PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 11141352-9 2001 Hepatic myeloperoxidase activity increased by 1.1-, 2.1-, or 6.7-fold by lindane, iron, or their combined administration, respectively. Hexachlorocyclohexane 73-80 myeloperoxidase Rattus norvegicus 8-23 10993823-8 2000 Therefore, our results are consistent with the hypothesis that alpha-, delta-, and gamma-HCH inhibited steroidogenesis by reducing StAR protein expression, an action that may contribute to the pathogenesis of lindane-induced reproductive dysfunction. Hexachlorocyclohexane 209-216 steroidogenic acute regulatory protein Mus musculus 131-135 10856602-9 2000 In comparison, when NP was given in combination with gamma-HCH, Vtg levels was significantly reduced, compared to NP treatment alone. Hexachlorocyclohexane 53-62 vitellogenin Salmo salar 64-67 11097267-12 2000 Lindane (0.15 mM)-induced Ca2+ release was not reduced by inhibiting phospholipase C with 2 microM U73122, but was inhibited by 70% by the phospholipase A2 inhibitor aristolochic acid (40 microM). Hexachlorocyclohexane 0-7 phospholipase A2 group IB Canis lupus familiaris 139-155 10964798-4 2000 We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein. Hexachlorocyclohexane 57-64 steroidogenic acute regulatory protein Mus musculus 193-223 10964798-4 2000 We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein. Hexachlorocyclohexane 57-64 steroidogenic acute regulatory protein Mus musculus 225-229 10653519-3 2000 Therefore, studies were performed to determine if the organochlorine pesticides, lindane and dieldrin, activate neutrophils to produce O2- by a mechanism that requires PLA2. Hexachlorocyclohexane 81-88 phospholipase A2 group IB Homo sapiens 168-172 10653519-5 2000 Significant release of 3H-AA was seen in neutrophils stimulated with dieldrin or lindane in calcium-free medium and in the presence of the intracellular calcium chelator BAPTA-AM, suggesting that these agents stimulate a PLA2 that does not require calcium for activation. Hexachlorocyclohexane 81-88 phospholipase A2 group IB Homo sapiens 221-225 10653519-7 2000 These data suggest that dieldrin and lindane stimulate O2- production by a mechanism that involves PLA2. Hexachlorocyclohexane 37-44 phospholipase A2 group IB Homo sapiens 99-103 10653519-9 2000 This suggests that more than one isoform of PLA2 is activated by dieldrin and by lindane, and that one isoform is calcium-dependent. Hexachlorocyclohexane 81-88 phospholipase A2 group IB Homo sapiens 44-48 10518488-9 1999 Treatment of cultured chick embryos with lindane, which diminishes gap junctional communication, frequently unbiased normal LR asymmetry of Shh and Nodal gene expression, causing the normally left-sided program to be recapitulated symmetrically on the right side of the embryo. Hexachlorocyclohexane 41-48 sonic hedgehog Gallus gallus 140-143 10518488-9 1999 Treatment of cultured chick embryos with lindane, which diminishes gap junctional communication, frequently unbiased normal LR asymmetry of Shh and Nodal gene expression, causing the normally left-sided program to be recapitulated symmetrically on the right side of the embryo. Hexachlorocyclohexane 41-48 nodal growth differentiation factor Gallus gallus 148-153 10097797-7 1999 When the rats were treated with hexachlorocyclohexane during critical stages of testicular development (6th-30th day) and responses were evaluated on the 46th day of age, elevations in the levels of testicular lipid peroxidation and H2O2 along with reduction in levels of superoxide dismutase, catalase and ascorbic acid were observed. Hexachlorocyclohexane 32-53 catalase Rattus norvegicus 294-302 10613396-8 1999 Additionally, the phospholipase A2 inhibitor and antioxidant quinacrine increased the ED50 for contraction force inhibition to 84.5 microM lindane. Hexachlorocyclohexane 139-146 phospholipase A2 group IB Rattus norvegicus 18-34 10426785-0 1999 Effect of lindane and phenobarbital on cyclooxygenase-2 expression and prostanoid synthesis by Kupffer cells. Hexachlorocyclohexane 10-17 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 39-55 10426785-5 1999 Similarly, PB, which shares several effects with lindane in rat liver, also clearly induced COX-2. Hexachlorocyclohexane 49-56 cytochrome c oxidase II, mitochondrial Rattus norvegicus 92-97 9989472-2 1999 for 7, 15 and 30 days) to hexachlorocyclohexane (HCH) on open-field behaviour and activities of cerebral Na+,K+-ATPase, Mg2+-ATPase and acetylcholinesterase (AChE) of rat was evaluated. Hexachlorocyclohexane 26-47 acetylcholinesterase Rattus norvegicus 158-162 9989472-2 1999 for 7, 15 and 30 days) to hexachlorocyclohexane (HCH) on open-field behaviour and activities of cerebral Na+,K+-ATPase, Mg2+-ATPase and acetylcholinesterase (AChE) of rat was evaluated. Hexachlorocyclohexane 49-52 acetylcholinesterase Rattus norvegicus 136-156 9989472-2 1999 for 7, 15 and 30 days) to hexachlorocyclohexane (HCH) on open-field behaviour and activities of cerebral Na+,K+-ATPase, Mg2+-ATPase and acetylcholinesterase (AChE) of rat was evaluated. Hexachlorocyclohexane 49-52 acetylcholinesterase Rattus norvegicus 158-162 9879810-5 1998 In fact, when effects of lindane and heptachlor were compared we observed that lindane produced: (a) greater increases in ALA-S activity (six fold vs four fold), both with respect to dimethyl sulphoxide (DMSO) controls (3.8+/-0.3 nmol ALA/g liver per h); (b) earlier ALA-S response (1.5 h vs 4 h); (c) responses at lower doses (0.3 mg/egg vs 1 mg/egg). Hexachlorocyclohexane 79-86 5'-aminolevulinate synthase 1 Homo sapiens 122-127 9879810-5 1998 In fact, when effects of lindane and heptachlor were compared we observed that lindane produced: (a) greater increases in ALA-S activity (six fold vs four fold), both with respect to dimethyl sulphoxide (DMSO) controls (3.8+/-0.3 nmol ALA/g liver per h); (b) earlier ALA-S response (1.5 h vs 4 h); (c) responses at lower doses (0.3 mg/egg vs 1 mg/egg). Hexachlorocyclohexane 79-86 5'-aminolevulinate synthase 1 Homo sapiens 267-272 9879810-0 1998 Effect of lindane and heptachlor on delta-aminolaevulinate synthase and its regulation. Hexachlorocyclohexane 10-17 5'-aminolevulinate synthase 1 Homo sapiens 36-67 9879810-6 1998 (2) The increase in ALA-S activity produced by lindane or heptachlor is an induction and not an activation process since it depends on protein synthesis and the drugs per se have no effect. Hexachlorocyclohexane 47-54 5'-aminolevulinate synthase 1 Homo sapiens 20-25 9879810-3 1998 The results indicated the following: (1) Lindane and heptachlor produced increases in ALA-S activity; this effect was dependent on the drug dose, the time of treatment, and the development of the animal, the maximum response being obtained prior to hatching. Hexachlorocyclohexane 41-48 5'-aminolevulinate synthase 1 Homo sapiens 86-91 9879810-4 1998 Lindane was observed to have a greater effect on ALA-S than heptachlor. Hexachlorocyclohexane 0-7 5'-aminolevulinate synthase 1 Homo sapiens 49-54 9879810-9 1998 (4) Exogenous haem was able to prevent or decrease the induction of ALA-S elicited by both pesticides, thus showing that lindane or heptachlor-induced ALA-S respond to haem regulation. Hexachlorocyclohexane 121-128 5'-aminolevulinate synthase 1 Homo sapiens 68-73 9879810-9 1998 (4) Exogenous haem was able to prevent or decrease the induction of ALA-S elicited by both pesticides, thus showing that lindane or heptachlor-induced ALA-S respond to haem regulation. Hexachlorocyclohexane 121-128 5'-aminolevulinate synthase 1 Homo sapiens 151-156 9806590-2 1998 The extent of modulation of TP53 and CDKN1A is significantly reduced in the presence of the gap junction inhibitor lindane and in irradiated low-density cell populations. Hexachlorocyclohexane 115-122 tumor protein p53 Homo sapiens 28-32 9865422-5 1998 Administration of HCH (technical) to rats at 5 mg/kg, orally, 5 days a week for 1, 2 and 3 months caused marked increase in erythrocyte membrane fluidity, osmotic fragility and decrease in levels of Na+, K(+)-ATPase, acetylcholinesterase in erythrocytes and glutathione in blood. Hexachlorocyclohexane 18-21 acetylcholinesterase Rattus norvegicus 217-237 9806590-2 1998 The extent of modulation of TP53 and CDKN1A is significantly reduced in the presence of the gap junction inhibitor lindane and in irradiated low-density cell populations. Hexachlorocyclohexane 115-122 cyclin dependent kinase inhibitor 1A Homo sapiens 37-43 9733020-4 1998 The administration of lindane to hyperthyroid animals led to a further increase in the molecular activity of NADPH-cytochrome P450 reductase and in the O2.- production/SOD activity ratio, and decrease of hepatic alpha-tocopherol content, in a magnitude exceeding the sum of effects elicited by the separate treatments, as previously reported for reduced glutathione depletion. Hexachlorocyclohexane 22-29 cytochrome p450 oxidoreductase Rattus norvegicus 109-140 9838884-0 1998 Effect of hexachlorocyclohexane on hsp26 expression in transgenic Drosophila melanogaster. Hexachlorocyclohexane 10-31 Heat shock protein 26 Drosophila melanogaster 35-40 9838884-1 1998 Hexachlorocyclohexane (HCH) at different concentrations (0.5 to 5.0 ng/ml) mixed with food was fed to third instar larvae of hsp26-lacZ transgenic Drosophila for 2 hr and hsp26 gene expression was examined by beta-galactosidase staining. Hexachlorocyclohexane 0-21 Heat shock protein 26 Drosophila melanogaster 125-130 9838884-1 1998 Hexachlorocyclohexane (HCH) at different concentrations (0.5 to 5.0 ng/ml) mixed with food was fed to third instar larvae of hsp26-lacZ transgenic Drosophila for 2 hr and hsp26 gene expression was examined by beta-galactosidase staining. Hexachlorocyclohexane 0-21 Heat shock protein 26 Drosophila melanogaster 171-176 9838884-1 1998 Hexachlorocyclohexane (HCH) at different concentrations (0.5 to 5.0 ng/ml) mixed with food was fed to third instar larvae of hsp26-lacZ transgenic Drosophila for 2 hr and hsp26 gene expression was examined by beta-galactosidase staining. Hexachlorocyclohexane 0-21 beta galactosidase Drosophila melanogaster 209-227 9588346-8 1998 Concentrations of insulin in serum were markedly increased in ewes given dimethoate, lindane, trifluralin, triallate, and pentachlorophenol, and concentrations of estradiol were also significantly increased in ewes given lindane and trifluralin. Hexachlorocyclohexane 85-92 insulin Homo sapiens 18-25 9588346-8 1998 Concentrations of insulin in serum were markedly increased in ewes given dimethoate, lindane, trifluralin, triallate, and pentachlorophenol, and concentrations of estradiol were also significantly increased in ewes given lindane and trifluralin. Hexachlorocyclohexane 221-228 insulin Homo sapiens 18-25 9475050-1 1997 Effects of 1,1,1,-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) and lindane were studied on gamma glutamyl transpeptidase (GGT) activity in different tissues of the lymphoid system in rats. Hexachlorocyclohexane 70-77 gamma-glutamyltransferase 1 Rattus norvegicus 94-123 9590437-8 1998 The GABA(A) receptor agonist muscimol (50 microM) also protected the THIP-treated cultures against lindane-induced cytotoxicity. Hexachlorocyclohexane 99-106 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 4-11 9590437-12 1998 It is suggested that the cytotoxic effects of lindane in THIP-treated cerebellar granule neurons are primarily related to an action of lindane on GABA(B) receptors and to a lesser extent on inducible low-affinity, benzodiazepine insensitive GABA(A) receptors. Hexachlorocyclohexane 46-53 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 241-248 9553992-4 1998 D-CPPene, MK-801 and NBQX produced a marked increase of CD50 values of lindane for clonic convulsions. Hexachlorocyclohexane 71-78 intercellular adhesion molecule 5, telencephalin Mus musculus 56-60 9475050-1 1997 Effects of 1,1,1,-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) and lindane were studied on gamma glutamyl transpeptidase (GGT) activity in different tissues of the lymphoid system in rats. Hexachlorocyclohexane 70-77 gamma-glutamyltransferase 1 Rattus norvegicus 125-128 9475050-2 1997 DDT (100 or 200 ppm) and lindane (30 or 80 ppm) exposure for 8 weeks suppressed the GGT activity in a dose dependent manner in thymus and macrophage. Hexachlorocyclohexane 25-32 gamma-glutamyltransferase 1 Rattus norvegicus 84-87 9475050-4 1997 Lindane suppressed GGT activity at both 30 or 80 ppm dose levels, while DDT reduced the GGT activity at 200 ppm but not at 100 ppm exposure in lymphocyte. Hexachlorocyclohexane 0-7 gamma-glutamyltransferase 1 Rattus norvegicus 19-22 9057899-2 1997 One day after lindane treatment, a significant enhancement in the oxidative stress status of the liver was observed, characterized by an increase in thiobarbituric acid reactants production and in the microsomal generation of superoxide radical (O.-2) coupled to cytochrome P450 induction, and a decrement in the activity of superoxide dismutase (SOD) and catalase. Hexachlorocyclohexane 14-21 catalase Rattus norvegicus 356-364 9171990-9 1997 Hexachlorocyclohexane reduced [3H]5 alpha-DHT binding to hSHBG by 20%, but the stereospecific effects observed with ABP did not occur. Hexachlorocyclohexane 0-21 sex hormone binding globulin Homo sapiens 57-62 10072926-1 1997 AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. Hexachlorocyclohexane 95-102 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 50-55 10072926-6 1997 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Hexachlorocyclohexane 16-23 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-37 10072926-8 1997 CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist-lindane. Hexachlorocyclohexane 88-95 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 26-31 9007031-11 1997 The finding that delta-HCH was more toxic than lindane may be correlated to the differences between the isomers with regard to the action on the different Ca2+ pools. Hexachlorocyclohexane 47-54 carbonic anhydrase 2 Rattus norvegicus 155-158 9171990-6 1997 The binding of [3H]5 alpha-DHT to ABP was inhibited 70% by the delta-isomer of hexachlorocyclohexane, but the gamma-isomer did not reduce binding significantly. Hexachlorocyclohexane 79-100 sex hormone binding globulin Homo sapiens 34-37 23899150-13 1997 In rat and hum an cells, lindane treatm ent strongly induces CYP2B and CYP3A m RNA levels, whereas pentachlorophenol treatm ent induces CYP1A, CYP2B and CYP3A. Hexachlorocyclohexane 25-32 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 71-76 9291495-1 1997 An in vitro orthodromic stimulation technique was used to examine the effects of lindane and long-term potentiation (LTP) inducing stimuli, alone or in combination, on the excitatory afferent terminal of CA1 pyramidal cells and on recurrent collateral evoked inhibition using the rat hippocampal slice model. Hexachlorocyclohexane 81-88 carbonic anhydrase 1 Rattus norvegicus 204-207 9007031-0 1997 The mechanism for hexachlorocyclohexane-induced cytotoxicity and changes in intracellular Ca2+ homeostasis in cultured cerebellar granule neurons is different for the gamma- and delta-isomers. Hexachlorocyclohexane 18-39 carbonic anhydrase 2 Rattus norvegicus 90-93 9007031-13 1997 On the contrary, lindane had little effect on these Ca2+ pools but affected primarily dantrolene-sensitive intracellular Ca2+ stores. Hexachlorocyclohexane 17-24 carbonic anhydrase 2 Rattus norvegicus 121-124 9007031-15 1997 In contrast, the toxic action of lindane may be primarily related to release of Ca2+ from the dantrolene-sensitive stores. Hexachlorocyclohexane 33-40 carbonic anhydrase 2 Rattus norvegicus 80-83 7503757-9 1995 The joint administration of T3 and lindane, however, elicited a marked elevation in serum GOT and glutamate pyruvate transaminase (GPT), concomitantly with extensive liver necrosis and the presence of granulomas containing lymphocytes, Kupffer cells and polymorphonuclear leukocytes (PMN). Hexachlorocyclohexane 35-42 glutamic--pyruvic transaminase Rattus norvegicus 98-129 8824497-1 1996 Treatment of WB-F344 rat liver epithelial cells with DDT (1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane) or lindane induces a loss of gap junction plaques and a decrease in the phosphorylated gap junction protein connexin43-P2 (Cx43-P2), which is associated with the plaques. Hexachlorocyclohexane 108-115 gap junction protein, alpha 1 Rattus norvegicus 228-232 8824497-4 1996 Immunohistochemical analyses of DDT- or lindane-treated cells revealed a reduction in plasma membranous Cx43-positive gap junction plaques coincident with the appearance of Cx43-positive punctate cytoplasmic structures. Hexachlorocyclohexane 40-47 gap junction protein, alpha 1 Rattus norvegicus 104-108 8824497-4 1996 Immunohistochemical analyses of DDT- or lindane-treated cells revealed a reduction in plasma membranous Cx43-positive gap junction plaques coincident with the appearance of Cx43-positive punctate cytoplasmic structures. Hexachlorocyclohexane 40-47 gap junction protein, alpha 1 Rattus norvegicus 173-177 8824497-11 1996 These immunohistochemical and biochemical data strongly suggest that the loss of gap junction plaques and of Cx43-P2 in WB-F344 cells treated with DDT and lindane were due to endocytosis of the plaques and degradation of Cx43-P2 in lysosomes. Hexachlorocyclohexane 155-162 gap junction protein, alpha 1 Rattus norvegicus 109-113 8824497-11 1996 These immunohistochemical and biochemical data strongly suggest that the loss of gap junction plaques and of Cx43-P2 in WB-F344 cells treated with DDT and lindane were due to endocytosis of the plaques and degradation of Cx43-P2 in lysosomes. Hexachlorocyclohexane 155-162 gap junction protein, alpha 1 Rattus norvegicus 221-225 8812189-10 1996 Lindane shares the criteria of the second and third groups and seems to induce both CYP1A and CYP2B activities. Hexachlorocyclohexane 0-7 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 94-99 8949935-0 1996 Differential effects of hexachlorocyclohexane isomers on the GABA receptor subunits expressed in human embryonic kidney cell line. Hexachlorocyclohexane 24-45 GABA type A receptor-associated protein Homo sapiens 61-74 7503757-9 1995 The joint administration of T3 and lindane, however, elicited a marked elevation in serum GOT and glutamate pyruvate transaminase (GPT), concomitantly with extensive liver necrosis and the presence of granulomas containing lymphocytes, Kupffer cells and polymorphonuclear leukocytes (PMN). Hexachlorocyclohexane 35-42 glutamic--pyruvic transaminase Rattus norvegicus 131-134 7561871-4 1995 The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons. Hexachlorocyclohexane 93-120 calmodulin 2 Mus musculus 4-14 7558821-5 1995 In this article we review older and more recent data on pharmacology, pharmacokinetics and toxicology of gamma-1,2,3,4,5,6-Hexachlorcyclohexan [Lindane]. Hexachlorocyclohexane 144-151 tryptophanyl-tRNA synthetase 1 Homo sapiens 105-116 8800639-2 1995 We showed that chlordecone, nonylphenol, a polychlorobiphenol (PCB) mixture (Aroclor 1245) and lindane were able to induce ER and Vg mRNA accumulation. Hexachlorocyclohexane 95-102 estrogen receptor Oncorhynchus