive androstane receptor (CAR).	Flavonoids	8-18	nuclear receptor subfamily 1 group I member 3	Homo sapiens	32-64
20099825-0	2010	Dietary flavonoids activate the constitutive androstane receptor (CAR).	Flavonoids	8-18	nuclear receptor subfamily 1 group I member 3	Homo sapiens	66-69
20099825-8	2010	These results suggest that dietary flavonoids regulate CAR activity and thereby accelerate both detoxification and energy metabolism.	Flavonoids	35-45	nuclear receptor subfamily 1 group I member 3	Homo sapiens	55-58
20079507-6	2010	We also present evidence for the involvement of GSTs in the synthesis of sulfur-containing secondary metabolites such as volatiles and glucosinolates, and the conjugation, transport and storage of reactive oxylipins, phenolics and flavonoids.	Flavonoids	231-241	hematopoietic prostaglandin D synthase	Homo sapiens	48-52
20684240-2	2010	To identify a new class of small non-peptide inhibitors of furin we performed a study of several flavonoids and some natural products.	Flavonoids	97-107	furin, paired basic amino acid cleaving enzyme	Homo sapiens	59-64
20684240-3	2010	Glycosylated flavonoids: rutin, naringin, baikalin and methylhesperidin were shown to inhibit furin at pH 7.2 reversibly and competitively with Ki- 80-200 microM.	Flavonoids	13-23	furin, paired basic amino acid cleaving enzyme	Homo sapiens	94-99
20195824-4	2010	Five flavonoids were isolated from the ethanol extracts of licorice roots, using an in vitro DGAT inhibitory assay.	Flavonoids	5-15	diacylglycerol O-acyltransferase 1	Homo sapiens	93-97
20195824-5	2010	One isoprenyl flavonoid showed most potential inhibition of DGAT on five flavonoids (1-5).	Flavonoids	73-83	diacylglycerol O-acyltransferase 1	Homo sapiens	60-64
19735647-8	2010	CoMFA (Comparative Molecular Field Analysis) and CoMSIA (Comparative Molecular Similarity Indices Analysis) 3D-QSAR (three-Dimensional Quantitative Structure-Activity Relationship) modeling indicated that electrostatic and hydrophobic properties were the most influential for interactions between the flavonoids and hCNT1, while electrostatic, hydrophobic and hydrogen bond donor properties were predominate for interactions with hCNT2 and hCNT3.	Flavonoids	301-311	solute carrier family 28 member 2	Homo sapiens	430-435
19735647-8	2010	CoMFA (Comparative Molecular Field Analysis) and CoMSIA (Comparative Molecular Similarity Indices Analysis) 3D-QSAR (three-Dimensional Quantitative Structure-Activity Relationship) modeling indicated that electrostatic and hydrophobic properties were the most influential for interactions between the flavonoids and hCNT1, while electrostatic, hydrophobic and hydrogen bond donor properties were predominate for interactions with hCNT2 and hCNT3.	Flavonoids	301-311	solute carrier family 28 member 3	Homo sapiens	440-445
19940392-5	2010	Interestingly, the lungs of all the camels and tongues of two of the three animals showed high expressions of CYP1A1 mRNA, and this may indicate exposure to ligands of aryl hydrocarbon receptor such as environmental pollutants or flavonoids.	Flavonoids	230-240	cytochrome P450 1A1	Bos taurus	110-116
19887118-0	2010	Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin.	Flavonoids	94-103	CD63 molecule	Homo sapiens	32-36
19887118-0	2010	Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin.	Flavonoids	94-103	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	41-47
19195861-10	2010	These flavonoids modified the expression of cloudin 5 and occludin.	Flavonoids	6-16	occludin	Homo sapiens	58-66
19544374-0	2010	Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response.	Flavonoids	79-89	ATP binding cassette subfamily C member 2	Homo sapiens	64-68
19544374-0	2010	Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response.	Flavonoids	79-89	BCR pseudogene 1	Homo sapiens	70-74
20487199-1	2010	OBJECTIVES: We have investigated whether endoplasmic reticulum stress and Bcl-2 proteins were linked to the protective effect exerted by flavonoids on ischaemia/reperfusion-induced cardiac damage.	Flavonoids	137-147	BCL2, apoptosis regulator	Rattus norvegicus	74-79
20487199-4	2010	Flavonoid treatment significantly increased the expression level of the anti-apoptotic protein, Bcl-2, but decreased that of the proapoptotic protein, Bax.	Flavonoids	0-9	BCL2, apoptosis regulator	Rattus norvegicus	96-101
20487199-4	2010	Flavonoid treatment significantly increased the expression level of the anti-apoptotic protein, Bcl-2, but decreased that of the proapoptotic protein, Bax.	Flavonoids	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	151-154
20487199-5	2010	The flavonoids down-regulated the expression levels of endoplasmic reticulum stress proteins, glucose-regulated protein-78, activating transcription factor 6alpha, X-box binding protein 1, inositol-requiring protein-1, phosphor-eukaryotic initiation factor 2alpha, and C/EBP-homologous protein.	Flavonoids	4-14	activating transcription factor 6	Rattus norvegicus	124-162
20487199-5	2010	The flavonoids down-regulated the expression levels of endoplasmic reticulum stress proteins, glucose-regulated protein-78, activating transcription factor 6alpha, X-box binding protein 1, inositol-requiring protein-1, phosphor-eukaryotic initiation factor 2alpha, and C/EBP-homologous protein.	Flavonoids	4-14	X-box binding protein 1	Rattus norvegicus	164-187
20487199-5	2010	The flavonoids down-regulated the expression levels of endoplasmic reticulum stress proteins, glucose-regulated protein-78, activating transcription factor 6alpha, X-box binding protein 1, inositol-requiring protein-1, phosphor-eukaryotic initiation factor 2alpha, and C/EBP-homologous protein.	Flavonoids	4-14	DNA-damage inducible transcript 3	Rattus norvegicus	269-293
20139896-1	2010	AIM: To determine whether the flavonoid baicalin attenuates oxygen-glucose deprivation (OGD)-induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase (5-LOX) activation in PC12 cells.	Flavonoids	30-39	arachidonate 5-lipoxygenase	Rattus norvegicus	148-162
20139896-1	2010	AIM: To determine whether the flavonoid baicalin attenuates oxygen-glucose deprivation (OGD)-induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase (5-LOX) activation in PC12 cells.	Flavonoids	30-39	arachidonate 5-lipoxygenase	Rattus norvegicus	164-169
20095789-5	2010	Flavonoids are a large group of polyphenolic compounds that are able to interfere with xanthine oxidase and aldehyde oxidase function.	Flavonoids	0-10	aldehyde oxidase 1	Homo sapiens	108-124
20228421-2	2010	An enhancement of PON1 activity by dietary factors including flavonoids is therefore of interest.	Flavonoids	61-71	paraoxonase 1	Homo sapiens	18-22
19940392-5	2010	Interestingly, the lungs of all the camels and tongues of two of the three animals showed high expressions of CYP1A1 mRNA, and this may indicate exposure to ligands of aryl hydrocarbon receptor such as environmental pollutants or flavonoids.	Flavonoids	230-240	aryl hydrocarbon receptor	Camelus bactrianus	168-193
20487199-6	2010	CONCLUSIONS: This study suggested that the protective mechanisms of flavonoids included regulation of Bcl-2/Bax proteins as well as the endoplasmic reticulum stress proteins.	Flavonoids	68-78	BCL2, apoptosis regulator	Rattus norvegicus	102-107
19585468-7	2010	When compared with the CYP2C19 inhibitor fluvoxamine, the flavonoids under study were 50- to 750-fold less potent.	Flavonoids	58-68	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	23-30
20487199-6	2010	CONCLUSIONS: This study suggested that the protective mechanisms of flavonoids included regulation of Bcl-2/Bax proteins as well as the endoplasmic reticulum stress proteins.	Flavonoids	68-78	BCL2 associated X, apoptosis regulator	Rattus norvegicus	108-111
20976092-0	2010	Effects of Various Flavonoids on the alpha-Synuclein Fibrillation Process.	Flavonoids	19-29	synuclein alpha	Homo sapiens	37-52
20033231-0	2010	Response of wild-type and high pigment-1 tomato fruit to UV-B depletion: flavonoid profiling and gene expression.	Flavonoids	73-82	DNA damage-binding protein 1	Solanum lycopersicum	26-40
20033231-3	2010	In hp-1 peel, a twofold higher level of rutin and an earlier accumulation of flavonoids than in wild-type were observed, which correlated to the earlier activation of most flavonoid biosynthetic genes compared to wild-type.	Flavonoids	77-87	DNA damage-binding protein 1	Solanum lycopersicum	3-7
20033231-3	2010	In hp-1 peel, a twofold higher level of rutin and an earlier accumulation of flavonoids than in wild-type were observed, which correlated to the earlier activation of most flavonoid biosynthetic genes compared to wild-type.	Flavonoids	77-86	DNA damage-binding protein 1	Solanum lycopersicum	3-7
20033231-4	2010	In hp-1 flesh, flavonoid content was up to 8.5-fold higher than in wild-type and correlated to the higher transcript level of flavonoid genes compared to wild-type.	Flavonoids	15-24	DNA damage-binding protein 1	Solanum lycopersicum	3-7
20033231-4	2010	In hp-1 flesh, flavonoid content was up to 8.5-fold higher than in wild-type and correlated to the higher transcript level of flavonoid genes compared to wild-type.	Flavonoids	126-135	DNA damage-binding protein 1	Solanum lycopersicum	3-7
20033231-5	2010	In both tissues, the expression of flavonoid genes was correlated with the anticipated and/or enhanced activation of the light signal transduction genes: LeCOP1LIKE, LeCOP1 and LeHY5.	Flavonoids	35-44	transcription factor HY5	Solanum lycopersicum	177-182
19994890-0	2010	Anticancer effects of flavonoid derivatives isolated from Millettia reticulata Benth in SK-Hep-1 human hepatocellular carcinoma cells.	Flavonoids	22-31	DNL-type zinc finger	Homo sapiens	91-96
20976092-5	2010	In this study 48 flavonoids belonging to several classes with structures differing in the position of double bonds and ring substituents were tested for their ability to inhibit the fibrillation of alpha-synuclein in vitro.	Flavonoids	17-27	synuclein alpha	Homo sapiens	198-213
20976092-6	2010	A variety of flavonoids inhibited alpha-synuclein fibrillation, and most of the strong inhibitory flavonoids were also found to disaggregate preformed fibrils.	Flavonoids	13-23	synuclein alpha	Homo sapiens	34-49
20453498-9	2010	CONCLUSION: A flavonoid-rich diet is positively associated with PON1 arylesterase activity in diabetic foot patients.	Flavonoids	14-23	paraoxonase 1	Homo sapiens	64-68
19889640-3	2010	The phenothiazine family of compounds, as well as the flavonoid myricetin, was recently shown to inhibit Hsp70-ATPase activity, whereas members of the dihydropyrimidine family stimulated ATPase function.	Flavonoids	54-63	heat shock protein family A (Hsp70) member 4	Homo sapiens	105-110
19914244-0	2010	Structural activity relationship of flavonoids with estrogen-related receptor gamma.	Flavonoids	36-46	estrogen related receptor gamma	Homo sapiens	52-83
19914244-1	2010	In this study, we investigated the structural activity relationships (SARs) of flavonoids with estrogen-related receptor gamma (ERRgamma) and its coactivator peroxisome proliferators-activated receptor gamma coactivator-1alpha (PGC-1alpha).	Flavonoids	79-89	estrogen related receptor gamma	Homo sapiens	95-126
19914244-1	2010	In this study, we investigated the structural activity relationships (SARs) of flavonoids with estrogen-related receptor gamma (ERRgamma) and its coactivator peroxisome proliferators-activated receptor gamma coactivator-1alpha (PGC-1alpha).	Flavonoids	79-89	estrogen related receptor gamma	Homo sapiens	128-136
19914244-1	2010	In this study, we investigated the structural activity relationships (SARs) of flavonoids with estrogen-related receptor gamma (ERRgamma) and its coactivator peroxisome proliferators-activated receptor gamma coactivator-1alpha (PGC-1alpha).	Flavonoids	79-89	PPARG coactivator 1 alpha	Homo sapiens	228-238
19914085-4	2010	HbA-robinetin interaction was examined using both robinetin fluorescence and flavonoid-induced quenching of the protein tryptophan fluorescence.	Flavonoids	77-86	keratin 90, pseudogene	Homo sapiens	0-3
19703516-0	2010	Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway.	Flavonoids	0-10	bone morphogenetic protein 1	Homo sapiens	91-94
19703516-0	2010	Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway.	Flavonoids	0-10	catenin beta 1	Homo sapiens	103-115
20128045-1	2010	The present study investigated the effects of a flavonoid extract from Cynomorium songaricum on the swimming endurance of rats by measuring changes of free radical scavenging enzymes, such as CuZn-SOD (copper, zinc-superoxide dismutase) and GSH-px (glutathione peroxidase), and body weights.	Flavonoids	48-57	superoxide dismutase 1	Rattus norvegicus	192-200
20128045-3	2010	After treatment with the flavonoid extract at doses of 0.5, 1.0, and 2.0 g/kg body weight, the CuZn-SOD and GSH-px activities in swimming rats were increased by 1.4%, 3.3%, 4.1% and 112.2%, 208.7%, 261.7%, respectively, while the levels of MDA (malondialdehyde) were decreased by 64.7%, 79.4%, and 86.4% respectively.	Flavonoids	25-34	superoxide dismutase 1	Rattus norvegicus	95-103
19931462-2	2010	In this study, a series of flavonoids, many known to be inhibitors of Abeta fibril formation, were screened for their ability to inhibit RCM-kappa-CN fibrilisation, and the results were compared with literature data on Abeta inhibition.	Flavonoids	27-37	amyloid beta precursor protein	Homo sapiens	70-75
20930378-0	2010	Potent modification of inducible CYP1A1 expression by flavonoids.	Flavonoids	54-64	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	33-39
20930378-1	2010	The present study examined modifications of beta-naphthoflavone (beta-NF)-induced cytochrome P450 1A1 (CYP1A1) expression by flavonoids in mouse hepatocytes in primary culture.	Flavonoids	125-135	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	82-101
20930378-1	2010	The present study examined modifications of beta-naphthoflavone (beta-NF)-induced cytochrome P450 1A1 (CYP1A1) expression by flavonoids in mouse hepatocytes in primary culture.	Flavonoids	125-135	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	103-109
20930378-2	2010	Some flavonoids (apigenin, chrysin, flavone, flavanone, galangin, luteolin, and naringenin) by themselves induced CYP1A1 mRNA expression, especially flavone which was even more effective than beta-NF.	Flavonoids	5-15	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	114-120
20930378-6	2010	The present observations suggest the need to reveal the mechanism by which CYP1A1 expression is modified by flavonoids for risk assessment, since CYP1A1 activates environmental carcinogenic polycyclic hydrocarbons and flavonoids are major constituents in food.	Flavonoids	108-118	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	75-81
20930378-6	2010	The present observations suggest the need to reveal the mechanism by which CYP1A1 expression is modified by flavonoids for risk assessment, since CYP1A1 activates environmental carcinogenic polycyclic hydrocarbons and flavonoids are major constituents in food.	Flavonoids	108-118	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	146-152
20930378-6	2010	The present observations suggest the need to reveal the mechanism by which CYP1A1 expression is modified by flavonoids for risk assessment, since CYP1A1 activates environmental carcinogenic polycyclic hydrocarbons and flavonoids are major constituents in food.	Flavonoids	218-228	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	75-81
20460771-3	2010	In this study, we compared the inhibitory effects of other ARIs including flavonoids on AKR1B10 and aldose reductase to evaluate their specificity.	Flavonoids	74-84	aldo-keto reductase family 1 member B10	Homo sapiens	88-95
19931462-2	2010	In this study, a series of flavonoids, many known to be inhibitors of Abeta fibril formation, were screened for their ability to inhibit RCM-kappa-CN fibrilisation, and the results were compared with literature data on Abeta inhibition.	Flavonoids	27-37	amyloid beta precursor protein	Homo sapiens	219-224
19894226-0	2010	Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes.	Flavonoids	0-10	caspase 4	Homo sapiens	21-29
20645919-4	2010	In our previous work we studied modulation of MDR in cancer cells expressing P-gp or MRP1 by selected carotenoids, flavonoids and extracts from medically important Chinese plants.	Flavonoids	115-125	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
20645919-4	2010	In our previous work we studied modulation of MDR in cancer cells expressing P-gp or MRP1 by selected carotenoids, flavonoids and extracts from medically important Chinese plants.	Flavonoids	115-125	ATP binding cassette subfamily C member 1	Homo sapiens	85-89
20132735-4	2010	In this study, we observed that several flavonoids-kaempferol, quercetin, fisetin, and chrysin-inhibit LPS-induced IL-8 promoter activation in RAW 264.7 cells.	Flavonoids	40-50	chemokine (C-X-C motif) ligand 15	Mus musculus	115-119
19941471-13	2010	Among polyphenols, curcumin and some flavonoids such as myricetin and quercetin, have been identified as potential anticancer agents with a mechanism of action that may be mediated by the Trx system.	Flavonoids	37-47	thioredoxin	Homo sapiens	188-191
20877134-0	2010	Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.	Flavonoids	0-10	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	61-80
20877134-2	2010	To this purpose, the conversion of diclofenac to 4"-hydroxydiclofenac by human liver microsomes was used as a model assay for assessing the CYP2C9 inhibitory activity of these two flavonoids.	Flavonoids	180-190	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	140-146
19879672-0	2010	Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.	Flavonoids	22-32	butyrylcholinesterase	Homo sapiens	56-77
20814159-0	2010	Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils.	Flavonoids	50-59	glucuronidase beta	Homo sapiens	75-93
20814159-2	2010	Mammalian beta-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.	Flavonoids	122-131	glucuronidase beta	Homo sapiens	10-28
20814159-8	2010	In conclusion, we show that beta-glucuronidase from four different sources, including human neutrophils, is able to deconjugate flavonoid glucuronides and non-flavonoid substrates at fairly similar kinetic rates.	Flavonoids	128-137	glucuronidase beta	Homo sapiens	28-46
20814159-8	2010	In conclusion, we show that beta-glucuronidase from four different sources, including human neutrophils, is able to deconjugate flavonoid glucuronides and non-flavonoid substrates at fairly similar kinetic rates.	Flavonoids	159-168	glucuronidase beta	Homo sapiens	28-46
19879672-1	2010	Selected flavonoids: galangin, kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8).	Flavonoids	9-19	butyrylcholinesterase	Homo sapiens	131-152
19879672-1	2010	Selected flavonoids: galangin, kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8).	Flavonoids	9-19	butyrylcholinesterase	Homo sapiens	154-158
19879672-3	2010	The most potent BChE inhibitor among the tested flavonoids was galangin, which showed 12 times higher preference for binding to BChE (7 micromol/L) than to the related enzyme human acetylcholinesterase (AChE, EC 3.1.1.7).	Flavonoids	48-58	butyrylcholinesterase	Homo sapiens	16-20
19879672-3	2010	The most potent BChE inhibitor among the tested flavonoids was galangin, which showed 12 times higher preference for binding to BChE (7 micromol/L) than to the related enzyme human acetylcholinesterase (AChE, EC 3.1.1.7).	Flavonoids	48-58	butyrylcholinesterase	Homo sapiens	128-132
19879672-4	2010	Docking study showed that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions.	Flavonoids	26-36	butyrylcholinesterase	Homo sapiens	49-53
19879672-5	2010	The UV-VIS (200-500 nm) absorption spectra of the flavonoid phosphate buffer solution (pH 7.4), with the exception of rutin, revealed time dependant changes indicating precipitation of flavonoids or in the case of myricetin, a change in the chemical structure resulting in a BChE non-inhibiting specie.	Flavonoids	185-195	butyrylcholinesterase	Homo sapiens	275-279
19883715-5	2010	Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities.	Flavonoids	23-33	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	69-75
20136620-2	2010	In this study, the immunostimulatory and adjuvant properties of AcF1, a flavonoids-rich fraction of Alchornea cordifolia extract, was evaluated.	Flavonoids	72-82	albumin conformation factor 1	Mus musculus	64-68
19828881-5	2010	Therefore, we conducted a dioxin response element reporter-based screen to assess the AHR activity associated with a range of flavonoid compounds.	Flavonoids	126-135	aryl hydrocarbon receptor	Homo sapiens	86-89
19499569-1	2010	The purpose of this study was to investigate the in vitro and in vivo interactions between flavonoids and P-glycoprotein (P-gp) substrates.	Flavonoids	91-101	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	106-120
19499569-1	2010	The purpose of this study was to investigate the in vitro and in vivo interactions between flavonoids and P-glycoprotein (P-gp) substrates.	Flavonoids	91-101	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	122-126
19499569-2	2010	The inhibitory effects of flavonoids on P-gp were determined by accumulation studies in P-gp-overexpressing MCF-7/ADR cells using daunomycin (DNM) as a model substrate.	Flavonoids	26-36	phosphoglycolate phosphatase	Homo sapiens	40-44
19995827-3	2010	Mutant analysis demonstrates that the absence of FFT transcript affects flavonoid levels in the plant and that the altered flavonoid metabolism has wide-ranging consequences.	Flavonoids	72-81	detoxifying efflux carrier 35	Arabidopsis thaliana	49-52
19995827-6	2010	Thus, as well as adding FFT to the incompletely described flavonoid transport network, it is found that correct reproductive development in Arabidopsis is perturbed when this particular transporter is missing.	Flavonoids	58-67	detoxifying efflux carrier 35	Arabidopsis thaliana	24-27
19499569-2	2010	The inhibitory effects of flavonoids on P-gp were determined by accumulation studies in P-gp-overexpressing MCF-7/ADR cells using daunomycin (DNM) as a model substrate.	Flavonoids	26-36	phosphoglycolate phosphatase	Homo sapiens	88-92
19828881-6	2010	Our screen identified two flavonoids (5-methoxyflavone and 7,4"-dimethoxyisoflavone) with previously unidentified AHR agonist potential.	Flavonoids	26-36	aryl hydrocarbon receptor	Homo sapiens	114-117
20523105-1	2010	Silibinin, a flavonoid, is an inhibitor of P-glycoprotein (P-gp)-mediated efflux transporters, and its oxidative metabolism is catalyzed by CYP3A4.	Flavonoids	13-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	59-63
19693651-0	2010	Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway.	Flavonoids	12-21	mitogen-activated protein kinase 14	Homo sapiens	120-123
20358477-4	2010	These features were in concert with a time-dependent activation (starting at 15 min and maintained up to 18 h) of the AP-1/JNK pathway, which played an important role in the control of the cell death induced by the flavonoid and contributed to the regulation of survival/proliferation (AKT, ERK) and death (caspase-3, p38, unbalance of Bcl-2 proapoptotic and antiapoptotic proteins) signals.	Flavonoids	215-224	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-122
20358477-4	2010	These features were in concert with a time-dependent activation (starting at 15 min and maintained up to 18 h) of the AP-1/JNK pathway, which played an important role in the control of the cell death induced by the flavonoid and contributed to the regulation of survival/proliferation (AKT, ERK) and death (caspase-3, p38, unbalance of Bcl-2 proapoptotic and antiapoptotic proteins) signals.	Flavonoids	215-224	mitogen-activated protein kinase 8	Homo sapiens	123-126
20358477-4	2010	These features were in concert with a time-dependent activation (starting at 15 min and maintained up to 18 h) of the AP-1/JNK pathway, which played an important role in the control of the cell death induced by the flavonoid and contributed to the regulation of survival/proliferation (AKT, ERK) and death (caspase-3, p38, unbalance of Bcl-2 proapoptotic and antiapoptotic proteins) signals.	Flavonoids	215-224	AKT serine/threonine kinase 1	Homo sapiens	286-289
20358477-4	2010	These features were in concert with a time-dependent activation (starting at 15 min and maintained up to 18 h) of the AP-1/JNK pathway, which played an important role in the control of the cell death induced by the flavonoid and contributed to the regulation of survival/proliferation (AKT, ERK) and death (caspase-3, p38, unbalance of Bcl-2 proapoptotic and antiapoptotic proteins) signals.	Flavonoids	215-224	mitogen-activated protein kinase 1	Homo sapiens	291-294
20358477-4	2010	These features were in concert with a time-dependent activation (starting at 15 min and maintained up to 18 h) of the AP-1/JNK pathway, which played an important role in the control of the cell death induced by the flavonoid and contributed to the regulation of survival/proliferation (AKT, ERK) and death (caspase-3, p38, unbalance of Bcl-2 proapoptotic and antiapoptotic proteins) signals.	Flavonoids	215-224	caspase 3	Homo sapiens	307-316
20358477-4	2010	These features were in concert with a time-dependent activation (starting at 15 min and maintained up to 18 h) of the AP-1/JNK pathway, which played an important role in the control of the cell death induced by the flavonoid and contributed to the regulation of survival/proliferation (AKT, ERK) and death (caspase-3, p38, unbalance of Bcl-2 proapoptotic and antiapoptotic proteins) signals.	Flavonoids	215-224	mitogen-activated protein kinase 14	Homo sapiens	318-321
20358477-4	2010	These features were in concert with a time-dependent activation (starting at 15 min and maintained up to 18 h) of the AP-1/JNK pathway, which played an important role in the control of the cell death induced by the flavonoid and contributed to the regulation of survival/proliferation (AKT, ERK) and death (caspase-3, p38, unbalance of Bcl-2 proapoptotic and antiapoptotic proteins) signals.	Flavonoids	215-224	BCL2 apoptosis regulator	Homo sapiens	336-341
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Flavonoids	229-238	nuclear factor kappa B subunit 1	Homo sapiens	24-34
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Flavonoids	229-238	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Flavonoids	229-238	mitogen-activated protein kinase 8	Homo sapiens	164-167
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Flavonoids	229-238	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	168-172
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Flavonoids	229-238	nuclear factor kappa B subunit 1	Homo sapiens	202-212
20523105-1	2010	Silibinin, a flavonoid, is an inhibitor of P-glycoprotein (P-gp)-mediated efflux transporters, and its oxidative metabolism is catalyzed by CYP3A4.	Flavonoids	13-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	43-57
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Flavonoids	26-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	171-176
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Flavonoids	26-36	matrix metallopeptidase 9	Homo sapiens	196-201
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Flavonoids	26-36	small nucleolar RNA, C/D box 87	Homo sapiens	246-249
21117316-5	2010	The article discusses recent reports on the EpRE-mediated induction of NQO1 (NAD(P)H: quinone oxidoreductase) gene expression by the flavonoids (flavonols, flavones and flavan-3-oles) and the role of pro-oxidant properties of the flavonoids in the mechanism of this induction.	Flavonoids	230-240	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-75
21117316-5	2010	The article discusses recent reports on the EpRE-mediated induction of NQO1 (NAD(P)H: quinone oxidoreductase) gene expression by the flavonoids (flavonols, flavones and flavan-3-oles) and the role of pro-oxidant properties of the flavonoids in the mechanism of this induction.	Flavonoids	133-143	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-75
19906891-6	2010	Of 26 MYB and basic helix-loop-helix transcription factors putatively involved in regulating transcription of genes in the phenylpropanoid and/or flavonoid pathway, only the expression level of the MYB12 gene correlated well with the decrease in the expression of structural flavonoid genes in peel samples of pink- and red-fruited genotypes during ripening.	Flavonoids	146-155	Myb12 transcription factor	Solanum lycopersicum	198-203
19906891-6	2010	Of 26 MYB and basic helix-loop-helix transcription factors putatively involved in regulating transcription of genes in the phenylpropanoid and/or flavonoid pathway, only the expression level of the MYB12 gene correlated well with the decrease in the expression of structural flavonoid genes in peel samples of pink- and red-fruited genotypes during ripening.	Flavonoids	275-284	Myb12 transcription factor	Solanum lycopersicum	198-203
19906891-9	2010	In conclusion, biochemical and molecular data, gene mapping, segregation analysis, and virus-induced gene silencing experiments demonstrate that the MYB12 transcription factor plays an important role in regulating the flavonoid pathway in tomato fruit and suggest strongly that SlMYB12 is a likely candidate for the y mutation.	Flavonoids	218-227	Myb12 transcription factor	Solanum lycopersicum	149-154
19906891-9	2010	In conclusion, biochemical and molecular data, gene mapping, segregation analysis, and virus-induced gene silencing experiments demonstrate that the MYB12 transcription factor plays an important role in regulating the flavonoid pathway in tomato fruit and suggest strongly that SlMYB12 is a likely candidate for the y mutation.	Flavonoids	218-227	Myb12 transcription factor	Solanum lycopersicum	278-285
21117316-5	2010	The article discusses recent reports on the EpRE-mediated induction of NQO1 (NAD(P)H: quinone oxidoreductase) gene expression by the flavonoids (flavonols, flavones and flavan-3-oles) and the role of pro-oxidant properties of the flavonoids in the mechanism of this induction.	Flavonoids	133-143	crystallin zeta	Homo sapiens	86-108
21117316-5	2010	The article discusses recent reports on the EpRE-mediated induction of NQO1 (NAD(P)H: quinone oxidoreductase) gene expression by the flavonoids (flavonols, flavones and flavan-3-oles) and the role of pro-oxidant properties of the flavonoids in the mechanism of this induction.	Flavonoids	230-240	crystallin zeta	Homo sapiens	86-108
20019811-0	2009	Fruit-surface flavonoid accumulation in tomato is controlled by a SlMYB12-regulated transcriptional network.	Flavonoids	14-23	Myb12 transcription factor	Solanum lycopersicum	66-73
19766177-0	2009	CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells.	Flavonoids	40-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
19766177-0	2009	CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells.	Flavonoids	40-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-17
19766177-3	2009	Since large doses of flavonoids can be encountered in the intestine simultaneously with ingested drugs and pollutants, this study aimed at investigating nine individual flavonoid compounds and their interactions with the major intestinal isoforms of cytochrome P450, i.e.	Flavonoids	21-31	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	250-268
19766177-3	2009	Since large doses of flavonoids can be encountered in the intestine simultaneously with ingested drugs and pollutants, this study aimed at investigating nine individual flavonoid compounds and their interactions with the major intestinal isoforms of cytochrome P450, i.e.	Flavonoids	21-30	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	250-268
19772910-13	2009	At a higher dose, Cyp2a, Cyp2b, and Cyp3a could be induced and the male-specific induction of Cyp2a and Cyp3a was associated with the presence of prenylated flavonoids.	Flavonoids	157-167	cytochrome P450, family 2, subfamily a	Mus musculus	94-99
19772910-13	2009	At a higher dose, Cyp2a, Cyp2b, and Cyp3a could be induced and the male-specific induction of Cyp2a and Cyp3a was associated with the presence of prenylated flavonoids.	Flavonoids	157-167	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	104-109
19251944-2	2009	The present study reports that quercetin (a flavonoid) stimulated bumetanide-sensitive Cl(-) secretion with reduction of apical Cl(-) conductance, suggesting that quercetin stimulates Cl(-) secretion by activating an entry step of Cl(-) across the basolateral membrane through Na(+)/K(+)/2Cl(-) cotransporter (NKCC1).	Flavonoids	44-53	solute carrier family 12 member 2	Homo sapiens	310-315
19798679-3	2009	In the present study, we investigated the regulatory mechanisms by which quercetin, a flavonoid, induces the expression of the GCLC gene in rat pancreatic beta-cell line INS-1.	Flavonoids	86-95	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	127-131
19766327-0	2009	Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism.	Flavonoids	0-10	Janus kinase 2	Homo sapiens	49-53
19766327-0	2009	Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism.	Flavonoids	0-10	signal transducer and activator of transcription 3	Homo sapiens	54-59
19766327-0	2009	Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism.	Flavonoids	0-10	interleukin 6	Homo sapiens	80-84
20162352-3	2009	In the present study, we investigated the effects of luteolin, a flavonoid, on the regulation of receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis, functions and signaling pathway.	Flavonoids	65-74	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	97-147
20162352-3	2009	In the present study, we investigated the effects of luteolin, a flavonoid, on the regulation of receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis, functions and signaling pathway.	Flavonoids	65-74	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	149-154
19887540-0	2009	Arabidopsis NAC transcription factor, ANAC078, regulates flavonoid biosynthesis under high-light.	Flavonoids	57-66	NAC domain containing protein 2	Arabidopsis thaliana	38-45
19887540-7	2009	Interestingly, the transcript levels of some genes related to flavonoid biosynthesis and the levels of anthocyanins were significantly increased in Ox-ANAC078 plants and reduced in knockout ANAC078 plants (KO-ANAC078) compared with wild-type plants under HL stress.	Flavonoids	62-71	NAC domain containing protein 2	Arabidopsis thaliana	151-158
19887540-7	2009	Interestingly, the transcript levels of some genes related to flavonoid biosynthesis and the levels of anthocyanins were significantly increased in Ox-ANAC078 plants and reduced in knockout ANAC078 plants (KO-ANAC078) compared with wild-type plants under HL stress.	Flavonoids	62-71	NAC domain containing protein 2	Arabidopsis thaliana	190-197
19887540-7	2009	Interestingly, the transcript levels of some genes related to flavonoid biosynthesis and the levels of anthocyanins were significantly increased in Ox-ANAC078 plants and reduced in knockout ANAC078 plants (KO-ANAC078) compared with wild-type plants under HL stress.	Flavonoids	62-71	NAC domain containing protein 2	Arabidopsis thaliana	190-197
19887540-8	2009	The present findings suggest that ANAC078 protein is associated with the induction of genes related to flavonoid biosynthesis, leading to the accumulation of anthocyanins, in response to HL stress.	Flavonoids	103-112	NAC domain containing protein 2	Arabidopsis thaliana	34-41
32038836-10	2009	Combination of ML-7 with flavonoids increased the anticancer effect of ML-7 to a greater extent than combination with the anticancer drugs.	Flavonoids	25-35	solute carrier family 25 member 16	Homo sapiens	71-75
19604541-0	2009	The effects of twelve representative flavonoids on tissue factor expression in human monocytes: structure-activity relationships.	Flavonoids	37-47	coagulation factor III, tissue factor	Homo sapiens	51-64
19854181-0	2009	Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation.	Flavonoids	25-34	mitogen-activated protein kinase 8	Homo sapiens	107-110
19814731-1	2009	BACKGROUND AND PURPOSE: The modulation by flavonoids of platelet responses induced by thrombin has been little investigated, and the antiplatelet activity, as well as possible inhibitory mechanisms of these compounds on thrombin signalling, has not yet been elucidated.	Flavonoids	42-52	coagulation factor II, thrombin	Homo sapiens	86-94
19881301-1	2009	Interleukin (IL)-4 has been suggested as a molecular therapeutic target to prevent and/or treat various allergic diseases and several flavonoids have been suggested as anti-allergic agents suppressing IL-4 production.	Flavonoids	134-144	interleukin 4	Mus musculus	201-205
19881301-2	2009	In an effort to find novel candidates for anti-allergic agents from natural sources, we screened several flavonoids affecting on IL-4 production.	Flavonoids	105-115	interleukin 4	Mus musculus	129-133
19670328-0	2009	Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB.	Flavonoids	19-28	TNF receptor superfamily member 25	Homo sapiens	98-101
19603495-0	2009	Spectroscopic and molecular modeling studies on the binding of the flavonoid luteolin and human serum albumin.	Flavonoids	67-76	albumin	Homo sapiens	96-109
19814731-2	2009	We explored whether flavonoids affect platelet signalling pathways triggered by thrombin and by the selective activation of its protease-activated receptors (PARs) 1 and 4, and analysed the antagonism of these polyphenols at thrombin receptors.	Flavonoids	20-30	coagulation factor II, thrombin	Homo sapiens	80-88
19814731-4	2009	The ability of these flavonoids to bind to thrombin receptors was investigated by competitive radioligand binding assays using (125)I-thrombin.	Flavonoids	21-31	coagulation factor II, thrombin	Homo sapiens	43-51
19814731-4	2009	The ability of these flavonoids to bind to thrombin receptors was investigated by competitive radioligand binding assays using (125)I-thrombin.	Flavonoids	21-31	coagulation factor II, thrombin	Homo sapiens	134-142
19017364-2	2009	The bioflavonoid quercetin inhibits HSP70 expression and induces cancer cells apoptosis.	Flavonoids	4-16	heat shock protein family A (Hsp70) member 4	Homo sapiens	36-41
19793184-0	2009	Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.	Flavonoids	12-21	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	70-78
19793184-0	2009	Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.	Flavonoids	12-21	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	83-91
19663742-2	2009	The current review covers the findings on the relationships between flavonoid structural properties and their glucuronidation activities in in vivo trials and in vitro human UGTs or microsomes for the past 2 decades.	Flavonoids	68-77	EH domain containing 2	Homo sapiens	201-207
19017364-12	2009	These findings indicate that combinational administration of flavonoids capable of suppressing HSP70 and GRP78 such as quercetin and EGCG might represent a novel approach for cancer therapy or chemoprevention.	Flavonoids	61-71	heat shock protein family A (Hsp70) member 4	Homo sapiens	95-100
19017364-12	2009	These findings indicate that combinational administration of flavonoids capable of suppressing HSP70 and GRP78 such as quercetin and EGCG might represent a novel approach for cancer therapy or chemoprevention.	Flavonoids	61-71	heat shock protein family A (Hsp70) member 5	Homo sapiens	105-110
19666078-0	2009	CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.	Flavonoids	52-62	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-4
19933203-5	2009	Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production.	Flavonoids	192-201	phosphatidic acid phosphatase 1	Arabidopsis thaliana	135-139
19933203-5	2009	Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production.	Flavonoids	192-201	Purple acid phosphatases superfamily protein	Arabidopsis thaliana	144-148
19596285-0	2009	Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies.	Flavonoids	45-54	butyrylcholinesterase	Homo sapiens	0-14
19736994-8	2009	In conclusion, efflux transporters Mrp2 and Bcrp1 are shown to compensate for each other and enable the intestinal excretion of flavonoid (i.e., naringenin) glucuronides.	Flavonoids	128-137	ATP binding cassette subfamily C member 2	Rattus norvegicus	35-39
19736994-8	2009	In conclusion, efflux transporters Mrp2 and Bcrp1 are shown to compensate for each other and enable the intestinal excretion of flavonoid (i.e., naringenin) glucuronides.	Flavonoids	128-137	ATP binding cassette subfamily G member 2	Rattus norvegicus	44-49
19703423-7	2009	Our data suggest that in a heterologous host, AtCPC acts as a repressor of anthocyanin production, from which a new evidence for better understanding of the transcriptional regulation of flavonoid biosynthesis and, an implication for the development of new varieties of tobacco and other commercially important ornamental plants are provided.	Flavonoids	187-196	Homeodomain-like superfamily protein	Arabidopsis thaliana	46-51
19666078-8	2009	Taken together the data suggests that CYP1 family enzymes enhance the antiproliferative activity of dietary flavonoids in breast cancer cells, through bioconversion to more active products.	Flavonoids	108-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	38-42
19666078-1	2009	Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored.	Flavonoids	91-101	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	152-156
19666078-2	2009	In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated.	Flavonoids	44-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	129-135
19666078-2	2009	In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated.	Flavonoids	44-54	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	137-143
19666078-2	2009	In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated.	Flavonoids	44-54	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	148-154
19743802-8	2009	To examine the reactivity of the catechol type polyphenols, such as flavonoids, to endogenous beta-actin, RL34 cells were coexposed to Bio-DPA and the flavonoids quercetin, (-)-epicatechin, and (-)-epicatechin gallate.	Flavonoids	68-78	POTE ankyrin domain family member F	Homo sapiens	94-104
19666002-2	2009	Procyanidins (Pcy) are oligomeric and polymeric flavonoids formed by catechins and epicatechins monomers trigger apoptosis by activating TRAIL-death receptors in human colon adenocarcinoma SW480 cells.	Flavonoids	48-58	TNF superfamily member 10	Homo sapiens	137-142
19686719-0	2009	The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue.	Flavonoids	4-13	protein kinase cGMP-dependent 1	Homo sapiens	138-141
19743802-9	2009	Upon exposure of the cells to Bio-DPA in the presence of the flavonoids, we observed a significant decrease in the DPA-modified beta-actin.	Flavonoids	61-71	POTE ankyrin domain family member F	Homo sapiens	128-138
19865538-2	2009	An enhancement of PON2 activity by dietary factors including flavonoids is therefore of interest.	Flavonoids	61-71	paraoxonase 2	Homo sapiens	18-22
19592617-3	2009	The citrus-derived flavonoid, naringenin, has lipid-lowering properties and inhibits VLDL secretion from cultured hepatocytes in a manner resembling insulin.	Flavonoids	19-28	CD320 antigen	Mus musculus	85-89
19820189-1	2009	Two dominant alleles of the I locus in Glycine max silence nine chalcone synthase (CHS) genes to inhibit function of the flavonoid pathway in the seed coat.	Flavonoids	121-130	chalcone synthase	Glycine max	64-81
19820189-1	2009	Two dominant alleles of the I locus in Glycine max silence nine chalcone synthase (CHS) genes to inhibit function of the flavonoid pathway in the seed coat.	Flavonoids	121-130	chalcone synthase	Glycine max	83-86
19690377-1	2009	Together with leucoanthocyanidin reductase, anthocyanidin reductase (ANR) is one of the two enzymes of the flavonoid-biosynthesis pathway that produces the flavan-3-ol monomers required for the formation of proanthocyanidins or condensed tannins.	Flavonoids	107-116	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	19-42
19692250-0	2009	Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.	Flavonoids	36-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
19692250-1	2009	A new series of flavonoid derivatives have been designed, synthesized and evaluated as potent AChE inhibitors.	Flavonoids	16-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98
19725578-2	2009	Flavonoid dimers bearing five or six ethylene glycol (EG) units with 6-methyl (4e, 4f) or 7-methyl (5e, 5f) substitution on the ring A of flavonoid dimers have the highest modulating activity for DOX against MRP1 with an EC(50) ranging from 73 to 133 nM.	Flavonoids	0-9	ATP binding cassette subfamily C member 1	Homo sapiens	208-212
19725578-3	2009	At 0.5 microM, the flavonoid dimer 4e was sufficient to restore DOX accumulation in 2008/MRP1 to parental 2008/P level.	Flavonoids	19-28	ATP binding cassette subfamily C member 1	Homo sapiens	89-93
19725578-5	2009	Our data suggest that flavonoid dimers have a high affinity toward binding to DOX recognition site of MRP1.	Flavonoids	22-31	ATP binding cassette subfamily C member 1	Homo sapiens	102-106
19725578-7	2009	The present study demonstrates that flavonoid dimers can be employed as an effective modulator of MRP1-mediated drug resistance in cancer cells.	Flavonoids	36-45	ATP binding cassette subfamily C member 1	Homo sapiens	98-102
19652996-1	2009	UDP-galactose:flavonoid 3-O-galactosyltransferase (UFGalT) is responsible for cyanidin 3-galactoside (cy3-gal) synthesis from cyanidin (cy) and UDP-galactose (UDP-gal) which are, respectively, catalyzed by anthocyanidin synthase (ANS) and UDP-glucose 4-epimerase (UGE).	Flavonoids	14-23	bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1	Malus domestica	239-262
19652996-1	2009	UDP-galactose:flavonoid 3-O-galactosyltransferase (UFGalT) is responsible for cyanidin 3-galactoside (cy3-gal) synthesis from cyanidin (cy) and UDP-galactose (UDP-gal) which are, respectively, catalyzed by anthocyanidin synthase (ANS) and UDP-glucose 4-epimerase (UGE).	Flavonoids	14-23	bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1	Malus domestica	264-267
19690377-1	2009	Together with leucoanthocyanidin reductase, anthocyanidin reductase (ANR) is one of the two enzymes of the flavonoid-biosynthesis pathway that produces the flavan-3-ol monomers required for the formation of proanthocyanidins or condensed tannins.	Flavonoids	107-116	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	69-72
19634918-0	2009	Molecular mechanisms underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation.	Flavonoids	36-45	synuclein alpha	Homo sapiens	68-83
19634918-1	2009	The molecular mechanism underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation was thoroughly examined by various biochemical and biophysical approaches.	Flavonoids	39-48	synuclein alpha	Homo sapiens	71-86
19634918-2	2009	The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of soluble flavonoid-modified species of alpha-synuclein (monomers and oligomers).	Flavonoids	42-52	synuclein alpha	Homo sapiens	56-71
19634918-2	2009	The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of soluble flavonoid-modified species of alpha-synuclein (monomers and oligomers).	Flavonoids	42-52	synuclein alpha	Homo sapiens	280-295
19634918-2	2009	The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of soluble flavonoid-modified species of alpha-synuclein (monomers and oligomers).	Flavonoids	42-51	synuclein alpha	Homo sapiens	56-71
19634918-2	2009	The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of soluble flavonoid-modified species of alpha-synuclein (monomers and oligomers).	Flavonoids	42-51	synuclein alpha	Homo sapiens	280-295
19634918-2	2009	The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of soluble flavonoid-modified species of alpha-synuclein (monomers and oligomers).	Flavonoids	109-118	synuclein alpha	Homo sapiens	280-295
19634918-3	2009	All of these factors rather than a single one contribute to the inhibition of WT alpha-synuclein fibrillation induced by the flavonoid.	Flavonoids	125-134	synuclein alpha	Homo sapiens	81-96
19634918-4	2009	The structural requirements that appear necessary to provide a flavonoid the ability to inhibit alpha-synuclein fibrillation were determined to be vicinal dihydroxyphenyl moieties, irrespective of the ring position where they are located.	Flavonoids	63-72	synuclein alpha	Homo sapiens	96-111
19634918-5	2009	Flavonoids with three vicinal hydroxyl groups exhibited enhanced inhibitory effects on alpha-synuclein fibrillation.	Flavonoids	0-10	synuclein alpha	Homo sapiens	87-102
19634918-6	2009	The antioxidant activities of flavonoids were generally correlated with their in vitro inhibitory effects on alpha-synuclein fibrillation.	Flavonoids	30-40	synuclein alpha	Homo sapiens	109-124
19634918-7	2009	The flavonoids inhibiting alpha-synuclein fibrillation and stabilizing the protein monomeric conformation can serve as a model for the development of therapeutic drugs in combating Parkinson"s disease.	Flavonoids	4-14	synuclein alpha	Homo sapiens	26-41
19739602-0	2009	Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux.	Flavonoids	18-27	ATP binding cassette subfamily B member 1	Homo sapiens	58-72
19737984-0	2009	The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism.	Flavonoids	20-32	protein tyrosine kinase 2	Homo sapiens	93-114
19737984-0	2009	The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism.	Flavonoids	20-32	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
19621239-4	2009	Several structural genes of flavonoid metabolism including CHS (chalcone synthase), FLS1 (flavonol synthase 1) and ANS (anthocyanidin synthase) were induced in response to nitrogen depletion in wild type as well as in the egl3 and gl3 mutants.	Flavonoids	28-37	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	223-226
19501160-6	2009	Shape parameters and hydrophobicity were revealed to be major physicochemical parameters responsible for the inhibition activity of flavonoid derivatives and synthetic analogs towards ABCG2, whereas hydrogen-bond donor capacity appeared highly unfavorable.	Flavonoids	132-141	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	184-189
20387645-3	2009	The effects of the flavonoids on the cell cycle patterns and activation of caspase-3 were also examined.	Flavonoids	19-29	caspase 3	Homo sapiens	75-84
20387645-5	2009	At concentrations corresponding to ED50, the flavonoids mentioned above exerted varying degrees of caspase-3 activation in MT-4 cells.	Flavonoids	45-55	caspase 3	Homo sapiens	99-108
19621239-4	2009	Several structural genes of flavonoid metabolism including CHS (chalcone synthase), FLS1 (flavonol synthase 1) and ANS (anthocyanidin synthase) were induced in response to nitrogen depletion in wild type as well as in the egl3 and gl3 mutants.	Flavonoids	28-37	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	64-81
19621239-4	2009	Several structural genes of flavonoid metabolism including CHS (chalcone synthase), FLS1 (flavonol synthase 1) and ANS (anthocyanidin synthase) were induced in response to nitrogen depletion in wild type as well as in the egl3 and gl3 mutants.	Flavonoids	28-37	flavonol synthase 1	Arabidopsis thaliana	84-88
19621239-4	2009	Several structural genes of flavonoid metabolism including CHS (chalcone synthase), FLS1 (flavonol synthase 1) and ANS (anthocyanidin synthase) were induced in response to nitrogen depletion in wild type as well as in the egl3 and gl3 mutants.	Flavonoids	28-37	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	120-142
19621239-4	2009	Several structural genes of flavonoid metabolism including CHS (chalcone synthase), FLS1 (flavonol synthase 1) and ANS (anthocyanidin synthase) were induced in response to nitrogen depletion in wild type as well as in the egl3 and gl3 mutants.	Flavonoids	28-37	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	222-226
19631328-6	2009	An addition of methanol modifier (30%, v/v) into 10 mM borate buffer (pH 9.55 for MEP; pH 10.0 for MES) was necessary to accomplish a baseline separation of nine flavonoids in the MEP and MES capillaries.	Flavonoids	162-172	neurolysin	Homo sapiens	180-183
19617894-0	2009	Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids.	Flavonoids	105-118	matrix metallopeptidase 3	Homo sapiens	14-19
19617894-2	2009	In this study, flavonoids from vegetables and fruits, such as quercetin, kaempferol, genistein, genistin, and daidzein, were tested for their ability to modulate the secretion and activity of MMP-3 in the MDA-MB-231 breast cancer cell line.	Flavonoids	15-25	matrix metallopeptidase 3	Homo sapiens	192-197
19443236-0	2009	Screening and structural characterization of alpha-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MS(n) and SORI-CID FTICR MS.	Flavonoids	93-103	sucrase-isomaltase	Homo sapiens	45-62
19596200-2	2009	The flavonoids were found to suppress the degranulation from Ag-stimulated RBL-2H3 cells to different extents.	Flavonoids	4-14	RB transcriptional corepressor like 2	Rattus norvegicus	75-80
19596200-3	2009	To disclose the inhibitory mechanism of degranulation by flavonoids, we examined their effects on the intracellular free Ca(2+) concentration ([Ca(2+)]i) and the intracellular signaling pathway such as Lyn, Syk, and PLCgammas.	Flavonoids	57-67	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	202-205
19596200-6	2009	It was thus suggested that suppression of Ag-stimulated degranulation by the flavonoids is mainly due to suppression of [Ca(2+)]i elevation and Syk activation.	Flavonoids	77-87	spleen associated tyrosine kinase	Rattus norvegicus	144-147
19215233-0	2009	Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers.	Flavonoids	27-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-75
19601638-1	2009	Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer.	Flavonoids	0-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-117
19596314-3	2009	At concentrations ranging from physiological to supraphysiological (3.7-370 muM), flavonoids, including genistein, have been shown to reduce the infectivity of a variety of viruses affecting humans and animals, including adenovirus, herpes simplex virus, human immunodeficiency virus, porcine reproductive and respiratory syndrome virus, and rotavirus.	Flavonoids	82-92	latexin	Homo sapiens	76-79
19601638-1	2009	Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer.	Flavonoids	0-10	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	122-128
19214356-0	2009	Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene.	Flavonoids	0-10	intercellular adhesion molecule 1	Homo sapiens	27-60
19557821-3	2009	Our results show that all flavonoids significantly inhibited HG-induced expression of proinflammatory genes and proteins, including TNF-alpha, interleukin-1beta (IL-1beta), and cyclooxygenase (COX)-2, at a concentration of 20 microM.	Flavonoids	26-36	tumor necrosis factor	Homo sapiens	132-141
19557821-3	2009	Our results show that all flavonoids significantly inhibited HG-induced expression of proinflammatory genes and proteins, including TNF-alpha, interleukin-1beta (IL-1beta), and cyclooxygenase (COX)-2, at a concentration of 20 microM.	Flavonoids	26-36	interleukin 1 beta	Homo sapiens	143-160
19557821-3	2009	Our results show that all flavonoids significantly inhibited HG-induced expression of proinflammatory genes and proteins, including TNF-alpha, interleukin-1beta (IL-1beta), and cyclooxygenase (COX)-2, at a concentration of 20 microM.	Flavonoids	26-36	interleukin 1 beta	Homo sapiens	162-170
19557821-3	2009	Our results show that all flavonoids significantly inhibited HG-induced expression of proinflammatory genes and proteins, including TNF-alpha, interleukin-1beta (IL-1beta), and cyclooxygenase (COX)-2, at a concentration of 20 microM.	Flavonoids	26-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-199
19557821-6	2009	In addition, we found for the first time that lower levels of Bcl-2 protein under HG conditions could be countered by the action of flavonoids.	Flavonoids	132-142	BCL2 apoptosis regulator	Homo sapiens	62-67
19707521-1	2009	Three major flavonoid chamomile components (quercetin, apigenin-7-O-glucoside and rutin) were subjected to oxidative metabolism by cytochrome P-450 of rat liver microsomal preparations.	Flavonoids	12-21	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-147
19214356-4	2009	This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1.	Flavonoids	39-49	intercellular adhesion molecule 1	Homo sapiens	83-89
19567393-4	2009	We investigated the effect of these flavonoids on PGE(2) production and COX-2 expression by LPS-activated RAW264.7 cells.	Flavonoids	36-46	toll-like receptor 4	Mus musculus	92-95
19563207-0	2009	Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.	Flavonoids	71-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	40-59
19563207-5	2009	Among 14 flavonoids examined, 3,5,7-trihydroxyflavone and 4"-methoxy- and 3",4"-dimethoxy-5,7-dihydroxyflavone were more active than flavone in interacting with P450 1B1, but the respective 7,8-dihydroxyflavones were less active.	Flavonoids	9-19	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	161-169
19401153-4	2009	Red wine extract (RWE) and quercetin, which is a major flavonoid present in red wine, inhibited significantly the TNF-alpha-induced upregulation of MMP-9 and cell migration, whereas resveratrol did not have significant inhibitory effects.	Flavonoids	55-64	tumor necrosis factor	Homo sapiens	114-123
19601883-3	2009	Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca(+2)-ATPase, lipoxygenase, cycloxygenase, etc.	Flavonoids	0-10	aldo-keto reductase family 1 member B	Homo sapiens	84-100
19194971-6	2009	However, this flavonoid induces the activation of p38/MAPK, leading to the pro-apoptotic caspase-3 activation and to the poly(ADP-ribose) polymerase cleavage only in the presence of ERalpha.	Flavonoids	14-23	mitogen-activated protein kinase 14	Homo sapiens	50-53
19759815-1	2009	Abyssinones and related flavonoids were screened against 3 enzymes (3betaHSD, 17betaHSD and Aromatase) of steroidogenesis pathway.	Flavonoids	24-34	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	78-101
19371329-12	2009	CONCLUSIONS AND IMPLICATIONS: This is the first report on a flavonoid compound (DiOHF) that is a potent FAK inhibitor.	Flavonoids	60-69	PTK2 protein tyrosine kinase 2	Mus musculus	104-107
19548210-1	2009	The chromatographic behavior of some flavonoids was established by RP-HPLC on RP-18 (LiChroCART, LiChrosphere RP-18e), RP-8 (Zorbax, Eclipse XDB-C8), CN (Saulentechnik, LiChrosphere CN100) columns.	Flavonoids	37-47	pre-mRNA processing factor 3	Homo sapiens	78-83
19548210-1	2009	The chromatographic behavior of some flavonoids was established by RP-HPLC on RP-18 (LiChroCART, LiChrosphere RP-18e), RP-8 (Zorbax, Eclipse XDB-C8), CN (Saulentechnik, LiChrosphere CN100) columns.	Flavonoids	37-47	programmed cell death 2	Homo sapiens	119-123
19194971-6	2009	However, this flavonoid induces the activation of p38/MAPK, leading to the pro-apoptotic caspase-3 activation and to the poly(ADP-ribose) polymerase cleavage only in the presence of ERalpha.	Flavonoids	14-23	estrogen receptor 1	Homo sapiens	182-189
19424633-0	2009	Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation.	Flavonoids	26-35	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	131-135
19492112-3	2009	The rcd1-1 mutant exhibits less accumulation of TT dimers, increased hypocotyl growth inhibition and higher accumulation of flavonoids under supplemental UV-B radiation.	Flavonoids	124-134	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	4-8
19292976-2	2009	The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2.	Flavonoids	4-13	myeloperoxidase	Mus musculus	49-64
19264971-0	2009	Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities.	Flavonoids	15-25	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	49-76
19264971-0	2009	Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities.	Flavonoids	15-25	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	78-81
19264971-9	2009	In conclusion, flavonoids are efficiently metabolized by UGT1A-deficient Gunn rats because of compensatory up-regulation of intestinal UGT2Bs and hepatic anion efflux transporters, which increases their disposition and limits their oral bioavailabilities.	Flavonoids	15-25	Ugt1a@	Rattus norvegicus	57-62
19470239-0	2009	Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells.	Flavonoids	22-32	tumor necrosis factor	Homo sapiens	36-45
19470239-0	2009	Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells.	Flavonoids	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	Flavonoids	44-54	tumor necrosis factor	Homo sapiens	116-125
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	Flavonoids	44-54	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
19470239-3	2009	In addition, phosphorylation and degradation of IkappaBalpha and translocation of NF-kappaB p65 were inhibited by these flavonoids in TNF-alpha-stimulated HEK 293 cells.	Flavonoids	120-130	NFKB inhibitor alpha	Homo sapiens	48-60
19470239-3	2009	In addition, phosphorylation and degradation of IkappaBalpha and translocation of NF-kappaB p65 were inhibited by these flavonoids in TNF-alpha-stimulated HEK 293 cells.	Flavonoids	120-130	RELA proto-oncogene, NF-kB subunit	Homo sapiens	82-95
19470239-3	2009	In addition, phosphorylation and degradation of IkappaBalpha and translocation of NF-kappaB p65 were inhibited by these flavonoids in TNF-alpha-stimulated HEK 293 cells.	Flavonoids	120-130	tumor necrosis factor	Homo sapiens	134-143
19470239-4	2009	Furthermore, generation of reactive oxygen species (ROS) in response to TNF-alpha was reduced by the flavonoids.	Flavonoids	101-111	tumor necrosis factor	Homo sapiens	72-81
19292976-2	2009	The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2.	Flavonoids	4-13	interleukin 6	Mus musculus	126-130
19292976-2	2009	The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2.	Flavonoids	4-13	tumor necrosis factor	Mus musculus	132-141
19292976-2	2009	The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2.	Flavonoids	4-13	interleukin 1 beta	Mus musculus	143-151
19292976-2	2009	The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2.	Flavonoids	4-13	chemokine (C-C motif) ligand 3	Mus musculus	153-163
19292976-2	2009	The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2.	Flavonoids	4-13	chemokine (C-X-C motif) ligand 2	Mus musculus	168-173
19321592-9	2009	The PARP-1-inhibiting flavonoids fisetin and tricetin were able to attenuate LPS-induced cytokine release from leukocytes of patients with chronic systemic inflammation, indicating a potential application as nutraceutical agents for these patient groups.	Flavonoids	22-32	poly(ADP-ribose) polymerase 1	Homo sapiens	4-10
19117929-0	2009	The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression.	Flavonoids	4-13	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
19366194-5	2009	The proposed MPSOCART was applied to predict the bioactivities of flavonoid derivatives and inhibitory activities of inhibitors of epidermal growth factor receptor tyrosine kinase, compared with partial least-squares and CART induced by greedy recursive partitioning.	Flavonoids	66-75	CART prepropeptide	Homo sapiens	17-21
19651800-3	2009	For example, butylated hydroxytoluene can prevent production of O2*- in mitochondria, whereas flavonoids can induce expression of antioxidant enzymes, SOD and catalase.	Flavonoids	94-104	superoxide dismutase 1	Homo sapiens	151-154
19321592-0	2009	Poly (ADP-ribose) polymerase-1-inhibiting flavonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes.	Flavonoids	42-52	poly(ADP-ribose) polymerase 1	Homo sapiens	0-30
19321592-1	2009	Recently, we identified several flavonoids as inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 in vitro and in vivo.	Flavonoids	32-42	poly(ADP-ribose) polymerase 1	Homo sapiens	79-115
19321592-3	2009	In this study, we assessed the antiinflammatory effects of flavonoids with varying PARP-1-inhibiting effects in whole blood from male patients with COPD or T2D and healthy men.	Flavonoids	59-69	poly(ADP-ribose) polymerase 1	Homo sapiens	83-89
19627010-0	2009	[Effect of total flavonoids of Hippophae rhamnoides L. on the expression of MCP-1 in aorta of spontaneously hypertensive rats].	Flavonoids	17-27	C-C motif chemokine ligand 2	Rattus norvegicus	76-81
19627010-1	2009	OBJECTIVE: To study the effects of total flavonoids of Hippophae rhamnoides L. (TFH) on the expression of monocyte chemoattractant protein (MCP-1) in aorta of Spontaneously Hypertensive Rats (SHR) and to study the relationship of expression of MCP-1 in aorta and intimal medial thickness (IMT) of aorta.	Flavonoids	41-51	C-C motif chemokine ligand 2	Rattus norvegicus	140-145
19651800-3	2009	For example, butylated hydroxytoluene can prevent production of O2*- in mitochondria, whereas flavonoids can induce expression of antioxidant enzymes, SOD and catalase.	Flavonoids	94-104	catalase	Homo sapiens	159-167
19771849-2	2009	METHODS: The induction of EGb, flavonoids and terpenoids on a typical antioxidant enzyme, glutamate cysteine ligase catalytic subunit (GCLC), in cell lines was detected by Western-blot.	Flavonoids	31-41	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	90-133
19771849-2	2009	METHODS: The induction of EGb, flavonoids and terpenoids on a typical antioxidant enzyme, glutamate cysteine ligase catalytic subunit (GCLC), in cell lines was detected by Western-blot.	Flavonoids	31-41	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	135-139
19771849-4	2009	RESULTS: EGb and flavonoids but not terpenoids were demonstrated significantly to induce the antioxidant enzyme (GCLC), directly scavenge O2*(-), OH* and inhibit rat erythrocyte hemolysis and lipid peroxidation of rat liver homogenate.	Flavonoids	17-27	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	113-117
19286049-2	2009	In this study, we investigated the genetic-, time-, dose-, species- and tissue-dependent AhR-mediated agonistic/antagonistic activities of three food flavonoids: quercetin, chrysin and genistein.	Flavonoids	150-160	aryl hydrocarbon receptor	Homo sapiens	89-92
19426678-9	2009	These results demonstrate that TBK1 is a novel target of anti-inflammatory flavonoids resulting in the down-regulation of the TRIF-dependent signaling pathway.	Flavonoids	75-85	TANK binding kinase 1	Homo sapiens	31-35
19426678-9	2009	These results demonstrate that TBK1 is a novel target of anti-inflammatory flavonoids resulting in the down-regulation of the TRIF-dependent signaling pathway.	Flavonoids	75-85	TIR domain containing adaptor molecule 1	Homo sapiens	126-130
19297174-6	2009	On the basis of the reported weak activity of some flavonoids on phosphatases, we discovered a lead that originated a new class of highly active LMW-PTP inhibitors; these compounds inhibit also PTP-1B and are active in cellular assays.	Flavonoids	51-61	acid phosphatase 1	Homo sapiens	145-152
19467635-4	2009	Naringenin also inhibited LPS/IFN-gamma-induced iNOS expression and nitric oxide production in glial cells, thus showing the strongest anti-inflammatory activity among all flavonoids tested.	Flavonoids	172-182	interferon regulatory factor 6	Homo sapiens	26-29
19467635-4	2009	Naringenin also inhibited LPS/IFN-gamma-induced iNOS expression and nitric oxide production in glial cells, thus showing the strongest anti-inflammatory activity among all flavonoids tested.	Flavonoids	172-182	interferon gamma	Homo sapiens	30-39
19297174-6	2009	On the basis of the reported weak activity of some flavonoids on phosphatases, we discovered a lead that originated a new class of highly active LMW-PTP inhibitors; these compounds inhibit also PTP-1B and are active in cellular assays.	Flavonoids	51-61	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	194-200
19336903-11	2009	In conclusion, the basal structure and the substituents of flavonoids are important in the inhibitory effects of flavonoids on CYP3A activity.	Flavonoids	59-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-132
19336903-11	2009	In conclusion, the basal structure and the substituents of flavonoids are important in the inhibitory effects of flavonoids on CYP3A activity.	Flavonoids	113-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-132
19288491-0	2009	Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships.	Flavonoids	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	44-58
19288491-7	2009	Comparisons of flavonoid heterodimers with the corresponding homodimers revealed that the two binding sites on P-gp for flavonoid moieties are quite similar to each other.	Flavonoids	15-24	phosphoglycolate phosphatase	Homo sapiens	111-115
19288491-7	2009	Comparisons of flavonoid heterodimers with the corresponding homodimers revealed that the two binding sites on P-gp for flavonoid moieties are quite similar to each other.	Flavonoids	120-129	phosphoglycolate phosphatase	Homo sapiens	111-115
19336903-4	2009	In this study, we investigated the inhibitory potentials on cytochrome P450 (CYP) 3A activity of 23 flavonoids using human liver microsomes, and tried to identify the molecular features that cause the inhibition of CYP3A.	Flavonoids	100-110	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	215-220
19336903-6	2009	We analyzed Quantification Theory I, in which extreme values of the inhibitory effects of CYP3A activity were tested with flavonoids supplied at a level of 10 microM.	Flavonoids	122-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-95
19017686-4	2009	Nevertheless, other nutrients such as glutamine, spicy food or flavonoids are also able to activate PPAR gamma.	Flavonoids	63-73	peroxisome proliferator activated receptor gamma	Homo sapiens	100-110
18830885-0	2009	Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors.	Flavonoids	45-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-103
18830885-1	2009	A new series of flavonoid derivatives have been designed, synthesised and evaluated as acetylcholinesterase inhibitors that could bind simultaneously to the peripheral and catalytic sites of the enzyme.	Flavonoids	16-25	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
19050992-8	2009	Treatment with flavonoids or diazepam for 6 days upregulated PBR mRNA expression and cell cytotoxicity of SNU-C4 cells.	Flavonoids	15-25	translocator protein	Homo sapiens	61-64
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	Flavonoids	208-218	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-88
19034627-0	2009	Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.	Flavonoids	25-35	nuclear receptor subfamily 1 group I member 2	Homo sapiens	130-149
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	Flavonoids	208-218	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
19034627-0	2009	Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.	Flavonoids	25-35	nuclear receptor subfamily 1 group I member 3	Homo sapiens	151-183
19034627-0	2009	Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.	Flavonoids	25-35	aryl hydrocarbon receptor	Homo sapiens	189-214
19034627-6	2009	Notably, the flavonoids induced the expression of UGT1A1 and CYP1A2 in HepG2 cells but not in HPH.	Flavonoids	13-23	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	50-56
19034627-6	2009	Notably, the flavonoids induced the expression of UGT1A1 and CYP1A2 in HepG2 cells but not in HPH.	Flavonoids	13-23	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	61-67
19034627-7	2009	CONCLUSION: Our results indicate that terpenoids and flavonoids of GBE exhibit differential induction of DMEs through the selective activation of PXR, CAR, and AhR.	Flavonoids	53-63	nuclear receptor subfamily 1 group I member 2	Homo sapiens	146-149
19034627-1	2009	PURPOSE: The objective of the current study is to investigate the hypothesis that bioactive terpenoids and flavonoids of Ginkgo biloba extract (GBE) induce human hepatic drug metabolizing enzymes (DMEs) and transporters through the selective activation of pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR).	Flavonoids	107-117	nuclear receptor subfamily 1 group I member 2	Homo sapiens	256-275
19222219-0	2009	Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide.	Flavonoids	65-74	mitogen-activated protein kinase 8	Rattus norvegicus	19-22
19034627-1	2009	PURPOSE: The objective of the current study is to investigate the hypothesis that bioactive terpenoids and flavonoids of Ginkgo biloba extract (GBE) induce human hepatic drug metabolizing enzymes (DMEs) and transporters through the selective activation of pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR).	Flavonoids	107-117	nuclear receptor subfamily 1 group I member 2	Homo sapiens	277-280
19034627-1	2009	PURPOSE: The objective of the current study is to investigate the hypothesis that bioactive terpenoids and flavonoids of Ginkgo biloba extract (GBE) induce human hepatic drug metabolizing enzymes (DMEs) and transporters through the selective activation of pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR).	Flavonoids	107-117	nuclear receptor subfamily 1 group I member 3	Homo sapiens	283-315
19034627-1	2009	PURPOSE: The objective of the current study is to investigate the hypothesis that bioactive terpenoids and flavonoids of Ginkgo biloba extract (GBE) induce human hepatic drug metabolizing enzymes (DMEs) and transporters through the selective activation of pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR).	Flavonoids	107-117	nuclear receptor subfamily 1 group I member 3	Homo sapiens	317-320
19034627-1	2009	PURPOSE: The objective of the current study is to investigate the hypothesis that bioactive terpenoids and flavonoids of Ginkgo biloba extract (GBE) induce human hepatic drug metabolizing enzymes (DMEs) and transporters through the selective activation of pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR).	Flavonoids	107-117	aryl hydrocarbon receptor	Homo sapiens	327-352
19034627-1	2009	PURPOSE: The objective of the current study is to investigate the hypothesis that bioactive terpenoids and flavonoids of Ginkgo biloba extract (GBE) induce human hepatic drug metabolizing enzymes (DMEs) and transporters through the selective activation of pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR).	Flavonoids	107-117	aryl hydrocarbon receptor	Homo sapiens	354-357
18835421-0	2009	Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.	Flavonoids	0-10	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	58-100
19034627-7	2009	CONCLUSION: Our results indicate that terpenoids and flavonoids of GBE exhibit differential induction of DMEs through the selective activation of PXR, CAR, and AhR.	Flavonoids	53-63	nuclear receptor subfamily 1 group I member 3	Homo sapiens	151-154
19034627-7	2009	CONCLUSION: Our results indicate that terpenoids and flavonoids of GBE exhibit differential induction of DMEs through the selective activation of PXR, CAR, and AhR.	Flavonoids	53-63	aryl hydrocarbon receptor	Homo sapiens	160-163
19350454-3	2009	hSULT1A1 and hSULT1A3 as well as human intestine cytosol can catalyse the sulfation of the investigated flavonoids.	Flavonoids	104-114	sulfotransferase family 1A member 1	Homo sapiens	0-8
19350454-3	2009	hSULT1A1 and hSULT1A3 as well as human intestine cytosol can catalyse the sulfation of the investigated flavonoids.	Flavonoids	104-114	sulfotransferase family 1A member 3	Homo sapiens	13-21
19222219-0	2009	Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide.	Flavonoids	65-74	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
19222219-0	2009	Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide.	Flavonoids	65-74	mitogen activated protein kinase 14	Rattus norvegicus	28-31
19222219-5	2009	Pretreatment with flavonoids (0.8 or 50 microM) increased cell viability and catalase activity (CA) and decreased membrane damage, reactive oxygen species (ROS) generation, intracellular calcium level ([Ca2+]i), and caspase-3 activity in H2O2-treated PC12 cells.	Flavonoids	18-28	caspase 3	Rattus norvegicus	216-225
19074160-8	2009	Quantitative analyses of all tested wines and of samples collected at various time points (Days 0-16) of the "mash fermentation", which is only performed for red wine, revealed that flavonoids of the catechin family, which potently inhibit PDGFR signalling, are extracted from grape seeds and skins during this process and therefore accumulate specifically in red wine.	Flavonoids	182-192	platelet derived growth factor receptor beta	Homo sapiens	240-245
19222219-7	2009	Based on their structural differences and the concentrations used, these flavonoids differentially activated pro-survival signaling molecules, including Akt/protein kinase B, p38 mitogen-activated protein kinase, and inhibited the activation of c-jun N-terminal kinase, which triggers apoptosis.	Flavonoids	73-83	AKT serine/threonine kinase 1	Rattus norvegicus	153-156
19222219-7	2009	Based on their structural differences and the concentrations used, these flavonoids differentially activated pro-survival signaling molecules, including Akt/protein kinase B, p38 mitogen-activated protein kinase, and inhibited the activation of c-jun N-terminal kinase, which triggers apoptosis.	Flavonoids	73-83	mitogen activated protein kinase 14	Rattus norvegicus	175-178
19007764-7	2009	In this study, some dietary flavonoids and other phenolic compounds were tested for their ability to specifically inhibit AKR1C3.	Flavonoids	28-38	aldo-keto reductase family 1 member C3	Homo sapiens	122-128
19007764-0	2009	AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids.	Flavonoids	66-76	aldo-keto reductase family 1 member C3	Homo sapiens	0-6
19226653-2	2009	Epigallocatechin gallate (EGCG), a flavonoid, was reported to be an inhibitor of both P-gp and CYP3A.	Flavonoids	35-44	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	86-90
19226653-2	2009	Epigallocatechin gallate (EGCG), a flavonoid, was reported to be an inhibitor of both P-gp and CYP3A.	Flavonoids	35-44	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	95-100
19074160-9	2009	The accumulation of flavonoids correlated with the inhibitory potency of red wines on PDGFR signalling.	Flavonoids	20-30	platelet derived growth factor receptor beta	Homo sapiens	86-91
19074160-10	2009	Furthermore, this procedure could be imitated by incubation of wines with shredded grape seeds, and flavonoid-enriched white wine inhibited the PDGFR as potently as red wines.	Flavonoids	100-109	platelet derived growth factor receptor beta	Homo sapiens	144-149
19065667-10	2009	Subsequently, the flavonoid"s effect on CYP19 transcriptional control in vitro was also investigated.	Flavonoids	18-27	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	40-45
19074529-1	2009	This article describes an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) and flavonols (galangin, fisetin, kaempferol, morin, and quercetin).	Flavonoids	112-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-96
19074529-2	2009	With the exception of flavone, all flavonoids were shown to inhibit CYP2C9-mediated diclofenac 4"-hydroxylation in the CYP2C9 RECO system, with K(i) value &lt;or= 2.2 microM.	Flavonoids	35-45	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	68-74
19074529-2	2009	With the exception of flavone, all flavonoids were shown to inhibit CYP2C9-mediated diclofenac 4"-hydroxylation in the CYP2C9 RECO system, with K(i) value &lt;or= 2.2 microM.	Flavonoids	35-45	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	119-125
19074529-5	2009	The other flavonoids exert competitive inhibition through interaction with the substrate binding site of CYP2C9 accessed by flurbiprofen.	Flavonoids	10-20	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	105-111
19074529-6	2009	These results suggest flavonoids can participate in interactions with drugs that act as substrates for CYP2C9 and provide a possible molecular basis for understanding cooperativity in human P450-mediated drug-drug interactions.	Flavonoids	22-32	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-109
18410522-0	2009	Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer"s disease beta-amyloid production.	Flavonoids	0-9	presenilin 1	Mus musculus	19-31
19212680-0	2009	Retinoids induce differentiation and downregulate telomerase activity and N-Myc to increase sensitivity to flavonoids for apoptosis in human malignant neuroblastoma SH-SY5Y cells.	Flavonoids	107-117	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
19548445-3	2009	The authors found that epimedium flavonoids (EF) can promote the proliferation and migration of adrenocortical stem cells in corticosterone-treated rats (as a model of Shen-yang deficiency); and through gene-chip test it was showed that EF could significantly up-regulate the growth hormone (GH), growth hormone releasing hormone (GHRH) and other growth factors such as insulin-like growth factor binding protein (IGFBP) and nerve growth factor (NGF) in the model rats.	Flavonoids	33-43	gonadotropin releasing hormone receptor	Rattus norvegicus	276-290
19228327-2	2009	TTG1 (Transparent Testa Glabra 1), a WD-40 repeat protein, is involved in regulation of flavonoid/anthocyanin biosynthesis, seed coat (mucilage) development/pigmentation and trichome formation in leaves.	Flavonoids	88-97	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	0-4
19825611-9	2009	As ntra ntrb plants are more resistant to UV-C treatment than wild-type plants, this higher resistance was abolished in the ntra ntrb tt4 mutant, suggesting that accumulation of flavonoids in the ntra ntrb mutant protects plants against UV-light.	Flavonoids	178-188	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	134-137
19548445-3	2009	The authors found that epimedium flavonoids (EF) can promote the proliferation and migration of adrenocortical stem cells in corticosterone-treated rats (as a model of Shen-yang deficiency); and through gene-chip test it was showed that EF could significantly up-regulate the growth hormone (GH), growth hormone releasing hormone (GHRH) and other growth factors such as insulin-like growth factor binding protein (IGFBP) and nerve growth factor (NGF) in the model rats.	Flavonoids	33-43	gonadotropin releasing hormone receptor	Rattus norvegicus	292-294
19548445-3	2009	The authors found that epimedium flavonoids (EF) can promote the proliferation and migration of adrenocortical stem cells in corticosterone-treated rats (as a model of Shen-yang deficiency); and through gene-chip test it was showed that EF could significantly up-regulate the growth hormone (GH), growth hormone releasing hormone (GHRH) and other growth factors such as insulin-like growth factor binding protein (IGFBP) and nerve growth factor (NGF) in the model rats.	Flavonoids	33-43	growth hormone releasing hormone	Rattus norvegicus	297-329
19548445-3	2009	The authors found that epimedium flavonoids (EF) can promote the proliferation and migration of adrenocortical stem cells in corticosterone-treated rats (as a model of Shen-yang deficiency); and through gene-chip test it was showed that EF could significantly up-regulate the growth hormone (GH), growth hormone releasing hormone (GHRH) and other growth factors such as insulin-like growth factor binding protein (IGFBP) and nerve growth factor (NGF) in the model rats.	Flavonoids	33-43	growth hormone releasing hormone	Rattus norvegicus	331-335
19146827-2	2009	In this paper, we report the identification of kaempferitrin (kaempferol 3,7-dirhamnoside), a glycosylated flavonoid, as a compound that inhibits insulin stimulated GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes.	Flavonoids	107-116	insulin	Homo sapiens	146-153
19103272-9	2009	CONCLUSIONS: PMBE including additional bioactive compounds may possibly synergize to inhibit transcription and translation of inducible ICAM-1expression and PMBE was greater than monomeric flavonoid taxifolin.	Flavonoids	189-198	intercellular adhesion molecule 1	Homo sapiens	136-142
19146827-2	2009	In this paper, we report the identification of kaempferitrin (kaempferol 3,7-dirhamnoside), a glycosylated flavonoid, as a compound that inhibits insulin stimulated GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes.	Flavonoids	107-116	solute carrier family 2 member 4	Homo sapiens	165-170
19037088-0	2009	A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.	Flavonoids	8-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-87
18955122-9	2009	In conclusion, our results show that the new complex prepared by inclusion of dioclein in beta-CD improves the hypotensive effect of the flavonoid by increasing its bioavailability and enables dioclein to be effective after oral administration.	Flavonoids	137-146	beta-carotene oxygenase 1	Mus musculus	90-97
18976853-3	2009	In this study we investigated the anticancer activity of the flavonoid diosmetin, as a result of cytochrome P450 CYP1 metabolism.	Flavonoids	61-70	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	108-112
18976853-3	2009	In this study we investigated the anticancer activity of the flavonoid diosmetin, as a result of cytochrome P450 CYP1 metabolism.	Flavonoids	61-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-117
18976853-9	2009	Taken together these data suggest that the flavonoid diosmetin is metabolised to the more active molecule luteolin by CYP1 family enzymes.	Flavonoids	43-52	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-122
19116149-5	2009	Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.	Flavonoids	94-104	signal transducer and activator of transcription 1	Homo sapiens	84-89
19116149-5	2009	Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.	Flavonoids	94-104	signal transducer and activator of transcription 1	Homo sapiens	115-120
19026990-3	2009	We investigated the inhibitory effects of 3,3",4",5,5",7-hexahydroxyflavone (myricetin), an abundant natural flavonoid, on TNF-alpha-induced VEGF upregulation and the underlying molecular mechanism.	Flavonoids	109-118	tumor necrosis factor	Homo sapiens	123-132
19182941-0	2009	Thromboxane A2 receptor antagonism by flavonoids: structure-activity relationships.	Flavonoids	38-48	thromboxane A2 receptor	Homo sapiens	0-23
18955135-0	2009	A 3D linear solvation energy model to quantify the affinity of flavonoid derivatives toward P-glycoprotein.	Flavonoids	63-72	ATP binding cassette subfamily B member 1	Homo sapiens	92-106
18955135-2	2009	Flavonoids, reported as potent Pgp inhibitors, are able to bind to the cytosolic ATP-binding site and a vicinal hydrophobic pocket.	Flavonoids	0-10	phosphoglycolate phosphatase	Homo sapiens	31-34
18955135-3	2009	In order to explore the interaction forces governing the affinity of flavonoids towards Pgp, the 3D quantitative structure-activity relationship (QSAR) approach was used to analyze a set of flavonoid derivatives.	Flavonoids	69-79	phosphoglycolate phosphatase	Homo sapiens	88-91
18955135-3	2009	In order to explore the interaction forces governing the affinity of flavonoids towards Pgp, the 3D quantitative structure-activity relationship (QSAR) approach was used to analyze a set of flavonoid derivatives.	Flavonoids	69-78	phosphoglycolate phosphatase	Homo sapiens	88-91
18955135-5	2009	The 3D linear solvation energy VolSurf model developed here identifies shape parameters and hydrophobicity as the major physicochemical parameters responsible for the affinity of flavonoid derivatives towards Pgp and hydrogen-bonding capacities as minor modulators of this activity.	Flavonoids	179-188	phosphoglycolate phosphatase	Homo sapiens	209-212
19037088-0	2009	A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.	Flavonoids	8-17	epidermal growth factor receptor	Homo sapiens	96-100
19037088-0	2009	A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.	Flavonoids	8-17	nuclear factor kappa B subunit 1	Homo sapiens	101-110
19135106-5	2009	A special attention is drawn on flavonoids which constitute a structurally-diverse class of compounds, well suited to identify potent ABCG2-specific inhibitors.	Flavonoids	32-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	134-139
18679731-3	2009	As metabolic flux for the operation of the flavonoid pathway is maintained through the activities of PAL and C4H, thus, catechins biosynthesis in tea is critically dependent on the products of these enzymes.	Flavonoids	43-52	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	101-104
19054284-0	2009	The Na+-dependent L-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids.	Flavonoids	131-141	solute carrier family 23 member 2	Rattus norvegicus	46-51
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Flavonoids	50-59	anthocyanidin reductase ((2S)-flavan-3-ol-forming)	Vitis vinifera	79-102
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Flavonoids	50-59	leucoanthocyanidin reductase 1	Vitis vinifera	107-137
19098092-8	2009	Both genes significantly activated enzymes of the flavonoid pathway, including anthocyanidin reductase and leucoanthocyanidin reductase 1, the specific terminal steps in the biosynthesis of epicatechin and catechin, respectively, but not leucoanthocyanidin reductase 2.	Flavonoids	50-59	leucoanthocyanidin reductase 2	Vitis vinifera	238-268
19111841-6	2009	Estrogenic compounds including estrone, several tamoxifen derivatives in addition to phytoestrogens and flavonoids have been shown to reverse BCRP-mediated drug resistance.	Flavonoids	104-114	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	142-146
19020811-3	2009	All the flavonoids inhibited the efflux of MRP1 fluorescent substrate from human erythrocytes and breast cancer cells.	Flavonoids	8-18	ATP binding cassette subfamily C member 1	Homo sapiens	43-47
19041703-10	2009	CONCLUSION: These results indicate that the anti-inflammatory activity of flavonoids from tayuya roots most likely stems from their inhibition of the induction of the enzymes COX-2 and iNOS.	Flavonoids	74-84	cytochrome c oxidase II, mitochondrial	Mus musculus	175-180
19041703-10	2009	CONCLUSION: These results indicate that the anti-inflammatory activity of flavonoids from tayuya roots most likely stems from their inhibition of the induction of the enzymes COX-2 and iNOS.	Flavonoids	74-84	nitric oxide synthase 2, inducible	Mus musculus	185-189
19774231-5	2009	These flavonoids accelerated reduction of ferryl hemoglobin to methemoglobin.	Flavonoids	6-16	hemoglobin subunit gamma 2	Homo sapiens	63-76
19020811-8	2009	We concluded that mechanisms other than perturbation of the lipid phase of membranes were responsible for inhibition of MRP1 by the flavonoids.	Flavonoids	132-142	ATP binding cassette subfamily C member 1	Homo sapiens	120-124
19897959-16	2009	Finally, food components can strengthen the epithelial barrier as for example the flavonoid quercetin which has been shown to upregulate claudin-4 within the epithelial TJ.	Flavonoids	82-91	claudin 4	Homo sapiens	137-146
19662717-0	2009	Influence of flavonoid-rich fraction from Spermacoce hispida seed on PPAR-alpha gene expression, antioxidant redox status, protein metabolism and marker enzymes in high-fat-diet fed STZ diabetic rats.	Flavonoids	13-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	69-79
20027147-0	2009	Modulation of cytochrome P450 enzyme system by selected flavonoids.	Flavonoids	56-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-29
19470292-0	2009	Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy.	Flavonoids	25-35	ATP binding cassette subfamily B member 1	Homo sapiens	39-53
19470292-9	2009	Flavonoids (polyphenolic herbal constituents) form the third generation, non-pharmaceutical category of P-gp inhibitors.	Flavonoids	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	104-108
19470292-13	2009	This paper presents an overview of the investigations on the feasibility and application of flavonoids as P-gp modulators for improved efficacy of anti-cancer drugs like taxanes, anthracyclines, epipodophyllotoxins, camptothecins and vinca alkaloids.	Flavonoids	92-102	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
17590240-2	2009	Evidence is increasing that green tea flavonoids can protect cells from A beta-mediated neurotoxicity.	Flavonoids	38-48	amyloid beta precursor protein	Homo sapiens	72-78
20027147-1	2009	OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activity in respect of the reduction of different electron acceptors as well as to study an impact of flavonoids on monooxygenation of a model substrate of cytochrome P450 (CYP).	Flavonoids	70-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	126-129
20027147-1	2009	OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activity in respect of the reduction of different electron acceptors as well as to study an impact of flavonoids on monooxygenation of a model substrate of cytochrome P450 (CYP).	Flavonoids	235-245	cytochrome p450 oxidoreductase	Homo sapiens	126-131
19704917-5	2009	Additionally, the flavonoid interferes with the angiogenic process by inhibiting VEGF production as well as by altering redox status.	Flavonoids	18-27	vascular endothelial growth factor A	Sus scrofa	81-85
19129169-6	2009	Flavonols were the most drastically reduced flavonoids following shading and leaf removal treatments, related to the reduced expression of FLAVONOL SYNTHASE 4 and its putative transcriptional regulator MYB12.	Flavonoids	44-54	R2R3 MYB 12 transcription factor	Vitis vinifera	202-207
19732493-1	2009	PURPOSE: The activities of breast cancer resistance protein (Bcrp/ABCG2) as well as P-glycoprotein (P-gp) and drug-metabolizing enzymes can be inhibited by several flavonoids or drugs in rats.	Flavonoids	164-174	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	61-65
19732493-1	2009	PURPOSE: The activities of breast cancer resistance protein (Bcrp/ABCG2) as well as P-glycoprotein (P-gp) and drug-metabolizing enzymes can be inhibited by several flavonoids or drugs in rats.	Flavonoids	164-174	ATP binding cassette subfamily G member 2	Rattus norvegicus	66-71
19732493-1	2009	PURPOSE: The activities of breast cancer resistance protein (Bcrp/ABCG2) as well as P-glycoprotein (P-gp) and drug-metabolizing enzymes can be inhibited by several flavonoids or drugs in rats.	Flavonoids	164-174	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	84-98
19732493-1	2009	PURPOSE: The activities of breast cancer resistance protein (Bcrp/ABCG2) as well as P-glycoprotein (P-gp) and drug-metabolizing enzymes can be inhibited by several flavonoids or drugs in rats.	Flavonoids	164-174	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	100-104
19732493-2	2009	However, the species, gender and regional differences of effects of flavonoids on Bcrp/ABCG2 in rats and mice remain unclear, although Bcrp, like P-gp, is also important in controlling drug absorption and disposition.	Flavonoids	68-78	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	82-86
19732493-2	2009	However, the species, gender and regional differences of effects of flavonoids on Bcrp/ABCG2 in rats and mice remain unclear, although Bcrp, like P-gp, is also important in controlling drug absorption and disposition.	Flavonoids	68-78	ATP binding cassette subfamily G member 2	Rattus norvegicus	87-92
20027147-1	2009	OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activity in respect of the reduction of different electron acceptors as well as to study an impact of flavonoids on monooxygenation of a model substrate of cytochrome P450 (CYP).	Flavonoids	235-245	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	94-109
20027147-1	2009	OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activity in respect of the reduction of different electron acceptors as well as to study an impact of flavonoids on monooxygenation of a model substrate of cytochrome P450 (CYP).	Flavonoids	235-245	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	126-129
20027147-1	2009	OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activity in respect of the reduction of different electron acceptors as well as to study an impact of flavonoids on monooxygenation of a model substrate of cytochrome P450 (CYP).	Flavonoids	70-80	cytochrome p450 oxidoreductase	Homo sapiens	88-124
20027147-1	2009	OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activity in respect of the reduction of different electron acceptors as well as to study an impact of flavonoids on monooxygenation of a model substrate of cytochrome P450 (CYP).	Flavonoids	70-80	cytochrome p450 oxidoreductase	Homo sapiens	126-131
20027147-1	2009	OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activity in respect of the reduction of different electron acceptors as well as to study an impact of flavonoids on monooxygenation of a model substrate of cytochrome P450 (CYP).	Flavonoids	70-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	94-109
18998159-1	2009	Flavonol synthase (FLS) (EC-number 1.14.11.23), the enzyme that catalyses the conversion of flavonols into dihydroflavonols, is part of the flavonoid biosynthesis pathway.	Flavonoids	140-149	flavonol synthase 1	Arabidopsis thaliana	0-17
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Flavonoids	77-87	hematopoietic prostaglandin D synthase	Rattus norvegicus	159-184
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Flavonoids	77-87	hematopoietic prostaglandin D synthase	Rattus norvegicus	186-189
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Flavonoids	77-87	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	195-227
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Flavonoids	77-87	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	229-233
19838946-8	2009	Current data indicate that dietary flavonoids have little effects on liver oxidant/antioxidant status but do significantly affect the phase II enzymes GST and NQO1 in rat liver.	Flavonoids	35-45	hematopoietic prostaglandin D synthase	Rattus norvegicus	151-154
19838946-8	2009	Current data indicate that dietary flavonoids have little effects on liver oxidant/antioxidant status but do significantly affect the phase II enzymes GST and NQO1 in rat liver.	Flavonoids	35-45	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	159-163
18998159-5	2009	Although several of the FLS gene family members are expressed, only FLS1 appeared to influence flavonoid biosynthesis.	Flavonoids	95-104	flavonol synthase 1	Arabidopsis thaliana	68-72
18998159-1	2009	Flavonol synthase (FLS) (EC-number 1.14.11.23), the enzyme that catalyses the conversion of flavonols into dihydroflavonols, is part of the flavonoid biosynthesis pathway.	Flavonoids	140-149	flavonol synthase 1	Arabidopsis thaliana	19-22
19323275-10	2009	In summary, the present study describes the dual modulation of P-gp expression and function by the flavonoid naringin, which may be an attractive new agent for the chemosensitization of cancer cells.	Flavonoids	99-108	ATP binding cassette subfamily B member 1	Homo sapiens	63-67
18715823-1	2009	The interaction of quercetin, which is a bioflavonoid, with bovine serum albumin (BSA) was investigated under pseudo-physiological conditions by the application of UV-vis spectrometry, spectrofluorimetry and cyclic voltammetry (CV).	Flavonoids	41-53	albumin	Homo sapiens	67-80
19197122-0	2009	Structure-activity relationship of 7 flavonoids on recombinant human protein kinase CK2 holoenzyme.	Flavonoids	37-47	casein kinase 2 alpha 1	Homo sapiens	69-87
19197122-1	2009	OBJECTIVE: To observe the effect of 7 flavonoids on recombinant human protein kinase CK 2 holoenzyme activity and investigate their structure-activity relationship.	Flavonoids	38-48	casein kinase 2 alpha 1	Homo sapiens	70-89
19035656-6	2008	Liver GST activity, however, was approximately 25% higher than controls for the freeze-dried whole blueberry, blueberry polyphenol, and 1% flavonoid groups.	Flavonoids	139-148	hematopoietic prostaglandin D synthase	Rattus norvegicus	6-9
19197122-9	2009	CONCLUSION: The inhibitory effect of flavonoid on protein kinase CK 2 in vitro may be determined by the position of their hydroxyl groups.	Flavonoids	37-46	casein kinase 2 alpha 1	Homo sapiens	50-69
18723037-8	2008	Therefore, the present study revealed an underlying mechanism for the selective anxiolytic profile of baicalin, suggesting alpha2- and alpha3-containing subtypes were important drug targets for flavonoid-based anxiolytics.	Flavonoids	194-203	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	123-141
18848530-5	2008	Here, we first found that Licochalcone A, one of the flavonoids isolated from the root of Glycyrrhiza inflate, inhibited TEL-Jak2-mediated cell proliferation and survival in the absence of IL-3.	Flavonoids	53-63	ETS variant transcription factor 6	Homo sapiens	121-124
18673301-10	2008	We have confirmed the feasibility of using this assay to detect the interaction of ligands with RAR-beta by investigating the ability of certain flavonoids to inhibit the binding of [(3)H]CD367 to nuclear extracts from HRPE cells.	Flavonoids	145-155	retinoic acid receptor beta	Homo sapiens	96-104
18673301-11	2008	The inhibition constant of the flavonoids for RAR-beta was between approx.	Flavonoids	31-41	retinoic acid receptor beta	Homo sapiens	46-54
18673301-12	2008	1-30 microM, showing that the flavonoids interact with RAR-beta with low affinity.	Flavonoids	30-40	retinoic acid receptor beta	Homo sapiens	55-63
19244749-0	2008	[Inhibition of human cytochrome P-450 CYP1A2 by flavonoids: a quantitative structure-activity relationship study ].	Flavonoids	48-58	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-44
17869316-2	2008	We investigated AhR activation by some vegetable constituents, including flavonoids, tannins, and related polyphenols, using an AhR-based in vitro bioassay for dioxins.	Flavonoids	73-83	aryl hydrocarbon receptor	Homo sapiens	16-19
18951251-0	2008	Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models.	Flavonoids	19-29	ATP binding cassette subfamily B member 1	Homo sapiens	65-79
18951251-13	2008	These results suggest that flavonoids may have potential to alter the disposition profile of cimetidine and possibly other therapeutics that are mediated by P-gp and/or cation transport systems.	Flavonoids	27-37	ATP binding cassette subfamily B member 1	Homo sapiens	157-161
18803250-2	2008	Three citrus flavonoids - naringin, naringenin and hesperidin - have been examined for their ability to activate caspase-3, a marker of apoptosis execution, in human polymorphonuclear neutrophils in vitro, stimulated and non-stimulated with phorbol 12-myristate 13-acetate.	Flavonoids	13-23	caspase 3	Homo sapiens	113-122
