PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 3123227-3 1988 The thioether group of the methionine residue of GRF was converted in the sulfonium salt derivative, in order to prevent irreversible oxidation of methionine to the sulfone derivative by the o-iodosobenzoic acid reagent. Sulfides 4-13 growth hormone releasing hormone Homo sapiens 49-52 2730337-4 1989 In vitro testing of sulfide for inhibition of monoamine oxidase (MAO) activity showed the anion to be inhibitory with an IC50 of 39.1 +/- 3.6 microM. Sulfides 20-27 monoamine oxidase A Rattus norvegicus 46-63 2730337-4 1989 In vitro testing of sulfide for inhibition of monoamine oxidase (MAO) activity showed the anion to be inhibitory with an IC50 of 39.1 +/- 3.6 microM. Sulfides 20-27 monoamine oxidase A Rattus norvegicus 65-68 2730337-7 1989 Correlation of synaptosomal and mitochondrial sulfide levels with enzyme inhibition data suggests that inhibition of MAO may be an important contributing factor to the mechanism(s) underlying loss of central respiratory drive after fatal intoxication with H2S. Sulfides 46-53 monoamine oxidase A Rattus norvegicus 117-120 2848510-1 1988 A comparison of the binding properties of myoglobin and cytochrome c shows that the latter, in the reduced state, has an unusually large affinity for ligands, including thioethers. Sulfides 169-179 myoglobin Homo sapiens 42-51 2848510-1 1988 A comparison of the binding properties of myoglobin and cytochrome c shows that the latter, in the reduced state, has an unusually large affinity for ligands, including thioethers. Sulfides 169-179 cytochrome c, somatic Homo sapiens 56-68 2621572-4 1989 The thioether of succinimide afforded a 54% reduction of serum cholesterol and a 41% reduction of serum triglyceride levels in mice after 16 d. The alkyl thioethers of 1,8-naphthalimide and succinimide significantly lowered cholesterol levels in serum VLDL and LDL, while the alkyl thioethers of succinimide elevated HDL cholesterol content. Sulfides 4-13 CD320 antigen Mus musculus 252-256 2547720-6 1989 Myeloperoxidase in cell extract was, however, almost completely inhibited by 1 microM sulfide. Sulfides 86-93 myeloperoxidase Homo sapiens 0-15 2707318-4 1989 The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. Sulfides 4-13 cut-like homeobox 1 Mus musculus 41-44 2764678-6 1989 Our present theory is that maturation of Pep5 involves (a) enzymic conversion of Thr, Ser and Cys into dehydrated amino acids and sulfide bridges, (b) membrane translocation and cleavage of the modified prepeptide. Sulfides 130-137 VPS11 core subunit of CORVET and HOPS complexes Homo sapiens 41-45 2852666-7 1988 The sulphated mucopolysaccharides, chondroitin sulphate and mucin, strongly stimulated sulphide production in non-methanogenic faecal slurries only, suggesting that these substances may be a potential source of sulphate in the large gut. Sulfides 87-95 LOC100508689 Homo sapiens 60-65 3599095-0 1987 Urinary thioethers in workers exposed to the asphalt: an impairment of glutathione S-transferase activity? Sulfides 8-18 glutathione S-transferase kappa 1 Homo sapiens 71-96 3354230-2 1988 Both the cytochrome P-450-dependent mono-oxygenase system and the FAD-containing mono-oxygenase catalyse the sulphoxidation of thioether-containing organophosphate insecticides. Sulfides 127-136 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 9-25 3444374-6 1987 Thirty-five different natural and synthetic ether lipids and their metabolites (including a thioether) were tested as substrates for AGMO. Sulfides 92-101 alkylglycerol monooxygenase Rattus norvegicus 133-137 11542121-1 1987 Sulfide samples obtained from the U.S. Geological Survey"s DSRV Alvin dives on the southern Juan de Fuca Ridge closely resemble those from the same area described by Koski et al. Sulfides 0-7 alpha-L-fucosidase 1 Homo sapiens 100-104 3358522-0 1988 Determination of low sulphide and cyanide levels in biochemical and environmental control using a deposited-on-wire Ag-Ag2S electrode. Sulfides 21-29 angiotensin II receptor type 1 Homo sapiens 119-123 3028266-2 1987 The enzyme is a yellowish brown iron-sulfur protein, containing four nonheme iron and labile sulfide groups, that catalyzes the activation of NADP-malate dehydrogenase and fructose 1,6-bisphosphatase in the presence of ferredoxin and of thioredoxin m and f, respectively. Sulfides 93-100 fructose-1,6-bisphosphatase Zea mays 172-199 3028266-2 1987 The enzyme is a yellowish brown iron-sulfur protein, containing four nonheme iron and labile sulfide groups, that catalyzes the activation of NADP-malate dehydrogenase and fructose 1,6-bisphosphatase in the presence of ferredoxin and of thioredoxin m and f, respectively. Sulfides 93-100 LOC101027257 Zea mays 237-248 3694707-3 1987 SOD and catalase activities were most sensitive to sulfide (S2-), followed by sulfite (SO3(2-)) and sulfate (SO4(2-)). Sulfides 51-58 catalase Bos taurus 8-16 3002455-2 1986 Treatment of flavocytochrome c-552 with EDC was found to inhibit the sulfide: cytochrome c reductase activity of the enzyme. Sulfides 69-76 cytochrome c, somatic Equus caballus 18-30 3002455-4 1986 Both the inhibition of sulfide: cytochrome c reductase activity and the formation of the heme peptide dimer were decreased when the EDC modification was carried out in the presence of cytochrome c. Sulfides 23-30 cytochrome c, somatic Equus caballus 32-44 3002455-4 1986 Both the inhibition of sulfide: cytochrome c reductase activity and the formation of the heme peptide dimer were decreased when the EDC modification was carried out in the presence of cytochrome c. Sulfides 23-30 cytochrome c, somatic Equus caballus 184-196 3840372-1 1985 Mechanistic mode for the oxygenation of sulfides with the pig liver microsomal FAD-containing monooxygenase(EC 1.14.13.8) has been conveniently distinguished from that with the phenobarbital induced liver microsomal cytochrome P-450 by analyzing products of the oxygenation of phenacyl phenyl sulfide. Sulfides 40-48 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 216-232 3001047-3 1986 The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c. Sulfides 223-230 cytochrome c, somatic Equus caballus 30-42 3001047-3 1986 The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c. Sulfides 223-230 cytochrome c, somatic Equus caballus 56-68 3001047-3 1986 The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c. Sulfides 223-230 cytochrome c, somatic Equus caballus 56-68 3001047-3 1986 The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c. Sulfides 223-230 cytochrome c, somatic Equus caballus 56-68 3840372-3 1985 The observation suggests that the oxygenation of sulfide with FAD-containing monooxygenase involves the nucleophilic attack of the divalent sulfur on the reactive oxygen atom involved at the enzyme active site, namely electrophilic oxygenation of sulfide, though the oxygenation with the cytochrome P-450 is initiated by a single electron transfer from the sulfide to the enzyme active species. Sulfides 49-56 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 288-304 3840372-3 1985 The observation suggests that the oxygenation of sulfide with FAD-containing monooxygenase involves the nucleophilic attack of the divalent sulfur on the reactive oxygen atom involved at the enzyme active site, namely electrophilic oxygenation of sulfide, though the oxygenation with the cytochrome P-450 is initiated by a single electron transfer from the sulfide to the enzyme active species. Sulfides 247-254 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 288-304 3840372-3 1985 The observation suggests that the oxygenation of sulfide with FAD-containing monooxygenase involves the nucleophilic attack of the divalent sulfur on the reactive oxygen atom involved at the enzyme active site, namely electrophilic oxygenation of sulfide, though the oxygenation with the cytochrome P-450 is initiated by a single electron transfer from the sulfide to the enzyme active species. Sulfides 247-254 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 288-304 4023466-4 1985 The rechromatographic studies under conditions of protein denaturation and sulfide cleavage on Sepharose CL-6B column revealed that the peak 1 of the pregnant women and patients with pituitary adenoma were eluted at the position between 125I-AFP and ovalbumine and the molecular weight was estimated to be about 54,000. Sulfides 75-82 pseudopodium enriched atypical kinase 1 Homo sapiens 136-142 6491941-1 1984 Catechol derivatives, covalently joined to homocysteine by sulfide or sulfonium linkages, were synthesized as potential catechol O-methyltransferase multisubstrate inhibitors which might bridge the enzymatic binding sites for the catechol substrate and the amino acid portion of the methyl donor S-adenosylmethionine. Sulfides 59-66 catechol-O-methyltransferase Homo sapiens 120-148 3921273-0 1985 Formation of thioether conjugates of the bladder carcinogen ANFT catalyzed by prostaglandin H synthase. Sulfides 13-22 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 78-102 6995455-3 1980 This thioether-containing structural analogue of acetyl-CoA is a potent competitive inhibitor, with respect to acetyl-CoA, of citrate synthase, phosphotransacetylase, and carnitine acetyltransferase. Sulfides 5-14 citrate synthase Rattus norvegicus 126-142 6477350-1 1984 Conjugates of the monoclonal antibody anti-Thy 1:1 (OX7) and ricin have been constructed, using a thioether bond, such that the ricin no longer can bind Sepharose or asialofetuin. Sulfides 98-107 thymus cell antigen 1, theta Mus musculus 43-50 6402020-6 1983 Rhodanese-mediated sulfide transfer was directly demonstrated when the reactivation of NADH dehydrogenase was performed in the presence of radioactive thiosulfate (labeled in the outer sulfur) and the 35S-loaded flavoprotein was re-isolated by gel filtration chromatography. Sulfides 19-26 thiosulfate sulfurtransferase Bos taurus 0-9 6874088-1 1983 The urinary excretion of thioethers was studied among smokers of medium-tar cigarettes (16.3 mg/cig.) Sulfides 25-35 fibronectin 1 Homo sapiens 76-79 6282878-2 1982 The binding of thiol, thiolate, thioether, and disulfide sulfur donor ligands to ferric cytochrome P-450-CAM and myoglobin has been investigated by UV-visible absorption, magnetic circular dichroism (MCD), and EPR spectroscopy. Sulfides 32-41 myoglobin Homo sapiens 88-122 7093200-4 1982 In addition, PB-1-1 catalyzed oxygen transfer to the p-methyl group of the sulfide substrates to yield the (ethylthio)benzyl alcohol with a turnover of 6.8 min-1, corresponding to a sulfur:carbon oxygenation partition ratio of 6:1. Sulfides 75-82 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 Rattus norvegicus 13-19 6278020-8 1982 We suggest that myeloperoxidase-catalyzed oxidation of thioethers may constitute an inflammatory control mechanism as well as a general means of modifying the functional properties of biologic mediators. Sulfides 55-65 myeloperoxidase Homo sapiens 16-31 6267057-6 1981 These findings indicate that secretion of myeloperoxidase and hydrogen peroxide by activated granulocytes results in decreased fluorescence of 3,3"-dipropylthiodicarbocyanine, probably by thioether oxidation. Sulfides 188-197 myeloperoxidase Homo sapiens 42-57 6106162-2 1980 The structure of SRS from a mouse mastocytoma and rat basophilic leukaemia (RBL-1) cells has been identified as a thioether or arachidonic acid and glutathione [not a thioether of cystene as was originally thought]. Sulfides 114-123 RB transcriptional corepressor like 1 Rattus norvegicus 76-81 6968914-4 1980 The antibody-ricin hybrid protein, anti-Thy 1.2-ricin, formed with a thioether linkage, has been purified by size exclusion and affinity chromatography. Sulfides 69-78 thymus cell antigen 1, theta Mus musculus 40-47 6428412-12 1984 However, the PCB-pretreated rats excreted less thioethers (62%) compared to the rats treated only with the same amount of vinyltoluene whereas the total sum of the other metabolites was about the same in these both groups. Sulfides 47-57 pyruvate carboxylase Rattus norvegicus 13-16 6288202-0 1982 Sulphide as an inhibitor and electron donor for the cytochrome c oxidase system. Sulfides 0-8 cytochrome c, somatic Homo sapiens 52-64 6288202-1 1982 Anomalies both kinetic and equilibrium in nature are described for the inhibition of cytochrome c oxidase activity by sulphide in the isolated enzyme and in submitochondrial particles. Sulfides 118-126 cytochrome c, somatic Homo sapiens 85-97 7315740-2 1981 Interlocking O2 absorption and sulfide depletion data indicate that both oxyhemoglobin and methemoglobin are effective catalytic agents. Sulfides 31-38 hemoglobin subunit gamma 2 Homo sapiens 91-104 6796536-6 1981 Thioether 2 and sulfoxide 3-R exert 50% inhibition of RNA polymerase II (or B) from Drosophila melanogaster in 10(-6) M solution whereas Ki of 3-S is about five times higher. Sulfides 0-9 oo18 RNA-binding protein Drosophila melanogaster 73-77 6995455-3 1980 This thioether-containing structural analogue of acetyl-CoA is a potent competitive inhibitor, with respect to acetyl-CoA, of citrate synthase, phosphotransacetylase, and carnitine acetyltransferase. Sulfides 5-14 carnitine O-acetyltransferase Rattus norvegicus 171-198 18962718-2 1980 Sulphide ores, e.g., galena, sphalerite, are quantitatively decomposed with CPA alone to give hydrogen sulphide. Sulfides 0-8 carboxypeptidase A1 Homo sapiens 76-79 86549-10 1979 Timm"s sulfide silver preparations indicate that the characteristic staining patterns seen in the dentate gyrus and hippocampus appear at the same time, and mature at the same rate in normal and reeler mice. Sulfides 7-14 reelin Mus musculus 195-201 41240-4 1979 This amino acid was attached in thioether linkage at C-6. Sulfides 32-41 complement component 6 Mus musculus 53-56 490537-1 1979 One-step treatment of daunomycinone with excess 2-aminoethanethiol and 2-aminoethanol in trifluoroacetic acid afforded at C-7 the thioether (77% yield) and ether (30% after recycling), respectively. Sulfides 130-139 complement C7 Homo sapiens 122-125 222744-3 1979 Cytochrome c-552 has a sulfide-cytochrome c reductase activity and also catalyzes the reduction of elementary sulfur to sulfide with reduced benzylviologen as the electron donor. Sulfides 23-30 cytochrome c, somatic Homo sapiens 0-12 222744-3 1979 Cytochrome c-552 has a sulfide-cytochrome c reductase activity and also catalyzes the reduction of elementary sulfur to sulfide with reduced benzylviologen as the electron donor. Sulfides 23-30 cytochrome c, somatic Homo sapiens 31-43 202316-6 1978 EPR spectra of the azide, sulfide and formate complexes of cytochrome c oxidase in mitochondria in situ obtained as a function of the orientation of the applied magnetic field relative to the planes of the membrane multilayers showed that both hemes of the oxidase were oriented in such a way that the angle between the heme normal and the membrane normal was approx. Sulfides 26-33 cytochrome c, somatic Homo sapiens 59-71 22333-0 1977 The effect of methemoglobin on the inhibition of cytochrome c oxidase by cyanide, sulfide or azide. Sulfides 82-89 hemoglobin subunit gamma 2 Homo sapiens 14-27 1204657-0 1975 Ligand binding of organic sulfides to microsomal cytochrome P-450. Sulfides 26-34 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 49-65 986188-2 1976 This reagent, in the absence of thiosulfate, reduces the amount of sulfur carried by rhodanese with formation of sulfide and oxidized dithiothreitol: E-S-SH + reduced dithiothreitol replaced by E-SH + HS- + oxidized dithiothreitol, (E = enzyme). Sulfides 113-120 thiosulfate sulfurtransferase Bos taurus 85-94 194892-0 1977 Evidence for a thioether linkage between the flavin and polypeptide chain of Chromatium cytochrome c 552. Sulfides 15-24 cytochrome c, somatic Homo sapiens 88-100 194900-3 1977 At low concentrations of NCS/urea the oxidation of thioether side chains in cytochrome c is the predominant reaction. Sulfides 51-60 cytochrome c, somatic Equus caballus 76-88 1204657-4 1975 These results indicate a direct ligand binding of the sulfides to cytochrome P-450 with concomitant blocking of the hydrophobic substrate binding site. Sulfides 54-62 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-82 5015871-0 1972 [Efficacy of sulfide baths of the Donetsk mineral spa in the complex therapy of psorisis]. Sulfides 13-20 surfactant protein A2 Homo sapiens 50-53 1156453-0 1975 Effects of the tumor inhibitor, vernolepin, and of its thioether adduct, on the activity of catechol O-methyltransferase in vitro. Sulfides 55-64 catechol-O-methyltransferase Homo sapiens 92-120 11946420-0 1972 Photooxidation of the thioether bridges of horse heart cytochrome C. Sulfides 22-31 cytochrome c, somatic Equus caballus 55-67 4361686-5 1973 On the other hand, since residue 13 is immediately above the edge of the heme that is at the "front surface" of the molecule, we suggest that the electron leaves ferrocytochrome c to cytochrome c oxidase by way of the edge of pyrrole ring II or the adjacent surface-located sulfur of cysteinyl residue 17, which is thioether bonded to the heme. Sulfides 315-324 cytochrome c, somatic Equus caballus 167-179 5104187-0 1971 Chemical modification of the thioether bridges in cytochrome c. Sulfides 29-38 cytochrome c, somatic Homo sapiens 50-62 6033636-0 1967 The oxygen and sulfide binding characteristics of hemoglobins generated from methemoglobin by two erythrocytic systems. Sulfides 15-22 hemoglobin subunit gamma 2 Homo sapiens 77-90 5342428-0 1967 The use of silver for intensifying sulfide deposits in the cholinesterase technique. Sulfides 35-42 butyrylcholinesterase Homo sapiens 59-73 33910746-2 2021 The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB). Sulfides 57-67 mitochondrially encoded cytochrome c oxidase II Homo sapiens 156-163 5921892-0 1966 On the mechanism of sulfide inactivation by methemoglobin. Sulfides 20-27 hemoglobin subunit gamma 2 Homo sapiens 44-57 16576217-0 1917 New Data on the Phosphorescence of Certain Sulphides: (Discussing Measurements by Drs. Sulfides 43-52 sushi repeat containing protein X-linked Homo sapiens 82-85 13168390-0 1954 Sulfide inhibition of catalase. Sulfides 0-7 catalase Homo sapiens 22-30 33983027-4 2021 Oxygen-18 labeling experiments with either 18O-labeled 1 or 18O-labeled H2O2 are consistent with a sulfide oxygenation pathway that uses a eta1-Mo(OOH) hydroxoperoxyl species (3). Sulfides 99-106 secreted phosphoprotein 1 Homo sapiens 139-143 33975948-5 2021 We demonstrate that sulfide regulates ATG18a phospholipid-binding activity by reversible persulfidation at Cys103, and that this modification activates ATG18a binding capacity to specific phospholipids in a reversible manner. Sulfides 20-27 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 38-44 33826216-3 2021 Exposed to soft Lewis donors, Si(OTf)4 leads to [L2Si(OTf)4] complexes (L = isocyanide, thioether and carbonyl compounds) with retention of all Si-OTf bonds. Sulfides 88-97 POC1 centriolar protein A Homo sapiens 11-15 33826216-3 2021 Exposed to soft Lewis donors, Si(OTf)4 leads to [L2Si(OTf)4] complexes (L = isocyanide, thioether and carbonyl compounds) with retention of all Si-OTf bonds. Sulfides 88-97 POU class 5 homeobox 1 Homo sapiens 30-38 33826216-3 2021 Exposed to soft Lewis donors, Si(OTf)4 leads to [L2Si(OTf)4] complexes (L = isocyanide, thioether and carbonyl compounds) with retention of all Si-OTf bonds. Sulfides 88-97 POU class 5 homeobox 1 Homo sapiens 49-59 33933447-9 2021 Knockdown of sulfide quinone oxidoreductase, which commits H2S to oxidation, sensitized cells to sulfide-stimulated aerobic glycolysis. Sulfides 13-20 crystallin zeta Homo sapiens 21-43 33949420-2 2021 This work reports the "thiolene" click immobilization of heptakis(6-mercapto-6-deoxy)-beta-CD-CSP onto alkene functional silica to afford novel multiple-thioether bridged CD CSPs by controlling the surface CD concentration. Sulfides 153-162 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 86-93 33947751-1 2021 In eukaryotes, heme attachment through two thioether bonds to mitochondrial cytochromes c and c 1 is catalyzed by either multisubunit cytochrome c maturation system I or holocytochrome c synthetase (HCCS). Sulfides 43-52 cytochrome c, somatic Homo sapiens 134-146 33947751-1 2021 In eukaryotes, heme attachment through two thioether bonds to mitochondrial cytochromes c and c 1 is catalyzed by either multisubunit cytochrome c maturation system I or holocytochrome c synthetase (HCCS). Sulfides 43-52 holocytochrome c synthase Homo sapiens 170-197 33947751-1 2021 In eukaryotes, heme attachment through two thioether bonds to mitochondrial cytochromes c and c 1 is catalyzed by either multisubunit cytochrome c maturation system I or holocytochrome c synthetase (HCCS). Sulfides 43-52 holocytochrome c synthase Homo sapiens 199-203 33080111-3 2021 To prevent respiratory poisoning, a dedicated set of enzymes comprising the mitochondrial sulfide oxidation pathway exists to clear H 2 S. The committed step in this pathway is catalyzed by sulfide quinone oxidoreductase (SQOR), which couples sulfide oxidation to coenzyme Q 10 reduction in the electron transport chain. Sulfides 90-97 crystallin zeta Homo sapiens 198-220 33894438-5 2021 Two fluorescent probes (4-mercaptocoumarins, ArSH) in ethanol deprotonate to form thiophenol anions (ArS-) resulting from their low pKa values (3.2-3.4), and the nucleophilic addition of the anion ArS- generates the corresponding thioethers, giving a turn-on fluorescence response. Sulfides 230-240 arylsulfatase family member H Homo sapiens 45-49 33894438-5 2021 Two fluorescent probes (4-mercaptocoumarins, ArSH) in ethanol deprotonate to form thiophenol anions (ArS-) resulting from their low pKa values (3.2-3.4), and the nucleophilic addition of the anion ArS- generates the corresponding thioethers, giving a turn-on fluorescence response. Sulfides 230-240 RIEG2 Homo sapiens 45-48 33894438-5 2021 Two fluorescent probes (4-mercaptocoumarins, ArSH) in ethanol deprotonate to form thiophenol anions (ArS-) resulting from their low pKa values (3.2-3.4), and the nucleophilic addition of the anion ArS- generates the corresponding thioethers, giving a turn-on fluorescence response. Sulfides 230-240 RIEG2 Homo sapiens 101-104 33465268-3 2021 In this work, a series of thioether-bridged angucyclines were discovered, and a cryptic epoxide Michael acceptor intermediate was revealed en route to thioangucyclines (TACs) A and B. Sulfides 26-35 cripto, FRL-1, cryptic family 1 Homo sapiens 80-87 33080111-3 2021 To prevent respiratory poisoning, a dedicated set of enzymes comprising the mitochondrial sulfide oxidation pathway exists to clear H 2 S. The committed step in this pathway is catalyzed by sulfide quinone oxidoreductase (SQOR), which couples sulfide oxidation to coenzyme Q 10 reduction in the electron transport chain. Sulfides 90-97 sulfide quinone oxidoreductase Homo sapiens 222-226 33080111-3 2021 To prevent respiratory poisoning, a dedicated set of enzymes comprising the mitochondrial sulfide oxidation pathway exists to clear H 2 S. The committed step in this pathway is catalyzed by sulfide quinone oxidoreductase (SQOR), which couples sulfide oxidation to coenzyme Q 10 reduction in the electron transport chain. Sulfides 190-197 crystallin zeta Homo sapiens 198-220 33080111-3 2021 To prevent respiratory poisoning, a dedicated set of enzymes comprising the mitochondrial sulfide oxidation pathway exists to clear H 2 S. The committed step in this pathway is catalyzed by sulfide quinone oxidoreductase (SQOR), which couples sulfide oxidation to coenzyme Q 10 reduction in the electron transport chain. Sulfides 190-197 sulfide quinone oxidoreductase Homo sapiens 222-226 33080111-5 2021 Here, we review the kinetic and structural characteristics of human SQOR, and how its unconventional redox cofactor configuration and substrate promiscuity lead to sulfide clearance and potentially expand the signaling potential of H 2 S. This dual role of SQOR makes it a promising target for H 2 S-based therapeutics. Sulfides 164-171 sulfide quinone oxidoreductase Homo sapiens 68-72 33080111-5 2021 Here, we review the kinetic and structural characteristics of human SQOR, and how its unconventional redox cofactor configuration and substrate promiscuity lead to sulfide clearance and potentially expand the signaling potential of H 2 S. This dual role of SQOR makes it a promising target for H 2 S-based therapeutics. Sulfides 164-171 sulfide quinone oxidoreductase Homo sapiens 257-261 33221138-1 2021 In this study, we proposed a novel method for the determination of nanomolar dissolved sulfides, including H2S, HS-, and S2- (defined as S(-II)) in water by coupling the classical methylene blue (MB) method with surface-enhanced Raman spectroscopy (SERS) detection. Sulfides 87-95 transcription elongation factor A1 Homo sapiens 137-143 33469157-5 2021 Mechanistic study reveals that photoexcited flavins covalently bind cysteine residues in Orai1 via thioether bonds, which facilitates Orai1 polymerization to form store-operated calcium channels (SOCs) independently of STIM1, a protein generally participating in SOC formation, enabling all-optical activation of Ca2+ influx and downstream signaling pathways. Sulfides 99-108 ORAI calcium release-activated calcium modulator 1 Mus musculus 89-94 33446066-1 2021 Employing ultraviolet light to enhance the removal of As(V) by sulfide (S(-II)) from strongly acidic wastewater is a potential method. Sulfides 63-70 transcription elongation factor A1 Homo sapiens 72-78 33586294-8 2021 Encouraged by the stimulated reversibility of Sb2 S3 and SnS2 anodes, other sulfides with high electrochemical performance also could be developed for KIBs. Sulfides 76-84 sodium voltage-gated channel alpha subunit 11 Homo sapiens 57-61 33469157-5 2021 Mechanistic study reveals that photoexcited flavins covalently bind cysteine residues in Orai1 via thioether bonds, which facilitates Orai1 polymerization to form store-operated calcium channels (SOCs) independently of STIM1, a protein generally participating in SOC formation, enabling all-optical activation of Ca2+ influx and downstream signaling pathways. Sulfides 99-108 ORAI calcium release-activated calcium modulator 1 Mus musculus 134-139 33310503-6 2021 Consistent with an important role for H2S in AF, CSE-KO mice had decreased atrial sulfide levels, increased atrial superoxide levels, and enhanced propensity for induced persistent AF compared to wild type (WT) mice. Sulfides 82-89 cystathionase (cystathionine gamma-lyase) Mus musculus 49-52 33276950-3 2021 We identified a novel TNFalpha-binding thioether-cyclized peptide that contains an N-methyl-d-phenylalanine. Sulfides 39-48 tumor necrosis factor Homo sapiens 22-30 32771742-4 2021 More interestingly, the EC and PEC responses of the functionalized electrodes are proportionately decreased in response to the generation of Bi2S3 and Ag2S nanoparticles upon exposure to sulfide ions. Sulfides 187-194 angiotensin II receptor type 1 Homo sapiens 151-155 33310503-7 2021 Rescuing H2S signaling in CSE-KO mice by Diallyl trisulfide (DATS) supplementation or reconstitution with endothelial cell specific CSE over-expression significantly reduced atrial superoxide, increased sulfide levels, and lowered AF inducibility. Sulfides 52-59 cystathionase (cystathionine gamma-lyase) Mus musculus 26-29 33205994-0 2020 Red Blood Cells as a "Central Hub" for Sulfide Bioactivity: Scavenging, Metabolism, Transport, and Cross-Talk with Nitric Oxide. Sulfides 39-46 bone morphogenetic protein receptor type 2 Homo sapiens 105-109 32975579-4 2020 This finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the first enzyme in the sulfide oxidation pathway. Sulfides 210-217 crystallin zeta Homo sapiens 218-240 33037147-0 2020 Abscisic Acid-Triggered Persulfidation of Cysteine Protease ATG4 Mediates Regulation of Autophagy by Sulfide. Sulfides 101-108 UbiA prenyltransferase family protein Arabidopsis thaliana 60-64 33037147-7 2020 The biological significance of the reversible inhibition of the ATG4 by sulfide is supported by the results obtained in Arabidopsis leaves under basal and autophagy-activating conditions. Sulfides 72-79 UbiA prenyltransferase family protein Arabidopsis thaliana 64-68 33037147-8 2020 A significant increase in the overall ATG4 proteolytic activity in Arabidopsis was detected under nitrogen starvation and osmotic stress and can be inhibited by sulfide. Sulfides 161-168 UbiA prenyltransferase family protein Arabidopsis thaliana 38-42 33037147-9 2020 Therefore, the data strongly suggest that the negative regulation of autophagy by sulfide is mediated by specific persulfidation of the ATG4 protease. Sulfides 82-89 UbiA prenyltransferase family protein Arabidopsis thaliana 136-140 32975579-6 2020 This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system. Sulfides 241-248 cystathionine gamma-lyase Homo sapiens 88-113 32975579-4 2020 This finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the first enzyme in the sulfide oxidation pathway. Sulfides 210-217 sulfide quinone oxidoreductase Homo sapiens 242-246 32975579-4 2020 This finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the first enzyme in the sulfide oxidation pathway. Sulfides 273-280 crystallin zeta Homo sapiens 218-240 32975579-4 2020 This finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the first enzyme in the sulfide oxidation pathway. Sulfides 273-280 sulfide quinone oxidoreductase Homo sapiens 242-246 32975579-6 2020 This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system. Sulfides 241-248 sulfide quinone oxidoreductase Homo sapiens 17-21 32975579-6 2020 This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system. Sulfides 241-248 cystathionine beta-synthase Homo sapiens 56-83 33146649-0 2020 Tuning Rh(II)-catalysed cyclopropanation with tethered thioether ligands. Sulfides 55-64 Rh blood group D antigen Homo sapiens 7-13 33146649-2 2020 In this study, we report our efforts to use tethered thioether ligands to tune the reactivity of RhII-carbene mediated cyclopropanation of olefins with ethyl diazoacetate. Sulfides 53-62 Rh blood group D antigen Homo sapiens 97-101 33146649-3 2020 Microwave methods enabled the synthesis of a family of RhII complexes in which tethered thioether moieties were coordinated to axial sites of the complex. Sulfides 88-97 Rh blood group D antigen Homo sapiens 55-59 32569010-4 2020 MATERIALS AND METHODS: We recombinantly expressed the Thy1-scFv with a carboxy-terminus cysteine residue to facilitate its thioether conjugation to the PEGylated MBs presenting with maleimide functional groups. Sulfides 123-132 Thy-1 cell surface antigen Homo sapiens 54-58 32871376-3 2020 The method involves the derivatization of sulfide with pyrylium salts - (2,4,6-triphenylpyrylium hydrogensulfate(VI) (L1) and 4-[p-(N,N-dimethylamino)phenyl]-2,6-diphenylpyrylium chlorate(VII) (LN1). Sulfides 42-49 phytanoyl-CoA 2-hydroxylase Homo sapiens 194-197 32569010-4 2020 MATERIALS AND METHODS: We recombinantly expressed the Thy1-scFv with a carboxy-terminus cysteine residue to facilitate its thioether conjugation to the PEGylated MBs presenting with maleimide functional groups. Sulfides 123-132 immunglobulin heavy chain variable region Homo sapiens 59-63 33083227-2 2020 In this work, we investigate MET25, a locus encoding sulfide housekeeping gene within the cell, to be exploited as a standard genetic marker. Sulfides 53-60 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Saccharomyces cerevisiae S288C 29-34 32822167-3 2020 Herein, we report a silicon-doped solid electrolyte Li6+xP1-xSixS5I in this sulfide class, which can remarkably increase the conductivity to 1.1 x 10-3 S cm-1 and lower the activation energy to 0.19 eV as a consequence of changing the structural unit in the argyrodite network. Sulfides 76-83 XPA, DNA damage recognition and repair factor Homo sapiens 56-59 32160317-0 2020 Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease. Sulfides 37-44 sulfide quinone oxidoreductase Homo sapiens 23-27 32782510-3 2020 The multifunctional, targeted, polymeric nanoparticles were prepared using a double emulsion method and chemokine SDF-1 was conjugated to nanoparticles by a sulfide bond. Sulfides 157-164 C-X-C motif chemokine ligand 12 Homo sapiens 114-119 32667728-2 2020 The cleaved molecules are sequestered by the metal centre and the pincer alkylidene linkage, forming eta 2 -coordinated sulfide or imide centred pincer complexes. Sulfides 120-127 DNA polymerase iota Homo sapiens 101-106 32160317-0 2020 Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease. Sulfides 37-44 crystallin zeta Homo sapiens 45-67 32160317-1 2020 PURPOSE: Hydrogen sulfide, a signaling molecule formed mainly from cysteine, is catabolized by sulfide:quinone oxidoreductase (gene SQOR). Sulfides 18-25 crystallin zeta Homo sapiens 103-125 32160317-1 2020 PURPOSE: Hydrogen sulfide, a signaling molecule formed mainly from cysteine, is catabolized by sulfide:quinone oxidoreductase (gene SQOR). Sulfides 18-25 sulfide quinone oxidoreductase Homo sapiens 132-136 32787249-1 2020 Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in