PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 17786331-0 2007 Inhibition of lymphocyte function associated antigen 1 by LFA878 induces apoptosis in multiple myeloma cells and is associated with downregulation of the focal adhesion kinase/phosphatidylinositol 3 kinase/Akt pathway. LFA 878 58-64 integrin subunit alpha L Homo sapiens 14-54 15304496-7 2004 Moreover, we demonstrate that the novel lovastatin-derived LFA-1 inhibitor LFA878 exhibits potent anti-inflammatory effects in carrageenan-induced rat paw edema. LFA 878 75-81 integrin subunit alpha L Rattus norvegicus 59-64 1659860-5 1991 In addition, the interaction of CD16 and AB8.28 induces calcium mobilization and increases granule secretion. LFA 878 41-44 Fc gamma receptor IIIa Homo sapiens 32-36 17786331-0 2007 Inhibition of lymphocyte function associated antigen 1 by LFA878 induces apoptosis in multiple myeloma cells and is associated with downregulation of the focal adhesion kinase/phosphatidylinositol 3 kinase/Akt pathway. LFA 878 58-64 AKT serine/threonine kinase 1 Homo sapiens 206-209 17786331-5 2007 The LFA-1 inhibitor LFA878 induces apoptosis in all four cell lines as revealed by annexin V staining and caspase 3 cleavage. LFA 878 20-26 integrin subunit alpha L Homo sapiens 4-9 17786331-5 2007 The LFA-1 inhibitor LFA878 induces apoptosis in all four cell lines as revealed by annexin V staining and caspase 3 cleavage. LFA 878 20-26 annexin A5 Homo sapiens 83-92 17786331-5 2007 The LFA-1 inhibitor LFA878 induces apoptosis in all four cell lines as revealed by annexin V staining and caspase 3 cleavage. LFA 878 20-26 caspase 3 Homo sapiens 106-115 17786331-8 2007 Western blots demonstrate downregulation of FAK, PI3-K, and Akt upon LFA878 treatment. LFA 878 69-75 protein tyrosine kinase 2 Homo sapiens 44-47 17786331-8 2007 Western blots demonstrate downregulation of FAK, PI3-K, and Akt upon LFA878 treatment. LFA 878 69-75 AKT serine/threonine kinase 1 Homo sapiens 60-63