18803250-4	2008	The caspase-3 activity depended on the time of flavonoid treatment and was increased markedly in phorbol-treated cells incubated with flavonoids for 24 h. Hesperidin at a concentration of 100 microm exerted the strongest stimulating effect on the enzyme (137% of control).	Flavonoids	47-56	caspase 3	Homo sapiens	4-13
18803250-4	2008	The caspase-3 activity depended on the time of flavonoid treatment and was increased markedly in phorbol-treated cells incubated with flavonoids for 24 h. Hesperidin at a concentration of 100 microm exerted the strongest stimulating effect on the enzyme (137% of control).	Flavonoids	134-144	caspase 3	Homo sapiens	4-13
19244749-1	2008	The inhibition activity of 36 flavonoids against CYP1A2 was determined by our previously developed in vitro method.	Flavonoids	30-40	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	49-55
18974136-3	2008	We show for the first time that a naturally occurring flavonoid, baicalein, overcomes TRAIL resistance in cancer cells.	Flavonoids	54-63	TNF superfamily member 10	Homo sapiens	86-91
18718912-0	2008	Flavonoids redirect PIN-mediated polar auxin fluxes during root gravitropic responses.	Flavonoids	0-10	dynein light chain LC8-type 1	Homo sapiens	20-23
18718912-7	2008	Chemical complementation by flavonoids correlates with an asymmetric distribution of the PIN1 protein.	Flavonoids	28-38	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	89-93
18718912-9	2008	We propose that flavonoids promote asymmetric PIN shifts during gravity stimulation, thus redirecting basipetal auxin streams necessary for root bending.	Flavonoids	16-26	dynein light chain LC8-type 1	Homo sapiens	46-49
18952844-6	2008	Interestingly, inhibition of Thr-55 phosphorylation by a dietary flavonoid, apigenin, specifically blocks the CRM1-p53 association, restores p53 nuclear localization, and sensitizes tumor cells with cytoplasm localized wild-type p53 to DNA damage.	Flavonoids	65-74	exportin 1	Homo sapiens	110-114
18952844-6	2008	Interestingly, inhibition of Thr-55 phosphorylation by a dietary flavonoid, apigenin, specifically blocks the CRM1-p53 association, restores p53 nuclear localization, and sensitizes tumor cells with cytoplasm localized wild-type p53 to DNA damage.	Flavonoids	65-74	tumor protein p53	Homo sapiens	115-118
18952844-6	2008	Interestingly, inhibition of Thr-55 phosphorylation by a dietary flavonoid, apigenin, specifically blocks the CRM1-p53 association, restores p53 nuclear localization, and sensitizes tumor cells with cytoplasm localized wild-type p53 to DNA damage.	Flavonoids	65-74	tumor protein p53	Homo sapiens	141-144
18952844-6	2008	Interestingly, inhibition of Thr-55 phosphorylation by a dietary flavonoid, apigenin, specifically blocks the CRM1-p53 association, restores p53 nuclear localization, and sensitizes tumor cells with cytoplasm localized wild-type p53 to DNA damage.	Flavonoids	65-74	tumor protein p53	Homo sapiens	141-144
18725386-0	2008	Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.	Flavonoids	6-15	AKT serine/threonine kinase 1	Homo sapiens	37-40
19012573-0	2008	Comparative QSAR studies of CYP1A2 inhibitor flavonoids using 2D and 3D descriptors.	Flavonoids	45-55	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	28-34
19012573-1	2008	Comparative Quantitative Structure Activity Relationship (QSAR) analyses have been performed with 21 naturally occurring flavonoids for their inhibitory effects on cytochrome P450 1A2 enzyme using two-dimensional (topological, structural, and thermodynamic) and three-dimensional (spatial) descriptors.	Flavonoids	121-131	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	164-183
18953257-8	2008	CONCLUSIONS: Our results demonstrate that the flavonoid apigenin decreases glucose uptake and downregulates the GLUT-1 glucose transporter in human pancreatic cancer cells.	Flavonoids	46-55	solute carrier family 2 member 1	Homo sapiens	112-118
19001439-0	2008	The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin.	Flavonoids	4-13	TNF superfamily member 10	Homo sapiens	58-63
19001439-2	2008	Here, we report that kaempferol, a bioactive plant flavonoid, sensitizes U251 and U87 glioma cells to TRAIL-mediated apoptosis.	Flavonoids	51-60	TNF superfamily member 10	Homo sapiens	102-107
18404646-12	2008	In conclusion, our studies demonstrated that geminin is overexpressed in human pancreatic cancer and downregulated by apigenin which may contribute to the antitumor effect of this natural flavonoid.	Flavonoids	188-197	geminin DNA replication inhibitor	Homo sapiens	45-52
18625698-3	2008	In particular, a gene for one of the key enzymes for flavonoid biosynthesis, chalcone synthase (CHS), was strongly inhibited.	Flavonoids	53-62	chalcone synthase	Raphanus sativus	77-94
18775438-0	2008	Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein.	Flavonoids	74-83	synuclein alpha	Homo sapiens	30-45
18775438-1	2008	The flavonoid baicalein inhibits fibrillation of alpha-synuclein, which is a major component of Lewy bodies in Parkinson"s disease.	Flavonoids	4-13	synuclein alpha	Homo sapiens	49-64
18922931-0	2008	A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.	Flavonoids	16-25	androgen receptor	Homo sapiens	43-60
18922931-4	2008	Here, we report that fisetin, a novel dietary flavonoid, acts as a novel AR ligand by competing with the high-affinity androgen to interact with the ligand binding domain of AR.	Flavonoids	46-55	androgen receptor	Homo sapiens	73-75
18922931-4	2008	Here, we report that fisetin, a novel dietary flavonoid, acts as a novel AR ligand by competing with the high-affinity androgen to interact with the ligand binding domain of AR.	Flavonoids	46-55	androgen receptor	Homo sapiens	174-176
18842789-0	2008	Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men.	Flavonoids	13-23	endothelin 1	Homo sapiens	95-107
18842789-2	2008	OBJECTIVE: The objective was to assess whether pure dietary flavonoids can modulate nitric oxide and endothelin-1 production and thereby improve endothelial function.	Flavonoids	60-70	endothelin 1	Homo sapiens	101-113
18842789-11	2008	CONCLUSIONS: Dietary flavonoids, such as quercetin and (-)-epicatechin, can augment nitric oxide status and reduce endothelin-1 concentrations and may thereby improve endothelial function.	Flavonoids	21-31	endothelin 1	Homo sapiens	115-127
18625698-3	2008	In particular, a gene for one of the key enzymes for flavonoid biosynthesis, chalcone synthase (CHS), was strongly inhibited.	Flavonoids	53-62	chalcone synthase	Raphanus sativus	96-99
18625698-5	2008	In this study, the expression patterns of the early genes in the flavonoid biosynthesis pathway, including CHS, were investigated in normal and male-sterile lines.	Flavonoids	65-74	chalcone synthase	Raphanus sativus	107-110
18625698-8	2008	KEY RESULTS: Among the flavonoid biosynthetic genes analysed, the expression of CHS was strongly inhibited in the later stages of anther development in sterility cytoplasm; accumulation of putative naringenin derivatives was also inhibited.	Flavonoids	23-32	chalcone synthase	Raphanus sativus	80-83
18813848-6	2008	EVOO polyphenols lignans, flavonoids and secoiridoids were found to drastically suppress FASN protein expression in HER2 gene-amplified SKBR3 breast cancer cells.	Flavonoids	26-36	fatty acid synthase	Homo sapiens	89-93
33467792-0	2008	Bioactivity of Flavonoids on Insulin-Secreting Cells.	Flavonoids	15-25	insulin	Homo sapiens	29-36
33467792-11	2008	Published data suggest that there might be direct effects of flavonoids on insulin secretion, as well as on prevention of beta-cell apoptosis, and they could even act via modulation of proliferation.	Flavonoids	61-71	insulin	Homo sapiens	75-82
18813848-6	2008	EVOO polyphenols lignans, flavonoids and secoiridoids were found to drastically suppress FASN protein expression in HER2 gene-amplified SKBR3 breast cancer cells.	Flavonoids	26-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	116-120
18657430-3	2008	F3H genes are increasingly being used, often together with genes encoding other enzymes, to engineer flavonoid synthesis in microbes and plants.	Flavonoids	101-110	flavanone 3-hydroxylase	Arabidopsis thaliana	0-3
18655183-1	2008	Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia.	Flavonoids	40-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-173
18655183-1	2008	Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia.	Flavonoids	40-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	175-185
18587069-2	2008	Recently, we demonstrated that the flavonoid naringenin, like insulin, decreased apoB secretion from HepG2 cells by activation of both the phosphoinositide-3-kinase (PI3-K) pathway and the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK(erk)) pathway.	Flavonoids	35-44	apolipoprotein B	Homo sapiens	81-85
18587069-2	2008	Recently, we demonstrated that the flavonoid naringenin, like insulin, decreased apoB secretion from HepG2 cells by activation of both the phosphoinositide-3-kinase (PI3-K) pathway and the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK(erk)) pathway.	Flavonoids	35-44	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	139-164
18587069-2	2008	Recently, we demonstrated that the flavonoid naringenin, like insulin, decreased apoB secretion from HepG2 cells by activation of both the phosphoinositide-3-kinase (PI3-K) pathway and the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK(erk)) pathway.	Flavonoids	35-44	mitogen-activated protein kinase 1	Homo sapiens	259-262
18690615-0	2008	Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.	Flavonoids	31-41	adiponectin, C1Q and collagen domain containing	Mus musculus	101-112
18690615-6	2008	These results suggested the two flavonoids might exert antiatherogenic effects partly through activating PPAR and up-regulating adiponectin expression in adipocytes.	Flavonoids	32-42	adiponectin, C1Q and collagen domain containing	Mus musculus	128-139
18812033-2	2008	In a previous study we found that total flavonoids of Bidens bipinnata L. (TFB) had a protective effect against carbon tetrachloride (CCl4)-induced acute liver injury in mice.	Flavonoids	40-50	chemokine (C-C motif) ligand 4	Mus musculus	134-138
18720348-8	2008	This novel signaling pathway of procyanidins through SHP may be relevant to explain the health effects ascribed to the regular consumption of dietary flavonoids.	Flavonoids	150-160	nuclear receptor subfamily 0 group B member 2	Homo sapiens	53-56
18715546-3	2008	Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 (tissue inhibitor of metalloproteinase-1) protein level was enhanced by these flavonoid glycosides.	Flavonoids	154-163	matrix metallopeptidase 9	Homo sapiens	34-39
18715546-3	2008	Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 (tissue inhibitor of metalloproteinase-1) protein level was enhanced by these flavonoid glycosides.	Flavonoids	154-163	matrix metallopeptidase 2	Homo sapiens	44-49
18715546-3	2008	Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 (tissue inhibitor of metalloproteinase-1) protein level was enhanced by these flavonoid glycosides.	Flavonoids	154-163	TIMP metallopeptidase inhibitor 1	Homo sapiens	69-75
18715546-3	2008	Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 (tissue inhibitor of metalloproteinase-1) protein level was enhanced by these flavonoid glycosides.	Flavonoids	154-163	TIMP metallopeptidase inhibitor 1	Homo sapiens	77-116
18242769-0	2008	Differential expression of four Arabidopsis PAL genes; PAL1 and PAL2 have functional specialization in abiotic environmental-triggered flavonoid synthesis.	Flavonoids	135-144	PHE ammonia lyase 1	Arabidopsis thaliana	55-59
18729255-6	2008	However, these flavonoids effectively inhibited tyrosinase-catalysed oxidation of l-dihydroxyphenylalanine in cell-free extracts and in living cells.	Flavonoids	15-25	tyrosinase	Mus musculus	48-58
18242769-0	2008	Differential expression of four Arabidopsis PAL genes; PAL1 and PAL2 have functional specialization in abiotic environmental-triggered flavonoid synthesis.	Flavonoids	135-144	phenylalanine ammonia-lyase 2	Arabidopsis thaliana	64-68
18242769-7	2008	PAL1, PAL2 and PAL4 have previously been shown to be related with tissue-specific lignin synthesis, and the present work shows that PAL1 and PAL2 also have functional specialization in abiotic environmental-triggered flavonoid synthesis.	Flavonoids	217-226	PHE ammonia lyase 1	Arabidopsis thaliana	0-4
18242769-7	2008	PAL1, PAL2 and PAL4 have previously been shown to be related with tissue-specific lignin synthesis, and the present work shows that PAL1 and PAL2 also have functional specialization in abiotic environmental-triggered flavonoid synthesis.	Flavonoids	217-226	phenylalanine ammonia-lyase 2	Arabidopsis thaliana	6-10
18242769-7	2008	PAL1, PAL2 and PAL4 have previously been shown to be related with tissue-specific lignin synthesis, and the present work shows that PAL1 and PAL2 also have functional specialization in abiotic environmental-triggered flavonoid synthesis.	Flavonoids	217-226	phenylalanine ammonia-lyase 4	Arabidopsis thaliana	15-19
18242769-7	2008	PAL1, PAL2 and PAL4 have previously been shown to be related with tissue-specific lignin synthesis, and the present work shows that PAL1 and PAL2 also have functional specialization in abiotic environmental-triggered flavonoid synthesis.	Flavonoids	217-226	PHE ammonia lyase 1	Arabidopsis thaliana	132-136
18242769-7	2008	PAL1, PAL2 and PAL4 have previously been shown to be related with tissue-specific lignin synthesis, and the present work shows that PAL1 and PAL2 also have functional specialization in abiotic environmental-triggered flavonoid synthesis.	Flavonoids	217-226	phenylalanine ammonia-lyase 2	Arabidopsis thaliana	141-145
18817573-6	2008	In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators.	Flavonoids	15-25	CD40 molecule	Homo sapiens	81-85
18772380-2	2008	Microarray analysis showed that TT2 induces genes for flavonoid/PA biosynthesis, transcription factors, and a large number of genes of unknown function.	Flavonoids	54-63	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	32-35
18552875-0	2008	Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids.	Flavonoids	87-97	fatty-acid amide hydrolase-like	Rattus norvegicus	14-40
18552875-5	2008	Among the commonly occurring flavonoids, kaempferol was the most potent, inhibiting FAAH in a competitive manner with a K(i) value of 5 microM.	Flavonoids	29-39	fatty-acid amide hydrolase-like	Rattus norvegicus	84-88
18552875-6	2008	Among flavonoids with a more restricted distribution in nature, the two most active toward FAAH were 7-hydroxyflavone (IC(50) value of 0.5-1 microM depending on the solvent used) and 3,7-dihydroxyflavone (IC(50) value 2.2 microM).	Flavonoids	6-16	fatty-acid amide hydrolase-like	Rattus norvegicus	91-95
18552875-8	2008	CONCLUSIONS AND IMPLICATIONS: Inhibition of FAAH is an additional in vitro biochemical property of flavonoids.	Flavonoids	99-109	fatty-acid amide hydrolase-like	Rattus norvegicus	44-48
18790751-2	2008	The hop flavonoid xanthohumol inhibits tumor growth by targeting the nuclear factor-kappaB and Akt pathways and angiogenesis.	Flavonoids	8-17	AKT serine/threonine kinase 1	Homo sapiens	95-98
18406589-0	2008	Effect of total flavonoid fraction of Astragalus complanatus R. Brown on angiotensin II-induced portal-vein contraction in hypertensive rats.	Flavonoids	16-25	angiotensinogen	Rattus norvegicus	73-87
18703589-7	2008	Microarray analysis showed that AtPAO4 deficiency induced alterations in the expression of genes related to the drought stress response and flavonoid biosynthesis.	Flavonoids	140-149	polyamine oxidase 4	Arabidopsis thaliana	32-38
19325836-0	2008	QSAR study of p56(lck) protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS.	Flavonoids	70-79	cyclin dependent kinase like 2	Homo sapiens	14-17
19325836-0	2008	QSAR study of p56(lck) protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS.	Flavonoids	70-79	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
19325836-1	2008	Quantitative relationships between molecular structure and p56(lck) protein tyrosine kinase inhibitory activity of 50 flavonoid derivatives are discovered by MLR and GA-PLS methods.	Flavonoids	118-127	cyclin dependent kinase like 2	Homo sapiens	59-62
19325836-1	2008	Quantitative relationships between molecular structure and p56(lck) protein tyrosine kinase inhibitory activity of 50 flavonoid derivatives are discovered by MLR and GA-PLS methods.	Flavonoids	118-127	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
19325836-5	2008	The models proposed in the present work are more useful in describing QSAR of flavonoid derivatives as p56(lck) protein tyrosine kinase inhibitors than those provided previously.	Flavonoids	78-87	cyclin dependent kinase like 2	Homo sapiens	103-106
19325836-5	2008	The models proposed in the present work are more useful in describing QSAR of flavonoid derivatives as p56(lck) protein tyrosine kinase inhibitors than those provided previously.	Flavonoids	78-87	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
18782055-3	2008	Furthermore, flavonoids stimulate glucose uptake in peripheral tissues, regulate the activity and/or expression of the rate-limiting enzymes in the carbohydrate metabolism pathway and act per se as insulin secretagogues or insulin mimetics, probably, by influencing the pleiotropic mechanisms of insulin signaling, to ameliorate the diabetes status.	Flavonoids	13-23	insulin	Homo sapiens	198-205
18782055-3	2008	Furthermore, flavonoids stimulate glucose uptake in peripheral tissues, regulate the activity and/or expression of the rate-limiting enzymes in the carbohydrate metabolism pathway and act per se as insulin secretagogues or insulin mimetics, probably, by influencing the pleiotropic mechanisms of insulin signaling, to ameliorate the diabetes status.	Flavonoids	13-23	insulin	Homo sapiens	223-230
18454305-1	2008	PURPOSE: Our objective was to determine the effect of the flavonoid biochanin A (BCA), administered alone or in combination with the flavonoids quercetin and epigallocatechin-3-gallate (EGCG), on the growth of human breast cancer MCF-7 cells in a murine xenograft animal model.	Flavonoids	58-67	B cell linker	Homo sapiens	68-79
18532978-0	2008	MYBL2 is a new regulator of flavonoid biosynthesis in Arabidopsis thaliana.	Flavonoids	28-37	MYB-like 2	Arabidopsis thaliana	0-5
18532978-5	2008	The genetic and molecular analyses presented here demonstrated that Arabidopsis MYBL2, which encodes a R3-MYB-related protein, is involved in the regulation of flavonoid biosynthesis.	Flavonoids	160-169	MYB-like 2	Arabidopsis thaliana	80-85
18532978-9	2008	Interestingly, transient expression analyses in A. thaliana cells suggested that MYBL2 interacts with MBW complexes in planta and directly modulates the expression of flavonoid target genes.	Flavonoids	167-176	MYB-like 2	Arabidopsis thaliana	81-86
18396148-3	2008	While the survival-promoting effect of several of the fisetin-related flavonoids was partially dependent on ERK activation, the effect of fisetin was not.	Flavonoids	70-80	Eph receptor B1	Rattus norvegicus	108-111
18645237-1	2008	Dihydroflavonol 4-reductase (DFR) is a key enzyme of the flavonoid biosynthesis pathway which catalyses the NADPH-dependent reduction of 2R,3R-trans-dihydroflavonols to leucoanthocyanidins.	Flavonoids	57-66	dihydroflavonol 4-reductase	Vitis vinifera	0-27
18700978-3	2008	The aim of the present study was cloning, sequence analysis, mapping and expression analysis of F3H (flavanone 3-hydroxylase - one of the key enzymes in the plant flavonoid biosynthesis pathway) homoeologues in bread wheat and study of the interaction between F3H and their regulatory genes homoeologues - Rc (red coleoptiles).	Flavonoids	163-172	flavanone 3-dioxygenase 2	Triticum aestivum	96-124
18590707-6	2008	Inducible nitric oxide synthase expression was also blocked largely by some flavonoids, especially quercetin, luteolin and apigenin, while cyclooxygenase 2 was downregulated only by apigenin, diosmetin and quercetin.	Flavonoids	76-86	nitric oxide synthase 2	Rattus norvegicus	0-31
18645237-1	2008	Dihydroflavonol 4-reductase (DFR) is a key enzyme of the flavonoid biosynthesis pathway which catalyses the NADPH-dependent reduction of 2R,3R-trans-dihydroflavonols to leucoanthocyanidins.	Flavonoids	57-66	dihydroflavonol 4-reductase	Vitis vinifera	29-32
18639462-0	2008	Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity.	Flavonoids	20-29	cyclin dependent kinase 1	Homo sapiens	43-47
18565494-0	2008	Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9.	Flavonoids	19-29	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	45-51
18565494-0	2008	Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9.	Flavonoids	19-29	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	56-62
18565494-3	2008	In this paper, we tested the glucuronidation of nineteen flavonoids by both recombinant human UGT1A3 and UGT1A9.	Flavonoids	57-67	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	94-100
18565494-3	2008	In this paper, we tested the glucuronidation of nineteen flavonoids by both recombinant human UGT1A3 and UGT1A9.	Flavonoids	57-67	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	105-111
18565494-7	2008	Enzymatic kinetic analysis indicated that the catalyzing efficiency (Vmax/Km) of UGT1A9 was higher than that of UGT1A3, suggesting its important role in flavonoid glucuronidation.	Flavonoids	153-162	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	81-87
18565494-7	2008	Enzymatic kinetic analysis indicated that the catalyzing efficiency (Vmax/Km) of UGT1A9 was higher than that of UGT1A3, suggesting its important role in flavonoid glucuronidation.	Flavonoids	153-162	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	112-118
18565494-8	2008	Both human UGT1A3 and UGT1A9 preferred flavonoid aglycone to flavonoid glycoside, and their metabolism to arabinoside was stronger than to other glycosides.	Flavonoids	39-48	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	11-17
18565494-8	2008	Both human UGT1A3 and UGT1A9 preferred flavonoid aglycone to flavonoid glycoside, and their metabolism to arabinoside was stronger than to other glycosides.	Flavonoids	39-48	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	22-28
18585047-0	2008	QSAR prediction of inhibition of aldose reductase for flavonoids.	Flavonoids	54-64	aldo-keto reductase family 1 member B	Homo sapiens	33-49
18585047-1	2008	We performed a predictive analysis based on quantitative structure-activity relationships (QSAR) of an important property of flavonoids, which is the inhibition (IC(50)) of aldose reductase (AR).	Flavonoids	125-135	aldo-keto reductase family 1 member B	Homo sapiens	173-189
18585047-1	2008	We performed a predictive analysis based on quantitative structure-activity relationships (QSAR) of an important property of flavonoids, which is the inhibition (IC(50)) of aldose reductase (AR).	Flavonoids	125-135	aldo-keto reductase family 1 member B	Homo sapiens	93-95
18585047-4	2008	As a practical application, we used the obtained QSAR model to predict the AR inhibitory effect of newly synthesized flavonoids that present 2-, 7-substitutions in the benzopyrane backbone.	Flavonoids	117-127	aldo-keto reductase family 1 member B	Homo sapiens	51-53
18650094-4	2008	Here, the flavonoid baicalin was isolated as the active component of an extract of Scutellaria baicalensis roots having prolyl oligopeptidase inhibitory activity.	Flavonoids	10-19	prolyl endopeptidase	Homo sapiens	120-141
18639462-0	2008	Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity.	Flavonoids	20-29	sarcosine dehydrogenase	Homo sapiens	80-83
18620432-10	2008	The current study provides the structure-activity relationships for flavonoids as the anti-inflammatory dietary constituents targeting the MPO-derived oxidative reactions in vivo.	Flavonoids	68-78	myeloperoxidase	Homo sapiens	139-142
18620432-0	2008	Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites.	Flavonoids	0-10	myeloperoxidase	Homo sapiens	43-58
18573104-2	2008	A genomics approach was used to identify the gene MdPGT1 in apple (Malus x domestica) with homology to the UDP-glycosyltransferase 88 family of uridine diphosphate glycosyltransferases that show specificity towards flavonoid substrates.	Flavonoids	215-224	phloretin 2'-O-glucosyltransferase	Malus domestica	50-56
18499676-5	2008	We report here the specific disruption of PGP1-TWD1 interaction by NPA and flavonoids using bioluminescence resonance energy transfer with flavonoids functioning as a classical established inhibitor of mammalian and plant PGPs.	Flavonoids	75-85	CD44 molecule (Indian blood group)	Homo sapiens	42-46
18620432-3	2008	In this study, we examined the molecular basis of the inhibitory effects of dietary flavonoids, such as quercetin, and their metabolites on the catalytic reaction of MPO using a combination of biological assays and theoretical calculation studies.	Flavonoids	84-94	myeloperoxidase	Homo sapiens	166-169
18757557-4	2008	Candidate genes presumably involved in the flavonoid pathway were delimited by transcriptome coexpression network analysis using public databases, leading to the detailed analysis of two flavonoid pathway genes, UGT78D3 (At5g17030) and RHM1 (At1g78570).	Flavonoids	43-52	UDP-glucosyl transferase 78D3	Arabidopsis thaliana	212-219
18499676-5	2008	We report here the specific disruption of PGP1-TWD1 interaction by NPA and flavonoids using bioluminescence resonance energy transfer with flavonoids functioning as a classical established inhibitor of mammalian and plant PGPs.	Flavonoids	139-149	CD44 molecule (Indian blood group)	Homo sapiens	42-46
18539781-4	2008	VvMYB5b encodes a protein belonging to the R2R3-MYB family of transcription factors and displays significant similarity with VvMYB5a, another MYB factor recently shown to regulate flavonoid synthesis in grapevine.	Flavonoids	180-189	MYB5b	Vitis vinifera	0-7
18539781-4	2008	VvMYB5b encodes a protein belonging to the R2R3-MYB family of transcription factors and displays significant similarity with VvMYB5a, another MYB factor recently shown to regulate flavonoid synthesis in grapevine.	Flavonoids	180-189	uncharacterized protein LOC107775040	Nicotiana tabacum	2-5
18539781-5	2008	The ability of VvMYB5a and VvMYB5b to activate the grapevine promoters of several structural genes of the flavonoid pathway was confirmed by transient expression of the corresponding cDNAs in grape cells.	Flavonoids	106-115	MYB5b	Vitis vinifera	27-34
18539781-6	2008	Overexpression of VvMYB5b in tobacco (Nicotiana tabacum) leads to an up-regulation of genes encoding enzymes of the flavonoid pathway and results in the accumulation of anthocyanin- and proanthocyanidin-derived compounds.	Flavonoids	116-125	MYB5b	Vitis vinifera	18-25
18757557-4	2008	Candidate genes presumably involved in the flavonoid pathway were delimited by transcriptome coexpression network analysis using public databases, leading to the detailed analysis of two flavonoid pathway genes, UGT78D3 (At5g17030) and RHM1 (At1g78570).	Flavonoids	43-52	rhamnose biosynthesis 1	Arabidopsis thaliana	236-240
18757557-4	2008	Candidate genes presumably involved in the flavonoid pathway were delimited by transcriptome coexpression network analysis using public databases, leading to the detailed analysis of two flavonoid pathway genes, UGT78D3 (At5g17030) and RHM1 (At1g78570).	Flavonoids	187-196	UDP-glucosyl transferase 78D3	Arabidopsis thaliana	212-219
18757557-4	2008	Candidate genes presumably involved in the flavonoid pathway were delimited by transcriptome coexpression network analysis using public databases, leading to the detailed analysis of two flavonoid pathway genes, UGT78D3 (At5g17030) and RHM1 (At1g78570).	Flavonoids	187-196	rhamnose biosynthesis 1	Arabidopsis thaliana	236-240
18567747-6	2008	Transcriptional regulation of the LDLR gene by citrus flavonoids has been implicated but, to our knowledge, not directly demonstrated.	Flavonoids	54-64	low density lipoprotein receptor	Homo sapiens	34-38
18579125-0	2008	Flavonoids as inhibitors of human carbonyl reductase 1.	Flavonoids	0-10	carbonyl reductase 1	Homo sapiens	34-54
18579125-7	2008	Computational docking experiments of the four best inhibitors to the catalytic site of CBR1 showed that the flavonoid skeleton structure was the binding part of the molecule.	Flavonoids	108-117	carbonyl reductase 1	Homo sapiens	87-91
18420779-0	2008	Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications.	Flavonoids	71-81	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-29
18831918-4	2008	We recently showed that the natural flavonoids quercetin and luteolin can eliminate "flush", as well as inhibit both niacin-induced plasma prostaglandin D2 (PGD2) and serotonin increase in an animal model.	Flavonoids	36-46	prostaglandin D2 synthase	Homo sapiens	139-155
18567747-0	2008	The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells.	Flavonoids	11-21	low density lipoprotein receptor	Homo sapiens	71-103
18449627-4	2008	We also characterized CBR1 inhibition by the related flavonoids triHER and quercetin.	Flavonoids	53-63	carbonyl reductase 1	Homo sapiens	22-26
19704584-7	2008	Here we show the movement of endogenous flavonoids by using reciprocal grafting experiments between tt4 and wild-type seedlings.	Flavonoids	40-50	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	100-103
18467451-1	2008	The genome of Arabidopsis (Arabidopsis thaliana) contains five sequences with high similarity to FLAVONOL SYNTHASE1 (AtFLS1), a previously characterized flavonol synthase gene that plays a central role in flavonoid metabolism.	Flavonoids	205-214	flavonol synthase 1	Arabidopsis thaliana	117-123
18467451-4	2008	AtFLS1 also appears to be the only member of this group that influences flavonoid levels and the root gravitropic response in seedlings under nonstressed conditions.	Flavonoids	72-81	flavonol synthase 1	Arabidopsis thaliana	0-6
18507367-1	2008	In this study we investigated the structural requirements for inhibition of human salivary alpha-amylase by flavonoids.	Flavonoids	108-118	amylase alpha 1A	Homo sapiens	82-104
18507367-2	2008	Four flavonols and three flavones, out of the 19 flavonoids tested, exhibited IC50 values less than 100 microM against human salivary alpha-amylase activity.	Flavonoids	49-59	amylase alpha 1A	Homo sapiens	125-147
18492823-12	2008	These data provide evidence that the interplay between p38MAPK and JAK-STAT pathways is involved in dietary flavonoid protection against oxidized LDL through hampering MAPK-dependent pathways involving the activation of JAK2.	Flavonoids	108-117	Janus kinase 2	Homo sapiens	220-224
18504708-1	2008	Resveratrol is a bioflavonoid which is known to inhibit cell proliferation and induce apoptosis in cancer cell lines at concentrations above 50 muM.	Flavonoids	17-29	latexin	Homo sapiens	144-147
19704584-4	2008	The localised application of selective flavonoids to tt4 mutants such as naringenin, dihydrokaempferol and dihydroquercetin showed that they were taken up at the root tip, mid-root or cotyledons and travelled long distances via cell-to-cell movement to distal tissues and converted to quercetin and kaempferol.	Flavonoids	39-49	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	53-56
18494482-0	2008	Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase.	Flavonoids	36-46	glycogen phosphorylase L	Rattus norvegicus	74-96
18494482-4	2008	In the present study, we focused on inhibition of glycogen phosphorylase (GP) by flavonoids.	Flavonoids	81-91	glycogen phosphorylase L	Rattus norvegicus	50-72
18439428-13	2008	CONCLUSIONS: The cisplatin-induced decreases of the plasma acylated-ghrelin level and food intake are mediated by 5-HT2B/2C receptors and suppressed by flavonoids in rikkunshito.	Flavonoids	152-162	ghrelin and obestatin prepropeptide	Rattus norvegicus	68-75
18492835-14	2008	The flavonoid quercetin enhances barrier function via transcriptional expression regulation of the TJ protein claudin-4, which represents an important protective effect of this food component against barrier disturbance in intestinal inflammation.	Flavonoids	4-13	claudin 4	Homo sapiens	110-119
18567791-5	2008	Blocking flavonoid biosynthesis suppresses the rol1-2 shoot phenotype, suggesting that it is induced by the modified flavonol profile.	Flavonoids	9-18	rhamnose biosynthesis 1	Arabidopsis thaliana	47-51
18454540-5	2008	Our results suggest that the common dietary flavonoid, quercetin, and some of its major in vivo metabolites are potential inhibitors of MPO at physiological concentrations.	Flavonoids	44-53	myeloperoxidase	Homo sapiens	136-139
18443422-3	2008	Previously, UGT71C1 was shown to glycosylate the 3-OH of hydroxycinnamates and flavonoids in vitro.	Flavonoids	79-89	UDP-glucosyl transferase 71C1	Arabidopsis thaliana	12-19
18443422-10	2008	Taken together, our results indicate that ugt71c1-1 has increased resistance to oxidative stress, suggesting that UGT71C1 plays a role in some glycosylation pathways affecting secondary metabolites such as flavonoids in response to oxidative stress.	Flavonoids	206-216	UDP-glucosyl transferase 71C1	Arabidopsis thaliana	42-49
18443422-10	2008	Taken together, our results indicate that ugt71c1-1 has increased resistance to oxidative stress, suggesting that UGT71C1 plays a role in some glycosylation pathways affecting secondary metabolites such as flavonoids in response to oxidative stress.	Flavonoids	206-216	UDP-glucosyl transferase 71C1	Arabidopsis thaliana	114-121
18440819-7	2008	Further in vitro-antioxidant activities of flavonoids were evaluated with rat liver catalase by gel electrophoresis.	Flavonoids	43-53	catalase	Rattus norvegicus	84-92
18454540-6	2008	Dietary flavonoids that could modify MPO activity could protect lipoproteins from damage in chronic inflammatory states such as cardiovascular disease.	Flavonoids	8-18	myeloperoxidase	Homo sapiens	37-40
18295609-3	2008	In this study, we discovered that natural flavonoids act as non-peptidic BACE-1 inhibitors and potently inhibit BACE-1 activity and reduce the level of secreted Abeta in primary cortical neurons.	Flavonoids	42-52	beta-secretase 1	Homo sapiens	73-79
17766004-6	2008	Experiments with transgenic lines over-expressing the MYB factors show that PAP1, but not PAP2, strongly stimulates expression of the anthocyanin structural gene encoding dihydroflavonol reductase, but neither factor affected expression of the early flavonoid biosynthesis gene encoding chalcone synthase.	Flavonoids	250-259	phosphatidic acid phosphatase 1	Arabidopsis thaliana	76-80
18359480-2	2008	The present work demonstrates that the flavonoids quercetin and chrysin cooperate with ATO to induce apoptosis in U937 promonocytes and other human leukemia cell lines (THP-1, HL-60).	Flavonoids	39-49	GLI family zinc finger 2	Homo sapiens	169-174
18295609-3	2008	In this study, we discovered that natural flavonoids act as non-peptidic BACE-1 inhibitors and potently inhibit BACE-1 activity and reduce the level of secreted Abeta in primary cortical neurons.	Flavonoids	42-52	beta-secretase 1	Homo sapiens	112-118
18295609-3	2008	In this study, we discovered that natural flavonoids act as non-peptidic BACE-1 inhibitors and potently inhibit BACE-1 activity and reduce the level of secreted Abeta in primary cortical neurons.	Flavonoids	42-52	amyloid beta precursor protein	Homo sapiens	161-166
18295609-4	2008	In addition, we demonstrated the calculated docking poses of flavonoids to BACE-1 and revealed the interactions of flavonoids with the BACE-1 catalytic center.	Flavonoids	61-71	beta-secretase 1	Homo sapiens	75-81
18295609-4	2008	In addition, we demonstrated the calculated docking poses of flavonoids to BACE-1 and revealed the interactions of flavonoids with the BACE-1 catalytic center.	Flavonoids	115-125	beta-secretase 1	Homo sapiens	135-141
17927845-12	2008	All the flavonoids and OleA inhibited cAMP-PDE, whereas HT, TY, HVA (100 microm) were inactive.	Flavonoids	8-18	aldehyde dehydrogenase 7 family member A1	Homo sapiens	43-46
18473744-6	2008	SULTs 1A3 and 2A1 were less strongly inhibited by flavonoids or isoflavonoids although tricin (3",5"-dimethoxy-4",5,7-trihydroxyflavone is a competitive inhibitor of SULT 1E1 with an inhibition constant of approximately 1 nM.	Flavonoids	50-60	sulfotransferase family 1A member 3	Homo sapiens	0-17
18449225-0	2008	Flavonoid-responsive nodY-lacZ expression in three phylogenetically different Bradyrhizobium groups.	Flavonoids	0-9	nodY	Bradyrhizobium diazoefficiens USDA 110	21-25
18449225-5	2008	Differences in nodY-lacZ expression among the strains in response to 37 flavonoid compounds at various concentrations were evaluated.	Flavonoids	72-81	nodY	Bradyrhizobium diazoefficiens USDA 110	15-19
18473744-5	2008	Studies on these isoforms with a range of environmental chemicals and dietary components have shown that SULT 1A1 is significantly inhibited by flavonoids; all flavones and flavonols with a 3",4"-dihydroxy motif had an IC(50) of &lt; 100 nm against 3 microM 4-nitrophenol as the standard substrate.	Flavonoids	144-154	sulfotransferase family 1A member 1	Homo sapiens	105-113
18503736-2	2008	It is likely that flavonoids exert such effects, through selective actions on different components of a number of protein kinase and lipid kinase signalling cascades, such as the phosphatidylinositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase (MAPK) pathways.	Flavonoids	18-28	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	179-208
18503736-2	2008	It is likely that flavonoids exert such effects, through selective actions on different components of a number of protein kinase and lipid kinase signalling cascades, such as the phosphatidylinositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase (MAPK) pathways.	Flavonoids	18-28	AKT serine/threonine kinase 1	Homo sapiens	216-219
18344529-2	2008	Our objectives were to carry out metabolic and molecular characterization of this genotype, emphasizing its interaction with the high pigment-1 (hp-1) mutation, known to increase flavonoids in tomato fruits.	Flavonoids	179-189	DNA damage-binding protein 1	Solanum lycopersicum	129-149
18234413-12	2008	Our study reveals that important differences exist between flavonoids with different structural features in their capacity to abrogate the generation of different ROS/RNS, and suggests that the modulation of antioxidant enzymes by flavonoids may be also important in their antioxidant effects in liver cells.	Flavonoids	59-69	FAM20C golgi associated secretory pathway kinase	Homo sapiens	167-170
18234413-12	2008	Our study reveals that important differences exist between flavonoids with different structural features in their capacity to abrogate the generation of different ROS/RNS, and suggests that the modulation of antioxidant enzymes by flavonoids may be also important in their antioxidant effects in liver cells.	Flavonoids	231-241	FAM20C golgi associated secretory pathway kinase	Homo sapiens	167-170
18398903-4	2008	Flavonoids modulate various CYPs involved in carcinogen activation and scavenging reactive species formed from carcinogens by CYP-mediated reactions.	Flavonoids	0-10	peptidylprolyl isomerase G	Homo sapiens	28-31
18363648-3	2008	The production of these signal molecules is dependent on plant flavonoids which trigger a regulatory cascade controlled by the transcriptional activators NodD1, NodD2, SyrM2 and TtsI.	Flavonoids	63-73	transcriptional regulator NodD1	Sinorhizobium fredii NGR234	154-159
18363648-3	2008	The production of these signal molecules is dependent on plant flavonoids which trigger a regulatory cascade controlled by the transcriptional activators NodD1, NodD2, SyrM2 and TtsI.	Flavonoids	63-73	transcriptional regulator NodD2	Sinorhizobium fredii NGR234	161-166
18363648-3	2008	The production of these signal molecules is dependent on plant flavonoids which trigger a regulatory cascade controlled by the transcriptional activators NodD1, NodD2, SyrM2 and TtsI.	Flavonoids	63-73	LysR family transcriptional regulator	Sinorhizobium fredii NGR234	168-173
18363648-3	2008	The production of these signal molecules is dependent on plant flavonoids which trigger a regulatory cascade controlled by the transcriptional activators NodD1, NodD2, SyrM2 and TtsI.	Flavonoids	63-73	response regulator	Sinorhizobium fredii NGR234	178-182
18363648-6	2008	Expression profiles of lacZ fusions to these tts boxes showed that they are part of a TtsI-dependent regulon induced by plant-derived flavonoids.	Flavonoids	134-144	response regulator	Sinorhizobium fredii NGR234	86-90
18031469-7	2008	PAP1/2 stimulate gross activation of the flavonoid pathway, and different investigations support merging signal transduction chains for various abiotic treatments on PAP1/2.	Flavonoids	41-50	purple acid phosphatase 12	Arabidopsis thaliana	0-6
18031469-7	2008	PAP1/2 stimulate gross activation of the flavonoid pathway, and different investigations support merging signal transduction chains for various abiotic treatments on PAP1/2.	Flavonoids	41-50	purple acid phosphatase 12	Arabidopsis thaliana	166-172
18412998-5	2008	Of particular interest is the ability of flavonoids to activate the extracellular signal-regulated kinase and the Akt signalling pathways leading to the activation of the cAMP-response element-binding protein, a transcription factor responsible for increasing the expression of a number of neurotrophins important in LTP and long-term memory.	Flavonoids	41-51	AKT serine/threonine kinase 1	Homo sapiens	114-117
18398903-7	2008	Since cytochromes P450, P-gp and phase-II enzymes are involved in the metabolism of drugs and in the processes of chemical carcinogenesis, interactions of flavonoids with these systems hold great promise for their therapeutic potential.	Flavonoids	155-165	phosphoglycolate phosphatase	Homo sapiens	24-28
23105746-4	2008	The results showed a significant fall in the SOD levels in the second follow up of group B.Glucose 6 phosphate dehydrogenase showed significant increase only in the first follow up of patients who received Ocimum flavonoids.	Flavonoids	213-223	glucose-6-phosphate dehydrogenase	Homo sapiens	91-124
18449498-0	2008	Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg.	Flavonoids	105-115	cytochrome c oxidase II, mitochondrial	Mus musculus	84-89
18067462-0	2008	Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin.	Flavonoids	61-70	pirin	Homo sapiens	13-18
18067462-5	2008	Overexpression of pirin reduced antiviral inhibitory effect of quercetin, while siRNA-induced suppression of pirin level made poliovirus replication more sensitive to the flavonoid.	Flavonoids	171-180	pirin	Homo sapiens	109-114
18201740-0	2008	Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study.	Flavonoids	47-57	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
18201740-3	2008	Certain flavonoids, plant derived chemicals, are known catalytic aromatase inhibitors.	Flavonoids	8-18	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	65-74
17973296-0	2008	Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.	Flavonoids	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-79
18258440-0	2008	Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects.	Flavonoids	66-76	glyoxalase I	Homo sapiens	41-46
18258440-5	2008	These compounds were examined the inhibitory abilities to human GLO I activity and analyzed their structure-activity relationships to determine an important pharmacophore of flavonoids for the human GLO I binding.	Flavonoids	174-184	glyoxalase I	Homo sapiens	199-204
18258440-6	2008	Our results point to the contribution of hydroxy groups at the B ring of flavonoids to the effective inhibition of the human GLO I.	Flavonoids	73-83	glyoxalase I	Homo sapiens	125-130
18258440-7	2008	Based on the binding mode of flavonoids, we constructed the human GLO I/inhibitor pharmacophore.	Flavonoids	29-39	glyoxalase I	Homo sapiens	66-71
18258440-8	2008	This work delivers the first three-dimensional (3D) structural data and explains certain flavonoids interact specifically with the human GLO I.	Flavonoids	89-99	glyoxalase I	Homo sapiens	137-142
18361512-2	2008	Previously, potency of induction of NQO1 has been linearly correlated with the ability to release an electron from different classes of inducers, including diphenols, phenylpropenoids, and flavonoids.	Flavonoids	189-199	NAD(P)H quinone dehydrogenase 1	Homo sapiens	36-40
18361512-3	2008	In the present work, we focus on the induction of NQO1 by diphenols, which we consider as a model underlying the mechanisms of action of other phenolic inducers such as phenylpropenoids and flavonoids.	Flavonoids	190-200	NAD(P)H quinone dehydrogenase 1	Homo sapiens	50-54
18191104-0	2008	Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes.	Flavonoids	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-112
18356331-0	2008	Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults.	Flavonoids	78-87	C-reactive protein	Homo sapiens	6-24
18356331-3	2008	We aimed to test the associations between dietary flavonoid intake and serum CRP concentrations among U.S. adults after adjusting for dietary, sociodemographic, and lifestyle factors.	Flavonoids	50-59	C-reactive protein	Homo sapiens	77-80
18356331-10	2008	Among the flavonoid compounds investigated, quercetin, kaempferol, malvidin, peonidin, daidzein, and genistein had inverse associations with serum CRP concentration (P &lt; 0.05).	Flavonoids	10-19	C-reactive protein	Homo sapiens	147-150
18356331-12	2008	Our findings demonstrate that intake of dietary flavonoids is inversely associated with serum CRP concentrations in U.S. adults.	Flavonoids	48-58	C-reactive protein	Homo sapiens	94-97
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Flavonoids	14-24	vascular endothelial growth factor A	Homo sapiens	62-66
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Flavonoids	14-24	epidermal growth factor receptor	Homo sapiens	102-106
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Flavonoids	14-24	nuclear factor kappa B subunit 1	Homo sapiens	119-127
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Flavonoids	14-24	AKT serine/threonine kinase 1	Homo sapiens	135-138
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Flavonoids	14-24	mitogen-activated protein kinase 3	Homo sapiens	140-146
18191104-0	2008	Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes.	Flavonoids	0-10	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	117-123
18191104-1	2008	We evaluated the effects of increasing concentrations of the flavonoids salvigenin, diosmetin and luteolin on the in vitro metabolism of midazolam (MDZ), a probe substrate for cytochrome P450 (CYP) 3A enzymes, which is converted into 1"-hydroxy-midazolam (1"-OH-MDZ) and 4-hydroxy-midazolam (4-OH-MDZ) by human liver microsomes.	Flavonoids	61-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	176-200
18323654-3	2008	In the present study, we attempted to reactivate p53 in HepG2 retaining wild-type p53 by quercetin, an ubiquitous bioactive plant flavonoid.	Flavonoids	130-139	tumor protein p53	Homo sapiens	49-52
17880982-2	2008	Dietary flavonoids have been shown to have anti-inflammatory properties, decreasing the expression of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells.	Flavonoids	8-18	vascular cell adhesion molecule 1	Homo sapiens	135-168
17880982-2	2008	Dietary flavonoids have been shown to have anti-inflammatory properties, decreasing the expression of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells.	Flavonoids	8-18	vascular cell adhesion molecule 1	Homo sapiens	170-176
17880982-2	2008	Dietary flavonoids have been shown to have anti-inflammatory properties, decreasing the expression of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells.	Flavonoids	8-18	intercellular adhesion molecule 1	Homo sapiens	182-215
17880982-2	2008	Dietary flavonoids have been shown to have anti-inflammatory properties, decreasing the expression of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells.	Flavonoids	8-18	intercellular adhesion molecule 1	Homo sapiens	217-223
18078968-0	2008	Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD.	Flavonoids	64-73	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-123
18078968-5	2008	Previously, we found that inhibition of JNK activity promotes flavonoid-mediated apoptosis of human osteosarcoma cells.	Flavonoids	62-71	mitogen-activated protein kinase 8	Homo sapiens	40-43
18078968-7	2008	As the results, quercetin and genistein as well as a flavonoid fraction induced apoptosis of tumor cells, which was further accelerated by specific JNK inhibitor, SP600125 or by small interfering RNA specific to JNK1/2.	Flavonoids	53-62	mitogen-activated protein kinase 8	Homo sapiens	148-151
18078968-7	2008	As the results, quercetin and genistein as well as a flavonoid fraction induced apoptosis of tumor cells, which was further accelerated by specific JNK inhibitor, SP600125 or by small interfering RNA specific to JNK1/2.	Flavonoids	53-62	mitogen-activated protein kinase 8	Homo sapiens	212-218
18078968-9	2008	Inhibition of JNK by SP600125 also reduced flavonoid-stimulated nuclear induction of JunD which was known to have protective role in apoptosis, whereas JNK inhibition alone had little effect on apoptosis.	Flavonoids	43-52	mitogen-activated protein kinase 8	Homo sapiens	14-17
18078968-9	2008	Inhibition of JNK by SP600125 also reduced flavonoid-stimulated nuclear induction of JunD which was known to have protective role in apoptosis, whereas JNK inhibition alone had little effect on apoptosis.	Flavonoids	43-52	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-89
18078968-10	2008	The flavonoid-induced apoptosis of tumor cells was significantly enhanced by transfecting them with antisense JunD oligonucleotides.	Flavonoids	4-13	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-114
18078968-11	2008	These results suggest that inhibition of JNK facilitates flavonoid-induced apoptosis through down-regulation of JunD, which is further sensitive to tumor cells.	Flavonoids	57-66	mitogen-activated protein kinase 8	Homo sapiens	41-44
18078968-11	2008	These results suggest that inhibition of JNK facilitates flavonoid-induced apoptosis through down-regulation of JunD, which is further sensitive to tumor cells.	Flavonoids	57-66	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-116
18078968-12	2008	Therefore, combination with a specific JNK inhibitor further enhances the anti-cancer and chemopreventive potential of bio-flavonoids.	Flavonoids	123-133	mitogen-activated protein kinase 8	Homo sapiens	39-42
18061585-6	2008	Furthermore, when cells in which HIF-1 had been induced by DFO were also treated with flavonoids, the transcriptional activity of HIF-1 was strongly impaired without simultaneous reduction in HIF-1alpha protein levels.	Flavonoids	86-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-38
18619247-6	2008	Among these fractions, flavonoids from Prinsepia utilis Royle significantly reduced GLU, TG and AST level in diabetic mice compared with model control group (P&lt;0.01), markedly reduced VLDL-C, ALT and BUN level in diabetic mice compared with model control group (P&lt;0.05), but had little influence on TC.	Flavonoids	23-33	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	96-99
18619247-6	2008	Among these fractions, flavonoids from Prinsepia utilis Royle significantly reduced GLU, TG and AST level in diabetic mice compared with model control group (P&lt;0.01), markedly reduced VLDL-C, ALT and BUN level in diabetic mice compared with model control group (P&lt;0.05), but had little influence on TC.	Flavonoids	23-33	glutamic pyruvic transaminase, soluble	Mus musculus	195-198
18061585-0	2008	Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.	Flavonoids	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
18061585-2	2008	In this study we investigated the ability of plant flavonoids to induce HIF-1alpha and regulate HIF-1 transcriptional activity in HeLa cells.	Flavonoids	51-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-82
18061585-2	2008	In this study we investigated the ability of plant flavonoids to induce HIF-1alpha and regulate HIF-1 transcriptional activity in HeLa cells.	Flavonoids	51-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-77
18061585-6	2008	Furthermore, when cells in which HIF-1 had been induced by DFO were also treated with flavonoids, the transcriptional activity of HIF-1 was strongly impaired without simultaneous reduction in HIF-1alpha protein levels.	Flavonoids	86-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-135
18061585-3	2008	We demonstrate for the first time that the flavonoids baicalein, luteolin and fisetin, as well as the previously investigated quercetin, induce HIF-1alpha under normal oxygen pressure, whereas kaempferol, taxifolin, and rutin are inactive.	Flavonoids	43-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
18061585-4	2008	We further reveal that the capability of flavonoids to bind efficiently intracellular iron and their lipophilicity are essential for HIF-1alpha induction.	Flavonoids	41-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-143
18061585-6	2008	Furthermore, when cells in which HIF-1 had been induced by DFO were also treated with flavonoids, the transcriptional activity of HIF-1 was strongly impaired without simultaneous reduction in HIF-1alpha protein levels.	Flavonoids	86-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	192-202
18061585-5	2008	Despite the ability of flavonoids to stabilize HIF-1alpha, the transcriptional activity of HIF-1 induced by flavonoids was significantly lower than that observed with the iron chelator and known HIF-1 inducer, desferrioxamine (DFO).	Flavonoids	23-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
18061585-5	2008	Despite the ability of flavonoids to stabilize HIF-1alpha, the transcriptional activity of HIF-1 induced by flavonoids was significantly lower than that observed with the iron chelator and known HIF-1 inducer, desferrioxamine (DFO).	Flavonoids	23-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-52
18061585-5	2008	Despite the ability of flavonoids to stabilize HIF-1alpha, the transcriptional activity of HIF-1 induced by flavonoids was significantly lower than that observed with the iron chelator and known HIF-1 inducer, desferrioxamine (DFO).	Flavonoids	108-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-96
18061585-7	2008	Localization of HIF-1alpha by immuno- and direct fluorescence microscopy and in vitro phosphorylation assays suggest that flavonoids inhibit HIF-1 activity by impairing the MAPK-dependent phosphorylation of HIF-1alpha, thereby decreasing its nuclear accumulation.	Flavonoids	122-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-26
18061585-7	2008	Localization of HIF-1alpha by immuno- and direct fluorescence microscopy and in vitro phosphorylation assays suggest that flavonoids inhibit HIF-1 activity by impairing the MAPK-dependent phosphorylation of HIF-1alpha, thereby decreasing its nuclear accumulation.	Flavonoids	122-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
18061585-7	2008	Localization of HIF-1alpha by immuno- and direct fluorescence microscopy and in vitro phosphorylation assays suggest that flavonoids inhibit HIF-1 activity by impairing the MAPK-dependent phosphorylation of HIF-1alpha, thereby decreasing its nuclear accumulation.	Flavonoids	122-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	207-217
18063365-0	2008	A flavonoid gossypin binds to cyclin-dependent kinase 2.	Flavonoids	2-11	cyclin dependent kinase 2	Homo sapiens	30-55
17933522-2	2008	A range of environmental phenolic contaminants and dietary flavonoids was tested for inhibition of the human SULT 1A1, 1E1 and 2A1 isoforms.	Flavonoids	59-69	sulfotransferase family 1A member 1	Homo sapiens	109-130
17933522-5	2008	In a small pilot study to determine whether ingestion of soy flavonoids would affect SULT1A1 activity in vivo as well as in vitro, sulfonation of daidzein was reduced in a group of women "at risk" of breast cancer, as compared with controls, although the SULT 1A1*1/SULT 1A1*2 allele ratio was not different.	Flavonoids	61-71	sulfotransferase family 1A member 1	Homo sapiens	85-92
18506592-3	2008	Besides the development of synthetic compounds, several naturally occurring and synthetic flavonoids, which are ubiquitous natural phenolic compounds and mediate the host of biological activities, are found to demonstrate inhibitory effects on aromatase.	Flavonoids	90-100	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	244-253
18032389-8	2008	Taken together, these studies suggest a novel mechanism for flavonoid-induced cytoprotection in SH-SY5Y cells involving SREBP-2-mediated sterol synthesis that decreases lipid peroxidation by maintaining membrane integrity in the presence of oxidative stress.	Flavonoids	60-69	sterol regulatory element binding transcription factor 2	Homo sapiens	120-127
18048013-4	2008	The flavonoid fisetin protects against the SIN-1-mediated alterations in ERK/c-Myc phosphorylation, nuclear Nrf2 levels, glutamate cysteine ligase levels, GSH concentration and cell viability.	Flavonoids	4-13	MAPK associated protein 1	Homo sapiens	43-48
18048013-4	2008	The flavonoid fisetin protects against the SIN-1-mediated alterations in ERK/c-Myc phosphorylation, nuclear Nrf2 levels, glutamate cysteine ligase levels, GSH concentration and cell viability.	Flavonoids	4-13	Eph receptor B1	Rattus norvegicus	73-76
18048013-4	2008	The flavonoid fisetin protects against the SIN-1-mediated alterations in ERK/c-Myc phosphorylation, nuclear Nrf2 levels, glutamate cysteine ligase levels, GSH concentration and cell viability.	Flavonoids	4-13	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	77-82
18048013-4	2008	The flavonoid fisetin protects against the SIN-1-mediated alterations in ERK/c-Myc phosphorylation, nuclear Nrf2 levels, glutamate cysteine ligase levels, GSH concentration and cell viability.	Flavonoids	4-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
18239283-6	2008	Like flavonoids, diazepam inhibited the release of vascular endothelial growth factor (VEGF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) into supernatants of cultured in the SNU-C4 and MDA-MB-231 cells.	Flavonoids	5-15	vascular endothelial growth factor A	Homo sapiens	87-91
18226198-9	2008	Pretreatment of isolated hepatocytes with flavonoids abrogated the CCl4 effects on the cell membrane integrity and normalized the ceramide content.	Flavonoids	42-52	C-C motif chemokine ligand 4	Rattus norvegicus	67-71
18226198-11	2008	CONCLUSION: The data obtained have demonstrated that flavonoids affect sphingolipid metabolism in the CCl4- and ethanol-damaged liver and liver cells.	Flavonoids	53-63	C-C motif chemokine ligand 4	Rattus norvegicus	102-106
18063365-2	2008	In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2.	Flavonoids	17-27	cyclin dependent kinase 2	Homo sapiens	36-61
18063365-2	2008	In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2.	Flavonoids	17-27	cyclin dependent kinase 2	Homo sapiens	63-67
18063365-2	2008	In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2.	Flavonoids	17-27	cyclin dependent kinase 2	Homo sapiens	158-162
17961621-2	2008	The diet-derived flavonoids have been reported to possess anti-invasion properties; however, knowledge on the pharmacological and molecular mechanisms in suppressing HGF/Met-mediated tumor invasion and metastasis is poorly understood.	Flavonoids	17-27	hepatocyte growth factor	Homo sapiens	166-169
18063365-2	2008	In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2.	Flavonoids	17-26	cyclin dependent kinase 2	Homo sapiens	36-61
17961621-3	2008	In our preliminary study, we use HGF as an invasive inducer to investigate the effect of flavonoids including apigenin, naringenin, genistein and kaempferol on HGF-dependent invasive growth of MDA-MB-231 human breast cancer cells.	Flavonoids	89-99	hepatocyte growth factor	Homo sapiens	160-163
18063365-2	2008	In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2.	Flavonoids	17-26	cyclin dependent kinase 2	Homo sapiens	63-67
18063365-2	2008	In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2.	Flavonoids	17-26	cyclin dependent kinase 2	Homo sapiens	158-162
18086153-4	2008	In vitro testing of this list identified six flavonoids to have stimulated PPAR-gamma transcriptional activity in a transcriptional factor assay.	Flavonoids	45-55	peroxisome proliferator activated receptor gamma	Homo sapiens	75-85
19112469-5	2008	Moreover, the flavonoid decreased Hsp27, procaspase-3, MRP and PKB expression in neuroblastoma cells and in neurons.	Flavonoids	14-23	heat shock protein family B (small) member 1	Homo sapiens	34-39
19112469-5	2008	Moreover, the flavonoid decreased Hsp27, procaspase-3, MRP and PKB expression in neuroblastoma cells and in neurons.	Flavonoids	14-23	caspase 3	Homo sapiens	41-53
19112469-5	2008	Moreover, the flavonoid decreased Hsp27, procaspase-3, MRP and PKB expression in neuroblastoma cells and in neurons.	Flavonoids	14-23	ATP binding cassette subfamily C member 1	Homo sapiens	55-58
19112469-5	2008	Moreover, the flavonoid decreased Hsp27, procaspase-3, MRP and PKB expression in neuroblastoma cells and in neurons.	Flavonoids	14-23	AKT serine/threonine kinase 1	Homo sapiens	63-66
17549591-0	2008	The flavonoid rutin induces astrocyte and microglia activation and regulates TNF-alpha and NO release in primary glial cell cultures.	Flavonoids	4-13	tumor necrosis factor	Rattus norvegicus	77-86
18791269-4	2008	Here, we demonstrate that tyrosinase which is commonly overexpressed in melanoma activates the bioflavonoid quercetin (Qct) and promotes an ataxia telangiectasia mutated (ATM)-dependent DNA damage response.	Flavonoids	95-107	tyrosinase	Homo sapiens	26-36
18791269-4	2008	Here, we demonstrate that tyrosinase which is commonly overexpressed in melanoma activates the bioflavonoid quercetin (Qct) and promotes an ataxia telangiectasia mutated (ATM)-dependent DNA damage response.	Flavonoids	95-107	ATM serine/threonine kinase	Homo sapiens	171-174
18086153-5	2008	Of these, flavonoid-psi-baptigenin-was classed as the most potent PPAR-gamma agonist, possessing low micromolar affinity (EC(50) = 2.9 microM).	Flavonoids	10-19	peroxisome proliferator activated receptor gamma	Homo sapiens	66-76
18086153-9	2008	Overall, these results offer insight into various naturally derived flavonoids as leads/templates for development of novel PPAR-gamma ligands.	Flavonoids	68-78	peroxisome proliferator activated receptor gamma	Homo sapiens	123-133
18175982-0	2008	Prenylated flavonoids with PTP1B inhibitory activity from the root bark of Erythrina mildbraedii.	Flavonoids	11-21	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	27-32
18175982-4	2008	This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.	Flavonoids	68-78	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	129-134
19326773-13	2008	All bioflavonoids, i.e., quercetin, diosmin, methyl hesperidin, gossypin and chrysin, decreased the transport of nitrendipine, a P-gp substrate in the rat intestine.	Flavonoids	4-17	phosphoglycolate phosphatase	Rattus norvegicus	129-133
17963707-3	2008	Little detailed information is available on how flavonoids interact with myeloperoxidase, which is the predominant peroxidase present at sites of inflammation.	Flavonoids	48-58	myeloperoxidase	Homo sapiens	73-88
18296268-1	2008	Milky sap isolated from Chelidonium majus L. (Greater Celandine) serves as a rich source of various biologically active substances such as alkaloids, flavonoids and phenolic acids.	Flavonoids	150-160	SH2 domain containing 1A	Homo sapiens	6-9
17963707-5	2008	We investigated how the flavonoid myricitrin is oxidized by myeloperoxidase and how it affects the activities of this enzyme.	Flavonoids	24-33	myeloperoxidase	Homo sapiens	60-75
17963707-9	2008	When myeloperoxidase oxidized myricitrin and related flavonoids it became irreversibly inactivated.	Flavonoids	53-63	myeloperoxidase	Homo sapiens	5-20
18569079-2	2008	In this study the authors analyzed whether incubation of murine macrophages with various flavonoids that have agonist or antagonist activity for the AhR (beta-naphthoflavone, alpha-naphthoflavone, quercetin, luteolin) affect the uptake and survival of L. monocytogenes.	Flavonoids	89-99	aryl-hydrocarbon receptor	Mus musculus	149-152
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Flavonoids	49-59	tumor necrosis factor	Homo sapiens	119-146
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Flavonoids	49-59	tumor necrosis factor	Homo sapiens	148-157
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Flavonoids	49-59	interleukin 6	Homo sapiens	164-177
19325719-0	2008	Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	Flavonoids	8-18	TNF superfamily member 10	Homo sapiens	43-98
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Flavonoids	49-59	interleukin 6	Homo sapiens	179-183
19325719-0	2008	Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	Flavonoids	8-18	TNF superfamily member 10	Homo sapiens	100-105
19325719-2	2008	The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors.	Flavonoids	23-33	TNF superfamily member 10	Homo sapiens	39-44
19325719-4	2008	It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells.	Flavonoids	68-78	TNF superfamily member 10	Homo sapiens	109-114
19005980-0	2008	Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids.	Flavonoids	73-83	vascular endothelial growth factor A	Homo sapiens	30-34
18949064-0	2008	The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells.	Flavonoids	4-13	nuclear factor kappa B subunit 1	Homo sapiens	93-102
18949064-10	2008	CONCLUSIONS: The flavonoid, fisetin, could be useful in attenuation of UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells, which suggests that fisetin has a potential protective effect against cataractogenesis.	Flavonoids	17-26	nuclear factor kappa B subunit 1	Homo sapiens	131-140
18979154-0	2008	The flavonoid quercetin induces apoptosis and inhibits migration through a MAPK-dependent mechanism in osteoblasts.	Flavonoids	4-13	mitogen-activated protein kinase 1	Homo sapiens	75-79
19005980-6	2008	From both RT-qPCR and ELISA results, all flavonoids have shown varied degrees of inhibition in VEGF expression.	Flavonoids	41-51	vascular endothelial growth factor A	Homo sapiens	95-99
18850181-2	2007	It is likely that flavonoids exert such effects in neurons, through selective actions on different components within a number of protein kinase and lipid kinase signalling cascades, such as phosphatidylinositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase.	Flavonoids	18-28	AKT serine/threonine kinase 1	Homo sapiens	227-230
18346377-13	2008	CONCLUSION: Epimedium flavonoids could protect the synaptic structure and function by promoting the expression of synaptophysin and postsynaptic dense material 95, which suggest that Epimedium Flavonoids may have a promising application prospect in improving the synaptic impairment of AD.	Flavonoids	22-32	synaptophysin	Mus musculus	114-127
18346377-13	2008	CONCLUSION: Epimedium flavonoids could protect the synaptic structure and function by promoting the expression of synaptophysin and postsynaptic dense material 95, which suggest that Epimedium Flavonoids may have a promising application prospect in improving the synaptic impairment of AD.	Flavonoids	22-32	discs large MAGUK scaffold protein 4	Mus musculus	132-162
18346377-13	2008	CONCLUSION: Epimedium flavonoids could protect the synaptic structure and function by promoting the expression of synaptophysin and postsynaptic dense material 95, which suggest that Epimedium Flavonoids may have a promising application prospect in improving the synaptic impairment of AD.	Flavonoids	193-203	synaptophysin	Mus musculus	114-127
18346377-13	2008	CONCLUSION: Epimedium flavonoids could protect the synaptic structure and function by promoting the expression of synaptophysin and postsynaptic dense material 95, which suggest that Epimedium Flavonoids may have a promising application prospect in improving the synaptic impairment of AD.	Flavonoids	193-203	discs large MAGUK scaffold protein 4	Mus musculus	132-162
17482445-5	2008	The results suggested that flavonoids from E. koreanum Nakai may improve the development of osteoblasts by promoting the ALP activity; and icariin might be one of the active constituents facilitating the differentiation of osteoblasts.	Flavonoids	27-37	PDZ and LIM domain 3	Rattus norvegicus	121-124
17888554-4	2008	This study was undertaken to provide a behavioral characterization of two novels halogenated flavonoids, 5-methoxy-6, 8-dibromoflavanone (FV1), and 6-bromoflavanone (FV2).	Flavonoids	93-103	Friend virus susceptibility 1	Mus musculus	138-141
18386491-0	2008	Flavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomerase.	Flavonoids	0-10	DNA topoisomerase I	Homo sapiens	56-80
17551714-7	2007	In addition to these effects that may be attributed to their antioxidative potential kaempferol and fisetin caused a translocation of the C. elegans FoxO transcription factor DAF-16 from the cytosol to the nucleus indicating a modulatory influence of both flavonoids on signalling cascade(s).	Flavonoids	256-266	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	175-181
18850185-0	2007	Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid.	Flavonoids	119-128	signal transducer and activator of transcription 1	Homo sapiens	103-108
18225583-4	2007	RESULTS: Effective MRP1 inhibitors were identified among the stilbenes (piceatannol and its derivatives) and the flavonoids (aromadendrin, naringenin and its derivatives).	Flavonoids	113-123	ATP binding cassette subfamily C member 1	Homo sapiens	19-23
18089721-3	2007	After eliminating flavonoids and compounds of limited availability from the 18 original compounds, 10 of the 11 remaining compounds reversed mitoxantrone resistance in NCI-H460/MX20 cells and prevented ABCG2-mediated BODIPY-prazosin transport in ABCG2-transfected HEK293 cells, confirming an interaction with ABCG2.	Flavonoids	18-28	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	202-207
17999354-6	2007	The substance, acting in concert with honey flavonoids (COX-2 inhibitors), by antagonizing the NMDA receptor may contribute to the antinociceptive effect of honey.	Flavonoids	44-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
17937478-0	2007	Enzymatic acylation of flavonoids: effect of the nature of the substrate, origin of lipase, and operating conditions on conversion yield and regioselectivity.	Flavonoids	23-33	PAN0_003d1715	Moesziomyces antarcticus	84-90
17920288-0	2007	Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	31-41	solute carrier family 22 member 6	Homo sapiens	53-80
17920288-0	2007	Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	31-41	solute carrier family 22 member 6	Homo sapiens	82-87
17920288-0	2007	Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	31-41	solute carrier family 22 member 8	Homo sapiens	96-101
17920288-1	2007	The present study aimed to investigate the interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	74-84	solute carrier family 22 member 6	Homo sapiens	96-123
17920288-1	2007	The present study aimed to investigate the interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	74-84	solute carrier family 22 member 6	Homo sapiens	125-130
17920288-1	2007	The present study aimed to investigate the interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).	Flavonoids	74-84	solute carrier family 22 member 8	Homo sapiens	139-144
17920288-2	2007	Five flavonoids (morin, silybin, naringin, naringenin and quercetin) were selected and their interaction characteristics with hOAT1 and hOAT3 were examined in MDCK cells overexpressing hOAT1 or hOAT3.	Flavonoids	5-15	solute carrier family 22 member 6	Homo sapiens	126-131
17920288-2	2007	Five flavonoids (morin, silybin, naringin, naringenin and quercetin) were selected and their interaction characteristics with hOAT1 and hOAT3 were examined in MDCK cells overexpressing hOAT1 or hOAT3.	Flavonoids	5-15	solute carrier family 22 member 8	Homo sapiens	136-141
17920288-6	2007	In conclusion, the present study identified some of flavonoids as a new class of hOAT1 inhibitors, suggesting a potential for flavonoid-drug interactions via the modulation of hOAT1 activity.	Flavonoids	52-62	solute carrier family 22 member 6	Homo sapiens	81-86
17920288-6	2007	In conclusion, the present study identified some of flavonoids as a new class of hOAT1 inhibitors, suggesting a potential for flavonoid-drug interactions via the modulation of hOAT1 activity.	Flavonoids	52-62	solute carrier family 22 member 6	Homo sapiens	176-181
17920288-6	2007	In conclusion, the present study identified some of flavonoids as a new class of hOAT1 inhibitors, suggesting a potential for flavonoid-drug interactions via the modulation of hOAT1 activity.	Flavonoids	52-61	solute carrier family 22 member 6	Homo sapiens	81-86
17920288-6	2007	In conclusion, the present study identified some of flavonoids as a new class of hOAT1 inhibitors, suggesting a potential for flavonoid-drug interactions via the modulation of hOAT1 activity.	Flavonoids	52-61	solute carrier family 22 member 6	Homo sapiens	176-181
17927138-2	2007	This study aims to determine the contribution of UGT isoforms responsible for the metabolism of flavonoids in intact Caco-2 cells and cell lysates using siRNA.	Flavonoids	96-106	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	49-52
17643414-4	2007	In this study, the flavonoid compound flavone was demonstrated to significantly inhibit the enzyme activity of PARP-1.	Flavonoids	19-28	poly(ADP-ribose) polymerase 1	Homo sapiens	111-117
17345086-13	2007	CONCLUSION: Our present results thus indicate that many flavonoids selectively inhibit BCRP only.	Flavonoids	56-66	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	87-91
17953546-2	2007	As initially conceived in the early 1990s, it involved two main groups of molecules: nod gene-inducing flavonoids from plants and the mitogenic lipochito-oligosaccharide Nod factors of rhizobia.	Flavonoids	103-113	atrophin 1	Homo sapiens	85-88
17953546-5	2007	Expression of non-nod genes is induced by flavonoids; these include encoders of a type I secreted protein and the entire type III, and possibly also type IV, secretion systems.	Flavonoids	42-52	atrophin 1	Homo sapiens	18-21
17345086-0	2007	Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	19-51
17345086-2	2007	We previously reported that some flavonoids have BCRP-inhibitory activity.	Flavonoids	33-43	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	49-53
17345086-3	2007	Here we show the reversal effects of an extensive panel of flavonoids upon BCRP-, P-gp-, and MRP1-mediated drug resistance.	Flavonoids	59-69	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	75-79
17345086-3	2007	Here we show the reversal effects of an extensive panel of flavonoids upon BCRP-, P-gp-, and MRP1-mediated drug resistance.	Flavonoids	59-69	ATP binding cassette subfamily B member 1	Homo sapiens	82-86
17345086-3	2007	Here we show the reversal effects of an extensive panel of flavonoids upon BCRP-, P-gp-, and MRP1-mediated drug resistance.	Flavonoids	59-69	ATP binding cassette subfamily C member 1	Homo sapiens	93-97
17345086-4	2007	METHODS: Reversal effects of flavonoids upon BCRP-, P-gp-, or MRP1-mediated drug resistance were examined in the BCRP- or MDR1-transduced human leukemia K562 cells or in the MRP1-transfected human epidermoid carcinoma KB-3-1 cells using cell growth inhibition assays.	Flavonoids	29-39	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	45-49
17345086-4	2007	METHODS: Reversal effects of flavonoids upon BCRP-, P-gp-, or MRP1-mediated drug resistance were examined in the BCRP- or MDR1-transduced human leukemia K562 cells or in the MRP1-transfected human epidermoid carcinoma KB-3-1 cells using cell growth inhibition assays.	Flavonoids	29-39	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
17345086-4	2007	METHODS: Reversal effects of flavonoids upon BCRP-, P-gp-, or MRP1-mediated drug resistance were examined in the BCRP- or MDR1-transduced human leukemia K562 cells or in the MRP1-transfected human epidermoid carcinoma KB-3-1 cells using cell growth inhibition assays.	Flavonoids	29-39	ATP binding cassette subfamily C member 1	Homo sapiens	62-66
17345086-4	2007	METHODS: Reversal effects of flavonoids upon BCRP-, P-gp-, or MRP1-mediated drug resistance were examined in the BCRP- or MDR1-transduced human leukemia K562 cells or in the MRP1-transfected human epidermoid carcinoma KB-3-1 cells using cell growth inhibition assays.	Flavonoids	29-39	ATP binding cassette subfamily B member 1	Homo sapiens	122-126
17976262-0	2007	Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.	Flavonoids	21-31	solute carrier family 16 member 1	Homo sapiens	35-64
17976262-0	2007	Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.	Flavonoids	21-31	solute carrier family 16 member 1	Homo sapiens	66-70
17976262-1	2007	This study aimed to investigate the inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.	Flavonoids	57-67	solute carrier family 16 member 1	Homo sapiens	71-100
17976262-1	2007	This study aimed to investigate the inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.	Flavonoids	57-67	solute carrier family 16 member 1	Homo sapiens	102-106
17976262-6	2007	The effect of flavonoids on the gene expression of MCT1 was also examined by using RT-PCR and western blot analysis.	Flavonoids	14-24	solute carrier family 16 member 1	Homo sapiens	51-55
17976262-9	2007	In conclusion, some flavonoids appeared to be competitive inhibitors of MCT1, suggesting the potential for diet-drug interactions between flavonoids and MCT1 substrates.	Flavonoids	20-30	solute carrier family 16 member 1	Homo sapiens	72-76
17976262-9	2007	In conclusion, some flavonoids appeared to be competitive inhibitors of MCT1, suggesting the potential for diet-drug interactions between flavonoids and MCT1 substrates.	Flavonoids	20-30	solute carrier family 16 member 1	Homo sapiens	153-157
17976262-9	2007	In conclusion, some flavonoids appeared to be competitive inhibitors of MCT1, suggesting the potential for diet-drug interactions between flavonoids and MCT1 substrates.	Flavonoids	138-148	solute carrier family 16 member 1	Homo sapiens	72-76
18052087-0	2007	Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.	Flavonoids	15-25	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	147-150
28903234-3	2007	The data obtained demonstrate thenecessity of taking into account not only ability of flavonoids to bind to Ah receptor(induction factor) but also to concentrate on their distribution and metabolism (includingcolon microflora) in the body.	Flavonoids	86-96	aryl hydrocarbon receptor	Homo sapiens	108-136
17950758-3	2007	Considering the report that dioxin, an aryl hydrocarbon receptor (AhR) agonist, disrupts the transcriptional activity of ER without binding to the ER, 14 flavonoids were examined for the transcriptional activity of AhR by the yeast reporter assay (AhR).	Flavonoids	154-164	aryl hydrocarbon receptor	Homo sapiens	215-218
17950758-3	2007	Considering the report that dioxin, an aryl hydrocarbon receptor (AhR) agonist, disrupts the transcriptional activity of ER without binding to the ER, 14 flavonoids were examined for the transcriptional activity of AhR by the yeast reporter assay (AhR).	Flavonoids	154-164	aryl hydrocarbon receptor	Homo sapiens	215-218
17950758-7	2007	Thus, FLA inhibited the estrogen action without binding to the ER by acting as a competitive agonist for AhR, which meaning that there can be anti-estrogenic flavonoids such as FLA as well as estrogenic ones such as isoflavones.	Flavonoids	158-168	aryl hydrocarbon receptor	Homo sapiens	105-108
18173118-2	2007	Anode peak voltages (Eap) and their pH dependences were determined for the studied phenolic acids and flavonoids.	Flavonoids	102-112	glutamyl aminopeptidase	Homo sapiens	21-24
17637507-0	2007	Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.	Flavonoids	40-49	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	68-73
17320090-8	2007	Compared to placebo (ANOVA and Tukey"s test), flavonoids significantly reduced serum 8-isoprostans (p&lt;0.000) and Ox-LDL levels (p&lt;0.000) (by 38 and 29%, respectively), as well as hsCRP (p&lt;0.007) and MCP-1 (p&lt;0.001) levels (by 23 and 29%, respectively).	Flavonoids	46-56	C-C motif chemokine ligand 2	Homo sapiens	208-213
17637507-4	2007	We have used a set of 15 flavonoid inhibitors of the PIM-1 kinase, aligned de novo by common substructure, to generate a CoMFA model for the purpose of elucidating the steric and electrostatic properties involved in flavonoid binding to the PIM-1 kinase.	Flavonoids	25-34	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	53-58
17637507-4	2007	We have used a set of 15 flavonoid inhibitors of the PIM-1 kinase, aligned de novo by common substructure, to generate a CoMFA model for the purpose of elucidating the steric and electrostatic properties involved in flavonoid binding to the PIM-1 kinase.	Flavonoids	216-225	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	53-58
17637507-4	2007	We have used a set of 15 flavonoid inhibitors of the PIM-1 kinase, aligned de novo by common substructure, to generate a CoMFA model for the purpose of elucidating the steric and electrostatic properties involved in flavonoid binding to the PIM-1 kinase.	Flavonoids	216-225	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	241-246
17583542-3	2007	We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase.	Flavonoids	40-49	catalase	Homo sapiens	284-292
17583542-3	2007	We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase.	Flavonoids	40-49	glutathione S-transferase kappa 1	Homo sapiens	297-322
17583542-3	2007	We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase.	Flavonoids	176-185	catalase	Homo sapiens	284-292
17583542-3	2007	We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase.	Flavonoids	176-185	glutathione S-transferase kappa 1	Homo sapiens	297-322
17884996-3	2007	In this study, the in vitro PARP-1-inhibiting effect of various flavonoids was investigated.	Flavonoids	64-74	poly(ADP-ribose) polymerase 1	Homo sapiens	28-34
17880176-2	2007	In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins).	Flavonoids	364-377	catechol-O-methyltransferase	Homo sapiens	88-92
17917302-0	2007	Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana.	Flavonoids	27-37	nerve growth factor	Rattus norvegicus	43-46
17884996-6	2007	Finally, IL-8 production of LPS-stimulated human pulmonary epithelial cells could be significantly reduced by these flavonoids.	Flavonoids	116-126	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
17884996-7	2007	The results of this study indicate that specific flavonoids have PARP-1-inhibiting activity in addition to the earlier described antioxidant effects.	Flavonoids	49-59	poly(ADP-ribose) polymerase 1	Homo sapiens	65-71
17884996-8	2007	PARP-1 inhibition and preservation of cellular NAD(+) and energy production could play a role in the antiinflammatory activity of these specific flavonoids.	Flavonoids	145-155	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
17629694-2	2007	Judging from the data for the inhibition of NADPH- and NADH-dependent 20alpha-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20alpha-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-HSD activities.	Flavonoids	96-106	aldo-keto reductase family 1, member C18	Mus musculus	70-81
17624765-1	2007	Previous studies have shown chrysin, 7-hydroxyflavone and 7,4"-dihydroxyflavone to be the most potent flavonoid inhibitors of aromatase.	Flavonoids	102-111	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	126-135
17629694-2	2007	Judging from the data for the inhibition of NADPH- and NADH-dependent 20alpha-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20alpha-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-HSD activities.	Flavonoids	96-106	aldo-keto reductase family 1, member C18	Mus musculus	161-172
17629694-1	2007	The effects of flavonoids and quinones on NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) activities were examined in cytosolic fractions from the liver and kidney of mice.	Flavonoids	15-25	aldo-keto reductase family 1, member C18	Mus musculus	68-104
17629694-2	2007	Judging from the data for the inhibition of NADPH- and NADH-dependent 20alpha-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20alpha-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-HSD activities.	Flavonoids	96-106	aldo-keto reductase family 1, member C18	Mus musculus	161-172
17629694-1	2007	The effects of flavonoids and quinones on NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) activities were examined in cytosolic fractions from the liver and kidney of mice.	Flavonoids	15-25	aldo-keto reductase family 1, member C18	Mus musculus	106-117
17594112-0	2007	Both caffeoyl Coenzyme A 3-O-methyltransferase 1 and caffeic acid O-methyltransferase 1 are involved in redundant functions for lignin, flavonoids and sinapoyl malate biosynthesis in Arabidopsis.	Flavonoids	136-146	O-methyltransferase 1	Arabidopsis thaliana	53-85
17604372-2	2007	The results showed that the flavonoid fraction of D. gangeticum possesses potent antioxidant activity compared with the alkaloid fraction and also with respect to the standard drug indomethacin, in terms of augmentation of the liver and spleen SOD, CAT and GPX activities, concomitant with a reduction in lipid peroxidation (TBARS).	Flavonoids	28-37	catalase	Rattus norvegicus	249-252
17785825-6	2007	We found that in hemopoietic cells from human and mouse origin, some flavonoids were able to inhibit the activation of STAT6 by IL-4.	Flavonoids	69-79	signal transducer and activator of transcription 6	Mus musculus	119-124
17886198-0	2007	Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids.	Flavonoids	88-98	matrix metallopeptidase 1	Homo sapiens	37-63
17886198-5	2007	By means of the electrophoretic mobility shift assay, these flavonoids were also found to inhibit activation of the transcription factor, activator protein-1 (AP-1).	Flavonoids	60-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-157
17886198-5	2007	By means of the electrophoretic mobility shift assay, these flavonoids were also found to inhibit activation of the transcription factor, activator protein-1 (AP-1).	Flavonoids	60-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-163
17886198-8	2007	These results have shown, for the first time, that naturally-occurring flavonoids (quercetin, kaempferol, apigenin and wogonin) inhibit MMP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.	Flavonoids	71-81	matrix metallopeptidase 1	Homo sapiens	136-141
17886198-8	2007	These results have shown, for the first time, that naturally-occurring flavonoids (quercetin, kaempferol, apigenin and wogonin) inhibit MMP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.	Flavonoids	71-81	matrix metallopeptidase 1	Homo sapiens	160-165
17886198-8	2007	These results have shown, for the first time, that naturally-occurring flavonoids (quercetin, kaempferol, apigenin and wogonin) inhibit MMP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.	Flavonoids	71-81	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-206
17785825-6	2007	We found that in hemopoietic cells from human and mouse origin, some flavonoids were able to inhibit the activation of STAT6 by IL-4.	Flavonoids	69-79	interleukin 4	Mus musculus	128-132
17458902-10	2007	The structure-related inhibition of E2/IGF-I-induced proliferative events by flavonoids is elucidated.	Flavonoids	77-87	cystatin 12, pseudogene	Homo sapiens	36-44
17572073-0	2007	Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.	Flavonoids	0-10	dehydrogenase/reductase 4	Rattus norvegicus	124-142
17572073-3	2007	Flavonoids represent a potentially attractive class of compounds to mitigate the anthracycline cardiotoxicity due to their iron-chelating, antioxidant and carbonyl reductase-inhibitory effects.	Flavonoids	0-10	dehydrogenase/reductase 4	Rattus norvegicus	155-173
17630199-5	2007	Herein we characterize the effect of the flavonoids quercetin, genistein, luteolin, and quercetagetin on LPS-activated transduction mechanism regulation in human gingival fibroblasts (HGF).	Flavonoids	41-51	hepatocyte growth factor	Homo sapiens	184-187
17630199-6	2007	In this study, we investigated the role of the previously mentioned flavonoids on mitogen-activated protein kinase (MAPK) activation induced by LPS obtained from P. gingivalis.	Flavonoids	68-78	mitogen-activated protein kinase 3	Homo sapiens	116-120
17630199-8	2007	All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1beta, and cyclooxygenase-2 (COX-2) expression, IL-1beta and prostaglandin E2 (PGE2) synthesis.	Flavonoids	4-14	mitogen-activated protein kinase 3	Homo sapiens	52-56
17630199-8	2007	All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1beta, and cyclooxygenase-2 (COX-2) expression, IL-1beta and prostaglandin E2 (PGE2) synthesis.	Flavonoids	4-14	interleukin 1 beta	Homo sapiens	69-87
17630199-8	2007	All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1beta, and cyclooxygenase-2 (COX-2) expression, IL-1beta and prostaglandin E2 (PGE2) synthesis.	Flavonoids	4-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-109
17630199-8	2007	All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1beta, and cyclooxygenase-2 (COX-2) expression, IL-1beta and prostaglandin E2 (PGE2) synthesis.	Flavonoids	4-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116
17630199-8	2007	All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1beta, and cyclooxygenase-2 (COX-2) expression, IL-1beta and prostaglandin E2 (PGE2) synthesis.	Flavonoids	4-14	interleukin 1 beta	Homo sapiens	130-138
17876056-4	2007	In this study, we have investigated whether the flavonoid quercetin could sensitize human colon adenocarcinoma cell lines to TRAIL-induced apoptosis.	Flavonoids	48-57	TNF superfamily member 10	Homo sapiens	125-130
17887937-6	2007	These results suggest that this natural, flavonoid mixture acts via "dual inhibition" of COX and LOX enzymes to reduce production of pro-inflammatory eicosanoids and attenuate edema in an in vivo model of inflammation.	Flavonoids	41-50	linoleate 9S-lipoxygenase 2	Solanum tuberosum	97-100
17666819-8	2007	It seems to be likely that these flavonoids reduce serum urate levels by mainly inhibiting XOD activity.	Flavonoids	33-43	xanthine dehydrogenase	Mus musculus	91-94
17560542-0	2007	Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids.	Flavonoids	71-81	aryl hydrocarbon receptor	Homo sapiens	24-49
17560542-1	2007	Flavonoids have been reported to be dietary antagonists of an aryl hydrocarbon receptor (AhR).	Flavonoids	0-10	aryl hydrocarbon receptor	Homo sapiens	62-87
17560542-1	2007	Flavonoids have been reported to be dietary antagonists of an aryl hydrocarbon receptor (AhR).	Flavonoids	0-10	aryl hydrocarbon receptor	Homo sapiens	89-92
17560542-3	2007	In this study, the inhibitory effect of flavonoids on ligand binding to the AhR and interaction between flavonoids and the AhR complex (AhRc) were investigated in each flavonoid subclass.	Flavonoids	40-50	aryl hydrocarbon receptor	Homo sapiens	76-79
17560542-3	2007	In this study, the inhibitory effect of flavonoids on ligand binding to the AhR and interaction between flavonoids and the AhR complex (AhRc) were investigated in each flavonoid subclass.	Flavonoids	104-114	aryl hydrocarbon receptor	Homo sapiens	123-126
17560542-3	2007	In this study, the inhibitory effect of flavonoids on ligand binding to the AhR and interaction between flavonoids and the AhR complex (AhRc) were investigated in each flavonoid subclass.	Flavonoids	40-49	aryl hydrocarbon receptor	Homo sapiens	76-79
17847709-4	2007	Tyrosinase inhibition by the flavonoid mixture and galangin were higher at lower concentrations and galangin showed competitive inhibition at a concentration less than 21.23 microg/mL which was soluble.	Flavonoids	29-38	tyrosinase	Mus musculus	0-10
17468513-0	2007	Dietary flavonoids induce MLL translocations in primary human CD34+ cells.	Flavonoids	8-18	lysine methyltransferase 2A	Homo sapiens	26-29
17468513-0	2007	Dietary flavonoids induce MLL translocations in primary human CD34+ cells.	Flavonoids	8-18	CD34 molecule	Homo sapiens	62-66
17468513-3	2007	Since flavonoids are potent topoII inhibitors, we examined the role of three widely consumed dietary flavonoids (quercetin, genistein and kaempferol) on the development of MLL rearrangements in primary human CD34(+) cells.	Flavonoids	101-111	lysine methyltransferase 2A	Homo sapiens	172-175
17685873-1	2007	NV-52, a synthetic flavonoid derivative, is a selective thromboxane synthase (TXS) inhibitor that is being developed as a treatment for inflammatory bowel disease.	Flavonoids	19-28	thromboxane A synthase 1, platelet	Mus musculus	56-76
17685873-1	2007	NV-52, a synthetic flavonoid derivative, is a selective thromboxane synthase (TXS) inhibitor that is being developed as a treatment for inflammatory bowel disease.	Flavonoids	19-28	thromboxane A synthase 1, platelet	Mus musculus	78-81
17701137-0	2007	Mechanism of inhibition of human secretory phospholipase A2 by flavonoids: rationale for lead design.	Flavonoids	63-73	phospholipase A2 group IB	Homo sapiens	43-59
17701137-5	2007	However, the mechanism by which flavonoids inhibit Phospholipase A2 (PLA2) remained unclear so far.	Flavonoids	32-42	phospholipase A2 group IB	Homo sapiens	51-67
17701137-5	2007	However, the mechanism by which flavonoids inhibit Phospholipase A2 (PLA2) remained unclear so far.	Flavonoids	32-42	phospholipase A2 group IB	Homo sapiens	69-73
17701137-7	2007	Our work focuses on understanding the binding modes of flavonoids to PLA2, their inhibition mechanism and the rationale to modify them to obtain potent and specific inhibitors.	Flavonoids	55-65	phospholipase A2 group IB	Homo sapiens	69-73
17701137-13	2007	Based on our results, we suggest C(6) as the most promising position of the flavonoid scaffold to introduce chemical modifications to improve affinity, selectivity, and inhibition of PLA2-IIA by flavonoids.	Flavonoids	76-85	phospholipase A2 group IB	Homo sapiens	183-187
17701137-13	2007	Based on our results, we suggest C(6) as the most promising position of the flavonoid scaffold to introduce chemical modifications to improve affinity, selectivity, and inhibition of PLA2-IIA by flavonoids.	Flavonoids	195-205	phospholipase A2 group IB	Homo sapiens	183-187
17425630-7	2007	The binding of flavonoids to TP in platelets, human myometrium and TPalpha- and TPbeta-transfected HEK 293T cells was explored using binding assays and the TP antagonist (3)H-SQ29548.	Flavonoids	15-25	thymopoietin	Homo sapiens	67-86
17425630-9	2007	These flavonoids caused a significant impairment of U46619-induced platelet tyrosine phosphorylation and of ERK 1/2 activation.	Flavonoids	6-16	mitogen-activated protein kinase 3	Homo sapiens	108-115
17425630-10	2007	By contrast, in aspirin-treated platelets all these flavonoids, except quercetin, displayed minor effects on thrombin-induced calcium mobilization, ERK 1/2 and total tyrosine phosphorylation.	Flavonoids	52-62	mitogen-activated protein kinase 3	Homo sapiens	148-155
17466980-0	2007	Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine.	Flavonoids	182-192	LPMP_282420	Leishmania panamensis	57-77
17847711-5	2007	Flavonoids such as quercetin, fisetin and kaempferol exhibited high inhibitory potencies for 20alpha-HSD activity in liver cytosol, whereas these flavonoids were poor inhibitors for the enzyme activity in kidney cytosol.	Flavonoids	0-10	aldo-keto reductase family 1, member C18	Mus musculus	93-104
17847711-6	2007	It is likely that several diesel exhaust components and flavonoids augment the signaling of progesterone in the liver cells, by potently inhibiting 20alpha-HSD activity in mouse liver cytosol.	Flavonoids	56-66	aldo-keto reductase family 1, member C18	Mus musculus	148-159
17847711-0	2007	Inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.	Flavonoids	52-62	aldo-keto reductase family 1, member C18	Mus musculus	66-102
17847711-1	2007	The inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) activity were examined in cytosolic fractions from the liver, kidney and lung of male mice.	Flavonoids	56-66	aldo-keto reductase family 1, member C18	Mus musculus	70-106
17847711-1	2007	The inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) activity were examined in cytosolic fractions from the liver, kidney and lung of male mice.	Flavonoids	56-66	aldo-keto reductase family 1, member C18	Mus musculus	108-119
17495124-1	2007	There is controversy as to whether intestinal absorption of glycosylated flavonoids, and particularly quercetin glycosides, involves their uptake in intact form via the human sodium-coupled glucose transporter hSGLT1.	Flavonoids	73-83	solute carrier family 5 member 1	Homo sapiens	210-216
17495124-10	2007	However, not only glycosylated but also a few nonglycosylated flavonoids show a structure-dependent capability for effective inhibition of SGLT1.	Flavonoids	62-72	solute carrier family 5 member 1	Homo sapiens	139-144
17867560-0	2007	Studies on the flavonoid substrates of human UDP-glucuronosyl transferase (UGT) 2B7.	Flavonoids	15-24	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	45-83
17867560-3	2007	This study suggests features of the flavonoid structure necessary for it to act as a substrate of human UGT2B7.	Flavonoids	36-45	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	104-110
17867560-7	2007	Increasing the number of hydroxyl groups of flavonoids will increase their glucuronidation activity towards UGT2B7, while conjugation of glycon will weaken the activity, and hydroxyl position can also have an important role in activity.	Flavonoids	44-54	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	108-114
17867560-8	2007	The high glucuronidation efficiency observed with many flavonoids suggests that the contribution of UGT2B7 to the metabolism of flavonoids may be significant.	Flavonoids	55-65	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	100-106
17867560-8	2007	The high glucuronidation efficiency observed with many flavonoids suggests that the contribution of UGT2B7 to the metabolism of flavonoids may be significant.	Flavonoids	128-138	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	100-106
17638904-0	2007	Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice.	Flavonoids	44-53	catenin (cadherin associated protein), beta 1	Mus musculus	12-24
17509533-1	2007	The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles.	Flavonoids	124-133	ATP binding cassette subfamily C member 1	Homo sapiens	177-181
17509533-1	2007	The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles.	Flavonoids	124-133	ATP binding cassette subfamily C member 2	Homo sapiens	186-190
17509533-6	2007	This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance.	Flavonoids	110-120	ATP binding cassette subfamily C member 1	Homo sapiens	160-163
17603933-0	2007	Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin.	Flavonoids	55-64	albumin	Homo sapiens	107-120
17603933-1	2007	This work provides a quantitative kinetic analysis of oxidative pathways involving linoleic acid and the common dietary antioxidant quercetin (flavonoid), both bound to human serum albumin (HSA).	Flavonoids	143-152	albumin	Homo sapiens	175-188
17552510-0	2007	Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.	Flavonoids	26-35	BCL2 apoptosis regulator	Homo sapiens	112-117
17552510-1	2007	Structure-based strategy was employed to design flavonoid compounds to mimic the Bim BH3 peptide as a new class of inhibitors of the anti-apoptotic Bcl-2 proteins.	Flavonoids	48-57	BCL2 apoptosis regulator	Homo sapiens	148-153
17611628-0	2007	The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.	Flavonoids	4-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-68
17611628-0	2007	The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.	Flavonoids	4-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-120
17356895-0	2007	Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G.	Flavonoids	57-67	tumor protein p53	Homo sapiens	81-84
17356895-0	2007	Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G.	Flavonoids	57-67	endonuclease G	Homo sapiens	152-166
17616737-4	2007	Furthermore, MYC2 positively regulates JA-mediated resistance to insect pests, such as Helicoverpa armigera, and tolerance to oxidative stress, possibly via enhanced ascorbate redox cycling and flavonoid biosynthesis.	Flavonoids	194-203	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	13-17
17452418-6	2007	In Caco-2 cells, demonstrated to contain minimal CYP3A activity, the permeability coefficient of the prodrugs lovastatin and enalapril was increased in the presence of the active flavonoids kaempferol and naringenin, consistent with inhibition of esterase activity.	Flavonoids	179-189	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-54
17620442-2	2007	In this study, we showed that luteolin, a naturally occurring flavonoid, is a potent stimulator of HER2 degradation.	Flavonoids	62-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	99-103
17478633-0	2007	RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits.	Flavonoids	71-80	chalcone synthase 1	Solanum lycopersicum	30-47
17478633-3	2007	In this article, we propose a novel strategy to obtain parthenocarpic tomatoes by down-regulation of the flavonoid biosynthesis pathway using RNA interference (RNAi)-mediated suppression of chalcone synthase (CHS), the first gene in the flavonoid pathway.	Flavonoids	105-114	chalcone synthase 1	Solanum lycopersicum	190-207
17478633-3	2007	In this article, we propose a novel strategy to obtain parthenocarpic tomatoes by down-regulation of the flavonoid biosynthesis pathway using RNA interference (RNAi)-mediated suppression of chalcone synthase (CHS), the first gene in the flavonoid pathway.	Flavonoids	105-114	chalcone synthase 1	Solanum lycopersicum	209-212
17478633-3	2007	In this article, we propose a novel strategy to obtain parthenocarpic tomatoes by down-regulation of the flavonoid biosynthesis pathway using RNA interference (RNAi)-mediated suppression of chalcone synthase (CHS), the first gene in the flavonoid pathway.	Flavonoids	237-246	chalcone synthase 1	Solanum lycopersicum	190-207