sulfide clearance, coupling H2S oxidation to coenzyme Q reduction. Sulfides 66-73 crystallin zeta Homo sapiens 8-30 32531495-0 2020 Pin-point denitrification for groundwater purification without direct chemical dosing: Demonstration of a two-chamber sulfide-driven denitrifying microbial electrochemical system. Sulfides 118-125 dynein light chain LC8-type 1 Homo sapiens 0-3 32787249-1 2020 Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in sulfide clearance, coupling H2S oxidation to coenzyme Q reduction. Sulfides 66-73 sulfide quinone oxidoreductase Homo sapiens 32-36 32787249-5 2020 We captured a disulfanyl-methanimido thioate intermediate in the SQOR crystal structure, revealing how cyanolysis leads to reversible loss of SQOR activity that is restored in the presence of sulfide. Sulfides 192-199 sulfide quinone oxidoreductase Homo sapiens 65-69 32787249-5 2020 We captured a disulfanyl-methanimido thioate intermediate in the SQOR crystal structure, revealing how cyanolysis leads to reversible loss of SQOR activity that is restored in the presence of sulfide. Sulfides 192-199 sulfide quinone oxidoreductase Homo sapiens 142-146 32700706-3 2020 The Sn(iv)-metalated COF material Sn-CPF-3 exhibits high photocatalytic efficiency and selectivity in aerobic oxidation of sulfides to produce highly value-added sulfoxides with up to 23 334 turnovers and 648 h-1 turnover frequency under visible light irradiation. Sulfides 123-131 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-42 32503840-8 2020 The ternary structure of SETD3 in complex with the methionine-containing actin peptide at 1.9 A resolution revealed that the hydrophobic thioether side chain is packed by the aromatic rings of Tyr312 and Trp273 as well as the hydrocarbon side chain of Ile310. Sulfides 137-146 SET domain containing 3, actin histidine methyltransferase Homo sapiens 25-30 32687320-6 2020 In sulfide-based all-solid-state batteries with Li metal as the anode, this cathode composite delivered a high capacity of 1025 mAh g-1 after 50 cycles at 60 oC at 1/8 C. This work highlights the important role of high and balanced electronic and ionic conductivities in developing high-performance sulfur cathodes for ASSLSBs. Sulfides 3-10 angiotensin II receptor type 1 Homo sapiens 161-167 32944145-1 2020 Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of 1 and 2 led to the identification of aryl ether and thioether-derived bicyclic S1P1 differentiated modulators 3-6. Sulfides 142-151 sphingosine-1-phosphate receptor 1 Homo sapiens 169-173 32832763-2 2020 Analyses of the total and partial density of states (DOS), with electron density and differential charge density, show that Cu-S and Ni-S bonds are of covalent character, and as the ratio of Ni/Cu to S decreases for the sulfides, Cu/Ni-3d orbital energies shift downward, while S-3p orbital energies shift upward. Sulfides 220-228 solute carrier family 5 member 5 Homo sapiens 133-137 32617543-9 2020 The analysis of the quaternary X-Ag-As-S (X = cations) system shows that various combination ways of Ag-S and As-S ABUs in these sulfides can be attributed to the cation-cation repulsion and stereochemically active lone-pair effect. Sulfides 129-137 jagged canonical Notch ligand 1 Homo sapiens 101-105 32628440-0 2020 MOF-Derived Sulfide-Based Electrocatalyst and Scaffold for Boosted Hydrogen Production. Sulfides 12-19 lysine acetyltransferase 8 Homo sapiens 0-3 32627911-2 2020 A bidirectional catalyst design, oxide-sulfide heterostructure, is proposed to accelerate both reduction of soluble polysulfides and oxidation of insoluble discharge products (e.g., Li2 S), indicating a fundamental way for improving both the cycling stability and sulfur utilization. Sulfides 39-46 ATP binding cassette subfamily A member 12 Homo sapiens 182-185 32330361-4 2020 AspH inhibition was assayed using a mass spectrometry based assay employing a stable thioether-analogue of a natural EGFD AspH substrate. Sulfides 85-94 aspartate beta-hydroxylase Homo sapiens 0-4 32124508-3 2020 We investigated the effects of sulphide on the partitioning of NO3 - between complete denitrification and DNRA and the microbial communities in salt marsh sediments. Sulfides 31-39 NBL1, DAN family BMP antagonist Homo sapiens 63-66 32482849-3 2020 Sulfides in the former preserve evidence of mass-independent fractionation of sulfur isotopes (S-MIF) falling within uncertainty of the Archean reference array with a 36S/ 33S slope of -1.8 and have small negative 33S values, whereas in the latter mass-dependent fractionation of sulfur isotopes (S-MDF) is evident, with a 36S/ 33S slope of -8.8. Sulfides 0-8 macrophage migration inhibitory factor Homo sapiens 97-100 32135291-9 2020 The sulfide oxidation causing increased SO42- was reflected by the blooming of sulfur-oxidizing microbes and soxB gene. Sulfides 4-11 SRY-box transcription factor 3 Homo sapiens 109-113 32930176-1 2020 In this paper, a novel high flexibility all-solid contact ion selective electrode (ASC-ISE) based on reduced graphene sheets (RGSs) as the ion-to-electron transducer was developed for rapid detection of sulfide. Sulfides 203-210 steroid sulfatase Homo sapiens 83-86 32930176-4 2020 The evaluation of the analytical performances, such as the linear range, selectivity, stability, and practical application, of the proposed ASC-ISEs for the rapid detection of sulfide was performed. Sulfides 176-183 steroid sulfatase Homo sapiens 140-143 32930176-5 2020 The results showed that, the ASC-ISEs exhibited a linear relationship between the obtained potential signal and sulfide concentration in the range of 0.50 muM to 1.0 mM, with a detection limit of 0.18 muM. Sulfides 112-119 steroid sulfatase Homo sapiens 29-32 32930176-6 2020 Moreover, the ASC-ISEs showed good selectivity towards sulfide over other common interfering ions, and maintained a stable electrochemical response over 7 days. Sulfides 55-62 steroid sulfatase Homo sapiens 14-17 32930176-7 2020 These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications. Sulfides 141-148 steroid sulfatase Homo sapiens 128-131 32930176-7 2020 These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications. Sulfides 141-148 steroid sulfatase Homo sapiens 252-255 32124508-4 2020 Complete denitrification significantly decreased with increasing sulphide, resulting in an increase in the contribution of DNRA to NO3 - respiration. Sulfides 65-73 NBL1, DAN family BMP antagonist Homo sapiens 131-134 32124508-5 2020 Alternative fates of NO3 - became increasingly important at higher sulphide treatments, which could include N2 O production and/or transport into intracellular vacuoles. Sulfides 67-75 NBL1, DAN family BMP antagonist Homo sapiens 21-24 32182483-2 2020 A critical elimination capacity (EC) of 251.93 g S m-3 h-1 was obtained for the BTF/BF system during a stepwise increase of sulfide concentration from 10 to 60 g S m-3. Sulfides 124-131 BCL2 associated transcription factor 1 Homo sapiens 80-86 32670761-5 2020 By incorporating GO sheets in a nanocomposite of copper-cuprous oxide-GO (Cu-Cu2O-GO, CCG), a composite Li anode enables a high coulombic efficiency above 99.5% over 120 cycles for an SSB using Li10GeP2S12 SSE and LiCoO2 cathode, and the sulfide SSE is not chemically decomposed after cycling. Sulfides 238-245 small RNA binding exonuclease protection factor La Homo sapiens 184-187 32259435-6 2020 The positively charged surface of AgNWs in the presence of LYZ favored the access of sulfide ions. Sulfides 85-92 lysozyme Homo sapiens 59-62 31846946-2 2020 Here, we synthesized an efficient HER electrocatalyst of amorphous ruthenium sulfide (A-RuS2), exhibiting an overpotential of 141 mV at the current density of 10 mA cm-2 and a Tafel slope of 65.6 mV dec-1. Sulfides 67-84 deleted in esophageal cancer 1 Homo sapiens 199-204 34054136-8 2020 These findings and SO4 2- concentrations >=20 mg/L in three-quarters of the sampled wells suggest that high levels of NO3 -, presumably from extensive fertilizer application, may have triggered the release of As by oxidizing sulfide-bound As supplied by erosion of black shale and slate in the Himalayas. Sulfides 225-232 NBL1, DAN family BMP antagonist Homo sapiens 118-121 32167273-5 2020 Herein, we present the performance of a Li-rich layered sulfide of formula Li1.13Ti0.57Fe0.3S2 (LTFS) in room temperature operating all-solid-state batteries, using beta-Li3PS4 as SE and both InLi and Li anode materials. Sulfides 56-63 transglutaminase 1 Homo sapiens 75-78 31877476-8 2020 The sulfide concentration in the experimental sewer effluent decreased by 3.5 +- 0.2 mgS L-1 as compared with the control, while the phosphate concentration decreased by 3.6 +- 0.3 mgP L-1 after biological wastewater treatment in the experimental SBR. Sulfides 4-11 immunoglobulin kappa variable 1-16 Homo sapiens 89-92 31877476-9 2020 The dissolved sulfide concentration in the experimental anaerobic digester also decreased by 15.9 +- 0.9 mgS L-1 following the DWS-dosing to the sewer reactors. Sulfides 14-21 immunoglobulin kappa variable 1-16 Homo sapiens 109-112 31995982-2 2020 Here we reported a hard template engaged cation exchange method to fabricate a family of binary or ternary metal sulfide (CuS, Ag2S, Bi2S3, CuxBi1-xS, ZnxCo1-xS, ZnxCd1-xS, ZnxNi1-xS and ZnxMn1-xS) hollow microspheres via adjusting the reaction kinetic parameters including solvent, temperature in presence of unique ZnS composite microspheres. Sulfides 113-120 angiotensin II receptor type 1 Homo sapiens 127-131 31944103-4 2020 Because of the porous structure of ZIF and the high intrinsic activity of the bimetallic sulfide nanoparticles, the Co9-xNixS8/NC catalyst exhibits high half-wave potential 0.86 V vs. RHE for ORR and outstanding bifunctional catalytic performance. Sulfides 89-96 phosphoserine phosphatase pseudogene 1 Homo sapiens 116-119 32011125-0 2020 Unusually Distorted Pseudo-Octahedral Coordination Environment Around CoII from Thioether Schiff Base Ligands in Dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) Complexes: Synthesis, Structure, and Understanding of Magnetic Behavior. Sulfides 80-96 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-74 31687725-0 2020 Activation of Nrf2 by lead sulfide nanoparticles induces impairment of learning and memory. Sulfides 27-34 NFE2 like bZIP transcription factor 2 Rattus norvegicus 14-18 31530164-8 2020 For metmyoglobin and methemoglobin, the coordination of sulfide leads to noncanonical functions: sulfide storage and its oxidative detoxification have been evidenced under physiological and excess sulfide concentrations, respectively. Sulfides 56-63 hemoglobin subunit gamma 2 Homo sapiens 21-34 31530164-8 2020 For metmyoglobin and methemoglobin, the coordination of sulfide leads to noncanonical functions: sulfide storage and its oxidative detoxification have been evidenced under physiological and excess sulfide concentrations, respectively. Sulfides 97-104 hemoglobin subunit gamma 2 Homo sapiens 21-34 31530164-8 2020 For metmyoglobin and methemoglobin, the coordination of sulfide leads to noncanonical functions: sulfide storage and its oxidative detoxification have been evidenced under physiological and excess sulfide concentrations, respectively. Sulfides 97-104 hemoglobin subunit gamma 2 Homo sapiens 21-34 31530173-5 2020 A relatively stable metHb-sulfide complex forms when H<sub>2</sub>S and purified metHb react <i>in vitro</i>, with an affinity within the <i>in vivo </i>physiological range of sulfide in the blood. Sulfides 26-33 Leucine transport, high Homo sapiens 53-57 31385583-3 2020 Sulfur assimilation in bacteria has been well studied, and sulfide:quinone oxidoreductase, persulfide dioxygenase, rhodanese, and sulfite oxidase were reported as major sulfide-oxidizing enzymes of sulfide assimilation and detoxification pathways. Sulfides 59-66 crystallin zeta Homo sapiens 67-89 31815452-5 2020 It was determined that UGT2B7 converts bromfenac to BI, and that while CYP2C8, CYP2C9 and CYP2C19 catalyze the hydroxylation of bromfenac, only CYP2C9 forms thioether adducts when incubated with NAC or GSH as trapping agents. Sulfides 157-166 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 144-150 31829607-5 2020 Here we report our results on lasing demonstration in MIR (3-4 m) based on a unique combination of high-quality material growth on Silicon substrate and the choice of an intrinsically-strong MIR material in lead sulfide (PbS). Sulfides 213-220 membrane associated ring-CH-type finger 8 Homo sapiens 54-57 31761035-4 2020 With the sulfide concentration increasing, the Ag2S constantly formed, and consequently the SERS signal intensity of Au@4-MBN@Ag gradually decreased owing to the weaker SERS activity of Ag2S. Sulfides 9-16 angiotensin II receptor type 1 Homo sapiens 47-51 31761035-4 2020 With the sulfide concentration increasing, the Ag2S constantly formed, and consequently the SERS signal intensity of Au@4-MBN@Ag gradually decreased owing to the weaker SERS activity of Ag2S. Sulfides 9-16 angiotensin II receptor type 1 Homo sapiens 186-190 31829607-5 2020 Here we report our results on lasing demonstration in MIR (3-4 m) based on a unique combination of high-quality material growth on Silicon substrate and the choice of an intrinsically-strong MIR material in lead sulfide (PbS). Sulfides 213-220 membrane associated ring-CH-type finger 8 Homo sapiens 192-195 31867213-6 2020 For the first time, we further expanded this toolkit to edit three sulfur house-keeping genetic markers (40%-75% for MET2, MET6 and MET25), which confers yeast distinct colony color changes due to the formation of PbS (lead sulfide) precipitates. Sulfides 224-231 homoserine O-acetyltransferase Saccharomyces cerevisiae S288C 117-121 31769766-0 2019 Thioether-based recyclable metal-organic frameworks for selective and efficient removal of Hg2+ from water. Sulfides 0-9 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 91-94 31842297-3 2019 Previously, we reported that SOD is also a sulfide oxidase catalyzing the oxidation of hydrogen sulfide (H2S) to hydrogen persulfide (H2S2) and longer-chain polysulfides (H2Sn, n = 3-7). Sulfides 43-50 superoxide dismutase 1 Homo sapiens 29-32 31539849-7 2019 The results of redundancy analysis revealed that the availability of substrates and sulfides in sediments, rather than the bacteria gene abundance, were the most important factor influencing the NO3- reduction processes. Sulfides 84-92 NBL1, DAN family BMP antagonist Homo sapiens 195-198 31769895-4 2020 Owing to the presence of sulfide interfaces, the PtNiCo/NiCoS IFNWs enable an impressive methanol/ethanol oxidation reaction (MOR/EOR) performance and excellent anti-CO poisoning tolerance. Sulfides 25-32 opioid receptor mu 1 Homo sapiens 126-129 31491633-8 2019 Therefore, in anaerobic ecosystems, the effects of macro metals on APA under conditions of sulfide accumulation may have innovative implications for phosphorus management. Sulfides 91-98 glutamyl aminopeptidase Homo sapiens 67-70 31657521-2 2019 To characterize as-yet-unknown pathophysiologies of schizophrenia, we undertook proteomics analysis of the brain in these strains, and detected elevated levels of Mpst, a hydrogen sulfide (H2 S)/polysulfide-producing enzyme, and greater sulfide deposition in C3H than B6 mice. Sulfides 180-187 mercaptopyruvate sulfurtransferase Mus musculus 163-167 31657521-3 2019 Mpst-deficient mice exhibited improved PPI with reduced storage sulfide levels, while Mpst-transgenic (Tg) mice showed deteriorated PPI, suggesting that "sulfide stress" may be linked to PPI impairment. Sulfides 64-71 mercaptopyruvate sulfurtransferase Mus musculus 0-4 31657521-3 2019 Mpst-deficient mice exhibited improved PPI with reduced storage sulfide levels, while Mpst-transgenic (Tg) mice showed deteriorated PPI, suggesting that "sulfide stress" may be linked to PPI impairment. Sulfides 154-161 mercaptopyruvate sulfurtransferase Mus musculus 0-4 31657521-3 2019 Mpst-deficient mice exhibited improved PPI with reduced storage sulfide levels, while Mpst-transgenic (Tg) mice showed deteriorated PPI, suggesting that "sulfide stress" may be linked to PPI impairment. Sulfides 154-161 mercaptopyruvate sulfurtransferase Mus musculus 86-90 31867213-6 2020 For the first time, we further expanded this toolkit to edit three sulfur house-keeping genetic markers (40%-75% for MET2, MET6 and MET25), which confers yeast distinct colony color changes due to the formation of PbS (lead sulfide) precipitates. Sulfides 224-231 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase Saccharomyces cerevisiae S288C 123-127 31867213-6 2020 For the first time, we further expanded this toolkit to edit three sulfur house-keeping genetic markers (40%-75% for MET2, MET6 and MET25), which confers yeast distinct colony color changes due to the formation of PbS (lead sulfide) precipitates. Sulfides 224-231 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Saccharomyces cerevisiae S288C 132-137 31693344-7 2019 The latter mixture can also react with HS-, giving HNO and HS2- (hydrogen disulfide), a S0(sulfane)-transfer reagent toward {(H)SNO}, leading to SSNO-, a moderately stable species that slowly decomposes in aqueous sulfide-containing solutions in the minute-hour time scale, depending on [O2]. Sulfides 76-83 strawberry notch homolog 1 Homo sapiens 128-131 31603301-3 2019 The optimal Ni-BDC@NiS catalyst acquires a current density of 20 mA cm-2 at a lower overpotential of 330 mV and low Tafel slope of 62 mV dec-1, outperforming previous reported most of Ni-based sulfides catalysts. Sulfides 193-201 deleted in esophageal cancer 1 Homo sapiens 137-142 31620730-3 2019 Moreover, the phase of the ternary sulfide induced by Au single-atom diffusion in Ag2S is determined by the ratio of Au and Ag, thus exhibiting a significant difference in the photocatalytic activity performance. Sulfides 35-42 angiotensin II receptor type 1 Homo sapiens 82-86 31531948-4 2019 On account of the electrophilic addition of Cl+ to the sulfide of thiocarbamate moiety, probe RF1 was converted to resorufin and triggered emitting bright. Sulfides 55-62 mitochondrial translation release factor 1 Homo sapiens 94-97 31465952-1 2019 The micro-aerobic condition has proven to effectively enhance the COD removal and elemental sulfur (S0) transformation rate in the sulfate reduction-denitrifying sulfide removal (SR-DSR) process. Sulfides 162-169 macrophage scavenger receptor 1 Mus musculus 179-181 31465952-7 2019 The mechanism explorations revealed that micro-aerobic condition not only particularly enriched the sulfide-oxidizing, nitrate-reducing bacteria (soNRB) but also promoted the microbial zonation of sulfate-reducing bacteria (SRB) and soNRB, thereby achieving more S0 transformation in the effluent. Sulfides 100-107 chaperonin containing TCP1 subunit 4 Homo sapiens 197-238 31119834-0 2019 TLR2 and TLR4 interact with sulfide system in the modulation of mouse colonic motility. Sulfides 28-35 toll-like receptor 2 Mus musculus 0-4 31427145-0 2019 Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold. Sulfides 93-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 75-80 30912813-5 2019 In this essay, I argue that because of its resistance to sulfide, AOX respiration was critical to the evolution of animals by enabling oxidative metabolism under otherwise inhibitory conditions. Sulfides 57-64 acyl-CoA oxidase 1 Homo sapiens 66-69 31100687-2 2019 On this basis, the hydrogen production performance of the bimetallic sulfide CuCo2S4 (CCS-3) was compared with that of the single metal sulfides Cu31S16 and CoS2. Sulfides 69-76 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 86-91 31100687-3 2019 The results showed that the bimetallic sulfide CCS-3 significantly improved the photocatalytic hydrogen production performance. Sulfides 39-46 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 47-52 31100687-4 2019 The unique structure of the bimetallic sulfide CCS-3 made the photocatalytic activity of H2 2.47 times and 178.08 times higher than that of Cu31S16 and CoS2, respectively. Sulfides 39-46 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 47-52 31484985-1 2019 T-DM1 is an antibody drug conjugate that combines trastuzumab with emtansine via a stable thioether linker. Sulfides 90-99 immunoglobulin heavy diversity 1-7 Homo sapiens 2-5 31119834-11 2019 The in vivo activation of TLR4 with lipopolysaccharide increased the contractile response to PAG, mRNA levels of CSE, and the free sulfide levels of H2 S in colon. Sulfides 131-138 toll-like receptor 4 Mus musculus 26-30 31119834-13 2019 Deficiency of TLR2 or TLR4 provokes alterations in free sulfide levels and SRB of colon. Sulfides 56-63 toll-like receptor 4 Mus musculus 22-26 31568617-2 2019 In a recent study, Domen and co-workers developed an innovative strategy to stabilize sulfide-based photocatalysts by hybridizing S 3p with O 2p orbitals to produce oxysulfides in which S2- is stable. Sulfides 86-93 immunoglobulin kappa variable 1D-39 Homo sapiens 140-144 31551776-1 2019 Modulation of nociception and inflammation by sulfide in rheumatoid arthritis and activation of transient receptor potential ankyrin 1 (TRPA1) ion channels by sulfide compounds are well documented. Sulfides 159-166 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 96-134 31551776-1 2019 Modulation of nociception and inflammation by sulfide in rheumatoid arthritis and activation of transient receptor potential ankyrin 1 (TRPA1) ion channels by sulfide compounds are well documented. Sulfides 159-166 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 136-141 31551776-2 2019 The present study aims to investigate TRPA1-mediated effects of sulfide donor GYY4137 in K/BxN serum-transfer arthritis, a rodent model of rheumatoid arthritis. Sulfides 64-71 transient receptor potential cation channel subfamily A member 1 Homo sapiens 38-43 31119834-0 2019 TLR2 and TLR4 interact with sulfide system in the modulation of mouse colonic motility. Sulfides 28-35 toll-like receptor 4 Mus musculus 9-13 31213529-6 2019 We found that sulfide quinone oxidoreductase (SQR), which catalyzes the committing step in the mitochondrial sulfide oxidation pathway and couples to complex III, is a critical respiratory shield against H2S poisoning. Sulfides 14-21 crystallin zeta Homo sapiens 22-44 31468185-7 2019 ALP hydrolyzes the substrate p-nitrophenyl phosphate (pNPP) under formation of phosphate ions which stabilize CdS QDs that are grown in-situ from cadmium(II) and sulfide. Sulfides 162-169 alkaline phosphatase, placental Homo sapiens 0-3 31313776-4 2019 CP2 is the only 2nd example of emissive thioether/CuCl-containing material and combined DFT/TDDFT computations suggest the presence of lowest energy M/XLCT excited states. Sulfides 40-49 ceruloplasmin Homo sapiens 0-3 31395877-4 2019 By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters. Sulfides 42-49 iron-sulfur cluster assembly enzyme Homo sapiens 21-25 31398901-5 2019 Both the glycone moiety and the aglycone tail can be modified by using sp2-iminosugar precursors with different configurational profiles (d-gluco or d-galacto in this work) and varied thiols, as well as by oxidation of the sulfide adducts (to the corresponding sulfones in this work). Sulfides 223-230 Sp2 transcription factor Homo sapiens 71-74 31395877-3 2019 Here, we report the breakdown of this process, made possible by removing a zinc ion in ISCU that hinders iron insertion and promotes non-physiological Fe-S cluster synthesis from free sulfide in vitro. Sulfides 184-191 iron-sulfur cluster assembly enzyme Homo sapiens 87-91 31395877-4 2019 By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters. Sulfides 42-49 NFS1 cysteine desulfurase Homo sapiens 62-66 31395877-4 2019 By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters. Sulfides 42-49 ferredoxin 2 Homo sapiens 115-119 31395877-4 2019 By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters. Sulfides 81-88 iron-sulfur cluster assembly enzyme Homo sapiens 21-25 31395877-4 2019 By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters. Sulfides 81-88 ferredoxin 2 Homo sapiens 115-119 31382676-2 2019 The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides being respectively involved in the synthesis and catabolism of H2S, generate sulfane sulfur species such as persulfides and polysulfides, currently recognized as mediating some of the H2S biological effects. Sulfides 138-145 crystallin zeta Homo sapiens 146-168 31367318-6 2019 The ether/thioether-functionalized network polymer, PAF-1-ET, exhibits high selectivity for the uptake of iron(ii) and iron(iii) over other physiologically and environmentally relevant metal ions. Sulfides 10-19 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 52-57 31300717-4 2019 Ag2S employed as working electrode demonstrates notable faradaic behaviour including high reversible specific capacitance value of 179 C/g at a constant charge/discharge current density of 1 A/g with high cyclic stability which is relatively good as compared with other sulphide based materials. Sulfides 270-278 angiotensin II receptor type 1 Homo sapiens 0-4 31333616-0 2019 Feasability of Introducing a Thioether Ring in Vasopressin by nisBTC Co-expression in Lactococcus lactis. Sulfides 29-38 arginine vasopressin Homo sapiens 47-58 31333616-7 2019 Here, we show it is possible to direct the biosynthesis of vasopressin variants in such a way that the disulfide bridge is replaced by a thioether bridge using the nisin modification machinery NisBTC, albeit at low efficiency. Sulfides 137-146 arginine vasopressin Homo sapiens 59-70 31333616-10 2019 LC-MS/MS data verified the formation of a thioether bridge, which provides proof of principle for this modification in vasopressin. Sulfides 42-51 arginine vasopressin Homo sapiens 119-130 31145582-9 2019 Such a large improvement can be attributed to the synergistic effect resulting from the enhanced active site density of both sulfides and to the improved electrical conductivity at the interfaces between MoS2 and Ag2S. Sulfides 125-133 angiotensin II receptor type 1 Homo sapiens 213-217 30918001-6 2019 We conjugated HL-2 with an antibody that targeted CD24 through a thioether bond to generate an ADC-like immunoconjugate, antibody-nitric oxide conjugate (ANC), which we named HN-01. Sulfides 65-74 CD24 molecule Homo sapiens 50-54 30399433-1 2019 We report here the effects of hydrogen sulfide (sulfide), that accumulates in ETHE1 deficiency, in rat cerebellum. Sulfides 39-46 ETHE1, persulfide dioxygenase Rattus norvegicus 78-83 31261676-4 2019 Moreover, with the further increase in the aging temperature to 850 C, oxides containing Mn and Cr (CrMn1.5O4) and sulfides (MnS) precipitated from the samples, further decreasing their pitting corrosion resistance and tensile strength. Sulfides 116-124 glycophorin E (MNS blood group) Homo sapiens 126-129 30776218-2 2019 The spin label links to cysteines via a short thioether tether and has a narrow central transition indicative of small zero-field splitting (ZFS). Sulfides 46-55 spindlin 1 Homo sapiens 4-8 30870594-9 2019 Interestingly, for the ferrihydrite colloids with higher hydrodynamic diameter, aggregation rates linearly decreases with increasing sulfide concentration from 156.3 to 312.5 muM, which is likely due to the formation of substantial amounts of negatively charged S(0) and FeS. Sulfides 133-140 latexin Homo sapiens 175-178 30861620-7 2019 Sulfide analogues were identified that are devoid of the risk of quinone formation, but possess potent KV 7.2/3 opening activity. Sulfides 0-7 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 103-111 30933504-0 2019 Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic beta-(1 3)-Glucan Mimetics. Sulfides 39-48 immunoglobulin kappa variable 2D-18 (pseudogene) Homo sapiens 68-77 30933504-1 2019 Extrapolating from lessons learnt with previous low-molecular-weight beta-(1 3)-glucan mimetics, we designed a series of minimal 2,4-dideoxy-thioether-linked carbacyclic beta-(1 3)-glucan mimetics and synthesized di-, tri-, and tetramers in an enantiomerically pure form by an iterative sequence based on a simple building block readily available from commercial ( S)-(-)-3-cyclohexenecarboxylic acid. Sulfides 140-150 immunoglobulin kappa variable 2D-18 (pseudogene) Homo sapiens 69-78 30933504-1 2019 Extrapolating from lessons learnt with previous low-molecular-weight beta-(1 3)-glucan mimetics, we designed a series of minimal 2,4-dideoxy-thioether-linked carbacyclic beta-(1 3)-glucan mimetics and synthesized di-, tri-, and tetramers in an enantiomerically pure form by an iterative sequence based on a simple building block readily available from commercial ( S)-(-)-3-cyclohexenecarboxylic acid. Sulfides 140-150 immunoglobulin kappa variable 2D-18 (pseudogene) Homo sapiens 170-179 30716544-5 2019 The adsorption isotherms show that the adsorption of As on alpha-Fe2O3 is largely inhibited by the presence of aqueous sulfide at pH 7 with low As equilibrium concentration (<40 mg L-1). Sulfides 119-126 L1 cell adhesion molecule Homo sapiens 184-187 30871199-6 2019 Moreover, Cbl markedly inhibited the catecholamine release and [Ca2+]i rise caused by hypoxia in isolated CBs and dispersed glomus cells, respectively, whereas it did not alter these responses when they were evoked by high [K+]e. The L-type Ca2+ channel blocker nifedipine slightly inhibited the rise in CB chemoreceptor cells [Ca2+]i elicited by sulfide, whilst causing a somewhat larger attenuation of the hypoxia-induced Ca2+ signal. Sulfides 347-354 Cbl proto-oncogene Rattus norvegicus 10-13 30577117-2 2019 Firstly, sulphides (0.5 g L-1) and sulphites (2.5 g L-1) were catalytic oxidised at natural pH (8.7). Sulfides 9-18 L1 cell adhesion molecule Homo sapiens 26-29 30577117-2 2019 Firstly, sulphides (0.5 g L-1) and sulphites (2.5 g L-1) were catalytic oxidised at natural pH (8.7). Sulfides 9-18 L1 cell adhesion molecule Homo sapiens 52-55 30577117-5 2019 Concentrations of sulphide and sulphite lower than 1.0 mg L-1 (emission limit value - ELV) were obtained after 5-h oxygenation or 1-min peroxidation under the best conditions, i.e. air flow rate of 1 Lair Lleachate-1 min-1 and H2O2:sulphur stoichiometric ratio. Sulfides 18-26 L1 cell adhesion molecule Homo sapiens 58-61 30529602-7 2019 S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. Sulfides 131-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 30292176-0 2019 Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 channels. Sulfides 11-18 transient receptor potential cation channel subfamily A member 1 Homo sapiens 104-109 30292176-6 2019 Although sulfide and polysulfide effects in different pathological circumstances and TRPA1-mediated processes have been investigated intensively, our review attempts to present the first comprehensive overview of the potential crosstalk between TRPA1 channels and sulfide-activated signalling pathways. Sulfides 9-16 transient receptor potential cation channel subfamily A member 1 Homo sapiens 245-250 30292176-6 2019 Although sulfide and polysulfide effects in different pathological circumstances and TRPA1-mediated processes have been investigated intensively, our review attempts to present the first comprehensive overview of the potential crosstalk between TRPA1 channels and sulfide-activated signalling pathways. Sulfides 25-32 transient receptor potential cation channel subfamily A member 1 Homo sapiens 245-250 30735362-4 2019 In contrast, coordinating counterions, such as Cl-, favor neutral Rh complexes in which the diene binds eta2 to afford homoallylic sulfides. Sulfides 131-139 DNA polymerase iota Homo sapiens 104-108 30529602-7 2019 S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. Sulfides 131-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-168 30428991-5 2018 By the acidification process, a limit of detection of 7.7 muM by the proposed method was obtained for both sulfide and sulfite in aqueous medium, and this method was successfully utilized to analysis of real samples. Sulfides 107-114 latexin Homo sapiens 58-61 30838088-2 2019 H2S is synthesized endogenously and mainly metabolized by a mitochondrial sulfide-oxidizing pathway including sulfide:quinone oxidoreductase (SQR), whereby H2S-derived electrons are injected into the respiratory chain stimulating O2 consumption and ATP synthesis. Sulfides 74-81 crystallin zeta Homo sapiens 118-140 30838088-2 2019 H2S is synthesized endogenously and mainly metabolized by a mitochondrial sulfide-oxidizing pathway including sulfide:quinone oxidoreductase (SQR), whereby H2S-derived electrons are injected into the respiratory chain stimulating O2 consumption and ATP synthesis. Sulfides 110-117 crystallin zeta Homo sapiens 118-140 30138885-2 2019 We studied chemical transformations that Ag NPs may undergo as they pass through sulfide-rich conditions common in waste water treatment plants (WWTPs), which may limit the release of Ag+ from Ag NPs due to the formation of low-solubility silver sulfide (Ag2S). Sulfides 81-88 angiotensin II receptor type 1 Homo sapiens 255-259 30391543-0 2019 Deficiency of the mitochondrial sulfide regulator ETHE1 disturbs cell growth, glutathione level and causes proteome alterations outside