PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33330868-4	2021	We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection.	N-(2-mercaptoethyl)-1,3-diaminopropane	48-55	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	140-145
4006082-1	1985	N-(2-mercaptoethyl)-1,3-diaminopropane (WR1065) protects against radiation-induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in V79 Chinese hamster lung fibroblast cells.	N-(2-mercaptoethyl)-1,3-diaminopropane	0-38	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	119-166
4006082-1	1985	N-(2-mercaptoethyl)-1,3-diaminopropane (WR1065) protects against radiation-induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in V79 Chinese hamster lung fibroblast cells.	N-(2-mercaptoethyl)-1,3-diaminopropane	0-38	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	168-173
33330868-4	2021	We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection.	N-(2-mercaptoethyl)-1,3-diaminopropane	48-55	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	215-220
11341985-3	2001	Similarly, the thiol-reducing agents N-(2-mercaptoethyl)-1,3-diaminopropane and dithiothreitol strongly activated both JNK and p38 MAPK in cells undergoing HS.	N-(2-mercaptoethyl)-1,3-diaminopropane	37-75	mitogen-activated protein kinase 8	Rattus norvegicus	119-122
31760490-4	2019	However, in the presence of ALP and amifostine, the product of hydrolysis [2-(3-aminopropylamino)ethanethiol] triggers the decomposition of the MnO2 nanosheets.	N-(2-mercaptoethyl)-1,3-diaminopropane	75-108	alkaline phosphatase, placental	Homo sapiens	28-31
16601878-6	2006	A modest effect of cysteamine (and two related aminothiols, WR 1065 and dimethylaminoethanethiol, DMAET) on PPT substrate accumulation in INCL lymphoblasts was observed.	N-(2-mercaptoethyl)-1,3-diaminopropane	60-67	palmitoyl-protein thioesterase 1	Homo sapiens	108-111
34745529-5	2021	Here, we report that WR-1065, the active species of the approved drug amifostine, covalently modifies 14-3-3sigma at an isoform-unique cysteine residue, Cys38.	N-(2-mercaptoethyl)-1,3-diaminopropane	21-28	stratifin	Homo sapiens	102-113