PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17626162-8	2007	Both effects were reduced upon inhibition of Pin1 activity by the use of an inhibitor juglone and down-regulating Pin1 levels through the use of Pin1 small interfering RNA.	juglone	86-93	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	45-49
16675464-9	2006	In both cases, juglone, a Pin1 pharmacological inhibitor, partially prevented dephosphorylation of Tau at Thr-231 among a set of phosphoepitopes tested.	juglone	15-22	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	26-30
17311089-7	2007	Combined transcriptional and post-transcriptional blockade with cyclosporine A and the Pin1 inhibitor, juglone, was synergistic.	juglone	103-110	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	87-91
16675464-9	2006	In both cases, juglone, a Pin1 pharmacological inhibitor, partially prevented dephosphorylation of Tau at Thr-231 among a set of phosphoepitopes tested.	juglone	15-22	microtubule associated protein tau	Homo sapiens	99-102
16871793-5	2006	The adaptation of yeast cells to H2O2, menadione, and juglone was associated with an increase in the activity of cellular catalase, superoxide dismutase, glucose-6-phosphate dehydrogenase, and glutathione reductase, the main enzymes involved in cell defense against oxidative stress.	juglone	54-61	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	154-187
16354662-10	2006	DNCB, juglone, and tetryl were highly cytotoxic and induced caspase-3/7 activation in HeLa cells.	juglone	6-13	caspase 3	Homo sapiens	60-69
16354662-11	2006	Furthermore, DNCB and juglone were potent inducers of apoptosis also in Bcl2 overexpressing HeLa cells or in A549 cells.	juglone	22-29	BCL2 apoptosis regulator	Homo sapiens	72-76
15171797-8	2004	Finally, the post-mitotic dephosphorylation of both CC-3 and MPM-2 antigens was prevented when cellular Pin1 activity was blocked by the selective inhibitor juglone.	juglone	157-164	C-C motif chemokine ligand 14	Homo sapiens	52-56
16271620-4	2005	This response may have been triggered by DNA damage since juglone induced a rapid and strong phosphorylation of H2AX in all phases of the cell cycle.	juglone	58-65	H2A.X variant histone	Homo sapiens	112-116
16271620-6	2005	Surprisingly, juglone caused a drastic reduction of the basal level of p53 in human fibroblasts and this loss could not be fully rescued by proteasome and calpain I inhibitors.	juglone	14-21	tumor protein p53	Homo sapiens	71-74
15649316-8	2005	Of these, both juglone and celastrol were effective in reversing the abnormal cellular localization of full-length mutant huntingtin observed in mutant HdhQ111/Q111 striatal cells.	juglone	15-22	huntingtin	Mus musculus	122-132
15171797-8	2004	Finally, the post-mitotic dephosphorylation of both CC-3 and MPM-2 antigens was prevented when cellular Pin1 activity was blocked by the selective inhibitor juglone.	juglone	157-164	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	104-108
14617065-8	2003	The chemical juglone (5-hydroxy-1,4-naphthoquinone) inhibited the interaction, suggesting that peptidyl-prolyl isomerization may mediate auxin-induced SHY2/IAA3 protein turnover.	juglone	13-20	AUX/IAA transcriptional regulator family protein	Arabidopsis thaliana	151-155
15112735-7	2004	Therefore, the effect of juglone on H+-ATPase activity in corn and soybean root microsomes was tested.	juglone	25-32	plasma membrane ATPase 4	Glycine max	36-45
15112735-8	2004	Juglone treatments from 10 to 1000 microM significantly reduced H+-ATPase activity compared to controls.	juglone	0-7	plasma membrane ATPase 4	Glycine max	64-73
15112735-9	2004	This inhibition of H+-ATPase activity and observed reduction of water uptake offers a logical explanation for previously documented phytotoxicity of juglone.	juglone	149-156	plasma membrane ATPase 4	Glycine max	19-28
14617065-8	2003	The chemical juglone (5-hydroxy-1,4-naphthoquinone) inhibited the interaction, suggesting that peptidyl-prolyl isomerization may mediate auxin-induced SHY2/IAA3 protein turnover.	juglone	13-20	AUX/IAA transcriptional regulator family protein	Arabidopsis thaliana	156-160
14617065-8	2003	The chemical juglone (5-hydroxy-1,4-naphthoquinone) inhibited the interaction, suggesting that peptidyl-prolyl isomerization may mediate auxin-induced SHY2/IAA3 protein turnover.	juglone	22-50	AUX/IAA transcriptional regulator family protein	Arabidopsis thaliana	151-155
14617065-8	2003	The chemical juglone (5-hydroxy-1,4-naphthoquinone) inhibited the interaction, suggesting that peptidyl-prolyl isomerization may mediate auxin-induced SHY2/IAA3 protein turnover.	juglone	22-50	AUX/IAA transcriptional regulator family protein	Arabidopsis thaliana	156-160
11118437-3	2001	Similar to human Pin1 and yeast Ess1, it exhibits catalytic activity toward substrates containing (Thr(P)/Ser(P))-Pro peptide bonds and comparable inhibition kinetics with juglone.	juglone	172-179	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	17-21
11533036-12	2001	The association of NHERF-1 with Pin1 facilitated dephosphorylation of NHERF-1, as shown in experiments in which cellular Pin1 activity was blocked by the selective inhibitor juglone.	juglone	174-181	SLC9A3 regulator 1	Homo sapiens	19-26
11533036-12	2001	The association of NHERF-1 with Pin1 facilitated dephosphorylation of NHERF-1, as shown in experiments in which cellular Pin1 activity was blocked by the selective inhibitor juglone.	juglone	174-181	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	32-36
11533036-12	2001	The association of NHERF-1 with Pin1 facilitated dephosphorylation of NHERF-1, as shown in experiments in which cellular Pin1 activity was blocked by the selective inhibitor juglone.	juglone	174-181	SLC9A3 regulator 1	Homo sapiens	70-77
11533036-12	2001	The association of NHERF-1 with Pin1 facilitated dephosphorylation of NHERF-1, as shown in experiments in which cellular Pin1 activity was blocked by the selective inhibitor juglone.	juglone	174-181	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	121-125
14525938-4	2003	The expression of hsp-16-2 induced by the pro-oxidant juglone and by heat shock was significantly suppressed by 86% and 33%, respectively, in the transgenic nematode fed with EGb 761.	juglone	54-61	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	18-26
11118437-3	2001	Similar to human Pin1 and yeast Ess1, it exhibits catalytic activity toward substrates containing (Thr(P)/Ser(P))-Pro peptide bonds and comparable inhibition kinetics with juglone.	juglone	172-179	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	32-36
8579568-0	1996	Characterization of zeta-crystallin inhibition by juglone.	juglone	50-57	quinone oxidoreductase	Cavia porcellus	20-35
11160900-0	2001	Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription.	juglone	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	55-59
11160900-4	2001	However, an inhibitor of Pin1, 5-hydroxy-1,4-naphthoquinone (juglone), blocked transcription by RNA polymerase II.	juglone	61-68	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	25-29
8579568-3	1996	Whereas camel lens zeta-crystallin showed hyperbolic saturation curves only with PAQ and NADPH, but slightly segmoidal with juglone.	juglone	124-131	quinone oxidoreductase	Cavia porcellus	19-34
8579568-6	1996	The guinea pig lens zeta-crystallin catalyzed the reduction of Juglone far more efficiently than that of the camel lens zeta-crystallin.	juglone	63-70	quinone oxidoreductase	Cavia porcellus	20-35
8579568-7	1996	Juglone did not serve as an efficient substrate for both zeta-crystallins compared to PAQ and appeared to act as a potent competitive inhibitor, with Kl values of 75 nM and 20 microM for guinea pig lens zeta-crystallin and camel lens zeta-crystallin, respectively.	juglone	0-7	quinone oxidoreductase	Cavia porcellus	203-218
8579568-9	1996	The inhibition mechanism of guinea pig and camel lens zeta-crystallin by juglone is discussed.	juglone	73-80	quinone oxidoreductase	Cavia porcellus	54-69
8037450-9	1994	Catalase and metal chelating agents decreased juglone-induced cell killing, whereas H2O2 increased it.	juglone	46-53	catalase	Homo sapiens	0-8
34438124-0	2021	Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors.	juglone	13-20	endogenous retrovirus group K member 25	Homo sapiens	67-77
2105855-6	1990	Superoxide dismutase exerted two distinct effects on the autoxidation of naphthohydroquinones formed during DT-diaphorase catalysis: on the one hand, it enhanced slightly the autoxidation of 1,4-naphthohydroquinones with a hydroxyl substituent in the benzene ring: 5-hydroxy-1,4-naphthoquinone and the corresponding derivatives with methyl- and/or glutathionyl substituents at C2 and C3, respectively.	juglone	265-293	NAD(P)H quinone dehydrogenase 1	Homo sapiens	108-121
33800170-7	2021	Inhibition of PIN1 using juglone prevented the IL-34-induced transformation of JB6 C141 cells.	juglone	25-32	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	14-18
33800170-7	2021	Inhibition of PIN1 using juglone prevented the IL-34-induced transformation of JB6 C141 cells.	juglone	25-32	interleukin 34	Homo sapiens	47-52
33800170-9	2021	Consistent with these results, the synergistic model showed that treatment with juglone suppressed the IL-34-induced growth of tumors formed by 4T1 cells in BALB/c mice.	juglone	80-87	interleukin 34	Mus musculus	103-108
2119908-4	1990	Single topical applications of 1,4-naphthoquinone and its 5-hydroxy analog (juglone) produced dose-dependent increases in epidermal ODC activity in the dose range 880-3520 nmol/mouse.	juglone	76-83	ornithine decarboxylase, structural 1	Mus musculus	132-135
34438124-3	2021	Herein, a set of 1,4-naphthoquinones with juglone skeleton were prepared and evaluated for the inhibitory efficacy against SARS-CoV-2 Mpro.	juglone	42-49	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	134-138
34786049-3	2021	Treatment with Pin1 inhibitor Juglone or Pin1-specific siRNAs ameliorated the expression of Pin1 and proliferating cell nuclear antigen (PCNA) in human pulmonary artery smooth muscle cells (PASMCs) in vitro, and Juglone treatment arrested the cell cycle at the G1 phase.	juglone	30-37	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	15-19
34778666-8	2021	The results demonstrated that xanthotoxol and 5-hydroxy-1,4-naphthalenedione can be screened as hit compounds for potential agonists of hRyR1 to exert the anxiolytic effect.	juglone	46-76	ryanodine receptor 1	Homo sapiens	136-141
34786049-3	2021	Treatment with Pin1 inhibitor Juglone or Pin1-specific siRNAs ameliorated the expression of Pin1 and proliferating cell nuclear antigen (PCNA) in human pulmonary artery smooth muscle cells (PASMCs) in vitro, and Juglone treatment arrested the cell cycle at the G1 phase.	juglone	30-37	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	92-96
34786049-3	2021	Treatment with Pin1 inhibitor Juglone or Pin1-specific siRNAs ameliorated the expression of Pin1 and proliferating cell nuclear antigen (PCNA) in human pulmonary artery smooth muscle cells (PASMCs) in vitro, and Juglone treatment arrested the cell cycle at the G1 phase.	juglone	30-37	proliferating cell nuclear antigen	Homo sapiens	101-135
34786049-3	2021	Treatment with Pin1 inhibitor Juglone or Pin1-specific siRNAs ameliorated the expression of Pin1 and proliferating cell nuclear antigen (PCNA) in human pulmonary artery smooth muscle cells (PASMCs) in vitro, and Juglone treatment arrested the cell cycle at the G1 phase.	juglone	30-37	proliferating cell nuclear antigen	Homo sapiens	137-141
34786049-7	2021	Additionally, PAR rats displayed higher serum and lung TGF-beta1 levels compared with controls, while administration of Juglone to PAR rats suppressed serum and lung TGF-beta1 levels.	juglone	120-127	transforming growth factor, beta 1	Rattus norvegicus	166-175
34379232-5	2022	Pin1 inhibitor, juglone significantly decreased TGF-beta signalling, increased BMP signalling, normalized their hyper-proliferative, and inflammatory phenotype.	juglone	16-23	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
34572316-6	2021	PiB and juglone, two Pin1 inhibitors inhibited Pin1 activity in neutrophils and consequently inhibited fMLP-induced chemotaxis and -degranulation of azurophil and specific granules as measured by myeloperoxidase and neutrophil gelatinase-associated lipocalin (NGAL) release respectively.	juglone	8-15	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	47-51
34572316-6	2021	PiB and juglone, two Pin1 inhibitors inhibited Pin1 activity in neutrophils and consequently inhibited fMLP-induced chemotaxis and -degranulation of azurophil and specific granules as measured by myeloperoxidase and neutrophil gelatinase-associated lipocalin (NGAL) release respectively.	juglone	8-15	formyl peptide receptor 1	Homo sapiens	103-107
34572316-7	2021	We also showed that PiB inhibited TNFalpha + fMLP-induced superoxide production, confirming the effect of juglone.	juglone	106-113	tumor necrosis factor	Homo sapiens	34-42
34572316-7	2021	We also showed that PiB inhibited TNFalpha + fMLP-induced superoxide production, confirming the effect of juglone.	juglone	106-113	formyl peptide receptor 1	Homo sapiens	45-49
34379232-5	2022	Pin1 inhibitor, juglone significantly decreased TGF-beta signalling, increased BMP signalling, normalized their hyper-proliferative, and inflammatory phenotype.	juglone	16-23	transforming growth factor alpha	Homo sapiens	48-56
34379232-6	2022	Juglone treatment reversed vascular remodelling through reducing TGF-beta signalling in monocrotaline + shunt-PAH rat model.	juglone	0-7	transforming growth factor alpha	Rattus norvegicus	65-73
34336974-0	2021	Effects of Juglone on Neutrophil Degranulation and Myeloperoxidase Activity Related to Equine Laminitis.	juglone	11-18	myeloperoxidase	Equus caballus	51-66
34373763-7	2021	Inhibition of Pin1 with juglone decreased renal structural and functional injuries, as well as oxidative stress.	juglone	24-31	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	14-18
34373763-8	2021	Besides, Pin1 inhibition with the inhibitor, juglone, or the small interfering RNA showed significant reduction on oxidative stress markers caused by the H/R process in vitro.	juglone	45-52	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	9-13
34336974-4	2021	We report for the first time the inhibitory activity of juglone on the degranulation of neutrophils induced by cytochalasin B and formyl-methionyl-leucyl-phenylalanine as monitored by the MPO release (>90% inhibition for 25 and 50 muM).	juglone	56-63	myeloperoxidase	Equus caballus	188-191