17478633-3	2007	In this article, we propose a novel strategy to obtain parthenocarpic tomatoes by down-regulation of the flavonoid biosynthesis pathway using RNA interference (RNAi)-mediated suppression of chalcone synthase (CHS), the first gene in the flavonoid pathway.	Flavonoids	237-246	chalcone synthase 1	Solanum lycopersicum	209-212
17478633-4	2007	In CHS RNAi plants, total flavonoid levels, transcript levels of both Chs1 and Chs2, as well as CHS enzyme activity were reduced by up to a few percent of the corresponding wild-type values.	Flavonoids	26-35	chalcone synthase 1	Solanum lycopersicum	3-6
17384531-7	2007	The inhibitory activity of flavonoids on IL-4 and CD40 ligand expression was possibly mediated through their inhibitory action on activation of nuclear factors of activated T cells and AP-1.	Flavonoids	27-37	CD40 antigen	Mus musculus	50-54
17482578-1	2007	Five flavonoid structural genes, encoding chalcone isomerase, flavanone 3-hydroxylase, dihydroflavonol 4-reductase, anthocyanidin synthase, and anthocyanidin reductase, were cloned from a brown-fiber cotton line (T586).	Flavonoids	5-14	leucoanthocyanidin dioxygenase-like	Gossypium hirsutum	116-167
17499637-0	2007	Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection.	Flavonoids	86-96	interleukin 1 beta	Homo sapiens	14-31
17499637-3	2007	Flavonoids significantly decreased the release of reactive oxygen species (ROS) from astrocytes stimulated with IL-1beta.	Flavonoids	0-10	interleukin 1 beta	Homo sapiens	112-120
17499637-6	2007	Significant decrease in neuronal apoptosis was observed in neurons cultured in conditioned medium obtained from astrocytes treated with a combination of IL-1beta and flavonoids as compared to that treated with IL-1beta alone.	Flavonoids	166-176	interleukin 1 beta	Homo sapiens	210-218
17408892-0	2007	Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression.	Flavonoids	0-10	interferon gamma	Homo sapiens	71-80
17384531-5	2007	Flavonoids inhibit histamine release, synthesis of IL-4 and IL-13 and CD40 ligand expression by basophils.	Flavonoids	0-10	interleukin 4	Mus musculus	51-55
17601828-0	2007	The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat.	Flavonoids	57-66	MATE efflux family protein	Arabidopsis thaliana	33-37
17384531-5	2007	Flavonoids inhibit histamine release, synthesis of IL-4 and IL-13 and CD40 ligand expression by basophils.	Flavonoids	0-10	interleukin 13	Mus musculus	60-65
17384531-5	2007	Flavonoids inhibit histamine release, synthesis of IL-4 and IL-13 and CD40 ligand expression by basophils.	Flavonoids	0-10	CD40 antigen	Mus musculus	70-74
17384531-7	2007	The inhibitory activity of flavonoids on IL-4 and CD40 ligand expression was possibly mediated through their inhibitory action on activation of nuclear factors of activated T cells and AP-1.	Flavonoids	27-37	interleukin 4	Mus musculus	41-45
17638535-5	2007	An inverse relationship was observed between the number of hydroxyl groups in flavonoids and ERalpha bioactivity.	Flavonoids	78-88	estrogen receptor 1	Homo sapiens	93-100
17638535-8	2007	Our assay reveals superagonistic, additive, and antagonistic ERalpha or ERbeta actions of flavonoids and adds to our understanding of the estrogenic effects of phytoestrogens in complex mixtures.	Flavonoids	90-100	estrogen receptor 1	Homo sapiens	61-68
17638535-8	2007	Our assay reveals superagonistic, additive, and antagonistic ERalpha or ERbeta actions of flavonoids and adds to our understanding of the estrogenic effects of phytoestrogens in complex mixtures.	Flavonoids	90-100	estrogen receptor 2	Homo sapiens	72-78
17637178-5	2007	Previous observations in our laboratory demonstrated that methoxylated flavonoids may be effective inhibitors of CYP1A1 transcription and activity as well as being orally bioavailable.	Flavonoids	71-81	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
17219438-2	2007	The six flavonoids suppressed the EGF-induced activation of activator protein 1 (AP-1).	Flavonoids	8-18	jun proto-oncogene	Mus musculus	60-79
17219438-2	2007	The six flavonoids suppressed the EGF-induced activation of activator protein 1 (AP-1).	Flavonoids	8-18	jun proto-oncogene	Mus musculus	81-85
17541165-0	2007	Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents.	Flavonoids	111-120	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	61-67
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Flavonoids	94-103	carbonyl reductase 1	Homo sapiens	37-41
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Flavonoids	94-103	carbonyl reductase 1	Homo sapiens	50-54
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Flavonoids	94-103	carbonyl reductase 1	Homo sapiens	50-54
17344335-9	2007	Inhibition studies demonstrated that CBR1 V88 and CBR1 I88 are distinctively inhibited by the flavonoid, rutin (IC50 CBR1 V88, 54.0 +/- 0.4 microM versus IC50 CBR1 I88, 15.0 +/- 0.1 microM, p &lt; 0.001).	Flavonoids	94-103	carbonyl reductase 1	Homo sapiens	50-54
17377063-8	2007	Two iron-chelating moieties in quercetin, -OH at position 3 of the C ring and/or -OH at positions 3" and 4" of the B ring, enabled the flavonoid to inhibit HPH and subsequently induce HIF-1alpha.	Flavonoids	135-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	184-194
17614721-1	2007	Human serum albumin (HSA) complexation with quercetin, a flavonoid commonly present in human diet, was monitored by means of fluorescence decays of the single HSA tryptophan - Trp214.	Flavonoids	57-66	albumin	Homo sapiens	6-19
17395203-1	2007	The nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzyme dihydroflavonol 4-reductase (DFR) catalyzes a late step in the biosynthesis of anthocyanins and condensed tannins, two flavonoid classes of importance to plant survival and human nutrition.	Flavonoids	192-201	dihydroflavonol 4-reductase	Vitis vinifera	102-105
17324381-1	2007	Both natural and synthetic flavonoids are known to interact with the aryl hydrocarbon receptor (AhR); however, their agonist/antagonist properties in vitro have been so far studied mostly in the context of cytochrome P450 1A1 gene (Cyp1a1) regulation.	Flavonoids	27-37	aryl hydrocarbon receptor	Rattus norvegicus	69-94
17324381-1	2007	Both natural and synthetic flavonoids are known to interact with the aryl hydrocarbon receptor (AhR); however, their agonist/antagonist properties in vitro have been so far studied mostly in the context of cytochrome P450 1A1 gene (Cyp1a1) regulation.	Flavonoids	27-37	aryl hydrocarbon receptor	Rattus norvegicus	96-99
17324381-1	2007	Both natural and synthetic flavonoids are known to interact with the aryl hydrocarbon receptor (AhR); however, their agonist/antagonist properties in vitro have been so far studied mostly in the context of cytochrome P450 1A1 gene (Cyp1a1) regulation.	Flavonoids	27-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	206-225
17324381-1	2007	Both natural and synthetic flavonoids are known to interact with the aryl hydrocarbon receptor (AhR); however, their agonist/antagonist properties in vitro have been so far studied mostly in the context of cytochrome P450 1A1 gene (Cyp1a1) regulation.	Flavonoids	27-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	232-238
17266043-8	2007	We also showed that IL-6-induced AKR1C1/1C2 expression and drug resistance were inhibited by wogonin and chrysin, which are major flavonoids in Scutellaria baicalensis, a widely used traditional Chinese and Japanese medicine.	Flavonoids	130-140	interleukin 6	Homo sapiens	20-24
17266043-8	2007	We also showed that IL-6-induced AKR1C1/1C2 expression and drug resistance were inhibited by wogonin and chrysin, which are major flavonoids in Scutellaria baicalensis, a widely used traditional Chinese and Japanese medicine.	Flavonoids	130-140	aldo-keto reductase family 1 member C1	Homo sapiens	33-39
17612370-10	2007	Increased antioxidant defenses through activation of the NF-E2 related factor 2 (Nrf2) also contribute to the anti-inflammatory capacity of flavonoids.	Flavonoids	140-150	NFE2 like bZIP transcription factor 2	Homo sapiens	57-79
17612370-10	2007	Increased antioxidant defenses through activation of the NF-E2 related factor 2 (Nrf2) also contribute to the anti-inflammatory capacity of flavonoids.	Flavonoids	140-150	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
17419845-3	2007	MYB11, MYB12 and MYB111 show a high degree of functional similarity and display very similar target gene specificity for several genes of flavonoid biosynthesis, including CHALCONE SYNTHASE, CHALCONE ISOMERASE, FLAVANONE 3-HYDROXYLASE and FLAVONOL SYNTHASE1.	Flavonoids	138-147	myb domain protein 11	Arabidopsis thaliana	0-5
17419845-3	2007	MYB11, MYB12 and MYB111 show a high degree of functional similarity and display very similar target gene specificity for several genes of flavonoid biosynthesis, including CHALCONE SYNTHASE, CHALCONE ISOMERASE, FLAVANONE 3-HYDROXYLASE and FLAVONOL SYNTHASE1.	Flavonoids	138-147	myb domain protein 12	Arabidopsis thaliana	7-12
17085029-0	2007	Down-regulation of prostate specific antigen in LNCaP cells by flavonoids from the pollen of Brassica napus L. The pollen of Brassica napus L. has been used in China to treat benign prostatic hyperplasia (BPH) for over decades.	Flavonoids	63-73	kallikrein related peptidase 3	Homo sapiens	19-44
17419845-3	2007	MYB11, MYB12 and MYB111 show a high degree of functional similarity and display very similar target gene specificity for several genes of flavonoid biosynthesis, including CHALCONE SYNTHASE, CHALCONE ISOMERASE, FLAVANONE 3-HYDROXYLASE and FLAVONOL SYNTHASE1.	Flavonoids	138-147	myb domain protein 111	Arabidopsis thaliana	17-23
17419845-3	2007	MYB11, MYB12 and MYB111 show a high degree of functional similarity and display very similar target gene specificity for several genes of flavonoid biosynthesis, including CHALCONE SYNTHASE, CHALCONE ISOMERASE, FLAVANONE 3-HYDROXYLASE and FLAVONOL SYNTHASE1.	Flavonoids	138-147	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	172-189
17419845-3	2007	MYB11, MYB12 and MYB111 show a high degree of functional similarity and display very similar target gene specificity for several genes of flavonoid biosynthesis, including CHALCONE SYNTHASE, CHALCONE ISOMERASE, FLAVANONE 3-HYDROXYLASE and FLAVONOL SYNTHASE1.	Flavonoids	138-147	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	191-209
17292331-2	2007	As it has been demonstrated that polyphenolic compounds could modulate the expression level of the paraoxonase-1 gene in vitro, we have investigated the possible effect of flavonoid supplementation on the impaired paraoxonase-1 gene expression and activity induced by hyperhomocysteinemia and have evaluated the link with homocysteine metabolism.	Flavonoids	172-181	paraoxonase 1	Mus musculus	214-227
17429827-6	2007	In addition, these polymeric flavonoids efficiently inhibit disease related enzymes, such as xanthine oxidase, collagenase, elastase, hyaluronidase and tyrosinase.	Flavonoids	29-39	tyrosinase	Homo sapiens	152-162
17053893-4	2007	The examination of transcript levels showed that the general flavonoid pathway regulators PAP1 and PAP2 were up-regulated in response to nitrogen deficiency in wild type as well as pap1D plants.	Flavonoids	61-70	phosphatidic acid phosphatase 1	Arabidopsis thaliana	90-94
17053893-4	2007	The examination of transcript levels showed that the general flavonoid pathway regulators PAP1 and PAP2 were up-regulated in response to nitrogen deficiency in wild type as well as pap1D plants.	Flavonoids	61-70	Purple acid phosphatases superfamily protein	Arabidopsis thaliana	99-103
17381106-2	2007	The regulations of apoptosis and the phase II enzymes glutathione-S-transferase (GST) and quinone reductase (QR) are other potential mechanisms through which flavonoids such as anthocyanins may prevent cancer.	Flavonoids	158-168	glutathione S-transferase kappa 1	Homo sapiens	54-79
17381106-2	2007	The regulations of apoptosis and the phase II enzymes glutathione-S-transferase (GST) and quinone reductase (QR) are other potential mechanisms through which flavonoids such as anthocyanins may prevent cancer.	Flavonoids	158-168	glutathione S-transferase kappa 1	Homo sapiens	81-84
17322332-6	2007	CTS function was required for expression of the flavonoid biosynthetic pathway.	Flavonoids	48-57	peroxisomal ABC transporter 1	Arabidopsis thaliana	0-3
17322332-8	2007	In contrast, flavonoids were absent from cts and kat2-1 mutant seeds, but accumulated following the application of sucrose, indicating an essential role for beta-oxidation in inducing flavonoid biosynthetic genes.	Flavonoids	13-23	peroxisomal ABC transporter 1	Arabidopsis thaliana	41-44
17322332-8	2007	In contrast, flavonoids were absent from cts and kat2-1 mutant seeds, but accumulated following the application of sucrose, indicating an essential role for beta-oxidation in inducing flavonoid biosynthetic genes.	Flavonoids	13-22	peroxisomal ABC transporter 1	Arabidopsis thaliana	41-44
17407835-0	2007	Extending the good diet, good health paradigm: modulation of breast cancer resistance protein (BCRP) by flavonoids.	Flavonoids	104-114	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-93
17407835-0	2007	Extending the good diet, good health paradigm: modulation of breast cancer resistance protein (BCRP) by flavonoids.	Flavonoids	104-114	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	95-99
17322161-4	2007	Cranberry juice is a flavonoid, which has been shown to induce, inhibit, or act as a substrate for the biosynthesis of several cytochrome P-450 (CYP) isoenzymes.	Flavonoids	21-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	127-143
17322161-4	2007	Cranberry juice is a flavonoid, which has been shown to induce, inhibit, or act as a substrate for the biosynthesis of several cytochrome P-450 (CYP) isoenzymes.	Flavonoids	21-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	145-148
17012224-7	2007	With this idea in mind, we have assayed the ability of 15 flavonoids to inhibit AHR activated reporter activity and selected kaempferol for further analysis.	Flavonoids	58-68	aryl hydrocarbon receptor	Homo sapiens	80-83
17012224-10	2007	Taken together, these results illustrate the promise associated with the use of flavonoids, that inhibit both AHR signaling and the carcinogenic actions of AHR agonists, for chemopreventive purposes.	Flavonoids	80-90	aryl hydrocarbon receptor	Homo sapiens	110-113
17012224-10	2007	Taken together, these results illustrate the promise associated with the use of flavonoids, that inhibit both AHR signaling and the carcinogenic actions of AHR agonists, for chemopreventive purposes.	Flavonoids	80-90	aryl hydrocarbon receptor	Homo sapiens	156-159
16530937-4	2007	The dietary flavonoid 5,7-dimethoxyflavone significantly inhibited BaP-DNA binding and down-regulated BaP-induced CYP1B1 mRNA and protein.	Flavonoids	12-21	prohibitin 2	Homo sapiens	67-70
17441905-3	2007	Interactions between CXCR4 and flavonoids were investigated using in silico docking studies.	Flavonoids	31-41	C-X-C motif chemokine receptor 4	Homo sapiens	21-26
18050962-0	2007	Glycosylation of flavonoids with E. coli expressing glycosyltransferase from Xanthomonas campestris.	Flavonoids	17-27	glycosyl transferase	Escherichia coli	52-71
17208963-5	2007	In a transient assay, VvMYBPA1 activated the promoters of LAR and ANR, as well as the promoters of several of the general flavonoid pathway genes.	Flavonoids	122-131	MYBPA1 protein	Vitis vinifera	22-30
17476800-0	2007	[Flavonoids: efficient protectors of glucose-6-phosphate dehydrogenase from ultrasonic cavitation-induced inactivation].	Flavonoids	1-11	glucose-6-phosphate dehydrogenase	Homo sapiens	37-70
17476800-1	2007	Seven structurally diverse flavonoids have been shown to decrease glucose-6-phosphate dehydrogenase (G6PDH) inactivation in 0.1 M phosphate buffer (pH 7.4), induced by exposure to a high temperature (44 degrees C), or by a low-frequency ultrasound (27 kHz, 60 Wt/cm2).	Flavonoids	27-37	glucose-6-phosphate dehydrogenase	Homo sapiens	66-99
17476800-1	2007	Seven structurally diverse flavonoids have been shown to decrease glucose-6-phosphate dehydrogenase (G6PDH) inactivation in 0.1 M phosphate buffer (pH 7.4), induced by exposure to a high temperature (44 degrees C), or by a low-frequency ultrasound (27 kHz, 60 Wt/cm2).	Flavonoids	27-37	glucose-6-phosphate dehydrogenase	Homo sapiens	101-106
17184768-4	2007	Both flavonoids significantly inhibited mRNA level of iNOS, COX-2, and CRP.	Flavonoids	5-15	nitric oxide synthase 2	Homo sapiens	54-58
17184768-4	2007	Both flavonoids significantly inhibited mRNA level of iNOS, COX-2, and CRP.	Flavonoids	5-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65
17184768-4	2007	Both flavonoids significantly inhibited mRNA level of iNOS, COX-2, and CRP.	Flavonoids	5-15	C-reactive protein	Homo sapiens	71-74
17184768-6	2007	The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.	Flavonoids	179-189	nitric oxide synthase 2	Homo sapiens	50-54
17184768-6	2007	The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.	Flavonoids	179-189	C-reactive protein	Homo sapiens	66-69
17184768-6	2007	The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.	Flavonoids	179-189	nuclear factor kappa B subunit 1	Homo sapiens	257-266
17253770-7	2007	These findings suggest that flavonoids, especially Myr, exert an anti-amyloidogenic effect in vitro by preferentially and reversibly binding to the amyloid fibril structure of fAbeta, rather than to Abeta monomers.	Flavonoids	28-38	FA complementation group A	Homo sapiens	176-182
17253770-7	2007	These findings suggest that flavonoids, especially Myr, exert an anti-amyloidogenic effect in vitro by preferentially and reversibly binding to the amyloid fibril structure of fAbeta, rather than to Abeta monomers.	Flavonoids	28-38	amyloid beta precursor protein	Homo sapiens	177-182
17364964-0	2007	The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron.	Flavonoids	4-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-63
17364964-0	2007	The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron.	Flavonoids	4-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
17364964-1	2007	Quercetin, a flavonoid with anti-oxidant, metal chelating, kinase modulating and anti-proliferative properties, can induce hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia, but its mechanism of action has not been determined.	Flavonoids	13-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-166
17364965-4	2007	SP-A isolated from alveolar proteinosis patients was exposed to ozone (1 ppm) for 4 h. The flavonoids protected SP-A from oxidation in a dose dependent manner.	Flavonoids	91-101	surfactant protein A1	Homo sapiens	0-4
17364965-4	2007	SP-A isolated from alveolar proteinosis patients was exposed to ozone (1 ppm) for 4 h. The flavonoids protected SP-A from oxidation in a dose dependent manner.	Flavonoids	91-101	surfactant protein A1	Homo sapiens	112-116
17184768-1	2007	We examined the ability of the flavonoids quercetin and kaempferol to modulate inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reactive C-protein (CRP) expression, and to induce changes in the nuclear factor kappa B (NF-kappaB) pathway in the human hepatocyte-derived cell line Chang Liver.	Flavonoids	31-41	nitric oxide synthase 2	Homo sapiens	112-116
17184768-1	2007	We examined the ability of the flavonoids quercetin and kaempferol to modulate inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reactive C-protein (CRP) expression, and to induce changes in the nuclear factor kappa B (NF-kappaB) pathway in the human hepatocyte-derived cell line Chang Liver.	Flavonoids	31-41	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-135
16530937-4	2007	The dietary flavonoid 5,7-dimethoxyflavone significantly inhibited BaP-DNA binding and down-regulated BaP-induced CYP1B1 mRNA and protein.	Flavonoids	12-21	prohibitin 2	Homo sapiens	102-105
16530937-4	2007	The dietary flavonoid 5,7-dimethoxyflavone significantly inhibited BaP-DNA binding and down-regulated BaP-induced CYP1B1 mRNA and protein.	Flavonoids	12-21	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	114-120
17268053-6	2007	From these results, it was for the first time suggested that the binding of flavonoids to the heme moiety or a protein region of catalase contributes to the enhancement of catalase activity.	Flavonoids	76-86	catalase	Homo sapiens	129-137
17268053-0	2007	Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method.	Flavonoids	53-63	catalase	Homo sapiens	71-79
17268053-2	2007	In the present study, to evaluate the antioxidative effect of several types of flavonoids on catalase activity at a physiological H2O2 concentration, a chemiluminescent (CL) method was used.	Flavonoids	79-89	catalase	Homo sapiens	93-101
17268053-6	2007	From these results, it was for the first time suggested that the binding of flavonoids to the heme moiety or a protein region of catalase contributes to the enhancement of catalase activity.	Flavonoids	76-86	catalase	Homo sapiens	172-180
17108059-1	2007	The objective of this study was to determine the effects of flavonoids on the in vitro monocarboxylate transporter 1 (MCT1)-mediated transport and in vivo disposition of the drug of abuse, gamma-hydroxybutyrate (GHB).	Flavonoids	60-70	solute carrier family 16 member 1	Rattus norvegicus	87-116
17158054-0	2007	Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.	Flavonoids	14-24	cell division cycle 123	Homo sapiens	47-53
17108059-1	2007	The objective of this study was to determine the effects of flavonoids on the in vitro monocarboxylate transporter 1 (MCT1)-mediated transport and in vivo disposition of the drug of abuse, gamma-hydroxybutyrate (GHB).	Flavonoids	60-70	solute carrier family 16 member 1	Rattus norvegicus	118-122
17108059-2	2007	The uptake of GHB in rat MCT1 gene-transfected MDA-MB231 cells was significantly decreased in the presence of the flavonoids apigenin, biochanin A, chrysin, diosemin, fisetin, genistein, hesperitin, kaempferol, luteolin, morin, narigenin, phloretin, and quercetin, but was not affected by the flavonoid glycosides phloridzin and rutin.	Flavonoids	114-124	solute carrier family 16 member 1	Rattus norvegicus	25-29
17093006-2	2007	Flavonoids, a large class of natural compounds widely present in the diet and herbal products, have been shown in vitro to be BCRP inhibitors.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	126-130
17093006-3	2007	The flavonoid chrysin is a potent inhibitor of BCRP, inhibiting the efflux of mitoxantrone with an IC(50) of 0.39 microM in BCRP-overexpressing human MCF-7 breast cancer cells.	Flavonoids	4-13	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-51
17093006-3	2007	The flavonoid chrysin is a potent inhibitor of BCRP, inhibiting the efflux of mitoxantrone with an IC(50) of 0.39 microM in BCRP-overexpressing human MCF-7 breast cancer cells.	Flavonoids	4-13	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	124-128
17108059-2	2007	The uptake of GHB in rat MCT1 gene-transfected MDA-MB231 cells was significantly decreased in the presence of the flavonoids apigenin, biochanin A, chrysin, diosemin, fisetin, genistein, hesperitin, kaempferol, luteolin, morin, narigenin, phloretin, and quercetin, but was not affected by the flavonoid glycosides phloridzin and rutin.	Flavonoids	114-123	solute carrier family 16 member 1	Rattus norvegicus	25-29
16962273-0	2007	Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases.	Flavonoids	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	106-119
17093006-12	2007	Taken together, these results indicate that the flavonoid chrysin significantly inhibits nitrofurantoin transport mediated by human BCRP and murine Bcrp1.	Flavonoids	48-57	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	132-136
17093006-12	2007	Taken together, these results indicate that the flavonoid chrysin significantly inhibits nitrofurantoin transport mediated by human BCRP and murine Bcrp1.	Flavonoids	48-57	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	148-153
17256720-1	2007	UNLABELLED: The flavonoid chrysin is an important dietary substance and induces UGT1A1 protein expression in cell culture.	Flavonoids	16-25	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	80-86
17256720-2	2007	As a representative of the class of dietary flavonoids, clinical investigations have been considered as a means of inducing hepatic UGT1A1 expression.	Flavonoids	44-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	132-138
17172639-0	2007	Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.	Flavonoids	58-68	solute carrier family 2 member 2	Homo sapiens	49-54
17172639-3	2007	Robust inhibition of glucose and fructose transport by GLUT2 expressed in Xenopus laevis oocytes was produced by the flavonols myricetin, fisetin, the widely consumed flavonoid quercetin, and its glucoside precursor isoquercitrin [corrected].	Flavonoids	167-176	solute carrier family 2 member 2 S homeolog	Xenopus laevis	55-60
16427264-0	2007	Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids.	Flavonoids	68-78	translocator protein	Homo sapiens	16-19
16427264-1	2007	To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed.	Flavonoids	105-115	translocator protein	Homo sapiens	41-75
16427264-1	2007	To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed.	Flavonoids	105-115	translocator protein	Homo sapiens	77-80
16427264-1	2007	To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed.	Flavonoids	162-172	translocator protein	Homo sapiens	41-75
16427264-1	2007	To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed.	Flavonoids	162-172	translocator protein	Homo sapiens	77-80
16427264-4	2007	Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands.	Flavonoids	8-18	translocator protein	Homo sapiens	102-105
16427264-5	2007	Treatment of 10(-6) M flavonoids for 6 days elevated the expression of PBR mRNA in cells.	Flavonoids	22-32	translocator protein	Homo sapiens	71-74
16427264-6	2007	These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.	Flavonoids	46-56	translocator protein	Homo sapiens	127-130
18525112-8	2007	Furthermore, the flavonoid (4-50 microM) attenuated receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclastogenesis of RAW264.7 cells, as detected by tartarate-resistant acid phosphatase activity and microscopic observations.	Flavonoids	17-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	52-102
17055466-0	2007	The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2.	Flavonoids	12-21	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	42-46
18525112-8	2007	Furthermore, the flavonoid (4-50 microM) attenuated receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclastogenesis of RAW264.7 cells, as detected by tartarate-resistant acid phosphatase activity and microscopic observations.	Flavonoids	17-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	104-109
17346166-0	2007	SAR and QSAR of the antioxidant activity of flavonoids.	Flavonoids	44-54	sarcosine dehydrogenase	Homo sapiens	0-3
17085048-0	2007	Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: design, synthesis, and biological evaluation.	Flavonoids	20-30	cyclin dependent kinase 1	Homo sapiens	34-38
17085048-1	2007	A novel series of nitrogen-containing flavonoids 5a-l, 6a,b, and 7a,b were designed and synthesized as cyclin-dependent kinases (CDKs) inhibitors.	Flavonoids	38-48	cyclin dependent kinase 1	Homo sapiens	129-133
16777995-5	2007	The purpose of this study was to determine whether common flavonoids, genistein and quercetin, increase connexin43 (Cx43) levels, improve GJIC and suppress growth of a metastatic human breast tumor cell line (MDA-MB-231).	Flavonoids	58-68	gap junction protein alpha 1	Homo sapiens	104-114
16777995-5	2007	The purpose of this study was to determine whether common flavonoids, genistein and quercetin, increase connexin43 (Cx43) levels, improve GJIC and suppress growth of a metastatic human breast tumor cell line (MDA-MB-231).	Flavonoids	58-68	gap junction protein alpha 1	Homo sapiens	116-120
17982275-0	2007	The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perfused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase.	Flavonoids	4-13	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	120-141
17346166-7	2007	SAR and QSAR can provide useful tools for revealing the nature of flavonoid antioxidant action.	Flavonoids	66-75	sarcosine dehydrogenase	Homo sapiens	0-3
18261373-2	2007	In this study, eleven flavonoids containing a variety of hydroxy (OH) and/or methoxy (OMe) groups were evaluated for their antioxidant, cytotoxic and chemosensitizing effects to create a structure-activity relationship (SAR).	Flavonoids	22-32	sarcosine dehydrogenase	Homo sapiens	187-224
18274639-0	2007	Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.	Flavonoids	29-39	signal transducer and activator of transcription 1	Homo sapiens	96-102
18274639-0	2007	Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.	Flavonoids	29-39	nitric oxide synthase 2	Homo sapiens	262-266
17218638-5	2007	Resolution of the crystal structure of PIM1 in complex with quercetagetin or two other flavonoids revealed a spectrum of binding poses and hydrogen-bonding patterns in spite of strong similarity of the ligands.	Flavonoids	87-97	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	39-43
17456040-12	2007	But in terms of PLA2 inhibition and antioxidant activity, the structural aspects of flavonoids are well studied rather than terpenes and alkaloids.	Flavonoids	84-94	phospholipase A2 group VI	Homo sapiens	16-20
18261373-9	2007	CONCLUSIONS: These results suggest that flavonoids with 3-OH group play a positive role in antioxidant activities, flavonoids with 5-OH and/or 7-OH groups show the higher cytotoxicity, and flavonoids with 3"-OMe and/or 5"-OMe groups plays positive but 6-OMe groups negative roles in the P-glycoprotein (Pgp) inhibition.	Flavonoids	115-125	ATP binding cassette subfamily B member 1	Homo sapiens	287-301
18261373-9	2007	CONCLUSIONS: These results suggest that flavonoids with 3-OH group play a positive role in antioxidant activities, flavonoids with 5-OH and/or 7-OH groups show the higher cytotoxicity, and flavonoids with 3"-OMe and/or 5"-OMe groups plays positive but 6-OMe groups negative roles in the P-glycoprotein (Pgp) inhibition.	Flavonoids	115-125	ATP binding cassette subfamily B member 1	Homo sapiens	303-306
18261373-9	2007	CONCLUSIONS: These results suggest that flavonoids with 3-OH group play a positive role in antioxidant activities, flavonoids with 5-OH and/or 7-OH groups show the higher cytotoxicity, and flavonoids with 3"-OMe and/or 5"-OMe groups plays positive but 6-OMe groups negative roles in the P-glycoprotein (Pgp) inhibition.	Flavonoids	115-125	ATP binding cassette subfamily B member 1	Homo sapiens	287-301
18261373-9	2007	CONCLUSIONS: These results suggest that flavonoids with 3-OH group play a positive role in antioxidant activities, flavonoids with 5-OH and/or 7-OH groups show the higher cytotoxicity, and flavonoids with 3"-OMe and/or 5"-OMe groups plays positive but 6-OMe groups negative roles in the P-glycoprotein (Pgp) inhibition.	Flavonoids	115-125	ATP binding cassette subfamily B member 1	Homo sapiens	303-306
18261373-10	2007	It is believed that these SAR results can be taken into account for the development of flavonoids with high therapeutic index.	Flavonoids	87-97	sarcosine dehydrogenase	Homo sapiens	26-29
18261374-2	2007	The aim of this study was to select a P-glycoprotein (Pgp)- inhibitory flavonoid to enhance paclitaxel bioavailability in the Caco-2 cell monolayer.	Flavonoids	71-80	ATP binding cassette subfamily B member 1	Homo sapiens	38-52
18261374-2	2007	The aim of this study was to select a P-glycoprotein (Pgp)- inhibitory flavonoid to enhance paclitaxel bioavailability in the Caco-2 cell monolayer.	Flavonoids	71-80	ATP binding cassette subfamily B member 1	Homo sapiens	54-57
18221055-5	2007	The others are synthetic flavonoids including FAA and DMXAA that induce the production of local cytokines such as TNF-alpha.	Flavonoids	25-35	tumor necrosis factor	Homo sapiens	114-123
17635218-4	2007	Constitutive overexpression and RNAi-mediated silencing of AtDOF4;2 caused reciprocal changes in the expression of flavonoid biosynthetic genes and the accumulation of flavonoids under cold and high-light conditions.	Flavonoids	115-124	Dof-type zinc finger domain-containing protein	Arabidopsis thaliana	59-67
17635218-4	2007	Constitutive overexpression and RNAi-mediated silencing of AtDOF4;2 caused reciprocal changes in the expression of flavonoid biosynthetic genes and the accumulation of flavonoids under cold and high-light conditions.	Flavonoids	168-178	Dof-type zinc finger domain-containing protein	Arabidopsis thaliana	59-67
17635218-6	2007	In contrast to its negative influence on flavonoid biosynthesis and coincident with high expression in the periderm and tapetum, AtDOF4;2 positively influences the production of hydroxycinnamic acids in the hypocotyl and flower buds, implicating its possible importance for suberin and sporopollenin production.	Flavonoids	41-50	Dof-type zinc finger domain-containing protein	Arabidopsis thaliana	129-137
17120136-9	2007	Analysis of gene co-expression clusters in Arabidopsis suggests a role for peroxisomal KAT2 in beta-oxidation, while KAT5 co-expresses with genes of the flavonoid biosynthesis pathway and cytosolic ACAT2 clearly co-expresses with genes of the cytosolic mevalonate biosynthesis pathway.	Flavonoids	153-162	peroxisomal 3-keto-acyl-CoA thiolase 2	Arabidopsis thaliana	117-121
17237352-2	2007	We show that, in HCT-silenced plants, lignin synthesis repression leads to the redirection of the metabolic flux into flavonoids through chalcone synthase activity.	Flavonoids	118-128	hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase	Arabidopsis thaliana	17-20
17237352-8	2007	Suppression of flavonoid accumulation by chalcone synthase repression in HCT-deficient plants restored normal auxin transport and wild-type plant growth.	Flavonoids	15-24	hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase	Arabidopsis thaliana	73-76
17237352-10	2007	These data demonstrate that the reduced size phenotype of HCT-silenced plants is not due to the alteration of lignin synthesis but to flavonoid accumulation.	Flavonoids	134-143	hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase	Arabidopsis thaliana	58-61
17302199-10	2007	NAC and the flavonoids all suppressed the IkB/NF-kappaB signaling pathway even in the presence of NF-kappaB stimulation by TNFalpha, and showed reduced expression of many NF-kappaB target genes.	Flavonoids	12-22	nuclear factor kappa B subunit 1	Homo sapiens	46-55
17302199-10	2007	NAC and the flavonoids all suppressed the IkB/NF-kappaB signaling pathway even in the presence of NF-kappaB stimulation by TNFalpha, and showed reduced expression of many NF-kappaB target genes.	Flavonoids	12-22	nuclear factor kappa B subunit 1	Homo sapiens	98-107
17302199-10	2007	NAC and the flavonoids all suppressed the IkB/NF-kappaB signaling pathway even in the presence of NF-kappaB stimulation by TNFalpha, and showed reduced expression of many NF-kappaB target genes.	Flavonoids	12-22	tumor necrosis factor	Homo sapiens	123-131
17302199-10	2007	NAC and the flavonoids all suppressed the IkB/NF-kappaB signaling pathway even in the presence of NF-kappaB stimulation by TNFalpha, and showed reduced expression of many NF-kappaB target genes.	Flavonoids	12-22	nuclear factor kappa B subunit 1	Homo sapiens	98-107
16988947-11	2006	Thus, plant-derived flavonoids cause cell death with activation of proteolytic activities of calpain and caspases in SH-SY5Y cells, and therefore serve as potential therapeutic agents for controlling the growth of neuroblastoma.	Flavonoids	20-30	caspase 8	Homo sapiens	105-113
17396564-1	2007	Phytogenous flavonoid-containing agents (PFCA) are able to initiate electron flow bypassing the NAD-dependent region of respiratory chain, which is related with the activity of DT-diaphorase catalyzing two-electron reduction of quinones to hydroquinones and hydrogen peroxide in the presence of NADH and oxygen.	Flavonoids	12-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	177-190
16552572-7	2006	Flavonoids were incubated with cells for 6 or 24 h and COX-2 protein expression and PGE-2 levels were assessed by Western blot and competitive immunoassay, respectively.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
17014893-0	2007	The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPC.	Flavonoids	16-25	coagulation factor III, tissue factor	Homo sapiens	46-59
17520800-3	2007	This review focuses on the flavonoid effects on cytochrome P450 (CYP) enzyme CYP1, 2E1, 3A4 and 19.	Flavonoids	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	48-63
17520800-3	2007	This review focuses on the flavonoid effects on cytochrome P450 (CYP) enzyme CYP1, 2E1, 3A4 and 19.	Flavonoids	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-68
17520800-4	2007	Flavonoids alter CYPs by various mechanisms, including the stimulation of gene expression via specific receptors and/or CYP protein, or mRNA stabilization and so on.	Flavonoids	0-10	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
17052690-2	2006	In this study, we examined the inhibitory effect of three major flavonoids in Scutellariae Radix, baicalin, baicalein, and wogonin, on TNF-alpha-induced MMP-9 expression in human aortic smooth muscle cells (HASMC).	Flavonoids	64-74	tumor necrosis factor	Homo sapiens	135-144
17052690-2	2006	In this study, we examined the inhibitory effect of three major flavonoids in Scutellariae Radix, baicalin, baicalein, and wogonin, on TNF-alpha-induced MMP-9 expression in human aortic smooth muscle cells (HASMC).	Flavonoids	64-74	matrix metallopeptidase 9	Homo sapiens	153-158
16987811-4	2006	We found that the capacity of flavonoids to inhibit tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells was dependent on specific structural features of the flavonoids.	Flavonoids	30-40	tumor necrosis factor	Homo sapiens	52-79
17157668-1	2006	BACKGROUND: The green tea flavonoid, epigallocatechin gallate (EGCG), has been proposed to have an anti-HIV-1 effect by preventing the binding of HIV-1 glycoprotein (gp) 120 to the CD4 molecule on T cells.	Flavonoids	26-35	CD4 molecule	Homo sapiens	181-184
16987811-4	2006	We found that the capacity of flavonoids to inhibit tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells was dependent on specific structural features of the flavonoids.	Flavonoids	204-214	tumor necrosis factor	Homo sapiens	52-79
16987811-8	2006	At low concentrations, the active flavonoids significantly attenuated expression of E-selectin and intercellular adhesion molecule 1 but not vascular cell adhesion molecule 1.	Flavonoids	34-44	selectin E	Homo sapiens	84-94
16987811-8	2006	At low concentrations, the active flavonoids significantly attenuated expression of E-selectin and intercellular adhesion molecule 1 but not vascular cell adhesion molecule 1.	Flavonoids	34-44	intercellular adhesion molecule 1	Homo sapiens	99-132
16987811-9	2006	In addition, exposure of apigenin and kaempferol to cultured hepatocytes, mimicking first pass metabolism, greatly diminished the inhibitory effect of flavonoids on endothelial intercellular adhesion molecule 1 expression.	Flavonoids	151-161	intercellular adhesion molecule 1	Homo sapiens	177-210
17159770-4	2006	Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody.	Flavonoids	29-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	54-73
17159770-4	2006	Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody.	Flavonoids	29-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	224-243
17159770-4	2006	Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody.	Flavonoids	166-176	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	54-73
17159770-5	2006	RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver.	Flavonoids	24-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
17159770-5	2006	RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver.	Flavonoids	24-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
17154505-0	2006	Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.	Flavonoids	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	44-58
16997339-5	2006	Additional experiments revealed that the apical to basolateral PhIP transport was also increased in the presence of a typical BCRP or MRP inhibitor with apparent Ki values in the same range as those of the flavonoids.	Flavonoids	206-216	BCR pseudogene 1	Homo sapiens	126-130
16997339-5	2006	Additional experiments revealed that the apical to basolateral PhIP transport was also increased in the presence of a typical BCRP or MRP inhibitor with apparent Ki values in the same range as those of the flavonoids.	Flavonoids	206-216	ATP binding cassette subfamily C member 1	Homo sapiens	134-137
16997339-6	2006	This observation together with the fact that flavonoids are known to be inhibitors of MRPs and BCRP, corroborates that inhibition of these apical membrane transporters is involved in the flavonoid-mediated increased apical to basolateral PhIP transport.	Flavonoids	45-55	BCR pseudogene 1	Homo sapiens	95-99
16997339-6	2006	This observation together with the fact that flavonoids are known to be inhibitors of MRPs and BCRP, corroborates that inhibition of these apical membrane transporters is involved in the flavonoid-mediated increased apical to basolateral PhIP transport.	Flavonoids	45-54	BCR pseudogene 1	Homo sapiens	95-99
17154505-2	2006	Our approach was to target the binding sites of P-gp using dimers of dietary flavonoids.	Flavonoids	77-87	phosphoglycolate phosphatase	Homo sapiens	48-52
16919944-5	2006	However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.	Flavonoids	9-19	acetyl-CoA acetyltransferase 2	Homo sapiens	56-63
17090139-0	2006	TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers.	Flavonoids	78-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
17059987-3	2006	We report a patient who developed acute renal failure, acute hepatic failure, autoimmune hemolytic anemia, and thrombocytopenia after oral intake of hot-water extract of Cupressus funebris Endl (Mourning Cypress), which is rich in flavonoids.	Flavonoids	231-241	alcohol dehydrogenase iron containing 1	Homo sapiens	149-152
16891119-0	2006	Flavonoids and cinnamic acid esters as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase: a synthesis, QSAR and modelling study.	Flavonoids	0-10	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	60-95
17090139-1	2006	Since the toxicological effects of dioxins are mainly mediated by the aryl hydrocarbon receptor (AhR), an in vitro assessment system for AhR activity was used in this study to search for flavonoids that attenuated dioxin toxicity through the intestinal epithelial monolayer.	Flavonoids	187-197	aryl hydrocarbon receptor	Homo sapiens	70-95
17090139-1	2006	Since the toxicological effects of dioxins are mainly mediated by the aryl hydrocarbon receptor (AhR), an in vitro assessment system for AhR activity was used in this study to search for flavonoids that attenuated dioxin toxicity through the intestinal epithelial monolayer.	Flavonoids	187-197	aryl hydrocarbon receptor	Homo sapiens	97-100
17090139-1	2006	Since the toxicological effects of dioxins are mainly mediated by the aryl hydrocarbon receptor (AhR), an in vitro assessment system for AhR activity was used in this study to search for flavonoids that attenuated dioxin toxicity through the intestinal epithelial monolayer.	Flavonoids	187-197	aryl hydrocarbon receptor	Homo sapiens	137-140
17090139-2	2006	When AhR transformation in Hepa-1c1c7 cells was examined by southwestern ELISA, nine flavonoids among 34 kinds of flavonoids inhibited the transformation by more than one-half.	Flavonoids	85-95	aryl-hydrocarbon receptor	Mus musculus	5-8
17090139-2	2006	When AhR transformation in Hepa-1c1c7 cells was examined by southwestern ELISA, nine flavonoids among 34 kinds of flavonoids inhibited the transformation by more than one-half.	Flavonoids	114-124	aryl-hydrocarbon receptor	Mus musculus	5-8
17090139-3	2006	When each flavonoid with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was added to dioxin-responsive HepG2 cells, seven flavonoids significantly restrained the TCDD-induced transcriptional activity of the CYP1A1 promoter.	Flavonoids	10-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	203-209
17090139-3	2006	When each flavonoid with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was added to dioxin-responsive HepG2 cells, seven flavonoids significantly restrained the TCDD-induced transcriptional activity of the CYP1A1 promoter.	Flavonoids	118-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	203-209
17090139-4	2006	Furthermore, those seven flavonoids that had permeated the Caco-2 cell monolayers demonstrated an inhibitory effect on both the AhR transformation and on the transcriptional activity of the CYP1A1 promoter.	Flavonoids	25-35	aryl hydrocarbon receptor	Homo sapiens	128-131
17090139-4	2006	Furthermore, those seven flavonoids that had permeated the Caco-2 cell monolayers demonstrated an inhibitory effect on both the AhR transformation and on the transcriptional activity of the CYP1A1 promoter.	Flavonoids	25-35	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	190-196
17090139-6	2006	It is proposed from these results that some flavonoids have the ability to suppress dioxin-induced AhR activity after permeating the human intestinal epithelial cell monolayer.	Flavonoids	44-54	aryl hydrocarbon receptor	Homo sapiens	99-102
16978825-0	2006	Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients.	Flavonoids	0-9	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	44-47
16978825-5	2006	The present paper focuses on the role of flavonoids as important modulators or substrates of intestinal ABC transport proteins.	Flavonoids	41-51	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	104-107
16978825-7	2006	It can be concluded that flavonoid-mediated inhibition of ABC transporters may affect the bioavailability of drugs, bioactive food ingredients and/or food-borne toxic compounds upon oral uptake.	Flavonoids	25-34	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	58-61
16978825-8	2006	All together it appears that the flavonoid-mediated interactions at the level of the intestinal ABC transport proteins may be an important mechanism for unexpected food-drug, food-toxin or food-food interactions.	Flavonoids	33-42	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	96-99
16978825-9	2006	The overview also indicates that future studies should focus on i) in vivo validation of the flavonoid-mediated effects on bioavailability of drugs, toxins and beneficial bioactive food ingredients detected in in vitro models, and on ii) the role of flavonoid phase II metabolism in modulating the activity of the flavonoids to act as ABC transporter inhibitors and/or substrates.	Flavonoids	93-102	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	335-338
16934962-7	2006	It is concluded that flavonoids, such as naringenin and isoquercitrin, inhibit an inside-directed process in addition to their inhibition of P-glycoprotein-mediated exsorption.	Flavonoids	21-31	ATP binding cassette subfamily B member 1	Homo sapiens	141-155
17014487-6	2006	Thus, this review first summarizes the conventional roles of flavonoids as nod gene inducers, phytoalexins and allelochemicals before exploring questions concerning "non-target" impacts.	Flavonoids	61-71	atrophin 1	Homo sapiens	75-78
16979127-2	2006	Some flavonoids have been reported previously to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.	Flavonoids	5-15	nitric oxide synthase 2, inducible	Mus musculus	162-166
16979127-4	2006	Western blotting showed that all flavonoids suppressed the induction of both iNOS and COX-2.	Flavonoids	33-43	nitric oxide synthase 2, inducible	Mus musculus	77-81
16979127-6	2006	This study suggests that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects, and that they may be potential agents for use in the treatment of inflammatory diseases.	Flavonoids	68-78	nitric oxide synthase 2, inducible	Mus musculus	39-43
17132221-3	2006	The goal of this study was to determine whether the antiproliferative action of these flavonoids on prostate (DU-145) and breast (MDA-MB-231) cancer cells expressing only estrogen receptor (ER) beta is mediated by this ER subtype.	Flavonoids	86-96	estrogen receptor 1	Homo sapiens	171-188
16713650-2	2006	POMT-7 was able to transfer a methyl group to several flavonoids containing a C-7 hydroxyl group.	Flavonoids	54-64	complement C7	Homo sapiens	78-81
17056790-5	2006	Moreover, this flavonoid decreased the Bcl-xL:Bcl-xS ratio and increased translocation of Bax to the mitochondrial membrane.	Flavonoids	15-24	BCL2 like 1	Homo sapiens	39-45
17056790-5	2006	Moreover, this flavonoid decreased the Bcl-xL:Bcl-xS ratio and increased translocation of Bax to the mitochondrial membrane.	Flavonoids	15-24	BCL2 associated X, apoptosis regulator	Homo sapiens	90-93
17125223-0	2006	Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.	Flavonoids	69-79	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	0-31
17132221-3	2006	The goal of this study was to determine whether the antiproliferative action of these flavonoids on prostate (DU-145) and breast (MDA-MB-231) cancer cells expressing only estrogen receptor (ER) beta is mediated by this ER subtype.	Flavonoids	86-96	estrogen receptor 1	Homo sapiens	190-192
17132221-3	2006	The goal of this study was to determine whether the antiproliferative action of these flavonoids on prostate (DU-145) and breast (MDA-MB-231) cancer cells expressing only estrogen receptor (ER) beta is mediated by this ER subtype.	Flavonoids	86-96	estrogen receptor 1	Homo sapiens	219-221
17132221-5	2006	In yeast transcription assays, both flavonoids displayed high specificity toward ERbeta transactivation, particularly at lower concentrations.	Flavonoids	36-46	estrogen receptor 2	Homo sapiens	81-87
16934226-5	2006	In this regard, we demonstrated that most of the flavonoids assayed reduce macrophage M-CSF-induced proliferation without affecting cellular viability.	Flavonoids	49-59	colony stimulating factor 1 (macrophage)	Mus musculus	86-91
16890919-11	2006	Biochem Pharmacol 2006;71:1570-80] it appears that although Hst5 and 1B4 are synthesized in salivary glands they have an important biological function in the intestines as scavenger molecules preventing uptake of tannin but without notably affecting absorption of flavonoids.	Flavonoids	264-274	histatin 3	Homo sapiens	60-64
17006974-2	2006	In a radioligand binding assay for A(1) adenosine receptor occupancy in particulate preparations from guinea-pig cerebral cortex, flavonoids competed in concentration-dependent manners with Hill slopes typically not different from unity.	Flavonoids	130-140	adenosine receptor A1	Cavia porcellus	35-58
17006974-5	2006	These data suggest, therefore, that flavonoids represent an additional dietary source of A(1) adenosine receptor antagonists (beyond the methylxanthines, caffeine and theophylline).	Flavonoids	36-46	adenosine receptor A1	Cavia porcellus	89-112
17050681-0	2006	Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory.	Flavonoids	0-9	Eph receptor B1	Rattus norvegicus	27-30
17050681-2	2006	Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice.	Flavonoids	22-31	Eph receptor B1	Rattus norvegicus	50-53
17050681-2	2006	Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice.	Flavonoids	22-31	cAMP responsive element binding protein 1	Rattus norvegicus	66-103
17050681-2	2006	Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice.	Flavonoids	22-31	cAMP responsive element binding protein 1	Rattus norvegicus	105-109
16934226-6	2006	Moreover, some flavonoids also inhibit TNFalpha production as well as iNOS expression and NO production in LPS-activated macrophages, an effect that has been associated with the inhibition of the NF-kappaB pathway.	Flavonoids	15-25	tumor necrosis factor	Mus musculus	39-47
16934226-6	2006	Moreover, some flavonoids also inhibit TNFalpha production as well as iNOS expression and NO production in LPS-activated macrophages, an effect that has been associated with the inhibition of the NF-kappaB pathway.	Flavonoids	15-25	nitric oxide synthase 2, inducible	Mus musculus	70-74
17015250-4	2006	In vitro studies show that flavonoids may exert multiple actions on the NO-guanylyl cyclase pathway, endothelium-derived hyperpolarizing factor(s) and endothelin-1 and protect endothelial cells against apoptosis.	Flavonoids	27-37	endothelin 1	Homo sapiens	151-163
16891302-9	2006	A phylogenetic analysis revealed that GmICHG is a member of glycoside hydrolase family 1 and can be co-clustered with many other leguminous beta-glucosidases, the majority of which may also be involved in flavonoid-mediated interactions of legumes with microbes.	Flavonoids	205-214	isoflavone conjugate-specific beta-glucosidase	Glycine max	38-44
17018623-8	2006	Inhibition of SULTs and cytochrome P450 (CYP) enzymes by natural flavonoids blocked the antiproliferative activity of AF and the formation of AF-DNA adducts.	Flavonoids	65-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-39
17018623-8	2006	Inhibition of SULTs and cytochrome P450 (CYP) enzymes by natural flavonoids blocked the antiproliferative activity of AF and the formation of AF-DNA adducts.	Flavonoids	65-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	41-44
16887337-4	2006	HAN11 is the human homologue of AN11, which controls flavonoid synthesis in plants.	Flavonoids	53-62	DDB1 and CUL4 associated factor 7	Homo sapiens	0-5
16887337-4	2006	HAN11 is the human homologue of AN11, which controls flavonoid synthesis in plants.	Flavonoids	53-62	DDB1 and CUL4 associated factor 7	Homo sapiens	1-5
16890209-11	2006	Therefore, our results suggest that green tea flavonoids can modulate both MyD88- and TRIF-dependent signaling pathways of TLRs and subsequent inflammatory target gene expression.	Flavonoids	46-56	MYD88 innate immune signal transduction adaptor	Homo sapiens	75-80
16890209-11	2006	Therefore, our results suggest that green tea flavonoids can modulate both MyD88- and TRIF-dependent signaling pathways of TLRs and subsequent inflammatory target gene expression.	Flavonoids	46-56	TIR domain containing adaptor molecule 1	Homo sapiens	86-90
16738032-1	2006	UDP-glucuronosyltransferase 1A3 (UGT1A3) contributes to glucuronidation of many important endogenous compounds and xenobiotics, including some flavonoids.	Flavonoids	143-153	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	0-31
16530158-0	2006	The effects of the flavonoid baicalein and osmolytes on the Mg 2+ accelerated aggregation/fibrillation of carboxymethylated bovine 1SS-alpha-lactalbumin.	Flavonoids	19-28	lactalbumin alpha	Bos taurus	135-152
16530158-6	2006	Most importantly however, the flavonoid, baicalein, known to inhibit alpha-synuclein amyloid fibril formation, also inhibits 1SS-alpha-lac amyloid with the same apparent efficacy.	Flavonoids	30-39	synuclein alpha	Bos taurus	69-84
16922812-0	2006	Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes.	Flavonoids	52-62	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	66-73
16922812-0	2006	Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes.	Flavonoids	52-62	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	78-84
16738032-1	2006	UDP-glucuronosyltransferase 1A3 (UGT1A3) contributes to glucuronidation of many important endogenous compounds and xenobiotics, including some flavonoids.	Flavonoids	143-153	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	33-39
16738032-5	2006	In the present study, three common flavonoids, quercetin, luteolin, and kaempferol, were used as substrates for glucuronidation by wild-type and variant UGT1A3s.	Flavonoids	35-45	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	153-159
16690199-0	2006	Flavonoids inhibit the amidolytic activity of human thrombin.	Flavonoids	0-10	coagulation factor II, thrombin	Homo sapiens	52-60
16690199-1	2006	The effect of a group of natural flavonoids on human thrombin amidolytic activity was investigated using a spectrophotometric inhibition assay while information on the kinetics and thermodynamics was obtained using optical biosensor techniques.	Flavonoids	33-43	coagulation factor II, thrombin	Homo sapiens	53-61
16690199-2	2006	All the flavonoids tested acted as reversible inhibitors, and the quercetin-thrombin complex was found to be most stable at pH=7.5.	Flavonoids	8-18	coagulation factor II, thrombin	Homo sapiens	76-84
16738032-9	2006	UGT1A3 variants have an altered glucuronidation activity toward quercetin, luteolin, and kaempferol and may alter human susceptibility to flavonoid exposure.	Flavonoids	138-147	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	0-6
16575575-1	2006	Chalcone synthase (CHS) catalyzes the first committed step in flavonoid biosynthesis, a major pathway of plant secondary metabolism.	Flavonoids	62-71	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	19-22
16946397-7	2006	Indeed, the three-dimensional structure of many flavonoids is sterically and electrostatically compatible with the catalytic site of cAMP PDE3 and PDE4.	Flavonoids	48-58	phosphodiesterase 4A	Homo sapiens	147-151
16846465-0	2006	Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep.	Flavonoids	93-103	broad substrate specificity ATP-binding cassette transporter ABCG2	Ovis aries	67-71
16950806-2	2006	Recently, both flavonoids have been reported to inhibit DNA topoisomerases I and II (topo I and topo II), a property that, together with their ability to induce DNA and chromosome damage, has made them candidate anticancer compounds.	Flavonoids	15-25	DNA topoisomerase 1	Cricetulus griseus	56-83
16814519-7	2006	The flavonoid extract applied as a single dietary supplement was observed to decrease the activity of bacterial beta-glucosidase and beta- and alpha-galactosidases in the cecal digesta.	Flavonoids	4-13	galactosidase, beta 1	Rattus norvegicus	133-163
16484233-13	2006	Two methoxylated dietary flavonoids with highly specific effects on BaP bioactivation block this DNA binding and CYP1A1 protein expression as effectively as RV, thus making them potential chemopreventive agents for BaP-induced lung carcinogenesis.	Flavonoids	25-35	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
16721748-6	2006	The stimulatory effects of B[a]P on expression of these genes were abrogated by cotreatment with the AhR antagonist flavonoid, alpha-napthoflavone (ANF).	Flavonoids	116-125	aryl hydrocarbon receptor	Homo sapiens	101-104
16806698-16	2006	These results demonstrate that quercetin, a natural flavonoid reduces global ischemia-induced neuronal damage through inhibition of MMP-9 activity.	Flavonoids	52-61	matrix metallopeptidase 9	Mus musculus	132-137
16945047-1	2006	STUDY OBJECTIVES: To determine if quercetin, a bioflavonoid that inhibits p-glycoprotein, alters plasma saquinavir concentrations, and to explore the potential influence on intracellular concentrations.	Flavonoids	47-59	ATP binding cassette subfamily B member 1	Homo sapiens	74-88
16777073-0	2006	The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells.	Flavonoids	4-13	mitogen-activated protein kinase 8	Rattus norvegicus	55-58
16964755-8	2006	Among the compounds isolated from this plant, the five coumarins as well as the three flavonoids showed COX-2/5-LOX dual inhibitory activity.	Flavonoids	86-96	prostaglandin-endoperoxide synthase 2	Mus musculus	104-109
16964755-8	2006	Among the compounds isolated from this plant, the five coumarins as well as the three flavonoids showed COX-2/5-LOX dual inhibitory activity.	Flavonoids	86-96	arachidonate 5-lipoxygenase	Mus musculus	110-115
16964758-0	2006	Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.	Flavonoids	61-71	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-33
16964758-0	2006	Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.	Flavonoids	61-71	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-39
16964758-0	2006	Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.	Flavonoids	61-71	proprotein convertase subtilisin/kexin type 1	Homo sapiens	97-100
16964758-5	2006	At higher concentrations, most of the flavonoids demonstrated inhibition of AP-1 activity.	Flavonoids	38-48	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-80
16964758-7	2006	To determine the role of MAPK pathway in the induction of AP-1 by flavonoids, Western blot of phospho MAPK proteins was performed.	Flavonoids	66-76	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
16964758-9	2006	Induction of phospho-JNK and phospho-ERK activity was observed after two hour incubation of PC3-AP1 cells with flavonoids.	Flavonoids	111-121	mitogen-activated protein kinase 8	Homo sapiens	21-24
16964758-9	2006	Induction of phospho-JNK and phospho-ERK activity was observed after two hour incubation of PC3-AP1 cells with flavonoids.	Flavonoids	111-121	proprotein convertase subtilisin/kexin type 1	Homo sapiens	92-95
16832612-1	2006	PURPOSE: In this study, we chose three of the flavonoids isorhamnetin-3-O-rutinoside(IRR) diosmetin-7-O-beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranoside(DXG) and morin, which showed obvious efflux, to test the hypothesis that a specific efflux transporter is responsible for their transportation.	Flavonoids	46-56	insulin receptor related receptor	Homo sapiens	85-88
16829591-5	2006	We show that in the cop1-4 mutant, flavonoid accumulation and genome-wide expression changes in response to UV-B are blocked to a large extent.	Flavonoids	35-44	Proteasome component (PCI) domain protein	Arabidopsis thaliana	20-26
16494903-7	2006	Changes in phenolic content were associated with an increase in O-methyltransferase and C-glucosyltransferase activity toward flavonoid substrates as well as the classic enhancement of detoxifying glutathione transferases.	Flavonoids	126-135	omet	Triticum aestivum	64-83
16516478-7	2006	Some, but not all, of the data correlated with the binding of flavonoid derivatives to P-gp, and indicated that even in the P-gp highly expressing NCI/ADR-RES cells, the binding was not the only factor influencing the transport of [(14)C]paclitaxel.	Flavonoids	62-71	phosphoglycolate phosphatase	Homo sapiens	87-91
16455785-1	2006	Using mice deficient in hepatic cytochrome P-450 oxidoreductase (POR), which disables the liver cytochrome P-450 system, we examined the metabolism and biological response of the anticarcinogenic flavonoid, quercetin.	Flavonoids	196-205	cytochrome p450 oxidoreductase	Mus musculus	43-63
16455785-1	2006	Using mice deficient in hepatic cytochrome P-450 oxidoreductase (POR), which disables the liver cytochrome P-450 system, we examined the metabolism and biological response of the anticarcinogenic flavonoid, quercetin.	Flavonoids	196-205	cytochrome p450 oxidoreductase	Mus musculus	65-68
16902858-9	2006	This extract, which at low concentrations induces anti-inflammatory and analgesic effects in mouse models, presents a high content of flavonoids, known to inhibit inducible NOS (iNOS) activity.	Flavonoids	134-144	nitric oxide synthase 2, inducible	Mus musculus	163-176
16902858-9	2006	This extract, which at low concentrations induces anti-inflammatory and analgesic effects in mouse models, presents a high content of flavonoids, known to inhibit inducible NOS (iNOS) activity.	Flavonoids	134-144	nitric oxide synthase 2, inducible	Mus musculus	178-182
16516478-8	2006	Opposite effects of flavonoid derivatives on the P-gp highly expressing and MDA-MB-435 non-expressing cell lines indicate that paclitaxel is not only transported by P-gp and let us assume that Mrp2 or ABCC5 seem to be good transport-candidates in these cells.	Flavonoids	20-29	phosphoglycolate phosphatase	Homo sapiens	49-53
16516478-8	2006	Opposite effects of flavonoid derivatives on the P-gp highly expressing and MDA-MB-435 non-expressing cell lines indicate that paclitaxel is not only transported by P-gp and let us assume that Mrp2 or ABCC5 seem to be good transport-candidates in these cells.	Flavonoids	20-29	ATP binding cassette subfamily C member 2	Homo sapiens	193-197
16815818-0	2006	The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities.	Flavonoids	23-32	linoleate 9S-lipoxygenase-4	Glycine max	37-49
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Flavonoids	37-46	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16799064-7	2006	Finally, the ability of flavonoids to induce phase-2 detoxifying enzymes was tested by immunoblot analysis for the transcription factor Nrf2 and the phase-2 gene product heme-oxygenase 1.	Flavonoids	24-34	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
16456646-4	2006	Phenylalanine ammonia-lyase (PAL, EC 4.3.1.5) catalyzes the first and also a rate-limiting step in phenylpropanoid pathway, which supplies precursors for a variety of secondary metabolites including flavonoids.	Flavonoids	199-209	phenylalanine ammonia-lyase	Nicotiana tabacum	29-32
16799064-7	2006	Finally, the ability of flavonoids to induce phase-2 detoxifying enzymes was tested by immunoblot analysis for the transcription factor Nrf2 and the phase-2 gene product heme-oxygenase 1.	Flavonoids	24-34	heme oxygenase 1	Homo sapiens	170-186
16799064-13	2006	Many of these flavonoids induced the expression of Nrf2 and the phase-2 gene product heme-oxygenase 1 in human RPE cells.	Flavonoids	14-24	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
16799064-13	2006	Many of these flavonoids induced the expression of Nrf2 and the phase-2 gene product heme-oxygenase 1 in human RPE cells.	Flavonoids	14-24	heme oxygenase 1	Homo sapiens	85-101
16815818-0	2006	The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities.	Flavonoids	23-33	linoleate 9S-lipoxygenase-4	Glycine max	37-49
16891912-0	2006	Flavonoids from seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and eNOS expression.	Flavonoids	0-10	oxidized low density lipoprotein receptor 1	Homo sapiens	139-144
16891912-0	2006	Flavonoids from seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and eNOS expression.	Flavonoids	0-10	nitric oxide synthase 3	Homo sapiens	149-153
16810646-3	2006	Electrospray ionization quadrupole ion trap mass spectrometry with collision-induced dissociation (CID) was used to analyze complexes of the form [Co(II) (L-H) (Aux)]+ and [Co(II) (L-H) (Aux)2]+, in which L is the flavonoid glucuronide and Aux is a phenanthroline-based ligand.	Flavonoids	214-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-153
16456646-12	2006	These results indicate that PAL is maybe a key point for flux into flavonoid biosynthesis in the genetic control of secondary metabolism in A. membranaceus var.	Flavonoids	67-76	phenylalanine ammonia-lyase	Nicotiana tabacum	28-31
17010632-1	2006	Chalcone isomerase (CHI; EC 5.5.1.6) is a key enzyme in the flavonoid biosynthesis pathway.	Flavonoids	60-69	chalcone--flavanone isomerase	Nicotiana tabacum	20-23
17010632-8	2006	Transgenic tobacco plants with antisense SmCHI accumulated smaller amounts of flavonoids; this is apparently brought about by suppressed expression of the endogenous CHI gene.	Flavonoids	78-88	chalcone--flavanone isomerase	Nicotiana tabacum	43-46
16619332-7	2006	Flavonoids isolated from the plant leaves, produced a strong inhibitory effect on thrombin-induced platelet aggregation with an IC(50) of 0.25 +/- 0.05 and 0.40 +/- 0.04 mg/mL for genins and heterosidic flavonoids, respectively.	Flavonoids	0-10	coagulation factor II	Rattus norvegicus	82-90
17010632-9	2006	CHI activities also positively correlated with the amounts of total flavonoids accumulated in the transgenic plants.	Flavonoids	68-78	chalcone--flavanone isomerase	Nicotiana tabacum	0-3
16619332-7	2006	Flavonoids isolated from the plant leaves, produced a strong inhibitory effect on thrombin-induced platelet aggregation with an IC(50) of 0.25 +/- 0.05 and 0.40 +/- 0.04 mg/mL for genins and heterosidic flavonoids, respectively.	Flavonoids	203-213	coagulation factor II	Rattus norvegicus	82-90
16709193-0	2006	TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana.	Flavonoids	161-171	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-3
16639703-3	2006	The proposed method permits the identification of hop polyphenols (flavonoids glycosides and chalcones), bitter acids (alpha-acids and beta-acids), and their oxidation products.	Flavonoids	67-77	HOP homeobox	Homo sapiens	50-53
16702307-10	2006	Inhibition of VEGF release by flavonoids, tocopherols, and lovastatin in these models of neoplastic cells suggests a novel mechanism for mammary cancer prevention.	Flavonoids	30-40	vascular endothelial growth factor A	Homo sapiens	14-18
16794327-5	2006	HPLC analysis of the reaction products indicated that AtGT-2 transfers a glucose molecule into several different kinds of flavonoids, eriodictyol being the most effective substrate, followed by luteolin, kaempferol, and quercetin.	Flavonoids	122-132	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	54-60
16702307-0	2006	Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells.	Flavonoids	0-10	vascular endothelial growth factor A	Homo sapiens	70-104
16517757-4	2006	The enzyme activities of the SULT1A1 allozymes were studied with a variety of substrates, including PNP, 17beta-estradiol, 2-methoxyestradiol, catecholestrogens, the antiestrogen 4-hydroxytamoxifen (OHT), and dietary flavonoids.	Flavonoids	217-227	sulfotransferase family 1A member 1	Homo sapiens	29-36
16709193-0	2006	TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana.	Flavonoids	161-171	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	67-71
16709193-1	2006	The control of TT8 expression was investigated in this study, and it was demonstrated that it constitutes a major regulatory step in the specific activation of the expression of flavonoid structural genes.	Flavonoids	178-187	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	15-18
16584897-10	2006	These results indicated that cultured PGCs respond to exogenous agents on proliferation and that antioxidant flavonoids could restore the intracellular antioxidant system and promote PGC proliferation via their antioxidant action involving the PKA signaling pathway.	Flavonoids	109-119	progastricsin	Gallus gallus	38-41
16376383-0	2006	Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.	Flavonoids	34-44	aldo-keto reductase family 1, member C18	Mus musculus	48-84
16376383-7	2006	However, little is known about inhibitory effects of flavonoids on 20alpha-HSD activity.	Flavonoids	53-63	aldo-keto reductase family 1, member C18	Mus musculus	67-78
16376383-8	2006	Thus, the effects of 16 flavonoids on 20alpha-HSD activity were examined, using liver cytosol of male mice.	Flavonoids	24-34	aldo-keto reductase family 1, member C18	Mus musculus	38-49
16376383-9	2006	Among flavonoids tested, fisetin, apigenin, naringenin, luteolin, quercetin and kaempferol exhibited high inhibitory potencies for the 20alpha-HSD activity.	Flavonoids	6-16	aldo-keto reductase family 1, member C18	Mus musculus	135-146
16376383-10	2006	We propose the possibility that these flavonoids augment progesterone signaling by inhibiting potently 20alpha-HSD activity in non-reproductive tissues.	Flavonoids	38-48	aldo-keto reductase family 1, member C18	Mus musculus	103-114
16584897-7	2006	Flavonoids (1microg/ml) significantly promoted PGC proliferation, which could be markedly inhibited by ROS.	Flavonoids	0-10	progastricsin	Gallus gallus	47-50
16635738-5	2006	Flavonoids showed the strongest inhibitory effect on the expression of Cox-2 protein.	Flavonoids	0-10	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	71-76
16651438-0	2006	Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids.	Flavonoids	155-165	signal transducer and activator of transcription 3	Homo sapiens	33-83
16839212-3	2006	It has been reported that certain plant components such as flavonoids and indoles can affect AhR transformation.	Flavonoids	59-69	aryl hydrocarbon receptor	Rattus norvegicus	93-96
17147636-0	2006	Transgenic rice lines expressing maize C1 and R-S regulatory genes produce various flavonoids in the endosperm.	Flavonoids	83-93	anthocyanin regulatory C1 protein	Zea mays	39-49
16618767-0	2006	Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity.	Flavonoids	54-64	peroxiredoxin 5	Homo sapiens	24-45
16618767-3	2006	Here we have investigated the inhibition of mammalian TrxR by flavonoids which have been presumed to be cancer chemoprevention agents because of their antioxidant activities.	Flavonoids	62-72	peroxiredoxin 5	Homo sapiens	54-58
16619521-10	2006	CONCLUSION: Pharmacologically safe doses of the naturally occurring bioflavonoid Qu inhibit the PI3K-Akt/PKB pathway, in a manner similar to that of the commercially available LY.	Flavonoids	68-80	AKT serine/threonine kinase 1	Homo sapiens	101-104
16415120-6	2006	Moreover, flavonol glycosides and catechins significantly inhibited the function of OATP-B, suggesting that the inhibitory effects of the herbal extracts on OATP-B may be primarily attributable to flavonoids.	Flavonoids	197-207	solute carrier organic anion transporter family member 2B1	Homo sapiens	84-90
16415120-6	2006	Moreover, flavonol glycosides and catechins significantly inhibited the function of OATP-B, suggesting that the inhibitory effects of the herbal extracts on OATP-B may be primarily attributable to flavonoids.	Flavonoids	197-207	solute carrier organic anion transporter family member 2B1	Homo sapiens	157-163
16458870-4	2006	In our preliminary study, we investigated the effect of flavonoids including luteolin, quercetin, baicalein, genistein, taxifolin and catechin on HGF-mediated migration and invasion of HepG2 cells.	Flavonoids	56-66	hepatocyte growth factor	Homo sapiens	146-149
16280168-0	2006	Inhibition of interleukin-4 production in activated T cells via down-regulation of NF-AT DNA binding activity by apigenin, a flavonoid present in dietary plants.	Flavonoids	125-134	interleukin 4	Mus musculus	14-27
16303243-8	2006	BCRP transports sulfated estrogens but not free estrogens and in a series of screening experiments for synthesized and natural estrogenic compounds, several tamoxifen derivatives and phytoestrogens/flavonoids were identified that effectively circumvent BCRP-mediated drug resistance.	Flavonoids	198-208	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
16303243-8	2006	BCRP transports sulfated estrogens but not free estrogens and in a series of screening experiments for synthesized and natural estrogenic compounds, several tamoxifen derivatives and phytoestrogens/flavonoids were identified that effectively circumvent BCRP-mediated drug resistance.	Flavonoids	198-208	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	253-257
17075289-10	2006	Glucocorticoids and flavonoids inhibited MMP-9 production, and TIMPs and MMP inhibitors inhibited the gelatinolytic activity of mast cell-derived MMP-9.	Flavonoids	20-30	matrix metallopeptidase 9	Homo sapiens	41-46
16648565-0	2006	The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand.	Flavonoids	12-21	TNF superfamily member 10	Homo sapiens	67-122
16489132-5	2006	We examined the effect of ACC on tt4(2YY6) seedlings, which have a null mutation in the gene encoding chalcone synthase, the first enzyme in flavonoid synthesis.	Flavonoids	141-150	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	102-119
16619521-10	2006	CONCLUSION: Pharmacologically safe doses of the naturally occurring bioflavonoid Qu inhibit the PI3K-Akt/PKB pathway, in a manner similar to that of the commercially available LY.	Flavonoids	68-80	AKT serine/threonine kinase 1	Homo sapiens	105-108
16494971-0	2006	In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain.	Flavonoids	42-52	ATP binding cassette subfamily B member 1	Homo sapiens	64-78
16330143-14	2006	ACE inhibition by procyanidins in vivo might provide a mechanism to explain the benefits of flavonoid consumption on cardiovascular diseases.	Flavonoids	92-101	angiotensin I converting enzyme	Homo sapiens	0-3
16515531-6	2006	This review is focused at the modulatory effects of natural flavonoids on cell cycle regulators including cyclin-dependent kinases and their inhibitors, cyclins, p53, retinoblastoma family of proteins, E2Fs, check-point kinases, ATM/ATR and survivin controlling G1/S and G2/M check-point transitions in cell cycle progression, and discusses how these molecular changes could contribute to the antineoplastic effects of natural flavonoids.	Flavonoids	60-70	ATM serine/threonine kinase	Homo sapiens	229-232
16515531-6	2006	This review is focused at the modulatory effects of natural flavonoids on cell cycle regulators including cyclin-dependent kinases and their inhibitors, cyclins, p53, retinoblastoma family of proteins, E2Fs, check-point kinases, ATM/ATR and survivin controlling G1/S and G2/M check-point transitions in cell cycle progression, and discusses how these molecular changes could contribute to the antineoplastic effects of natural flavonoids.	Flavonoids	60-70	ATR serine/threonine kinase	Homo sapiens	233-236
16522772-0	2006	The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system.	Flavonoids	4-13	tumor necrosis factor	Homo sapiens	59-86
16522772-4	2006	We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) by human peripheral blood mononuclear cells (PBMC).	Flavonoids	75-84	tumor necrosis factor	Homo sapiens	202-229
16522772-4	2006	We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) by human peripheral blood mononuclear cells (PBMC).	Flavonoids	75-84	tumor necrosis factor	Homo sapiens	231-240
16484540-0	2006	Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells.	Flavonoids	24-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
16490770-8	2006	Screening of a library of 3523 natural products identified 11 compounds with high activity (&gt; or = 50% of FTC, confirmed by reassay), including 3 flavonoids, members of a family of compounds that include ABCG2 inhibitors.	Flavonoids	149-159	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	207-212
16465400-5	2006	Since MEC contains a variety of flavonoids, we selected nobiletin, hesperetin, and hesperidin (hesperetin glycoside) as representative compounds, and further evaluated these inhibitory activities.	Flavonoids	32-42	C-C motif chemokine ligand 28	Homo sapiens	6-9
16484540-0	2006	Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells.	Flavonoids	24-34	thymoma viral proto-oncogene 1	Mus musculus	96-99
16343431-1	2006	Flavonoids including luteolin, apigenin, and fisetin are inhibitors of IL-4 synthesis and CD40 ligand expression by basophils.	Flavonoids	0-10	interleukin 4	Homo sapiens	71-75
16289744-5	2006	This review focuses on the flavonoid effects on cytochrome P450 (CYP) enzymes involved in the activation of procarcinogens and phase II enzymes, largely responsible for the detoxification of carcinogens.	Flavonoids	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	48-63
16289744-5	2006	This review focuses on the flavonoid effects on cytochrome P450 (CYP) enzymes involved in the activation of procarcinogens and phase II enzymes, largely responsible for the detoxification of carcinogens.	Flavonoids	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-68
16289744-6	2006	A number of naturally occurring flavonoids have been shown to modulate the CYP450 system, including the induction of specific CYP isozymes, and the activation or inhibition of these enzymes.	Flavonoids	32-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-78
16289744-7	2006	Some flavonoids alter CYPs through binding to the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, acting as either AhR agonists or antagonists.	Flavonoids	5-15	aryl hydrocarbon receptor	Homo sapiens	50-75
16289744-7	2006	Some flavonoids alter CYPs through binding to the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, acting as either AhR agonists or antagonists.	Flavonoids	5-15	aryl hydrocarbon receptor	Homo sapiens	77-80
16289744-7	2006	Some flavonoids alter CYPs through binding to the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, acting as either AhR agonists or antagonists.	Flavonoids	5-15	aryl hydrocarbon receptor	Homo sapiens	141-144
16289744-10	2006	Activation of phase II detoxifying enzymes, such as UDP-glucuronyl transferase, glutathione S-transferase, and quinone reductase by flavonoids results in the detoxification of carcinogens and represents one mechanism of their anticarcinogenic effects.	Flavonoids	132-142	glutathione S-transferase kappa 1	Homo sapiens	80-105
16289744-11	2006	A number of flavonoids including fisetin, galangin, quercetin, kaempferol, and genistein represent potent non-competitive inhibitors of sulfotransferase 1A1 (or P-PST); this may represent an important mechanism for the chemoprevention of sulfation-induced carcinogenesis.	Flavonoids	12-22	sulfotransferase family 1A member 1	Homo sapiens	136-156
16289744-11	2006	A number of flavonoids including fisetin, galangin, quercetin, kaempferol, and genistein represent potent non-competitive inhibitors of sulfotransferase 1A1 (or P-PST); this may represent an important mechanism for the chemoprevention of sulfation-induced carcinogenesis.	Flavonoids	12-22	sulfotransferase family 1A member 1	Homo sapiens	161-166
16343431-2	2006	This study was done to search for compounds with greater inhibitory activity of IL-4 expression and to clarify the molecular mechanisms through which flavonoids inhibit their expression.	Flavonoids	150-160	interleukin 4	Homo sapiens	80-84
16343431-3	2006	Of the 37 flavonoids and related compounds examined, ayanin, luteolin, and apigenin were the strongest inhibitors of IL-4 production by purified basophils in response to anti-IgE antibody plus IL-3.	Flavonoids	10-20	interleukin 4	Homo sapiens	117-121
16343431-6	2006	These results provide a fundamental structure of flavonoids for IL-4 inhibition and demonstrate a novel action of flavonoids that suppresses the activation of AP-1.	Flavonoids	49-59	interleukin 4	Homo sapiens	64-68
16387852-0	2006	MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis.	Flavonoids	25-34	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	0-4
16543677-0	2006	Regulation of Cbfa1 expression by total flavonoids of Herba epimedii.	Flavonoids	40-50	RUNX family transcription factor 2	Rattus norvegicus	14-19
16168661-5	2006	The flavonoid quercetin inhibited Hsp27 induction and abrogated simvastatin-mediated neuroprotection.	Flavonoids	4-13	heat shock protein family B (small) member 1	Rattus norvegicus	34-39
16271822-0	2006	Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John"s wort.	Flavonoids	48-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-36
16271822-2	2006	In order to investigate whether flavonoids could specifically inhibit CYP 1B1, seven flavonoids in St. John"s wort and apigenin were screened for their inhibition of recombinant human CYP 1B1 and CYP 1A1.	Flavonoids	32-42	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	70-77
16271822-2	2006	In order to investigate whether flavonoids could specifically inhibit CYP 1B1, seven flavonoids in St. John"s wort and apigenin were screened for their inhibition of recombinant human CYP 1B1 and CYP 1A1.	Flavonoids	32-42	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	184-191
16271822-2	2006	In order to investigate whether flavonoids could specifically inhibit CYP 1B1, seven flavonoids in St. John"s wort and apigenin were screened for their inhibition of recombinant human CYP 1B1 and CYP 1A1.	Flavonoids	32-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	196-203
16271822-3	2006	While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP 1B1 EROD inhibition (K(i)s 0.06-5.96 microM) compared to CYP 1A1 (K(i)s 0.20-1.6 microM) the difference in K(i)s for the P450s were not significantly different.	Flavonoids	12-22	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	138-145
16271822-3	2006	While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP 1B1 EROD inhibition (K(i)s 0.06-5.96 microM) compared to CYP 1A1 (K(i)s 0.20-1.6 microM) the difference in K(i)s for the P450s were not significantly different.	Flavonoids	12-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	199-206
16271822-10	2006	Depending on their bioavailability, flavonoids that can selectively inhibit CYP1 enzymes may be useful as chemoprotective agents in prostate cancer prevention.	Flavonoids	36-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	76-80
16399234-3	2006	Herbal flavonoid isoliquiritigenin (ILTG) has previously been reported to be a strong suppresser of the COX-2 pathway as well as an inducer of apoptosis.	Flavonoids	7-16	prostaglandin-endoperoxide synthase 2	Mus musculus	104-109
16390204-1	2006	Angiotensin converting enzyme (ACE) activity was evaluated in the presence of flavanol-rich foods, i.e., wines, chocolates, and teas, and of purified flavonoids.	Flavonoids	150-160	angiotensin I converting enzyme	Rattus norvegicus	31-34
16387852-1	2006	We show that MAX1, a specific repressor of vegetative axillary bud outgrowth in Arabidopsis, acts a positive regulator of the flavonoid pathway, including 11 structural genes and the transcription factor An2.	Flavonoids	126-135	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	13-17
16387852-2	2006	Repression of bud outgrowth requires MAX1-dependent flavonoid gene expression.	Flavonoids	52-61	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	37-41
16387852-3	2006	As the flavonoidless state leads to lateral outgrowth in Arabidopsis, our data suggest that a flavonoid-based mechanism regulates axillary bud outgrowth and that this mechanism is under the control of MAX1.	Flavonoids	7-16	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	201-205
16387852-5	2006	We speculate that MAX1 could repress axillary bud outgrowth via regulating flavonoid-dependent auxin retention in the bud and underlying stem.	Flavonoids	75-84	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	18-22
16394499-2	2006	It has been revealed that flavonoids and other polyphenols inhibit P-gp activity.	Flavonoids	26-36	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
16316652-0	2006	Quercetin, a bioflavonoid, accelerates TNF-alpha-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells.	Flavonoids	13-25	tumor necrosis factor	Mus musculus	39-48
16325801-5	2006	Interestingly preincubation with the estrogen receptor alpha antagonist ICI 182,780 (1 microM) prior to kaempferol partially reverted the antiapoptotic effect of this flavonoid on caspase-3 activation and DNA fragmentation induced by 7beta-hydroxycholesterol.	Flavonoids	167-176	caspase 3	Rattus norvegicus	180-189
16569260-13	2006	The results suggest that this non-toxic bioflavonoid may be useful as a chemotherapeutic, particularly in combination with agents that target other components of the tumor cell cycle and in situations where estrogen receptor-specific therapeutics are ineffective.	Flavonoids	40-52	estrogen receptor 1	Homo sapiens	207-224
16317787-4	2006	Almost all flavonoids tested inhibited phosphorylated, active GPa, as well as unphosphorylated, adenosine monophosphate-activated GPb.	Flavonoids	11-21	glycophorin B (MNS blood group)	Homo sapiens	130-133
16611078-9	2006	12 flavonoids inhibit FAS with IC(50) values ranging from 2 to 112 microM.	Flavonoids	3-13	fatty acid synthase	Homo sapiens	22-25
17100629-0	2006	Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha.	Flavonoids	28-38	tumor necrosis factor	Mus musculus	93-120
17100629-3	2006	Here we describe new aspects of regulatory mechanisms by which flavonoids suppress production of tumor necrosis factor-alpha (TNF-alpha) by macrophages, microglial cells and mast cells stimulated with lipopolysaccharide (LPS) and others via toll-like receptors (TLRs), and TNF-alpha-mediated acute and chronic inflammatory responses.	Flavonoids	63-73	tumor necrosis factor	Mus musculus	97-124
17100629-3	2006	Here we describe new aspects of regulatory mechanisms by which flavonoids suppress production of tumor necrosis factor-alpha (TNF-alpha) by macrophages, microglial cells and mast cells stimulated with lipopolysaccharide (LPS) and others via toll-like receptors (TLRs), and TNF-alpha-mediated acute and chronic inflammatory responses.	Flavonoids	63-73	tumor necrosis factor	Mus musculus	126-135
17100629-3	2006	Here we describe new aspects of regulatory mechanisms by which flavonoids suppress production of tumor necrosis factor-alpha (TNF-alpha) by macrophages, microglial cells and mast cells stimulated with lipopolysaccharide (LPS) and others via toll-like receptors (TLRs), and TNF-alpha-mediated acute and chronic inflammatory responses.	Flavonoids	63-73	tumor necrosis factor	Mus musculus	273-282
17100629-4	2006	Treatment with flavonoids such as luteolin, apigenin, quercetin, genistein, (-)-epigallocatechin gallate, and anthocyanidin resulted in significant downregulation of LPS-elicited TNF-alpha and nitric oxide (NO) production and diminished lethal shock.	Flavonoids	15-25	tumor necrosis factor	Mus musculus	179-188
17100629-5	2006	In chronic diseases, pathogenesis of collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis which is triggered by TNF-alpha, was improved by the oral administration of flavonoids after the onset of CIA.	Flavonoids	185-195	tumor necrosis factor	Mus musculus	131-140
17100629-6	2006	Here, we discuss that inhibitory effects of flavonoids on acute and chronic inflammation are due to regulation of signaling pathways, including the nuclear factor kappaB (NF-kappaB) activation and mitogen-activated protein (MAP) kinase family phosphorylation.	Flavonoids	44-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-169
17100629-6	2006	Here, we discuss that inhibitory effects of flavonoids on acute and chronic inflammation are due to regulation of signaling pathways, including the nuclear factor kappaB (NF-kappaB) activation and mitogen-activated protein (MAP) kinase family phosphorylation.	Flavonoids	44-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	171-180
17100629-7	2006	FcetaRI expression by NF-kappaB activation was also reduced by flavonoids; while accumulation of lipid rafts, which is the critical step for signaling, was blocked by flavonoids.	Flavonoids	63-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-31
16601352-0	2006	Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils.	Flavonoids	12-21	CD40 molecule	Homo sapiens	32-36
16601352-1	2006	BACKGROUND: We have previously shown that flavonoids such as luteolin, apigenin and fisetin inhibit interleukin 4 and interleukin 13 production.	Flavonoids	42-52	interleukin 13	Homo sapiens	118-132
16601352-9	2006	Of the six flavonoids examined, luteolin, apigenin, fisetin and quercetin at 30 microM showed a significant inhibitory effect on CD40 ligand expression.	Flavonoids	11-21	CD40 molecule	Homo sapiens	129-133
16404131-0	2006	Regulation of lipoprotein lipase expression by effect of hawthorn flavonoids on peroxisome proliferator response element pathway.	Flavonoids	66-76	lipoprotein lipase	Mus musculus	14-32
16001171-3	2006	Furthermore in leukaemia cells some flavonoids cleave the breakpoint cluster region of the mixed lineage leukaemia (MLL) gene as a consequence of inhibition of topoisomerase II.	Flavonoids	36-46	lysine (K)-specific methyltransferase 2A	Mus musculus	116-119
16454693-7	2006	Certain dietary indoles and flavonoids activate CYP1A expression either by direct ligand interaction with the aryl hydrocarbon receptor (AhR) or by augmenting the interaction of the AhR with xenobiotic response elements in CYP1A1 and other target genes.	Flavonoids	28-38	aryl hydrocarbon receptor	Homo sapiens	110-135
16454693-7	2006	Certain dietary indoles and flavonoids activate CYP1A expression either by direct ligand interaction with the aryl hydrocarbon receptor (AhR) or by augmenting the interaction of the AhR with xenobiotic response elements in CYP1A1 and other target genes.	Flavonoids	28-38	aryl hydrocarbon receptor	Homo sapiens	137-140
16454693-7	2006	Certain dietary indoles and flavonoids activate CYP1A expression either by direct ligand interaction with the aryl hydrocarbon receptor (AhR) or by augmenting the interaction of the AhR with xenobiotic response elements in CYP1A1 and other target genes.	Flavonoids	28-38	aryl hydrocarbon receptor	Homo sapiens	182-185
16454693-7	2006	Certain dietary indoles and flavonoids activate CYP1A expression either by direct ligand interaction with the aryl hydrocarbon receptor (AhR) or by augmenting the interaction of the AhR with xenobiotic response elements in CYP1A1 and other target genes.	Flavonoids	28-38	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	223-229
16427799-8	2006	The two flavonoids also led to a decrease in the plasma and hepatic cholesterol levels that may have been partly due to the decreased hepatic 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase and acyl CoA: cholesterol acyltransferase (ACAT) activities and increased fecal cholesterol.	Flavonoids	8-18	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	179-197
16427799-8	2006	The two flavonoids also led to a decrease in the plasma and hepatic cholesterol levels that may have been partly due to the decreased hepatic 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase and acyl CoA: cholesterol acyltransferase (ACAT) activities and increased fecal cholesterol.	Flavonoids	8-18	sterol O-acyltransferase 2	Mus musculus	202-239
16427799-8	2006	The two flavonoids also led to a decrease in the plasma and hepatic cholesterol levels that may have been partly due to the decreased hepatic 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase and acyl CoA: cholesterol acyltransferase (ACAT) activities and increased fecal cholesterol.	Flavonoids	8-18	sterol O-acyltransferase 2	Mus musculus	241-245
16404131-5	2006	These results demonstrate that hawthorn flavonoids meditate LPL expression in mice with tissue-specific differences.	Flavonoids	40-50	lipoprotein lipase	Mus musculus	60-63
16367960-1	2006	Aureusidin synthase, a polyphenol oxidase (PPO), specifically catalyzes the oxidative formation of aurones from chalcones, which are plant flavonoids, and is responsible for the yellow coloration of snapdragon (Antirrhinum majus) flowers.	Flavonoids	139-149	type one serine/threonine protein phosphatase 2	Arabidopsis thaliana	43-46
16798551-11	2006	CFTR activators such as alkylxanthines (CPX) and the flavonoid genistein can overcome the affected ATP binding through direct binding to a nucleotide binding fold.	Flavonoids	53-62	CF transmembrane conductance regulator	Homo sapiens	0-4
16450301-4	2006	The most active flavonoid was jaceosidin that inhibited cyclooxygenase-2 activity in a concentration-dependent manner with an IC50 value of 2.8 microM.	Flavonoids	16-25	prostaglandin-endoperoxide synthase 2	Mus musculus	56-72
16450301-5	2006	In addition, the other flavonoids partially inhibited synovial phospholipase A2 activity.	Flavonoids	23-33	phospholipase A2, group IB, pancreas	Mus musculus	63-79
16327165-0	2005	Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells.	Flavonoids	62-72	ATP binding cassette subfamily B member 1	Homo sapiens	76-90
16314891-6	2006	We have screened a representative subgroup of 26 flavonoids for antiproliferative effect on the human PCa (LNCaP and PC3), breast cancer (MCF-7), and normal prostate stromal cell lines (PrSC).	Flavonoids	49-59	chromobox 8	Homo sapiens	117-120
16314891-10	2006	PC3 cells were arrested in G2/M phase by flavonoids.	Flavonoids	41-51	chromobox 8	Homo sapiens	0-3
16507512-1	2006	The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (P(e)) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.	Flavonoids	40-50	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	279-282
16507512-1	2006	The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (P(e)) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.	Flavonoids	40-50	ATP binding cassette subfamily B member 1	Homo sapiens	322-326
16601819-4	2005	We have tried to see whether inhibition of glutathione reductase (GR) can be influenced by preincubation of enzyme with NADPH (a creation of reduced form of enzyme, GRH(2)) and whether diaphorase activity of the enzyme is decreased by these flavonoids.	Flavonoids	241-251	glutathione-disulfide reductase	Homo sapiens	43-64
16507512-3	2006	Aglycone flavonoids reduced the P(e) of CSA to a greater extent than glycosylated flavonoids with 30 microM xanthohumol producing the greatest effect (7.2 x 10(-6) to 6.6 x 10(-7) and 17.9 x 10(-6) to 4.02 x 10(-6) cm s(-1) in Caco-2 and MDCKII-MDR1 cells, respectively); while no measurable effects were seen with digoxin.	Flavonoids	9-19	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	40-43
16507512-3	2006	Aglycone flavonoids reduced the P(e) of CSA to a greater extent than glycosylated flavonoids with 30 microM xanthohumol producing the greatest effect (7.2 x 10(-6) to 6.6 x 10(-7) and 17.9 x 10(-6) to 4.02 x 10(-6) cm s(-1) in Caco-2 and MDCKII-MDR1 cells, respectively); while no measurable effects were seen with digoxin.	Flavonoids	9-19	ATP binding cassette subfamily B member 1	Homo sapiens	245-249
16327165-5	2005	Therefore, the planar structure of the flavonoids seemed to be important for their interaction with P-gp.	Flavonoids	39-49	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
16327165-10	2005	These results suggested that hydrophobicity as well as planar structure is important for the inhibitory effects of flavonoids on P-gp-mediated transport.	Flavonoids	115-125	ATP binding cassette subfamily B member 1	Homo sapiens	129-133
16601819-4	2005	We have tried to see whether inhibition of glutathione reductase (GR) can be influenced by preincubation of enzyme with NADPH (a creation of reduced form of enzyme, GRH(2)) and whether diaphorase activity of the enzyme is decreased by these flavonoids.	Flavonoids	241-251	glutathione-disulfide reductase	Homo sapiens	66-68
16303981-8	2005	Several of the protective flavonoids also induced the synthesis of the transcription factor NF-E2-related factor 2 and phase 2 antioxidant enzymes such as heme oxygenase 1, markers for the activation of the antioxidant response element.	Flavonoids	26-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-114
16428296-5	2005	The inhibitory mechanism is the same as that of FAS flavonoid inhibitors.	Flavonoids	52-61	fatty acid synthase	Homo sapiens	48-51
16302800-4	2005	In addition, we screened a kinase targeted library and identified a number of high affinity inhibitors of PIM-1 such as imidazo[1,2-b]pyridazines, pyrazolo[1,5-a]pyrimidines, and members of the flavonoid family.	Flavonoids	194-203	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	106-111
16299170-7	2005	However, the observed phenotypes were correlated with the amount of total shoot anthocyanin at low temperature and with the transcription of the flavonoid pathway genes PAL1 and CHS.	Flavonoids	145-154	PHE ammonia lyase 1	Arabidopsis thaliana	169-173
16354411-0	2005	Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts.	Flavonoids	38-47	interleukin 1 beta	Homo sapiens	81-89
16226261-0	2005	Flavonoid components and flower color change in transgenic tobacco plants by suppression of chalcone isomerase gene.	Flavonoids	0-9	chalcone--flavanone isomerase	Nicotiana tabacum	92-110
16185736-2	2005	In this work, a PLA2 isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to study the effect of flavonoids on PLA2.	Flavonoids	137-147	phospholipase A2 group IB	Rattus norvegicus	16-20
16185736-2	2005	In this work, a PLA2 isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to study the effect of flavonoids on PLA2.	Flavonoids	137-147	phospholipase A2 group IB	Rattus norvegicus	151-155
16226261-1	2005	A cDNA encoding chalcone isomerase (CHI) was isolated from the petals of Nicotiana tabacum and the effect of its suppression on flavonoid biosynthesis was analyzed in transgenic tobacco plants.	Flavonoids	128-137	chalcone--flavanone isomerase	Nicotiana tabacum	16-34
16226261-1	2005	A cDNA encoding chalcone isomerase (CHI) was isolated from the petals of Nicotiana tabacum and the effect of its suppression on flavonoid biosynthesis was analyzed in transgenic tobacco plants.	Flavonoids	128-137	chalcone--flavanone isomerase	Nicotiana tabacum	36-39
16388471-4	2005	In this study, a set of experiments was performed to elucidate the effect of N nutrition on the activities of key enzymes involved in flavonoid biosynthesis (phenylalanine ammonia-lyase [PAL], chalcone synthase/chalcone isomerase [CHS/CHI}, flavanone 3-hydroxylase [FHT], flavonol synthase [FLS], dihydroflavonol 4-reductase [DFR]) and the accumulation of different groups of phenylpropanoids.	Flavonoids	134-143	naringenin,2-oxoglutarate 3-dioxygenase	Malus domestica	266-269
16220062-0	2005	Bioflavonoids effectively inhibit smooth muscle cell-mediated contraction of collagen matrix induced by angiotensin II.	Flavonoids	0-13	angiotensinogen	Homo sapiens	104-118
16220062-10	2005	Bioflavonoid inhibition of collagen gel contraction by SMC correlated with inhibition of matrix metalloproteinase-2 expression.	Flavonoids	0-12	matrix metallopeptidase 2	Homo sapiens	89-115
16320211-0	2005	Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor.	Flavonoids	11-21	estrogen receptor 1	Rattus norvegicus	65-82
16081670-0	2005	Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators.	Flavonoids	0-10	solute carrier organic anion transporter family member 1B1	Homo sapiens	76-83
16081670-0	2005	Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators.	Flavonoids	0-10	solute carrier organic anion transporter family member 1B1	Homo sapiens	85-91
16081670-2	2005	The interactions of flavonoids with some major efflux transporters [e.g., P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein] have been reported; however, their interactions with uptake transporters are largely unknown.	Flavonoids	20-30	ATP binding cassette subfamily C member 1	Homo sapiens	90-131
16081670-2	2005	The interactions of flavonoids with some major efflux transporters [e.g., P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein] have been reported; however, their interactions with uptake transporters are largely unknown.	Flavonoids	20-30	ATP binding cassette subfamily C member 1	Homo sapiens	133-137
16081670-2	2005	The interactions of flavonoids with some major efflux transporters [e.g., P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein] have been reported; however, their interactions with uptake transporters are largely unknown.	Flavonoids	20-30	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-176
