PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34726962-5	2022	Instead, H19 knock down was able to impede the ability of DACi to modulate the protein level of the autophagy markers.	daci	58-62	H19 imprinted maternally expressed transcript	Homo sapiens	9-12
34726962-6	2022	Furthermore, the administration of higher concentration of DACi was able to down-regulate the protein level of Beclin1 and p62 and to induce the conversion of LC3B-I into the active LC3B-II form, thus confirming an active autophagic process.	daci	59-63	beclin 1	Homo sapiens	111-118
34726962-6	2022	Furthermore, the administration of higher concentration of DACi was able to down-regulate the protein level of Beclin1 and p62 and to induce the conversion of LC3B-I into the active LC3B-II form, thus confirming an active autophagic process.	daci	59-63	nucleoporin 62	Homo sapiens	123-126
34726962-6	2022	Furthermore, the administration of higher concentration of DACi was able to down-regulate the protein level of Beclin1 and p62 and to induce the conversion of LC3B-I into the active LC3B-II form, thus confirming an active autophagic process.	daci	59-63	microtubule associated protein 1 light chain 3 beta	Homo sapiens	159-163
2992752-7	1985	This assay was also used to characterize a potentiated cell kill when etoposide is combined with cisplatin and to identify activity by a new compound, diazoacetylcholine iodide (DACI), which was synthesized as an agent targeted for SCCL cells.	daci	178-182	SCLC1	Homo sapiens	232-236
22895185-8	2012	In AML1/ETO or PLZF/RARalpha-positive 32D cells, DACi-mediated antiproliferative effects were associated with downregulation of BMI1 and c-MYC protein levels.	daci	49-53	runt related transcription factor 1	Mus musculus	3-7
32794577-8	2020	Importantly, one month following Mito-Plt transplantation, DACI was alleviated in db/db mice and the effect was accompanied with increased mitochondrial number, restored mitochondrial function, attenuated oxidative stress and neuronal apoptosis, as well as decreased accumulation of Abeta and Tau in the hippocampus.	daci	59-63	histocompatibility 2, class II antigen A, beta 1	Mus musculus	283-288
22943463-9	2012	CONCLUSION: We suggest a dual mode of action of DACi on DNA methylation status: a rapid inhibition of enzyme activity due to interference with posttranslational acetylation and a delayed effect on transcriptional control of DNMT genes by HDAC or miRNA mechanisms.	daci	48-52	DNA methyltransferase 1	Homo sapiens	224-228
22895185-6	2012	We show that the self-renewal and short-term repopulation capacity of AML1/ETO- or PLZF/RARalpha-expressing Sca1+/lin- stem and progenitor cells are profoundly inhibited by clinically applicable concentrations of the DACi dacinostat and vorinostat.	daci	217-221	RUNX family transcription factor 1	Homo sapiens	70-74
22895185-8	2012	In AML1/ETO or PLZF/RARalpha-positive 32D cells, DACi-mediated antiproliferative effects were associated with downregulation of BMI1 and c-MYC protein levels.	daci	49-53	RUNX1 translocation partner 1	Mus musculus	8-11
22895185-8	2012	In AML1/ETO or PLZF/RARalpha-positive 32D cells, DACi-mediated antiproliferative effects were associated with downregulation of BMI1 and c-MYC protein levels.	daci	49-53	zinc finger and BTB domain containing 16	Mus musculus	15-19
22895185-6	2012	We show that the self-renewal and short-term repopulation capacity of AML1/ETO- or PLZF/RARalpha-expressing Sca1+/lin- stem and progenitor cells are profoundly inhibited by clinically applicable concentrations of the DACi dacinostat and vorinostat.	daci	217-221	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	75-79
22895185-8	2012	In AML1/ETO or PLZF/RARalpha-positive 32D cells, DACi-mediated antiproliferative effects were associated with downregulation of BMI1 and c-MYC protein levels.	daci	49-53	retinoic acid receptor, alpha	Mus musculus	20-28
22895185-6	2012	We show that the self-renewal and short-term repopulation capacity of AML1/ETO- or PLZF/RARalpha-expressing Sca1+/lin- stem and progenitor cells are profoundly inhibited by clinically applicable concentrations of the DACi dacinostat and vorinostat.	daci	217-221	zinc finger and BTB domain containing 16	Homo sapiens	83-87
22895185-8	2012	In AML1/ETO or PLZF/RARalpha-positive 32D cells, DACi-mediated antiproliferative effects were associated with downregulation of BMI1 and c-MYC protein levels.	daci	49-53	Bmi1 polycomb ring finger oncogene	Mus musculus	128-132
22895185-6	2012	We show that the self-renewal and short-term repopulation capacity of AML1/ETO- or PLZF/RARalpha-expressing Sca1+/lin- stem and progenitor cells are profoundly inhibited by clinically applicable concentrations of the DACi dacinostat and vorinostat.	daci	217-221	retinoic acid receptor, alpha	Mus musculus	88-96
22895185-8	2012	In AML1/ETO or PLZF/RARalpha-positive 32D cells, DACi-mediated antiproliferative effects were associated with downregulation of BMI1 and c-MYC protein levels.	daci	49-53	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	137-142
22895185-7	2012	To further investigate the mechanisms underlying these effects, we examined the impact of DACi on the transcription factor c-MYC and the Polycomb group protein BMI1, which are induced by LAFP and involved in leukemic transformation.	daci	90-94	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	123-128
21153858-3	2010	As the acetylation status of histones has been linked to transcriptional regulation of genes involved particularly in differentiation and apoptosis, DAC inhibitors (DACi) have attracted considerable attention for treatment of hematologic malignancies.	daci	165-169	arylacetamide deacetylase	Homo sapiens	149-152