PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	3-hydroxyphloretin	140-158	sucrase-isomaltase	Homo sapiens	194-211
17379263-4	2007	The active constituents were identified as 3-hydroxyphloretin (7) and catechol (9); they exhibited potent hydroxyl radical-scavenging (IC(50) values, 0.6 and 1.1 microM) and cellular tyrosinase-reducing activities (IC(50) values, 32 and 22 microM) in human epidermal melanocytes.	3-hydroxyphloretin	43-61	tyrosinase	Homo sapiens	183-193
17379263-7	2007	In a kinetic analysis of mushroom tyrosinase, 3-hydroxyphloretin (7) was a competitive inhibitor.	3-hydroxyphloretin	46-64	tyrosinase	Homo sapiens	34-44
17379263-9	2007	Thus, 3-hydroxyphloretin (7) and catechol (9) were the most active constituents from the Formosan apple; they exhibited anti-oxidant and tyrosinase reducing activities, suggesting their possible use as cosmetic agents.	3-hydroxyphloretin	6-24	tyrosinase	Homo sapiens	137-147
16595910-13	2006	Phloretin (5), 3-hydroxyphloretin (6), and quercetin (7) showed better inhibition of MMP-1 production in fibroblast cells.	3-hydroxyphloretin	15-33	matrix metallopeptidase 1	Homo sapiens	85-90