mitochondria. Sulfides 32-39 ETHE1 persulfide dioxygenase Homo sapiens 50-55 30391543-1 2019 The mitochondrial enzyme ETHE1 is a persulfide dioxygenase essential for cellular sulfide detoxification, and its deficiency causes the severe and complex inherited metabolic disorder ethylmalonic encephalopathy (EE). Sulfides 39-46 ETHE1 persulfide dioxygenase Homo sapiens 25-30 31148115-0 2019 Measurements for Sulfide-Mediated Inhibition of Myeloperoxidase Activity. Sulfides 17-24 myeloperoxidase Homo sapiens 48-63 31148115-3 2019 In conditions where sulfide was proposed to be protective against oxidative stress- or inflammation-induced tissue damage (e.g., reperfusion injury, atherosclerosis, vascular inflammation), the reactive oxidant-producing function of a key neutrophil enzyme, myeloperoxidase, was reported to be a protagonist on the detrimental side. Sulfides 20-27 myeloperoxidase Homo sapiens 258-273 31148115-4 2019 We recently described favorable interactions between sulfide and myeloperoxidase and proposed that the potent inhibition of myeloperoxidase activities could contribute to sulfide"s beneficial functions in a number of cardiovascular pathologies. Sulfides 171-178 myeloperoxidase Homo sapiens 65-80 31148115-4 2019 We recently described favorable interactions between sulfide and myeloperoxidase and proposed that the potent inhibition of myeloperoxidase activities could contribute to sulfide"s beneficial functions in a number of cardiovascular pathologies. Sulfides 171-178 myeloperoxidase Homo sapiens 124-139 31148115-5 2019 Our chapter is dedicated to aid future studies and drug development endeavors in this area by providing methodological guidance on how to assess the inhibitory potential of sulfide on myeloperoxidase enzymatic activities in isolated protein systems, in neutrophil homogenates, and in live neutrophil preparations. Sulfides 173-180 myeloperoxidase Homo sapiens 184-199 30542774-4 2018 Sulfide can be detected in concentrations up to 2.0 muM, and the detection limit is 15 nM. Sulfides 0-7 latexin Homo sapiens 52-55 30525539-0 2018 Correction to "Sulfide Protects [FeFe] Hydrogenases From O2". Sulfides 15-22 immunoglobulin kappa variable 1D-39 Homo sapiens 57-60 30563894-2 2018 Cytochrome c biogenesis in prokaryotes requires the transport of heme from inside to outside for stereospecific attachment to cytochrome c via two thioether bonds (at CXXCH). Sulfides 147-156 cytochrome c, somatic Homo sapiens 0-12 30563894-2 2018 Cytochrome c biogenesis in prokaryotes requires the transport of heme from inside to outside for stereospecific attachment to cytochrome c via two thioether bonds (at CXXCH). Sulfides 147-156 cytochrome c, somatic Homo sapiens 126-138 30613322-5 2018 Thioether 36 showed significant inhibition of MPO activity in an acute mouse inflammation model after oral dosing. Sulfides 0-9 myeloperoxidase Mus musculus 46-49 30141069-3 2018 Recently, we have reported that many heterotrophic bacteria can use sulfide:quinone oxidoreductase and persulfide dioxygenase to oxidize H2S to thiosulfate and sulfite. Sulfides 68-75 crystallin zeta Homo sapiens 76-98 29864659-3 2018 When sulfide was present at measurable concentrations (>0.02 mg/L), Hg-S complexes dominated iHg species, occurring in the forms of HgS22-, HgHS2-, and Hg(HS)2 that were affected by a variety of environmental factors. Sulfides 5-12 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 71-75 30391046-6 2018 Atmospheric N and S deposition, nitrification of soil N, and sulfide oxidation control the background levels of groundwater NO3- and SO42-. Sulfides 61-68 NBL1, DAN family BMP antagonist Homo sapiens 124-127 29864668-9 2018 The co-occurrence of iron and sulfide in filtered soil porewaters, sometimes both above 100 muM, suggests the presence of nanoparticulate and/or colloidal metal sulfides. Sulfides 30-37 latexin Homo sapiens 92-95 30255178-4 2018 Herein, we report the design and synthesis of a ROS-triggered prodrug nanoplatform fabricated with oxidation-responsive cabazitaxel (CTX) prodrugs for synergistic chemo-photodynamic therapy, thioether-/selenoether-linked conjugates of CTX and oleic acid (OA). Sulfides 191-200 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 133-136 30255178-4 2018 Herein, we report the design and synthesis of a ROS-triggered prodrug nanoplatform fabricated with oxidation-responsive cabazitaxel (CTX) prodrugs for synergistic chemo-photodynamic therapy, thioether-/selenoether-linked conjugates of CTX and oleic acid (OA). Sulfides 191-200 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 235-238 29864659-5 2018 However, when sulfide was presumably present at a very low, environmentally relevant concentration (3.2 x 10-7 mg/L), both Hg-DOM and Hg-S complexes were present as the major iHg species. Sulfides 14-21 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 134-138 29864659-6 2018 These Hg-S species and Hg-DOM complex could be related to methylmercury (MeHg) in environmental matrices such floc, periphyton, and soil, and the correlations are dependent upon different circumstances (e.g., sulfide concentrations). Sulfides 209-216 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 6-10 28477161-2 2018 In the preliminary period, the DGT with zirconium hydroxide-silver iodide as the binding phase (ZrO-AgI DGT) has been developed for the determination of sulfide (S(II)). Sulfides 153-160 transcription elongation factor A1 Homo sapiens 162-167 30299927-4 2018 All the five metallic LiMS2 (M = Cr, Mn, Fe, Co, and Ni) materials are superionic conductors with extremely small lithium ion migration barriers in the range from 43 to 99 meV, much lower than most oxide- and even sulfide-type cathodes. Sulfides 214-221 LIM zinc finger domain containing 2 Homo sapiens 22-27 30221506-5 2018 Upon addition of sulfide, the chelated Ag+ ions in the long-nicked DNA poly strands by hybridization chain reaction reacted with sulfide to generate Ag2S nanoparticles. Sulfides 17-24 angiotensin II receptor type 1 Homo sapiens 149-153 30221506-5 2018 Upon addition of sulfide, the chelated Ag+ ions in the long-nicked DNA poly strands by hybridization chain reaction reacted with sulfide to generate Ag2S nanoparticles. Sulfides 129-136 angiotensin II receptor type 1 Homo sapiens 149-153 30247895-5 2018 The crystal structure of the purple [RhII2(AcO)2(d-Met)(l-Met)] 6H2O compound obtained from the solution revealed tridentate coordination of the methionine ligands to the Rh(II) ions, with the thioether S atoms in equatorial positions. Sulfides 193-202 aconitase 2 Homo sapiens 37-48 30323799-7 2018 The generated sulfide was metabolized via sulfite and ultimately to sulfate mediated by reverse dissimilatory sulfite reductase, APS reductase, and sulfate adenylyltransferase and the released electrons were potentially transferred to the anode via soluble electron shuttles. Sulfides 14-21 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Homo sapiens 148-175 30129561-1 2018 We previously showed that thioether levels in the exhaled breath volatiles of volunteers undergoing controlled human malaria infection (CHMI) with P. falciparum increase as infection progresses. Sulfides 26-35 chondromodulin Homo sapiens 136-140 29684324-4 2018 Two different enzymes with sulfide oxidation activity (sulfide dehydrogenases) are known: flavocytochrome c sulfide dehydrogenase (FCSD), a sulfide:cytochrome c oxidoreductase; and sulfide:quinone oxidoreductase (SQR). Sulfides 27-34 crystallin zeta Homo sapiens 189-211 30133269-1 2018 The removal of arsenic and metals by sulfide (S(-II)) from acidic wastewater is an efficient method. Sulfides 37-44 transcription elongation factor A1 Homo sapiens 46-51 29966080-0 2018 Cytochrome c Reduction by H2S Potentiates Sulfide Signaling. Sulfides 42-49 cytochrome c, somatic Homo sapiens 0-12 29966080-8 2018 These results reveal a potential role for the electron transfer chain in general, and Cyt C in particular, for potentiating sulfide-based signaling. Sulfides 124-131 cytochrome c, somatic Homo sapiens 86-91 29980601-3 2018 Persulfide dioxygenase (PDO or ETHE1) is a mononuclear non-heme iron-containing protein in the sulfide oxidation pathway catalyzing the conversion of GSH persulfide (GSSH) to sulfite and GSH. Sulfides 3-10 ETHE1 persulfide dioxygenase Homo sapiens 31-36 30014689-0 2018 Energy Level Alignment of Molybdenum Oxide on Colloidal Lead Sulfide (PbS) Thin Films for Optoelectronic Devices. Sulfides 61-68 cholinergic receptor muscarinic 3 Homo sapiens 70-73 29868651-4 2018 At lower concentrations of CS2, less dinitrogen functionalization is observed; instead, N2 is displaced and the CS2 molecule is completely disassembled to generate a ditantalum derivative with bridging methylene and two sulfide moieties. Sulfides 220-227 chorionic somatomammotropin hormone 2 Homo sapiens 27-30 29868662-3 2018 Abnormalities in blood serum sulfide can be an indication of several diseases, including diabetes, wherein there is a significant reduction in the sulfide ion concentration (<10 muM). Sulfides 29-36 latexin Homo sapiens 181-184 29868662-3 2018 Abnormalities in blood serum sulfide can be an indication of several diseases, including diabetes, wherein there is a significant reduction in the sulfide ion concentration (<10 muM). Sulfides 147-154 latexin Homo sapiens 181-184 29868662-5 2018 The electrode exhibits a detection range of 1-100 muM, and is suitable for the common biochemical interference-free detection of blood serum sulfide in pH 7 phosphate buffer solution. Sulfides 141-148 latexin Homo sapiens 50-53 29868662-8 2018 A constructed FIA calibration plot (applied potential, Eapp = 0.15 V vs. Ag/AgCl) was linear in the sulfide concentration ranges of 1-100 muM (1st region) and 300 muM-5 mM (2nd region) with a detection limit value of 700 nM. Sulfides 100-107 E2F associated phosphoprotein Homo sapiens 55-59 29868662-8 2018 A constructed FIA calibration plot (applied potential, Eapp = 0.15 V vs. Ag/AgCl) was linear in the sulfide concentration ranges of 1-100 muM (1st region) and 300 muM-5 mM (2nd region) with a detection limit value of 700 nM. Sulfides 100-107 latexin Homo sapiens 138-141 29868662-8 2018 A constructed FIA calibration plot (applied potential, Eapp = 0.15 V vs. Ag/AgCl) was linear in the sulfide concentration ranges of 1-100 muM (1st region) and 300 muM-5 mM (2nd region) with a detection limit value of 700 nM. Sulfides 100-107 latexin Homo sapiens 163-166 29978443-6 2018 The method shows excellent selectivity over many potentially interfering ions and has been successfully applied to the determination of sulfide ions in spiked tap water, lake water and the synthetic wastewater samples. Sulfides 136-143 nuclear RNA export factor 1 Homo sapiens 159-162 31950636-1 2018 Heterobimetallic Group 11/13 sulfide nanoparticles (AgInS2 , CuInS2 , Ag9 GaS6 , and CuGaS2 ) are formed by treatment of [M(S2 CAr)3 ] (M=Ga or In) with either AgNO3 or CuCl under mild conditions. Sulfides 29-36 growth arrest specific 6 Homo sapiens 74-78 29689452-3 2018 In eukaryotes a [2Fe-2S] cluster is first assembled in the mitochondria on the iron-sulfur cluster scaffold protein ISCU in tandem with iron, sulfide, and electron donors. Sulfides 142-149 iron-sulfur cluster assembly enzyme Homo sapiens 116-120 29868651-4 2018 At lower concentrations of CS2, less dinitrogen functionalization is observed; instead, N2 is displaced and the CS2 molecule is completely disassembled to generate a ditantalum derivative with bridging methylene and two sulfide moieties. Sulfides 220-227 chorionic somatomammotropin hormone 2 Homo sapiens 112-115 29884814-4 2018 Our data indicate that, from ~2.45 Gyr to beyond 2.31 Gyr, MIF-S was preserved in sulphides punctuated by several episodes of MIF-S disappearance. Sulfides 82-91 macrophage migration inhibitory factor Homo sapiens 59-62 29631788-0 2018 Design and discovery of thioether and nicotinamide containing sorafenib analogues as multikinase inhibitors targeting B-Raf, B-RafV600E and VEGFR-2. Sulfides 24-33 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 118-123 29984921-3 2018 SDF-1 was covalently conjugated to the surface of the nanoparticles through thioether bonding. Sulfides 76-85 C-X-C motif chemokine ligand 12 Homo sapiens 0-5 29727184-4 2018 Biological assays carried out in vitro on human MMPs with the resulting compounds led to identification of a sulfide, 4a, bearing an N-1-hydroxypiperidine-2,6-dione (HPD) group as new ZBG. Sulfides 109-116 matrix metallopeptidase 1 Homo sapiens 48-52 29631788-0 2018 Design and discovery of thioether and nicotinamide containing sorafenib analogues as multikinase inhibitors targeting B-Raf, B-RafV600E and VEGFR-2. Sulfides 24-33 kinase insert domain receptor Homo sapiens 140-147 28951093-0 2018 Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Sulfides 0-9 EH domain containing 1 Homo sapiens 61-65 29665240-3 2018 TET1 inhibitors based on a scaffold of thioether macrocyclic peptides, which have been discovered by the random nonstandard peptide integrated discovery (RaPID) system, are reported. Sulfides 39-48 tet methylcytosine dioxygenase 1 Homo sapiens 0-4 29665240-4 2018 The affinity-based selection was performed against the TET1 compact catalytic domain (TET1CCD) to yield thioether macrocyclic peptides. Sulfides 104-113 tet methylcytosine dioxygenase 1 Homo sapiens 55-59 29220697-12 2018 It is also possible that H2S (or polysulfides) interact/react with SOD cysteines to affect catalytic activity or to directly contribute to sulfide metabolism. Sulfides 37-44 superoxide dismutase 1 Homo sapiens 67-70 29220697-13 2018 Our studies suggest that H2S metabolism by SOD may have been an ancient mechanism to detoxify sulfide or to regulate RSS and along with catalase may continue to do so in contemporary organisms. Sulfides 94-101 superoxide dismutase 1 Homo sapiens 43-46 29611421-4 2018 Upon exposure to sulfide ions, the photocurrent of the functionalized photoanode proportionately decreases in response to the formation of CdS nanoparticles. Sulfides 17-24 CDP-diacylglycerol synthase 1 Homo sapiens 139-142 29173629-8 2018 MET1 may be a key gene in sulfide biosynthesis owing to its involvement in almost all strains. Sulfides 26-33 uroporphyrinogen-III C-methyltransferase Saccharomyces cerevisiae S288C 0-4 29316471-4 2018 Results showed a sulfide build-up rate of 3.24 g S-2 m-2 d-1 in the summer and of 2.30 g S-2 m-2 d-1 during the winter. Sulfides 17-24 ribosomal protein S2 Homo sapiens 49-52 29409925-6 2018 However, sulfide reacts with methemoglobin (metHb), forming a methemoglobin-sulfide (metHb-SH) complex. Sulfides 9-16 hemoglobin subunit gamma 2 Homo sapiens 29-42 29409925-6 2018 However, sulfide reacts with methemoglobin (metHb), forming a methemoglobin-sulfide (metHb-SH) complex. Sulfides 9-16 hemoglobin subunit gamma 2 Homo sapiens 62-75 29316471-5 2018 The ratio of sulfate reduction to sulfide production (SO4-2/S-2) was of roughly 3 to 1, as expected. Sulfides 34-41 ribosomal protein S2 Homo sapiens 60-63 29103647-5 2018 The accumulation of Fe(II) and sulfide in microcosms amended with LNP indicates that schwertmannite/jarosite transformation is mediated by microbial reduction. Sulfides 31-38 lunapark, ER junction formation factor Homo sapiens 66-69 29495639-6 2018 It has been proven that the system herein proposed is able to measure sulfide concentration in a linear range from 0-10 mg L-1 with a sensitivity value of about 6.7 microA mg-1 L and a detection limit of 0.5 mg L-1. Sulfides 70-77 immunoglobulin kappa variable 1-16 Homo sapiens 123-126 29495639-6 2018 It has been proven that the system herein proposed is able to measure sulfide concentration in a linear range from 0-10 mg L-1 with a sensitivity value of about 6.7 microA mg-1 L and a detection limit of 0.5 mg L-1. Sulfides 70-77 immunoglobulin kappa variable 1-16 Homo sapiens 211-214 29278485-1 2018 Photochemical reduction of H2O and CO2 has been investigated with a new family of catalysts of the formula Cd4P2X3 (X= Cl, Br, I), obtained by the complete aliovalent substitution of the sulfide ions in CdS by P and X (Cl, Br, I). Sulfides 187-194 complement C2 Homo sapiens 27-38 29381151-1 2018 An efficient route to deoxygenation of sulphoxides to sulphides with PCl3 under mild reaction condition was developed. Sulfides 54-63 PHD finger protein 19 Homo sapiens 69-73 29381151-2 2018 PCl3 was used as a reducing agent for the first time to convert sulphoxides to sulphides. Sulfides 79-88 PHD finger protein 19 Homo sapiens 0-4 29450120-5 2018 The maximum concentration of sulphide formation was 784 mg/L at COD/sulphate ratio of 0.62 in anaerobic digestion process and the process was inhibited at this sulphide concentration. Sulfides 29-37 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 64-67 28874062-0 2018 Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase. Sulfides 35-45 cystathionine beta-synthase Homo sapiens 49-76 29348167-5 2018 The relatively unstudied human thiosulfate sulfurtransferase-like domain-containing 1 (TSTD1) protein, a single-domain cytoplasmic sulfurtransferase, was also postulated to play a role in the sulfide oxidation pathway using thiosulfate to form glutathione persulfide, for subsequent processing in the mitochondrial matrix. Sulfides 192-199 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 31-85 29348167-5 2018 The relatively unstudied human thiosulfate sulfurtransferase-like domain-containing 1 (TSTD1) protein, a single-domain cytoplasmic sulfurtransferase, was also postulated to play a role in the sulfide oxidation pathway using thiosulfate to form glutathione persulfide, for subsequent processing in the mitochondrial matrix. Sulfides 192-199 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 87-92 29348167-9 2018 The active site exposure and its interaction with thioredoxin suggest that TSTD1 might play a role in sulfide-based signaling. Sulfides 102-109 thioredoxin Homo sapiens 50-61 29348167-9 2018 The active site exposure and its interaction with thioredoxin suggest that TSTD1 might play a role in sulfide-based signaling. Sulfides 102-109 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 75-80 29348167-10 2018 The apical localization of TSTD1 in human colonic crypts, which interfaces with sulfide-releasing microbes, and the overexpression of TSTD1 in colon cancer provide potentially intriguing clues as to its role in sulfide metabolism. Sulfides 80-87 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 27-32 29348167-10 2018 The apical localization of TSTD1 in human colonic crypts, which interfaces with sulfide-releasing microbes, and the overexpression of TSTD1 in colon cancer provide potentially intriguing clues as to its role in sulfide metabolism. Sulfides 211-218 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 27-32 29348167-10 2018 The apical localization of TSTD1 in human colonic crypts, which interfaces with sulfide-releasing microbes, and the overexpression of TSTD1 in colon cancer provide potentially intriguing clues as to its role in sulfide metabolism. Sulfides 211-218 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 134-139 29322773-4 2018 When excited at 785 nm, plasmonic hotspots of the densely arranged 3D gold-nanoparticle pillars as well as strong interaction between sulfide linkages of the insulin molecules and the gold nanoparticles produced highly sensitive and reliable insulin measurements down to 100 pM. Sulfides 134-141 insulin Homo sapiens 158-165 29322773-4 2018 When excited at 785 nm, plasmonic hotspots of the densely arranged 3D gold-nanoparticle pillars as well as strong interaction between sulfide linkages of the insulin molecules and the gold nanoparticles produced highly sensitive and reliable insulin measurements down to 100 pM. Sulfides 134-141 insulin Homo sapiens 242-249 28774789-7 2018 Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain. Sulfides 155-162 cystathionine beta-synthase Homo sapiens 9-12 29261198-0 2018 Hot excitons are responsible for increasing photoluminescence blinking activity in single lead sulfide/cadmium sulfide nanocrystals. Sulfides 95-102 alcohol dehydrogenase iron containing 1 Homo sapiens 0-3 28988048-3 2018 Long HRT (4day) favored the relative abundance of SRB, causing the increase of residual sulfides and short HRT (1day) affected the anaerobic conditions of the bioreactors and favored the presence the acidophilic chemolithotrophic microorganisms. Sulfides 88-96 chaperonin containing TCP1 subunit 4 Homo sapiens 50-53 28774789-7 2018 Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain. Sulfides 155-162 cystathionine beta-synthase Homo sapiens 67-70 28774789-7 2018 Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain. Sulfides 155-162 cystathionine beta-synthase Homo sapiens 123-126 28774789-11 2018 The in vitro study demonstrated that lentivirus-mediated CBS overexpression elevated the sulfide generation in glial cells. Sulfides 89-96 cystathionine beta-synthase Mus musculus 57-60 29088535-5 2017 This is consistent with the widely held view that cytochrome c oxidase (complex IV of the mitochondrial electron-transport system) is the principal molecular target involved in the acute toxicity of "sulfide" (H2S/HS-). Sulfides 199-207 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 50-70 28930587-2 2018 This systematic review summarizes current understanding of this enzyme, now known as prenylcysteine oxidase 1 (PCYOX1), which hydrolyzes the thioether bond of prenylcysteines in the final step in the degradation of prenylated proteins, releasing hydrogen peroxide, cysteine and the isoprenoid aldehyde. Sulfides 141-150 prenylcysteine oxidase 1 Homo sapiens 85-109 28930587-2 2018 This systematic review summarizes current understanding of this enzyme, now known as prenylcysteine oxidase 1 (PCYOX1), which hydrolyzes the thioether bond of prenylcysteines in the final step in the degradation of prenylated proteins, releasing hydrogen peroxide, cysteine and the isoprenoid aldehyde. Sulfides 141-150 prenylcysteine oxidase 1 Homo sapiens 111-117 29088535-7 2017 Respirometric measurements showed the BPAEC to possess a robust sulfide oxidizing system, which was able to out-compete cytochrome c oxidase for available H2S/HS- at micromolar concentrations. Sulfides 64-71 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 120-140 29044748-0 2017 Assembly of Coordination Polymers Using Thioether-Functionalized Octasilsesquioxanes: Occurrence of (CuX)n Clusters (X=Br and I) within 3D-POSS Networks. Sulfides 40-49 cut like homeobox 1 Homo sapiens 101-104 28777380-1 2017 Sulfide (H2S, HS- and S2-) oxidation to sulfite and thiosulfate by heterotrophic bacteria, using sulfide:quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO), has recently been reported as a possible detoxification mechanism for sulfide at high levels. Sulfides 0-7 quinone oxidoreductase Pseudomonas aeruginosa PAO1 105-127 28777380-1 2017 Sulfide (H2S, HS- and S2-) oxidation to sulfite and thiosulfate by heterotrophic bacteria, using sulfide:quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO), has recently been reported as a possible detoxification mechanism for sulfide at high levels. Sulfides 97-104 quinone oxidoreductase Pseudomonas aeruginosa PAO1 105-127 28578235-3 2017 Although a widely used method, SRB activity is often not completely inhibited, and as such sulfide is still being generated. Sulfides 91-98 chaperonin containing TCP1 subunit 4 Homo sapiens 31-34 29083893-2 2017 Here we explore chemical space to develop a new bicyclic peptide inhibitor, incorporating thioether and lactam linkers that binds with affinity (KD = 1.1 muM) and specificity to the Grb7-SH2 domain. Sulfides 90-99 growth factor receptor bound protein 7 Homo sapiens 182-186 29111705-0 2017 One-Bead-Two-Compound Thioether Bridged Macrocyclic gamma-AApeptide Screening Library against EphA2. Sulfides 22-31 EPH receptor A2 Homo sapiens 94-99 28836374-2 2017 To improve proteolytic stability, intramolecular thioether crosslinks were introduced into a three-helix affibody molecule binding the human epidermal growth factor receptor (EGFR). Sulfides 49-58 epidermal growth factor receptor Homo sapiens 141-173 28972742-7 2017 The EGFR peptide is attached via thioether-mediated conjugation of a GGGSC linker to the maleimide-terminated phospholipids. Sulfides 33-42 epidermal growth factor receptor Homo sapiens 4-8 28864655-2 2017 Some bacteria with sulfide:quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) can oxidize self-produced sulfide to sulfite and thiosulfate, but other bacteria without these enzymes release sulfide into the medium, from which H2S can volatilize into the gas phase. Sulfides 19-26 H16_RS23915 Ralstonia eutropha H16 27-49 28975945-6 2017 Mixed cobalt/nickel sulphide, Co9-xNixS8 ONC, shows superior oxygen evolution reaction activity to monometallic sulphide ONC structures, demonstrating the synergy between different metal species. Sulfides 20-28 phosphoserine phosphatase pseudogene 1 Homo sapiens 30-33 28836374-2 2017 To improve proteolytic stability, intramolecular thioether crosslinks were introduced into a three-helix affibody molecule binding the human epidermal growth factor receptor (EGFR). Sulfides 49-58 epidermal growth factor receptor Homo sapiens 175-179 28786286-4 2017 More importantly, the yielded AgCl signals would decrease selectively induced by sulfides through the specific sulfide-chloride replacement reactions toward the transferring of AgCl into non-electroactive Ag2S. Sulfides 81-89 angiotensin II receptor type 1 Homo sapiens 205-209 28865326-10 2017 Corroborating these findings, silencing of Kelch-like ECH-associated protein 1 (KEAP1), an inhibitor of nuclear factor (erythroid-derived 2)-like 2 (NRF2) nuclear activity, enhanced NQO1 expression, whereas NRF2 silencing reduced the expression of NQO1 and abrogated the calcification-suppressing activity of sulfide. Sulfides 309-316 kelch like ECH associated protein 1 Homo sapiens 43-78 28865326-10 2017 Corroborating these findings, silencing of Kelch-like ECH-associated protein 1 (KEAP1), an inhibitor of nuclear factor (erythroid-derived 2)-like 2 (NRF2) nuclear activity, enhanced NQO1 expression, whereas NRF2 silencing reduced the expression of NQO1 and abrogated the calcification-suppressing activity of sulfide. Sulfides 309-316 kelch like ECH associated protein 1 Homo sapiens 80-85 28865326-10 2017 Corroborating these findings, silencing of Kelch-like ECH-associated protein 1 (KEAP1), an inhibitor of nuclear factor (erythroid-derived 2)-like 2 (NRF2) nuclear activity, enhanced NQO1 expression, whereas NRF2 silencing reduced the expression of NQO1 and abrogated the calcification-suppressing activity of sulfide. Sulfides 309-316 NAD(P)H quinone dehydrogenase 1 Homo sapiens 182-186 28865326-11 2017 Moreover, immunofluorescence microscopy and Western blot analysis confirmed nuclear translocation of NRF2 by sulfide in VSMC. Sulfides 109-116 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 28865326-12 2017 CONCLUSIONS: Sulfide attenuates CPP-induced VSMC calcification in vitro via the KEAP1-NRF2 redox sensing/stress response system by enhancing NQO1 expression. Sulfides 13-20 kelch like ECH associated protein 1 Homo sapiens 80-85 28865326-12 2017 CONCLUSIONS: Sulfide attenuates CPP-induced VSMC calcification in vitro via the KEAP1-NRF2 redox sensing/stress response system by enhancing NQO1 expression. Sulfides 13-20 NFE2 like bZIP transcription factor 2 Homo sapiens 86-90 28865326-12 2017 CONCLUSIONS: Sulfide attenuates CPP-induced VSMC calcification in vitro via the KEAP1-NRF2 redox sensing/stress response system by enhancing NQO1 expression. Sulfides 13-20 NAD(P)H quinone dehydrogenase 1 Homo sapiens 141-145 28937673-4 2017 Here, an asymmetric trifluoromethylthiolation that proceeds through the enantioselective [2,3]-sigmatropic rearrangement of a sulfonium ylide generated from a metal carbene and sulfide (Doyle-Kirmse reaction) has been developed using chiral Rh(II) and Cu(I) catalysts. Sulfides 177-184 Rh blood group D antigen Homo sapiens 241-247 28853748-0 2017 A route to robust thioether-functionalized MOF solid materials displaying heavy metal uptake and the ability to be further oxidized. Sulfides 18-27 lysine acetyltransferase 8 Homo sapiens 43-46 28786286-4 2017 More importantly, the yielded AgCl signals would decrease selectively induced by sulfides through the specific sulfide-chloride replacement reactions toward the transferring of AgCl into non-electroactive Ag2S. Sulfides 81-88 angiotensin II receptor type 1 Homo sapiens 205-209 28624490-3 2017 Sulfide decreased the activities of citrate synthase and aconitase in rat cerebral cortex mitochondria, and of creatine kinase (CK) in rat cerebral cortex, striatum and hippocampus supernatants. Sulfides 0-7 citrate synthase Rattus norvegicus 36-52 28617588-0 2017 Biosynthesis of Single Thioether c-Type Cytochromes Provides Insight into Mechanisms Intrinsic to Holocytochrome c Synthase (HCCS). Sulfides 23-32 holocytochrome c synthase Homo sapiens 98-123 28685879-5 2017 Moreover, a novel 3D framework of [Ga2 PS6 ]- , with triangular-shaped channels, as well as interesting single triangular geometry of AgS3 -both of which are very rare in reported sulfides-was discovered in AgGa2 PS6 . Sulfides 180-188 G protein signaling modulator 1 Homo sapiens 134-138 28685879-5 2017 Moreover, a novel 3D framework of [Ga2 PS6 ]- , with triangular-shaped channels, as well as interesting single triangular geometry of AgS3 -both of which are very rare in reported sulfides-was discovered in AgGa2 PS6 . Sulfides 180-188 taste 2 receptor member 63 pseudogene Homo sapiens 213-216 28970911-4 2017 Complex 7 is likely formed by fast nucleophilic addition of a UV terminal sulfide intermediate, resulting from the slow metathesis reaction of the imido complex with CS2, to a second CS2 molecule. Sulfides 74-81 chorionic somatomammotropin hormone 2 Homo sapiens 166-169 28970911-4 2017 Complex 7 is likely formed by fast nucleophilic addition of a UV terminal sulfide intermediate, resulting from the slow metathesis reaction of the imido complex with CS2, to a second CS2 molecule. Sulfides 74-81 chorionic somatomammotropin hormone 2 Homo sapiens 183-186 28657100-0 2017 Nanocrystalline SnS2 coated onto reduced graphene oxide: demonstrating the feasibility of a non-graphitic anode with sulfide chemistry for potassium-ion batteries. Sulfides 117-124 sodium voltage-gated channel alpha subunit 11 Homo sapiens 16-20 28510292-4 2017 As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2 min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents. Sulfides 331-338 cell adhesion associated, oncogene regulated Homo sapiens 30-33 28510292-4 2017 As a result, the optimized Cd/CdO/CdS heterojunction photoanode showed outstanding and long-term photoelectrochemical activity for water splitting, with a current density of 3.52 mA cm-2 , or a benchmark specific hydrogen production rate of 1.65 mumol cm-2 min-1 at -0.3 V versus Ag/AgCl, by using the environmental pollutants of sulfide and sulfite as sacrificial agents. Sulfides 331-338 CDP-diacylglycerol synthase 1 Homo sapiens 34-37 28687806-0 2017 Morphology Control of Energy-Gap-Engineered Nb2O5 Nanowires and the Regioselective Growth of CdS for Efficient Carrier Transfer Across an Oxide-Sulphide Nanointerface. Sulfides 144-152 CDP-diacylglycerol synthase 1 Homo sapiens 93-96 28790927-2 2017 One of the multiple metabolic functions of CoQ is to transport electrons in the reaction catalyzed by sulfide:quinone oxidoreductase (SQOR), the first enzyme of the oxidation pathway of sulfides (hydrogen sulfide, H2S). Sulfides 102-109 crystallin, zeta Mus musculus 110-132 28790927-2 2017 One of the multiple metabolic functions of CoQ is to transport electrons in the reaction catalyzed by sulfide:quinone oxidoreductase (SQOR), the first enzyme of the oxidation pathway of sulfides (hydrogen sulfide, H2S). Sulfides 186-194 crystallin, zeta Mus musculus 110-132 28592682-11 2017 In the lens, the most abundant cross-link involved Cys5 of betaA4 crystallin attached via a thioether bond to glutathione. Sulfides 92-101 crystallin beta A4 Homo sapiens 59-76 28617588-0 2017 Biosynthesis of Single Thioether c-Type Cytochromes Provides Insight into Mechanisms Intrinsic to Holocytochrome c Synthase (HCCS). Sulfides 23-32 holocytochrome c synthase Homo sapiens 125-129 28617588-2 2017 Most eukaryotes use the System III cyt c biogenesis pathway composed of holocytochrome c synthase (HCCS) to catalyze thioether formation. Sulfides 117-126 holocytochrome c synthase Homo sapiens 72-97 28617588-2 2017 Most eukaryotes use the System III cyt c biogenesis pathway composed of holocytochrome c synthase (HCCS) to catalyze thioether formation. Sulfides 117-126 holocytochrome c synthase Homo sapiens 99-103 28617588-4 2017 Previous studies have shown that recombinant HCCS can produce low levels of the XXXCH single thioether variant. Sulfides 93-102 holocytochrome c synthase Homo sapiens 45-49 28444344-6 2017 We generated GapC1-green fluorescent protein (GFP) and GapC2-GFP transgenic plants in both the wild type and the des1 mutant defective in the l-cysteine desulfhydrase DES1, responsible for the