mykiss 123-125 8800639-2 1995 We showed that chlordecone, nonylphenol, a polychlorobiphenol (PCB) mixture (Aroclor 1245) and lindane were able to induce ER and Vg mRNA accumulation. Hexachlorocyclohexane 95-102 LOC100136735 Oncorhynchus mykiss 130-132 7530866-0 1995 Changes in gap junction permeability, gap junction number, and connexin43 expression in lindane-treated rat liver epithelial cells. Hexachlorocyclohexane 88-95 gap junction protein, alpha 1 Rattus norvegicus 63-73 7543649-0 1995 Effect of hexachlorocyclohexane isomers on calmodulin mRNA expression in the central nervous system. Hexachlorocyclohexane 10-31 calmodulin 1 Rattus norvegicus 43-53 7543649-3 1995 We have investigated the possibility of differential expression of two calmodulin genes, CaM I and CaM II, which are expressed strongly in neuronal cells in the adult rat brain, after treatment with the gamma (lindane) and the delta isomers of the hexachlorocyclohexane (HCH). Hexachlorocyclohexane 203-217 calmodulin 1 Rattus norvegicus 71-81 7543649-3 1995 We have investigated the possibility of differential expression of two calmodulin genes, CaM I and CaM II, which are expressed strongly in neuronal cells in the adult rat brain, after treatment with the gamma (lindane) and the delta isomers of the hexachlorocyclohexane (HCH). Hexachlorocyclohexane 203-217 calmodulin 1 Rattus norvegicus 89-94 7543649-3 1995 We have investigated the possibility of differential expression of two calmodulin genes, CaM I and CaM II, which are expressed strongly in neuronal cells in the adult rat brain, after treatment with the gamma (lindane) and the delta isomers of the hexachlorocyclohexane (HCH). Hexachlorocyclohexane 248-269 calmodulin 1 Rattus norvegicus 71-81 7543649-3 1995 We have investigated the possibility of differential expression of two calmodulin genes, CaM I and CaM II, which are expressed strongly in neuronal cells in the adult rat brain, after treatment with the gamma (lindane) and the delta isomers of the hexachlorocyclohexane (HCH). Hexachlorocyclohexane 248-269 calmodulin 1 Rattus norvegicus 89-94 7543649-3 1995 We have investigated the possibility of differential expression of two calmodulin genes, CaM I and CaM II, which are expressed strongly in neuronal cells in the adult rat brain, after treatment with the gamma (lindane) and the delta isomers of the hexachlorocyclohexane (HCH). Hexachlorocyclohexane 271-274 calmodulin 1 Rattus norvegicus 71-81 7543649-3 1995 We have investigated the possibility of differential expression of two calmodulin genes, CaM I and CaM II, which are expressed strongly in neuronal cells in the adult rat brain, after treatment with the gamma (lindane) and the delta isomers of the hexachlorocyclohexane (HCH). Hexachlorocyclohexane 271-274 calmodulin 1 Rattus norvegicus 89-94 7543649-6 1995 The levels of mRNA of calmodulin CaM II gene were also found to decrease after lindane administration; delta-HCH produced an increase of this transcript. Hexachlorocyclohexane 79-86 calmodulin 1 Rattus norvegicus 22-32 7534335-0 1995 Regulation of c-fos expression by convulsants and hexachlorocyclohexane isomers in primary cultures of cortical neurons. Hexachlorocyclohexane 50-71 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 14-19 7534335-4 1995 Lindane (gamma-hexachlorocyclohexane), Bay K 8644, pentylenetetrazole, and picrotoxinin produced a significant increase in c-fos immunoreactivity and in c-fos mRNA expression. Hexachlorocyclohexane 0-7 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 123-128 7534335-4 1995 Lindane (gamma-hexachlorocyclohexane), Bay K 8644, pentylenetetrazole, and picrotoxinin produced a significant increase in c-fos immunoreactivity and in c-fos mRNA expression. Hexachlorocyclohexane 0-7 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 153-158 7534335-4 1995 Lindane (gamma-hexachlorocyclohexane), Bay K 8644, pentylenetetrazole, and picrotoxinin produced a significant increase in c-fos immunoreactivity and in c-fos mRNA expression. Hexachlorocyclohexane 9-36 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 123-128 7534335-4 1995 Lindane (gamma-hexachlorocyclohexane), Bay K 8644, pentylenetetrazole, and picrotoxinin produced a significant increase in c-fos immunoreactivity and in c-fos mRNA expression. Hexachlorocyclohexane 9-36 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 153-158 7534335-8 1995 The results obtained with delta-hexachlorocyclohexane and nifedipine suggest that picrotoxinin activates c-fos expression by calcium-requiring intracellular signaling pathways that are different from those activated by Bay K 8644, pentylenetetrazole, or gamma-hexachlorocyclohexane, which, at least in part, act via L-type calcium channels. Hexachlorocyclohexane 254-281 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 105-110 7538972-0 1995 Hexachlorocyclohexane-induced changes in lipid peroxidation, superoxide dismutase and catalase activities and glutathione content in chick liver. Hexachlorocyclohexane 0-21 catalase Gallus gallus 86-94 7539369-1 1995 Acute and long-term toxicity of 3,4-dichloroaniline and lindane to zebrafish were examined in tap water and water from the Rhine River and the toxicity of the binary mixture 3,4-dichloroaniline/lindane in tap water was investigated. Hexachlorocyclohexane 56-63 transporter associated with antigen processing, subunit type c Danio rerio 94-97 7539369-5 1995 The binary mixture of 2 micrograms/liter, 3,4-dichloroaniline and 40 micrograms/liter lindane in tap water had an influence on growth on the early life stages of zebrafish. Hexachlorocyclohexane 86-93 transporter associated with antigen processing, subunit type c Danio rerio 97-100 7530866-10 1995 Nuclear run-on assays indicated that transcription of the connexin43 gene was reduced nonspecifically by lindane. Hexachlorocyclohexane 105-112 gap junction protein, alpha 1 Rattus norvegicus 58-68 7532328-5 1995 The results show significant decrease in the activities of 5"-Nucleotidase, Ca(2+)-ATPase, Na(+) + K(+)-ATPase and Mg(2+)-ATPase in the plasma membrane of testis following exposure to HCH. Hexachlorocyclohexane 184-187 5' nucleotidase, ecto Rattus norvegicus 59-74 7531829-0 1994 Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression. Hexachlorocyclohexane 79-86 calmodulin 2 Mus musculus 27-37 7535533-6 1995 Lindane in the refeeding diet blunted this overshoot of FAS and CCE activities in a dose-dependent manner. Hexachlorocyclohexane 0-7 fatty acid synthase Rattus norvegicus 56-59 7535533-6 1995 Lindane in the refeeding diet blunted this overshoot of FAS and CCE activities in a dose-dependent manner. Hexachlorocyclohexane 0-7 ATP citrate lyase Rattus norvegicus 64-67 7535533-7 1995 In contrast, activities of Me, G6PDH and PGDH responded to low dietary lindane concentrations with a substantial stimulation of the increase of activity, whereas at high lindane concentrations the overshoot was inhibited. Hexachlorocyclohexane 71-78 glucose-6-phosphate dehydrogenase Rattus norvegicus 31-36 7535533-7 1995 In contrast, activities of Me, G6PDH and PGDH responded to low dietary lindane concentrations with a substantial stimulation of the increase of activity, whereas at high lindane concentrations the overshoot was inhibited. Hexachlorocyclohexane 71-78 15-hydroxyprostaglandin dehydrogenase Rattus norvegicus 41-45 7535533-8 1995 According to their responses to lindane exposure, liver lipogenic enzymes could be grouped into 2 categories with FAS and CCE representing one and ME, G6PDH and PGDH representing the other group. Hexachlorocyclohexane 32-39 fatty acid synthase Rattus norvegicus 114-117 7535533-8 1995 According to their responses to lindane exposure, liver lipogenic enzymes could be grouped into 2 categories with FAS and CCE representing one and ME, G6PDH and PGDH representing the other group. Hexachlorocyclohexane 32-39 ATP citrate lyase Rattus norvegicus 122-125 7535533-8 1995 According to their responses to lindane exposure, liver lipogenic enzymes could be grouped into 2 categories with FAS and CCE representing one and ME, G6PDH and PGDH representing the other group. Hexachlorocyclohexane 32-39 glucose-6-phosphate dehydrogenase Rattus norvegicus 151-156 7535533-8 1995 According to their responses to lindane exposure, liver lipogenic enzymes could be grouped into 2 categories with FAS and CCE representing one and ME, G6PDH and PGDH representing the other group. Hexachlorocyclohexane 32-39 15-hydroxyprostaglandin dehydrogenase Rattus norvegicus 161-165 7523654-1 1994 Lindane (gamma-hexachlorocyclohexane) is an organochlorine pesticide that increases intracellular free calcium ([Ca++]i) in several tissues. Hexachlorocyclohexane 0-7 carbonic anhydrase 1 Rattus norvegicus 113-119 7523654-1 1994 Lindane (gamma-hexachlorocyclohexane) is an organochlorine pesticide that increases intracellular free calcium ([Ca++]i) in several tissues. Hexachlorocyclohexane 9-36 carbonic anhydrase 1 Rattus norvegicus 113-119 7534833-4 1994 An interaction with the GABA receptor-gated chloride channel was demonstrated by an inhibitory action of lindane on [35S]TBPS binding (IC50 188 +/- 51 nM) and on GABA-stimulated 36Cl- influx in the neurons. Hexachlorocyclohexane 105-112 GABA type A receptor-associated protein Homo sapiens 24-37 7531829-10 1994 In accordance with the behavioural results, W-7 antagonized also the c-fos expression induced by lindane and BayK-8644. Hexachlorocyclohexane 97-104 FBJ osteosarcoma oncogene Mus musculus 69-74 7531829-11 1994 Our results suggest that lindane as BayK-8644 may activate voltage-dependent calcium channels leading to calmodulin activation. Hexachlorocyclohexane 25-32 calmodulin 2 Mus musculus 105-115 7524197-1 1994 Lindane, gamma-1,2,3,4,5,6-hexachlorocyclohexane (gamma-HCH), has been shown to disrupt reproductive function in mammals. Hexachlorocyclohexane 0-7 crystallin, gamma E Rattus norvegicus 9-20 7524197-1 1994 Lindane, gamma-1,2,3,4,5,6-hexachlorocyclohexane (gamma-HCH), has been shown to disrupt reproductive function in mammals. Hexachlorocyclohexane 50-59 crystallin, gamma E Rattus norvegicus 9-20 7524197-3 1994 It has been suggested that gamma-HCH may block the response of estrogen-dependent tissues to estradiol via an interaction with the estrogen receptor. Hexachlorocyclohexane 27-36 estrogen receptor 1 Rattus norvegicus 131-148 7523654-6 1994 The lindane response was apparently independent of external calcium because equivalent [Ca++]i responses were observed in cells exposed to lindane in Ca(++)-containing and Ca(++)-free media and in the presence of 10 microM nifedipine, a dihydropyridine blocker of plasma membrane voltage-sensitive Ca++ channels. Hexachlorocyclohexane 4-11 carbonic anhydrase 1 Rattus norvegicus 88-94 7523654-6 1994 The lindane response was apparently independent of external calcium because equivalent [Ca++]i responses were observed in cells exposed to lindane in Ca(++)-containing and Ca(++)-free media and in the presence of 10 microM nifedipine, a dihydropyridine blocker of plasma membrane voltage-sensitive Ca++ channels. Hexachlorocyclohexane 139-146 carbonic anhydrase 1 Rattus norvegicus 88-94 7523654-8 1994 These experiments suggest that lindane increases [Ca++]i through the selective release of inositol 1,4,5-trisphosphate-sensitive Ca++ stores. Hexachlorocyclohexane 31-38 carbonic anhydrase 1 Rattus norvegicus 50-56 7523654-3 1994 The present study, therefore, investigated whether lindane exposure modulated [Ca++]i in myometrial smooth muscle cells. Hexachlorocyclohexane 51-58 carbonic anhydrase 1 Rattus norvegicus 79-85 7523654-4 1994 This study demonstrated that lindane, but not beta-hexachlorocyclohexane, increased [Ca++]i in a concentration-dependent manner in individual rat myometrial cells, as measured with the calcium-sensitive probe fura-2-AM. Hexachlorocyclohexane 29-36 carbonic anhydrase 1 Rattus norvegicus 85-91 7524595-5 1994 The effect of lindane follows a different pattern from that of bradykinin, and it is suggested to act by stimulating phospholipase A activity(ies). Hexachlorocyclohexane 14-21 phospholipase A and acyltransferase 1 Rattus norvegicus 117-132 7689801-6 1993 After IP administration of lindane, the difference in CD50 or LD50 among control, activated charcoal, or cholestyramine groups was not significantly different. Hexachlorocyclohexane 27-34 intercellular adhesion molecule 5, telencephalin Mus musculus 54-58 7694769-0 1993 Anticonvulsant activity of delta-HCH, calcium channel blockers and calmodulin antagonists in seizures induced by lindane and other convulsant drugs. Hexachlorocyclohexane 113-120 calmodulin 2 Mus musculus 67-77 7512143-7 1994 Concomitantly, liver glutathione content and the activity of glutathione peroxidase-glutathione reductase couple were augmented by lindane treatment, without any change in superoxide dismutase activity, together with a reduction in that of catalase. Hexachlorocyclohexane 131-138 catalase Rattus norvegicus 240-248 7504641-1 1993 Lindane (gamma-1,2,3,4,5,6-hexachlorocyclohexane), a widely used insecticide, may be found at low concentrations in the human diet. Hexachlorocyclohexane 0-7 tryptophanyl-tRNA synthetase 1 Homo sapiens 9-20 1280523-10 1992 These results suggest that besides the GABAA receptor complex other mechanisms related to calcium mobilization may be involved in the convulsant action of lindane. Hexachlorocyclohexane 155-162 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 39-44 7692623-1 1993 The administration of lindane (60 mg/kg) to fed rats diminished the content of hepatic glutathione (GSH) 4 h after treatment, which was recovered at 24 h. At these experimental times, the activities of glutathione peroxidase, glutathione reductase, glutathione-S-transferases and gamma-glutamyltransferase in the liver of lindane-treated rats and control animals were comparable. Hexachlorocyclohexane 22-29 glutathione-disulfide reductase Rattus norvegicus 226-247 1718548-0 1991 Lindane may enhance nocturnal pineal N-acetyltransferase activity via beta-adrenergic receptors. Hexachlorocyclohexane 0-7 N-acetyltransferase 1 Rattus norvegicus 37-56 1382176-2 1992 c-fos has been found activated after the administration of the organochlorine insecticide lindane, the Ca2+ channel agonist Bay K, and N-methyl-D-aspartate (NMDA). Hexachlorocyclohexane 90-97 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 0-5 1382176-4 1992 The effect of lindane on c-fos expression could not be blocked by prior administration of MK-801, a non-competitive antagonist of the NMDA receptor. Hexachlorocyclohexane 14-21 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 25-30 1371151-0 1992 c-fos expression as a model for studying the action of hexachlorocyclohexane isomers in the CNS. Hexachlorocyclohexane 55-76 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 0-5 1371151-2 1992 The organochlorine insecticide gamma-hexachlorocyclohexane (gamma-HCH, lindane) has been shown to induce c-fos expression in different brain areas. Hexachlorocyclohexane 31-58 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 105-110 1371151-2 1992 The organochlorine insecticide gamma-hexachlorocyclohexane (gamma-HCH, lindane) has been shown to induce c-fos expression in different brain areas. Hexachlorocyclohexane 60-69 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 105-110 1371151-2 1992 The organochlorine insecticide gamma-hexachlorocyclohexane (gamma-HCH, lindane) has been shown to induce c-fos expression in different brain areas. Hexachlorocyclohexane 71-78 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 105-110 20732086-0 1992 Effects of lindane on the accumulation of cyclic AMP, induced by vasoactive intestinal peptide, in isolated rat prostatic epithelial cells. Hexachlorocyclohexane 11-18 vasoactive intestinal peptide Rattus norvegicus 65-94 20732086-1 1992 Lindane pretreatment of isolated rat prostatic epithelial cells resulted in a time- and dose-dependent impairment of the stimulation of cyclic AMP levels by vasoactive intestinal peptide (VIP); the optimal conditions for producing this impairment were found to be 5 min of cell exposure to 0.2 mm-lindane at 25 degrees C. The inhibitory effect of the insecticide was related to a decrease in VIP efficiency since the maximal cyclic AMP response (at 100 nm VIP) was about 50% of that in control cells. Hexachlorocyclohexane 0-7 vasoactive intestinal peptide Rattus norvegicus 157-186 20732086-1 1992 Lindane pretreatment of isolated rat prostatic epithelial cells resulted in a time- and dose-dependent impairment of the stimulation of cyclic AMP levels by vasoactive intestinal peptide (VIP); the optimal conditions for producing this impairment were found to be 5 min of cell exposure to 0.2 mm-lindane at 25 degrees C. The inhibitory effect of the insecticide was related to a decrease in VIP efficiency since the maximal cyclic AMP response (at 100 nm VIP) was about 50% of that in control cells. Hexachlorocyclohexane 0-7 vasoactive intestinal peptide Rattus norvegicus 188-191 20732086-1 1992 Lindane pretreatment of isolated rat prostatic epithelial cells resulted in a time- and dose-dependent impairment of the stimulation of cyclic AMP levels by vasoactive intestinal peptide (VIP); the optimal conditions for producing this impairment were found to be 5 min of cell exposure to 0.2 mm-lindane at 25 degrees C. The inhibitory effect of the insecticide was related to a decrease in VIP efficiency since the maximal cyclic AMP response (at 100 nm VIP) was about 50% of that in control cells. Hexachlorocyclohexane 0-7 vasoactive intestinal peptide Rattus norvegicus 392-395 20732086-1 1992 Lindane pretreatment of isolated rat prostatic epithelial cells resulted in a time- and dose-dependent impairment of the stimulation of cyclic AMP levels by vasoactive intestinal peptide (VIP); the optimal conditions for producing this impairment were found to be 5 min of cell exposure to 0.2 mm-lindane at 25 degrees C. The inhibitory effect of the insecticide was related to a decrease in VIP efficiency since the maximal cyclic AMP response (at 100 nm VIP) was about 50% of that in control cells. Hexachlorocyclohexane 0-7 vasoactive intestinal peptide Rattus norvegicus 392-395 20732086-1 1992 Lindane pretreatment of isolated rat prostatic epithelial cells resulted in a time- and dose-dependent impairment of the stimulation of cyclic AMP levels by vasoactive intestinal peptide (VIP); the optimal conditions for producing this impairment were found to be 5 min of cell exposure to 0.2 mm-lindane at 25 degrees C. The inhibitory effect of the insecticide was related to a decrease in VIP efficiency since the maximal cyclic AMP response (at 100 nm VIP) was about 50% of that in control cells. Hexachlorocyclohexane 296-304 vasoactive intestinal peptide Rattus norvegicus 188-191 20732086-2 1992 VIP potency was unaffected since the half-maximal cyclic AMP response was elicited at about 3 nm VIP in both the control and lindane-pretreated cells. Hexachlorocyclohexane 125-132 vasoactive intestinal peptide Rattus norvegicus 97-100 1380685-0 1992 Effect of gamma-hexachlorocyclohexane and its isomers on proto-oncogene c-fos expression in brain. Hexachlorocyclohexane 10-37 