34336974-6	2021	These results are confirmed by a docking study showing the perfect positioning of juglone in the MPO enzyme active site and its interaction with one of the amino acids (Arg-239) of MPO apoprotein.	juglone	82-89	myeloperoxidase	Equus caballus	97-100
34336974-6	2021	These results are confirmed by a docking study showing the perfect positioning of juglone in the MPO enzyme active site and its interaction with one of the amino acids (Arg-239) of MPO apoprotein.	juglone	82-89	myeloperoxidase	Equus caballus	181-184
35433695-0	2022	Juglone and KPT6566 Suppress the Tumorigenic Potential of CD44+CD133+ Tumor-Initiating Caco-2 Cells In Vitro and In Vivo.	juglone	0-7	CD44 molecule (Indian blood group)	Homo sapiens	58-62
34285767-9	2021	Moreover, under H2O2 and juglone treatment, a large amount of ROS was produced, and phosphorylation of p53 was induced.	juglone	25-32	transformation related protein 53, pseudogene	Mus musculus	103-106
35416857-4	2022	Suppression of Pin1 with juglone afforded protection against I/R-mediated kidney dysfunction, and reduced I/R-induced endoplasmic reticulum (ER) stress in vivo.	juglone	25-32	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	15-19
34374656-0	2021	The therapeutic effects of the peptidyl-prolyl cis/trans isomerase Pin1 inhibitor juglone on animal-model experimental autoimmune encephalomyelitis.	juglone	82-89	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	31-71
34374656-4	2021	Numerous studies have shown that juglone effectively inhibits Pin1 activity.	juglone	33-40	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	62-66
34374656-5	2021	However, the effect of Pin1 inhibitor juglone on autoimmune diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), remain incomplete.	juglone	38-45	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	23-27
34374656-6	2021	So the present study aimed to explore the therapeutic effects of the Pin1 inhibitor juglone on EAE.	juglone	84-91	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	69-73
34374656-11	2021	The study also found that juglone suppresses pathogenic Th1 and Th17 cells and the expression of CD83 and MHCII on dendritic cells in EAE.	juglone	26-33	CD83 antigen	Mus musculus	97-101
34374656-11	2021	The study also found that juglone suppresses pathogenic Th1 and Th17 cells and the expression of CD83 and MHCII on dendritic cells in EAE.	juglone	26-33	histocompatibility-2, MHC	Mus musculus	106-111
35433695-0	2022	Juglone and KPT6566 Suppress the Tumorigenic Potential of CD44+CD133+ Tumor-Initiating Caco-2 Cells In Vitro and In Vivo.	juglone	0-7	prominin 1	Homo sapiens	63-68
35433695-7	2022	Finally, when CD44+CD133+ tumor-initiating Caco-2 cells were injected into NSG mice, Juglone or KPT6566 led to a meaningful reduction in tumor volume and mass compared with tumors isolated from mice that received control treatment.	juglone	85-92	CD44 molecule (Indian blood group)	Homo sapiens	14-18
35433695-7	2022	Finally, when CD44+CD133+ tumor-initiating Caco-2 cells were injected into NSG mice, Juglone or KPT6566 led to a meaningful reduction in tumor volume and mass compared with tumors isolated from mice that received control treatment.	juglone	85-92	prominin 1	Homo sapiens	19-24
35058248-3	2022	We hypothesised that Pin1 plays a substantial role in PAH and its inhibition with a natural organic compound, Juglone, would reverse experimental pulmonary hypertension (PH).We demonstrated that the expression of Pin1 was markedly elevated in experimental PH (i.e. hypoxia induced mouse and Sugen/hypoxia induced rat models) and pulmonary arterial smooth muscle cells (PASMCs) of patients with clinical PAH.	juglone	110-117	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	21-25
35058248-3	2022	We hypothesised that Pin1 plays a substantial role in PAH and its inhibition with a natural organic compound, Juglone, would reverse experimental pulmonary hypertension (PH).We demonstrated that the expression of Pin1 was markedly elevated in experimental PH (i.e. hypoxia induced mouse and Sugen/hypoxia induced rat models) and pulmonary arterial smooth muscle cells (PASMCs) of patients with clinical PAH.	juglone	110-117	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	213-217
35058248-4	2022	In vitro Pin1 inhibition by either Juglone treatment or siRNA knock-down resulted in an induction of apoptosis and decrease in proliferation of human pulmonary vascular cells.	juglone	35-42	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	9-13
35058248-6	2022	Juglone administration lowered pulmonary vascular resistance, enhanced RV function, improved pulmonary vascular and cardiac remodelling in the Sugen/hypoxia rat model of PAH and the chronic hypoxia-induced PH model in mice.Our study demonstrates that targeting of Pin1 with small molecule inhibitor, Juglone, might be an attractive future therapeutic strategy for PAH and right heart disease secondary to PAH.	juglone	0-7	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	264-268
2973991-0	1988	Effects of the chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone on insect ecdysone 20-monooxygenase activity.	juglone	83-90	shade	Drosophila melanogaster	101-126
33387969-0	2021	Juglone prevents human platelet aggregation through inhibiting Akt and protein disulfide isomerase.	juglone	0-7	AKT serine/threonine kinase 1	Homo sapiens	63-66
3707996-6	1986	Superoxide dismutase induction does not appear to be a response that is specific to paraquat, since another superoxide-generating compound, juglone, caused a similar increase in total superoxide dismutase activity.	juglone	140-147	superoxide dismutase	Zea mays	184-204
947364-3	1976	Reductions of juglone, ferricyanide, indophenol, coenzyme Q, duroquinone, and cytochrome c by NADH are inhibited to different extents on both sides of the membrane by the impermeant hydrophilic chelators bathophenanthroline sulfonate and orthophenanthroline.	juglone	14-21	cytochrome c, somatic	Homo sapiens	78-90
24272053-3	1977	In addition, as has already been shown by others using brain homogenates, juglone inhibits choline acetyltransferase.	juglone	74-81	choline O-acetyltransferase	Rattus norvegicus	91-116
33915494-7	2021	Juglone treatment significantly inhibited the protein levels of IL-6, TNF-alpha and IL-1beta, improved the protein expression of IL-10.	juglone	0-7	interleukin 6	Mus musculus	64-68
33915494-7	2021	Juglone treatment significantly inhibited the protein levels of IL-6, TNF-alpha and IL-1beta, improved the protein expression of IL-10.	juglone	0-7	tumor necrosis factor	Mus musculus	70-79
33915494-7	2021	Juglone treatment significantly inhibited the protein levels of IL-6, TNF-alpha and IL-1beta, improved the protein expression of IL-10.	juglone	0-7	interleukin 1 alpha	Mus musculus	84-92
33915494-7	2021	Juglone treatment significantly inhibited the protein levels of IL-6, TNF-alpha and IL-1beta, improved the protein expression of IL-10.	juglone	0-7	interleukin 10	Mus musculus	129-134
33915494-9	2021	Juglone treatment also inhibited the protein expressions of IL-6, STAT3 and RORgammat, meanwhile improved the protein level of FOXP3.	juglone	0-7	interleukin 6	Mus musculus	60-64
33915494-9	2021	Juglone treatment also inhibited the protein expressions of IL-6, STAT3 and RORgammat, meanwhile improved the protein level of FOXP3.	juglone	0-7	signal transducer and activator of transcription 3	Mus musculus	66-71
33915494-9	2021	Juglone treatment also inhibited the protein expressions of IL-6, STAT3 and RORgammat, meanwhile improved the protein level of FOXP3.	juglone	0-7	forkhead box P3	Mus musculus	127-132
33387969-0	2021	Juglone prevents human platelet aggregation through inhibiting Akt and protein disulfide isomerase.	juglone	0-7	prolyl 4-hydroxylase subunit beta	Homo sapiens	71-98
33387969-5	2021	The effect of juglone on protein disulfide isomerase (PDI) activity was determined by the dieosin glutathione disulfide assay.	juglone	14-21	prolyl 4-hydroxylase subunit beta	Homo sapiens	25-52
33387969-5	2021	The effect of juglone on protein disulfide isomerase (PDI) activity was determined by the dieosin glutathione disulfide assay.	juglone	14-21	prolyl 4-hydroxylase subunit beta	Homo sapiens	54-57
33387969-6	2021	RESULTS: Juglone (1 - 5 muM) inhibited platelet aggregation and glycoprotein (GP) IIb/IIIa activation caused by various agonists.	juglone	9-16	integrin subunit alpha 2b	Homo sapiens	64-85
33387969-9	2021	In contrast, Akt activation caused by various agonists were inhibited in juglone-treated platelets.	juglone	73-80	AKT serine/threonine kinase 1	Homo sapiens	13-16
33387969-10	2021	Additionally, juglone showed inhibitory effects on both recombinant human PDI and platelet surface PDI at concentrations similar to those needed to prevent platelet aggregation.	juglone	14-21	prolyl 4-hydroxylase subunit beta	Homo sapiens	74-77
33387969-10	2021	Additionally, juglone showed inhibitory effects on both recombinant human PDI and platelet surface PDI at concentrations similar to those needed to prevent platelet aggregation.	juglone	14-21	prolyl 4-hydroxylase subunit beta	Homo sapiens	99-102
33387969-11	2021	CONCLUSION: Juglone exhibits potent in vitro antiplatelet and antithrombotic effects that are associated with inhibition of Akt activation and platelet surface PDI activity.	juglone	12-19	AKT serine/threonine kinase 1	Homo sapiens	124-127
33387969-11	2021	CONCLUSION: Juglone exhibits potent in vitro antiplatelet and antithrombotic effects that are associated with inhibition of Akt activation and platelet surface PDI activity.	juglone	12-19	prolyl 4-hydroxylase subunit beta	Homo sapiens	160-163
33071287-5	2020	By using Juglone, a naturally occurring naphthoquinone acting as an anticancer agent, to decrease Notch3 expression and induce ER stress, we observed an increased ER stress-associated apoptosis.	juglone	9-16	notch receptor 3	Homo sapiens	98-104
33375280-5	2020	In addition, RT-qPCR showed downregulation of the expansion-related (HAS2, TNFAIP6, PTX3, and PTGS2) and mitochondrial (ATPase6 and ATP5F1E) genes in juglone-treated COCs.	juglone	150-157	prostaglandin-endoperoxide synthase 2	Bos taurus	94-99
33375280-7	2020	Using immunofluorescence, the apoptotic marker caspase-9 was overexpressed in oocytes exposed to juglone (25.0 microM) compared to the untreated control.	juglone	97-104	caspase 9	Bos taurus	47-56
33502882-0	2021	Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/beta-catenin signaling.	juglone	0-7	catenin beta 1	Homo sapiens	92-104
33064264-3	2021	In acute oxidative stress studies using juglone, loss-of-function grk-2 mutants were more resistant to oxidative stress compared with loss-of-function grk-1 mutants and the wild-type N2 animals.	juglone	40-47	G protein-coupled receptor kinase 2	Caenorhabditis elegans	66-71
33375280-5	2020	In addition, RT-qPCR showed downregulation of the expansion-related (HAS2, TNFAIP6, PTX3, and PTGS2) and mitochondrial (ATPase6 and ATP5F1E) genes in juglone-treated COCs.	juglone	150-157	hyaluronan synthase 2	Bos taurus	69-73
33375280-5	2020	In addition, RT-qPCR showed downregulation of the expansion-related (HAS2, TNFAIP6, PTX3, and PTGS2) and mitochondrial (ATPase6 and ATP5F1E) genes in juglone-treated COCs.	juglone	150-157	TNF alpha induced protein 6	Bos taurus	75-82
33375280-5	2020	In addition, RT-qPCR showed downregulation of the expansion-related (HAS2, TNFAIP6, PTX3, and PTGS2) and mitochondrial (ATPase6 and ATP5F1E) genes in juglone-treated COCs.	juglone	150-157	pentraxin 3	Bos taurus	84-88
32592588-9	2020	Disruption of SUMO1-sumoylation by Pin1 silencing with shRNAs or inhibition with its inhibitor Juglone markedly abrogated GSC maintenance and mitigated GSC-driven tumor growth.	juglone	95-102	small ubiquitin like modifier 1	Homo sapiens	14-19
33071287-6	2020	Altogether our results suggest that Notch3 inhibition may prevent leukemia cells from engaging a functional UPR needed to compensate the Juglone-mediated ER proteotoxic stress.	juglone	137-144	notch receptor 3	Homo sapiens	36-42
33071287-7	2020	Notably, in vivo administration of Juglone to human T-ALL xenotransplant models significantly reduced tumor growth, finally fostering the exploitation of Juglone-dependent Notch3 inhibition to perturb the ER stress/UPR signaling in Notch3-dependent T-ALL subsets.	juglone	35-42	notch receptor 3	Homo sapiens	172-178
33071287-7	2020	Notably, in vivo administration of Juglone to human T-ALL xenotransplant models significantly reduced tumor growth, finally fostering the exploitation of Juglone-dependent Notch3 inhibition to perturb the ER stress/UPR signaling in Notch3-dependent T-ALL subsets.	juglone	35-42	notch receptor 3	Homo sapiens	232-238
33071287-7	2020	Notably, in vivo administration of Juglone to human T-ALL xenotransplant models significantly reduced tumor growth, finally fostering the exploitation of Juglone-dependent Notch3 inhibition to perturb the ER stress/UPR signaling in Notch3-dependent T-ALL subsets.	juglone	154-161	notch receptor 3	Homo sapiens	172-178
33071287-7	2020	Notably, in vivo administration of Juglone to human T-ALL xenotransplant models significantly reduced tumor growth, finally fostering the exploitation of Juglone-dependent Notch3 inhibition to perturb the ER stress/UPR signaling in Notch3-dependent T-ALL subsets.	juglone	154-161	notch receptor 3	Homo sapiens	232-238
32774672-6	2020	Cyclin D1 and MMP-9 levels in the thoracic aorta were lower in diabetic Apoe-/- mice treated with juglone and JQ1 compared with vehicle-treated diabetic Apoe-/- mice.	juglone	98-105	cyclin D1	Mus musculus	0-9
32774672-6	2020	Cyclin D1 and MMP-9 levels in the thoracic aorta were lower in diabetic Apoe-/- mice treated with juglone and JQ1 compared with vehicle-treated diabetic Apoe-/- mice.	juglone	98-105	matrix metallopeptidase 9	Mus musculus	14-19
32774672-6	2020	Cyclin D1 and MMP-9 levels in the thoracic aorta were lower in diabetic Apoe-/- mice treated with juglone and JQ1 compared with vehicle-treated diabetic Apoe-/- mice.	juglone	98-105	apolipoprotein E	Mus musculus	72-76
32646056-0	2020	Juglone Suppresses LPS-induced Inflammatory Responses and NLRP3 Activation in Macrophages.	juglone	0-7	NLR family, pyrin domain containing 3	Mus musculus	58-63
32646056-3	2020	The aim of this study was to explore the effects of juglone (5-hydroxyl-1,4-naphthoquinone) on NLRP3 inflammasome activation.	juglone	52-59	NLR family, pyrin domain containing 3	Mus musculus	95-100
32646056-8	2020	The levels of NLRP3 and cleaved caspase-1, as well as the secretion of IL-1beta and IL-18, were decreased by treatment with juglone in a concentration-dependent manner.	juglone	124-131	NLR family, pyrin domain containing 3	Mus musculus	14-19
