PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 17602659-5 2007 Studies performed in model solutions helped to clarify the formation mechanism of these pigments that can result from the nucleophilic attack of the olefinic double bond of a hydroxycinnamic acid to the eletrophilic C-10 position of the anthocyanin-pyruvic acid adduct, followed by the loss of a formic acid molecule and decarboxylation. Coumaric Acids 175-195 homeobox C10 Homo sapiens 216-220 17635218-6 2007 In contrast to its negative influence on flavonoid biosynthesis and coincident with high expression in the periderm and tapetum, AtDOF4;2 positively influences the production of hydroxycinnamic acids in the hypocotyl and flower buds, implicating its possible importance for suberin and sporopollenin production. Coumaric Acids 178-199 Dof-type zinc finger domain-containing protein Arabidopsis thaliana 129-137 16500886-12 2006 Among the standard phenolics only resveratrol (24.1 %), hydroxybenzoic acid (19.3 %) and coumaric acid (2.3 %) had ACE inhibitory activity. Coumaric Acids 89-102 angiotensin-converting enzyme Oryctolagus cuniculus 115-118 17177789-5 2006 Here, we report the use of artificial zinc finger chimeras to specifically regulate the 4-coumarate:coenzyme-A ligase-1 (At4CL1) gene in A. thaliana. Coumaric Acids 88-99 4-coumarate:CoA ligase 1 Arabidopsis thaliana 121-127 16524605-0 2006 Modeling suberization with peroxidase-catalyzed polymerization of hydroxycinnamic acids: cross-coupling and dimerization reactions. Coumaric Acids 66-87 peroxidase N1 Solanum tuberosum 27-37 16524605-1 2006 An anionic potato peroxidase (EC 1.11.1.7, APP) thought to be involved in suberization after wounding was isolated from slices of Solanum tuberosum in order to elucidate the first steps of dehydrogenative polymerization between pairs of different hydroxycinnamic acids (FA, CafA, CA and SA) present in wound-healing plant tissues. Coumaric Acids 247-268 peroxidase N1 Solanum tuberosum 18-28 14769935-3 2004 The encoded enzyme, At4CL4, exhibits the rare property of efficiently activating sinapate, besides the usual 4CL substrates (4-coumarate, caffeate, and ferulate), indicating a distinct metabolic function. Coumaric Acids 125-136 4-coumarate:CoA ligase 2 Arabidopsis thaliana 22-25 15740983-10 2005 Thus, the increase in eNOS in response to red wine involves several polyphenolic compounds with a major contribution from trans-resveratrol and lesser contributions from cinnamic and hydroxycinnamic acids, cyanidin, and some phenolic acids. Coumaric Acids 183-204 nitric oxide synthase 3 Homo sapiens 22-26 12015158-3 2002 In this regard we investigated the putative antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H(2)O(2) and TNFalpha induced damage to human microvascular endothelial cells. Coumaric Acids 130-151 tumor necrosis factor Homo sapiens 173-181 14595847-5 2003 The erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities, plus glutathione (GSH) level, were all significantly higher in the 4-hydroxycinnamate- and HPP-supplemented groups than in the control group. Coumaric Acids 141-159 catalase Rattus norvegicus 47-55 14595847-5 2003 The erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities, plus glutathione (GSH) level, were all significantly higher in the 4-hydroxycinnamate- and HPP-supplemented groups than in the control group. Coumaric Acids 141-159 catalase Rattus norvegicus 57-60 14595847-6 2003 However, both 4-hydroxycinnamate and HPP supplementation significantly lowered the hepatic activities and mRNA expression of CAT and glutathione peroxidase (GSH-Px) compared to the control group. Coumaric Acids 14-32 catalase Rattus norvegicus 125-128 12481050-5 2002 Biochemical analysis of COMT-AS showed: (a) a strong decrease in Klason lignin content at the flowering stage, (b) a decrease in syringyl units, (c) a lower p-coumaric acid content, and (d) the occurrence of unusual 5-OH guaiacyl units. Coumaric Acids 159-172 caffeic acid 3-O-methyltransferase Zea mays 24-28 11430984-5 2001 Furthermore, a suberization-associated anionic peroxidase has been purified from suberizing potato tubers and subsequently shown to oxidize hydroxycinnamic acids (and their derivatives) in preference to monolignols, as well as yield an unique polymer in vitro. Coumaric Acids 140-161 peroxidase N1 Solanum tuberosum 47-57 11576429-0 2001 Identification of 4-coumarate:coenzyme A ligase (4CL) substrate recognition domains. Coumaric Acids 18-29 4-coumarate:CoA ligase 2 Arabidopsis thaliana 49-52 11576429-6 2001 While both enzymes convert 4-coumarate, only At4CL1 is also capable of converting ferulate. Coumaric Acids 27-38 4-coumarate:CoA ligase 1 Arabidopsis thaliana 45-51 10711794-0 1999 Interaction of hydroxycinnamic acid derivatives with the Cl3COO radical: a pulse radiolysis study. Coumaric Acids 15-35 adhesion G protein-coupled receptor L3 Homo sapiens 57-60 11697120-4 2001 Time-resolved resonance Raman (TR3) spectra of the radical from 4-hydroxycinnamate were measured using a probe laser wavelength of 600 nm, to be in resonance with the long wavelength absorption band of the radical. Coumaric Acids 64-82 nuclear receptor subfamily 4 group A member 1 Homo sapiens 31-34 2050114-1 1991 The parsley 4CL-1 gene encodes 4-coumarate:CoA ligase, a key enzyme of general phenylpropanoid metabolism. Coumaric Acids 31-42 4-coumarate--CoA ligase 1 Nicotiana tabacum 12-17 12228522-0 1995 Properties of a Maize Glutathione S-Transferase That Conjugates Coumaric Acid and Other Phenylpropanoids. Coumaric Acids 64-77 glutathione S-transferase