generation of sulfide in the cytosol. Sulfides 207-214 glyceraldehyde-3-phosphate dehydrogenase C2 Arabidopsis thaliana 55-60 28498557-2 2017 Herein, we report the first high-yield preparation of solution-processed ultrathin 2D metal oxide/sulfide hybrid nanosheets, that is, Tix Ta1-x Sy Oz (x=0.71, 0.49, and 0.30), from Tix Ta1-x S2 precursors. Sulfides 98-105 trace amine associated receptor 1 Homo sapiens 138-141 28589933-0 2017 Towards colloidal spintronics through Rashba spin-orbit interaction in lead sulphide nanosheets. Sulfides 76-84 spindlin 1 Homo sapiens 18-22 28589933-2 2017 Here, in order to benefit from both concepts, we investigate Rashba spin-orbit interaction in colloidal lead sulphide nanosheets by electrical measurements on the circular photo-galvanic effect. Sulfides 109-117 spindlin 1 Homo sapiens 68-72 28485576-9 2017 The C10 tag can also be attached to cysteine residues in proteins, where it generates a stable thioether bond. Sulfides 95-104 homeobox C10 Homo sapiens 4-7 28485576-9 2017 The C10 tag can also be attached to cysteine residues in proteins, where it generates a stable thioether bond. Sulfides 95-104 long intergenic non-protein coding RNA 1194 Homo sapiens 8-11 28444344-6 2017 We generated GapC1-green fluorescent protein (GFP) and GapC2-GFP transgenic plants in both the wild type and the des1 mutant defective in the l-cysteine desulfhydrase DES1, responsible for the generation of sulfide in the cytosol. Sulfides 207-214 L-cysteine desulfhydrase 1 Arabidopsis thaliana 113-117 28444344-6 2017 We generated GapC1-green fluorescent protein (GFP) and GapC2-GFP transgenic plants in both the wild type and the des1 mutant defective in the l-cysteine desulfhydrase DES1, responsible for the generation of sulfide in the cytosol. Sulfides 207-214 L-cysteine desulfhydrase 1 Arabidopsis thaliana 167-171 28302398-1 2017 LuxS (S-ribosylhomocysteinase; EC 4.4.1.21) is an enzyme that catalyzes the cleavage of the thioether linkage in the catalytic pathway of S-ribosylhomocysteine (SRH) which produces homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD). Sulfides 92-101 Lutheran suppressor, X-linked Homo sapiens 0-4 28411626-5 2017 In the case of plasma proteins, this novel combined detection assay revealed that approximately 14.7, 1.7, 3.9, 3.7 sulfide mol/mol released from human serum albumin, alpha1-anti-trypsin, alpha1-acid glycoprotein and ovalbumin, respectively, suggesting that serum albumin is a major pool of polysulfide in human blood circulation. Sulfides 116-123 adrenoceptor alpha 1D Homo sapiens 188-194 28615947-8 2017 Etelcalcetide binds directly to CaSR, by a sulfide bond, inhibiting the production and secretion of PTH by parathyroid glands. Sulfides 43-50 calcium sensing receptor Homo sapiens 32-36 28615947-8 2017 Etelcalcetide binds directly to CaSR, by a sulfide bond, inhibiting the production and secretion of PTH by parathyroid glands. Sulfides 43-50 parathyroid hormone Homo sapiens 100-103 28593139-3 2017 The two cysteine sulfhydryls of Cygb were modified to form either an intramolecular disulfide bond (Cygb_SS), thioether bonds to N-ethylmaleimide (NEM; Cygb_SC), or were maintained as free SH groups (Cygb_SH). Sulfides 110-119 cytoglobin Homo sapiens 32-36 28131038-6 2017 Synthesized SeS2 was formed mixing a sulfide solution and effluent containing selenite. Sulfides 37-44 secernin 2 Homo sapiens 12-16 28060514-5 2017 Here we report the design of a peptide-based antagonist (a reactive peptide) that specifically binds to Grb2N-SH3 and subsequently undergoes a nucleophilic reaction with Cys32 to form a covalent bond thioether, to block Grb2-Sos1 interaction. Sulfides 200-209 growth factor receptor bound protein 2 Homo sapiens 104-113 28060514-5 2017 Here we report the design of a peptide-based antagonist (a reactive peptide) that specifically binds to Grb2N-SH3 and subsequently undergoes a nucleophilic reaction with Cys32 to form a covalent bond thioether, to block Grb2-Sos1 interaction. Sulfides 200-209 growth factor receptor bound protein 2 Homo sapiens 104-108 28060514-5 2017 Here we report the design of a peptide-based antagonist (a reactive peptide) that specifically binds to Grb2N-SH3 and subsequently undergoes a nucleophilic reaction with Cys32 to form a covalent bond thioether, to block Grb2-Sos1 interaction. Sulfides 200-209 SOS Ras/Rac guanine nucleotide exchange factor 1 Homo sapiens 225-229 28246171-10 2017 This study provides mechanistic insights into how the distal heme ligand in neuroglobin caps its reactivity toward H2S and identifies by cryo-mass spectrometry a range of sulfide oxidation products with 2-6 catenated sulfur atoms with or without oxygen insertion, which accumulate in the absence of the His64 ligand. Sulfides 171-178 neuroglobin Homo sapiens 76-87 28402312-3 2017 Upstream, where flow rates were relatively low, dissolved sulfide concentrations around 12 mg S L-1 and hydrogen sulfide gas concentrations above 250 ppm were observed, along with limited corrosion damage. Sulfides 58-65 immunoglobulin kappa variable 1-16 Homo sapiens 96-99 28382204-0 2017 Nitrosopersulfide (SSNO-) decomposes in the presence of sulfide, cyanide or glutathione to give HSNO/SNO-: consequences for the assumed role in cell signalling. Sulfides 10-17 strawberry notch homolog 1 Homo sapiens 20-23 28296393-0 2017 Mechanism of Reduction of Ferric Porphyrins by Sulfide: Identification of a Low Spin FeIII-SH Intermediate. Sulfides 47-54 spindlin 1 Homo sapiens 80-84 28402312-8 2017 Another relevant observation was the rapid decline in dissolved sulfide contents along gravity trunk sewers following the discharge of rising mains, with loss rates as high as 40 mg S L-1 h-1. Sulfides 64-71 immunoglobulin kappa variable 1-16 Homo sapiens 184-187 28196881-1 2017 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). Sulfides 76-85 holocytochrome c synthase Homo sapiens 27-52 28211679-6 2017 To directly compare different coupling strategies, we also produced a BMP2 variant containing an additional cysteine residue (BMP2-A2C) allowing covalent coupling by thioether formation. Sulfides 166-175 bone morphogenetic protein 2 Mus musculus 70-74 28211679-6 2017 To directly compare different coupling strategies, we also produced a BMP2 variant containing an additional cysteine residue (BMP2-A2C) allowing covalent coupling by thioether formation. Sulfides 166-175 bone morphogenetic protein 2 Mus musculus 126-130 27596480-1 2017 The feasibility of NO3- removal by the synergistic action of a prevailing denitrifying anoxic methane oxidising (DAMO), and nitrate-reducing and sulfide-oxidising bacterial (NR-SOB) consortium, using CH4 and H2 S from biogas as electron donors in a biotrickling filter was investigated. Sulfides 145-152 NBL1, DAN family BMP antagonist Homo sapiens 19-22 28196881-1 2017 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). Sulfides 76-85 cytochrome c, somatic Homo sapiens 145-150 28196881-1 2017 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). Sulfides 76-85 holocytochrome c synthase Homo sapiens 258-262 28196881-1 2017 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). Sulfides 76-85 holocytochrome c synthase Homo sapiens 54-58 27957862-4 2017 Furthermore, the ZnS overlayer significantly stabilizes the photocurrent of the CdS/FTO electrode in a polysulfide/sulfide electrolyte solution even under the excitation of CdS (lambda > 430 nm). Sulfides 107-114 CDP-diacylglycerol synthase 1 Homo sapiens 80-83 28222608-4 2017 Representatively, the material (COF-S-SH) synthesized by treating COF-V with 1,2-ethanedithiol exhibits high efficiency in removing mercury from aqueous solutions and the air, affording Hg2+ and Hg0 capacities of 1350 and 863 mg g-1, respectively, surpassing all those of thiol and thioether functionalized materials reported thus far. Sulfides 282-291 ERCC excision repair 6, chromatin remodeling factor Homo sapiens 32-37 28082676-6 2017 Binding of nitric oxide in the reduced Miner2 [2Fe-2S] clusters produces a major absorption peak at 422 nm without releasing iron or sulfide from the clusters. Sulfides 133-140 CDGSH iron sulfur domain 3 Homo sapiens 39-45 29964510-11 2017 The maximum concentrations of iron, manganese, ammonium and sulfide in the summer of the El Nino year were 0.38, 1.36, 2.36 and 1.67 mg L-1, respectively. Sulfides 60-67 immunoglobulin kappa variable 1-16 Homo sapiens 136-139 27957862-4 2017 Furthermore, the ZnS overlayer significantly stabilizes the photocurrent of the CdS/FTO electrode in a polysulfide/sulfide electrolyte solution even under the excitation of CdS (lambda > 430 nm). Sulfides 107-114 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 84-87 27856619-2 2017 One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (SQR), which catalyzes the first reaction in the hydrogen sulfide oxidation pathway. Sulfides 79-86 crystallin, zeta Mus musculus 87-109 28552047-5 2017 T-DM1 is a novel antibody-drug conjugate, combining trastuzumab with a potent cytotoxic, DM1, a maytansine derivative, via a stable thioether linker. Sulfides 132-141 immunoglobulin heavy diversity 1-7 Homo sapiens 2-5 28552047-5 2017 T-DM1 is a novel antibody-drug conjugate, combining trastuzumab with a potent cytotoxic, DM1, a maytansine derivative, via a stable thioether linker. Sulfides 132-141 immunoglobulin heavy diversity 1-7 Homo sapiens 89-92 27871614-9 2016 Repeated analyses of the two proposed sulfide reference materials by LA-MC-ICP-MS yield good external reproducibility of <0.04% (RSD, k = 2) for 20xPb/206Pb and <0.06% (RSD, k = 2) for 20xPb/204Pb with the exception of 20xPb/204Pb in MASS-1, which provided an external reproducibility of 0.24% (RSD, k = 2). Sulfides 38-45 adhesion G protein-coupled receptor V1 Homo sapiens 240-246 28193013-5 2016 In this paper, based on the electrophilic addition of Cl+ to sulfide moiety, we have developed a two-photon fluorescent probe O-(N-butyl-1,8-naphthalimide)-4-yl-N,N-dimethylthiocarbamate (NDMTC) for the specific determination of HOCl over OCl- and other bioactive molecules. Sulfides 61-68 occludin Mus musculus 230-233 27647732-2 2016 Engineered variants of sperm whale myoglobin catalyze this synthetically valuable C-C bond-forming transformation with high efficiency and product conversions across a variety of sulfide substrates (e.g., aryl-, benzyl-, and alkyl-substituted allylic sulfides) and alpha-diazo esters. Sulfides 179-186 myoglobin Physeter catodon 35-44 27611357-3 2016 The results showed that 40mgL-1 of powdered magnetite and hematite addition decreased the sulfide in sewage by 79%and 70%, respectively. Sulfides 90-97 LLGL scribble cell polarity complex component 1 Homo sapiens 26-31 27611357-4 2016 The achieved decrease of sulfide production capacities were 197.3, 210.6, 317.6 and 283.3mgSg-1Fe for magnetite, hematite, FeCl3 and FeSO4 at the optimal dosage of 40mgL-1, respectively. Sulfides 25-32 LLGL scribble cell polarity complex component 1 Homo sapiens 166-171 27806570-0 2016 Staphylococcus aureus sqr Encodes a Type II Sulfide:Quinone Oxidoreductase and Impacts Reactive Sulfur Speciation in Cells. Sulfides 44-51 AT695_RS05530 Staphylococcus aureus 52-74 27806570-2 2016 The cst operon of the major human pathogen Staphylococcus aureus is induced by exogenous H2S stress and encodes enzymes involved in sulfide oxidation, including a group I flavoprotein disulfide oxidoreductase sulfide:quinone oxidoreductase (SQR). Sulfides 132-139 AT695_RS05530 Staphylococcus aureus 217-239 27631174-0 2016 Synthesis of bovine serum albumin-protected high fluorescence Pt16-nanoclusters and their application to detect sulfide ions in solutions. Sulfides 112-119 albumin Homo sapiens 20-33 27654458-4 2016 Our results reveal that the presence of sulfide (7.8-46.9 muM) significantly decreased the breakthrough of ferrihydrite colloids in the sand column. Sulfides 40-47 latexin Homo sapiens 58-61 27791057-3 2016 Our study helps resolve this debate by showing that Pitcairn lavas contain sulfides whose sulfur isotopic compositions are affected by mass-independent fractionation (S-MIF down to Delta33S = -0.8), something which is thought to have occurred on Earth only before 2.45 Ga, constraining the youngest possible age of the EM I source component. Sulfides 75-83 decapping mRNA 1A Homo sapiens 167-172 27859307-1 2016 The sulfide photocatalyst of Zn0.9 Fe0.1 S was successfully synthesized by a facile microwave-assisted method, and Zn0.9 Fe0.1 S photocatalysts were characterized using SEM, EDX, XRD and BET. Sulfides 4-11 delta/notch like EGF repeat containing Homo sapiens 187-190 27704781-5 2016 A concentration-dependent correction is required during data analysis to achieve these specifications, which corrects delta34S measurements for mixing with sulfur native to the film material and fractionation due to Ag2S precipitation from aqueous sulfide. Sulfides 248-255 angiotensin II receptor type 1 Homo sapiens 216-220 27132826-5 2016 GC-MS showed that the total content of furans, pyrroles and thioethers in MRPs Y+M increased by 78.0% compared with MRPs M, while in MRPs Z+F, pyrazines increased by 44.1% compared with MRPs F. Examining the sensory characteristics of the MRPs, the MRP from the hydrolysate of Y+M had the best mouthful, umami and meaty characteristics. Sulfides 60-70 ATP binding cassette subfamily C member 1 Homo sapiens 74-77 27659093-10 2016 When screened against a series of alcohols, thiols, sulfides, and metal-coordinating ligands, OR2T11 responds with enhancement by copper to the mouse semiochemical CH3SCH2SH and derivatives, to four-membered cyclic sulfide thietane and to one- to four-carbon straight- and branched-chain and five-carbon branched-chain thiols but not to longer chain thiols, suggesting compact receptor dimensions. Sulfides 52-60 olfactory receptor family 2 subfamily T member 11 Homo sapiens 94-100 27026547-7 2016 Sulfide SOD accounted for 1.78-45.71 % of the total SOD and it was the secondary predominate of the chemical SOD. Sulfides 0-7 superoxide dismutase 1 Homo sapiens 8-11 27533492-0 2016 Photoelectron Spectroscopy and Ab Initio Calculations of CS3(-) Isomers: Carbon Trisulfide and Carbon Disulfide S-Sulfide Anions. Sulfides 114-121 myozenin 3 Homo sapiens 57-60 27387500-2 2016 HCCS efficiently attaches heme via two thioethers to CXXCH of mitochondrial but not bacterial cyt c even though they are functionally conserved. Sulfides 39-49 holocytochrome c synthase Homo sapiens 0-4 27387500-6 2016 Although an HCCS-WT cyt c complex contains two covalent links, HCCS-DeltaM13 cyt c contains only one thioether attachment. Sulfides 101-110 holocytochrome c synthase Homo sapiens 63-67 26333016-0 2016 Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma. Sulfides 72-81 B-Raf proto-oncogene, serine/threonine kinase Rattus norvegicus 56-61 26803480-5 2016 In addition, we show that the naked mole-rat cystathionine beta-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. Sulfides 156-163 cystathionine beta-synthase Heterocephalus glaber 45-72 26803480-5 2016 In addition, we show that the naked mole-rat cystathionine beta-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. Sulfides 156-163 cystathionine beta-synthase Heterocephalus glaber 74-77 30034725-7 2016 Reactivity studies of the U(iv) sulfide complexes showed that the sulfide is easily transferred to CO2 and CS2 to afford S-functionalized products. Sulfides 32-39 chorionic somatomammotropin hormone 2 Homo sapiens 107-110 30034725-7 2016 Reactivity studies of the U(iv) sulfide complexes showed that the sulfide is easily transferred to CO2 and CS2 to afford S-functionalized products. Sulfides 66-73 chorionic somatomammotropin hormone 2 Homo sapiens 107-110 27310035-5 2016 In this study, we report that myoglobin exhibits a similar capacity for sulfide oxidation. Sulfides 72-79 myoglobin Homo sapiens 30-39 27310035-8 2016 We speculate that the unusual sensitivity of skeletal muscle cytochrome c oxidase to sulfide poisoning in ethylmalonic encephalopathy, resulting from the deficiency in a mitochondrial sulfide oxidation enzyme, might be due to the concentration of H2S by myoglobin in this tissue. Sulfides 85-92 myoglobin Homo sapiens 254-263 27310035-8 2016 We speculate that the unusual sensitivity of skeletal muscle cytochrome c oxidase to sulfide poisoning in ethylmalonic encephalopathy, resulting from the deficiency in a mitochondrial sulfide oxidation enzyme, might be due to the concentration of H2S by myoglobin in this tissue. Sulfides 184-191 myoglobin Homo sapiens 254-263 27026547-7 2016 Sulfide SOD accounted for 1.78-45.71 % of the total SOD and it was the secondary predominate of the chemical SOD. Sulfides 0-7 superoxide dismutase 1 Homo sapiens 52-55 27026547-7 2016 Sulfide SOD accounted for 1.78-45.71 % of the total SOD and it was the secondary predominate of the chemical SOD. Sulfides 0-7 superoxide dismutase 1 Homo sapiens 52-55 27270587-6 2016 Mechanistically, TST selectively augmented mitochondrial function combined with degradation of reactive oxygen species and sulfide. Sulfides 123-130 thiosulfate sulfurtransferase, mitochondrial Mus musculus 17-20 27446049-1 2016 At the Black Sea chemocline, oxygen- and sulfide-rich waters meet and form a niche for thiotrophic pelagic bacteria. Sulfides 41-48 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 13-16 27087315-1 2016 AlbA is a radical SAM enzyme catalyzing the formation of three unusual thioether bonds in the antibiotic subtilosin A. Sulfides 71-80 afamin Homo sapiens 0-4 27285482-4 2016 Herein, we report the design, synthesis, and properties of PAF-1-SMe, a robust three-dimensional porous aromatic framework (PAF) densely functionalized with thioether groups for selective capture and concentration of copper from biofluids as well as aqueous samples. Sulfides 157-166 Paf1, RNA polymerase II complex component Mus musculus 59-64 27087127-7 2016 The keto-1,2,4-oxadiazole functionality with a thioether is a novel structure, and it will be used as a lead to develop inhibitors with higher potency and selectivity toward GVIA iPLA2. Sulfides 47-56 phospholipase A2 group VI Homo sapiens 179-184 27010502-6 2016 These results suggest that sulfides such as 1b, 3b, 4b, and 5b interfere with the binding of p53-Mdmx, resulting in the dissociation of the two proteins. Sulfides 27-35 transformation related protein 53, pseudogene Mus musculus 93-96 27023474-5 2016 The functional mechanism of sulfide in the reaction was identified as in the potential region around -1.071 V (vs Hg/HgO), the outside layer of Fe2O3 was reduced to amorphous FeS, which has good electrical conductivity and enlarges the electrochemical reaction interface. Sulfides 28-35 homogentisate 1,2-dioxygenase Homo sapiens 117-120 27102688-3 2016 METHODS: Mouse monoclonal antibody Zt/g4 (IgG1a/kappa) specific to human RON was conjugated to DM1 via thioether linkage to form Zt/g4-DM1 with a drug-antibody ratio of 4:1. Sulfides 103-112 macrophage stimulating 1 receptor Homo sapiens 73-76 27102688-3 2016 METHODS: Mouse monoclonal antibody Zt/g4 (IgG1a/kappa) specific to human RON was conjugated to DM1 via thioether linkage to form Zt/g4-DM1 with a drug-antibody ratio of 4:1. Sulfides 103-112 DM1 protein kinase Homo sapiens 95-98 27102688-3 2016 METHODS: Mouse monoclonal antibody Zt/g4 (IgG1a/kappa) specific to human RON was conjugated to DM1 via thioether linkage to form Zt/g4-DM1 with a drug-antibody ratio of 4:1. Sulfides 103-112 DM1 protein kinase Homo sapiens 135-138 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 hypoxia inducible factor 1 subunit alpha Homo sapiens 271-281 27548954-6 2016 During the stratification period, the mean concentrations of total nitrogen, total phosphorus, manganese and sulfide were 1.18, 0.11, 0.47 and 0.48 mg L-1, respectively. Sulfides 109-116 immunoglobulin kappa variable 1-16 Homo sapiens 153-156 26969938-5 2016 (+)APCI/CS2 was used to generate stable dominant molecular ions for all the compounds studied except for three sulfides that also showed abundant fragment ions. Sulfides 111-119 chorionic somatomammotropin hormone 2 Homo sapiens 8-11 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 hypoxia inducible factor 1 subunit alpha Homo sapiens 238-269 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 nitric oxide synthase 2 Homo sapiens 331-362 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 nitric oxide synthase 2 Homo sapiens 364-368 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 interleukin 6 Homo sapiens 374-387 26849947-4 2016 Experiments from colonocyte incubation and intra-colonic instillation indicate that low millimolar concentrations of the sulfide donor NaHS reversibly inhibited colonocyte mitochondrial oxygen consumption and increased gene expression of hypoxia inducible factor 1alpha (Hif-1alpha) together with inflammation-related genes namely inducible nitric oxide synthase (iNos) and interleukin-6 (Il-6). Sulfides 121-128 interleukin 6 Homo sapiens 389-393 26482000-4 2015 Complex 3 provided a sensitive measure of sulfide levels in petrochemical water samples (detection limit ~ 250 nM), while complex 1 was capable of monitoring muM levels of sulfide in partially refined crude oil. Sulfides 172-179 latexin Homo sapiens 158-161 26928142-3 2016 In contrast, Saccharomyces cerevisiae thiazole synthase (THI4p) uses an active site cysteine as the sulfide source and is inactivated after a single turnover. Sulfides 100-107 thiamine thiazole synthase Saccharomyces cerevisiae S288C 57-62 26928142-4 2016 Here, we demonstrate that the Thi4 ortholog from Methanococcus jannaschii uses exogenous sulfide and is catalytic. Sulfides 89-96 thiamine thiazole synthase Saccharomyces cerevisiae S288C 30-34 25756468-2 2016 It is a human epidermal growth factor receptor (HER-2)-targeted antibody-drug conjugate composed of trastuzumab, a stable thioether linker, and the potent cytotoxic agent DM1 (derivative of maytansine). Sulfides 122-131 epidermal growth factor receptor Homo sapiens 14-46 25756468-2 2016 It is a human epidermal growth factor receptor (HER-2)-targeted antibody-drug conjugate composed of trastuzumab, a stable thioether linker, and the potent cytotoxic agent DM1 (derivative of maytansine). Sulfides 122-131 erb-b2 receptor tyrosine kinase 2 Homo sapiens 48-53 26794841-3 2016 SbnA is a pyridoxal 5"-phosphate (PLP)-dependent enzyme with homology to O-acetyl-l-serine sulfhydrylases; however, SbnA utilizes OPS instead of O-acetyl-l-serine (OAS), and l-glutamate serves as a nitrogen donor instead of a sulfide. Sulfides 226-233 pyridoxal phosphatase Homo sapiens 34-37 26691536-5 2016 The fluorescence intensity increases linearly with sulfide concentration in the range of 1.0-30 muM with a limit of detection of 52 nM. Sulfides 51-58 latexin Homo sapiens 96-99 26643580-1 2016 The dirhodium(II) carboxylate complex Rh2(esp)2 (esp = alpha,alpha,alpha",alpha"-tetramethyl-1,3-benzenedipropanoate) was shown to catalyze the sulfoxidation of organic sulfides using tert-butyl hydroperoxide as the oxidant. Sulfides 169-177 Rh associated glycoprotein Homo sapiens 38-41 26643580-3 2016 The precipitated Rh2(esp)2-sulfoxide complexes could be reused to catalyze sulfide oxygenation reactions without considerable loss of activity. Sulfides 75-82 Rh associated glycoprotein Homo sapiens 17-20 26318092-1 2016 BACKGROUND: Trastuzumab emtansine (T-DM1), a new agent developed for the treatment of HER2-positive breast cancer, is an antibody-drug conjugate with a complex compound obtained by the conjugation of trastuzumab, a stable thioether linker, and the potent cytotoxic drug maytansine-derivate(DM1), which inhibits cell division and induces cell death. Sulfides 222-231 immunoglobulin heavy diversity 1-7 Homo sapiens 37-40 26240273-3 2015 The fully human anti-RET antibody (Y078) was conjugated to the DM1 and DM4 derivatives of the potent cytotoxic agent maytansine using thioether and disulfide linkers, respectively. Sulfides 134-143 ret proto-oncogene Homo sapiens 21-24 26453916-7 2015 S-sulfuration of GAPDH occurred at Cys 247 after sulfide treatment, Cys 156 and Cys 247 after polysulfide treatment. Sulfides 49-56 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 17-22 26453916-9 2015 Both sulfide and polysulfide was able to restore the activity of glutathione disulfide oxidized GAPDH, but not to control untreated levels. Sulfides 5-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 96-101 26453916-11 2015 Treatment of a C156S mutant of GAPDH with sulfide and polysulfide resulted in S-sulfuration of Cys 152, which also caused a decrease and not an increase in enzymatic activity. Sulfides 42-49 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 31-36 26453916-13 2015 The current study raises significant questions about the reported ability of H2S to activate GAPDH by the sulfuration of its active site thiol, and indicates that polysulfide is a stronger protein S-sulfurating agent than sulfide. Sulfides 167-174 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 93-98 25957834-3 2015 The peptide beacon structure of DP-3 makes it more stable and capable of achieving multianalyte detection, especially for sulfide ions. Sulfides 122-129 APC regulator of WNT signaling pathway Homo sapiens 32-36 26318450-1 2015 The first step in the mitochondrial sulfide oxidation pathway is catalyzed by sulfide quinone oxidoreductase (SQR), which belongs to the family of flavoprotein disulfide oxidoreductases. Sulfides 36-43 crystallin zeta Homo sapiens 86-108 26919468-10 2016 Our recent biochemical studies showed that the archael Thi4 orthologs use nicotinamide adenine dinucleotide, glycine, and free sulfide to form the thiamin thiazole in an iron-dependent reaction [Eser, B., Zhang, X., Chanani, P. K., Begley, T. P., and Ealick, S. E. (2016) J. Sulfides 127-134 thiamine thiazole synthase Saccharomyces cerevisiae S288C 55-59 26982744-6 2016 We observed that those compounds with alterations in the sulfide linker completely lost the Pdcd4 stabilizing potential. Sulfides 57-64 programmed cell death 4 Homo sapiens 92-97 26844296-10 2016 The different persulfide patterns observed in wild-type, GR-null, and TR/GR-null livers suggest distinct roles for the Trx and GSH systems in regulating subsets of protein persulfides and thereby fine-tuning sulfide signaling pathways. Sulfides 17-24 thioredoxin Homo sapiens 119-122 26453916-5 2015 GAPDH in its reduced, or hydrogen peroxide, or glutathione disulfide, or nitrosonium oxidized forms was reacted with sulfide or polysulfides. Sulfides 61-68 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-5 26459212-6 2015 A sulfide analog of PSPC (PSPC-1S) showed no antibacterial activity, whereas the sulfoxide analog (PSPC-6S) showed identical activity as PSPC across all strains, confirming structure-dependent activity for PSPC and suggesting a target-based mechanism of action. Sulfides 2-9 surfactant protein C Homo sapiens 20-24 26546573-9 2015 We discovered that an SLC13 family protein, sodium sulfate cotransporter 2 (SLC13A4, NaS-2), facilitates transport of thiosulfate, but not sulfide, across the cell membrane, regulating intracellular concentrations and thus mediating cytoprotective effects of Na2S and STS. Sulfides 139-146 solute carrier family 13 member 4 Homo sapiens 76-83 26546573-9 2015 We discovered that an SLC13 family protein, sodium sulfate cotransporter 2 (SLC13A4, NaS-2), facilitates transport of thiosulfate, but not sulfide, across the cell membrane, regulating intracellular concentrations and thus mediating cytoprotective effects of Na2S and STS. Sulfides 139-146 solute carrier family 13 member 4 Homo sapiens 85-90 26404539-1 2015 This study presents thioether construction involving alkyl/aryl thiosulfates and diazonium salt catalyzed by visible-light-excited [Ru(bpy)3 Cl2 ] at room temperature in 44-86 % yield. Sulfides 20-29 endogenous retrovirus group W member 5 Homo sapiens 141-144 24990521-5 2015 Another member of the OASTL family is DES1, a novel L-cysteine desulfhydrase that catalyzes the desulfuration of Cys to produce sulfide, thus acting in a manner opposite to that of OAS-A1. Sulfides 128-135 L-cysteine desulfhydrase 1 Arabidopsis thaliana 38-42 26384744-1 2015 The oxidation of thioethers by the green oxidant aqueous H2 O2 catalysed by the tetratitanium-substituted Polyoxometalate (POM) (Bu4 N)8 [{gamma-SiTi2 W10 O36 (OH)2 }2 (mu-O)2 ], as a model catalyst comprising tetrameric titanium centres, was investigated by kinetic modelling and DFT calculations. Sulfides 17-27 adaptor related protein complex 1 subunit mu 2 Homo sapiens 139-175 24990521-6 2015 Detailed studies of the oas-a1 and des1 null mutants have revealed the involvement of the DES1 and OAS-A1 proteins in coordinate regulation of Cys homeostasis and the generation of sulfide in the cytosol for signaling purposes. Sulfides 181-188 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 24-30 24990521-6 2015 Detailed studies of the oas-a1 and des1 null mutants have revealed the involvement of the DES1 and OAS-A1 proteins in coordinate regulation of Cys homeostasis and the generation of sulfide in the cytosol for signaling purposes. Sulfides 181-188 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 99-105 24990521-6 2015 Detailed studies of the oas-a1 and des1 null mutants have revealed the involvement of the DES1 and OAS-A1 proteins in coordinate regulation of Cys homeostasis and the generation of sulfide in the cytosol for signaling purposes. Sulfides 181-188 L-cysteine desulfhydrase 1 Arabidopsis thaliana 35-39 24990521-6 2015 Detailed studies of the oas-a1 and des1 null mutants have revealed the involvement of the DES1 and OAS-A1 proteins in coordinate regulation of Cys homeostasis and the generation of sulfide in the cytosol for signaling purposes. Sulfides 181-188 L-cysteine desulfhydrase 1 Arabidopsis thaliana 90-94 26837171-7 2015 Thus, a five-membered triazole as the C-3 bioisostere modified with the functionalized side-chain of sulfide-ketone thiosemicarbazone warrants special attention and further investigation. Sulfides 101-109 complement C3 Homo sapiens 38-41 26344591-3 2015 A convincing rationalization was achieved for the highest potent compounds 4 as type II VEGFR-2 inhibitors, based on the simultaneous presence of: (1) the thioether linker and (2) the arylurea moiety in the meta position. Sulfides 155-164 kinase insert domain receptor Homo sapiens 88-95 26194912-5 2015 ETHE1 encodes for a mitochondrial enzyme involved in sulfide detoxification and TYMP for a cytosolic enzyme involved in the thymidine/deoxyuridine catabolic pathway. Sulfides 53-60 ETHE1 persulfide dioxygenase Homo sapiens 0-5 26135639-3 2015 Given that the nitrogenase active site uses weak-field sulfide ligands to stabilize its reactive Fe center(s), N2 binding to high-spin Fe is of great interest. Sulfides 55-62 spindlin 1 Homo sapiens 130-134 26269602-10 2015 Thiosulfate-dependent H2S production in murine liver lysate is low, consistent with a role for rhodanese in sulfide oxidation. Sulfides 108-115 thiosulfate sulfurtransferase, mitochondrial Mus musculus 95-104 26308392-3 2015 Here, we show that carbon disulfide (CS2), a component of volcanic emission and sulfide mineral weathering, and a widely used synthetic reagent and solvent, promotes peptide bond formation in modest yields (up to ~20%) from alpha-amino acids under mild aqueous conditions. Sulfides 28-35 chorionic somatomammotropin hormone 2 Homo sapiens 37-40 26365764-5 2015 Although the initial aim was to improve electrocatalytic activity by greatly boosting the active area of the Ni-S catalyst, the performance enhancements instead were found to arise primarily from the ability of the proton-conductive MOF to favourably modify the immediate chemical environment of the sulfide-based catalyst. Sulfides 300-307 solute carrier family 5 member 5 Homo sapiens 109-113 26005785-10 2015 Overall, this study highlights that sediments impacted by STP discharges can become local hot-spots for Hg methylation due to the combined inputs of i) Hg, ii) organic matter, which fuels bacterial activities and iii) iron, which keeps porewater sulfide concentration low and hence Hg bioavailable. Sulfides 246-253 thyroid hormone receptor interactor 10 Homo sapiens 58-61 26163932-2 2015 After the reaction of sulfide ions with LN1 or L1 aiming at the formation of the corresponding thiopyrylium derivatives LN3 or L3, they were separated on a C18 column using phosphate buffer and acetonitrile as eluent, and afterwards detected with a UV/vis detector. Sulfides 22-29 phytanoyl-CoA 2-hydroxylase Homo sapiens 40-43 26163932-3 2015 By using the described method, sulfide ions can be determined in the range of 5.12-486.4 mug L(-1) or 1.024-20.48 mug L(-1) by means of L1 or LN1, respectively. Sulfides 31-38 phytanoyl-CoA 2-hydroxylase Homo sapiens 142-145 29218208-7 2015 The unnatural thioether linkages render the lipids resistant to phospholipase A2 hydrolysis. Sulfides 14-23 phospholipase A2 group IB Homo sapiens 64-80 26257441-1 2015 The metabolic instability of an antitubercular small molecule CD117 was addressed through iterative alteration of a key sulfide substituent and interrogation of the effect on growth inhibition of cultured Mycobacterium tuberculosis. Sulfides 