32646056-8	2020	The levels of NLRP3 and cleaved caspase-1, as well as the secretion of IL-1beta and IL-18, were decreased by treatment with juglone in a concentration-dependent manner.	juglone	124-131	caspase 1	Mus musculus	32-41
32646056-8	2020	The levels of NLRP3 and cleaved caspase-1, as well as the secretion of IL-1beta and IL-18, were decreased by treatment with juglone in a concentration-dependent manner.	juglone	124-131	interleukin 1 alpha	Mus musculus	71-79
32646056-8	2020	The levels of NLRP3 and cleaved caspase-1, as well as the secretion of IL-1beta and IL-18, were decreased by treatment with juglone in a concentration-dependent manner.	juglone	124-131	interleukin 18	Mus musculus	84-89
32646056-9	2020	Juglone also inhibited the ATPase activities of NLRP3 in LPS/ATP-stimulated J774.1 macrophages.	juglone	0-7	NLR family, pyrin domain containing 3	Mus musculus	48-53
32646056-10	2020	Our results suggested that juglone could inhibit inflammatory cytokine production and NLRP3 inflammasome activation in macrophages, and should be considered as a therapeutic strategy for inflammation-related diseases.	juglone	27-34	NLR family, pyrin domain containing 3	Mus musculus	86-91
31825806-0	2020	Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling.	juglone	31-38	cytochrome b5 type A	Homo sapiens	107-120
32377702-9	2020	In conclusion, juglone potentiated BRAF inhibitor-induced apoptosis in resistant melanoma cells, and these effects occurred partially through ROS and the p38-p53 pathway, suggesting the potential of juglone as a sensitizer to BRAF inhibitors in the treatment of melanoma.	juglone	15-22	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	226-230
32377702-9	2020	In conclusion, juglone potentiated BRAF inhibitor-induced apoptosis in resistant melanoma cells, and these effects occurred partially through ROS and the p38-p53 pathway, suggesting the potential of juglone as a sensitizer to BRAF inhibitors in the treatment of melanoma.	juglone	199-206	tumor protein p53	Homo sapiens	158-161
32521867-11	2020	Annexin V/PI staining showed that the percentage of the apoptotic OVCAR-3 cells increased from 2.15 in control to 45.24% at 60 microM concentration of Juglone.	juglone	151-158	annexin A5	Homo sapiens	0-9
32377702-0	2020	Juglone potentiates BRAF inhibitor-induced apoptosis in melanoma through reactive oxygen species and the p38-p53 pathway.	juglone	0-7	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	20-24
32377702-0	2020	Juglone potentiates BRAF inhibitor-induced apoptosis in melanoma through reactive oxygen species and the p38-p53 pathway.	juglone	0-7	mitogen-activated protein kinase 14	Homo sapiens	105-108
32377702-0	2020	Juglone potentiates BRAF inhibitor-induced apoptosis in melanoma through reactive oxygen species and the p38-p53 pathway.	juglone	0-7	tumor protein p53	Homo sapiens	109-112
32377702-3	2020	In the present study, it was investigated whether juglone could enhance the responses to a BRAF inhibitor in melanoma cells (A375R and SK-MEL-5R) with an acquired resistance.	juglone	50-57	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	91-95
32377702-5	2020	It was demonstrated that the combination of juglone and PLX4032 had synergistic effects on BRAF inhibitor-resistant melanoma cells.	juglone	44-51	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	91-95
32377702-6	2020	Juglone potentiated PLX4032-induced cytotoxicity and mitochondrial apoptosis in both A375R and SK-MEL-5R cells, which was accompanied by a decline in mitochondrial membrane potential and a decrease in Bcl-2/Bax ratio.	juglone	0-7	BCL2 apoptosis regulator	Homo sapiens	201-206
32377702-6	2020	Juglone potentiated PLX4032-induced cytotoxicity and mitochondrial apoptosis in both A375R and SK-MEL-5R cells, which was accompanied by a decline in mitochondrial membrane potential and a decrease in Bcl-2/Bax ratio.	juglone	0-7	BCL2 associated X, apoptosis regulator	Homo sapiens	207-210
32377702-7	2020	Moreover, juglone combined with PLX4032 markedly increased the intracellular level of reactive oxygen species (ROS) and activated p38 and p53, as compared with juglone alone or PLX4032 alone.	juglone	10-17	mitogen-activated protein kinase 14	Homo sapiens	130-133
32377702-7	2020	Moreover, juglone combined with PLX4032 markedly increased the intracellular level of reactive oxygen species (ROS) and activated p38 and p53, as compared with juglone alone or PLX4032 alone.	juglone	10-17	tumor protein p53	Homo sapiens	138-141
32377702-9	2020	In conclusion, juglone potentiated BRAF inhibitor-induced apoptosis in resistant melanoma cells, and these effects occurred partially through ROS and the p38-p53 pathway, suggesting the potential of juglone as a sensitizer to BRAF inhibitors in the treatment of melanoma.	juglone	15-22	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	35-39
31523996-10	2020	Juglone induced relaxation in the phenylephrine, K+ (80 mM), and angiotensin II pretreated isolated rat aortic rings.	juglone	0-7	angiotensinogen	Rattus norvegicus	65-79
31825806-5	2020	We found that 5-hydroxy-1,4-naphthoquinone (known as juglone), a natural naphthoquinone extracted from walnut trees and used historically in traditional medicine with ambiguous health and toxic outcomes, had the ability to uncouple the electron transfer from the reductase to cytochrome b5 and ferricyanide.	juglone	14-42	cytochrome b5 type A	Homo sapiens	276-289
31825806-5	2020	We found that 5-hydroxy-1,4-naphthoquinone (known as juglone), a natural naphthoquinone extracted from walnut trees and used historically in traditional medicine with ambiguous health and toxic outcomes, had the ability to uncouple the electron transfer from the reductase to cytochrome b5 and ferricyanide.	juglone	53-60	cytochrome b5 type A	Homo sapiens	276-289
31825806-6	2020	Upon complex formation with cytochrome b5 reductase, juglone is able to act as an electron acceptor leading to NADH consumption stimulation and increase of superoxide anion production by the reductase.	juglone	53-60	cytochrome b5 type A	Homo sapiens	28-41
31825806-7	2020	Our results suggest that cytochrome b5 reductase could contribute to the measured energetic failure in the erythrocyte apoptosis induced by juglone, that is concomitant with the reactive oxygen species produced by cytochrome b5 reductase.	juglone	140-147	cytochrome b5 type A	Homo sapiens	25-38
31825806-7	2020	Our results suggest that cytochrome b5 reductase could contribute to the measured energetic failure in the erythrocyte apoptosis induced by juglone, that is concomitant with the reactive oxygen species produced by cytochrome b5 reductase.	juglone	140-147	cytochrome b5 type A	Homo sapiens	214-227
31085459-6	2019	Juglone reduced the accumulation of MDSCs and increased IFN-gamma production by CD8+ T cells.	juglone	0-7	interferon gamma	Mus musculus	56-65
31869252-10	2020	The inhibition of an FGFR2 downstream signaling enzyme, PIN1, via genetic knockdown or use of a PIN1 inhibitor, juglone, attenuated the aforementioned deformities in a mouse model of Apert syndrome.	juglone	112-119	fibroblast growth factor receptor 2	Mus musculus	21-26
31869252-10	2020	The inhibition of an FGFR2 downstream signaling enzyme, PIN1, via genetic knockdown or use of a PIN1 inhibitor, juglone, attenuated the aforementioned deformities in a mouse model of Apert syndrome.	juglone	112-119	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	56-60
31869252-10	2020	The inhibition of an FGFR2 downstream signaling enzyme, PIN1, via genetic knockdown or use of a PIN1 inhibitor, juglone, attenuated the aforementioned deformities in a mouse model of Apert syndrome.	juglone	112-119	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	96-100
31283929-0	2019	ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro.	juglone	32-39	tumor protein p53	Homo sapiens	14-17
31540074-3	2019	Here, we investigated the effect of juglone derivatives isolated from Reynoutria japonica on the activity of NRF2 in HeLa cells.	juglone	36-43	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
31085459-8	2019	Moreover, juglone down-regulated the level of IL-1beta which was mediating accumulation of MDSCs.	juglone	10-17	interleukin 1 alpha	Mus musculus	46-54
31331055-7	2019	In addition, the extract increased the levels of the stress response enzyme superoxide dismutase-3 (Sod-3) by 55.5% and decreased the expression of heat shock protein-16.2 (Hsp-16.2) in nematodes, which had been challenged by juglone, by 21%.	juglone	226-233	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	148-171
31331055-7	2019	In addition, the extract increased the levels of the stress response enzyme superoxide dismutase-3 (Sod-3) by 55.5% and decreased the expression of heat shock protein-16.2 (Hsp-16.2) in nematodes, which had been challenged by juglone, by 21%.	juglone	226-233	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	173-181
31184118-3	2019	At an IC50 of 20.81 muM, juglone significantly inhibited Ishikawa cell proliferation, as shown by S phase arrest mediated by inactivation of cyclin A protein ( p < 0.05).	juglone	25-32	latexin	Homo sapiens	20-23
31184118-3	2019	At an IC50 of 20.81 muM, juglone significantly inhibited Ishikawa cell proliferation, as shown by S phase arrest mediated by inactivation of cyclin A protein ( p < 0.05).	juglone	25-32	cyclin A2	Homo sapiens	141-149
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	juglone	57-64	cyclin dependent kinase inhibitor 1A	Homo sapiens	131-134
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	juglone	57-64	cyclin dependent kinase 2	Homo sapiens	166-170
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	juglone	57-64	cell division cycle 25A	Homo sapiens	172-178
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	juglone	57-64	checkpoint kinase 1	Homo sapiens	180-184
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	juglone	57-64	cyclin A2	Homo sapiens	190-198
31184118-5	2019	The expression of Bcl-2 and Bcl-xL was significantly down-regulated, whereas the expression of Bax, Bad and cyto c was up-regulated, and we later confirmed the involvement of the mitochondrial pathway in juglone-induced apoptosis.	juglone	204-211	BCL2 apoptosis regulator	Homo sapiens	18-23
31184118-5	2019	The expression of Bcl-2 and Bcl-xL was significantly down-regulated, whereas the expression of Bax, Bad and cyto c was up-regulated, and we later confirmed the involvement of the mitochondrial pathway in juglone-induced apoptosis.	juglone	204-211	BCL2 like 1	Homo sapiens	28-34
30959841-6	2019	Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer"s disease.	juglone	9-16	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	36-40
30548309-7	2019	Based on our Western blot analyses, Juglone significantly reduced p-Akt levels and increased the expression level of Forkhead box O1 (FoxO1) and FoxO3a proteins.	juglone	36-43	AKT serine/threonine kinase 1	Homo sapiens	68-71
30548309-7	2019	Based on our Western blot analyses, Juglone significantly reduced p-Akt levels and increased the expression level of Forkhead box O1 (FoxO1) and FoxO3a proteins.	juglone	36-43	forkhead box O1	Homo sapiens	117-132
30548309-7	2019	Based on our Western blot analyses, Juglone significantly reduced p-Akt levels and increased the expression level of Forkhead box O1 (FoxO1) and FoxO3a proteins.	juglone	36-43	forkhead box O1	Homo sapiens	134-139
30548309-7	2019	Based on our Western blot analyses, Juglone significantly reduced p-Akt levels and increased the expression level of Forkhead box O1 (FoxO1) and FoxO3a proteins.	juglone	36-43	forkhead box O3	Homo sapiens	145-151
30548309-8	2019	Moreover, hairy/enhancer of split-1 (Hes1) protein, overexpressed under the influence of Juglone, is apparently involved in Juglone-induced apoptosis among K562 cells.	juglone	89-96	hes family bHLH transcription factor 1	Homo sapiens	10-35
30548309-8	2019	Moreover, hairy/enhancer of split-1 (Hes1) protein, overexpressed under the influence of Juglone, is apparently involved in Juglone-induced apoptosis among K562 cells.	juglone	89-96	hes family bHLH transcription factor 1	Homo sapiens	37-41
30548309-8	2019	Moreover, hairy/enhancer of split-1 (Hes1) protein, overexpressed under the influence of Juglone, is apparently involved in Juglone-induced apoptosis among K562 cells.	juglone	124-131	hes family bHLH transcription factor 1	Homo sapiens	10-35
30548309-8	2019	Moreover, hairy/enhancer of split-1 (Hes1) protein, overexpressed under the influence of Juglone, is apparently involved in Juglone-induced apoptosis among K562 cells.	juglone	124-131	hes family bHLH transcription factor 1	Homo sapiens	37-41
31184118-5	2019	The expression of Bcl-2 and Bcl-xL was significantly down-regulated, whereas the expression of Bax, Bad and cyto c was up-regulated, and we later confirmed the involvement of the mitochondrial pathway in juglone-induced apoptosis.	juglone	204-211	BCL2 associated X, apoptosis regulator	Homo sapiens	95-98
30959841-6	2019	Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer"s disease.	juglone	9-16	peptidylprolyl isomerase like 1	Homo sapiens	42-77
30959841-6	2019	Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer"s disease.	juglone	156-163	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	36-40
30709346-13	2019	CONCLUSION: A novel juglone analogue 2-ethoxystypandrone was identified from the EtOAc extract of the roots of P. cuspidatum and was demonstrated to be a potent small-molecule STAT3 signaling inhibitor, which strongly blocked STAT3 activation, inhibited proliferation, and induced cell apoptosis of HCC cells and HCC CSCs.	juglone	20-27	signal transducer and activator of transcription 3	Homo sapiens	176-181
30959841-6	2019	Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer"s disease.	juglone	156-163	peptidylprolyl isomerase like 1	Homo sapiens	42-77
30825814-8	2019	The circular dichroism (CD) spectra signify alterations in the population of alpha-helical content within the secondary structure of LYZ in presence of JUG molecules.	juglone	152-155	lysozyme	Homo sapiens	133-136
30709346-13	2019	CONCLUSION: A novel juglone analogue 2-ethoxystypandrone was identified from the EtOAc extract of the roots of P. cuspidatum and was demonstrated to be a potent small-molecule STAT3 signaling inhibitor, which strongly blocked STAT3 activation, inhibited proliferation, and induced cell apoptosis of HCC cells and HCC CSCs.	juglone	20-27	signal transducer and activator of transcription 3	Homo sapiens	226-231