Zea mays 22-47 8819324-7 1996 The relative abilities of recombinant 4CL1 and 4CL2 proteins to utilize 4-coumarate, ferulate, and caffeate as substrates were similar and comparable with that of 4CL in tobacco stem extracts. Coumaric Acids 72-83 4-coumarate--CoA ligase 2-like Nicotiana tabacum 38-41 12228382-1 1995 A pathogen elicitor-inducible soluble acyltransferase (tyramine hydroxycinnamoyltransferase [THT], EC 2.3.1), which catalyzes the transfer of hydroxycinnamic acids from hydroxycinnamoyl-coenzyme A (CoA) esters to tyramine in the formation of N-hydroxycinnamoyltyramine, was partially purified with a 380-fold enrichment and a 6% recovery from cell-suspension cultures of potato (Solanum tuberosum L. cv Datura). Coumaric Acids 142-163 tyramine N-feruloyltransferase 4/11-like Solanum tuberosum 55-91 8350679-4 1993 In the presence of tyrosine kinase inhibitor coumaric acid (0.2 approximately 2 microM), A431 cell growth was stimulated, rather than inhibited, by EGF in a dose-dependent manner. Coumaric Acids 45-58 epidermal growth factor Homo sapiens 148-151 8350679-6 1993 Furthermore, in the presence of coumaric acid (up to 0.5 microM), EGF-induced production of inositol phosphates in A431 cells was not obviously affected. Coumaric Acids 32-45 epidermal growth factor Homo sapiens 66-69 34062799-0 2021 Laccase and Tyrosinase Biosensors Used in the Determination of Hydroxycinnamic Acids. Coumaric Acids 63-84 tyrosinase Homo sapiens 12-22 1840921-1 1991 The 4CL-1 gene is one of two highly homologous parsley genes encoding 4-coumarate:coenzyme A ligase, a key enzyme of general phenylpropanoid metabolism. Coumaric Acids 70-81 4-coumarate--CoA ligase 1 Nicotiana tabacum 4-9 34600198-2 2022 5-O-caffeoylquinic acid (CQA) is one of the major hydroxycinnamic acid derivatives and it is the preferential substrate for polyphenol oxidase (PPO) in apple juices. Coumaric Acids 50-70 polyphenol oxidase, chloroplastic Malus domestica 124-142 34600198-2 2022 5-O-caffeoylquinic acid (CQA) is one of the major hydroxycinnamic acid derivatives and it is the preferential substrate for polyphenol oxidase (PPO) in apple juices. Coumaric Acids 50-70 polyphenol oxidase, chloroplastic Malus domestica 144-147 33770716-9 2021 Our results shown that the ectopic PAP1 expression led to significant accumulation of cyanidin-type anthocyanins, quercetin-type flavonols and hydroxycinnamic acids and their glycosylated derivatives. Coumaric Acids 143-164 phosphatidic acid phosphatase 1 Arabidopsis thaliana 35-39 33807529-2 2021 In this study, chitosan (CS) was functionalized with three kinds of hydroxycinnamic acids (p-coumaric acid, caffeic acid and ferulic acid) through the carbodiimide-mediated grafting method. Coumaric Acids 68-89 citrate synthase Homo sapiens 25-27 33807529-4 2021 For the first time, the functionalities of the different hydroxycinnamic acid-g-CS films were compared. Coumaric Acids 57-77 citrate synthase Homo sapiens 80-82 33807529-6 2021 Instrumental analyses confirmed hydroxycinnamic acids conjugated with CS through amide and ester bonds. Coumaric Acids 32-53 citrate synthase Homo sapiens 70-72 33807529-7 2021 The functionalization of CS film with hydroxycinnamic acids produced a more compact microstructure and higher UV light barrier ability, mechanical strength, water vapor barrier ability, thermal stability and antioxidant and antimicrobial activities. Coumaric Acids 38-59 citrate synthase Homo sapiens 25-27 33807529-8 2021 Among the different hydroxycinnamic acid-g-CS films, caffeic acid-g-CS film presented the strongest barrier, mechanical, antioxidant and antimicrobial properties. Coumaric Acids 20-40 citrate synthase Homo sapiens 43-45 33807529-8 2021 Among the different hydroxycinnamic acid-g-CS films, caffeic acid-g-CS film presented the strongest barrier, mechanical, antioxidant and antimicrobial properties. Coumaric Acids 20-40 citrate synthase Homo sapiens 68-70 34859906-3 2021 Here, we discovered a novel hydroxycinnamic acid named sinapic acid (SA) derived from fruits, vegetables, cereals, and oil crops as an effective anti-PC molecule. Coumaric Acids 28-48 acyl-CoA synthetase medium chain family member 3 Homo sapiens 69-71 34062799-5 2021 The following sections of this review will briefly describe some of the laccase (Lac) and tyrosinase (Tyr) biosensors used for determining the main hydroxycinnamic acids of interest in the food or cosmetics industry. Coumaric Acids 148-169 tyrosinase Homo sapiens 90-100 34062799-6 2021 Considering relevant studies in the field, the fact has been noticed that there is a greater number of studies on laccase-based biosensors as compared to those based on tyrosinase for the detection of hydroxycinnamic acids. Coumaric Acids 201-222 tyrosinase Homo sapiens 169-179 34981525-2 2022 Here we report for the first that, trans-ferulic acid (TFA) is a potent dietary bioactive molecule of hydroxycinnamic acid derivative for the activation of AMPK with a maximum increase in phosphorylation (2.71/2.67 +- 0.10; p < .001 vs. high glucose (HG) control) in hyperglycemia-induced human liver cells (HepG2) and rat skeletal muscle cells (L6), where HG suppresses the AMPK pathway. Coumaric Acids 102-122 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 156-160 35581065-7 2022 Treatment with both rhCOMP-Ang1 and coumaric acid increases proliferation, mineralization, and migration of cultured hPLFs via activation of the Ang1/Tie2 signaling axis at a greater rate than treatment with either of them alone. Coumaric Acids 36-49 angiopoietin 1 Rattus norvegicus 145-149 