PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 20188155-4 2010 While [Glu(2)]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. barbituric acid 144-155 thyrotropin releasing hormone Mus musculus 14-17 20188155-4 2010 While [Glu(2)]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. barbituric acid 144-155 thyrotropin releasing hormone Mus musculus 66-69 20188155-4 2010 While [Glu(2)]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. barbituric acid 144-155 thyrotropin releasing hormone Mus musculus 66-69 20053485-0 2010 Synthesis of highly functionalized barbituric acids and study of their interactions with p-glycoprotein and Mg2+--potential candidates for multi drug resistance modulation. barbituric acid 35-51 ATP binding cassette subfamily B member 1 Homo sapiens 89-103 20053485-0 2010 Synthesis of highly functionalized barbituric acids and study of their interactions with p-glycoprotein and Mg2+--potential candidates for multi drug resistance modulation. barbituric acid 35-51 mucin 7, secreted Homo sapiens 108-111 20053485-1 2010 A number of barbituric acids with appropriate substituent at C-5 position were synthesized and investigated for their interactions with p-gp and Mg(2+). barbituric acid 12-28 phosphoglycolate phosphatase Homo sapiens 136-140 18262506-10 2008 Our results are consistent with the hypothesis that Mpdz"s effects on CNS hyperexcitability, including alcohol and barbiturate withdrawal, involve MPDZ interaction with 5-HT2C and/or GABAB receptors. barbituric acid 115-126 multiple PDZ domain crumbs cell polarity complex component Mus musculus 52-56 18752947-0 2008 New PPARgamma ligands based on barbituric acid: virtual screening, synthesis and receptor binding studies. barbituric acid 31-46 peroxisome proliferator activated receptor gamma Mus musculus 4-13 18752947-1 2008 A new series of PPARgamma ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. barbituric acid 43-58 peroxisome proliferator activated receptor gamma Mus musculus 16-25 18752947-1 2008 A new series of PPARgamma ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. barbituric acid 60-62 peroxisome proliferator activated receptor gamma Mus musculus 16-25 18396900-7 2008 Zymography revealed an efficient blocking of enzyme activity of purified MMP-2 and MMP-9 and of MMP-containing cell supernatants (HT-1080), (A-673) using the PEGylated barbiturate 5. barbituric acid 168-179 matrix metallopeptidase 2 Homo sapiens 73-78 18396900-9 2008 Therefore, this new barbiturate-based MMP-probe has a high affinity and specificity toward MMP-2 and -9 and is thus a promising candidate for sensitive MMP detection in vivo. barbituric acid 20-31 matrix metallopeptidase 2 Homo sapiens 91-103 19022458-4 2009 The presence of the barbituric acid in subphase change the hydrophilicity of 2PDI-TAZ due to the hydrogen bonding between melamine and barbituric acid, which has been revealed by the pi-A isotherms and the FT-IR spectra. barbituric acid 20-35 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 82-85 19022458-4 2009 The presence of the barbituric acid in subphase change the hydrophilicity of 2PDI-TAZ due to the hydrogen bonding between melamine and barbituric acid, which has been revealed by the pi-A isotherms and the FT-IR spectra. barbituric acid 135-150 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 82-85 18580350-0 2008 Combined therapeutic hypothermia and barbiturate coma reduces interleukin-6 in the cerebrospinal fluid after aneurysmal subarachnoid hemorrhage. barbituric acid 37-48 interleukin 6 Homo sapiens 62-75 18343108-0 2008 Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors. barbituric acid 13-24 methionyl aminopeptidase 1 Homo sapiens 31-58 18343108-1 2008 The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. barbituric acid 32-43 methionyl aminopeptidase 1 Homo sapiens 92-119 15780611-0 2005 Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. barbituric acid 7-23 matrix metallopeptidase 13 Homo sapiens 44-50 17997313-1 2008 The aim of this study was to explore the effects of barbiturate coma on cerebral tissue oxygen tension and cerebrovascular pressure reactivity (PRx), as an index of cerebral autoregulation in severe head injury patients. barbituric acid 52-63 periaxin Homo sapiens 144-147 17368021-2 2007 These novel heterocyclic inhibitors of a zinc metalloprotease were designed using a pharmacophore model that we previously described while developing hydantoin and pyrimidinetrione (barbiturate) inhibitors of TACE. barbituric acid 164-180 ADAM metallopeptidase domain 17 Homo sapiens 209-213 17368021-2 2007 These novel heterocyclic inhibitors of a zinc metalloprotease were designed using a pharmacophore model that we previously described while developing hydantoin and pyrimidinetrione (barbiturate) inhibitors of TACE. barbituric acid 182-193 ADAM metallopeptidase domain 17 Homo sapiens 209-213 17935984-1 2007 Explorations in the pyrimidinetrione series of MMP-13 inhibitors led to the discovery of a series of spiro-fused compounds that are potent and selective inhibitors of MMP-13. barbituric acid 20-36 matrix metallopeptidase 13 Rattus norvegicus 47-53 17935984-1 2007 Explorations in the pyrimidinetrione series of MMP-13 inhibitors led to the discovery of a series of spiro-fused compounds that are potent and selective inhibitors of MMP-13. barbituric acid 20-36 matrix metallopeptidase 13 Rattus norvegicus 167-173 17188861-5 2007 The preceding paper described a novel series of potent and TACE-selective hydantoins and we previously described pyrimidinetrione (barbiturate) inhibitors of TACE, both of which contain the same P1" group as IK682. barbituric acid 113-129 ADAM metallopeptidase domain 17 Homo sapiens 158-162 17188861-5 2007 The preceding paper described a novel series of potent and TACE-selective hydantoins and we previously described pyrimidinetrione (barbiturate) inhibitors of TACE, both of which contain the same P1" group as IK682. barbituric acid 131-142 ADAM metallopeptidase domain 17 Homo sapiens 158-162 15780611-2 2005 Incorporation of a biaryl ether moiety at the C-5 position of the pyrimidinetrione ring resulted in a dramatic enhancement of MMP-13 potency. barbituric acid 66-82 matrix metallopeptidase 13 Homo sapiens 126-132 15780611-0 2005 Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. barbituric acid 7-23 matrix metallopeptidase 14 Homo sapiens 82-88 15780611-1 2005 Through the use of computational modeling, a series of pyrimidinetrione-based inhibitors of MMP-13 was designed based on a lead inhibitor identified through file screening. barbituric acid 55-71 matrix metallopeptidase 13 Homo sapiens 92-98 15263067-3 2004 In this study, we investigated barbiturate-mediated effects on the regulation of the transcription factor activator protein 1 (AP-1) in primary T lymphocytes. barbituric acid 31-42 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 106-125 15644873-7 2005 The barbiturate, pentobarbital and the dissociative anaesthetic, ketamine, used at clinical EC(50) were also shown to inhibit nAChR-induced increases in [Ca(2+)](i) by approximately 40%. barbituric acid 4-15 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 126-131 15263067-10 2004 In conclusion, our results contribute to the explanation of a clinically manifested immune suppression in barbiturate-treated patients and support the idea of a MAP kinase-independent regulation of AP-1 by PKC and calcium in human T cells. barbituric acid 106-117 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 198-202 15263067-3 2004 In this study, we investigated barbiturate-mediated effects on the regulation of the transcription factor activator protein 1 (AP-1) in primary T lymphocytes. barbituric acid 31-42 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 127-131 12920159-8 2003 In contrast, only the livers of the barbiturate-treated rats expressed CYP2B1 proteins or specific catalytic activity (androstenedione 16beta-hydroxylase). barbituric acid 36-47 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 71-77 15288804-0 2004 Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors. barbituric acid 76-87 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 31-38 15288804-0 2004 Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors. barbituric acid 76-87 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 43-49 15135080-7 2004 The barbiturate phenobarbital and the environmental toxicant 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are among the well characterized inducers