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 57-77 1380685-2 1992 The organochlorine insecticide gamma-hexachlorocyclohexane (lindane) has been shown to induce c-fos expression in a dose dependent manner. Hexachlorocyclohexane 31-58 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 94-99 1380685-2 1992 The organochlorine insecticide gamma-hexachlorocyclohexane (lindane) has been shown to induce c-fos expression in a dose dependent manner. Hexachlorocyclohexane 60-67 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 94-99 1380685-3 1992 30 mg/kg of lindane increased c-fos expression in cortical and hippocampal areas. Hexachlorocyclohexane 12-19 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 30-35 1718548-1 1991 Lindane, a chlorinated hydrocarbon pesticide, was previously shown to enhance the nighttime rise in pineal N-acetyltransferase (NAT) activity and melatonin as well as serum melatonin levels. Hexachlorocyclohexane 0-7 N-acetyltransferase 1 Rattus norvegicus 107-126 1718548-1 1991 Lindane, a chlorinated hydrocarbon pesticide, was previously shown to enhance the nighttime rise in pineal N-acetyltransferase (NAT) activity and melatonin as well as serum melatonin levels. Hexachlorocyclohexane 0-7 N-acetyltransferase 1 Rattus norvegicus 128-131 1718548-5 1991 The augmentation of NAT activity by lindane also caused significant reductions in pineal serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA); again, both these responses were blocked by propranolol treatment. Hexachlorocyclohexane 36-43 N-acetyltransferase 1 Rattus norvegicus 20-23 1715830-4 1991 The induction of alpha 2u-nephropathy in F344 male rats with lindane was used as a positive control and this response was contrasted to male NBR and female F344 rats treated with lindane. Hexachlorocyclohexane 61-68 alpha2u globulin Rattus norvegicus 17-25 1715830-10 1991 It is thus concluded that the presence of alpha 2u is causal to the development of renal disease in rats exposed to TMP, DCB, IP, UG, d-L, and lindane. Hexachlorocyclohexane 143-150 alpha2u globulin Rattus norvegicus 42-50 1708174-1 1991 Rats treated with diets containing 20 ppm of alpha- or gamma-hexachlorocyclohexane (HCH) for 15 or 30 days showed increased levels of liver cytochrome P-450 followed by increased production of both thiobarbituric acid reactants by liver homogenates and microsomes and superoxide anion production by liver microsomes. Hexachlorocyclohexane 84-87 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 140-156 1699300-0 1990 Lindane induces nephropathy and renal accumulation of alpha 2u-globulin in male but not in female Fischer 344 rats or male NBR rats. Hexachlorocyclohexane 0-7 alpha2u globulin Rattus norvegicus 54-71 1701514-2 1990 Furthermore, the immunohistochemical study of brains by means of a MBP (myelin basic protein) specific antibody reveals myelin deficits in some brain regions after lindane treatment. Hexachlorocyclohexane 164-171 myelin basic protein Rattus norvegicus 67-70 1701514-2 1990 Furthermore, the immunohistochemical study of brains by means of a MBP (myelin basic protein) specific antibody reveals myelin deficits in some brain regions after lindane treatment. Hexachlorocyclohexane 164-171 myelin basic protein Rattus norvegicus 72-92 1710164-1 1991 An increase of proto-oncogene c-fos expression in cerebral cortex of rats treated with subconvulsant doses of the pesticide organochlorine lindane (gamma-hexachlorocyclohexane) has been detected using Northern blots. Hexachlorocyclohexane 148-175 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 30-35 1710164-5 1991 High levels of ODC mRNA and increased enzyme activity in cortex were found in rats following lindane treatment. Hexachlorocyclohexane 93-100 ornithine decarboxylase 1 Rattus norvegicus 15-18 1714421-1 1991 Repeated dermal application of hexachlorocyclohexane (HCH; 100 mg/kg/day) or methyl parathion (2 mg/kg/day) individually or in combination for 7, 15 and 30 days produced pathomorphological changes in skin, liver, kidney and brain of female rats along with significant enzymatic alterations in the activity of transaminase, alkaline phosphatase lactic dehydrogenase and acetylcholinesterase. Hexachlorocyclohexane 31-52 acetylcholinesterase Rattus norvegicus 369-389 35204751-3 2022 To document the role of the ATM-dependent DSB repair and signaling after pesticide exposure, we applied six current pesticides of domestic and environmental interest (lindane, atrazine, glyphosate, permethrin, pentachlorophenol and thiabendazole) to human skin fibroblast and brain cells. Hexachlorocyclohexane 167-174 ATM serine/threonine kinase Homo sapiens 28-31 1697652-3 1990 Nocturnal NAT activity was increased after lindane administration; likewise, lindane augmented pineal and serum melatonin levels at 2300h. Hexachlorocyclohexane 43-50 N-acetyltransferase 1 Rattus norvegicus 10-13 1699849-3 1990 In addition, the interaction of lindane with the liver tissue results in the induction of the microsomal cytochrome P-450 system, together with enhanced rates of superoxide radical generation and a significant increase in indicators of lipid peroxidation. Hexachlorocyclohexane 32-39 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 105-121 34929275-7 2022 Moreover, lindane exposure down-regulated the expression of dat-1, dop-1, glr-1 and mod-1genes, while up-regulated unc-30 gene in P0 generation, which recovered to normal levels in F4 generation. Hexachlorocyclohexane 10-17 Sodium-dependent dopamine transporter Caenorhabditis elegans 60-65 34929275-7 2022 Moreover, lindane exposure down-regulated the expression of dat-1, dop-1, glr-1 and mod-1genes, while up-regulated unc-30 gene in P0 generation, which recovered to normal levels in F4 generation. Hexachlorocyclohexane 10-17 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 67-72 34929275-7 2022 Moreover, lindane exposure down-regulated the expression of dat-1, dop-1, glr-1 and mod-1genes, while up-regulated unc-30 gene in P0 generation, which recovered to normal levels in F4 generation. Hexachlorocyclohexane 10-17 Glutamate receptor 1 Caenorhabditis elegans 74-79 34929275-7 2022 Moreover, lindane exposure down-regulated the expression of dat-1, dop-1, glr-1 and mod-1genes, while up-regulated unc-30 gene in P0 generation, which recovered to normal levels in F4 generation. Hexachlorocyclohexane 10-17 Uncharacterized protein Caenorhabditis elegans 84-89 34929275-7 2022 Moreover, lindane exposure down-regulated the expression of dat-1, dop-1, glr-1 and mod-1genes, while up-regulated unc-30 gene in P0 generation, which recovered to normal levels in F4 generation. Hexachlorocyclohexane 10-17 Homeobox domain-containing protein;Homeobox protein unc-30 Caenorhabditis elegans 115-121 34929275-8 2022 Interestingly, eat-4 continued to be regulated from inhibition to stimulation in P0-F4 generations, suggesting that glutamatergic transmission may more contribute to the neurotoxicity of lindane over generations. Hexachlorocyclohexane 187-194 MFS domain-containing protein;putative vesicular glutamate transporter eat-4 Caenorhabditis elegans 15-20 34072471-2 2021 Among all, growing interest has been focused on beta-hexachlorocyclohexane (beta-HCH), virtually the most hazardous and, at the same time, the most poorly investigated member of the hexachlorocyclohexane family. Hexachlorocyclohexane 182-203 nuclear receptor subfamily 0 group B member 1 Homo sapiens 76-84 35609655-6 2022 Oxidative stress assay showed that ROS and apoptosis were highest in the fish exposed to beta-2 and delta-2 isomers of HCH in comparison to the untreated one. Hexachlorocyclohexane 119-122 zgc:103599 Danio rerio 89-95 2479123-1 1989 The effects of the beta-isomer of hexachlorocyclohexane (beta-HCH) on the induction of the cytosolic progesterone receptor (PgRc), on the redistribution of the estrogen receptor (ER), and its affinity for ER were investigated in the estrogen-sensitive human mammary tumor cell line MCF-7. Hexachlorocyclohexane 34-55 progesterone receptor Homo sapiens 101-122 2482969-1 1989 Effects of hexachlorocyclohexane (Technical HCH) on the contractile responses of rat isolated Vas deferens to norepinephrine (NE) were investigated by varying the Ca++ and Mg++ concentrations of the incubation medium. Hexachlorocyclohexane 44-47 arginine vasopressin Rattus norvegicus 94-97 2479123-1 1989 The effects of the beta-isomer of hexachlorocyclohexane (beta-HCH) on the induction of the cytosolic progesterone receptor (PgRc), on the redistribution of the estrogen receptor (ER), and its affinity for ER were investigated in the estrogen-sensitive human mammary tumor cell line MCF-7. Hexachlorocyclohexane 34-55 progesterone receptor Homo sapiens 124-128 2483843-0 1989 Lindane mediated induction of cytochrome P-450 mRNA in rat liver: studies with a nonradioactive cDNA probe. Hexachlorocyclohexane 0-7 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 30-46 2483843-1 1989 Effect of lindane on the induction of cytochrome P-450 mRNA in rat liver was studied using a biotinylated cDNA probe. Hexachlorocyclohexane 10-17 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 38-54 2471237-0 1989 Histological and pharmacological changes in vas deferens of rats exposed to hexachlorocyclohexane. Hexachlorocyclohexane 76-97 arginine vasopressin Rattus norvegicus 44-47 2481647-5 1989 Hepatic glucose-6-phosphatase was lowered by HCH while aldolase activity was increased. Hexachlorocyclohexane 45-48 glucose-6-phosphatase, catalytic Mus musculus 8-29 2467674-1 1989 Isolated rat enterocytes exposed to the insecticide lindane (the gamma-isomer of hexachlorocyclohexane, HCCH) showed an important decrease in the efficiency of the neuropeptide vasoactive intestinal peptide (VIP) upon the stimulation of cyclic AMP accumulation. Hexachlorocyclohexane 52-59 vasoactive intestinal peptide Rattus norvegicus 208-211 2467674-1 1989 Isolated rat enterocytes exposed to the insecticide lindane (the gamma-isomer of hexachlorocyclohexane, HCCH) showed an important decrease in the efficiency of the neuropeptide vasoactive intestinal peptide (VIP) upon the stimulation of cyclic AMP accumulation. Hexachlorocyclohexane 81-102 vasoactive intestinal peptide Rattus norvegicus 208-211 2460971-0 1988 The potency of gamma-1,2,3,4,5,6-hexachlorocyclohexane (lindane). Hexachlorocyclohexane 56-63 tryptophanyl-tRNA synthetase 1 Homo sapiens 15-26 2460971-1 1988 The potency of gamma-1,2,3,4,5,6-hexachlorocyclohexane (lindane) as a convulsant was examined in rats by infusion into a tail vein of the unrestrained animal using a lipid emulsion as vehicle and a dose rate of 200 micrograms/min. Hexachlorocyclohexane 56-63 crystallin, gamma E Rattus norvegicus 15-26 2469257-4 1988 Lindane (60 mg/kg) administered orally to rats increased liver cytochrome P-450 content and superoxide radical (O2-.) Hexachlorocyclohexane 0-7 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 63-79 2469257-12 1988 Lindane administration results in time-dependent oxidative stress in liver which involves an early component (4-6 h) related to the reductive metabolism of lindane, and a late component (24 h) associated with the induction of cytochrome P-450; the biochemical changes correlated with the observed morphological lesions. Hexachlorocyclohexane 0-7 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 226-242 2461408-3 1988 Treatment of rats with beta- and gamma-isomers of HCH increased the hepatic glucose-6-phosphate dehydrogenase and aldolase activities suggesting a higher rate of glucose oxidation. Hexachlorocyclohexane 50-53 glucose-6-phosphate dehydrogenase Rattus norvegicus 76-109 2471492-0 1988 Relative induction of molecular forms of cytochrome P-450 in gamma-hexachlorocyclohexane exposed rat liver microsomes. Hexachlorocyclohexane 61-88 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 41-57 2452708-0 1988 Modes of action and combination effects of polychlorinated biphenyls and gamma-hexachlorocyclohexane on the regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. Hexachlorocyclohexane 73-100 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 132-179 2471492-1 1988 The effect of gamma-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied. Hexachlorocyclohexane 14-41 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 144-160 2471492-1 1988 The effect of gamma-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied. Hexachlorocyclohexane 43-46 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 144-160 2471492-3 1988 It was observed that HCH is a "mixed-type" inducer and mediates induction of cytochrome P-450 b/e forms by several fold and of cytochrome P-450 c and d forms by nearly three fold. Hexachlorocyclohexane 21-24 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 77-95 2471492-3 1988 It was observed that HCH is a "mixed-type" inducer and mediates induction of cytochrome P-450 b/e forms by several fold and of cytochrome P-450 c and d forms by nearly three fold. Hexachlorocyclohexane 21-24 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 127-145 2443783-0 1987 Opposite effects of different hexachlorocyclohexane (lindane) isomers on cerebellar cyclic GMP: relation of cyclic GMP accumulation to seizure activity. Hexachlorocyclohexane 53-60 5'-nucleotidase, cytosolic II Mus musculus 91-94 2467167-0 1988 [Comparative studies of radioactivity of the blood and urine of rats after intravenous, intraperitoneal and intragastric administration of C-14-labeled lindane]. Hexachlorocyclohexane 152-159 anti-Mullerian hormone receptor type 2 Rattus norvegicus 139-143 2469048-2 1988 Exposure to lindane (gamma HCH) produced a dose-dependent increase in [Ca++]i, significant increases being observed with exposures from 10-400 microM. Hexachlorocyclohexane 12-19 carbonic anhydrase 1 Homo sapiens 71-77 2469048-2 1988 Exposure to lindane (gamma HCH) produced a dose-dependent increase in [Ca++]i, significant increases being observed with exposures from 10-400 microM. Hexachlorocyclohexane 21-30 carbonic anhydrase 1 Homo sapiens 71-77 2469048-7 1988 The effects of HCH isomers on [Ca++]i in neurohybridoma cells are similar to those reported for the isomers using rat brain synaptosomes. Hexachlorocyclohexane 15-18 carbonic anhydrase 1 Rattus norvegicus 31-37 2469048-8 1988 The ability of lindane to increase [Ca++]i may explain the previously reported ability of lindane to increase spontaneous and evoked (under low quantal release conditions) release of transmitter from frog neuromuscular junction. Hexachlorocyclohexane 15-22 carbonic anhydrase 1 Homo sapiens 36-42 2469048-8 1988 The ability of lindane to increase [Ca++]i may explain the previously reported ability of lindane to increase spontaneous and evoked (under low quantal release conditions) release of transmitter from frog neuromuscular junction. Hexachlorocyclohexane 90-97 carbonic anhydrase 1 Homo sapiens 36-42 2443783-4 1987 Gamma-HCH increased cyclic GMP while alpha and delta-HCH decreased it. Hexachlorocyclohexane 0-9 5'-nucleotidase, cytosolic II Mus musculus 27-30 2443783-8 1987 It is concluded that the different HCH isomers can have different effects on cerebellar cyclic GMP accumulation and that these effects may be mediated through actions at the GABA-A receptor linked chloride channel. Hexachlorocyclohexane 35-38 5'-nucleotidase, cytosolic II Mus musculus 95-98 3569844-3 1987 With the exception of lindane, all the organochlorine pesticides and PB induced testosterone 16 alpha- and 16 beta-hydroxylases; in contrast lindane induced testosterone 6 alpha-, 7 alpha- and 6 beta-hydroxylases and PB also induced testosterone 15 beta-hydroxylase and androstenedione formation. Hexachlorocyclohexane 141-148 cytochrome P450, family 2, subfamily c, polypeptide 12 Rattus norvegicus 246-253 2423606-7 1986 When neutrophils or neutrophil cytoplasts exposed to gamma-hexachlorocyclohexane were centrifuged and resuspended in stimulus-free medium, O-2 generation ceased entirely but could be reinitiated by addition of the same stimulus. Hexachlorocyclohexane 53-80 immunoglobulin kappa variable 1D-39 Homo sapiens 139-142 2425856-1 1986 The induction of the phenobarbital form of cytochrome P-450 by xenobiotics (phenobarbital, PB, hexachlorobenzene, HCB; hexachlorocyclohexane. Hexachlorocyclohexane 119-140 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-59 2429406-2 1986 doses of lindane (20, 40, 60 and 80 mg/kg) to rats produced a progressive increase in the liver microsomal content of cytochrome P-450 and in the rate of superoxide anion generation, as measured by adrenochrome formation. Hexachlorocyclohexane 9-16 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 118-134 2425214-0 1986 [Studies of radioactivity of the blood and urine of rats after intravenous administration of the C-14-labeled gamma isomer of hexachlorocyclohexane]. Hexachlorocyclohexane 126-147 anti-Mullerian hormone receptor type 2 Rattus norvegicus 97-101 2579070-0 1985 Inhibition of phosphatidylinositol synthase and other membrane-associated enzymes by stereoisomers of hexachlorocyclohexane. Hexachlorocyclohexane 102-123 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) Mus musculus 14-43 2578811-0 1985 Interactions of hexachlorocyclohexanes with the (Ca2+ + Mg2+)-ATPase from sarcoplasmic reticulum. Hexachlorocyclohexane 16-38 dynein axonemal heavy chain 8 Homo sapiens 62-68 2408303-2 1985 The effect of acute intoxication by lindane on the AChE activity in blood plasma and in crude synaptosomal fractions from six CNS areas of rats has been studied. Hexachlorocyclohexane 36-43 acetylcholinesterase Rattus norvegicus 51-55 2408303-5 1985 In the animals intoxicated by lindane a general increase in the AChE activity both in plasma and in the CNS areas studied has been observed. Hexachlorocyclohexane 30-37 acetylcholinesterase Rattus norvegicus 64-68 2408303-6 1985 The combination of sodium pentobarbital and lindane produced a decrease in the AChE activity in all the studied areas with the single exception of the spinal cord. Hexachlorocyclohexane 44-51 acetylcholinesterase Rattus norvegicus 79-83 2578811-1 1985 Hexachlorocyclohexanes have been shown to inhibit the (Ca2+ + Mg2+)-ATPase of muscle sarcoplasmic reticulum reconstituted into bilayers of dioleoylphosphatidylcholine. Hexachlorocyclohexane 0-22 dynein axonemal heavy chain 8 Homo sapiens 68-74 2578811-2 1985 However, for the ATPase reconstituted into bilayers of dimyristoleoylphosphatidylcholine, a pattern of activation at low concentration followed by inhibition at higher concentration is seen for hexachlorocyclohexanes and alkanes such as decane and hexadecane. Hexachlorocyclohexane 194-216 dynein axonemal heavy chain 8 Homo sapiens 17-23 2578811-3 1985 The ATPase in sarcoplasmic reticulum vesicles is also inhibited by the hexachlorocyclohexanes. Hexachlorocyclohexane 71-93 dynein axonemal heavy chain 8 Homo sapiens 4-10 2578811-6 1985 The hexachlorocyclohexanes quench the tryptophan fluorescence of the ATPase, and the quenching can be used to obtain partition coefficients into the membrane system. Hexachlorocyclohexane 4-26 dynein axonemal heavy chain 8 Homo sapiens 69-75 6178376-0 1982 Distribution of isomers of BHC and related