30419248-8	2019	Our finding was demonstrated by estimating ex-vivo Th1 and Th2 cytokines, flow cytometric analysis of Treg, T-helper memory, and CD8+ cells and determining serum IgG2a/IgG1 titer shift in BCG-vaccinated animals treated with juglone.	juglone	224-231	immunoglobulin heavy variable V1-9	Mus musculus	162-167
30419248-4	2019	We have shown that juglone treatment leads to the generation of Th1 cytokines which develops an M1 phenotype in splenic macrophages.	juglone	19-26	negative elongation factor complex member C/D, Th1l	Mus musculus	64-67
30587016-0	2018	Transcriptional profiling of catalase genes in juglone-treated seeds of maize (Zea mays L.) and wheat (Triticum aestivum L.).	juglone	47-54	catalase-1	Triticum aestivum	29-37
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	71-78	catalase isozyme 1	Zea mays	152-156
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	71-78	catalase isozyme 2	Zea mays	158-162
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	71-78	catalase isozyme 3	Zea mays	167-171
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	71-78	catalase-1	Triticum aestivum	203-211
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	84-112	catalase isozyme 1	Zea mays	152-156
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	84-112	catalase isozyme 2	Zea mays	158-162
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	84-112	catalase isozyme 3	Zea mays	167-171
30587016-1	2018	The major aim of the present study was to investigate the influence of juglone (JU; 5-hydroxy-1,4-naphthoquinone) treatments on the expression level of Cat1, Cat2 and Cat3 genes, encoding the respective catalase isozymes in maize (Zea mays L.) and wheat (Triticum aestivum L.) seeds.	juglone	84-112	catalase-1	Triticum aestivum	203-211
30587016-3	2018	Juglone applications significantly stimulated abundance of three target catalase transcripts as well as induced CAT activity and generation of H2O2 in both maize and wheat kernels.	juglone	0-7	catalase-1	Triticum aestivum	72-80
30587016-3	2018	Juglone applications significantly stimulated abundance of three target catalase transcripts as well as induced CAT activity and generation of H2O2 in both maize and wheat kernels.	juglone	0-7	catalase-1	Triticum aestivum	112-115
29992683-0	2018	Juglone-ascorbic acid synergy inhibits metastasis and induces apoptotic cell death in poorly differentiated thyroid carcinoma by perturbing SOD and catalase activities.	juglone	0-7	catalase	Homo sapiens	148-156
30007339-7	2018	In the pharmacological approach, we intraperitoneally administered juglone, a PIN1 enzyme inhibitor, to pregnant Fgfr2S252W/+ mutant mice and found that this treatment successfully interrupted fetal development of AS phenotypes.	juglone	67-74	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	78-82
30272449-6	2018	We observed that singlet oxygen induced synthesis of the natural product, juglone, is more efficiently catalyzed by PSS-1 than its constituent component Zn-PB.	juglone	74-81	corneodesmosin	Homo sapiens	116-121
29992683-5	2018	This combination also affects enzyme activity of catalase, glutathione reductase, and superoxide dismutase destabilizing redox balance in cell and thereby making juglone effective at a lower dose.	juglone	162-169	catalase	Homo sapiens	49-57
29992683-5	2018	This combination also affects enzyme activity of catalase, glutathione reductase, and superoxide dismutase destabilizing redox balance in cell and thereby making juglone effective at a lower dose.	juglone	162-169	glutathione-disulfide reductase	Homo sapiens	59-80
30013652-0	2018	Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3beta/Snail signaling pathway.	juglone	0-7	protein tyrosine kinase 2 beta	Homo sapiens	86-102
30013652-0	2018	Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3beta/Snail signaling pathway.	juglone	0-7	glycogen synthase kinase 3 beta	Homo sapiens	103-133
30013652-0	2018	Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3beta/Snail signaling pathway.	juglone	0-7	snail family transcriptional repressor 1	Homo sapiens	134-139
30013652-6	2018	Results from western blot analysis demonstrated that juglone increases the expression of the epithelial marker E-cadherin while decreasing the expression of mesenchymal markers (N-cadherin and Vimentin) in a dose-dependent manner.	juglone	53-60	cadherin 1	Homo sapiens	111-121
30013652-6	2018	Results from western blot analysis demonstrated that juglone increases the expression of the epithelial marker E-cadherin while decreasing the expression of mesenchymal markers (N-cadherin and Vimentin) in a dose-dependent manner.	juglone	53-60	cadherin 2	Homo sapiens	178-188
30013652-6	2018	Results from western blot analysis demonstrated that juglone increases the expression of the epithelial marker E-cadherin while decreasing the expression of mesenchymal markers (N-cadherin and Vimentin) in a dose-dependent manner.	juglone	53-60	vimentin	Homo sapiens	193-201
30013652-8	2018	Furthermore, juglone prevented inactivation of glycogen synthase kinase-3beta (GSK-3beta), an endogenous inhibitor of Snail in a dose-dependent manner.	juglone	13-20	glycogen synthase kinase 3 beta	Homo sapiens	47-77
30013652-8	2018	Furthermore, juglone prevented inactivation of glycogen synthase kinase-3beta (GSK-3beta), an endogenous inhibitor of Snail in a dose-dependent manner.	juglone	13-20	glycogen synthase kinase 3 beta	Homo sapiens	79-88
30013652-8	2018	Furthermore, juglone prevented inactivation of glycogen synthase kinase-3beta (GSK-3beta), an endogenous inhibitor of Snail in a dose-dependent manner.	juglone	13-20	snail family transcriptional repressor 1	Homo sapiens	118-123
30013652-9	2018	Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin.	juglone	58-65	glycogen synthase kinase 3 beta	Homo sapiens	27-36
30013652-9	2018	Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin.	juglone	58-65	snail family transcriptional repressor 1	Homo sapiens	93-98
30013652-9	2018	Lithium chloride (LiCl), a GSK-3beta inhibitor, prevented juglone-mediated downregulation of Snail expression and upregulation of E-cadherin.	juglone	58-65	cadherin 1	Homo sapiens	130-140
30013652-11	2018	Inhibition of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt pathway by LY294002 augmented juglone-mediated GSK-3beta activity by inhibiting Ser9 phosphorylation.	juglone	106-113	AKT serine/threonine kinase 1	Homo sapiens	72-75
30013652-11	2018	Inhibition of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt pathway by LY294002 augmented juglone-mediated GSK-3beta activity by inhibiting Ser9 phosphorylation.	juglone	106-113	glycogen synthase kinase 3 beta	Homo sapiens	123-132
30013652-12	2018	These findings indicated that juglone suppresses EMT via the Akt/GSK-3beta/Snail pathway, consequently decreasing the invasiveness of PC cells.	juglone	30-37	AKT serine/threonine kinase 1	Homo sapiens	61-64
30013652-12	2018	These findings indicated that juglone suppresses EMT via the Akt/GSK-3beta/Snail pathway, consequently decreasing the invasiveness of PC cells.	juglone	30-37	glycogen synthase kinase 3 beta	Homo sapiens	65-74
30013652-12	2018	These findings indicated that juglone suppresses EMT via the Akt/GSK-3beta/Snail pathway, consequently decreasing the invasiveness of PC cells.	juglone	30-37	snail family transcriptional repressor 1	Homo sapiens	75-80
29039537-0	2017	Juglone potentiates TRAIL-induced apoptosis in human melanoma cells via activating the ROS-p38-p53 pathway.	juglone	0-7	TNF superfamily member 10	Homo sapiens	20-25
28986099-10	2018	In vivo data from ApoE-/- mice showed that treatment of juglone led to accelerated atherosclerosis development.	juglone	56-63	apolipoprotein E	Mus musculus	18-22
28962834-8	2018	Pre-incubation of Pin1 with Juglone but not Plumbagin, reduced TF release as microvesicles and was also achievable following transfection with Pin1-siRNA.	juglone	28-35	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	18-22
28962834-8	2018	Pre-incubation of Pin1 with Juglone but not Plumbagin, reduced TF release as microvesicles and was also achievable following transfection with Pin1-siRNA.	juglone	28-35	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	143-147
29895782-6	2018	Inhibition of protein never in mitosis gene A interacting-1 (PIN1) by juglone or small interfering RNA reversed the effects of melatonin on EtOH-mediated senescence as well as osteoblastic and osteoclastic differentiation.	juglone	70-77	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	61-65
29039537-0	2017	Juglone potentiates TRAIL-induced apoptosis in human melanoma cells via activating the ROS-p38-p53 pathway.	juglone	0-7	mitogen-activated protein kinase 14	Homo sapiens	91-94
29039537-0	2017	Juglone potentiates TRAIL-induced apoptosis in human melanoma cells via activating the ROS-p38-p53 pathway.	juglone	0-7	tumor protein p53	Homo sapiens	95-98
29039537-4	2017	In the present study, it was demonstrated that juglone sensitized melanoma cells to TRAIL-induced cytotoxicity by MTT and crystal violet assays.	juglone	47-54	TNF superfamily member 10	Homo sapiens	84-89
29039537-5	2017	Flow cytometry analysis indicated that juglone potentiated TRAIL-induced cell death.	juglone	39-46	TNF superfamily member 10	Homo sapiens	59-64
29039537-8	2017	However, exposure to TRAIL in combination with juglone markedly increased the production of ROS, activated p38 and increased p53, compared with the cells treated with either juglone or TRAIL alone.	juglone	47-54	mitogen-activated protein kinase 14	Homo sapiens	107-110
29039537-8	2017	However, exposure to TRAIL in combination with juglone markedly increased the production of ROS, activated p38 and increased p53, compared with the cells treated with either juglone or TRAIL alone.	juglone	47-54	tumor protein p53	Homo sapiens	125-128
29039537-8	2017	However, exposure to TRAIL in combination with juglone markedly increased the production of ROS, activated p38 and increased p53, compared with the cells treated with either juglone or TRAIL alone.	juglone	47-54	TNF superfamily member 10	Homo sapiens	185-190
29039537-8	2017	However, exposure to TRAIL in combination with juglone markedly increased the production of ROS, activated p38 and increased p53, compared with the cells treated with either juglone or TRAIL alone.	juglone	174-181	TNF superfamily member 10	Homo sapiens	21-26
29039537-9	2017	Pretreatment with N-acetyl cysteine, a ROS scavenger, significantly reduced the cytotoxicity of juglone in combination with TRAIL, which further supported that ROS was involved in the juglone-induced sensitization of TRAIL.	juglone	96-103	TNF superfamily member 10	Homo sapiens	217-222
29039537-9	2017	Pretreatment with N-acetyl cysteine, a ROS scavenger, significantly reduced the cytotoxicity of juglone in combination with TRAIL, which further supported that ROS was involved in the juglone-induced sensitization of TRAIL.	juglone	184-191	TNF superfamily member 10	Homo sapiens	124-129
29039537-9	2017	Pretreatment with N-acetyl cysteine, a ROS scavenger, significantly reduced the cytotoxicity of juglone in combination with TRAIL, which further supported that ROS was involved in the juglone-induced sensitization of TRAIL.	juglone	184-191	TNF superfamily member 10	Homo sapiens	217-222
29039537-10	2017	In conclusion, juglone potentiated TRAIL-induced apoptosis in melanoma cells, and these effects were partially mediated through the ROS-p38-p53 pathway.	juglone	15-22	TNF superfamily member 10	Homo sapiens	35-40
29039537-10	2017	In conclusion, juglone potentiated TRAIL-induced apoptosis in melanoma cells, and these effects were partially mediated through the ROS-p38-p53 pathway.	juglone	15-22	mitogen-activated protein kinase 14	Homo sapiens	136-139
29039537-10	2017	In conclusion, juglone potentiated TRAIL-induced apoptosis in melanoma cells, and these effects were partially mediated through the ROS-p38-p53 pathway.	juglone	15-22	tumor protein p53	Homo sapiens	140-143
29039537-11	2017	These findings suggested that juglone may be a potential sensitizer for TRAIL therapy in the treatment of melanoma.	juglone	30-37	TNF superfamily member 10	Homo sapiens	72-77
28791366-3	2017	Recently, juglone, a Pin1 inhibitor, was shown to exhibit potent anticancer activity in various tumor cells, but its role in human glioma cells remains unknown.	juglone	10-17	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	21-25
28900141-5	2017	DXN significantly suppressed the expression of hsp-16.2 induced by juglone, and up-regulated sod-3 expression.	juglone	67-74	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	47-55
28791366-6	2017	The results showed that 5-20 microM juglone markedly suppressed cell proliferation, induced apoptosis, and enhanced caspase-3 activity in U251 cells in a dose- and time-dependent manner.	juglone	36-43	caspase 3	Homo sapiens	116-125
28791366-10	2017	Moreover, the transient overexpression of Pin1 reversed its antitumor effects in U251 cells and inhibited juglone-mediated changes to the TGF-beta1/miR-21 signaling pathway.	juglone	106-113	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	42-46
28791366-10	2017	Moreover, the transient overexpression of Pin1 reversed its antitumor effects in U251 cells and inhibited juglone-mediated changes to the TGF-beta1/miR-21 signaling pathway.	juglone	106-113	transforming growth factor beta 1	Homo sapiens	138-147
28791366-10	2017	Moreover, the transient overexpression of Pin1 reversed its antitumor effects in U251 cells and inhibited juglone-mediated changes to the TGF-beta1/miR-21 signaling pathway.	juglone	106-113	microRNA 21	Homo sapiens	148-154
28791366-11	2017	These findings suggest that juglone inhibits cell growth by causing apoptosis, thereby inhibiting the migration of U251 glioma cells and disrupting angiogenesis; and that Pin1 is a critical target for juglone"s antitumor activity.	juglone	201-208	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	171-175
28930240-6	2017	RESULTS: 1,2-Naphthoquinone and 5-hydroxy-1,4-naphthoquinone elicited the greatest anti-S. pyogenes activities with MICs ranging from 0.39 to 6.25 microg mL-1 and MBCs of 100 microg mL-1.	juglone	32-60	L1 cell adhesion molecule	Mus musculus	154-158
28885586-6	2017	Also, in an in vivo model, the extract increased the survival rate of Caenorhabditis elegans worms pretreated with the pro-oxidant juglone from 43 to 64%, decreased intracellular ROS inside the wild-type nematodes by 47.90%, and induced nuclear translocation of the transcription factor DAF-16 in the transgenic strain TJ356.	juglone	131-138	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	287-293
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	BCL2 associated X, apoptosis regulator	Homo sapiens	27-30