for the CYP 2B and 3A enzymes and selected conjugation enzymes. barbituric acid 4-15 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 162-165 15835150-6 2004 Polarized UV-vis absorption study also revealed that the 2Por-TAZ molecules formed linear supramolecular networks on pure water and barbituric acid subphase with porphyrin flat planes facing toward the compression direction. barbituric acid 132-147 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 62-65 15835150-7 2004 The binding of barbituric acid with 2Por-TAZ molecules was observed from the expansion of the Langmuir monolayer film. barbituric acid 15-30 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 41-44 12951105-1 2003 Interactions between N-methylacetamide (NMA) and N-methylated derivatives of uracil, isocyanurate and barbituric acid have been studied using ab initio methods at the local MP2/6-31G** level of theory. barbituric acid 102-117 tryptase pseudogene 1 Homo sapiens 173-176 14742677-8 2004 Thus, our results demonstrate a novel mechanism of direct inhibition of the calcineurin/calmodulin complex that may explain some of the known immunosuppressive effects associated with barbiturate treatment. barbituric acid 184-195 calmodulin 1 Homo sapiens 88-98 12820244-3 2003 The barbiturate-induced sleeping time prolonged by CCl(4) administration to mice was signi fi cantly reduced after AvEE treatment proving the protective effect of the extract on microsomal drug-metabolizing enzymes.AvEE and ISOC administered to rats 48 h, 24 h and 2 h before, and 6 h after CCl(4) intoxication caused a signi fi cant decrease in the CCl(4)-induced elevation of hepatic enzymes activity in serum, i.e. sorbitol dehydrogenase (SDH), glutamate oxaloacetate and glutamate pyruvate transaminases (GOT, GPT). barbituric acid 4-15 sorbitol dehydrogenase Rattus norvegicus 418-440 12883408-15 2003 CONCLUSION: Thiopental-mediated inhibition of NF-kappaB activation is due to the suppression of IkappaB kinase activity and depends at least in part on the thio-group of the barbiturate molecule. barbituric acid 174-185 nuclear factor kappa B subunit 1 Homo sapiens 46-55 12837975-1 2003 Newborn male and female rats were treated with therapeutic-like levels of phenobarbital to determine whether early exposure to the barbiturate permanently alters (i.e., imprints) mechanisms regulating induction of constituent CYP (cytochrome P-450) isoforms. barbituric acid 131-142 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 231-247 12820244-3 2003 The barbiturate-induced sleeping time prolonged by CCl(4) administration to mice was signi fi cantly reduced after AvEE treatment proving the protective effect of the extract on microsomal drug-metabolizing enzymes.AvEE and ISOC administered to rats 48 h, 24 h and 2 h before, and 6 h after CCl(4) intoxication caused a signi fi cant decrease in the CCl(4)-induced elevation of hepatic enzymes activity in serum, i.e. sorbitol dehydrogenase (SDH), glutamate oxaloacetate and glutamate pyruvate transaminases (GOT, GPT). barbituric acid 4-15 sorbitol dehydrogenase Rattus norvegicus 442-445 12820244-3 2003 The barbiturate-induced sleeping time prolonged by CCl(4) administration to mice was signi fi cantly reduced after AvEE treatment proving the protective effect of the extract on microsomal drug-metabolizing enzymes.AvEE and ISOC administered to rats 48 h, 24 h and 2 h before, and 6 h after CCl(4) intoxication caused a signi fi cant decrease in the CCl(4)-induced elevation of hepatic enzymes activity in serum, i.e. sorbitol dehydrogenase (SDH), glutamate oxaloacetate and glutamate pyruvate transaminases (GOT, GPT). barbituric acid 4-15 glutamic--pyruvic transaminase Rattus norvegicus 514-517 12509155-1 2003 A conformational study on Barbituric (BA) and Thiobarbituric (TBA) acids was performed at ab initio MP2/6-31G** level on the neutral, protonated, mono- and di-anionic forms. barbituric acid 26-36 tryptase pseudogene 1 Homo sapiens 100-103 12390507-9 2002 As a result, traces of iron salts are capable of catalyzing the conversion of large amounts of BA into ALX. barbituric acid 95-97 hematopoietic SH2 domain containing Homo sapiens 103-106 12414112-5 2002 To further characterize GABA(A) receptor alterations, GABA-gated chloride influx modulated by the above barbiturate and neurosteroid was determined, finding that E(max) values were increased 60% and 42%, respectively. barbituric acid 104-115 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 24-40 11955521-8 2002 We conclude that the beta1 subunit M1 segment proline affects the linkage between GABA binding and channel gating and is critical for barbiturate enhancement. barbituric acid 134-145 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 21-26 11841808-7 2002 Phenobarbital-related MRP2 induction in primary rat hepatocytes was associated with some phenotypic effects of the barbiturate, such as prolonged cell survival and inhibition of cell proliferation. barbituric acid 115-126 ATP binding cassette subfamily C member 2 Rattus norvegicus 22-26 10789876-8 2000 CONCLUSION: In early stages of DAT, a barbiturate challenge may unmask abnormalities in brain electrical activity not seen at baseline. barbituric acid 38-49 solute carrier family 6 member 3 Homo sapiens 31-34 11113513-7 2000 Pharmacological properties of GABA(A) receptor at ED12 showed that positive allosteric modulation effects of the steroid 3alpha-hydroxy-5alpha-pregnan-20-one and the barbiturate pentobarbital sodium were enhanced by the treatment. barbituric acid 166-177 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 30-46 10997728-0 2000 Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. barbituric acid 97-108 5-hydroxytryptamine receptor 3A Homo sapiens 18-24 10869407-3 2000 Some of the cytochrome P450s (CYP), i. e., CYP2A1, 2A2, 2C6, 3A1, and 3A2, exhibit the typical transient response in which isoform levels (mRNA, protein, and/or specific catalytic activity) rise precipitously at the time of phenobarbital administration and rapidly decline to preinduction levels after withdrawal of the barbiturate. barbituric acid 320-331 cytochrome P450, family 2, subfamily a, polypeptide 1 Rattus norvegicus 43-49 10869407-5 2000 Only one of these isoforms, female predominant (M:F, approximately 1:2) CYP2C7, exhibited a barbiturate-induced delayed, but persistent approximately 30 to 50% overexpression from puberty through adulthood. barbituric acid 92-103 cytochrome P450, family 2, subfamily c, polypeptide 7 Rattus norvegicus 72-78 11557128-6 2001 2-Acetylaminofluorene also induces MRP2; in addition, expression of this transporter in liver cells is increased in response to various drugs, such as the barbiturate phenobarbital, the chemopreventive agent, oltipraz and the anticancer drug, cisplatin. barbituric acid 155-166 ATP binding cassette subfamily C member 2 Rattus norvegicus 35-39 11256950-1 2001 The constitutive androstane receptor (CAR) activates the expression of a reporter gene attached to the phenobarbital-response element (PBRE) of the cytochrome P450 2B1 (CYP2B1) gene in response to the barbiturate phenobarbital and the plant product picrotoxin. barbituric acid 201-212 nuclear receptor subfamily 1 group I member 3 Homo sapiens 4-36 11256950-1 2001 The constitutive androstane receptor (CAR) activates the expression of a reporter gene attached to the phenobarbital-response element (PBRE) of the cytochrome P450 2B1 (CYP2B1) gene in response to the barbiturate phenobarbital and the plant product picrotoxin. barbituric acid 201-212 nuclear receptor subfamily 1 group I member 3 Homo sapiens 38-41 11323161-3 2001 Similar to the rat mrp2 gene, human mrp2 is inducible by the chemical carcinogen 2-AAF, the chemotherapeutic drug cisplatin and the barbiturate phenobarbital, as demonstrated in Northern and Western Blots. barbituric acid 132-143 ATP binding cassette subfamily C member 2 Rattus norvegicus 19-23 11323161-3 2001 Similar to the rat mrp2 gene, human mrp2 is inducible by the chemical carcinogen 2-AAF, the chemotherapeutic drug cisplatin and the barbiturate phenobarbital, as demonstrated in Northern and Western Blots. barbituric acid 132-143 ATP binding cassette subfamily C member 2 Homo sapiens 36-40 11374610-4 2001 Paradoxically, GluR2 null mutant (-/-) mice are more sensitive to barbiturate-induced loss of the righting reflex (LORR) compared with wild-type (+/+) littermates. barbituric acid 66-77 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 15-20 11093784-1 2000 The barbiturate phenobarbital