histopathology of liver in hexachlorocyclohexane (technical grade BHC) fed mice. Hexachlorocyclohexane 70-91 PHD finger protein 21A Mus musculus 109-112 6206866-0 1984 Induction of gamma-glutamyl transpeptidase by hexachlorocyclohexane. Hexachlorocyclohexane 46-67 gamma-glutamyltransferase 1 Rattus norvegicus 13-42 6206866-1 1984 Hexachlorocyclohexane (BHC) induced gamma-Glutamyl transpeptidase in rat liver. Hexachlorocyclohexane 0-21 gamma-glutamyltransferase 1 Rattus norvegicus 36-65 6190702-3 1983 Striking is the increased concentration of DDT and of alpha and beta-isomeres of benzenehexachloride (BHC) in the milk of women originating from southern Europe. Hexachlorocyclohexane 81-100 D-dopachrome tautomerase Homo sapiens 43-59 6190702-3 1983 Striking is the increased concentration of DDT and of alpha and beta-isomeres of benzenehexachloride (BHC) in the milk of women originating from southern Europe. Hexachlorocyclohexane 102-105 D-dopachrome tautomerase Homo sapiens 43-59 6180316-1 1982 Male Swiss mice, 6-8 weeks old, were given a diet containing technical-grade hexachlorocyclohexane (BHC) at 500 ppm continuously for 4, 6 and 8 months. Hexachlorocyclohexane 77-98 PHD finger protein 21A Mus musculus 100-103 2578765-6 1985 These results indicate that lindane interacts readily with heme and heme proteins, including cytochrome P-450, in the absence of oxygen to undergo multiple chloride eliminations forming chlorobenzene and benzene as end products. Hexachlorocyclohexane 28-35 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 93-109 6617607-3 1983 Lindane ingestion led to a twofold increase in IgG2b antibody titer to SRBC (P less than 0.05) and carbaryl significantly increased both IgG1 and IgG2b titers. Hexachlorocyclohexane 0-7 immunoglobulin heavy constant gamma 2B Mus musculus 47-52 6183953-4 1982 Stimulation of 5"-nucleotidase activity in liver plasma membrane was observed under lindane intoxication. Hexachlorocyclohexane 84-91 5' nucleotidase, ecto Rattus norvegicus 15-30 6174209-0 1982 Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver. Hexachlorocyclohexane 79-86 gamma-glutamyltransferase 1 Rattus norvegicus 33-39 6174209-1 1982 The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats to enhance the incidence of gamma-glutamyltranspeptidase (GGTase)-positive foci was determined. Hexachlorocyclohexane 37-44 gamma-glutamyltransferase 1 Rattus norvegicus 118-146 6174209-1 1982 The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats to enhance the incidence of gamma-glutamyltranspeptidase (GGTase)-positive foci was determined. Hexachlorocyclohexane 37-44 gamma-glutamyltransferase 1 Rattus norvegicus 148-154 6174432-0 1981 Distribution of 5"-nucleotidase during hepatocarcinogenesis induced by hexachlorocyclohexane in Swiss mice. Hexachlorocyclohexane 71-92 5' nucleotidase, ecto Mus musculus 16-31 6163230-0 1980 Different levels of changes induced by the insecticide lindane in cultured C-6 glioma cells. Hexachlorocyclohexane 55-62 complement C6 Rattus norvegicus 75-78 6171509-0 1981 Histochemical changes in ATPase distribution during hexachlorocyclohexane induced hepatocarcinogenesis in inbred Swiss mice. Hexachlorocyclohexane 52-73 dynein, axonemal, heavy chain 8 Mus musculus 25-31 6176340-0 1982 Effects of lindane treatment on drug metabolizing enzymes and liver weight of CF1 mice in which it evoked hepatomas and in non-susceptible rodents. Hexachlorocyclohexane 11-18 Cardiac cell morphology QTL 1 Rattus norvegicus 78-81 6176340-1 1982 In CF1 mice lindane treatment led to a significant increase in liver tumor incidence whilst in Osborne-Mendel rats it was not carcinogenic. Hexachlorocyclohexane 12-19 Cardiac cell morphology QTL 1 Rattus norvegicus 3-6 6176340-7 1982 However, in the susceptible CF1 strain lindane led to a large increase of the absolute and relative liver weight in both sexes, whilst a smaller increase was observed in Osborne-Mendel rats. Hexachlorocyclohexane 39-46 Cardiac cell morphology QTL 1 Rattus norvegicus 28-31 6176340-9 1982 However, after treatment with the highest dose of lindane a 5-6-fold induction of this enzyme activity was observed in female CF1 mice, which then together with the male CF1 mice had a higher glutathione-S-transferase activity than untreated and treated B6C3F1 mice and Osborne-Mendel rats. Hexachlorocyclohexane 50-57 Cardiac cell morphology QTL 1 Rattus norvegicus 126-129 6176340-9 1982 However, after treatment with the highest dose of lindane a 5-6-fold induction of this enzyme activity was observed in female CF1 mice, which then together with the male CF1 mice had a higher glutathione-S-transferase activity than untreated and treated B6C3F1 mice and Osborne-Mendel rats. Hexachlorocyclohexane 50-57 Cardiac cell morphology QTL 1 Rattus norvegicus 170-173 6176340-13 1982 The most striking difference observed in this study was the fact that together with the larger increase in absolute and relative liver weight, untreated and treated CF1 mice showed higher monooxygenase activity and, after treatment with lindane, lower epoxide hydrolase activity than rats. Hexachlorocyclohexane 237-244 Cardiac cell morphology QTL 1 Rattus norvegicus 165-168 14090288-0 1963 [USE OF A HEXACHLORANE NBK (G-17) DEVICE IN CONTROLLING TICK-BORNE ENCEPHALITIS CARRIERS]. Hexachlorocyclohexane 10-22 BCL2 interacting killer Homo sapiens 23-26 68890-1 1976 Experiments conducted on albino rats poisoned with different doses of hexachlorocyclohexane (HCCH) demonstrated that large doses of this compound (1/3 DL50) following their single introduction were capable of inhibiting the secretion of the amylase, lipase, and proteases of the pancreas. Hexachlorocyclohexane 70-91 lipase G, endothelial type Rattus norvegicus 250-256 68890-1 1976 Experiments conducted on albino rats poisoned with different doses of hexachlorocyclohexane (HCCH) demonstrated that large doses of this compound (1/3 DL50) following their single introduction were capable of inhibiting the secretion of the amylase, lipase, and proteases of the pancreas. Hexachlorocyclohexane 93-97 lipase G, endothelial type Rattus norvegicus 250-256 54153-6 1975 Lindane degradation products separated and identified by TLC included gamma-2,3,4,5,6-pentachloro-1-cyclohexene (gamma-PCCH), gamma-3,4,5,6,-tetrachloro-1-cyclohexene (gamma-TCCH), gamma-3,4,5,6-tetrachloro-1-cyclohexene (gamma-TCCH), and pentachlorobenzene (PCB). Hexachlorocyclohexane 0-7 tryptophanyl-tRNA synthetase 1 Homo sapiens 70-77 83128-3 1978 After oral administration of pesticides Parathion-methyl, Carbaryl, Lindane and their combinations were investigated the activities of enzyme SGOT, SGPT, Alkaline Phosphatase and Cholinesterase. Hexachlorocyclohexane 68-75 butyrylcholinesterase Rattus norvegicus 179-193 83128-6 1978 The activity of cholinesterase is significantly lower in the combinations of Parathion-methyl/Lindane, Lindane/Carbaryl and Carbaryl/Parathion-methyl. Hexachlorocyclohexane 94-101 butyrylcholinesterase Rattus norvegicus 16-30 83128-6 1978 The activity of cholinesterase is significantly lower in the combinations of Parathion-methyl/Lindane, Lindane/Carbaryl and Carbaryl/Parathion-methyl. Hexachlorocyclohexane 103-110 butyrylcholinesterase Rattus norvegicus 16-30 33606055-2 2021 The test results showed that four HCH isomers (alpha-, beta-, gamma-, delta-HCH) were ubiquitous with HCHs concentrations ranging from 4.80 to 41.9 pg/m3 and a mean value of 17.7 pg/m3. Hexachlorocyclohexane 34-37 nuclear receptor subfamily 0 group B member 1 Homo sapiens 47-79 33888778-2 2021 Alkaline treatment of an HCH mixture in a dehydrochlorination reaction is hampered by the low reactivity of the beta-HCH isomer (HCl elimination unavoidably occurring through syn H-C-C-Cl arrangements). Hexachlorocyclohexane 25-28 synemin Homo sapiens 175-178 33606055-2 2021 The test results showed that four HCH isomers (alpha-, beta-, gamma-, delta-HCH) were ubiquitous with HCHs concentrations ranging from 4.80 to 41.9 pg/m3 and a mean value of 17.7 pg/m3. Hexachlorocyclohexane 103-107 nuclear receptor subfamily 0 group B member 1 Homo sapiens 47-79 32244031-0 2020 Transcriptional response of zebrafish larvae exposed to lindane reveals two detoxification genes of ABC transporter family (abcg5 and abcg8). Hexachlorocyclohexane 56-63 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 124-129 33463707-13 2021 Frequency of use of hexachlorocyclohexane had a positive and significant correlation with eGFR (r=0.111, p=0.045). Hexachlorocyclohexane 20-41 epidermal growth factor receptor Homo sapiens 90-94 32739526-4 2020 The selected GJIC-inhibiting EDCs (methoxychlor, triclosan, triclocarban, lindane, DDT) caused the immediate GJIC disruption by the relocation of gap junctional protein connexin 43 (Cx43) from the plasma membrane and the alternation of Cx43 phosphorylation pattern (Ser368, Ser279, Ser282) of its full-length and two N-truncated isoforms. Hexachlorocyclohexane 74-81 gap junction protein, alpha 1 Mus musculus 169-180 32739526-4 2020 The selected GJIC-inhibiting EDCs (methoxychlor, triclosan, triclocarban, lindane, DDT) caused the immediate GJIC disruption by the relocation of gap junctional protein connexin 43 (Cx43) from the plasma membrane and the alternation of Cx43 phosphorylation pattern (Ser368, Ser279, Ser282) of its full-length and two N-truncated isoforms. Hexachlorocyclohexane 74-81 gap junction protein, alpha 1 Mus musculus 182-186 32739526-4 2020 The selected GJIC-inhibiting EDCs (methoxychlor, triclosan, triclocarban, lindane, DDT) caused the immediate GJIC disruption by the relocation of gap junctional protein connexin 43 (Cx43) from the plasma membrane and the alternation of Cx43 phosphorylation pattern (Ser368, Ser279, Ser282) of its full-length and two N-truncated isoforms. Hexachlorocyclohexane 74-81 gap junction protein, alpha 1 Mus musculus 236-240 32416425-5 2020 Lindane exposure also significantly influenced the expression of genes related to intestinal development (e.g., mtm-6 and opt-2). Hexachlorocyclohexane 0-7 Myotubularin-related protein 6;Phosphatidylinositol-3-phosphate phosphatase Caenorhabditis elegans 112-117 32416425-6 2020 Moreover, reactive oxygen species production, lipofuscin accumulation, and expression of oxidation resistance genes (e.g., sod-5 and isp-1) were significantly increased in C. elegans exposed to 10-100 ng/L of lindane, which indicated that lindane exposure induced oxidative stress. Hexachlorocyclohexane 209-216 Superoxide dismutase [Cu-Zn] Caenorhabditis elegans 123-128 32416425-6 2020 Moreover, reactive oxygen species production, lipofuscin accumulation, and expression of oxidation resistance genes (e.g., sod-5 and isp-1) were significantly increased in C. elegans exposed to 10-100 ng/L of lindane, which indicated that lindane exposure induced oxidative stress. Hexachlorocyclohexane 209-216 Cytochrome b-c1 complex subunit Rieske, mitochondrial Caenorhabditis elegans 133-138 32416425-8 2020 Therefore, the adverse effects of lindane may have been induced by intestinal damage and oxidative stress, and mtm-6, opt-2, sod-5, isp-1, and mev-1 might play important roles in the toxicity of lindane. Hexachlorocyclohexane 195-202 Myotubularin-related protein 6;Phosphatidylinositol-3-phosphate phosphatase Caenorhabditis elegans 111-116 33218777-7 2021 Moreover, chronic exposure to 100 ng/L lindane significantly influenced the expression of genes related to oxidative stress and cell apoptosis (e.g., isp-1, sod-3, ced-3, and cep-1 genes). Hexachlorocyclohexane 39-46 Cytochrome b-c1 complex subunit Rieske, mitochondrial Caenorhabditis elegans 150-155 33218777-7 2021 Moreover, chronic exposure to 100 ng/L lindane significantly influenced the expression of genes related to oxidative stress and cell apoptosis (e.g., isp-1, sod-3, ced-3, and cep-1 genes). Hexachlorocyclohexane 39-46 Superoxide dismutase [Mn] 2, mitochondrial Caenorhabditis elegans 157-162 33218777-7 2021 Moreover, chronic exposure to 100 ng/L lindane significantly influenced the expression of genes related to oxidative stress and cell apoptosis (e.g., isp-1, sod-3, ced-3, and cep-1 genes). Hexachlorocyclohexane 39-46 Cell death protein 3 subunit p17 Caenorhabditis elegans 164-169 33218777-7 2021 Moreover, chronic exposure to 100 ng/L lindane significantly influenced the expression of genes related to oxidative stress and cell apoptosis (e.g., isp-1, sod-3, ced-3, and cep-1 genes). Hexachlorocyclohexane 39-46 Transcription factor cep-1 Caenorhabditis elegans 175-180 32244031-0 2020 Transcriptional response of zebrafish larvae exposed to lindane reveals two detoxification genes of ABC transporter family (abcg5 and abcg8). Hexachlorocyclohexane 56-63 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 134-139 32244031-5 2020 In addition, we characterized two sensitive and novel lindane-induced ABCG (ATP binding cassette G subfamily) transporter genes- abcg5 and abcg8. Hexachlorocyclohexane 54-61 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 129-134 32244031-5 2020 In addition, we characterized two sensitive and novel lindane-induced ABCG (ATP binding cassette G subfamily) transporter genes- abcg5 and abcg8. Hexachlorocyclohexane 54-61 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 139-144 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 13-20 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 66-71 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 13-20 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 76-81 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 13-20 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 221-226 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 13-20 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 231-236 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 111-116 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 121-126 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 221-226 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 231-236 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 111-116 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 121-126 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 5 Danio rerio 221-226 32244031-9 2020 In addition, lindane can induce the transcriptional expression of abcg5 and abcg8 genes, and overexpression of Abcg5 and Abcg8 significantly reduced the toxicity of lindane to zebrafish larvae, which means that zebrafish Abcg5 and Abcg8 are potential efflux transporters of lindane. Hexachlorocyclohexane 165-172 ATP-binding cassette, sub-family G (WHITE), member 8 Danio rerio 231-236 32292398-6 2020 A variety of enzymes participate in lindane degradation pathways, including dehydrochlorinase (LinA), dehalogenase (LinB), dehydrogenase (LinC), and reductive dechlorinase (LinD). Hexachlorocyclohexane 36-43 TNFAIP3 interacting protein 3 Homo sapiens 173-177 31969154-1 2020 BACKGROUND: Hexachlorocyclohexane is a synthetic chemical with several isomers, including beta-Hexachlorocyclohexane (beta-HCH). Hexachlorocyclohexane 12-33 nuclear receptor subfamily 0 group B member 1 Homo sapiens 118-126 30248393-5 2019 The extent of activation of RSKs and HSP25 as measured by western blot from the extent of phosphorylation of IkappaBalpha, p38 MAPK, JNK & HSP25 in lindane-exposed myotubes was higher. Hexachlorocyclohexane 152-159 heat shock protein family B (small) member 1 Rattus norvegicus 37-42 30927681-14 2019 On the basis of this research, we concluded that CP/CPPS increases susceptibility to lindane-induced seizures in rats associated with increased level of IL-1beta and IL-6 in the cortex and thalamus. Hexachlorocyclohexane 85-92 interleukin 1 beta Rattus norvegicus 153-161 30927681-14 2019 On the basis of this research, we concluded that CP/CPPS increases susceptibility to lindane-induced seizures in rats associated with increased level of IL-1beta and IL-6 in the cortex and thalamus. Hexachlorocyclohexane 85-92 interleukin 6 Rattus norvegicus 166-170 30820175-9 2019 [3H]EBOB binding data showed that gamma-BHC, its analogs, dieldrin, and other cyclodiene insecticides interact with the same site on GABA receptor as picrotoxinin. Hexachlorocyclohexane 34-43 GABA type A receptor-associated protein Homo sapiens 133-146 30248393-5 2019 The extent of activation of RSKs and HSP25 as measured by western blot from the extent of phosphorylation of IkappaBalpha, p38 MAPK, JNK & HSP25 in lindane-exposed myotubes was higher. Hexachlorocyclohexane 152-159 mitogen activated protein kinase 14 Rattus norvegicus 123-126 30248393-5 2019 The extent of activation of RSKs and HSP25 as measured by western blot from the extent of phosphorylation of IkappaBalpha, p38 MAPK, JNK & HSP25 in lindane-exposed myotubes was higher. Hexachlorocyclohexane 152-159 mitogen-activated protein kinase 8 Rattus norvegicus 133-136 30248393-5 2019 The extent of activation of RSKs and HSP25 as measured by western blot from the extent of phosphorylation of IkappaBalpha, p38 MAPK, JNK & HSP25 in lindane-exposed myotubes was higher. Hexachlorocyclohexane 152-159 heat shock protein family B (small) member 1 Rattus norvegicus 143-148 30248393-7 2019 We conclude that sub-toxic lindane exposure induces oxidative stress, activates RSKs & HSP25 and induces HSP25. Hexachlorocyclohexane 27-34 heat shock protein family B (small) member 1 Rattus norvegicus 91-96 30248393-7 2019 We conclude that sub-toxic lindane exposure induces oxidative stress, activates RSKs & HSP25 and induces HSP25. Hexachlorocyclohexane 27-34 heat shock protein family B (small) member 1 Rattus norvegicus 109-114 29477060-6 2018 A quick (10 min) and complete oxidation of 10 mg L-1 lindane solution and relatively high mineralization degree (80% TOC removal) at 4 h electrolysis were achieved at 8.33 mA cm-2 current density. Hexachlorocyclohexane 53-60 immunoglobulin kappa variable 1-16 Homo sapiens 49-52 30240590-5 2018 Furthermore, treatment with dieldrin and lindane upregulated the cellular expression of Nox1 but not p67phox protein. Hexachlorocyclohexane 41-48 NADPH oxidase 1 Rattus norvegicus 88-92 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Hexachlorocyclohexane 28-35 NADPH oxidase 1 Rattus norvegicus 86-90 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Hexachlorocyclohexane 28-35 NADPH oxidase 1 Rattus norvegicus 158-162 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Hexachlorocyclohexane 187-194 NADPH oxidase 1 Rattus norvegicus 86-90 30240590-8 2018 Treatment with dieldrin and lindane further increased mitochondrial colocalization of Nox1 protein, suggesting a potentially prominent role for mitochondrial Nox1 protein in dieldrin and lindane-induced ROS generation in dopaminergic neurons and its contribution to the combined organochlorinated pesticide-induced neurotoxicity. Hexachlorocyclohexane 187-194 NADPH oxidase 1 Rattus norvegicus 158-162 30031344-8 2018 Lindane also inhibited insulin in T1 and T3 but exhibited consistent effects on the expression changes of daf-2, akt-1 and daf-16. Hexachlorocyclohexane 0-7 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase Caenorhabditis elegans 106-111 30031344-8 2018 Lindane also inhibited insulin in T1 and T3 but exhibited consistent effects on the expression