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	Fas ligand	Homo sapiens	43-47
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	caspase 3	Homo sapiens	49-58
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	mitogen-activated protein kinase 8	Homo sapiens	62-65
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-77
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	BCL2 associated X, apoptosis regulator	Homo sapiens	208-211
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	Fas ligand	Homo sapiens	224-228
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	caspase 3	Homo sapiens	230-239
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	mitogen-activated protein kinase 8	Homo sapiens	243-246
28756921-5	2017	The protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun in cells treated with juglone were significantly higher than those of control group (P < 0.05), and the protein expressions of Bax, CytC, Fas, FasL, Caspase-3, p-JNK and p-c-Jun increased more remarkably as the juglone dosage increased (P < 0.05).	juglone	100-107	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	253-258
28198538-4	2017	Treatment of PIN1 inhibitor juglone, and gene silencing by RNA interference promoted osteoblast differentiation in PDLCs and cementoblasts, whereas the overexpression of PIN1 inhibited.	juglone	28-35	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	13-17
28930240-6	2017	RESULTS: 1,2-Naphthoquinone and 5-hydroxy-1,4-naphthoquinone elicited the greatest anti-S. pyogenes activities with MICs ranging from 0.39 to 6.25 microg mL-1 and MBCs of 100 microg mL-1.	juglone	32-60	L1 cell adhesion molecule	Mus musculus	182-186
28232511-6	2017	Juglone (Pin1 inhibitor) or vehicle was injected intraperitoneally before I/R challenge.	juglone	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	9-13
27439725-2	2016	The in vitro results showed that hepatic differentiation was suppressed by infection with adenovirus-PIN1 and promoted by PIN1 inhibitor juglone via the downregulation of Wnt3a and beta-catenin.	juglone	137-144	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	122-126
28388894-0	2017	Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma.	juglone	0-7	mitogen-activated protein kinase 14	Homo sapiens	63-66
28388894-9	2017	RESULTS: Juglone could obviously inhibit the proliferation of TSCs in glioma by decreasing cell viability (P < 0.01) and inducing apoptosis (P < 0.01), which was accompanied by increased caspase 9 cleavage in a dose-dependent manner (P < 0.01).	juglone	9-16	caspase 9	Homo sapiens	193-202
28388894-10	2017	In the meantime, juglone could generate ROS significantly and increase p38 phosphorylation (P < 0.01).	juglone	17-24	mitogen-activated protein kinase 14	Homo sapiens	71-74
28388894-11	2017	In addition, pretreatment with ROS scavenger or p38-MAPK inhibitor could reverse juglone-induced cytotoxicity (P < 0.01).	juglone	81-88	mitogen-activated protein kinase 14	Homo sapiens	48-51
28388894-13	2017	CONCLUSIONS: Juglone could inhibit the growth of TSCs in gliomas through the activation of ROS-p38-MAPK pathway in vitro, and the anti-glioma effect was validated in vivo, which offers a potential therapeutic agent to gliomas.	juglone	13-20	mitogen-activated protein kinase 14	Homo sapiens	95-98
27770268-0	2017	Sensitizing effect of juglone is mediated by down regulation of Notch1 signaling pathway in trastuzumab-resistant SKBR3 cells.	juglone	22-29	notch receptor 1	Homo sapiens	64-70
27770268-5	2017	Besides, Pin1 inhibition via juglone reduced the extent of proliferation, colony formation and migration capacity of resistant SKBR3 cells.	juglone	29-36	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	9-13
27770268-6	2017	In addition, despite a feed forward loop between Notch1 and Pin1 in sensitive SKBR3 cells, inhibition of Notch1 cleavage in resistant SKBR3 cells did not affect pin1 level whereas pin1 inhibition by juglone reduced the level of Hes1, p-Akt and increased the cellular content of Numb.	juglone	199-206	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	180-184
27770268-6	2017	In addition, despite a feed forward loop between Notch1 and Pin1 in sensitive SKBR3 cells, inhibition of Notch1 cleavage in resistant SKBR3 cells did not affect pin1 level whereas pin1 inhibition by juglone reduced the level of Hes1, p-Akt and increased the cellular content of Numb.	juglone	199-206	hes family bHLH transcription factor 1	Homo sapiens	228-232
27634219-7	2016	These increases are effectively prevented by the inhibition of Pin1 by juglone.	juglone	71-78	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	63-67
28300760-7	2017	Compared with ApoE-/- mice, treatment by juglone resulted not only in markedly attenuated macrophage infiltration and atherosclerotic lesion area in a lipid-independent manner, but also in decreased expression of Pin1, vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and NF-kappaB activity in aorta.	juglone	41-48	apolipoprotein E	Mus musculus	14-18
28300760-7	2017	Compared with ApoE-/- mice, treatment by juglone resulted not only in markedly attenuated macrophage infiltration and atherosclerotic lesion area in a lipid-independent manner, but also in decreased expression of Pin1, vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and NF-kappaB activity in aorta.	juglone	41-48	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	213-217
28300760-7	2017	Compared with ApoE-/- mice, treatment by juglone resulted not only in markedly attenuated macrophage infiltration and atherosclerotic lesion area in a lipid-independent manner, but also in decreased expression of Pin1, vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and NF-kappaB activity in aorta.	juglone	41-48	vascular cell adhesion molecule 1	Mus musculus	219-252
28300760-7	2017	Compared with ApoE-/- mice, treatment by juglone resulted not only in markedly attenuated macrophage infiltration and atherosclerotic lesion area in a lipid-independent manner, but also in decreased expression of Pin1, vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and NF-kappaB activity in aorta.	juglone	41-48	vascular cell adhesion molecule 1	Mus musculus	254-260
28300760-7	2017	Compared with ApoE-/- mice, treatment by juglone resulted not only in markedly attenuated macrophage infiltration and atherosclerotic lesion area in a lipid-independent manner, but also in decreased expression of Pin1, vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and NF-kappaB activity in aorta.	juglone	41-48	chemokine (C-C motif) ligand 2	Mus musculus	263-297
28300760-7	2017	Compared with ApoE-/- mice, treatment by juglone resulted not only in markedly attenuated macrophage infiltration and atherosclerotic lesion area in a lipid-independent manner, but also in decreased expression of Pin1, vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and NF-kappaB activity in aorta.	juglone	41-48	chemokine (C-C motif) ligand 2	Mus musculus	299-304
28300760-9	2017	It was observed that treatment with juglone or Pin1 siRNA suppressed expression of VCAM-1 in oxLDL-incubated EA.hy926 cells and decreased THP-1 cell adhesion to oxLDL-stimulated endothelial cells through the NF-kappaB signal pathway.	juglone	36-43	vascular cell adhesion molecule 1	Homo sapiens	83-89
27439725-2	2016	The in vitro results showed that hepatic differentiation was suppressed by infection with adenovirus-PIN1 and promoted by PIN1 inhibitor juglone via the downregulation of Wnt3a and beta-catenin.	juglone	137-144	wingless-type MMTV integration site family, member 3A	Mus musculus	171-176
27439725-2	2016	The in vitro results showed that hepatic differentiation was suppressed by infection with adenovirus-PIN1 and promoted by PIN1 inhibitor juglone via the downregulation of Wnt3a and beta-catenin.	juglone	137-144	catenin (cadherin associated protein), beta 1	Mus musculus	181-193
27178251-5	2016	The PIN1 inhibitor juglone suppressed neuronal differentiation but promoted glial differentiation as assessed by the number of Nissl-positive cells and mRNA expression of neuronal markers (nestin, betaIII-tubulin, and NeuN) and a glial marker (glial fibrillary acidic protein).	juglone	19-26	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	4-8
27283994-0	2016	Juglone ameliorates skin wound healing by promoting skin cell migration through Rac1/Cdc42/PAK pathway.	juglone	0-7	Rac family small GTPase 1	Mus musculus	80-84
27283994-0	2016	Juglone ameliorates skin wound healing by promoting skin cell migration through Rac1/Cdc42/PAK pathway.	juglone	0-7	cell division cycle 42	Mus musculus	85-90
27283994-10	2016	Taken together, these data suggest that juglone may be a potential candidate for wound healing and skin regeneration which ameliorates wound healing mainly by promoting skin cell migration through Rac1/Cdc42/PAK pathway.	juglone	40-47	Rac family small GTPase 1	Mus musculus	197-201
27283994-10	2016	Taken together, these data suggest that juglone may be a potential candidate for wound healing and skin regeneration which ameliorates wound healing mainly by promoting skin cell migration through Rac1/Cdc42/PAK pathway.	juglone	40-47	cell division cycle 42	Mus musculus	202-207
27525860-11	2016	The results suggest that the mechanism of juglone-induced apoptosis in MCF-7 cells is characterized by elevated ROS levels, reduced Bcl-2 expression, increased Bax expression, decreased mitochondrial membrane potential, increased intracellular Ca(2+) concentration, outer mitochondrial-membrane rupture, cytochrome C release, and caspase-3 activation.	juglone	42-49	BCL2 apoptosis regulator	Homo sapiens	132-137
27525860-11	2016	The results suggest that the mechanism of juglone-induced apoptosis in MCF-7 cells is characterized by elevated ROS levels, reduced Bcl-2 expression, increased Bax expression, decreased mitochondrial membrane potential, increased intracellular Ca(2+) concentration, outer mitochondrial-membrane rupture, cytochrome C release, and caspase-3 activation.	juglone	42-49	BCL2 associated X, apoptosis regulator	Homo sapiens	160-163
27525860-11	2016	The results suggest that the mechanism of juglone-induced apoptosis in MCF-7 cells is characterized by elevated ROS levels, reduced Bcl-2 expression, increased Bax expression, decreased mitochondrial membrane potential, increased intracellular Ca(2+) concentration, outer mitochondrial-membrane rupture, cytochrome C release, and caspase-3 activation.	juglone	42-49	cytochrome c, somatic	Homo sapiens	304-316
27525860-11	2016	The results suggest that the mechanism of juglone-induced apoptosis in MCF-7 cells is characterized by elevated ROS levels, reduced Bcl-2 expression, increased Bax expression, decreased mitochondrial membrane potential, increased intracellular Ca(2+) concentration, outer mitochondrial-membrane rupture, cytochrome C release, and caspase-3 activation.	juglone	42-49	caspase 3	Homo sapiens	330-339
27155528-5	2016	The cells were treated with juglone at <IC50 doses (5, 10, 15 and 20muM ) for 24h.	juglone	28-35	latexin	Homo sapiens	71-74
27155528-9	2016	A significant reduction of MMP-2, MMP-9 and Phactr-1 expressions was observed in pancreatic cancer cells after the treatment of juglone at <IC50 doses.	juglone	128-135	matrix metallopeptidase 2	Homo sapiens	27-32
27155528-9	2016	A significant reduction of MMP-2, MMP-9 and Phactr-1 expressions was observed in pancreatic cancer cells after the treatment of juglone at <IC50 doses.	juglone	128-135	matrix metallopeptidase 9	Homo sapiens	34-39
27155528-9	2016	A significant reduction of MMP-2, MMP-9 and Phactr-1 expressions was observed in pancreatic cancer cells after the treatment of juglone at <IC50 doses.	juglone	128-135	phosphatase and actin regulator 1	Homo sapiens	44-52
27178251-5	2016	The PIN1 inhibitor juglone suppressed neuronal differentiation but promoted glial differentiation as assessed by the number of Nissl-positive cells and mRNA expression of neuronal markers (nestin, betaIII-tubulin, and NeuN) and a glial marker (glial fibrillary acidic protein).	juglone	19-26	RNA binding fox-1 homolog 3	Homo sapiens	218-222
26223922-0	2015	Effect of Pin1 inhibitor juglone on proliferation, migration and angiogenic ability of breast cancer cell line MCF7Adr.	juglone	25-32	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	10-14
26898501-2	2016	TrxR1 can catalyze efficient reduction of juglone (5-hydroxy-1,4-naphthoquinone; walnut toxin) in a reaction which, in contrast to reduction of most other substrates of TrxR1, is not dependent upon an intact selenocysteine (Sec, U) residue of the enzyme.	juglone	42-49	thioredoxin reductase 1	Homo sapiens	0-5
26898501-2	2016	TrxR1 can catalyze efficient reduction of juglone (5-hydroxy-1,4-naphthoquinone; walnut toxin) in a reaction which, in contrast to reduction of most other substrates of TrxR1, is not dependent upon an intact selenocysteine (Sec, U) residue of the enzyme.	juglone	42-49	thioredoxin reductase 1	Homo sapiens	169-174
26898501-2	2016	TrxR1 can catalyze efficient reduction of juglone (5-hydroxy-1,4-naphthoquinone; walnut toxin) in a reaction which, in contrast to reduction of most other substrates of TrxR1, is not dependent upon an intact selenocysteine (Sec, U) residue of the enzyme.	juglone	51-79	thioredoxin reductase 1	Homo sapiens	0-5
26898501-3	2016	Using a number of TrxR1 mutant variants, we here found that a sole Cys residue at the C-terminal tail of TrxR1 is required for high-efficiency juglone-coupled NADPH oxidase activity of Sec-deficient enzyme, occurring with mixed one- and two-electron reactions producing superoxide.	juglone	143-150	thioredoxin reductase 1	Homo sapiens	105-110
26898501-6	2016	Ala substitutions of Trp407, Asn418 and Asn419 in a previously described "guiding bar", thought to mediate interactions of the C-terminal tail of TrxR1 with the FAD/dithiol site at the N-terminal domain of the other subunit in the dimeric enzyme, lowered turnover with juglone about 4.5-fold.	juglone	269-276	thioredoxin reductase 1	Homo sapiens	146-151
26898501-7	2016	Four residues of Sec-deficient TrxR1 were found to be easily arylated by juglone, including the Cys residue at position 497.	juglone	73-80	thioredoxin reductase 1	Homo sapiens	31-36
26898501-8	2016	Based upon our observations we suggest a model for involvement of the juglone-arylated C-terminal motif of TrxR1 to explain its high activity with juglone.	juglone	70-77	thioredoxin reductase 1	Homo sapiens	107-112
26898501-8	2016	Based upon our observations we suggest a model for involvement of the juglone-arylated C-terminal motif of TrxR1 to explain its high activity with juglone.	juglone	147-154	thioredoxin reductase 1	Homo sapiens	107-112