16081670-4	2005	Our objective was to evaluate the effects of 20 naturally occurring flavonoids, and some of their corresponding glycosides, on the uptake of [3H]dehydroepiandrosterone sulfate (DHEAS) in OATP1B1-expressing and OATP1B1-negative HeLa cells.	Flavonoids	68-78	solute carrier organic anion transporter family member 1B1	Homo sapiens	187-194
16081670-4	2005	Our objective was to evaluate the effects of 20 naturally occurring flavonoids, and some of their corresponding glycosides, on the uptake of [3H]dehydroepiandrosterone sulfate (DHEAS) in OATP1B1-expressing and OATP1B1-negative HeLa cells.	Flavonoids	68-78	solute carrier organic anion transporter family member 1B1	Homo sapiens	210-217
16081670-5	2005	Many of the tested flavonoids (including biochanin A, genistein, and epigallocatechin-3-gallate) significantly inhibited [3H]DHEAS uptake in a concentration-dependent manner in OATP1B1-expressing cells, with biochanin A being one of the most potent inhibitors with an IC50 of 11.3 +/- 3.22 microM.	Flavonoids	19-29	solute carrier organic anion transporter family member 1B1	Homo sapiens	177-184
16081670-6	2005	The flavonoids had negligible or small effects in OATP1B1-negative cells.	Flavonoids	4-14	solute carrier organic anion transporter family member 1B1	Homo sapiens	50-57
16081670-11	2005	Taken together, these results indicate that flavonoids are a novel class of OATP1B1 modulators, suggesting the potential for diet-drug interactions.	Flavonoids	44-54	solute carrier organic anion transporter family member 1B1	Homo sapiens	76-83
16266898-1	2005	BACKGROUND AND OBJECTIVES: The enzyme NAD(P)H:quinone oxidoreductase (NQO1) detoxifies chemicals with quinone rings including benzene metabolites and flavonoids.	Flavonoids	150-160	crystallin zeta	Homo sapiens	46-68
16266898-1	2005	BACKGROUND AND OBJECTIVES: The enzyme NAD(P)H:quinone oxidoreductase (NQO1) detoxifies chemicals with quinone rings including benzene metabolites and flavonoids.	Flavonoids	150-160	NAD(P)H quinone dehydrogenase 1	Homo sapiens	70-74
16243908-0	2005	TRANSPARENT TESTA10 encodes a laccase-like enzyme involved in oxidative polymerization of flavonoids in Arabidopsis seed coat.	Flavonoids	90-100	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	12-19
16243908-11	2005	Together, these data establish that TT10 is involved in the oxidative polymerization of flavonoids and functions as a laccase-type flavonoid oxidase.	Flavonoids	88-98	Laccase/Diphenol oxidase family protein	Arabidopsis thaliana	36-40
16388471-4	2005	In this study, a set of experiments was performed to elucidate the effect of N nutrition on the activities of key enzymes involved in flavonoid biosynthesis (phenylalanine ammonia-lyase [PAL], chalcone synthase/chalcone isomerase [CHS/CHI}, flavanone 3-hydroxylase [FHT], flavonol synthase [FLS], dihydroflavonol 4-reductase [DFR]) and the accumulation of different groups of phenylpropanoids.	Flavonoids	134-143	flavonol synthase/flavanone 3-hydroxylase	Malus domestica	272-289
16388471-4	2005	In this study, a set of experiments was performed to elucidate the effect of N nutrition on the activities of key enzymes involved in flavonoid biosynthesis (phenylalanine ammonia-lyase [PAL], chalcone synthase/chalcone isomerase [CHS/CHI}, flavanone 3-hydroxylase [FHT], flavonol synthase [FLS], dihydroflavonol 4-reductase [DFR]) and the accumulation of different groups of phenylpropanoids.	Flavonoids	134-143	flavonol synthase/flavanone 3-hydroxylase	Malus domestica	291-294
16388471-4	2005	In this study, a set of experiments was performed to elucidate the effect of N nutrition on the activities of key enzymes involved in flavonoid biosynthesis (phenylalanine ammonia-lyase [PAL], chalcone synthase/chalcone isomerase [CHS/CHI}, flavanone 3-hydroxylase [FHT], flavonol synthase [FLS], dihydroflavonol 4-reductase [DFR]) and the accumulation of different groups of phenylpropanoids.	Flavonoids	134-143	bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase	Malus domestica	297-324
16388471-4	2005	In this study, a set of experiments was performed to elucidate the effect of N nutrition on the activities of key enzymes involved in flavonoid biosynthesis (phenylalanine ammonia-lyase [PAL], chalcone synthase/chalcone isomerase [CHS/CHI}, flavanone 3-hydroxylase [FHT], flavonol synthase [FLS], dihydroflavonol 4-reductase [DFR]) and the accumulation of different groups of phenylpropanoids.	Flavonoids	134-143	bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase	Malus domestica	326-329
15905203-10	2005	Methoxylated dietary flavonoids, e.g. DMF and 3",4"-DMF, may be potent chemoprotectants by direct inhibition of CYP1B1/1A1 function and/or their protein expression.	Flavonoids	21-31	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	112-118
16276964-2	2005	In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase.	Flavonoids	88-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	108-131
16276964-2	2005	In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase.	Flavonoids	88-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	326-332
16276964-2	2005	In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase.	Flavonoids	88-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	334-340
16276964-2	2005	In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase.	Flavonoids	88-98	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	345-351
16276964-2	2005	In order to determine the effects of the number of hydroxyl groups in the B-ring of the flavonoids on human cytochrome P450 (CYP) 1 family enzymes, we evaluated the inhibition of CYP1A-dependent 7-ethoxyresorufin omicron-deethylation activity by chrysin, apigenin and luteolin, using bacterial membranes that co-express human CYP1A1, CYP1A2, or CYP1B1 with human NADPH-cytochrome P450 reductase.	Flavonoids	88-98	cytochrome p450 oxidoreductase	Homo sapiens	363-394
15905203-10	2005	Methoxylated dietary flavonoids, e.g. DMF and 3",4"-DMF, may be potent chemoprotectants by direct inhibition of CYP1B1/1A1 function and/or their protein expression.	Flavonoids	21-31	solute carrier family 45 member 2	Homo sapiens	119-122
16037419-1	2005	In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase (DNMT) and human DNMT1.	Flavonoids	93-106	DNA methyltransferase 1	Homo sapiens	156-177
16177189-0	2005	Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia.	Flavonoids	14-24	CF transmembrane conductance regulator	Homo sapiens	33-37
16177189-2	2005	In this study, the dose-dependent effects of flavonoid compounds present in cocoa, or molecularly closely related compounds, were tested on forskolin-stimulated cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl- secretion across T84 colonic epithelia in Ussing chambers.	Flavonoids	45-54	CF transmembrane conductance regulator	Homo sapiens	214-218
16037419-1	2005	In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase (DNMT) and human DNMT1.	Flavonoids	93-106	DNA methyltransferase 1	Homo sapiens	179-183
16037419-1	2005	In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase (DNMT) and human DNMT1.	Flavonoids	93-106	DNA methyltransferase 1	Homo sapiens	195-200
16109301-7	2005	Quercetin (10--40 microM), also a flavonoid, also inhibited hemin-induced HO-1 expression.	Flavonoids	34-43	heme oxygenase 1	Mus musculus	74-78
16254825-2	2005	The effect of these flavonoids on stimulus-induced superoxide generation in human neutrophils was assayed by measuring the reduction of cytochrome c.	Flavonoids	20-30	cytochrome c, somatic	Homo sapiens	136-148
16261515-0	2005	Evaluation of flavonoids from Bauhinia megalandra leaves as inhibitors of glucose-6-phosphatase system.	Flavonoids	14-24	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	74-95
16261515-1	2005	From the methanol extract of Bauhinia megalandra fresh leaves, eight flavonoids were isolated and evaluated by rat liver microsomal glucose-6-phosphatase (G-6-Pase) bioassay, which might be a useful methodology for screening antihyperglycaemic substances.	Flavonoids	69-79	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	132-153
16261515-1	2005	From the methanol extract of Bauhinia megalandra fresh leaves, eight flavonoids were isolated and evaluated by rat liver microsomal glucose-6-phosphatase (G-6-Pase) bioassay, which might be a useful methodology for screening antihyperglycaemic substances.	Flavonoids	69-79	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	155-163
16261515-2	2005	All the flavonoids assayed showed an inhibitory effect on the intact microsomal G-6-Pase: quercetin and kaempferol exhibited the lowest effect; astilbin, quercetin 3-O-alpha-rhamnoside, kaempferol 3-O-alpha-rhamnoside and quercetin 3-O-alpha-arabinoside an intermediate effect.	Flavonoids	8-18	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	80-88
16335816-4	2005	Flavonoid compounds and their derivates from traditional medicinal herbs are active inhibitors to aldose reductase, such as quercetin, silymarin, puerarin, baicalim, berberine and so on.	Flavonoids	0-9	aldo-keto reductase family 1 member B	Homo sapiens	98-114
16109301-9	2005	These results suggest that hemin-induced HO-1 expression can be attenuated by flavonoids, such as APG.	Flavonoids	78-88	heme oxygenase 1	Mus musculus	41-45
16156793-10	2005	Collectively, these results suggest that dietary flavonoids such as quercetin and silymarin can modulate transport activities of MRP1, -4 and -5.	Flavonoids	49-59	ATP binding cassette subfamily C member 1	Homo sapiens	129-144
16106293-11	2005	Thus, by utilising flavonoid substrates with different C-2 stereochemistries, the balance between C-3 hydroxylation or C-2, C-3 desaturation mechanisms can be altered.	Flavonoids	19-28	complement C2	Homo sapiens	55-58
16106293-11	2005	Thus, by utilising flavonoid substrates with different C-2 stereochemistries, the balance between C-3 hydroxylation or C-2, C-3 desaturation mechanisms can be altered.	Flavonoids	19-28	complement C3	Homo sapiens	98-101
16106293-11	2005	Thus, by utilising flavonoid substrates with different C-2 stereochemistries, the balance between C-3 hydroxylation or C-2, C-3 desaturation mechanisms can be altered.	Flavonoids	19-28	complement C2	Homo sapiens	119-122
16106293-11	2005	Thus, by utilising flavonoid substrates with different C-2 stereochemistries, the balance between C-3 hydroxylation or C-2, C-3 desaturation mechanisms can be altered.	Flavonoids	19-28	complement C3	Homo sapiens	124-127
16014620-0	2005	Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids.	Flavonoids	103-113	mitogen-activated protein kinase 1	Homo sapiens	78-81
16014620-8	2005	Taken together, our data clearly indicate that a host of phytochemicals, including etoposide and a variety of flavonoids, differentially regulate the apoptosis of human HaCaT keratinocytes via the differential modulation of intracellular ROS production, coupled with the concomitant activation of the ERK signaling pathway.	Flavonoids	110-120	mitogen-activated protein kinase 1	Homo sapiens	301-304
16194866-7	2005	After warming, platelets that were chilled in the presence of flavonoids retain a normal shape change and aggregation response after stimulation by thrombin.	Flavonoids	62-72	coagulation factor II, thrombin	Homo sapiens	148-156
15880796-11	2005	CFTR activators such as alkylxanthines (CPX) and the flavonoid genistein can overcome affected ATP binding through direct binding to a nucleotide binding fold.	Flavonoids	53-62	CF transmembrane conductance regulator	Homo sapiens	0-4
15916776-0	2005	Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.	Flavonoids	74-84	ATP binding cassette subfamily C member 1	Homo sapiens	14-18
15916776-1	2005	The influence of novel synthetic and plant origin flavonoids on activity of multidrug resistance-associated protein (MRP1) was investigated in human erythrocytes used as a cell model expressing MRP1 in plasma membrane.	Flavonoids	50-60	ATP binding cassette subfamily C member 1	Homo sapiens	76-121
15916776-1	2005	The influence of novel synthetic and plant origin flavonoids on activity of multidrug resistance-associated protein (MRP1) was investigated in human erythrocytes used as a cell model expressing MRP1 in plasma membrane.	Flavonoids	50-60	ATP binding cassette subfamily C member 1	Homo sapiens	117-121
15916776-4	2005	Most of the flavonoids showed strong or moderate ability to inhibit transport carried out by MRP1.	Flavonoids	12-22	ATP binding cassette subfamily C member 1	Homo sapiens	93-97
15963948-3	2005	Our previous studies have shown that luteolin, a naturally occurring flavonoid, induces the up-regulation of death receptor 5 (DR5), which is a receptor for TRAIL.	Flavonoids	69-78	TNF receptor superfamily member 10b	Homo sapiens	109-125
15979586-0	2005	Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein.	Flavonoids	91-100	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	124-156
15979586-2	2005	Flavonoids, a major class of natural compounds widely present in foods and herbal products, have been shown to be BCRP inhibitors.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	114-118
15979586-3	2005	The objective of the present study was to elucidate the SAR and derive a QSAR model for flavonoid-BCRP interaction.	Flavonoids	88-97	sarcosine dehydrogenase	Homo sapiens	56-59
15979586-3	2005	The objective of the present study was to elucidate the SAR and derive a QSAR model for flavonoid-BCRP interaction.	Flavonoids	88-97	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	98-102
15979586-5	2005	Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport.	Flavonoids	29-39	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	43-75
15979586-5	2005	Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport.	Flavonoids	29-39	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	77-82
15979586-8	2005	These structural requirements are similar but not identical to those for potent flavonoid-NBD2 (P-glycoprotein) interaction, indicating that inhibition of BCRP by flavonoids may involve, in part, the binding of flavonoids with the NBD of BCRP.	Flavonoids	80-89	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	155-159
15979586-8	2005	These structural requirements are similar but not identical to those for potent flavonoid-NBD2 (P-glycoprotein) interaction, indicating that inhibition of BCRP by flavonoids may involve, in part, the binding of flavonoids with the NBD of BCRP.	Flavonoids	163-173	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	155-159
15979586-8	2005	These structural requirements are similar but not identical to those for potent flavonoid-NBD2 (P-glycoprotein) interaction, indicating that inhibition of BCRP by flavonoids may involve, in part, the binding of flavonoids with the NBD of BCRP.	Flavonoids	163-173	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	238-242
15979586-8	2005	These structural requirements are similar but not identical to those for potent flavonoid-NBD2 (P-glycoprotein) interaction, indicating that inhibition of BCRP by flavonoids may involve, in part, the binding of flavonoids with the NBD of BCRP.	Flavonoids	211-221	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	155-159
15979586-8	2005	These structural requirements are similar but not identical to those for potent flavonoid-NBD2 (P-glycoprotein) interaction, indicating that inhibition of BCRP by flavonoids may involve, in part, the binding of flavonoids with the NBD of BCRP.	Flavonoids	211-221	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	238-242
15979586-9	2005	In addition, a QSAR model consisting three structural descriptors was constructed, and both internally and externally validated, suggesting the model could be used to quantitatively predict BCRP inhibition activity of flavonoids.	Flavonoids	218-228	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	190-194
15979586-10	2005	These findings should be useful for predicting BCRP inhibition activity of other untested flavonoids and for guiding the synthesis of potent BCRP inhibitors for potential clinical application.	Flavonoids	90-100	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-51
15890477-2	2005	Many XME are regulated via aryl hydrocarbon receptor (AhR)-dependent pathways, and numerous naturally occurring AhR agonists (e.g. flavonoids, dietary indoles) have been identified to date.	Flavonoids	131-141	aryl hydrocarbon receptor	Homo sapiens	112-115
15963948-3	2005	Our previous studies have shown that luteolin, a naturally occurring flavonoid, induces the up-regulation of death receptor 5 (DR5), which is a receptor for TRAIL.	Flavonoids	69-78	TNF receptor superfamily member 10b	Homo sapiens	127-130
15963948-3	2005	Our previous studies have shown that luteolin, a naturally occurring flavonoid, induces the up-regulation of death receptor 5 (DR5), which is a receptor for TRAIL.	Flavonoids	69-78	TNF superfamily member 10	Homo sapiens	157-162
15946653-3	2005	Previously, we demonstrated that in vitro flavonoids, including luteolin and apigenin, inhibit proliferation and IFN-gamma production by murine and human autoimmune T cells.	Flavonoids	42-52	interferon gamma	Mus musculus	113-122
16108826-3	2005	Furthermore, synthetic estrogens, tamoxifen derivatives and phytoestrogens/flavonoids have now been identified that can effectively circumvent BCRP-mediated drug resistance.	Flavonoids	75-85	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	143-147
16094442-5	2005	We isolated 4 partial nucleotide sequences of the early flavonoid biosynthesis genes (CHS, CHI, F3H, and DFR) in wheat.	Flavonoids	56-65	DFR	Triticum aestivum	96-108
16142647-1	2005	Prenylated flavonoids isolated from Erythrina senegalensis were evaluated for their ability to inhibit PLCgamma1 activity in vitro and the formation of inositol phosphates (IPt) in PLCgamma1-overexpressing NIH3T3 fibroblast cells (NIH3T3gamma1 cells).	Flavonoids	11-21	phospholipase C, gamma 1	Mus musculus	103-112
16142647-1	2005	Prenylated flavonoids isolated from Erythrina senegalensis were evaluated for their ability to inhibit PLCgamma1 activity in vitro and the formation of inositol phosphates (IPt) in PLCgamma1-overexpressing NIH3T3 fibroblast cells (NIH3T3gamma1 cells).	Flavonoids	11-21	phospholipase C, gamma 1	Mus musculus	181-190
16142647-2	2005	These flavonoids inhibited PLCgamma1 activity in a dose-dependent manner (IC (50) values ranged from 1.0 microg/mL to 35.0 microg/mL) with the exception of alpinumisoflavone ( 5).	Flavonoids	6-16	phospholipase C, gamma 1	Mus musculus	27-36
15914008-1	2005	Theoretical descriptors obtained from quantum mechanical calculations on isolated ligands in different media and molecular dynamics simulations of ligand-enzyme complexes have been used to obtain a quantitative rationalization of the inhibition of CYP1A2 and CYP1A2 by three series of flavonoids.	Flavonoids	285-295	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	248-254
15914008-1	2005	Theoretical descriptors obtained from quantum mechanical calculations on isolated ligands in different media and molecular dynamics simulations of ligand-enzyme complexes have been used to obtain a quantitative rationalization of the inhibition of CYP1A2 and CYP1A2 by three series of flavonoids.	Flavonoids	285-295	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	259-265
15946653-5	2005	Continuous oral administration of flavonoids significantly affected antigen-specific proliferation and IFN-gamma production by lymph node-derived T cells following immunization with an EAE-inducing peptide.	Flavonoids	34-44	interferon gamma	Mus musculus	103-112
15946653-7	2005	Other flavonoids exerted differential effects on proliferation and IFN-gamma production.	Flavonoids	6-16	interferon gamma	Mus musculus	67-76
16000722-2	2005	beta-Glucuronidase activity plays a major role in the generation of toxic and carcinogenic metabolites in the large intestine, as well as in the absorption and enterohepatic circulation of many aglycone residues with protective effects, such as lignans, flavonoids, ceramide and glycyrrhetinic acid, that are liberated by the hydrolysis of the corresponding glucuronides.	Flavonoids	254-264	glucuronidase beta	Homo sapiens	0-18
16114498-10	2005	These results suggest that some flavonoids such as biochanin A and silymarin may reverse MDR by inhibiting the P-gp function.	Flavonoids	32-42	ATP binding cassette subfamily B member 1	Homo sapiens	111-115
15946255-0	2005	The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells.	Flavonoids	4-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-68
16789892-2	2005	Anti-cancer properties have long been associated with flavonoids, and some compounds of this class have been shown to interact directly with CYP1A2.	Flavonoids	54-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	141-147
15964517-0	2005	Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells.	Flavonoids	51-61	crystallin zeta	Homo sapiens	14-36
15964517-2	2005	This paper presents the effects of flavonoids on NAD(P)H:quinone oxidoreductase 1 (NQO1) activity, by a newly developed method to measure NQO1 inhibition in intact cells.	Flavonoids	35-45	NAD(P)H quinone dehydrogenase 1	Homo sapiens	49-81
15964517-2	2005	This paper presents the effects of flavonoids on NAD(P)H:quinone oxidoreductase 1 (NQO1) activity, by a newly developed method to measure NQO1 inhibition in intact cells.	Flavonoids	35-45	NAD(P)H quinone dehydrogenase 1	Homo sapiens	83-87
15964517-2	2005	This paper presents the effects of flavonoids on NAD(P)H:quinone oxidoreductase 1 (NQO1) activity, by a newly developed method to measure NQO1 inhibition in intact cells.	Flavonoids	35-45	NAD(P)H quinone dehydrogenase 1	Homo sapiens	138-142
15964517-8	2005	For the first time, we determined NQO1 inhibition by flavonoids in cells without disruption of the cells or addition of cofactors, enabling the assessment of enzymatic activity and the interaction of modulators of enzymatic activity in an intracellular situation.	Flavonoids	53-63	NAD(P)H quinone dehydrogenase 1	Homo sapiens	34-38
15951803-0	2005	Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes.	Flavonoids	73-82	DET1 partner of COP1 E3 ubiquitin ligase	Homo sapiens	44-48
15896345-8	2005	Thus, the present study demonstrates the ability of the flavonoid myricetin to modulate MRP1 and MRP2 mediated resistance to the anticancer drug vincristine in transfected cells, indicating that flavonoids might be a valuable adjunct to chemotherapy to block MRP mediated resistance.	Flavonoids	56-65	ATP binding cassette subfamily C member 1	Canis lupus familiaris	88-92
16161024-0	2005	Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae.	Flavonoids	66-76	CTX-M-15	Klebsiella pneumoniae	94-126
16161024-0	2005	Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae.	Flavonoids	66-76	CTX-M-15	Klebsiella pneumoniae	128-132
16161024-7	2005	Because of the low-toxic nature of flavonoids, the combination of antibiotics and flavonoids is a potential new strategy for developing therapies for infections caused by ESBL-producing bacteria in the future.	Flavonoids	35-45	CTX-M-15	Klebsiella pneumoniae	171-175
16161024-7	2005	Because of the low-toxic nature of flavonoids, the combination of antibiotics and flavonoids is a potential new strategy for developing therapies for infections caused by ESBL-producing bacteria in the future.	Flavonoids	82-92	CTX-M-15	Klebsiella pneumoniae	171-175
16201455-1	2005	The purpose of the present study was to quantify the antihypertensive effect of the total flavonoid (TF), extracted from the seed of Astragalus complanatus R. Brown, and to observe its effect on the renin-angiotensin system (RAS) in both renal hypertensive rats (RHR) and spontaneously hypertensive rats (SHR).	Flavonoids	90-99	renin	Rattus norvegicus	199-204
15896345-8	2005	Thus, the present study demonstrates the ability of the flavonoid myricetin to modulate MRP1 and MRP2 mediated resistance to the anticancer drug vincristine in transfected cells, indicating that flavonoids might be a valuable adjunct to chemotherapy to block MRP mediated resistance.	Flavonoids	56-65	ATP binding cassette subfamily C member 2	Canis lupus familiaris	97-101
15896345-8	2005	Thus, the present study demonstrates the ability of the flavonoid myricetin to modulate MRP1 and MRP2 mediated resistance to the anticancer drug vincristine in transfected cells, indicating that flavonoids might be a valuable adjunct to chemotherapy to block MRP mediated resistance.	Flavonoids	195-205	ATP binding cassette subfamily C member 1	Canis lupus familiaris	88-92
15896345-8	2005	Thus, the present study demonstrates the ability of the flavonoid myricetin to modulate MRP1 and MRP2 mediated resistance to the anticancer drug vincristine in transfected cells, indicating that flavonoids might be a valuable adjunct to chemotherapy to block MRP mediated resistance.	Flavonoids	195-205	ATP binding cassette subfamily C member 2	Canis lupus familiaris	97-101
15911222-0	2005	Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?	Flavonoids	41-51	phosphoglycolate phosphatase	Homo sapiens	68-80
15930306-0	2005	Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.	Flavonoids	0-9	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	149-154
15930306-2	2005	The GF120918-sensitive drug efflux activity of human wild-type (R482) ABCG2-transfected cells was used for rational screening of inhibitory flavonoids and establishment of structure-activity relationships.	Flavonoids	140-150	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	70-75
15919788-0	2005	Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes.	Flavonoids	114-123	microsomal triglyceride transfer protein	Homo sapiens	14-54
15919788-0	2005	Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes.	Flavonoids	114-123	apolipoprotein B	Homo sapiens	70-89
15919788-2	2005	The citrus flavonoid naringenin, like insulin, decreased MTP expression in HepG2 cells, resulting in inhibition of apoB100 secretion; however, the mechanism for naringenin is independent of insulin receptor substrate-1/2.	Flavonoids	11-20	microsomal triglyceride transfer protein	Homo sapiens	57-60
15919788-2	2005	The citrus flavonoid naringenin, like insulin, decreased MTP expression in HepG2 cells, resulting in inhibition of apoB100 secretion; however, the mechanism for naringenin is independent of insulin receptor substrate-1/2.	Flavonoids	11-20	apolipoprotein B	Homo sapiens	115-122
15911222-3	2005	To elucidate the mechanism behind the interaction observed in this system the potency of the flavonoids to replace [3H]talinolol from its P-gp binding site as well as their activity to inhibit OCT2-mediated [14C]TEA uptake into LLC-PK(1) cells were measured, as P-gp and OCT have been shown to be present in Caco-2 cells.	Flavonoids	93-103	phosphoglycolate phosphatase	Homo sapiens	138-142
15911222-6	2005	However, the investigated flavonoids did show potency to inhibit OCT-mediated transport (IC50-values: quercetin&lt;kaempferol&lt;&lt;naringenin&lt;isoquercitrin&lt;spiraeoside&lt;&lt;rutin&lt;hesperetin&lt;naringin).	Flavonoids	26-36	plexin A2	Homo sapiens	65-68
15809162-0	2005	Quantitative structure-activity relationship to predict differential inhibition of aldose reductase by flavonoid compounds.	Flavonoids	103-112	aldo-keto reductase family 1 member B	Homo sapiens	83-99
15930438-1	2005	We investigated whether different concentrations of the flavonoid quercetin ameliorate nitric oxide production and nuclear factor (NF)-kappaB activation in interleukin (IL)-1beta-activated rat hepatocytes.	Flavonoids	56-65	interleukin 1 beta	Rattus norvegicus	156-178
15884859-0	2005	Covalent binding of the flavonoid quercetin to human serum albumin.	Flavonoids	24-33	albumin	Homo sapiens	53-66
16922649-2	2005	The AhR can be activated by a wide range of classes of compounds (e.g. polycyclic aromatic hydrocarbons, benzimidazoles and flavonoids), and interacts with a number of other proteins, including nuclear hormone receptors such as the oestrogen and androgen receptors.	Flavonoids	124-134	aryl hydrocarbon receptor	Homo sapiens	4-7
16007460-0	2005	Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation.	Flavonoids	50-59	potassium voltage-gated channel subfamily H member 2	Homo sapiens	22-26
16007460-2	2005	In a previous study, we demonstrated for the first time that flavonoids are inhibitors of cardiac human ether-a-go-go-related gene (HERG) channels.	Flavonoids	61-71	potassium voltage-gated channel subfamily H member 2	Homo sapiens	132-136
16007460-4	2005	HERG blockade by grapefruit flavonoid naringenin is most likely to be the mechanism underlying this effect.	Flavonoids	28-37	potassium voltage-gated channel subfamily H member 2	Homo sapiens	0-4
15923334-2	2005	Here, we identified the Arabidopsis (Arabidopsis thaliana) R2R3-MYB transcription factor MYB12 as a flavonol-specific activator of flavonoid biosynthesis.	Flavonoids	131-140	myb domain protein 12	Arabidopsis thaliana	89-94
15923334-5	2005	The genes encoding the flavonoid biosynthesis enzymes chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, and flavonol synthase were identified as target genes.	Flavonoids	23-32	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	54-71
15809162-1	2005	Inhibitory activity against aldose reductase enzyme of flavonoid derivatives were modelled using 11 kinds of molecular descriptors from Dragon software.	Flavonoids	55-64	aldo-keto reductase family 1 member B	Homo sapiens	28-44
15814851-5	2005	Nonsteroidal aromatase inhibitors can be divided into three classes: aminoglutethimide-like molecules, imidazole/triazole derivatives, and flavonoid analogs.	Flavonoids	139-148	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	13-22
15863905-3	2005	These flavonoids significantly and dose-dependently inhibited the production of the inflammatory mediator nitric oxide (NO), and the cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages, without displaying cytotoxicity.	Flavonoids	6-16	tumor necrosis factor	Mus musculus	144-177
15863905-3	2005	These flavonoids significantly and dose-dependently inhibited the production of the inflammatory mediator nitric oxide (NO), and the cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages, without displaying cytotoxicity.	Flavonoids	6-16	toll-like receptor 4	Mus musculus	227-230
15863905-3	2005	These flavonoids significantly and dose-dependently inhibited the production of the inflammatory mediator nitric oxide (NO), and the cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages, without displaying cytotoxicity.	Flavonoids	6-16	interferon gamma	Mus musculus	236-258
16158939-0	2005	Targeting of focal adhesion kinase by flavonoids and small-interfering RNAs reduces tumor cell migration ability.	Flavonoids	38-48	protein tyrosine kinase 2	Homo sapiens	13-34
16158939-3	2005	In the first, the biological functions of FAK were examined using flavonoid inhibition.	Flavonoids	66-75	protein tyrosine kinase 2	Homo sapiens	42-45
16158945-8	2005	An undetectable expression of Bcl-2 protein in control and drug-treated HSC-2 cells may explain the relatively higher sensitivity of this cell line to stilbenes and flavonoids.	Flavonoids	165-175	BCL2 apoptosis regulator	Homo sapiens	30-35
15975156-8	2005	In addition, immunochemical staining and Western blot analysis revealed that anti-apoptotic Bcl-2 expression was enhanced following treatment with these protective flavonoids.	Flavonoids	164-174	BCL2 apoptosis regulator	Homo sapiens	92-97
15975156-9	2005	However, Bax expression and caspase-3 cleavage stimulated by 18 h incubation with oxidized LDL were reduced following treatment with these protective flavonoids.	Flavonoids	150-160	BCL2 associated X, apoptosis regulator	Homo sapiens	9-12
15975156-9	2005	However, Bax expression and caspase-3 cleavage stimulated by 18 h incubation with oxidized LDL were reduced following treatment with these protective flavonoids.	Flavonoids	150-160	caspase 3	Homo sapiens	28-37
15975156-10	2005	The down-regulation of Bcl-2 and up-regulation of caspase-3 activation were reversed by the cytoprotective flavonoids, (-)-epigallocatechin gallate, quercetin and hesperetin, at &gt;/=10 microm.	Flavonoids	107-117	BCL2 apoptosis regulator	Homo sapiens	23-28
15975156-10	2005	The down-regulation of Bcl-2 and up-regulation of caspase-3 activation were reversed by the cytoprotective flavonoids, (-)-epigallocatechin gallate, quercetin and hesperetin, at &gt;/=10 microm.	Flavonoids	107-117	caspase 3	Homo sapiens	50-59
15820069-0	2005	[Changes in apoptosis-related genes expression profile in human breast carcinoma cell line Bcap-37 induced by flavonoids from seed residues of Hippophae Rhamnoides L].	Flavonoids	110-120	prohibitin 2	Homo sapiens	91-98
15659385-6	2005	We identified chlorogenic acid as a specific IPMK inhibitor whereas the flavonoids myricetin, 3",4",7,8-tetrahydroxyflavone and EGCG inhibit preferentially IP3K-A and IP3K-C.	Flavonoids	72-82	inositol-trisphosphate 3-kinase A	Homo sapiens	156-162
15659385-6	2005	We identified chlorogenic acid as a specific IPMK inhibitor whereas the flavonoids myricetin, 3",4",7,8-tetrahydroxyflavone and EGCG inhibit preferentially IP3K-A and IP3K-C.	Flavonoids	72-82	inositol-trisphosphate 3-kinase C	Homo sapiens	167-173
15820069-2	2005	This study was designed to investigate changes in apoptosis-related genes expression profile in human breast carcinoma cell line Bcap-37 induced by flavonoids from seed residues of Hippophae rhamnoides L. (FHR) with cDNA microarray, and to explore possible mechanism of signal transduction on apoptosis.	Flavonoids	148-158	prohibitin 2	Homo sapiens	129-136
15778463-9	2005	We also reconstructed the flavonoid pathway by coexpressing CHI with either flavanone 3beta-hydroxylase or flavone synthase II.	Flavonoids	26-35	flavone synthase II	Glycine max	107-126
15795422-6	2005	Micromolar (-)epigallocatechin gallate and quercetin partially eliminated the dichlorodihydrofluorescein (DCF) and phospho-p53 staining, suggesting that these flavonoids inhibited the accumulation of intracellular oxidants and nuclear transactivation of p53 in H2O2-exposed cells.	Flavonoids	159-169	tumor protein p53	Homo sapiens	123-126
15795422-6	2005	Micromolar (-)epigallocatechin gallate and quercetin partially eliminated the dichlorodihydrofluorescein (DCF) and phospho-p53 staining, suggesting that these flavonoids inhibited the accumulation of intracellular oxidants and nuclear transactivation of p53 in H2O2-exposed cells.	Flavonoids	159-169	tumor protein p53	Homo sapiens	254-257
16147863-1	2005	Flavanone 3-hydroxylase (F3H) is a key enzyme in the flavonoid biosynthetic pathway, providing a branching point for the biosynthesis of different flavonoids, including the formation of 3-deoxy and 3-hydroxy flavonoids found in the silks of maize.	Flavonoids	53-62	Flavanone 3-dioxygenase 1	Zea mays	0-23
16147863-1	2005	Flavanone 3-hydroxylase (F3H) is a key enzyme in the flavonoid biosynthetic pathway, providing a branching point for the biosynthesis of different flavonoids, including the formation of 3-deoxy and 3-hydroxy flavonoids found in the silks of maize.	Flavonoids	53-62	Flavanone 3-dioxygenase 1	Zea mays	25-28
16147863-1	2005	Flavanone 3-hydroxylase (F3H) is a key enzyme in the flavonoid biosynthetic pathway, providing a branching point for the biosynthesis of different flavonoids, including the formation of 3-deoxy and 3-hydroxy flavonoids found in the silks of maize.	Flavonoids	147-157	Flavanone 3-dioxygenase 1	Zea mays	0-23
16147863-1	2005	Flavanone 3-hydroxylase (F3H) is a key enzyme in the flavonoid biosynthetic pathway, providing a branching point for the biosynthesis of different flavonoids, including the formation of 3-deoxy and 3-hydroxy flavonoids found in the silks of maize.	Flavonoids	147-157	Flavanone 3-dioxygenase 1	Zea mays	25-28
15795422-10	2005	Additionally, the upregulation of caspase-3 activation was reversed by these flavonoids at &gt; or =10 micromol/L; these inhibitory effects were dose dependent.	Flavonoids	77-87	caspase 3	Homo sapiens	34-43
15807784-2	2005	Here, we report a comprehensive analysis of the metabolome and transcriptome of Arabidopsis thaliana over-expressing the PAP1 gene encoding an MYB transcription factor, for the identification of novel gene functions involved in flavonoid biosynthesis.	Flavonoids	228-237	phosphatidic acid phosphatase 1	Arabidopsis thaliana	121-125
15713544-3	2005	Chemopreventive agents containing high levels of flavonoids and steroids-like compounds are known to suppress CYP1A1.	Flavonoids	49-59	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	110-116
15713544-4	2005	This study was carried out for assessment of the genomic and proteomic effects of caraway (Carum carvi) extracts containing high levels of both flavonoids and steroid-like substances on ethoxy resorufin dealkylation (EROD) activity and CYP1A1 at mRNA levels.	Flavonoids	144-154	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	236-242
15469417-2	2005	Glucose uptake by some members of the GLUT family, mainly GLUT1, is inhibited by flavonoids, the natural polyphenols present in fruits, vegetables and wine.	Flavonoids	81-91	glutaminase	Rattus norvegicus	38-42
15469417-2	2005	Glucose uptake by some members of the GLUT family, mainly GLUT1, is inhibited by flavonoids, the natural polyphenols present in fruits, vegetables and wine.	Flavonoids	81-91	solute carrier family 2 member 1	Rattus norvegicus	58-63
15469417-7	2005	To obtain a better understanding of the interaction among GLUT4 and flavonoids, we have derived a GLUT4 three-dimensional molecular comparative model, using structural co-ordinates from a GLUT3 comparative model and a mechanosensitive ion channel [PDB (Protein Data Bank) code 1MSL] solved by X-ray diffraction.	Flavonoids	68-78	solute carrier family 2 member 4	Rattus norvegicus	98-103
15469417-9	2005	Furthermore, the results suggest that GLUT transporters are involved in flavonoid incorporation into cells.	Flavonoids	72-81	glutaminase	Rattus norvegicus	38-42
15740021-6	2005	The present results showed that the major flavonoids of cocoa, epicatechin and catechin, protect PC12 cells from Abeta-induced neurotoxicity, and suggest that cocoa may have anti-neurodegenerative effect in addition to other known chemopreventive effects.	Flavonoids	42-52	amyloid beta precursor protein	Rattus norvegicus	113-118
15698795-0	2005	Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential.	Flavonoids	26-36	coagulation factor X	Homo sapiens	92-101
15698795-4	2005	Most per-sulfated flavonoids studied are activators of antithrombin for accelerated inhibition of factor Xa, a key enzyme of the blood coagulation cascade.	Flavonoids	18-28	serpin family C member 1	Homo sapiens	55-67
15698784-1	2005	Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as alpha-glucosidase inhibitors.	Flavonoids	71-80	sucrase-isomaltase	Homo sapiens	112-129
15698795-4	2005	Most per-sulfated flavonoids studied are activators of antithrombin for accelerated inhibition of factor Xa, a key enzyme of the blood coagulation cascade.	Flavonoids	18-28	coagulation factor X	Homo sapiens	98-107
15698795-5	2005	As a group the per-sulfated flavonoids possess a range of factor Xa inhibition potential.	Flavonoids	28-38	coagulation factor X	Homo sapiens	58-67
15608138-2	2005	Flavonoids, a major class of natural compounds widely present in foods and herbal products, have been shown to be human BCRP inhibitors.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	120-124
15757658-2	2005	Attempting to unravel the flavonoid"s action mechanism, we found that it inhibited extracellular-signal-regulated kinases 1/2 (ERK1/2) phosphorylation in a dose- and time-dependent way.	Flavonoids	26-35	mitogen-activated protein kinase 1	Homo sapiens	83-125
15757658-2	2005	Attempting to unravel the flavonoid"s action mechanism, we found that it inhibited extracellular-signal-regulated kinases 1/2 (ERK1/2) phosphorylation in a dose- and time-dependent way.	Flavonoids	26-35	mitogen-activated protein kinase 3	Homo sapiens	127-133
15608138-7	2005	The reason(s) for this lack of in vitro-in vivo association may be the lack of potent inhibition activity of the flavonoids against mouse or rat BCRP, as evidenced by our observation that these flavonoids have only weak, if any, inhibition activity against mouse Bcrp1-mediated transport of topotecan in MDCK-Bcrp1 cells.	Flavonoids	113-123	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	145-149
15788228-2	2005	The synergistic effects of flavonoids and ascorbate on DNA degradation induced by the BLM-Fe complex were observed to be greater with flavonoids such as isorhamnetin, kaempferol and morin, which accelerated oxidation more markedly in the presence, than in the absence of BLM.	Flavonoids	27-37	BLM RecQ like helicase	Homo sapiens	86-89
15788228-2	2005	The synergistic effects of flavonoids and ascorbate on DNA degradation induced by the BLM-Fe complex were observed to be greater with flavonoids such as isorhamnetin, kaempferol and morin, which accelerated oxidation more markedly in the presence, than in the absence of BLM.	Flavonoids	27-37	BLM RecQ like helicase	Homo sapiens	271-274
15788228-2	2005	The synergistic effects of flavonoids and ascorbate on DNA degradation induced by the BLM-Fe complex were observed to be greater with flavonoids such as isorhamnetin, kaempferol and morin, which accelerated oxidation more markedly in the presence, than in the absence of BLM.	Flavonoids	134-144	BLM RecQ like helicase	Homo sapiens	86-89
15788228-2	2005	The synergistic effects of flavonoids and ascorbate on DNA degradation induced by the BLM-Fe complex were observed to be greater with flavonoids such as isorhamnetin, kaempferol and morin, which accelerated oxidation more markedly in the presence, than in the absence of BLM.	Flavonoids	134-144	BLM RecQ like helicase	Homo sapiens	271-274
15788228-4	2005	Consequently, there was a good correlation between oxidation of flavonoids accelerated by BLM and the extent of DNA degradation promoted synergistically with ascorbate.	Flavonoids	64-74	BLM RecQ like helicase	Homo sapiens	90-93
15788228-5	2005	Our previous studies indicated that oxidation of flavonoids accelerated by BLM and DNA degradation promoted by flavonoids were not correlated with Fe(III)-reducing activity of flavonoids.	Flavonoids	49-59	BLM RecQ like helicase	Homo sapiens	75-78
15788228-9	2005	Therefore, it is suggested that the synergistic DNA degradation caused by flavonoids and ascorbate in the BLM-Fe redox cycle arose from the difference in the reductive processes in which flavonoids and ascorbate mainly act.	Flavonoids	74-84	BLM RecQ like helicase	Homo sapiens	106-109
15788228-9	2005	Therefore, it is suggested that the synergistic DNA degradation caused by flavonoids and ascorbate in the BLM-Fe redox cycle arose from the difference in the reductive processes in which flavonoids and ascorbate mainly act.	Flavonoids	187-197	BLM RecQ like helicase	Homo sapiens	106-109
15316927-7	2005	Results of the present study provide scientific evidence to suggest that rutinose at C7 is a negative moiety in flavonoid inhibition of LPS-induced NO production, and that HO-1 is involved in the inhibitory mechanism of flavonoids on LPS-induced iNOS and NO production.	Flavonoids	220-230	heme oxygenase 1	Mus musculus	172-176
16059668-0	2005	An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network.	Flavonoids	36-46	phosphoglycolate phosphatase	Mus musculus	50-64
16059668-2	2005	In order to aid in the development of potential P-gp inhibitors, we constructed a quantitative structure-activity relationship (QSAR) model of flavonoids as P-gp inhibitors based on Bayesian-regularized neural network (BRNN).	Flavonoids	143-153	phosphoglycolate phosphatase	Mus musculus	48-52
16059668-2	2005	In order to aid in the development of potential P-gp inhibitors, we constructed a quantitative structure-activity relationship (QSAR) model of flavonoids as P-gp inhibitors based on Bayesian-regularized neural network (BRNN).	Flavonoids	143-153	phosphoglycolate phosphatase	Mus musculus	157-161
16059668-3	2005	A dataset of 57 flavonoids collected from a literature binding to the C-terminal nucleotide-binding domain of mouse P-gp was compiled.	Flavonoids	16-26	phosphoglycolate phosphatase	Mus musculus	116-120
16059668-8	2005	Our study indicates that the BRNN-based in silico model has good potential in facilitating the prediction of P-gp flavonoid inhibitors and might be applied in further drug design.	Flavonoids	114-123	phosphoglycolate phosphatase	Mus musculus	109-113
15800396-9	2005	We conclude that plant-originated flavonoid substances are highly gastroprotective probably due to enhancement of the expression of constitutive NOS and release of NO and neuropeptides such as calcitonin gene related peptide (CGRP) released from sensory afferent nerves increasing gastric microcirculation.	Flavonoids	34-43	calcitonin-related polypeptide alpha	Rattus norvegicus	193-224
15800396-9	2005	We conclude that plant-originated flavonoid substances are highly gastroprotective probably due to enhancement of the expression of constitutive NOS and release of NO and neuropeptides such as calcitonin gene related peptide (CGRP) released from sensory afferent nerves increasing gastric microcirculation.	Flavonoids	34-43	calcitonin-related polypeptide alpha	Rattus norvegicus	226-230
15652241-2	2005	To study the pathogenesis of DM1, we constructed a DM1 cell culture model using a PC12 neuronal cell line and screened flavonoids that ameliorate this mRNA gain of function.	Flavonoids	119-129	DM1 protein kinase	Homo sapiens	29-32
15652241-2	2005	To study the pathogenesis of DM1, we constructed a DM1 cell culture model using a PC12 neuronal cell line and screened flavonoids that ameliorate this mRNA gain of function.	Flavonoids	119-129	DM1 protein kinase	Homo sapiens	51-54
15703835-5	2005	Some naturally occurring flavonoid compounds such as apigenin can function to block cell signaling cascades such as MAPK.	Flavonoids	25-34	mitogen-activated protein kinase 1	Homo sapiens	116-120
15670588-0	2005	Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.	Flavonoids	60-69	ATP binding cassette subfamily C member 1	Canis lupus familiaris	93-130
15670588-1	2005	In the present study, the effects of a large series of flavonoids on multidrug resistance proteins (MRPs) were studied in MRP1 and MRP2 transfected MDCKII cells.	Flavonoids	55-65	ATP binding cassette subfamily C member 2	Canis lupus familiaris	131-135
15670588-2	2005	The results were used to define the structural requirements of flavonoids necessary for potent inhibition of MRP1- and MRP2-mediated calcein transport in a cellular model.	Flavonoids	63-73	ATP binding cassette subfamily C member 1	Canis lupus familiaris	109-113
15670588-2	2005	The results were used to define the structural requirements of flavonoids necessary for potent inhibition of MRP1- and MRP2-mediated calcein transport in a cellular model.	Flavonoids	63-73	ATP binding cassette subfamily C member 2	Canis lupus familiaris	119-123
15670588-3	2005	Several of the methoxylated flavonoids are among the best MRP1 inhibitors (IC(50) values, ranging between 2.7 and 14.3 microM) followed by robinetin, myricetin and quercetin (IC(50) values ranging between 13.6 and 21.8 microM).	Flavonoids	28-38	ATP binding cassette subfamily C member 1	Canis lupus familiaris	58-62
15670588-7	2005	For inhibition of MRP1, a quantitative structure activity relationship (QSAR) was obtained that indicates three structural characteristics to be of major importance for MRP1 inhibition by flavonoids: the total number of methoxylated moieties, the total number of hydroxyl groups and the dihedral angle between the B- and C-ring.	Flavonoids	188-198	ATP binding cassette subfamily C member 1	Canis lupus familiaris	18-22
15670588-7	2005	For inhibition of MRP1, a quantitative structure activity relationship (QSAR) was obtained that indicates three structural characteristics to be of major importance for MRP1 inhibition by flavonoids: the total number of methoxylated moieties, the total number of hydroxyl groups and the dihedral angle between the B- and C-ring.	Flavonoids	188-198	ATP binding cassette subfamily C member 1	Canis lupus familiaris	169-173
15670588-10	2005	Ultimately, MRP2 displays higher selectivity for flavonoid type inhibition than MRP1.	Flavonoids	49-58	ATP binding cassette subfamily C member 2	Canis lupus familiaris	12-16
15695592-5	2005	A quantitative analysis of extractable flavonoids in aha10 seeds revealed an approximately 100-fold reduction of proanthocyanidin (PA), one of the two major end-product pigments in the flavonoid biosynthetic pathway.	Flavonoids	39-49	autoinhibited H[+]-ATPase 	Arabidopsis thaliana	53-58
15695592-5	2005	A quantitative analysis of extractable flavonoids in aha10 seeds revealed an approximately 100-fold reduction of proanthocyanidin (PA), one of the two major end-product pigments in the flavonoid biosynthetic pathway.	Flavonoids	39-48	autoinhibited H[+]-ATPase 	Arabidopsis thaliana	53-58
15695592-9	2005	The endothelial cells in aha10 mutants are otherwise healthy, as indicated by the lack of a significant decrease in (i) the accumulation of other flavonoid pathway end products, such as anthocyanins, and (ii) mRNA levels for two endothelium-specific transcripts (TT12 and BAN).	Flavonoids	146-155	autoinhibited H[+]-ATPase 	Arabidopsis thaliana	25-30
15684479-5	2005	Using 2",7"-dichlorofluorescin diacetate (DCF-DA), the intracellular reactive oxygen species (ROS) level of flavonoid-treated TIG-1 cells was examined.	Flavonoids	108-117	retinoic acid receptor responder 1	Homo sapiens	126-131
15316927-7	2005	Results of the present study provide scientific evidence to suggest that rutinose at C7 is a negative moiety in flavonoid inhibition of LPS-induced NO production, and that HO-1 is involved in the inhibitory mechanism of flavonoids on LPS-induced iNOS and NO production.	Flavonoids	220-230	nitric oxide synthase 2, inducible	Mus musculus	246-250
15694690-9	2005	Support for this hypothesis comes from the recent observation that the iron chelating flavonoid quercetin both directly activates ATM and protects neuronal cells from the toxic effects of the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	Flavonoids	86-95	ataxia telangiectasia mutated	Mus musculus	130-133
15828450-2	2005	This study demonstrates that some putative flavonoids, i.e., flavonols (quercetin and kaempferol) and isoflavones (genistein and daidzein) markedly increase the sensitivity of the multidrug-resistant human cervical carcinoma KB-V1 cells (high Pgp expression) to vinblastine and paclitaxel dose-dependently, and also decrease the relative resistance of these anti-cancer-drugs in KB-V1 cells.	Flavonoids	43-53	ATP binding cassette subfamily B member 1	Homo sapiens	243-246
15729616-0	2005	Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin.	Flavonoids	112-121	phosphodiesterase 3A	Rattus norvegicus	15-50
16019943-0	2005	Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships.	Flavonoids	19-32	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	42-49
16019943-4	2005	This study proposes features of the bioflavonoid structure necessary to confer it as a substrate of UGT1A10.	Flavonoids	36-48	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	100-107
15585197-3	2005	Our current studies examined whether citrus flavonoids possess an additional antiatherogenic effect by modulating macrophage metabolism of the specific class A scavenger receptor (SR-A) ligand, acetylated LDL (acLDL).	Flavonoids	44-54	macrophage scavenger receptor 1	Mus musculus	180-184
15585197-4	2005	In this study, both acLDL-metabolism and SR-A expression by cultured murine J774A.1 macrophages was examined following 24 h pretreatment (100 microM) with the flavonoids: naringenin (from grapefruit), hesperetin (from oranges), and tangeretin and nobiletin (from tangerines).	Flavonoids	159-169	macrophage scavenger receptor 1	Mus musculus	41-45
15480888-11	2005	The data indicate co-ordinate regulation of flavonoid biosynthetic genes which code for the enzymes 4-coumarate-CoA ligase, chalcone synthase, chalcone isomerase, flavonone hydroxylase, anthocyanidin reductase and cytochrome b5.	Flavonoids	44-53	type III polyketide synthase B	Vitis vinifera	124-209
15480888-11	2005	The data indicate co-ordinate regulation of flavonoid biosynthetic genes which code for the enzymes 4-coumarate-CoA ligase, chalcone synthase, chalcone isomerase, flavonone hydroxylase, anthocyanidin reductase and cytochrome b5.	Flavonoids	44-53	cytochrome b5	Vitis vinifera	214-227
15922113-4	2005	Interestingly, flavonoids with chemopreventative effects, such as quercetin, genistein, and epigallocatechin gallate activate ATM.	Flavonoids	15-25	ataxia telangiectasia mutated	Mus musculus	126-129
15922113-5	2005	Since ATM activates pathways which increase genomic stability, oxidant resistance, and/or telomere stability, and since many diseases of old age (i.e., cancer, cardiovascular and neurodegenerative disease), result from attenuation of these pathways, pharmacologic manipulation of ATM activity via flavonoid intake may prove useful in slowing the appearance of age-associated disease.	Flavonoids	297-306	ataxia telangiectasia mutated	Mus musculus	6-9
15670046-0	2005	Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor.	Flavonoids	0-10	thromboxane A2 receptor	Homo sapiens	60-83
15581599-1	2005	Multidrug resistance transporter MRP1 could be effectively inhibited by some flavonoids.	Flavonoids	77-87	ATP binding cassette subfamily C member 1	Homo sapiens	33-37
15631523-0	2005	Interaction of flavonoids with bovine serum albumin: a fluorescence quenching study.	Flavonoids	15-25	albumin	Homo sapiens	38-51
15631523-1	2005	The interaction between four flavonoids (catechin, epicatechin, rutin, and quercetin) and bovine serum albumin (BSA) was investigated using tryptophan fluorescence quenching.	Flavonoids	29-39	albumin	Homo sapiens	97-116
15631523-2	2005	Quenching constants were determined using the Stern-Volmer equation to provide a measure of the binding affinity between the flavonoids and BSA.	Flavonoids	125-135	albumin	Homo sapiens	140-143
15631523-7	2005	Furthermore, the data suggested that the association between flavonoids and BSA did not change molecular conformation of BSA and that hydrogen bonding, ionic, and hydrophobic interaction are equally important driving forces for protein-flavonoid association.	Flavonoids	61-71	albumin	Homo sapiens	76-79
15631523-7	2005	Furthermore, the data suggested that the association between flavonoids and BSA did not change molecular conformation of BSA and that hydrogen bonding, ionic, and hydrophobic interaction are equally important driving forces for protein-flavonoid association.	Flavonoids	61-70	albumin	Homo sapiens	76-79
15386368-2	2004	Investigation on the molecular mechanisms triggered by the main green tea flavonoid, (-)epigallocatechin-3-gallate (EGCG), shows that EGCG restrains TRAMP-C1 cell proliferation in a dose-dependent manner, at concentrations (IC(50) &lt; 0.2 microM) equivalent to those measured in the plasma of moderate green-tea drinkers.	Flavonoids	74-83	tumor necrosis factor receptor superfamily, member 25	Mus musculus	149-154
16059641-2	2005	In presented study treatments of human leukemia cells HL60 and their MDR-1 resistant subline HL60/VCR by flavonoids apigenin (API), luteolin (LUT), quercetin (QU) and anticancer drug doxorubicin (DOX) are reported.	Flavonoids	105-115	ATP binding cassette subfamily B member 1	Homo sapiens	69-74
15618424-5	2005	Tomato CRY2 overexpressors show phenotypes similar to but distinct from their Arabidopsis counterparts (hypocotyl and internode shortening under both low- and high-fluence blue light), but also several novel ones, including a high-pigment phenotype, resulting in overproduction of anthocyanins and chlorophyll in leaves and of flavonoids and lycopene in fruits.	Flavonoids	327-337	cryptochrome 2	Arabidopsis thaliana	7-11
15342961-3	2004	The flavonoid naringin prevented the effects of AICAR, okadaic acid, and microcystin on AMPK activation as well as on S6K tail phosphorylation, suggesting AMPK as a mediator of the latter.	Flavonoids	4-13	ribosomal protein S6 kinase B1	Homo sapiens	118-121
15451888-1	2004	Great attention has been recently given to a flavonoid of the anthocyanin class, cyanidin-3-O-beta-glucopyranoside (C-3-G), which is widely spread throughout the plant kingdom, and is present in both fruits and vegetables of human diets.	Flavonoids	45-54	Rap guanine nucleotide exchange factor 1	Homo sapiens	116-121
15595416-0	2004	Prenylated flavonoids as tyrosinase inhibitors.	Flavonoids	11-21	tyrosinase	Homo sapiens	25-35
15516721-8	2004	These results indicate that licorice hydrophobic flavonoids have abdominal fat-lowering and hypoglycemic effects, possibly mediated via activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma).	Flavonoids	49-59	peroxisome proliferator activated receptor gamma	Mus musculus	150-198
15516721-8	2004	These results indicate that licorice hydrophobic flavonoids have abdominal fat-lowering and hypoglycemic effects, possibly mediated via activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma).	Flavonoids	49-59	peroxisome proliferator activated receptor gamma	Mus musculus	200-210
17147621-3	2004	We show here that a chimeric PAP1 repressor, in which the EAR-motif repression domain from SUPERMAN was fused to PAP1, suppressed the expression of four flavonoid biosynthetic genes, namely CHS, DFR, LDOX, and BAN, in siliques, and inhibited the accumulation of proanthocyanidin, even in the presence of an endogenous positive regulator, such as TT2.	Flavonoids	153-162	phosphatidic acid phosphatase 1	Arabidopsis thaliana	29-33
15539763-4	2004	Recent studies have also shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase, and several pivotal cytokines.	Flavonoids	44-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	203-219
17147621-3	2004	We show here that a chimeric PAP1 repressor, in which the EAR-motif repression domain from SUPERMAN was fused to PAP1, suppressed the expression of four flavonoid biosynthetic genes, namely CHS, DFR, LDOX, and BAN, in siliques, and inhibited the accumulation of proanthocyanidin, even in the presence of an endogenous positive regulator, such as TT2.	Flavonoids	153-162	phosphatidic acid phosphatase 1	Arabidopsis thaliana	113-117
17147621-3	2004	We show here that a chimeric PAP1 repressor, in which the EAR-motif repression domain from SUPERMAN was fused to PAP1, suppressed the expression of four flavonoid biosynthetic genes, namely CHS, DFR, LDOX, and BAN, in siliques, and inhibited the accumulation of proanthocyanidin, even in the presence of an endogenous positive regulator, such as TT2.	Flavonoids	153-162	dihydroflavonol 4-reductase	Arabidopsis thaliana	195-198
17147621-3	2004	We show here that a chimeric PAP1 repressor, in which the EAR-motif repression domain from SUPERMAN was fused to PAP1, suppressed the expression of four flavonoid biosynthetic genes, namely CHS, DFR, LDOX, and BAN, in siliques, and inhibited the accumulation of proanthocyanidin, even in the presence of an endogenous positive regulator, such as TT2.	Flavonoids	153-162	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	346-349
21158108-0	2004	[Effect of total flavonoids of Epimedium on gene expression of calmodulin in hypothalamus-pituitary-adreno cortex axis of shenyangxu rats].	Flavonoids	17-27	calmodulin 1	Rattus norvegicus	63-73
15319488-0	2004	Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells.	Flavonoids	80-89	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	39-44
15761540-4	2004	Mutations in the gene encoding 11beta-HSD2 account for the inherited form, but a similar clinical picture to AME occurs following the ingestion of bioflavonoids, licorice and carbenoxolone, which are competitive inhibitors of 11beta-HSD2.	Flavonoids	147-160	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	31-42
15334063-2	2004	In this study, we found that pretreatment with luteolin, a plant flavonoid, greatly sensitized TNFalpha-induced apoptotic cell death in a number of human cancer cell lines; including colorectal cancer COLO205, HCT116 cells and cervical cancer HeLa cells.	Flavonoids	65-74	tumor necrosis factor	Homo sapiens	95-103
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	Flavonoids	119-128	diacylglycerol O-acyltransferase 1	Homo sapiens	23-53
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	Flavonoids	119-128	diacylglycerol O-acyltransferase 1	Homo sapiens	55-59
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	Flavonoids	119-128	microsomal triglyceride transfer protein	Homo sapiens	65-105
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	Flavonoids	119-128	microsomal triglyceride transfer protein	Homo sapiens	107-110
15502363-0	2004	Spectrophotometric and kinetic studies on the binding of the bioflavonoid quercetin to bovine serum albumin.	Flavonoids	61-73	albumin	Homo sapiens	94-107
15502363-1	2004	This work investigates the binding of the bioflavonoid, quercetin, to bovine serum albumin (BSA) by spectrophotometric techniques involving both the conventional and stopped-flow methods.	Flavonoids	42-54	albumin	Homo sapiens	77-90
15761540-4	2004	Mutations in the gene encoding 11beta-HSD2 account for the inherited form, but a similar clinical picture to AME occurs following the ingestion of bioflavonoids, licorice and carbenoxolone, which are competitive inhibitors of 11beta-HSD2.	Flavonoids	147-160	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	226-237
15196053-9	2004	The ability of VBAR to specifically inactivate GST I was exploited further to demonstrate the specific binding of several plant hormones and flavonoids to GST I.	Flavonoids	141-151	glutathione S-transferase 1	Zea mays	47-52
15452083-10	2004	CONCLUSIONS: Sour cherry seed flavonoid-rich extract showed a protective effect against reperfusion-induced injury through its ability to reduce the changes in concentrations of retinal ions through HO-1-related endogenous CO production in the ischemic/reperfused retina.	Flavonoids	30-39	heme oxygenase 1	Rattus norvegicus	199-203
15196053-9	2004	The ability of VBAR to specifically inactivate GST I was exploited further to demonstrate the specific binding of several plant hormones and flavonoids to GST I.	Flavonoids	141-151	glutathione S-transferase 1	Zea mays	155-160
15123766-9	2004	Interestingly, the flavonoids luteolin and cynaroside increased eNOS promoter activity and eNOS mRNA expression, whereas the caffeoylquinic acids cynarin and chlorogenic acid were without effect.	Flavonoids	19-29	nitric oxide synthase 3	Homo sapiens	64-68
15350128-4	2004	The unique active-site pocket in QR2 could potentially bind other natural polyphenols such as flavonoids, as proven by the high affinity exhibited by quercetin toward QR2.	Flavonoids	94-104	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	33-36
15350128-4	2004	The unique active-site pocket in QR2 could potentially bind other natural polyphenols such as flavonoids, as proven by the high affinity exhibited by quercetin toward QR2.	Flavonoids	94-104	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	167-170
15302569-6	2004	MEK inhibitors (PD098059 or U0126) blocked ERK1/2 phosphorylation induced by apigenin and conferred partial protection against this flavonoid.	Flavonoids	132-141	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
15191910-3	2004	Specific members of the flavonoid class of compounds have been shown to increase Cl- conductance of wild-type and DeltaF508 cystic fibrosis transmembrane regulator (CFTR).	Flavonoids	24-33	CF transmembrane conductance regulator	Homo sapiens	165-169
15473664-1	2004	Recent investigations have shown that certain flavonoids, especially flavone derivatives, inhibit nitric oxide (NO) production by inducible NO synthase (iNOS) in macrophages, which contribute their anti-inflammatory action.	Flavonoids	46-56	nitric oxide synthase 2, inducible	Mus musculus	130-151
15473664-1	2004	Recent investigations have shown that certain flavonoids, especially flavone derivatives, inhibit nitric oxide (NO) production by inducible NO synthase (iNOS) in macrophages, which contribute their anti-inflammatory action.	Flavonoids	46-56	nitric oxide synthase 2, inducible	Mus musculus	153-157
15090468-1	2004	The isothiocyanate, sulforaphane and the flavonoid, apigenin modulate gene expression including phase II detoxifying enzymes, such as glutathione S-transferases (GST) and UDP-glucuronosyltransferases (UGT).	Flavonoids	41-50	beta-1,3-glucuronyltransferase 2	Homo sapiens	171-199
15090468-1	2004	The isothiocyanate, sulforaphane and the flavonoid, apigenin modulate gene expression including phase II detoxifying enzymes, such as glutathione S-transferases (GST) and UDP-glucuronosyltransferases (UGT).	Flavonoids	41-50	beta-1,3-glucuronyltransferase 2	Homo sapiens	201-204
15487807-8	2004	Quercetin, a flavonoid present in edible fruit, vegetable and wine, was a potent inhibitor of human liver SULT1A1 and estrogen sulfotransferase (EST) activities and the sulfation of resveratrol.	Flavonoids	13-22	sulfotransferase family 1A member 1	Homo sapiens	106-113
15487807-8	2004	Quercetin, a flavonoid present in edible fruit, vegetable and wine, was a potent inhibitor of human liver SULT1A1 and estrogen sulfotransferase (EST) activities and the sulfation of resveratrol.	Flavonoids	13-22	sulfotransferase family 1E member 1	Homo sapiens	118-143
15123766-9	2004	Interestingly, the flavonoids luteolin and cynaroside increased eNOS promoter activity and eNOS mRNA expression, whereas the caffeoylquinic acids cynarin and chlorogenic acid were without effect.	Flavonoids	19-29	nitric oxide synthase 3	Homo sapiens	91-95
15123766-11	2004	Artichoke flavonoids are likely to represent the active ingredients mediating eNOS up-regulation.	Flavonoids	10-20	nitric oxide synthase 3	Homo sapiens	78-82
15322261-0	2004	Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.	Flavonoids	0-10	tumor necrosis factor	Homo sapiens	19-46
15322261-14	2004	Finally, our results suggested that AP-1 seems to play a more significant role than NF-kappaB in the flavonoid-induced ICAM-1 inhibition.	Flavonoids	101-110	intercellular adhesion molecule 1	Homo sapiens	119-125
15322261-0	2004	Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.	Flavonoids	0-10	intercellular adhesion molecule 1	Homo sapiens	72-105
15322261-0	2004	Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.	Flavonoids	0-10	intercellular adhesion molecule 1	Homo sapiens	107-113
15322261-0	2004	Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.	Flavonoids	0-10	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-200
15322261-4	2004	Among those flavonoids tested, kaempferol, chrysin, apigenin, and luteolin are active inhibitors of ICAM-1 expression.	Flavonoids	12-22	intercellular adhesion molecule 1	Homo sapiens	100-106
15322261-14	2004	Finally, our results suggested that AP-1 seems to play a more significant role than NF-kappaB in the flavonoid-induced ICAM-1 inhibition.	Flavonoids	101-110	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-40
15183194-1	2004	Micromolar concentrations of the flavonoid kaempferol were found to efficiently block cerebellar granule cell (CGC) death through low K+-induced apoptosis, as demonstrated by prevention of the activation of caspase-3, internucleosomal DNA fragmentation, and chromatin condensation, without a significant rise in intracellular free Ca2+ concentration.	Flavonoids	33-42	caspase 3	Homo sapiens	207-216
15352502-1	2004	According to the strong application background of bioflavonoid and metal-flavonoid complexes, novel electrospray ionization tandem mass spectrometry (ESI-MSn) was applied to investigate the structure and fragmentation mechanism of transition metal-rutin complexes.	Flavonoids	50-62	moesin	Homo sapiens	154-157
15231263-3	2004	Flavonoids from the plant root trigger bacterial gene expression and the production of lipo-chitooligosaccharide signals (called Nod factors) that are recognized by the plant host.	Flavonoids	0-10	atrophin 1	Homo sapiens	129-132
15326546-6	2004	Based on this large pool of potential cancer chemopreventive compounds, structure-activity relationships are discussed in terms of the quinone reductase induction ability of flavonoids and withanolides and the cyclooxygenase-1 and -2 inhibitory activities of flavanones, flavones and stilbenoids.	Flavonoids	174-184	crystallin, zeta	Mus musculus	135-152
15267241-3	2004	In addition, there are several classes of natural products that exert potent activities in aromatase inhibition, with the flavonoids being most prominent.	Flavonoids	122-132	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	91-100
15225597-0	2004	Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.	Flavonoids	10-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	38-54
15225597-0	2004	Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.	Flavonoids	10-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	56-61
15225597-2	2004	There are numerous reports demonstrating that flavonoids inhibit COX-2 activity.	Flavonoids	46-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
15225597-5	2004	Here, we briefly review the literature on regulation of COX-2 transcription by flavonoids, and report some new preliminary data on Vitamin E and quercetin conjugates.	Flavonoids	79-89	prostaglandin-endoperoxide synthase 2	Homo sapiens	56-61
15225597-10	2004	Flavonoid modulation of COX-2 transcription may therefore be an important mechanism in anti-carcinogenesis.	Flavonoids	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	24-29
15208397-7	2004	Flavonoids inhibit auxin transport primarily at the shoot apex and root tip and appear to modulate vesicular cycling of PIN1 at the root tip.	Flavonoids	0-10	Auxin efflux carrier family protein	Arabidopsis thaliana	120-124
15290869-0	2004	Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport.	Flavonoids	29-39	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	43-75
15290869-0	2004	Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport.	Flavonoids	29-39	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	77-82
15290869-1	2004	PURPOSE: The purpose of this study was to determine the dynamic parameter (EC50) of flavonoids apigenin, biochanin A, chrysin, genistein, kaempferol, hesperetin, naringenin, and silymarin for breast cancer resistance protein (BCRP) inhibition when used alone, and to evaluate their potential interactions (additive, synergistic, or antagonistic) with regards to BCRP inhibition when used in multiple-flavonoid combinations.	Flavonoids	84-93	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	192-224
15290869-1	2004	PURPOSE: The purpose of this study was to determine the dynamic parameter (EC50) of flavonoids apigenin, biochanin A, chrysin, genistein, kaempferol, hesperetin, naringenin, and silymarin for breast cancer resistance protein (BCRP) inhibition when used alone, and to evaluate their potential interactions (additive, synergistic, or antagonistic) with regards to BCRP inhibition when used in multiple-flavonoid combinations.	Flavonoids	84-93	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	226-230
15290869-1	2004	PURPOSE: The purpose of this study was to determine the dynamic parameter (EC50) of flavonoids apigenin, biochanin A, chrysin, genistein, kaempferol, hesperetin, naringenin, and silymarin for breast cancer resistance protein (BCRP) inhibition when used alone, and to evaluate their potential interactions (additive, synergistic, or antagonistic) with regards to BCRP inhibition when used in multiple-flavonoid combinations.	Flavonoids	84-93	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	362-366
15290869-2	2004	METHODS: The effects of flavonoids on BCRP-mediated transport were examined by evaluating their effects on mitoxantrone accumulation and cytotoxicity in MCF-7 MX100 cells overexpressing BCRP.	Flavonoids	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	38-42
15290869-2	2004	METHODS: The effects of flavonoids on BCRP-mediated transport were examined by evaluating their effects on mitoxantrone accumulation and cytotoxicity in MCF-7 MX100 cells overexpressing BCRP.	Flavonoids	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	186-190
15096521-0	2004	The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils.	Flavonoids	4-13	synuclein alpha	Homo sapiens	49-64
15290869-4	2004	The potential interactions among multiple flavonoids with regard to BCRP inhibition were assessed by isobologram and Berenbaum"s interaction index methods.	Flavonoids	42-52	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	68-72
15290869-6	2004	Quantitative analysis of the combined effects of multiple flavonoids on mitoxantrone accumulation indicated that these flavonoids act additively in inhibiting BCRP when given as 2-, 3-, 5-, or 8-flavonoid combinations with equimolar concentrations of all constituents.	Flavonoids	119-129	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	159-163
15290869-8	2004	CONCLUSIONS: The additive effects of multiple flavonoids for BCRP inhibition suggests that prediction of BCRP-mediated food (herbal product)-drug interactions should also take into consideration the presence of multiple flavonoids and provides a rationale for using "flavonoid cocktails" as a potential approach for multidrug resistance reversal in cancer treatment.	Flavonoids	46-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-65
15290869-8	2004	CONCLUSIONS: The additive effects of multiple flavonoids for BCRP inhibition suggests that prediction of BCRP-mediated food (herbal product)-drug interactions should also take into consideration the presence of multiple flavonoids and provides a rationale for using "flavonoid cocktails" as a potential approach for multidrug resistance reversal in cancer treatment.	Flavonoids	46-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	105-109
15290869-8	2004	CONCLUSIONS: The additive effects of multiple flavonoids for BCRP inhibition suggests that prediction of BCRP-mediated food (herbal product)-drug interactions should also take into consideration the presence of multiple flavonoids and provides a rationale for using "flavonoid cocktails" as a potential approach for multidrug resistance reversal in cancer treatment.	Flavonoids	220-230	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-65
15290869-8	2004	CONCLUSIONS: The additive effects of multiple flavonoids for BCRP inhibition suggests that prediction of BCRP-mediated food (herbal product)-drug interactions should also take into consideration the presence of multiple flavonoids and provides a rationale for using "flavonoid cocktails" as a potential approach for multidrug resistance reversal in cancer treatment.	Flavonoids	220-230	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	105-109
15290869-8	2004	CONCLUSIONS: The additive effects of multiple flavonoids for BCRP inhibition suggests that prediction of BCRP-mediated food (herbal product)-drug interactions should also take into consideration the presence of multiple flavonoids and provides a rationale for using "flavonoid cocktails" as a potential approach for multidrug resistance reversal in cancer treatment.	Flavonoids	46-55	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-65
15290869-8	2004	CONCLUSIONS: The additive effects of multiple flavonoids for BCRP inhibition suggests that prediction of BCRP-mediated food (herbal product)-drug interactions should also take into consideration the presence of multiple flavonoids and provides a rationale for using "flavonoid cocktails" as a potential approach for multidrug resistance reversal in cancer treatment.	Flavonoids	46-55	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	105-109
15212458-5	2004	These results suggest that baicalein as well as baicalin can reduce the cytotoxicity of Abeta protein in PC12 cells, possibly by a reduction of oxidative stress, and these flavonoids may be useful in the chemoprevention of Alzheimer"s disease.	Flavonoids	172-182	amyloid beta precursor protein	Rattus norvegicus	88-93
15205350-0	2004	Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.	Flavonoids	15-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	34-66
15096096-2	2004	In the present study, F3H (flavanone 3-hydroxylase), a key enzyme in the flavonoid biosynthetic pathway that participates in the formation of red-coloured anthocyanins, was used as a target for RNase P-mediated gene disruption in maize cells.	Flavonoids	73-82	Flavanone 3-dioxygenase 1	Zea mays	22-50
15205350-0	2004	Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.	Flavonoids	15-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	67-72
15205350-5	2004	Some glycosylated flavonoids, such as naringenin-7-glucoside, also effectively inhibited BCRP.	Flavonoids	18-28	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	89-93
15205350-4	2004	In this study, we show that phytoestrogens/flavonoids, such as genistein, naringenin, acacetin, and kaempferol, potentiated the cytotoxicity of SN-38 and mitoxantrone in BCRP-transduced K562 (K562/BCRP) cells.	Flavonoids	43-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	170-174
15205350-14	2004	The results have two important clinical implications: (a) flavonoids and glycosylated flavonoids may be useful in overcoming BCRP-mediated drug resistance in tumor cells; and (b) coadministration of flavonoids with BCRP-substrate antitumor agents may alter the pharmacokinetics and consequently increase the toxicity of specific antitumor agents in cancer patients.	Flavonoids	58-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	125-129
15205350-14	2004	The results have two important clinical implications: (a) flavonoids and glycosylated flavonoids may be useful in overcoming BCRP-mediated drug resistance in tumor cells; and (b) coadministration of flavonoids with BCRP-substrate antitumor agents may alter the pharmacokinetics and consequently increase the toxicity of specific antitumor agents in cancer patients.	Flavonoids	58-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	215-219
15205350-4	2004	In this study, we show that phytoestrogens/flavonoids, such as genistein, naringenin, acacetin, and kaempferol, potentiated the cytotoxicity of SN-38 and mitoxantrone in BCRP-transduced K562 (K562/BCRP) cells.	Flavonoids	43-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	197-201
15205350-14	2004	The results have two important clinical implications: (a) flavonoids and glycosylated flavonoids may be useful in overcoming BCRP-mediated drug resistance in tumor cells; and (b) coadministration of flavonoids with BCRP-substrate antitumor agents may alter the pharmacokinetics and consequently increase the toxicity of specific antitumor agents in cancer patients.	Flavonoids	86-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	125-129
15205350-14	2004	The results have two important clinical implications: (a) flavonoids and glycosylated flavonoids may be useful in overcoming BCRP-mediated drug resistance in tumor cells; and (b) coadministration of flavonoids with BCRP-substrate antitumor agents may alter the pharmacokinetics and consequently increase the toxicity of specific antitumor agents in cancer patients.	Flavonoids	86-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	215-219
15153793-0	2004	Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils.	Flavonoids	0-10	interleukin 13	Homo sapiens	86-100
15205350-14	2004	The results have two important clinical implications: (a) flavonoids and glycosylated flavonoids may be useful in overcoming BCRP-mediated drug resistance in tumor cells; and (b) coadministration of flavonoids with BCRP-substrate antitumor agents may alter the pharmacokinetics and consequently increase the toxicity of specific antitumor agents in cancer patients.	Flavonoids	86-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	125-129
15205350-14	2004	The results have two important clinical implications: (a) flavonoids and glycosylated flavonoids may be useful in overcoming BCRP-mediated drug resistance in tumor cells; and (b) coadministration of flavonoids with BCRP-substrate antitumor agents may alter the pharmacokinetics and consequently increase the toxicity of specific antitumor agents in cancer patients.	Flavonoids	86-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	215-219
15135307-0	2004	Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells.	Flavonoids	127-137	epidermal growth factor receptor	Homo sapiens	25-57
15135307-0	2004	Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells.	Flavonoids	127-137	protein tyrosine kinase 2	Homo sapiens	78-99
15153793-0	2004	Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils.	Flavonoids	0-10	interleukin 4	Homo sapiens	68-81
15153793-2	2004	This time, we investigated the inhibition of IL-4 and IL-13 production by basophils by other flavonoids and attempted to determine the fundamental structure of flavonoids related to inhibition.	Flavonoids	93-103	interleukin 4	Homo sapiens	45-49
15153793-2	2004	This time, we investigated the inhibition of IL-4 and IL-13 production by basophils by other flavonoids and attempted to determine the fundamental structure of flavonoids related to inhibition.	Flavonoids	93-103	interleukin 13	Homo sapiens	54-59
15153793-7	2004	Regarding the inhibitory activity of flavonoids on IL-4 synthesis by T cells, peripheral blood mononuclear cells were cultured with flavonoids in anti-CD3-antibody-bound plates for 2 days.	Flavonoids	37-47	interleukin 4	Homo sapiens	51-55
15153793-9	2004	At higher concentrations, these flavonoids suppressed IL-4 production by T cells.	Flavonoids	32-42	interleukin 4	Homo sapiens	54-58
15153793-11	2004	CONCLUSIONS: Due to the inhibitory activity of flavonoids on IL-4 and IL-13 synthesis, it can be expected that the intake of flavonoids, depending on the quantity and quality, may ameliorate allergic symptoms or prevent the onset of allergic diseases.	Flavonoids	47-57	interleukin 4	Homo sapiens	61-65
15153793-11	2004	CONCLUSIONS: Due to the inhibitory activity of flavonoids on IL-4 and IL-13 synthesis, it can be expected that the intake of flavonoids, depending on the quantity and quality, may ameliorate allergic symptoms or prevent the onset of allergic diseases.	Flavonoids	47-57	interleukin 13	Homo sapiens	70-75
15153793-11	2004	CONCLUSIONS: Due to the inhibitory activity of flavonoids on IL-4 and IL-13 synthesis, it can be expected that the intake of flavonoids, depending on the quantity and quality, may ameliorate allergic symptoms or prevent the onset of allergic diseases.	Flavonoids	125-135	interleukin 4	Homo sapiens	61-65
15153793-11	2004	CONCLUSIONS: Due to the inhibitory activity of flavonoids on IL-4 and IL-13 synthesis, it can be expected that the intake of flavonoids, depending on the quantity and quality, may ameliorate allergic symptoms or prevent the onset of allergic diseases.	Flavonoids	125-135	interleukin 13	Homo sapiens	70-75
15100171-0	2004	Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase.	Flavonoids	54-67	catechol-O-methyltransferase	Homo sapiens	146-174
15108355-0	2004	Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.	Flavonoids	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	70-75
15108355-0	2004	Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.	Flavonoids	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-112
15108355-0	2004	Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.	Flavonoids	0-9	jun proto-oncogene	Mus musculus	117-121
15041478-11	2004	To identify the GS-X pump responsible for the DNP-SG efflux in MCF7 cells, the effects of three characteristic flavonoids quercetin, flavone and taxifolin on MRP1 and MRP2 activity were studied using transfected MDCKII cells.	Flavonoids	111-121	ATP binding cassette subfamily C member 1	Homo sapiens	16-20
15100171-7	2004	We also determined, for comparison, two common bioflavonoids (quercetin and fisetin) for their inhibitory effects on human liver COMT-mediated O-methylation of catechol estrogens.	Flavonoids	47-60	catechol-O-methyltransferase	Homo sapiens	129-133
15100171-9	2004	Enzyme kinetic analyses showed that both tea catechins and bioflavonoids inhibited human liver COMT-mediated O-methylation of 4-OH-E(2) (a representative substrate) with a mixed mechanism of inhibition (competitive plus noncompetitive).	Flavonoids	59-72	catechol-O-methyltransferase	Homo sapiens	95-99
15100171-10	2004	In summary, the catechol-containing tea catechins and bioflavonoids are strong inhibitors of human liver COMT-mediated O-methylation of catechol estrogens.	Flavonoids	54-67	catechol-O-methyltransferase	Homo sapiens	105-109
15102949-0	2004	Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	29-61
15102949-0	2004	Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.	Flavonoids	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	63-68
15102949-3	2004	The interactions of flavonoids with P-glycoprotein and multidrug resistance-associated protein 1 have been reported; however, their interaction with BCRP is unknown.	Flavonoids	20-30	ATP binding cassette subfamily C member 1	Homo sapiens	55-96
15102949-6	2004	Many of the tested flavonoids (50 microM) increased mitoxantrone accumulation in BCRP-overexpressing cells, completely reversing mitoxantrone resistance, with no effect on the corresponding BCRP-negative cells, indicating that these flavonoids are BCRP inhibitors.	Flavonoids	19-29	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	81-85
15041478-0	2004	Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.	Flavonoids	32-41	ATP binding cassette subfamily C member 1	Homo sapiens	100-104
15041478-1	2004	The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5).	Flavonoids	207-217	glutathione S-transferase pi 1	Homo sapiens	135-142
15041478-1	2004	The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5).	Flavonoids	207-217	ATP binding cassette subfamily C member 1	Homo sapiens	148-152
15041478-1	2004	The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5).	Flavonoids	207-217	ATP binding cassette subfamily C member 1	Homo sapiens	159-163
15041478-12	2004	All three flavonoids as well as the typical MRP inhibitor (MK571) affected MRP1-mediated transport activity in a similar way as observed in the MCF7 cells.	Flavonoids	10-20	ATP binding cassette subfamily C member 1	Homo sapiens	75-79
15041478-1	2004	The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5).	Flavonoids	207-217	ATP binding cassette subfamily C member 2	Homo sapiens	168-172
15041478-1	2004	The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5).	Flavonoids	207-217	glutathione S-transferase pi 1	Homo sapiens	222-229
15041478-2	2004	The results reveal that GSTP1-1 activity in MCF7 pMTG5 cells can be inhibited by some flavonoids.	Flavonoids	86-96	glutathione S-transferase pi 1	Homo sapiens	24-31
15041478-4	2004	Other flavonoids like kaempferol, eriodictyol and quercetin showed a moderate GSTP1-1 inhibitory potential.	Flavonoids	6-16	glutathione S-transferase pi 1	Homo sapiens	78-85
15041478-6	2004	Most flavonoids appeared to be potent GS-X transport inhibitors with IC(50) values ranging between 0.8 and 8microM.	Flavonoids	5-15	ATP binding cassette subfamily C member 1	Homo sapiens	38-42
15041478-14	2004	These observations clearly indicate that the GS-X pump activity in the MCF7 cells is likely to be the result of flavonoid-mediated inhibition of MRP1 and not MRP2.	Flavonoids	112-121	ATP binding cassette subfamily C member 1	Homo sapiens	45-49
15041478-14	2004	These observations clearly indicate that the GS-X pump activity in the MCF7 cells is likely to be the result of flavonoid-mediated inhibition of MRP1 and not MRP2.	Flavonoids	112-121	ATP binding cassette subfamily C member 1	Homo sapiens	145-149
15041478-15	2004	Altogether, the present study reveals that a major site for flavonoid interaction with GSH-dependent toxicokinetics is the GS-X pump MRP1 rather than the conjugating GSTP1-1 activity itself.	Flavonoids	60-69	ATP binding cassette subfamily C member 1	Homo sapiens	123-127
15041478-15	2004	Altogether, the present study reveals that a major site for flavonoid interaction with GSH-dependent toxicokinetics is the GS-X pump MRP1 rather than the conjugating GSTP1-1 activity itself.	Flavonoids	60-69	ATP binding cassette subfamily C member 1	Homo sapiens	133-137
15041478-15	2004	Altogether, the present study reveals that a major site for flavonoid interaction with GSH-dependent toxicokinetics is the GS-X pump MRP1 rather than the conjugating GSTP1-1 activity itself.	Flavonoids	60-69	glutathione S-transferase pi 1	Homo sapiens	166-173
15118327-1	2004	Present study demonstrated that the ethanolic extracts of propolis containing higher concentrations of flavonoids suppressed 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor transformation in a dose-dependent manner.	Flavonoids	103-113	aryl hydrocarbon receptor	Homo sapiens	176-201
15013844-5	2004	Half maximal inhibition of interferon-gamma/lipopolysaccharide induced nitrite accumulation in murine macrophages required about 0.5 mM of the flavonoid.	Flavonoids	143-152	interferon gamma	Mus musculus	27-43
15145447-12	2004	Therefore we assessed, whether the known type II ligand flavonoids interfere with the MIF tautomerase.	Flavonoids	56-66	macrophage migration inhibitory factor	Rattus norvegicus	86-89
15080787-1	2004	OBJECTIVE: Natural flavonoids (plant pigments) have been shown to inhibit thyroid peroxidase (TPO) in vitro and the growth of thyroid cancer cell lines.	Flavonoids	19-29	thyroid peroxidase	Homo sapiens	94-97
15099767-7	2004	Furthermore, SW-ELISA provides the confirmation that flavonoids, the potent antagonists for AhR as reported previously, show the inhibitory effects on TCDD-induced AhR transformation.	Flavonoids	53-63	aryl hydrocarbon receptor	Homo sapiens	92-95
15099767-7	2004	Furthermore, SW-ELISA provides the confirmation that flavonoids, the potent antagonists for AhR as reported previously, show the inhibitory effects on TCDD-induced AhR transformation.	Flavonoids	53-63	aryl hydrocarbon receptor	Homo sapiens	164-167
15019969-3	2004	Flavonoids, and more recently their metabolites, have been reported to act at phosphoinositide 3-kinase (PI 3-kinase), Akt/protein kinase B (Akt/PKB), tyrosine kinases, protein kinase C (PKC), and mitogen activated protein kinase (MAP kinase) signalling cascades.	Flavonoids	0-10	AKT serine/threonine kinase 1	Homo sapiens	119-122
15019969-3	2004	Flavonoids, and more recently their metabolites, have been reported to act at phosphoinositide 3-kinase (PI 3-kinase), Akt/protein kinase B (Akt/PKB), tyrosine kinases, protein kinase C (PKC), and mitogen activated protein kinase (MAP kinase) signalling cascades.	Flavonoids	0-10	protein tyrosine kinase 2 beta	Homo sapiens	123-139
15019969-3	2004	Flavonoids, and more recently their metabolites, have been reported to act at phosphoinositide 3-kinase (PI 3-kinase), Akt/protein kinase B (Akt/PKB), tyrosine kinases, protein kinase C (PKC), and mitogen activated protein kinase (MAP kinase) signalling cascades.	Flavonoids	0-10	AKT serine/threonine kinase 1	Homo sapiens	141-148
15255290-0	2004	Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid.	Flavonoids	110-119	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-66
15255290-5	2004	In addition, we have screened natural flavonoids to find potent inhibitors of [Arg482]ABCG2.	Flavonoids	38-48	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	86-91
15255290-8	2004	In this context, certain flavonoid derivatives are considered to be good candidates for development of ABCG2 inhibitors.	Flavonoids	25-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	103-108
15064367-1	2004	Chalcone synthase, a key regulatory enzyme in the flavonoid pathway, constitutes an eight-member gene family in Glycine max (soybean).	Flavonoids	50-59	chalcone synthase	Glycine max	0-17
15185748-0	2004	Nutritional flavonoids modulate estrogen receptor alpha signaling.	Flavonoids	12-22	estrogen receptor 1	Homo sapiens	32-55
15137505-6	2004	The protective effects of high PAR against elevated UV-B may also be indirect, by increasing leaf thickness and the concentration of flavonoids and other phenolic compounds known to be important in UV screening.	Flavonoids	133-143	jumping translocation breakpoint	Homo sapiens	31-34
14993710-7	2004	A description of the catechol binding contributes to the understanding of lipoxygenase inhibition and the participation of its co-oxidative activity in the utilization of natural flavonoids.	Flavonoids	179-189	linoleate 9S-lipoxygenase-4	Glycine max	74-86
15104253-0	2004	The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.	Flavonoids	100-110	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	23-54
15104253-1	2004	We identified the UDP-glucuronosyltransferase (UGT) 1A1 5"-upstream region that confers UGT1A1 induction by various agents, including flavonoids, on a luciferase reporter gene and has the properties of a transcriptional enhancer.	Flavonoids	134-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-55
15104253-1	2004	We identified the UDP-glucuronosyltransferase (UGT) 1A1 5"-upstream region that confers UGT1A1 induction by various agents, including flavonoids, on a luciferase reporter gene and has the properties of a transcriptional enhancer.	Flavonoids	134-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	88-94
15104253-3	2004	Utilizing transactivation experiments with the UGT1A1 290-bp reporter gene, we assessed UGT1A1 induction by various flavonoids.	Flavonoids	116-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	88-94
15104253-5	2004	The treatment of HepG2 cells with the flavonoids for 24 hr elevated the expression of mRNAs and proteins of UGT1A1 and CYP1A1, while the mRNA levels of CYP2B6, CYP3A4, CAR, PXR and AhR was not altered.	Flavonoids	38-48	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	108-114
15104253-5	2004	The treatment of HepG2 cells with the flavonoids for 24 hr elevated the expression of mRNAs and proteins of UGT1A1 and CYP1A1, while the mRNA levels of CYP2B6, CYP3A4, CAR, PXR and AhR was not altered.	Flavonoids	38-48	nuclear receptor subfamily 1 group I member 3	Homo sapiens	168-171
15104253-5	2004	The treatment of HepG2 cells with the flavonoids for 24 hr elevated the expression of mRNAs and proteins of UGT1A1 and CYP1A1, while the mRNA levels of CYP2B6, CYP3A4, CAR, PXR and AhR was not altered.	Flavonoids	38-48	nuclear receptor subfamily 1 group I member 2	Homo sapiens	173-176
15104253-5	2004	The treatment of HepG2 cells with the flavonoids for 24 hr elevated the expression of mRNAs and proteins of UGT1A1 and CYP1A1, while the mRNA levels of CYP2B6, CYP3A4, CAR, PXR and AhR was not altered.	Flavonoids	38-48	aryl hydrocarbon receptor	Homo sapiens	181-184
15104253-8	2004	Taken together, the results indicate that UGT1A1 was induced in response to flavonoids and xenobiotics through the transactivation of the 290-bp reporter gene, that was a multi-component enhancer containing CAR, PXR and AhR motifs.	Flavonoids	76-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-48
15104253-8	2004	Taken together, the results indicate that UGT1A1 was induced in response to flavonoids and xenobiotics through the transactivation of the 290-bp reporter gene, that was a multi-component enhancer containing CAR, PXR and AhR motifs.	Flavonoids	76-86	nuclear receptor subfamily 1 group I member 3	Homo sapiens	207-210
15104253-8	2004	Taken together, the results indicate that UGT1A1 was induced in response to flavonoids and xenobiotics through the transactivation of the 290-bp reporter gene, that was a multi-component enhancer containing CAR, PXR and AhR motifs.	Flavonoids	76-86	nuclear receptor subfamily 1 group I member 2	Homo sapiens	212-215
15104253-8	2004	Taken together, the results indicate that UGT1A1 was induced in response to flavonoids and xenobiotics through the transactivation of the 290-bp reporter gene, that was a multi-component enhancer containing CAR, PXR and AhR motifs.	Flavonoids	76-86	aryl hydrocarbon receptor	Homo sapiens	220-223
14988518-6	2004	Consistent with this primary observation, the cocoa flavonoid fraction also suppressed human aortic endothelial cell (HAEC) growth and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2.	Flavonoids	52-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	194-199
14988518-6	2004	Consistent with this primary observation, the cocoa flavonoid fraction also suppressed human aortic endothelial cell (HAEC) growth and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2.	Flavonoids	52-61	kinase insert domain receptor	Homo sapiens	219-226
14988518-6	2004	Consistent with this primary observation, the cocoa flavonoid fraction also suppressed human aortic endothelial cell (HAEC) growth and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2.	Flavonoids	52-61	kinase insert domain receptor	Homo sapiens	227-230
14988518-6	2004	Consistent with this primary observation, the cocoa flavonoid fraction also suppressed human aortic endothelial cell (HAEC) growth and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2.	Flavonoids	52-61	mitogen-activated protein kinase 11	Homo sapiens	235-242
14988518-6	2004	Consistent with this primary observation, the cocoa flavonoid fraction also suppressed human aortic endothelial cell (HAEC) growth and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2.	Flavonoids	52-61	mitogen-activated protein kinase 11	Homo sapiens	243-251
14988518-9	2004	These results suggest specific dietary flavonoids are capable of selectively inhibiting ErbB2 and therefore may offer important insight into the design of therapeutic agents that target tumors overexpressing ErbB2.	Flavonoids	39-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-93
14988518-9	2004	These results suggest specific dietary flavonoids are capable of selectively inhibiting ErbB2 and therefore may offer important insight into the design of therapeutic agents that target tumors overexpressing ErbB2.	Flavonoids	39-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	208-213
14985096-0	2004	Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat.	Flavonoids	0-9	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	31-35
14985096-4	2004	Thus, we investigated the effect of quercetin, a flavonoid, on ENaC mRNA expression in the kidney of hypertensive Dahl salt-sensitive rats.	Flavonoids	49-58	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	63-67
14985096-6	2004	Quercetin diminished the alphaENaC mRNA expression in the kidney associated with reduction of the systolic blood pressure elevated by high-salt diet, suggesting that one of the mechanisms of the flavonoid"s antihypertensive effect on salt-sensitive hypertension would be mediated through downregulation of ENaC expression in the kidney.	Flavonoids	195-204	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	30-34
15153159-5	2004	However, troxerutin (a flavonoid) was able to neutralize the downregulatory action of TNF-alpha on the HuIFN-alpha system at low levels and re-establish the antiviral activity ascribed to IFN-alpha.	Flavonoids	23-32	tumor necrosis factor	Homo sapiens	86-95
15153159-5	2004	However, troxerutin (a flavonoid) was able to neutralize the downregulatory action of TNF-alpha on the HuIFN-alpha system at low levels and re-establish the antiviral activity ascribed to IFN-alpha.	Flavonoids	23-32	interferon alpha 1	Homo sapiens	105-114
14980632-0	2004	QSAR study of flavonoid derivatives as p56lck tyrosinkinase inhibitors.	Flavonoids	14-23	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-45
14980632-1	2004	QSAR studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase inhibitors were performed using hydration energy and logP as predictor parameters.	Flavonoids	20-29	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-51
15051172-5	2004	Four different interaction modes were observed, flavonoids are stabilised in S(1) region of beta-trypsin by formation of two (apigenin) or at least one hydrogen bond and other significant electrostatic interactions.	Flavonoids	48-58	serine protease 1	Homo sapiens	92-104
15185748-8	2004	Here, we investigated the possibility that the antimitogenic effects of flavonoids are transduced by modulating ERalpha-mediated rapid signaling.	Flavonoids	72-82	estrogen receptor 1	Homo sapiens	112-119
15185748-9	2004	The ability of two flavonoids, the flavanone naringenin and the flavanol quercetin, with respect of E2, to induce ERalpha activities has been studied in the human cervix epitheloid carcinoma cell line (HeLa) devoid of any estrogen receptors and rendered E2-sensitive by transient transfection with a human ERalpha expression vector.	Flavonoids	19-29	estrogen receptor 1	Homo sapiens	114-121
15185748-10	2004	Our results indicate that flavonoids act as E2 mimetic on ERalpha transcriptional activity, whereas they impair the activation of rapid signaling pathways committed to E2-induced proliferation.	Flavonoids	26-36	estrogen receptor 1	Homo sapiens	58-65
15185748-11	2004	The resulting decoupling of ERalpha signal transduction could be proposed as a new mechanism in the protective effects of flavonoids against E2-related cancer.	Flavonoids	122-132	estrogen receptor 1	Homo sapiens	28-35
14988445-1	2004	Flavonoids have the potential to modulate inflammation by inhibition of cyclooxygenase-2 (COX-2) transcription.	Flavonoids	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-88
15043421-1	2004	A number of natural and synthetic flavonoids have been assessed previously with regard to their effects on the activity of cyclin-dependent kinases (Cdk1 and -2) related to the inhibition of cell cycle progression.	Flavonoids	34-44	cyclin dependent kinase 1	Homo sapiens	149-160
15043421-3	2004	Here we show that some natural flavonoids inhibit the activity of the Cdk5/p35 system in the micromolar range, while others are practically inactive.	Flavonoids	31-41	cyclin dependent kinase 5	Homo sapiens	70-74
15043421-3	2004	Here we show that some natural flavonoids inhibit the activity of the Cdk5/p35 system in the micromolar range, while others are practically inactive.	Flavonoids	31-41	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	75-78
14988445-1	2004	Flavonoids have the potential to modulate inflammation by inhibition of cyclooxygenase-2 (COX-2) transcription.	Flavonoids	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	90-95
14988445-3	2004	We show that the flavonoid quercetin metabolites as detected in human plasma at physiologically significant concentrations inhibit COX-2 expression in human lymphocytes ex vivo.	Flavonoids	17-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	131-136