120-127 KIT proto-oncogene receptor tyrosine kinase Mus musculus 62-67 25846942-2 2015 An attractive methodology, single-electron transfer (SET) reductive cleavage of the C-S bond mediated by a metal in the presence of the external stimuli PPh3, has been applied to the kinetically inert IrCl3 in order to synthesize the thiolato complex [Ir(III)(L(S))Cl(PPh3)2] 3 from precursor thioether complexes [Ir(III)(L(SR))Cl2(PPh3)] (R = alkyl) 2. Sulfides 293-302 caveolin 1 Homo sapiens 153-157 25874809-2 2015 Three mechanistic pathways are proposed for the inactivation of neuronal NOS (nNOS) by (S)-2-amino-5-(2-(methylthio)acetimidamido)pentanoic acid (1): sulfide oxidation, oxidative dethiolation, and oxidative demethylation. Sulfides 150-157 nitric oxide synthase 1 Homo sapiens 64-76 26353475-0 2015 Antineoplastic Activity Comparison of Bovine Serum Albumin--Conjugated Sulfides Semiconductor Nanomaterials. Sulfides 71-79 albumin Homo sapiens 45-58 25874809-2 2015 Three mechanistic pathways are proposed for the inactivation of neuronal NOS (nNOS) by (S)-2-amino-5-(2-(methylthio)acetimidamido)pentanoic acid (1): sulfide oxidation, oxidative dethiolation, and oxidative demethylation. Sulfides 150-157 nitric oxide synthase 1 Homo sapiens 78-82 25947166-11 2015 CONCLUSIONS: This study provides new insight into the regulation of sulfur metabolism in wine yeasts and identifies variants of MET2 and SKP2 genes, that control the activity of both branches of the sulfur amino acid synthesis pathway and modulate sulfite/sulfide production and other related phenotypes. Sulfides 256-263 homoserine O-acetyltransferase Saccharomyces cerevisiae S288C 128-132 25947166-11 2015 CONCLUSIONS: This study provides new insight into the regulation of sulfur metabolism in wine yeasts and identifies variants of MET2 and SKP2 genes, that control the activity of both branches of the sulfur amino acid synthesis pathway and modulate sulfite/sulfide production and other related phenotypes. Sulfides 256-263 putative SCF ubiquitin ligase complex subunit SKP2 Saccharomyces cerevisiae S288C 137-141 25987843-3 2015 CS2 and other associated sulfide compounds were found by this study to be present in emissions from unconventional shale gas extraction and processing (E&P) operations. Sulfides 25-32 chorionic somatomammotropin hormone 2 Homo sapiens 0-3 25892069-2 2015 The change in colour measured from the image of the disposable membrane acquired by a digital camera using the H coordinate of the HSV colour space as the analytical parameter is able to sense sulphide in aqueous solution at pH 7.4 with a dynamic range up to 145 muM, a detection limit of 0.10 muM and a precision between 2 and 11%. Sulfides 193-201 latexin Homo sapiens 263-266 25892069-2 2015 The change in colour measured from the image of the disposable membrane acquired by a digital camera using the H coordinate of the HSV colour space as the analytical parameter is able to sense sulphide in aqueous solution at pH 7.4 with a dynamic range up to 145 muM, a detection limit of 0.10 muM and a precision between 2 and 11%. Sulfides 193-201 latexin Homo sapiens 294-297 25596185-2 2015 Mutations to the hETHE1 gene compromise sulfide metabolism leading to the genetic disease ethylmalonic encephalopathy. Sulfides 40-47 ETHE1 persulfide dioxygenase Homo sapiens 17-23 26285330-4 2015 RESULTS: The application of the sulfide-containing siltypeloids was shown to have positive clinical effect on the adrenal and ovarian function and to exert the modulating action on the levels of the pituitary and sex hormones in women with bacterial vaginosis and normal prolactin levels. Sulfides 32-39 prolactin Homo sapiens 271-280 25433282-12 2015 In the nonrecovery arm, there was a reduction in serum levels of tumor necrosis factor alpha in sulfide-treated animals compared with controls (909 +- 98 vs. 607 +- 159 pg/mL; P = 0.0038). Sulfides 96-103 tumor necrosis factor Rattus norvegicus 65-92 26005542-5 2015 The thioether analogues were the most potent SIRT2 inhibitors with a two- to three-fold increase in potency relative to their corresponding sulfonamide analogues. Sulfides 4-13 sirtuin 2 Rattus norvegicus 45-50 25646854-0 2015 Development of cyclic NGR peptides with thioether linkage: structure and dynamics determining deamidation and bioactivity. Sulfides 40-49 reticulon 4 receptor Homo sapiens 22-25 25646854-2 2015 Here we report the synthesis and structural analysis of novel thioether bond-linked cyclic NGR peptides. Sulfides 62-71 reticulon 4 receptor Homo sapiens 91-94 25688092-7 2015 An NADPH/flavoprotein oxidoreductase system restores polysulfide-carrying hemoglobin derivatives to ferrous hemoglobin, thus completing the methemoglobin-dependent sulfide oxidation cycle. Sulfides 57-64 hemoglobin subunit gamma 2 Homo sapiens 140-153 25688092-8 2015 Methemoglobin-dependent sulfide oxidation in mammals is complex and has similarities to chemistry reported for the dissolution of iron oxides in sulfidic waters and during bioleaching of metal sulfides. Sulfides 24-31 hemoglobin subunit gamma 2 Homo sapiens 0-13 28787992-4 2015 CS2 sulfurization is an appropriate method for preparing sulfide thermoelectric materials. Sulfides 57-64 chorionic somatomammotropin hormone 2 Homo sapiens 0-3 25635761-5 2015 Activities of alcohol dehydrogenase and cytochrome c oxidase were both reduced by increasing sulfide concentration, but cytochrome c oxidase was more sensitive to sulfide compared to alcohol dehydrogenase. Sulfides 93-100 aldo-keto reductase family 1 member A1 Homo sapiens 14-35 25635761-5 2015 Activities of alcohol dehydrogenase and cytochrome c oxidase were both reduced by increasing sulfide concentration, but cytochrome c oxidase was more sensitive to sulfide compared to alcohol dehydrogenase. Sulfides 163-170 aldo-keto reductase family 1 member A1 Homo sapiens 14-35 25635761-6 2015 Activities of cytochrome c oxidase were reduced to near zero at 5-10 muM sulfide whereas alcohol dehydrogenase activities were only reduced by about 50% at 10 muM sulfide. Sulfides 163-170 aldo-keto reductase family 1 member A1 Homo sapiens 89-110 24833283-5 2015 Two emissions related to zinc and sulfide ion vacancies were observed for the Znx Cd1-x S/alginate core/shell nanoparticles due to the surface changes from the alginate coating. Sulfides 34-41 CD1c molecule Homo sapiens 82-85 25086278-1 2015 Glutathione S-transferases (GSTs), are a family of enzymes belonging to the phase II metabolism that catalyse the formation of thioether conjugates between the endogenous tripeptide glutathione and xenobiotic compounds. Sulfides 127-136 glutathione S-transferase kappa 1 Homo sapiens 28-32 25416292-9 2015 Synthesis of cysteine in the cytosol was found to be particularly important for accumulation of sulfite, sulfate and thiosulfate, indicating an important role for cytosolic OAS-TL for the re-oxidation of sulfide. Sulfides 204-211 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 173-179 25511501-8 2015 More importantly, the (202)Hg signal intensity produced in the sulfide standard MASS-1 by laser ablation is reduced from 256 to 0.7 mV by the use of the wave signal-smoothing and mercury-removing device. Sulfides 63-70 adhesion G protein-coupled receptor V1 Homo sapiens 80-86 25725526-1 2015 The first step in the mammalian metabolism of H2S is catalyzed by sulfide:quinone oxidoreductase (SQOR). Sulfides 66-73 crystallin zeta Homo sapiens 74-96 25487639-0 2015 Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation. Sulfides 0-9 TNF receptor superfamily member 10b Homo sapiens 67-83 25487639-6 2015 The same holds true for dimeric versions of these peptides: the thioether is able to induce DR5-mediated apoptosis of BJAB lymphoma and tumorigenic BJELR cells, albeit to a slightly lower extent compared to its disulfide homologue. Sulfides 64-73 TNF receptor superfamily member 10b Homo sapiens 92-95 25747485-5 2015 Two enzymes have been recently described to catalyze sulfide detoxification in mitochondria of Arabidopsis thaliana, O-acetylserine(thiol)lyase C (OAS-TL C), and the sulfur dioxygenase (SDO) ethylmalonic encephalopathy protein 1 (ETHE1). Sulfides 53-60 glyoxalase II 3 Arabidopsis thaliana 191-228 25747485-5 2015 Two enzymes have been recently described to catalyze sulfide detoxification in mitochondria of Arabidopsis thaliana, O-acetylserine(thiol)lyase C (OAS-TL C), and the sulfur dioxygenase (SDO) ethylmalonic encephalopathy protein 1 (ETHE1). Sulfides 53-60 glyoxalase II 3 Arabidopsis thaliana 230-235 25597503-5 2015 Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release. Sulfides 109-116 iron-sulfur cluster assembly enzyme Homo sapiens 40-44 25597503-5 2015 Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release. Sulfides 109-116 frataxin Homo sapiens 46-54 25597503-5 2015 Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release. Sulfides 109-116 NFS1 cysteine desulfurase Homo sapiens 101-105 25630260-3 2015 Experiments with several blockers of cystathionine gamma-lyase (CSE), the enzyme responsible for sulphide synthesis in the vasculature, demonstrated that propargylglycine (PAG, 1 mm) had little or no effect on the NPV caused by PGF2alpha or LY83583. Sulfides 97-105 cystathionine gamma-lyase Rattus norvegicus 37-62 25630260-3 2015 Experiments with several blockers of cystathionine gamma-lyase (CSE), the enzyme responsible for sulphide synthesis in the vasculature, demonstrated that propargylglycine (PAG, 1 mm) had little or no effect on the NPV caused by PGF2alpha or LY83583. Sulfides 97-105 cystathionine gamma-lyase Rattus norvegicus 64-67 25630260-9 2015 Application of a combination of 1 mm cysteine and 1 mm alpha-ketoglutarate to promote sulphide synthesis via the cysteine aminotransferase/mercaptopyruvate sulphurtransferase (CAT/MST) pathway caused an increase in HPV similar to that observed for cysteine. Sulfides 86-94 catalase Rattus norvegicus 176-183 25630260-13 2015 The results provide evidence that the sulphide precursor cysteine can promote both NPV and HPV in rat IPA by generating sulphide via a PAG-sensitive pathway, presumably CSE. Sulfides 38-46 cystathionine gamma-lyase Rattus norvegicus 169-172 25725526-1 2015 The first step in the mammalian metabolism of H2S is catalyzed by sulfide:quinone oxidoreductase (SQOR). Sulfides 66-73 sulfide quinone oxidoreductase Homo sapiens 98-102 25140352-1 2014 Two fluorescent probes, m-PSP and p-PSP , for sulfite and/or sulfide were constructed by connecting a pyridinium ion to a coumarin fluorophore through an alpha,beta-unsaturated ketone. Sulfides 61-68 microseminoprotein beta Homo sapiens 26-29 25462758-1 2015 Nitrate (NO3-) is commonly dosed in sewer systems to reduce sulfide (H2S) and methane (CH4) produced in anaerobic rising main pipes. Sulfides 60-67 NBL1, DAN family BMP antagonist Homo sapiens 9-12 25280088-4 2014 Halothioether species initially form, ionize in the presence (low dielectric media) or absence (higher dielectric media) of the nucleophile, and react through SN2-like transition structures (TS A and D), where the alpha-alkoxy group is gauche to the thioether moiety. Sulfides 4-13 hexosaminidase subunit alpha Homo sapiens 191-201 25348393-0 2014 Sulfate reduction and sulfide oxidation in extremely steep salinity gradients formed by freshwater springs emerging into the Dead Sea. Sulfides 22-29 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 130-133 25348393-5 2014 Thus, sulfide from the springs, locally reduced salinity and O2 from the Dead Sea water are responsible for the abundant microbial biomass around the springs. Sulfides 6-13 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 78-81 25225291-2 2014 Yet despite its significance, fundamental questions regarding how the sulfide oxidation pathway is wired remain unanswered, and competing proposals exist that diverge at the very first step catalyzed by sulfide quinone oxidoreductase (SQR). Sulfides 70-77 crystallin zeta Homo sapiens 211-233 25281270-3 2014 We designed three NQO1-targeted radioiodinated compounds including two ether linkage compounds ([(125)I]1 and [(125)I]2) and a sulfide linkage compound ([(125)I]3) based on the selective binding of indolequinone analogs to the active site of NQO1 by the stacking effect. Sulfides 127-134 NAD(P)H quinone dehydrogenase 1 Homo sapiens 18-22 25127594-4 2014 The hydrolytic activity of cysteine protease was inhibited by taking advantage of sulfide, the characteristic metabolic product of SRB, to attack active cysteine thiol group in cysteine protease catalytic sites. Sulfides 82-89 cathepsin B Homo sapiens 27-44 25127594-4 2014 The hydrolytic activity of cysteine protease was inhibited by taking advantage of sulfide, the characteristic metabolic product of SRB, to attack active cysteine thiol group in cysteine protease catalytic sites. Sulfides 82-89 cathepsin B Homo sapiens 177-194 25140352-1 2014 Two fluorescent probes, m-PSP and p-PSP , for sulfite and/or sulfide were constructed by connecting a pyridinium ion to a coumarin fluorophore through an alpha,beta-unsaturated ketone. Sulfides 61-68 microseminoprotein beta Homo sapiens 36-39 25140352-4 2014 The detection limits of m-PSP for the analysis of sulfite and sulfide are calculated to 8.5 x 10(-7) M and 2.7 x 10(-7) M, respectively. Sulfides 62-69 microseminoprotein beta Homo sapiens 26-29 25170082-9 2014 Three roles for His-19 in HCCS-mediated assembly are suggested: (i) to provide the second axial ligand to the heme iron in preparation for covalent attachment; (ii) to spatially position the two cysteinyl sulfurs adjacent to the two heme vinyl groups for thioether formation; and (iii) to aid in release of the holocytochrome c from the HCCS active site. Sulfides 255-264 holocytochrome c synthase Homo sapiens 26-30 25170082-1 2014 Mitochondrial cytochrome c assembly requires the covalent attachment of heme by thioether bonds between heme vinyl groups and a conserved CXXCH motif of cytochrome c/c1. Sulfides 80-89 cytochrome c, somatic Homo sapiens 14-26 25064158-13 2014 However, sulfide production enhanced CdS QDs biosynthesis. Sulfides 9-16 CDP-diacylglycerol synthase 1 Homo sapiens 37-40 25298227-2 2014 Mechanistic studies suggest a single catalyst, derived from Pd(dba)2 and NiXantPhos, efficiently catalyzes alpha-arylation of sulfides, C-S bond cleavage, and C-S bond formation in a tricatalytic cycle. Sulfides 126-134 DBA2 Homo sapiens 60-68 25264825-0 2014 Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. Sulfides 65-72 phosphodiesterase 7A Homo sapiens 78-82 24928562-3 2014 However, in contrast with NO or CO, sulfide at concentrations lower than the toxic (muM) level is an hydrogen donor and a substrate for mitochondrial respiration. Sulfides 36-43 latexin Homo sapiens 84-87 25212264-9 2014 Robust Principal Component Analysis operated on log-transformed elemental concentrations showed components indicative of a) sulfides ore minerals (PC1) reflecting the influence of the diffuse mineralization covering the entire study area, b) the presence of some bioavailable As sources (PC2) as As-rich pyrite and Fe-containing sphalerite and c) other sources of metals overlapping the diffuse mineralizations, as carbonate rocks and coal deposits (PC3). Sulfides 124-132 proprotein convertase subtilisin/kexin type 1 Homo sapiens 147-150 25198162-1 2014 ETHE1 is an iron-containing protein from the metallo beta-lactamase family involved in the mitochondrial sulfide oxidation pathway. Sulfides 105-112 ETHE1 persulfide dioxygenase Homo sapiens 0-5 25198162-2 2014 Mutations in ETHE1 causing loss of function result in sulfide toxicity and in the rare fatal disease Ethylmalonic Encephalopathy (EE). Sulfides 54-61 ETHE1 persulfide dioxygenase Homo sapiens 13-18 25076060-0 2014 Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim. Sulfides 31-38 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 74-79 24766186-5 2014 Anti-neuropilin-1 immunoliposomes were prepared by covalently conjugating Fab" fragments of neuropilin-1 antibody to functionalised PEGylated liposomes via thioether linkage. Sulfides 156-165 neuropilin 1 Homo sapiens 5-17 24410953-1 2014 ETHYLMALONIC ENCEPHALOPATHY PROTEIN 1 (ETHE1) encodes sulfur dioxygenase (SDO) activity regulating sulfide levels in living organisms. Sulfides 99-106 ETHE1 persulfide dioxygenase Homo sapiens 39-44 25158856-7 2014 LanCL1 protein purified from eukaryotic cells catalyzes the formation of thioether products similar to glutathione S-transferase. Sulfides 73-82 LanC like 1 Homo sapiens 0-6 25076060-0 2014 Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim. Sulfides 31-38 BCL2 like 11 Homo sapiens 113-116 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 90-95 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 BCL2 like 11 Homo sapiens 96-99 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 BCL2 like 1 Homo sapiens 104-110 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 BCL2 like 11 Homo sapiens 111-114 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 263-268 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 BCL2 like 11 Homo sapiens 111-114 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 BCL2 like 1 Homo sapiens 278-284 24987017-1 2014 Sulfite reductase (SiR) is an essential enzyme of the sulfate assimilation reductive pathway, which catalyzes the reduction of sulfite to sulfide. Sulfides 138-145 sulfite reductase Solanum lycopersicum 0-17 25076060-4 2014 Benzyl- and benzyl methoxy-containing sulfide derivatives 4 and 5 were highly potent dual Mcl-1/Bim and Bcl-xL/Bim disruptors (IC50 values of 600 and 700 nM), whereas carboxylate-containing sulfide derivative 9 exhibited 16.4-fold more selectivity for disrupting Mcl-1/Bim over Bcl-xL/Bim binding. Sulfides 38-45 BCL2 like 11 Homo sapiens 111-114 24987017-1 2014 Sulfite reductase (SiR) is an essential enzyme of the sulfate assimilation reductive pathway, which catalyzes the reduction of sulfite to sulfide. Sulfides 138-145 sulfite reductase Solanum lycopersicum 19-22 24929290-0 2014 Inhibition of 17beta-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker. Sulfides 123-132 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 14-25 24114174-10 2014 Our results suggest that sulfide signaling plays a role in regulation of the NCX1, beta1 and beta3 adrenergic receptors, their co-localization, and stimulation of apoptosis, which might be of a potential importance in cancer treatment. Sulfides 25-32 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 83-88 24967680-1 2014 Cleavage of the thioether bond of S-D-ribosyl-L-homocysteine (SRH) by the enzyme S-ribosylhomocysteinase (LuxS) serves as the final biosynthetic step in the generation of the quorum sensing autoinducer AI-2 by bacteria. Sulfides 16-25 Lutheran suppressor, X-linked Homo sapiens 106-110 24631867-2 2014 Their biosynthesis relies on a complex post-translational process, called cytochrome c biogenesis, responsible for the formation of stereo-specific thioether bonds between the vinyl groups of heme b (protoporphyrin IX-Fe) and the thiol groups of apocytochromes c heme-binding site (C1XXC2H) cysteine residues. Sulfides 148-157 cytochrome c, somatic Homo sapiens 74-86 24114174-10 2014 Our results suggest that sulfide signaling plays a role in regulation of the NCX1, beta1 and beta3 adrenergic receptors, their co-localization, and stimulation of apoptosis, which might be of a potential importance in cancer treatment. Sulfides 25-32 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 99-119 24114174-0 2014 Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the beta1 and beta3 but not beta2 adrenergic receptors, and induces apoptosis. Sulfides 43-50 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 85-100 24437386-7 2014 Employing alpha-globin as a model substrate, we demonstrate the facile conjugation to K48-linked ubiquitin chains, bearing up to four ubiquitins, through disulfide and thioether linkages. Sulfides 168-177 hemoglobin subunit alpha 2 Homo sapiens 10-22 24114174-3 2014 Thus, the aims of our work were to determine effect of sulfide signaling on the NCX type 1 (NCX1) expression and function in HeLa cells, to investigate the relationship of beta-adrenergic receptors with the NCX1 in the presence and/or absence of H2S, and to determine physiological importance of this potential communication. Sulfides 55-62 solute carrier family 8 member A1 Homo sapiens 80-90 24114174-3 2014 Thus, the aims of our work were to determine effect of sulfide signaling on the NCX type 1 (NCX1) expression and function in HeLa cells, to investigate the relationship of beta-adrenergic receptors with the NCX1 in the presence and/or absence of H2S, and to determine physiological importance of this potential communication. Sulfides 55-62 solute carrier family 8 member A1 Homo sapiens 92-96 24114174-10 2014 Our results suggest that sulfide signaling plays a role in regulation of the NCX1, beta1 and beta3 adrenergic receptors, their co-localization, and stimulation of apoptosis, which might be of a potential importance in cancer treatment. Sulfides 25-32 solute carrier family 8 member A1 Homo sapiens 77-81 24413529-4 2014 The tripodal thioether forms [AlCl3{MeC(CH2SMe)3}], which is a chain polymer with kappa(2)-coordinated ligand and a tbp arrangement at Al(iii). Sulfides 13-22 TATA-box binding protein Homo sapiens 116-119 24792433-2 2014 It has been linked to expansion of a GAA-triplet repeat in the first intron of the FXN gene, leading to a reduced level of frataxin, a mitochondrial protein which, by controlling both iron entry and/or sulfide production, is essential to properly assemble and protect the Fe-S cluster during the initial stage of biogenesis. Sulfides 202-209 frataxin Homo sapiens 83-86 24792433-2 2014 It has been linked to expansion of a GAA-triplet repeat in the first intron of the FXN gene, leading to a reduced level of frataxin, a mitochondrial protein which, by controlling both iron entry and/or sulfide production, is essential to properly assemble and protect the Fe-S cluster during the initial stage of biogenesis. Sulfides 202-209 frataxin Homo sapiens 123-131 24533466-7 2014 The presence of sulfide ions in the rock-salt structure alters the band structure and creates a plateau in the electrical conductivity and thermopower from 600 to 800 K giving a power factor of 27 muW/cmK(2). Sulfides 16-23 C-X-C motif chemokine ligand 9 Homo sapiens 201-206 24717654-4 2014 This sensor responded linearly to sulfide in the range of 50 nM to 8 muM, and was capable of detecting sulfide as low as 5.5 nM. Sulfides 34-41 latexin Homo sapiens 69-72 24285094-3 2014 Cysteine is synthesized during the sulfate assimilation pathway via the incorporation of sulfide to O-acetylserine, catalyzed by O-acetylserine(thiol)lyase (OASTL). Sulfides 89-96 cysteine synthase 26 Arabidopsis thaliana 129-155 24285094-3 2014 Cysteine is synthesized during the sulfate assimilation pathway via the incorporation of sulfide to O-acetylserine, catalyzed by O-acetylserine(thiol)lyase (OASTL). Sulfides 89-96 cysteine synthase 26 Arabidopsis thaliana 157-162 24436288-1 2014 Easier with ethyl: Guengerich and co-workers have developed a powerful new approach to the structure elucidation of hydrolytically stable AGT-DNA crosslinks by reductive desulfurization of the thioether linkage between AGT and DNA to convert cysteine DPCs to the corresponding ethyl-DNA adducts, which can be readily characterized by LC-MSn. Sulfides 193-202 angiotensinogen Homo sapiens 138-141 24436288-1 2014 Easier with ethyl: Guengerich and co-workers have developed a powerful new approach to the structure elucidation of hydrolytically stable AGT-DNA crosslinks by reductive desulfurization of the thioether linkage between AGT and DNA to convert cysteine DPCs to the corresponding ethyl-DNA adducts, which can be readily characterized by LC-MSn. Sulfides 193-202 angiotensinogen Homo sapiens 219-222 24436288-1 2014 Easier with ethyl: Guengerich and co-workers have developed a powerful new approach to the structure elucidation of hydrolytically stable AGT-DNA crosslinks by reductive desulfurization of the thioether linkage between AGT and DNA to convert cysteine DPCs to the corresponding ethyl-DNA adducts, which can be readily characterized by LC-MSn. Sulfides 193-202 moesin Homo sapiens 337-340 25076515-2 2014 Although arsenite (As(III)) is generally more mobile and more toxic than arsenate (As(V)), reducing As(V) to As(III) may still be a means for decontamination, because As(III) can be removed from solution by precipitation with sulfide or by adsorption or complexation with other metal sulfides. Sulfides 226-233 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 100-105 24494198-2 2014 Using RFL-6 cells as an NO reporter system we sought to investigate whether sulfide can also modulate nitrosothiol-mediated soluble guanylyl cyclase (sGC) activation following direct chemical interaction. Sulfides 76-83 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 150-153 24494198-3 2014 We find a U-shaped dose response relationship where low sulfide concentrations attenuate sGC stimulation by S-nitrosopenicillamine (SNAP) and cyclic GMP levels are restored at equimolar ratios. Sulfides 56-63 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 89-92 24717654-4 2014 This sensor responded linearly to sulfide in the range of 50 nM to 8 muM, and was capable of detecting sulfide as low as 5.5 nM. Sulfides 103-110 latexin Homo sapiens 69-72 24100226-7 2013 Based on the available evidences we propose the following model: CYSL-1 interacts with EGL-9 and activates HIF-1 that upregulates expression of genes detoxifying sulfide and cyanide, the CYSL-2 acts as a cyanoalanine synthase in the cyanide detoxification pathway and simultaneously produces hydrogen sulfide, while the role of CYSL-3 remains unclear although it exhibits sulfhydrylase activity in vitro. Sulfides 162-169 Cysteine synthase 1 Caenorhabditis elegans 65-71 24145545-0 2014 Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions. Sulfides 124-133 tegument serine/threonine protein kinase Human betaherpesvirus 5 22-26 23863118-6 2013 Bom-BiSpCx was generated by thioether bond between Bombesin to Anti-DTPA antibody. Sulfides 28-37 gastrin releasing peptide Homo sapiens 51-59 23942966-6 2013 Meanwhile, this facile, rapid microwave-assisted strategy is scalable and can be extended to synthesize other oxide/sulfide (MOx/MSy) heterostructures. Sulfides 116-123 monooxygenase DBH like 1 Homo sapiens 125-128 23939954-4 2013 The Ru-CMs showed photocatalytic activity and selectivity in the oxidation of sulfides that were as high as those of the well-known [Ru(bpy)3(PF6)2] complex, because the micelles were swollen in the methanol-sulfide mixture. Sulfides 78-86 sperm associated antigen 17 Homo sapiens 142-145 23939954-4 2013 The Ru-CMs showed photocatalytic activity and selectivity in the oxidation of sulfides that were as high as those of the well-known [Ru(bpy)3(PF6)2] complex, because the micelles were swollen in the methanol-sulfide mixture. Sulfides 78-85 sperm associated antigen 17 Homo sapiens 142-145 24649672-2 2013 Sodium sulfide dissolved in tap water was pumped into the bioreactor as sulfide for biological desulfurization. Sulfides 7-14 nuclear RNA export factor 1 Homo sapiens 28-31 24117256-1 2013 Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR). Sulfides 9-16 cystathionine beta-synthase Homo sapiens 57-84 24117256-1 2013 Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR). Sulfides 9-16 cystathionine gamma-lyase Homo sapiens 94-119 24117256-1 2013 Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR). Sulfides 9-16 cystathionine gamma-lyase Homo sapiens 121-124 24117256-1 2013 Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR). Sulfides 9-16 crystallin zeta Homo sapiens 187-209 23998564-6 2013 The total sulfide concentration was found to be nearly zero in HeLa cells and 4-7 muM in rat colon tissues. Sulfides 10-17 latexin Homo sapiens 82-85 23350603-7 2013 CONCLUSION: The CDO(-/-) mouse clearly demonstrates that H2S/HS(-) production in tissues can exceed the capacity of the animal to oxidize sulfide to sulfate and demonstrates that pancreas and lung are more susceptible to toxicity from endogenous H2S/HS(-)production than are liver and kidney. Sulfides 138-145 cysteine dioxygenase 1, cytosolic Mus musculus 16-19 23505041-2 2013 An 11-residue thioether-cyclized peptide known as G7-18NATE has previously been developed, that inhibits Grb7 via specific interactions with its SH2 domain with micromolar affinity. Sulfides 14-23 growth factor receptor bound protein 7 Homo sapiens 105-109 24001608-2 2013 In Arabidopsis (Arabidopsis thaliana), nine genes encode for O-acetylserine(thiol)lyase (OAS-TL)-like proteins, of which the major isoforms, OAS-TL A, OAS-TL B, and OAS-TL C, catalyze the formation of Cys by combining O-acetylserine and sulfide in the cytosol, the plastids, and the mitochondria, respectively. Sulfides 237-244 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 61-87 24001608-2 2013 In Arabidopsis (Arabidopsis thaliana), nine genes encode for O-acetylserine(thiol)lyase (OAS-TL)-like proteins, of which the major isoforms, OAS-TL A, OAS-TL B, and OAS-TL C, catalyze the formation of Cys by combining O-acetylserine and sulfide in the cytosol, the plastids, and the mitochondria, respectively. Sulfides 237-244 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 89-95 24001608-2 2013 In Arabidopsis (Arabidopsis thaliana), nine genes encode for O-acetylserine(thiol)lyase (OAS-TL)-like proteins, of which the major isoforms, OAS-TL A, OAS-TL B, and OAS-TL C, catalyze the formation of Cys by combining O-acetylserine and sulfide in the cytosol, the plastids, and the mitochondria, respectively. Sulfides 237-244 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 141-147 24001608-2 2013 In Arabidopsis (Arabidopsis thaliana), nine genes encode for O-acetylserine(thiol)lyase (OAS-TL)-like proteins, of which the major isoforms, OAS-TL A, OAS-TL B, and OAS-TL C, catalyze the formation of Cys by combining O-acetylserine and sulfide in the cytosol, the plastids, and the mitochondria, respectively. Sulfides 237-244 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 141-147 24001608-2 2013 In Arabidopsis (Arabidopsis thaliana), nine genes encode for O-acetylserine(thiol)lyase (OAS-TL)-like proteins, of which the major isoforms, OAS-TL A, OAS-TL B, and OAS-TL C, catalyze the formation of Cys by combining O-acetylserine and sulfide in the cytosol, the plastids, and the mitochondria, respectively. Sulfides 237-244 O-acetylserine (thiol) lyase (OAS-TL) Arabidopsis thaliana 141-147 24059525-0 2013 Sulfide inhibition of and metabolism by cytochrome c oxidase. Sulfides 0-7 cytochrome c, somatic Homo sapiens 40-52 24059525-5 2013 Mitochondrial cytochrome c oxidase in an aerobic steady state with ascorbate and cytochrome c is rapidly inhibited by sulfide in a biphasic manner. Sulfides 118-125 cytochrome c, somatic Homo sapiens 14-26 24059525-5 2013 Mitochondrial cytochrome c oxidase in an aerobic steady state with ascorbate and cytochrome c is rapidly inhibited by sulfide in a biphasic manner. Sulfides 118-125 cytochrome c, somatic Homo sapiens 81-93 23615622-3 2013 In contrast, ligand L2 led to the coordination polymer [{Ag2(mu3-L2,-P,P,S)2(MeCN)2}{Ag2(mu2-L2-P,P)2(MeCN)2}(BF4)4]n (2) in which the tethered thioether group connects intermolecularly a Ag2 unit to the diphosphine bridging the other Ag2 unit. Sulfides 144-153 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 57-60 23615622-3 2013 In contrast, ligand L2 led to the coordination polymer [{Ag2(mu3-L2,-P,P,S)2(MeCN)2}{Ag2(mu2-L2-P,P)2(MeCN)2}(BF4)4]n (2) in which the tethered thioether group connects intermolecularly a Ag2 unit to the diphosphine bridging the other Ag2 unit. Sulfides 144-153 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 85-88 23615622-3 2013 In contrast, ligand L2 led to the coordination polymer [{Ag2(mu3-L2,-P,P,S)2(MeCN)2}{Ag2(mu2-L2-P,P)2(MeCN)2}(BF4)4]n (2) in which the tethered thioether group connects intermolecularly a Ag2 unit to the diphosphine bridging the other Ag2 unit. Sulfides 144-153 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 85-88 23615622-3 2013 In contrast, ligand L2 led to the coordination polymer [{Ag2(mu3-L2,-P,P,S)2(MeCN)2}{Ag2(mu2-L2-P,P)2(MeCN)2}(BF4)4]n (2) in which the tethered thioether group connects intermolecularly a Ag2 unit to the diphosphine bridging the other Ag2 unit. Sulfides 144-153 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 85-88 23800285-3 2013 In patients suffering from EE (ethylmalonic encephalopathy), a block in sulfide oxidation at the level of the SDO (sulfur dioxygenase) ETHE1 leads to severe dysfunctions in microcirculation and cellular energy metabolism. Sulfides 72-79 ETHE1 persulfide dioxygenase Homo sapiens 135-140 23747557-7 2013 Below the oxic layer, Fe(III) and sulfate reduction peaks developed concomitantly and the resulting Fe(II) and S(II) were removed as sulfides and probably as S linked to organic matter. Sulfides 133-141 transcription elongation factor A1 Homo sapiens 111-116 23498919-4 2013 Through the combination of single-peptoid mimics and thio-ether bridged