PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21467632-5	2011	2-O-Sulfate residues in heparin were essential for the binding of rGST-NKG2A and rGST-NKG2C.	2-o-sulfate	0-11	killer cell lectin like receptor C1	Homo sapiens	71-76
21467632-5	2011	2-O-Sulfate residues in heparin were essential for the binding of rGST-NKG2A and rGST-NKG2C.	2-o-sulfate	0-11	killer cell lectin like receptor C2	Homo sapiens	86-91
20554947-9	2010	The 2-O-sulfotransferase showed a preference for mono-2-O-sulfated substrates as compared with octasaccharides with no 2-O-sulfate group.	2-o-sulfate	54-65	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	4-24
9742689-4	1998	The C-2 epimerization from delta HexA(2-O-sulfate) (alpha 1-4)GlcN(2-N-,6-O-disulfate) to delta HexA(2-O-sulfate) (alpha 1-4)ManN(2-N-,6-O-disulfate) was also demonstrated to take place in vitro under very mild alkaline conditions.	2-o-sulfate	38-49	complement C2	Homo sapiens	4-7
16120610-7	2005	In contrast, high affinity interactions with PTN required decasaccharides with E units (GlcUAbeta1-3GalNAc(4, 6-O-disulfate)), B units (GlcUA(2-O-sulfate)beta1-3GalNAc(4-O-sulfate)), and/or their IdoUA-containing counterparts (iE and iB) in addition to D/iD units, although the biological significance of such strong interactions remains to be investigated.	2-o-sulfate	142-153	pleiotrophin	Sus scrofa	45-48
12058038-9	2002	However, a single 2-O-sulfate group in the absence of 6-O-sulfation gave higher affinity for FGF2.	2-o-sulfate	18-29	fibroblast growth factor 2	Homo sapiens	93-97
15528194-4	2005	Whereas the N-sulfate group of heparin was most important, the 2-O-sulfate and 6-O-sulfate groups also contributed to neuregulin-1 binding in these two assays.	2-o-sulfate	63-74	neuregulin 1	Homo sapiens	118-130
12626395-0	2003	The binding of human glial cell line-derived neurotrophic factor to heparin and heparan sulfate: importance of 2-O-sulfate groups and effect on its interaction with its receptor, GFRalpha1.	2-o-sulfate	111-122	glial cell derived neurotrophic factor	Homo sapiens	21-64
12626395-3	2003	The binding of GDNF to heparin is particularly dependent on the presence of 2-O-sulfate groups.	2-o-sulfate	76-87	glial cell derived neurotrophic factor	Homo sapiens	15-19
12626395-7	2003	Considered overall, these findings provide strong support for a hypothesis that the bioactivity of GDNF during prenatal development is essentially dependent on the binding of this growth factor to 2-O-sulfate-rich heparin-related glycosaminoglycan.	2-o-sulfate	197-208	glial cell derived neurotrophic factor	Homo sapiens	99-103
9742689-4	1998	The C-2 epimerization from delta HexA(2-O-sulfate) (alpha 1-4)GlcN(2-N-,6-O-disulfate) to delta HexA(2-O-sulfate) (alpha 1-4)ManN(2-N-,6-O-disulfate) was also demonstrated to take place in vitro under very mild alkaline conditions.	2-o-sulfate	101-112	complement C2	Homo sapiens	4-7
34916232-3	2021	Arylsulfatase K (ARSK) is a recently characterised lysosomal hydrolase involved in GAG degradation that removes the 2-O-sulfate group from 2-sulfoglucuronate.	2-o-sulfate	116-127	arylsulfatase family member K	Homo sapiens	0-15
9089410-0	1997	Importance of 2-O-sulfate groups of uronate residues in heparin for activation of FGF-1 and FGF-2.	2-o-sulfate	14-25	fibroblast growth factor 1	Mus musculus	82-87
9089410-0	1997	Importance of 2-O-sulfate groups of uronate residues in heparin for activation of FGF-1 and FGF-2.	2-o-sulfate	14-25	fibroblast growth factor 2	Mus musculus	92-97
9089410-5	1997	These results suggest that a high content of 2-O-sulfate groups in uronate residues of heparin is required for activation of both FGF-1 and FGF-2.	2-o-sulfate	45-56	fibroblast growth factor 1	Mus musculus	130-135
9089410-5	1997	These results suggest that a high content of 2-O-sulfate groups in uronate residues of heparin is required for activation of both FGF-1 and FGF-2.	2-o-sulfate	45-56	fibroblast growth factor 2	Mus musculus	140-145
8299226-17	1994	SLE IgG anti-HS antibodies recognize a sulfated uronic acid epitope containing 2-O-sulfate which is important in certain functions of HS, including antithrombin III binding.	2-o-sulfate	79-90	serpin family C member 1	Homo sapiens	148-164
34916232-3	2021	Arylsulfatase K (ARSK) is a recently characterised lysosomal hydrolase involved in GAG degradation that removes the 2-O-sulfate group from 2-sulfoglucuronate.	2-o-sulfate	116-127	arylsulfatase family member K	Homo sapiens	17-21
4019466-4	1985	Disaccharides prepared by cleavage of heparin and N-deacetylated chondroitin 6-sulfate with nitrous acid were used to demonstrate a new sulfatase that catalyzed the removal of the 2-O-sulfate substituents from GlcA but not IdoA residues.	2-o-sulfate	180-191	arylsulfatase family member H	Homo sapiens	136-145
28543100-9	2017	Moreover, administration of purified syndecan-1, HS, or engineered heparan compounds containing 2-O-sulfate groups rescued Sdc1-/- mice from AILI by potentiating Akt signaling and inhibiting GSK-3beta-mediated apoptosis in hepatocytes.	2-o-sulfate	96-107	syndecan 1	Mus musculus	123-127
28543100-9	2017	Moreover, administration of purified syndecan-1, HS, or engineered heparan compounds containing 2-O-sulfate groups rescued Sdc1-/- mice from AILI by potentiating Akt signaling and inhibiting GSK-3beta-mediated apoptosis in hepatocytes.	2-o-sulfate	96-107	thymoma viral proto-oncogene 1	Mus musculus	162-165
28543100-9	2017	Moreover, administration of purified syndecan-1, HS, or engineered heparan compounds containing 2-O-sulfate groups rescued Sdc1-/- mice from AILI by potentiating Akt signaling and inhibiting GSK-3beta-mediated apoptosis in hepatocytes.	2-o-sulfate	96-107	glycogen synthase kinase 3 beta	Mus musculus	191-200
28124818-0	2017	A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.	2-o-sulfate	33-44	serpin family D member 1	Homo sapiens	92-111
25931123-7	2015	Our results also showed that purified syndecan-1 ectodomain and heparan compounds containing 2-O-sulfate motifs inhibit S. aureus killing by antimicrobial factors secreted by degranulated neutrophils, but does not affect intracellular phagocytic killing by neutrophils.	2-o-sulfate	93-104	syndecan 1	Mus musculus	38-48
25931123-9	2015	Furthermore, we found that purified syndecan-1 ectodomain and heparan compounds containing 2-O-sulfate units potently and specifically inhibit S. aureus killing by synthetic CRAMP.	2-o-sulfate	91-102	syndecan 1	Mus musculus	36-46