changes of daf-2, akt-1 and daf-16. Hexachlorocyclohexane 0-7 Serine/threonine-protein kinase akt-1 Caenorhabditis elegans 113-118 30031344-8 2018 Lindane also inhibited insulin in T1 and T3 but exhibited consistent effects on the expression changes of daf-2, akt-1 and daf-16. Hexachlorocyclohexane 0-7 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 123-129 30031344-10 2018 Lindane stimulated insulin in T1" and T3" and exhibited consistent effects on expression changes of daf-2, sgk-1 and daf-16 genes that were similar in F0 and F3. Hexachlorocyclohexane 0-7 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase Caenorhabditis elegans 100-105 30031344-10 2018 Lindane stimulated insulin in T1" and T3" and exhibited consistent effects on expression changes of daf-2, sgk-1 and daf-16 genes that were similar in F0 and F3. Hexachlorocyclohexane 0-7 Serine/threonine-protein kinase sgk-1 Caenorhabditis elegans 107-112 30031344-10 2018 Lindane stimulated insulin in T1" and T3" and exhibited consistent effects on expression changes of daf-2, sgk-1 and daf-16 genes that were similar in F0 and F3. Hexachlorocyclohexane 0-7 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 117-123 29074243-3 2018 Sediments from this area, which is highly contaminated with PCBs, HCB, DDTs and gamma-HCH, also activated the zebrafish Pxr (zfPxr) reporter system. Hexachlorocyclohexane 80-89 nuclear receptor subfamily 1, group I, member 2 Danio rerio 120-123 26725215-3 2016 The biosensor was successfully applied for the detection of several important halogenated pollutants under laboratory conditions, e.g., 1,2-dichloroethane, 1,2,3-trichloropropane and gamma-hexachlorocyclohexane, with the limits of detection of 2.7, 1.4 and 12.1mgL(-1), respectively. Hexachlorocyclohexane 183-210 LLGL scribble cell polarity complex component 1 Homo sapiens 261-267 29978130-5 2018 Results: There was a negative correlation between the content of gamma-HCH and C16:1, C17:1, C18:1c9, C18:1c9c12, and SigmaMUFA in cow milk fat and C13:0, C14:0, and C10:1 in mare milk fat. Hexachlorocyclohexane 65-74 Weaning weight-maternal milk Bos taurus 135-139 29978130-5 2018 Results: There was a negative correlation between the content of gamma-HCH and C16:1, C17:1, C18:1c9, C18:1c9c12, and SigmaMUFA in cow milk fat and C13:0, C14:0, and C10:1 in mare milk fat. Hexachlorocyclohexane 65-74 Weaning weight-maternal milk Bos taurus 180-184 29978130-6 2018 A positive correlation was observed between gamma-HCH and C6:0 to C12:0, C14:0, C18:1t16, and SigmaSFA in cow milk fat, and between this compound and C14:0iso, C16:1, C17:1, C18:1c9,11, and SigmaMUFA in mare milk fat. Hexachlorocyclohexane 44-53 Weaning weight-maternal milk Bos taurus 110-114 29978130-6 2018 A positive correlation was observed between gamma-HCH and C6:0 to C12:0, C14:0, C18:1t16, and SigmaSFA in cow milk fat, and between this compound and C14:0iso, C16:1, C17:1, C18:1c9,11, and SigmaMUFA in mare milk fat. Hexachlorocyclohexane 44-53 Weaning weight-maternal milk Bos taurus 208-212 29030126-2 2017 By using an in vitro model of reproductive toxicity consisting of mouse parietal granulosa cells (GCs) exposed to increasing concentrations of Lindane ranging from 1 to 100muM (L1; L10; L100), we aimed to ascertain the Lindane toxicity by evaluating the ultrastructure and expression of the cell death protein p53. Hexachlorocyclohexane 143-150 skull morphology 14 Mus musculus 181-184 28177269-12 2017 Lindane alone and in combination with LPS showed expression of immunopositive Toll-like receptor (TLR)-4 and tumour necrosis factor-alpha (TNF-alpha) positive reaction in various cells of lungs. Hexachlorocyclohexane 0-7 toll-like receptor 4 Mus musculus 98-104 28177269-12 2017 Lindane alone and in combination with LPS showed expression of immunopositive Toll-like receptor (TLR)-4 and tumour necrosis factor-alpha (TNF-alpha) positive reaction in various cells of lungs. Hexachlorocyclohexane 0-7 tumor necrosis factor Mus musculus 139-148 28177269-14 2017 The data indicate that lindane alone or in combination with LPS caused changes in lung morphology and altered TLR-4 and TNF-alpha expression which may have led to altered response to LPS challenge. Hexachlorocyclohexane 23-30 toll-like receptor 4 Mus musculus 110-115 28177269-14 2017 The data indicate that lindane alone or in combination with LPS caused changes in lung morphology and altered TLR-4 and TNF-alpha expression which may have led to altered response to LPS challenge. Hexachlorocyclohexane 23-30 tumor necrosis factor Mus musculus 120-129 26300350-5 2017 A source analysis showed that PBDEs may come from the flame retardant usages of penta-BDE and deca-BDE; hexachlorocyclohexane isomers (HCHs) were from the use of technical HCHs, while DDTs were attributed to early residuals of industrial sources, and PAHs were mainly from pyrolytic sources. Hexachlorocyclohexane 104-125 homeobox D13 Homo sapiens 31-34 27919538-0 2017 Hexachlorocyclohexane - Long term variability and spatial distribution in the Baltic Sea. Hexachlorocyclohexane 0-21 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 85-88 27919538-1 2017 In response to the HELCOM commitment the Leibniz Institute for Baltic Sea Research Warnemuende conducts a monitoring program on listed substances of concern for the Baltic Sea environment which comprises the isomers of technical hexachlorocyclohexane (HCH). Hexachlorocyclohexane 229-250 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 172-175 27919538-4 2017 Mostly, the HCH compounds were evenly distributed in the Baltic Sea. Hexachlorocyclohexane 12-15 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 64-67 27919538-6 2017 Longest residence is shown for beta-HCH, which is currently the predominant HCH isomer in the Baltic Sea (alpha/beta/gamma:1/2/1). Hexachlorocyclohexane 36-39 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 101-104 28088046-5 2017 The AM-PUF has a high efficiency for completely removing (99-100%) of Aldrin, DDT, Endrin, Heptachlor, Heptachlor epoxide and Lindane pesticides in both acidic and alkaline solutions. Hexachlorocyclohexane 126-133 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 7-10 27883041-1 2016 Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin is considered as an important gene for T2DM. Hexachlorocyclohexane 49-71 adiponectin, C1Q and collagen domain containing Homo sapiens 131-137 27883041-1 2016 Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin is considered as an important gene for T2DM. Hexachlorocyclohexane 49-71 adiponectin, C1Q and collagen domain containing Homo sapiens 151-162 27883041-1 2016 Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin is considered as an important gene for T2DM. Hexachlorocyclohexane 73-77 adiponectin, C1Q and collagen domain containing Homo sapiens 151-162 27597971-7 2016 The changes in uterine morphology and positive expression of ERalpha showed inhibition effects between isoflavones and gamma-HCH. Hexachlorocyclohexane 119-128 estrogen receptor 1 Homo sapiens 61-68 27131056-4 2016 The analysis of HCHs, DDTs, and PCBs in mollusks indicates a new usage of lindane, PCB congeners, and the input of technical HCH and aged DDT. Hexachlorocyclohexane 74-81 pyruvate carboxylase Homo sapiens 32-35 25478949-3 2014 Here, we demonstrated the roles of zebrafish Abcc4 in cellular efflux of DDT and lindane. Hexachlorocyclohexane 81-88 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Danio rerio 45-50 26008642-3 2015 In this study, it was observed that 12 milk samples exceeded the maximum residue limits (MRLs) for gamma-HCH (lindane), 18 for DDT and chlorpyrifos, and 1 sample each for endosulfan, cypermethrin, and profenophos. Hexachlorocyclohexane 99-108 Weaning weight-maternal milk Bos taurus 39-43 25674914-2 2015 The linear range for the determination of lindane is up to 700 muM with a limit of detection of 4.8 nM, which is much lower than for other non-enzymatic lindane sensors. Hexachlorocyclohexane 42-49 latexin Homo sapiens 63-66 25674914-2 2015 The linear range for the determination of lindane is up to 700 muM with a limit of detection of 4.8 nM, which is much lower than for other non-enzymatic lindane sensors. Hexachlorocyclohexane 153-160 latexin Homo sapiens 63-66 26023933-5 2015 Epidermal growth factor, 12-O-tetradecanoylphorbol-13-acetate, thrombin receptor activating peptide-6 and lindane regulated GJIC through a MEK1/2-dependent mechanism that was independent of PC-PLC; whereas PAHs, DDT, PCB 153, dicumylperoxide and perfluorodecanoic acid inhibited GJIC through PC-PLC independent of Mek. Hexachlorocyclohexane 106-113 mitogen activated protein kinase kinase 1 Rattus norvegicus 139-145 25478949-5 2014 DDT and lindane were able to induce the expression of abcc4 gene and overexpression of Abcc4 significantly decreased the cytotoxicity and accumulation of DDT and lindane in LLC-PK1 cells and developing embryos. Hexachlorocyclohexane 8-15 multidrug resistance-associated protein 4 Sus scrofa 54-59 25478949-5 2014 DDT and lindane were able to induce the expression of abcc4 gene and overexpression of Abcc4 significantly decreased the cytotoxicity and accumulation of DDT and lindane in LLC-PK1 cells and developing embryos. Hexachlorocyclohexane 8-15 multidrug resistance-associated protein 4 Sus scrofa 87-92 25478949-5 2014 DDT and lindane were able to induce the expression of abcc4 gene and overexpression of Abcc4 significantly decreased the cytotoxicity and accumulation of DDT and lindane in LLC-PK1 cells and developing embryos. Hexachlorocyclohexane 162-169 multidrug resistance-associated protein 4 Sus scrofa 54-59 25478949-5 2014 DDT and lindane were able to induce the expression of abcc4 gene and overexpression of Abcc4 significantly decreased the cytotoxicity and accumulation of DDT and lindane in LLC-PK1 cells and developing embryos. Hexachlorocyclohexane 162-169 multidrug resistance-associated protein 4 Sus scrofa 87-92 25478949-7 2014 Moreover, glutathione (GSH) was involved in the efflux of cellular pesticides and ATPase activity in developing embryos can be induced by DDT or lindane. Hexachlorocyclohexane 145-152 ATPase family AAA domain containing 1a Danio rerio 82-88 25478949-8 2014 Thus, zebrafish Abcc4 plays crucial roles in cellular efflux of organochlorine pesticides and can be used a potential molecular marker for the monitor of DDT and lindane contamination in the aquatic environment. Hexachlorocyclohexane 162-169 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Danio rerio 16-21 22829064-4 2012 The present study aimed at investigating the effects of lindane and chlordecone on cellular processes leading to angiogenesis through an involvement of ERalpha. Hexachlorocyclohexane 56-63 estrogen receptor 1 Homo sapiens 152-159 24216264-11 2014 To find out the dependence of blood OCPs level on genotype, we carried out logistic regression analysis and results revealed that GSTM1(-)/GSTT1(-) genotype associated significantly with a number of OCPs namely gamma-HCH, p,p"-DDT and total pesticides. Hexachlorocyclohexane 211-220 glutathione S-transferase mu 1 Homo sapiens 130-135 24216264-11 2014 To find out the dependence of blood OCPs level on genotype, we carried out logistic regression analysis and results revealed that GSTM1(-)/GSTT1(-) genotype associated significantly with a number of OCPs namely gamma-HCH, p,p"-DDT and total pesticides. Hexachlorocyclohexane 211-220 glutathione S-transferase theta 1 Homo sapiens 139-144 23918254-7 2014 There was a statistically significant (p < 0.05) negative correlation between the concentration of lindane, DDTs and PCBs (as a sum of indicator congeners) in the liver and in the activity of GST. Hexachlorocyclohexane 102-109 microsomal glutathione S-transferase 1 Sus scrofa 195-198 24555676-8 2014 Data demonstrated a significant relation between AChE activity inhibition and presence of endosulfan II, gamma-HCH, copper, lead, and 4,4-DDE, as well as between AChE and GST activity at different sites. Hexachlorocyclohexane 105-114 acetylcholinesterase Crassostrea gigas 49-53 24380025-6 2013 When gene environmental interaction between the CYP17 gene polymorphism and OCPs level was considered, a significant interaction was observed between >= 50th percentile of gamma-HCH and CYP17 A1A1 (wild type) genotype. Hexachlorocyclohexane 175-184 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 48-53 24380025-6 2013 When gene environmental interaction between the CYP17 gene polymorphism and OCPs level was considered, a significant interaction was observed between >= 50th percentile of gamma-HCH and CYP17 A1A1 (wild type) genotype. Hexachlorocyclohexane 175-184 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 189-194 24135568-2 2013 Lindane caused the loss of stress-protective chaperone GroEL, and inhibited photosynthesis, respiration and nitrogen-fixation in Anabaena, resulting in growth arrest. Hexachlorocyclohexane 0-7 GroEL Escherichia coli 55-60 23927878-7 2013 Similarities were also observed in activation of ERK and JNK MAP kinases and c-jun in PBL or brain isolated from rats treated with lindane. Hexachlorocyclohexane 131-138 mitogen-activated protein kinase 8 Rattus norvegicus 57-60 23299500-9 2013 Two gap junction blockers, lindane and carbenoxolone (CBX), significantly decreased the amplitude of Per2 oscillations, which further adhered significant decreases in Per2 and Rev-erbalpha transcript levels. Hexachlorocyclohexane 27-34 period circadian regulator 2 Rattus norvegicus 101-105 23299500-9 2013 Two gap junction blockers, lindane and carbenoxolone (CBX), significantly decreased the amplitude of Per2 oscillations, which further adhered significant decreases in Per2 and Rev-erbalpha transcript levels. Hexachlorocyclohexane 27-34 period circadian regulator 2 Rattus norvegicus 167-171 23299500-9 2013 Two gap junction blockers, lindane and carbenoxolone (CBX), significantly decreased the amplitude of Per2 oscillations, which further adhered significant decreases in Per2 and Rev-erbalpha transcript levels. Hexachlorocyclohexane 27-34 nuclear receptor subfamily 1, group D, member 1 Rattus norvegicus 176-188 23299500-10 2013 In addition, both lindane and CBX induced a clear phase-delay shift of Per2 oscillations. Hexachlorocyclohexane 18-25 period circadian regulator 2 Rattus norvegicus 71-75 22677539-2 2012 Under our experimental conditions, lindane poisoning (5mg/kg body weight per day for 3 days) resulted in (1) an increased level of plasma glucose, cholesterol and triglycerides, (2) an increased activity of LDH, ALP, AST, ALT, (3) an oxidative stress in liver and brain as revealed by an increased level of lipids peroxidation (TBARS) and a decrease of glutathione-peroxidase, superoxide dismutase and catalase activities in liver and brain. Hexachlorocyclohexane 35-42 catalase Rattus norvegicus 402-410 22677539-3 2012 In conclusion, both Vit C+E or Mg+Zn treatments display beneficial effects upon oxidative stress induced by lindane treatment in liver and brain. Hexachlorocyclohexane 108-115 vitrin Rattus norvegicus 20-23 22055446-6 2012 This shift of burdens exceeds the sea ice burden by a factor of 8 for gamma-HCH and by a factor of 15 for DDT. Hexachlorocyclohexane 71-80 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 34-37 22676433-3 2012 Cross-linking in styrene-divinylbenzene copolymer (PS2) created substantial surface area and porosity, thus, K(oc) values of phenanthrene, lindane, naphthalene, and 1-naphthol by PS2 were as high as 274.8, 212.3, 27.4, and 1.5 times of those by the linear polystyrene (PS1). Hexachlorocyclohexane 139-146 taste 2 receptor member 64 pseudogene Homo sapiens 51-54 22676433-4 2012 The K(oc) values of lindane, naphthalene, and 1-naphthol by polar PPO were approximately 1-3 orders of magnitude higher than those by PS1, and PPO had comparable sorption for phenanthrene but higher sorption for naphthalene and 1-naphthol than PS2. Hexachlorocyclohexane 20-27 taste 2 receptor member 62 pseudogene Homo sapiens 134-137 22676433-4 2012 The K(oc) values of lindane, naphthalene, and 1-naphthol by polar PPO were approximately 1-3 orders of magnitude higher than those by PS1, and PPO had comparable sorption for phenanthrene but higher sorption for naphthalene and 1-naphthol than PS2. Hexachlorocyclohexane 20-27 taste 2 receptor member 64 pseudogene Homo sapiens 244-247 22302394-7 2012 Administration of Lindane induced histopathological alterations and increased levels of serum hepatic and renal markers and malondialdehyde (MDA) with a significant decrease in GSH content and CAT, SOD, GPx and GST activities. Hexachlorocyclohexane 18-25 hematopoietic prostaglandin D synthase Rattus norvegicus 211-214 22531938-9 2012 CYP3A5, PON2, PON3, CMBL, PON1, ALPL, CYP3A43, CYP3A7, ACP6, ACPP, and ALPI (p < 0.05) are involved in the pathway of gamma-hexachlorocyclohexane degradation. Hexachlorocyclohexane 121-148 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 0-6 22720419-2 2012 An ozone dosage of 57 mg min(-1) was found to be optimal for the degradation of both endosulfan (89%) and lindane (43%). Hexachlorocyclohexane 106-113 CD59 molecule (CD59 blood group) Homo sapiens 25-31 22720419-7 2012 While for initial lindane concentrations of 5, 7.5 and 10 ppm, the observed rate constants were 0.0243, 0.0333 and 0.056 min(-1), respectively. Hexachlorocyclohexane 18-25 CD59 molecule (CD59 blood group) Homo sapiens 121-127 22208189-5 2011 The most potent compound was lindane, a GABA(A) receptor antagonist, with an IC50 of 0.2 muM. Hexachlorocyclohexane 29-36 latexin Homo sapiens 89-92 22214240-7 2012 HCH exposure markedly increased the percentages of CD3(+)CD4(+) T-lymphocytes and expression of CD45RO(+) on CD4(+) and CD8(+) T-lymphocytes, but decreased CD4(+)CD25(+) T-lymphocytes in SLE patients. Hexachlorocyclohexane 0-3 CD4 molecule Homo sapiens 57-60 22214240-7 2012 HCH exposure markedly increased the percentages of CD3(+)CD4(+) T-lymphocytes and expression of CD45RO(+) on CD4(+) and CD8(+) T-lymphocytes, but decreased CD4(+)CD25(+) T-lymphocytes in SLE patients. Hexachlorocyclohexane 0-3 protein tyrosine phosphatase receptor type C Homo sapiens 96-100 22214240-7 2012 HCH exposure markedly increased the percentages of CD3(+)CD4(+) T-lymphocytes and expression of CD45RO(+) on CD4(+) and CD8(+) T-lymphocytes, but decreased CD4(+)CD25(+) T-lymphocytes in SLE patients. Hexachlorocyclohexane 0-3 CD4 molecule Homo sapiens 96-99 22214240-7 2012 HCH exposure markedly increased the percentages of CD3(+)CD4(+) T-lymphocytes and expression of CD45RO(+) on CD4(+) and CD8(+) T-lymphocytes, but decreased CD4(+)CD25(+) T-lymphocytes in SLE patients. Hexachlorocyclohexane 0-3 CD8a molecule Homo sapiens 120-123 22214240-7 2012 HCH exposure markedly increased the percentages of CD3(+)CD4(+) T-lymphocytes and expression of CD45RO(+) on CD4(+) and CD8(+) T-lymphocytes, but decreased CD4(+)CD25(+) T-lymphocytes in SLE patients. Hexachlorocyclohexane 0-3 CD4 molecule Homo sapiens 96-99 22214240-7 2012 HCH exposure markedly increased the percentages of CD3(+)CD4(+) T-lymphocytes and expression of CD45RO(+) on CD4(+) and CD8(+) T-lymphocytes, but decreased CD4(+)CD25(+) T-lymphocytes in SLE patients. Hexachlorocyclohexane 