induces the transcription of cytochromes P450 (CYPs) 2B through the constitutive androstane receptor (CAR; NR1I3). barbituric acid 4-15 nuclear receptor subfamily 1 group I member 3 Homo sapiens 98-130 11093784-1 2000 The barbiturate phenobarbital induces the transcription of cytochromes P450 (CYPs) 2B through the constitutive androstane receptor (CAR; NR1I3). barbituric acid 4-15 nuclear receptor subfamily 1 group I member 3 Homo sapiens 132-135 11093784-1 2000 The barbiturate phenobarbital induces the transcription of cytochromes P450 (CYPs) 2B through the constitutive androstane receptor (CAR; NR1I3). barbituric acid 4-15 nuclear receptor subfamily 1 group I member 3 Homo sapiens 137-142 9952066-4 1999 The aims were to investigate if under clinical conditions, the barbiturate thiopental reduces important detoxification of glutamate, resulting in lower CSF glutamine, alanine and lactate levels as opposed to patients receiving midazolam. barbituric acid 63-74 colony stimulating factor 2 Homo sapiens 152-155 11113306-8 2000 Finally, the mechanism of hippocampal corticotropin-releasing hormone induction required neuronal stimulation and was abolished by barbiturate administration. barbituric acid 131-142 corticotropin releasing hormone Rattus norvegicus 38-69 10994593-5 2000 In barbiturate-anesthetized male rats electrical stimulation of XIIn produced a significant increase in Fos-positive neurons in the dorsal paratrigeminal nucleus (dPa5) and laminae I-II of caudal subnucleus caudalis (Vc) and upper cervical dorsal horn. barbituric acid 3-14 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 104-107 10551584-10 1999 CONCLUSIONS: The GluR2 null mutant mice were more sensitive to pentobarbital anesthesia despite a reduced sensitivity of GluR2-deficient AMPA receptors to barbiturate blockade. barbituric acid 155-166 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 17-22 10513989-4 1999 Based on these results, a structure-activity relationship of ligand binding to OPRTase was formulated using uracil, barbituric acid, and orotic acid as reference compounds. barbituric acid 116-131 uridine monophosphate synthetase Homo sapiens 79-86 10051524-1 1999 Barbiturate sensitivity was imparted to the human rho1 homooligomeric gamma-aminobutyric acid (GABA) receptor channel by mutation of a tryptophan residue at position 328 (Trp328), which is located within the third transmembrane domain. barbituric acid 0-11 GABA type A receptor-associated protein Homo sapiens 70-109 9422818-16 1997 The barbiturate also produced a substantial enhancement of the glycine-evoked currents, Imax and EC50 values being 71 +/- 2% and 845 +/- 66 microM and 51 +/- 10% and 757 +/- 30 microM for homomeric alpha 1 and heteromeric alpha 1 beta glycine receptors respectively. barbituric acid 4-15 adrenoceptor alpha 1D Homo sapiens 198-205 9422818-16 1997 The barbiturate also produced a substantial enhancement of the glycine-evoked currents, Imax and EC50 values being 71 +/- 2% and 845 +/- 66 microM and 51 +/- 10% and 757 +/- 30 microM for homomeric alpha 1 and heteromeric alpha 1 beta glycine receptors respectively. barbituric acid 4-15 adrenoceptor alpha 1D Homo sapiens 222-229 9436821-8 1997 The potentiating effect of thiopental was observed only when the barbiturate was administered during the first 2 h of the 24-h incubation period of cultured VSMCs with IL-1beta. barbituric acid 65-76 interleukin 1 beta Homo sapiens 168-176 9436821-10 1997 This barbiturate also significantly augmented the hyporeactivity to phenylephrine in carotid arteries exposed to IL-1beta, an effect that was abolished by N(G)-nitro-L-arginine. barbituric acid 5-16 interleukin 1 beta Homo sapiens 113-121 9134969-0 1997 Barbiturate-induced expression of neuronal nitric oxide synthase in the rat cerebellum. barbituric acid 0-11 nitric oxide synthase 1 Homo sapiens 34-64 9288409-0 1997 Biological determinants of P300: the effects of a barbiturate on latency and amplitude. barbituric acid 50-61 E1A binding protein p300 Homo sapiens 27-31 8930209-3 1996 However, early exposure to the barbiturate permanently alters (i.e., imprints) the inductive responsiveness of CYP2B1 and 2B2 to subsequent phenobarbital challenge in adulthood. barbituric acid 31-42 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 111-125 8952470-0 1996 Barbiturate inhibition of GLUT-1 mediated hexose transport in human erythrocytes exhibits substrate dependence for equilibrium exchange but not unidirectional sugar flux. barbituric acid 0-11 solute carrier family 2 member 1 Homo sapiens 26-32 7893187-1 1994 This paper presents a study of the action of phenobarbital (anticonvulsant barbituric acid with pK1 = 7.3 and pK2 = 11.8) on the short-circuit current and on the transepithelial conductance of the frog isolated skin. barbituric acid 75-90 prokineticin 1 Homo sapiens 96-99 8872994-2 1996 In this study, the effects of anesthesia on the modulation of the GABAA receptor complex by ethanol, a benzodiazepine, and a barbiturate were determined. barbituric acid 125-136 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 66-71 8643092-2 1996 In this regard, we examined the interactions of gender, adult age, and barbiturate dose on the course of phenobarbital induction of hepatic CYP2B1 and CYP2B2. barbituric acid 71-82 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 140-146 8643092-2 1996 In this regard, we examined the interactions of gender, adult age, and barbiturate dose on the course of phenobarbital induction of hepatic CYP2B1 and CYP2B2. barbituric acid 71-82 cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus 151-157 8643092-12 1996 In contrast, the same low dose of barbiturate inducing an equal percent increase in CYP2B2 mRNA did result in an expression of protein. barbituric acid 34-45 cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus 84-90 8088363-2 1994 Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital with the receptor was reduced. barbituric acid 118-129 glutamate receptor, ionotropic, AMPA 2 S homeolog Xenopus laevis 53-58 8088363-3 1994 This evidence demonstrates that the GluR2 subunit alters the structure of AMPA receptors in such a way as to facilitate any interaction with this barbiturate. barbituric acid 146-157 glutamate receptor, ionotropic, AMPA 2 S homeolog Xenopus laevis 36-41 8500825-3 1993 After the blockade of ovulation with barbiturate, the activity increases significantly in the whole follicle and also in the thecal layers till third day of ovulation and afterward it declines on 5th day, suggesting that rise in catalase activity may exert a protective function against lytic actions of peroxide which is known to be produced in the ovary during several metabolic and steroidogenic events. barbituric acid 37-48 catalase Rattus norvegicus 229-237 8477751-9 1993 Similarly, hepatocytes from phenobarbital-treated rats preserved the contents of barbiturate-inducible CYP2B1/2 and CYP3A proteins best when cultured on CMF/COL. barbituric acid 81-92 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 103-109 8477751-9 1993 Similarly, hepatocytes from phenobarbital-treated rats preserved the contents of barbiturate-inducible CYP2B1/2 and CYP3A proteins best when cultured on CMF/COL. barbituric acid 81-92 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 116-121 8485467-1 1993 Previous studies showed that anaesthesia with the barbiturate Thiopental induces an increase in membrane fluidity and a decrease in acetylcholinesterase activity in syncytiotrophoblast plasma membranes (SPM) obtained from placentas after Cesarean section. barbituric acid 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 8332263-1 1993 Immunocytochemistry was used to assess the distribution of neurons within the spinal trigeminal nucleus that expressed the protein product of the proto-oncogene c-fos after thermal stimulation of the cornea in barbiturate-anesthetized rats. barbituric acid 210-221 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 146-166 2389654-5 1990 The barbiturate increased the amplitudes of subcortical and early cortical components (N18, N20, P22, P25), whose latencies, however, were not significantly modified. barbituric acid 4-15 calcineurin like EF-hand protein 1 Homo sapiens 97-100 19215492-8 1991 Plasma levels of beta-endorphin-like immunoreactivity and estimated beta-endorphin with combined hypoxia and barbiturate anesthesia were also higher than those with barbiturate anesthesia. barbituric acid 109-120 proopiomelanocortin Homo sapiens 68-82 19215492-9 