14725861-1	2004	Anthocyanidin reductase (ANR), encoded by the BANYULS gene, is a newly discovered enzyme of the flavonoid pathway involved in the biosynthesis of condensed tannins.	Flavonoids	96-105	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	46-53
14976232-1	2004	Dihydroflavonol-4-reductase (DFR; EC1.1.1.219) catalyzes a key step late in the biosynthesis of anthocyanins, condensed tannins (proanthocyanidins), and other flavonoids important to plant survival and human nutrition.	Flavonoids	159-169	dihydroflavonol 4-reductase	Medicago truncatula	0-27
15072439-7	2004	Many of these herbal constituents, in particular flavonoids, were reported to modulate Pgp by directly interacting with the vicinal ATP-binding site, the steroid-binding site, or the substrate-binding site.	Flavonoids	49-59	ATP binding cassette subfamily B member 1	Homo sapiens	87-90
14630071-7	2004	Furthermore, total concentrations of flavonoids, fecal- and phytosteroids and resorcyclic lactones were about 1.2 microg/l at STP 1, 0.62 microg/l at STP 2 and 0.25 microg/l at the river Rhine, lane 4.	Flavonoids	37-47	Stp1p	Saccharomyces cerevisiae S288C	126-131
15083379-7	2004	Nonsteroidal aromatase inhibitors can be divided into three classes: aminoglutethimide-like molecules, imidazole/triazole derivatives, and flavonoid analogs.	Flavonoids	139-148	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	13-22
14718498-1	2004	DFR is involved in an important step in the flavonoid biosynthesis pathway upstream of anthocyanin, proanthocyanidin, and phlobaphene production, which contributes to the pigmentation of various plant tissues.	Flavonoids	44-53	DFR	Triticum aestivum	0-3
15084349-7	2004	From these results, it appears that inhibitory effects of flavonoids are due to the combination of steric structure and electron affinity between the active center of 3beta-HSD type II and the flavonoid molecule.	Flavonoids	58-68	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Homo sapiens	167-184
15084349-7	2004	From these results, it appears that inhibitory effects of flavonoids are due to the combination of steric structure and electron affinity between the active center of 3beta-HSD type II and the flavonoid molecule.	Flavonoids	58-67	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Homo sapiens	167-184
14698415-9	2004	This biphasic effect of flavonoids was due to the stimulation or the inhibition of CYP1A2 activity in a dose-dependent manner judging by the activities of EROD or MROD in the Salmonella cells.	Flavonoids	24-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	83-89
14570878-7	2004	In the case of products formed by oxidation of flavonoid substrates with a C-3 hydroxyl group (e.g. (2R,3R)-trans-dihydroquercetin), the results imply that oxygen exchange can occur at a stage subsequent to initial oxidation of the C-ring, probably via an enzyme-bound C-3 ketone/3,3-gem-diol intermediate.	Flavonoids	47-56	complement C3	Homo sapiens	75-78
14570878-7	2004	In the case of products formed by oxidation of flavonoid substrates with a C-3 hydroxyl group (e.g. (2R,3R)-trans-dihydroquercetin), the results imply that oxygen exchange can occur at a stage subsequent to initial oxidation of the C-ring, probably via an enzyme-bound C-3 ketone/3,3-gem-diol intermediate.	Flavonoids	47-56	complement C3	Homo sapiens	269-272
14697053-3	2004	Electrospray ionization results showed that the phosphorylated flavonoids could form noncovalent complexes with many proteins, such as lysozyme, myoglobin, bovine insulin, and cytochrome c, while noncovalent complexes were not detected in the mixed solution of the chrysin and proteins.	Flavonoids	63-73	insulin	Bos taurus	163-170
14684314-0	2004	Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-alpha2b.	Flavonoids	38-48	interferon alpha 2	Homo sapiens	91-109
14697053-3	2004	Electrospray ionization results showed that the phosphorylated flavonoids could form noncovalent complexes with many proteins, such as lysozyme, myoglobin, bovine insulin, and cytochrome c, while noncovalent complexes were not detected in the mixed solution of the chrysin and proteins.	Flavonoids	63-73	LOC104968582	Bos taurus	176-188
14745173-0	2004	A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production.	Flavonoids	20-30	tumor necrosis factor	Mus musculus	98-125
15500064-0	2003	Flavonoids and resveratrol as regulators of Ah-receptor activity: protection from dioxin toxicity.	Flavonoids	0-10	aryl hydrocarbon receptor	Homo sapiens	44-55
14999013-0	2004	Inhibitory effects of flavonoids on animal fatty acid synthase.	Flavonoids	22-32	fatty acid synthase	Homo sapiens	43-62
14999013-1	2004	The inhibitory effects of 15 flavonoids on animal fatty acid synthase (FAS, EC 2.3.1.85) were investigated, and 9 of them were found to inhibit FAS with IC(50) (the inhibitor concentration inhibiting 50% of the activity of FAS) values ranging from 2 to 112 microM.	Flavonoids	29-39	fatty acid synthase	Homo sapiens	50-69
14999013-1	2004	The inhibitory effects of 15 flavonoids on animal fatty acid synthase (FAS, EC 2.3.1.85) were investigated, and 9 of them were found to inhibit FAS with IC(50) (the inhibitor concentration inhibiting 50% of the activity of FAS) values ranging from 2 to 112 microM.	Flavonoids	29-39	fatty acid synthase	Homo sapiens	71-74
14999013-1	2004	The inhibitory effects of 15 flavonoids on animal fatty acid synthase (FAS, EC 2.3.1.85) were investigated, and 9 of them were found to inhibit FAS with IC(50) (the inhibitor concentration inhibiting 50% of the activity of FAS) values ranging from 2 to 112 microM.	Flavonoids	29-39	fatty acid synthase	Homo sapiens	144-147
14999013-1	2004	The inhibitory effects of 15 flavonoids on animal fatty acid synthase (FAS, EC 2.3.1.85) were investigated, and 9 of them were found to inhibit FAS with IC(50) (the inhibitor concentration inhibiting 50% of the activity of FAS) values ranging from 2 to 112 microM.	Flavonoids	29-39	fatty acid synthase	Homo sapiens	144-147
14756776-9	2004	A flavonoid, daidzein was able to induce 18 of the 19 nod-boxes in a NodD1-dependent manner.	Flavonoids	2-11	transcriptional regulator NodD1	Sinorhizobium fredii NGR234	69-74
14756776-12	2004	Activation of transcription of nodD2 is also dependent on flavonoids despite the absence of a nod-box like sequence in the upstream promoter region.	Flavonoids	58-68	transcriptional regulator NodD2	Sinorhizobium fredii NGR234	31-36
14756776-14	2004	Thus, NodD1, NodD2 and SyrM2 co-modulate a flavonoid-inducible regulatory cascade that coordinates the expression of symbiotic genes with nodule development.	Flavonoids	43-52	transcriptional regulator NodD1	Sinorhizobium fredii NGR234	6-11
14756776-14	2004	Thus, NodD1, NodD2 and SyrM2 co-modulate a flavonoid-inducible regulatory cascade that coordinates the expression of symbiotic genes with nodule development.	Flavonoids	43-52	transcriptional regulator NodD2	Sinorhizobium fredii NGR234	13-18
14756776-14	2004	Thus, NodD1, NodD2 and SyrM2 co-modulate a flavonoid-inducible regulatory cascade that coordinates the expression of symbiotic genes with nodule development.	Flavonoids	43-52	LysR family transcriptional regulator	Sinorhizobium fredii NGR234	23-28
15231453-0	2004	Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity.	Flavonoids	0-10	APC, WNT signaling pathway regulator	Mus musculus	88-91
15231453-3	2004	The purpose of this study is to determine whether specific flavonoids induce cell migration in colon epithelial cells either wild type or heterozygous for Apc genotype.	Flavonoids	59-69	APC, WNT signaling pathway regulator	Mus musculus	155-158
15063831-5	2004	Among the main active chemicals of P. cuspidatum, resveratrol, a kind of flavonoid, decreased ACAT activity in a dose-dependent manner from the level of 10(-3) M. Theses results strongly suggest that PCWE reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT.	Flavonoids	73-82	carboxylesterase 1	Homo sapiens	94-98
14664511-3	2003	After content analysis, it was found that CF-H is mainly composed of polyphenols including flavonoids (6.9%), procyanidins (2.2%), (+)-catechin (0.5%), and (-)-epicatechin (0.2%).	Flavonoids	91-101	complement component factor h	Mus musculus	42-46
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Flavonoids	208-218	ATM serine/threonine kinase	Homo sapiens	18-21
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Flavonoids	208-218	ATR serine/threonine kinase	Homo sapiens	22-25
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Flavonoids	208-218	mitogen-activated protein kinase 14	Homo sapiens	30-33
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Flavonoids	208-218	ATM serine/threonine kinase	Homo sapiens	94-97
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Flavonoids	208-218	ATR serine/threonine kinase	Homo sapiens	98-101
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Flavonoids	208-218	mitogen-activated protein kinase 14	Homo sapiens	111-114
14609732-6	2003	The inductions of ATM/ATR and p38 were functionally important since caffeine, an inhibitor of ATM/ATR, and the p38-specific inhibitor, SB203580, prevented induction of GADD45 and growth arrest by these three flavonoids.	Flavonoids	208-218	growth arrest and DNA damage inducible alpha	Homo sapiens	168-174
14646171-0	2003	Inhibition of syk activity and degranulation of human mast cells by flavonoids.	Flavonoids	68-78	spleen associated tyrosine kinase	Homo sapiens	14-17
14646171-1	2003	To investigate the effect of flavonoids on the activation of p72(syk) (Syk) protein tyrosine kinase which plays a pivotal role in the high affinity IgE receptor-mediated degranulation of mast cells, we picked out 10 flavonoids, classified them into 4 series, and examined their effects on the activation of Syk and on the degranulation of human mast cells.	Flavonoids	29-39	spleen associated tyrosine kinase	Homo sapiens	61-69
14646171-1	2003	To investigate the effect of flavonoids on the activation of p72(syk) (Syk) protein tyrosine kinase which plays a pivotal role in the high affinity IgE receptor-mediated degranulation of mast cells, we picked out 10 flavonoids, classified them into 4 series, and examined their effects on the activation of Syk and on the degranulation of human mast cells.	Flavonoids	29-39	spleen associated tyrosine kinase	Homo sapiens	71-74
14646171-1	2003	To investigate the effect of flavonoids on the activation of p72(syk) (Syk) protein tyrosine kinase which plays a pivotal role in the high affinity IgE receptor-mediated degranulation of mast cells, we picked out 10 flavonoids, classified them into 4 series, and examined their effects on the activation of Syk and on the degranulation of human mast cells.	Flavonoids	216-226	spleen associated tyrosine kinase	Homo sapiens	61-69
14646171-1	2003	To investigate the effect of flavonoids on the activation of p72(syk) (Syk) protein tyrosine kinase which plays a pivotal role in the high affinity IgE receptor-mediated degranulation of mast cells, we picked out 10 flavonoids, classified them into 4 series, and examined their effects on the activation of Syk and on the degranulation of human mast cells.	Flavonoids	216-226	spleen associated tyrosine kinase	Homo sapiens	71-74
14646171-4	2003	A significant relationship was observed between the inhibition of Syk activity and HCMC degranulation attributable to flavonoids when the ClogP values of the compounds were taken into account (r(2)=0.89).	Flavonoids	118-128	spleen associated tyrosine kinase	Homo sapiens	66-69
14646171-5	2003	These results suggested that the impairment of mast cell degranulation by several flavonoids classified into flavones and flavonols might be mediated via inhibition of the intracellular activation of Syk.	Flavonoids	82-92	spleen associated tyrosine kinase	Homo sapiens	200-203
14742143-0	2003	Inhibition of rat liver sulfotransferases SULT1A1 and SULT2A1 and glucuronosyltransferase by dietary flavonoids.	Flavonoids	101-111	sulfotransferase family 1A member 1	Rattus norvegicus	42-49
14669262-0	2003	Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.	Flavonoids	30-40	selectin E	Homo sapiens	44-54
14669262-0	2003	Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.	Flavonoids	30-40	tumor necrosis factor	Homo sapiens	122-149
14669262-1	2003	The present study investigates the suppressive effect of flavonoids on TNF-alpha-stimulated E-selectin expression on HUVECs by carrying out a comparative examination of the 37 flavonoids.	Flavonoids	57-67	tumor necrosis factor	Homo sapiens	71-80
14669262-1	2003	The present study investigates the suppressive effect of flavonoids on TNF-alpha-stimulated E-selectin expression on HUVECs by carrying out a comparative examination of the 37 flavonoids.	Flavonoids	57-67	selectin E	Homo sapiens	92-102
14669262-1	2003	The present study investigates the suppressive effect of flavonoids on TNF-alpha-stimulated E-selectin expression on HUVECs by carrying out a comparative examination of the 37 flavonoids.	Flavonoids	176-186	tumor necrosis factor	Homo sapiens	71-80
14644660-0	2003	Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.	Flavonoids	0-10	aryl hydrocarbon receptor	Homo sapiens	14-39
14644660-2	2003	In this study we investigated the AhR agonist/antagonist activities of the following flavonoids: chrysin, phloretin, kaempferol, galangin, naringenin, genistein, quercetin, myricetin, luteolin, baicalein, daidzein, apigenin, and diosmin.	Flavonoids	85-95	aryl hydrocarbon receptor	Homo sapiens	34-37
14742143-0	2003	Inhibition of rat liver sulfotransferases SULT1A1 and SULT2A1 and glucuronosyltransferase by dietary flavonoids.	Flavonoids	101-111	sulfotransferase family 2A member 1	Rattus norvegicus	54-61
14742143-4	2003	All four flavonoids inhibited the sulfonation of E(2) via phenol sulfotransferase, SULT1A1 with IC(50)s ranging from 0.29 to 4.61 micro M. Sulfonation of dehydroisoandrosterone (DHEA) via hydroxysteroid sulfotransferase, SULT2A1, was inhibited by higher amounts of the flavonoids (IC(50)s ranging from 34 to 116 micro M).	Flavonoids	9-19	sulfotransferase family 1A member 1	Rattus norvegicus	83-90
14742143-4	2003	All four flavonoids inhibited the sulfonation of E(2) via phenol sulfotransferase, SULT1A1 with IC(50)s ranging from 0.29 to 4.61 micro M. Sulfonation of dehydroisoandrosterone (DHEA) via hydroxysteroid sulfotransferase, SULT2A1, was inhibited by higher amounts of the flavonoids (IC(50)s ranging from 34 to 116 micro M).	Flavonoids	9-19	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Rattus norvegicus	188-219
14742143-4	2003	All four flavonoids inhibited the sulfonation of E(2) via phenol sulfotransferase, SULT1A1 with IC(50)s ranging from 0.29 to 4.61 micro M. Sulfonation of dehydroisoandrosterone (DHEA) via hydroxysteroid sulfotransferase, SULT2A1, was inhibited by higher amounts of the flavonoids (IC(50)s ranging from 34 to 116 micro M).	Flavonoids	9-19	sulfotransferase family 2A member 1	Rattus norvegicus	221-228
14742143-4	2003	All four flavonoids inhibited the sulfonation of E(2) via phenol sulfotransferase, SULT1A1 with IC(50)s ranging from 0.29 to 4.61 micro M. Sulfonation of dehydroisoandrosterone (DHEA) via hydroxysteroid sulfotransferase, SULT2A1, was inhibited by higher amounts of the flavonoids (IC(50)s ranging from 34 to 116 micro M).	Flavonoids	269-279	sulfotransferase family 1A member 1	Rattus norvegicus	83-90
14742143-10	2003	It is concluded that SULT1A1 but not SULT2A1 or glucuronosyltransferase is highly sensitive to inhibition by dietary flavonoids.	Flavonoids	117-127	sulfotransferase family 1A member 1	Rattus norvegicus	21-28
14742143-11	2003	The potency of the inhibition for SULT1A1 (quercetin &gt; kaempferol &gt; genistein &gt; daidzein) suggests a dependency on the number and position of hydroxyl radicals in the flavonoid molecule.	Flavonoids	176-185	sulfotransferase family 1A member 1	Rattus norvegicus	34-41
14563492-7	2003	Pretreatment of the HO-1 inhibitor, tin protoporphyrin (10 microM), attenuated the inhibitory activities of the indicated flavonoids on LPS-induced NO production.	Flavonoids	122-132	heme oxygenase 1	Mus musculus	20-24
14563492-7	2003	Pretreatment of the HO-1 inhibitor, tin protoporphyrin (10 microM), attenuated the inhibitory activities of the indicated flavonoids on LPS-induced NO production.	Flavonoids	122-132	toll-like receptor 4	Mus musculus	136-139
14563492-0	2003	Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1.	Flavonoids	68-78	heme oxygenase 1	Mus musculus	112-128
14563492-13	2003	These results provide evidence on the role of HO-1 in the inhibition of LPS-induced NO production by flavonoids.	Flavonoids	101-111	heme oxygenase 1	Mus musculus	46-50
14563492-1	2003	The role of heme oxygenase-1 (HO-1) played in the inhibitory mechanism of flavonoids in lipopolysaccharide (LPS)-induced responses remained unresolved.	Flavonoids	74-84	heme oxygenase 1	Mus musculus	12-28
14563492-13	2003	These results provide evidence on the role of HO-1 in the inhibition of LPS-induced NO production by flavonoids.	Flavonoids	101-111	toll-like receptor 4	Mus musculus	72-75
14563492-1	2003	The role of heme oxygenase-1 (HO-1) played in the inhibitory mechanism of flavonoids in lipopolysaccharide (LPS)-induced responses remained unresolved.	Flavonoids	74-84	heme oxygenase 1	Mus musculus	30-34
14563492-1	2003	The role of heme oxygenase-1 (HO-1) played in the inhibitory mechanism of flavonoids in lipopolysaccharide (LPS)-induced responses remained unresolved.	Flavonoids	74-84	toll-like receptor 4	Mus musculus	108-111
14563492-14	2003	A combination of HO-1 inducers (i.e. hemin) and flavonoids might be an effective strategy for the suppression of LPS-induced NO production.	Flavonoids	48-58	toll-like receptor 4	Mus musculus	113-116
14563492-2	2003	In the present study, flavonoids, including 3-OH flavone, baicalein, kaempferol, and quercetin, induced HO-1 gene expression at the protein and mRNA levels in the presence or absence of LPS in RAW264.7 macrophages.	Flavonoids	22-32	heme oxygenase 1	Mus musculus	104-108
14570756-1	2003	Phloridzin, a glucoside of the flavonoid-like polyphenol phloretin, has long been known to be a specific nontransportable inhibitor of the sodium-dependent glucose transporter SGLT1.	Flavonoids	31-40	solute carrier family 5 member 1	Canis lupus familiaris	176-181
14563492-2	2003	In the present study, flavonoids, including 3-OH flavone, baicalein, kaempferol, and quercetin, induced HO-1 gene expression at the protein and mRNA levels in the presence or absence of LPS in RAW264.7 macrophages.	Flavonoids	22-32	toll-like receptor 4	Mus musculus	186-189
14563492-6	2003	Hemin, at the doses of 10, 20, and 50 microM, dose-dependently stimulated the flavonoid (50 microM)-induced HO-1 protein expression, and enhanced their inhibitory effects on LPS-induced NO production and iNOS protein expression.	Flavonoids	78-87	heme oxygenase 1	Mus musculus	108-112
14563492-6	2003	Hemin, at the doses of 10, 20, and 50 microM, dose-dependently stimulated the flavonoid (50 microM)-induced HO-1 protein expression, and enhanced their inhibitory effects on LPS-induced NO production and iNOS protein expression.	Flavonoids	78-87	nitric oxide synthase 2, inducible	Mus musculus	204-208
14570756-12	2003	In addition, they demonstrate that this and other flavonoid glycosides unexpectedly are efficiently effluxed by both MRP1 and MRP2.	Flavonoids	50-59	ATP binding cassette subfamily C member 1	Canis lupus familiaris	117-121
14570756-12	2003	In addition, they demonstrate that this and other flavonoid glycosides unexpectedly are efficiently effluxed by both MRP1 and MRP2.	Flavonoids	50-59	ATP binding cassette subfamily C member 2	Canis lupus familiaris	126-130
14618263-0	2003	Multiple flavonoid-binding sites within multidrug resistance protein MRP1.	Flavonoids	9-18	ATP binding cassette subfamily C member 1	Homo sapiens	69-73
14617075-0	2003	Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids.	Flavonoids	116-126	glutathione S-transferase PHI 2	Arabidopsis thaliana	12-19
14617075-0	2003	Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids.	Flavonoids	116-126	glutathione S-transferase PHI 10	Arabidopsis thaliana	70-95
14617075-6	2003	As NPA may act as an endogenous flavonoid regulator of auxin transport, competition between NPA and flavonoids for binding to AtGSTF2 was examined.	Flavonoids	100-110	glutathione S-transferase PHI 2	Arabidopsis thaliana	126-133
12970578-0	2003	Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells.	Flavonoids	8-18	pyruvate carboxylase	Homo sapiens	28-31
12970578-0	2003	Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells.	Flavonoids	8-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
12970578-0	2003	Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells.	Flavonoids	8-18	aryl hydrocarbon receptor	Homo sapiens	80-83
14519939-0	2003	Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids.	Flavonoids	136-146	vascular endothelial growth factor A	Homo sapiens	80-114
14519939-0	2003	Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids.	Flavonoids	136-146	vascular endothelial growth factor A	Homo sapiens	116-120
14618263-1	2003	Recombinant nucleotide-binding domains (NBDs) from human multidrug resistance protein MRP1 were overexpressed in bacteria and purified to measure their direct interaction with high-affinity flavonoids, and to evaluate a potential correlation with inhibition of MRP1-mediated transport activity and reversion of cellular multidrug resistance.	Flavonoids	190-200	ATP binding cassette subfamily C member 1	Homo sapiens	86-90
12928578-1	2003	Flavonoids, naturally occurring polyphenolic compounds, are known to inhibit both lipopolysaccharide (LPS) stimulated tumor necrosis factor alpha and interleukin 6 release which modulate the proinflammatory molecules that have been reported in many progressive neurodegenerative disorders, including Alzheimer"s disease (AD), viral and bacterial meningitis, AIDS dementia complex, and stroke.	Flavonoids	0-10	tumor necrosis factor	Mus musculus	118-145
14514640-0	2003	Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation.	Flavonoids	70-79	apolipoprotein B	Homo sapiens	29-45
12928578-10	2003	The results showed that chronic treatment with flavonoids reverses cognitive deficits in aged and LPS-intoxicated mice which suggests that modulation of cyclooxygenase-2 and inducible nitric synthase by flavonoids may be important in the prevention of memory deficits, one of the symptoms related to AD.	Flavonoids	47-57	prostaglandin-endoperoxide synthase 2	Mus musculus	153-169
12928578-10	2003	The results showed that chronic treatment with flavonoids reverses cognitive deficits in aged and LPS-intoxicated mice which suggests that modulation of cyclooxygenase-2 and inducible nitric synthase by flavonoids may be important in the prevention of memory deficits, one of the symptoms related to AD.	Flavonoids	203-213	prostaglandin-endoperoxide synthase 2	Mus musculus	153-169
12927873-6	2003	The most potent new analogue, UCCF-339, activated wild-type CFTR with a K(d) of 1.7 microM, which is more active than the previous most potent flavonoid activator of CFTR, apigenin.	Flavonoids	143-152	CF transmembrane conductance regulator	Homo sapiens	166-170
14756320-9	2003	The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation.	Flavonoids	238-247	transcription factor MYB101	Glycine max	112-118
14756320-9	2003	The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation.	Flavonoids	238-247	chalcone synthase 3	Glycine max	147-150
14756320-9	2003	The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation.	Flavonoids	238-247	transcription factor MYB101	Glycine max	214-220
12761503-0	2003	Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Calpha.	Flavonoids	0-9	Fas cell surface death receptor	Homo sapiens	33-37
12741958-6	2003	The assay confirmed that caffeic acid as the preferred substrate when compared with other hydroxycinnamates, although UGT71C1 also exhibited substantial activity towards flavonoid substrates, known to have structural features that can be recognized by many different UGTs.	Flavonoids	170-179	UDP-glucosyl transferase 71C1	Arabidopsis thaliana	118-125
12911599-5	2003	Treatment with the flavonoids quercetin or catechin reduced PS exposure, thrombin formation, PIP2 level and resynthesis after platelet activation with collagen, thrombin or calcium ionophore.	Flavonoids	19-29	coagulation factor II, thrombin	Homo sapiens	73-81
12911599-5	2003	Treatment with the flavonoids quercetin or catechin reduced PS exposure, thrombin formation, PIP2 level and resynthesis after platelet activation with collagen, thrombin or calcium ionophore.	Flavonoids	19-29	coagulation factor II, thrombin	Homo sapiens	161-169
12948016-1	2003	PURPOSE: The purpose of this study was to investigate the effects of flavonoids biochanin A and silymarin on intestinal absorption of P-gp substrates by determining their effects on P-gp-mediated efflux in Caco-2 cells.	Flavonoids	69-79	phosphoglycolate phosphatase	Homo sapiens	134-138
12697024-7	2003	GNMT phosphorylation could be suppressed by naringin, an okadaic acid-antagonistic flavonoid.	Flavonoids	83-92	glycine N-methyltransferase	Rattus norvegicus	0-4
12949627-0	2003	Molecular basis of Fas and cytochrome c pathways of apoptosis induced by tartary buckwheat flavonoid in HL-60 cells.	Flavonoids	91-100	cytochrome c, somatic	Homo sapiens	27-39
12761886-0	2003	Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.	Flavonoids	0-10	vascular endothelial growth factor A	Homo sapiens	19-23
12761886-0	2003	Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.	Flavonoids	0-10	fibroblast growth factor 2	Homo sapiens	24-28
12761886-5	2003	However, pretreatment with flavonoids before VEGF/bFGF stimulation completely abolished the VEGF/bFGF-stimulated increase in MMP-1 and MT1-MMP expression and pro-MMP-2 activation.	Flavonoids	27-37	vascular endothelial growth factor A	Homo sapiens	92-96
12761886-5	2003	However, pretreatment with flavonoids before VEGF/bFGF stimulation completely abolished the VEGF/bFGF-stimulated increase in MMP-1 and MT1-MMP expression and pro-MMP-2 activation.	Flavonoids	27-37	fibroblast growth factor 2	Homo sapiens	97-101
12761886-5	2003	However, pretreatment with flavonoids before VEGF/bFGF stimulation completely abolished the VEGF/bFGF-stimulated increase in MMP-1 and MT1-MMP expression and pro-MMP-2 activation.	Flavonoids	27-37	matrix metallopeptidase 1	Homo sapiens	125-130
12761886-5	2003	However, pretreatment with flavonoids before VEGF/bFGF stimulation completely abolished the VEGF/bFGF-stimulated increase in MMP-1 and MT1-MMP expression and pro-MMP-2 activation.	Flavonoids	27-37	matrix metallopeptidase 14	Homo sapiens	135-142
12761886-5	2003	However, pretreatment with flavonoids before VEGF/bFGF stimulation completely abolished the VEGF/bFGF-stimulated increase in MMP-1 and MT1-MMP expression and pro-MMP-2 activation.	Flavonoids	27-37	matrix metallopeptidase 2	Homo sapiens	162-167
12711835-3	2003	Quercetin, a flavonoid present in many plants, is reported to inhibit COMT and MAO activities, the key enzymes involved in the metabolism of dopamine.	Flavonoids	13-22	catechol-O-methyltransferase	Rattus norvegicus	70-74
12711835-3	2003	Quercetin, a flavonoid present in many plants, is reported to inhibit COMT and MAO activities, the key enzymes involved in the metabolism of dopamine.	Flavonoids	13-22	monoamine oxidase A	Rattus norvegicus	79-82
12956529-9	2003	The CDNB-conjugating activity of TaGSTF1, and to a lesser extent TaGSTF6, was highly sensitive to inhibition by flavonoids, particularly the chalcone isoliquiritigenin.	Flavonoids	112-122	glutathione S-transferase 1	Triticum aestivum	33-40
12761503-5	2003	Treatment of HPB-ALL cells with quercetin slightly decreased PKCalpha activity, but when the flavonoid was associated with anti-CD95, the kinase activity increased by 12-fold with respect to the treatment with quercetin.	Flavonoids	93-102	Fas cell surface death receptor	Homo sapiens	128-132
12873450-1	2003	The objective of the study was to investigate the effects of baicalin, baicalein, and wogonin (plant flavonoids) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production, mRNA expression, and nuclear factor-kappaB (NF-kappaB) binding activities induced by interleukin-1beta (IL-1beta) in human retinal pigment epithelial cell line (ARPE-19) cells.	Flavonoids	101-111	interleukin 6	Homo sapiens	116-129
12873450-1	2003	The objective of the study was to investigate the effects of baicalin, baicalein, and wogonin (plant flavonoids) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production, mRNA expression, and nuclear factor-kappaB (NF-kappaB) binding activities induced by interleukin-1beta (IL-1beta) in human retinal pigment epithelial cell line (ARPE-19) cells.	Flavonoids	101-111	interleukin 6	Homo sapiens	131-135
12828569-12	2003	Overall the presented observations suggest major involvement of CYP1A2 in the hepatic metabolism of these two flavonoids.	Flavonoids	110-120	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	64-70
12939046-4	2003	Both the oxidation potential and the concentration of L-5-HTP in H. heliophila correspond to the values observed for flavonoids being major antioxidants in plants.	Flavonoids	117-127	ribosomal protein L5	Homo sapiens	54-61
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Flavonoids	71-80	heat shock transcription factor 1	Homo sapiens	118-122
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Flavonoids	71-80	plasminogen activator, urokinase	Homo sapiens	159-162
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Flavonoids	71-80	interleukin 6	Homo sapiens	118-121
12747785-0	2003	Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues.	Flavonoids	62-71	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
12747785-1	2003	Flavonoid derivatives were synthesized and tested for their ability to modulate P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) in vitro.	Flavonoids	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	80-94
12747785-1	2003	Flavonoid derivatives were synthesized and tested for their ability to modulate P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) in vitro.	Flavonoids	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	96-99
12702688-5	2003	During the isolation of mutants, two new classes of flavonoid mutants (tt18, tt19) were isolated from carbon-ion-mutagenized M2 plants.	Flavonoids	52-61	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	71-75
12695340-3	2003	We used primary cultures of human hepatocytes from 17 individuals to assess the inducibility of CYP3A4 mRNA by prototypical inducers, dietary flavonoids, and botanicals.	Flavonoids	142-152	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-102
12686490-1	2003	In the present study, the inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by the flavonoid quercetin has been investigated.	Flavonoids	94-103	glutathione S-transferase pi 1	Homo sapiens	78-85
14518609-0	2003	Flavonoid treatment in patients with healed venous ulcer: flow cytometry analysis suggests increased CD11b expression on neutrophil granulocytes in the circulation.	Flavonoids	0-9	integrin subunit alpha M	Homo sapiens	101-106
14518609-8	2003	Expression of CD11b adhesion molecules on granulocytes was significantly up-regulated (p = 0.044) after treatment with flavonoids for one month, but this increase was not significant (p = 0.056) two months after the treatment period compared with the baseline level.	Flavonoids	119-129	integrin subunit alpha M	Homo sapiens	14-19
14518609-12	2003	It was concluded that flavonoid treatment for 30 days increased the expression of CD11b adhesion molecules on circulating granulocytes.	Flavonoids	22-31	integrin subunit alpha M	Homo sapiens	82-87
12673038-4	2003	Among them, isoflavones such as daidzein, resveratrol having a stilbene structure, and some flavonoids such as naringenin, hesperetin, and baicalein showed AhR activation.	Flavonoids	92-102	aryl hydrocarbon receptor	Homo sapiens	156-159
12702688-5	2003	During the isolation of mutants, two new classes of flavonoid mutants (tt18, tt19) were isolated from carbon-ion-mutagenized M2 plants.	Flavonoids	52-61	glutathione S-transferase phi 12	Arabidopsis thaliana	77-81
12517755-10	2003	The flavonoid quercetin inhibits both AlkB and the 2OG oxygenase factor-inhibiting hypoxia-inducible factor (FIH) in vitro.	Flavonoids	4-13	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	38-42
12644593-9	2003	Together, these data suggest that the differential agonist/antagonist activity of these flavone derivatives is caused by the efficacy of these flavonoids in eliciting an AhR conformation that recognizes regulatory response elements in a species-specific manner.	Flavonoids	143-153	aryl-hydrocarbon receptor	Mus musculus	170-173
12947714-0	2003	[The inhibitory effect of total flavonoids of hippophae on the activation of NF-kappa B by stretching cultured cardiac myocytes].	Flavonoids	32-42	nuclear factor kappa B subunit 1	Homo sapiens	77-87
12672908-10	2003	The antiapoptotic activity of flavonoids appears to be mediated at the mitochondrial bcl-2 and bax gene level.	Flavonoids	30-40	BCL2 apoptosis regulator	Homo sapiens	85-90
12672908-10	2003	The antiapoptotic activity of flavonoids appears to be mediated at the mitochondrial bcl-2 and bax gene level.	Flavonoids	30-40	BCL2 associated X, apoptosis regulator	Homo sapiens	95-98
12644593-0	2003	Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.	Flavonoids	55-65	aryl-hydrocarbon receptor	Mus musculus	142-167
12604704-0	2003	Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport.	Flavonoids	15-25	ATP binding cassette subfamily B member 1	Homo sapiens	74-88
12628496-6	2003	The flavonoid structure appeared to be essential for observed effects as flavonoids containing hydroxyl groups at the B-3 and B-4 positions in combination with a C-2,3 double bond were most effective.	Flavonoids	4-13	immunoglobulin kappa variable 4-1	Homo sapiens	118-129
12628496-6	2003	The flavonoid structure appeared to be essential for observed effects as flavonoids containing hydroxyl groups at the B-3 and B-4 positions in combination with a C-2,3 double bond were most effective.	Flavonoids	73-83	immunoglobulin kappa variable 4-1	Homo sapiens	118-129
12604704-2	2003	The objective of this investigation was to characterize the effect of flavonoids on P-glycoprotein (P-gp)-mediated cellular efflux and to determine the molecular mechanism(s) of the flavonoid-drug interaction.	Flavonoids	70-80	ATP binding cassette subfamily B member 1	Homo sapiens	84-98
12604704-2	2003	The objective of this investigation was to characterize the effect of flavonoids on P-glycoprotein (P-gp)-mediated cellular efflux and to determine the molecular mechanism(s) of the flavonoid-drug interaction.	Flavonoids	70-80	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
12604704-2	2003	The objective of this investigation was to characterize the effect of flavonoids on P-glycoprotein (P-gp)-mediated cellular efflux and to determine the molecular mechanism(s) of the flavonoid-drug interaction.	Flavonoids	70-79	ATP binding cassette subfamily B member 1	Homo sapiens	84-98
12604704-2	2003	The objective of this investigation was to characterize the effect of flavonoids on P-glycoprotein (P-gp)-mediated cellular efflux and to determine the molecular mechanism(s) of the flavonoid-drug interaction.	Flavonoids	70-79	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
12604704-4	2003	The potential mechanism(s) involved in the interaction was evaluated by determining flavonoid effects on 1) P-gp ATPase activity, 2) [(3)H]azidopine photoaffinity labeling of P-gp, and 3) cellular P-gp levels.	Flavonoids	84-93	ATP binding cassette subfamily B member 1	Homo sapiens	108-112
12604704-5	2003	The flavonoids increased [(3)H]DNM accumulation in P-gp positive cells, but not P-gp negative cells, and these effects were both flavonoid concentration- and P-gp expression level-dependent.	Flavonoids	4-14	ATP binding cassette subfamily B member 1	Homo sapiens	51-55
12604704-5	2003	The flavonoids increased [(3)H]DNM accumulation in P-gp positive cells, but not P-gp negative cells, and these effects were both flavonoid concentration- and P-gp expression level-dependent.	Flavonoids	4-13	ATP binding cassette subfamily B member 1	Homo sapiens	51-55
12604704-5	2003	The flavonoids increased [(3)H]DNM accumulation in P-gp positive cells, but not P-gp negative cells, and these effects were both flavonoid concentration- and P-gp expression level-dependent.	Flavonoids	4-13	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
12604704-5	2003	The flavonoids increased [(3)H]DNM accumulation in P-gp positive cells, but not P-gp negative cells, and these effects were both flavonoid concentration- and P-gp expression level-dependent.	Flavonoids	4-13	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
12604704-7	2003	Biochanin A and phloretin stimulated, whereas morin and silymarin inhibited P-gp ATPase activity, confirming that these flavonoids interact with P-gp.	Flavonoids	120-130	ATP binding cassette subfamily B member 1	Homo sapiens	76-80
12604704-7	2003	Biochanin A and phloretin stimulated, whereas morin and silymarin inhibited P-gp ATPase activity, confirming that these flavonoids interact with P-gp.	Flavonoids	120-130	ATP binding cassette subfamily B member 1	Homo sapiens	145-149
12604704-11	2003	The findings of this study indicate a potential for significant flavonoid-drug interactions with P-gp substrates.	Flavonoids	64-73	ATP binding cassette subfamily B member 1	Homo sapiens	97-101
12606047-2	2003	The oxidation of LDL was inhibited by micromolar concentrations of flavonoids such as (-)-epicatechin, quercetin, rutin, taxifolin and luteolin, presumably via scavenging of the MPO-derived NO(2) radical.	Flavonoids	67-77	myeloperoxidase	Homo sapiens	178-181
12644159-0	2003	Phase I study of oral bioflavonoids in cadaveric renal transplant recipients: effects on delayed graft function and calcineurin inhibitor toxicities.	Flavonoids	22-35	calcineurin binding protein 1	Homo sapiens	116-137
12644647-0	2003	A cluster of genes encodes the two types of chalcone isomerase involved in the biosynthesis of general flavonoids and legume-specific 5-deoxy(iso)flavonoids in Lotus japonicus.	Flavonoids	103-113	Chalcone--flavonone isomerase 1	Lotus japonicus	44-62
12644647-0	2003	A cluster of genes encodes the two types of chalcone isomerase involved in the biosynthesis of general flavonoids and legume-specific 5-deoxy(iso)flavonoids in Lotus japonicus.	Flavonoids	146-156	Chalcone--flavonone isomerase 1	Lotus japonicus	44-62
12644647-2	2003	Together with chalcone polyketide reductase and cytochrome P450 2-hydroxyisoflavanone synthase, the chalcone isomerase (CHI) of leguminous plants is fundamental in the construction of these ecophysiologically active flavonoids.	Flavonoids	216-226	Chalcone--flavonone isomerase 1	Lotus japonicus	100-118
12644647-2	2003	Together with chalcone polyketide reductase and cytochrome P450 2-hydroxyisoflavanone synthase, the chalcone isomerase (CHI) of leguminous plants is fundamental in the construction of these ecophysiologically active flavonoids.	Flavonoids	216-226	Chalcone--flavonone isomerase 1	Lotus japonicus	120-123
12523967-0	2003	Modification of flavonoid using lipase in non-conventional media: effect of the water content.	Flavonoids	16-25	PAN0_003d1715	Moesziomyces antarcticus	32-38
12606047-0	2003	Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids.	Flavonoids	95-105	myeloperoxidase	Homo sapiens	0-15
12606047-3	2003	The flavonoids served as substrates of MPO leading to products with distinct absorbance spectra.	Flavonoids	4-14	myeloperoxidase	Homo sapiens	39-42
12606047-4	2003	The MPO-catalyzed oxidation of flavonoids was accelerated in the presence of nitrite.	Flavonoids	31-41	myeloperoxidase	Homo sapiens	4-7
12527341-8	2003	These results show that HepG2 cells can absorb and turnover quercetin glucuronides and that human endogenous beta-glucuronidase activity could modulate the intracellular biological activities of dietary antioxidant flavonoids.	Flavonoids	215-225	glucuronidase beta	Homo sapiens	109-127
12564931-0	2003	Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation.	Flavonoids	80-89	apolipoprotein B	Homo sapiens	11-15
12564931-0	2003	Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation.	Flavonoids	80-89	metallothionein 1B	Homo sapiens	121-124
12527338-0	2003	Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods.	Flavonoids	27-36	albumin	Homo sapiens	57-70
12485947-10	2003	Our results suggest that flavonoids stimulate MRP1-mediated GSH transport by increasing the apparent affinity of the transporter for GSH but provide no evidence that a cotransport mechanism is involved.	Flavonoids	25-35	ATP binding cassette subfamily B member 1	Homo sapiens	46-50
12576520-5	2003	However, the preincubation of H2O2-treated EC with the flavonoids hesperedin, naringin, and quercetin strongly inhibited AT activity and activated TAL by 290%, 340%, and 250%, respectively.	Flavonoids	55-65	transaldolase 1	Homo sapiens	147-150
12576520-6	2003	The induction of TAL activity resulted in enhanced biosynthesis of 1-acyl-2-[3H]acetyl-PAF in intact EC and was related to the flavonoid structure.	Flavonoids	127-136	transaldolase 1	Homo sapiens	17-20
12576520-6	2003	The induction of TAL activity resulted in enhanced biosynthesis of 1-acyl-2-[3H]acetyl-PAF in intact EC and was related to the flavonoid structure.	Flavonoids	127-136	PCNA clamp associated factor	Homo sapiens	87-90
12576520-7	2003	These findings suggest that TAL is involved in the flavonoid anti-inflammatory action by enhancing the production of acyl-PAF.	Flavonoids	51-60	transaldolase 1	Homo sapiens	28-31
12576520-7	2003	These findings suggest that TAL is involved in the flavonoid anti-inflammatory action by enhancing the production of acyl-PAF.	Flavonoids	51-60	PCNA clamp associated factor	Homo sapiens	122-125
14506001-2	2003	A recent innovation has led to the recovery and concentration of water-soluble antioxidants from palm oil milling waste, characterized by its high content of phenolic acids and flavonoids.	Flavonoids	177-187	paralemmin	Homo sapiens	97-101
14506001-9	2003	A relatively new output from the oil palm fruit is the water-soluble phenolic-flavonoid-rich antioxidant complex.	Flavonoids	78-87	paralemmin	Homo sapiens	37-41
12576520-0	2003	Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress.	Flavonoids	14-24	PCNA clamp associated factor	Homo sapiens	28-31
12532374-0	2003	Effect of flavonoids on MRP1-mediated transport in Panc-1 cells.	Flavonoids	10-20	ATP binding cassette subfamily C member 1	Homo sapiens	24-28
12532374-1	2003	The purpose of this study was to identify the effects of dietary flavonoids, which are present in fruits, vegetables, and plant-derived beverages, on the transport of daunomycin (DNM) and vinblastine (VBL) in Panc-1 cells.	Flavonoids	65-75	dynamin 1	Homo sapiens	179-182
12532374-9	2003	These results therefore indicate that the flavonoids morin, chalcone, silymarin, phloretin, genistein, quercetin, biochanin A, and kaempferol can inhibit MRP1-mediated drug transport, effects that may involve binding interactions with MRP1, as well as modulation of GSH concentrations.	Flavonoids	42-52	ATP binding cassette subfamily C member 1	Homo sapiens	154-158
12532374-9	2003	These results therefore indicate that the flavonoids morin, chalcone, silymarin, phloretin, genistein, quercetin, biochanin A, and kaempferol can inhibit MRP1-mediated drug transport, effects that may involve binding interactions with MRP1, as well as modulation of GSH concentrations.	Flavonoids	42-52	ATP binding cassette subfamily C member 1	Homo sapiens	235-239
12586894-2	2003	The Arabidopsis icx1 (increased chalcone synthase expression 1) mutant has elevated induction of CHS (CHALCONE SYNTHASE) and other flavonoid biosynthesis genes in response to several stimuli.	Flavonoids	131-140	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	32-49
12532018-0	2003	Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.	Flavonoids	61-70	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	44-51
12485947-0	2003	Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).	Flavonoids	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	65-95
12485947-0	2003	Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).	Flavonoids	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	97-101
12485947-4	2003	Previous studies have shown that various dietary flavonoids stimulate the ATPase activity of MRP1 and inhibit transport of its conjugated organic anion substrates but are poor reversers of MRP1-mediated drug resistance.	Flavonoids	49-59	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
12485947-4	2003	Previous studies have shown that various dietary flavonoids stimulate the ATPase activity of MRP1 and inhibit transport of its conjugated organic anion substrates but are poor reversers of MRP1-mediated drug resistance.	Flavonoids	49-59	ATP binding cassette subfamily B member 1	Homo sapiens	189-193
12594539-12	2003	CONCLUSIONS: The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial beta-glucosidases (LPH and CBG).	Flavonoids	39-48	lactase	Homo sapiens	161-164
12485947-5	2003	In contrast, many of the same flavonoids markedly stimulate GSH transport by MRP1.	Flavonoids	30-40	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
12594539-12	2003	CONCLUSIONS: The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial beta-glucosidases (LPH and CBG).	Flavonoids	39-48	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	169-172
12812360-8	2003	Our results indicate that flavonoid molecular structure provides a promising base for development of potent MRP1 inhibitors.	Flavonoids	26-35	ATP binding cassette subfamily C member 1	Homo sapiens	108-112
14689067-5	2003	Significant inhibition of GR activity was observed when flavonoids were used in concentrations higher than 25 microM.	Flavonoids	56-66	glutathione reductase	Mus musculus	26-28
12812360-0	2003	Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes.	Flavonoids	0-10	ATP binding cassette subfamily C member 1	Homo sapiens	28-32
14977446-0	2003	Inhibitory effect of some flavonoids on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated mouse macrophage cell line J774.1.	Flavonoids	26-36	tumor necrosis factor	Mus musculus	40-67
12899243-1	2003	An analysis based upon structure-activity relationships (SAR) of the COX-2-inhibiting properties of flavonoids, a group of potential cancer chemopreventative agents, reveals that there is a dual structural basis for these activities.	Flavonoids	100-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
12431781-0	2002	The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells.	Flavonoids	4-13	interferon gamma	Homo sapiens	51-66
12431781-0	2002	The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells.	Flavonoids	4-13	interleukin 4	Homo sapiens	77-80
12357401-0	2002	Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
12426093-4	2002	Oral treatment with flavonoid fraction of khat was found to enhance the activities of GST and catalase but showed no effect on SOD while the level of glucose was decreased and uric acid increased.	Flavonoids	20-29	catalase	Rattus norvegicus	94-102
12150856-0	2002	Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.	Flavonoids	27-37	tumor necrosis factor	Rattus norvegicus	87-96
12150856-0	2002	Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.	Flavonoids	27-37	interleukin 4	Rattus norvegicus	101-105
12027807-0	2002	Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.	Flavonoids	34-43	topoisomerase (DNA) I	Mus musculus	64-83
12210557-0	2002	Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.	Flavonoids	36-46	ATP binding cassette subfamily B member 1	Homo sapiens	89-103
12210557-4	2002	We have been developing flavonoid derivatives as a new class of promising modulators using a new in vitro rational-screening assay based on measurements of the binding-affinity toward the C-terminal nucleotide-binding domain (NBD2) of P-gp.	Flavonoids	24-33	ATP binding cassette subfamily B member 1	Homo sapiens	235-239
12553424-5	2002	Analysis of TTR crystal complexes with several classes of competitors (hormone metabolites, flavonoids, fluorescent probes, analgesics and cardiac agents) revealed multiple modes of binding with both forward and reverse ligand binding orientations.	Flavonoids	92-102	transthyretin	Homo sapiens	12-15
12437593-4	2002	Here we show that PKR activation and eIF2alpha phosphorylation play a significant role in apoptosis of neuroblastoma cells and primary neuronal cultures induced by the beta-amyloid (Abeta) peptides, the calcium ionophore A23187 and flavonoids.	Flavonoids	232-242	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	18-21
12437593-4	2002	Here we show that PKR activation and eIF2alpha phosphorylation play a significant role in apoptosis of neuroblastoma cells and primary neuronal cultures induced by the beta-amyloid (Abeta) peptides, the calcium ionophore A23187 and flavonoids.	Flavonoids	232-242	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	37-46
12437593-4	2002	Here we show that PKR activation and eIF2alpha phosphorylation play a significant role in apoptosis of neuroblastoma cells and primary neuronal cultures induced by the beta-amyloid (Abeta) peptides, the calcium ionophore A23187 and flavonoids.	Flavonoids	232-242	amyloid beta (A4) precursor protein	Mus musculus	168-188
12512693-5	2002	In our work we tried to identify inhibitors of NOS-2 induction within the group of flavonoids, known stimulators of NOS-3 with putative antiatherogenic effects.	Flavonoids	83-93	nitric oxide synthase 2, inducible	Mus musculus	47-52
12512693-5	2002	In our work we tried to identify inhibitors of NOS-2 induction within the group of flavonoids, known stimulators of NOS-3 with putative antiatherogenic effects.	Flavonoids	83-93	nitric oxide synthase 3, endothelial cell	Mus musculus	116-121
12512693-6	2002	Representatives of four main groups of flavonoids: flavonols (kaempferol, quercetin, rutin), flavones (apigenin, primuletin), flavanols (catechine) and flavanones (hesperetin, hesperidin, naringenin) were tried on NOS-2 induction and activity in the in vitro model of LPS-treated macrophages (cell line J774.2).	Flavonoids	39-49	nitric oxide synthase 2, inducible	Mus musculus	214-219
12512693-9	2002	We conclude that some of flavonoids are potent inhibitors of NOS-2 induction.	Flavonoids	25-35	nitric oxide synthase 2, inducible	Mus musculus	61-66
12150856-0	2002	Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.	Flavonoids	27-37	RB transcriptional corepressor like 2	Rattus norvegicus	122-127
12150856-1	2002	To clarify the structure-activity relationships of flavonoids for antiallergic activity, the inhibitory effects of various flavonoids on the release of beta-hexosaminidase, as a marker of degranulation of RBL-2H3 cells, were examined.	Flavonoids	123-133	O-GlcNAcase	Rattus norvegicus	152-171
12150856-4	2002	In addition, several flavonoids, that is apigenin, luteolin, diosmetin, fisetin, and quercetin, inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production from RBL-2H3 cells, both of which participate in the late phase of type I allergic reactions.	Flavonoids	21-31	tumor necrosis factor	Rattus norvegicus	131-140
12150856-4	2002	In addition, several flavonoids, that is apigenin, luteolin, diosmetin, fisetin, and quercetin, inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production from RBL-2H3 cells, both of which participate in the late phase of type I allergic reactions.	Flavonoids	21-31	interleukin 4	Rattus norvegicus	145-149
12656486-0	2002	Influence of flavonoids and vitamins on the MMP- and TIMP-expression of human dermal fibroblasts after UVA irradiation.	Flavonoids	13-23	TIMP metallopeptidase inhibitor 1	Homo sapiens	53-57
12656486-4	2002	The influence of vitamin C, vitamin E and the flavonoids AGR (alpha-glucosylrutin) and 8-prenylnaringenine on the MMP and TIMP expression was investigated.	Flavonoids	46-56	TIMP metallopeptidase inhibitor 1	Homo sapiens	122-126
12206678-0	2002	Repair of amino acid radicals of apolipoprotein B100 of low-density lipoproteins by flavonoids.	Flavonoids	84-94	apolipoprotein B	Homo sapiens	33-52
12235187-1	2002	The grapefruit flavonoid, naringenin, is hypocholesterolemic in vivo, and inhibits basal apolipoprotein B (apoB) secretion and the expression and activities of both ACAT and microsomal triglyceride transfer protein (MTP) in human hepatoma cells (HepG2).	Flavonoids	15-24	apolipoprotein B	Homo sapiens	107-111
12235187-1	2002	The grapefruit flavonoid, naringenin, is hypocholesterolemic in vivo, and inhibits basal apolipoprotein B (apoB) secretion and the expression and activities of both ACAT and microsomal triglyceride transfer protein (MTP) in human hepatoma cells (HepG2).	Flavonoids	15-24	acetyl-CoA acetyltransferase 1	Homo sapiens	165-169
12235187-1	2002	The grapefruit flavonoid, naringenin, is hypocholesterolemic in vivo, and inhibits basal apolipoprotein B (apoB) secretion and the expression and activities of both ACAT and microsomal triglyceride transfer protein (MTP) in human hepatoma cells (HepG2).	Flavonoids	15-24	microsomal triglyceride transfer protein	Homo sapiens	216-219
12349896-3	2002	This flavonoid upregulates PPAR gamma, a transcription factor involved in repressing many cytokine-induced gene expressions.	Flavonoids	5-14	peroxisome proliferator activated receptor gamma	Homo sapiens	27-37
12226490-1	2002	The expression of CHALCONE SYNTHASE (CHS) expression is an important control step in the biosynthesis of flavonoids, which are major photoprotectants in plants.	Flavonoids	105-115	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	18-35
12226490-1	2002	The expression of CHALCONE SYNTHASE (CHS) expression is an important control step in the biosynthesis of flavonoids, which are major photoprotectants in plants.	Flavonoids	105-115	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	37-40
12110385-0	2002	Study of flavonoids/beta-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation.	Flavonoids	9-19	desmocollin 3	Homo sapiens	74-77
12097654-0	2002	Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase.	Flavonoids	0-10	arachidonate 5-lipoxygenase	Homo sapiens	46-60
12135493-7	2002	Site-directed mutagenesis was carried out on the FAE1 KCS to assess if this condensing enzyme was mechanistically related to the well characterized soluble condensing enzymes of fatty acid and flavonoid syntheses.	Flavonoids	193-202	3-ketoacyl-CoA synthase 18	Arabidopsis thaliana	49-53
12097658-0	2002	Flavonoid phytochemicals regulate activator protein-1 signal transduction pathways in endometrial and kidney stable cell lines.	Flavonoids	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-53
12110373-9	2002	Such a delocalization of Cx43 proteins was not observed when TPA was coincubated with the flavonoids, (-)-epicatechin or genistein.	Flavonoids	90-100	gap junction protein, alpha 1	Rattus norvegicus	25-29
12216835-0	2002	Intestinal apolipoprotein B secretion is inhibited by the flavonoid quercetin: potential role of microsomal triglyceride transfer protein and diacylglycerol acyltransferase.	Flavonoids	58-67	apolipoprotein B	Homo sapiens	11-27
12216835-1	2002	Recent studies have yielded evidence that plant flavonoids reduce hepatic lipid and apolipoprotein B (apoB) secretion.	Flavonoids	48-58	apolipoprotein B	Homo sapiens	84-100
12216835-1	2002	Recent studies have yielded evidence that plant flavonoids reduce hepatic lipid and apolipoprotein B (apoB) secretion.	Flavonoids	48-58	apolipoprotein B	Homo sapiens	102-106
12216835-2	2002	However, the possible role of flavonoids in regulating lipid and apoB secretion by the intestine has not been studied.	Flavonoids	30-40	apolipoprotein B	Homo sapiens	65-69
12082016-10	2002	Flavonoids are known to have DNA topoisomerase activity, a Tp53-inducing activity that is confirmed in the assay.	Flavonoids	0-10	tumor protein p53	Homo sapiens	59-63
12044887-3	2002	Among the flavonoids tested, taxifolin was the most potent in inhibiting interferon gamma (IFN gamma)-induced ICAM-1 protein as well as mRNA expression in human keratinocytes.	Flavonoids	10-20	intercellular adhesion molecule 1	Homo sapiens	110-116
12044887-0	2002	Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action.	Flavonoids	0-10	interferon gamma	Homo sapiens	35-44
12044887-0	2002	Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action.	Flavonoids	0-10	intercellular adhesion molecule 1	Homo sapiens	53-59
12044887-1	2002	The effect of plant flavonoids on intercellular adhesion molecule-1 (ICAM-1) expression in human keratinocyte was investigated.	Flavonoids	20-30	intercellular adhesion molecule 1	Homo sapiens	34-67
12044887-1	2002	The effect of plant flavonoids on intercellular adhesion molecule-1 (ICAM-1) expression in human keratinocyte was investigated.	Flavonoids	20-30	intercellular adhesion molecule 1	Homo sapiens	69-75
12044887-3	2002	Among the flavonoids tested, taxifolin was the most potent in inhibiting interferon gamma (IFN gamma)-induced ICAM-1 protein as well as mRNA expression in human keratinocytes.	Flavonoids	10-20	interferon gamma	Homo sapiens	73-100
12135106-1	2002	Previously, several prenylated flavonoids having a C-8 lavandulyl moiety were found to inhibit cyclooxygenase-1 (COX-1) as well as 5-lipoxygenase (5-LOX), and sophoraflavanone G was the most potent inhibitor against these eicosanoid generating enzymes among 19 prenylated flavonoids tested.	Flavonoids	31-41	prostaglandin-endoperoxide synthase 1	Mus musculus	95-111
12135106-1	2002	Previously, several prenylated flavonoids having a C-8 lavandulyl moiety were found to inhibit cyclooxygenase-1 (COX-1) as well as 5-lipoxygenase (5-LOX), and sophoraflavanone G was the most potent inhibitor against these eicosanoid generating enzymes among 19 prenylated flavonoids tested.	Flavonoids	31-41	prostaglandin-endoperoxide synthase 1	Mus musculus	113-118
12135106-1	2002	Previously, several prenylated flavonoids having a C-8 lavandulyl moiety were found to inhibit cyclooxygenase-1 (COX-1) as well as 5-lipoxygenase (5-LOX), and sophoraflavanone G was the most potent inhibitor against these eicosanoid generating enzymes among 19 prenylated flavonoids tested.	Flavonoids	31-41	arachidonate 5-lipoxygenase	Mus musculus	131-145
12135106-1	2002	Previously, several prenylated flavonoids having a C-8 lavandulyl moiety were found to inhibit cyclooxygenase-1 (COX-1) as well as 5-lipoxygenase (5-LOX), and sophoraflavanone G was the most potent inhibitor against these eicosanoid generating enzymes among 19 prenylated flavonoids tested.	Flavonoids	31-41	arachidonate 5-lipoxygenase	Mus musculus	147-152
12135106-4	2002	Other prenylated flavonoids including kuraridin and sanggenon D also down-regulated COX-2 induction at 10-25 uM, while kurarinone and echinoisoflavanone did not.	Flavonoids	17-27	cytochrome c oxidase II, mitochondrial	Mus musculus	84-89
12045333-0	2002	Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity.	Flavonoids	27-37	aldo-keto reductase family 1 member B1	Rattus norvegicus	64-80
12045333-4	2002	In order to clarify the structural requirements of flavonoids for aldose reductase inhibitory activity, various flavonoids and related compounds were examined.	Flavonoids	51-61	aldo-keto reductase family 1 member B1	Rattus norvegicus	66-82
12072474-2	2002	Here, we investigated the effect of Mutator and Spm insertions on the expression of the flavonoid biosynthetic gene a1, independently regulated by the transcription factors C1 and P.	Flavonoids	88-97	anthocyanin regulatory C1 protein	Zea mays	173-181
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Flavonoids	41-53	angiotensinogen	Rattus norvegicus	90-104
12072354-0	2002	Flavonoids exert diverse inhibitory effects on the activation of NF-kappaB.	Flavonoids	0-10	nuclear factor kappa B subunit 1	Homo sapiens	65-74
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Flavonoids	41-53	angiotensinogen	Rattus norvegicus	106-112
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Flavonoids	41-53	mitogen-activated protein kinase 8	Rattus norvegicus	195-218
12074989-4	2002	Consumption of wine flavonoids was shown to preserve paraoxonase activity by reducing the oxidative stress in apolipoprotein E-deficient mice, thereby contributing to paraoxonase hydrolytic activity on lipid peroxides in oxidized lipoproteins and atherosclerotic lesions.	Flavonoids	20-30	apolipoprotein E	Mus musculus	110-126
11834736-0	2002	Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose.	Flavonoids	0-9	solute carrier family 23 member 1	Rattus norvegicus	24-64
11834736-0	2002	Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose.	Flavonoids	0-9	solute carrier family 23 member 1	Rattus norvegicus	66-71
11834736-0	2002	Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose.	Flavonoids	0-9	solute carrier family 2 member 2	Rattus norvegicus	77-106
11834736-0	2002	Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose.	Flavonoids	0-9	solute carrier family 2 member 2	Rattus norvegicus	108-113
11834736-4	2002	We investigated the effects of selected flavonoids on the intestinal vitamin C transporter SVCT1(h) by transfecting and overexpressing SVCT1(h) in Chinese hamster ovary cells.	Flavonoids	40-50	solute carrier family 23 member 1	Rattus norvegicus	91-96
11950788-13	2002	Together, these results strongly suggest that the flavonoid induction of UGT1A1 is through a novel nonaryl hydrocarbon receptor-mediated mechanism.	Flavonoids	50-59	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	73-79
12168845-4	2002	Cell treatment with the flavonoids markedly diminished the extent of cellular protein phosphorylation, by effectively modulating protein tyrosine kinase (PTK) activities, including that of EGFR.	Flavonoids	24-34	epidermal growth factor receptor	Homo sapiens	189-193
12168845-14	2002	The flavonoid-evoked attenuation of the phosphorylation of EFGR and of other proteins appeared to be transient, since removal of the flavonoid from the cell growth medium after 24 hours of incubation followed by exposure to 10 nm EGF, restored protein phosphorylation and cellular proliferation.	Flavonoids	4-13	epidermal growth factor	Homo sapiens	230-233
12168845-18	2002	The antiproliferative effect of flavonoids might result, at least in part, from the modulation of the EGF-mediated signaling pathway.	Flavonoids	32-42	epidermal growth factor	Homo sapiens	102-105
12018987-2	2002	In the present study, the regioselectivity of phase II biotransformation of the model flavonoids luteolin and quercetin by UDP-glucuronosyltransferases was investigated.	Flavonoids	86-96	beta-1,3-glucuronyltransferase 2	Homo sapiens	123-151
12018987-6	2002	The results obtained reveal that regioselectivity is dependent on the model flavonoid of interest, glucuronidation of luteolin and quercetin not following the same pattern, depending on the isoenzyme of UDP-glucuronosyltransferases (UGT) involved.	Flavonoids	76-85	beta-1,3-glucuronyltransferase 2	Homo sapiens	203-231
12018987-6	2002	The results obtained reveal that regioselectivity is dependent on the model flavonoid of interest, glucuronidation of luteolin and quercetin not following the same pattern, depending on the isoenzyme of UDP-glucuronosyltransferases (UGT) involved.	Flavonoids	76-85	beta-1,3-glucuronyltransferase 2	Homo sapiens	233-236
12018987-7	2002	Human UGT1A1, UGT1A8, and UGT1A9 were shown to be especially active in conjugation of both flavonoids, whereas UGT1A4 and UGT1A10 and the isoenzymes from the UGTB family, UGT2B7 and UGT2B15, were less efficient.	Flavonoids	91-101	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-12
12018987-7	2002	Human UGT1A1, UGT1A8, and UGT1A9 were shown to be especially active in conjugation of both flavonoids, whereas UGT1A4 and UGT1A10 and the isoenzymes from the UGTB family, UGT2B7 and UGT2B15, were less efficient.	Flavonoids	91-101	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	14-20
12018987-7	2002	Human UGT1A1, UGT1A8, and UGT1A9 were shown to be especially active in conjugation of both flavonoids, whereas UGT1A4 and UGT1A10 and the isoenzymes from the UGTB family, UGT2B7 and UGT2B15, were less efficient.	Flavonoids	91-101	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	26-32
12018987-7	2002	Human UGT1A1, UGT1A8, and UGT1A9 were shown to be especially active in conjugation of both flavonoids, whereas UGT1A4 and UGT1A10 and the isoenzymes from the UGTB family, UGT2B7 and UGT2B15, were less efficient.	Flavonoids	91-101	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	171-177
12018987-7	2002	Human UGT1A1, UGT1A8, and UGT1A9 were shown to be especially active in conjugation of both flavonoids, whereas UGT1A4 and UGT1A10 and the isoenzymes from the UGTB family, UGT2B7 and UGT2B15, were less efficient.	Flavonoids	91-101	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	182-189
12018987-8	2002	Due to the different regioselectivity and activity displayed by the various UDP-glucuronosyltransferases, regioselectivity and rate of flavonoid conjugation varies with species and organ.	Flavonoids	135-144	beta-1,3-glucuronyltransferase 2	Homo sapiens	76-104
12018987-10	2002	Taking into account the fact that the anti-oxidant action as well as the pro-oxidant toxicity of these catechol-type flavonoids is especially related to their 3",4"-dihydroxyl moiety, it is of interest to note that the human intestine UGT"s appear to be especially effective in conjugating this 3",4" catechol unit.	Flavonoids	117-127	beta-1,3-glucuronyltransferase 2	Homo sapiens	235-238
11950788-0	2002	Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements.	Flavonoids	57-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	47-53
11950788-1	2002	Recent studies in our laboratory in the human hepatic and intestinal cell lines Hep G2 and Caco-2 have demonstrated induction of UGT1A1 by the flavonoid chrysin (5,7-dihydroxyflavone) using catalytic activity assays and Western and Northern blotting.	Flavonoids	143-152	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	129-135
11950788-2	2002	In the present study, we examined which features of the flavonoid structures were associated with induction of UGT1A1 and whether common drug-metabolizing enzyme inducers also produce this induction.	Flavonoids	56-65	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	111-117
11950788-3	2002	We also determined whether flavonoid treatment affected sulfate conjugation and CYP1A1 activity.	Flavonoids	27-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86
11955666-3	2002	Microsomal flavonoid metabolism was potently inhibited by the CYP1A2 inhibitors, fluvoxamine and -naphthoflavone.	Flavonoids	11-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	62-68
11955666-4	2002	Recombinant CYP1A2 was capable of metabolizing all five investigated flavonoids.	Flavonoids	69-79	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-18
11955666-7	2002	The major involvement in flavonoid metabolism of human CYP1A2, which mediates the formation of metabolites with different biochemical properties as compared to the parent compound and furthermore is known to be expressed very differently among individuals, raises the important question of whether individual differences in the CYP enzyme activity might affect the beneficial outcome of dietary flavonoids, rendering some individuals more or less refractory to the health-promoting potential of dietary flavonoids.	Flavonoids	25-34	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	55-61
11955666-7	2002	The major involvement in flavonoid metabolism of human CYP1A2, which mediates the formation of metabolites with different biochemical properties as compared to the parent compound and furthermore is known to be expressed very differently among individuals, raises the important question of whether individual differences in the CYP enzyme activity might affect the beneficial outcome of dietary flavonoids, rendering some individuals more or less refractory to the health-promoting potential of dietary flavonoids.	Flavonoids	395-405	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	55-61
11955666-7	2002	The major involvement in flavonoid metabolism of human CYP1A2, which mediates the formation of metabolites with different biochemical properties as compared to the parent compound and furthermore is known to be expressed very differently among individuals, raises the important question of whether individual differences in the CYP enzyme activity might affect the beneficial outcome of dietary flavonoids, rendering some individuals more or less refractory to the health-promoting potential of dietary flavonoids.	Flavonoids	503-513	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	55-61
12144868-3	2002	In the present study, we demonstrate the potential effects of different flavonoids on cytokines mediated cyclooxygenase-2 and inducible nitric oxide synthase expression and activities in A549 cell line using quercetin, amentoflavone and flavanone.	Flavonoids	72-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-121
11814454-0	2002	Flavonoids can block PSA production by breast and prostate cancer cell lines.	Flavonoids	0-10	kallikrein related peptidase 3	Homo sapiens	21-24
12054621-0	2002	The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells.	Flavonoids	12-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-53
12054621-6	2002	We report here that the dietary flavonoid quercetin also activates HIF-1 alpha in all steps of its activation pathway, in a manner similar to hypoxia.	Flavonoids	32-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-78
12054621-8	2002	Taken together these results strongly indicate that the dietary flavonoid quercetin regulates HIF-1 function at normal oxygen concentrations.	Flavonoids	64-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-99
11999122-6	2002	A large number of compounds are currently known as NF-kappaB modulators and include the isoprenoids, most notably kaurene diterpenoids and members of the sesquiterpene lactones class, several phenolics including curcumin and flavonoids such as silybin.	Flavonoids	225-235	nuclear factor kappa B subunit 1	Homo sapiens	51-60
12028662-10	2002	The results suggest that UGT1A9 is a key UDP-glucuronosyltransferase isoform for the metabolism of flavonoids, and that absorption of intact flavonoid glycosides is possible.	Flavonoids	99-109	UDP glucuronosyltransferase family 1 member A9	Rattus norvegicus	25-31
11809535-0	2002	Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.	Flavonoids	32-41	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
11874895-2	2002	We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors.	Flavonoids	24-33	negative elongation factor complex member C/D	Homo sapiens	196-199
11874895-2	2002	We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors.	Flavonoids	24-33	interferon gamma	Homo sapiens	217-244
12429923-0	2002	The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.	Flavonoids	22-31	RB transcriptional corepressor like 1	Homo sapiens	75-79
12429923-0	2002	The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.	Flavonoids	22-31	RB transcriptional corepressor like 2	Homo sapiens	84-87
12429923-0	2002	The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.	Flavonoids	22-31	RB transcriptional corepressor like 2	Homo sapiens	88-92
11814454-7	2002	METHODS: The ability of 72 flavonoids and related compounds to inhibit PSA production in a breast cancer cell line, BT-474, and a prostate cancer cell line (PC-3), transfected with the human androgen receptor cDNA, PC-3(AR)(2) was examined.	Flavonoids	27-37	kallikrein related peptidase 3	Homo sapiens	71-74
11814454-7	2002	METHODS: The ability of 72 flavonoids and related compounds to inhibit PSA production in a breast cancer cell line, BT-474, and a prostate cancer cell line (PC-3), transfected with the human androgen receptor cDNA, PC-3(AR)(2) was examined.	Flavonoids	27-37	androgen receptor	Homo sapiens	191-208
11814454-8	2002	RESULTS: Twenty-two of the 72 flavonoids tested were found to significantly block PSA production by the BT-474 cell line at the highest tested concentration (10(-5) mol/l), with 17 of these compounds inhibiting production of PSA in the PC-3(AR)(2) cells as well.	Flavonoids	30-40	kallikrein related peptidase 3	Homo sapiens	82-85
11814454-8	2002	RESULTS: Twenty-two of the 72 flavonoids tested were found to significantly block PSA production by the BT-474 cell line at the highest tested concentration (10(-5) mol/l), with 17 of these compounds inhibiting production of PSA in the PC-3(AR)(2) cells as well.	Flavonoids	30-40	kallikrein related peptidase 3	Homo sapiens	225-228
11936218-5	2002	In contrast, all flavonoids tested inhibited hepatic caffeine N"-demethylation (CYP1A2) with IC50 values ranging from 0.7 to 51.3 microM.	Flavonoids	17-27	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
11855907-2	2002	Recent studies show that this bioflavonoid binds to and activates gene transcription via the estrogen receptor (ER) subtypes ERalpha and ERbeta.	Flavonoids	30-42	estrogen receptor 2	Rattus norvegicus	137-143
11948020-6	2002	The flavonoids 6-hydroxyflavone, daidzein, genistein, biochanin A and formononetin strongly and significantly inhibited microsomal 3beta-HSD II activity at concentrations from 1 to 25 microM, and I(50) values were estimated to be 1.3, 2, 1, 0.5 and 2.7 microM, respectively.	Flavonoids	4-14	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Homo sapiens	131-143
11936218-7	2002	These results suggest that flavonoids tested are inhibitors of hepatic CYP1A2 and that the extracts of Scutellariae radix, widely used as a hepatoprotective agent, may protect the liver through the prevention of CYPIA2-induced metabolic activation of protoxicants.	Flavonoids	27-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-77
11936218-0	2002	Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes.	Flavonoids	11-21	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	58-74
11835313-8	2002	These inhibitory effects were partially reversed by quercetin, a bioflavonoid which prevents HSF1 binding to DNA and thus attenuates the HSR.	Flavonoids	65-77	heat shock transcription factor 1	Rattus norvegicus	93-97
11936218-1	2002	A series of flavonoids isolated from Scutellariae radix were evaluated for their effects on cytochrome P-450 (CYP) activities in human liver microsomes.	Flavonoids	12-22	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-108
11936218-1	2002	A series of flavonoids isolated from Scutellariae radix were evaluated for their effects on cytochrome P-450 (CYP) activities in human liver microsomes.	Flavonoids	12-22	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	110-113
11853467-3	2002	Y(n) type fragment ions, created after glycosidic bond cleavage with oxygen retention on sugar at the reducing end for permethylated compounds, were observed in the normal and linked-scan mass spectra recorded for alpha(1-2) bonded conjugates of flavonoid di- and tri-glycosides.	Flavonoids	246-255	adrenoceptor alpha 1D	Homo sapiens	214-223
11792676-1	2002	There is very limited information on cytochrome P450 (P450)-mediated oxidative metabolism of dietary flavonoids in humans.	Flavonoids	101-111	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	48-52
11790449-6	2002	These results suggest that flavonoids are potent regulators of cyclin B and p21 for cell cycle progression, which may play some roles in prevention of carcinogenesis.	Flavonoids	27-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-79
11792676-1	2002	There is very limited information on cytochrome P450 (P450)-mediated oxidative metabolism of dietary flavonoids in humans.	Flavonoids	101-111	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	54-58
11870780-0	2002	Inhibition of heat-induced phosphorylation of stathmin by the bioflavonoid quercetin.	Flavonoids	62-74	stathmin 1	Homo sapiens	46-54
11823753-10	2002	Other furanocoumarins and bioflavonoids also reduced rat oatp3 activity.	Flavonoids	26-39	solute carrier organic anion transporter family, member 1A5	Rattus norvegicus	57-62
12083459-2	2002	We have tested the effect of a variety of dietary phytoestrogens, especially flavonoids, on the activity of human 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD 5), a key enzyme in the metabolism of estrogens and androgens.	Flavonoids	77-87	RNA, U1 small nuclear 4	Homo sapiens	114-170
11803026-9	2002	On the other hand, inhibition of CYPs involved in carcinogen activation and scavenging reactive species formed from carcinogens by CYP-mediated reactions can be beneficial properties of various flavonoids.	Flavonoids	194-204	peptidylprolyl isomerase G	Homo sapiens	33-36
12112014-0	2002	Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells.	Flavonoids	54-64	integrin-binding sialoprotein	Rattus norvegicus	14-31
12112014-3	2002	The present study investigates regulation of BSP transcription in rat osteosarcoma ROS 17/2.8 cells by flavonoids: genistein (an inhibitor of protein tyrosine kinases), daidzein (an inactive compound of genistein), flavone, and flavanone.	Flavonoids	103-113	integrin-binding sialoprotein	Rattus norvegicus	45-48
12112014-9	2002	These data suggest that the inverted CCAAT box is required for flavonoid-induced BSP expression and that the stimulatory action is dependent on the flavone structure and does not involve an inhibitory action on protein tyrosine kinase.	Flavonoids	63-72	integrin-binding sialoprotein	Rattus norvegicus	81-84
11752233-0	2002	Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.	Flavonoids	0-10	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-86
11807956-0	2002	A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin.	Flavonoids	153-162	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	2-10
11807956-0	2002	A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin.	Flavonoids	153-162	alpha- and gamma-adaptin binding protein	Mus musculus	90-93
11807956-0	2002	A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin.	Flavonoids	153-162	cyclin-dependent kinase 1	Mus musculus	94-98
11744299-4	2002	LCAT showed elevated levels in rats fed flavonoids from E. officinalis and M. indica.	Flavonoids	40-50	lecithin cholesterol acyltransferase	Rattus norvegicus	0-4
11796114-2	2002	Anthocyanidin synthase (ANS), a 2-oxoglutarate iron-dependent oxygenase, catalyzes the penultimate step in the biosynthesis of the anthocyanin class of flavonoids.	Flavonoids	152-162	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	0-22
11752233-0	2002	Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.	Flavonoids	0-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	91-97
11705451-2	2001	In this study, the effects of 19 naturally occurring prenylated flavonoids, isolated from medicinal plants, on cyclooxygenase (COX)-1 and COX-2 and on 5-lipoxygenase (5-LOX) and 12-LOX were investigated using [14C]arachidonic acid as a substrate.	Flavonoids	64-74	cytochrome c oxidase I, mitochondrial	Mus musculus	111-133
11717168-10	2001	These results suggest that during inflammation beta-glucuronidase is released from stimulated neutrophils or certain injured cells and then deglucuronidation of flavonoids occurs.	Flavonoids	161-171	glucuronidase, beta	Rattus norvegicus	47-65
11705451-2	2001	In this study, the effects of 19 naturally occurring prenylated flavonoids, isolated from medicinal plants, on cyclooxygenase (COX)-1 and COX-2 and on 5-lipoxygenase (5-LOX) and 12-LOX were investigated using [14C]arachidonic acid as a substrate.	Flavonoids	64-74	cytochrome c oxidase II, mitochondrial	Mus musculus	138-143
11705451-2	2001	In this study, the effects of 19 naturally occurring prenylated flavonoids, isolated from medicinal plants, on cyclooxygenase (COX)-1 and COX-2 and on 5-lipoxygenase (5-LOX) and 12-LOX were investigated using [14C]arachidonic acid as a substrate.	Flavonoids	64-74	arachidonate 5-lipoxygenase	Mus musculus	151-165
11705451-2	2001	In this study, the effects of 19 naturally occurring prenylated flavonoids, isolated from medicinal plants, on cyclooxygenase (COX)-1 and COX-2 and on 5-lipoxygenase (5-LOX) and 12-LOX were investigated using [14C]arachidonic acid as a substrate.	Flavonoids	64-74	arachidonate 15-lipoxygenase	Mus musculus	178-184
11705451-4	2001	Among the 19 prenylated flavonoids, morusin, kuwanon C, sanggenon B, sanggenon D and kazinol B inhibited COX-2 activity (ic(50) = 73-100 microM), but the potencies were far less than that of NS-398 (ic(50) = 2.9 microM).	Flavonoids	24-34	cytochrome c oxidase II, mitochondrial	Mus musculus	105-110
11705451-5	2001	In contrast, many prenylated flavonoids, such as kuraridin, kuwanon C and sophoraisoflavanone A, inhibited COX-1 activity.	Flavonoids	29-39	cytochrome c oxidase I, mitochondrial	Mus musculus	107-112
11705451-6	2001	Of the COX-1 inhibiting prenylated flavonoids, kuraridin, kurarinone, and sophoraflavanone G, all having a C-8 lavandulyl moiety, showed potent activity (ic(50) = 0.1 to 1 microM) comparable to that of indomethacin (ic(50) = 0.7 microM).	Flavonoids	35-45	cytochrome c oxidase I, mitochondrial	Mus musculus	7-12
11561098-0	2001	Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells.	Flavonoids	0-10	solute carrier family 15 member 1	Homo sapiens	95-100
11561098-1	2001	We have tested 33 flavonoids, occurring ubiquitously in foods of plant origin, for their ability to alter the transport of the beta-lactam antibiotic cefixime via the H+-coupled intestinal peptide transporter PEPT1 in the human intestinal epithelial cell line Caco-2.	Flavonoids	18-28	solute carrier family 15 member 1	Homo sapiens	209-214
11561098-9	2001	In conclusion, our studies show that flavonoids with EGF-receptor tyrosine kinase inhibitory activities enhance the intestinal absorption of the beta-lactam antibiotic cefixime in Caco-2 cells by activation of apical Na+/H+-exchange and a concomitant increase of the driving force for PEPT1.	Flavonoids	37-47	solute carrier family 15 member 1	Homo sapiens	285-290
11562426-4	2001	Thus, we hypothesized that bioflavonoids may affect Ang II-induced MAP kinase activation in cultured rat aortic smooth muscle cells (RASMC).	Flavonoids	27-40	angiotensinogen	Rattus norvegicus	52-58
11838316-0	2001	Tartary buckwheat flavonoid activates caspase 3 and induces HL-60 cell apoptosis.	Flavonoids	18-27	caspase 3	Homo sapiens	38-47
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Flavonoids	100-112	angiotensinogen	Rattus norvegicus	0-6
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Flavonoids	100-112	mitogen-activated protein kinase 8	Rattus norvegicus	15-18
11697467-14	2001	CONCLUSIONS: These results suggest an important role for the multispecific organic anion transporter MRP2 in the bioavailability of EC and possibly other tea flavonoids.	Flavonoids	158-168	ATP binding cassette subfamily C member 2	Homo sapiens	101-105
12240335-0	2001	Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis.	Flavonoids	37-46	complement C3	Homo sapiens	26-29
12240335-1	2001	Evidence is presented for initial oxidation at the C-3 position of the flavonoid C-ring and for two bifurcating steps during catalysis by anthocyanidin synthase.	Flavonoids	71-80	complement C3	Homo sapiens	51-54
11550075-10	2001	Nonsteroidal aromatase inhibitors can be divided into three classes: aminoglutethimide-like molecules, imidazole/triazole derivatives, and flavonoid analogs.	Flavonoids	139-148	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	13-22
11535118-0	2001	Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.	Flavonoids	0-10	mitogen-activated protein kinase 8	Homo sapiens	93-116
11535118-0	2001	Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.	Flavonoids	0-10	mitogen-activated protein kinase 8	Homo sapiens	118-121
11535118-0	2001	Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.	Flavonoids	0-10	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
11535118-0	2001	Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.	Flavonoids	0-10	caspase 3	Homo sapiens	134-143
11535118-7	2001	oxLDL caused a sustained activation of JNK that resulted in the phosphorylation of the transcription factor c-Jun, which was abolished in neurons pre-treated with flavonoids.	Flavonoids	163-173	mitogen-activated protein kinase 8	Homo sapiens	39-42
11535118-7	2001	oxLDL caused a sustained activation of JNK that resulted in the phosphorylation of the transcription factor c-Jun, which was abolished in neurons pre-treated with flavonoids.	Flavonoids	163-173	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-113
11553037-5	2001	Epicatechin, a member of a group of polyphenolic compounds collectively known as "catechins" that are present in tea and belong to the flavonoid family, has been reported to possess insulin-like activity.	Flavonoids	135-144	insulin	Homo sapiens	182-189
11579688-8	2001	Because the signal-regulated synthesis of some secondary metabolites by the lipid signalling pathway has been already shown (induction of the gene expression coding the biosynthetic enzymes of flavonoids and terpenoids), the area of PLD study is perspective.	Flavonoids	193-203	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	233-236
11520867-10	2001	In transgenic potato plants, increased PEPC activities resulted in a decline in UV protectants (flavonoids) in single cppc or stppc transformants, but not in double transformants (cppc/fpMe1).	Flavonoids	96-106	phosphoenolpyruvate carboxylase	Solanum tuberosum	39-43
11520867-11	2001	PEP provision to the shikimate pathway inside the plastids, from which flavonoids derive, might be restricted only in single PEPC overexpressors.	Flavonoids	71-81	phosphoenolpyruvate carboxylase	Solanum tuberosum	125-129
11737987-0	2001	Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds.	Flavonoids	50-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-26
11595503-2	2001	Several flavonoids such as 7-hydroxyflavone and chrysin (5,7-dihydroxyflavone) were shown to inhibit the formation of 3H-17beta-estradiol from 3H-androstenedione (IC(50)&lt;1.0 microM) in human choriocarcinoma JEG-3 cells and in human embryonic kidney cells HEK 293 transfected with human aromatase gene (Arom+HEK 293).	Flavonoids	8-18	PARP1 binding protein	Homo sapiens	305-309
11737987-1	2001	PURPOSE: To evaluate the inhibition of CYP3A4 activity in human liver microsomes by flavonoids, furanocoumarins and related compounds and investigate possibly more important and potential inhibitors of CYP3A4 in grapefruit juice.	Flavonoids	84-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-45
11737987-2	2001	METHODS: The effects of various flavonoids and furanocoumarin derivatives on CYP3A4 activity in two human liver microsomal samples was determined using quinine as a substrate.	Flavonoids	32-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
11440974-5	2001	TNF-alpha induction of fibronectin synthesis was abrogated by the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMMA) (P&lt;0.05) or the flavonoid-containing enzyme inhibitor diphenyleneiodonium (DPI) (P&lt;0.05) and reproduced with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) (P&lt;0.05).	Flavonoids	135-144	tumor necrosis factor	Homo sapiens	0-9
11513863-5	2001	Furthermore, pure recombinant human beta-glucuronidase hydrolysed various flavonoid glucuronides, with a 20-fold variation in catalytic efficiency (k(cat)/K(m)=1.3x10(3) M(-1) s(-1) for equol-7-O-glucuronide and 26x10(3) M(-1) s(-1) for kaempferol-3-O-glucuronide).	Flavonoids	74-83	glucuronidase beta	Homo sapiens	36-54
11478778-6	2001	M-form (SULT1A3) PST showed high activity with the flavonoids but not with the isoflavonoids.	Flavonoids	51-61	sulfotransferase family 1A member 3	Homo sapiens	8-15
11478778-6	2001	M-form (SULT1A3) PST showed high activity with the flavonoids but not with the isoflavonoids.	Flavonoids	51-61	sulfotransferase family 1A member 1	Homo sapiens	17-20
11507741-12	2001	These effects suggest that this flavonoid might cause inhibition of NEP and/or ACE.	Flavonoids	32-41	membrane metallo-endopeptidase	Rattus norvegicus	68-71
11507741-12	2001	These effects suggest that this flavonoid might cause inhibition of NEP and/or ACE.	Flavonoids	32-41	angiotensin I converting enzyme	Rattus norvegicus	79-82
11456154-2	2001	methanogenic consortia were enriched which converted various flavonoids at initial concentration of 0.5 3.0mM during stationary incubation at 37 degrees C in serum bottles with specific rates ranging from 0.025 to 0.073 micromol min(-1) (mg protein)(-1).	Flavonoids	61-71	CD59 molecule (CD59 blood group)	Homo sapiens	229-235
11549766-2	2001	At least three TRANSPARENT TESTA (TT) genes, TT2, TT8, and TTG1, are necessary for the normal expression of several flavonoid structural genes in immature seed, such as DIHYDROFLAVONOL-4-REDUCTASE and BANYULS (BAN).	Flavonoids	116-125	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	45-48
11549766-2	2001	At least three TRANSPARENT TESTA (TT) genes, TT2, TT8, and TTG1, are necessary for the normal expression of several flavonoid structural genes in immature seed, such as DIHYDROFLAVONOL-4-REDUCTASE and BANYULS (BAN).	Flavonoids	116-125	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	50-53
11549766-2	2001	At least three TRANSPARENT TESTA (TT) genes, TT2, TT8, and TTG1, are necessary for the normal expression of several flavonoid structural genes in immature seed, such as DIHYDROFLAVONOL-4-REDUCTASE and BANYULS (BAN).	Flavonoids	116-125	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	59-63
11549766-2	2001	At least three TRANSPARENT TESTA (TT) genes, TT2, TT8, and TTG1, are necessary for the normal expression of several flavonoid structural genes in immature seed, such as DIHYDROFLAVONOL-4-REDUCTASE and BANYULS (BAN).	Flavonoids	116-125	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	201-208
11549766-2	2001	At least three TRANSPARENT TESTA (TT) genes, TT2, TT8, and TTG1, are necessary for the normal expression of several flavonoid structural genes in immature seed, such as DIHYDROFLAVONOL-4-REDUCTASE and BANYULS (BAN).	Flavonoids	116-125	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	201-204
11513863-2	2001	We hypothesise that the potential availability of the aglycone within tissues depends on the substrate specificity of the deconjugating enzyme beta-glucuronidase towards circulating flavonoid glucuronides.	Flavonoids	182-191	glucuronidase beta	Homo sapiens	143-161
11454723-0	2001	The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression.	Flavonoids	78-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-104
11454723-1	2001	We examined the effects of several agents, including dietary flavonoids, on CYP1A1 expression utilizing a recently developed high-throughput screening system for assessing human cytochrome P450 (CYP) induction.	Flavonoids	61-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	76-82
11454723-1	2001	We examined the effects of several agents, including dietary flavonoids, on CYP1A1 expression utilizing a recently developed high-throughput screening system for assessing human cytochrome P450 (CYP) induction.	Flavonoids	61-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	76-79
11454723-3	2001	Of these flavonoids, resveratrol produced the greatest increase in CYP1A1-mediated luciferase activity (10-fold), whereas GTE, apigenin, curcumin, and kaempferol produced 2- to 3-fold increases in activity.	Flavonoids	9-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-73
11454723-6	2001	Cotreatment of cells with TCDD and GTE, naringenin, and apigenin resulted in 58, 77, and 74% reductions, respectively, in TCDD-mediated CYP1A1 induction, indicating that these flavonoids exhibit potential antagonist activity toward the aryl hydrocarbon (Ah) receptor.	Flavonoids	176-186	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	136-142
11454723-6	2001	Cotreatment of cells with TCDD and GTE, naringenin, and apigenin resulted in 58, 77, and 74% reductions, respectively, in TCDD-mediated CYP1A1 induction, indicating that these flavonoids exhibit potential antagonist activity toward the aryl hydrocarbon (Ah) receptor.	Flavonoids	176-186	aryl hydrocarbon receptor	Homo sapiens	236-266
11697193-4	2001	Also, .UH- is reduced by flavonoids, quercetin and rutin in CTAB micelles at rate constants of 6 x 10(6) M-1s-1 and 1 x 10(6) M-1s-1, respectively.	Flavonoids	25-35	tumor associated calcium signal transducer 2	Homo sapiens	105-132
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Flavonoids	19-31	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Flavonoids	19-31	interleukin 6	Homo sapiens	154-157
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Flavonoids	19-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-167
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Flavonoids	19-31	interleukin 6	Homo sapiens	266-269
11440974-5	2001	TNF-alpha induction of fibronectin synthesis was abrogated by the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMMA) (P&lt;0.05) or the flavonoid-containing enzyme inhibitor diphenyleneiodonium (DPI) (P&lt;0.05) and reproduced with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) (P&lt;0.05).	Flavonoids	135-144	fibronectin 1	Homo sapiens	23-34
11476978-4	2001	Flavonoid pretreatment reduced the serum tumor necrosis factor-alpha (TNF-alpha) level in mice injected with D-GalN and LPS, but not in mice injected with a high dose of LPS.	Flavonoids	0-9	tumor necrosis factor	Mus musculus	41-68
11453730-2	2001	In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-glutathione conjugates of catechin and mono- and bi-glutathione conjugates of a catechin dimer.	Flavonoids	118-127	tyrosinase	Rattus norvegicus	170-180
11476978-4	2001	Flavonoid pretreatment reduced the serum tumor necrosis factor-alpha (TNF-alpha) level in mice injected with D-GalN and LPS, but not in mice injected with a high dose of LPS.	Flavonoids	0-9	tumor necrosis factor	Mus musculus	70-79
11476978-4	2001	Flavonoid pretreatment reduced the serum tumor necrosis factor-alpha (TNF-alpha) level in mice injected with D-GalN and LPS, but not in mice injected with a high dose of LPS.	Flavonoids	0-9	galanin and GMAP prepropeptide	Mus musculus	111-115
11476978-5	2001	TNF-alpha-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality.	Flavonoids	97-107	tumor necrosis factor	Mus musculus	0-9
11476978-5	2001	TNF-alpha-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality.	Flavonoids	97-107	galanin and GMAP prepropeptide	Mus musculus	36-40
11476978-5	2001	TNF-alpha-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality.	Flavonoids	97-107	tumor necrosis factor	Mus musculus	164-173
11476978-5	2001	TNF-alpha-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality.	Flavonoids	125-135	tumor necrosis factor	Mus musculus	0-9
11476978-5	2001	TNF-alpha-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality.	Flavonoids	125-135	galanin and GMAP prepropeptide	Mus musculus	36-40
11476978-5	2001	TNF-alpha-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-alpha lethality.	Flavonoids	125-135	tumor necrosis factor	Mus musculus	164-173
11408547-7	2001	Quercetin, a flavonoid compound known to block As(III)-related induction of P-glycoprotein, was also found to prevent up-regulation of MRP2 gene expression in rat hepatocytes exposed to As(III).	Flavonoids	13-22	ATP binding cassette subfamily C member 2	Rattus norvegicus	135-139
11489181-10	2001	Staining of flavonoid endproducts with DPBA was consistent with expression of CHS and CHI in these seedlings.	Flavonoids	12-21	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	86-89
11396955-0	2001	Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.	Flavonoids	34-44	sterol O-acyltransferase 1	Oryctolagus cuniculus	95-99
11396955-0	2001	Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.	Flavonoids	34-44	vascular cell adhesion protein 1	Oryctolagus cuniculus	111-117
11396955-0	2001	Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.	Flavonoids	34-44	C-C motif chemokine 2	Oryctolagus cuniculus	122-127
11396955-7	2001	The expression levels of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1), by semiquantitative RT-PCR analysis of the thoracic aorta, were significantly lower in the flavonoids supplemented groups than in the control group.	Flavonoids	203-213	vascular cell adhesion protein 1	Oryctolagus cuniculus	25-58
11396955-7	2001	The expression levels of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1), by semiquantitative RT-PCR analysis of the thoracic aorta, were significantly lower in the flavonoids supplemented groups than in the control group.	Flavonoids	203-213	C-C motif chemokine 2	Oryctolagus cuniculus	72-102
11396955-7	2001	The expression levels of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1), by semiquantitative RT-PCR analysis of the thoracic aorta, were significantly lower in the flavonoids supplemented groups than in the control group.	Flavonoids	203-213	C-C motif chemokine 2	Oryctolagus cuniculus	104-109
11396955-8	2001	These results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.	Flavonoids	69-79	vascular cell adhesion protein 1	Oryctolagus cuniculus	188-194
11396955-8	2001	These results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.	Flavonoids	69-79	C-C motif chemokine 2	Oryctolagus cuniculus	199-204
11322923-2	2001	Some flavonoids, such as flavone derivatives, have been reported previously to inhibit nitric oxide (NO) production by suppressing inducible nitric oxide synthase (iNOS) expression.	Flavonoids	5-15	nitric oxide synthase 2, inducible	Mus musculus	131-162
11262417-1	2001	The flavonoid genistein and the benzo[c]quinolizinium MPB-07 have been shown to activate the cystic fibrosis transmembrane conductance regulator (CFTR), the protein that is defective in cystic fibrosis.	Flavonoids	4-13	CF transmembrane conductance regulator	Homo sapiens	93-144
11262417-1	2001	The flavonoid genistein and the benzo[c]quinolizinium MPB-07 have been shown to activate the cystic fibrosis transmembrane conductance regulator (CFTR), the protein that is defective in cystic fibrosis.	Flavonoids	4-13	CF transmembrane conductance regulator	Homo sapiens	146-150
11458449-1	2001	We examined the effects of various flavonoids isolated from the roots of Scutellaria baicalensis Georgi on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide (SFLLRNPNDKYEPF, TRAP) in cultured human umbilical vein endothelial cells.	Flavonoids	35-45	coagulation factor II, thrombin	Homo sapiens	147-155
11458449-1	2001	We examined the effects of various flavonoids isolated from the roots of Scutellaria baicalensis Georgi on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide (SFLLRNPNDKYEPF, TRAP) in cultured human umbilical vein endothelial cells.	Flavonoids	35-45	coagulation factor II, thrombin	Homo sapiens	160-168
11401161-3	2001	The MSn spectra obtained allowed us to propose plausible schemes for their fragmentation supported by the analysis of five complementary synthetic flavonoid aglycones.	Flavonoids	147-156	moesin	Homo sapiens	4-7
11409965-2	2001	From seven structurally divergent groups of flavonoids, only flavonols with a free hydroxyl group at the C-3 position of the flavonoid skeleton showed high inhibitory activity to beta-carotene oxidation.	Flavonoids	44-54	complement C3	Homo sapiens	105-108
11409965-2	2001	From seven structurally divergent groups of flavonoids, only flavonols with a free hydroxyl group at the C-3 position of the flavonoid skeleton showed high inhibitory activity to beta-carotene oxidation.	Flavonoids	44-53	complement C3	Homo sapiens	105-108
11322923-2	2001	Some flavonoids, such as flavone derivatives, have been reported previously to inhibit nitric oxide (NO) production by suppressing inducible nitric oxide synthase (iNOS) expression.	Flavonoids	5-15	nitric oxide synthase 2, inducible	Mus musculus	164-168
11322924-0	2001	Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.	Flavonoids	32-42	cyclin dependent kinase 2	Homo sapiens	133-137
11322924-0	2001	Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.	Flavonoids	32-42	cyclin dependent kinase 1	Homo sapiens	142-146
11322924-4	2001	We demonstrate that flavonoids, which induced a cell cycle block in G1, inhibited the activity of CDK2 by 40-60%.	Flavonoids	20-30	cyclin dependent kinase 2	Homo sapiens	98-102
11343698-3	2001	In addition, these three flavonoids strongly enhanced the inhibition of inducible cyclooxygenase and inducible nitric oxide synthase promoter activities in lipopolysaccharide-activated macrophages which contain the PPAR gamma expression plasmids.	Flavonoids	25-35	peroxisome proliferator activated receptor gamma	Mus musculus	215-225
11343698-4	2001	However, these three flavonoids exhibited weak PPAR gamma agonist activities in an in vitro competitive binding assay.	Flavonoids	21-31	peroxisome proliferator activated receptor gamma	Mus musculus	47-57
11343698-5	2001	Limited protease digestion of PPAR gamma suggested these three flavonoids produced a conformational change in PPAR gamma and the conformation differs in the receptor bound to BRL49653 versus these three flavonoids.	Flavonoids	63-73	peroxisome proliferator activated receptor gamma	Mus musculus	30-40
11343698-5	2001	Limited protease digestion of PPAR gamma suggested these three flavonoids produced a conformational change in PPAR gamma and the conformation differs in the receptor bound to BRL49653 versus these three flavonoids.	Flavonoids	63-73	peroxisome proliferator activated receptor gamma	Mus musculus	110-120
11343698-5	2001	Limited protease digestion of PPAR gamma suggested these three flavonoids produced a conformational change in PPAR gamma and the conformation differs in the receptor bound to BRL49653 versus these three flavonoids.	Flavonoids	203-213	peroxisome proliferator activated receptor gamma	Mus musculus	30-40
11343698-5	2001	Limited protease digestion of PPAR gamma suggested these three flavonoids produced a conformational change in PPAR gamma and the conformation differs in the receptor bound to BRL49653 versus these three flavonoids.	Flavonoids	203-213	peroxisome proliferator activated receptor gamma	Mus musculus	110-120
11343698-6	2001	These results suggested that these three flavonoids might act as allosteric effectors and were able to bind to PPAR gamma and activate it, but its binding site might be different from the natural ligand BRL49653.	Flavonoids	41-51	peroxisome proliferator activated receptor gamma	Mus musculus	111-121