0-3 interleukin 2 receptor subunit alpha Homo sapiens 162-166 22214240-10 2012 Further, both HCH and DDT decreased the levels of IL-2 and IFNgamma but had no effect on IL-4 levels in SLE patients. Hexachlorocyclohexane 14-17 interleukin 2 Homo sapiens 50-67 22001173-4 2011 In this study, we demonstrate that lindane up-regulates PKC by increasing oxidative stress. Hexachlorocyclohexane 35-42 protein kinase C, gamma Rattus norvegicus 56-59 22001173-6 2011 Thus, these findings indicate that several dependent key signalling pathways, including detoxification, apoptosis, PKC activity and redox status maintenance, contribute to lindane-induced toxicity in primary cultured rat hepatocytes. Hexachlorocyclohexane 172-179 protein kinase C, gamma Rattus norvegicus 115-118 21458603-0 2011 Expression of a human cytochrome P4502E1 in Nicotiana tabacum enhances tolerance and remediation of gamma-hexachlorocyclohexane. Hexachlorocyclohexane 100-127 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 22-40 21484269-9 2011 Contribution analysis showed that dibenz[a,h]anthracene contributed most to the carcinogenic risk in XZ city, and alpha-HCH, beta-HCH and gamma-HCH posed the most carcinogenic risk in tap water from GoHu (GH) in Eastern Taihu Lake. Hexachlorocyclohexane 138-147 nuclear RNA export factor 1 Homo sapiens 184-187 21458603-4 2011 Here, we report the development of transgenic tobacco plants expressing human CYP2E1 and the efficacy of plants for remediation of lindane. Hexachlorocyclohexane 131-138 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 78-84 21458603-5 2011 Transgenic tobacco plants with CYP2E1 showed enhanced tolerance to lindane when grown in hydroponic medium and soil compared to control plants. Hexachlorocyclohexane 67-74 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 31-37 21458603-8 2011 The present study has shown that transgenic plants expressing CYP2E1 gene have potential use for remediation of lindane from contaminated solutions and soil. Hexachlorocyclohexane 112-119 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 62-68 21219962-8 2011 Co-treatment of gallic acid significantly prevented the lindane induced alterations in kidney and liver tissues with a decrease in LPO, serum marker enzyme activity and a significant increase in antioxidant levels. Hexachlorocyclohexane 56-63 lactoperoxidase Rattus norvegicus 131-134 21452598-14 2011 Lindane treated group showed increased lipid peroxidation, whereas glutathione, glutathione peroxidase, superoxide dismutase, catalase and protein were significantly decreased compared to control. Hexachlorocyclohexane 0-7 catalase Mus musculus 126-134 21278053-9 2011 Lindane did not activate these pathways, but it inhibited estradiol-mediated Akt and ERK1/2 activation. Hexachlorocyclohexane 0-7 AKT serine/threonine kinase 1 Homo sapiens 77-80 21278053-9 2011 Lindane did not activate these pathways, but it inhibited estradiol-mediated Akt and ERK1/2 activation. Hexachlorocyclohexane 0-7 mitogen-activated protein kinase 3 Homo sapiens 85-91 20643100-6 2010 Further, treatment with the ROS-inducer gamma-hexa-chloro-cyclohexane (gamma-HCH, lindane), an inhibitor of GAP junctions, restored nuclear translocation of TPPII in these cell lines upon gamma-irradiation. Hexachlorocyclohexane 71-80 tripeptidyl peptidase 2 Homo sapiens 157-162 20663516-10 2010 Treatment of lindane to normal control animals resulted in a significant decrease in AChE, BChE and ATPase levels in crude homogenates of cerebellum and pons-medulla. Hexachlorocyclohexane 13-20 acetylcholinesterase Mus musculus 85-89 20663516-10 2010 Treatment of lindane to normal control animals resulted in a significant decrease in AChE, BChE and ATPase levels in crude homogenates of cerebellum and pons-medulla. Hexachlorocyclohexane 13-20 butyrylcholinesterase Mus musculus 91-95 21175351-5 2011 The number of phosphorylated ATM foci in MRC-5 cells treated with lindane, an inhibitor of radiation-induced bystander effects, prior to X irradiation was assessed; phosphorylated ATM foci were not observed at 5 h (20 mGy) or 24 h (200 mGy) postirradiation. Hexachlorocyclohexane 66-73 ATM serine/threonine kinase Homo sapiens 29-32 21175351-5 2011 The number of phosphorylated ATM foci in MRC-5 cells treated with lindane, an inhibitor of radiation-induced bystander effects, prior to X irradiation was assessed; phosphorylated ATM foci were not observed at 5 h (20 mGy) or 24 h (200 mGy) postirradiation. Hexachlorocyclohexane 66-73 ATM serine/threonine kinase Homo sapiens 180-183 20643100-6 2010 Further, treatment with the ROS-inducer gamma-hexa-chloro-cyclohexane (gamma-HCH, lindane), an inhibitor of GAP junctions, restored nuclear translocation of TPPII in these cell lines upon gamma-irradiation. Hexachlorocyclohexane 82-89 tripeptidyl peptidase 2 Homo sapiens 157-162 20182699-4 2010 There was (p < 0.01) decline in superoxide dismutase, catalase and glutathione-s-transferase activity on lindane exposure, however, no change (p > 0.05) was observed in glutathione level. Hexachlorocyclohexane 108-115 catalase Rattus norvegicus 57-65 20860975-4 2010 In general, higher PCB levels are found in samples from urban locations, pesticides levels are higher in samples from locations where has been their probable usage in agriculture, while HCB levels are usually indicator of industrial activity.gamma-HCH has been found in the highest concentration in air and pine needles samples, while in humans DDE and beta-HCH are the most abundant compounds. Hexachlorocyclohexane 242-251 pyruvate carboxylase Homo sapiens 19-22 20182699-4 2010 There was (p < 0.01) decline in superoxide dismutase, catalase and glutathione-s-transferase activity on lindane exposure, however, no change (p > 0.05) was observed in glutathione level. Hexachlorocyclohexane 108-115 hematopoietic prostaglandin D synthase Rattus norvegicus 70-95 20036686-6 2010 Mechanistically, dieldrin and lindane combination induced a rapid increase in the levels of intracellular reactive oxygen species, a decrease in mitochondrial membrane potential and activation of caspase 3/7. Hexachlorocyclohexane 30-37 caspase 3 Rattus norvegicus 196-205 20455324-1 2010 Acute dose of lindane (40 mg/kg body weight, ip) caused significant reduction in butyrylcholinesterase (BChE) activity both in olfactory lobe and cerebrum of mice along with reduction in catalase (CAT), total protein and elevation in superoxide dismutase (SOD) and cholesterol contents. Hexachlorocyclohexane 14-21 butyrylcholinesterase Mus musculus 81-102 20455324-1 2010 Acute dose of lindane (40 mg/kg body weight, ip) caused significant reduction in butyrylcholinesterase (BChE) activity both in olfactory lobe and cerebrum of mice along with reduction in catalase (CAT), total protein and elevation in superoxide dismutase (SOD) and cholesterol contents. Hexachlorocyclohexane 14-21 butyrylcholinesterase Mus musculus 104-108 20455324-1 2010 Acute dose of lindane (40 mg/kg body weight, ip) caused significant reduction in butyrylcholinesterase (BChE) activity both in olfactory lobe and cerebrum of mice along with reduction in catalase (CAT), total protein and elevation in superoxide dismutase (SOD) and cholesterol contents. Hexachlorocyclohexane 14-21 catalase Mus musculus 187-195 20455324-1 2010 Acute dose of lindane (40 mg/kg body weight, ip) caused significant reduction in butyrylcholinesterase (BChE) activity both in olfactory lobe and cerebrum of mice along with reduction in catalase (CAT), total protein and elevation in superoxide dismutase (SOD) and cholesterol contents. Hexachlorocyclohexane 14-21 catalase Mus musculus 197-200 19818741-8 2010 HCH lead to apoptotic as well as necrotic cell death as it was marked by increased caspase-3 activity and lactate dehydrogenase (LDH) leakage, respectively. Hexachlorocyclohexane 0-3 caspase 3 Mus musculus 83-92 19557771-0 2009 Effect of lindane on CYP-mediated steroid hormone metabolism in male mice following in utero exposure. Hexachlorocyclohexane 10-17 peptidyl-prolyl isomerase G (cyclophilin G) Mus musculus 21-24 19038305-0 2009 Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas-FasL and mitochondria-dependent pathways. Hexachlorocyclohexane 0-7 Fas ligand Rattus norvegicus 89-93 19221147-4 2009 Further experiments showed that in such model, lindane induced features of apoptotic cell death in PGCs such as increase in caspase-3 activity, poly-ADP-ribose polymerase cleavage, and terminal dUTP nick-end labeling (TUNEL) positivity. Hexachlorocyclohexane 47-54 caspase 3 Mus musculus 124-133 19221147-4 2009 Further experiments showed that in such model, lindane induced features of apoptotic cell death in PGCs such as increase in caspase-3 activity, poly-ADP-ribose polymerase cleavage, and terminal dUTP nick-end labeling (TUNEL) positivity. Hexachlorocyclohexane 47-54 poly (ADP-ribose) polymerase family, member 1 Mus musculus 144-170 19221147-6 2009 Finally, we show that a brief incubation of isolated PGCs with 10(-5)M lindane resulted in a marked decrease of the basal and kit-ligand-induced phosphorylation level of the AKT kinase, known to be crucial for PGC survival. Hexachlorocyclohexane 71-78 thymoma viral proto-oncogene 1 Mus musculus 174-177 19221147-7 2009 Taken together these results demonstrate that embryo exposure to lindane during early stages of gametogenesis can severely impair the number of germ cells in the fetal gonads; the compound appears to affect PGC survival through a direct proapoptotic action likely resulting from its adverse effect on AKT activity in such cells. Hexachlorocyclohexane 65-72 thymoma viral proto-oncogene 1 Mus musculus 301-304 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 annexin A3 Rattus norvegicus 135-138 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 RAB7A, member RAS oncogene family Rattus norvegicus 140-144 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 lysosomal-associated membrane protein 1 Rattus norvegicus 149-154 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 annexin A3 Rattus norvegicus 230-233 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 annexin A3 Rattus norvegicus 230-233 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 beclin 1 Rattus norvegicus 315-323 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 Bcl2-like 1 Rattus norvegicus 381-387 19041923-4 2009 We found that lindane deregulated the autophagic process as demonstrated by (1) the formation of enlarged acidic vesicles labeled with LC3, Rab7 and LAMP1 (specific markers of autophagic vacuole maturation), (2) the conversion of LC3-I (the cytosolic form) into LC3-II (membrane bound), (3) the deregulation of the Beclin 1 protein expression and (4) the enhanced formation of the Bcl-xL/Beclin 1 complex. Hexachlorocyclohexane 14-21 beclin 1 Rattus norvegicus 388-396 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 162-189 Rous sarcoma oncogene Mus musculus 73-76 19893075-0 2009 Acetylcholinesterase as a potential target of acute neurotoxic effects of lindane in rats. Hexachlorocyclohexane 74-81 acetylcholinesterase Rattus norvegicus 0-20 19893075-1 2009 The aim of our study was to investigate the possible involvement of acetylcholinesterase (AchE) in mediating the early phase of acute lindane neurotoxicity in rats. Hexachlorocyclohexane 134-141 acetylcholinesterase Rattus norvegicus 68-88 19893075-1 2009 The aim of our study was to investigate the possible involvement of acetylcholinesterase (AchE) in mediating the early phase of acute lindane neurotoxicity in rats. Hexachlorocyclohexane 134-141 acetylcholinesterase Rattus norvegicus 90-94 19893075-11 2009 In contrast, activity of synaptosomal AchE fraction was significantly increased only in thalamus 4 h after lindane administration (p < 0.05). Hexachlorocyclohexane 107-114 acetylcholinesterase Rattus norvegicus 38-42 19893075-12 2009 An increase in AchE activity may be involved in mediating acute neurotoxic effects of lindane, at least in some brain structures in rats. Hexachlorocyclohexane 86-93 acetylcholinesterase Rattus norvegicus 15-19 19776659-0 2009 Influence of NR2B-selective NMDA antagonist on lindane-induced seizures in rats. Hexachlorocyclohexane 47-54 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 13-17 19776659-14 2009 These results indicate that ifenprodil alleviates behavioral seizures and modifies EEG characteristics of lindane seizures in rats, thus showing the involvement of NMDA receptors containing the NR2B subunit in the mechanisms of lindane convulsions. Hexachlorocyclohexane 228-235 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 194-198 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 162-189 tight junction protein 1 Mus musculus 78-82 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 162-189 gap junction protein, alpha 1 Mus musculus 87-91 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 162-189 gap junction protein, alpha 1 Mus musculus 99-103 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 191-194 Rous sarcoma oncogene Mus musculus 73-76 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 191-194 tight junction protein 1 Mus musculus 78-82 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 191-194 gap junction protein, alpha 1 Mus musculus 87-91 19033388-3 2008 Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen gamma-hexachlorocyclohexane (HCH). Hexachlorocyclohexane 191-194 gap junction protein, alpha 1 Mus musculus 99-103 19033388-5 2008 HCH induced the rapid recruitment of Src to the plasma membrane, activation of Src within 3 minutes and the efficient inhibition of gap junctional coupling, but had no effect in the presence of the Src inhibitor PP2. Hexachlorocyclohexane 0-3 Rous sarcoma oncogene Mus musculus 37-40 19033388-5 2008 HCH induced the rapid recruitment of Src to the plasma membrane, activation of Src within 3 minutes and the efficient inhibition of gap junctional coupling, but had no effect in the presence of the Src inhibitor PP2. Hexachlorocyclohexane 0-3 Rous sarcoma oncogene Mus musculus 79-82 19033388-5 2008 HCH induced the rapid recruitment of Src to the plasma membrane, activation of Src within 3 minutes and the efficient inhibition of gap junctional coupling, but had no effect in the presence of the Src inhibitor PP2. Hexachlorocyclohexane 0-3 Rous sarcoma oncogene Mus musculus 79-82 19033388-6 2008 Immunoprecipitation experiments demonstrated that HCH increased Cx43-Src interaction and concomitantly decreased Cx43-ZO-1 association. Hexachlorocyclohexane 50-53 gap junction protein, alpha 1 Mus musculus 64-68 19033388-6 2008 Immunoprecipitation experiments demonstrated that HCH increased Cx43-Src interaction and concomitantly decreased Cx43-ZO-1 association. Hexachlorocyclohexane 50-53 Rous sarcoma oncogene Mus musculus 69-72 19033388-6 2008 Immunoprecipitation experiments demonstrated that HCH increased Cx43-Src interaction and concomitantly decreased Cx43-ZO-1 association. Hexachlorocyclohexane 50-53 gap junction protein, alpha 1 Mus musculus 113-117 19033388-6 2008 Immunoprecipitation experiments demonstrated that HCH increased Cx43-Src interaction and concomitantly decreased Cx43-ZO-1 association. Hexachlorocyclohexane 50-53 tight junction protein 1 Mus musculus 118-122 19033388-7 2008 ZO-1 was detected on both sides of the gap junction plaques in untreated cells, but appeared to be mainly localized on one side during HCH-induced internalization. Hexachlorocyclohexane 135-138 tight junction protein 1 Mus musculus 0-4 19033388-9 2008 These findings provide mechanistic evidence by which internalization of the Cx43 gap junction plaque might be initiated, suggesting that Src-mediated dissociation of ZO-1 from one side of the plaque initiates endocytic internalization of gap junctions and that this process is amplified in response to exposure to HCH. Hexachlorocyclohexane 314-317 gap junction protein, alpha 1 Mus musculus 76-80 19033388-9 2008 These findings provide mechanistic evidence by which internalization of the Cx43 gap junction plaque might be initiated, suggesting that Src-mediated dissociation of ZO-1 from one side of the plaque initiates endocytic internalization of gap junctions and that this process is amplified in response to exposure to HCH. Hexachlorocyclohexane 314-317 Rous sarcoma oncogene Mus musculus 137-140 19033388-9 2008 These findings provide mechanistic evidence by which internalization of the Cx43 gap junction plaque might be initiated, suggesting that Src-mediated dissociation of ZO-1 from one side of the plaque initiates endocytic internalization of gap junctions and that this process is amplified in response to exposure to HCH. Hexachlorocyclohexane 314-317 tight junction protein 1 Mus musculus 166-170 18248869-3 2008 To get more insight into the mechanism(s) involved in gonadal effect(s) of lindane, we sought to investigate whether treatment with lindane at a low dose would alter the levels of steroidogenic acute regulatory protein (StAR), androgen binding protein (ABP) and activities of steroidogenic enzymes (3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase) in adult rat. Hexachlorocyclohexane 75-82 steroidogenic acute regulatory protein Rattus norvegicus 220-224 19174875-7 2008 The rate of concentration increase, expressed quantitatively through the slope of the linear regression between the logarithm of the concentrations and altitude, increases along the sequence HCB < PCB < HCH < or = DDT. Hexachlorocyclohexane 209-212 pyruvate carboxylase Homo sapiens 200-203 18665982-3 2008 Although gamma -HCH at high concentration did not have an effect on cell viability and apoptosis, DNA fragmentation was slightly enhanced, and apoptotic factors; Bax, Bad, cytochrome c and caspase-3 showed tendency to increase by the addition of a low dose of gamma-HCH to the cell medium. Hexachlorocyclohexane 9-19 BCL2 associated X, apoptosis regulator Rattus norvegicus 162-165 18665982-3 2008 Although gamma -HCH at high concentration did not have an effect on cell viability and apoptosis, DNA fragmentation was slightly enhanced, and apoptotic factors; Bax, Bad, cytochrome c and caspase-3 showed tendency to increase by the addition of a low dose of gamma-HCH to the cell medium. Hexachlorocyclohexane 9-19 caspase 3 Rattus norvegicus 189-198 18040759-5 2008 Using phosphorylation site-specific antibodies, we demonstrated that lindane, dieldrin, and ChK all activated p44/42 ERK, but only ChK activated Akt kinase. Hexachlorocyclohexane 69-76 mitogen activated protein kinase 3 Rattus norvegicus 110-113 18040759-5 2008 Using phosphorylation site-specific antibodies, we demonstrated that lindane, dieldrin, and ChK all activated p44/42 ERK, but only ChK activated Akt kinase. Hexachlorocyclohexane 69-76 Eph receptor B1 Rattus norvegicus 117-120 18763860-5 2008 Moreover, the number of DSBs obtained by subtracting the number of phosphorylated ATM foci in lindane-treated cells from the number of phosphorylated ATM foci in untreated cells was proportional to the dose at low doses (1.2-5 mGy) and was saturated at doses from 10-200 mGy. Hexachlorocyclohexane 94-101 ATM serine/threonine kinase Homo sapiens 82-85 18763860-5 2008 Moreover, the number of DSBs obtained by