1991 The latter pattern was reversed in the nucleus tractus solitarii, in which beta-endorphin-like immunoreactivity and estimated beta-endorphin levels were lower with combined hypoxia and barbiturate anesthesia than with barbiturate anesthesia alone, although no significant differences were achieved. barbituric acid 185-196 proopiomelanocortin Homo sapiens 75-89 19215492-9 1991 The latter pattern was reversed in the nucleus tractus solitarii, in which beta-endorphin-like immunoreactivity and estimated beta-endorphin levels were lower with combined hypoxia and barbiturate anesthesia than with barbiturate anesthesia alone, although no significant differences were achieved. barbituric acid 185-196 proopiomelanocortin Homo sapiens 126-140 19215492-9 1991 The latter pattern was reversed in the nucleus tractus solitarii, in which beta-endorphin-like immunoreactivity and estimated beta-endorphin levels were lower with combined hypoxia and barbiturate anesthesia than with barbiturate anesthesia alone, although no significant differences were achieved. barbituric acid 218-229 proopiomelanocortin Homo sapiens 75-89 1959128-2 1991 All drugs, except barbituric acid and Na-barbital, inhibited the thrombin-induced intracellular Ca2+ rise. barbituric acid 18-33 coagulation factor II Rattus norvegicus 65-73 2219215-0 1990 Therapeutic window of CA1 neuronal damage defined by an ultrashort-acting barbiturate after brain ischemia in gerbils. barbituric acid 74-85 carbonic anhydrase 1 Homo sapiens 22-25 2389654-5 1990 The barbiturate increased the amplitudes of subcortical and early cortical components (N18, N20, P22, P25), whose latencies, however, were not significantly modified. barbituric acid 4-15 tubulin polymerization promoting protein Homo sapiens 102-105 2131184-7 1990 4. on the therapeutic level: the attacks resist barbiturate and benzodiazepin treatment in 80% of the cases, but the attacks diminish as the diabetes is brought under control through insulin treatment. barbituric acid 48-59 insulin Homo sapiens 183-190 2139484-7 1990 From these results, it would appear that a) isotonic saline alone does not stimulate IR-ANF release when used to expand blood volume, and b) barbiturate anesthesia significantly lowers resting plasma IR-ANF levels and attenuates the release of IR-ANF in response to volume expansion. barbituric acid 141-152 natriuretic peptide A Rattus norvegicus 203-206 2139484-7 1990 From these results, it would appear that a) isotonic saline alone does not stimulate IR-ANF release when used to expand blood volume, and b) barbiturate anesthesia significantly lowers resting plasma IR-ANF levels and attenuates the release of IR-ANF in response to volume expansion. barbituric acid 141-152 natriuretic peptide A Rattus norvegicus 203-206 35420113-4 2022 Electrochemical thiocyanation of barbituric acids starts with the generation of (SCN)2 from the thiocyanate anion. barbituric acid 33-49 growth factor independent 1 transcriptional repressor Homo sapiens 81-86 34120709-2 2021 Although the reference barbiturate thiopental had several limitations, it dominated the scene of the intravenous anesthesia until the mid-1980s, when propofol was introduced on the market. barbituric acid 23-34 3-hydroxyanthranilate 3,4-dioxygenase Homo sapiens 46-49 2163031-2 1990 In barbiturate anaesthetized spinal cats antibody microprobes were used to examine release of immunoreactive neurokinin A following cutaneous thermal and mechanical stimulation. barbituric acid 3-14 tachykinin precursor 1 Homo sapiens 109-121 2215924-7 1990 The number of Fos-positive cells seen at 8 h was increased by local anaesthetic blockade of the peripheral nerve after stimulation, and reduced by continuous barbiturate anaesthesia. barbituric acid 158-169 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 14-17 10227851-5 1999 Inhibition of GLUT-1 by barbiturates correlates with their overall lipid solubility and pharmacology, and requires hydrophobic side chains on the core barbiturate structure. barbituric acid 24-35 solute carrier family 2 member 1 Homo sapiens 14-20 34884482-6 2021 When embedded into a hydrophobic polymer such as polyisobutylene, a largely different rheological behavior was observed for the barbiturate-bearing PB compared to the thiobarbiturate-bearing PTB polymers, indicative of a stronger hydrogen bonding in the thioanalogue PTB. barbituric acid 128-139 polypyrimidine tract binding protein 1 Homo sapiens 267-270 34170704-2 2021 The GAs of C-H (1330.9 +- 10.0 kJ mol-1) and N-H (1361.5 +- 10.5 kJ mol-1) deprotonated sites of bifunctional barbituric acid were determined from the selective production of their corresponding heterodimers. barbituric acid 110-125 PAXIP1 associated glutamate rich protein 1 Homo sapiens 4-7 35490584-0 2022 Discovery of cinnamamide-barbiturate hybrids as a novel class of Nrf2 activator against myocardial ischemia/reperfusion injury. barbituric acid 25-36 NFE2 like bZIP transcription factor 2 Rattus norvegicus 65-69 35490584-12 2022 These findings provide a new perspective for designing cinnamamide-barbiturate hybrids as a novel class of Nrf2 activator against cardiovascular diseases. barbituric acid 67-78 NFE2 like bZIP transcription factor 2 Rattus norvegicus 107-111 2483867-6 1989 In cases in which barbiturate therapy was effective, the appearance of ALP-I was delayed and its elevation was suppressed. barbituric acid 18-29 alkaline phosphatase, intestinal Homo sapiens 71-76 2809624-4 1989 Barbiturate treatment, which previously has been shown to prevent delayed neuronal death in CA1 sector, did not ameliorate the initial inhibition of protein synthesis but it significantly improved subsequent recovery, especially in the vulnerable CA1 sector of hippocampus. barbituric acid 0-11 carbonic anhydrase 1 Homo sapiens 92-95 2809624-4 1989 Barbiturate treatment, which previously has been shown to prevent delayed neuronal death in CA1 sector, did not ameliorate the initial inhibition of protein synthesis but it significantly improved subsequent recovery, especially in the vulnerable CA1 sector of hippocampus. barbituric acid 0-11 carbonic anhydrase 1 Homo sapiens 247-250 2741747-1 1989 The behaviour of Pial vessels to levels of CSF-pressure between 10 and 100 mmHg induced by vetricular infusion of mock CSF, was observed in 6 cats under barbiturate and N2O anaesthesia, using the cranial window technique and videoangiometry. barbituric acid 153-164 granulocyte-macrophage colony-stimulating factor Felis catus 119-122 20501189-1 1987 By use of membrane preparations and incubation conditions optimized for each binding site, we have characterized the benzodiazepine and ionophore-linked-convulsant/barbiturate modulatory sites within the chick tectal GABA(A) receptor complex. barbituric acid 164-175 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 217-233 3034390-1 1987 Barbiturate actions on excitatory synaptic responses in CA 1 and dentate regions of hippocampal slices were studied to determine whether different effects occur on anatomically distinct synaptic pathways. barbituric acid 0-11 carbonic anhydrase 1 Homo sapiens 56-60 3040981-1 1987 The GABA receptor of mammalian brain is a ligand-gated channel protein with allosteric binding sites for the benzodiazepines and barbiturate drugs. barbituric acid 130-141 GABA type A receptor-associated protein Homo sapiens 4-18 3573977-0 1987 Occurrence of a barbiturate-inducible catalytically self-sufficient 119,000 dalton cytochrome P-450 monooxygenase in bacilli. barbituric acid 16-27 cytochrome P450 Bacillus megaterium NBRC 15308 = ATCC 14581 83-99 2949310-3 1987 A situation analogous to the latent stage of human hepatic porphyria can be produced in chick embryos by injecting an inhibitor of ferrochelatase (the last enzyme in the heme biosynthesis pathway); the simultaneous injection of a porphyrinogenic drug (e.g. barbiturate) results in a strong increase of liver porphyrin levels, as is found in human hepatic porphyrias. barbituric acid 257-268 ferrochelatase Gallus gallus 131-145 3439474-5 1987 The results obtained show that the hydroxylamine derivatives of barbituric acid HB-2 (2-hydroxylamino-5-ethyl-5-propylbarbituric acid) and HB-7 (2-hydroxylamino-5-ethyl-5 sec. barbituric acid 64-79 activated leukocyte cell adhesion molecule Rattus norvegicus 80-84 2431244-0 1986 Barbiturate and benzodiazepine modulation of GABA receptor binding and function. barbituric acid 0-11 GABA type A receptor-associated protein Homo sapiens 45-58 3512818-1 1986 The influence