35581065-7 2022 Treatment with both rhCOMP-Ang1 and coumaric acid increases proliferation, mineralization, and migration of cultured hPLFs via activation of the Ang1/Tie2 signaling axis at a greater rate than treatment with either of them alone. Coumaric Acids 36-49 TEK receptor tyrosine kinase Homo sapiens 150-154 35581065-8 2022 Collectively, this study demonstrates that CA-ACS impregnated with rhCOMP-Ang1 enhances bone regeneration at therapeutic sites, and this enhancement is associated with a synergistic interaction between rhCOMP-Ang1-mediated angiogenesis and coumaric acid-related antioxidant responses. Coumaric Acids 240-253 angiopoietin 1 Rattus norvegicus 209-213 34981525-2 2022 Here we report for the first that, trans-ferulic acid (TFA) is a potent dietary bioactive molecule of hydroxycinnamic acid derivative for the activation of AMPK with a maximum increase in phosphorylation (2.71/2.67 +- 0.10; p < .001 vs. high glucose (HG) control) in hyperglycemia-induced human liver cells (HepG2) and rat skeletal muscle cells (L6), where HG suppresses the AMPK pathway. Coumaric Acids 102-122 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 375-379 34053981-2 2021 Here we demonstrate the chemoenzymatic syntheses of 4-coumaroyl- and hexanoyl-amino acids, using 4-coumarate: coenzyme A ligase from the model plant Arabidopsis thaliana (At4CL2). Coumaric Acids 97-108 4-coumarate:CoA ligase 2 Arabidopsis thaliana 171-177 24424641-2 1976 4.3.1.5) activity in potato tuber discs, and exogenous supplies of cinnamic acid and p-coumaric acid can inhibit the appearance of cinnamic acid 4-hydroxylase (CA4H, E.C. Coumaric Acids 87-100 trans-cinnamate 4-monooxygenase Solanum tuberosum 131-158 24424641-2 1976 4.3.1.5) activity in potato tuber discs, and exogenous supplies of cinnamic acid and p-coumaric acid can inhibit the appearance of cinnamic acid 4-hydroxylase (CA4H, E.C. Coumaric Acids 87-100 trans-cinnamate 4-monooxygenase Solanum tuberosum 160-164 33090159-3 2020 Correspondingly, the related enzymes, including phenylalanine ammonia-lyase (PAL), cinnamate-4-hydroxylase (C4H), and 4-coumarate:coenzyme A ligase (4CL), were activated. Coumaric Acids 118-129 phenylalanine ammonia-lyase Sesamum indicum 48-75 33379009-10 2021 The method was applied to evaluate 10 phenolic compounds, of wich p-coumaric acid showed the best inhibitory activity for AChE (40.14 +- 4.75% at 10 mg L-1); and quercetin for alpha-glu (46.53 +- 4.90% at 10 mg L-1). Coumaric Acids 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 33866633-7 2021 Moreover, glycosylation activity of UGT73C7 resulted in the redirection of phenylpropanoid metabolic flux to biosynthesis of hydroxycinnamic acids and coumarins. Coumaric Acids 125-146 UDP-glucosyl transferase 73C7 Arabidopsis thaliana 36-43 33343392-1 2020 Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic acids with an interesting array of biological activities; e.g., antioxidant, anti-inflammatory, antimicrobial and cytostatic. Coumaric Acids 73-94 structural maintenance of chromosomes 2 Homo sapiens 43-47 33106428-8 2020 Besides conferring tolerance to aromatic acids, ESBP6 overexpression was also shown to significantly improve the secretion in coumaric acid production strains. Coumaric Acids 126-139 Esbp6p Saccharomyces cerevisiae S288C 48-53 32428854-5 2020 The coumaric acid content was increased from 35.03 mug/mL to 307.66 mug/mL at lnR0 of 8.16. Coumaric Acids 4-17 thrombopoietin Mus musculus 55-57 32750608-0 2020 Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches. Coumaric Acids 0-13 tyrosinase Homo sapiens 29-39 32750608-3 2020 Accordingly, this paper reports the assessment of several coumaric acid derivatives as tyrosinase inhibitors and antimelanogenic agents in in vitro, in silico and ex vivo assays. Coumaric Acids 58-71 tyrosinase Homo sapiens 87-97 32428854-5 2020 The coumaric acid content was increased from 35.03 mug/mL to 307.66 mug/mL at lnR0 of 8.16. Coumaric Acids 4-17 thrombopoietin Mus musculus 72-74 31120744-0 2019 Hydroxamic Acid Derivatives of beta-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways. Coumaric Acids 46-66 AKT serine/threonine kinase 1 Homo sapiens 125-128 32625101-3 2020 In this study, we investigated whether coumaric acid- and caffeic acid-conjugated peptides might affect alpha-melanocyte stimulating hormone-induced melanin production, tyrosinase activity, and melanin synthesis-related gene expression in SK-MEL-2 human melanoma cells. Coumaric Acids 39-52 proopiomelanocortin Homo sapiens 104-140 32625101-3 2020 In this study, we investigated whether coumaric acid- and caffeic acid-conjugated peptides might affect alpha-melanocyte stimulating hormone-induced melanin production, tyrosinase activity, and melanin synthesis-related gene expression in SK-MEL-2 human melanoma cells. Coumaric Acids 39-52 tyrosinase Homo sapiens 169-179 32625101-5 2020 In addition, coumaric acid- and caffeic acid-conjugated peptides suppressed tyrosinase activity more than arbutin, a known tyrosinase inhibitor. Coumaric Acids 13-26 tyrosinase Homo sapiens 76-86 32625101-5 2020 In addition, coumaric acid- and caffeic acid-conjugated peptides suppressed tyrosinase activity more than arbutin, a known tyrosinase inhibitor. Coumaric Acids 13-26 tyrosinase Homo sapiens 123-133 31804581-8 2019 Enhanced levels of hydroxycinnamic acid amides, typical phytoalexins of potato, in StSERK3A/B-RNAi plants are accompanied by significantly decreased levels of flavonoids and steroidal glycoalkaloids. Coumaric Acids 19-46 BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like