subtracting the number of phosphorylated ATM foci in lindane-treated cells from the number of phosphorylated ATM foci in untreated cells was proportional to the dose at low doses (1.2-5 mGy) and was saturated at doses from 10-200 mGy. Hexachlorocyclohexane 94-101 ATM serine/threonine kinase Homo sapiens 150-153 18486174-8 2008 Prenatal exposure to lindane was found to produce an increase in the mRNA and protein expression of CYP1A1, 1A2, 2B1, 2B2 isoforms in brain and liver of the offspring at postnatal day 50. Hexachlorocyclohexane 21-28 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 100-106 18248869-3 2008 To get more insight into the mechanism(s) involved in gonadal effect(s) of lindane, we sought to investigate whether treatment with lindane at a low dose would alter the levels of steroidogenic acute regulatory protein (StAR), androgen binding protein (ABP) and activities of steroidogenic enzymes (3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase) in adult rat. Hexachlorocyclohexane 132-139 steroidogenic acute regulatory protein Rattus norvegicus 180-218 18248869-3 2008 To get more insight into the mechanism(s) involved in gonadal effect(s) of lindane, we sought to investigate whether treatment with lindane at a low dose would alter the levels of steroidogenic acute regulatory protein (StAR), androgen binding protein (ABP) and activities of steroidogenic enzymes (3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase) in adult rat. Hexachlorocyclohexane 132-139 steroidogenic acute regulatory protein Rattus norvegicus 220-224 18248869-3 2008 To get more insight into the mechanism(s) involved in gonadal effect(s) of lindane, we sought to investigate whether treatment with lindane at a low dose would alter the levels of steroidogenic acute regulatory protein (StAR), androgen binding protein (ABP) and activities of steroidogenic enzymes (3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase) in adult rat. Hexachlorocyclohexane 132-139 sex hormone binding globulin Rattus norvegicus 227-251 18248869-3 2008 To get more insight into the mechanism(s) involved in gonadal effect(s) of lindane, we sought to investigate whether treatment with lindane at a low dose would alter the levels of steroidogenic acute regulatory protein (StAR), androgen binding protein (ABP) and activities of steroidogenic enzymes (3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase) in adult rat. Hexachlorocyclohexane 132-139 sex hormone binding globulin Rattus norvegicus 253-256 18248869-3 2008 To get more insight into the mechanism(s) involved in gonadal effect(s) of lindane, we sought to investigate whether treatment with lindane at a low dose would alter the levels of steroidogenic acute regulatory protein (StAR), androgen binding protein (ABP) and activities of steroidogenic enzymes (3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase) in adult rat. Hexachlorocyclohexane 132-139 aldo-keto reductase family 1, member C12 Rattus norvegicus 338-373 18248869-7 2008 Administration of lindane resulted in a sequential reduction in the levels of StAR and the activities of steroidogenic enzymes with a parallel increase in the levels of H2O2. Hexachlorocyclohexane 18-25 steroidogenic acute regulatory protein Rattus norvegicus 78-82 18174961-10 2007 Treatment with a binary mixture of 10(-8) M B[a]P plus 10(-12) M lindane or 10(-10) M E(2) reversed B[a]P-induced reductions in the ratio of Bcl-2- to Bax-positive cells. Hexachlorocyclohexane 65-72 BCL2 associated X, apoptosis regulator Homo sapiens 151-154 17620312-4 2008 Treatment of these cells with lindane, a general gap junction blocker, or expression of dominant negative Cx43 increased apoptotic cell death and decreased the level of integrin beta4 protein, in a manner similar to that observed when these cells were exposed to TGF-beta3. Hexachlorocyclohexane 30-37 integrin subunit beta 4 Gallus gallus 169-183 17620312-4 2008 Treatment of these cells with lindane, a general gap junction blocker, or expression of dominant negative Cx43 increased apoptotic cell death and decreased the level of integrin beta4 protein, in a manner similar to that observed when these cells were exposed to TGF-beta3. Hexachlorocyclohexane 30-37 transforming growth factor beta 3 Gallus gallus 263-272 17984293-4 2008 Moreover, due to its lipophilic nature, lindane may partition in mother"s milk leading to further exposure of the offspring during the critical period of neurodevelopment which may explain the increase in CYP mRNA expression and associated catalytic activity especially during the early postnatal period. Hexachlorocyclohexane 40-47 peptidylprolyl isomerase G Homo sapiens 205-208 17984293-5 2008 Interestingly, the increase in mRNA expression of these CYP isoforms was found to persist up to adulthood, suggesting that the low doses of lindane administered to the dams might program the brain and liver of the offspring to persistently express the xenobiotic-metabolizing CYP isoforms. Hexachlorocyclohexane 140-147 peptidylprolyl isomerase G Homo sapiens 56-59 17984293-5 2008 Interestingly, the increase in mRNA expression of these CYP isoforms was found to persist up to adulthood, suggesting that the low doses of lindane administered to the dams might program the brain and liver of the offspring to persistently express the xenobiotic-metabolizing CYP isoforms. Hexachlorocyclohexane 140-147 peptidylprolyl isomerase G Homo sapiens 276-279 17984293-6 2008 As CYP-dependent metabolism of lindane is involved in its neurobehavioral toxicity, the potential of lindane to imprint the expression of cerebral and hepatic CYPs may help in identifying the role of these enzymes in the developmental neurotoxicity of the pesticide. Hexachlorocyclohexane 31-38 peptidylprolyl isomerase G Homo sapiens 3-6 17984293-6 2008 As CYP-dependent metabolism of lindane is involved in its neurobehavioral toxicity, the potential of lindane to imprint the expression of cerebral and hepatic CYPs may help in identifying the role of these enzymes in the developmental neurotoxicity of the pesticide. Hexachlorocyclohexane 101-108 peptidylprolyl isomerase G Homo sapiens 3-6 17997001-0 2008 Lindane alters the levels of HSP70 and clusterin in adult rat testis. Hexachlorocyclohexane 0-7 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 29-34 17997001-0 2008 Lindane alters the levels of HSP70 and clusterin in adult rat testis. Hexachlorocyclohexane 0-7 clusterin Rattus norvegicus 39-48 17997001-2 2008 To get more insight into the mechanism(s) involved in gonadal effect(s) of lindane, we sought to investigate whether treatment with lindane would alter the levels of stress proteins (heat shock proteins and clusterin) and change oxidative stress-related parameters (antioxidant enzymes and lipid peroxidation) in the testis of adult male rats. Hexachlorocyclohexane 132-139 clusterin Rattus norvegicus 207-216 17997001-5 2008 Administration of lindane resulted in a sequential reduction in the activities of catalase and superoxide dismutase (SOD) with concomitant increase in the levels of lipid peroxidation. Hexachlorocyclohexane 18-25 catalase Rattus norvegicus 82-90 18174961-11 2007 In contrast, treatments with PhIP (known to possess hormonelike properties) plus lindane or E(2) resulted in profound reductions in Bcl-2:Bax ratio. Hexachlorocyclohexane 81-88 BCL2 apoptosis regulator Homo sapiens 132-137 18174961-11 2007 In contrast, treatments with PhIP (known to possess hormonelike properties) plus lindane or E(2) resulted in profound reductions in Bcl-2:Bax ratio. Hexachlorocyclohexane 81-88 BCL2 associated X, apoptosis regulator Homo sapiens 138-141 16838206-6 2006 Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). Hexachlorocyclohexane 12-15 microsomal glutathione S-transferase 1 Sus scrofa 65-90 18174961-8 2007 Lindane increased the ratio of Bcl-2:Bax, as did 17beta-estradiol (E(2)). Hexachlorocyclohexane 0-7 BCL2 apoptosis regulator Homo sapiens 31-36 18174961-8 2007 Lindane increased the ratio of Bcl-2:Bax, as did 17beta-estradiol (E(2)). Hexachlorocyclohexane 0-7 BCL2 associated X, apoptosis regulator Homo sapiens 37-40 18174961-10 2007 Treatment with a binary mixture of 10(-8) M B[a]P plus 10(-12) M lindane or 10(-10) M E(2) reversed B[a]P-induced reductions in the ratio of Bcl-2- to Bax-positive cells. Hexachlorocyclohexane 65-72 BCL2 apoptosis regulator Homo sapiens 141-146 17123163-8 2006 The pre-feeding of AL resulted in the reversal of HCH-induced alteration in GSH-Px and G-6-PDH activities. Hexachlorocyclohexane 50-53 glucose-6-phosphate dehydrogenase Rattus norvegicus 87-94 17123163-9 2006 The significant reduction in the level of glutathione S-transferase brought about by HCH was restored to control level by feeding 20% AL. Hexachlorocyclohexane 85-88 hematopoietic prostaglandin D synthase Rattus norvegicus 42-67 17080404-9 2006 It was demonstrated that lindane reduced cortisol secretion, downregulated the expression of a subset of the genes encoding steroidogenic enzymes and repressed transcriptional activation of the steroidogenic acute regulatory protein (StAR) gene promoter. Hexachlorocyclohexane 25-32 steroidogenic acute regulatory protein Homo sapiens 194-232 17080404-9 2006 It was demonstrated that lindane reduced cortisol secretion, downregulated the expression of a subset of the genes encoding steroidogenic enzymes and repressed transcriptional activation of the steroidogenic acute regulatory protein (StAR) gene promoter. Hexachlorocyclohexane 25-32 steroidogenic acute regulatory protein Homo sapiens 234-238 17537412-0 2007 Lindane may modulate the female reproductive development through the interaction with ER-beta: an in vivo-in vitro approach. Hexachlorocyclohexane 0-7 estrogen receptor 2 Homo sapiens 86-93 17537412-7 2007 Thus, gamma-HCH elicited subtle effects on female reproductive development likely mediated by ER-beta-mediated pathway(s), without a concurrent impairment of steroid hormone metabolism. Hexachlorocyclohexane 6-15 estrogen receptor 2 Homo sapiens 94-101 17537412-8 2007 Furthermore, to verify whether the endocrine interference of gamma-HCH is attributable to stimulation of ER-beta-mediated pathway(s), its effect has been evaluated in vitro on a cell line, LNCaP, expressing only functional ER-beta. Hexachlorocyclohexane 61-70 estrogen receptor 2 Homo sapiens 105-112 17537412-10 2007 Significantly, the contemporary addition of a pure anti-estrogen, the ER antagonist ICI 182,780, completely reversed gamma-HCH effects indicating an ER-beta-mediated action. Hexachlorocyclohexane 117-126 estrogen receptor 2 Homo sapiens 149-156 16838206-6 2006 Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). Hexachlorocyclohexane 12-15 microsomal glutathione S-transferase 1 Sus scrofa 92-95 16838206-6 2006 Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). Hexachlorocyclohexane 12-15 glutathione-disulfide reductase Sus scrofa 98-119 16838206-6 2006 Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). Hexachlorocyclohexane 12-15 glutathione-disulfide reductase Sus scrofa 121-123 16838206-6 2006 Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). Hexachlorocyclohexane 12-15 catalase Sus scrofa 196-204 16838206-6 2006 Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). Hexachlorocyclohexane 12-15 catalase Sus scrofa 206-209 16818664-8 2006 Rather, the activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is required for Lindane to disrupt the autophagic pathway. Hexachlorocyclohexane 138-145 mitogen-activated protein kinase 1 Homo sapiens 109-112 16127354-8 2005 An increase in SOD and catalase activities was observed in the 7-mg/kg/day dose of lindane. Hexachlorocyclohexane 83-90 catalase Rattus norvegicus 23-31 21783693-10 2006 Significant decline in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase along with increase in hydrogen peroxide generation and lipid peroxidation were observed in lindane treated animals. Hexachlorocyclohexane 211-218 catalase Rattus norvegicus 63-71 21783693-10 2006 Significant decline in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase along with increase in hydrogen peroxide generation and lipid peroxidation were observed in lindane treated animals. Hexachlorocyclohexane 211-218 glutathione-disulfide reductase Rattus norvegicus 97-118 16837770-5 2006 On the other hand, ovariectomy, administration of ICI182780, a specific estrogen antagonist, or administration of lindane, which is a widely used pesticide with anti-estrogenic effects, induced these adult male-specific CYP mRNAs in adult female SD rats. Hexachlorocyclohexane 114-121 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 220-223 16432761-3 2006 HCH induced oxidative stress in EAT cells which was characterized by glutathione depletion, lipid peroxidation (LPO), reactive oxygen species (ROS) production and inhibition of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Hexachlorocyclohexane 0-3 catalase Mus musculus 229-237 16432761-3 2006 HCH induced oxidative stress in EAT cells which was characterized by glutathione depletion, lipid peroxidation (LPO), reactive oxygen species (ROS) production and inhibition of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Hexachlorocyclohexane 0-3 catalase Mus musculus 239-242 16641539-14 2005 This suggests that while lindane most strongly induces CYP2B, it also upregulates a number of other drug metabolizing enzymes, such as CYP1A, CYP3A, and UDP-GT. Hexachlorocyclohexane 25-32 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 142-147 16537435-1 2006 Several major insecticides, including alpha-endosulfan, lindane, and fipronil, and the botanical picrotoxinin are noncompetitive antagonists (NCAs) for the GABA receptor. Hexachlorocyclohexane 56-63 GABA type A receptor-associated protein Homo sapiens 156-169 16156589-2 2005 Three laboratory strains selected by tetrachlorvinphos, lindane (gamma-HCH) and dimethoate, respectively, had significantly elevated CDNB- and DCNB-GST activities. Hexachlorocyclohexane 56-63 glutathione S-transferase Musca domestica 148-151 16156589-2 2005 Three laboratory strains selected by tetrachlorvinphos, lindane (gamma-HCH) and dimethoate, respectively, had significantly elevated CDNB- and DCNB-GST activities. Hexachlorocyclohexane 65-74 glutathione S-transferase Musca domestica 148-151 16156589-6 2005 GST-R was likely to be involved in gamma-HCH resistance in strain 17e, tetrachlorvinphos resistance in strain 39m2b, and dimethoate resistance in strain 49r2b. Hexachlorocyclohexane 35-44 glutathione S-transferase Musca domestica 0-3 16009145-4 2005 RESULTS: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Hexachlorocyclohexane 115-122 interleukin 2 Homo sapiens 15-19 15888667-2 2005 The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation. Hexachlorocyclohexane 104-111 mitogen-activated protein kinase 3 Homo sapiens 150-154 15888667-2 2005 The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation. Hexachlorocyclohexane 104-111 mitogen-activated protein kinase 3 Homo sapiens 235-241 16009145-4 2005 RESULTS: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Hexachlorocyclohexane 115-122 interleukin 4 Homo sapiens 21-25 16009145-4 2005 RESULTS: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Hexachlorocyclohexane 115-122 tumor necrosis factor Homo sapiens 31-40 16009145-4 2005 RESULTS: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Hexachlorocyclohexane 115-122 interferon gamma Homo sapiens 91-100 15025948-6 2004 In these conditions, the expression of TNF-alpha and IL-1alpha is enhanced, with maximal increases in their respective mRNA content and serum levels of the cytokines being elicited at 18 h after gamma-hexachlorocyclohexane treatment. Hexachlorocyclohexane 195-222 tumor necrosis factor Rattus norvegicus 39-48 15749814-0 2005 Lindane, a gap junction blocker, suppresses FSH and transforming growth factor beta1-induced connexin43 gap junction formation and steroidogenesis in rat granulosa cells. Hexachlorocyclohexane 0-7 transforming growth factor, beta 1 Rattus norvegicus 52-84 15749814-0 2005 Lindane, a gap junction blocker, suppresses FSH and transforming growth factor beta1-induced connexin43 gap junction formation and steroidogenesis in rat granulosa cells. Hexachlorocyclohexane 0-7 gap junction protein, alpha 1 Rattus norvegicus 93-103 15749814-3 2005 First, we investigated the effect of FSH and TGF beta1 as well as lindane (a general gap junction blocker) on the level of connexin43 (Cx43), the major gap junction constituent in granulosa cells, and on gap junction function. Hexachlorocyclohexane 66-73 gap junction protein, alpha 1 Rattus norvegicus 123-133 15749814-3 2005 First, we investigated the effect of FSH and TGF beta1 as well as lindane (a general gap junction blocker) on the level of connexin43 (Cx43), the major gap junction constituent in granulosa cells, and on gap junction function. Hexachlorocyclohexane 66-73 gap junction protein, alpha 1 Rattus norvegicus 135-139 15749814-4 2005 The second aim was to determine the effect of lindane on FSH and TGF beta1-stimulated progesterone production and the levels of two critical players, cytochrome P450 side-chain cleavage (P450scc) enzyme and steroidogenic acute regulatory (StAR) protein. Hexachlorocyclohexane 46-53 transforming growth factor, beta 1 Rattus norvegicus 65-74 15749814-6 2005 Immunoblotting analysis showed that FSH plus TGF beta1 dramatically increased the levels of phosphorylated Cx43 without significantly influencing the level of nonphosphorylated Cx43, and this stimulatory effect was completely suppressed by lindane. Hexachlorocyclohexane 240-247 transforming growth factor, beta 1 Rattus norvegicus 45-54 15749814-7 2005 Also, immunofluorescence analysis showed that Cx43 immuno-reactivity increased in the FSH plus TGF beta1-treated group and predominantly appeared in a punctate pattern at cell-cell contact sites, and lindane reduced such cell periphery immunostaining. Hexachlorocyclohexane 200-207 transforming growth factor, beta 1 Rattus norvegicus 95-104 15749814-9 2005 In addition, lindane suppressed the FSH and TGF beta1-stimulated increases in progesterone production and the levels of P450scc enzyme and StAR protein. Hexachlorocyclohexane 13-20 transforming growth factor, beta 1 Rattus norvegicus 44-53 15749814-9 2005 In addition, lindane suppressed the FSH and TGF beta1-stimulated increases in progesterone production and the levels of P450scc enzyme and StAR protein. Hexachlorocyclohexane 13-20 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 120-127 15749814-9 2005 In addition, lindane suppressed the FSH and TGF beta1-stimulated increases in progesterone production and the levels of P450scc enzyme and StAR protein. Hexachlorocyclohexane 13-20 steroidogenic acute regulatory protein Rattus norvegicus 139-143 15250540-2 2004 The present study tested the hypothesis that lindane and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibit gap junction communication in rat myometrial and liver WBr-F344 cells by the common mechanism of increasing phosphorylation of the gap junction protein connexin43. Hexachlorocyclohexane 45-52 gap junction protein, alpha 1 Rattus norvegicus 278-288 15250540-7 2004 