cyclization, we successfully demonstrated for the first time two cyclic peptomers, PL-116 and PL-120, dramatically improved the binding affinity without losing mono-specificity against Plk1 PBD in comparison with the linear parental peptide, PLHSpT. Sulfides 53-63 polo like kinase 1 Homo sapiens 257-261 23796308-4 2013 We have previously reported similar structural mobility for the C-terminal domain of human NFU, a protein that has been implicated in the production of sulfide for cluster synthesis, while homologous proteins have also been suggested to serve as Fe-S cluster carriers. Sulfides 152-159 NFU1 iron-sulfur cluster scaffold Homo sapiens 91-94 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 55-62 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 5-11 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 55-62 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 16-22 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 55-62 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 5-9 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 68-75 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 5-11 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 68-75 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 16-22 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 68-75 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 5-9 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 68-75 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 5-11 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 68-75 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 16-22 23479079-11 2013 Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes. Sulfides 68-75 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 5-9 23479079-7 2013 Sulfide enhanced the cleavage of caspase-3 and poly (ADP-ribose) polymerase and induced early cellular apoptosis. Sulfides 0-7 caspase 3 Homo sapiens 33-75 23334151-0 2013 Direct detection of sulfide ions [S2-] in aqueous media based on fluorescence quenching of functionalized CdS QDs at trace levels: analytical applications to environmental analysis. Sulfides 20-27 CDP-diacylglycerol synthase 1 Homo sapiens 106-109 23432160-5 2013 We previously reported a spatial scanning approach of a 10-membered thioether-heterocycle ring incorporated into a chimeric peptide template that identified a lead nM MC4R ligand. Sulfides 68-77 melanocortin 4 receptor Mus musculus 167-171 23428891-2 2013 In mammals, two cytosolic enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), have been shown to be responsible for the endogenous production of sulfide. Sulfides 173-180 cystathionine beta-synthase Homo sapiens 35-62 23428891-2 2013 In mammals, two cytosolic enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), have been shown to be responsible for the endogenous production of sulfide. Sulfides 173-180 cystathionine beta-synthase Homo sapiens 64-67 23428891-2 2013 In mammals, two cytosolic enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), have been shown to be responsible for the endogenous production of sulfide. Sulfides 173-180 cystathionine gamma-lyase Homo sapiens 73-98 23428891-2 2013 In mammals, two cytosolic enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), have been shown to be responsible for the endogenous production of sulfide. Sulfides 173-180 cystathionine gamma-lyase Homo sapiens 100-103 23402224-1 2013 BACKGROUND: Trastuzumab emtansine (T-DM1), a novel drug developed for the treatment of HER2-positive breast cancer, is a human epidermal growth factor receptor (HER2) targeted antibody drug conjugate, composed of trastuzumab, a stable thioether linker, and the potent cytotoxic agent DM1 (derivative of maytansine). Sulfides 235-244 immunoglobulin heavy diversity 1-7 Homo sapiens 37-40 23402224-1 2013 BACKGROUND: Trastuzumab emtansine (T-DM1), a novel drug developed for the treatment of HER2-positive breast cancer, is a human epidermal growth factor receptor (HER2) targeted antibody drug conjugate, composed of trastuzumab, a stable thioether linker, and the potent cytotoxic agent DM1 (derivative of maytansine). Sulfides 235-244 epidermal growth factor receptor Homo sapiens 127-159 23334151-1 2013 A novel, simple but highly selective fluorescent probe is developed for the direct detection of sulfide ions [S(2-)] based on the fluorescence quenching of the functionalized CdS QDs in aqueous solution at trace levels and successfully applied for quantitation of S(2-) from water samples in a complex matrix exclusive of pretreatment by standard addition method. Sulfides 96-103 CDP-diacylglycerol synthase 1 Homo sapiens 175-178 23221833-1 2013 Plant sulfite reductase (SiR; Enzyme Commission 1.8.7.1) catalyzes the reduction of sulfite to sulfide in the reductive sulfate assimilation pathway. Sulfides 95-102 sulfite reductase Arabidopsis thaliana 6-23 23280874-3 2013 A new thioether-ligation method for the synthesis of two- and three-component vaccines that contain MUC1 glycopeptides as the B-cell epitopes, a T-cell epitope peptide, and the Pam(3)CSK(4) lipopeptide is described. Sulfides 6-15 mucin 1, transmembrane Mus musculus 100-104 23220955-3 2013 Distinct compositional differences between bacteria that utilize their SoxB enzyme in the Paracoccus sulfide oxidation pathway (e.g., Bradyrhizobium, Paracoccus, and Rhodovulum) and bacteria that utilize their SoxB enzyme in the branched pathway (e.g., Chlorobium, Thiothrix, Thiobacillus, Halothiobacillus, and Thiomonas) were identified. Sulfides 101-108 SRY-box transcription factor 3 Homo sapiens 71-75 23164996-7 2013 The MAbF12 binding site in the p55(gag), p36 and p22 proteins was found to be a linear epitope with cross-linked sulphide bonds. Sulfides 113-121 H3 histone pseudogene 44 Homo sapiens 31-34 23164996-7 2013 The MAbF12 binding site in the p55(gag), p36 and p22 proteins was found to be a linear epitope with cross-linked sulphide bonds. Sulfides 113-121 gag protein Caprine arthritis encephalitis virus 35-38 23164996-7 2013 The MAbF12 binding site in the p55(gag), p36 and p22 proteins was found to be a linear epitope with cross-linked sulphide bonds. Sulfides 113-121 annexin A2 Homo sapiens 41-44 23164996-7 2013 The MAbF12 binding site in the p55(gag), p36 and p22 proteins was found to be a linear epitope with cross-linked sulphide bonds. Sulfides 113-121 calcineurin like EF-hand protein 1 Homo sapiens 49-52 23193175-3 2013 Here we report that NSP5 is a unique viral metalloprotein that coordinates a [2Fe-2S] iron-sulfur cluster as demonstrated by the metal and labile sulfide contents, UV-visible light absorption, and electron paramagnetic resonance. Sulfides 146-153 sperm antigen with calponin homology and coiled-coil domains 1 Homo sapiens 20-24 23221833-1 2013 Plant sulfite reductase (SiR; Enzyme Commission 1.8.7.1) catalyzes the reduction of sulfite to sulfide in the reductive sulfate assimilation pathway. Sulfides 95-102 sulfite reductase Arabidopsis thaliana 25-28 23276279-3 2013 In our continued effort to design a proteolytically stable ligand with specific receptor binding, we have engineered peptides by cyclizing gamma-MSH using a thioether bridge. Sulfides 157-166 proopiomelanocortin Homo sapiens 139-148 23276279-4 2013 A number of novel cyclic truncated gamma-MSH analogues were designed and synthesized, in which a thioether bridge was incorporated between a cysteine side chain and an N-terminal bromoacyl group. Sulfides 97-106 proopiomelanocortin Homo sapiens 35-44 23591875-3 2013 This strategy is based on Ag2S formation-induced spectral shifts of the nanoprobes, which is not only highly selective towards sulphide but also shows a linear logarithmic dependence on sulphide concentrations from 0.01 nM to 10 muM. Sulfides 127-135 angiotensin II receptor type 1 Homo sapiens 26-30 23282011-5 2013 By mutational analysis of both cluster-binding sites, we were able to postulate a mechanism for thioether generation which is in agreement with that of AlbA. Sulfides 96-105 subtilosin A thioether formation enzyme Bacillus subtilis subsp. subtilis str. 168 152-156 23302031-4 2013 Studies reveal that L(1)-Cu complex is selectively and fully reversible in presence of sulfide anions. Sulfides 87-94 immunoglobulin kappa variable 1-16 Homo sapiens 20-24 23199730-4 2013 Biological responses to increasing sulfide were variable; however a significant biological threshold was evident at 1500 muM. Sulfides 35-42 latexin Homo sapiens 121-124 22921659-4 2013 Fitting these data to a kinetic model lead to an estimated microbial sulfide production rate in the range of 19-28 muM d(-1) at steady state. Sulfides 69-76 latexin Homo sapiens 115-118 22921659-6 2013 Before the establishment of the steady state conditions, steep fluctuations in sulfide concentration (between 1mM and several muM) were observed in the wood interior. Sulfides 79-86 latexin Homo sapiens 126-129 23517428-1 2013 We report the in vitro selection of thioether-macrocyclized peptides against vascular endothelial growth factor receptor 2 (VEGFR2) from multiple, highly diverse peptide libraries constructed utilizing genetic code reprogramming. Sulfides 36-45 kinase insert domain receptor Homo sapiens 77-122 23517428-1 2013 We report the in vitro selection of thioether-macrocyclized peptides against vascular endothelial growth factor receptor 2 (VEGFR2) from multiple, highly diverse peptide libraries constructed utilizing genetic code reprogramming. Sulfides 36-45 kinase insert domain receptor Homo sapiens 124-130 23591875-3 2013 This strategy is based on Ag2S formation-induced spectral shifts of the nanoprobes, which is not only highly selective towards sulphide but also shows a linear logarithmic dependence on sulphide concentrations from 0.01 nM to 10 muM. Sulfides 127-135 latexin Homo sapiens 229-232 23591875-3 2013 This strategy is based on Ag2S formation-induced spectral shifts of the nanoprobes, which is not only highly selective towards sulphide but also shows a linear logarithmic dependence on sulphide concentrations from 0.01 nM to 10 muM. Sulfides 186-194 angiotensin II receptor type 1 Homo sapiens 26-30 23591875-3 2013 This strategy is based on Ag2S formation-induced spectral shifts of the nanoprobes, which is not only highly selective towards sulphide but also shows a linear logarithmic dependence on sulphide concentrations from 0.01 nM to 10 muM. Sulfides 186-194 latexin Homo sapiens 229-232 23082897-8 2012 The results suggest that accounting for the double thioether link between heme c and peptide, and the use of the labile heme fragment as a reporter ion, can improve database searching results. Sulfides 51-60 HEME Bos taurus 74-78 22947039-5 2012 However, Hcp2(+) GEI(-) or Hcp2(-) GEI(-) cells were unable to use lactate, causing sulfide to be used as electron donor for nitrite reduction at a sixfold lower rate. Sulfides 84-91 CYCS pseudogene 52 Homo sapiens 9-13 22511607-3 2012 The hydrogen sulfide released also inhibits the cytochrome c oxidase and needs to be detoxified by the O-acetylserine(thiol)lyase mitochondrial isoform, OAS-C, which catalyzes the incorporation of sulfide to O-acetylserine to produce cysteine, thus generating a cyclic pathway in the mitochondria. Sulfides 13-20 O-acetylserine (thiol) lyase Arabidopsis thaliana 153-158 22511607-6 2012 The mitochondria compromise their capacity to properly detoxify cyanide and the resulting sulfide because the latter cannot re-assimilate into cysteine in the oas-c null mutant. Sulfides 90-97 O-acetylserine (thiol) lyase Arabidopsis thaliana 159-164 22511607-8 2012 Our results allow us to suggest that the significance of OAS-C is related to its role in the proper sulfide and cyanide detoxification in mitochondria. Sulfides 100-107 O-acetylserine (thiol) lyase Arabidopsis thaliana 57-62 23144183-2 2012 Detailed characterization of the T-DNA insertion mutants des1-1 and des1-2 has provided insight into the role of sulfide metabolically generated in the cytosol as a signaling molecule. Sulfides 113-120 L-cysteine desulfhydrase 1 Arabidopsis thaliana 57-61 23144183-2 2012 Detailed characterization of the T-DNA insertion mutants des1-1 and des1-2 has provided insight into the role of sulfide metabolically generated in the cytosol as a signaling molecule. Sulfides 113-120 L-cysteine desulfhydrase 1 Arabidopsis thaliana 68-72 21538942-3 2012 The second method depends on hydrolysis of CFD using 0.5 M NaOH at 100 C and subsequent reaction of the formed sulfide ions with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form a yellow-coloured chromogen measured at 390 nm. Sulfides 112-119 OXA1L mitochondrial inner membrane protein Homo sapiens 154-159 22434643-16 2012 CONCLUSIONS: We found an impaired detoxification mechanism of sulfide at TST protein and RNA level in UC. Sulfides 62-69 thiosulfate sulfurtransferase Homo sapiens 73-76 23018275-6 2012 We found that SufB(2)C(2) was most proficient as a scaffold for de novo assembly of holo-Fdx using sulfide and iron as freely available building blocks while SufA was best at direct transfer of a pre-formed FeS cluster to Fdx. Sulfides 99-106 ferredoxin 1 Homo sapiens 89-92 22947039-5 2012 However, Hcp2(+) GEI(-) or Hcp2(-) GEI(-) cells were unable to use lactate, causing sulfide to be used as electron donor for nitrite reduction at a sixfold lower rate. Sulfides 84-91 CYCS pseudogene 52 Homo sapiens 27-31 22777116-1 2012 Previous studies suggest that sulfide-induced inhibition of cytochrome c oxidase (cCox) and, consequently, the metabolic and toxic effects of sulfide are less pronounced at low body temperature. Sulfides 30-37 cytochrome c oxidase subunit 5A Mus musculus 60-80 22326804-3 2012 The plasticity in the Cu(II) coordination sphere, and the diffuseness of the lone pair electrons of a thioether sulfur, allow Cu(II)-S(thioether) bond distances to vary from 2.4 to 3.2 A, as shown by an in-depth analysis of protein structures (Protein Structure Database, PDB) and molecular structures of copper coordination compounds (Cambridge Structural Database, CSD). Sulfides 102-111 PDB1 Homo sapiens 272-275 22777116-1 2012 Previous studies suggest that sulfide-induced inhibition of cytochrome c oxidase (cCox) and, consequently, the metabolic and toxic effects of sulfide are less pronounced at low body temperature. Sulfides 30-37 cytochrome c oxidase subunit 5A Mus musculus 82-86 22777116-1 2012 Previous studies suggest that sulfide-induced inhibition of cytochrome c oxidase (cCox) and, consequently, the metabolic and toxic effects of sulfide are less pronounced at low body temperature. Sulfides 142-149 cytochrome c oxidase subunit 5A Mus musculus 82-86 22777116-6 2012 This effect was even greater at 25 C than at 37 C. Furthermore, only the AMJ2-C11 cells remained viable after sulfide exposure for 24 h. In contrast, only in the RAW 264.7 cells that an increase in cCox excess capacity was found at low temperatures. Sulfides 110-117 cytochrome c oxidase subunit 5A Mus musculus 198-202 22903887-2 2012 ETHE1, encoding sulfur dioxygenase (SDO), which takes part in the mitochondrial pathway that converts sulfide into harmless sulfate, is mutated in EE. Sulfides 102-109 ethylmalonic encephalopathy 1 Mus musculus 0-5 23000765-8 2012 RESULTS: Compared with the model group, the levels of ALT, AST, HA, LN, and PC III in the sulfide group were significantly reduced (P<0.01 or P<0.05), ALB content was increased (P<0.05) in the serum, TGF-beta1 expression was obviously reduced, and the degree of liver fibrosis was improved (P<0.05). Sulfides 90-97 albumin Rattus norvegicus 157-160 22786886-7 2012 Therefore, ETHE1 appears to play an essential role in regulating sulfide levels in seeds. Sulfides 65-72 glyoxalase II 3 Arabidopsis thaliana 11-16 23000765-8 2012 RESULTS: Compared with the model group, the levels of ALT, AST, HA, LN, and PC III in the sulfide group were significantly reduced (P<0.01 or P<0.05), ALB content was increased (P<0.05) in the serum, TGF-beta1 expression was obviously reduced, and the degree of liver fibrosis was improved (P<0.05). Sulfides 90-97 transforming growth factor, beta 1 Rattus norvegicus 209-218 22904573-2 2012 Whereas [Pt(dien)Cl]Cl and [Pt(dien)(D(2)O)](2+) have been known to react faster with thioether residues such as N-AcMet than with 5"-GMP, we found that [Pt(Me(4)en)(D(2)O)(2)](2+) appeared to react faster with 5"-GMP. Sulfides 86-95 5'-nucleotidase, cytosolic II Homo sapiens 214-217 22852582-0 2012 Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. Sulfides 6-13 crystallin zeta Homo sapiens 14-36 22318304-3 2012 At the progression front of BBD lesions, high sulphide levels up to 4977 muM were measured in darkness along with lower than ambient levels of pH (7.43+-0.20). Sulfides 46-54 latexin Homo sapiens 73-76 22685081-1 2012 Sulfite reductase (SiR; EC 1.8.7.1), an essential enzyme in the sulfate reduction pathway, catalyzes the reduction of sulfite to sulfide, as an intermediate for cysteine biosynthesis. Sulfides 129-136 sulfite reductase Arabidopsis thaliana 0-17 22685081-1 2012 Sulfite reductase (SiR; EC 1.8.7.1), an essential enzyme in the sulfate reduction pathway, catalyzes the reduction of sulfite to sulfide, as an intermediate for cysteine biosynthesis. Sulfides 129-136 sulfite reductase Arabidopsis thaliana 19-22 22685081-2 2012 The commonly used kinetic assay for the detection of in vitro SiR activity in plants is based on a coupled reaction, in which the sulfide produced is converted to cysteine through the presence, in the assay medium, of O-acetylserine sulfhydralase (EC 2.5.1.47) and its substrate, O-acetylserine. Sulfides 130-137 sulfite reductase Arabidopsis thaliana 62-65 22616571-1 2012 The complexation of a preorganized thioether-functionalized bis(pyrazolyl)methane ligand (L) with silver precursors produces supramolecular structures organized at two hierarchical levels: [AgL](6)(X)(6) metal-organic cyclic hexamers and their organization in 3D architectures. Sulfides 35-44 amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase Homo sapiens 190-193 22748487-5 2012 Total plasma sulfide concentrations in these patients was lower compared with a control group (5.32 [2.22, 8.00] muM vs. 8.5 [6.00, 14.00] muM; P = .05). Sulfides 13-20 latexin Homo sapiens 113-116 22748487-5 2012 Total plasma sulfide concentrations in these patients was lower compared with a control group (5.32 [2.22, 8.00] muM vs. 8.5 [6.00, 14.00] muM; P = .05). Sulfides 13-20 latexin Homo sapiens 139-142 22748487-6 2012 Total plasma sulfide decreased significantly across the New York Heart Association (NYHA) functional classes (II, 5.84 [4.33, 8.00] muM vs. III, 4.67 [4.00, 7.17] muM vs. IV, 2.67 [2.22, 4.31] muM; P = .001). Sulfides 13-20 latexin Homo sapiens 132-135 22748487-6 2012 Total plasma sulfide decreased significantly across the New York Heart Association (NYHA) functional classes (II, 5.84 [4.33, 8.00] muM vs. III, 4.67 [4.00, 7.17] muM vs. IV, 2.67 [2.22, 4.31] muM; P = .001). Sulfides 13-20 latexin Homo sapiens 163-166 22748487-6 2012 Total plasma sulfide decreased significantly across the New York Heart Association (NYHA) functional classes (II, 5.84 [4.33, 8.00] muM vs. III, 4.67 [4.00, 7.17] muM vs. IV, 2.67 [2.22, 4.31] muM; P = .001). Sulfides 13-20 latexin Homo sapiens 163-166 22748487-7 2012 The total plasma sulfide negatively correlated with pro-BNP (R(2) cubic, 0.692; P = .001) and pulmonary artery systolic pressure (R(2) cubic, 0.569; P = .001). Sulfides 17-24 natriuretic peptide B Homo sapiens 56-59 22748487-10 2012 CONCLUSION: Total plasma sulfide is negatively related to severity of congestive heart failure: it is lowest in NYHA Class IV and in patients with high pro-BNP and high pulmonary artery pressure. Sulfides 25-32 natriuretic peptide B Homo sapiens 156-159 22531851-3 2012 To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG. Sulfides 175-184 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 37-40 22531851-3 2012 To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG. Sulfides 175-184 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 90-93 22531851-3 2012 To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG. Sulfides 175-184 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 90-93 22531851-3 2012 To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG. Sulfides 175-184 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 90-93 22369066-4 2012 The capacity of HT-29 Glc(-/+) cells to oxidize lower concentration of sulfide was associated with the expression of transcripts corresponding to the enzymes of the sulfide oxidizing unit (SOU), that is, sulfide quinone reductase (SQR), dioxygenase ethylmalonic encephalopathy, and thiosulfate sulfur transferase (TST). Sulfides 71-78 thiosulfate sulfurtransferase Homo sapiens 282-312 22369066-4 2012 The capacity of HT-29 Glc(-/+) cells to oxidize lower concentration of sulfide was associated with the expression of transcripts corresponding to the enzymes of the sulfide oxidizing unit (SOU), that is, sulfide quinone reductase (SQR), dioxygenase ethylmalonic encephalopathy, and thiosulfate sulfur transferase (TST). Sulfides 71-78 thiosulfate sulfurtransferase Homo sapiens 314-317 22271209-1 2012 PURPOSE: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate comprising trastuzumab and DM1, a microtubule polymerization inhibitor, covalently bound via a stable thioether linker. Sulfides 171-180 DM1 protein kinase Homo sapiens 34-37 22513652-2 2012 This multifunctional use of the sulfide source has been achieved through a fine tuning of ((Cu2+)(a)(Zn2+)(b)(Sn4+)(c)(Tu)(d)(OH-)(e))(t+), Tu = thiourea) oligomers, leading after temperature polycondensation and S2- exchange to highly concentrated (c > 100 g l-1), stable, ethanolic CZTS dispersions. Sulfides 32-39 L1 cell adhesion molecule Homo sapiens 263-266 22465636-2 2012 The introduction of A ring pyrazole modification to the hydrocortisone C-21 heteroaryl thioethers generated compounds with excellent transrepression potency (IL-8 inhibition) compared to their hydrocortisone analogs. Sulfides 87-97 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 22271209-1 2012 PURPOSE: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate comprising trastuzumab and DM1, a microtubule polymerization inhibitor, covalently bound via a stable thioether linker. Sulfides 171-180 DM1 protein kinase Homo sapiens 96-99 22020834-4 2012 By studying a suitable mouse model, we found that loss of ETHE1 leads to accumulation of sulphide, which is a poison for COX and other enzymatic activities thus accounting for the main features of EE. Sulfides 89-97 ethylmalonic encephalopathy 1 Mus musculus 58-63 22227701-0 2012 A fluorescence turn-on sensor for Hg2+ with a simple receptor available in sulphide-rich environments. Sulfides 75-83 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 34-37 22408268-1 2012 Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate consisting of the anti-HER2 antibody trastuzumab linked via a nonreducible thioether linker to the maytansinoid antitubulin agent DM1. Sulfides 135-144 DM1 protein kinase Homo sapiens 25-28 22328155-5 2012 Nonadjacent thiol and thioether groups in MTMT suggest involvement of a chelated metal complex in MOR244-3 activation. Sulfides 22-31 olfactory receptor family 4 subfamily E member 2 Mus musculus 98-106 21805125-0 2012 Molecular modeling of cytochrome b5 with a single cytochrome c-like thioether linkage. Sulfides 68-77 cytochrome b5 type A Bos taurus 22-35 21805125-0 2012 Molecular modeling of cytochrome b5 with a single cytochrome c-like thioether linkage. Sulfides 68-77 LOC104968582 Bos taurus 50-62 21805125-1 2012 Bovine liver cytochrome b (5) (cyt b (5)), with heme bound noncovalently, has been converted into a cyt c-like protein (cyt b (5) N57C) by constructing a thioether linkage between the heme and the engineered cysteine residue. Sulfides 154-163 cytochrome b Bos taurus 13-25 21805125-1 2012 Bovine liver cytochrome b (5) (cyt b (5)), with heme bound noncovalently, has been converted into a cyt c-like protein (cyt b (5) N57C) by constructing a thioether linkage between the heme and the engineered cysteine residue. Sulfides 154-163 cytochrome b Bos taurus 31-36 21805125-1 2012 Bovine liver cytochrome b (5) (cyt b (5)), with heme bound noncovalently, has been converted into a cyt c-like protein (cyt b (5) N57C) by constructing a thioether linkage between the heme and the engineered cysteine residue. Sulfides 154-163 cytochrome b Bos taurus 120-125 22292618-4 2012 The system is composed of superoxide dismutase (SOD) conjugated to oxidation-sensitive amphiphilic polysulfide/PEG block copolymers; the conjugate combines the SOD reactivity toward superoxide with that of hydrophobic thioethers toward hydrogen peroxide. Sulfides 218-228 superoxide dismutase 1 Homo sapiens 26-46 22292618-4 2012 The system is composed of superoxide dismutase (SOD) conjugated to oxidation-sensitive amphiphilic polysulfide/PEG block copolymers; the conjugate combines the SOD reactivity toward superoxide with that of hydrophobic thioethers toward hydrogen peroxide. Sulfides 218-228 superoxide dismutase 1 Homo sapiens 48-51 22212659-4 2012 Most of the cbbM phylotypes recovered from the liquid samples were related to those of the SUP05 group that belongs to the Gammaproteobacteria and includes putative sulfide-oxidizing chemolithoautotrophs. Sulfides 165-172 opsin 1, medium wave sensitive Homo sapiens 12-16 22679365-2 2012 METHODS: Liposomes consisting of phosphatidylcholine (POPC) and a maleimide-functionalized lipid were incubated with chitosan-TGA, leading to the formation of a thioether bond between free SH-groups of the polymer and maleimide groups of the liposome. Sulfides 161-170 T-box transcription factor 1 Homo sapiens 126-129 22149108-2 2012 A sulfide-footed deep, self-folding cavitand has been synthesized, and its attachment to a cleaned gold surface studied by electrochemical and SPR methods. Sulfides 2-9 sepiapterin reductase Homo sapiens 143-146 22221135-0 2012 Formation of a uranium trithiocarbonate complex via the nucleophilic addition of a sulfide-bridged uranium complex to CS2. Sulfides 83-90 chorionic somatomammotropin hormone 2 Homo sapiens 118-121 22169147-8 2012 The reactivity of Pd/Fe RGM decreased severely at 10mM sulfide concentration and with long-term aging of RGM in the atmosphere for three years. Sulfides 55-62 repulsive guidance molecule BMP co-receptor a Homo sapiens 24-27 22754607-1 2012 We report the design and synthesis of novel FTPA-triazole compounds as potent inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), through a focus on thioether and isoprenoid mimetics. Sulfides 164-173 isoprenylcysteine carboxyl methyltransferase Homo sapiens 138-142 23136534-5 2012 The reaction of the anomeric allyl group with 1,3-propanedithiol under radical conditions afforded the thioether-bridged spacer glycosides, which were efficiently coupled to maleimide-activated bovine serum albumin. Sulfides 103-112 albumin Homo sapiens 201-214 22121478-0 2012 The effect of the thioether-bridged, stabilized Angiotensin-(1-7) analogue cyclic ang-(1-7) on cardiac remodeling and endothelial function in rats with myocardial infarction. Sulfides 18-27 angiogenin Rattus norvegicus 82-90 22121478-3 2012 We investigated effects of a stabilized, thioether-bridged analogue of Ang-(1-7) called cyclic Ang-(1-7) in rat model of myocardial infarction. Sulfides 41-50 angiogenin Rattus norvegicus 71-79 22121478-3 2012 We investigated effects of a stabilized, thioether-bridged analogue of Ang-(1-7) called cyclic Ang-(1-7) in rat model of myocardial infarction. Sulfides 41-50 angiogenin Rattus norvegicus 95-103 22517692-5 2012 SLN marking was performed with blue dye (Patentblau V) and radiotracer (antimony sulfide marked with Tc99m). Sulfides 81-88 sarcolipin Homo sapiens 0-3 21924895-5 2011 Sulfide oxidation was disrupted in the final step, indicating that COD and sulfide oxidation occurred prior to methane oxidation. Sulfides 0-7 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 67-70 22007676-3 2011 The spacing between one of the palmitoyl ester carbonyl and the thioether is crucial to allow for an important H-bond, which observed in the crystal structure of the lipopeptide:TLR2 complex; consequently, activity is lost in homologated compounds. Sulfides 64-73 toll like receptor 2 Homo sapiens 178-182 21857260-9 2011 While histologic lung injury was variable, both sulfide and hypothermia attenuated the trauma-related increase in heme oxygenase-1 expression and activated caspase-3 staining, which coincided with increased Bad phosphorylation and Bcl-Xl expression. Sulfides 48-55 heme oxygenase 1 Mus musculus 114-130 21857260-9 2011 While histologic lung injury was variable, both sulfide and hypothermia attenuated the trauma-related increase in heme oxygenase-1 expression and activated caspase-3 staining, which coincided with increased Bad phosphorylation and Bcl-Xl expression. Sulfides 48-55 caspase 3 Mus musculus 156-165 21857260-9 2011 While histologic lung injury was variable, both sulfide and hypothermia attenuated the trauma-related increase in heme oxygenase-1 expression and activated caspase-3 staining, which coincided with increased Bad phosphorylation and Bcl-Xl expression. Sulfides 48-55 BCL2-like 1 Mus musculus 231-237 21857260-10 2011 Sulfide and hypothermia also attenuated the trauma-induced cystathionine-beta synthase and cystathionine-gamma lyase expression. Sulfides 0-7 cystathionine beta-synthase Mus musculus 59-86 21857260-10 2011 Sulfide and hypothermia also attenuated the trauma-induced cystathionine-beta synthase and cystathionine-gamma lyase expression. Sulfides 0-7 cystathionase (cystathionine gamma-lyase) Mus musculus 91-116 21840852-5 2011 The H2S-oxidation pathway requires two distinct enzymes important for the oxidation of H2S: the sulfide:quinone reductase sqrd-1 and the dioxygenase ethe-1. Sulfides 96-103 Pyr_redox_2 domain-containing protein Caenorhabditis elegans 122-128 21534614-0 2011 Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors. Sulfides 104-113 nitric oxide synthase 1 Homo sapiens 40-70 21802427-3 2011 The G7-18NATE peptide (sequence: WFEGYDNTFPC cyclized via a thioether bond) is a nonphosphorylated peptide that was developed for the specific inhibition of Grb7 by blocking its SH2 domain. Sulfides 60-69 growth factor receptor bound protein 7 Mus musculus 157-161 21855358-1 2011 LuxS (S-ribosylhomocysteinase) catalyzes the cleavage of the thioether linkage of S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor to a small signaling molecule that mediates interspecies bacterial communication called autoinducer 2 (AI-2). Sulfides 61-70 Lutheran suppressor, X-linked Homo sapiens 0-4 21693435-0 2011 cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma. Sulfides 77-86 calcium and integrin binding 1 Rattus norvegicus 44-52 21693435-0 2011 cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma. Sulfides 77-86 cyclin D1 Rattus norvegicus 53-62 20812865-2 2011 The main consequence of the absence of Ethe1-SDO is the accumulation of sulfide (H(2)S) in critical tissues, including colonic mucosa, liver, muscle, and brain. Sulfides 72-79 ETHE1 persulfide dioxygenase Homo sapiens 39-44 21446951-1 2011 The large sulfur bacteria, Beggiatoa spp., live on the oxidation of sulfide with oxygen or nitrate, but avoid high concentrations of both sulfide and oxygen. Sulfides 68-75 histocompatibility minor 13 Homo sapiens 37-40 21446951-1 2011 The large sulfur bacteria, Beggiatoa spp., live on the oxidation of sulfide with oxygen or nitrate, but avoid high concentrations of both sulfide and oxygen. Sulfides 138-145 histocompatibility minor 13 Homo sapiens 37-40 21782433-3 2011 Modifications of both the prenyl group and thioether of N-acetyl-S-farnesyl-L-cysteine (AFC), a substrate for human Icmt (hIcmt), have resulted in low micromolar inhibitors of Icmt and have given insights into the nature of the prenyl binding site of hIcmt. Sulfides 43-52 isoprenylcysteine carboxyl methyltransferase Homo sapiens 116-120 21770469-6 2011 Focused-ion-beam analysis of surface films reveals an irregular coarse-grained sulfide phase that allows deep (>1 mum) conversion of silver surfaces without passivation. Sulfides 79-86 latexin Homo sapiens 117-120 21786826-5 2011 By taking advantage of this fact, we can detect a concentration of 3 muM for sulfide and 0.4 muM for cysteine with the naked eye or 0.3 muM (10 ppb) for sulfide and 50 nM (6 ppb) for cysteine aided by a UV/vis spectrometer. Sulfides 77-84 latexin Homo sapiens 69-72 21591611-4 2011 Interestingly, the pyrimidine ring including the thioether of 1 could be replaced by a simple benzyl or a benzylidene moiety yielding a novel series of bioactive 2-benzylidene- and 2-benzylhexanoic acids exemplified by 2-(2,3-diphenethoxybenzylidene)hexanoic acid, 29 (IC(50) 5-LO = 0.8 muM; mPGES-1 = 1.1 muM). Sulfides 49-58 latexin Homo sapiens 287-290 21591611-4 2011 Interestingly, the pyrimidine ring including the thioether of 1 could be replaced by a simple benzyl or a benzylidene moiety yielding a novel series of bioactive 2-benzylidene- and 2-benzylhexanoic acids exemplified by 2-(2,3-diphenethoxybenzylidene)hexanoic acid, 29 (IC(50) 5-LO = 0.8 muM; mPGES-1 = 1.1 muM). Sulfides 49-58 prostaglandin E synthase Mus musculus 292-299 21591611-4 2011 Interestingly, the pyrimidine ring including the thioether of 1 could be replaced by a simple benzyl or a benzylidene moiety yielding a novel series of bioactive 2-benzylidene- and 2-benzylhexanoic acids exemplified by 2-(2,3-diphenethoxybenzylidene)hexanoic acid, 29 (IC(50) 5-LO = 0.8 muM; mPGES-1 = 1.1 muM). Sulfides 49-58 latexin Homo sapiens 306-309 21534614-10 2011 We, therefore, have characterized some of these neuronal nitric oxide synthase (nNOS)-thioether inhibitor complexes in both crystal and solution using EPR and UV-visible absorption spectrometry as a function of temperature and the heme iron redox state. Sulfides 86-95 nitric oxide synthase 1 Homo sapiens 48-78 21534614-10 2011 We, therefore, have characterized some of these neuronal nitric oxide synthase (nNOS)-thioether inhibitor complexes in both crystal and solution using EPR and UV-visible absorption spectrometry as a function of temperature and the heme iron redox state. Sulfides 86-95 nitric oxide synthase 1 Homo sapiens 80-84 21488133-4 2011 Using radiolabeled NaB((3) H)H(4) and Raney nickel as well as sulfhydryl assay (Ellman"s reagent), we confirmed that CDA could conjugate with cysteine through a thioether linkage. Sulfides 161-170 cytidine deaminase Homo sapiens 117-120 21472183-1 2011 Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)(3)-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities. Sulfides 195-203 POU class 5 homeobox 1 Homo sapiens 71-80 21410200-1 2011 Deficiency of the sulfide metabolizing protein ETHE1 is the cause of ethylmalonic encephalopathy (EE), an inherited and severe metabolic disorder. Sulfides 18-25 ETHE1 persulfide dioxygenase Homo sapiens 47-52 21410200-5 2011 Sulfide:quinone oxidoreductase (SQRDL), which takes part in the same sulfide pathway as ETHE1, was also underrepresented in EE patients. Sulfides 69-76 crystallin zeta Homo sapiens 8-30 21410200-5 2011 Sulfide:quinone oxidoreductase (SQRDL), which takes part in the same sulfide pathway as ETHE1, was also underrepresented in EE patients. Sulfides 69-76 sulfide quinone oxidoreductase Homo sapiens 32-37 22332041-6 2011 Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec). Sulfides 15-22 selenophosphate synthetase 2 Mus musculus 73-77 22332041-6 2011 Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec). Sulfides 15-22 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 147-150 22332041-6 2011 Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec). Sulfides 15-22 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Mus musculus 171-175 22332041-6 2011 Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec). Sulfides 15-22 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 171-174 21392199-5 2011 Cell-free mat extract contained activities of enzymes involved in sulfate reduction to sulfide: ATP sulfurylase (adenylyl : sulfate transferase; Sat), APS reductase (Apr) and dissimilatory sulfite reductase (Dsr). Sulfides 87-94 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 145-148 20528888-2 2011 It is caused by a defect in the ETHE1 gene product, which was recently shown to be part of a metabolic pathway devoted to sulphide detoxification. Sulfides 122-130 ETHE1 persulfide dioxygenase Homo sapiens 32-37 21499539-5 2011 This review summarizes some key structural and functional properties of three central proteins dedicated to the Fe-S cluster assembly process: namely, the sulfide donor (cysteine desulfurase); iron donor (frataxin), and the iron-sulfur cluster scaffold protein (IscU/ISU). Sulfides 155-162 iron-sulfur cluster assembly enzyme Homo sapiens 262-266 21488133-6 2011 The adducts formed between beta-apo-8-carotenal (BA8C) and N-acetylcysteine and BA8C and N-acetyllysine were confirmed by HPLC and ESI-MS. Our results suggest that CDA could alter protein function by post-translational interaction with cysteine and lysine by thioether linkage and by schiff"s based bonds, respectively. Sulfides 259-268 cytidine deaminase Homo sapiens 164-167 20661185-7 2011 Sulfide also lowered the blood IL-6, IL-1beta, and nitrite + nitrate concentrations, which coincided with reduced kidney oxidative DNA base damage and iNOS expression, and attenuated glomerular histological injury as assessed by the incidence of glomerular tubularization. Sulfides 0-7 interleukin 6 Homo sapiens 31-35 21288051-2 2011 When compound 1 was incubated with NADPH-supplemented human liver microsomes in the presence of glutathione, two thioether conjugates M4-1 and M5-1 were observed. Sulfides 113-122 DSCAM antisense RNA 1 Homo sapiens 134-138 21236255-2 2011 The transfer of sulfide from the cysteine desulfurase SufS to the scaffold protein SufU is one of the first steps within the assembly process. Sulfides 16-23 SUFU negative regulator of hedgehog signaling Homo sapiens 83-87 21236255-5 2011 Cysteine 41 of SufU is shown to be essential for receiving sulfide from SufS, while cysteines 66 and 128 are needed for SufS/SufU interaction. Sulfides 59-66 SUFU negative regulator of hedgehog signaling Homo sapiens 15-19 20661185-7 2011 Sulfide also lowered the blood IL-6, IL-1beta, and nitrite + nitrate concentrations, which coincided with reduced kidney oxidative DNA base damage and iNOS expression, and attenuated glomerular histological injury as assessed by the incidence of glomerular tubularization. Sulfides 0-7 interleukin 1 beta Homo sapiens 37-45 20661185-7 2011 Sulfide also lowered the blood IL-6, IL-1beta, and nitrite + nitrate concentrations, which coincided with reduced kidney oxidative DNA base damage and iNOS expression, and attenuated glomerular histological injury as assessed by the incidence of glomerular tubularization. Sulfides 0-7 inositol-3-phosphate synthase 1 Homo sapiens 151-155 20661185-8 2011 While expression of heme oxygenase 1 and cleaved caspase 3 did not differ, sulfide reduced the expression Bcl-xL and increased the activation of nuclear transcription factor kappaB. Sulfides 75-82 BCL2 like 1 Homo sapiens 106-112 21141828-2 2011 These sulfides and selenides are isostructural, crystallizing in the triclinic system with space group P1 and Z = 5, in contrast to Tl(4)MTe(4) compounds that adopt space group R3. Sulfides 6-14 crystallin gamma F, pseudogene Homo sapiens 103-115 20632333-10 2010 Complexes 3(rac) and 3(RR) are good catalysts for the sulfoxidation of sulfides providing very good yields and high selectivities with 3(RR) being enantioselective. Sulfides 71-79 AKT serine/threonine kinase 1 Homo sapiens 12-15 21115847-4 2010 The substrate for this reaction, thiophosphate, was synthesized by selenophosphate synthetase 2 from ATP and sulfide and reacted with phosphoseryl-tRNA([Ser]Sec) to generate Cys-tRNA([Ser]Sec). Sulfides 109-116 selenophosphate synthetase 2 Homo sapiens 67-95 21115847-4 2010 The substrate for this reaction, thiophosphate, was synthesized by selenophosphate synthetase 2 from ATP and sulfide and reacted with phosphoseryl-tRNA([Ser]Sec) to generate Cys-tRNA([Ser]Sec). Sulfides 109-116 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 157-160 21115847-4 2010 The substrate for this reaction, thiophosphate, was synthesized by selenophosphate synthetase 2 from ATP and sulfide and reacted with phosphoseryl-tRNA([Ser]Sec) to generate Cys-tRNA([Ser]Sec). Sulfides 109-116 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 188-191 21115847-7 2010 These data reveal a novel Sec machinery-based mechanism for biosynthesis and insertion of Cys into protein at UGA codons and suggest new biological functions for thiophosphate and sulfide in mammals. Sulfides 180-187 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 26-29 20934336-0 2010 Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Sulfides 6-15 tyrosinase Homo sapiens 40-50 20934336-6 2010 The presence of thioether linkage and appropriated lipophilic acid moiety was critical for the tyrosinase inhibitory and anti-inflammatory activities. Sulfides 16-25 tyrosinase Homo sapiens 95-105 20957221-3 2010 Thiolated gonadorelin with affinity for the LHRH receptor was chemically coupled to N-[(3-maleimide-1-oxopropyl) aminopropyl polyethylene glycol-carbamyl] distearoyl-l-phosphatidyl-ethanolamine via a thioether bond and subsequently inserted into polyethylene glycol-grafted liposomes. Sulfides 200-209 gonadotropin releasing hormone 1 Homo sapiens 44-48 20872796-3 2011 The vital cellular functions of the Msr family of genes are to protect cells from oxidative damage by enzymatically reducing the oxidized sulfide groups of methionine residues in proteins from the sulfoxide form (--SO) back to sulfide thus restoring normal protein functions as well as reducing intracellular reactive oxygen species (ROS). Sulfides 138-145 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Mus musculus 36-39 20872796-3 2011 The vital cellular functions of the Msr family of genes are to protect cells from oxidative damage by enzymatically reducing the oxidized sulfide groups of methionine residues in proteins from the sulfoxide form (--SO) back to sulfide thus restoring normal protein functions as well as reducing intracellular reactive oxygen species (ROS). Sulfides 227-234 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Mus musculus 36-39 20591562-2 2010 Volatile sulfide chemicals including methyl thiols, dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide were the dominant odorous contaminants in Lake Taihu and in tap water during the crisis. Sulfides 9-16 nuclear RNA export factor 1 Homo sapiens 174-177 20839838-3 2010 Some of the Ag(2)S nanoparticles (NPs) have excess S on the surface of the sulfide minerals under S-rich environments, resulting in a ratio of Ag to S close to 1. Sulfides 75-82 angiotensin II receptor type 1 Homo sapiens 12-18 20020161-7 2010 The enzymatic activities involved in sulfide oxidation by the colonic epithelial cells appear to be sulfide quinone oxidoreductase considered as the first and rate-limiting step followed presumably by the action of sulfur dioxygenase and rhodanese. Sulfides 37-44 crystallin zeta Homo sapiens 108-130 20714314-1 2010 Lanthionine (Lan), the thioether analog of cystine, is a natural but nonproteogenic amino acid thought to form naturally in mammals through promiscuous reactivity of the transsulfuration enzyme cystathionine-beta-synthase (CbetaS). Sulfides 23-32 cystathionine beta-synthase Homo sapiens 194-221 20657580-1 2010 Ethylmalonic encephalopathy is caused by mutations in ETHE1, a mitochondrial matrix sulfur dioxygenase, leading to failure to detoxify sulfide, a product of intestinal anaerobes and, in trace amounts, tissues. Sulfides 135-142 ETHE1 persulfide dioxygenase Homo sapiens 54-59 20602971-0 2010 Flow injection analysis of ethyl xanthate by gas diffusion and UV detection as CS2 for process monitoring of sulfide ore flotation. Sulfides 109-116 chorionic somatomammotropin hormone 2 Homo sapiens 79-82 20890097-7 2010 MET10 and SSU1 in both strains, but MET16 only in PYCC4072, were consistently up-regulated when sulfide production was inhibited. Sulfides 96-103 sulfite reductase subunit alpha Saccharomyces cerevisiae S288C 0-5 20890097-7 2010 MET10 and SSU1 in both strains, but MET16 only in PYCC4072, were consistently up-regulated when sulfide production was inhibited. Sulfides 96-103 Ssu1p Saccharomyces cerevisiae S288C 10-14 20890097-7 2010 MET10 and SSU1 in both strains, but MET16 only in PYCC4072, were consistently up-regulated when sulfide production was inhibited. Sulfides 96-103 phosphoadenylyl-sulfate reductase (thioredoxin) Saccharomyces cerevisiae S288C 36-41 20522547-5 2010 Frataxin interacts with Isu, iron, and the cysteine desulfurase Nfs1, which supplies sulfide, thus placing it at the center of mitochondrial FeS cluster biosynthesis. Sulfides 85-92 frataxin Homo sapiens 0-8 20522547-5 2010 Frataxin interacts with Isu, iron, and the cysteine desulfurase Nfs1, which supplies sulfide, thus placing it at the center of mitochondrial FeS cluster biosynthesis. Sulfides 85-92 NFS1 cysteine desulfurase Homo sapiens 64-68 20627557-1 2010 A novel series of benzoazepin-2-ones were designed and synthesized targeting the PIF pocket of AGC protein kinases, among which a series of thioether-linked benzoazepin-2-ones were discovered to bind to the PIF pocket of 3-phosphoinositide-dependent kinase-1 (PDK1), and to displace the PIF peptide with an EC(50) values in the lower micromolar range. Sulfides 140-149 PIF1 5'-to-3' DNA helicase Homo sapiens 81-84 20627557-1 2010 A novel series of benzoazepin-2-ones were designed and synthesized targeting the PIF pocket of AGC protein kinases, among which a series of thioether-linked benzoazepin-2-ones were discovered to bind to the PIF pocket of 3-phosphoinositide-dependent kinase-1 (PDK1), and to displace the PIF peptide with an EC(50) values in the lower micromolar range. Sulfides 140-149 PIF1 5'-to-3' DNA helicase Homo sapiens 207-210 20627557-1 2010 A novel series of benzoazepin-2-ones were designed and synthesized targeting the PIF pocket of AGC protein kinases, among which a series of thioether-linked benzoazepin-2-ones were discovered to bind to the PIF pocket of 3-phosphoinositide-dependent kinase-1 (PDK1), and to displace the PIF peptide with an EC(50) values in the lower micromolar range. Sulfides 140-149 pyruvate dehydrogenase kinase 1 Homo sapiens 221-258 20627557-1 2010 A novel series of benzoazepin-2-ones were designed and synthesized targeting the PIF pocket of AGC protein kinases, among which a series of thioether-linked benzoazepin-2-ones were discovered to bind to the PIF pocket of 3-phosphoinositide-dependent kinase-1 (PDK1), and to displace the PIF peptide with an EC(50) values in the lower micromolar range. Sulfides 140-149 pyruvate dehydrogenase kinase 1 Homo sapiens 260-264 20627557-1 2010 A novel series of benzoazepin-2-ones were designed and synthesized targeting the PIF pocket of AGC protein kinases, among which a series of thioether-linked benzoazepin-2-ones were discovered to bind to the PIF pocket of 3-phosphoinositide-dependent kinase-1 (PDK1), and to displace the PIF peptide with an EC(50) values in the lower micromolar range. Sulfides 140-149 PIF1 5'-to-3' DNA helicase Homo sapiens 207-210 20424176-1 2010 The role of sulfite reductase (SiR) in assimilatory reduction of inorganic sulfate to sulfide has long been regarded as insignificant for control of flux in this pathway. Sulfides 86-93 sulfite reductase Arabidopsis thaliana 12-29 20495720-1 2010 The reaction of Ru(3)(CO)(12) in chloroform with thioether ligands after 25 min of irradiation leads to the formation of mononuclear ruthenium(II) complexes of the general formula fac-[Ru(CO)(3)Cl(2)(S)] (S = thioether) if monodentate ligands are introduced. Sulfides 49-58 FA complementation group C Homo sapiens 180-183 20495720-1 2010 The reaction of Ru(3)(CO)(12) in chloroform with thioether ligands after 25 min of irradiation leads to the formation of mononuclear ruthenium(II) complexes of the general formula fac-[Ru(CO)(3)Cl(2)(S)] (S = thioether) if monodentate ligands are introduced. Sulfides 209-218 FA complementation group C Homo sapiens 180-183 20672135-1 2010 Cu2S nanocrystal particles were in situ deposited on graphite paper to prepare nano-sulfide/carbon composite counter electrode for CdS/CdSe quantum-dot-sensitized solar cell (QDSC). Sulfides 84-91 CDP-diacylglycerol synthase 1 Homo sapiens 131-134 20466452-3 2010 The isotopic study revealed denitrification of the NO3-bearing groundwater that takes place through oxidation of the sulphide minerals associated with the gold deposit and leads to anomalous concentrations of some metals such as Zn, Co and Ni. Sulfides 117-125 NBL1, DAN family BMP antagonist Homo sapiens 51-54 20371263-9 2010 SLD sulfide, the toxic metabolite of SLD, enhanced TNF-induced cytotoxicity and caspase 3/7 activity in HepG2 cells. Sulfides 4-11 tumor necrosis factor Homo sapiens 51-54 20371263-9 2010 SLD sulfide, the toxic metabolite of SLD, enhanced TNF-induced cytotoxicity and caspase 3/7 activity in HepG2 cells. Sulfides 4-11 caspase 3 Homo sapiens 80-89 20424176-1 2010 The role of sulfite reductase (SiR) in assimilatory reduction of inorganic sulfate to sulfide has long been regarded as insignificant for control of flux in this pathway. Sulfides 86-93 sulfite reductase Arabidopsis thaliana 31-34 21472225-4 2010 The fundamental defect in EE likely involves the impairment of a mitochondrial sulphur dioxygenase coded by the ETHE1 gene responsible for the catabolism of sulphide, which subsequently accumulates to toxic levels. Sulfides 157-165 ETHE1 persulfide dioxygenase Homo sapiens 112-117 21386213-10 2010 beta-galactosidase activity was positively correlated with malodor strength (organoleptic score, portable sulfide monitor score and VSC concentrations). Sulfides 106-113 galactosidase beta 1 Homo sapiens 0-18 21576865-1 2010 Sulfur-turf microbial mats develop in sulfide-containing hot spring water dominated by chemolithoautotrophic sulfur-oxidizing bacteria. Sulfides 38-45 alcohol dehydrogenase iron containing 1 Homo sapiens 57-60 20014790-3 2010 Here, a thioether-based inhibitor (3) of neuronal nitric oxide synthase (nNOS) was designed, and its binding was characterized by spectrophotometry and crystallography. Sulfides 8-17 nitric oxide synthase 1 Homo sapiens 41-71 20014790-3 2010 Here, a thioether-based inhibitor (3) of neuronal nitric oxide synthase (nNOS) was designed, and its binding was characterized by spectrophotometry and crystallography. Sulfides 8-17 nitric oxide synthase 1 Homo sapiens 73-77 20014790-4 2010 A crystal structure of inhibitor 3 coordinated to heme iron was obtained, representing, to our knowledge, the first crystal structure of a thioether inhibitor complexed to any heme enzyme. Sulfides 139-148 protein phosphatase 1 regulatory inhibitor subunit 11 Homo sapiens 23-34 19671704-3 2009 Here, we show that the distinctive absorption properties of cyanochromes are facilitated through the binding of phycocyanobilin via two stable cysteine-based thioether linkages within the cGMP phosphodiesterase/adenyl cyclase/FhlA domain. Sulfides 158-167 adenylate cyclase 1 Homo sapiens 211-225 19408342-0 2009 Heterogeneity of commercial recombinant human growth hormone (r-hGH) preparations containing a thioether variant. Sulfides 95-104 growth hormone 1 Homo sapiens 46-67 19408342-1 2009 The objective of the present study was to assess (I) the potential presence of a recently discovered thioether variant in commercially available recombinant human growth hormone (r-hGH) preparations, and (II) the impact of the thioether modification on the in-vivo bioactivity and the receptor binding kinetics. Sulfides 101-110 growth hormone 1 Homo sapiens 163-184 19671704-4 2009 Absorption, resonance Raman and infrared spectroscopy, and molecular modeling of the Te-PixJ GAF (cGMP phosphodiesterase/adenyl cyclase/FhlA) domain assembled with phycocyanobilin are consistent with attachments to the C3(1) carbon of the ethylidene side chain and the C4 or C5 carbons in the A-B methine bridge to generate a double thioether-linked phycoviolobilin-type chromophore. Sulfides 333-342 adenylate cyclase 1 Homo sapiens 121-135 19833325-2 2009 Carbocyclic pyranose mimetics (saturated or unsaturated between C-5 and C-5a) are linked by ether, thioether or amine bridges to carbohydrates or other carbasugars. Sulfides 99-108 complement C5 Homo sapiens 64-67 19833325-2 2009 Carbocyclic pyranose mimetics (saturated or unsaturated between C-5 and C-5a) are linked by ether, thioether or amine bridges to carbohydrates or other carbasugars. Sulfides 99-108 complement C5a receptor 1 Homo sapiens 72-76 19786189-6 2009 The calibration was linear for selenium up to 2mgL(-1) and to 10mgL(-1) for sulfide. Sulfides 76-83 LLGL scribble cell polarity complex component 1 Homo sapiens 64-70 19647029-0 2009 Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification? Sulfides 139-146 thiosulfate sulfurtransferase, mitochondrial Mus musculus 0-9 19638570-8 2009 TNF-alpha augmented the cytotoxicity of SLD sulfide in primary hepatocytes and HepG2 cells. Sulfides 44-51 tumor necrosis factor Homo sapiens 0-9 19638570-9 2009 These results suggest that TNF-alpha can enhance SLD sulfide-induced hepatotoxicity, thereby contributing to liver injury in SLD/LPS-cotreated rats. Sulfides 53-60 tumor necrosis factor Rattus norvegicus 27-36 19653802-1 2009 Phenylalanine 4-monooxygenase is the key enzyme in the sulfoxidation of the thioether drug S-carboxymethyl-l-cysteine and its thioether metabolites, S-methyl-l-cysteine, N-acetyl-S-carboxymethyl-l-cysteine and N-acetyl-S-methyl-l-cysteine in humans, and a number of other mammalian species. Sulfides 76-85 phenylalanine hydroxylase Homo sapiens 0-29 19653802-1 2009 Phenylalanine 4-monooxygenase is the key enzyme in the sulfoxidation of the thioether drug S-carboxymethyl-l-cysteine and its thioether metabolites, S-methyl-l-cysteine, N-acetyl-S-carboxymethyl-l-cysteine and N-acetyl-S-methyl-l-cysteine in humans, and a number of other mammalian species. Sulfides 126-135 phenylalanine hydroxylase Homo sapiens 0-29 19682914-1 2009 S-ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether bond of S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), which is the precursor of type 2 autoinducer for bacterial cell-cell communication. Sulfides 61-70 Lutheran suppressor, X-linked Homo sapiens 25-29 19772365-1 2009 To investigate neighboring amide participation in thioether oxidation, which may be relevant to brain oxidative stress accompanying beta-amyloid peptide aggregation, conformationally constrained methylthionorbornyl derivatives with amido moieties were synthesized and characterized, including an X-ray crystallographic study of one of them. Sulfides 50-59 amyloid beta precursor protein Homo sapiens 132-152 19721088-3 2009 These include farnesylation at one vinyl in hemes o and a and thioether linkages to each vinyl in cytochrome c (at CXXCH of the protein). Sulfides 62-71 cytochrome c, somatic Homo sapiens 98-110 19373496-1 2009 Recent crystal structures of cysteine dioxygenase (CDO) suggest the presence of two posttranslational modifications adjacent to the catalytic iron center: a thioether cross-link between Cys93 and Tyr157 and extra electron density at Cys164 which was variously explained as cystine or cysteine sulfinic acid. Sulfides 157-166 cysteine dioxygenase type 1 Rattus norvegicus 29-49 19722697-3 2009 This C-terminal domain contains a pair of redox active cysteines and demonstrates thioredoxin-like activity by both binding to and mediating persulfide bond cleavage of sulfur-loaded IscS, the sulfide donor for [2Fe-2S] cluster assembly on ISU-type scaffold proteins. Sulfides 144-151 NFS1 cysteine desulfurase Homo sapiens 183-187 20111690-1 2009 A conformational analysis of nine macrocyclic thioether musks has been carried out using molecular mechanics (MMFF), density functional theory (DFT) using both B3LYP and M06 functionals, as well as Hartree-Fock and post-Hartree-Fock (MP2) ab initio methods. Sulfides 46-55 tryptase pseudogene 1 Homo sapiens 234-237 19373496-1 2009 Recent crystal structures of cysteine dioxygenase (CDO) suggest the presence of two posttranslational modifications adjacent to the catalytic iron center: a thioether cross-link between Cys93 and Tyr157 and extra electron density at Cys164 which was variously explained as cystine or cysteine sulfinic acid. Sulfides 157-166 cysteine dioxygenase type 1 Rattus norvegicus 51-54 19503889-0 2009 One-pot oxidation and protonation of a bridging sulfide and rare crystallographic evidence of a coordinated [SO] complex in [Pt2(micro-S2O2H)(PPh3)4]+. Sulfides 48-55 caveolin 1 Homo sapiens 142-146 19398200-2 2009 Optimization of 1 by introduction of a hydrophilic substituent into the thioether part resulted in identification of potent ORL1 antagonists with high selectivity over binding affinity for hERG and other opioid receptors. Sulfides 72-81 opioid related nociceptin receptor 1 Homo sapiens 124-128 19070955-1 2009 Acid mine drainage (AMD) is often accompanied with elevated concentrations of arsenic, in the forms of arsenite, As(III), and/or arsenate, As(V), due to the high affinity of arsenic for sulfide mineral ores. Sulfides 186-193 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 139-144 19398200-2 2009 Optimization of 1 by introduction of a hydrophilic substituent into the thioether part resulted in identification of potent ORL1 antagonists with high selectivity over binding affinity for hERG and other opioid receptors. Sulfides 72-81 ETS transcription factor ERG Homo sapiens 189-193 19557339-0 2009 Microbial diversity of a sulfide black smoker in main endeavour hydrothermal vent field, Juan de Fuca Ridge. Sulfides 25-32 alpha-L-fucosidase 1 Homo sapiens 97-101 19296828-5 2009 LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM). Sulfides 171-178 cystathionine beta-synthase Homo sapiens 3-6 19296828-5 2009 LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM). Sulfides 171-178 cystathionine beta-synthase Homo sapiens 17-20 19534160-4 2009 Three valence states of S (-II), S (0), and S (+VI) were discovered from the sulfide oxidation, and So, Sx(2-), S4O6(2-), S2O3(2-), and SO4(2-) were detected as the intermediates. Sulfides 77-84 transcription elongation factor A1 Homo sapiens 24-30 19038778-3 2009 Here, we describe the enzymatic introduction of a thioether ring in angiotensin [Ang-(1-7)], a heptapeptide that plays a pivotal role in the renin-angiotensin system and possesses important therapeutic activities. Sulfides 50-59 renin Rattus norvegicus 141-146 19127528-1 2009 Theoretical energy-based conformational analysis of bis(2-phenethyl)vinylphosphine and related phosphine oxide, sulfide and selenide synthesized from available secondary phosphine chalcogenides and vinyl sulfoxides is performed at the MP2/6-311G** level to study stereochemical behavior of their (31)P-(1)H spin-spin coupling constants measured experimentally and calculated at different levels of theory. Sulfides 112-119 major intrinsic protein of lens fiber Homo sapiens 235-240 19127528-1 2009 Theoretical energy-based conformational analysis of bis(2-phenethyl)vinylphosphine and related phosphine oxide, sulfide and selenide synthesized from available secondary phosphine chalcogenides and vinyl sulfoxides is performed at the MP2/6-311G** level to study stereochemical behavior of their (31)P-(1)H spin-spin coupling constants measured experimentally and calculated at different levels of theory. Sulfides 112-119 minichromosome maintenance complex component 3 Homo sapiens 300-306 19059469-2 2009 Disulfide and thioether linked conjugates were prepared by coupling Cyt c to cysteinyl-nonaarginine, C(R)(9), through SPDP and SMPB cross-linkers, respectively. Sulfides 14-23 cytochrome c, somatic Homo sapiens 68-73 19059469-5 2009 However, the biological activity of the internalized Cyt c, indicated by apoptosis in HeLa cells, was expressed only in the thioether (SMPB) conjugate, but not the disulfide (SPDP) conjugate or free Cyt c. Sulfides 124-133 cytochrome c, somatic Homo sapiens 53-58 19146390-3 2009 This C-terminal domain contains a pair of redox active cysteines and demonstrates thioredoxin-like activity by mediating persulfide bond cleavage of sulfur-loaded NifS (an IscS-type protein), the sulfide donor for [2Fe-2S] cluster assembly on ISU-type scaffold proteins. Sulfides 124-131 NFS1 cysteine desulfurase Homo sapiens 163-167 19136963-0 2009 Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy. Sulfides 57-64 ethylmalonic encephalopathy 1 Mus musculus 8-13 19136963-7 2009 High thiosulfate and sulfide concentrations were present in Ethe1(-/-) mouse tissues. Sulfides 21-28 ethylmalonic encephalopathy 1 Mus musculus 60-65 19136963-11 2009 Therefore, ETHE1 is a mitochondrial sulfur dioxygenase involved in catabolism of sulfide that accumulates to toxic levels in ethylmalonic encephalopathy. Sulfides 81-88 ethylmalonic encephalopathy 1 Mus musculus 11-16 19011861-1 2009 O-acetylserine(thiol) lyase (OASTL), a key enzyme of the plant sulfur assimilatory pathway, catalyses the formation of cysteine from sulfide and O-acetylserine. Sulfides 133-140 cysteine synthase Triticum aestivum 0-27 19099445-1 2009 S-Ribosylhomocysteinase (LuxS) cleaves the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine (Hcys) and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of the type II bacterial quorum sensing molecule (AI-2). Sulfides 43-52 Lutheran suppressor, X-linked Homo sapiens 25-29 19011861-1 2009 O-acetylserine(thiol) lyase (OASTL), a key enzyme of the plant sulfur assimilatory pathway, catalyses the formation of cysteine from sulfide and O-acetylserine. Sulfides 133-140 cysteine synthase Triticum aestivum 29-34 18608740-4 2008 The xenobiotic thioether substrates (SMC and SCMC) were predicted to be poor substrates for PAH by the molecular modelling investigation and this has now been confirmed by the in vitro enzyme kinetic data. Sulfides 15-24 phenylalanine hydroxylase Homo sapiens 92-95 18407378-2 2009 Firstly, the o-carborane cage was linked to quinazoline at C-2 position via thioether linker: 2-S-(1,2-dicarba-closo-dodecaboran(12)-1-ylmethyl)-3-phenylquinazolin-4(3H)-one. Sulfides 76-85 complement component 2 (within H-2S) Mus musculus 59-62 19380997-2 2009 It is based on two kinetic equations able to describe the simultaneous microbial consumption of oxygen and sulfide (OUR and SUR) as a function of a particular sulfide-oxidizing microorganism or its physiological state, these can be characterized by the assessment of their kinetic constants. Sulfides 107-114 ATP binding cassette subfamily C member 8 Homo sapiens 124-127 19380997-2 2009 It is based on two kinetic equations able to describe the simultaneous microbial consumption of oxygen and sulfide (OUR and SUR) as a function of a particular sulfide-oxidizing microorganism or its physiological state, these can be characterized by the assessment of their kinetic constants. Sulfides 159-166 ATP binding cassette subfamily C member 8 Homo sapiens 124-127 19380997-4 2009 The ratio OUR/SUR was proposed to predict the sulfide oxidation extent and then the fate of sulfide to elemental sulfur and sulfate. Sulfides 46-53 ATP binding cassette subfamily C member 8 Homo sapiens 14-17 19380997-4 2009 The ratio OUR/SUR was proposed to predict the sulfide oxidation extent and then the fate of sulfide to elemental sulfur and sulfate. Sulfides 92-99 ATP binding cassette subfamily C member 8 Homo sapiens 14-17 18796394-2 2009 Closely related genera Idas and Adipicola are associated with organic falls, ecosystems that have been suggested as potential evolutionary "stepping stones" in the colonization of deeper and more sulphide-rich environments. Sulfides 196-204 multiciliate differentiation and DNA synthesis associated cell cycle protein Homo sapiens 23-27 23045014-4 2009 Like the cytochrome P450 system, PAH is able to oxidize both aliphatic and aromatic carbon centers in addition to undertaking the S-oxidation of aliphatic thioethers (including the two mucoactive drugs S-carboxymethyl-L-cysteine and S-methyl-L-cysteine). Sulfides 155-165 phenylalanine hydroxylase Homo sapiens 33-36 18997406-6 2008 The addition of GSH or NAC completely suppressed the sulfide-induced apoptosis. Sulfides 53-60 synuclein alpha Homo sapiens 23-26 21832695-1 2008 We describe a lead sulfide nanoparticle (PbS NP)-based electrochemical immunoassay to detect a tumor biomarker, carcinoembryonic antigen (CEA). Sulfides 19-26 CEA cell adhesion molecule 3 Homo sapiens 112-136 18678619-3 2008 SUL and/or IND significantly increased annexin V-positive cells, cleaved poly(ADP-ribose) polymerase (PARP) and caspase-3. Sulfides 0-3 poly(ADP-ribose) polymerase 1 Homo sapiens 73-100 18678619-3 2008 SUL and/or IND significantly increased annexin V-positive cells, cleaved poly(ADP-ribose) polymerase (PARP) and caspase-3. Sulfides 0-3 poly(ADP-ribose) polymerase 1 Homo sapiens 102-106 18678619-3 2008 SUL and/or IND significantly increased annexin V-positive cells, cleaved poly(ADP-ribose) polymerase (PARP) and caspase-3. Sulfides 0-3 caspase 3 Homo sapiens 112-121 18678619-6 2008 SUL, IND, and ASA (5 mM) suppressed PPARdelta and 14-3-3 proteins in a manner parallel to PARP cleavage. Sulfides 0-3 peroxisome proliferator activated receptor delta Homo sapiens 36-45 18678619-6 2008 SUL, IND, and ASA (5 mM) suppressed PPARdelta and 14-3-3 proteins in a manner parallel to PARP cleavage. Sulfides 0-3 poly(ADP-ribose) polymerase 1 Homo sapiens 90-94 18678619-8 2008 SUL inhibited PPARdelta promoter activity, which correlated with 14-3-3epsilon promoter suppression. Sulfides 0-3 peroxisome proliferator activated receptor delta Homo sapiens 14-23 18678619-8 2008 SUL inhibited PPARdelta promoter activity, which correlated with 14-3-3epsilon promoter suppression. Sulfides 0-3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Homo sapiens 65-78 18816537-6 2008 SAR for aromatase inhibition shows that compounds containing an alkylene- and thioether-based linker system are more potent than those that are ether-, sulfone-, or sulfonamide-based, and that the