Solanum tuberosum 83-91 31382682-3 2019 p-Coumaric acid has the optimal structure to be a competitive inhibitor of tyrosinase that catalyzes key reactions in the melanin biosynthetic pathway. Coumaric Acids 2-15 tyrosinase Homo sapiens 75-85 32347378-2 2020 The excellent antifouling properties of WS2 decorated with AuNP-CT into a high conductivity network of CB results in high selectivity, sensitivity, and reproducibility for the simultaneous determination of hydroxycinnamic acid (hCN) structural analogs: caffeic (CF), sinapic (SP), and p-coumaric acids (CM). Coumaric Acids 206-226 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 228-231 31147155-8 2019 A statistical increase in the retention time of protocatechuic acid and decrease in the peak width of tyrosol, caffeic acid, and coumaric acid were noted when the gradient column was oriented to have the C18 dense region located near the detector. Coumaric Acids 129-142 Bardet-Biedl syndrome 9 Homo sapiens 204-207 30902306-4 2019 Gene expression levels of p-coumarate 3-hydroxylase, cinnamic acid 4-hydroxylase and caffeic acid O-methyltransferase were positively correlated with the content of ferulic and p-coumaric acids, respectively. Coumaric Acids 179-193 omet Triticum aestivum 98-117 31120744-0 2019 Hydroxamic Acid Derivatives of beta-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways. Coumaric Acids 46-66 mechanistic target of rapamycin kinase Homo sapiens 129-133 30738615-3 2019 5"-O-Caffeoylquinic acid (CQA) is the major hydroxycinnamic acid in apple and the preferential substrate of apple polyphenoloxidase (PPO). Coumaric Acids 44-64 polyphenol oxidase, chloroplastic Malus domestica 114-131 30738615-3 2019 5"-O-Caffeoylquinic acid (CQA) is the major hydroxycinnamic acid in apple and the preferential substrate of apple polyphenoloxidase (PPO). Coumaric Acids 44-64 polyphenol oxidase, chloroplastic Malus domestica 133-136 30987122-5 2019 Furthermore, the acquired results from the selectivity studies revealed a strong anti-interference capability of the F-GO/GCE in the presence of other hydroxycinnamic acids and ascorbic acid. Coumaric Acids 151-172 aminomethyltransferase Homo sapiens 117-125 29605770-0 2018 p-Coumaric acid mediated protection of H9c2 cells from Doxorubicin-induced cardiotoxicity: Involvement of augmented Nrf2 and autophagy. Coumaric Acids 2-15 NFE2 like bZIP transcription factor 2 Rattus norvegicus 116-120 30047165-8 2019 Downregulation of the osmosis regulatory gene, osr-1, might contribute to p-coumaric acids" effect on increased resistance to high osmolarity. Coumaric Acids 76-90 Uncharacterized protein Caenorhabditis elegans 47-52 30318120-0 2018 p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats. Coumaric Acids 2-15 insulin-like growth factor 1 Rattus norvegicus 117-145 30318120-3 2018 Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Coumaric Acids 219-232 insulin-like growth factor 1 Rattus norvegicus 14-42 30318120-3 2018 Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Coumaric Acids 219-232 insulin-like growth factor 1 Rattus norvegicus 144-172 30318120-4 2018 Via increasing both the serum level of insulin-like growth factor 1 and its expression, p-coumaric acid could promote cell proliferation in growth plate zones. Coumaric Acids 90-103 insulin-like growth factor 1 Rattus norvegicus 39-67 28830814-7 2017 p-Coumaric acid dose-dependently increased the total activity of fEPSP after high frequency stimulation and attenuated scopolamine-induced blockade of fEPSP in the hippocampal CA1 area. Coumaric Acids 2-15 carbonic anhydrase 1 Rattus norvegicus 176-179 28386931-7 2018 Indeed, functional studies demonstrated that AN2 is less able to induce anthocyanins than AN1, but nevertheless it has a strong ability to induce accumulation of hydroxycinnamic acid derivatives. Coumaric Acids 162-182 AN2 Solanum tuberosum 45-48 29202545-0 2017 MMP9 Gene Expression Variation by Ingesting Tart Cherry and P-Coumaric Acid During Remyelination in the Cuprizone Mouse Model. Coumaric Acids 62-75 matrix metallopeptidase 9 Mus musculus 0-4 29202545-8 2017 Bioinformatics analysis displayed p-coumaric acid has potent inhibitory effect on MMP9 gene expression (Pa=0.818) with estimated DeltaG (kcal/mol) -8.10. Coumaric Acids 36-49 matrix metallopeptidase 9 Mus musculus 82-86 27490527-7 2016 Furthermore, coumaric acid treatment decreased the expression of main transcriptional factors such as CCAAT/enhancer binding protein-alpha (C/EBP-alpha) and peroxisome proliferator-activated receptor gamma-2 (PPAR-gamma2). Coumaric Acids 13-26 peroxisome proliferator activated receptor gamma Mus musculus 157-207 28482376-0 2017 Fragmentation characteristics of hydroxycinnamic acids in ESI-MSn by density functional theory. Coumaric Acids 33-54 moesin Homo sapiens 62-65 28482376-1 2017 This work aims to analyze the electrospray ionization multistage mass spectrometry (ESI-MSn ) fragmentation characteristics of hydroxycinnamic acids (HCAs) in negative ion mode. Coumaric Acids 127-148 moesin Homo sapiens 88-91 28482376-1 2017 This work aims to analyze the electrospray ionization multistage mass spectrometry (ESI-MSn ) fragmentation characteristics of hydroxycinnamic acids (HCAs) in negative ion mode. Coumaric Acids 150-154 moesin Homo sapiens 88-91 28146307-9 2017 An increase in hydroxycinnamic acid derivatives and a decrease in the hydroxycinnamyl aldehydes and alcohols in ccr1 lines, supports a shift of flux from lignin synthesis to other secondary metabolites and phenylpropanoid derivatives. Coumaric