of interrupting the renin-angiotensin system on the renal hemodynamic response to barbiturate anesthesia was assessed in conscious, trained, chronically catheterized rats. barbituric acid 96-107 renin Rattus norvegicus 34-39 2427161-4 1986 However, a barbiturate site is most probably present in the GABA receptor complexes since pentobarbitone (10(-4) M) was able to stimulate 36Cl- permeability to the same extent as GABA itself. barbituric acid 11-22 GABA type A receptor-associated protein Homo sapiens 60-73 3005493-4 1986 Both pyrazolopyridine (SQ 65,396)- and barbiturate (pentobarbital)-enhanced [3H]flunitrazepam binding and [35S]t-butylbicyclophosphorothionate (TBPS) binding were markedly reduced by as little as 0.0025-0.005 U/ml of PLA2. barbituric acid 39-50 phospholipase A2 group IB Homo sapiens 217-221 3921972-6 1985 These results indicate that in the barbiturate-treated hamster the elevated follicular fluid levels of progesterone precede by 1-2 days the previously reported increase in steroidogenic capability of delayed follicles to produce progesterone in vitro; this correlated with an increase in the ratio of hCG:FSH binding and this was mostly due to a decrease in FSH binding to whole follicles. barbituric acid 35-46 hypertrichosis 2 (generalised, congenital) Homo sapiens 301-304 2996510-4 1985 In addition, three compounds, 5-azaorotate, 5-bromoorotate, and barbiturate were also inhibitory against the two subsequent enzymes of the pathway, orotate phosphoribosyltransferase and orotidylate decarboxylase, so that they could act against three enzymes of the mammalian pyrimidine de novo biosynthetic pathway. barbituric acid 64-75 uridine monophosphate synthetase Homo sapiens 148-181 3002843-2 1985 It was proved experimentally that the barbiturate favoured marked prevention of the decrease of the content of cytochrome P-450 and iron-sulfur proteins, thereby protecting the detoxifying and energy liver system from dinitrophenol-induced injuries. barbituric acid 38-49 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 111-127 3968557-3 1985 The half-life (t 1/2) for MP during barbiturate and hyperventilation therapy was found to be reduced by a mean 55% (p less than 0.01) in relation to the t 1/2 of MP when administered alone. barbituric acid 36-47 interleukin 1 receptor like 1 Homo sapiens 15-18 3968557-4 1985 Studies on the day after termination of barbiturate intake indicated a tendency for an increase in the t 1/2 of MP, but it was not significantly different from the pretermination assessment (p greater than 0.05). barbituric acid 40-51 interleukin 1 receptor like 1 Homo sapiens 103-114 6435683-0 1984 Acylureas: a new class of barbiturate-like bacterial cytochrome P-450 inducers. barbituric acid 26-37 cytochrome P450 Bacillus megaterium NBRC 15308 = ATCC 14581 53-69 7276905-0 1981 The use of quantitative structure-activity relationships as an aid to the interpretation of blood levels in cases of fatal barbiturate. barbituric acid 123-134 activation induced cytidine deaminase Homo sapiens 63-66 6148413-2 1984 The antidiuretic response to amyl nitrite was accompanied by increased urinary excretion of vasopressin, it was blocked by a specific vasopressin antagonist and by a barbiturate and it was absent in the Brattleboro rat with congenital diabetes insipidus. barbituric acid 166-177 arginine vasopressin Rattus norvegicus 92-103 6577471-5 1983 Ligation of the external carotid and lingual arteries at 24 hr postdenervation was found to oppose the preservation of acetylcholinesterase and butyrylcholinesterase contents of the ganglia induced by barbiturate anesthesia. barbituric acid 201-212 butyrylcholinesterase Felis catus 144-165 6469956-0 1984 Competition between hydrocarbon and barbiturate for spectral binding to hepatic cytochrome P-450. barbituric acid 36-47 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 80-96 6129770-7 1982 Among a wide range of other CNS active compounds tested, CAR was inhibited by alpha 1-adrenergic antagonists, benzodiazepines, a barbiturate, GABA agonists, morphine and a serotonin agonist, but in doses inducing other motor disturbances. barbituric acid 129-140 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 57-60 6811264-3 1982 Both enzymes were induced by phenobarbital treatment of the animals: administration of the barbiturate for 4 days, produced a 150% increase in the cytochrome P-450 content and in the specific activity of UDP-glucuronosyltransferase. barbituric acid 91-102 cytochrome P-450 Oryctolagus cuniculus 147-163 6811264-3 1982 Both enzymes were induced by phenobarbital treatment of the animals: administration of the barbiturate for 4 days, produced a 150% increase in the cytochrome P-450 content and in the specific activity of UDP-glucuronosyltransferase. barbituric acid 91-102 UDP-glucuronosyltransferase 2C1 Oryctolagus cuniculus 204-231 824652-11 1976 These results extend earlier work in rodents to primates and suggest a possible use of TRH in cases of acute barbiturate intoxication. barbituric acid 109-120 thyrotropin releasing hormone Macaca mulatta 87-90 6452561-0 1980 Prevention of barbiturate-mediated increases of rat hepatic ornithine decarboxylase and delta-aminolevulinic acid synthetase activities by nicotinic acid and nicotinamide. barbituric acid 14-25 ornithine decarboxylase 1 Rattus norvegicus 60-83 6153956-7 1980 During barbiturate anaesthesia the SEP showed the characteristic change of the P49 component and enhancement of P32, while during the seizure induced by right ECT, the SEP was seen more clearly on the left side of the head, despite the high voltage epileptic activity. barbituric acid 7-18 DNA primase subunit 1 Homo sapiens 79-82 7448058-0 1980 Effects of a single dose of barbiturate on prolactin secretion in woman. barbituric acid 28-39 prolactin Homo sapiens 43-52 7448058-1 1980 Barbiturate administration (100 mg% m2 body surface) decreases PRL levels in serum during night surge. barbituric acid 0-11 prolactin Homo sapiens 63-66 7378239-0 1980 Half-life of angiotensin II in the conscious and barbiturate-anaesthetized rat. barbituric acid 49-60 angiotensinogen Rattus norvegicus 13-27 824652-7 1976 TRH administration resulted in dramatically increased respiration and heart rates and arrested the progress of barbiturate induced hypothermia. barbituric acid 111-122 thyrotropin releasing hormone Macaca mulatta 0-3 6260535-4 1981 Thyrotropin-releasing hormone, injected centrally at submicrogram doses, produced in nondependent, barbiturate-anesthetized animals, shaking behavior identical in its general features to that of morphine withdrawal. barbituric acid 99-110 thyrotropin releasing hormone Homo sapiens 0-29 98247-0 1978 Thyrotrophin, prolactin and growth hormone responses to TRH in barbiturate coma and in depression. barbituric acid 63-74 growth hormone 1 Homo sapiens 28-42 98247-0 1978 Thyrotrophin, prolactin and growth hormone responses to TRH in barbiturate coma and in depression. barbituric acid 63-74 thyrotropin releasing hormone Homo sapiens 56-59 98247-3 1978 The patients with barbiturate coma presented normal basal TSH and PRL, elevated basal GH and normal PRL but blunted TSH responses to TRH; their GH concentrations varied widely without consistent relation to TRH administration. barbituric acid 18-29 prolactin Homo sapiens 66-69 98247-3 1978 The patients with barbiturate coma presented normal basal TSH and PRL, elevated basal GH and normal PRL but blunted TSH responses to TRH; their GH concentrations varied widely without consistent relation to TRH administration. barbituric acid 18-29 growth hormone 1 Homo sapiens 86-88 98247-3 1978 The patients with barbiturate coma presented normal basal TSH and PRL, elevated basal GH and normal PRL but blunted TSH responses to TRH; their GH concentrations varied widely without consistent relation to TRH administration. barbituric acid 18-29 prolactin Homo sapiens 100-103 98247-3 1978 The patients with barbiturate coma presented normal basal TSH and PRL, elevated basal GH and normal PRL but blunted TSH responses to TRH; their GH concentrations varied widely without consistent relation to TRH administration. barbituric acid 18-29 thyrotropin releasing hormone Homo sapiens 133-136 98247-3 1978 The patients with barbiturate coma presented normal basal TSH and PRL, elevated basal GH and normal PRL but blunted TSH responses to TRH; their GH concentrations varied widely without consistent relation to TRH administration. barbituric acid 18-29 growth hormone 1 Homo sapiens 144-146 