11302779-7	2001	Flavonoids, particularly quercetin and its derivatives, are potent inhibitors of aldose reductase.	Flavonoids	0-10	aldo-keto reductase family 1 member B	Homo sapiens	81-97
11352979-0	2001	Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.	Flavonoids	49-59	apolipoprotein B	Homo sapiens	24-28
11352979-0	2001	Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.	Flavonoids	49-59	acetyl-CoA acetyltransferase 2	Homo sapiens	127-132
11352979-0	2001	Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.	Flavonoids	49-59	microsomal triglyceride transfer protein	Homo sapiens	137-140
11352979-3	2001	The ability of these flavonoids to modulate apolipoprotein B (apoB) secretion and cellular cholesterol homeostasis was determined in the human hepatoma cell line, HepG2.	Flavonoids	21-31	apolipoprotein B	Homo sapiens	44-60
11352979-3	2001	The ability of these flavonoids to modulate apolipoprotein B (apoB) secretion and cellular cholesterol homeostasis was determined in the human hepatoma cell line, HepG2.	Flavonoids	21-31	apolipoprotein B	Homo sapiens	62-66
11352979-8	2001	However, in HepG2 cells, ACAT2 mRNA was selectively decreased (- 50%, P &lt; 0.001) by both flavonoids, whereas ACAT1 mRNA was unaffected.	Flavonoids	92-102	acetyl-CoA acetyltransferase 2	Homo sapiens	25-30
11352979-12	2001	Together with an enhanced expression of the LDL receptor, these mechanisms may explain the hypocholesterolemic properties of the citrus flavonoids.	Flavonoids	136-146	low density lipoprotein receptor	Homo sapiens	44-56
11306701-0	2001	Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids.	Flavonoids	118-128	ATP binding cassette subfamily B member 1	Homo sapiens	14-44
11306701-0	2001	Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids.	Flavonoids	118-128	ATP binding cassette subfamily B member 1	Homo sapiens	46-50
11306701-0	2001	Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids.	Flavonoids	118-128	ATP binding cassette subfamily C member 1	Homo sapiens	51-56
11306701-3	2001	Most flavonoids inhibited MRP1-mediated LTC(4) transport in membrane vesicles and inhibition by several flavonoids was enhanced by GSH.	Flavonoids	5-15	ATP binding cassette subfamily B member 1	Homo sapiens	26-30
11306701-7	2001	Several flavonoids, especially naringenin and apigenin, markedly stimulated GSH transport by MRP1, suggesting they may be cotransported with this tripeptide.	Flavonoids	8-18	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
11708139-4	2001	A quantitative structure-activity relationship was obtained to describe the AA of flavonoids: IC50(microM) = 30.36 + 151.50 E1/2 (V) -12.63 log P (r = 0.852), where IC50 represents the concentration for 50% inhibition of LPO, and P represents the octanol/water partition coefficient.	Flavonoids	82-92	small nucleolar RNA, H/ACA box 73A	Homo sapiens	124-132
11370705-0	2001	Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.	Flavonoids	13-23	aldo-keto reductase family 1 member B1	Rattus norvegicus	45-61
11370705-11	2001	Of the 35 4,2"-dihydroxyl and 2",4"-dihydroxyl derivatives of flavonoid synthesized, including chalcone, flavone, flavanone, flavonol and dihydrochalcone, some chalcone derivatives synthesized were found to possess aldose reductase inhibition and antioxidant activities in-vitro as well as inhibition in the accumulation of sorbitol in the tissues in-vivo.	Flavonoids	62-71	aldo-keto reductase family 1 member B1	Rattus norvegicus	215-231
11306701-11	2001	We conclude that dietary flavonoids may modulate the organic anion and GSH transport, ATPase, and/or drug resistance-conferring properties of MRP1.	Flavonoids	25-35	ATP binding cassette subfamily B member 1	Homo sapiens	142-146
11306701-12	2001	However, the activity profile of the flavonoids tested differed from one another, suggesting that at least some of these compounds may interact with different sites on the MRP1 molecule.	Flavonoids	37-47	ATP binding cassette subfamily B member 1	Homo sapiens	172-176
11323156-1	2001	The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to toxic halogenated aromatic toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polynuclear aromatic hydrocarbons, combustion products, and numerous phytochemicals such as flavonoids and indole-3-carbinol (I3C).	Flavonoids	292-302	aryl hydrocarbon receptor	Homo sapiens	4-29
11346885-1	2001	We recently showed the inhibitory effect of a flavonoid antioxidant, silymarin, on erbB1-Shc activation in prostate cancer (PCA) DU145 cells.	Flavonoids	46-55	epidermal growth factor receptor	Homo sapiens	83-88
11346885-1	2001	We recently showed the inhibitory effect of a flavonoid antioxidant, silymarin, on erbB1-Shc activation in prostate cancer (PCA) DU145 cells.	Flavonoids	46-55	SHC adaptor protein 1	Homo sapiens	89-92
11283341-0	2001	The TRANSPARENT TESTA12 gene of Arabidopsis encodes a multidrug secondary transporter-like protein required for flavonoid sequestration in vacuoles of the seed coat endothelium.	Flavonoids	112-121	MATE efflux family protein	Arabidopsis thaliana	16-23
11283341-4	2001	Double mutants with tt12 and other testa pigmentation mutants were constructed, and their phenotypes confirmed that tt12 was affected at the level of the flavonoid biosynthetic pathway.	Flavonoids	154-163	MATE efflux family protein	Arabidopsis thaliana	116-120
11283341-8	2001	The phenotype of the mutant and the nature of the gene suggest that TT12 may control the vacuolar sequestration of flavonoids in the seed coat endothelium.	Flavonoids	115-125	MATE efflux family protein	Arabidopsis thaliana	68-72
11323156-3	2001	TCDD, a "xenodioxin", is a multi-site carcinogen in several species and possibly in humans, whereas natural AhR ligands including I3C and flavonoids tend to protect against cancer.	Flavonoids	138-148	aryl hydrocarbon receptor	Homo sapiens	108-111
11323156-1	2001	The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to toxic halogenated aromatic toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polynuclear aromatic hydrocarbons, combustion products, and numerous phytochemicals such as flavonoids and indole-3-carbinol (I3C).	Flavonoids	292-302	aryl hydrocarbon receptor	Homo sapiens	31-34
11396135-2	2001	Previous studies have shown that natural compounds such as prenyl flavonoids are able to modulate the multidrug resistance phenotype of P-glycoprotein-positive cancer cells.	Flavonoids	66-76	ATP binding cassette subfamily B member 1	Homo sapiens	136-150
11262086-0	2001	C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance.	Flavonoids	20-30	ATP binding cassette subfamily B member 1	Homo sapiens	64-78
11319034-1	2001	The Arabidopsis gene encoding the key flavonoid biosynthesis enzyme chalcone synthase (CHS) is regulated by several environmental and endogenous stimuli.	Flavonoids	38-47	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	68-85
11442279-0	2001	Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation.	Flavonoids	55-64	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-40
11442279-0	2001	Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation.	Flavonoids	55-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	41-47
11442279-2	2001	Recently, we showed that the flavonoid chrysin induced UDP-glucuronosyltransferase (UGT) activity and expression in the human intestinal cell line Caco-2.	Flavonoids	29-38	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	55-82
11442279-2	2001	Recently, we showed that the flavonoid chrysin induced UDP-glucuronosyltransferase (UGT) activity and expression in the human intestinal cell line Caco-2.	Flavonoids	29-38	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	84-87
11442279-10	2001	CONCLUSION: Dietary flavonoid-mediated induction of intestinal UGT1A1 may be important for the glucuronidation and detoxification of colon and other carcinogens as well as for the presystemic metabolism of therapeutic drugs.	Flavonoids	20-29	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	63-69
11301858-5	2001	Four major flavonoids from Scutellaria Root were found to show inhibitory activity on eotaxin production at a concentration of 10 micrograms/ml in the order of baicalein &gt; oroxylin A &gt; baicalin &gt; skullcapflavon II.	Flavonoids	11-21	C-C motif chemokine ligand 11	Homo sapiens	86-93
11319034-1	2001	The Arabidopsis gene encoding the key flavonoid biosynthesis enzyme chalcone synthase (CHS) is regulated by several environmental and endogenous stimuli.	Flavonoids	38-47	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	87-90
11429999-1	2001	A facile and efficient approach for the syntheses of both C-8 and C-6 prenylated flavonoids has been developed that features a highly regioselective prenylation of 2,4,6-trihydroxyacetophenone and regioselective cyclization of prenylated polyhydroxy chalcones.	Flavonoids	81-91	complement C6	Homo sapiens	66-69
11165023-2	2001	In our study we tested the influence of environmental hormones, such as phytoestrogens (flavonoids, coumarins, coumestans), on reductive and oxidative 17beta-HSD activity of the human 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD 5).	Flavonoids	88-98	RNA, U1 small nuclear 4	Homo sapiens	184-240
11299000-7	2001	Generally, swainsonine was the least effective whereas the citrus flavonoids, particularly nobiletin, showed the greatest downregulation of secretion of the MMPs.	Flavonoids	66-76	matrix metallopeptidase 2	Homo sapiens	157-161
11170137-2	2001	Recently we showed that treatment of prostate carcinoma DU145 cells with cancer preventive flavonoid silymarin at 100-200 microM doses inhibits erbB1-Shc mitogenic signaling and modulates cell cycle regulators leading to a G1 arrest and inhibition of cell growth and anchorage-independent colony formation.	Flavonoids	91-100	epidermal growth factor receptor	Homo sapiens	144-149
11170137-2	2001	Recently we showed that treatment of prostate carcinoma DU145 cells with cancer preventive flavonoid silymarin at 100-200 microM doses inhibits erbB1-Shc mitogenic signaling and modulates cell cycle regulators leading to a G1 arrest and inhibition of cell growth and anchorage-independent colony formation.	Flavonoids	91-100	SHC adaptor protein 1	Homo sapiens	150-153
11482900-1	2001	Epicatechin, a flavonoid belonging to the group of compounds collectively called catechins, have been reported to possess insulin-like properties.	Flavonoids	15-24	insulin	Homo sapiens	122-129
11166702-4	2001	Moreover, the terpene and flavonoid-free EGb 761 extract, HE 208, although inhibited the Abeta-induced increased glucose uptake, it failed to protect the cells from apoptosis and cytotoxicity induced by Abeta.	Flavonoids	26-35	amyloid beta precursor protein	Rattus norvegicus	89-94
11166702-5	2001	In conclusion, these results indicate that the terpenoid and flavonoid constituents of EGb 761, acting probably in combination with components present in HE 208, are responsible for rescuing the neuronal cells from Abeta-induced apoptosis and cell death; their mechanism of action being distinct of their antioxidant properties.	Flavonoids	61-70	amyloid beta precursor protein	Rattus norvegicus	215-220
11213362-0	2001	Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1.	Flavonoids	81-91	prostaglandin-endoperoxide synthase 2	Homo sapiens	50-66
11213362-2	2001	Moreover, we evaluated flavonoid modulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) enzyme expression by western blot analysis.	Flavonoids	23-32	nitric oxide synthase 2	Homo sapiens	80-84
11213362-2	2001	Moreover, we evaluated flavonoid modulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) enzyme expression by western blot analysis.	Flavonoids	23-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	90-106
11213362-2	2001	Moreover, we evaluated flavonoid modulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) enzyme expression by western blot analysis.	Flavonoids	23-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	108-113
11213362-7	2001	This study suggests that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects.	Flavonoids	68-78	nitric oxide synthase 2	Homo sapiens	39-43
11213362-7	2001	This study suggests that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects.	Flavonoids	68-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
11732607-2	2001	In response to flavonoids excreted by the host plant, rhizobia synthesize Nod factors (NFs) which elicit, at very low concentrations and in a specific manner, various symbiotic responses on the roots of the legume hosts.	Flavonoids	15-25	atrophin 1	Homo sapiens	74-77
11292234-5	2001	All the four isolated flavonoids possessed stronger inhibitory activity (IC50, &lt; 25 microM) than silibinin (IC50, 39.6 microM) on TNF-alpha-induced cell death.	Flavonoids	22-32	tumor necrosis factor	Mus musculus	133-142
11500931-4	2001	Decrease of NO production by flavonoids was consistent with the inhibition on LPS-induced iNOS gene expression by western blotting.	Flavonoids	29-39	nitric oxide synthase 2, inducible	Mus musculus	90-94
11500931-10	2001	These results indicated that combinatorial treatment of L-arginine analogs and flavonoid derivates, such as quercetin pentaacetate, effectively inhibited LPS-induced NO and PGE2 productions, at the same time, inhibited enhanced expressions of iNOS and COX-2 genes.	Flavonoids	79-88	nitric oxide synthase 2, inducible	Mus musculus	243-247
11500931-10	2001	These results indicated that combinatorial treatment of L-arginine analogs and flavonoid derivates, such as quercetin pentaacetate, effectively inhibited LPS-induced NO and PGE2 productions, at the same time, inhibited enhanced expressions of iNOS and COX-2 genes.	Flavonoids	79-88	prostaglandin-endoperoxide synthase 2	Mus musculus	252-257
11123379-5	2001	To determine the mechanisms by which flavonoids inhibit LPS signaling, we used luteolin and determined its ability to interfere with total protein tyrosine phosphorylation as well as Akt phosphorylation and nuclear factor-kappaB activation.	Flavonoids	37-47	toll-like receptor 4	Mus musculus	56-59
11141187-1	2001	The FAH1 and F3H genes encode ferulate-5-hydroxylase and flavanone-3-hydroxylase, which are enzymes in the pathways leading to the synthesis of sinapic acid esters and flavonoids, respectively.	Flavonoids	168-178	ferulic acid 5-hydroxylase 1	Arabidopsis thaliana	4-8
11141187-1	2001	The FAH1 and F3H genes encode ferulate-5-hydroxylase and flavanone-3-hydroxylase, which are enzymes in the pathways leading to the synthesis of sinapic acid esters and flavonoids, respectively.	Flavonoids	168-178	flavanone 3-hydroxylase	Arabidopsis thaliana	13-16
12094622-0	2001	Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides.	Flavonoids	99-108	neurotensin	Homo sapiens	0-11
12094622-0	2001	Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides.	Flavonoids	99-108	epidermal growth factor	Homo sapiens	16-19
11123379-2	2001	In the present study, we compared the ability of several flavonoids to modulate the production of proinflammatory molecules from lipopolysaccharide (LPS)-stimulated macrophages and investigated their mechanism(s) of action.	Flavonoids	57-67	toll-like receptor 4	Mus musculus	149-152
11193416-0	2000	Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid.	Flavonoids	59-68	sucrase-isomaltase	Homo sapiens	14-31
11226036-8	2001	These results indicate that tannic acid inhibited the activity of both acrosin and plasminogen activator and indicates a possible mechanism by which flavonoids exert their antifertility effects.	Flavonoids	149-159	acrosin	Homo sapiens	71-78
11171137-7	2000	Our results indicate that ACL generates the cytosolic pool of acetyl-CoA, which is the substrate required for the biosynthesis of a variety of phytochemicals, including cuticular waxes and flavonoids.	Flavonoids	189-199	acetone-cyanohydrin lyase	Arabidopsis thaliana	26-29
11193416-1	2000	Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1).	Flavonoids	31-41	sucrase-isomaltase	Homo sapiens	88-105
11105561-8	2000	Since nitric oxide (NO) produced by inducible NO synthase (iNOS) plays an important role in inflammatory disorders, inhibition of NO production by these flavonoids may contribute, at least in part, to their anti-inflammatory and immunoregulating potential in vivo.	Flavonoids	153-163	nitric oxide synthase 2, inducible	Mus musculus	36-57
11041882-1	2000	The TRANSPARENT TESTA8 (TT8) locus is involved in the regulation of flavonoid biosynthesis in Arabidopsis.	Flavonoids	68-77	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	16-22
11041882-1	2000	The TRANSPARENT TESTA8 (TT8) locus is involved in the regulation of flavonoid biosynthesis in Arabidopsis.	Flavonoids	68-77	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	24-27
11105561-8	2000	Since nitric oxide (NO) produced by inducible NO synthase (iNOS) plays an important role in inflammatory disorders, inhibition of NO production by these flavonoids may contribute, at least in part, to their anti-inflammatory and immunoregulating potential in vivo.	Flavonoids	153-163	nitric oxide synthase 2, inducible	Mus musculus	59-63
11045600-8	2000	In extrahepatic tissues, renal AHH activity was decreased by wogonin whereas pulmonary AHH, 7-ethoxyresorufin O-deethylation (EROD), and MROD activities were increased by both flavonoids.	Flavonoids	176-186	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	87-90
10975858-6	2000	N-acetyl cysteine and the flavonoid, luteolin, inhibited HO-1 protein expression.	Flavonoids	26-35	heme oxygenase 1	Mus musculus	57-61
10958819-8	2000	The total intake of flavonoids was inversely correlated with the plasma total cholesterol concentration (TC) (r = -0.236, P: &lt; 0.05) and plasma LDL cholesterol concentration (LDL-C) (r = -0.220, P: &lt; 0.05), after the adjustment for age, body mass index and total energy intake.	Flavonoids	20-30	component of oligomeric golgi complex 2	Homo sapiens	147-176
11041882-6	2000	The TT8 protein is required for normal expression of two flavonoid late biosynthetic genes, namely, DIHYDROFLAVONOL 4-REDUCTASE (DFR) and BANYULS (BAN), in Arabidopsis siliques.	Flavonoids	57-66	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	4-7
11041882-6	2000	The TT8 protein is required for normal expression of two flavonoid late biosynthetic genes, namely, DIHYDROFLAVONOL 4-REDUCTASE (DFR) and BANYULS (BAN), in Arabidopsis siliques.	Flavonoids	57-66	dihydroflavonol 4-reductase	Arabidopsis thaliana	100-127
11041882-6	2000	The TT8 protein is required for normal expression of two flavonoid late biosynthetic genes, namely, DIHYDROFLAVONOL 4-REDUCTASE (DFR) and BANYULS (BAN), in Arabidopsis siliques.	Flavonoids	57-66	dihydroflavonol 4-reductase	Arabidopsis thaliana	129-132
11041882-8	2000	Our results suggest that the TT8, TTG1, and TT2 proteins may interact to control flavonoid metabolism in the Arabidopsis seed coat.	Flavonoids	81-90	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	29-32
11041882-8	2000	Our results suggest that the TT8, TTG1, and TT2 proteins may interact to control flavonoid metabolism in the Arabidopsis seed coat.	Flavonoids	81-90	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	34-38
11041882-8	2000	Our results suggest that the TT8, TTG1, and TT2 proteins may interact to control flavonoid metabolism in the Arabidopsis seed coat.	Flavonoids	81-90	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	44-47
10927021-1	2000	Numerous flavonoids are ligands of the aryl hydrocarbon receptor (AHR) and function as AHR antagonists and/or agonists.	Flavonoids	9-19	aryl hydrocarbon receptor	Homo sapiens	39-64
10927021-1	2000	Numerous flavonoids are ligands of the aryl hydrocarbon receptor (AHR) and function as AHR antagonists and/or agonists.	Flavonoids	9-19	aryl hydrocarbon receptor	Homo sapiens	66-69
10927021-1	2000	Numerous flavonoids are ligands of the aryl hydrocarbon receptor (AHR) and function as AHR antagonists and/or agonists.	Flavonoids	9-19	aryl hydrocarbon receptor	Homo sapiens	87-90
10950852-0	2000	Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2.	Flavonoids	55-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	41-47
10945830-0	2000	Efflux of dietary flavonoid quercetin 4"-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2.	Flavonoids	18-27	ATP binding cassette subfamily C member 2	Homo sapiens	113-154
10958819-8	2000	The total intake of flavonoids was inversely correlated with the plasma total cholesterol concentration (TC) (r = -0.236, P: &lt; 0.05) and plasma LDL cholesterol concentration (LDL-C) (r = -0.220, P: &lt; 0.05), after the adjustment for age, body mass index and total energy intake.	Flavonoids	20-30	component of oligomeric golgi complex 2	Homo sapiens	178-183
10972672-1	2000	BACKGROUND: Bioflavonoid quercetin inhibits hydrogen peroxide (H2O2)-induced apoptosis via intervention in the activator protein 1 (AP-1)-mediated apoptotic pathway.	Flavonoids	12-24	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-130
10945831-0	2000	Cellular uptake of dietary flavonoid quercetin 4"-beta-glucoside by sodium-dependent glucose transporter SGLT1.	Flavonoids	27-36	solute carrier family 5 member 1	Homo sapiens	105-110
10945831-2	2000	In fact, our previous studies with the human Caco-2 cell model of intestinal absorption demonstrated that a major dietary flavonoid, quercetin 4"-beta-glucoside, is effluxed by apically expressed multidrug resistance-associated protein-2, potentially masking evidence for active absorption.	Flavonoids	122-131	ATP binding cassette subfamily C member 2	Homo sapiens	196-237
10972672-1	2000	BACKGROUND: Bioflavonoid quercetin inhibits hydrogen peroxide (H2O2)-induced apoptosis via intervention in the activator protein 1 (AP-1)-mediated apoptotic pathway.	Flavonoids	12-24	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
10953044-4	2000	Because bioflavonoids block PAH-induced cell transformation and are structurally similar to AhR ligands, it was postulated that some of them would suppress PAH-induced, AhR-dependent immunotoxicity, possibly through a direct AhR blockade.	Flavonoids	8-21	aryl hydrocarbon receptor	Homo sapiens	169-172
10953044-4	2000	Because bioflavonoids block PAH-induced cell transformation and are structurally similar to AhR ligands, it was postulated that some of them would suppress PAH-induced, AhR-dependent immunotoxicity, possibly through a direct AhR blockade.	Flavonoids	8-21	aryl hydrocarbon receptor	Homo sapiens	169-172
10913616-3	2000	We examined flavonoids ubiquitously expressed in plant foods as one of the best candidates, and found that the subclasses flavones and flavonols suppressed antagonistically the transformation of AhR induced by 1 nM of 2,3,7,8-tetrachlorodibenzo-p-dioxin, without exhibiting agonistic effects that transform AhR.	Flavonoids	12-22	aryl hydrocarbon receptor	Homo sapiens	195-198
10952679-1	2000	The flavonoid genistein has been shown to activate a Cl(-) conductance in various cell types expressing CFTR.	Flavonoids	4-13	CF transmembrane conductance regulator	Homo sapiens	104-108
10953339-0	2000	Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid.	Flavonoids	75-84	BCL2 apoptosis regulator	Homo sapiens	14-19
10920275-0	2000	Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship.	Flavonoids	15-25	prostaglandin-endoperoxide synthase 2	Homo sapiens	29-45
10942316-9	2000	Bioavailability, metabolism, the ability to alter ERalpha distribution in the uterus and the estrogenic potential of parent compound and metabolites may thus contribute to the differences in in vivo estrogenicity of dietary flavonoids.	Flavonoids	224-234	estrogen receptor 1 (alpha)	Mus musculus	50-57
10880051-7	2000	The culture-induced enhanced HSP70 expression can be prevented by addition of either the flavonoid antioxidant quercetin or an antisense oligonucleotide to HSP70.	Flavonoids	89-98	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	29-34
10955529-3	2000	Quantitative structure-activity relationship (QSAR) studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase (PTK) inhibitors were performed, using a large number of molecular descriptors calculated by CODESSA software.	Flavonoids	67-76	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	92-98
10955529-5	2000	The obtained results demonstrate in detail the importance of electrostatic and quantum chemical descriptors for the interaction of flavonoids with the specific p56lck enzymatic active site environment.	Flavonoids	131-141	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-166
10871299-7	2000	The flavonoid compound I3,II8-biapigenin was shown to be a potent, competitive inhibitor of CYP3A4, CYP2C9, and CYP1A2 activities with K(i) values of 0.038, 0.32, and 0.95 microM, respectively.	Flavonoids	4-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	92-98
10871299-7	2000	The flavonoid compound I3,II8-biapigenin was shown to be a potent, competitive inhibitor of CYP3A4, CYP2C9, and CYP1A2 activities with K(i) values of 0.038, 0.32, and 0.95 microM, respectively.	Flavonoids	4-13	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	100-106
10871299-7	2000	The flavonoid compound I3,II8-biapigenin was shown to be a potent, competitive inhibitor of CYP3A4, CYP2C9, and CYP1A2 activities with K(i) values of 0.038, 0.32, and 0.95 microM, respectively.	Flavonoids	4-13	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	112-118
10920275-2	2000	Investigation of the suppressive action of twelve flavonoids of different chemical classes on the transcriptional activity of the COX-2 gene in human colon cancer DLD-1 cells using a reporter gene assay have revealed quercetin to be the most potent suppressor of COX-2 transcription (IC50 = 10.5 microM), while catechin and epicatechin showed weak activity (IC50 = 415.3 microM).	Flavonoids	50-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	130-135
10920275-2	2000	Investigation of the suppressive action of twelve flavonoids of different chemical classes on the transcriptional activity of the COX-2 gene in human colon cancer DLD-1 cells using a reporter gene assay have revealed quercetin to be the most potent suppressor of COX-2 transcription (IC50 = 10.5 microM), while catechin and epicatechin showed weak activity (IC50 = 415.3 microM).	Flavonoids	50-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	263-268
10861967-6	2000	This result indicates that the stereoscopic structure between the C-3 group and the B ring of flavonoids as well as substituents at the C-3 position make a contribution to radical scavenging activity.	Flavonoids	94-104	complement C3	Homo sapiens	66-69
10841772-5	2000	Interestingly, yeast Pdr5p interacted with flavonoids recently found to bind to cancer cell P-glycoprotein and to the protozoan parasite multidrug transporter.	Flavonoids	43-53	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	21-26
10784426-0	2000	Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line.	Flavonoids	4-14	PML nuclear body scaffold	Homo sapiens	81-103
10801933-6	2000	Because GLUT 1 and GLUT 3 transport dehydroascorbic acid, the inhibition of dehydroascorbic acid uptake by flavonoids was investigated by using Chinese hamster ovary cells overexpressing rat GLUT 1 or human GLUT 3.	Flavonoids	107-117	solute carrier family 2, facilitated glucose transporter member 1	Cricetulus griseus	8-14
10801933-6	2000	Because GLUT 1 and GLUT 3 transport dehydroascorbic acid, the inhibition of dehydroascorbic acid uptake by flavonoids was investigated by using Chinese hamster ovary cells overexpressing rat GLUT 1 or human GLUT 3.	Flavonoids	107-117	solute carrier family 2 member 1	Rattus norvegicus	191-197
10758153-0	2000	Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia.	Flavonoids	8-21	lysine methyltransferase 2A	Homo sapiens	45-48
10758153-8	2000	These results suggest that maternal ingestion of bioflavonoids may induce MLL breaks and potentially translocations in utero leading to infant and early childhood leukemia.	Flavonoids	49-62	lysine methyltransferase 2A	Homo sapiens	74-77
10760502-3	2000	In this work, the in vitro glucuronidation of the common dietary flavonoids quercetin and kaempferol by human UDP-glucuronosyltransferase microsomes (UGT-1A9) was investigated using HPLC and LC-MS.	Flavonoids	65-75	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	150-157
10781868-0	2000	Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1.	Flavonoids	0-13	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	81-87
10781868-1	2000	Interactions of six naturally occurring flavonoids (acacetin, diosmetin, eriodictyol, hesperetin, homoeriodictyol, and naringenin) with human cytochrome P450 (CYP1) enzymes were studied.	Flavonoids	40-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	159-163
10784426-2	2000	These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2 x 10(-4) M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens.	Flavonoids	10-20	PML nuclear body scaffold	Homo sapiens	88-110
10784426-2	2000	These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2 x 10(-4) M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens.	Flavonoids	10-20	CEA cell adhesion molecule 8	Homo sapiens	241-247
10784426-2	2000	These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2 x 10(-4) M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens.	Flavonoids	10-20	CD14 molecule	Homo sapiens	252-257
10801247-1	2000	BACKGROUND: Tangeretin is a flavonoid that stimulates the catalytic activity of cytochrome P450 3A4 (CYP3A4) and is found in high levels in tangerine juice.	Flavonoids	28-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
10708754-9	2000	Finally, (iso)flavonoid-induced MRP1 ATPase activity is not synergistically increased by the presence of GSH.	Flavonoids	14-23	ATP binding cassette subfamily B member 1	Homo sapiens	32-36
10995031-0	2000	Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase.	Flavonoids	21-31	arachidonate 15-lipoxygenase	Homo sapiens	95-110
10995031-9	2000	These results emphasize the inhibitory effect of the flavonoids quercetin and epicatechin on 15-lipoxygenase-mediated LDL lipid peroxidation.	Flavonoids	53-63	arachidonate 15-lipoxygenase	Homo sapiens	93-108
10709057-8	2000	CONCLUSION: Micronized purified flavonoid fraction treatment for 60 days seems to decrease the surface expression of CD62L by neutrophils and by monocytes.	Flavonoids	32-41	selectin L	Homo sapiens	117-122
10752639-0	2000	In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus.	Flavonoids	56-66	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	29-33
30754792-7	2000	It can be argued that the distribution of beta-glucuronidase in this plant is closely linked with the defense against pathogens: it is a starting key enzyme which may act together with the flavonoids, which play an important role as a proton donor for the detoxification metabolism of H2O2.	Flavonoids	189-199	glucuronidase beta	Homo sapiens	42-60
10752639-4	2000	Additionally, preliminary studies have shown these flavonoids (at 100 microM) to be inhibitory of P450-mediated activation reactions in a variety of in vitro systems.	Flavonoids	51-61	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	98-102
10752639-12	2000	In contrast, the most effective inhibitors of CYP1A2 acetanilide 4-hydroxylase activity were the two prenylated flavonoids, 8-prenylnaringenin (8PN) and isoxanthohumol (IX), which produced &gt; 90% inhibition when added at concentrations of 10 microM.	Flavonoids	112-122	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	46-52
10692580-0	2000	Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.	Flavonoids	8-17	lactase	Homo sapiens	66-73
10692580-0	2000	Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.	Flavonoids	8-17	lactase	Homo sapiens	82-109
10737704-1	2000	The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line.	Flavonoids	77-87	crystallin, zeta	Mus musculus	145-162
10752639-19	2000	These results suggest that the hop flavonoids are potent and selective inhibitors of human cytochrome P450 and warrant further in vivo investigations.	Flavonoids	35-45	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	102-106
11216487-4	2000	In this study, flavonoids at various concentrations were treated to a rat cytosolic fraction containing AhR before adding 1 nM TCDD.	Flavonoids	15-25	aryl hydrocarbon receptor	Rattus norvegicus	104-107
10769666-4	2000	Flavonoids induced apoptotic cell death characterized by DNA fragmentation (as identified by TUNEL method) and activation of caspase(s) (as identified by degradation products of cytokeratin 18 with M30 monoclonal antibody).	Flavonoids	0-10	keratin 18	Homo sapiens	178-192
10652242-0	2000	The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes.	Flavonoids	4-13	vitamin D receptor	Homo sapiens	34-52
10723772-6	2000	E.g. 3,4-dihydroxyphenylacetic acid and 4-methylcatechol (urinary metabolites of flavonoids) also inhibited both APN and ACE activity, but not NEP activity.	Flavonoids	81-91	alanyl aminopeptidase, membrane	Homo sapiens	113-116
10723772-6	2000	E.g. 3,4-dihydroxyphenylacetic acid and 4-methylcatechol (urinary metabolites of flavonoids) also inhibited both APN and ACE activity, but not NEP activity.	Flavonoids	81-91	angiotensin I converting enzyme	Homo sapiens	121-124
10673101-3	2000	The resulting isoprenoid dehydrosilybins were shown to display high in vitro affinities for direct binding to P-glycoprotein, which ranged them among the best flavonoids ever tested.	Flavonoids	159-169	ATP binding cassette subfamily B member 1	Homo sapiens	110-124
10620351-0	2000	Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer.	Flavonoids	24-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	94-100
10620351-2	2000	To investigate at the molecular level the ability of flavonoids to inhibit tumor-promoting activity, we developed a cell line designed to screen for flavonoids that block the tumor promoter-mediated induction of activator protein-1 (AP-1) transcriptional activity.	Flavonoids	53-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	212-231
10620351-2	2000	To investigate at the molecular level the ability of flavonoids to inhibit tumor-promoting activity, we developed a cell line designed to screen for flavonoids that block the tumor promoter-mediated induction of activator protein-1 (AP-1) transcriptional activity.	Flavonoids	53-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	233-237
10620351-2	2000	To investigate at the molecular level the ability of flavonoids to inhibit tumor-promoting activity, we developed a cell line designed to screen for flavonoids that block the tumor promoter-mediated induction of activator protein-1 (AP-1) transcriptional activity.	Flavonoids	149-159	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	212-231
10620351-2	2000	To investigate at the molecular level the ability of flavonoids to inhibit tumor-promoting activity, we developed a cell line designed to screen for flavonoids that block the tumor promoter-mediated induction of activator protein-1 (AP-1) transcriptional activity.	Flavonoids	149-159	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	233-237
10650074-3	2000	The eight flavonoids, including new compounds (1-3), patulitrin (7), nepitrin (8), axillarin (10), patuletin (11), and luteolin (12), showed profound antioxidant activity in DPPH assay and cytochrome-c reduction assay using HL-60 cell culture system.	Flavonoids	10-20	cytochrome c, somatic	Homo sapiens	189-201
10648013-0	2000	A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts.	Flavonoids	9-18	matrix metalloproteinase-9	Oryctolagus cuniculus	76-102
10648013-0	2000	A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts.	Flavonoids	9-18	matrix metalloproteinase-9	Oryctolagus cuniculus	103-115
10714603-0	2000	Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells.	Flavonoids	48-58	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-40
11525602-0	2000	Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms.	Flavonoids	44-53	estrogen receptor 1	Homo sapiens	77-94
11525602-2	2000	We have performed the present study to characterize the estrogenic and antiestrogenic activity of flavonoids in the estrogen receptor (ER)-positive MCF-7 human breast cancer cell line.	Flavonoids	98-108	estrogen receptor 1	Homo sapiens	116-133
11525602-2	2000	We have performed the present study to characterize the estrogenic and antiestrogenic activity of flavonoids in the estrogen receptor (ER)-positive MCF-7 human breast cancer cell line.	Flavonoids	98-108	estrogen receptor 1	Homo sapiens	135-137
10714603-3	2000	METHODS: The induction of UGT by flavonoid pretreatment was studied both in the intact cells and cell homogenates, measured as the glucuronidation of chrysin, and by immunoblot analysis of the UGT 1A protein.	Flavonoids	33-42	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	193-199
11142097-3	2000	The proliferation of LNCaP and PC3 cells was preferentially inhibited by flavonoids (catechin, epicatechin, and quercetin), whereas resveratrol was the most potent inhibitor of DU145 cell growth.	Flavonoids	73-83	BTG anti-proliferation factor 2	Homo sapiens	31-34
10714603-3	2000	METHODS: The induction of UGT by flavonoid pretreatment was studied both in the intact cells and cell homogenates, measured as the glucuronidation of chrysin, and by immunoblot analysis of the UGT 1A protein.	Flavonoids	33-42	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	26-29
10607476-3	1999	Addition of catalase protected DNA from the strand breaks caused by flavonoids.	Flavonoids	68-78	catalase	Bos taurus	12-20
10622719-3	1999	In this study, we showed that quercetin, a naturally occurring flavonoid, in association with the agonistic anti-CD95 monoclonal antibody, increases DNA fragmentation and caspase-3 activity in HPB-ALL cells.	Flavonoids	63-72	caspase 3	Homo sapiens	171-180
10961741-7	1999	The incubation with Rp-cAMPS (10 and 100 microM) 30 min prior to KCl shifted the dose-response curve of the flavonoids to the right, increasing their IC50 up to 27.8 +/- 3.8 and 31.9 +/- 7.3 microM, respectively, for genistein; 24.7 +/- 0.2 and 19.6 +/- 4.9 microM, respectively, for kaempferol; 18.8 +/- 2.2 and 18.4 +/- 1.5 microM, respectively, for quercetin.	Flavonoids	108-118	calmodulin 2, pseudogene 1	Rattus norvegicus	23-28
10634908-0	2000	Expression profiling of the maize flavonoid pathway genes controlled by estradiol-inducible transcription factors CRC and P. To determine the scope of gene expression controlled by the maize transcription factors C1/R and P, which are responsible for activating flavonoid synthesis, we used GeneCalling, an open-ended, gel-based, mRNA-profiling technology, to analyze cell suspension lines of the maize inbred Black Mexican Sweet (BMS) that harbored estradiol-inducible versions of these factors.	Flavonoids	34-43	anthocyanin regulatory C1 protein	Zea mays	213-223
10634908-0	2000	Expression profiling of the maize flavonoid pathway genes controlled by estradiol-inducible transcription factors CRC and P. To determine the scope of gene expression controlled by the maize transcription factors C1/R and P, which are responsible for activating flavonoid synthesis, we used GeneCalling, an open-ended, gel-based, mRNA-profiling technology, to analyze cell suspension lines of the maize inbred Black Mexican Sweet (BMS) that harbored estradiol-inducible versions of these factors.	Flavonoids	262-271	anthocyanin regulatory C1 protein	Zea mays	213-223
11247161-5	2000	In animals received T-2 toxin against a background of a diet with addition a flour from seeds of milk thistle with high contents of flavonoids, described morphological changes were expressed to a lesser degree and were observed less often.	Flavonoids	132-142	brachyury 2	Rattus norvegicus	20-23
10569809-0	1999	Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion.	Flavonoids	30-39	prostaglandin-endoperoxide synthase 2	Mus musculus	170-186
10569809-0	1999	Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion.	Flavonoids	30-39	interleukin 1 alpha	Mus musculus	191-209
10425183-7	1999	These data indicate that QCT, a flavonoid previously reported to inhibit HIV replication, also targets Vpr, implicating that MIT-23 cell provides a novel strategy for screening compounds possessing anti-Vpr activity which would be in turn utilized for clarifying the mechanism of Vpr function.	Flavonoids	32-41	Vpr	Human immunodeficiency virus 1	103-106
10558914-7	1999	Thus, activation of eIF2alpha kinases appears to be a mechanism by which flavonoids can inhibit the growth of tumor and leukemia cells.	Flavonoids	73-83	eukaryotic translation initiation factor 2A	Homo sapiens	20-29
10586425-0	1999	Protective effect of a bioflavonoid proanthocyanidin-BP1 in glycerol-induced acute renal failure in the rat: renal stereological study.	Flavonoids	23-35	Blood pressure QTL 1	Rattus norvegicus	36-56
10586425-3	1999	In this study the protective effect of a new bioflavonoid proanthocyanidin-BP1 (BP1), extracted from seeds of grapes, was evaluated in glycerol-induced ARF in rats.	Flavonoids	45-57	Blood pressure QTL 1	Rattus norvegicus	58-78
10586425-3	1999	In this study the protective effect of a new bioflavonoid proanthocyanidin-BP1 (BP1), extracted from seeds of grapes, was evaluated in glycerol-induced ARF in rats.	Flavonoids	45-57	Blood pressure QTL 1	Rattus norvegicus	75-78
10506109-13	1999	This study suggests that modulation of COX-2 and iNOS by apigenin and related flavonoids may be important in the prevention of carcinogenesis and inflammation.	Flavonoids	78-88	cytochrome c oxidase II, mitochondrial	Mus musculus	39-44
10506109-13	1999	This study suggests that modulation of COX-2 and iNOS by apigenin and related flavonoids may be important in the prevention of carcinogenesis and inflammation.	Flavonoids	78-88	nitric oxide synthase 2, inducible	Mus musculus	49-53
10497143-7	1999	The catalytic activity of stably expressed UGT1A8 toward catechol estrogens, coumarins, flavonoids, anthraquinones, and phenolic compounds was much higher than that of UGT1A10.	Flavonoids	88-98	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	43-49
10497143-7	1999	The catalytic activity of stably expressed UGT1A8 toward catechol estrogens, coumarins, flavonoids, anthraquinones, and phenolic compounds was much higher than that of UGT1A10.	Flavonoids	88-98	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	168-175
10673981-0	1999	Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells.	Flavonoids	47-57	cytochrome c, somatic	Homo sapiens	66-78
10673981-0	1999	Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells.	Flavonoids	47-57	caspase 9	Homo sapiens	105-114
10673981-0	1999	Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells.	Flavonoids	47-57	caspase 3	Homo sapiens	119-128
10673981-5	1999	Treatment with flavonoids (60 microM) caused a rapid induction of caspase-3 activity and stimulated proteolytic cleavage of poly-(ADP-ribose) polymerase (PARP).	Flavonoids	15-25	caspase 3	Homo sapiens	66-75
10673981-5	1999	Treatment with flavonoids (60 microM) caused a rapid induction of caspase-3 activity and stimulated proteolytic cleavage of poly-(ADP-ribose) polymerase (PARP).	Flavonoids	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	124-152
10673981-5	1999	Treatment with flavonoids (60 microM) caused a rapid induction of caspase-3 activity and stimulated proteolytic cleavage of poly-(ADP-ribose) polymerase (PARP).	Flavonoids	15-25	poly(ADP-ribose) polymerase 1	Homo sapiens	154-158
10673981-6	1999	Furthermore, these flavonoids induced loss of mitochondrial transmembrane potential, elevation of reactive oxygen species (ROS) production, release of mitochondrial cytochrome c into the cytosol, and subsequent induction of procaspase-9 processing.	Flavonoids	19-29	cytochrome c, somatic	Homo sapiens	165-177
10673981-8	1999	These results suggest that flavonoid-induced apoptosis is stimulated by the release of cytochrome c to the cytosol, by procaspase-9 processing, and through a caspase-3-dependent mechanism.	Flavonoids	27-36	cytochrome c, somatic	Homo sapiens	87-99
10673981-8	1999	These results suggest that flavonoid-induced apoptosis is stimulated by the release of cytochrome c to the cytosol, by procaspase-9 processing, and through a caspase-3-dependent mechanism.	Flavonoids	27-36	caspase 3	Homo sapiens	158-167
10493518-1	1999	Flavopiridol is a novel flavonoid that induces cell cycle arrest at different stages of the cell cycle because of the inhibition of cyclin-dependent kinases (cdks).	Flavonoids	24-33	cyclin dependent kinase 2	Homo sapiens	158-162
10496352-2	1999	In this study we show that flavopiridol, a synthetic flavonoid currently studied in phase 1 trials for its antiproliferative characteristics, interacts with MRP1 in a potent way.	Flavonoids	53-62	ATP binding cassette subfamily B member 1	Homo sapiens	157-161
10656621-6	1999	We also developed gel activity assays to determine the specific activities of CAT and Cu/Zn SOD in flavonoid-treated Caco-2 cells.	Flavonoids	99-108	catalase	Homo sapiens	78-81
10656621-6	1999	We also developed gel activity assays to determine the specific activities of CAT and Cu/Zn SOD in flavonoid-treated Caco-2 cells.	Flavonoids	99-108	superoxide dismutase 1	Homo sapiens	92-95
10541287-0	1999	Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB.	Flavonoids	0-12	chemokine (C-C motif) ligand 2	Mus musculus	84-118
10541287-2	1999	This report describes a novel potential of bioflavonoid quercetin as an inhibitor of monocyte chemoattractant protein-1 (MCP-1) in glomerular cells.	Flavonoids	43-55	chemokine (C-C motif) ligand 2	Mus musculus	85-119
10541287-2	1999	This report describes a novel potential of bioflavonoid quercetin as an inhibitor of monocyte chemoattractant protein-1 (MCP-1) in glomerular cells.	Flavonoids	43-55	chemokine (C-C motif) ligand 2	Mus musculus	121-126
10506109-2	1999	In this study, we investigated the effect of various flavonoids and (-)-epigallocatechin-3-gallate on the activities of inducible cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.	Flavonoids	53-63	cytochrome c oxidase II, mitochondrial	Mus musculus	146-151
10506109-2	1999	In this study, we investigated the effect of various flavonoids and (-)-epigallocatechin-3-gallate on the activities of inducible cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.	Flavonoids	53-63	nitric oxide synthase 2, inducible	Mus musculus	157-188
10550269-0	1999	Plasma VEGF as a marker of therapy in patients with chronic venous disease treated with oral micronised flavonoid fraction - a pilot study.	Flavonoids	104-113	vascular endothelial growth factor A	Homo sapiens	7-11
10550269-1	1999	AIM: to study the effect on plasma vascular endothelial growth factor (VEGF) levels of oral purified flavonoid fraction treatment for sixty days in patients with chronic venous disease (CVD).	Flavonoids	101-110	vascular endothelial growth factor A	Homo sapiens	35-69
10550269-1	1999	AIM: to study the effect on plasma vascular endothelial growth factor (VEGF) levels of oral purified flavonoid fraction treatment for sixty days in patients with chronic venous disease (CVD).	Flavonoids	101-110	vascular endothelial growth factor A	Homo sapiens	71-75
10550269-7	1999	RESULTS: VEGF levels decreased in patients with stage C4 CVD after treatment with purified micronised flavonoid fraction treatment (98 pg/ml to 57 pg/ml).	Flavonoids	102-111	vascular endothelial growth factor A	Homo sapiens	9-13
10550269-10	1999	Plasma VEGF protein decreases in patients with CVD-induced dermatologic changes following treatment with purified micronised flavonoid fraction.	Flavonoids	125-134	vascular endothelial growth factor A	Homo sapiens	7-11
10440930-0	1999	Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells.	Flavonoids	74-84	tumor necrosis factor	Homo sapiens	15-23
10440930-0	1999	Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells.	Flavonoids	74-84	nuclear factor kappa B subunit 1	Homo sapiens	33-41
10440930-4	1999	In this study, the effects of flavonoids on NFkappaB/inhibitor-kappaB (IkappaB) system in ECV304 cells activated with tumor necrosis factor-alpha (TNFalpha) were examined.	Flavonoids	30-40	nuclear factor kappa B subunit 1	Homo sapiens	44-52
10440930-4	1999	In this study, the effects of flavonoids on NFkappaB/inhibitor-kappaB (IkappaB) system in ECV304 cells activated with tumor necrosis factor-alpha (TNFalpha) were examined.	Flavonoids	30-40	tumor necrosis factor	Homo sapiens	118-145
10440930-4	1999	In this study, the effects of flavonoids on NFkappaB/inhibitor-kappaB (IkappaB) system in ECV304 cells activated with tumor necrosis factor-alpha (TNFalpha) were examined.	Flavonoids	30-40	tumor necrosis factor	Homo sapiens	147-155
10440930-8	1999	Therefore we conclude that flavonoids may be of therapeutic value for vascular disease through down regulation of NFkappaB/IkappaB system.	Flavonoids	27-37	nuclear factor kappa B subunit 1	Homo sapiens	114-122
10504573-0	1999	Cloning and expression of a cDNA encoding betanidin 5-O-glucosyltransferase, a betanidin- and flavonoid-specific enzyme with high homology to inducible glucosyltransferases from the Solanaceae.	Flavonoids	94-103	UDP-glucose flavonoid 3-O-glucosyltransferase 6-like	Nicotiana tabacum	56-75
10425183-7	1999	These data indicate that QCT, a flavonoid previously reported to inhibit HIV replication, also targets Vpr, implicating that MIT-23 cell provides a novel strategy for screening compounds possessing anti-Vpr activity which would be in turn utilized for clarifying the mechanism of Vpr function.	Flavonoids	32-41	Vpr	Human immunodeficiency virus 1	203-206
10425183-7	1999	These data indicate that QCT, a flavonoid previously reported to inhibit HIV replication, also targets Vpr, implicating that MIT-23 cell provides a novel strategy for screening compounds possessing anti-Vpr activity which would be in turn utilized for clarifying the mechanism of Vpr function.	Flavonoids	32-41	Vpr	Human immunodeficiency virus 1	203-206
10426807-5	1999	With the exception of apigenin, the flavonoids under study induced G(1) arrest in both 5L and BP8 cells when used at concentrations at which they functioned as AHR agonists, but not antagonists.	Flavonoids	36-46	BP8	Homo sapiens	94-97
10417314-9	1999	Monocarboxylate transport via MCT2 could be inhibited by alpha-cyano-4-hydroxycinnamate, anion-channel inhibitors and flavonoids.	Flavonoids	118-128	solute carrier family 16 member 7	Rattus norvegicus	30-34
10426807-0	1999	Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor.	Flavonoids	41-51	aryl hydrocarbon receptor	Homo sapiens	71-96
10426807-5	1999	With the exception of apigenin, the flavonoids under study induced G(1) arrest in both 5L and BP8 cells when used at concentrations at which they functioned as AHR agonists, but not antagonists.	Flavonoids	36-46	aryl hydrocarbon receptor	Homo sapiens	160-163
10426807-1	1999	Some flavonoids are ligands of the aryl hydrocarbon receptor (AHR) and cause cell cycle arrest.	Flavonoids	5-15	aryl hydrocarbon receptor	Homo sapiens	35-60
10426807-1	1999	Some flavonoids are ligands of the aryl hydrocarbon receptor (AHR) and cause cell cycle arrest.	Flavonoids	5-15	aryl hydrocarbon receptor	Homo sapiens	62-65
10441778-3	1999	The activity of catalase was found to be significantly enhanced in the tissues of normal and cholesterol fed rats administered 1 mg flavonoid from brinjal/100 g BW/day.	Flavonoids	132-141	catalase	Rattus norvegicus	16-24
10454753-12	1999	Therefore flavonoids constitute a new promising class of bifunctional modulators of Pgp.	Flavonoids	10-20	ATP binding cassette subfamily B member 1	Homo sapiens	84-87
10441778-5	1999	The elevated levels of glutathione and significantly stimulated activity of catalase may be responsible for the antioxidant effect of these flavonoids.	Flavonoids	140-150	catalase	Rattus norvegicus	76-84
10417722-5	1999	Based on their enzymatic properties, expression characteristics and evolutionary relationships, At4CL3 is likely to participate in the biosynthetic pathway leading to flavonoids whereas At4CL1 and At4CL2 are probably involved in lignin formation and in the production of additional phenolic compounds other than flavonoids.	Flavonoids	312-322	4-coumarate:CoA ligase 1	Arabidopsis thaliana	186-192
10432202-3	1999	Flavonoids extracted from pcpso showed 31-44% inhibition of sheep cyclooxygenase and 69-81% inhibition of soybean lipoxygenase.	Flavonoids	0-10	linoleate 9S-lipoxygenase-4	Glycine max	114-126
10432202-4	1999	Flavonoids extracted from pfj showed 21-30% inhibition of soybean lipoxygenase though no significant inhibition of sheep cyclooxygenase.	Flavonoids	0-10	linoleate 9S-lipoxygenase-4	Glycine max	66-78
10417722-5	1999	Based on their enzymatic properties, expression characteristics and evolutionary relationships, At4CL3 is likely to participate in the biosynthetic pathway leading to flavonoids whereas At4CL1 and At4CL2 are probably involved in lignin formation and in the production of additional phenolic compounds other than flavonoids.	Flavonoids	312-322	4-coumarate:CoA ligase 2	Arabidopsis thaliana	197-203
10405873-3	1999	The flavonoid quercetin is one of very few molecules that inhibit RBL cell proliferation and constitutive histamine release; it also induces synthesis of rat mast cell protease (RMCP) II and accumulation of secretory granules.	Flavonoids	4-13	mast cell protease 2	Rattus norvegicus	178-186
10415793-0	1999	The citrus flavonoid nobiletin suppresses the production and gene expression of matrix metalloproteinases-9/gelatinase B in rabbit synovial cells.	Flavonoids	11-20	matrix metalloproteinase-9	Oryctolagus cuniculus	108-120
10399192-0	1999	In vitro effects of selected flavonoids on the 5"-nucleotidase activity.	Flavonoids	29-39	5'-nucleotidase ecto	Homo sapiens	47-62
10394944-3	1999	The pattern of flavonoid enzyme expression over the course of seedling development was consistent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), and flavonol synthase (FLS) are encoded by "early" genes while leucoanthocyanidin dioxygenase (LDOX) is encoded by a "late" gene.	Flavonoids	15-24	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	136-153
10405973-5	1999	Furthermore, our 14C-acetate-labeling studies showed a 50% reduction in cholesteryl ester synthesis in the presence of either flavonoid, which could account for the reduction in net apoB secretion caused by incubation with these compounds.	Flavonoids	126-135	apolipoprotein B	Homo sapiens	182-186
10470145-2	1999	In this study, we tested the cytotoxicity of those flavonoids to human cancer cells including P-glycoprotein (Pgp)-expressing HCT15 cells and its multidrug resistant subline, HCT15/CL02 cells.	Flavonoids	51-61	ATP binding cassette subfamily B member 1	Homo sapiens	94-108
10470145-2	1999	In this study, we tested the cytotoxicity of those flavonoids to human cancer cells including P-glycoprotein (Pgp)-expressing HCT15 cells and its multidrug resistant subline, HCT15/CL02 cells.	Flavonoids	51-61	ATP binding cassette subfamily B member 1	Homo sapiens	110-113
10470145-5	1999	We also investigated that the flavonoids could modulate the Pgp action.	Flavonoids	30-40	ATP binding cassette subfamily B member 1	Homo sapiens	60-63
10454206-4	1999	Flavopiridol is a semisynthetic flavonoid that emerged from an empirical screening program as a potent antiproliferative agent that mechanistic studies demonstrated to directly inhibit CDKs 1, 2, and 4 as a competitive ATP site antagonist.	Flavonoids	32-41	cyclin dependent kinase 2	Homo sapiens	185-189
12712718-0	1999	[Inhibition of human breast cancer cell line BCap-37 by flavonoid extract of wheat germ in vitro].	Flavonoids	56-65	prohibitin 2	Homo sapiens	45-52
12712718-2	1999	Flavonoid extract of wheat germ resulted to a dose-dependent, time-dependent growth inhibition, reduction of colony and 3H-thymiding incorporation in DNA of human breast cancer cell BCap-37.	Flavonoids	0-9	prohibitin 2	Homo sapiens	182-189
10384728-7	1999	Analysis of pigment accumulation and the study of expression patterns of genes involved in flavonoid biosynthesis in tt15 plants and seeds indicated a seed-specific phenotype.	Flavonoids	91-100	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	117-121
10394944-3	1999	The pattern of flavonoid enzyme expression over the course of seedling development was consistent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), and flavonol synthase (FLS) are encoded by "early" genes while leucoanthocyanidin dioxygenase (LDOX) is encoded by a "late" gene.	Flavonoids	15-24	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	161-179
10394944-3	1999	The pattern of flavonoid enzyme expression over the course of seedling development was consistent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), and flavonol synthase (FLS) are encoded by "early" genes while leucoanthocyanidin dioxygenase (LDOX) is encoded by a "late" gene.	Flavonoids	15-24	flavanone 3-hydroxylase	Arabidopsis thaliana	212-215
10394944-3	1999	The pattern of flavonoid enzyme expression over the course of seedling development was consistent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), and flavonol synthase (FLS) are encoded by "early" genes while leucoanthocyanidin dioxygenase (LDOX) is encoded by a "late" gene.	Flavonoids	15-24	flavonol synthase 1	Arabidopsis thaliana	222-239
10394944-3	1999	The pattern of flavonoid enzyme expression over the course of seedling development was consistent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), and flavonol synthase (FLS) are encoded by "early" genes while leucoanthocyanidin dioxygenase (LDOX) is encoded by a "late" gene.	Flavonoids	15-24	flavonol synthase 1	Arabidopsis thaliana	241-244
10394944-3	1999	The pattern of flavonoid enzyme expression over the course of seedling development was consistent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), and flavonol synthase (FLS) are encoded by "early" genes while leucoanthocyanidin dioxygenase (LDOX) is encoded by a "late" gene.	Flavonoids	15-24	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	313-317
10086329-7	1999	This flavonoid had no effect on LPS-induced TNF-alpha mRNA, but decreased LPS-stimulated TNF-alpha release, as measured by ELISA.	Flavonoids	5-14	tumor necrosis factor	Homo sapiens	89-98
10406482-7	1999	Additionally, the flavonoid phytoestrogens genistein and naringenin were also identified as hSHBG ligands, whereas their glucoside derivatives, genistin and naringin, had no binding activity for hSHBG.	Flavonoids	18-27	sex hormone binding globulin	Homo sapiens	92-97
10234737-1	1999	In this study, the synthesis of new flavonoid derivatives, which possess a 1,4-dihydropyridine (1,4-DHP) moiety on the phenyl ring of flavone were realized.	Flavonoids	36-45	dihydropyrimidinase	Homo sapiens	100-103
10232833-11	1999	Antioxidants such as the flavonoids glabridin or quercetin, when present during LDL oxidation in the presence of PON, reduced the amount of lipoprotein-associated lipid peroxides and preserved PON activities, including its ability to hydrolyze Ox-LDL cholesteryl linoleate hydroperoxides.	Flavonoids	25-35	paraoxonase 1	Homo sapiens	113-116
10232833-11	1999	Antioxidants such as the flavonoids glabridin or quercetin, when present during LDL oxidation in the presence of PON, reduced the amount of lipoprotein-associated lipid peroxides and preserved PON activities, including its ability to hydrolyze Ox-LDL cholesteryl linoleate hydroperoxides.	Flavonoids	25-35	paraoxonase 1	Homo sapiens	193-196
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Flavonoids	15-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-76
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Flavonoids	15-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	78-81
9922261-8	1999	Disruption of the flavonoid-inducible nolL gene, which is preceded by a nod box, results in the synthesis of NodNGR factors that lack the 3-O- or 4-O-acetate groups.	Flavonoids	18-27	nodulation protein NolL	Sinorhizobium fredii NGR234	38-42
10211581-3	1999	Despite their lack of strict specificity, some flavonoids provide valuable bases for the design of analogues that could be used to specifically block particular isoforms of PI 3-kinase or PKC and their downstream-dependent cellular responses.	Flavonoids	47-57	proline rich transmembrane protein 2	Homo sapiens	188-191
10188978-9	1999	The flavonoids may be of value for inhibiting the enhanced expression of iNOS in inflammation through down-regulation of NFkappaB binding activity.	Flavonoids	4-14	nitric oxide synthase 2, inducible	Mus musculus	73-77
10188978-9	1999	The flavonoids may be of value for inhibiting the enhanced expression of iNOS in inflammation through down-regulation of NFkappaB binding activity.	Flavonoids	4-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-129
10573180-3	1999	Kinetic studies of the PST activity and the inhibitory effects of flavonoids on the P-form of PST activity (using Hanes-Wolf and Dixon plots) show low Km and Ki values.	Flavonoids	66-76	sulfotransferase family 1A member 1	Homo sapiens	94-97
10218133-8	1999	These in vitro data supported the hypothesis that certain dietary components, possibly flavonoid-related compounds, may influence Pgp"s function in intestine and thus increase etoposide"s absorption.	Flavonoids	87-96	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	130-133
10453447-8	1999	The flavonoid transiently inhibited EGF receptor phosphorylation but had only little effect on other signaling molecules.	Flavonoids	4-13	epidermal growth factor	Homo sapiens	36-39
9845970-1	1998	Molecular modeling studies were conducted on various chemically diverse classes of human A3 adenosine receptor antagonists (hA3ANTs), such as adenines, xanthines, triazoloquinazolines, flavonoids, thiazolopyridines, 6-phenyl-1, 4-dihydropyridines, and 6-phenylpyridines.	Flavonoids	185-195	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	89-91
10578483-6	1999	The effect of the flavonoids on the activities of the antioxidant enzymes catalase (EC 1.11.1.6) and superoxide dismutase (EC 1.15.1.1) and on DNA integrity was assessed.	Flavonoids	18-28	catalase	Homo sapiens	74-82
10608619-3	1999	Quercetin, a plant flavonoid, exhibits antineoplastic activity and inhibits PI 4-kinase (EC 2.7.1.67) and PIP 5-kinase (EC 2.7.1.68) activity.	Flavonoids	19-28	serpin family A member 4	Homo sapiens	76-80
9860924-5	1998	In addition, the location of P450 3A4 residues capable of influencing homotropic stimulation by substrates and heterotropic stimulation by flavonoids has been identified.	Flavonoids	139-149	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	29-33
9862414-0	1998	Selective inhibition of NF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2.	Flavonoids	52-61	nuclear factor kappa B subunit 1	Homo sapiens	24-33
9862414-2	1998	The bioflavonoid silymarin is found to potently suppress both nuclear factor kappa-B (NF-kappaB)-DNA binding activity and its dependent gene expression induced by okadaic acid in the hepatoma cell line HepG2.	Flavonoids	4-16	nuclear factor kappa B subunit 1	Homo sapiens	62-84
9862414-2	1998	The bioflavonoid silymarin is found to potently suppress both nuclear factor kappa-B (NF-kappaB)-DNA binding activity and its dependent gene expression induced by okadaic acid in the hepatoma cell line HepG2.	Flavonoids	4-16	nuclear factor kappa B subunit 1	Homo sapiens	86-95
9929167-0	1998	Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonoids.	Flavonoids	64-74	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
9929167-0	1998	Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonoids.	Flavonoids	64-74	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	14-49
9929167-3	1998	Using this method, the inhibitory effect of various flavonoids, including flavone, flavanone and isoflavone, on the human placental aromatase and 17beta-hydroxysteroid dehydrogenase was studied.	Flavonoids	52-62	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	132-141
9929167-3	1998	Using this method, the inhibitory effect of various flavonoids, including flavone, flavanone and isoflavone, on the human placental aromatase and 17beta-hydroxysteroid dehydrogenase was studied.	Flavonoids	52-62	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	146-181
9929167-4	1998	Flavonoids were shown to be potent inhibitors of both aromatase and 17beta-hydroxysteroid dehydrogenase activities.	Flavonoids	0-10	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	54-63
9929167-4	1998	Flavonoids were shown to be potent inhibitors of both aromatase and 17beta-hydroxysteroid dehydrogenase activities.	Flavonoids	0-10	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	68-103
9929167-7	1998	However, flavonoids with 7-methoxy or 8-hydroxyl groups on the A ring showed only anti-aromatase activity.	Flavonoids	9-19	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	87-96
9925284-1	1998	Inhibition of the tyrosine kinase activity of Src by forty-three different compounds from five chemical families (cinnamic acid, salicylic acid, phenol, coumarin and flavonoid derivatives) representing plant and microbial secondary metabolites were studied in the presence of MgCl2 versus MnCl2.	Flavonoids	166-175	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	46-49
9815107-1	1998	The ability of the flavonoids genistein, apigenin, kaempferol, and quercetin to activate cystic fibrosis transmembrane conductance regulator-mediated Cl currents in human airway epithelium was investigated.	Flavonoids	19-29	CF transmembrane conductance regulator	Homo sapiens	89-140
9793838-1	1998	Flavonoids and other benzopyrone substances, having an appropriate hydroxylation profile, may inhibit the metalloenzymes leucine aminopeptidase (LAP), aminopeptidase M (AP-M), and carboxypeptidase A (CP-A).	Flavonoids	0-10	LAP	Homo sapiens	121-143
9770503-10	1998	The f3h and fls null mutants complete the set of A. thaliana lines defective in early steps of the flavonoid pathway.	Flavonoids	99-108	flavanone 3-hydroxylase	Arabidopsis thaliana	4-7
9770503-10	1998	The f3h and fls null mutants complete the set of A. thaliana lines defective in early steps of the flavonoid pathway.	Flavonoids	99-108	flavonol synthase 1	Arabidopsis thaliana	12-15
9767651-1	1998	Previous studies have shown that flavonoids are modulators of the transmembrane P-glycoprotein (P-gp) which mediates cell multidrug resistance.	Flavonoids	33-43	ATP binding cassette subfamily B member 1	Homo sapiens	80-94
9767651-1	1998	Previous studies have shown that flavonoids are modulators of the transmembrane P-glycoprotein (P-gp) which mediates cell multidrug resistance.	Flavonoids	33-43	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
9705221-4	1998	Transiently expressed human UGT1A8 shows glucuronidation activities with coumarins, anthraquinones, flavonoids, phenolic compounds, catechol estrogens, 17-hydroxyandrogens, primary amines such as the carcinogen 4-aminobiphenyl, and certain opioids.	Flavonoids	100-110	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	28-34
9751276-7	1998	However, it seems that flavonoids at high concentrations exert their antiproliferative activity through other estrogen receptor-independent mechanisms.	Flavonoids	23-33	estrogen receptor 1	Homo sapiens	110-127
9734712-0	1998	Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines.	Flavonoids	20-30	crystallin, zeta	Mus musculus	77-94
9734712-1	1998	The ability of flavonoid compounds to induce the activity of the phase II anticarcinogenic marker enzyme, quinone reductase (QR), has been studied in a wild-type murine hepatoma cell line (Hepalclc7) and in an Ah-receptor-defective mutant of the same cell line (Hepalclc7 bp(r)cl).	Flavonoids	15-24	crystallin, zeta	Mus musculus	106-123
9734712-1	1998	The ability of flavonoid compounds to induce the activity of the phase II anticarcinogenic marker enzyme, quinone reductase (QR), has been studied in a wild-type murine hepatoma cell line (Hepalclc7) and in an Ah-receptor-defective mutant of the same cell line (Hepalclc7 bp(r)cl).	Flavonoids	15-24	crystallin, zeta	Mus musculus	125-127
9793838-1	1998	Flavonoids and other benzopyrone substances, having an appropriate hydroxylation profile, may inhibit the metalloenzymes leucine aminopeptidase (LAP), aminopeptidase M (AP-M), and carboxypeptidase A (CP-A).	Flavonoids	0-10	LAP	Homo sapiens	145-148
9793838-1	1998	Flavonoids and other benzopyrone substances, having an appropriate hydroxylation profile, may inhibit the metalloenzymes leucine aminopeptidase (LAP), aminopeptidase M (AP-M), and carboxypeptidase A (CP-A).	Flavonoids	0-10	alanyl aminopeptidase, membrane	Homo sapiens	151-167
9793838-1	1998	Flavonoids and other benzopyrone substances, having an appropriate hydroxylation profile, may inhibit the metalloenzymes leucine aminopeptidase (LAP), aminopeptidase M (AP-M), and carboxypeptidase A (CP-A).	Flavonoids	0-10	alanyl aminopeptidase, membrane	Homo sapiens	169-173
9793838-1	1998	Flavonoids and other benzopyrone substances, having an appropriate hydroxylation profile, may inhibit the metalloenzymes leucine aminopeptidase (LAP), aminopeptidase M (AP-M), and carboxypeptidase A (CP-A).	Flavonoids	0-10	carboxypeptidase A1	Homo sapiens	180-198
9793838-1	1998	Flavonoids and other benzopyrone substances, having an appropriate hydroxylation profile, may inhibit the metalloenzymes leucine aminopeptidase (LAP), aminopeptidase M (AP-M), and carboxypeptidase A (CP-A).	Flavonoids	0-10	carboxypeptidase A1	Homo sapiens	200-204
9793838-4	1998	The inhibitory effect of flavonoids on LAP was reversible, and to be effective the flavonoid had to have conjugated A and B rings and ortho-dihydroxylation on at least one of the aromatic rings.	Flavonoids	25-35	LAP	Homo sapiens	39-42
9793838-4	1998	The inhibitory effect of flavonoids on LAP was reversible, and to be effective the flavonoid had to have conjugated A and B rings and ortho-dihydroxylation on at least one of the aromatic rings.	Flavonoids	25-34	LAP	Homo sapiens	39-42
9793838-6	1998	The inhibitory effects on AP-M were due to inactivation of the enzyme, irreversibly altered by flavonoids with a 2,3-double bond and a minimum of one hydroxyl substituent on each of the aromatic rings.	Flavonoids	95-105	alanyl aminopeptidase, membrane	Homo sapiens	26-30
9793838-7	1998	With CP-A, conjugation of the A and B rings enhanced the inhibitory effect of flavonoids, though it was not strictly required.	Flavonoids	78-88	carboxypeptidase A1	Homo sapiens	5-9
9625730-2	1998	Among 23 flavonoids investigated, 8 were found to markedly stimulate the transcriptional activity of the human estrogen receptor in the yeast assay increasing transcriptional activity 5-13-fold above background level, corresponding to EC50 values between 0.1 and 25 microM.	Flavonoids	9-19	estrogen receptor 1	Homo sapiens	111-128
9622078-3	1998	Because dietary factors, such as flavonoids in soy products, may reduce the risk for hormone-dependent cancers, we studied the effects of flavonoids on testosterone-UDPGT activity.	Flavonoids	138-148	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	165-170
9642119-0	1998	Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression.	Flavonoids	41-50	ret proto-oncogene	Homo sapiens	104-128
9616184-7	1998	In addition to amines, expressed human UGT1A3 catalyzed the glucuronidation of opioids (e.g. morphine and buprenorphine), coumarins, flavonoids (e.g. naringenin and quercetin), anthraquinones, and small phenolic compounds (e.g. 4-nitrophenol).	Flavonoids	133-143	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	39-45
10076527-9	1998	The calculated inhibitory effect of flavonoids on CYP1A2 activity was highly correlated with the antimutagenicity of flavonoids in 2-amino-3,4-dimethylimidazo[4,5-flquinoline (MelQ)-induced umu response.	Flavonoids	36-46	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
10076527-9	1998	The calculated inhibitory effect of flavonoids on CYP1A2 activity was highly correlated with the antimutagenicity of flavonoids in 2-amino-3,4-dimethylimidazo[4,5-flquinoline (MelQ)-induced umu response.	Flavonoids	117-127	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
9648229-6	1998	The inhibitory effect of the flavonoids on the metabolic activation of Trp-P-2 to N-hydroxy-Trp-P-2 was almost in parallel with the antimutagenic IC50 value, when determined with a Saccharomyces cerevisiae AH22 cell simultaneously expressing both rat cytochrome P450 1A1 and yeast reductase.	Flavonoids	29-39	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	251-270
9495809-1	1998	PD98059 [2-(2"-amino-3"-methoxyphenyl)-oxanaphthalen-4-one] is a flavonoid and a potent inhibitor of mitogen-activated protein kinase kinase (MEK).	Flavonoids	65-74	mitogen-activated protein kinase kinase 7	Homo sapiens	142-145
9581834-0	1998	A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells.	Flavonoids	2-11	epidermal growth factor receptor	Homo sapiens	59-64
9563902-0	1998	Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins.	Flavonoids	29-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	155-158
9617795-3	1998	Here we describe the relationship between developmental and environmental regulation of flavonoid biosynthesis by examining phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase (DFR) mRNA levels in germinating Arabidopsis seedlings as a function of light, developmental stage and temperature.	Flavonoids	88-97	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	184-202
9617795-3	1998	Here we describe the relationship between developmental and environmental regulation of flavonoid biosynthesis by examining phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase (DFR) mRNA levels in germinating Arabidopsis seedlings as a function of light, developmental stage and temperature.	Flavonoids	88-97	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	204-207
9617795-3	1998	Here we describe the relationship between developmental and environmental regulation of flavonoid biosynthesis by examining phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase (DFR) mRNA levels in germinating Arabidopsis seedlings as a function of light, developmental stage and temperature.	Flavonoids	88-97	dihydroflavonol 4-reductase	Arabidopsis thaliana	214-239
9617795-3	1998	Here we describe the relationship between developmental and environmental regulation of flavonoid biosynthesis by examining phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase (DFR) mRNA levels in germinating Arabidopsis seedlings as a function of light, developmental stage and temperature.	Flavonoids	88-97	dihydroflavonol 4-reductase	Arabidopsis thaliana	241-244
9563902-0	1998	Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins.	Flavonoids	29-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-154
9480906-5	1998	or with a flavonoid, naringin, were completely or partly protective respectively against the OA-mediated suppression of CYP2B10 mRNA.	Flavonoids	10-19	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	120-127
9492341-2	1998	Studies of the hormone-like actions of bioflavonoids often use fetal or neonatal rats, which contain high levels of serum alpha-fetoprotein (AFP), a protein that binds estradiol with a Kd approximately 5 x 10(-9) M. Interaction of bioflavonoids with AFP could affect the availability of estrogens to estrogen-responsive cells, as well as the actions of bioflavonoids.	Flavonoids	231-244	alpha-fetoprotein	Rattus norvegicus	122-139
9492341-0	1998	Flavonoids inhibit estrogen binding to rat alpha-fetoprotein.	Flavonoids	0-10	alpha-fetoprotein	Rattus norvegicus	43-60
9492341-2	1998	Studies of the hormone-like actions of bioflavonoids often use fetal or neonatal rats, which contain high levels of serum alpha-fetoprotein (AFP), a protein that binds estradiol with a Kd approximately 5 x 10(-9) M. Interaction of bioflavonoids with AFP could affect the availability of estrogens to estrogen-responsive cells, as well as the actions of bioflavonoids.	Flavonoids	231-244	alpha-fetoprotein	Rattus norvegicus	141-144
9492341-2	1998	Studies of the hormone-like actions of bioflavonoids often use fetal or neonatal rats, which contain high levels of serum alpha-fetoprotein (AFP), a protein that binds estradiol with a Kd approximately 5 x 10(-9) M. Interaction of bioflavonoids with AFP could affect the availability of estrogens to estrogen-responsive cells, as well as the actions of bioflavonoids.	Flavonoids	39-52	alpha-fetoprotein	Rattus norvegicus	122-139
9492341-5	1998	This 10-fold [correction of 1Q-fold] difference in affinity for AFP between flavonoids and isoflavonoids suggests that AFP has a specificity for the flavonoid structure.	Flavonoids	76-86	alpha-fetoprotein	Rattus norvegicus	64-67
9492341-2	1998	Studies of the hormone-like actions of bioflavonoids often use fetal or neonatal rats, which contain high levels of serum alpha-fetoprotein (AFP), a protein that binds estradiol with a Kd approximately 5 x 10(-9) M. Interaction of bioflavonoids with AFP could affect the availability of estrogens to estrogen-responsive cells, as well as the actions of bioflavonoids.	Flavonoids	39-52	alpha-fetoprotein	Rattus norvegicus	141-144
9492341-2	1998	Studies of the hormone-like actions of bioflavonoids often use fetal or neonatal rats, which contain high levels of serum alpha-fetoprotein (AFP), a protein that binds estradiol with a Kd approximately 5 x 10(-9) M. Interaction of bioflavonoids with AFP could affect the availability of estrogens to estrogen-responsive cells, as well as the actions of bioflavonoids.	Flavonoids	231-244	alpha-fetoprotein	Rattus norvegicus	122-139
9492341-2	1998	Studies of the hormone-like actions of bioflavonoids often use fetal or neonatal rats, which contain high levels of serum alpha-fetoprotein (AFP), a protein that binds estradiol with a Kd approximately 5 x 10(-9) M. Interaction of bioflavonoids with AFP could affect the availability of estrogens to estrogen-responsive cells, as well as the actions of bioflavonoids.	Flavonoids	231-244	alpha-fetoprotein	Rattus norvegicus	141-144
9492341-5	1998	This 10-fold [correction of 1Q-fold] difference in affinity for AFP between flavonoids and isoflavonoids suggests that AFP has a specificity for the flavonoid structure.	Flavonoids	76-86	alpha-fetoprotein	Rattus norvegicus	119-122
9492341-5	1998	This 10-fold [correction of 1Q-fold] difference in affinity for AFP between flavonoids and isoflavonoids suggests that AFP has a specificity for the flavonoid structure.	Flavonoids	76-85	alpha-fetoprotein	Rattus norvegicus	64-67
9492341-5	1998	This 10-fold [correction of 1Q-fold] difference in affinity for AFP between flavonoids and isoflavonoids suggests that AFP has a specificity for the flavonoid structure.	Flavonoids	76-85	alpha-fetoprotein	Rattus norvegicus	119-122
9492341-6	1998	Moreover, the affinities of bioflavonoids for rat AFP are sufficiently high to suggest that flavonoids and isoflavonoids could modulate estradiol and estrone binding to rat AFP in vivo, when present at dietary levels.	Flavonoids	28-41	alpha-fetoprotein	Rattus norvegicus	50-53
9492341-6	1998	Moreover, the affinities of bioflavonoids for rat AFP are sufficiently high to suggest that flavonoids and isoflavonoids could modulate estradiol and estrone binding to rat AFP in vivo, when present at dietary levels.	Flavonoids	28-41	alpha-fetoprotein	Rattus norvegicus	173-176
9492341-6	1998	Moreover, the affinities of bioflavonoids for rat AFP are sufficiently high to suggest that flavonoids and isoflavonoids could modulate estradiol and estrone binding to rat AFP in vivo, when present at dietary levels.	Flavonoids	31-41	alpha-fetoprotein	Rattus norvegicus	50-53
9492341-6	1998	Moreover, the affinities of bioflavonoids for rat AFP are sufficiently high to suggest that flavonoids and isoflavonoids could modulate estradiol and estrone binding to rat AFP in vivo, when present at dietary levels.	Flavonoids	31-41	alpha-fetoprotein	Rattus norvegicus	173-176
9492341-8	1998	The flavonoids that we tested have different hydroxyl and glucoside substituents on the A, B, and C rings, which allows us to define some of the spatial requirements for binding to AFP.	Flavonoids	4-14	alpha-fetoprotein	Rattus norvegicus	181-184
9492341-10	1998	This information, combined with molecular modeling studies, may elucidate the molecular basis for recognition of flavonoids and estrogens by AFP.	Flavonoids	113-123	alpha-fetoprotein	Rattus norvegicus	141-144
9928474-3	1998	The plant signals, flavonoids exuded by the roots, activate the expression of nodulation genes, resulting in the production of the rhizobial lipochitooligosaccharide signals (Nod factors).	Flavonoids	19-29	atrophin 1	Homo sapiens	175-178
10682619-1	1998	The scavenging effects of total flavonoids of Lycium barbarum L. (TFL) were studied by using ESR-spin trapping technique and the inhibitory effects on heat output of both polymorphonuclear leukocyte(PMN) respiration burst and L1210 cells were measured by using microcalorimetric technique.	Flavonoids	32-42	zinc finger CCCH type containing 12D	Mus musculus	66-69
9486155-1	1998	The synthetic flavonoid EMD-49209 is a potent inhibitor of the in vivo and in vitro binding of thyroxine (T4) to transthyretin (TTR).	Flavonoids	14-23	transthyretin	Rattus norvegicus	128-131
9486155-8	1998	Because TTR concentrations are high in the fetal rat, especially in the brain, the transfer of flavonoid to the fetal brain might be linked to TTR expression.	Flavonoids	95-104	transthyretin	Rattus norvegicus	8-11
9486155-8	1998	Because TTR concentrations are high in the fetal rat, especially in the brain, the transfer of flavonoid to the fetal brain might be linked to TTR expression.	Flavonoids	95-104	transthyretin	Rattus norvegicus	143-146
9781303-7	1998	Certain flavonoids possess potent inhibitory activity against a wide array of enzymes, but of particular note is their inhibitory effects on several enzyme systems intimately connected to cell activation processes such as protein kinase C, protein tyrosine kinases, phospholipase A2, and others.	Flavonoids	8-18	phospholipase A2 group IB	Homo sapiens	266-282
9718089-6	1998	The results suggest that flavonoids may modulate pharmacological and toxicological effects mediated by CYP1A2.	Flavonoids	25-35	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	103-109
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Flavonoids	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
9461039-0	1997	Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids.	Flavonoids	105-115	crystallin, zeta	Mus musculus	49-66
9461039-2	1997	We have determined the structural requirements for this activity by examining the ability of naturally-occurring flavonoids to induce the phase II enzyme, quinone reductase (NAD(P)H:quinone oxidoreductase; EC 1.6.99.2), in murine Hepalclc7 cells.	Flavonoids	113-123	crystallin, zeta	Mus musculus	155-172
9461039-7	1997	The data show that, of the flavonoids, the flavonols are the most effective inducers of quinone reductase activity in Hepa1c1c7 cells (kaempferol approximately galangin &gt; quercetin &gt; myricetin approximately apigenin (a flavone)) and that flavanols and flavans are ineffective.	Flavonoids	27-37	crystallin, zeta	Mus musculus	88-105
9374426-5	1997	Analysis of structure-activity relationships showed certain chemical structures to be important for the inhibition of GSH-RD: (a) C-5 and C-7 hydroxylations in the A-ring, a carbonyl group at C-4, and the B-ring attached to C-2 in flavonoids; (b) C-2" and C-4" hydroxylations in chalcones; and (c) C-6 and C-7 hydroxylations in coumarins.	Flavonoids	231-241	complement C7	Homo sapiens	138-141
9345320-0	1997	Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNF alpha.	Flavonoids	42-51	tumor necrosis factor	Mus musculus	137-146
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Flavonoids	13-25	C-C motif chemokine ligand 2	Homo sapiens	71-105
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Flavonoids	13-25	tumor necrosis factor	Homo sapiens	120-147
9292787-3	1997	Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in cultured human synovial cells.	Flavonoids	156-168	tumor necrosis factor	Mus musculus	184-193
9292787-3	1997	Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in cultured human synovial cells.	Flavonoids	156-168	chemokine (C-X-C motif) ligand 15	Mus musculus	216-229
9292787-3	1997	Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in cultured human synovial cells.	Flavonoids	156-168	chemokine (C-X-C motif) ligand 15	Mus musculus	231-235
9449200-0	1997	Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids.	Flavonoids	81-91	steroid sulfatase	Homo sapiens	14-31
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 &lt; 10 microM for the most potent, quercetin.	Flavonoids	12-22	steroid sulfatase	Homo sapiens	87-104
9300039-11	1997	Moreover the enzyme was found to be highly resistant to heparin, a potent inhibitor of casein kinase II (CK II) and also resistant to CK I-7, a synthetic inhibitor of CK I, but very sensitive to a bioflavonoid quercetin.	Flavonoids	197-209	casein kinase 2 alpha 1	Homo sapiens	87-103
9379919-2	1997	The presence of an external metabolizing system, such as rat liver homogenates (S9 mix), leads to an increase in its genotoxicity, which is attributed to its biotransformation to the more genotoxic flavonoid quercetin, via the cytochrome P450 (CYP) mono-oxygenase system.	Flavonoids	198-207	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	227-242
9379919-2	1997	The presence of an external metabolizing system, such as rat liver homogenates (S9 mix), leads to an increase in its genotoxicity, which is attributed to its biotransformation to the more genotoxic flavonoid quercetin, via the cytochrome P450 (CYP) mono-oxygenase system.	Flavonoids	198-207	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	244-247
9379919-4	1997	Special attention has been given to the role of CYP in the genotoxicity of this flavonoid.	Flavonoids	80-89	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	48-51
9280310-5	1997	The present data are consistent with the hypothesis that certain (iso)flavonoids affect MRP-mediated transport of anticancer drugs by a direct interaction with MRP.	Flavonoids	70-80	ATP binding cassette subfamily C member 1	Homo sapiens	160-163
9280310-5	1997	The present data are consistent with the hypothesis that certain (iso)flavonoids affect MRP-mediated transport of anticancer drugs by a direct interaction with MRP.	Flavonoids	70-80	ATP binding cassette subfamily C member 1	Homo sapiens	88-91
9300039-11	1997	Moreover the enzyme was found to be highly resistant to heparin, a potent inhibitor of casein kinase II (CK II) and also resistant to CK I-7, a synthetic inhibitor of CK I, but very sensitive to a bioflavonoid quercetin.	Flavonoids	197-209	casein kinase 2 alpha 1	Homo sapiens	105-110
9300039-11	1997	Moreover the enzyme was found to be highly resistant to heparin, a potent inhibitor of casein kinase II (CK II) and also resistant to CK I-7, a synthetic inhibitor of CK I, but very sensitive to a bioflavonoid quercetin.	Flavonoids	197-209	choline kinase alpha	Homo sapiens	105-109
9287415-0	1997	Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells.	Flavonoids	0-10	tumor necrosis factor	Mus musculus	61-88
9287415-1	1997	The effects of some selected flavonoids on tumor necrosis factor-alpha (TNF)-induced cytotoxicity in murine fibroblast L-929 cells were studied.	Flavonoids	29-39	tumor necrosis factor	Mus musculus	43-70
9287415-1	1997	The effects of some selected flavonoids on tumor necrosis factor-alpha (TNF)-induced cytotoxicity in murine fibroblast L-929 cells were studied.	Flavonoids	29-39	tumor necrosis factor	Mus musculus	72-75
9287415-5	1997	The magnitude of protection and potentiation by these flavonoids were concentration-dependent and these effects were not altered when the flavonoids were added as much as 2 h after TNF treatment.	Flavonoids	54-64	tumor necrosis factor	Mus musculus	181-184
9214730-1	1997	Studies on the effects of flavonoids isolated from the roots of Scutellaria baicalensis on the fibrinolytic system induced by trypsin in cultured human umbilical vein endothelial cells (HUVECs) showed that baicalein (1) strongly inhibited the reduction of t-PA production and the elevation of PAI-1 production induced by trypsin.	Flavonoids	26-36	plasminogen activator, tissue type	Homo sapiens	256-260
9379363-0	1997	Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells.	Flavonoids	11-21	coagulation factor II, thrombin	Homo sapiens	159-167
9379363-0	1997	Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells.	Flavonoids	11-21	coagulation factor II, thrombin	Homo sapiens	172-180
9264317-6	1997	At elevated doses, some of these flavonoids were found to also cause significant inhibition of PKC and tyrosine kinase activity of EGF-R.	Flavonoids	33-43	epidermal growth factor receptor	Bos taurus	131-136
9246576-0	1997	Flavonoids as phospholipase A2 inhibitors: importance of their structure for selective inhibition of group II phospholipase A2.	Flavonoids	0-10	phospholipase A2 group IB	Homo sapiens	14-30
9246576-0	1997	Flavonoids as phospholipase A2 inhibitors: importance of their structure for selective inhibition of group II phospholipase A2.	Flavonoids	0-10	phospholipase A2 group IB	Homo sapiens	110-126
9246576-1	1997	The inhibitory effect of the plant flavonoid, rutin, on group I phospholipase A2 (PLA2-I) from porcine pancreas and Naja naja, and on group II phospholipase A2 (PLA2-II) from Vipera russelli and Crotalus atrox was investigated.	Flavonoids	35-44	phospholipase A2 group IB	Homo sapiens	64-80
9246576-1	1997	The inhibitory effect of the plant flavonoid, rutin, on group I phospholipase A2 (PLA2-I) from porcine pancreas and Naja naja, and on group II phospholipase A2 (PLA2-II) from Vipera russelli and Crotalus atrox was investigated.	Flavonoids	35-44	phospholipase A2 group IIA	Homo sapiens	82-86
9234165-1	1997	We examined the effects of nine flavonoids isolated from Scutellariae radix on interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression in cultured human umbilical vein endothelial cells (HUVECs).	Flavonoids	32-42	interleukin 1 beta	Homo sapiens	79-97
9234165-1	1997	We examined the effects of nine flavonoids isolated from Scutellariae radix on interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression in cultured human umbilical vein endothelial cells (HUVECs).	Flavonoids	32-42	interleukin 1 beta	Homo sapiens	99-108
9234165-1	1997	We examined the effects of nine flavonoids isolated from Scutellariae radix on interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression in cultured human umbilical vein endothelial cells (HUVECs).	Flavonoids	32-42	tumor necrosis factor	Homo sapiens	115-142
9234165-1	1997	We examined the effects of nine flavonoids isolated from Scutellariae radix on interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression in cultured human umbilical vein endothelial cells (HUVECs).	Flavonoids	32-42	tumor necrosis factor	Homo sapiens	144-153
9214730-1	1997	Studies on the effects of flavonoids isolated from the roots of Scutellaria baicalensis on the fibrinolytic system induced by trypsin in cultured human umbilical vein endothelial cells (HUVECs) showed that baicalein (1) strongly inhibited the reduction of t-PA production and the elevation of PAI-1 production induced by trypsin.	Flavonoids	26-36	serpin family E member 1	Homo sapiens	293-298
9202751-3	1997	In the presence of flavonoids such as alpha-naphthoflavone and flavone, both CYP3A4 and CYP3A5 have also been shown to play a minor role in the activation of food-derived heterocyclic amines.	Flavonoids	19-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
9218762-5	1997	We identified a flavonoid-inducible locus on the symbiotic plasmid pNGR234a that contains a new nodulation gene, noeE, which is required for the sulphation of NGR234 Nod factors (NodNGR).	Flavonoids	16-25	nodulation protein NoeE	Sinorhizobium fredii NGR234	113-117
9202751-3	1997	In the presence of flavonoids such as alpha-naphthoflavone and flavone, both CYP3A4 and CYP3A5 have also been shown to play a minor role in the activation of food-derived heterocyclic amines.	Flavonoids	19-29	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	88-94
9332170-6	1997	The flavonoids also offered strong inhibition of UDP-glucose dehydrogenase (UDP-GDH) activity in the liver cytosolic fraction while the activity in hepatocytes was not affected even after 4 hr of incubation.	Flavonoids	4-14	UDP-glucose 6-dehydrogenase	Rattus norvegicus	49-74
9112784-2	1997	As part of an ongoing investigation into the organization and regulation of the flavonoid biosynthetic pathway, two Arabidopsis thaliana expressed sequence tag (EST) clones (153O10T7 and YAY780) with high homology to leucoanthocyanidin dioxygenase (LDOX) or flavonol synthase (FLS) were identified.	Flavonoids	80-89	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	217-247
9112784-2	1997	As part of an ongoing investigation into the organization and regulation of the flavonoid biosynthetic pathway, two Arabidopsis thaliana expressed sequence tag (EST) clones (153O10T7 and YAY780) with high homology to leucoanthocyanidin dioxygenase (LDOX) or flavonol synthase (FLS) were identified.	Flavonoids	80-89	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	249-253
9112784-2	1997	As part of an ongoing investigation into the organization and regulation of the flavonoid biosynthetic pathway, two Arabidopsis thaliana expressed sequence tag (EST) clones (153O10T7 and YAY780) with high homology to leucoanthocyanidin dioxygenase (LDOX) or flavonol synthase (FLS) were identified.	Flavonoids	80-89	flavonol synthase 1	Arabidopsis thaliana	258-275
9112784-2	1997	As part of an ongoing investigation into the organization and regulation of the flavonoid biosynthetic pathway, two Arabidopsis thaliana expressed sequence tag (EST) clones (153O10T7 and YAY780) with high homology to leucoanthocyanidin dioxygenase (LDOX) or flavonol synthase (FLS) were identified.	Flavonoids	80-89	flavonol synthase 1	Arabidopsis thaliana	277-280
9112784-7	1997	These studies indicate that FLS is an "early" flavonoid gene in Arabidopsis seedlings, whereas LDOX is a "late" gene.	Flavonoids	46-55	flavonol synthase 1	Arabidopsis thaliana	28-31
9112784-8	1997	Furthermore, FLS is the first flavonoid enzyme identified in Arabidopsis that may be encoded by a gene family.	Flavonoids	30-39	flavonol synthase 1	Arabidopsis thaliana	13-16
9239522-12	1997	Flavonoids inhibited the expression of HSP27, HSP47, HSP60 and HSP72/73.	Flavonoids	0-10	heat shock protein family B (small) member 1	Homo sapiens	39-44
9239522-12	1997	Flavonoids inhibited the expression of HSP27, HSP47, HSP60 and HSP72/73.	Flavonoids	0-10	serpin family H member 1	Homo sapiens	46-51
9239522-12	1997	Flavonoids inhibited the expression of HSP27, HSP47, HSP60 and HSP72/73.	Flavonoids	0-10	heat shock protein family D (Hsp60) member 1	Homo sapiens	53-58
9239522-12	1997	Flavonoids inhibited the expression of HSP27, HSP47, HSP60 and HSP72/73.	Flavonoids	0-10	heat shock protein family A (Hsp70) member 1A	Homo sapiens	63-68
9140228-5	1997	Among the main active chemicals of OGT, baicalein, a kind of flavonoid, decreased ACAT activity in a dose-dependent fashion from the level of 10(-6)M. These results strongly suggest that OGT reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT, and that baicalein may, in part, be responsible for ACAT inhibition.	Flavonoids	61-70	carboxylesterase 1	Homo sapiens	82-86
9140228-5	1997	Among the main active chemicals of OGT, baicalein, a kind of flavonoid, decreased ACAT activity in a dose-dependent fashion from the level of 10(-6)M. These results strongly suggest that OGT reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT, and that baicalein may, in part, be responsible for ACAT inhibition.	Flavonoids	61-70	carboxylesterase 1	Homo sapiens	266-270
9140228-5	1997	Among the main active chemicals of OGT, baicalein, a kind of flavonoid, decreased ACAT activity in a dose-dependent fashion from the level of 10(-6)M. These results strongly suggest that OGT reduces the cholesteryl ester formation in human hepatocytes by inhibiting ACAT, and that baicalein may, in part, be responsible for ACAT inhibition.	Flavonoids	61-70	carboxylesterase 1	Homo sapiens	266-270
9332170-6	1997	The flavonoids also offered strong inhibition of UDP-glucose dehydrogenase (UDP-GDH) activity in the liver cytosolic fraction while the activity in hepatocytes was not affected even after 4 hr of incubation.	Flavonoids	4-14	UDP-glucose 6-dehydrogenase	Rattus norvegicus	76-83
9332170-7	1997	Interestingly, the GalN- induced strong inhibition of UDP-GDH in isolated hepatocytes was completely abolished by flavonoids.	Flavonoids	114-124	UDP-glucose 6-dehydrogenase	Rattus norvegicus	54-61
9332170-14	1997	The flavonoid counteracted D-GalN-induced lowering of UDPGA presumably by relieving UDP-GDH of in vivo inhibition affected by GalN-metabolite.	Flavonoids	4-13	UDP-glucose 6-dehydrogenase	Rattus norvegicus	84-91
8960067-1	1997	It has been claimed that the flavonoid genistein could be used to distinguish multidrug-resistant tumors expressing the multidrug resistance-associated protein (MRP) from those expressing P-glycoprotein (Pgp).	Flavonoids	29-38	ATP binding cassette subfamily C member 3	Homo sapiens	120-159
9076994-0	1997	BANYULS, a novel negative regulator of flavonoid biosynthesis in the Arabidopsis seed coat.	Flavonoids	39-48	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	0-7
9076994-5	1997	The phenotype of the double mutant banyuls/ transparent testa confirmed the flavonoid nature of the pigments and enabled assignment of the regulatory TT (Transparent Testa) genes to two groups according to their epistatic relationship to ban.	Flavonoids	76-85	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	35-42
9076994-9	1997	These results suggest that BANYULS functions as a negative regulator of flavonoid biosynthesis that prevents accumulation of pigments in the seed coat during early embryogenesis in Arabidopsis.	Flavonoids	72-81	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	27-34
9066718-0	1997	Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen.	Flavonoids	93-103	estrogen receptor 1	Homo sapiens	31-48
9066718-2	1997	Representatives of several different classes of flavonoids were tested for their effects on the proliferation of an estrogen receptor-positive human breast cancer cell line, MCF-7.	Flavonoids	48-58	estrogen receptor 1	Homo sapiens	116-133
9066718-5	1997	The possibility that flavonoids may block cell proliferation by binding to the estrogen receptor was explored.	Flavonoids	21-31	estrogen receptor 1	Homo sapiens	79-96
8960067-1	1997	It has been claimed that the flavonoid genistein could be used to distinguish multidrug-resistant tumors expressing the multidrug resistance-associated protein (MRP) from those expressing P-glycoprotein (Pgp).	Flavonoids	29-38	ATP binding cassette subfamily C member 3	Homo sapiens	161-164
8960067-6	1997	The flavonoid also decreased photoaffinity labeling of Pgp by [3H]azidopine, a Pgp substrate.	Flavonoids	4-13	ATP binding cassette subfamily B member 1	Homo sapiens	55-58
8960067-6	1997	The flavonoid also decreased photoaffinity labeling of Pgp by [3H]azidopine, a Pgp substrate.	Flavonoids	4-13	ATP binding cassette subfamily B member 1	Homo sapiens	79-82
9241349-7	1997	First flavonoids secreted by the plant roots induce the transcription of bacterial genes involved in nodulation, the so-called nod genes.	Flavonoids	6-16	atrophin 1	Homo sapiens	101-104
9587488-1	1997	Silibinin (SDH) is a flavonoid with ascertained hepatoprotective effects, which have been partially attributed to its antioxidant properties.	Flavonoids	21-30	serine dehydratase	Homo sapiens	11-14
9066634-1	1997	Apigenin, a widely distributed plant flavonoid, was previously found to inhibit chemically induced ornithine decarboxylase (ODC) activity and skin tumor promotion.	Flavonoids	37-46	ornithine decarboxylase, structural 1	Mus musculus	99-122
9066634-1	1997	Apigenin, a widely distributed plant flavonoid, was previously found to inhibit chemically induced ornithine decarboxylase (ODC) activity and skin tumor promotion.	Flavonoids	37-46	ornithine decarboxylase, structural 1	Mus musculus	124-127
8895505-0	1996	Flavonoids activate wild-type p53.	Flavonoids	0-10	tumor protein p53	Homo sapiens	30-33
8977455-0	1996	Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid.	Flavonoids	115-124	vascular cell adhesion molecule 1	Homo sapiens	54-87
8977455-4	1996	A flavonoid, 2-(3-amino-phenyl)-8-methoxy-chromene-4-one (PD 098063), markedly inhibited TNF-induced VCAM-1 cell-surface expression in a concentration-dependent fashion with half-maximal inhibition at 19 mumol/L but had no effect on ICAM-1 expression.	Flavonoids	2-11	tumor necrosis factor	Homo sapiens	89-92
8977455-4	1996	A flavonoid, 2-(3-amino-phenyl)-8-methoxy-chromene-4-one (PD 098063), markedly inhibited TNF-induced VCAM-1 cell-surface expression in a concentration-dependent fashion with half-maximal inhibition at 19 mumol/L but had no effect on ICAM-1 expression.	Flavonoids	2-11	vascular cell adhesion molecule 1	Homo sapiens	101-107
8977455-4	1996	A flavonoid, 2-(3-amino-phenyl)-8-methoxy-chromene-4-one (PD 098063), markedly inhibited TNF-induced VCAM-1 cell-surface expression in a concentration-dependent fashion with half-maximal inhibition at 19 mumol/L but had no effect on ICAM-1 expression.	Flavonoids	2-11	intercellular adhesion molecule 1	Homo sapiens	233-239
8977455-5	1996	Another structurally distinct flavonoid, 2-phenyl-chromene-4-one, similarly selectively decreased VCAM-1 expression.	Flavonoids	30-39	vascular cell adhesion molecule 1	Homo sapiens	98-104
8951505-0	1996	Inhibition of lysoPAF acetyltransferase activity by flavonoids.	Flavonoids	52-62	lysophosphatidylcholine acyltransferase 1	Rattus norvegicus	14-39
9516086-9	1997	Isoflavones and some other flavonoids have weak affinity for the estrogen receptor.	Flavonoids	27-37	estrogen receptor 1	Homo sapiens	65-82
9171888-0	1996	Extraordinary stability of IgE-binding Parietaria pollen allergens in relation to chemically bound flavonoids.	Flavonoids	99-109	immunoglobulin heavy constant epsilon	Homo sapiens	27-30