26898501-10	2016	One-electron juglone reduction by TrxR1 producing superoxide should furthermore contribute to the well-known prooxidant cytotoxicity of juglone.	juglone	13-20	thioredoxin reductase 1	Homo sapiens	34-39
26898501-10	2016	One-electron juglone reduction by TrxR1 producing superoxide should furthermore contribute to the well-known prooxidant cytotoxicity of juglone.	juglone	136-143	thioredoxin reductase 1	Homo sapiens	34-39
26905390-2	2016	Three of the assayed compounds, namely, boropinal (3), juglone (5), and plumbagin (7), acted as strong modulators of TRPA1 channels with EC50 values of 9.8, 1.7, and 0.5 muM, respectively, as assessed by Ca(2+) assays.	juglone	55-62	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	117-122
26126609-0	2015	Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of alpha-SMA and collagen III.	juglone	27-34	actin gamma 2, smooth muscle	Rattus norvegicus	156-165
26126609-2	2015	Juglone, which is a quinone, significantly decreased DMN-induced rat hepatic fibrosis, which was associated with increased superoxide dismutase (SOD) activity, decreased oxidative stress and reduced levels of alpha-smooth muscle actin (alpha-SMA) and collagen (Col) III in the liver.	juglone	0-7	actin gamma 2, smooth muscle	Rattus norvegicus	209-234
26126609-2	2015	Juglone, which is a quinone, significantly decreased DMN-induced rat hepatic fibrosis, which was associated with increased superoxide dismutase (SOD) activity, decreased oxidative stress and reduced levels of alpha-smooth muscle actin (alpha-SMA) and collagen (Col) III in the liver.	juglone	0-7	actin gamma 2, smooth muscle	Rattus norvegicus	236-245
26126609-3	2015	Serum levels of alanine aminotransferase, aspartate aminotransferase, hyaluronic acid, laminin, type III precollagen and type IV collagen were significantly reduced by treatment with juglone.	juglone	183-190	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	42-68
26126609-9	2015	It was hypothesized that juglone alleviates or mitigates oxidative stress-mediated hepatic fibrosis by upregulating the expression of peroxisome proliferator-activated receptor gamma and inhibiting the activation of HSC.	juglone	25-32	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	134-182
26583846-0	2016	Pin1 inhibitor Juglone prevents diabetic vascular dysfunction.	juglone	15-22	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
26583846-13	2016	CONCLUSION: Pharmacological inhibition of Pin1 by Juglone prevents hyperglycemia-induced vascular dysfunction.	juglone	50-57	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	42-46
26622856-6	2015	The results of the present study revealed that knockdown of Pin1 in glioblastoma cells using RNA interference or the selective Pin1 inhibitor, juglone, suppressed the tumorigenic features by reducing cell growth, migration and angiogenic potential.	juglone	143-150	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	60-64
26622856-6	2015	The results of the present study revealed that knockdown of Pin1 in glioblastoma cells using RNA interference or the selective Pin1 inhibitor, juglone, suppressed the tumorigenic features by reducing cell growth, migration and angiogenic potential.	juglone	143-150	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	127-131
26622856-8	2015	Due to the fundamental roles of Pin1 in promoting tumorigenesis, Pin1 inhibitory molecules, including juglone, or alternative synthetic derivatives hold potential for the development of clinical countermeasures against glioblastoma.	juglone	102-109	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	65-69
26223922-1	2015	This study aimed to evaluate the effects of Pin1 inhibitor Juglone on proliferation, migration and the angiogenic ability of breast cancer cell line MCF7Adr.	juglone	59-66	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	44-48
26223922-2	2015	MCF7Adr cells were cultured and separately treated with Pin1 inhibitor Juglone (treatment group) and DMEM without drug (control group).	juglone	71-78	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	56-60
26223922-11	2015	It was suggested that Pin1 inhibitor Juglone can effectively inhibit the proliferation, migration and the angiogenic ability of MCF7Adr cells, and can be used as an alternative drug therapy for breast cancer.	juglone	37-44	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	22-26
25348830-9	2015	Juglone (1-5 muM) significantly increased the percentage of annexin V binding cells.	juglone	0-7	latexin	Homo sapiens	13-16
26221477-8	2015	RESULTS: Juglone significantly inhibited SKOV3 cell proliferation as shown by G0/G1 phase arrest, and this effect was mediated by inactivation of cyclin D1 protein (P<0.05).	juglone	9-16	cyclin D1	Homo sapiens	146-155
26221477-9	2015	Juglone induced apoptosis in SKOV3 cell which was accompanied by caspase-9 and caspase-3 activation (P<0.05).	juglone	0-7	caspase 9	Homo sapiens	65-74
26221477-9	2015	Juglone induced apoptosis in SKOV3 cell which was accompanied by caspase-9 and caspase-3 activation (P<0.05).	juglone	0-7	caspase 3	Homo sapiens	79-88
26221477-11	2015	Juglone sufficiently inhibited invasion while evidently decreased MMP-2 expression (P<0.05).	juglone	0-7	matrix metallopeptidase 2	Homo sapiens	66-71
24265246-7	2015	In a xenograft model, treatment of TKI, a COT inhibitor, and Juglone, a Pin1 inhibitor, abrogates tumor growth.	juglone	61-68	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	72-76
25964086-0	2015	Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-kappaB signaling pathway in high-fat diet rats.	juglone	0-7	toll-like receptor 4	Rattus norvegicus	95-99
25964086-8	2015	Analysis of inflammatory cytokines declared that the inhibition of TNF-alpha, IL-1beta and IL-6 could be carried by juglone in response to high-fat diet rats.	juglone	116-123	tumor necrosis factor	Rattus norvegicus	67-76
25964086-8	2015	Analysis of inflammatory cytokines declared that the inhibition of TNF-alpha, IL-1beta and IL-6 could be carried by juglone in response to high-fat diet rats.	juglone	116-123	interleukin 1 beta	Rattus norvegicus	78-86
25964086-8	2015	Analysis of inflammatory cytokines declared that the inhibition of TNF-alpha, IL-1beta and IL-6 could be carried by juglone in response to high-fat diet rats.	juglone	116-123	interleukin 6	Rattus norvegicus	91-95
25964086-11	2015	These results indicated that juglone prevents high-fat diet-induced liver injury and nerve inflammation in mice through inhibition of inflammatory cytokine secretion, NF-kappa B activation and endotoxin production.	juglone	29-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-177
25348830-10	2015	Juglone (5 muM) significantly increased ceramide abundance at the erythrocyte surface and decreased erythrocyte ATP concentration.	juglone	0-7	latexin	Homo sapiens	11-14
25348830-11	2015	The effect of juglone (10 muM) on annexin V binding was slightly but significantly blunted by removal of extracellular Ca(2+) and by addition of protein kinase C (PKC) inhibitor staurosporine (1 muM).	juglone	14-21	latexin	Homo sapiens	26-29
25348830-11	2015	The effect of juglone (10 muM) on annexin V binding was slightly but significantly blunted by removal of extracellular Ca(2+) and by addition of protein kinase C (PKC) inhibitor staurosporine (1 muM).	juglone	14-21	latexin	Homo sapiens	195-198
25377120-4	2015	Cyclosporine A, FK506, rapamycin and juglone are known PPIase inhibitors.	juglone	37-44	FKBP prolyl isomerase 7	Homo sapiens	55-61
24651852-7	2014	Only nhr-25 was required for wild-type levels of resistance to the bacterial pathogen P. aeruginosa and only acs-3 was required for wild-type levels of resistance to osmotic stress and the oxidative stress generator, juglone.	juglone	217-224	AMP-binding domain-containing protein	Caenorhabditis elegans	109-114
25512367-5	2015	Inhibition of PIN1 by juglone or knockdown of PIN1 gene expression by siRNA markedly attenuated LPS- and nicotine-stimulated prostaglandin E2 (PGE2) and nitric oxide (NO) production, as well as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, whereas PIN1 overexpression by Ad-PIN1 increased it.	juglone	22-29	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	14-18
26075030-5	2015	Presumably due to its antioxidative effects, treatment with TSG decreased the juglone-mediated induction of the antioxidative enzyme SOD-3; the induction of the GST-4 by juglone was diminished slightly.	juglone	78-85	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	133-138
26075030-5	2015	Presumably due to its antioxidative effects, treatment with TSG decreased the juglone-mediated induction of the antioxidative enzyme SOD-3; the induction of the GST-4 by juglone was diminished slightly.	juglone	170-177	Glutathione S-transferase 4	Caenorhabditis elegans	161-166
26726309-10	2015	Juglone-induced GST-4::GFP expression was not attenuated in worms pretreated with the novel compounds, except with C2.	juglone	0-7	Glutathione S-transferase 4	Caenorhabditis elegans	16-21
26726309-15	2015	C2 was also efficient in reducing the juglone-induced GST-4::GFP expression, suggesting the latter may mediate the stress induced by this compound.	juglone	38-45	Glutathione S-transferase 4	Caenorhabditis elegans	54-59
26477796-10	2015	In contrast, inhibiting PIN1 expression via juglone exerted the opposite effects.	juglone	44-51	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	24-28
23002436-11	2012	Our results also show that CL097 induced proline isomerase 1 (Pin1) activation and that juglone, a Pin1 inhibitor, inhibited CL097-mediated priming of fMLF-induced p47phox phosphorylation and superoxide production.	juglone	88-95	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	99-103
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	45-49
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	bone morphogenetic protein 1	Homo sapiens	109-135
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	bone morphogenetic protein 1	Homo sapiens	137-140
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	catenin beta 1	Homo sapiens	147-159
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	mitogen-activated protein kinase 1	Homo sapiens	161-198
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	mitogen-activated protein kinase 1	Homo sapiens	200-203
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	mitogen-activated protein kinase 8	Homo sapiens	206-229
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	mitogen-activated protein kinase 8	Homo sapiens	231-234
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	nuclear factor kappa B subunit 1	Homo sapiens	241-263
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	nuclear factor kappa B subunit 1	Homo sapiens	265-274
24219242-8	2014	Consistently, juglone-mediated inhibition of PIN1 augmented the osteogenic medium (OM)-induced activation of bone morphogenetic protein (BMP), Wnt/beta-catenin, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NF-kappaB) pathway, which response was reversed by Ad-PIN1.	juglone	14-21	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	319-323
24252337-4	2014	EPs7630( ) treatment reduces intracellular hsp-16.2::GFP expression (induced by the pro-oxidant juglone) indicating that the secondary metabolites of EPs7630( ) are bioavailable and exhibit antioxidant activities in vivo.	juglone	96-103	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	43-51
26784668-7	2014	In the C. elegans strain (TJ374, hsp-16.2/GFP), the expression of hsp-16.2/GFP was induced by a nonlethal dose of juglone, and the fluorescence density of hsp-16.2/GFP was measured.	juglone	114-121	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	33-41
26784668-7	2014	In the C. elegans strain (TJ374, hsp-16.2/GFP), the expression of hsp-16.2/GFP was induced by a nonlethal dose of juglone, and the fluorescence density of hsp-16.2/GFP was measured.	juglone	114-121	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	66-74
26784668-7	2014	In the C. elegans strain (TJ374, hsp-16.2/GFP), the expression of hsp-16.2/GFP was induced by a nonlethal dose of juglone, and the fluorescence density of hsp-16.2/GFP was measured.	juglone	114-121	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	66-74
24596388-5	2014	In contrast, juglone, a potent Pin1 inhibitor, significantly enhanced trastuzumab-induced FAS down-regulation and cell death in BT474 cells.	juglone	13-20	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
24596388-5	2014	In contrast, juglone, a potent Pin1 inhibitor, significantly enhanced trastuzumab-induced FAS down-regulation and cell death in BT474 cells.	juglone	13-20	fatty acid synthase	Homo sapiens	90-93
23754278-13	2013	Interestingly, multiple pharmacological Pin1 inhibitors, including juglone, attenuated MPP(+)-induced Pin1 up-regulation, alpha-synuclein aggregation, caspase-3 activation, and cell death.	juglone	67-74	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	40-44
23754278-13	2013	Interestingly, multiple pharmacological Pin1 inhibitors, including juglone, attenuated MPP(+)-induced Pin1 up-regulation, alpha-synuclein aggregation, caspase-3 activation, and cell death.	juglone	67-74	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	102-106
23754278-13	2013	Interestingly, multiple pharmacological Pin1 inhibitors, including juglone, attenuated MPP(+)-induced Pin1 up-regulation, alpha-synuclein aggregation, caspase-3 activation, and cell death.	juglone	67-74	synuclein, alpha	Mus musculus	122-137
23754278-13	2013	Interestingly, multiple pharmacological Pin1 inhibitors, including juglone, attenuated MPP(+)-induced Pin1 up-regulation, alpha-synuclein aggregation, caspase-3 activation, and cell death.	juglone	67-74	caspase 3	Mus musculus	151-160
23754278-14	2013	Furthermore, juglone treatment in the MPTP mouse model of PD suppressed Pin1 levels and improved locomotor deficits, dopamine depletion, and nigral dopaminergic neuronal loss.	juglone	13-20	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	72-76
23469846-5	2013	We found that while suppression of Pin1, either by using its inhibitor Juglone or a shRNA plasmid against Pin1, induces tau hyperphosphorylation and GSK-3beta activation both in vivo and in vitro, inhibition of GSK-3beta by SB216763 or LiCl reverses tau hyperphosphorylation.	juglone	71-78	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	35-39
23469846-5	2013	We found that while suppression of Pin1, either by using its inhibitor Juglone or a shRNA plasmid against Pin1, induces tau hyperphosphorylation and GSK-3beta activation both in vivo and in vitro, inhibition of GSK-3beta by SB216763 or LiCl reverses tau hyperphosphorylation.	juglone	71-78	glycogen synthase kinase 3 beta	Homo sapiens	149-158