98247-8 1978 It is concluded that the abnormal TSH and GH responses to TRH observed in patients with barbiturate coma are more likely related to depressive illness than to an effect of barbiturates at the pituitary level. barbituric acid 88-99 growth hormone 1 Homo sapiens 42-44 98247-8 1978 It is concluded that the abnormal TSH and GH responses to TRH observed in patients with barbiturate coma are more likely related to depressive illness than to an effect of barbiturates at the pituitary level. barbituric acid 88-99 thyrotropin releasing hormone Homo sapiens 58-61 871092-4 1977 Both ethanol and APL potentiated the effect of barbiturate narcosis, but the combined pretreatment was not more effective. barbituric acid 47-58 neuraminidase 1 Mus musculus 17-20 403528-3 1977 TRH significantly altered all physiological indices except heart rate in both barbiturate- and saline-pretreated animals. barbituric acid 78-89 thyrotropin releasing hormone Oryctolagus cuniculus 0-3 1191255-4 1975 Studies of the effects on the reaction of activators of acrosin (Ca2+, water-miscible solvents) showed that titrations carried out in barbiturate buffer containing 1M-CaCl2 and diluted with 0.2 vol. barbituric acid 134-145 acrosin Homo sapiens 56-63 189324-2 1976 Thytrotopin-releasing hormone (TRH), for example, antagonizes the sedation and hypothermia produced by barbiturate and other depressant drugs and de Wied has shown that ACTH 4-10, TRH, LHRH and certain related substances show some activity in inhibition of extinction of a pole-jumping avoidance response in the rat. barbituric acid 103-114 thyrotropin releasing hormone Rattus norvegicus 0-29 189324-2 1976 Thytrotopin-releasing hormone (TRH), for example, antagonizes the sedation and hypothermia produced by barbiturate and other depressant drugs and de Wied has shown that ACTH 4-10, TRH, LHRH and certain related substances show some activity in inhibition of extinction of a pole-jumping avoidance response in the rat. barbituric acid 103-114 thyrotropin releasing hormone Rattus norvegicus 31-34 189324-2 1976 Thytrotopin-releasing hormone (TRH), for example, antagonizes the sedation and hypothermia produced by barbiturate and other depressant drugs and de Wied has shown that ACTH 4-10, TRH, LHRH and certain related substances show some activity in inhibition of extinction of a pole-jumping avoidance response in the rat. barbituric acid 103-114 thyrotropin releasing hormone Rattus norvegicus 180-183 189324-2 1976 Thytrotopin-releasing hormone (TRH), for example, antagonizes the sedation and hypothermia produced by barbiturate and other depressant drugs and de Wied has shown that ACTH 4-10, TRH, LHRH and certain related substances show some activity in inhibition of extinction of a pole-jumping avoidance response in the rat. barbituric acid 103-114 gonadotropin releasing hormone 1 Rattus norvegicus 185-189 1239780-4 1975 CAR-performance generally deteriorated in the early drug phase but improved to near normalcy during the late drug and withdrawal phases in all groups except for alcohol and barbiturate-treated one. barbituric acid 173-184 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 0-3 816658-2 1976 Bilateral administration of 0.011-2.0 mug TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, whereas N1im-methyl TRH was approximately 10X less potent than TRH. barbituric acid 110-121 thyrotropin releasing hormone Rattus norvegicus 42-45 816658-2 1976 Bilateral administration of 0.011-2.0 mug TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, whereas N1im-methyl TRH was approximately 10X less potent than TRH. barbituric acid 110-121 thyrotropin releasing hormone Rattus norvegicus 163-166 816658-2 1976 Bilateral administration of 0.011-2.0 mug TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, whereas N1im-methyl TRH was approximately 10X less potent than TRH. barbituric acid 110-121 thyrotropin releasing hormone Rattus norvegicus 163-166 816658-2 1976 Bilateral administration of 0.011-2.0 mug TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, whereas N1im-methyl TRH was approximately 10X less potent than TRH. barbituric acid 110-121 thyrotropin releasing hormone Rattus norvegicus 163-166 816658-2 1976 Bilateral administration of 0.011-2.0 mug TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, whereas N1im-methyl TRH was approximately 10X less potent than TRH. barbituric acid 110-121 thyrotropin releasing hormone Rattus norvegicus 163-166 1191255-3 1975 Titration in sodium barbiturate buffer of acrosin, a serine proteinase from sperm acrosomes, with the ester substrate 4-methylumbelliferyl p-guanidinobenzoate gave rise to an incomplete "burst" of 4-methylumbelliferone. barbituric acid 13-31 acrosin Homo sapiens 42-49 805836-2 1975 While 3 to 100 mg/kg of TRH reduced pentobarbital sleeping time when administered prior to the barbiturate, a dose-response relationship to TRH could not be established. barbituric acid 95-106 thyrotropin releasing hormone Homo sapiens 24-27 4434580-0 1974 C-13 NMR spectra of barbituric acid derivatives. barbituric acid 20-35 homeobox C13 Homo sapiens 0-4 817374-1 1975 Previous work has demonstrated that thyrotropin-releasing hormone (TRH) and its beta-alanine analogue (beta-ala TRH) are potent antagonists of barbiturate-induced sedation. barbituric acid 143-154 thyrotropin releasing hormone Mus musculus 36-65 817374-1 1975 Previous work has demonstrated that thyrotropin-releasing hormone (TRH) and its beta-alanine analogue (beta-ala TRH) are potent antagonists of barbiturate-induced sedation. barbituric acid 143-154 thyrotropin releasing hormone Mus musculus 67-70 817374-1 1975 Previous work has demonstrated that thyrotropin-releasing hormone (TRH) and its beta-alanine analogue (beta-ala TRH) are potent antagonists of barbiturate-induced sedation. barbituric acid 143-154 thyrotropin releasing hormone Mus musculus 112-115 817374-6 1975 Since phenobarbital treatment of grand mal epilepsy is often limited by sedation and since TRH antogonizes sedation and enhances anticonvulsant effects of the barbiturate, the hormone or a congener may find value as an adjunct in therapy. barbituric acid 159-170 thyrotropin releasing hormone Mus musculus 91-94 4421042-0 1974 Cortical synchronization evoked by noxious bradykinin stimulation under barbiturate anesthesia. barbituric acid 72-83 kininogen 1 Homo sapiens 43-53 4402992-0 1972 A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase. barbituric acid 54-70 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 88-112 4268854-0 1973 Effect of barbiturate on MG ++ -dependent ATPase in human erythrocytes. barbituric acid 10-21 dynein axonemal heavy chain 8 Homo sapiens 42-48 13766142-0 1960 [Behavior of the C-reactive protein in relation to barbiturate anesthesia for minor gynecological operations]. barbituric acid 51-62 C-reactive protein Homo sapiens 17-35 5181762-0 1967 [First aid in acute barbiturate poisoning]. barbituric acid 20-31 activation induced cytidine deaminase Homo sapiens 7-10 13555602-0 1958 [Effect of barbiturate anesthesia on urinary excretion of C21-alpha-ketols]. barbituric acid 11-22 endogenous retrovirus group K member 23 Homo sapiens 58-67 13405558-0 1957 Adrenocorticotropic hormone (ACTH) in the treatment of barbiturate poisoning. barbituric acid 55-66 proopiomelanocortin Homo sapiens 0-27 13701834-0 1961 [Effects of N-1-methylation and/or C-2-sulfuration on the narcotic action, toxicity and metabolism of a barbituric acid derivative]. barbituric acid 104-119 complement C2 Homo sapiens 35-38 28907954-0 1959 Prolonged Coma in Barbiturate Poisoning. barbituric acid 18-29 COMA Homo sapiens 10-14 13547608-0 1957 [Effect of barbiturate derivatives on post-insulin and post-reserpine gastric hypersecretion in dogs]. barbituric acid 11-22 insulin Canis lupus familiaris 43-50 13433040-0 1956 [Behavior of adenosinetriphosphatase activity in acute experimental barbiturate poisoning (luminal)]. barbituric acid 68-79 ATPase Na+/K+ transporting subunit beta 1 Homo sapiens 13-36 13238950-1 1955 Cases of coma following administration of barbiturate potentiated by autonomic drugs after insulin shock therapy]. barbituric acid 42-53 insulin Homo sapiens 91-98 33352334-6 2021 In this work, we synthesized and applied barbituric and thiobarbituric acid-based chromene derivatives, as new fluorescent dyes to quantitatively detect the amyloid fibrils of bovine serum albumin (BSA) and human insulin in comparison with native soluble proteins or amorphous aggregation. barbituric