9171888-7	1996	It is proposed that the extraordinary stability of IgE-binding Parietaria components over a wide molecular range may be attributed to chromophoric flavonoid side-chains as (parts of) the corresponding B-cell epitopes.	Flavonoids	147-156	immunoglobulin heavy constant epsilon	Homo sapiens	51-54
8895505-5	1996	We found that incubation of the non-tumour cell line C3H10T1/2CL8 with these flavonoids resulted in induction of p53 accumulation and apoptosis.	Flavonoids	77-87	tumor protein p53	Homo sapiens	113-116
8895505-8	1996	Differences between the flavonoids tested concerned p53 accumulation kinetics as well as the biological activity of accumulated p53 and might be due to different modes of flavonoid action.	Flavonoids	24-34	tumor protein p53	Homo sapiens	52-55
8895505-8	1996	Differences between the flavonoids tested concerned p53 accumulation kinetics as well as the biological activity of accumulated p53 and might be due to different modes of flavonoid action.	Flavonoids	24-33	tumor protein p53	Homo sapiens	52-55
8895505-9	1996	These data suggest that both aspects of flavonoid effects, i.e. inhibition of tumour growth through cell cycle arrest and induction of apoptosis, are functionally related to p53.	Flavonoids	40-49	tumor protein p53	Homo sapiens	174-177
8930885-1	1996	OBJECTIVE: Apigenin is a flavonoid that effectively blocks intercellular adhesion molecule-1 (ICAM-1) upregulation and leukocyte adhesion in response to cytokines in vitro.	Flavonoids	25-34	intercellular adhesion molecule 1	Rattus norvegicus	59-92
8947915-4	1996	While histidine ammonia-lyase catalyses the first step of histidine degradation in most cells, phenylalanine ammonia-lyase is an important plant enzyme, producing cinnamic acid which is the precursor of lignins, coumarins and flavonoids responsible for the marvelous colours of many flowers.	Flavonoids	226-236	histidine ammonia-lyase	Homo sapiens	6-29
8930885-1	1996	OBJECTIVE: Apigenin is a flavonoid that effectively blocks intercellular adhesion molecule-1 (ICAM-1) upregulation and leukocyte adhesion in response to cytokines in vitro.	Flavonoids	25-34	intercellular adhesion molecule 1	Rattus norvegicus	94-100
23194969-4	1996	All the flavonoids tested decreased the manifestation of SRBC induced delayed type hypersensitivity reaction and showed no effect on classical or alternative pathway dependent hemolysis.	Flavonoids	8-18	caveolae associated 3	Mus musculus	57-61
8806713-7	1996	It was found that both rat and human UGT1.1 exhibited comparable substrate specificities and efficiencies (Vmax/Km) of glucuronide formation for anthraquinones, coumarins, estrogens, flavonoids, and phenolic compounds.	Flavonoids	183-193	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
8665487-2	1996	The three flavonoids induced a concentration-dependent decrease of both the nuclear GSH content and GST activity.	Flavonoids	10-20	hematopoietic prostaglandin D synthase	Rattus norvegicus	100-103
8776895-1	1996	The recessive mutation intensifier1 of maize apparently causes an overall increase in flavonoid production in the aleurone.	Flavonoids	86-95	transcription factor BHLH42	Zea mays	23-35
8665487-0	1996	Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei.	Flavonoids	24-34	hematopoietic prostaglandin D synthase	Rattus norvegicus	63-88
8808829-31	1996	Several flavonoids were screened to have ability to suppress the secretion of MMPs.	Flavonoids	8-18	matrix metallopeptidase 2	Homo sapiens	78-82
8687487-1	1996	Lipid peroxidation in human LDL (0.05 mg protein/mL) incubated with Cu(2+)-ions (5 microM) in vitro was dose-dependently inhibited by the flavonoid myrigalone B (MyB) and by ascorbic acid.	Flavonoids	138-147	MYB proto-oncogene, transcription factor	Homo sapiens	162-165
8799468-2	1996	The present study investigated which step Gingko biloba extract (EGb 761), a flavonoid phytochemical rich preparation can affect signal transduction during AP-1 activation.	Flavonoids	77-86	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-160
8695910-3	1996	Microsomal lipid peroxidation induced by NADPH-cytochrome P-450 reductase was also inhibited by these flavonoids.	Flavonoids	102-112	cytochrome p450 oxidoreductase	Homo sapiens	41-73
8861287-7	1996	Antagonism of PKC by phloretin, a flavonoid which prevents PKC activation, and PKC depletion induced by a 24 h treatment with 10(-6)M PMA, completely inhibited the response to GHRP6.	Flavonoids	34-43	proline rich transmembrane protein 2	Homo sapiens	14-17
8704306-1	1996	The inhibitory effects of flavonoids on the activity of two photosynthetic enzymes such as phosphoenolpyruvate carboxylase (PEPCase) and NADP-dependent malic enzyme (NADP-ME) were evaluated.	Flavonoids	26-36	phosphoenolpyruvate carboxykinase 1	Homo sapiens	91-122
8704306-1	1996	The inhibitory effects of flavonoids on the activity of two photosynthetic enzymes such as phosphoenolpyruvate carboxylase (PEPCase) and NADP-dependent malic enzyme (NADP-ME) were evaluated.	Flavonoids	26-36	phosphoenolpyruvate carboxykinase 1	Homo sapiens	124-131
8704306-1	1996	The inhibitory effects of flavonoids on the activity of two photosynthetic enzymes such as phosphoenolpyruvate carboxylase (PEPCase) and NADP-dependent malic enzyme (NADP-ME) were evaluated.	Flavonoids	26-36	malic enzyme 1	Homo sapiens	137-164
8704306-1	1996	The inhibitory effects of flavonoids on the activity of two photosynthetic enzymes such as phosphoenolpyruvate carboxylase (PEPCase) and NADP-dependent malic enzyme (NADP-ME) were evaluated.	Flavonoids	26-36	malic enzyme 1	Homo sapiens	166-173
8610110-0	1996	Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.	Flavonoids	50-59	cyclin dependent kinase 2	Homo sapiens	79-83
8685272-7	1996	The F3H gene may represent a pivotal point in the regulation of flavonoid biosynthesis because its expression is coordinated with different subsets of genes in different plant species.	Flavonoids	64-73	flavanone 3-hydroxylase	Arabidopsis thaliana	4-7
8882428-1	1996	Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro.	Flavonoids	19-29	interleukin 1 beta	Homo sapiens	183-201
8548766-4	1996	Because quercetin was shown to modulate hsp70 expression after heat shock in K562 cells, we have investigated the effect of this flavonoid on HSF activation, hsp70 synthesis, and thermotolerance in human K562 cells after induction with PGA1.	Flavonoids	129-138	interleukin 6	Homo sapiens	142-145
8720382-0	1996	Inhibition of adenosine deaminase activity of aortic endothelial cells by selected flavonoids.	Flavonoids	83-93	adenosine deaminase	Homo sapiens	14-33
8720382-2	1996	These results support the suggestion that many pharmacological actions of flavonoids are mediated by an amplification of the effect of endogenous adenosine via adenosine receptors because adenosine deaminase is responsible for the adenosine inactivation.	Flavonoids	74-84	adenosine deaminase	Homo sapiens	188-207
8576124-3	1996	In this study, we examined the mechanism of inhibition by quercetin of the catechol O-methyltransferase-catalyzed O-methylation of catecholestrogens as a basis for the previously reported enhancement of estradiol-induced tumorigenesis by this flavonoid.	Flavonoids	243-252	catechol O-methyltransferase	Mesocricetus auratus	75-103
23194768-0	1996	Angiotensin converting enzyme (ACE) inhibitory flavonoids from Erythroxylum laurifolium.	Flavonoids	47-57	angiotensin I converting enzyme	Homo sapiens	0-29
23194768-0	1996	Angiotensin converting enzyme (ACE) inhibitory flavonoids from Erythroxylum laurifolium.	Flavonoids	47-57	angiotensin I converting enzyme	Homo sapiens	31-34
8825617-3	1996	By screening flavonoids from six different classes, three structurally related compounds (chrysin, acacetin, and apigenin) were identified that inhibited HIV expression in TNF-alpha-treated OM-10.1 cultures.	Flavonoids	13-23	tumor necrosis factor	Homo sapiens	172-181
8924586-0	1996	Inhibition of thyroid peroxidase by dietary flavonoids.	Flavonoids	44-54	thyroid peroxidase	Homo sapiens	14-32
8924586-2	1996	A structure-activity study of 13 commonly consumed flavonoids was conducted to evaluate inhibition of thyroid peroxidase (TPO), the enzyme that catalyzes thyroid hormone biosynthesis.	Flavonoids	51-61	thyroid peroxidase	Homo sapiens	102-120
8924586-2	1996	A structure-activity study of 13 commonly consumed flavonoids was conducted to evaluate inhibition of thyroid peroxidase (TPO), the enzyme that catalyzes thyroid hormone biosynthesis.	Flavonoids	51-61	thyroid peroxidase	Homo sapiens	122-125
8924586-3	1996	Most flavonoids tested were potent inhibitors of TPO, with IC50 values ranging from 0.6 to 41 microM.	Flavonoids	5-15	thyroid peroxidase	Homo sapiens	49-52
8924586-5	1996	Other flavonoids inhibited TPO by different mechanisms, such as myricetin and naringin, showed noncompetitive inhibition of tyrosine iodination with respect to iodine ion and linear mixed-type inhibition with respect to hydrogen peroxide.	Flavonoids	6-16	thyroid peroxidase	Homo sapiens	27-30
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Flavonoids	116-126	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Flavonoids	116-126	interleukin 6	Homo sapiens	69-82
8539286-3	1995	Despite its ability to accumulate UV-absorptive flavonoid compounds, the ferulic acid hydroxylase mutant fah1 exhibits more physiological injury (growth inhibition and foliar lesions) than either wild type or tt5.	Flavonoids	48-57	ferulic acid 5-hydroxylase 1	Arabidopsis thaliana	105-109
7483672-14	1995	Resorcinol and related dietary flavonoids are suicide substrates for TPO and act by covalent binding to amino acid residues, presumably those radical sites present in the compound I isomer.	Flavonoids	31-41	thyroid peroxidase	Homo sapiens	69-72
8572604-6	1995	The bioflavonoid, quercetin, a non-specific tyrosine protein kinase inhibitor, at a concentration of 30 microM completely abolished the action of interferon-gamma on thymidine incorporation.	Flavonoids	4-16	interferon gamma	Homo sapiens	146-162
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	RELA proto-oncogene, NF-kB subunit	Homo sapiens	103-107
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	tumor necrosis factor	Homo sapiens	146-155
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	galactosidase beta 1	Homo sapiens	164-182
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	galactosidase beta 1	Homo sapiens	233-251
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	nuclear factor kappa B subunit 1	Homo sapiens	286-296
7543732-6	1995	Although apigenin did not inhibit TNF-alpha-induced nuclear translocation of NF-kappa B(p50(NFKB1)/p65(RelA)) we found this flavonoid did inhibit TNF-alpha induced beta-galactosidase activity in SW480 cells stably transfected with a beta-galactosidase reporter construct driven by four NF-kappa B elements, suggesting an action on NF-kappa B transcriptional activation.	Flavonoids	124-133	nuclear factor kappa B subunit 1	Homo sapiens	286-296
7582506-0	1995	Inhibition by cromoglycate and some flavonoids of nucleoside diphosphate kinase and of exocytosis from permeabilized mast cells.	Flavonoids	36-46	cytidine/uridine monophosphate kinase 2	Homo sapiens	50-79
7635257-6	1995	These flavonoids produced an inhibition of soybean lipoxygenase activity in a dose-dependent manner, with IC50 values (20 and 29 microM respectively) similar to the reference drug.	Flavonoids	6-16	linoleate 9S-lipoxygenase-4	Glycine max	51-63
7616308-9	1995	The bathochromic properties of flavonoids in the presence of albumin are highly dependent on the presence of the C-2/C-3 double bond on the C-ring and are influenced by the degree of B-ring hydroxylation.	Flavonoids	31-41	complement C2	Rattus norvegicus	113-120
7675900-0	1995	[The effects of various flavonoids and phenolcarboxylic acids on adenosine deaminase in cultured endothelial cells].	Flavonoids	24-34	adenosine deaminase	Homo sapiens	65-84
8523269-0	1995	[Screening of phagocyte activators in plants; enhancement of TNF production by flavonoids].	Flavonoids	79-89	tumor necrosis factor	Mus musculus	61-64
8523269-3	1995	To prove the fact that plant foods contain substances which activate the host defense mechanisms, we first examined if the administration of flavonoids could induce TNF production in mice.	Flavonoids	141-151	tumor necrosis factor	Mus musculus	165-168
8523269-4	1995	Some selected flavonoids such as naringin, apiin, poncirin and rutin were shown to amplify TNF release from murine macrophages in vivo in response to OK-432 as a second stimulus.	Flavonoids	14-24	tumor necrosis factor	Mus musculus	91-94
8523269-6	1995	The differences in the saccharide-chain of flavonoids induced the variety of TNF production.	Flavonoids	43-53	tumor necrosis factor	Mus musculus	77-80
7476161-8	1995	Surprisingly, many genes remained transcribed in the nodD1- mutant suggesting the presence of other flavonoid-dependent activators in NGR234.	Flavonoids	100-109	transcriptional regulator NodD1	Sinorhizobium fredii NGR234	53-58
7673925-4	1995	Inhibition of leucine aminopeptidase by flavonoids does not require 5,7-hydroxylation, but dihydroxylation at C-3" and C-4" and a double bond at positions C-2, C-3 are essential for this activity.	Flavonoids	40-50	complement C3	Homo sapiens	160-163
7744816-7	1995	TNF alpha and bFGF induction of ROS production is mediated through flavonoid-containing enzymes such as NADPH oxidase.	Flavonoids	67-76	tumor necrosis factor	Homo sapiens	0-9
7744816-7	1995	TNF alpha and bFGF induction of ROS production is mediated through flavonoid-containing enzymes such as NADPH oxidase.	Flavonoids	67-76	fibroblast growth factor 2	Homo sapiens	14-18
8547814-0	1995	Extension-growth responses and expression of flavonoid biosynthesis genes in the Arabidopsis hy4 mutant.	Flavonoids	45-54	cryptochrome 1	Arabidopsis thaliana	93-96
7599308-1	1995	The expression of chalcone synthase (CHS) genes, which encode the first enzyme of the flavonoid pathway, is under developmental control as well as affected by external stimuli such as light.	Flavonoids	86-95	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	37-40
7773305-7	1995	Slot blot analysis showed that F3H transcript levels in young seedlings are increased by high fluence-rate white light treatment in the presence of the anthocyanin regulatory gene -r. HPLC analysis of extracts from developmentally staged anthers showed that flavonol accumulation begins at the uninucleate microspore stage, continues until maturity, and is not controlled by -r. When the expression pattern of several flavonoid biosynthetic genes was analyzed during microsporogenesis, only F3H transcript accumulation was coordinate with the appearance of flavonols in anthers.	Flavonoids	418-427	Flavanone 3-dioxygenase 1	Zea mays	31-34
7779146-1	1995	The purpose of the present study was to investigate the effects of the flavonoid delphinidin chloride (CAS 528-53-0, IdB 1056) on diabetic microangiopathy.	Flavonoids	71-80	BCAR1 scaffold protein, Cas family member	Homo sapiens	103-106
8820861-3	1995	The types of anthocyanins synthesised in plants are controlled by the cytochrome P450 enzymes flavonoid 3"-hydroxylase and flavonoid 3",5"-hydroxylase.	Flavonoids	94-103	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	81-85
7769390-3	1995	Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3", and C-4" positions and also required a keto group at C-4.	Flavonoids	0-10	complement C3	Homo sapiens	101-104
7769390-3	1995	Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3", and C-4" positions and also required a keto group at C-4.	Flavonoids	0-10	complement C7	Homo sapiens	106-109
7769390-3	1995	Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3", and C-4" positions and also required a keto group at C-4.	Flavonoids	0-10	complement C3	Homo sapiens	111-114
7769390-3	1995	Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3", and C-4" positions and also required a keto group at C-4.	Flavonoids	0-10	complement C4A (Rodgers blood group)	Homo sapiens	121-124
7769390-3	1995	Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3", and C-4" positions and also required a keto group at C-4.	Flavonoids	0-10	complement C4A (Rodgers blood group)	Homo sapiens	170-173
7870067-3	1995	Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta.	Flavonoids	9-18	interleukin 1 alpha	Mus musculus	71-81
7870067-3	1995	Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta.	Flavonoids	9-18	tumor necrosis factor	Mus musculus	98-107
8547814-5	1995	Anthocyanin formation and the expression of several flavonoid biosynthesis genes is stimulated by blue light in the wild type but to a much lower extent in hy4.	Flavonoids	52-61	cryptochrome 1	Arabidopsis thaliana	156-159
7892294-4	1995	Selected examples of estrogenic flavonoids were further analyzed to determine their biological potencies and their relative affinities for binding to the estrogen receptor.	Flavonoids	32-42	estrogen receptor 1	Homo sapiens	154-171
7945444-3	1994	To examine this possibility, a series of flavonoids commonly found in plant foods was tested for their ability to modulate [14C]Adriamycin ([14C]ADR) accumulation and efflux in P-gp-expressing HCT-15 colon cells.	Flavonoids	41-51	ATP binding cassette subfamily B member 1	Homo sapiens	177-181
8844805-7	1995	Members of the human CYP3A subfamily (CYP3A4 and CYP3A5) were capable of activating the heterocyclic amine, 2-amino-3,4-dimethylimadazo[4,5,f]quinoline (MeIQ), to a mutagen in the Ames test in the presence of the modulating flavonoid, alpha-napthoflavone.	Flavonoids	224-233	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-26
8844805-7	1995	Members of the human CYP3A subfamily (CYP3A4 and CYP3A5) were capable of activating the heterocyclic amine, 2-amino-3,4-dimethylimadazo[4,5,f]quinoline (MeIQ), to a mutagen in the Ames test in the presence of the modulating flavonoid, alpha-napthoflavone.	Flavonoids	224-233	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-44
8844805-7	1995	Members of the human CYP3A subfamily (CYP3A4 and CYP3A5) were capable of activating the heterocyclic amine, 2-amino-3,4-dimethylimadazo[4,5,f]quinoline (MeIQ), to a mutagen in the Ames test in the presence of the modulating flavonoid, alpha-napthoflavone.	Flavonoids	224-233	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	49-55
7827497-6	1994	The -98 to -88 region is more important for B/C1 transactivation and shows a strong homology with the region of the Bz1 anthocyanin structural gene promoter shown to be activated by B/C1 and not by P. We identified a 14-bp consensus sequence that is also present in the promoters of three other genes in the anthocyanin pathway, and we propose a model for how the flavonoid regulatory proteins interact with the promoters of the structural genes.	Flavonoids	364-373	anthocyanidin 3-O-glucosyltransferase	Zea mays	116-119
7945444-7	1994	The magnitude of flavonoid-stimulated efflux in sodium butyrate-treated cells with a 4-fold induction of P-gp protein was similar to that in uninduced cells.	Flavonoids	17-26	ATP binding cassette subfamily B member 1	Homo sapiens	105-109
7945444-11	1994	It is concluded that certain naturally occurring plant flavonoids may acutely upregulate the apparent activity of P-gp.	Flavonoids	55-65	ATP binding cassette subfamily B member 1	Homo sapiens	114-118
8010991-1	1994	Several novel naturally occurring flavonoids and other polyphenols exerted varying degrees of concentration-dependent inhibition on uncharacterized rat liver glutathione S-transferase (EC 2.5.1.18, GST) isoforms.	Flavonoids	34-44	hematopoietic prostaglandin D synthase	Rattus norvegicus	158-183
8002990-0	1994	Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.	Flavonoids	49-58	cyclin dependent kinase 1	Homo sapiens	21-25
8155716-2	1994	cDNA-expressed mouse CYP1A1 and CYP1A2 differed in their sensitivity to both hydroxylated and nonhydroxylated flavonoids, respectively.	Flavonoids	110-120	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	21-27
8198534-3	1994	Although many types of HSP70 inducers have been identified, only a few compounds, all belonging to the flavonoid group, have been shown to inhibit HSP70 induction.	Flavonoids	103-112	heat shock protein family A (Hsp70) member 4	Homo sapiens	147-152
8185313-5	1994	We also investigated the effect of various radical scavengers and antioxidants (glucose, vitamin E, dithiothreitol, flavonoids) which are able to influence the inactivation of hexokinase activity to different extents.	Flavonoids	116-126	hexokinase-2	Oryctolagus cuniculus	176-186
8155716-2	1994	cDNA-expressed mouse CYP1A1 and CYP1A2 differed in their sensitivity to both hydroxylated and nonhydroxylated flavonoids, respectively.	Flavonoids	110-120	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	32-38
8155716-4	1994	In contrast, hydroxylated flavonoids increased the 7-methoxyresorufin O-demethylation and acetanilide 4-hydroxylation activities of cDNA-expressed human CYP1A2 and in human liver microsomes.	Flavonoids	26-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	153-159
8190018-1	1994	Six flavonoid derivatives were tested for their influence on Naja naja and human recombinant synovial phospholipase A2.	Flavonoids	4-13	phospholipase A2 group IB	Homo sapiens	102-118
7718036-6	1994	In the first stage, flavonoids secreted by the plant root induce, in a host specific way, the transcription of bacterial genes which are involved in nodulation, the so-called nod genes.	Flavonoids	20-30	atrophin 1	Homo sapiens	149-152
8194125-1	1994	The involvement of the alcohol-inducible cytochrome P450 2E1 in the hepatoprotective mechanism of the plant flavonoid extract silymarin, and its main active component silybin, was investigated in isolated hepatocytes.	Flavonoids	108-117	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	41-60
8201941-0	1994	The structure-activity relationships of flavonoids as inhibitors of cytochrome P-450 enzymes in rat liver microsomes and the mutagenicity of 2-amino-3-methyl-imidazo[4,5-f]quinoline.	Flavonoids	40-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-84
7923555-3	1994	Since ADR resistance in these cells is associated with the expression of high levels of P-glycoprotein (Pgp), we evaluated the effect of Q and related flavonoids of Pgp activity in cytofluorographic efflux experiments with the fluorescent dye rhodamine 123 (Rh 123).	Flavonoids	151-161	ATP binding cassette subfamily B member 1	Homo sapiens	165-168
7905399-7	1993	A brief characterization of the in vitro glucuronidation of some flavonoid compounds using liver microsomal preparations suggests that this important class of natural compounds might be conjugated by a specific isoform of UDP-glucuronosyltransferase.	Flavonoids	65-74	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	222-249
7506028-3	1993	Here we show that the flavonoid quercetin, which inhibits mast cell secretion of histamine, also inhibited RBL cell proliferation and constitutive histamine release while it induced synthesis of rat mast cell protease (RMCP) II and triggered processes leading to accumulation of secretory granules.	Flavonoids	22-31	mast cell protease 2	Rattus norvegicus	204-227
1329770-0	1992	Inhibition of glutathione reductase by flavonoids.	Flavonoids	39-49	glutathione-disulfide reductase	Homo sapiens	14-35
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Flavonoids	42-52	ornithine decarboxylase, structural 1	Mus musculus	131-154
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Flavonoids	42-52	ornithine decarboxylase, structural 1	Mus musculus	156-159
8220481-2	1993	During vascular system and floral organ differentiation, the parsley 4CL-1 gene is expressed in a restricted set of tissues and cell types where 4CL activity is required to supply precursors for the synthesis of diverse phenylpropanoid-derived products such as lignin and flavonoids.	Flavonoids	272-282	4-coumarate--CoA ligase 1	Nicotiana tabacum	69-74
21573336-3	1993	The IC50 values for 2-hydroxy chalcone (the most potent flavonoid) and the cytotoxic drug colchicine, were 8 muM and &lt; 0.1 muM, respectively.	Flavonoids	56-65	latexin	Homo sapiens	109-112
21573336-3	1993	The IC50 values for 2-hydroxy chalcone (the most potent flavonoid) and the cytotoxic drug colchicine, were 8 muM and &lt; 0.1 muM, respectively.	Flavonoids	56-65	latexin	Homo sapiens	126-129
8341277-5	1993	Evidence is presented to show that selected hydroxylated flavonoids interact directly with the estrogen receptor, based on their ability to compete for the binding of 17 beta-[3H]estradiol to the receptor in cell-free extracts.	Flavonoids	57-67	estrogen receptor 1	Homo sapiens	95-112
8292974-1	1993	The in vitro effects of the bioflavonoid antioxidant silymarin on the expression and activity of superoxide dismutase (SOD) enzyme was studied in erythrocytes and lymphocytes from patients with chronic alcoholic liver disease.	Flavonoids	28-40	superoxide dismutase 1	Homo sapiens	97-117
8292974-1	1993	The in vitro effects of the bioflavonoid antioxidant silymarin on the expression and activity of superoxide dismutase (SOD) enzyme was studied in erythrocytes and lymphocytes from patients with chronic alcoholic liver disease.	Flavonoids	28-40	superoxide dismutase 1	Homo sapiens	119-122
1329770-12	1992	did not directly inhibit GR but reacted directly with certain flavonoids to form a reactive intermediate which, in turn, inhibited GR.	Flavonoids	62-72	glutathione-disulfide reductase	Homo sapiens	131-133
1329770-13	1992	These findings suggest that the mechanism of inhibition of GR by flavonoids is complex and may have oxygen-dependent and oxygen-independent components.	Flavonoids	65-75	glutathione-disulfide reductase	Homo sapiens	59-61
1329770-2	1992	A structure-activity study of fourteen chemically related flavonoids was conducted to evaluate their abilities to inhibit glutathione reductase (GR).	Flavonoids	58-68	glutathione-disulfide reductase	Homo sapiens	122-143
1329770-2	1992	A structure-activity study of fourteen chemically related flavonoids was conducted to evaluate their abilities to inhibit glutathione reductase (GR).	Flavonoids	58-68	glutathione-disulfide reductase	Homo sapiens	145-147
1329770-3	1992	By comparing the I50 values of flavonoids from different classes possessing an identical hydroxyl configuration, we determined the following order of potency for inhibition of GR: anthocyanidin &gt; dihydroflavonol = chalcone &gt; flavonol &gt; catechin.	Flavonoids	31-41	glutathione-disulfide reductase	Homo sapiens	176-178
1324726-1	1992	We report here that quercetin, a naturally occurring bioflavonoid, is an effective blocker of insulin receptor tyrosine kinase-catalyzed phosphorylation of exogenous substrate.	Flavonoids	53-65	insulin receptor	Mus musculus	94-110
12297632-2	1992	We observed that steady state levels of mRNAs encoded by four flavonoid biosynthetic genes, PAL1 (encoding phenylalanine ammonia-lyase 1), CHS (encoding chalcone synthase), CHI (encoding chalcone isomerase), and DFR (encoding dihydroflavonol reductase), were temporally regulated, peaking in 3-day-old seedlings grown in continuous white light.	Flavonoids	62-71	PHE ammonia lyase 1	Arabidopsis thaliana	107-136
12297632-2	1992	We observed that steady state levels of mRNAs encoded by four flavonoid biosynthetic genes, PAL1 (encoding phenylalanine ammonia-lyase 1), CHS (encoding chalcone synthase), CHI (encoding chalcone isomerase), and DFR (encoding dihydroflavonol reductase), were temporally regulated, peaking in 3-day-old seedlings grown in continuous white light.	Flavonoids	62-71	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	187-205
12297632-2	1992	We observed that steady state levels of mRNAs encoded by four flavonoid biosynthetic genes, PAL1 (encoding phenylalanine ammonia-lyase 1), CHS (encoding chalcone synthase), CHI (encoding chalcone isomerase), and DFR (encoding dihydroflavonol reductase), were temporally regulated, peaking in 3-day-old seedlings grown in continuous white light.	Flavonoids	62-71	dihydroflavonol 4-reductase	Arabidopsis thaliana	212-215
12297632-2	1992	We observed that steady state levels of mRNAs encoded by four flavonoid biosynthetic genes, PAL1 (encoding phenylalanine ammonia-lyase 1), CHS (encoding chalcone synthase), CHI (encoding chalcone isomerase), and DFR (encoding dihydroflavonol reductase), were temporally regulated, peaking in 3-day-old seedlings grown in continuous white light.	Flavonoids	62-71	dihydroflavonol 4-reductase	Arabidopsis thaliana	226-251
11607312-1	1992	Chalcone synthase catalyzes the initial step of that branch of the phenylpropanoid pathway that leads to flavonoids.	Flavonoids	105-115	chalcone synthase	Zea mays	0-17
1639455-2	1992	Agents that inhibit the lipoxygenase pathway such as phenidone and the flavonoid baicalein can selectively attenuate contractile responses to angiotensin II in vivo as well as in isolated vascular tissue.	Flavonoids	71-80	angiotensinogen	Rattus norvegicus	142-156
1321338-0	1992	Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids.	Flavonoids	74-84	interleukin 6	Homo sapiens	32-49
11607312-2	1992	A lack of chalcone synthase activity has a pleiotropic effect in maize and petunia mutants: pollen fertility as well as flavonoid synthesis is disrupted.	Flavonoids	120-129	chalcone synthase	Zea mays	10-27
1314077-7	1992	It is suggested that lignans and isoflavonoids may affect uptake and metabolism of sex hormones by participating in the regulation of plasma SHBG levels and in this way influence their biological activity and that they may inhibit cancer cell growth like some flavonoids by competing with estradiol for the type II estrogen binding sites.	Flavonoids	36-46	sex hormone binding globulin	Homo sapiens	141-145
1631168-1	1992	The crystal structure of the complex of 3",5"-dibromo-2",4,4",6-tetrahydroxyaurone, a flavone derivative, with human transthyretin (TTR), a serum thyroid hormone transport protein, has been determined and refined to R = 17.9% for data to 2.3-A resolution and provides a detailed description of a protein-bound flavonoid structure.	Flavonoids	310-319	transthyretin	Homo sapiens	117-130
1469950-0	1992	In vitro inhibition of adenosine deaminase by flavonoids and related compounds.	Flavonoids	46-56	adenosine deaminase	Homo sapiens	23-42
1469950-2	1992	The effects of 20 flavonoids, anthocyanes and other phenolic compounds of plant origin have been tested in vitro for their inhibitory effect on the enzyme adenosine deaminase (ADA).	Flavonoids	18-28	adenosine deaminase	Homo sapiens	155-174
1469950-2	1992	The effects of 20 flavonoids, anthocyanes and other phenolic compounds of plant origin have been tested in vitro for their inhibitory effect on the enzyme adenosine deaminase (ADA).	Flavonoids	18-28	adenosine deaminase	Homo sapiens	176-179
1349537-0	1992	Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite.	Flavonoids	13-25	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
1344193-8	1992	It was found that the activated form of aldose reductase is characterized by a lower affinity of the inhibitory center for the flavonoid, morin.	Flavonoids	127-136	aldose reductase	Bos taurus	40-56
1537302-0	1992	Thyroxine (T4) transport and distribution in rats treated with EMD 21388, a synthetic flavonoid that displaces T4 from transthyretin.	Flavonoids	86-95	transthyretin	Rattus norvegicus	119-132
1519447-3	1992	We have shown that competitive inhibition of T4-TTR binding sites in the CP and CSF by a flavonoid results in a decrease in the radioactivity present in the brain after i.v.	Flavonoids	89-98	transthyretin	Rattus norvegicus	48-51
1590889-1	1992	The protective effects of a series of phenolic compounds, phenolic acids and flavonoids on the cytotoxicity of CCl4 in rat hepatocytes were studied.	Flavonoids	77-87	C-C motif chemokine ligand 4	Rattus norvegicus	111-115
1733735-8	1992	We then used a synthetic flavonoid (EMD) that competitively inhibits binding of T4 to serum TTR and transiently increases serum free T4 to determine the role of choroid plexus TTR and CSF TTR in the transport of T4 from serum to brain.	Flavonoids	25-34	transthyretin	Rattus norvegicus	92-95
2065760-1	1991	The inhibitory potencies of different flavonoids for rat liver cytosolic glutathione S-transferase activity varied over 30-fold, depending on the pattern of hydroxylation, the presence of a C-2, C-3 double bond and the substitution of a hydroxyl group with a sugar moiety.	Flavonoids	38-48	complement C2	Rattus norvegicus	190-198
1553387-0	1992	In vitro inhibition and stimulation of purified prostaglandin endoperoxide synthase by flavonoids: structure-activity relationship.	Flavonoids	87-97	prostaglandin G/H synthase 1	Ovis aries	48-83
1553387-1	1992	We studied the effects of 37 flavonoids on prostaglandin endoperoxide synthase (EC 1.14.99.1) purified from sheep vesicular glands.	Flavonoids	29-39	prostaglandin G/H synthase 1	Ovis aries	43-78
1553387-6	1992	Several flavonoids, which were able to inhibit the prostaglandin endoperoxide synthase at higher concentrations, were also able to stimulate the enzyme at lower concentrations.	Flavonoids	8-18	prostaglandin G/H synthase 1	Ovis aries	51-86
1553387-7	1992	These results indicate that the flavonoids should be divided into two groups according to their capacity to inhibit the prostaglandin endoperoxide synthase, represented by planar and nonplanar substances as in each group a close correlation between structure and inhibitory activity was observed.	Flavonoids	32-42	prostaglandin G/H synthase 1	Ovis aries	120-155
1656994-0	1991	Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives.	Flavonoids	62-72	arachidonate 5-lipoxygenase	Homo sapiens	24-38
1656994-2	1991	We investigated the ability of various plant flavonoids (a) to inhibit 5-lipoxygenase and cyclooxygenase activities in rat peritoneal leukocytes, (b) to inhibit lipid peroxidation in rat liver microsomes, and (c) to stimulate DNA degradation caused by the antibiotic bleomycin in the presence of ferric ions.	Flavonoids	45-55	arachidonate 5-lipoxygenase	Rattus norvegicus	71-85
1656994-4	1991	The flavonoids were potent inhibitors of non-enzymatic peroxidation in membranes but this was not significantly correlated with their ability to inhibit either pathway of eicosanoid synthesis, suggesting that their mode of inhibition of 5-lipoxygenase/cyclooxygenase is not simply due to interception of peroxyl radicals generated at the active site of the enzymes.	Flavonoids	4-14	arachidonate 5-lipoxygenase	Homo sapiens	237-251
1656994-6	1991	Those flavonoids which stimulated DNA degradation at low concentrations but which inhibited it at higher concentrations ("biphasic" effect, possibly caused by changing relative contributions of ability to reduce ferric-bleomycin or to chelate iron ions from the bleomycin) were selective inhibitors of 5-lipoxygenase compared to cyclo-oxygenase.	Flavonoids	6-16	arachidonate 5-lipoxygenase	Homo sapiens	302-316
1772594-3	1991	Phosphorylation of a synthetic myosin light chain-related peptide by wheat embryo Ca(2+)-dependent protein kinase (CDPK) is also inhibited by a range of flavonoids but phosphorylation of histone preparation III-S by wheat CDPK is not inhibited by flavonoids.	Flavonoids	153-163	calcium-dependent protein kinase 19	Triticum aestivum	82-113
1772594-3	1991	Phosphorylation of a synthetic myosin light chain-related peptide by wheat embryo Ca(2+)-dependent protein kinase (CDPK) is also inhibited by a range of flavonoids but phosphorylation of histone preparation III-S by wheat CDPK is not inhibited by flavonoids.	Flavonoids	153-163	calcium-dependent protein kinase 19	Triticum aestivum	115-119
1772594-3	1991	Phosphorylation of a synthetic myosin light chain-related peptide by wheat embryo Ca(2+)-dependent protein kinase (CDPK) is also inhibited by a range of flavonoids but phosphorylation of histone preparation III-S by wheat CDPK is not inhibited by flavonoids.	Flavonoids	247-257	calcium-dependent protein kinase 19	Triticum aestivum	82-113
1772594-3	1991	Phosphorylation of a synthetic myosin light chain-related peptide by wheat embryo Ca(2+)-dependent protein kinase (CDPK) is also inhibited by a range of flavonoids but phosphorylation of histone preparation III-S by wheat CDPK is not inhibited by flavonoids.	Flavonoids	247-257	calcium-dependent protein kinase 19	Triticum aestivum	115-119
1772594-4	1991	The structural requirements for inhibition of wheat CDPK by flavonoids are more stringent than for inhibition of avian MLCK.	Flavonoids	60-70	calcium-dependent protein kinase 19	Triticum aestivum	52-56
1772594-5	1991	Potent flavonoid inhibitors of wheat CDPK are unsaturated in 2,3 position, have hydroxyl groups in positions 3" and 4" and an additional hydroxyl in the chromone ring.	Flavonoids	7-16	calcium-dependent protein kinase 19	Triticum aestivum	37-41
2026265-1	1991	Flavonoids activate nod gene expression in Rhizobium resulting in the synthesis of Nod signals which trigger organogenesis in the host plant.	Flavonoids	0-10	atrophin 1	Homo sapiens	20-23
2026265-1	1991	Flavonoids activate nod gene expression in Rhizobium resulting in the synthesis of Nod signals which trigger organogenesis in the host plant.	Flavonoids	0-10	atrophin 1	Homo sapiens	83-86
1831992-1	1991	Myricetin, a flavonoid, potently inhibits human erythrocyte plasma membrane Ca(2+)-pumping ATPase activity: half-maximal inhibition of the basal and calmodulin-stimulated activity is obtained with 6 microM myricetin.	Flavonoids	13-22	calmodulin 1	Homo sapiens	149-159
2155715-4	1990	Four selected flavonoids (Taxifolin, Eriodictyol, Hesperetin and Luteolin), inhibited myeloperoxidase (MPO) release, while two of these (Taxifolin and Eriodictyol) strongly inhibited MPO activity.	Flavonoids	14-24	myeloperoxidase	Homo sapiens	86-101
1763650-0	1991	Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase (SOD) enzyme.	Flavonoids	14-26	superoxide dismutase 1	Homo sapiens	80-100
1763650-0	1991	Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase (SOD) enzyme.	Flavonoids	14-26	superoxide dismutase 1	Homo sapiens	102-105
1842001-7	1991	Up to now, most nonpeptide compounds reported to exhibit BK antagonistic activity have been derived from plants, including many flavonoids, terpenes, and also synthetic substances with various molecular structures.	Flavonoids	128-138	kininogen 1	Homo sapiens	57-59
2268557-0	1990	Aromatase inhibition by flavonoids.	Flavonoids	24-34	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
2268557-8	1990	The relative binding affinities of the flavonoid analogs were determined and only ring A adn ring B dihydroxylated analogs were found to bind to the estrogen receptor.	Flavonoids	39-48	estrogen receptor 1	Homo sapiens	149-166
2344371-4	1990	The potencies of individual flavonoids in inhibiting LDL modification did not correlate with their previously determined potencies as inhibitors of 5-lipoxygenase and cyclo-oxygenase.	Flavonoids	28-38	arachidonate 5-lipoxygenase	Homo sapiens	148-162
2351100-0	1990	Flavonoid administration immediately displaces thyroxine (T4) from serum transthyretin, increases serum free T4, and decreases serum thyrotropin in the rat.	Flavonoids	0-9	transthyretin	Rattus norvegicus	73-86
2351100-1	1990	Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5"-deiodinase (5"-D) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (TTR).	Flavonoids	40-50	transthyretin	Rattus norvegicus	209-222
2351100-1	1990	Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5"-deiodinase (5"-D) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (TTR).	Flavonoids	40-50	transthyretin	Rattus norvegicus	224-227
1694261-0	1990	Inhibition of rat liver NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by flavonoids isolated from the Chinese herb scutellariae radix (Huang Qin).	Flavonoids	83-93	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	65-78
2155715-5	1990	Because CLlum is a MPO-dependent process these activities might mask effects of the flavonoids on ROS production.	Flavonoids	84-94	myeloperoxidase	Homo sapiens	19-22
2155715-7	1990	Flavonoids methylated at a single OH-group in the B-ring are only inhibitory when they react with activated neutrophils in the presence of myeloperoxidase.	Flavonoids	0-10	myeloperoxidase	Homo sapiens	139-154
2155715-4	1990	Four selected flavonoids (Taxifolin, Eriodictyol, Hesperetin and Luteolin), inhibited myeloperoxidase (MPO) release, while two of these (Taxifolin and Eriodictyol) strongly inhibited MPO activity.	Flavonoids	14-24	myeloperoxidase	Homo sapiens	103-106
2155715-4	1990	Four selected flavonoids (Taxifolin, Eriodictyol, Hesperetin and Luteolin), inhibited myeloperoxidase (MPO) release, while two of these (Taxifolin and Eriodictyol) strongly inhibited MPO activity.	Flavonoids	14-24	myeloperoxidase	Homo sapiens	183-186
33810944-2	2021	Cyanidin, a flavonoid compound, is a novel inhibitor of IL-17A/IL-17RA (receptor subunit A) interaction in several inflammatory diseases.	Flavonoids	12-21	interleukin 17A	Rattus norvegicus	56-62
33810944-2	2021	Cyanidin, a flavonoid compound, is a novel inhibitor of IL-17A/IL-17RA (receptor subunit A) interaction in several inflammatory diseases.	Flavonoids	12-21	interleukin 17 receptor A	Rattus norvegicus	63-70
33798836-3	2021	Flavonoids, especially rutin, have attracted considerable interest as a prospective SARS-CoV-2 main protease (Mpro) inhibitor.	Flavonoids	0-10	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	110-114
33804990-5	2021	Transcriptomic analysis of the imazethapyr-treated wild type and ros1 plants revealed a relation of the herbicide upregulated genes to chemical stimulus, secondary metabolism, stress condition, flavonoid biosynthesis, and epigenetic processes.	Flavonoids	194-203	demeter-like 1	Arabidopsis thaliana	65-69
33774316-0	2021	Total flavonoids of rhizoma drynariae ameliorates bone formation and mineralization in BMP-Smad signaling pathway induced large tibial defect rats.	Flavonoids	6-16	SMAD family member 1	Rattus norvegicus	91-95
33808505-10	2021	However, at least two of the predicted natural flavonoids were demonstrated to be effective P-gp inhibitors.	Flavonoids	47-57	ATP binding cassette subfamily B member 1	Homo sapiens	92-96
33765238-7	2022	Sterols 2-3 and flavonoid 11 induced the IC50 values of < 2.0 microg/mL better than the positive control acarbose (IC50 = 184.0 microg/mL) in alpha-glucosidase inhibitory assay.	Flavonoids	16-25	sucrase-isomaltase	Homo sapiens	142-159
33588047-3	2021	We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE).	Flavonoids	169-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-196
33588047-3	2021	We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE).	Flavonoids	169-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	203-207
33804990-6	2021	Hypersensitivity to imazethapyr of the flavonoid biosynthesis component TRANSPARENT TESTA 4 (TT4) mutant plants strongly suggests that ROS1-dependent accumulation of flavonoids is an important mechanism for herbicide stress response in A. thaliana.	Flavonoids	39-48	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	72-91
33804990-6	2021	Hypersensitivity to imazethapyr of the flavonoid biosynthesis component TRANSPARENT TESTA 4 (TT4) mutant plants strongly suggests that ROS1-dependent accumulation of flavonoids is an important mechanism for herbicide stress response in A. thaliana.	Flavonoids	39-48	demeter-like 1	Arabidopsis thaliana	135-139
33804990-6	2021	Hypersensitivity to imazethapyr of the flavonoid biosynthesis component TRANSPARENT TESTA 4 (TT4) mutant plants strongly suggests that ROS1-dependent accumulation of flavonoids is an important mechanism for herbicide stress response in A. thaliana.	Flavonoids	166-176	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	72-91
33804990-6	2021	Hypersensitivity to imazethapyr of the flavonoid biosynthesis component TRANSPARENT TESTA 4 (TT4) mutant plants strongly suggests that ROS1-dependent accumulation of flavonoids is an important mechanism for herbicide stress response in A. thaliana.	Flavonoids	166-176	demeter-like 1	Arabidopsis thaliana	135-139
33777154-13	2021	Conclusion: Baicalein, a medicine agent screened from natural flavonoids targeting TGFbeta pathway, could suppress mTOR/p70S6K pathway-mediated cell proliferation and EMT pathway-related migration via TGFbeta pathway in cervical cancer HeLa cells.	Flavonoids	62-72	transforming growth factor alpha	Homo sapiens	83-90
33799482-2	2021	Most efforts to verify flavonoid binding to nuclear receptors (NRs) and explain their action have been focused on ERalpha, while less attention has been paid to other nuclear and non-nuclear membrane androgen and estrogen receptors.	Flavonoids	23-32	estrogen receptor 1	Homo sapiens	114-121
33809299-0	2021	Flavonoids" Effects on Caenorhabditis elegans" Longevity, Fat Accumulation, Stress Resistance and Gene Modulation Involve mTOR, SKN-1 and DAF-16.	Flavonoids	0-10	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	128-133
33809299-0	2021	Flavonoids" Effects on Caenorhabditis elegans" Longevity, Fat Accumulation, Stress Resistance and Gene Modulation Involve mTOR, SKN-1 and DAF-16.	Flavonoids	0-10	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	138-144
33777154-13	2021	Conclusion: Baicalein, a medicine agent screened from natural flavonoids targeting TGFbeta pathway, could suppress mTOR/p70S6K pathway-mediated cell proliferation and EMT pathway-related migration via TGFbeta pathway in cervical cancer HeLa cells.	Flavonoids	62-72	mechanistic target of rapamycin kinase	Homo sapiens	115-119
33777154-3	2021	The present study aimed to screen the inhibitor of TGFbeta pathway from natural flavonoids and evaluate the function and mechanism of the TGFbeta pathway inhibitor on cervical cancer.	Flavonoids	80-90	transforming growth factor alpha	Homo sapiens	51-58
33236176-3	2021	A library of 44 citrus flavonoids was screened against the highly conserved Main Protease (Mpro) of SARS-CoV-2 using molecular docking.	Flavonoids	23-33	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	91-95
33236176-7	2021	It was observed that out of the 44 citrus flavonoids, five compounds showed lower binding energy with Mpro than the co-crystal ligand.	Flavonoids	42-52	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	102-106
32796123-0	2020	Brassinosteroid-Activated BRI1-EMS-SUPPRESSOR 1 Inhibits Flavonoid Biosynthesis and Coordinates Growth and UV-B Stress Responses in Plants.	Flavonoids	57-66	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	26-30
32796123-7	2020	These findings demonstrate that BR-activated BES1 not only promotes growth but also inhibits flavonoid biosynthesis.	Flavonoids	93-102	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	45-49
32796123-8	2020	UV-B stress suppresses the expression of BES1 to allocate energy to flavonoid biosynthesis and UV-B stress responses, allowing plants to switch from growth to UV-B stress responses in a timely manner.	Flavonoids	68-77	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	41-45
23993483-3	2013	Expression-based and phylogenetic evidence shows that TAS4 targets two novel grape (Vitis vinifera L.) MYB transcription factors (VvMYBA6, VvMYBA7) that spawn phased small interfering RNAs (siRNAs) which probably function in nutraceutical bioflavonoid biosynthesis and fruit development.	Flavonoids	239-251	transcription factor MYB90	Vitis vinifera	130-137
32796543-3	2020	The flavonoids decreased serum contents of malondialdehyde (MDA) and nitric oxide (NO), and increased serum total antioxidative capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) levels to different degrees in d-galactose-treated mice.	Flavonoids	4-14	catalase	Mus musculus	174-182
32796543-3	2020	The flavonoids decreased serum contents of malondialdehyde (MDA) and nitric oxide (NO), and increased serum total antioxidative capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) levels to different degrees in d-galactose-treated mice.	Flavonoids	4-14	catalase	Mus musculus	184-187
32796543-4	2020	The changes in mRNA expression of liver GSH-Px1, CAT, SOD1, and SOD2 by d-galactose were dissimilarly restored by the six flavonoids.	Flavonoids	122-132	glutathione peroxidase 1	Mus musculus	40-47
32796543-4	2020	The changes in mRNA expression of liver GSH-Px1, CAT, SOD1, and SOD2 by d-galactose were dissimilarly restored by the six flavonoids.	Flavonoids	122-132	catalase	Mus musculus	49-52
32796543-4	2020	The changes in mRNA expression of liver GSH-Px1, CAT, SOD1, and SOD2 by d-galactose were dissimilarly restored by the six flavonoids.	Flavonoids	122-132	superoxide dismutase 1, soluble	Mus musculus	54-58
32796543-4	2020	The changes in mRNA expression of liver GSH-Px1, CAT, SOD1, and SOD2 by d-galactose were dissimilarly restored by the six flavonoids.	Flavonoids	122-132	superoxide dismutase 2, mitochondrial	Mus musculus	64-68
32796543-5	2020	Moreover, the six flavonoids differentially prevented the inflammatory response caused by oxidative stress by inhibiting interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha levels, and restoring IL-10 levels.	Flavonoids	18-28	interleukin 1 alpha	Mus musculus	121-143
32796543-5	2020	Moreover, the six flavonoids differentially prevented the inflammatory response caused by oxidative stress by inhibiting interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha levels, and restoring IL-10 levels.	Flavonoids	18-28	interleukin 6	Mus musculus	145-149
32796543-5	2020	Moreover, the six flavonoids differentially prevented the inflammatory response caused by oxidative stress by inhibiting interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha levels, and restoring IL-10 levels.	Flavonoids	18-28	tumor necrosis factor	Mus musculus	155-188
32796543-5	2020	Moreover, the six flavonoids differentially prevented the inflammatory response caused by oxidative stress by inhibiting interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha levels, and restoring IL-10 levels.	Flavonoids	18-28	interleukin 10	Mus musculus	211-216
29192455-1	2017	Our preliminary study showed that the total flavonoids in Isodon amethystoides(TFIA), a local medicinal herb in Suzhou, had a certain therapeutic effect on adjuvant arthritis, and this therapeutic effect may be achieved through the up-regulation of miR-152 expression.	Flavonoids	44-54	microRNA 152	Rattus norvegicus	249-256
23902346-2	2013	The objective of this study was to investigate whether the natural flavonoid quercetin can inhibit matrix metalloproteinase (MMP)-2 and -9 activities through the attenuation of reactive oxygen species (ROS) formation, an event expected to lead to the inhibition of cell motility.	Flavonoids	67-76	matrix metallopeptidase 2	Homo sapiens	99-138
23993483-3	2013	Expression-based and phylogenetic evidence shows that TAS4 targets two novel grape (Vitis vinifera L.) MYB transcription factors (VvMYBA6, VvMYBA7) that spawn phased small interfering RNAs (siRNAs) which probably function in nutraceutical bioflavonoid biosynthesis and fruit development.	Flavonoids	239-251	R2R3 MYB transcription factor	Vitis vinifera	139-146
22701469-0	2012	Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1alpha-Mediated Fatty Acid Oxidation.	Flavonoids	80-90	PPARG coactivator 1 alpha	Homo sapiens	114-123
22701469-2	2012	Emerging evidence suggests the metabolic regulators, PPARalpha and PGC1alpha, are targets of the citrus flavonoids, and their activation may be at least partially responsible for mediating their metabolic effects.	Flavonoids	104-114	peroxisome proliferator activated receptor alpha	Homo sapiens	53-62
22701469-2	2012	Emerging evidence suggests the metabolic regulators, PPARalpha and PGC1alpha, are targets of the citrus flavonoids, and their activation may be at least partially responsible for mediating their metabolic effects.	Flavonoids	104-114	PPARG coactivator 1 alpha	Homo sapiens	67-76
34826543-0	2022	Total flavonoids of Oxytropis falcata Bunge have a positive effect on idiopathic pulmonary fibrosis by inhibiting the TGF-beta1/Smad signaling pathway.	Flavonoids	6-16	transforming growth factor, beta 1	Rattus norvegicus	118-127
7835232-6	1994	UGT2B15 stably expressed in HK293 cells displayed glucuronidation activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites.	Flavonoids	187-197	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	0-7
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	Flavonoids	28-38	sucrase-isomaltase	Homo sapiens	84-101
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	Flavonoids	28-38	L1 cell adhesion molecule	Mus musculus	145-149
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	Flavonoids	28-38	L1 cell adhesion molecule	Mus musculus	175-179
34563970-5	2022	Enzyme assays revealed that flavonoids exhibited higher inhibitory activity against alpha-glucosidase than others with astilbin (IC50 = 6.14 mug mL-1), morin (IC50 = 8.46 mug mL-1), and naringenin (IC50 = 10.03 mug mL-1) showing 2- to 4-fold higher potency than the positive control acarbose.	Flavonoids	28-38	L1 cell adhesion molecule	Mus musculus	215-219
34653779-0	2022	Starch-digesting product analysis based on the hydrophilic interaction liquid chromatography coupled mass spectrometry method to evaluate the inhibition of flavonoids on pancreatic alpha-amylase.	Flavonoids	156-166	amylase alpha 2A	Homo sapiens	170-194
34826543-0	2022	Total flavonoids of Oxytropis falcata Bunge have a positive effect on idiopathic pulmonary fibrosis by inhibiting the TGF-beta1/Smad signaling pathway.	Flavonoids	6-16	SMAD family member 7	Rattus norvegicus	128-132
34699766-0	2022	The PPARgamma-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells.	Flavonoids	34-43	peroxisome proliferator activated receptor gamma	Homo sapiens	4-13
34737006-7	2022	RESULTS: Treatment with flavonoids significantly ameliorated BPH-associated prostate inflammation and inhibited the expression of COX-2 and 5-LOX at the protein and mRNA levels.	Flavonoids	24-34	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	130-141
34626776-9	2022	RESULTS: Our study revealed alkaloids, flavonoids, and polysaccharides in mulberry leaf could increase the levels of PK, HK, and ALT/GPT, and decrease the levels of TG and T-Cho significantly, and regulate glucose, amino acid, and lipid metabolism.	Flavonoids	39-49	glutamic pyruvic transaminase, soluble	Mus musculus	129-132
34626776-9	2022	RESULTS: Our study revealed alkaloids, flavonoids, and polysaccharides in mulberry leaf could increase the levels of PK, HK, and ALT/GPT, and decrease the levels of TG and T-Cho significantly, and regulate glucose, amino acid, and lipid metabolism.	Flavonoids	39-49	glutamic pyruvic transaminase, soluble	Mus musculus	133-136
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	38-48	complement C2	Homo sapiens	74-83
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	38-48	sucrase-isomaltase	Homo sapiens	293-310
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	38-48	sucrase-isomaltase	Homo sapiens	386-403
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	169-179	complement C2	Homo sapiens	74-83
34500290-3	2022	Considering the chemical structure of flavonoids, the double bond between C2 and C3 and OH groups at A5 and B3 are critical for the inhibition of alpha-amylase allowing flavonoids to lie parallel on the alpha-amylase catalytic active site, whereas the OH groups at B3 and C3 are important for alpha-glucosidase inhibition causing B-ring specific entry into the catalytic active site of alpha-glucosidase.	Flavonoids	169-179	sucrase-isomaltase	Homo sapiens	386-403
34560084-9	2022	This review aims to discuss what is currently known about the potential for high dose flavonoids to interact with the hepatic CYP450 metabolism, OATP uptake of statins or their ability to interact with HMG-CoA reductase.	Flavonoids	86-96	solute carrier organic anion transporter family member 1A2	Homo sapiens	145-149
34655725-8	2022	Our results indicated that ectopic expression of AtCPC in tobacco not only decreased the flavonoid compound accumulation, but also up-regulated several lignin biosynthetic genes, and significantly increased the accumulation of lignin.	Flavonoids	89-98	Homeodomain-like superfamily protein	Arabidopsis thaliana	49-54
34666140-1	2022	ETHNOPHARMACOLOGICAL RELEVANCE: Baicalin (BI) is an important biologically active flavonoid isolated from the root of Scutellaria radix (Huang Qin).	Flavonoids	82-91	forkhead box G1	Homo sapiens	143-146
34761560-7	2022	The presence of  OH groups at the C-3, C-8, C-4" positions of flavonoids is suggested to be favorable for the inhibition of SGK1 activity.	Flavonoids	62-72	serum/glucocorticoid regulated kinase 1	Homo sapiens	124-128
34461524-0	2022	Fluorescence discrimination of HSA from BSA: A close look at the albumin-induced restricted intramolecular rotation of flavonoid probe.	Flavonoids	119-128	albumin	Homo sapiens	65-72
34543663-12	2022	Because BX795 completely prevents Alpinone-dependent upregulation of IFNa and IRF3, the flavonoid targets seem to be upstream of the kinases TBK1 and IKKepsilon.	Flavonoids	88-97	serine/threonine-protein kinase TBK1	Salmo salar	141-145
34625952-10	2022	Furthermore, treatment with AhR short hairpin RNA or flavonoids inhibited mRNA expression of AhR and its target genes in 1-hydroxypyrene-induced HK-2 cells and mice.	Flavonoids	53-63	aryl-hydrocarbon receptor	Mus musculus	93-96
34811762-9	2022	LCA is a small molecule flavonoid extracted from the root of licorice.	Flavonoids	24-33	clathrin, light polypeptide (Lca)	Mus musculus	0-3
34743931-8	2022	We conclude that 3HPPA mitigates the adhesion of monocytes to endothelial cells by suppressing the expression of the cell adhesion molecule E-selectin in HAECs via inhibition of the NF-kappaB pathway, providing additional evidence for the health benefits of dietary flavonoids and their microbial metabolites as therapeutic agents in atherosclerosis.	Flavonoids	266-276	selectin E	Homo sapiens	140-150
34914114-4	2022	This study aimed to study the neuroprotective effects of phenolic acids and flavonoid-rich HWG against hydrogen peroxide (H2 O2 )-induced oxidative damage in PC12 cells and its inhibitory effect on acetylcholinesterase (AChE).	Flavonoids	76-85	acetylcholinesterase	Rattus norvegicus	198-218
34914114-4	2022	This study aimed to study the neuroprotective effects of phenolic acids and flavonoid-rich HWG against hydrogen peroxide (H2 O2 )-induced oxidative damage in PC12 cells and its inhibitory effect on acetylcholinesterase (AChE).	Flavonoids	76-85	acetylcholinesterase	Rattus norvegicus	220-224
34820749-3	2022	As one of the dietary flavonoids, kaempferol, has been shown to be antiproliferative and might have a protective effect against TRAIL resistance, particularly for hematologic malignancies.	Flavonoids	22-32	TNF superfamily member 10	Homo sapiens	128-133
34736055-6	2022	Binding trajectories revealed the tightest interaction modes for two flavonoid molecules (acerosin and nevadensin) in the uracil DNA glycolase (UDG) active site.	Flavonoids	69-78	uracil DNA glycosylase	Homo sapiens	144-147
34736055-11	2022	Although primary mechanisms of action are yet to be discovered, UDG may be a promising target for developing antileishmanial flavonoids.	Flavonoids	125-135	uracil DNA glycosylase	Homo sapiens	64-67
34969954-4	2021	Initial molecular docking results predicted ideal docked poses (- 9.346 to - 5.795 kcal/mol) for tyrosinase with selected flavonoids.	Flavonoids	122-132	tyrosinase	Mus musculus	97-107
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Flavonoids	79-89	NFE2 like bZIP transcription factor 2	Homo sapiens	279-283
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Flavonoids	79-89	AKT serine/threonine kinase 1	Homo sapiens	292-295
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Flavonoids	79-89	NLR family pyrin domain containing 3	Homo sapiens	319-324
34856476-6	2022	RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-kappaB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-alpha, and RA.	Flavonoids	79-89	tumor necrosis factor	Homo sapiens	326-335
34837635-6	2022	Both flavonoids effectively prevented oxidative damage, such as ROS generation, glutathione depletion, single-strand breaks formation and caspase-3 activation in NHDF.	Flavonoids	5-15	caspase 3	Homo sapiens	138-147
34969954-5	2021	Furthermore, 100 ns molecular dynamics simulations and post-simulation analysis of docked poses established their stability and oxidation of flavonoids as substrate by tyrosinase.	Flavonoids	141-151	tyrosinase	Mus musculus	168-178
34939529-10	2021	The extract inhibited NO and IL-6 production at 100 and 200 microg/mL, while flavonoid-rich fraction possessed significant anti-inflammatory activity at the concentration of 50 and 100 microg/mL via NO and IL-6 production, respectively.	Flavonoids	77-86	interleukin 6	Mus musculus	206-210
34780892-5	2021	The mechanism of action of Ram2 towards rutin was elucidated and revealed the potential cost-effective and selective production of the monoglycosylated flavonoid isoquercetin (quercetin-3-O-glucoside).	Flavonoids	152-161	alpha-L-rhamnosidase	Lactobacillus plantarum WCFS1	27-31
34931736-3	2022	This study aimed to investigate whether the gossypin (GOS) with antioxidant properties, a flavonoid, has beneficial effects on the biochemical, molecular, and histopathological aspects of ovarian I/R injury.	Flavonoids	90-99	insulin receptor	Homo sapiens	196-199
34992384-9	2021	SF-F2 was most effective in increasing IL-10, whereas SF-F4 (flavonoid compounds) was most effective in suppressing IL-5 production.	Flavonoids	61-70	interleukin 5	Homo sapiens	116-120
34780892-7	2021	These findings revealed the potential usefulness of PPO for the improvement of sensory properties of beverages through debittering of citrus juices, as well as the potential use of Ram2 to selectively produce isoquercetin, a highly valued and bioactive flavonoid whose production is not currently affordable.	Flavonoids	253-262	alpha-L-rhamnosidase	Lactobacillus plantarum WCFS1	181-185
34945647-7	2021	Flavonoids modulated the effects of carotenoids on the expression of active transporters scavenger receptor class B type I (SR-BI) or Niemann-Pick C1-like 1 (NPC1L1).	Flavonoids	0-10	scavenger receptor class B member 1	Homo sapiens	89-122
34945647-7	2021	Flavonoids modulated the effects of carotenoids on the expression of active transporters scavenger receptor class B type I (SR-BI) or Niemann-Pick C1-like 1 (NPC1L1).	Flavonoids	0-10	scavenger receptor class B member 1	Homo sapiens	124-129
34945647-7	2021	Flavonoids modulated the effects of carotenoids on the expression of active transporters scavenger receptor class B type I (SR-BI) or Niemann-Pick C1-like 1 (NPC1L1).	Flavonoids	0-10	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	158-164
34946657-0	2021	Suppressing Alpha-Hemolysin as Potential Target to Screen of Flavonoids to Combat Bacterial Coinfection.	Flavonoids	61-71	AT695_RS11870	Staphylococcus aureus	12-27
34906197-0	2021	Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth.	Flavonoids	0-10	nuclear receptor subfamily 4 group A member 1	Homo sapiens	40-60
34906197-0	2021	Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth.	Flavonoids	0-10	nuclear receptor subfamily 4 group A member 1	Homo sapiens	62-67
34906197-0	2021	Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth.	Flavonoids	0-10	nuclear receptor subfamily 4 group A member 1	Homo sapiens	69-74
34863225-0	2021	Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced Osteoporosis in rats via the regulation of Wnt3a/beta-catenin pathway.	Flavonoids	24-34	Wnt family member 3A	Rattus norvegicus	158-163
34946631-0	2021	Insights on the Inhibitory Power of Flavonoids on Tyrosinase Activity: A Survey from 2016 to 2021.	Flavonoids	36-46	tyrosinase	Homo sapiens	50-60
34946631-4	2021	Among these bioactive compounds, flavonoids represent a huge natural class with different categories such as flavones, flavonols, isoflavones, flavan-3-ols, flavanones and chalcones that display antioxidant and tyrosinase inhibitor activities with a diversity of mechanistic approaches.	Flavonoids	33-43	tyrosinase	Homo sapiens	211-221
34946631-5	2021	In this review, we explore the role of novel or known flavonoids isolated from different plant species and their participation as tyrosinase inhibitors reported in the last five years from 2016 to 2021.	Flavonoids	54-64	tyrosinase	Homo sapiens	130-140
34946519-5	2021	It was observed that the ability to inhibit PTP1B is dependent on the nature, position, and number of sugar moieties in the flavonoid structure, as well as conjugation.	Flavonoids	124-133	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	44-49
34863225-0	2021	Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced Osteoporosis in rats via the regulation of Wnt3a/beta-catenin pathway.	Flavonoids	24-34	catenin beta 1	Rattus norvegicus	164-176
34700230-8	2021	RESULTS: The bioactive components of CP inhibiting HepG2 cells were mainly flavonoids, and esters.	Flavonoids	75-85	ceruloplasmin	Homo sapiens	37-39
34884854-6	2021	Importantly, transcriptional regulation prediction showed that six key WRKY genes contribute to four major defense-related pathways: L-phenylalanine biosynthesis II and flavonoid, benzoxazinoid, and jasmonic acid (JA) biosynthesis.	Flavonoids	169-178	WRKY transcription factor WRKY76	Zea mays	71-75
34560999-2	2021	Here, we show how digestible starch and flavonoids can be used as a dietary approach to manage food intake and weight gain through elevation of glucagon-like peptide-1 (GLP-1) secretion for gut-brain axis communication.	Flavonoids	40-50	glucagon	Mus musculus	144-167
34560999-2	2021	Here, we show how digestible starch and flavonoids can be used as a dietary approach to manage food intake and weight gain through elevation of glucagon-like peptide-1 (GLP-1) secretion for gut-brain axis communication.	Flavonoids	40-50	glucagon	Mus musculus	169-174
34519118-1	2021	AIMS: Flavonoids and related compounds, such as quercetin-based antiviral drug Gene-Eden-VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus (SARS-CoV-2).	Flavonoids	6-16	novirin	None	93-100
34599545-3	2021	In this study, we investigated the effect of 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), an useful flavonoid, to overcome the TRAIL-resistant triple negative breast cancer (TNBC) cells.	Flavonoids	114-123	TNF superfamily member 10	Homo sapiens	141-146
34758440-3	2021	In this study, the effects of 16 known sesquiterpene lactones and flavonoids from I. Flos on TGF-beta1-induced fibroblast activation were assessed by phenotypic high-content screening.	Flavonoids	66-76	transforming growth factor, beta 1	Rattus norvegicus	93-102
34755444-7	2021	Both flavonoids induced apoptosis, accompanied by activation of caspase-3, caspase-7, caspase-8 and caspase-9.	Flavonoids	5-15	caspase 3	Homo sapiens	64-73
34755444-7	2021	Both flavonoids induced apoptosis, accompanied by activation of caspase-3, caspase-7, caspase-8 and caspase-9.	Flavonoids	5-15	caspase 7	Homo sapiens	75-84
34755444-7	2021	Both flavonoids induced apoptosis, accompanied by activation of caspase-3, caspase-7, caspase-8 and caspase-9.	Flavonoids	5-15	caspase 8	Homo sapiens	86-95
34755444-7	2021	Both flavonoids induced apoptosis, accompanied by activation of caspase-3, caspase-7, caspase-8 and caspase-9.	Flavonoids	5-15	caspase 9	Homo sapiens	100-109
33980119-0	2021	Flavonoids as inhibitors of human neutrophil elastase.	Flavonoids	0-10	elastase, neutrophil expressed	Homo sapiens	34-53
33980119-4	2021	Among polyphenolic compounds, some flavonoids and their derivatives, which are mostly found in herbal plants, have been revealed to influence elastase release and its action on human cells.	Flavonoids	35-45	elastase, neutrophil expressed	Homo sapiens	142-150
33980119-5	2021	This review focuses on elastase inhibitors that have been discovered from natural sources and are biochemically characterised as flavonoids.	Flavonoids	129-139	elastase, neutrophil expressed	Homo sapiens	23-31
33980119-6	2021	The inhibitory activity on elastase is a characteristic of flavonoid aglycones and their glycoside and methylated, acetylated and hydroxylated derivatives.	Flavonoids	59-68	elastase, neutrophil expressed	Homo sapiens	27-35
34776627-1	2021	In prostate cancer, flavonoids possess a wide variety of anticancer effects, focused on the antioxidant/pro-oxidant activity, inactivation of the androgen receptor, cell cycle arrest, apoptosis induction, metastasis inhibition, among others.	Flavonoids	20-30	androgen receptor	Homo sapiens	146-163
34730855-6	2021	In addition, ascorbic acid prevented the browning of fresh-cut apples by increasing APX activity and inhibiting PPO and POD activities which reduce the oxidation of total phenolics and flavonoids.	Flavonoids	185-195	polyphenol oxidase, chloroplastic	Malus domestica	112-115
34669098-2	2021	Moreover, plant-based foods containing flavonoids were previously reported to show neuroprotective effects by modulating self-aggregation of amyloid-beta (Abeta)/or tau peptide into oligomers and fibrils, associated with the pathogenesis of AD.	Flavonoids	39-49	amyloid beta (A4) precursor protein	Mus musculus	155-160
34512097-5	2021	We investigated the drug-likeness of the plant"s active constituents, such as alkaloids, polyphenols, and flavonoids, as well as their binding affinity for the RdRp enzyme.	Flavonoids	106-116	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	160-164
34712357-6	2021	Overall, the findings from the present study demonstrated that delphinidin treatment could induce the mitochondrial apoptosis pathway in human HER-2-positive breast cancer cell lines, providing an experimental basis for the prevention and treatment of HER-2-positive breast cancer by flavonoids.	Flavonoids	284-294	erb-b2 receptor tyrosine kinase 2	Homo sapiens	252-257
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	tumor necrosis factor	Homo sapiens	223-232
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	interleukin 1 alpha	Homo sapiens	234-242
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	interleukin 6	Homo sapiens	244-248
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	interleukin 17A	Homo sapiens	260-265
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	interleukin 2	Homo sapiens	296-300
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	interleukin 10	Homo sapiens	305-310
34842001-4	2021	Moreover, flavonoid intake had negative but non-significant effect on insulin (MD: -0.46), 2 h-postprandial glucose (2 h-PPG) (MD: -0.22), homeostasis model assessment of beta-cell function (HOMA-beta) (MD: -2.81), and insignificantly increased high-density lipoprotein-C (HDL-C) (MD: 0.03).	Flavonoids	10-19	insulin	Homo sapiens	70-77
34944613-0	2021	Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms.	Flavonoids	59-68	cathepsin D	Mus musculus	0-7
34887704-0	2021	Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin.	Flavonoids	83-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-52
34842001-5	2021	In conclusion, flavonoid intake has modest but statistically significant benefits in glucose metabolism, insulin sensitivity, and lipid metabolism, especially for significantly lowing fasting blood glucose, HOMA-IR, HbA1c, TG, TC, and LDL-C.	Flavonoids	15-24	insulin	Homo sapiens	105-112
34887716-2	2021	The water extract of Lycium barbarum berry (Lyc), containing water-soluble Lycium barbarum polysaccharides and flavonoids, can protect the neuronal injury by reducing oxidative stress and suppressing neuroinflammation.	Flavonoids	111-121	CD8 antigen, beta chain 1	Mus musculus	44-47
34885792-0	2021	Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach.	Flavonoids	84-94	glucokinase	Homo sapiens	16-27
34885792-2	2021	This study was designed to identify potent glucokinase activators from prenylated flavonoids isolated from medicinal plants using molecular docking, molecular dynamics simulation, density functional theory, and ADMET analysis.	Flavonoids	82-92	glucokinase	Homo sapiens	43-54
34885792-3	2021	Virtual screening was carried out on glucokinase enzymes using 221 naturally occurring prenylated flavonoids, followed by molecular dynamics simulation (100 ns), density functional theory (B3LYP model), and ADMET (admeSar 2 online server) studies.	Flavonoids	98-108	glucokinase	Homo sapiens	37-48
34885792-7	2021	Our findings suggested further evaluation of the top-ranked prenylated flavonoids for their in vitro and in vivo glucokinase activating potentials.	Flavonoids	71-81	glucokinase	Homo sapiens	113-124
34884435-0	2021	A Talk between Flavonoids and Hormones to Reorient the Growth of Gymnosperms.	Flavonoids	15-25	bone morphogenetic protein receptor type 2	Homo sapiens	2-6
34821532-7	2021	Flavonoids strongly inhibited SARS-CoV-2 Mpro with comparable or higher potency than the antiviral drug, remdesivir.	Flavonoids	0-10	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	41-45
34806280-5	2022	miRNA can regulate the formation of flavonoids by acting on structural genes or indirectly by using an MBW transcription complex comprising MYB-bHLH-WD40.	Flavonoids	36-46	MYB proto-oncogene, transcription factor	Homo sapiens	140-143
34836440-0	2021	Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells.	Flavonoids	0-9	basic transcription factor 3 pseudogene 11	Homo sapiens	56-59
34887836-7	2021	The effects these flavonoids have on the mitogen activated protein kinase (MAPK), nuclear factor kappa beta (NF-kbeta), Wnt/beta-catenin and bone morphogenetic protein 2/SMAD (BMP2/SMAD) signalling pathways, and apoptotic pathways lead to impacts on bone remodelling.	Flavonoids	18-28	catenin beta 1	Homo sapiens	124-136
34887836-7	2021	The effects these flavonoids have on the mitogen activated protein kinase (MAPK), nuclear factor kappa beta (NF-kbeta), Wnt/beta-catenin and bone morphogenetic protein 2/SMAD (BMP2/SMAD) signalling pathways, and apoptotic pathways lead to impacts on bone remodelling.	Flavonoids	18-28	bone morphogenetic protein 2	Homo sapiens	141-174
34887836-7	2021	The effects these flavonoids have on the mitogen activated protein kinase (MAPK), nuclear factor kappa beta (NF-kbeta), Wnt/beta-catenin and bone morphogenetic protein 2/SMAD (BMP2/SMAD) signalling pathways, and apoptotic pathways lead to impacts on bone remodelling.	Flavonoids	18-28	bone morphogenetic protein 2	Homo sapiens	176-180
34811448-11	2021	TFR-1 was discovered to be the dominating microbial strain in TFR, increasing total phenolic and flavonoid content in the fermented solution of Rosa "Dianhong" by 0.45 mg GAE/ml and 0.60 mg RE/ml, respectively, after 30 days.	Flavonoids	97-106	transferrin receptor	Homo sapiens	0-5
34830339-0	2021	Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach.	Flavonoids	45-55	AKT serine/threonine kinase 1	Homo sapiens	15-18
34830339-0	2021	Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach.	Flavonoids	45-55	mechanistic target of rapamycin kinase	Homo sapiens	19-23
34830339-8	2021	This article summarizes the key progress made in this area and discusses the role of flavonoids by specifically inhibiting the PI3K/Akt/mTOR pathway in various cancers.	Flavonoids	85-95	AKT serine/threonine kinase 1	Homo sapiens	132-135
34830339-8	2021	This article summarizes the key progress made in this area and discusses the role of flavonoids by specifically inhibiting the PI3K/Akt/mTOR pathway in various cancers.	Flavonoids	85-95	mechanistic target of rapamycin kinase	Homo sapiens	136-140
34834833-6	2021	Overall, our review revealed support for the claims that the red and blue LED illumination is more reliable and efficient than full spectrum illumination and increases the plant"s biomass and nutritional value by enhancing the photosynthetic activity, antioxidant properties, phenolic, and flavonoids contents.	Flavonoids	290-300	small integral membrane protein 10 like 2A	Homo sapiens	74-77
34787055-6	2021	Considering the OMgp as the target protein, two flavonoid libraries (curcumin and piperine) were screened against it to get potential inhibitors.	Flavonoids	48-57	oligodendrocyte myelin glycoprotein	Homo sapiens	16-20
34833955-6	2021	In this study, a series of phytobioactives were screened based on their chemical classes such as coumarins, flavonoids, and triterpenoids for their action on NQO1.	Flavonoids	108-118	NAD(P)H quinone dehydrogenase 1	Homo sapiens	158-162
34829893-8	2021	Therefore, AOX1 alone or combined with flavonoids holds promise as a chemoprotectant by reducing ROS and DNA damage to attenuate activation of ATR kinase following carcinogen exposure.	Flavonoids	39-49	ATR serine/threonine kinase	Homo sapiens	143-146
34803702-0	2021	Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression.	Flavonoids	7-17	toll-like receptor 4	Mus musculus	111-115
34829051-3	2021	In this study, various natural products found in apples such as flavonoids, glutathione (GSH), and glutathione disulfide (GSSG) were investigated as possible ligands of Mal d 1 using microscale thermophoresis.	Flavonoids	64-74	major allergen Mal d 1	Malus domestica	169-176
34858164-4	2021	It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/beta-catenin signaling pathways were reported to be implicated in these protective effects.	Flavonoids	49-59	NFE2 like bZIP transcription factor 2	Homo sapiens	191-195
34858164-4	2021	It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/beta-catenin signaling pathways were reported to be implicated in these protective effects.	Flavonoids	49-59	heme oxygenase 1	Homo sapiens	196-200
34858164-4	2021	It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/beta-catenin signaling pathways were reported to be implicated in these protective effects.	Flavonoids	49-59	cathelicidin antimicrobial peptide	Homo sapiens	218-222
34858164-4	2021	It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/beta-catenin signaling pathways were reported to be implicated in these protective effects.	Flavonoids	49-59	catenin beta 1	Homo sapiens	236-248
34771127-6	2021	Correlation analysis indicated that the main galloylated catechins and flavonoid glycosides were highly related to their antioxidant capacity and inhibitory effects on alpha-amylase and alpha-glucosidase.	Flavonoids	71-80	sucrase-isomaltase	Homo sapiens	186-203
34803702-7	2021	In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats.	Flavonoids	24-34	tumor necrosis factor	Rattus norvegicus	158-185
34830091-0	2021	The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.	Flavonoids	15-24	protein arginine N-methyltransferase 7	Mus musculus	132-137
34830091-0	2021	The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.	Flavonoids	15-24	thymoma viral proto-oncogene 3	Mus musculus	138-142
34769407-5	2021	As high lignin content determines lower saccharification yields for the biomass, we opted for a biotechnological approach, with the purpose of reducing lignin content; we generated transgenic lines overexpressing the Arabidopsis thaliana MYB4 transcription factor, a known repressor of lignin/flavonoid biosynthesis.	Flavonoids	293-302	myb domain protein 4	Arabidopsis thaliana	238-242
34803702-7	2021	In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats.	Flavonoids	24-34	tumor necrosis factor	Rattus norvegicus	187-196
34803702-0	2021	Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression.	Flavonoids	7-17	myeloid differentiation primary response gene 88	Mus musculus	116-121
34803702-7	2021	In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats.	Flavonoids	24-34	interleukin 1 beta	Rattus norvegicus	202-220
34803702-7	2021	In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats.	Flavonoids	24-34	interleukin 1 alpha	Rattus norvegicus	222-230
34803702-0	2021	Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression.	Flavonoids	7-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	122-131
34803702-8	2021	Furthermore, Western blot analysis indicated that the active flavonoids reduced the production of these cytokines by inhibiting the TLR4/MyD88/NF-kappaB pathway and decreasing NLRP3 expression in synovial tissues of rats.	Flavonoids	61-71	toll-like receptor 4	Rattus norvegicus	132-136
34803702-8	2021	Furthermore, Western blot analysis indicated that the active flavonoids reduced the production of these cytokines by inhibiting the TLR4/MyD88/NF-kappaB pathway and decreasing NLRP3 expression in synovial tissues of rats.	Flavonoids	61-71	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	137-142
34803702-8	2021	Furthermore, Western blot analysis indicated that the active flavonoids reduced the production of these cytokines by inhibiting the TLR4/MyD88/NF-kappaB pathway and decreasing NLRP3 expression in synovial tissues of rats.	Flavonoids	61-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
34803702-8	2021	Furthermore, Western blot analysis indicated that the active flavonoids reduced the production of these cytokines by inhibiting the TLR4/MyD88/NF-kappaB pathway and decreasing NLRP3 expression in synovial tissues of rats.	Flavonoids	61-71	NLR family, pyrin domain containing 3	Rattus norvegicus	176-181
34803702-10	2021	In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis.	Flavonoids	55-65	toll-like receptor 4	Mus musculus	167-171
34803702-0	2021	Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression.	Flavonoids	7-17	NLR family, pyrin domain containing 3	Mus musculus	144-149
34803702-10	2021	In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis.	Flavonoids	55-65	myeloid differentiation primary response gene 88	Mus musculus	172-177
34803702-10	2021	In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis.	Flavonoids	55-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-187
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Flavonoids	95-104	insulin like growth factor 1	Homo sapiens	153-181
34803702-10	2021	In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis.	Flavonoids	55-65	NLR family, pyrin domain containing 3	Mus musculus	200-205
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Flavonoids	95-104	insulin like growth factor 1	Homo sapiens	183-188
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Flavonoids	95-104	insulin like growth factor 2	Homo sapiens	194-222
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Flavonoids	95-104	insulin like growth factor 2	Homo sapiens	224-230
34106520-11	2021	CONCLUSION: YS-10, a novel synthesized flavonoid compound, could effectively improve erectile dysfunction in rats after BCNI by alleviating pathological impairments; this effect may associate with the upregulation of beta-Catenin and cyclin D1 in Wnt signaling pathway.	Flavonoids	39-48	catenin beta 1	Rattus norvegicus	217-229
34727985-3	2021	During the present investigation, we have examined different flavonoids that target protein kinases B (AKT1) protein which exerts their anticancer efficiency intriguing the role in cross-talk cell signalling, by metabolic processes through in-silico approaches.	Flavonoids	61-71	AKT serine/threonine kinase 1	Homo sapiens	103-107
34795590-2	2021	Coffee peel (CP) preparations are consumed as beverages, and their total polyphenol or flavonoid content and their effect on oxidative stress-induced human mesenchymal stem cells (hMSCs) are poorly understood.	Flavonoids	87-96	carboxypeptidase E	Homo sapiens	13-15
34900535-6	2021	3,5,6,7,8,3",4"-Heptamethoxyflavone (HMF), a citrus flavonoid, was found to target FKBP38 to suppress the mTOR/P70S6K/SREBPs pathway, reduce lipid level, and potently ameliorate hyperlipidemia and insulin resistance in high fat diet (HFD)-fed mice.	Flavonoids	52-61	FK506 binding protein 8	Mus musculus	83-89
34106520-11	2021	CONCLUSION: YS-10, a novel synthesized flavonoid compound, could effectively improve erectile dysfunction in rats after BCNI by alleviating pathological impairments; this effect may associate with the upregulation of beta-Catenin and cyclin D1 in Wnt signaling pathway.	Flavonoids	39-48	cyclin D1	Rattus norvegicus	234-243
34488124-12	2021	This work helps to understand transport, distribution, bioactivity, and design of flavonoid-based GSK-3beta inhibitors.	Flavonoids	82-91	glycogen synthase kinase 3 alpha	Homo sapiens	98-107
34951183-0	2021	(Total flavonoids of Drynariae Rhizoma regulates ER-p38 MAPK signaling pathway to improve scopolamine-induced learning and memory impairments in model mice).	Flavonoids	7-17	mitogen-activated protein kinase 14	Mus musculus	52-60
34396710-0	2021	The flavonoid Astragalin shows antitumor activity and inhibits PI3K/AKT signaling in gastric cancer.	Flavonoids	4-13	thymoma viral proto-oncogene 1	Mus musculus	68-71
34854271-8	2021	Both flavonoids increased glucose uptake by promoting the phosphorylation of AMPK at Thr172 and increased the phosphorylation of GSK3beta.	Flavonoids	5-15	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	77-81
34854271-8	2021	Both flavonoids increased glucose uptake by promoting the phosphorylation of AMPK at Thr172 and increased the phosphorylation of GSK3beta.	Flavonoids	5-15	glycogen synthase kinase 3 alpha	Homo sapiens	129-137
34951178-6	2021	The anti-oxidative effect in vivo of LRH flavonoids on liver superoxide dismutase(SOD), catalase(CAT), and malondialdehyde(MDA) levels was determined based on the chronic/subacute aging model in mice induced by D-galactose.	Flavonoids	41-51	catalase	Mus musculus	88-96
34951178-6	2021	The anti-oxidative effect in vivo of LRH flavonoids on liver superoxide dismutase(SOD), catalase(CAT), and malondialdehyde(MDA) levels was determined based on the chronic/subacute aging model in mice induced by D-galactose.	Flavonoids	41-51	catalase	Mus musculus	97-100
34951178-12	2021	Additionally, LRH flavonoids could improve the carbon clearance index in immunosuppressed mice, potentiate the activities of SOD and CAT and reduce MDA levels in the liver of aging mice induced by D-galactose, and effectively inhibit macrophage pyroptosis by decreasing the levels of caspase-1, IL-1beta, and IL-18.	Flavonoids	18-28	catalase	Mus musculus	133-136
34951178-12	2021	Additionally, LRH flavonoids could improve the carbon clearance index in immunosuppressed mice, potentiate the activities of SOD and CAT and reduce MDA levels in the liver of aging mice induced by D-galactose, and effectively inhibit macrophage pyroptosis by decreasing the levels of caspase-1, IL-1beta, and IL-18.	Flavonoids	18-28	caspase 1	Mus musculus	284-293
34539858-0	2021	EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.	Flavonoids	32-41	epidermal growth factor receptor	Homo sapiens	0-4
34539858-0	2021	EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.	Flavonoids	32-41	mitogen-activated protein kinase 1	Homo sapiens	9-12
34539858-2	2021	The results suggested that the natural flavonoid quercetin (Que), the effective antitumor ingredient in SH, which is widely present in a variety of plants, may depend on the target, EGFR.	Flavonoids	39-48	epidermal growth factor receptor	Homo sapiens	182-186
34759740-2	2021	Previous in vitro studies discovered that the flavonoid-rich extract of this plant has potential hypotensive effects, specifically angiotensin-converting enzyme (ACE)-inhibitory activity.	Flavonoids	46-55	angiotensin I converting enzyme	Rattus norvegicus	131-160
34411613-1	2021	In the present work, lactoferrin (Lf) based nanoparticle incorporated self-supporting gel encapsulating a flavonoid, quercetin (Q), was developed.	Flavonoids	106-115	lactotransferrin	Rattus norvegicus	21-32
34951183-8	2021	Compared with the model group, the total flavonoids of Rhizoma Drynariae increased the expression of ERbeta and SOD in the hippocampus, down-regulated the expression of neuronal pro-apoptotic proteins, up-re-gulated the expression of anti-apoptotic proteins, and reduced p-p38/p38, MDA, and NO.	Flavonoids	41-51	estrogen receptor 1 (alpha)	Mus musculus	101-115
34951183-8	2021	Compared with the model group, the total flavonoids of Rhizoma Drynariae increased the expression of ERbeta and SOD in the hippocampus, down-regulated the expression of neuronal pro-apoptotic proteins, up-re-gulated the expression of anti-apoptotic proteins, and reduced p-p38/p38, MDA, and NO.	Flavonoids	41-51	mitogen-activated protein kinase 14	Mus musculus	273-276
34951183-8	2021	Compared with the model group, the total flavonoids of Rhizoma Drynariae increased the expression of ERbeta and SOD in the hippocampus, down-regulated the expression of neuronal pro-apoptotic proteins, up-re-gulated the expression of anti-apoptotic proteins, and reduced p-p38/p38, MDA, and NO.	Flavonoids	41-51	mitogen-activated protein kinase 14	Mus musculus	277-280
34951183-10	2021	It has been proved that the total flavonoids of Drynariae Rhizoma obviously alleviate scopolamine-induced learning and memory impairments in mice, which may be achieved by regulating the neuronal apoptotic system and oxidative stress via the ER-p38 mitogen-activated protein kinase(ER-p38 MAPK) signaling pathway.	Flavonoids	34-44	mitogen-activated protein kinase 14	Mus musculus	245-248
34829584-0	2021	Antioxidant and Anti-Inflammatory Activity of Cynanchum acutum L. Isolated Flavonoids Using Experimentally Induced Type 2 Diabetes Mellitus: Biological and In Silico Investigation for NF-kappaB Pathway/miR-146a Expression Modulation.	Flavonoids	75-85	microRNA 146a	Rattus norvegicus	202-210
34951178-12	2021	Additionally, LRH flavonoids could improve the carbon clearance index in immunosuppressed mice, potentiate the activities of SOD and CAT and reduce MDA levels in the liver of aging mice induced by D-galactose, and effectively inhibit macrophage pyroptosis by decreasing the levels of caspase-1, IL-1beta, and IL-18.	Flavonoids	18-28	interleukin 1 alpha	Mus musculus	295-303
34951178-12	2021	Additionally, LRH flavonoids could improve the carbon clearance index in immunosuppressed mice, potentiate the activities of SOD and CAT and reduce MDA levels in the liver of aging mice induced by D-galactose, and effectively inhibit macrophage pyroptosis by decreasing the levels of caspase-1, IL-1beta, and IL-18.	Flavonoids	18-28	interleukin 18	Mus musculus	309-314
34829584-7	2021	Upregulation of miR-146a expression and downregulation of nuclear factor kappa B (NF-kappaB) expression were detected in the liver and adipose tissue of rats treated with the isolated flavonoids.	Flavonoids	184-194	microRNA 146a	Rattus norvegicus	16-24
34699735-9	2022	ClinicalTrials.gov Identifier: NCT01382056 Novelty:   Bean consumption by people with PAD alters the levels of certain metabolites in serum and urine   Different bean types (black, red kidney, pinto, navy) have unique flavonoid profiles   Metabolomics revealed potential diet-dug interactions as serum and/or urinary levels of metoprolol and metformin are modified by bean consumption.	Flavonoids	218-227	brain expressed associated with NEDD4 1	Homo sapiens	162-166
34745273-12	2021	Molecular docking shows that flavonoids such as quercetin have better binding to the target protein Akt1.	Flavonoids	29-39	AKT serine/threonine kinase 1	Homo sapiens	100-104
34770760-0	2021	AGSE: A Novel Grape Seed Extract Enriched for PP2A Activating Flavonoids That Combats Oxidative Stress and Promotes Skin Health.	Flavonoids	62-72	protein phosphatase 2 phosphatase activator	Homo sapiens	46-50
34699735-4	2022	Significant changes (P<0.05) in the profile and/or levels of 22 flavonoids present in bean extracts showed the potential importance of the mixture of beans used in this study.	Flavonoids	64-74	brain expressed associated with NEDD4 1	Homo sapiens	86-90
34500237-4	2021	The results showed that total flavonoids significantly increased body weight, routine blood indices, bone marrow DNA cells, and also markedly caused lymphocyte proliferation by increasing the percentages of CD4+ and CD8+.	Flavonoids	30-40	CD4 antigen	Mus musculus	207-210
34500237-5	2021	Using network pharmacology and metabolomics methods, the study identified 13 signal-related pathways regulated by total flavonoids including PI3K-Akt signaling pathway, Jak-STAT signaling pathway, Sphingolipid signaling pathway, and so on.	Flavonoids	120-130	thymoma viral proto-oncogene 1	Mus musculus	146-149
34500237-6	2021	Total flavonoids also reversed changes in serum cytokines IL-2, IL-6, and GM-CSF.	Flavonoids	6-16	interleukin 2	Mus musculus	58-62
34500237-6	2021	Total flavonoids also reversed changes in serum cytokines IL-2, IL-6, and GM-CSF.	Flavonoids	6-16	interleukin 6	Mus musculus	64-68
34500237-6	2021	Total flavonoids also reversed changes in serum cytokines IL-2, IL-6, and GM-CSF.	Flavonoids	6-16	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	74-80
34768743-0	2021	Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer.	Flavonoids	45-55	BCL2 apoptosis regulator	Homo sapiens	0-5
34768743-0	2021	Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer.	Flavonoids	45-55	tumor protein p53	Homo sapiens	20-23
34770760-7	2021	Via several fractionation and extraction steps we developed a novel grape seed extract called Activated Grape Seed Extract (AGSE), which is enriched for PP2A activating flavonoids that increase potency in preventing PP2A demethylation when compared to commercial GSE.	Flavonoids	169-179	protein phosphatase 2 phosphatase activator	Homo sapiens	153-157
34768743-8	2021	Flavonoids inhibit B-cell lymphoma 2 (Bcl-2) via the p53 signaling pathway, which is a significant apoptotic target in many cancer types, hence suppressing a major dysregulated pathway in cancer.	Flavonoids	0-10	BCL2 apoptosis regulator	Homo sapiens	38-43
34768743-8	2021	Flavonoids inhibit B-cell lymphoma 2 (Bcl-2) via the p53 signaling pathway, which is a significant apoptotic target in many cancer types, hence suppressing a major dysregulated pathway in cancer.	Flavonoids	0-10	tumor protein p53	Homo sapiens	53-56
34768743-9	2021	To date, there have been no studies reported which extensively highlight the role of flavonoids and especially the different classes of flavonoids in the modulation of Bcl-2 in the P53 signaling pathway.	Flavonoids	85-95	BCL2 apoptosis regulator	Homo sapiens	168-173
34768743-9	2021	To date, there have been no studies reported which extensively highlight the role of flavonoids and especially the different classes of flavonoids in the modulation of Bcl-2 in the P53 signaling pathway.	Flavonoids	85-95	tumor protein p53	Homo sapiens	181-184
34768743-9	2021	To date, there have been no studies reported which extensively highlight the role of flavonoids and especially the different classes of flavonoids in the modulation of Bcl-2 in the P53 signaling pathway.	Flavonoids	136-146	BCL2 apoptosis regulator	Homo sapiens	168-173
34768743-9	2021	To date, there have been no studies reported which extensively highlight the role of flavonoids and especially the different classes of flavonoids in the modulation of Bcl-2 in the P53 signaling pathway.	Flavonoids	136-146	tumor protein p53	Homo sapiens	181-184
34768743-10	2021	Herein, we discuss the modulation of Bcl-2 in the p53 signaling pathway by different classes of flavonoids and highlight different mechanisms through which this modulation can occur.	Flavonoids	96-106	BCL2 apoptosis regulator	Homo sapiens	37-42
34768743-10	2021	Herein, we discuss the modulation of Bcl-2 in the p53 signaling pathway by different classes of flavonoids and highlight different mechanisms through which this modulation can occur.	Flavonoids	96-106	tumor protein p53	Homo sapiens	50-53
34721993-1	2021	Dihydroflavonol 4-reductase (DFR), a key regulatory enzyme, participated in the biosynthesis of anthocyanins, proanthocyanidins and other flavonoids that essential for plant survival and human health.	Flavonoids	138-148	dihydroflavonol 4-reductase	Arabidopsis thaliana	29-32
34770760-7	2021	Via several fractionation and extraction steps we developed a novel grape seed extract called Activated Grape Seed Extract (AGSE), which is enriched for PP2A activating flavonoids that increase potency in preventing PP2A demethylation when compared to commercial GSE.	Flavonoids	169-179	protein phosphatase 2 phosphatase activator	Homo sapiens	216-220
34649540-10	2021	The results of reverse molecular docking suggest that in addition to triptolide, (-)-Epigallocatechin-3-gallate and resveratrol, the other 5 compounds (flavonoids) with similar structures may bind to the same position of STAT1 protein with different docking score.	Flavonoids	152-162	signal transducer and activator of transcription 1	Homo sapiens	221-226
34681895-5	2021	Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement.	Flavonoids	196-205	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
34509444-0	2021	Simultaneous determination of flavonoids and anthraquinones in honey by using SPE-CE-LIF.	Flavonoids	30-40	LIF interleukin 6 family cytokine	Homo sapiens	85-88
34681164-8	2021	Docking studies with the antiviral plant flavonoid Quercetin with NS3 indicated that Quercetin physically occluded the serine 137 phosphorylation site.	Flavonoids	41-50	KRAS proto-oncogene, GTPase	Homo sapiens	66-69
34685992-5	2021	We report the noncompetitive inhibition of the NS2B/NS3pro by the two bioflavonoids with half maximal inhibitory concentration (IC50) values <5 microM for HST and <70 microM for HSD.	Flavonoids	70-83	fibroblast growth factor 4	Homo sapiens	155-158
34606270-0	2021	Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).	Flavonoids	0-9	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	72-104
34606270-0	2021	Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).	Flavonoids	0-9	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	106-111
34606270-1	2021	We synthesize various substituted triazole-containing flavonoids and identify potent, nontoxic, and highly selective BCRP inhibitors.	Flavonoids	54-64	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	117-121
34681733-1	2021	Anthocyanin is a type of flavonoid pigment widely present in fruits and vegetables.	Flavonoids	25-34	DDB1 and CUL4 associated factor 7	Homo sapiens	0-11
34388484-1	2021	alpha-Glucosidase inhibition of 11 flavonoids, including myricetins, quercetins and catechins were studied through initial reaction velocity, IC50 value, inhibition kinetics, fluorescence quenching and molecular docking.	Flavonoids	35-45	sucrase-isomaltase	Homo sapiens	0-17
34721636-0	2021	Yunnan Black Tea Flavonoids Can Improve Cognitive Dysfunction in Septic Mice by Activating SIRT1.	Flavonoids	17-27	sirtuin 1	Mus musculus	91-96
34111536-13	2021	CONCLUSION: Our results reveal that flavonoids isolated from I. spuria L. (Hocka Hoona) and I. spuria L. (Calizona) appear to have a potential anti-inflammatory effect via inhibition of iNOS.	Flavonoids	36-46	nitric oxide synthase 2, inducible	Mus musculus	186-190
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	18-27	sucrase-isomaltase	Homo sapiens	96-113
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	18-27	sucrase-isomaltase	Homo sapiens	287-304
34350508-0	2021	Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer"s disease: flavonoids and phenols.	Flavonoids	77-87	thioredoxin interacting protein	Homo sapiens	0-31
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	82-92	sucrase-isomaltase	Homo sapiens	96-113
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	82-92	sucrase-isomaltase	Homo sapiens	287-304
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	323-333	sucrase-isomaltase	Homo sapiens	96-113
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	323-333	sucrase-isomaltase	Homo sapiens	287-304
34388484-8	2021	Notably, for same flavonoid sort, the constants that indicate binding affinity of flavonoids to alpha-glucosidase, including reciprocal of competitive inhibition constant, fluorescence quenching constant and binding energy followed same order as the inhibitory activity, indicating that alpha-glucosidase inhibition of the flavonoids resulted from binding interactions between them, and that the methods above can be combined reasonably to characterize flavonoid-enzyme binding interactions.	Flavonoids	453-462	sucrase-isomaltase	Homo sapiens	96-113
34350508-0	2021	Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer"s disease: flavonoids and phenols.	Flavonoids	77-87	thioredoxin interacting protein	Homo sapiens	33-38
34350508-4	2021	CB-dock was used to explore whether 21 natural flavonoids and phenols target TXNIP based on references.	Flavonoids	47-57	thioredoxin interacting protein	Homo sapiens	77-82
34350508-5	2021	Docking results showed that rutin, puerarin, baicalin, luteolin and quercetin are the most potent TXNIP inhibitors, and among them, rutin as the most effective flavonoid.	Flavonoids	160-169	thioredoxin interacting protein	Homo sapiens	98-103
34560101-5	2021	Here, using confocal microscopy and fluorescence recovery after photobleaching assays, we report that a natural antioxidant flavonoid compound myricetin slows LLPS of full-length human Tau, shifting the equilibrium phase boundary to a higher protein concentration.	Flavonoids	124-133	microtubule associated protein tau	Homo sapiens	185-188
34560101-6	2021	This natural flavonoid also significantly inhibits pathological phosphorylation and abnormal aggregation of Tau in neuronal cells, and blocks mitochondrial damage and apoptosis induced by Tau aggregation.	Flavonoids	13-22	microtubule associated protein tau	Homo sapiens	108-111
34560101-2	2021	A current therapeutic avenue for treating Alzheimer"s disease is aimed at inhibiting Tau accumulation with small molecules such as natural flavonoids.	Flavonoids	139-149	microtubule associated protein tau	Homo sapiens	85-88
34560101-6	2021	This natural flavonoid also significantly inhibits pathological phosphorylation and abnormal aggregation of Tau in neuronal cells, and blocks mitochondrial damage and apoptosis induced by Tau aggregation.	Flavonoids	13-22	microtubule associated protein tau	Homo sapiens	188-191
34560101-4	2021	However, it is unclear whether natural flavonoids modulate the formation of phase-separated Tau droplets or promote autophagy and Tau clearance.	Flavonoids	39-49	microtubule associated protein tau	Homo sapiens	92-95
34560101-8	2021	Consistently, this natural flavonoid inhibits mTOR pathway, activates ATG5-dependent Tau autophagy, and almost completely suppresses Tau toxicity in neuronal cells.	Flavonoids	27-36	mechanistic target of rapamycin kinase	Homo sapiens	46-50
34560101-8	2021	Consistently, this natural flavonoid inhibits mTOR pathway, activates ATG5-dependent Tau autophagy, and almost completely suppresses Tau toxicity in neuronal cells.	Flavonoids	27-36	autophagy related 5	Homo sapiens	70-74
34560101-8	2021	Consistently, this natural flavonoid inhibits mTOR pathway, activates ATG5-dependent Tau autophagy, and almost completely suppresses Tau toxicity in neuronal cells.	Flavonoids	27-36	microtubule associated protein tau	Homo sapiens	85-88