23129219-12	2013	When the PIN1 inhibitor juglone was added to the cells, the proliferative effects             of PIN1 were abolished.	juglone	24-31	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	9-13
23129219-12	2013	When the PIN1 inhibitor juglone was added to the cells, the proliferative effects             of PIN1 were abolished.	juglone	24-31	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	97-101
23643730-10	2013	Moreover, we found that juglone significantly inhibited the expression levels of androgen receptor (AR) and prostate-specific antigen (PSA) in a dose-dependent manner, as well as abrogated up-regulation of AR and PSA genes with and/or without dihydrotestosterone (DHT).	juglone	24-31	androgen receptor	Homo sapiens	81-98
23643730-10	2013	Moreover, we found that juglone significantly inhibited the expression levels of androgen receptor (AR) and prostate-specific antigen (PSA) in a dose-dependent manner, as well as abrogated up-regulation of AR and PSA genes with and/or without dihydrotestosterone (DHT).	juglone	24-31	androgen receptor	Homo sapiens	100-102
23643730-10	2013	Moreover, we found that juglone significantly inhibited the expression levels of androgen receptor (AR) and prostate-specific antigen (PSA) in a dose-dependent manner, as well as abrogated up-regulation of AR and PSA genes with and/or without dihydrotestosterone (DHT).	juglone	24-31	kallikrein related peptidase 3	Homo sapiens	108-139
23643730-10	2013	Moreover, we found that juglone significantly inhibited the expression levels of androgen receptor (AR) and prostate-specific antigen (PSA) in a dose-dependent manner, as well as abrogated up-regulation of AR and PSA genes with and/or without dihydrotestosterone (DHT).	juglone	24-31	androgen receptor	Homo sapiens	206-208
23643730-10	2013	Moreover, we found that juglone significantly inhibited the expression levels of androgen receptor (AR) and prostate-specific antigen (PSA) in a dose-dependent manner, as well as abrogated up-regulation of AR and PSA genes with and/or without dihydrotestosterone (DHT).	juglone	24-31	kallikrein related peptidase 3	Homo sapiens	135-138
23643730-11	2013	Take together, our results demonstrated that juglone might induce the apoptosis in LNCaP cell via down-regulation of AR expression.	juglone	45-52	androgen receptor	Homo sapiens	117-119
23593298-8	2013	Moreover, the impact of GSSG recycling was potentiated under oxidative stress conditions, explaining the enormous effect gsr-1(RNAi) knockdown had on juglone tolerance.	juglone	150-157	Glutathione reductase, mitochondrial	Caenorhabditis elegans	121-126
23181283-9	2012	The percentages of early apoptosis of Annexin V-FITC were 5.23%, 7.95%, 10.69%, and 20.92% with the concentrations of juglone (12.5, 25, 50, and 100 micromol/L), respectively.	juglone	118-125	annexin A5	Homo sapiens	38-47
23181283-10	2012	After cells were treated with juglone at the different dose for 24 h, the expression of Bcl-2 was significantly down-regulated and the expression of Bax was significantly up-regulated compared with the control.	juglone	30-37	BCL2 apoptosis regulator	Homo sapiens	88-93
23181283-10	2012	After cells were treated with juglone at the different dose for 24 h, the expression of Bcl-2 was significantly down-regulated and the expression of Bax was significantly up-regulated compared with the control.	juglone	30-37	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152
23002436-11	2012	Our results also show that CL097 induced proline isomerase 1 (Pin1) activation and that juglone, a Pin1 inhibitor, inhibited CL097-mediated priming of fMLF-induced p47phox phosphorylation and superoxide production.	juglone	88-95	inhibitor of growth family member 1	Homo sapiens	164-167
22226931-5	2012	Interestingly, PQQ also stimulated redox cycling of TrxR1 with another quinone substrate, juglone, as much as 13-fold (k(cat)/K(m) increased from 105 min(-1) muM(-1) to 1331 min(-1) muM(-1) for juglone in the presence of 50 muM PQQ, mainly through a lowered apparent K(m) for juglone).	juglone	194-201	thioredoxin reductase 1	Homo sapiens	52-57
22863590-6	2012	AKR enzyme assay indicated that the recombinant AKR7A5 protein exhibited mild substrate specificity towards lawsone and low specificity towards juglone and vitamine K3,  but no activity towards 1, 4-naphthoquinone.	juglone	144-151	aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)	Mus musculus	48-54
22507983-2	2012	The EC(50) value for juglone at 24 h decreased from 28.5 muM to 6.3 muM in the presence of ascorbate.	juglone	21-28	latexin	Homo sapiens	57-60
22507983-2	2012	The EC(50) value for juglone at 24 h decreased from 28.5 muM to 6.3 muM in the presence of ascorbate.	juglone	21-28	latexin	Homo sapiens	68-71
22507983-7	2012	In cells treated with juglone (1-5 muM), a concentration-dependent decrease in cell proliferation was observed.	juglone	22-29	latexin	Homo sapiens	35-38
22505246-0	2012	Phosphoinositol 3-kinase, a novel target molecule for the inhibitory             effects of juglone on TPA-induced cell transformation.	juglone	92-99	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-24
22505246-3	2012	The results showed that TPA- and endothelial growth factor (EGF)-induced anchorage-independent colony formation were suppressed in a dose-dependent manner by treatment of JB6 CI41 mouse skin epidermal cells with juglone (2.5 and 5 microM).	juglone	212-219	epidermal growth factor	Homo sapiens	33-58
22505246-3	2012	The results showed that TPA- and endothelial growth factor (EGF)-induced anchorage-independent colony formation were suppressed in a dose-dependent manner by treatment of JB6 CI41 mouse skin epidermal cells with juglone (2.5 and 5 microM).	juglone	212-219	epidermal growth factor	Homo sapiens	60-63
22226931-5	2012	Interestingly, PQQ also stimulated redox cycling of TrxR1 with another quinone substrate, juglone, as much as 13-fold (k(cat)/K(m) increased from 105 min(-1) muM(-1) to 1331 min(-1) muM(-1) for juglone in the presence of 50 muM PQQ, mainly through a lowered apparent K(m) for juglone).	juglone	194-201	thioredoxin reductase 1	Homo sapiens	52-57
22266044-2	2012	Our previous study showed that juglone inhibited the proliferation of HL-60 cells with an IC50 value ~8 muM.	juglone	31-38	latexin	Homo sapiens	104-107
22226931-5	2012	Interestingly, PQQ also stimulated redox cycling of TrxR1 with another quinone substrate, juglone, as much as 13-fold (k(cat)/K(m) increased from 105 min(-1) muM(-1) to 1331 min(-1) muM(-1) for juglone in the presence of 50 muM PQQ, mainly through a lowered apparent K(m) for juglone).	juglone	90-97	thioredoxin reductase 1	Homo sapiens	52-57
22226931-5	2012	Interestingly, PQQ also stimulated redox cycling of TrxR1 with another quinone substrate, juglone, as much as 13-fold (k(cat)/K(m) increased from 105 min(-1) muM(-1) to 1331 min(-1) muM(-1) for juglone in the presence of 50 muM PQQ, mainly through a lowered apparent K(m) for juglone).	juglone	90-97	PWWP domain containing 3A, DNA repair factor	Homo sapiens	158-164
22226931-5	2012	Interestingly, PQQ also stimulated redox cycling of TrxR1 with another quinone substrate, juglone, as much as 13-fold (k(cat)/K(m) increased from 105 min(-1) muM(-1) to 1331 min(-1) muM(-1) for juglone in the presence of 50 muM PQQ, mainly through a lowered apparent K(m) for juglone).	juglone	90-97	PWWP domain containing 3A, DNA repair factor	Homo sapiens	182-188
22266044-4	2012	The generation of ROS was about 2 to 8-fold as compared to control cell after treatment with juglone (2, 4 and 8 muM) for 24 h. The glutathione (GSH) depletion was consistent with ROS generation after treatment with juglone.	juglone	93-100	latexin	Homo sapiens	113-116
22266044-5	2012	Reversal of apoptosis in antioxidants (NAC and catalase) pretreated cells indicated the involvement of ROS in juglone-induced apoptosis.	juglone	110-117	synuclein alpha	Homo sapiens	39-55
22266044-6	2012	The cleavage of PARP and procaspase-3 and -9, loss of mitochondrial membrane potential ( Psim), and release of cytochrome c (Cyt c) and Smac induced by juglone were significantly blocked by NAC.	juglone	152-159	poly(ADP-ribose) polymerase 1	Homo sapiens	16-20
22266044-6	2012	The cleavage of PARP and procaspase-3 and -9, loss of mitochondrial membrane potential ( Psim), and release of cytochrome c (Cyt c) and Smac induced by juglone were significantly blocked by NAC.	juglone	152-159	caspase 3	Homo sapiens	25-44
22266044-6	2012	The cleavage of PARP and procaspase-3 and -9, loss of mitochondrial membrane potential ( Psim), and release of cytochrome c (Cyt c) and Smac induced by juglone were significantly blocked by NAC.	juglone	152-159	cytochrome c, somatic	Homo sapiens	111-123
22266044-6	2012	The cleavage of PARP and procaspase-3 and -9, loss of mitochondrial membrane potential ( Psim), and release of cytochrome c (Cyt c) and Smac induced by juglone were significantly blocked by NAC.	juglone	152-159	cytochrome c, somatic	Homo sapiens	125-130
22266044-6	2012	The cleavage of PARP and procaspase-3 and -9, loss of mitochondrial membrane potential ( Psim), and release of cytochrome c (Cyt c) and Smac induced by juglone were significantly blocked by NAC.	juglone	152-159	diablo IAP-binding mitochondrial protein	Homo sapiens	136-140
22266044-6	2012	The cleavage of PARP and procaspase-3 and -9, loss of mitochondrial membrane potential ( Psim), and release of cytochrome c (Cyt c) and Smac induced by juglone were significantly blocked by NAC.	juglone	152-159	synuclein alpha	Homo sapiens	190-193
22266044-7	2012	NAC also prevented the inhibition the phosphorylation of Akt and mTOR proteins by juglone.	juglone	82-89	synuclein alpha	Homo sapiens	0-3
22266044-7	2012	NAC also prevented the inhibition the phosphorylation of Akt and mTOR proteins by juglone.	juglone	82-89	AKT serine/threonine kinase 1	Homo sapiens	57-60
22266044-7	2012	NAC also prevented the inhibition the phosphorylation of Akt and mTOR proteins by juglone.	juglone	82-89	mechanistic target of rapamycin kinase	Homo sapiens	65-69
21903399-4	2011	The juglone conjugated with oleic acid (C18:1-acyl juglone) showed the strongest inhibition of DNA replicative pol alpha activity and human colon carcinoma (HCT116) cell growth in 10 synthesized 5-O-acyl juglones.	juglone	4-11	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	111-120
21443524-8	2012	Here, we show that inhibition of Pin1 by its selective inhibitor juglone leads to up-regulation of cyclinD1, phospho-tau, and caspase 3, producing apoptosis in cultured rat hippocampal neurons.	juglone	65-72	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	33-37
21443524-8	2012	Here, we show that inhibition of Pin1 by its selective inhibitor juglone leads to up-regulation of cyclinD1, phospho-tau, and caspase 3, producing apoptosis in cultured rat hippocampal neurons.	juglone	65-72	cyclin D1	Rattus norvegicus	99-107
21443524-8	2012	Here, we show that inhibition of Pin1 by its selective inhibitor juglone leads to up-regulation of cyclinD1, phospho-tau, and caspase 3, producing apoptosis in cultured rat hippocampal neurons.	juglone	65-72	caspase 3	Rattus norvegicus	126-135
21051667-6	2011	Inhibition of Pin1 in BAECs by juglone or by dominant negative Pin1 increases basal and agonist-stimulated NO release from the cells, whereas overexpression of wild-type Pin1 in BAECs suppresses basal and agonist-stimulated NO production.	juglone	31-38	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Bos taurus	14-18
21680504-7	2011	Juglone, a natural inhibitor of Pin1, inhibited HCV propagation by inhibiting the interplay between the Pin1 and HCV NS5A/NS5B proteins.	juglone	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	32-36
21680504-7	2011	Juglone, a natural inhibitor of Pin1, inhibited HCV propagation by inhibiting the interplay between the Pin1 and HCV NS5A/NS5B proteins.	juglone	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	104-108
21454638-6	2011	In contrast, the treatment of HepG2 cells with Pin1 siRNA or the Pin1 inhibitor Juglone suppressed these events.	juglone	80-87	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	65-69
21982843-8	2011	Reversal of apoptosis in both NAC- and Tempol-pretreated cells indicates the involvement of both ROS generation and GSH depletion in plumbagin- and juglone-induced apoptosis.	juglone	148-155	X-linked Kx blood group	Homo sapiens	30-33
20956805-7	2010	Inhibition of Pin1 activity with juglone or with a specific peptide inhibitor abrogated TNF-alpha-induced priming of neutrophil ROS production induced by N-formyl-methionyl-leucyl-phenylalanine peptide (fMLF).	juglone	33-40	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	14-18
21172426-5	2011	TrxR2 displayed strikingly lower activity with dithionitrobenzoic acid (DTNB), lipoamide, and the quinone substrate juglone compared to TrxR1, and TrxR2 could not reduce lipoic acid.	juglone	116-123	thioredoxin reductase 2	Homo sapiens	0-5
19815401-9	2011	After cells were treated with juglone at the same dose for 24h, the level of ROS was significantly higher, the expression of Bcl-2 was significantly down-regulated and the expression of Bax was significantly up-regulated compared to the control.	juglone	30-37	BCL2 apoptosis regulator	Homo sapiens	125-130
19815401-9	2011	After cells were treated with juglone at the same dose for 24h, the level of ROS was significantly higher, the expression of Bcl-2 was significantly down-regulated and the expression of Bax was significantly up-regulated compared to the control.	juglone	30-37	BCL2 associated X, apoptosis regulator	Homo sapiens	186-189
19815401-12	2011	In conclusion, juglone can induce apoptosis in SGC-7901 cells through a mitochondrial pathway that seems to be mediated by the generation of ROS and a reduction in the Bcl-2/Bax ratio.	juglone	15-22	BCL2 apoptosis regulator	Homo sapiens	168-173
19815401-12	2011	In conclusion, juglone can induce apoptosis in SGC-7901 cells through a mitochondrial pathway that seems to be mediated by the generation of ROS and a reduction in the Bcl-2/Bax ratio.	juglone	15-22	BCL2 associated X, apoptosis regulator	Homo sapiens	174-177
22174645-0	2011	Expression patterns of glutathione transferase gene (GstI) in maize seedlings under juglone-induced oxidative stress.	juglone	84-91	Omega-hydroxypalmitate O-feruloyl transferase	Zea mays	35-46
22174645-0	2011	Expression patterns of glutathione transferase gene (GstI) in maize seedlings under juglone-induced oxidative stress.	juglone	84-91	glutathione S-transferase 1	Zea mays	53-57