acid 41-51 albumin Homo sapiens 183-196 33790996-6 2021 The results indicated that anesthetic agents, including sodium barbiturate, ketamine and propofol, but not midazolam and etomidate, exerted significant inhibitory effects on NF-kappaB expression in the three different cell lines. barbituric acid 56-74 nuclear factor kappa B subunit 1 Homo sapiens 174-183 33790996-7 2021 Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18. barbituric acid 0-18 nuclear factor kappa B subunit 1 Homo sapiens 86-95 33790996-7 2021 Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18. barbituric acid 0-18 interleukin 1 alpha Homo sapiens 128-136 33790996-7 2021 Sodium barbiturate, ketamine and propofol also decreased the expression levels of the NF-kappaB downstream cytokines, including IL-1beta and IL-18. barbituric acid 0-18 interleukin 18 Homo sapiens 141-146 33790996-8 2021 Moreover, sodium barbiturate, ketamine and propofol reduced the effect of TNF-alpha on inflammatory activity in the three cell lines. barbituric acid 10-28 tumor necrosis factor Homo sapiens 74-83 33352334-6 2021 In this work, we synthesized and applied barbituric and thiobarbituric acid-based chromene derivatives, as new fluorescent dyes to quantitatively detect the amyloid fibrils of bovine serum albumin (BSA) and human insulin in comparison with native soluble proteins or amorphous aggregation. barbituric acid 41-51 insulin Homo sapiens 213-220 32466182-12 2020 This study shows that the barbiturate scaffold is suitable for hybrid design as an MMP-9 inhibitor in cytokine-stimulated Caco-2 cells. barbituric acid 26-37 matrix metallopeptidase 9 Homo sapiens 83-88 32156165-1 2020 A new series of thiobarbituric (thiopyrimidine trione) enamine derivatives and its analogues barbituric acid derivatives was synthesised, characterised, and screen for in vitro evaluation of alpha-glucosidase enzyme inhibition and anti-glycation activity. barbituric acid 93-108 sucrase-isomaltase Homo sapiens 191-208 32920355-0 2020 Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. barbituric acid 29-39 poly(ADP-ribose) polymerase 1 Homo sapiens 124-129 32716521-8 2020 Previous publications using barbiturate anaesthetised G93A SOD1 mice suggested that some motoneurones are hypo-excitable, defined by deficits in repetitive firing. barbituric acid 28-39 superoxide dismutase 1, soluble Mus musculus 59-63 32466182-0 2020 Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway. barbituric acid 6-17 matrix metallopeptidase 9 Homo sapiens 64-90 32296336-0 2020 Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-kappaB Signaling Pathway in Hepatic Stellate Cells. barbituric acid 26-41 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 87-96 32466182-2 2020 Barbiturate nitrate hybrid compounds have been designed to inhibit MMP secretion and enzyme activity. barbituric acid 0-11 matrix metallopeptidase 1 Homo sapiens 67-70 32296336-5 2020 In this study, we synthesized a series of six barbituric acid (BA) derivatives, and one of the compounds, BA-5, exhibited the best ability to ameliorate TGF-beta1-induced HSC activation without overt cytotoxic effects. barbituric acid 46-61 transforming growth factor, beta 1 Mus musculus 153-162 32296336-5 2020 In this study, we synthesized a series of six barbituric acid (BA) derivatives, and one of the compounds, BA-5, exhibited the best ability to ameliorate TGF-beta1-induced HSC activation without overt cytotoxic effects. barbituric acid 63-65 transforming growth factor, beta 1 Mus musculus 153-162 32296336-13 2020 In conclusion, our study showed that the barbituric acid derivative BA-5 inhibits HSCs activation and liver fibrosis by blocking both the TGF-beta1 and LPS-induced NF-kappaB signaling pathways and further inhibits macrophages recruitment and activation. barbituric acid 41-56 transforming growth factor, beta 1 Mus musculus 138-147 32296336-13 2020 In conclusion, our study showed that the barbituric acid derivative BA-5 inhibits HSCs activation and liver fibrosis by blocking both the TGF-beta1 and LPS-induced NF-kappaB signaling pathways and further inhibits macrophages recruitment and activation. barbituric acid 41-56 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 164-173 27853314-3 2016 Further, bisulphite sequencing revealed critical CpG methylation changes in BARBIE BOX (Barbiturate response element) and BTE (Basal transcription element) in promoter of CYP2B1 in the brain isolated from rechallenged animals. barbituric acid 88-99 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 171-177 30125561-7 2018 Barbiturate-induced scratching was inhibited not only by GABAA receptor antagonists but also by an L-type voltage-dependent calcium channel (L-VDCC) agonist and an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor agonist. barbituric acid 0-11 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 57-62 30125561-10 2018 Overall, our results suggest that a synergistic effect among AMPA receptor inhibition, GABAA receptor activation, and L-VDCC inhibition in the brain mediates barbiturate-induced scratching in atopic dermatitis mice. barbituric acid 158-169 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 87-92 31288170-2 2019 Molecular dynamics simulations have successfully explained that CB-1 exhibits the best aggregate induced emission (AIE) activity due to the electron-deficient barbituric acid and the electron-rich carbazole exhibit a conformation which similar to pi-pi stacking, resulting in a strong electrostatic attraction between the molecules, meanwhile the N-atom substituent of the carbazole is n-propane plays a hydrophobic role. barbituric acid 159-174 cannabinoid receptor 1 Homo sapiens 64-68 27585936-9 2016 The ADA/DAD synthon was succesfully formed in the salt of barbituric acid, i.e. (V), as well as in the salts of 2-thiobarbituric acid, i.e. (VI) and (VII). barbituric acid 58-73 adenosine deaminase Homo sapiens 4-7 27857927-0 2016 A Fatal Adverse Effect of Barbiturate Coma Therapy: Dyskalemia. barbituric acid 26-37 COMA Homo sapiens 38-42 26719553-1 2015 The work was aimed for the ascertainment of following question - whether Orexin-containing neurons of dorsal and lateral hypothalamus and brain Orexinergic system in general are those cellular targets which can accelerate recovery of disturbed sleep homeostasis and restoration of sleep-wakefulness cycle behavioral states from barbiturate anesthesia-induced artificial sleep. barbituric acid 328-339 hypocretin neuropeptide precursor Rattus norvegicus 73-79 27302770-2 2016 One of the most effective hit compounds was BC12, a barbituric acid-based molecule that exhibits unusually potent immunosuppressive and immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production. barbituric acid 52-67 interleukin 2 Homo sapiens 236-240 27585936-4 2016 We report the results of cocrystallization experiments of barbituric acid and 2-thiobarbituric acid, respectively, with 2,4-diaminopyrimidine, which contains a complementary DAD hydrogen-bonding site and is therefore capable of forming an ADA/DAD synthon with barbituric acid and 2-thiobarbituric acid. barbituric acid 58-73 adenosine deaminase Homo sapiens 239-242 27585936-4 2016 We report the results of cocrystallization experiments of barbituric acid and 2-thiobarbituric acid, respectively, with 2,4-diaminopyrimidine, which contains a complementary DAD hydrogen-bonding site and is therefore capable of forming an ADA/DAD synthon with barbituric acid and 2-thiobarbituric acid. barbituric acid 84-99 adenosine deaminase Homo sapiens 239-242 26708109-0 2016 Design and synthesis of novel Y-shaped barbituric acid derivatives as PPARgamma activators. barbituric acid 39-54 peroxisome proliferator activated receptor gamma Homo sapiens 70-79 26708109-7 2016 The most significant finding of our study is that BA derivatives with symmetrically substituted weakly polar side chains result in the desired moderate level of PPARgamma binding affinities. barbituric acid 50-52 peroxisome proliferator activated receptor gamma Homo sapiens 161-170 26719553-7 2015 According to obtained new evidences, serial electrical stimulations of dorsal and lateral hypothalamic Orexin-containing neurons significantly accelerate recovery of wakefulness, sleep homeostasis, disturbed because of barbiturate anesthesia induced artificial sleep and different behavioral states of sleep-wakefulness cycle. barbituric acid 219-230 hypocretin neuropeptide precursor Rattus norvegicus 103-109 26719553-8 2015 Hypothalamic Orexin-containing