34560101-8	2021	Consistently, this natural flavonoid inhibits mTOR pathway, activates ATG5-dependent Tau autophagy, and almost completely suppresses Tau toxicity in neuronal cells.	Flavonoids	27-36	microtubule associated protein tau	Homo sapiens	133-136
34560101-9	2021	Collectively, these results demonstrate how LLPS and abnormal aggregation of Tau are inhibited by natural flavonoids, bridging the gap between Tau LLPS and aggregation in neuronal cells, and also establish that myricetin could act as an ATG5-dependent autophagic activator to ameliorate the pathogenesis of Alzheimer"s disease.	Flavonoids	106-116	microtubule associated protein tau	Homo sapiens	77-80
34560101-9	2021	Collectively, these results demonstrate how LLPS and abnormal aggregation of Tau are inhibited by natural flavonoids, bridging the gap between Tau LLPS and aggregation in neuronal cells, and also establish that myricetin could act as an ATG5-dependent autophagic activator to ameliorate the pathogenesis of Alzheimer"s disease.	Flavonoids	106-116	microtubule associated protein tau	Homo sapiens	143-146
34560101-9	2021	Collectively, these results demonstrate how LLPS and abnormal aggregation of Tau are inhibited by natural flavonoids, bridging the gap between Tau LLPS and aggregation in neuronal cells, and also establish that myricetin could act as an ATG5-dependent autophagic activator to ameliorate the pathogenesis of Alzheimer"s disease.	Flavonoids	106-116	autophagy related 5	Homo sapiens	237-241
34358729-6	2021	We assume that the deficiency in cryptochrome 1 under HIL irradiation disrupts the interaction between HY5 and HFR1 transcription factors and photoreceptors, which affects the transcription of light-induced genes, such as CAB1, PSY and PAL1 linked to carotenoid and flavonoid biosynthesis.	Flavonoids	266-275	PHE ammonia lyase 1	Arabidopsis thaliana	236-240
34817340-0	2021	Astragalin flavonoid inhibits proliferation in human lung carcinoma cells mediated via induction of caspase-dependent intrinsic pathway, ROS production, cell migration and invasion inhibition and targeting JAK/STAT signalling pathway.	Flavonoids	11-20	caspase 9	Homo sapiens	100-107
34419736-3	2021	It has reported that flavonoids have potential inhibitory activity on SARS-CoV-2 Mpro and anti-inflammatory properties.	Flavonoids	21-31	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	81-85
34592918-6	2021	Recently, quercetin-like flavonoid compounds with OH groups in their B-rings have been found to serve as activators of COX-2 by binding the POX site.	Flavonoids	25-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-124
34358729-6	2021	We assume that the deficiency in cryptochrome 1 under HIL irradiation disrupts the interaction between HY5 and HFR1 transcription factors and photoreceptors, which affects the transcription of light-induced genes, such as CAB1, PSY and PAL1 linked to carotenoid and flavonoid biosynthesis.	Flavonoids	266-275	cryptochrome 1	Arabidopsis thaliana	33-47
34358729-6	2021	We assume that the deficiency in cryptochrome 1 under HIL irradiation disrupts the interaction between HY5 and HFR1 transcription factors and photoreceptors, which affects the transcription of light-induced genes, such as CAB1, PSY and PAL1 linked to carotenoid and flavonoid biosynthesis.	Flavonoids	266-275	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	103-106
34358729-6	2021	We assume that the deficiency in cryptochrome 1 under HIL irradiation disrupts the interaction between HY5 and HFR1 transcription factors and photoreceptors, which affects the transcription of light-induced genes, such as CAB1, PSY and PAL1 linked to carotenoid and flavonoid biosynthesis.	Flavonoids	266-275	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	111-115
34817340-0	2021	Astragalin flavonoid inhibits proliferation in human lung carcinoma cells mediated via induction of caspase-dependent intrinsic pathway, ROS production, cell migration and invasion inhibition and targeting JAK/STAT signalling pathway.	Flavonoids	11-20	signal transducer and activator of transcription 3	Homo sapiens	210-214
34681197-8	2021	Stimulatory effect of the flavonoid on MUC1 cytoplasmic tail and extracellular domain in cell lysates and on MUC1 gene was revealed.	Flavonoids	26-35	mucin 1, cell surface associated	Homo sapiens	39-43
34681197-8	2021	Stimulatory effect of the flavonoid on MUC1 cytoplasmic tail and extracellular domain in cell lysates and on MUC1 gene was revealed.	Flavonoids	26-35	mucin 1, cell surface associated	Homo sapiens	109-113
34638666-5	2021	Among the propolis components, apigenin and apigenin-like flavonoids have potent protective effects against NO production and the mislocalization of CLDN1 induced by UVB.	Flavonoids	58-68	claudin 1	Homo sapiens	149-154
34641354-3	2021	Moreover, we demonstrated that the flavonoid quercetin downregulated the phosphorylated and active form of AKT.	Flavonoids	35-44	AKT serine/threonine kinase 1	Homo sapiens	107-110
34681197-9	2021	MUC1 release into the culture medium was inhibited by the flavonoid.	Flavonoids	58-67	mucin 1, cell surface associated	Homo sapiens	0-4
34681197-15	2021	Galectin-3 protein increased in cell lysates and decreased in culture supernatant by 60 and 120 muM flavonoid.	Flavonoids	100-109	galectin 3	Homo sapiens	0-10
34217736-0	2021	Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells.	Flavonoids	49-59	ATP binding cassette subfamily B member 1	Homo sapiens	90-104
34576199-1	2021	The Arabidopsis WD40 repeat protein TRANSPARENT TESTA GLABRA1 (TTG1) regulates cell fate determination, including trichome initiation and root hair formation, as well as secondary metabolism such as flavonoid biosynthesis and seed coat mucilage production.	Flavonoids	199-208	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	36-61
34576199-1	2021	The Arabidopsis WD40 repeat protein TRANSPARENT TESTA GLABRA1 (TTG1) regulates cell fate determination, including trichome initiation and root hair formation, as well as secondary metabolism such as flavonoid biosynthesis and seed coat mucilage production.	Flavonoids	199-208	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	63-67
34518767-0	2021	Bioflavonoid Galangin Suppresses Hypertrophic Scar Formation by the TGF-beta/Smad Signaling Pathway.	Flavonoids	0-12	transforming growth factor alpha	Homo sapiens	68-76
34518767-0	2021	Bioflavonoid Galangin Suppresses Hypertrophic Scar Formation by the TGF-beta/Smad Signaling Pathway.	Flavonoids	0-12	SMAD family member 7	Homo sapiens	77-81
34229245-5	2021	The flavonoids studied demonstrated relevant antiplatelet activity through the blocked of GPIIb/IIIa receptors, the suppression of the platelet activation, as well as the pro-aggregate effect of calcium ionophore.	Flavonoids	4-14	integrin subunit alpha 2b	Homo sapiens	90-95
34511152-3	2021	Flavonoids-induced biological activities are strongly influenced by their in-situ availability in the human GI tract, as well as the levels of which are modulated by interaction with the gut bacteria.	Flavonoids	0-10	G protein subunit alpha i1	Homo sapiens	108-110
34577000-0	2021	A Novel Approach to Unraveling the Apoptotic Potential of Rutin (Bioflavonoid) via Targeting Jab1 in Cervical Cancer Cells.	Flavonoids	65-77	COP9 signalosome subunit 5	Homo sapiens	93-97
34459191-0	2021	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	Flavonoids	63-73	macrophage migration inhibitory factor	Homo sapiens	83-121
34459191-0	2021	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	Flavonoids	63-73	macrophage migration inhibitory factor	Homo sapiens	123-126
34459191-1	2021	Dietary flavonoids are known to have anti-inflammatory and anticancer effects, but their influences on human macrophage migration inhibitory factor (MIF), a vital proinflammatory cytokine recognized as a therapeutic target for infectious diseases and cancers, have been rarely reported.	Flavonoids	8-18	macrophage migration inhibitory factor	Homo sapiens	109-147
34459191-1	2021	Dietary flavonoids are known to have anti-inflammatory and anticancer effects, but their influences on human macrophage migration inhibitory factor (MIF), a vital proinflammatory cytokine recognized as a therapeutic target for infectious diseases and cancers, have been rarely reported.	Flavonoids	8-18	macrophage migration inhibitory factor	Homo sapiens	149-152
34459191-8	2021	Our results elucidate the molecular mechanism of flavonoids acting on MIF and shed light on developing lead compounds against MIF-involved diseases.	Flavonoids	49-59	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	70-73
34459191-8	2021	Our results elucidate the molecular mechanism of flavonoids acting on MIF and shed light on developing lead compounds against MIF-involved diseases.	Flavonoids	49-59	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	126-129
34252860-4	2021	The best 3D-QSAR acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors pharmacophore hypotheses Hypo1 A and Hypo1 B were generated and validated by HypoGen program in Discovery Studio 2016 based on the training set of flavonoids, and then they were used as 3D query for screening the ZINC database.	Flavonoids	236-246	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-43
34252860-4	2021	The best 3D-QSAR acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors pharmacophore hypotheses Hypo1 A and Hypo1 B were generated and validated by HypoGen program in Discovery Studio 2016 based on the training set of flavonoids, and then they were used as 3D query for screening the ZINC database.	Flavonoids	236-246	butyrylcholinesterase	Homo sapiens	49-70
34252860-4	2021	The best 3D-QSAR acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors pharmacophore hypotheses Hypo1 A and Hypo1 B were generated and validated by HypoGen program in Discovery Studio 2016 based on the training set of flavonoids, and then they were used as 3D query for screening the ZINC database.	Flavonoids	236-246	butyrylcholinesterase	Homo sapiens	72-76
34217736-0	2021	Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells.	Flavonoids	49-59	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
34217736-0	2021	Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells.	Flavonoids	49-59	ATP binding cassette subfamily B member 1	Homo sapiens	167-171
34217736-1	2021	This study was aimed to investigate the inhibitory activity of flavonoids on P-glycoprotein (P-gp).	Flavonoids	63-73	ATP binding cassette subfamily B member 1	Homo sapiens	77-91
34217736-1	2021	This study was aimed to investigate the inhibitory activity of flavonoids on P-glycoprotein (P-gp).	Flavonoids	63-73	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
34217736-3	2021	The inhibition mechanism of selected flavonoids was further investigated by measuring the ATPase activity and expression level of P-gp.	Flavonoids	37-47	ATP binding cassette subfamily B member 1	Homo sapiens	130-134
34217736-6	2021	Whereas 5-OH, 5-OCH3, 6-OH, 7-OCH3, 3"-OH, and 4"-OH, are essential for inhibition of flavonoids on P-gp and reversing the resistance of Rho and DNR.	Flavonoids	86-96	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
34217736-7	2021	Eleven selected flavonoids significantly induced the basal P-gp-ATPase activity but much lower than that induced by verapamil.	Flavonoids	16-26	ATP binding cassette subfamily B member 1	Homo sapiens	59-63
34217736-9	2021	Six of eleven flavonoids significantly decreased P-gp expression, whereas three flavonoids slightly increased P-gp expression.	Flavonoids	14-24	ATP binding cassette subfamily B member 1	Homo sapiens	49-53
34217736-9	2021	Six of eleven flavonoids significantly decreased P-gp expression, whereas three flavonoids slightly increased P-gp expression.	Flavonoids	80-90	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
34217736-10	2021	These results provide valuable information that flavonoids can effectively reverse multidrug resistance of P-gp-mediated transport of nutraceutical and drugs by co-administration.	Flavonoids	48-58	ATP binding cassette subfamily B member 1	Homo sapiens	107-111
34333340-10	2021	Flavonoids acted by positively regulating MMPs 2, 8, 9 and 13, and the Ras/Raf/MEK/ERK, PI3K/Akt and NO pathways.	Flavonoids	0-10	matrix metallopeptidase 2	Homo sapiens	42-61
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Flavonoids	185-195	prostaglandin-endoperoxide synthase 1	Homo sapiens	57-79
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Flavonoids	185-195	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	81-86
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Flavonoids	185-195	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
34308490-9	2021	Compared with RsMYB1, the overexpression of RsMYB1-IRs in Arabidopsis pap1 mutant increased anthocyanin accumulation by > sevenfold and upregulated the expression of Arabidopsis flavonoid biosynthesis genes including AtTT8.	Flavonoids	178-187	phosphatidic acid phosphatase 1	Arabidopsis thaliana	70-74
34333340-10	2021	Flavonoids acted by positively regulating MMPs 2, 8, 9 and 13, and the Ras/Raf/MEK/ERK, PI3K/Akt and NO pathways.	Flavonoids	0-10	mitogen-activated protein kinase kinase 7	Homo sapiens	79-82
34333340-10	2021	Flavonoids acted by positively regulating MMPs 2, 8, 9 and 13, and the Ras/Raf/MEK/ERK, PI3K/Akt and NO pathways.	Flavonoids	0-10	mitogen-activated protein kinase 1	Homo sapiens	83-86
34333340-10	2021	Flavonoids acted by positively regulating MMPs 2, 8, 9 and 13, and the Ras/Raf/MEK/ERK, PI3K/Akt and NO pathways.	Flavonoids	0-10	AKT serine/threonine kinase 1	Homo sapiens	93-96
34502340-6	2021	Through in silico approach, selected flavonoids were docked into the active site of Mpro.	Flavonoids	37-47	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	84-88
34508344-9	2021	In combination with vitamin D, flavonoids possibly activate nuclear factor erythroid-derived-2-related factor 2 that downregulates ACE2 expression in cells.	Flavonoids	31-41	angiotensin converting enzyme 2	Homo sapiens	131-135
34502340-9	2021	The docking results showed that the selected flavonoids exhibited good poses in the binding domain of Mpro.	Flavonoids	45-55	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	102-106
34563040-6	2021	As a result, ERF1-F3 was abundant in total polyphenols and flavonoids contents with diverse active ingredients.	Flavonoids	59-69	eukaryotic translation termination factor 1	Mus musculus	13-17
34803452-0	2021	Targeting CoV-2 spike RBD and ACE-2 interaction with flavonoids of Anatolian propolis by in silico and in vitro studies in terms of possible COVID-19 therapeutics.	Flavonoids	53-63	angiotensin converting enzyme 2	Homo sapiens	30-35
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Flavonoids	21-30	interleukin 10	Mus musculus	121-126
34575637-11	2021	We further showed that the natural flavonoid luteolin is a potent inhibitor of the activation of both mast cells and microglia, but also blocks SARS-CoV-2 binding to its receptor angiotensin-converting enzyme 2 (ACE2).	Flavonoids	35-44	angiotensin converting enzyme 2	Homo sapiens	179-210
34575637-11	2021	We further showed that the natural flavonoid luteolin is a potent inhibitor of the activation of both mast cells and microglia, but also blocks SARS-CoV-2 binding to its receptor angiotensin-converting enzyme 2 (ACE2).	Flavonoids	35-44	angiotensin converting enzyme 2	Homo sapiens	212-216
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Flavonoids	21-30	interleukin 10	Mus musculus	137-142
34455975-0	2022	The Effects and Regulative Mechanism of Scutellaria Baicalensis Georgi Stems and Leaves Flavonoids in Promoting Neurogenesis and Improving Memory Impairment Mediated by BDNF-ERK-CREB Signal Pathway in Rats.	Flavonoids	88-98	brain-derived neurotrophic factor	Rattus norvegicus	169-173
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Flavonoids	21-30	interleukin 2	Mus musculus	143-147
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Flavonoids	231-240	interleukin 10	Mus musculus	121-126
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Flavonoids	231-240	interleukin 10	Mus musculus	137-142
34563040-10	2021	Total polyphenol and flavonoid contents in the media cultured with ER SDEO isolated fractions positively correlated with IL-10 (Th2) and IL-10/IL-2 (Th2/Th1) cytokine secretion ratios by splenocytes, indicating that polyphenol and flavonoid components in ER SDEO isolated fractions promote Th2-polarized and anti-inflammatory characteristics.	Flavonoids	231-240	interleukin 2	Mus musculus	143-147
34707441-4	2021	The use of natural products such as bioflavonoids possessing anti-degradative effect of vit.	Flavonoids	36-49	vitrin	Homo sapiens	88-91
34455966-0	2022	In-vitro Cytotoxicity and Aromatase Inhibitory Activity of Flavonoids: Synthesis, Molecular Docking and In-silico ADME Prediction.	Flavonoids	59-69	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	26-35
34455966-1	2022	BACKGROUND: Many natural and synthetic flavonoids have been studied and documented by inhibiting aromatase enzymes for their anti-cancer activity against breast carcinoma.	Flavonoids	39-49	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	97-106
34455966-3	2022	OBJECTIVE: Hence, a series of flavonoids have been synthesized and assessed for their in vitro cytotoxicity and aromatase inhibitory activity.	Flavonoids	30-40	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	112-121
34455975-0	2022	The Effects and Regulative Mechanism of Scutellaria Baicalensis Georgi Stems and Leaves Flavonoids in Promoting Neurogenesis and Improving Memory Impairment Mediated by BDNF-ERK-CREB Signal Pathway in Rats.	Flavonoids	88-98	Eph receptor B1	Rattus norvegicus	174-177
34455975-0	2022	The Effects and Regulative Mechanism of Scutellaria Baicalensis Georgi Stems and Leaves Flavonoids in Promoting Neurogenesis and Improving Memory Impairment Mediated by BDNF-ERK-CREB Signal Pathway in Rats.	Flavonoids	88-98	cAMP responsive element binding protein 1	Rattus norvegicus	178-182
34455975-3	2022	OBJECTIVE: To investigate the effects and regulative mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids in promoting neurogenesis and improving memory impairment mediated by BDNF-ERK-CREB signal pathway in rats.	Flavonoids	114-124	brain-derived neurotrophic factor	Rattus norvegicus	195-199
34455975-3	2022	OBJECTIVE: To investigate the effects and regulative mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids in promoting neurogenesis and improving memory impairment mediated by BDNF-ERK-CREB signal pathway in rats.	Flavonoids	114-124	Eph receptor B1	Rattus norvegicus	200-203
34455975-3	2022	OBJECTIVE: To investigate the effects and regulative mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids in promoting neurogenesis and improving memory impairment mediated by BDNF-ERK-CREB signal pathway in rats.	Flavonoids	114-124	cAMP responsive element binding protein 1	Rattus norvegicus	204-208
34169956-5	2021	The results showed that buckwheat hull flavonoids were potent in breaking AGEs in vitro, and they protected mice kidneys by regulating the renal AGE-RAGE pathway.	Flavonoids	39-49	advanced glycosylation end product-specific receptor	Mus musculus	149-153
34445714-8	2021	HY2 was then found to specifically mediate 215 differentially regulated proteins (DRPs), which, according to GO enrichment analysis, were mainly involved in ion homeostasis, flavonoid biosynthetic and metabolic pathways, hormone response (SA, JA, ABA, ethylene), the reactive oxygen species (ROS) metabolic pathway, photosynthesis, and detoxification pathways to respond to salt stress.	Flavonoids	174-183	phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2)	Arabidopsis thaliana	0-3
34369753-5	2021	Besides, the soluble phenolic fraction of B13 dose-dependently inhibited the proliferation of Caco-2 cells and the secretion of IL-1beta and NO in RAW264.7 macrophages, which might be attributed to its relatively high total phenolic (TPC), flavonoid (TFC), and proanthocyanidin content (TPAC) values and radical scavenging capacities.	Flavonoids	240-249	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	42-45
34269666-11	2021	In this review, the main natural compounds that are derived from alkaloids, flavonoids, terpene, and polyphenols as promising TNF-alpha inhibitors will be discussed.	Flavonoids	76-86	tumor necrosis factor	Homo sapiens	126-135
34373445-6	2021	The results reveal that flavonoid, glutathione, and lignin biosynthetic pathways may play important roles in protecting C. enshiensis from stress induced by Se.	Flavonoids	24-33	squalene epoxidase	Homo sapiens	157-159
34282832-0	2021	A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confers to suppression of acute myeloid leukemogenesis.	Flavonoids	36-45	histone deacetylase 9	Homo sapiens	50-54
34335282-0	2021	Corrigendum: Total Flavonoids of Rhizoma Drynariae Promotes Differentiation of Osteoblasts and Growth of Bone Graft in Induced Membrane Partly by Activating Wnt/beta-Catenin Signaling Pathway.	Flavonoids	19-29	catenin beta 1	Homo sapiens	161-173
34326858-8	2021	Weighted gene co-expression network analysis (WGCNA) revealed that AAE18, which is involved in activating auxin precursor 2,4-dichlorophenoxybutyric acid (2,4-DB) and two other auxin response genes, was highly co-expressed with flavonoid biosynthesis genes.	Flavonoids	228-237	acyl-activating enzyme 18	Arabidopsis thaliana	67-72
34326858-9	2021	With wounding treatment, the WT plants exhibited better growth performance than chalcone synthase (CHS), which was defective in flavonoid biosynthesis.	Flavonoids	128-137	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	99-102
34326858-7	2021	Moreover, MYC3 dominantly affected the gene expression of flavonoid biosynthesis.	Flavonoids	58-67	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	10-14
34236082-8	2021	Especially flavonoid compounds extracted from edible fruits possess potential antiviral activity against a wide array of viruses like HIV-1, HSV-1 and 2, HCV, INF, dengue, yellow fever, NSV, and Zika virus infection.	Flavonoids	11-20	hsv-1 and 2	None	141-152
34356309-5	2021	In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-beta1 signaling and increase TGF-beta1 production in the central nervous system as well as cognitive function.	Flavonoids	131-141	transforming growth factor beta 1	Homo sapiens	197-206
34356309-5	2021	In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-beta1 signaling and increase TGF-beta1 production in the central nervous system as well as cognitive function.	Flavonoids	131-141	transforming growth factor beta 1	Homo sapiens	230-239
34208379-5	2021	This review summarizes in vitro and in vivo studies providing data related to the effects of flavonoids and flavonoid-rich foods on the modulation of the insulin route during T2D and obesity.	Flavonoids	93-103	insulin	Homo sapiens	154-161
34188068-9	2021	Flavonoids from YIV-906 were responsible for modulating IDO activity and potentiating IFNg action in M1-like macrophage polarization.	Flavonoids	0-10	indoleamine 2,3-dioxygenase 1	Homo sapiens	56-59
34188068-9	2021	Flavonoids from YIV-906 were responsible for modulating IDO activity and potentiating IFNg action in M1-like macrophage polarization.	Flavonoids	0-10	interferon gamma	Homo sapiens	86-90
34106722-0	2021	Bovine beta-Lactoglobulin Covalent Modification by Flavonoids: Effect on the Allergenicity and Human Intestinal Microbiota.	Flavonoids	51-61	beta-lactoglobulin	Bos taurus	7-25
34106722-1	2021	The present study aims to investigate the structure of covalent conjugates of bovine beta-lactoglobulin (BLG) and flavonoids (luteolin, myricetin, and hyperoside), and their effect on the allergenicity and human intestinal microbiota.	Flavonoids	114-124	beta-lactoglobulin	Bos taurus	85-103
34106722-1	2021	The present study aims to investigate the structure of covalent conjugates of bovine beta-lactoglobulin (BLG) and flavonoids (luteolin, myricetin, and hyperoside), and their effect on the allergenicity and human intestinal microbiota.	Flavonoids	114-124	beta-lactoglobulin	Bos taurus	105-108
34106722-2	2021	Covalent modification of amino acids in BLG by flavonoids was confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and o-phthaldialdehyde assay.	Flavonoids	47-57	beta-lactoglobulin	Bos taurus	40-43
34106722-5	2021	Meanwhile, covalent modification of BLG with these flavonoids can alter the diversity of human intestinal microbiota and the community abundance at phylum, family, and genus levels.	Flavonoids	51-61	beta-lactoglobulin	Bos taurus	36-39
34106722-6	2021	The results revealed that covalent modification of BLG with flavonoids alters human intestinal microbiota, might result in the reduction of allergenicity, which could provide information for confirming the relationship between food allergy and the intestinal microbial ecosystem.	Flavonoids	60-70	beta-lactoglobulin	Bos taurus	51-54
34220446-3	2021	We previously reported that oral administration of the flavonoid (-)-epicatechin (EC) reduced Amyloid-beta (Abeta) plaque pathology in APP/PS1 transgenic mice.	Flavonoids	55-64	presenilin 1	Mus musculus	139-142
34208928-3	2021	The natural flavonoid quercetin 1 has been recently reported to be a potent Mpro inhibitor in vitro, and we explored the effect produced by the introduction of organoselenium functionalities in this scaffold.	Flavonoids	12-21	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	76-80
34257824-5	2021	Dietary intake of flavonoids, a C15 group of polyphenols, is known to inhibit cancer progression and assist DNA repair through p53-mediated mechanisms in human cells via their antioxidant activities.	Flavonoids	18-28	tumor protein p53	Homo sapiens	127-130
34249001-4	2021	In this mini review, we highlight recent progress in our understanding of the modulation of immune responses by the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor whose activity can be regulated by diverse molecules including flavonoids.	Flavonoids	252-262	aryl hydrocarbon receptor	Homo sapiens	116-141
34249001-4	2021	In this mini review, we highlight recent progress in our understanding of the modulation of immune responses by the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor whose activity can be regulated by diverse molecules including flavonoids.	Flavonoids	252-262	aryl hydrocarbon receptor	Homo sapiens	143-146
34249001-5	2021	We focus on the role of AhR in integrating signals from flavonoids to modulate inflammatory responses using in vitro and experimental animal models.	Flavonoids	56-66	aryl hydrocarbon receptor	Homo sapiens	24-27
34201713-3	2021	In this study, we targeted the genes of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, and two transcriptional factors, MYBL2 and ANAC032, negatively regulating anthocyanin biosynthesis in Arabidopsis.	Flavonoids	87-96	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	40-57
34201713-3	2021	In this study, we targeted the genes of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, and two transcriptional factors, MYBL2 and ANAC032, negatively regulating anthocyanin biosynthesis in Arabidopsis.	Flavonoids	87-96	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	59-62
34205659-9	2021	Herein, we review the relationship between GLP-1 and food factors, especially dietary peptides and flavonoids.	Flavonoids	99-109	glucagon	Homo sapiens	43-48
34931981-9	2021	These natural compounds include numerous flavonoids which help in preventing glucose absorption by preventing the absorption of alpha-amylase and alpha-glucosidase.	Flavonoids	41-51	sucrase-isomaltase	Homo sapiens	146-163
34177989-0	2021	LaPT2 Gene Encodes a Flavonoid Prenyltransferase in White Lupin.	Flavonoids	21-30	5'-nucleotidase, cytosolic IIIA	Homo sapiens	58-63
34177989-2	2021	In the present study, we identified a prenyltransferase (PT) gene, named LaPT2, in white lupin (Lupinus albus), which shows a high identity and close relationship with the other known PT genes involved in flavonoid prenylation in planta.	Flavonoids	205-214	5'-nucleotidase, cytosolic IIIA	Homo sapiens	89-94
34208379-5	2021	This review summarizes in vitro and in vivo studies providing data related to the effects of flavonoids and flavonoid-rich foods on the modulation of the insulin route during T2D and obesity.	Flavonoids	108-117	insulin	Homo sapiens	154-161
34107799-1	2021	The current research used a virtual screening method to study 57 isolated phytochemicals (alkaloids, phytosterols, and flavonoids) against the SARS-CoV-2 main protease (Mpro).	Flavonoids	119-129	main protease	None	154-167
34177989-8	2021	Our study demonstrated that LaPT2 from white lupin is responsible for the biosynthesis of prenylated flavonoids, in particular flavonols, which could be utilized as phytoalexin for plant defense and bioactive flavonoid compounds for human health.	Flavonoids	101-111	5'-nucleotidase, cytosolic IIIA	Homo sapiens	45-50
34177989-8	2021	Our study demonstrated that LaPT2 from white lupin is responsible for the biosynthesis of prenylated flavonoids, in particular flavonols, which could be utilized as phytoalexin for plant defense and bioactive flavonoid compounds for human health.	Flavonoids	209-218	5'-nucleotidase, cytosolic IIIA	Homo sapiens	45-50
34107799-1	2021	The current research used a virtual screening method to study 57 isolated phytochemicals (alkaloids, phytosterols, and flavonoids) against the SARS-CoV-2 main protease (Mpro).	Flavonoids	119-129	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	169-173
34060409-0	2021	On the inhibition of cytochrome P450 3A4 by structurally diversified flavonoids.	Flavonoids	69-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-40
34074127-2	2021	The expression of HO-1 is triggered by the Nrf2-Keap1 signaling pathway which responds to exogenous stress signals and dietary constituents such as flavonoids and glucosinolates or reactive metabolic intermediates like 4-hydroxynonenal.	Flavonoids	148-158	heme oxygenase 1	Mus musculus	18-22
34074127-2	2021	The expression of HO-1 is triggered by the Nrf2-Keap1 signaling pathway which responds to exogenous stress signals and dietary constituents such as flavonoids and glucosinolates or reactive metabolic intermediates like 4-hydroxynonenal.	Flavonoids	148-158	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
34074127-2	2021	The expression of HO-1 is triggered by the Nrf2-Keap1 signaling pathway which responds to exogenous stress signals and dietary constituents such as flavonoids and glucosinolates or reactive metabolic intermediates like 4-hydroxynonenal.	Flavonoids	148-158	kelch-like ECH-associated protein 1	Mus musculus	48-53
34149918-0	2021	Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling.	Flavonoids	0-9	AKT serine/threonine kinase 1	Homo sapiens	102-105
34149918-0	2021	Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling.	Flavonoids	0-9	matrix metallopeptidase 2	Homo sapiens	110-117
34098806-5	2021	First, the state-of-the-art concerning inflammatory stress and mitochondrial dysfunction is reviewed and a comprehensive overview of recent in vitro studies investigating the impact of flavonoids on cellular stress, induced by tumor necrosis factor alpha, lipopolysaccharide and mitochondrial stressors, is given.	Flavonoids	185-195	tumor necrosis factor	Homo sapiens	227-254
34199888-8	2021	Recent evidence suggests that certain flavonoids could help stabilize the correctly folded conformation of the visual photoreceptor protein rhodopsin and offset the deleterious effect of retinitis pigmentosa mutations.	Flavonoids	38-48	rhodopsin	Homo sapiens	140-149
34199888-9	2021	In this regard, certain polyphenols, like the flavonoids mentioned before, have been shown to improve the stability, expression, regeneration and folding of rhodopsin mutants in experimental in vitro studies.	Flavonoids	46-56	rhodopsin	Homo sapiens	157-166
33595948-8	2021	Interestingly, the effects of HCA on the growth and death of HepG2 cells were inhibited by culturing with CH223191, an antagonist of aryl hydrocarbon receptor (AHR), suggesting that the flavonoid effects are, at least partly, mediated by activation of AHR signaling.	Flavonoids	186-195	aryl hydrocarbon receptor	Homo sapiens	252-255
34060409-8	2021	A kinetic threshold for further assessment of the drug-drug interactions underlying the time-dependent inhibition of CYP3A4 by flavonoids is explored.Communicated by Ramaswamy H. Sarma.	Flavonoids	127-137	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	117-123
34071978-0	2021	Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer"s Disease: Beneficial Effects of Flavonoids for Neuroprotection.	Flavonoids	113-123	brain derived neurotrophic factor	Homo sapiens	0-33
34254227-1	2021	Quercetin is one of the major flavonoids and it appears to have cytotoxic effects on various cancer cells through regulating the apoptosis pathway genes such as BAX and BCL2.	Flavonoids	30-40	BCL2 associated X, apoptosis regulator	Homo sapiens	161-164
34071978-5	2021	Further, we discuss a potential usefulness of small compounds, including flavonoids, which can stimulate BDNF-related signaling as a BDNF-targeting therapy.	Flavonoids	73-83	brain derived neurotrophic factor	Homo sapiens	105-109
34071978-5	2021	Further, we discuss a potential usefulness of small compounds, including flavonoids, which can stimulate BDNF-related signaling as a BDNF-targeting therapy.	Flavonoids	73-83	brain derived neurotrophic factor	Homo sapiens	133-137
34068211-6	2021	Furthermore, MET treatment enhances osmoregulation and photosynthetic efficiency, and increases the concentration of other important antioxidants such as phenolic compounds, flavonoids, polyamines (PAs), and carotenoid compounds.	Flavonoids	174-184	SAFB like transcription modulator	Homo sapiens	13-16
34122101-0	2021	Total Flavonoids of Rhizoma Drynariae Promotes Differentiation of Osteoblasts and Growth of Bone Graft in Induced Membrane Partly by Activating Wnt/beta-Catenin Signaling Pathway.	Flavonoids	6-16	catenin beta 1	Rattus norvegicus	148-160
34079466-4	2021	Purpose: We aimed to investigate the flavonoid extract (TF) and AM"s effects on NLRP3 inflammasome in vitro and their preventive effects on gout in vivo.	Flavonoids	37-46	NLR family, pyrin domain containing 3	Mus musculus	80-85
34064664-11	2021	In conclusion, both flavonoids afford similar protective effects against Ang II-induced cardiomyocyte hypertrophy, but they differently modulate MAPK pathway.	Flavonoids	20-30	angiotensinogen	Rattus norvegicus	73-79
34068281-5	2021	The pro-autophagic activity of seven flavonoid aglycons correlated perfectly with their ability to inhibit NQO2 activity, and flavones such as apigenin and luteolin showed the strongest activity in all assays.	Flavonoids	37-46	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	107-111
34068281-10	2021	These findings imply that NQO2 works as a flavone receptor mediating autophagy and may contribute to other hepatic effects of flavonoids.	Flavonoids	126-136	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	26-30
34470563-3	2021	Coloured grains of major and minor cereals are due to accumulation of secondary metabolites like carotenoids and flavonoids such as anthocyanin, proanthocyanin, phlobaphenes in pericarp, aleurone, lemma, testa or seed coat of grains.	Flavonoids	113-123	DDB1 and CUL4 associated factor 7	Homo sapiens	132-143
34193695-1	2021	Flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (AChE) inhibitory activity for treating Alzheimer"s disease (AD).	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-104
34521318-1	2021	Helianthus Annuus L. (HAL) is composed of flavonoids and polysaccharides.	Flavonoids	42-52	histidine ammonia lyase	Mus musculus	22-25
34193695-1	2021	Flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (AChE) inhibitory activity for treating Alzheimer"s disease (AD).	Flavonoids	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
34193695-2	2021	In present study, in line with our interests in flavonoid derivatives as AChE inhibitors, a four-dimensional quantitative structure-activity relationship (4D-QSAR) molecular model was proposed.	Flavonoids	48-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77
34193695-7	2021	The molecular docking analysis was also carried out to understand exceedingly the interactions between flavonoids and the AChE targets, which was in good agreement with the 4D-QSAR model.	Flavonoids	103-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	122-126
34193695-8	2021	Based on the information provided by the 4D-QSAR model and molecular docking analysis, the idea for optimizing the structures of flavonoids as AChE inhibitors was put forward which maybe provide theoretical guidance for the research and development of new AChE inhibitors.	Flavonoids	129-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-147
34193695-8	2021	Based on the information provided by the 4D-QSAR model and molecular docking analysis, the idea for optimizing the structures of flavonoids as AChE inhibitors was put forward which maybe provide theoretical guidance for the research and development of new AChE inhibitors.	Flavonoids	129-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	256-260
34348607-9	2021	The flavonoids exhibit their anticancer activity via different molecular pathways, including PI3K/Akt/mTOR.	Flavonoids	4-14	AKT serine/threonine kinase 1	Homo sapiens	98-101
34348607-9	2021	The flavonoids exhibit their anticancer activity via different molecular pathways, including PI3K/Akt/mTOR.	Flavonoids	4-14	mechanistic target of rapamycin kinase	Homo sapiens	102-106
34348607-10	2021	In the current piece of paper, our focus is to underpin the action of the above-mentioned flavonoids against different cancers, mainly covering in-vitro data, especially through PI3K/Akt/mTOR targeting.	Flavonoids	90-100	AKT serine/threonine kinase 1	Homo sapiens	183-186
34348607-10	2021	In the current piece of paper, our focus is to underpin the action of the above-mentioned flavonoids against different cancers, mainly covering in-vitro data, especially through PI3K/Akt/mTOR targeting.	Flavonoids	90-100	mechanistic target of rapamycin kinase	Homo sapiens	187-191
35279499-0	2022	Multispectroscopic and computational evaluation of the binding of flavonoids with bovine serum albumin in the presence of Cu2.	Flavonoids	66-76	albumin	Homo sapiens	89-102
35421650-1	2022	Bovine beta-casein (beta-CN) has attracted increasingly interest as biocompatible nanocarrier for hydrophobic flavonoid due to its self-assembly ability to form micelles.	Flavonoids	110-119	casein beta	Bos taurus	7-18
35279499-1	2022	Bovine serum albumin (BSA) has the potential application of establishing a delivery system for flavonoids.	Flavonoids	95-105	albumin	Homo sapiens	7-20
35489289-7	2022	In efforts to identify pharmacological agents that target this pathway, we found that fisetin, a natural flavonoid, is an ULK1 inhibitor that decreases type I IFN-induced dACE2 expression.	Flavonoids	105-114	Acetylcholine esterase	Drosophila melanogaster	171-176
35589023-0	2022	The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-kappaB and MAPK signaling pathways.	Flavonoids	13-22	notch 1	Mus musculus	108-114
35589023-0	2022	The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-kappaB and MAPK signaling pathways.	Flavonoids	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
35357518-6	2022	The findings of this review confirm that polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins are capable of modulating FOXO1 and associated signaling pathways, and they are potential therapeutic agents for NAFLD and related complications.	Flavonoids	54-64	forkhead box O1	Homo sapiens	132-137
35351576-0	2022	The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice.	Flavonoids	51-61	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	85-91
35351576-0	2022	The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice.	Flavonoids	51-61	glucosidase beta 2	Mus musculus	113-122
35594703-3	2022	Green tea flavonoids --especially epigallocatechin gallate (EGCG)-- are potent ABCB1 modulators.	Flavonoids	10-20	ATP binding cassette subfamily B member 1	Homo sapiens	79-84
35621148-0	2022	Effects of the total flavonoid extracts and the monomers of Daphne genkwa on CYP2C8 activity.	Flavonoids	21-30	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	77-83
35331878-1	2022	flavonoids protect against pathological cardiac hypertrophy by inhibiting the Raf/MEK/ERK pathway: In vivo and in vitro studies.	Flavonoids	0-10	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	78-81
35331878-1	2022	flavonoids protect against pathological cardiac hypertrophy by inhibiting the Raf/MEK/ERK pathway: In vivo and in vitro studies.	Flavonoids	0-10	Eph receptor B1	Rattus norvegicus	86-89
35621148-2	2022	This study aimed to assess the effects of total flavonoid extracts (TFDG) and the monomers of Daphne genkwa on the CYP2C8 activity in vitro and in vivo.2.	Flavonoids	48-57	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	115-121
35610002-5	2022	Some flavonoid compounds of Citrus fruits act on Immun-oregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for entry.	Flavonoids	5-14	angiotensin converting enzyme 2	Homo sapiens	78-109
35587203-5	2022	Flavonoids, a class of polyphenolic natural products, have been found experimentally to inhibit IAPP aggregate formation.	Flavonoids	0-10	islet amyloid polypeptide	Homo sapiens	96-100
35593082-6	2022	The results of alpha-glucosidase inhibitory activity of 21 isolated compounds and molecular docking studies also indicated these flavonoids had potent alpha-glucosidase inhibitory activity.	Flavonoids	129-139	sucrase-isomaltase	Homo sapiens	151-168
35612780-4	2022	In view of this, the aim of the present study was to investigate the association among protein aggregation, autophagy and BAG2 levels in cultured cells from hippocampus and locus coeruleus as well as in SH-SY5Y cell line upon different protein aggregation scenarios induced by rotenone, which is a flavonoid used as pesticide and triggers neurodegeneration.	Flavonoids	298-307	BAG cochaperone 2	Homo sapiens	122-126
35411358-4	2022	It turns out that flavonoids are the largest group of phenolic-type Nrf2-activators, followed by nonflavonoids and phenolic acids.	Flavonoids	18-28	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
35609756-0	2022	Anoectochilus roxburghii flavonoids extract ameliorated the memory decline and reduced neuron apoptosis via modulating SIRT1 signaling pathway in senescent mice.	Flavonoids	25-35	sirtuin 1	Mus musculus	119-124
35412073-2	2022	Among the prominent polyphenols contained in citrus fruits and primarily in grapefruit, the flavonoid naringenin is known to be a blocker of the human ether-a-go-go related gene (hERG) potassium channel.	Flavonoids	92-101	ETS transcription factor ERG	Homo sapiens	179-183
35612681-0	2022	Regulation of interleukin-6 and matrix metalloproteinases syntheses by bioflavonoids and photobiomodulation in human gingival fibroblasts.	Flavonoids	71-84	interleukin 6	Homo sapiens	14-27
35612681-11	2022	In conclusion, TNF-alpha up-regulated IL-6 and MMPs, while bioflavonoids and PBM down-regulated MMP-2 and MMP-9 syntheses; GSE also decreased IL-6 synthesis, demonstrating the individual promising potential of these therapies for ulceration management.	Flavonoids	59-72	matrix metallopeptidase 2	Homo sapiens	96-101
35612681-11	2022	In conclusion, TNF-alpha up-regulated IL-6 and MMPs, while bioflavonoids and PBM down-regulated MMP-2 and MMP-9 syntheses; GSE also decreased IL-6 synthesis, demonstrating the individual promising potential of these therapies for ulceration management.	Flavonoids	59-72	matrix metallopeptidase 9	Homo sapiens	106-111
35604596-0	2022	Ajwa date flavonoids mitigate neutrophil migration and interferon-gamma-induced renal injury by ultraviolet C radiation in rats.	Flavonoids	10-20	interferon gamma	Rattus norvegicus	55-71
35630816-0	2022	Functional Characterization of Flavanone 3-Hydroxylase (F3H) and Its Role in Anthocyanin and Flavonoid Biosynthesis in Mulberry.	Flavonoids	93-102	flavanone 3-hydroxylase	Nicotiana tabacum	31-54
35630816-0	2022	Functional Characterization of Flavanone 3-Hydroxylase (F3H) and Its Role in Anthocyanin and Flavonoid Biosynthesis in Mulberry.	Flavonoids	93-102	flavanone 3-hydroxylase	Nicotiana tabacum	56-59
35630816-12	2022	Down-regulation of F3H expression levels resulted in co-expression of the genes involved in anthocyanin biosynthesis and a significant decrease in anthocyanin content, but the change in total flavonoid content was subtle.	Flavonoids	192-201	flavanone 3-hydroxylase	Nicotiana tabacum	19-22
35596149-11	2022	The transcriptome analysis indicated down-regulation in the expression of PHENYLALANINE AMMONIA LYASE (PAL), the LEUCOANTHOCYANIDIN OXIDISING enzyme gene LDOX, and the MYB-RELATED PROTEIN Hv1 (MYB-Hv1), a transcription factor coding gene, which is presumably involved in the regulation of flavonoid biosynthesis, in the leaves of a selected StGI.04-repressed line.	Flavonoids	289-298	phenylalanine ammonia-lyase	Solanum tuberosum	103-106
35630703-0	2022	Co-Application of Statin and Flavonoids as an Effective Strategy to Reduce the Activity of Voltage-Gated Potassium Channels Kv1.3 and Induce Apoptosis in Human Leukemic T Cell Line Jurkat.	Flavonoids	29-39	potassium voltage-gated channel subfamily A member 3	Homo sapiens	124-129
35532753-7	2022	We suggest that PVX infection decreases AtPAP1 expression, leading to the downregulation of phenylpropanoid and flavonoid biosynthesis in transgenic plants.	Flavonoids	112-121	phosphatidic acid phosphatase 1	Arabidopsis thaliana	40-46
35630703-2	2022	Lipophilic non-toxic organic inhibitors of Kv1.3 channels, such as statins and flavonoids, may have clinical applications in supporting the therapy of some cancer diseases, such as breast, pancreas, and lung cancer; melanoma; or chronic lymphocytic leukemia.	Flavonoids	79-89	potassium voltage-gated channel subfamily A member 3	Homo sapiens	43-48
35628133-5	2022	In this study, we used exogenous gene-specific dsRNA to downregulate the gene of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, in Arabidopsis.	Flavonoids	128-137	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	81-98
35634373-9	2022	Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4.	Flavonoids	110-120	dipeptidyl peptidase 4	Homo sapiens	420-425
35634373-0	2022	Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism.	Flavonoids	40-50	dipeptidyl peptidase 4	Homo sapiens	14-36
35634373-1	2022	With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, and isoliquiritigenin showed higher inhibitory activities in a concentration-dependent manner.	Flavonoids	74-84	dipeptidyl peptidase 4	Homo sapiens	93-115
35634373-1	2022	With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, and isoliquiritigenin showed higher inhibitory activities in a concentration-dependent manner.	Flavonoids	74-84	dipeptidyl peptidase 4	Homo sapiens	117-122
35634373-1	2022	With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate the interaction mechanisms between them, a pannel of 70 structurally diverse flavonoids was used to evaluate their inhibitory activities against DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, and isoliquiritigenin showed higher inhibitory activities in a concentration-dependent manner.	Flavonoids	74-84	dipeptidyl peptidase 4	Homo sapiens	283-288
35634373-2	2022	Structure-activity relationship analysis revealed that introducing hydroxyl groups to C3", C4", and C6 of the flavonoid structure was beneficial to improving the inhibitory efficacy against DPP-4, whereas the hydroxylation at position 3 of ring C in the flavonoid structure was unfavorable for the inhibition.	Flavonoids	110-119	dipeptidyl peptidase 4	Homo sapiens	190-195
35634373-2	2022	Structure-activity relationship analysis revealed that introducing hydroxyl groups to C3", C4", and C6 of the flavonoid structure was beneficial to improving the inhibitory efficacy against DPP-4, whereas the hydroxylation at position 3 of ring C in the flavonoid structure was unfavorable for the inhibition.	Flavonoids	254-263	dipeptidyl peptidase 4	Homo sapiens	190-195
35634373-3	2022	Besides, the methylation of the hydroxyl groups at C3", C4", and C7 of the flavonoid structure tended to lower the inhibitory activity against DPP-4, and the 2,3-double bond and 4-carbonyl group on ring C of the flavonoid structure was essential for the inhibition.	Flavonoids	75-84	dipeptidyl peptidase 4	Homo sapiens	143-148
35634373-3	2022	Besides, the methylation of the hydroxyl groups at C3", C4", and C7 of the flavonoid structure tended to lower the inhibitory activity against DPP-4, and the 2,3-double bond and 4-carbonyl group on ring C of the flavonoid structure was essential for the inhibition.	Flavonoids	212-221	dipeptidyl peptidase 4	Homo sapiens	143-148
35634373-6	2022	Moreover, the fluorescence quenching analysis indicated that all the five flavonoid compounds could effectively quench the intrinsic fluorescence of DPP-4 by spontaneously binding with it to form an unstable complex.	Flavonoids	74-83	dipeptidyl peptidase 4	Homo sapiens	149-154
35634373-7	2022	Hydrogen bonds and van der Waals were the predominant forces to maintain the complex of myricetin with DPP-4, and electrostatic forces might play an important role in stabilizing the complexes of the remaining four flavonoids with DPP-4.	Flavonoids	215-225	dipeptidyl peptidase 4	Homo sapiens	231-236
35634373-8	2022	The binding of the tested flavonoids to DPP-4 could also induce the conformation change of DPP-4 and thus led to inhibition on the enzyme.	Flavonoids	26-36	dipeptidyl peptidase 4	Homo sapiens	40-45
35634373-8	2022	The binding of the tested flavonoids to DPP-4 could also induce the conformation change of DPP-4 and thus led to inhibition on the enzyme.	Flavonoids	26-36	dipeptidyl peptidase 4	Homo sapiens	91-96
35634373-9	2022	Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4.	Flavonoids	110-120	dipeptidyl peptidase 4	Homo sapiens	82-87
35634373-9	2022	Molecular docking simulation further ascertained the binding interactions between DPP-4 and the selected five flavonoids, among which hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin inserted into the active site cavity of DPP-4 and interacted with the key amino acid residues of the active site, whereas the binding site of myricetin was located in a minor cavity close to the active pockets of DPP-4.	Flavonoids	110-120	dipeptidyl peptidase 4	Homo sapiens	247-252
35625617-0	2022	Flavonoid Biosynthesis Genes in Triticum aestivum L.: Methylation Patterns in Cis-Regulatory Regions of the Duplicated CHI and F3H Genes.	Flavonoids	0-9	flavanone 3-dioxygenase 2	Triticum aestivum	127-130
35625617-2	2022	The biosynthesis of flavonoids occurs through the activity of several enzymes, including chalcone isomerase (CHI) and flavanone 3-hydroxylase (F3H).	Flavonoids	20-30	flavanone 3-dioxygenase 2	Triticum aestivum	118-141
35625617-2	2022	The biosynthesis of flavonoids occurs through the activity of several enzymes, including chalcone isomerase (CHI) and flavanone 3-hydroxylase (F3H).	Flavonoids	20-30	flavanone 3-dioxygenase 2	Triticum aestivum	143-146
35628133-5	2022	In this study, we used exogenous gene-specific dsRNA to downregulate the gene of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, in Arabidopsis.	Flavonoids	128-137	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	100-103
35586809-1	2022	Objectives: Lotus leaf is rich in flavonoids, and this study is aimed at examining the inhibitory effect of lotus leaf-enriched flavonoid extract (LLEFE) on HT-29 colon cancer cells through phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) expression regulation.	Flavonoids	128-137	protein tyrosine kinase 2 beta	Homo sapiens	220-236
35586809-1	2022	Objectives: Lotus leaf is rich in flavonoids, and this study is aimed at examining the inhibitory effect of lotus leaf-enriched flavonoid extract (LLEFE) on HT-29 colon cancer cells through phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) expression regulation.	Flavonoids	128-137	AKT serine/threonine kinase 1	Homo sapiens	243-246
35586809-9	2022	Conclusion: Lotus leaves contain functional flavonoids that inhibit the proliferation of HT-29 colon cancer cells and regulate the expression of PI3K/Akt through five important chemicals.	Flavonoids	44-54	AKT serine/threonine kinase 1	Homo sapiens	150-153
35241486-0	2022	Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by the Popular Flavonoids Baicalein, Baicalin and Hyperoside is responsible for Herbs (Shuang-huang-lian) -Induced Jaundice.	Flavonoids	77-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
35527362-12	2022	DG-SDH formulated at a ratio of 3:2 (DG-SDH (3:2)) produced the highest content of polysaccharides, polyphenols, and flavonoids.	Flavonoids	117-127	serine dehydratase	Homo sapiens	3-6
35527362-12	2022	DG-SDH formulated at a ratio of 3:2 (DG-SDH (3:2)) produced the highest content of polysaccharides, polyphenols, and flavonoids.	Flavonoids	117-127	serine dehydratase	Homo sapiens	40-43
35427872-10	2022	In contrast, honey"s anti-inflammatory actions and flavonoids induce anti-inflammatory and antioxidant pathways by inducing NRF2 target genes, including HO-1 and PRDX1.	Flavonoids	51-61	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
35427872-10	2022	In contrast, honey"s anti-inflammatory actions and flavonoids induce anti-inflammatory and antioxidant pathways by inducing NRF2 target genes, including HO-1 and PRDX1.	Flavonoids	51-61	heme oxygenase 1	Homo sapiens	153-157
35427872-10	2022	In contrast, honey"s anti-inflammatory actions and flavonoids induce anti-inflammatory and antioxidant pathways by inducing NRF2 target genes, including HO-1 and PRDX1.	Flavonoids	51-61	peroxiredoxin 1	Homo sapiens	162-167
35241486-10	2022	As a commonly used herbal products rich in flavonoids, Shuang-huang-lian injections (SHL), easily lead to symptoms of liver injury (e.g., jaundice) owing to significant inhibition of hUGT1A1-mediated bilirubin glucuronidation by its flavonoid components (i.e., baicalein, baicalin, hyperoside).	Flavonoids	233-242	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	183-190
35241486-8	2022	Collectively, some naturally occurring flavonoids (BAI, BA and HYP) in SHL have been identified as the inhibitors against hUGT1A1-mediated bilirubin glucuronidation, which well-explains the bilirubin-related ADRs or malady triggered by SHL in clinical settings.	Flavonoids	39-49	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	122-129
35241486-10	2022	As a commonly used herbal products rich in flavonoids, Shuang-huang-lian injections (SHL), easily lead to symptoms of liver injury (e.g., jaundice) owing to significant inhibition of hUGT1A1-mediated bilirubin glucuronidation by its flavonoid components (i.e., baicalein, baicalin, hyperoside).	Flavonoids	43-53	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	183-190
35202652-0	2022	The naturally occurring flavonoid nobiletin reverses methotrexate resistance via inhibition of P-glycoprotein synthesis.	Flavonoids	24-33	phosphoglycolate phosphatase	Mus musculus	95-109
35351314-0	2022	Overexpression of histone demethylase gene SlJMJ524 from tomato confers Cd tolerance by regulating metal transport-related protein genes and flavonoid content in Arabidopsis.	Flavonoids	141-150	JmjC-domain protein JMJ524	Solanum lycopersicum	43-51
35566218-5	2022	The results show that A. senticosus flavonoids can significantly downregulate the levels of ROS and MDA in H2O2-treated RAW 264.7 cells and increase the levels of CAT, SOD, and GPx.	Flavonoids	36-46	catalase	Mus musculus	163-166
35566218-5	2022	The results show that A. senticosus flavonoids can significantly downregulate the levels of ROS and MDA in H2O2-treated RAW 264.7 cells and increase the levels of CAT, SOD, and GPx.	Flavonoids	36-46	peroxiredoxin 6 pseudogene 2	Mus musculus	177-180
35566218-7	2022	ELISA experiments confirmed that A. senticosus flavonoids could reduce the level of MDA in the mouse serum and increase the levels of SOD, CAT, and GPx.	Flavonoids	47-57	catalase	Mus musculus	139-142
35566218-7	2022	ELISA experiments confirmed that A. senticosus flavonoids could reduce the level of MDA in the mouse serum and increase the levels of SOD, CAT, and GPx.	Flavonoids	47-57	peroxiredoxin 6 pseudogene 2	Mus musculus	148-151
35477414-0	2022	A molecular dynamics perspective into estrogen receptor inhibition by selective flavonoids as alternative therapeutic options.	Flavonoids	80-90	estrogen receptor 1	Homo sapiens	38-55
35477414-4	2022	This study aimed to identity flavonoid ERalpha inhibitors and provide insights into the mechanism of inhibition using computational techniques.	Flavonoids	29-38	estrogen receptor 1	Homo sapiens	39-46
35477414-5	2022	The Molecular Mechanics/Generalized Born Surface Area calculations revealed that quercetrin, hesperidin, epigallocatechin 3-gallate and kaempferol 7-O-glucoside out of 14 flavonoids had higher binding affinity for ERalpha than OHT.	Flavonoids	171-181	estrogen receptor 1	Homo sapiens	214-221
35477414-7	2022	The results of this study provide imperative information that supports the use of flavonoids in the inhibition of ERalpha to prevent or ameliorate the consequential adverse effects associated with zearalenone exposure.Communicated by Ramaswamy H. Sarma.	Flavonoids	82-92	estrogen receptor 1	Homo sapiens	114-121
35466876-8	2022	Our literature survey covering the years of 2006-2021 pointed out that flavonoids frequently interact with SIRT1 and SIRT3 followed by SIRT6.	Flavonoids	71-81	sirtuin 1	Homo sapiens	107-112
35466876-8	2022	Our literature survey covering the years of 2006-2021 pointed out that flavonoids frequently interact with SIRT1 and SIRT3 followed by SIRT6.	Flavonoids	71-81	sirtuin 3	Homo sapiens	117-122
35380573-1	2022	Studies examining the association between flavonoid intake and measures of insulin resistance and beta-cell dysfunction, as markers of type 2 diabetes (T2DM) across the adult lifespan, may provide insights into how flavonoids influence T2DM risk.	Flavonoids	42-51	insulin	Homo sapiens	75-82
35380573-1	2022	Studies examining the association between flavonoid intake and measures of insulin resistance and beta-cell dysfunction, as markers of type 2 diabetes (T2DM) across the adult lifespan, may provide insights into how flavonoids influence T2DM risk.	Flavonoids	215-225	insulin	Homo sapiens	75-82
35380573-2	2022	This study examined the cross-sectional associations between flavonoid intakes, from dietary sources other than tea, and biomarkers of glucose tolerance and insulin sensitivity in adults aged 25 years and older participating in the Australian diabetes, obesity and lifestyle (AusDiab) study.	Flavonoids	61-70	insulin	Homo sapiens	157-164
35380573-7	2022	Cross-sectionally, significant beneficial associations were observed for intakes of total flavonoids and the flavan-3-ol-monomer, proanthocyanidin, flavonol and anthocyanidin subclasses with measures of glucose tolerance and insulin sensitivity (P < 0.05 for all), except fasting plasma glucose.	Flavonoids	90-100	insulin	Homo sapiens	225-232
35380573-10	2022	This study provides some evidence that consuming flavonoid-rich foods may be protective against T2DM through mechanisms related to glucose tolerance and insulin sensitivity.	Flavonoids	49-58	insulin	Homo sapiens	153-160
35366855-14	2022	Hesperidin, a compound present in the Citrus extracts, was identified as the main flavonoid, which can serve as a cost-effective potent inhibitor of NS3 protease, and could be developed as a drug for antiviral therapy against HCV genotype 3a.	Flavonoids	82-91	KRAS proto-oncogene, GTPase	Homo sapiens	149-152
35182887-0	2022	Target identification of anti-diabetic and anti-obesity flavonoid derivative (Fla-CN).	Flavonoids	56-65	4-hydroxyphenylpyruvic acid dioxygenase	Mus musculus	78-81
35182887-1	2022	Fla-CN is a flavonoid derivative with anti-diabetic and anti-obesity effects; however, its biological targets are still unknown.	Flavonoids	12-21	4-hydroxyphenylpyruvic acid dioxygenase	Mus musculus	0-3
35227839-3	2022	Therefore in this study inclusion complexes of Q and R with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were formulated to improve the aqueous solubility, antiproliferative efficacy and also antioxidant activity of the flavonoids.	Flavonoids	220-230	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	96-103
35563427-0	2022	Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1beta Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells.	Flavonoids	0-9	interleukin 1 alpha	Mus musculus	119-127
35218268-3	2022	RNA sequencing analysis of an Arabidopsis null allele for chalcone synthase (CHS), which catalyzes the first step in flavonoid metabolism, has uncovered evidence that these compounds influence the expression of genes associated with the plant circadian clock.	Flavonoids	117-126	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	58-75
35218268-3	2022	RNA sequencing analysis of an Arabidopsis null allele for chalcone synthase (CHS), which catalyzes the first step in flavonoid metabolism, has uncovered evidence that these compounds influence the expression of genes associated with the plant circadian clock.	Flavonoids	117-126	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	77-80
35377153-0	2022	Flavonoids as Protein Disulfide Isomerase Inhibitors: Key Molecular and Structural Features for the Interaction.	Flavonoids	0-10	prolyl 4-hydroxylase subunit beta	Homo sapiens	14-41
35377153-11	2022	These results provide new insight into the molecular mechanism by which flavonoids block PDI activity.	Flavonoids	72-82	prolyl 4-hydroxylase subunit beta	Homo sapiens	89-92
35495138-12	2022	The members of CHIs interacted with chalcone synthase (CHS), flavonol synthase/flavanone 3-hydroxylase (FLS) and naringenin, and 2-oxoglutarate 3-dioxygenase (F3H) to form heterodimers, which might together play a regulatory role and participate in the flavonoid pathway.	Flavonoids	253-262	flavonol synthase/flavanone 3-hydroxylase	Citrus sinensis	61-102
35262427-4	2022	AREAS COVERED: In order to overcome issues such as poor pharmacokinetic properties or efficacy, frequently associated with natural compounds, different GSK-3beta inhibitors belonging to alkaloid or flavonoid classes have been subjected to structural modifications in order to obtain more potent and safer compounds.	Flavonoids	198-207	glycogen synthase kinase 3 alpha	Homo sapiens	152-161
35527825-2	2022	We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK i, on a set of 75 structurally different compounds including oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids.	Flavonoids	203-213	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
35452382-13	2022	In addition, serum levels of estradiol and SHBG were positively associated with Eubacterium ramulus, a flavonoid-degrading bacterium.	Flavonoids	103-112	sex hormone binding globulin	Homo sapiens	43-47
35193745-5	2022	The transcriptional regulators belonging to the MYB and bHLH family transcription factors are well documented as the direct regulators of the structural genes associated with flavonoid biosynthesis.	Flavonoids	175-184	MYB proto-oncogene, transcription factor	Homo sapiens	48-51
35576701-0	2022	Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors.	Flavonoids	76-86	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	14-43
35576701-2	2022	In this study, we investigated the structure-activity relationship of the inhibition of fatty acid-oxidizing CYP by flavonoids.	Flavonoids	116-126	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	109-112
35165923-0	2022	Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice.	Flavonoids	0-10	rhodopsin	Mus musculus	54-63
35363375-5	2022	The total phenolic and flavonoid content increased from 56.20-253.90 mg GAE/100 g and 47.41-202.90 mg QE/100 g in the functional pasta.	Flavonoids	23-32	solute carrier family 45 member 1	Homo sapiens	129-134
35363375-9	2022	Fourier Transform Infrared (FTIR) spectroscopy further confirmed the presence of phenols, flavonoids and chlorophyll in WGP incorporated pasta.	Flavonoids	90-100	solute carrier family 45 member 1	Homo sapiens	137-142
35229382-4	2022	In this paper, myricetin was selected from among several flavonoid compounds as an effective PAR1 antagonist.	Flavonoids	57-66	Prader Willi/Angelman region RNA 1	Homo sapiens	93-97
35408611-6	2022	Under first objective, we conducted a quantitative structure-activity relationship analysis of flavonoids with PTP1B that revealed the strongest correlation (R2 = 93.25%) between the number of aromatic bonds (naro) and inhibitory concentrations (IC50) of PTP1B.	Flavonoids	95-105	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	111-116
35408611-6	2022	Under first objective, we conducted a quantitative structure-activity relationship analysis of flavonoids with PTP1B that revealed the strongest correlation (R2 = 93.25%) between the number of aromatic bonds (naro) and inhibitory concentrations (IC50) of PTP1B.	Flavonoids	95-105	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	255-260
35175047-2	2022	In this study, the interaction between quercetin (a major flavonoid in the human diet) and bovine serum albumin (BSA) was investigated in the absence and presence of free Cu(II).	Flavonoids	58-67	albumin	Homo sapiens	98-111
35408512-8	2022	In conclusion, this study suggests that the flavonoids, phenolic acids and polysaccharides from chrysanthemum stem and leaf extracts can improve inflammatory bowel disease of zebrafish by regulating the expressions of IL-1beta, IL-8 and MMP9.	Flavonoids	44-54	chemokine (C-X-C motif) ligand 8a	Danio rerio	228-232
35408512-8	2022	In conclusion, this study suggests that the flavonoids, phenolic acids and polysaccharides from chrysanthemum stem and leaf extracts can improve inflammatory bowel disease of zebrafish by regulating the expressions of IL-1beta, IL-8 and MMP9.	Flavonoids	44-54	matrix metallopeptidase 9	Danio rerio	237-241
35408435-4	2022	The antibacterial and antioxidant bioactivities of the total flavonoids of Abrus cantoniensis (ATF) have been widely reported in national and international journals, but there are fewer studies on their anti-inflammatory effects.	Flavonoids	61-71	glial cell line derived neurotrophic factor	Mus musculus	95-98
35408453-2	2022	A functional tea seed flavonoid, kaempferol-3-O-(2-O-beta-d-xylopyranosyl-6-O-alpha-L-rhanmopyranosyl)-beta-d-glucopyranoside (KXRG), was isolated from tea seed dregs.	Flavonoids	22-31	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	13-16
35407065-2	2022	Spirulina incorporation led to development of green color pasta with nutritional and functional fortification resulting in increase in its protein, total phenols, flavonoids, iron and calcium content by up to 77.47%, 76.62%, 162.88%, 296.99% and 57.27%, respectively, without causing detrimental changes to the textural and sensory attributes.	Flavonoids	163-173	solute carrier family 45 member 1	Homo sapiens	58-63
35453307-5	2022	The results showed that low-dose flavonoids slightly promoted the proliferation of breast cancer cells under normal growth via gradually reducing accumulated oxidative products and demonstrated a synergistic effect with reductants NAC or VC.	Flavonoids	33-43	synuclein alpha	Homo sapiens	231-234
35453307-7	2022	However, high-dose flavonoids markedly triggered the cell death via oxidative stress as evidenced by upregulated ROS, MDA and downregulated SOD activity that could be partly rescued by NAC pretreatment, which was also confirmed by antioxidative gene expression levels.	Flavonoids	19-29	synuclein alpha	Homo sapiens	185-188
35453307-9	2022	Transcriptomic analysis of apigenin and quercetin uncovered that high-dose flavonoids activated TNF-alpha signaling, as verified through detecting inflammatory gene levels in breast cancer cells and RAW 264.7 macrophages.	Flavonoids	75-85	tumor necrosis factor	Homo sapiens	96-105
35453307-10	2022	Moreover, we identified that BRCA1 overexpression effectively attenuated such oxidative stress, inflammation and inhibited ATP synthesis induced by LPS or high dose of flavonoids possibly through repairing DNA damage, revealing an indispensable biological function of BRCA1 in resisting oxidative damage and inflammatory stimulation caused by exogenous factors.	Flavonoids	168-178	BRCA1 DNA repair associated	Homo sapiens	29-34
35453307-10	2022	Moreover, we identified that BRCA1 overexpression effectively attenuated such oxidative stress, inflammation and inhibited ATP synthesis induced by LPS or high dose of flavonoids possibly through repairing DNA damage, revealing an indispensable biological function of BRCA1 in resisting oxidative damage and inflammatory stimulation caused by exogenous factors.	Flavonoids	168-178	BRCA1 DNA repair associated	Homo sapiens	268-273
35335387-7	2022	This flavonoid also reduced cytokine production and Toll-like receptor 4 expression, inhibited nuclear factor-kappaB and mitogen-activated protein kinase cascades, and alleviated immune cell infiltration.	Flavonoids	5-14	toll-like receptor 4	Mus musculus	52-72
35371117-6	2022	Among them, certain flavonoids, with high content, were also identified for the first time in JHK, such as tricetin, catechin, hesperidin, ncyanidin-3-O-sambubioside, astragalin, procyanidin B2/B3/C1, apigenin-5-O-glucoside, etc.	Flavonoids	20-30	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	191-199
35183811-0	2022	Evaluation of the binding performance of flavonoids to estrogen receptor alpha by Autodock, Autodock Vina and Surflex-Dock.	Flavonoids	41-51	estrogen receptor 1	Homo sapiens	55-78
35183811-4	2022	In this study, we systematically compared the performance of three popular docking programs, Autodock, Autodock Vina, and Surflex-Dock for a series of structurally similar weekly binding flavonoids (22) binding to the estrogen receptor alpha (ERalpha).	Flavonoids	187-197	estrogen receptor 1	Homo sapiens	218-241
35183811-4	2022	In this study, we systematically compared the performance of three popular docking programs, Autodock, Autodock Vina, and Surflex-Dock for a series of structurally similar weekly binding flavonoids (22) binding to the estrogen receptor alpha (ERalpha).	Flavonoids	187-197	estrogen receptor 1	Homo sapiens	243-250
35183811-5	2022	For these flavonoids-ERalpha interactions, Surflex-Dock showed higher accuracy than Autodock and Autodock Vina.	Flavonoids	10-20	estrogen receptor 1	Homo sapiens	21-28
35183811-7	2022	Moreover, the selection of initial receptor structure is critical as it influences the docking conformations of flavonoids-ERalpha complexes.	Flavonoids	112-122	estrogen receptor 1	Homo sapiens	123-130
35183811-9	2022	In addition, binding interaction analysis revealed that 8 residues, including Ala350, Glu353, Leu387, Arg394, Phe404, Gly521, His524, and Leu525, are the key residues in ERalpha-flavonoids complexes.	Flavonoids	178-188	estrogen receptor 1	Homo sapiens	170-177
35183811-10	2022	This work provides reference for assessing molecular interactions between ERalpha and flavonoid-like chemicals and provides instructive information for other environmental chemicals.	Flavonoids	86-95	estrogen receptor 1	Homo sapiens	74-81
35591928-5	2022	An in vitro study showed that the transcriptional levels of ERF1B-like TF for hexokinase inhibitor and sucrose treatments were upregulated, being respectively 28.1- and 30.2-fold higher than in the control, suggesting that ERF1B-like TFs participate in the sugar-induced regulation of flavonoid biosynthesis.	Flavonoids	285-294	hexokinase	Saccharomyces cerevisiae S288C	78-88
35245426-4	2022	Pre-treatment with 20 microM of 1 and 2 suppressed MMP-9 expression in LPS-mediated THP-1 cells, indicating that the characteristic flavonoids in C. edulis could be potential anti-angiogenics for cancer prevention.	Flavonoids	132-142	matrix metallopeptidase 9	Homo sapiens	51-56
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	25-34	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	77-83
35121551-0	2022	Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo.	Flavonoids	46-55	nuclear receptor subfamily 4, group A, member 1	Mus musculus	89-94
35121551-0	2022	Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo.	Flavonoids	46-55	nuclear receptor subfamily 4, group A, member 1	Mus musculus	127-132
35121551-5	2022	These data suggest that the Nur77-targeting flavonoid derivatives can be particularly useful for further pharmaceutical development for the treatment of inflammatory diseases such as ALI.	Flavonoids	44-53	nuclear receptor subfamily 4, group A, member 1	Mus musculus	28-33
35134627-3	2022	Natural flavonoids are useful compounds reported to have therapeutic effects in diseases involving IL-4.	Flavonoids	8-18	interleukin 4	Homo sapiens	99-103
35362177-6	2022	Finally, flavonoid accumulation decreased in max2-1 roots, supporting a role for MAX2 in regulating both strigolactone and flavonoid biosynthesis.	Flavonoids	123-132	RNI-like superfamily protein	Arabidopsis thaliana	81-85
35279613-0	2022	Extracts of Ginkgo flavonoids and ginkgolides improve cerebral ischaemia-reperfusion injury through the PI3K/Akt/Nrf2 signalling pathway and multicomponent in vivo processes.	Flavonoids	19-29	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
35279613-0	2022	Extracts of Ginkgo flavonoids and ginkgolides improve cerebral ischaemia-reperfusion injury through the PI3K/Akt/Nrf2 signalling pathway and multicomponent in vivo processes.	Flavonoids	19-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	113-117
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	25-34	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	85-88
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	25-34	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	106-112
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	25-34	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	114-117
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	25-34	RNI-like superfamily protein	Arabidopsis thaliana	140-144
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	25-34	RNI-like superfamily protein	Arabidopsis thaliana	195-199
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	214-223	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	85-88
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	214-223	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	114-117
35362177-4	2022	The transcription of key flavonoid biosynthetic genes, including TRANSPARENT TESTA4 (TT4) and TRANSPARENT TESTA5 (TT5) was downregulated in max2 roots and seedlings, indicating that the proposed MAX2 regulation of flavonoid biosynthesis has a widespread effect.	Flavonoids	214-223	RNI-like superfamily protein	Arabidopsis thaliana	140-144
35362177-5	2022	We found an enrichment of BRI1-EMS-SUPPRESSOR 1 (BES1) targets among genes specifically altered in the max2 mutant, reflecting that the regulation of flavonoid biosynthesis likely occurs through the MAX2 degradation of BES1, a key brassinosteroid-related transcription factor.	Flavonoids	150-159	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	26-47
35362177-5	2022	We found an enrichment of BRI1-EMS-SUPPRESSOR 1 (BES1) targets among genes specifically altered in the max2 mutant, reflecting that the regulation of flavonoid biosynthesis likely occurs through the MAX2 degradation of BES1, a key brassinosteroid-related transcription factor.	Flavonoids	150-159	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	49-53
35362177-5	2022	We found an enrichment of BRI1-EMS-SUPPRESSOR 1 (BES1) targets among genes specifically altered in the max2 mutant, reflecting that the regulation of flavonoid biosynthesis likely occurs through the MAX2 degradation of BES1, a key brassinosteroid-related transcription factor.	Flavonoids	150-159	RNI-like superfamily protein	Arabidopsis thaliana	103-107
35362177-5	2022	We found an enrichment of BRI1-EMS-SUPPRESSOR 1 (BES1) targets among genes specifically altered in the max2 mutant, reflecting that the regulation of flavonoid biosynthesis likely occurs through the MAX2 degradation of BES1, a key brassinosteroid-related transcription factor.	Flavonoids	150-159	RNI-like superfamily protein	Arabidopsis thaliana	199-203
35362177-5	2022	We found an enrichment of BRI1-EMS-SUPPRESSOR 1 (BES1) targets among genes specifically altered in the max2 mutant, reflecting that the regulation of flavonoid biosynthesis likely occurs through the MAX2 degradation of BES1, a key brassinosteroid-related transcription factor.	Flavonoids	150-159	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	219-223
35362177-6	2022	Finally, flavonoid accumulation decreased in max2-1 roots, supporting a role for MAX2 in regulating both strigolactone and flavonoid biosynthesis.	Flavonoids	9-18	RNI-like superfamily protein	Arabidopsis thaliana	45-49
35362177-6	2022	Finally, flavonoid accumulation decreased in max2-1 roots, supporting a role for MAX2 in regulating both strigolactone and flavonoid biosynthesis.	Flavonoids	9-18	RNI-like superfamily protein	Arabidopsis thaliana	81-85
35362177-6	2022	Finally, flavonoid accumulation decreased in max2-1 roots, supporting a role for MAX2 in regulating both strigolactone and flavonoid biosynthesis.	Flavonoids	123-132	RNI-like superfamily protein	Arabidopsis thaliana	45-49
35104489-7	2022	Nutraceuticals belonging to the chemical category polyphenols, alkaloids, terpenoids, flavonoids, tannins have the potential to combat the NF-kappaB pathway.	Flavonoids	86-96	nuclear factor kappa B subunit 1	Homo sapiens	139-148
35217709-3	2022	Although recovery was similar with UAE and MAE, 3 min MAE with 80% ethanol and 80% methanol produced the highest yields of total phenolic content (TPC), total flavonoid content (TFC) and phenolic acids.	Flavonoids	159-168	solute carrier family 6 member 1	Homo sapiens	54-57
35250385-6	2022	Polyphenols and flavonoids, secondary metabolites in CCE that regulate the NF-kappaB pathway, may be responsible for its anti-inflammatory activity.	Flavonoids	16-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
35282447-1	2022	Our previous study demonstrated that the bone protective actions of herbal medicine Rhizoma Drynariae (Gusuibu, RD) were mainly mediated by flavonoid phytoestrogens via estrogen receptors, raising concerns about the safety of using RD as it may induce estrogen-like risk-benefit profile and interact with other ER ligands, such as selective estrogen receptor modulators (SERMs), when coadministered.	Flavonoids	140-149	estrogen receptor 1	Rattus norvegicus	341-358
35194046-6	2022	We uncover that quercetin, a natural plant flavonoid, increases PANX1 protein levels in RMS by inducing re-expression of a 5" leader-containing PANX1 transcript variant that is efficiently translated.	Flavonoids	43-52	pannexin 1	Homo sapiens	64-69
35194046-6	2022	We uncover that quercetin, a natural plant flavonoid, increases PANX1 protein levels in RMS by inducing re-expression of a 5" leader-containing PANX1 transcript variant that is efficiently translated.	Flavonoids	43-52	pannexin 1	Homo sapiens	144-149
35157175-0	2022	Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2.	Flavonoids	26-36	angiotensin converting enzyme 2	Homo sapiens	82-86
35112564-0	2022	Transport and Interactions of Co-incubated Bi-functional Flavonoids through Inhibiting the Function of P-Glycoprotein (P-gp) Using KB/Multidrug-Resistant (MDR) Cells and Rat Everted Gut Sacs.	Flavonoids	57-67	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	103-117
35112564-0	2022	Transport and Interactions of Co-incubated Bi-functional Flavonoids through Inhibiting the Function of P-Glycoprotein (P-gp) Using KB/Multidrug-Resistant (MDR) Cells and Rat Everted Gut Sacs.	Flavonoids	57-67	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	119-123
35112564-1	2022	This study aims to evaluate the interaction of flavonoid-flavonoid by inhibiting the function of P-glycoprotein (P-gp).	Flavonoids	47-56	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	97-111
35112564-1	2022	This study aims to evaluate the interaction of flavonoid-flavonoid by inhibiting the function of P-glycoprotein (P-gp).	Flavonoids	47-56	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	113-117
35112564-1	2022	This study aims to evaluate the interaction of flavonoid-flavonoid by inhibiting the function of P-glycoprotein (P-gp).	Flavonoids	57-66	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	97-111
35112564-1	2022	This study aims to evaluate the interaction of flavonoid-flavonoid by inhibiting the function of P-glycoprotein (P-gp).	Flavonoids	57-66	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	113-117
35112564-8	2022	Docking explained the inhibition of flavonoids on P-gp by competitively binding to the ATP site.	Flavonoids	36-46	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	50-54
35209110-5	2022	Consistently, in primary murine macrophages, both flavonoids decreased the inflammatory response by lowering LPS-induced IL1 and IL6 expression.	Flavonoids	50-60	interleukin 1 complex	Mus musculus	121-124
35209110-5	2022	Consistently, in primary murine macrophages, both flavonoids decreased the inflammatory response by lowering LPS-induced IL1 and IL6 expression.	Flavonoids	50-60	interleukin 6	Mus musculus	129-132
35237153-1	2022	Many natural flavonoids can activate nuclear factor erythroid 2-related factor 2 (Nrf2), which is pivotal for alleviating various diseases related to inflammation and oxidative stress, including pleurisy.	Flavonoids	13-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	37-80
35237153-1	2022	Many natural flavonoids can activate nuclear factor erythroid 2-related factor 2 (Nrf2), which is pivotal for alleviating various diseases related to inflammation and oxidative stress, including pleurisy.	Flavonoids	13-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
35045245-6	2022	Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor kappaB (NF-kappaB)/IkappaB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction.	Flavonoids	33-43	NFE2 like bZIP transcription factor 2	Homo sapiens	257-261
35045245-6	2022	Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor kappaB (NF-kappaB)/IkappaB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction.	Flavonoids	33-43	kelch like ECH associated protein 1	Homo sapiens	262-267
35045245-6	2022	Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor kappaB (NF-kappaB)/IkappaB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction.	Flavonoids	33-43	nuclear factor kappa B subunit 1	Homo sapiens	329-338
35045245-6	2022	Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor kappaB (NF-kappaB)/IkappaB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction.	Flavonoids	33-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	408-413
35045245-6	2022	Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor kappaB (NF-kappaB)/IkappaB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction.	Flavonoids	33-43	heat shock transcription factor 1	Homo sapiens	414-418
35045245-6	2022	Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor kappaB (NF-kappaB)/IkappaB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction.	Flavonoids	33-43	phosphatase and tensin homolog	Homo sapiens	443-447
35045245-6	2022	Research findings indicated that flavonoids significantly exhibit various redox-based therapeutic responses against several diseases such as inflammatory, neurodegenerative, cardiovascular, and hepatic diseases and various types of cancer by activating the Nrf2/Keap1 transcription system, suppressing the nuclear factor kappaB (NF-kappaB)/IkappaB kinase inflammatory pathway, abrogating the function of the Hsp90/Hsf1 complex, inhibiting the PTEN/PI3K/Akt pathway, and preventing mitochondrial dysfunction.	Flavonoids	33-43	AKT serine/threonine kinase 1	Homo sapiens	453-456
35259610-0	2022	Flavonoids from Scutellaria barbata D. Don exert antitumor activity in colorectal cancer through inhibited autophagy and promoted apoptosis via ATF4/sestrin2 pathway.	Flavonoids	0-10	activating transcription factor 4	Homo sapiens	144-148
35259610-0	2022	Flavonoids from Scutellaria barbata D. Don exert antitumor activity in colorectal cancer through inhibited autophagy and promoted apoptosis via ATF4/sestrin2 pathway.	Flavonoids	0-10	sestrin 2	Homo sapiens	149-157
35215447-0	2022	Bamboo Leaf Flavonoids Suppress Oxidative Stress-Induced Senescence of HaCaT Cells and UVB-Induced Photoaging of Mice through p38 MAPK and Autophagy Signaling.	Flavonoids	12-22	mitogen-activated protein kinase 14	Mus musculus	126-134
35015798-0	2022	Inhibitory activity of flavonoids against human sucrase-isomaltase (alpha-glucosidase) activity in a Caco-2/TC7 cellular model.	Flavonoids	23-33	sucrase-isomaltase	Homo sapiens	68-85
35145607-4	2022	This study evaluated the flavonoid isoquercetin (Q3G) as an antitumor compound related to colon cancer vascularization and regulation of VASH1 and 2.	Flavonoids	25-34	vasohibin 1	Mus musculus	137-148
35207127-2	2022	In plants, alkaloids, phytohormones, ion chelators, and flavonoids have been reported to be the substrates of MATE transporters.	Flavonoids	56-66	aluminum-activated citrate transporter	Glycine max	110-114
35164411-0	2022	Flavonoids: Antiplatelet Effect as Inhibitors of COX-1.	Flavonoids	0-10	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	49-54
35015798-4	2022	The present study evaluates the inhibitory activity of a selected group of flavonoids against human sucrase-isomaltase (SI), the alpha-glucosidase found in Caco-2/TC7 cells.	Flavonoids	75-85	sucrase-isomaltase	Homo sapiens	129-146
34999176-0	2022	Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation.	Flavonoids	19-28	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
35215307-0	2022	Exploring the Natural Compounds in Flavonoids for Their Potential Inhibition of Cancer Therapeutic Target MEK1 Using Computational Methods.	Flavonoids	35-45	mitogen-activated protein kinase kinase 1	Homo sapiens	106-110
35215307-4	2022	This study aims to explore flavonoids for their inhibition ability, targeting MEK1 using virtual screening, molecular docking, ADMET prediction, and molecular dynamics (MD) simulations.	Flavonoids	27-37	mitogen-activated protein kinase kinase 1	Homo sapiens	78-82
35215307-5	2022	Flavonoids (n = 1289) were virtually screened using molecular docking and have revealed possible inhibitors of MEK1.	Flavonoids	0-10	mitogen-activated protein kinase kinase 1	Homo sapiens	111-115
35215307-6	2022	The top five scoring flavonoids based on binding affinity (highest score for MEK1 is -10.8 kcal/mol) have been selected for further protein-ligand interaction analysis.	Flavonoids	21-31	mitogen-activated protein kinase kinase 1	Homo sapiens	77-81
35215307-8	2022	The selected flavonoids of MEK1 have been refined with 30 (ns) molecular dynamics (MD) simulation.	Flavonoids	13-23	mitogen-activated protein kinase kinase 1	Homo sapiens	27-31
35215307-9	2022	The five selected flavonoids are strongly suggested to be promising potent inhibitors for drug development as anticancer therapeutics of the therapeutic target MEK1.	Flavonoids	18-28	mitogen-activated protein kinase kinase 1	Homo sapiens	160-164
35285194-0	2022	(Contributions of flavonoids from citri reticulatae pericarpium to gastric hormones, CD3~+ and TFF3 mRNA expression in rats with spleen deficiency intervened by Liujunzi Decoction).	Flavonoids	18-28	trefoil factor 3	Rattus norvegicus	95-99
35102562-10	2022	PRACTICAL APPLICATIONS: In this paper, we show that flavonoids in okra may help diabetes by inhibiting the PTP1B and PPAR-pathways.	Flavonoids	52-62	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	107-112
35102562-11	2022	This is significant because little research has been done on the impact of flavonoid chemicals in A. esculentus on the expression of PTP1B and PPAR using traditional methods of diabetes treatment.	Flavonoids	75-84	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	133-138
35040205-6	2022	Thus, this study aims to identify the promising flavonoids as the antagonist of miRNAs (pre-miR21, pri-miR-208a, pri-miR-378a, pri-miR320b, pri-miR-300, pri-miR-19b, and pre-miR-20b) using molecular docking simulations studies.	Flavonoids	48-58	microRNA 21	Homo sapiens	92-97
35040205-6	2022	Thus, this study aims to identify the promising flavonoids as the antagonist of miRNAs (pre-miR21, pri-miR-208a, pri-miR-378a, pri-miR320b, pri-miR-300, pri-miR-19b, and pre-miR-20b) using molecular docking simulations studies.	Flavonoids	48-58	microRNA 208a	Homo sapiens	103-111
35040205-6	2022	Thus, this study aims to identify the promising flavonoids as the antagonist of miRNAs (pre-miR21, pri-miR-208a, pri-miR-378a, pri-miR320b, pri-miR-300, pri-miR-19b, and pre-miR-20b) using molecular docking simulations studies.	Flavonoids	48-58	microRNA 378a	Homo sapiens	117-125
35040205-6	2022	Thus, this study aims to identify the promising flavonoids as the antagonist of miRNAs (pre-miR21, pri-miR-208a, pri-miR-378a, pri-miR320b, pri-miR-300, pri-miR-19b, and pre-miR-20b) using molecular docking simulations studies.	Flavonoids	48-58	microRNA 300	Homo sapiens	144-151
35040205-6	2022	Thus, this study aims to identify the promising flavonoids as the antagonist of miRNAs (pre-miR21, pri-miR-208a, pri-miR-378a, pri-miR320b, pri-miR-300, pri-miR-19b, and pre-miR-20b) using molecular docking simulations studies.	Flavonoids	48-58	microRNA 19b-1	Homo sapiens	157-164
35040205-6	2022	Thus, this study aims to identify the promising flavonoids as the antagonist of miRNAs (pre-miR21, pri-miR-208a, pri-miR-378a, pri-miR320b, pri-miR-300, pri-miR-19b, and pre-miR-20b) using molecular docking simulations studies.	Flavonoids	48-58	microRNA 20b	Homo sapiens	174-181
35040205-7	2022	Among the tested flavonoids, narirutin showed highest binding energy (-11.7 kcal/mol) against pri-miR19b followed by pri-miR-378a (-11.4 kcal/mol) >  pri-miR320b (-11.2 kcal/mol) =  pri-miR-300 (-11.2 kcal/mol) >  pri-miR-208a (-9.0 kcal/mol) >  pre-miR-20b (- 8.3 kcal/mol).	Flavonoids	17-27	microRNA 19b-1	Homo sapiens	98-104
35387543-9	2022	Introduction of a 57diOHF moiety into these methoxylated flavonoids caused decreased in oxidation by CYP1B1 and 2A13.	Flavonoids	57-67	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	101-116
35285194-4	2022	Additionally, the effects of flavonoids from CRP in 15 batches of Liujunzi Decoction on the content of GAS, MTL, and VIP, TFF3 mRNA expression, and percentage of CD3~+ T-cells of model rats with spleen deficiency were determined.	Flavonoids	29-39	gastrin	Rattus norvegicus	103-106
35285194-4	2022	Additionally, the effects of flavonoids from CRP in 15 batches of Liujunzi Decoction on the content of GAS, MTL, and VIP, TFF3 mRNA expression, and percentage of CD3~+ T-cells of model rats with spleen deficiency were determined.	Flavonoids	29-39	vasoactive intestinal peptide	Rattus norvegicus	117-120
35285194-4	2022	Additionally, the effects of flavonoids from CRP in 15 batches of Liujunzi Decoction on the content of GAS, MTL, and VIP, TFF3 mRNA expression, and percentage of CD3~+ T-cells of model rats with spleen deficiency were determined.	Flavonoids	29-39	trefoil factor 3	Rattus norvegicus	122-126
35153751-0	2021	Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFbeta/SMAD3 and JAK2/STAT3 Signaling Pathways.	Flavonoids	8-17	SMAD family member 3	Mus musculus	96-101
35140796-15	2022	Conclusions: The findings of this study indicated that selected active flavonoid compounds might play therapeutic roles in glioma mainly through the PI3K-Akt signaling pathway.	Flavonoids	71-80	AKT serine/threonine kinase 1	Homo sapiens	154-157
35215286-1	2022	Myricetin is a common plant-derived flavonoid, considered an agonist of glucagon-like peptide 1 (GLP-1) receptor.	Flavonoids	36-45	glucagon	Rattus norvegicus	72-95
35215286-1	2022	Myricetin is a common plant-derived flavonoid, considered an agonist of glucagon-like peptide 1 (GLP-1) receptor.	Flavonoids	36-45	glucagon-like peptide 1 receptor	Rattus norvegicus	97-112
35153751-0	2021	Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFbeta/SMAD3 and JAK2/STAT3 Signaling Pathways.	Flavonoids	8-17	Janus kinase 2	Mus musculus	106-110
35153751-0	2021	Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFbeta/SMAD3 and JAK2/STAT3 Signaling Pathways.	Flavonoids	8-17	signal transducer and activator of transcription 3	Mus musculus	111-116
35039839-7	2022	In Arabidopsis, over-expression of miR172 reduced flavonoid (including anthocyanins and flavonols) concentration and RNA transcript abundance of flavonoid genes in plantlets cultured on medium containing 7% sucrose.	Flavonoids	50-59	MIR172a	Arabidopsis thaliana	35-41
35208174-13	2022	This study paves the way to further develop compounds from this series or related flavonoids with improved inhibitory activity against AKR1C3.	Flavonoids	82-92	aldo-keto reductase family 1 member C3	Homo sapiens	135-141
35159424-2	2022	According to HPLC analysis, PCR-C aged 10 years (PCR-C10) had the highest flavonoids content, especially polymethoxyflavones (PMFs), compared with the fresh peel of Citrus reticulata cv.	Flavonoids	74-84	homeobox C10	Homo sapiens	53-56
35159424-5	2022	Pretreatment with flavonoids-rich PCR-C samples (particularly PCR-C10) considerably reversed t-BHP-induced oxidative damage in HepG2 cells by improving cell viability, increasing SOD activity and GSH levels and reducing the overproduction of ROS and MDA.	Flavonoids	18-28	homeobox C10	Homo sapiens	66-69
35162981-3	2022	We assessed the cell cycle, viability, proliferation, subcellular localization of the translocation factor EB (TFEB), number and distribution of lysosomes, and glycosaminoglycan synthesis after exposure to flavonoids.	Flavonoids	206-216	transcription factor EB	Homo sapiens	86-109
35162981-3	2022	We assessed the cell cycle, viability, proliferation, subcellular localization of the translocation factor EB (TFEB), number and distribution of lysosomes, and glycosaminoglycan synthesis after exposure to flavonoids.	Flavonoids	206-216	transcription factor EB	Homo sapiens	111-115
35162981-6	2022	The combination of both flavonoids synergistically inhibits glycosaminoglycan synthesis, modulates TFEB localization, lysosomal number, and distribution.	Flavonoids	24-34	transcription factor EB	Homo sapiens	99-103
35039839-7	2022	In Arabidopsis, over-expression of miR172 reduced flavonoid (including anthocyanins and flavonols) concentration and RNA transcript abundance of flavonoid genes in plantlets cultured on medium containing 7% sucrose.	Flavonoids	145-154	MIR172a	Arabidopsis thaliana	35-41
35039839-9	2022	These results indicate that miR172 inhibits flavonoid biosynthesis through suppressing the expression of an AP2 transcription factor that positively regulates MdMYB10.	Flavonoids	44-53	MIR172a	Arabidopsis thaliana	28-34
35111179-1	2021	ELONGATED HYPOCOTYL5 (HY5), a bZIP-type transcription factor, acts as a master regulator that regulates various physiological and biological processes in plants such as photomorphogenesis, root growth, flavonoid biosynthesis and accumulation, nutrient acquisition, and response to abiotic stresses.	Flavonoids	202-211	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	22-25
35057487-0	2022	An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles.	Flavonoids	78-88	ring finger protein 130	Homo sapiens	52-74
35111187-3	2021	NtMYB330 can interact with flavonoid-related bHLH partner NtAn1b and WDR protein NtAn11-1, and the NtMYB330-NtAn1b complex is required to achieve strong transcriptional activation of the PA-related structural genes NtDFR1, NtANS1, NtLAR1 and NtANR1.	Flavonoids	27-36	basic helix-loop-helix protein A-like	Nicotiana tabacum	58-64
35111187-3	2021	NtMYB330 can interact with flavonoid-related bHLH partner NtAn1b and WDR protein NtAn11-1, and the NtMYB330-NtAn1b complex is required to achieve strong transcriptional activation of the PA-related structural genes NtDFR1, NtANS1, NtLAR1 and NtANR1.	Flavonoids	27-36	basic helix-loop-helix protein A-like	Nicotiana tabacum	108-114
35111562-1	2022	The present research scintillates on the homology modelling of rat mitochondrial protein tyrosine phosphatase 1 (PTPMT1) and targeting its activity using flavonoids through a computational docking approach.	Flavonoids	154-164	protein tyrosine phosphatase, mitochondrial 1	Rattus norvegicus	113-119
35111562-11	2022	Thus, flavonoids could act as potential inhibitors of PTPMT1, and further, in-vitro and in-vivo studies are essential to complete the drug development process.	Flavonoids	6-16	protein tyrosine phosphatase, mitochondrial 1	Rattus norvegicus	54-60
35088951-0	2022	Anti-adipogenic effect of the flavonoids through the activation of AMPK in palmitate (PA)-treated HepG2 cells.	Flavonoids	30-40	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	67-71
34994311-0	2022	The role of flavonoids in inhibiting IL-6 and inflammatory arthritis.	Flavonoids	12-22	interleukin 6	Homo sapiens	37-41
34994311-7	2022	This review thoroughly discusses the accumulate data on the role of flavonoids on IL-6 in RA.	Flavonoids	68-78	interleukin 6	Homo sapiens	82-86
32897165-0	2022	Deciphering inhibitory activity of flavonoids against tau protein kinases: a coupled molecular docking and quantum chemical study.	Flavonoids	35-45	microtubule associated protein tau	Homo sapiens	54-57
35053900-4	2022	In the current study, baicalein, a typical bioactive flavonoid, was found to inhibit AChE competitively, with an associated IC50 value of 6.42 +- 0.07 microM, through a monophasic kinetic process.	Flavonoids	53-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
35088951-7	2022	The potential interaction between the flavonoids and the gamma-subunit of AMPK was investigated by molecular docking analysis.	Flavonoids	38-48	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	74-78
35088951-9	2022	In addition, the flavonoids showed increased 2-NBDG uptake in an insulin-independent manner in PA-treated HepG2 cells.	Flavonoids	17-27	insulin	Homo sapiens	65-72
35050153-8	2022	Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK).	Flavonoids	45-55	dipeptidyl peptidase 4	Homo sapiens	163-185
35088951-10	2022	The flavonoids increased the AMPK, ACC, and GSK3beta phosphorylation levels and decreased the SREBP-2 and HMGCR expression levels in PA-treated HepG2 cells.	Flavonoids	4-14	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	29-33
35088951-10	2022	The flavonoids increased the AMPK, ACC, and GSK3beta phosphorylation levels and decreased the SREBP-2 and HMGCR expression levels in PA-treated HepG2 cells.	Flavonoids	4-14	glycogen synthase kinase 3 alpha	Homo sapiens	44-52
35088951-10	2022	The flavonoids increased the AMPK, ACC, and GSK3beta phosphorylation levels and decreased the SREBP-2 and HMGCR expression levels in PA-treated HepG2 cells.	Flavonoids	4-14	sterol regulatory element binding transcription factor 2	Homo sapiens	94-101
35050153-8	2022	Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK).	Flavonoids	45-55	glucagon	Homo sapiens	123-146
35050153-8	2022	Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK).	Flavonoids	45-55	glucagon	Homo sapiens	148-153
35088951-10	2022	The flavonoids increased the AMPK, ACC, and GSK3beta phosphorylation levels and decreased the SREBP-2 and HMGCR expression levels in PA-treated HepG2 cells.	Flavonoids	4-14	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	106-111
35050153-8	2022	Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK).	Flavonoids	45-55	dipeptidyl peptidase 4	Homo sapiens	198-203
35088951-11	2022	Molecular docking analysis showed that the flavonoids bind to the CBS domains in the regulatory gamma-subunit of AMPK with high binding affinities and could serve as potential AMPK activators.	Flavonoids	43-53	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	113-117
35050153-8	2022	Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK).	Flavonoids	45-55	glucagon	Homo sapiens	156-161
35088951-11	2022	Molecular docking analysis showed that the flavonoids bind to the CBS domains in the regulatory gamma-subunit of AMPK with high binding affinities and could serve as potential AMPK activators.	Flavonoids	43-53	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	176-180
35050153-8	2022	Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK).	Flavonoids	45-55	cholecystokinin	Homo sapiens	229-244
35088951-12	2022	CONCLUSION: The overall results suggest that the anti-adipogenic effect of flavonoids on PA-treated HepG2 cells results from the activation of AMPK by flavonoids.	Flavonoids	75-85	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	143-147
35088951-12	2022	CONCLUSION: The overall results suggest that the anti-adipogenic effect of flavonoids on PA-treated HepG2 cells results from the activation of AMPK by flavonoids.	Flavonoids	151-161	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	143-147
35050153-8	2022	Furthermore, the inference can be drawn that flavonoids may protect against IBD through modulating enterohormones, such as glucagon-like peptide 1 (GLP-1), GLP-2, dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors), ghrelin and cholecystokinin (CCK).	Flavonoids	45-55	cholecystokinin	Homo sapiens	246-249
35307675-8	2022	The administration of flavonoid quercetin for 7 days helps to reduce the level of C-reactive protein in the blood serum of animals with experimental bacterial and immune periodontitis.	Flavonoids	22-31	C-reactive protein	Rattus norvegicus	82-100
35522879-11	2022	The administration of bioflavonoids led to the changes in alpha-amylase activity in the submandibular SGs tissues: its values exceeded the relevant data in the control group II by 40.4% (under curcumin administration), by 38.2% (under epigallocatechin-3-gallate administration), and by 34.1% (under quercetin administration); under those conditions aquaporin-5 concentration grew in 2.66, 2.61 and 2.55 times, respectively.	Flavonoids	22-35	aquaporin 5	Rattus norvegicus	349-360
35522879-13	2022	The administration of the bioflavonoids increases the level of cNOS coupling, and improves the functional status of the submandibular SGs under the combined administration of alcohol and LPS enhancing the activity of alpha-amylase and concentration of aquaporin-5.	Flavonoids	26-39	nitric oxide synthase 3	Rattus norvegicus	63-67