Acids 15-35 cinnamoyl coa reductase 1 Arabidopsis thaliana 112-116 28364699-4 2017 A standard of a hydroxycinnamic acid (HCA) derivative, L-chicoric acid (L-CA) - a di-acylated caffeoyltartaric acid ester found in a number of plant families - was used. Coumaric Acids 16-36 protein tyrosine phosphatase receptor type C Homo sapiens 55-70 28364699-4 2017 A standard of a hydroxycinnamic acid (HCA) derivative, L-chicoric acid (L-CA) - a di-acylated caffeoyltartaric acid ester found in a number of plant families - was used. Coumaric Acids 16-36 protein tyrosine phosphatase receptor type C Homo sapiens 72-76 28364699-4 2017 A standard of a hydroxycinnamic acid (HCA) derivative, L-chicoric acid (L-CA) - a di-acylated caffeoyltartaric acid ester found in a number of plant families - was used. Coumaric Acids 38-41 protein tyrosine phosphatase receptor type C Homo sapiens 55-70 28364699-4 2017 A standard of a hydroxycinnamic acid (HCA) derivative, L-chicoric acid (L-CA) - a di-acylated caffeoyltartaric acid ester found in a number of plant families - was used. Coumaric Acids 38-41 protein tyrosine phosphatase receptor type C Homo sapiens 72-76 28195469-5 2017 Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system. Coumaric Acids 105-118 UDP glucuronosyltransferase 1 family, polypeptide A7C Rattus norvegicus 14-17 28195469-5 2017 Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system. Coumaric Acids 105-118 UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus 22-25 27291250-0 2017 Hydroxy Cinnamic Acid Derivatives as Partial PPARgamma Agonists: In silico Studies, Synthesis and Biological Characterization Against Chronic Myeloid Leukemia Cell Line (K562). Coumaric Acids 0-21 peroxisome proliferator activated receptor gamma Homo sapiens 45-54 27291250-3 2017 OBJECTIVE: In this study we have rationally modified the structure of existing p-coumaric acid and ferulic acid, which would selectively activate PPARgamma and exert their anti-proliferative effect at lower dose as compared to natural phytoconstituents. Coumaric Acids 81-94 peroxisome proliferator activated receptor gamma Homo sapiens 146-155 27490527-7 2016 Furthermore, coumaric acid treatment decreased the expression of main transcriptional factors such as CCAAT/enhancer binding protein-alpha (C/EBP-alpha) and peroxisome proliferator-activated receptor gamma-2 (PPAR-gamma2). Coumaric Acids 13-26 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 102-138 27490527-7 2016 Furthermore, coumaric acid treatment decreased the expression of main transcriptional factors such as CCAAT/enhancer binding protein-alpha (C/EBP-alpha) and peroxisome proliferator-activated receptor gamma-2 (PPAR-gamma2). Coumaric Acids 13-26 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 140-151 27155966-5 2016 Using western blot to determine the effect of these samples on Abeta-induced activation of pERK1/2, p38, and JNK MAPKs, results revealed that both VOO and Hc acids inhibited the activation of pERK1/2 and p-p38 MAPK, but not JNK. Coumaric Acids 155-163 mitogen-activated protein kinase 14 Homo sapiens 100-103 27155966-5 2016 Using western blot to determine the effect of these samples on Abeta-induced activation of pERK1/2, p38, and JNK MAPKs, results revealed that both VOO and Hc acids inhibited the activation of pERK1/2 and p-p38 MAPK, but not JNK. Coumaric Acids 155-163 mitogen-activated protein kinase 8 Homo sapiens 109-112 27155966-5 2016 Using western blot to determine the effect of these samples on Abeta-induced activation of pERK1/2, p38, and JNK MAPKs, results revealed that both VOO and Hc acids inhibited the activation of pERK1/2 and p-p38 MAPK, but not JNK. Coumaric Acids 155-163 mitogen-activated protein kinase 14 Homo sapiens 206-209 27155966-5 2016 Using western blot to determine the effect of these samples on Abeta-induced activation of pERK1/2, p38, and JNK MAPKs, results revealed that both VOO and Hc acids inhibited the activation of pERK1/2 and p-p38 MAPK, but not JNK. Coumaric Acids 155-163 mitogen-activated protein kinase 8 Homo sapiens 224-227 27490527-7 2016 Furthermore, coumaric acid treatment decreased the expression of main transcriptional factors such as CCAAT/enhancer binding protein-alpha (C/EBP-alpha) and peroxisome proliferator-activated receptor gamma-2 (PPAR-gamma2). Coumaric Acids 13-26 peroxisome proliferator activated receptor gamma Mus musculus 209-220 27069498-6 2016 In adipose tissues, hydroxycinnamic acid derivatives inhibit macrophage infiltration and nuclear factor kappaB (NF-kappaB) activation in obese animals. Coumaric Acids 20-40 nuclear factor kappa B subunit 1 Homo sapiens 104-110 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 C-C motif chemokine ligand 2 Homo sapiens 177-182 27069498-6 2016 In adipose tissues, hydroxycinnamic acid derivatives inhibit macrophage infiltration and nuclear factor kappaB (NF-kappaB) activation in obese animals. Coumaric Acids 20-40 nuclear factor kappa B subunit 1 Homo sapiens 112-121 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 tumor necrosis factor Homo sapiens 101-128 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 serpin family E member 1 Homo sapiens 189-227 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 serpin family E member 1 Homo sapiens 229-234 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 tumor necrosis factor Homo sapiens 130-138 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 C-C motif chemokine ligand 2 Homo sapiens 141-175 26833384-6 2016 In addition, a net loss of sinapic acid upon UGT84A9 suppression may