neurons can be considered as the cellular targets for regulating of sleep homeostasis through the acceleration of recovery of wakefulness, and SWC in general, from barbiturate anesthesia-induced deep sleep. barbituric acid 195-206 hypocretin neuropeptide precursor Rattus norvegicus 13-19 26378885-0 2015 Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the alpha1 beta3 gamma2L GABAA receptor account for their in vivo effects. barbituric acid 36-47 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 110-115 26378885-12 2015 We recently located the anaesthetic sites on GABAA receptors (GABAA Rs) by photolabelling with an anaesthetic barbiturate. barbituric acid 110-121 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 45-50 26378885-12 2015 We recently located the anaesthetic sites on GABAA receptors (GABAA Rs) by photolabelling with an anaesthetic barbiturate. barbituric acid 110-121 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 62-67 26378885-23 2015 Interactions with these two classes of barbiturate binding sites on GABAA Rs underlie the enantiomers" different pharmacological activities in mice. barbituric acid 39-50 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 68-73 26054198-12 2015 CONCLUSION: Acupuncture stimulation of CV 12, ST 36, KI 6 and BL 62 can relieve the gastric mucosal lesion, and shorten barbiturate-induced sleeping time in gastric ulcer rats, which may be related to its effects in reducing TNF-alpha and IL-25 contents in the serum and hippocampus tissues, suggesting a correlation between the gastrointestinal disorder and sleeping. barbituric acid 120-131 tumor necrosis factor Rattus norvegicus 225-234 26204057-2 2015 Improved over the previously reported chrysin-indole-pyrazole conjugates and also in comparison to the chrysin, indole, and barbituric acid based COX-2 inhibitors, the new compounds have displayed significantly better IC50 for COX-2 and some of them also exhibited inhibition of 5-LOX enzyme. barbituric acid 124-139 cytochrome c oxidase II, mitochondrial Mus musculus 146-151 26103205-1 2015 A new array of near-infrared probes containing barbituric acid acceptors has been developed as Abeta imaging agents. barbituric acid 47-62 histocompatibility 2, class II antigen A, beta 1 Mus musculus 95-100 26054198-12 2015 CONCLUSION: Acupuncture stimulation of CV 12, ST 36, KI 6 and BL 62 can relieve the gastric mucosal lesion, and shorten barbiturate-induced sleeping time in gastric ulcer rats, which may be related to its effects in reducing TNF-alpha and IL-25 contents in the serum and hippocampus tissues, suggesting a correlation between the gastrointestinal disorder and sleeping. barbituric acid 120-131 interleukin 25 Rattus norvegicus 239-244 23651412-3 2013 We recently identified pyrimidinetriones (PYTs) as a CaV1.3-selective scaffold; here we report the structure-activity relationship of PYTs with both CaV1.3 and CaV1.2 LTCCs. barbituric acid 23-40 calcium voltage-gated channel subunit alpha1 D Homo sapiens 149-155 24300193-0 2014 Effect of Cd, Zn and Hg complexes of barbituric acid and thiouracil on rat brain monoamine oxidase-B (in vitro). barbituric acid 37-52 monoamine oxidase B Rattus norvegicus 81-100 23651412-3 2013 We recently identified pyrimidinetriones (PYTs) as a CaV1.3-selective scaffold; here we report the structure-activity relationship of PYTs with both CaV1.3 and CaV1.2 LTCCs. barbituric acid 23-40 calcium voltage-gated channel subunit alpha1 D Homo sapiens 53-59 25441899-1 2014 In this study, we synthesized CTB and CB probes based on doubly activated Michael acceptors to selectively detect cyanide (CN(-)) anions through a one-step condensation reaction of coumarinyl acrylaldehyde with the corresponding derivatives of malonyl urea (thiourea). barbituric acid 244-256 chitobiase Homo sapiens 30-33 24715100-0 2014 Colorimetric barbiturate sensing with hybrid spin crossover assemblies. barbituric acid 13-24 spindlin 1 Homo sapiens 45-49 24715100-1 2014 Spin crossover complexes based on either iron(II) or iron(III) give a colorimetric response upon self-assembly with barbituric acids. barbituric acid 116-132 spindlin 1 Homo sapiens 0-4 23651412-3 2013 We recently identified pyrimidinetriones (PYTs) as a CaV1.3-selective scaffold; here we report the structure-activity relationship of PYTs with both CaV1.3 and CaV1.2 LTCCs. barbituric acid 23-40 calcium voltage-gated channel subunit alpha1 C Homo sapiens 160-166 21463618-0 2011 A novel agonist of PPAR-gamma based on barbituric acid alleviates the development of non-alcoholic fatty liver disease by regulating adipocytokine expression and preventing insulin resistance. barbituric acid 39-54 peroxisome proliferator activated receptor gamma Homo sapiens 19-29 21429633-1 2011 Forty-four barbituric acid or thiobarbituric acid derivatives were synthesized and evaluated for their effects on adipogenesis of 3T3-L1 adipocytes by measuring the expression of adiponectin in vitro. barbituric acid 11-26 adiponectin, C1Q and collagen domain containing Rattus norvegicus 179-190 22467201-2 2012 The results revealed that MAO-B was activated by BA, DEBA, TBA, TU, and ATU, and the activation was structural, concentration, and time dependent. barbituric acid 49-51 monoamine oxidase B Rattus norvegicus 26-31 21463618-0 2011 A novel agonist of PPAR-gamma based on barbituric acid alleviates the development of non-alcoholic fatty liver disease by regulating adipocytokine expression and preventing insulin resistance. barbituric acid 39-54 insulin Homo sapiens 173-180 21463618-2 2011 Recently, a new series of PPARgamma ligands based on barbituric acid has been designed, in which 5-(4-(benzyloxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (SKLB102) showed a high affinity with PPARgamma. barbituric acid 53-68 peroxisome proliferator activated receptor gamma Homo sapiens 26-35 21463618-2 2011 Recently, a new series of PPARgamma ligands based on barbituric acid has been designed, in which 5-(4-(benzyloxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (SKLB102) showed a high affinity with PPARgamma. barbituric acid 53-68 peroxisome proliferator activated receptor gamma Homo sapiens 197-206 21422613-1 2011 High-resolution single-crystal X-ray diffraction measurements at 100 K were performed for the two polymorphs of urea-barbituric acid co-crystals: (I) P2(1)/c and (II) Cc. barbituric acid 117-132 cyclin dependent kinase inhibitor 1A Homo sapiens 150-169 21186251-0 2011 Barbituric acid derivative BAS 02104951 inhibits PKCepsilon, PKCeta, PKCepsilon/RACK2 interaction, Elk-1 phosphorylation in HeLa and PKCepsilon and eta translocation in PC3 cells following TPA-induction. barbituric acid 0-15 protein kinase C epsilon Homo sapiens 49-59 21302359-6 2011 The newly synthesized TRH analogues were also evaluated in vivo to assess their potencies in antagonism of barbiturate-induced sleeping time, and several analogues displayed potent analeptic activity. barbituric acid 107-118 thyrotropin releasing hormone Mus musculus 22-25 21186251-0 2011 Barbituric acid derivative BAS 02104951 inhibits PKCepsilon, PKCeta, PKCepsilon/RACK2 interaction, Elk-1 phosphorylation in HeLa and PKCepsilon and eta translocation in PC3 cells following TPA-induction. barbituric acid 0-15 protein kinase C epsilon Homo sapiens 69-79 21186251-0 2011 Barbituric acid derivative BAS 02104951 inhibits PKCepsilon, PKCeta, PKCepsilon/RACK2 interaction, Elk-1 phosphorylation in HeLa and PKCepsilon and eta translocation in PC3 cells following TPA-induction. barbituric acid 0-15 ETS transcription factor ELK1 Homo sapiens 99-104 21186251-0 2011 Barbituric acid derivative BAS 02104951 inhibits PKCepsilon, PKCeta, PKCepsilon/RACK2 interaction, Elk-1 phosphorylation in HeLa and PKCepsilon and eta translocation in PC3 cells following TPA-induction. barbituric acid 0-15 protein kinase C epsilon Homo sapiens 69-79 21186251-0 2011 Barbituric acid derivative BAS 02104951 inhibits PKCepsilon, PKCeta, PKCepsilon/RACK2 interaction, Elk-1 phosphorylation in HeLa and PKCepsilon and eta translocation in PC3 cells following TPA-induction. barbituric acid 0-15 endothelin receptor type A Homo sapiens 64-67 20643195-2 2010 The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia. barbituric acid 280-291 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 66-69 20735421-4 2010 The pharmacology of the barbiturate pentobarbital (PB) in human recombinant alpha(1A) PQCCs has been characterized. barbituric acid 24-35 calcium voltage-gated channel subunit alpha1 A Homo sapiens 76-84