22174645-5	2011	Furthermore, the effect of juglone-induced oxidative stress on glutathione transferase (GstI) gene expression patterns in maize seedlings was recorded.	juglone	27-34	Omega-hydroxypalmitate O-feruloyl transferase	Zea mays	75-86
22174645-5	2011	Furthermore, the effect of juglone-induced oxidative stress on glutathione transferase (GstI) gene expression patterns in maize seedlings was recorded.	juglone	27-34	glutathione S-transferase 1	Zea mays	88-92
22174645-6	2011	It was revealed that 4-day juglone treatment significantly stimulated the transcriptional activity of GstI in maize seedlings compared to control plants.	juglone	27-34	glutathione S-transferase 1	Zea mays	102-106
20956805-7	2010	Inhibition of Pin1 activity with juglone or with a specific peptide inhibitor abrogated TNF-alpha-induced priming of neutrophil ROS production induced by N-formyl-methionyl-leucyl-phenylalanine peptide (fMLF).	juglone	33-40	tumor necrosis factor	Homo sapiens	88-97
20655907-9	2010	The percentages of Annexin V-FITC-positive/PI negative cells were 7.81%, 35.46%, 49.11% and 66.02% with the concentrations of Juglone (0, 0.5, 1.0 and 1.5 microg/ml).	juglone	126-133	annexin A5	Homo sapiens	19-28
20655907-10	2010	Juglone could induce the mitochondrial membrane potential (DeltaPsim) loss, which preceded release of cytochrome c (Cyt c), Smac and apoptosis inducing factor (AIF) to cell cytoplasm.	juglone	0-7	cytochrome c, somatic	Homo sapiens	102-114
20655907-10	2010	Juglone could induce the mitochondrial membrane potential (DeltaPsim) loss, which preceded release of cytochrome c (Cyt c), Smac and apoptosis inducing factor (AIF) to cell cytoplasm.	juglone	0-7	cytochrome c, somatic	Homo sapiens	116-121
20655907-10	2010	Juglone could induce the mitochondrial membrane potential (DeltaPsim) loss, which preceded release of cytochrome c (Cyt c), Smac and apoptosis inducing factor (AIF) to cell cytoplasm.	juglone	0-7	diablo IAP-binding mitochondrial protein	Homo sapiens	124-128
20655907-10	2010	Juglone could induce the mitochondrial membrane potential (DeltaPsim) loss, which preceded release of cytochrome c (Cyt c), Smac and apoptosis inducing factor (AIF) to cell cytoplasm.	juglone	0-7	apoptosis inducing factor mitochondria associated 1	Homo sapiens	133-158
20655907-10	2010	Juglone could induce the mitochondrial membrane potential (DeltaPsim) loss, which preceded release of cytochrome c (Cyt c), Smac and apoptosis inducing factor (AIF) to cell cytoplasm.	juglone	0-7	apoptosis inducing factor mitochondria associated 1	Homo sapiens	160-163
20655907-13	2010	And the apoptosis induced by Juglone was blocked by z-LEHD-fmk, a caspase-9 inhibitor.	juglone	29-36	caspase 9	Homo sapiens	66-75
20655907-14	2010	Those results of our studies demonstrated that Juglone-induced mitochondrial dysfunction in HL-60 cells trigger events responsible for mitochondrial-dependent apoptosis pathways and the elevated ratio of Bax/Bcl-2 was also probably involved in this effect.	juglone	47-54	BCL2 associated X, apoptosis regulator	Homo sapiens	204-207
20655907-14	2010	Those results of our studies demonstrated that Juglone-induced mitochondrial dysfunction in HL-60 cells trigger events responsible for mitochondrial-dependent apoptosis pathways and the elevated ratio of Bax/Bcl-2 was also probably involved in this effect.	juglone	47-54	BCL2 apoptosis regulator	Homo sapiens	208-213
20307651-12	2010	Intraperitoneal injection of juglone (a Pin1 inhibitor) for 3weeks (1mg/kg, two times a week) significantly suppressed neointimal formation induced by wire injury.	juglone	29-36	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	40-44
20382008-5	2010	The expression of hsp-16.1 and hsp-16.2 in EGCG-treated worms (N2), as quantified by real-time PCR, was significantly lower under oxidative stress induced by juglone than in controls without EGCG.	juglone	158-165	Heat shock protein Hsp-16.1/Hsp-16.11	Caenorhabditis elegans	18-26
20382008-5	2010	The expression of hsp-16.1 and hsp-16.2 in EGCG-treated worms (N2), as quantified by real-time PCR, was significantly lower under oxidative stress induced by juglone than in controls without EGCG.	juglone	158-165	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	31-39
20479004-8	2010	Moreover, PD98059, a specific inhibitor of MEK1/2, and juglone, a potent Pin1 inhibitor, significantly suppressed the TPA-induced expression of E2F-4 as well as Egr-1 transcription factors, which control LC-3 gene expression.	juglone	55-62	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	73-77
20479004-8	2010	Moreover, PD98059, a specific inhibitor of MEK1/2, and juglone, a potent Pin1 inhibitor, significantly suppressed the TPA-induced expression of E2F-4 as well as Egr-1 transcription factors, which control LC-3 gene expression.	juglone	55-62	E2F transcription factor 4	Homo sapiens	144-149
20479004-8	2010	Moreover, PD98059, a specific inhibitor of MEK1/2, and juglone, a potent Pin1 inhibitor, significantly suppressed the TPA-induced expression of E2F-4 as well as Egr-1 transcription factors, which control LC-3 gene expression.	juglone	55-62	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	204-208
19597959-5	2010	Silencing or deletion of DAF-16 prevented the juglone-induced adaptations.	juglone	46-53	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	25-31
20153715-6	2010	EGFR activation by plumbagin, juglone and menadione was attenuated by a superoxide dismutase mimetic, indicating that ROS-related mechanisms contribute to EGFR activation by these naphthoquinones.	juglone	30-37	epidermal growth factor receptor	Homo sapiens	0-4
20153715-6	2010	EGFR activation by plumbagin, juglone and menadione was attenuated by a superoxide dismutase mimetic, indicating that ROS-related mechanisms contribute to EGFR activation by these naphthoquinones.	juglone	30-37	epidermal growth factor receptor	Homo sapiens	155-159
20047646-0	2010	The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model.	juglone	20-27	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	4-9
20179161-7	2010	Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells.	juglone	58-65	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	76-80
20179161-7	2010	Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells.	juglone	58-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	163-168
20179161-7	2010	Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells.	juglone	58-65	epidermal growth factor	Homo sapiens	198-201
20047646-0	2010	The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model.	juglone	20-27	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	63-68
20047646-2	2010	Juglone (5-hydroxy-1,4-naphthoquinone) is a natural inhibitor of Pin 1 with anti-inflammatory and antifibrotic properties.	juglone	0-7	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	65-70
20047646-2	2010	Juglone (5-hydroxy-1,4-naphthoquinone) is a natural inhibitor of Pin 1 with anti-inflammatory and antifibrotic properties.	juglone	9-37	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	65-70
20047646-4	2010	RESULTS: After 2 weeks of UUO, immunoblot analyses demonstrated that juglone (0.25 and 1 mg/kg/24 h) inhibited the deposition of matrix (alpha-smooth muscle actin (SMA), collagen type III and vimentin) and the activation of signaling pathways involved in fibrogenesis (phospho-smad2) and stress response (phospho-heat shock protein (HSP)27).	juglone	69-76	SMAD family member 2	Rattus norvegicus	277-282
20047646-4	2010	RESULTS: After 2 weeks of UUO, immunoblot analyses demonstrated that juglone (0.25 and 1 mg/kg/24 h) inhibited the deposition of matrix (alpha-smooth muscle actin (SMA), collagen type III and vimentin) and the activation of signaling pathways involved in fibrogenesis (phospho-smad2) and stress response (phospho-heat shock protein (HSP)27).	juglone	69-76	heat shock protein family B (small) member 1	Rattus norvegicus	305-339
20047646-10	2010	The antifibrotic effects of juglone may result from the inhibition of smad2 and oxidative stress.	juglone	28-35	SMAD family member 2	Rattus norvegicus	70-75
19846884-8	2009	Treatment of RA mice with juglone, a chemical inhibitor of Pin1, significantly reduced RA progress and COX-2 expression in the ankle tissues.	juglone	26-33	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	59-63
19846884-8	2009	Treatment of RA mice with juglone, a chemical inhibitor of Pin1, significantly reduced RA progress and COX-2 expression in the ankle tissues.	juglone	26-33	prostaglandin-endoperoxide synthase 2	Mus musculus	103-108
19846884-9	2009	Moreover, juglone dose dependently decreased the basal COX-2 expression in primary cultured chondrocytes from RA patients.	juglone	10-17	prostaglandin-endoperoxide synthase 2	Mus musculus	55-60
19502098-4	2009	Pin1 was inhibited with juglone (5-hydroxy-1,4-naphthalenedione) or Pin1 specific siRNA and its influence on cell cycle checkpoint distribution was assessed by FACS analysis.	juglone	24-31	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
19502098-4	2009	Pin1 was inhibited with juglone (5-hydroxy-1,4-naphthalenedione) or Pin1 specific siRNA and its influence on cell cycle checkpoint distribution was assessed by FACS analysis.	juglone	33-63	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
19502098-7	2009	Inhibition of HNSCC cells with juglone or Pin1 siRNA induced the cell cycle inhibitor p21(WAF1/Cip1) with a concomitant reduction of cells in G2/M and an increased fraction of cells with fragmented DNA.	juglone	31-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-89
19502098-7	2009	Inhibition of HNSCC cells with juglone or Pin1 siRNA induced the cell cycle inhibitor p21(WAF1/Cip1) with a concomitant reduction of cells in G2/M and an increased fraction of cells with fragmented DNA.	juglone	31-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	90-94
19502098-7	2009	Inhibition of HNSCC cells with juglone or Pin1 siRNA induced the cell cycle inhibitor p21(WAF1/Cip1) with a concomitant reduction of cells in G2/M and an increased fraction of cells with fragmented DNA.	juglone	31-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-99
19890497-6	2009	Many inhibitors of Pin1 have been discovered, including several classes of designed inhibitors (alkene isosteres, reduced amides, indanyl ketones) and natural products (juglone, pepticinnamin E analogues, PiB and its derivatives obtained from a library screen).	juglone	169-176	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	19-23
19671742-4	2009	Pin1, a peptidyl prolyl isomerase, was consistently overexpressed in TAMR-MCF-7 cells, and c-Jun/activator protein-1-dependent VEGF transcription in TAMR-MCF-7 cells was almost completely inhibited by Pin1 siRNA and by the Pin1 inhibitor juglone.	juglone	238-245	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
19682488-2	2009	Exposure to the redox-cycling quinone juglone upon exit from dauer diapause results in defective egg-laying (Egl phenotype) in the pcm-1 mutants only.	juglone	38-45	Protein-L-isoaspartate O-methyltransferase	Caenorhabditis elegans	131-136
19682488-7	2009	Furthermore, we have demonstrated that a mutation in the gene encoding the insulin-like receptor DAF-2 suppresses the Egl phenotype in pcm-1 mutants treated with juglone.	juglone	162-169	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	97-102
19682488-7	2009	Furthermore, we have demonstrated that a mutation in the gene encoding the insulin-like receptor DAF-2 suppresses the Egl phenotype in pcm-1 mutants treated with juglone.	juglone	162-169	Protein-L-isoaspartate O-methyltransferase	Caenorhabditis elegans	135-140
19520166-3	2009	Indeed, in the presence of the specific Pin1 inhibitor juglone, Abeta-induced Tau(Thr231)dephosphorylation is prevented.	juglone	55-62	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	40-44
19458071-6	2009	Importantly, inhibition of Pin1 function with the pharmacologic inhibitor juglone or with Pin1-specific shRNA led to cytoplasmic relocalization of endogenous c-Rel in human lymphoma-derived cell lines, markedly interfered with lymphoma cell proliferation, and suppressed endogenous Rel/NF-kappaB-dependent gene expression.	juglone	74-81	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	27-31
19458071-6	2009	Importantly, inhibition of Pin1 function with the pharmacologic inhibitor juglone or with Pin1-specific shRNA led to cytoplasmic relocalization of endogenous c-Rel in human lymphoma-derived cell lines, markedly interfered with lymphoma cell proliferation, and suppressed endogenous Rel/NF-kappaB-dependent gene expression.	juglone	74-81	REL proto-oncogene, NF-kB subunit	Homo sapiens	158-163
18539601-12	2008	Since juglone affected cell cycle progression at several levels, more specific drugs need to be developed for studies of Pin1 function in vivo.	juglone	6-13	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	121-125
19252938-4	2009	RNA-interference for DAF-16 in CL2070 blocked the juglone-induced HSP-16.2 expression and the increase in glutathione levels.	juglone	50-57	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	21-27
19252938-4	2009	RNA-interference for DAF-16 in CL2070 blocked the juglone-induced HSP-16.2 expression and the increase in glutathione levels.	juglone	50-57	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	66-74
19252938-2	2009	In transgenic Caenorhabditis elegans expressing green fluorescent protein (GFP) under control of the hsp-16.2 promoter (CL2070) 100 muM of the ROS-generator juglone induced GFP-expression.	juglone	157-164	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	101-109
19085685-3	2009	The expression of HSP-16.2 (induced by the pro-oxidant juglone) and the intracellular levels of H (2)O (2) were inhibited by EGCG treatment.	juglone	55-62	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	18-26
17720236-5	2007	METHODS: The Pin1 inhibitor juglone (5-hydroxy-1,4-naphthoquinone) was administered to allergen-sensitized and allergen-challenged Brown Norway rats.	juglone	28-35	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	13-17
17901115-9	2008	To investigate the function of GSTO-1 in vivo, transgenic animals overexpressing GSTO-1 were generated exhibiting an increased resistance to juglone-, paraquat-, and cumene hydroperoxide-induced oxidative stress.	juglone	141-148	Glutathione transferase omega-1	Caenorhabditis elegans	81-87
17720236-5	2007	METHODS: The Pin1 inhibitor juglone (5-hydroxy-1,4-naphthoquinone) was administered to allergen-sensitized and allergen-challenged Brown Norway rats.	juglone	37-65	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Rattus norvegicus	13-17