point to a feedback regulation of HCA biosynthesis. Coumaric Acids 103-106 UDP-glycosyltransferase 84A2-like Brassica napus 45-52 26049410-5 2015 A significant decrease in MDA, an increase in NRF1 levels, and increase in SOD activity were observed in the groups which received coumaric acid and methylprednisolone when compared to the corresponding untreated group (p < 0.05). Coumaric Acids 131-144 nuclear respiratory factor 1 Rattus norvegicus 46-50 26002085-0 2015 Hydroxycinnamic acids and UV-B depletion: Profiling and biosynthetic gene expression in flesh and peel of wild-type and hp-1. Coumaric Acids 0-21 DNA damage-binding protein 1 Solanum lycopersicum 120-124 25943038-10 2015 Nuclear respiratory factor 1 level and superoxide dismutase activity of the ischemia + coumaric acid group were significantly higher than in the ischemia group. Coumaric Acids 87-100 nuclear respiratory factor 1 Rattus norvegicus 0-28 25943038-12 2015 In immunohistochemical staining, hypoxia-inducible factor-1alpha and NF-kappa B immunopositive neurons were significantly decreased in the ischemia + coumaric acid group compared with that in the ischemia group. Coumaric Acids 150-163 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 33-64 26428924-6 2015 There was approximately 2.5 times more hrpA and hrpZ mRNA in PtoDC3000 that was grown in minimal media (MM) supplemented with 10 -M of ortho-coumaric acid than in PtoDC3000 grown in MM alone. Coumaric Acids 141-154 ATP-dependent RNA helicase HrpA Pseudomonas syringae pv. tomato str. DC3000 39-43 26132857-9 2015 This article summarizes most studied subclasses of polyphenols including flavonoids, hydroxycinnamic acids, hydroxybenzoic acids and lignans with pancreatic lipase inhibitory effects. Coumaric Acids 85-106 pancreatic lipase Homo sapiens 146-163 26048696-0 2015 P-coumaric acid regulates exon 12 splicing of the ATP7B gene by modulating hnRNP A1 protein expressions. Coumaric Acids 2-15 ATPase copper transporting beta Homo sapiens 50-55 26048696-0 2015 P-coumaric acid regulates exon 12 splicing of the ATP7B gene by modulating hnRNP A1 protein expressions. Coumaric Acids 2-15 heterogeneous nuclear ribonucleoprotein A1 Homo sapiens 75-83 25852989-8 2015 The overexpression of PAD1 and FDC1 resulted also in increased activity with the hydroxycinnamic acids ferulic acid, p-coumaric acid and caffeinic acid. Coumaric Acids 81-102 phenylacrylic acid decarboxylase PAD1 Saccharomyces cerevisiae S288C 22-26 25954129-0 2015 p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts. Coumaric Acids 2-15 stratifin Homo sapiens 50-59 25954129-0 2015 p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts. Coumaric Acids 2-15 matrix metallopeptidase 1 Homo sapiens 104-130 25852989-8 2015 The overexpression of PAD1 and FDC1 resulted also in increased activity with the hydroxycinnamic acids ferulic acid, p-coumaric acid and caffeinic acid. Coumaric Acids 81-102 putative phenylacrylic acid decarboxylase FDC1 Saccharomyces cerevisiae S288C 31-35 25459650-4 2014 Therefore, it can be established that due to the hydroxycinnamic acid content (caffeic, chlorogenic, feluric and p-coumaric acids), fruit, vegetables and beverages contribute to endothelial protection (attenuates oxidative stress, improved nitric oxide bioavailability and decreased E-selectin, ICAM-1 and VCAM-1 expression, among others). Coumaric Acids 49-69 selectin E Homo sapiens 283-293 25459650-4 2014 Therefore, it can be established that due to the hydroxycinnamic acid content (caffeic, chlorogenic, feluric and p-coumaric acids), fruit, vegetables and beverages contribute to endothelial protection (attenuates oxidative stress, improved nitric oxide bioavailability and decreased E-selectin, ICAM-1 and VCAM-1 expression, among others). Coumaric Acids 49-69 intercellular adhesion molecule 1 Homo sapiens 295-301 25459650-4 2014 Therefore, it can be established that due to the hydroxycinnamic acid content (caffeic, chlorogenic, feluric and p-coumaric acids), fruit, vegetables and beverages contribute to endothelial protection (attenuates oxidative stress, improved nitric oxide bioavailability and decreased E-selectin, ICAM-1 and VCAM-1 expression, among others). Coumaric Acids 49-69 vascular cell adhesion molecule 1 Homo sapiens 306-312 24964141-2 2014 This hydroxycinnamic acid derivate is a known activator of the redox-active Nrf2 signalling pathway in mammalian cells. Coumaric Acids 5-25 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 21538853-3 2011 METHODS AND RESULTS: We assessed the potential roles of organic anion transporters (OATs) and ATP-binding cassette (ABC) transporters in the renal uptake and efflux of hydroxycinnamic acid conjugates. Coumaric Acids 168-188 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 116-119 23355380-7 2013 The main polyphenols found in the propolis extract, artepillin C, coumaric acid, and kaempferide, promoted GLUT4 translocation in L6 myotubes. Coumaric Acids 66-79 solute carrier family 2 member 4 Rattus norvegicus 107-112 22407769-5 2012 By activity guided purification, three compounds of BACE1 inhibitors p-coumaric acid, gallic acid and ursolic acid were isolated from Corni fructus EtOAc fraction. Coumaric Acids 71-84 beta-secretase 1 Homo sapiens 52-57 22275284-1 2012 Since propolis and phenolic compounds, such as cinnamic and coumaric acids, have several biological properties, their immunomodulatory effect on cytokine production (IL-1beta, IL-6 and IL-10) was investigated. Coumaric Acids 60-74 interleukin 6 Mus musculus 176-180 22275284-1 2012 Since propolis