Lindane increased immunostaining for phospho-connexin43 (S368) in WBr-F344 cells without altering the abundance, electrophoretic mobility or phosphorylation of connexin43 as detected in immunoblots. Hexachlorocyclohexane 0-7 gap junction protein, alpha 1 Rattus norvegicus 45-55 15749814-10 2005 This study demonstrates a clear temporal association between the Cx43 protein level/gap junction communication and progesterone production in rat ovarian granulosa cells in response to FSH and TGF beta1 as well as lindane. Hexachlorocyclohexane 214-221 gap junction protein, alpha 1 Rattus norvegicus 65-69 15025948-6 2004 In these conditions, the expression of TNF-alpha and IL-1alpha is enhanced, with maximal increases in their respective mRNA content and serum levels of the cytokines being elicited at 18 h after gamma-hexachlorocyclohexane treatment. Hexachlorocyclohexane 195-222 interleukin 1 alpha Rattus norvegicus 53-62 15025948-8 2004 gamma-Hexachlorocyclohexane-induced TNF-alpha levels in serum are suppressed by pretreatment with an antisense oligonucleotide (ASO TJU-2755; daily doses of 10 mg/kg for 2 days) targeting the primary transcript for the cytokine, whereas those of IL-1alpha are not modified. Hexachlorocyclohexane 0-27 tumor necrosis factor Rattus norvegicus 36-45 15025948-8 2004 gamma-Hexachlorocyclohexane-induced TNF-alpha levels in serum are suppressed by pretreatment with an antisense oligonucleotide (ASO TJU-2755; daily doses of 10 mg/kg for 2 days) targeting the primary transcript for the cytokine, whereas those of IL-1alpha are not modified. Hexachlorocyclohexane 0-27 interleukin 1 alpha Rattus norvegicus 246-255 15025948-9 2004 It is concluded that gamma-hexachlorocyclohexane-induced liver oxidative stress triggers the DNA binding activity of NF-kappaB, with the consequent increase in the expression of NF-kappaB-dependent genes for TNF-alpha and for IL-1alpha, factors that may mediate the hepatotoxicity of the insecticide. Hexachlorocyclohexane 21-48 tumor necrosis factor Rattus norvegicus 208-217 15025948-9 2004 It is concluded that gamma-hexachlorocyclohexane-induced liver oxidative stress triggers the DNA binding activity of NF-kappaB, with the consequent increase in the expression of NF-kappaB-dependent genes for TNF-alpha and for IL-1alpha, factors that may mediate the hepatotoxicity of the insecticide. Hexachlorocyclohexane 21-48 interleukin 1 alpha Rattus norvegicus 226-235 14688026-10 2004 Low dose lindane (10(-12)-10(-10) M) significantly elevated the percentage of MCF-7 cells staining positive for Bcl-2 and of PC-3 cells staining positive for Bax. Hexachlorocyclohexane 9-16 BCL2 apoptosis regulator Homo sapiens 112-117 14688026-10 2004 Low dose lindane (10(-12)-10(-10) M) significantly elevated the percentage of MCF-7 cells staining positive for Bcl-2 and of PC-3 cells staining positive for Bax. Hexachlorocyclohexane 9-16 BCL2 associated X, apoptosis regulator Homo sapiens 158-161 12919956-6 2003 Lindane potentiated cell killing by heat shock at 43 degrees C, whereas little or no cytotoxicity was observed at 37 degrees C. Nuclear translocation of heat shock protein 72 (HSP72) was interrupted by lindane, although its induction was not affected. Hexachlorocyclohexane 0-7 heat shock protein family A (Hsp70) member 1A Homo sapiens 153-174 15620088-5 2004 In addition, single and repeated-dose treatments of mice with lindane induced: (i) cytochrome P450 by 23 and 65%, respectively, (ii) cytochrome b5 by 49 and 131%, respectively, (iii) AHH activity by 64 and 50%, respectively. Hexachlorocyclohexane 62-69 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 183-186 15620088-7 2004 Moreover, single- and repeated-dose treatments of mice with lindane decreased the GSH levels by 40 and 54%, respectively, and induced GST activity by 25 and 41%, respectively. Hexachlorocyclohexane 60-67 hematopoietic prostaglandin D synthase Mus musculus 134-137 15194225-4 2004 By using gamma-hexachlorocyclohexane (HCH), known to induce gap junction endocytosis, we demonstrated that endocytosis increased Cx43/ZO-1 association within the cytoplasm of treated Sertoli cells. Hexachlorocyclohexane 9-36 gap junction protein alpha 1 Homo sapiens 129-133 15194225-4 2004 By using gamma-hexachlorocyclohexane (HCH), known to induce gap junction endocytosis, we demonstrated that endocytosis increased Cx43/ZO-1 association within the cytoplasm of treated Sertoli cells. Hexachlorocyclohexane 9-36 tight junction protein 1 Homo sapiens 134-138 15194225-4 2004 By using gamma-hexachlorocyclohexane (HCH), known to induce gap junction endocytosis, we demonstrated that endocytosis increased Cx43/ZO-1 association within the cytoplasm of treated Sertoli cells. Hexachlorocyclohexane 38-41 gap junction protein alpha 1 Homo sapiens 129-133 15194225-4 2004 By using gamma-hexachlorocyclohexane (HCH), known to induce gap junction endocytosis, we demonstrated that endocytosis increased Cx43/ZO-1 association within the cytoplasm of treated Sertoli cells. Hexachlorocyclohexane 38-41 tight junction protein 1 Homo sapiens 134-138 15194225-7 2004 The HCH induced Cx43 hyperphosphorylation was abolished by the ERK inhibitor PD98059 suggesting that this effect could be mediated through activation of the ERK pathway. Hexachlorocyclohexane 4-7 gap junction protein alpha 1 Homo sapiens 16-20 15194225-7 2004 The HCH induced Cx43 hyperphosphorylation was abolished by the ERK inhibitor PD98059 suggesting that this effect could be mediated through activation of the ERK pathway. Hexachlorocyclohexane 4-7 mitogen-activated protein kinase 1 Homo sapiens 63-66 15194225-7 2004 The HCH induced Cx43 hyperphosphorylation was abolished by the ERK inhibitor PD98059 suggesting that this effect could be mediated through activation of the ERK pathway. Hexachlorocyclohexane 4-7 mitogen-activated protein kinase 1 Homo sapiens 157-160 14667721-0 2004 Air-sea gas exchange of HCHs and PCBs and enantiomers of alpha-HCH in the Kattegat Sea region. Hexachlorocyclohexane 24-28 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 4-7 12919956-6 2003 Lindane potentiated cell killing by heat shock at 43 degrees C, whereas little or no cytotoxicity was observed at 37 degrees C. Nuclear translocation of heat shock protein 72 (HSP72) was interrupted by lindane, although its induction was not affected. Hexachlorocyclohexane 0-7 heat shock protein family A (Hsp70) member 1A Homo sapiens 176-181 12919956-6 2003 Lindane potentiated cell killing by heat shock at 43 degrees C, whereas little or no cytotoxicity was observed at 37 degrees C. Nuclear translocation of heat shock protein 72 (HSP72) was interrupted by lindane, although its induction was not affected. Hexachlorocyclohexane 202-209 heat shock protein family A (Hsp70) member 1A Homo sapiens 153-174 12919956-6 2003 Lindane potentiated cell killing by heat shock at 43 degrees C, whereas little or no cytotoxicity was observed at 37 degrees C. Nuclear translocation of heat shock protein 72 (HSP72) was interrupted by lindane, although its induction was not affected. Hexachlorocyclohexane 202-209 heat shock protein family A (Hsp70) member 1A Homo sapiens 176-181 12919956-7 2003 These results indicate that lindane exacerbates hyperthermic lethality via disrupted nuclear translocation of HSP72 protein. Hexachlorocyclohexane 28-35 heat shock protein family A (Hsp70) member 1A Homo sapiens 110-115 12807735-2 2003 Using the 42GPA9 Sertoli cell line, we recently reported that one widely used lipid-soluble pesticide, Lindane impairs gap junctional intercellular communication by promoting the intracellular localization of Connexin 43 (Cx43), a tumor suppressor. Hexachlorocyclohexane 103-110 gap junction protein, alpha 1 Mus musculus 209-220 12807735-2 2003 Using the 42GPA9 Sertoli cell line, we recently reported that one widely used lipid-soluble pesticide, Lindane impairs gap junctional intercellular communication by promoting the intracellular localization of Connexin 43 (Cx43), a tumor suppressor. Hexachlorocyclohexane 103-110 gap junction protein, alpha 1 Mus musculus 222-226 12807735-4 2003 Interestingly, evidence is provided that Lindane-induced Cx43 endocytosis did not stem on alteration of Cx43 partition in lipid rafts. Hexachlorocyclohexane 41-48 gap junction protein, alpha 1 Mus musculus 57-61 12807735-5 2003 Lindane induced concomitantly Cx43 phosphorylation and activation of extracellular signal-regulated kinases (ERK) but not of JNK and p38 mitogen- activated protein kinases. Hexachlorocyclohexane 0-7 gap junction protein, alpha 1 Mus musculus 30-34 12807735-5 2003 Lindane induced concomitantly Cx43 phosphorylation and activation of extracellular signal-regulated kinases (ERK) but not of JNK and p38 mitogen- activated protein kinases. Hexachlorocyclohexane 0-7 mitogen-activated protein kinase 1 Mus musculus 69-107 12807735-5 2003 Lindane induced concomitantly Cx43 phosphorylation and activation of extracellular signal-regulated kinases (ERK) but not of JNK and p38 mitogen- activated protein kinases. Hexachlorocyclohexane 0-7 mitogen-activated protein kinase 1 Mus musculus 109-112 12807735-6 2003 Inhibition of ERK pathway by PD98059, a MEK1-specific inhibitor, prevented Lindane-induced Cx43 phosphorylation, restored Cx43 membranous localization and gap junction coupling. Hexachlorocyclohexane 75-82 mitogen-activated protein kinase 1 Mus musculus 14-17 12807735-6 2003 Inhibition of ERK pathway by PD98059, a MEK1-specific inhibitor, prevented Lindane-induced Cx43 phosphorylation, restored Cx43 membranous localization and gap junction coupling. Hexachlorocyclohexane 75-82 mitogen-activated protein kinase kinase 1 Mus musculus 40-44 12807735-6 2003 Inhibition of ERK pathway by PD98059, a MEK1-specific inhibitor, prevented Lindane-induced Cx43 phosphorylation, restored Cx43 membranous localization and gap junction coupling. Hexachlorocyclohexane 75-82 gap junction protein, alpha 1 Mus musculus 91-95 12807735-6 2003 Inhibition of ERK pathway by PD98059, a MEK1-specific inhibitor, prevented Lindane-induced Cx43 phosphorylation, restored Cx43 membranous localization and gap junction coupling. Hexachlorocyclohexane 75-82 gap junction protein, alpha 1 Mus musculus 122-126 12807735-7 2003 Altogether, these findings provide the first evidence that Lindane-altered Cx43 endocytosis requires ERK activation. Hexachlorocyclohexane 59-66 gap junction protein, alpha 1 Mus musculus 75-79 12807735-7 2003 Altogether, these findings provide the first evidence that Lindane-altered Cx43 endocytosis requires ERK activation. Hexachlorocyclohexane 59-66 mitogen-activated protein kinase 1 Mus musculus 101-104 12807735-8 2003 Such inappropriate activation of the mitogenic MAPK pathway and inactivation of the tumor suppressor Cx43 by Lindane may participate in the promotion of neoplastic cell growth. Hexachlorocyclohexane 109-116 gap junction protein, alpha 1 Mus musculus 101-105 12937714-7 2003 Total HCH presented blood concentrations that were six times greater in Pil es (0.84 g/l versus 0.13 g/l). Hexachlorocyclohexane 6-9 serpin family A member 2 (gene/pseudogene) Homo sapiens 72-75 11917985-0 2002 Evaluating a model of the historical behavior of two hexachlorocyclohexanes in the Baltic Sea environment. Hexachlorocyclohexane 53-75 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 90-93 12849724-0 2003 Aromatase activity modulation by lindane and bisphenol-A in human placental JEG-3 and transfected kidney E293 cells. Hexachlorocyclohexane 33-40 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 0-9 12849724-3 2003 Since lindane and bisphenol-A (BPA) are two well-characterized endocrine disruptors that have been detected in animals and humans, it was important to learn whether they could affect aromatase activity and consequently estrogen biosynthesis. Hexachlorocyclohexane 6-13 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 183-192 12849724-10 2003 Therefore, lindane and BPA modulate aromatase activity suggesting an interaction with the cytochrome P-450 aromatase. Hexachlorocyclohexane 11-18 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 36-45 12849724-10 2003 Therefore, lindane and BPA modulate aromatase activity suggesting an interaction with the cytochrome P-450 aromatase. Hexachlorocyclohexane 11-18 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 107-116 14631868-5 2003 Concomitantly, the molecular activity of NADPH-cytochrome p450 reductase was enhanced by 90 and 69% by HCCH and T3, respectively. Hexachlorocyclohexane 103-107 cytochrome p450 oxidoreductase Rattus norvegicus 41-72 12364975-7 2002 In case of rats, a significant decline in the activity of catalase was recorded in response to HCH whereas a sharp augmentation in the enzyme activity was noticed in mice. Hexachlorocyclohexane 95-98 catalase Rattus norvegicus 58-66 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorocyclohexane 52-56 negative elongation factor complex member C/D Homo sapiens 80-83 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorocyclohexane 52-56 interleukin 2 Homo sapiens 103-107 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorocyclohexane 52-56 interferon gamma Homo sapiens 112-128 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorocyclohexane 52-56 interferon gamma Homo sapiens 130-139 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorocyclohexane 52-56 interleukin 4 Homo sapiens 176-180 11948501-9 2002 Furthermore, since CYP3A2 protein expression appears to be important for the effects of phenobarbital and the alpha-isomer of benzene hexachloride, mRNAs for IL-1 receptor type 1 (IL-1R1) and TNF-alpha receptor type 1 (TNFR1) whose ligands have roles not only in downregulating CYP3A2 expression but also in inducing antiproliferative effect or apoptosis in hepatocyte were examined. Hexachlorocyclohexane 126-146 cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus 19-25 11917986-0 2002 Mass budgets, pathways, and equilibrium states of two hexachlorocyclohexanes in the Baltic Sea environment. Hexachlorocyclohexane 54-76 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 91-94 11312652-7 2001 The selectivity order for 29 insecticides and convulsants as IC50 ratios for native/beta3 or alpha1beta3gamma2/beta3 was as follows: fipronil > lindane > 19 other insecticides including alpha-endosulfan and picrotoxinin > 4 trioxabicyclooctanes and dithianes (almost nonselective) > tetramethylenedisulfotetramine, 4-chlorophenylsilatrane, or alpha-thujone. Hexachlorocyclohexane 147-154 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 84-116 11601461-5 2001 The criteria for repeatability were met for all compounds except trifluralin, dimethoate, and lindane in bottled water and chlorpyrifos, dimethoate, and lindane in tap water. Hexachlorocyclohexane 153-160 nuclear RNA export factor 1 Homo sapiens 164-167 11811620-2 2001 In 10 day-old suckling pups exposed to lindane, there was a significant decrease in the activities of sucrase (29%), lactase (20%) and that of alkaline phosphatase (24%) compared to control. Hexachlorocyclohexane 39-46 lactase Rattus norvegicus 117-124 11808555-2 2002 The average of hexachlorocyclohexanes (HCHs; sum of isomers alpha-, beta-, gamma-, delta-) was nearly equal in the Bering Sea (mean concentration 412.7 pg/l) and in the Chukchi Sea (mean concentration 445.8 pg/l), which showed no obvious latitudinal difference of these two regions. Hexachlorocyclohexane 15-37 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 122-125 11808555-4 2002 The ratio of alpha:gamma HCH was 5.0 and 3.4 for the Bering and Chukchi sea, respectively, which indicated the different pesticide composition in these two regions. Hexachlorocyclohexane 19-28 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 72-75 11808555-6 2002 Heptachlor epoxide (in the Bering Sea) and heptachlor (in the Chukchi Sea) were main OCPs contaminants besides HCHs. Hexachlorocyclohexane 111-115 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 70-73 12645305-16 2002 Lindane decreased the membrane erythrocyte and cerebral cell concentration of phosphatidyl inositol PI, PIP and PIP2 in rats repetitively exposed to lindane for 3 or 6 months. Hexachlorocyclohexane 0-7 prolactin induced protein Rattus norvegicus 104-107 12645305-16 2002 Lindane decreased the membrane erythrocyte and cerebral cell concentration of phosphatidyl inositol PI, PIP and PIP2 in rats repetitively exposed to lindane for 3 or 6 months. Hexachlorocyclohexane 149-156 prolactin induced protein Rattus norvegicus 104-107 11684361-0 2001 Ovariectomy modulates the response of some cytochrome P450 isozymes to lindane in the rat. Hexachlorocyclohexane 71-78 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 43-58 11684361-2 2001 lindane, administered in corn oil by gavage, on cytochrome P450 (CYP) phenotype was investigated in the liver of ovariectomized (ovx), sham operated (sham-ope) and nonovariectomized (n/ovx) adult Wistar rats. Hexachlorocyclohexane 0-7 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 48-63 11684361-2 2001 lindane, administered in corn oil by gavage, on cytochrome P450 (CYP) phenotype was investigated in the liver of ovariectomized (ovx), sham operated (sham-ope) and nonovariectomized (n/ovx) adult Wistar rats. Hexachlorocyclohexane 0-7 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 65-68 11684361-13 2001 These results, overall, indicate that ovariectomy significantly affects, both qualitatively and quantitatively, CYP expression following induction by lindane and support the anti-estrogenic effect of lindane in rats. Hexachlorocyclohexane 150-157 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 112-115 11684361-13 2001 These results, overall, indicate that ovariectomy significantly affects, both qualitatively and quantitatively, CYP expression following induction by lindane and support the anti-estrogenic effect of lindane in rats. Hexachlorocyclohexane 200-207 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 112-115 11684361-14 2001 The pathophysiological and toxicological relevance of liver CYP induction by lindane and possibly other organochlorine xenobiotics in females with a lack or deficiency of estrogen supply remains to be investigated. Hexachlorocyclohexane 77-84 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 60-63 11532877-0 2001 Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells. Hexachlorocyclohexane 60-67 gap junction protein, alpha 1 Mus musculus 112-122 11532877-7 2001 After a 24 h lindane exposure, Cx43 and ZO-1 colocalized within the cytoplasm and no modification of non-phosphorylated and phosphorylated isoforms of Cx43 was observed. Hexachlorocyclohexane 13-20 gap junction protein, alpha 1 Mus musculus 31-35 11532877-7 2001 After a 24 h lindane exposure, Cx43 and ZO-1 colocalized within the cytoplasm and no modification of non-phosphorylated and phosphorylated isoforms of Cx43 was observed. Hexachlorocyclohexane 13-20 tight junction protein 1 Mus musculus 40-44 11279263-4 2001 Picrotoxin, PTZ and lindane stimulated BDNF production in the entorhinal cortex and also in the hippocampus of rats showing very severe convulsions. Hexachlorocyclohexane 20-27 brain-derived neurotrophic factor Rattus norvegicus 39-43