and phenolic compounds, such as cinnamic and coumaric acids, have several biological properties, their immunomodulatory effect on cytokine production (IL-1beta, IL-6 and IL-10) was investigated. Coumaric Acids 60-74 interleukin 10 Mus musculus 185-190 22275284-4 2012 In LPS-challenge protocols, inhibitory concentrations of cinnamic and coumaric acids after LPS incubation prevented efficiently its effects on IL-6 production, whereas propolis inhibited LPS effects both before and after its addition. Coumaric Acids 70-84 interleukin 6 Mus musculus 143-147 22434333-0 2012 Characterization of hydroxycinnamic acid derivatives binding to bovine serum albumin. Coumaric Acids 20-40 albumin Homo sapiens 71-84 21981320-3 2011 As a consequence of the oxygen addition, the concentrations of hydroxycinnamic acid derivatives and flavan-3-ols decreased (above all t-GRP and (+)-catechin), leading to color stabilization, but also the concentrations of several volatile compounds with a great importance for quality aroma decreased. Coumaric Acids 63-83 gastrin releasing peptide Homo sapiens 136-139 21816585-4 2011 Coumaric acid and caffeic acid is able to quench the fluorescence of GSH/TGA-CdTe QDs, and the fluorescence intensity is linearly proportional to the concentration of quenchers. Coumaric Acids 0-13 T-box transcription factor 1 Homo sapiens 73-76 21816585-6 2011 The fluorescence recovery was due to the interaction of BSA with coumaric acid and caffeic acid, leading to the freeing of the GSH/TGA-CdTe QDs. Coumaric Acids 65-78 T-box transcription factor 1 Homo sapiens 131-134 24551237-7 2014 Similarly, hydroxycinnamic acids and derivatives (chlorogenic, cinnamic, and ferulic acids) combined with leucine/HMB increased FAO (300-1300%, p<0.01), AMPK activity (50-150%, p<0.01), and Sirt1 activity (~70%, p<0.001). Coumaric Acids 11-32 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 156-160 24551237-7 2014 Similarly, hydroxycinnamic acids and derivatives (chlorogenic, cinnamic, and ferulic acids) combined with leucine/HMB increased FAO (300-1300%, p<0.01), AMPK activity (50-150%, p<0.01), and Sirt1 activity (~70%, p<0.001). Coumaric Acids 11-32 sirtuin 1 Homo sapiens 196-201 24551237-9 2014 Thus, the six-carbon ring structure bound to a carboxylic group seems to be a necessary element for leucine/HMB synergy with other stilbenes and hydroxycinnamic acids to stimulate AMPK/Sirt1 dependent FAO; these effects occur at concentrations that produce no independent effects and are readily achievable via oral administration. Coumaric Acids 145-166 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 180-184 24551237-9 2014 Thus, the six-carbon ring structure bound to a carboxylic group seems to be a necessary element for leucine/HMB synergy with other stilbenes and hydroxycinnamic acids to stimulate AMPK/Sirt1 dependent FAO; these effects occur at concentrations that produce no independent effects and are readily achievable via oral administration. Coumaric Acids 145-166 sirtuin 1 Homo sapiens 185-190 24038617-2 2013 Hydroxycinnamic acids are highly sulfated in vivo, and sulfotransferases (SULTs), in particular SULT1A1, play a major role in their metabolism. Coumaric Acids 0-21 sulfotransferase family 1A member 1 Homo sapiens 96-103 23810795-5 2013 p-Coumaric acid suppressed adipogenesis by attenuating the expression of C/EBPalpha, PPARgamma, and SREBP-1c during the late phase of MDI-induced differentiation. Coumaric Acids 2-15 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 73-83 23810795-5 2013 p-Coumaric acid suppressed adipogenesis by attenuating the expression of C/EBPalpha, PPARgamma, and SREBP-1c during the late phase of MDI-induced differentiation. Coumaric Acids 2-15 peroxisome proliferator activated receptor gamma Mus musculus 85-94 23810795-5 2013 p-Coumaric acid suppressed adipogenesis by attenuating the expression of C/EBPalpha, PPARgamma, and SREBP-1c during the late phase of MDI-induced differentiation. Coumaric Acids 2-15 sterol regulatory element binding transcription factor 1 Mus musculus 100-108 23508643-7 2013 We hypothesize that BAHD candidate genes similar to the recently described Oryza sativa p-coumarate monolignol transferase (OsPMT) gene (PMT sub-clade) are principally responsible for the bound para-coumaric acid (pCA), and that other BAHD candidates (non-PMT sub-clade) are responsible for bound ferulic acid (FA). Coumaric Acids 199-212 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase-like Brachypodium distachyon 126-129 23508643-7 2013 We hypothesize that BAHD candidate genes similar to the recently described Oryza sativa p-coumarate monolignol transferase (OsPMT) gene (PMT sub-clade) are principally responsible for the bound para-coumaric acid (pCA), and that other BAHD candidates (non-PMT sub-clade) are responsible for bound ferulic acid (FA). Coumaric Acids 199-212 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase-like Brachypodium distachyon 137-140 23305921-2 2013 Here, various hydroxycinnamic acid (HCA) derivatives were further conjugated with phenylalanyl hydroxamic acid and prolyl hydroxamic acid (HCA-Phe-NHOH and HCA-Pro-NHOH) to study the structure and activity relationship as both antioxidants and tyrosinase inhibitors. Coumaric Acids 14-34 tyrosinase Mus musculus 244-254 23305921-2 2013 Here, various hydroxycinnamic acid (HCA) derivatives were further conjugated with phenylalanyl hydroxamic acid and prolyl hydroxamic acid (HCA-Phe-NHOH and HCA-Pro-NHOH) to study the structure and activity relationship as both antioxidants and tyrosinase inhibitors. Coumaric Acids 36-39 tyrosinase Mus musculus 244-254 22658537-2 2012 Hydroxycinnamic acid or analogs of natural products are important for potent inhibitory and selectivity against MMPs, and the solvent effect in the S1" pocket can affect the hydrophobic interactions and hydrogen bonds between MMPIs and MMPS, making MMPIs exhibit certain selectivity for a specific MMP isoenzyme. Coumaric Acids 0-20 matrix metallopeptidase 2 Homo sapiens 112-116 22658537-2 2012 Hydroxycinnamic acid or analogs of natural products are important for potent inhibitory and selectivity against MMPs, and the solvent effect in the S1" pocket can affect the hydrophobic interactions and hydrogen bonds between MMPIs and MMPS, making MMPIs exhibit certain selectivity for a specific MMP isoenzyme. Coumaric Acids 0-20 matrix metallopeptidase 2 Homo sapiens 236-240 22658537-2 2012 Hydroxycinnamic acid or analogs of natural products are important for potent inhibitory and selectivity against MMPs, and the solvent effect in the S1" pocket can affect the hydrophobic interactions and hydrogen bonds between MMPIs and MMPS, making MMPIs exhibit certain selectivity for a specific MMP isoenzyme. Coumaric Acids 0-20 matrix metallopeptidase 2 Homo sapiens 112-115 21538853-4 2011 Uptake studies using OAT1 (SLC22A6)-, OAT2 (SLC22A7)-, and OAT3 (SLC22A8)-expressing 293H embryonic kidney cells showed that OAT1 and OAT3, but not OAT2, accepted hydroxycinnamic acid conjugates as substrates. Coumaric Acids 163-183 solute carrier family 22 member 6 Homo sapiens 125-129 21538853-4 2011 Uptake studies using OAT1 (SLC22A6)-, OAT2 (SLC22A7)-, and OAT3 (SLC22A8)-expressing 293H embryonic kidney cells showed that OAT1 and OAT3, but not OAT2, accepted hydroxycinnamic acid conjugates as substrates. Coumaric Acids 163-183 solute carrier family 22 member 8 Homo sapiens 134-138 21538853-7 2011 On the other hand, hydroxycinnamic acid conjugates are not substrates for the ABC transporters, multidrug resistance protein 2 (MRP2/ABCC2) or breast cancer resistance protein (BCRP/ABCG2), demonstrated by the inability to alter ATPase activity. Coumaric Acids 19-39 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 182-187 21538853-9 2011 CONCLUSION: Concerted action of OAT1, OAT3, and OAT4 is involved in the elimination of hydroxycinnamic acid conjugates into urine, whereas MRP2 and breast cancer resistance protein are not involved in the disposition of these conjugates. Coumaric Acids 87-107 solute carrier family 22 member 6 Homo sapiens 32-36 21538853-9 2011 CONCLUSION: Concerted action of OAT1, OAT3, and OAT4 is involved in the elimination of hydroxycinnamic acid conjugates into urine, whereas MRP2 and breast cancer resistance protein are not involved in the disposition of these conjugates. Coumaric Acids 87-107 solute carrier family 22 member 8 Homo sapiens 38-42 21538853-9 2011 CONCLUSION: Concerted action of OAT1, OAT3, and OAT4 is involved in the elimination of hydroxycinnamic acid conjugates into urine, whereas MRP2 and breast cancer resistance protein are not involved in the disposition of these conjugates. Coumaric Acids 87-107 solute carrier family 22 member 11 Homo sapiens 48-52 19136666-4 2009 Here, we show that many phenolic acids, including those from the hydroxybenzoic and hydroxycinnamic acid classes, can bind and activate GPR109A (HM74a/PUMA-G), the receptor for the antidyslipidemic agent nicotinic acid. Coumaric Acids 84-104 hydroxycarboxylic acid receptor 2 Mus musculus 136-143 20077437-0 2010 p-coumaric acid not only inhibits human tyrosinase activity in vitro but also melanogenesis in cells exposed to UVB. Coumaric Acids 2-15 tyrosinase Homo sapiens 40-50 21393854-1 2011 4-Coumarate:CoA ligase 2 (4CL2) from Arabidopsis thaliana catalyzes the ATP-dependent formation of the 4-coumaroyl-CoA thioester through the formation of 4-coumarate-AMP. Coumaric Acids 0-11 4-coumarate:CoA ligase 2 Arabidopsis thaliana 26-30 18563436-6 2008 For UGT84A3, our data tentatively suggest an impact on cell wall-associated 4-coumarate. Coumaric Acids 76-87 UDP-Glycosyltransferase superfamily protein Arabidopsis thaliana 4-11 19013780-0 2009 The effects of hydroxycinnamic acid derivatives on adiponectin secretion. Coumaric Acids 15-35 adiponectin, C1Q and collagen domain containing Mus musculus 51-62 18071845-4 2008 The peroxidase sources differed both in the rate of H2O2-dependent hydroxycinnamate oxidation and in the order of affinity for the phenolic substrates. Coumaric Acids 67-83 peroxidase Glycine max 4-14 17766451-2 2007 The gene responsible was identified as PAD1, previously associated with the decarboxylation of the aromatic carboxylic acids cinnamic acid, ferulic acid, and coumaric acid to styrene, 4-vinylguaiacol, and 4-vinylphenol, respectively. Coumaric Acids 158-171 phenylacrylic acid decarboxylase PAD1 Saccharomyces cerevisiae S288C 39-43 18544081-6 2008 The compound (p-coumaric acid) inhibited alpha-MSH-stimulated cellular melanogenesis more effectively than arbutin or other structurally similar compounds including 3-(4-hydroxyphenyl) propionic acid, cinnamic acid and caffeic acid. Coumaric Acids 16-29 pro-opiomelanocortin-alpha Mus musculus 41-50 18502765-6 2008 In contrast to the known mammalian and plant enzymes, which exclusively methylate the meta-hydroxyl position of aromatic di- and trihydroxy systems, Syn-OMT also methylates the para-position of hydroxycinnamic acids like 5-hydroxyferulic and 3,4,5-trihydroxycinnamic acid, resulting in the formation of novel compounds. Coumaric Acids 194-215 synemin Homo sapiens 149-152