length of the linker has a limited effect on aromatase inhibition beyond two methylene units. Sulfides 78-87 sarcosine dehydrogenase Homo sapiens 0-3 21832695-1 2008 We describe a lead sulfide nanoparticle (PbS NP)-based electrochemical immunoassay to detect a tumor biomarker, carcinoembryonic antigen (CEA). Sulfides 19-26 CEA cell adhesion molecule 3 Homo sapiens 138-141 18281275-10 2008 This, in turn, facilitates an intermediate thioether bond between Cys-143 and Ile-142, the site of AC cleavage. Sulfides 43-52 N-acylsphingosine amidohydrolase 1 Homo sapiens 99-101 18294843-6 2008 The use of LctM to prepare thioether containing analogs of enkephalin, contryphan, and inhibitors of human tripeptidyl peptidase II and spider venom epimerase is demonstrated. Sulfides 27-36 tripeptidyl peptidase 2 Homo sapiens 107-131 17975847-13 2008 We found a high level of similarity between the binding properties of the 40-mer peptides with amide or thioether links, providing a new possibility to build up oligomeric MUC1 peptides by thioether bond formation. Sulfides 104-113 mucin 1, cell surface associated Homo sapiens 172-176 17975847-13 2008 We found a high level of similarity between the binding properties of the 40-mer peptides with amide or thioether links, providing a new possibility to build up oligomeric MUC1 peptides by thioether bond formation. Sulfides 189-198 mucin 1, cell surface associated Homo sapiens 172-176 18710273-4 2008 Here, we report the synthesis of a peptide targeted polyglutamic acid polymer in which the high affinity alpha(v)beta(6)-specific tetrameric H2009.1 peptide is incorporated via a thioether at the N-terminus of a 15 amino acid polymer of glutamic acid. Sulfides 179-188 integrin subunit alpha V Homo sapiens 111-112 18494801-3 2008 A membrane-bound sulfide : quinone oxidoreductase converts sulfide to persulfides and transfers the electrons to the ubiquinone pool. Sulfides 17-24 crystallin zeta Homo sapiens 27-49 18494801-3 2008 A membrane-bound sulfide : quinone oxidoreductase converts sulfide to persulfides and transfers the electrons to the ubiquinone pool. Sulfides 59-66 crystallin zeta Homo sapiens 27-49 18494801-5 2008 The final reaction is catalyzed by a sulfur transferase, which adds a second persulfide from the sulfide : quinone oxidoreductase to sulfite, resulting in the final product thiosulfate. Sulfides 80-87 crystallin zeta Homo sapiens 107-129 18489753-13 2008 As the hydrothermal fluids mix with the ambient seawater, Zn-sulfide clusters and nanoparticles are likely preventing sulfide oxidation by O2 and reducing bioavailability of S(-II) to organisms. Sulfides 61-68 transcription elongation factor A1 Homo sapiens 174-179 17551834-2 2008 RESULTS: Gel filtration of colonic mucosa and purified bovine rhodanese showed that rhodanese and sulfide oxidizing activities resided in different proteins. Sulfides 98-105 thiosulfate sulfurtransferase Bos taurus 62-71 18454048-7 2008 In addition, pharmacological inhibition of poly(ADP-ribose) polymerase-1activity moderately enhanced cytotoxic activity of sulfide 9-anilinoacridine, suggesting that poly(ADP-ribose) polymerase-1 may have a protective function against 9-anilinoacridine-induced cell death process. Sulfides 123-130 poly (ADP-ribose) polymerase family, member 1 Mus musculus 43-72 18454048-7 2008 In addition, pharmacological inhibition of poly(ADP-ribose) polymerase-1activity moderately enhanced cytotoxic activity of sulfide 9-anilinoacridine, suggesting that poly(ADP-ribose) polymerase-1 may have a protective function against 9-anilinoacridine-induced cell death process. Sulfides 123-130 poly (ADP-ribose) polymerase family, member 1 Mus musculus 166-195 18185871-1 2008 The first thioether complexes of the hard Lewis acidic GeF(4) and SnF(4) have been prepared by reaction of [GeF(4)(MeCN)(2)] or [SnF(4)(MeCN)(2)] respectively with the thioether ligand in rigorously anhydrous CH(2)Cl(2) solution. Sulfides 10-19 Rho guanine nucleotide exchange factor 4 Homo sapiens 55-61 18185871-1 2008 The first thioether complexes of the hard Lewis acidic GeF(4) and SnF(4) have been prepared by reaction of [GeF(4)(MeCN)(2)] or [SnF(4)(MeCN)(2)] respectively with the thioether ligand in rigorously anhydrous CH(2)Cl(2) solution. Sulfides 10-19 Rho guanine nucleotide exchange factor 4 Homo sapiens 108-114 18185871-1 2008 The first thioether complexes of the hard Lewis acidic GeF(4) and SnF(4) have been prepared by reaction of [GeF(4)(MeCN)(2)] or [SnF(4)(MeCN)(2)] respectively with the thioether ligand in rigorously anhydrous CH(2)Cl(2) solution. Sulfides 168-177 Rho guanine nucleotide exchange factor 4 Homo sapiens 55-61 18338852-4 2008 We have used this method to convert human urotensin II, known as a potent vasoconstrictor, to its analogue containing a thioether bond, showing that this new analogue retains biological activity. Sulfides 120-129 urotensin 2 Homo sapiens 42-54 18261510-8 2008 For both methods the linear response was found to range from 5microgL(-1) to 25mgL(-1) of sulfide. Sulfides 90-97 LLGL scribble cell polarity complex component 1 Homo sapiens 79-85 17551834-3 2008 In the presence of cyanide, rhodanese shifted the major mucosal metabolite of sulfide from thiosulfate to thiocyanate. Sulfides 78-85 thiosulfate sulfurtransferase Rattus norvegicus 28-37 17551834-4 2008 The purported ability of purified rhodanese to metabolize sulfide reflects: (a) contamination with a sulfide oxidase, and (b) the spontaneous conversion of sulfide to thiosulfate during storage; rhodanese then catalyzes the conversion of this thiosulfate to thiocyanate. Sulfides 58-65 thiosulfate sulfurtransferase Rattus norvegicus 34-43 17551834-4 2008 The purported ability of purified rhodanese to metabolize sulfide reflects: (a) contamination with a sulfide oxidase, and (b) the spontaneous conversion of sulfide to thiosulfate during storage; rhodanese then catalyzes the conversion of this thiosulfate to thiocyanate. Sulfides 58-65 thiosulfate sulfurtransferase Rattus norvegicus 195-204 17551834-4 2008 The purported ability of purified rhodanese to metabolize sulfide reflects: (a) contamination with a sulfide oxidase, and (b) the spontaneous conversion of sulfide to thiosulfate during storage; rhodanese then catalyzes the conversion of this thiosulfate to thiocyanate. Sulfides 101-108 thiosulfate sulfurtransferase Rattus norvegicus 34-43 17904100-5 2007 Met25 is an enzyme that catalyzes the synthesis of homocysteine from sulfide (S(2-)) and O-acetylhomocysteine and we detected the increased production of S(2-) upon overexpression of Cdc34. Sulfides 69-76 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Saccharomyces cerevisiae S288C 0-5 18186335-2 2007 The DGT-CID technique precipitates and immobilizes the net pore-water flux of dissolved sulfide as black Ag2S by reaction with a AgI binding gel. Sulfides 88-95 angiotensin II receptor type 1 Homo sapiens 105-109 17904100-5 2007 Met25 is an enzyme that catalyzes the synthesis of homocysteine from sulfide (S(2-)) and O-acetylhomocysteine and we detected the increased production of S(2-) upon overexpression of Cdc34. Sulfides 69-76 SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 Saccharomyces cerevisiae S288C 183-188 17710451-8 2007 The calculations collectively support the experimentally observed substitution of thioethers from Pt(II) complexes by N7-GMP. Sulfides 82-92 5'-nucleotidase, cytosolic II Homo sapiens 121-124 17955129-12 2007 The generation of TiS(2), SnS(2) and SnS in this way are very rare examples of metal sulfide deposition from C-S bond fission within a thioether complex. Sulfides 135-144 sodium voltage-gated channel alpha subunit 11 Homo sapiens 26-32 17722900-5 2007 The tolerance for nonhydrophilic thioether substituents in the 6-position opens up the possibility of developing new sensitive positron emission tomography radioligands for imaging human Abeta plaques in Alzheimer"s disease, especially in view of the amenability of thioethers to be labeled with carbon-11 or fluorine-18 through S-alkylation reactions. Sulfides 33-42 amyloid beta precursor protein Homo sapiens 187-192 17920289-4 2007 The ion [2h + H - NH(3)](+) also was generated from the acyclic precursor 5-cyanoamino-4-oxomethylene-dihydroimidazole 13h and from the thioether derivative 14h of 2h (NH(2) replaced by MeS). Sulfides 136-145 MKS transition zone complex subunit 1 Homo sapiens 186-189 17722900-5 2007 The tolerance for nonhydrophilic thioether substituents in the 6-position opens up the possibility of developing new sensitive positron emission tomography radioligands for imaging human Abeta plaques in Alzheimer"s disease, especially in view of the amenability of thioethers to be labeled with carbon-11 or fluorine-18 through S-alkylation reactions. Sulfides 266-276 amyloid beta precursor protein Homo sapiens 187-192 17696546-1 2007 The synthesis of N-cyanosulfilimines can readily be achieved by reaction of the corresponding sulfides with cyanogen amine in the presence of a base and NBS or I2 as halogenating agents. Sulfides 94-102 nibrin Homo sapiens 153-156 17822122-7 2007 Analysis byXPS indicated that PdS and In2S3 complexes form during sulfide fouling, where sulfur is present as S2-, and that regeneration with sodium hypochlorite converts a portion of the S2- to S6+, with a corresponding increase in reduction rates. Sulfides 66-73 solute carrier family 26 member 4 Homo sapiens 30-33 17295113-6 2007 However, the reducible and organic and sulfide components also act as major sinks for metals in the down stretches of the river, which is supported by the high GAI and MEF values. Sulfides 39-46 E74 like ETS transcription factor 4 Homo sapiens 168-171 17655306-4 2007 Alkyl secondary and tertiary allylic disulfides, formed by sulfide transfer from allylic heteroaryl disulfides to thiols, undergo desulfurative allylic rearrangement on treatment with PPh3 in methanolic acetonitrile at room temperature. Sulfides 39-46 caveolin 1 Homo sapiens 184-188 17362001-1 2007 Two flexible thioether-containing heterocyclic ligands bis(2-pyrazylmethyl)sulfide (L1) and 2-benzylsulfanylmethylpyrazine (L2) have arene rings with differing pi-acidities which were used to probe anion-pi binding in five 1-D coordination polymers formed from the metal salts Co(ClO4)2, Ni(NO3)2, and Cd(NO3)2. Sulfides 13-22 NBL1, DAN family BMP antagonist Homo sapiens 291-294 17212981-2 2007 An anti-EGFR antibody (cetuximab or C225) was covalently linked to FBP via a thioether bond. Sulfides 77-86 epidermal growth factor receptor Homo sapiens 8-12 17212981-2 2007 An anti-EGFR antibody (cetuximab or C225) was covalently linked to FBP via a thioether bond. Sulfides 77-86 folate receptor beta Homo sapiens 67-70 17245576-0 2007 Effect of nitrate and nitrite on sulfide production by two thermophilic, sulfate-reducing enrichments from an oil field in the North Sea. Sulfides 33-40 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 133-136 17452108-2 2007 Thioetherification reaction of 4 or 5 with an organic halide catalyzed by indium or indium tribromide first affords appropriate sulfide 7 or 8, which is then converted into title compounds 9 or 10 by hydrogen peroxide oxidation catalyzed by ammonium molybdate in ionic liquid [bmim]PF6. Sulfides 128-135 sperm associated antigen 17 Homo sapiens 282-285 17571057-6 2007 The rabeprazole metabolism is different from the other molecules of the same category in that it only moderately involves the CYP450 (CYP3A4 and CYP2C19) from the moment its metabolization begins through nonenzymatic routes and 80% is involved in a thioether non enzymatic reduction mechanism. Sulfides 249-258 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 134-140 17434203-4 2007 The stepwise decrease of the sulfide concentrations in the reactors with a COD/SO(4)(2-) ratio of 1 by N(2) stripping caused an immediate stepwise increase in the sulfate reduction efficiencies, indicating a reversible inhibition by sulfide. Sulfides 29-36 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 75-78 17434203-4 2007 The stepwise decrease of the sulfide concentrations in the reactors with a COD/SO(4)(2-) ratio of 1 by N(2) stripping caused an immediate stepwise increase in the sulfate reduction efficiencies, indicating a reversible inhibition by sulfide. Sulfides 233-240 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 75-78 17434203-6 2007 Acidifying sludge pre-grown at pH 6, at a COD/SO(4)(2-) ratio of 9 and exposed for 150 days to 115 mg l(-1) sulfide, showed a slower recovery from the sulfide inhibition than a freshly harvested sludge from a full scale treatment plant (pH 7 and COD/SO(4)(2-)=9.5) exposed for a 70 days to 200 mg l(-1) sulfide. Sulfides 108-115 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 246-249 17434203-6 2007 Acidifying sludge pre-grown at pH 6, at a COD/SO(4)(2-) ratio of 9 and exposed for 150 days to 115 mg l(-1) sulfide, showed a slower recovery from the sulfide inhibition than a freshly harvested sludge from a full scale treatment plant (pH 7 and COD/SO(4)(2-)=9.5) exposed for a 70 days to 200 mg l(-1) sulfide. Sulfides 151-158 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 246-249 17434203-6 2007 Acidifying sludge pre-grown at pH 6, at a COD/SO(4)(2-) ratio of 9 and exposed for 150 days to 115 mg l(-1) sulfide, showed a slower recovery from the sulfide inhibition than a freshly harvested sludge from a full scale treatment plant (pH 7 and COD/SO(4)(2-)=9.5) exposed for a 70 days to 200 mg l(-1) sulfide. Sulfides 151-158 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 246-249 17425719-5 2007 The transcript of sulfite reductase, a chloroplast-localized enzyme that reduces sulfites to sulfides, was shown to be rapidly induced by SO(2) in a sulfite oxidase-dependent manner. Sulfides 93-101 sulfite reductase Arabidopsis thaliana 18-35 17425719-5 2007 The transcript of sulfite reductase, a chloroplast-localized enzyme that reduces sulfites to sulfides, was shown to be rapidly induced by SO(2) in a sulfite oxidase-dependent manner. Sulfides 93-101 sulfite oxidase Arabidopsis thaliana 138-140 17425719-5 2007 The transcript of sulfite reductase, a chloroplast-localized enzyme that reduces sulfites to sulfides, was shown to be rapidly induced by SO(2) in a sulfite oxidase-dependent manner. Sulfides 93-101 sulfite oxidase Arabidopsis thaliana 149-164 17362001-1 2007 Two flexible thioether-containing heterocyclic ligands bis(2-pyrazylmethyl)sulfide (L1) and 2-benzylsulfanylmethylpyrazine (L2) have arene rings with differing pi-acidities which were used to probe anion-pi binding in five 1-D coordination polymers formed from the metal salts Co(ClO4)2, Ni(NO3)2, and Cd(NO3)2. Sulfides 13-22 NBL1, DAN family BMP antagonist Homo sapiens 305-308 17198412-1 2007 We have recently reported that aquo and thioether complexes of the ferric cytochrome c heme peptide N-acetylmicroperoxidase-8 (FeIII-1) exhibit greater low-spin character than do the corresponding complexes of a synthetic, water-soluble, monohistidine-ligated heme peptide (FeIII-2; Cowley, A. Sulfides 40-49 cytochrome c, somatic Homo sapiens 74-86 17305318-5 2007 LanCL1 is a mammalian homologue of a prokaryotic enzyme responsible for the synthesis of thioether (lanthionine) cross-links within nascent polypeptide chains, yielding macrocyclic proteins with potent microbicidal activity. Sulfides 89-98 LanC like 1 Homo sapiens 0-6 17371503-1 2007 Sulfite reductase (SiR) is an important enzyme catalyzing the reduction of sulfite to sulfide during sulfur assimilation in plants. Sulfides 86-93 sulfite reductase [ferredoxin], chloroplastic Zea mays 0-17 17371503-1 2007 Sulfite reductase (SiR) is an important enzyme catalyzing the reduction of sulfite to sulfide during sulfur assimilation in plants. Sulfides 86-93 sulfite reductase [ferredoxin], chloroplastic Zea mays 19-22 16979290-5 2007 Strain SA2 used thiosulfate, sulfate, sulfite and elemental sulfur as electron acceptors and produced sulfide. Sulfides 102-109 stromal antigen 2 Homo sapiens 7-10 16979290-6 2007 Strain SA2 reduced sulfate contained in 1-20g/L phosphogypsum to sulfide with reduction of sulfate contained in 2g/L phosphogypsum being the optimum concentration. Sulfides 65-72 stromal antigen 2 Homo sapiens 7-10 17713212-6 2007 This indicates that the elevated concentration of sulfide is the only limiting factor to BEX biodegradation at this site under anaerobic conditions and that treating the groundwater with FeCl2 may be a simple remedy to both facilitate and enhance BEX degradation by the indigenous SRB population. Sulfides 50-57 brain expressed X-linked 3 Homo sapiens 89-92 17713212-6 2007 This indicates that the elevated concentration of sulfide is the only limiting factor to BEX biodegradation at this site under anaerobic conditions and that treating the groundwater with FeCl2 may be a simple remedy to both facilitate and enhance BEX degradation by the indigenous SRB population. Sulfides 50-57 brain expressed X-linked 3 Homo sapiens 247-250 17177418-10 2006 The 10(2)-10(4)-fold increase in the rate of Trx reduction by the seleno-Grx3 analogues demonstrates that oxidoreductases containing either selenenyl-sulfide or diselenide bonds can have physiologically compatible redox potentials and enhanced reduction kinetics in comparison with their sulfide counterparts. Sulfides 150-157 thioredoxin Homo sapiens 45-48 17546719-0 2007 Synthetic vaccines of tumor-associated glycopeptide antigens by immune-compatible thioether linkage to bovine serum albumin. Sulfides 82-91 albumin Homo sapiens 110-123 17181246-6 2006 Each of the two remaining Cd2+ ions bonds radially through a 6-ring of the zeolite framework to a sulfide ion of this Cd4S4 unit (Cd-S = 2.90(8) A). Sulfides 98-105 CDP-diacylglycerol synthase 1 Homo sapiens 130-134 18029734-3 2007 We have previously described that the sulfide derivatives (1) of 2-amino-6-vinyl purine nucleoside (2, AVP) are activated within duplex to form cross-link toward cytidine selectively at the target site. Sulfides 38-45 arginine vasopressin Homo sapiens 103-106 17177418-10 2006 The 10(2)-10(4)-fold increase in the rate of Trx reduction by the seleno-Grx3 analogues demonstrates that oxidoreductases containing either selenenyl-sulfide or diselenide bonds can have physiologically compatible redox potentials and enhanced reduction kinetics in comparison with their sulfide counterparts. Sulfides 150-157 glutaredoxin 3 Homo sapiens 73-77 16934831-6 2006 The results provide definitive evidence for sulfide as the endogenous TSOX ligand and strongly suggest that the modified FMN is a 4a-sulfide adduct. Sulfides 44-51 formin 1 Homo sapiens 121-124 16966321-15 2006 Reaction of the alkylnickel intermediate with thiols regenerates the active MCR(red1) state and eliminates the propylsulfonate group, presumably as the thioether. Sulfides 152-161 adenosine deaminase RNA specific B1 Homo sapiens 80-84 16500920-8 2006 Sulfide (0.1 mM) also increased TST activity, but higher sulfide concentrations (0.3-3 mM) were toxic. Sulfides 0-7 thiosulfate sulfurtransferase Homo sapiens 32-35 16624372-2 2006 Temperature and pH optima studies showed temperature optima of 50 degrees C and pH optima of 8.0 for the alpha-glucosidases from both the MR and SR. Sulfide (at a concentration of 150 mg l(-1)) resulted in the complete loss of all alpha-glucosidase activity in both the MR and SR. beta-Glucosidase activities in our bioreactors were previously shown to be stimulated in the presence of sulfide. Sulfides 149-156 sucrase-isomaltase Homo sapiens 105-122 16624372-2 2006 Temperature and pH optima studies showed temperature optima of 50 degrees C and pH optima of 8.0 for the alpha-glucosidases from both the MR and SR. Sulfide (at a concentration of 150 mg l(-1)) resulted in the complete loss of all alpha-glucosidase activity in both the MR and SR. beta-Glucosidase activities in our bioreactors were previously shown to be stimulated in the presence of sulfide. Sulfides 386-393 sucrase-isomaltase Homo sapiens 105-122 16624372-4 2006 This differential effect of sulfide on alpha-glucosidase and beta-glucosidase activities is highlighted and is of crucial consequence to the respective degradation and utilization of starch and cellulose substrates in natural anaerobic environments and anaerobic bioreactors specifically designed for the accelerated digestion of wastewater sludge under biosulfidogenic conditions. Sulfides 28-35 sucrase-isomaltase Homo sapiens 39-56 16787928-1 2006 In prokaryotes and yeast, the general mechanism of biogenesis of iron-sulfur (Fe-S) clusters involves activities of several proteins among which IscS and Nfs1p provide, through cysteine desulfuration, elemental sulfide for Fe-S core formation. Sulfides 211-218 cysteine desulfurase Saccharomyces cerevisiae S288C 154-159 16930022-7 2006 Introduction via a thioether linkage was performed by a facile nucleophilic aromatic substitution between the brominated EDOT aldehyde and unprotected mercapto acids to provide T-BAL2 and T-BAL3 handles. Sulfides 19-28 poly(ADP-ribose) polymerase family member 14 Homo sapiens 179-183 16913707-7 2006 The strongest interacting thioether bound preferentially to the poly(dA) x [poly(dT)]2 triplex, K(app) = 1.6 x 10(5) M(-1) (40 x K(app) for CT DNA duplex). Sulfides 26-35 X-prolyl aminopeptidase 1 Homo sapiens 96-106 16755125-9 2006 Such a difference in the AUC between rabeprazole enantiomers is likely to be dependent on stereoselectivity in the CYP3A4-mediated metabolic conversion from rabeprazole-thioether to rabeprazole. Sulfides 169-178 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 115-121 16674058-1 2006 A new flavin catalyst 2 immobilized in an ionic liquid ([BMIm]PF6) was used for the highly selective oxidation of sulfides to sulfoxides by hydrogen peroxide. Sulfides 114-122 sperm associated antigen 17 Homo sapiens 62-65 16686542-1 2006 S-Ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether linkage in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione, the precursor of autoinducer 2. Sulfides 61-70 Lutheran suppressor, X-linked Homo sapiens 25-29 16431909-3 2006 In the absence of chaperones, the kinetics of Fe/S cluster formation on Isu1p were compatible with a chemical reconstitution pathway with Nfs1p functioning as a sulfide donor. Sulfides 161-168 iron-binding protein ISU1 Saccharomyces cerevisiae S288C 72-77 16719114-6 2006 Sulfite, sulfide, and elevated chloride decreased the NO3- reduction rate by over 2 orders of magnitude. Sulfides 9-16 NBL1, DAN family BMP antagonist Homo sapiens 54-57 16431909-3 2006 In the absence of chaperones, the kinetics of Fe/S cluster formation on Isu1p were compatible with a chemical reconstitution pathway with Nfs1p functioning as a sulfide donor. Sulfides 161-168 NFS1 cysteine desulfurase Homo sapiens 138-143 16411783-7 2006 The GTSTG active site and large flanking regions of sequence are not modified by BEL treatment, but most iPLA2beta Cys residues are alkylated at various BEL concentrations to form a thioether linkage to a BEL keto acid hydrolysis product. Sulfides 182-191 phospholipase A2 group VI Homo sapiens 105-114 16522125-1 2006 The activation of dioxygen by dopamine beta-monooxygenase (DbetaM) and peptidylglycine alpha-hydroxylating monooxygenase (PHM) is postulated to occur at a copper site ligated by two histidine imidazoles and a methionine thioether, which is unusual because such thioether ligation is not present in other O2-activating copper proteins. Sulfides 220-229 peptidylglycine alpha-amidating monooxygenase Homo sapiens 71-120 16522125-1 2006 The activation of dioxygen by dopamine beta-monooxygenase (DbetaM) and peptidylglycine alpha-hydroxylating monooxygenase (PHM) is postulated to occur at a copper site ligated by two histidine imidazoles and a methionine thioether, which is unusual because such thioether ligation is not present in other O2-activating copper proteins. Sulfides 220-229 peptidylglycine alpha-amidating monooxygenase Homo sapiens 122-125 16522125-12 2006 A role for the thioether in promoting loss of O2 from the 1:1 Cu/O2 adduct and facilitating trapping of the resulting Cu(I) complex to yield the bis(mu-oxo) species is proposed, and the possible relevance of this role to that of the methionine in the active sites of DbetaM and PHM is discussed. Sulfides 15-24 peptidylglycine alpha-amidating monooxygenase Homo sapiens 278-281 16486600-1 2006 Direct in situ studies of the surface diffusion of isolated adsorbates at an electrochemical interface by high-speed scanning tunneling microscopy (video STM) are presented for sulfide adsorbates on Cu(100) in HCl solution. Sulfides 177-184 sulfotransferase family 1A member 3 Homo sapiens 154-157 15741159-8 2005 (v) cis-Parinaric acid bound to HNF-4alpha with intact F-domain was readily displaceable by S-hexadecyl-CoA, a nonhydrolyzable thioether analogue of LCFA-CoAs. Sulfides 127-136 hepatocyte nuclear factor 4 alpha Homo sapiens 32-42 16382042-4 2005 Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells. Sulfides 55-62 catenin beta 1 Homo sapiens 149-161 16382042-4 2005 Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells. Sulfides 55-62 caspase 3 Homo sapiens 180-193 16382042-4 2005 Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells. Sulfides 55-62 cyclin D1 Homo sapiens 201-210 16022542-6 2005 X-ray crystallographic and NMR analyses indicated that MECYS(-), PRCYS(-), and MET(-) were bound in fac-Re(CO)(3)AA complexes as tridentate monoanionic ligands through amino, thioether, and alpha-carboxyl groups. Sulfides 175-184 FA complementation group C Homo sapiens 100-103 15934732-1 2005 The reaction of fac-[NEt(4)](2)[Re(CO)(3)Br(3)] with (S)-(2-(2"-pyridyl)ethyl)cysteamine, L(1), in methanol leads to the formation of the cationic fac-[Re(CO)(3)(NSN)][Br] complex, 1, with coordination of the nitrogen of the pyridine, the sulfur of the thioether, and the nitrogen of the primary amine. Sulfides 253-262 FA complementation group C Homo sapiens 16-19 15859580-6 2005 The thioether bond modification was confirmed in the Fab fragment of a monoclonal antibody by LC-MS and nonreduced Lys-C peptide mapping with tandem mass spectrometry. Sulfides 4-13 FA complementation group B Homo sapiens 53-56 16388676-2 2006 [reaction: see text] Diphenyl diselenide (and disulfide) undergo facile reaction with indium(I) iodide and the corresponding intermediate complex condenses in situ with a variety of substituted vinyl bromides in the presence of a catalytic amount of tetrakis(triphenylphosphine)palladium(0) [Pd(PPh3)4] in THF at room temperature to produce vinylic selenides and sulfides in good yields. Sulfides 363-371 caveolin 1 Homo sapiens 295-299 16229464-5 2005 Mass spectral analysis demonstrates that irreversible inactivation of DDAH occurs through selective formation of a covalent thioether bond with the active-site Cys249 residue. Sulfides 124-133 dimethylarginine dimethylaminohydrolase 1 Homo sapiens 70-74 15780627-2 2005 A SAR study revealed that the acylhydrazide thioether side-chain and the thiophene ring were critical to inhibitory activity. Sulfides 44-53 sarcosine dehydrogenase Homo sapiens 2-5 15871241-2 2005 The molar ratio of the reduced CrVI to the oxidized S(-II) was 1:1.5 during the reaction, suggesting that the product of sulfide oxidation was elemental sulfur. Sulfides 121-128 transcription elongation factor A1 Homo sapiens 52-57 15685583-1 2005 Three-dimensional, orthogonal lead sulfide (PbS) nanowire arrays and networks have been prepared by using a simple, atmospheric pressure chemical vapor deposition (APCVD) method. Sulfides 35-42 cholinergic receptor muscarinic 3 Homo sapiens 44-47 15698789-3 2005 Structure-activity relationship studies on these compounds revealed that only sulfides with (Z)-configuration have potential COX-2 inhibitory activity. Sulfides 78-86 mitochondrially encoded cytochrome c oxidase II Homo sapiens 125-130 15645036-1 2005 A new series of Ru2(DMBA)4(oligo(phenyleneethyne))2 compounds bearing sulfide termini was synthesized; structural characterization revealed both the rigid rod nature and extended pi-conjugation in these metallaynes; in the presence of these metallaynes, Au nanoparticles readily assembled into dimers and chains with well-defined inter-dimer distances. Sulfides 70-77 doublecortin domain containing 2 Homo sapiens 16-19 15728339-2 2005 Cys formation is catalyzed by the enzyme O-acetylserine(thiol)lyase (OASTL) using O-acetylserine (OAS) and sulfide as substrates. Sulfides 107-114 cysteine synthase Solanum tuberosum 41-67 15728339-2 2005 Cys formation is catalyzed by the enzyme O-acetylserine(thiol)lyase (OASTL) using O-acetylserine (OAS) and sulfide as substrates. Sulfides 107-114 cysteine synthase Solanum tuberosum 69-74 15859264-6 2005 In all cases, the binding ability of Ni-S-R is intermediate between that of a free thiolate and a free thioether. Sulfides 103-112 solute carrier family 5 member 5 Homo sapiens 37-41 15610027-6 2004 The pyridine hemochromagen redox difference spectrum for heme x covalently bound to the cytochrome b polypeptide isolated from SDS-PAGE displays a low-amplitude broad spectrum with a peak at 553 nm, similar to that of other hemes with a single thioether linkage. Sulfides 244-253 cytochrome b Chlamydomonas reinhardtii 88-100 15519575-1 2004 Activated phenylalanine 4-monooxygenase, phenylalanine hydroxylase (PAH), is known to be involved in the S-oxidation of a number of sulfide compounds. Sulfides 132-139 phenylalanine hydroxylase Rattus norvegicus 41-66 18969720-12 2004 The multisyringe flow method was successfully applied to the determination of sulfide in different spiked water matrices (namely, mineral, tap, freshwater, seawater and wastewater) with recoveries ranging from 96 to 104%. Sulfides 78-85 nuclear RNA export factor 1 Homo sapiens 139-142 15519575-1 2004 Activated phenylalanine 4-monooxygenase, phenylalanine hydroxylase (PAH), is known to be involved in the S-oxidation of a number of sulfide compounds. Sulfides 132-139 phenylalanine hydroxylase Rattus norvegicus 68-71 15555934-2 2004 Hemoglobin I (HbI) from Lucina pectinata is a monomeric protein composed of 143 amino acids with high sulfide affinity. Sulfides 102-109 FKBP prolyl isomerase 4 Rattus norvegicus 14-17 15476669-7 2004 The 2-phenylethyl moiety resulted in higher A(3)AR affinity (K(i) in nM) when linked to the 2-position of adenosine through an ether group (54), than when linked through an amine (310) or thioether (1960). Sulfides 188-197 adenosine A3 receptor Homo sapiens 44-50 15544340-5 2004 SoxF catalyzed sulfide-dependent horse heart cytochrome c reduction at the optimum pH of 6.0 with a k(cat) of 3.9 s(-1), a K(m) of 2.3 microM for sulfide, and a K(m) of 116 microM for cytochrome c, as determined by nonlinear regression analysis. Sulfides 15-22 cytochrome c, somatic Equus caballus 45-57 15544340-5 2004 SoxF catalyzed sulfide-dependent horse heart cytochrome c reduction at the optimum pH of 6.0 with a k(cat) of 3.9 s(-1), a K(m) of 2.3 microM for sulfide, and a K(m) of 116 microM for cytochrome c, as determined by nonlinear regression analysis. Sulfides 15-22 cytochrome c, somatic Equus caballus 184-196 15544340-5 2004 SoxF catalyzed sulfide-dependent horse heart cytochrome c reduction at the optimum pH of 6.0 with a k(cat) of 3.9 s(-1), a K(m) of 2.3 microM for sulfide, and a K(m) of 116 microM for cytochrome c, as determined by nonlinear regression analysis. Sulfides 146-153 cytochrome c, somatic Equus caballus 45-57 15544340-5 2004 SoxF catalyzed sulfide-dependent horse heart cytochrome c reduction at the optimum pH of 6.0 with a k(cat) of 3.9 s(-1), a K(m) of 2.3 microM for sulfide, and a K(m) of 116 microM for cytochrome c, as determined by nonlinear regression analysis. Sulfides 146-153 cytochrome c, somatic Equus caballus 184-196 15544340-6 2004 The yield of 1.9 mol of cytochrome c reduced per mole of sulfide suggests sulfur or polysulfide as the product. Sulfides 57-64 cytochrome c, somatic Equus caballus 24-36 15169827-0 2004 Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells. Sulfides 0-9 solute carrier family 6 member 4 Homo sapiens 107-128 15229170-2 2004 M25 is a methyl sulfide metabolite generated from MK-0767 following CYP3A4-mediated TZD ring opening and subsequent methylation of the sulfide intermediate M22. Sulfides 16-23 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 68-74 15229170-2 2004 M25 is a methyl sulfide metabolite generated from MK-0767 following CYP3A4-mediated TZD ring opening and subsequent methylation of the sulfide intermediate M22. Sulfides 135-142 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 68-74 18969639-2 2004 Total mercury ranging from 0.17 to 33mugL(-1) in 15mL of sample solutions containing up to 200mgL(-1) of sulfide can be determined without any serious interference by sulfide when 1mL of the sodium hypochlorite solution was added after dilution of the sample solution to 25mL. Sulfides 105-112 LLGL scribble cell polarity complex component 1 Homo sapiens 94-100 15450491-1 2004 S-Ribosylhomocysteinase (LuxS) cleaves the thioether bond in S-ribosylhomocysteine to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione. Sulfides 43-52 Lutheran suppressor, X-linked Homo sapiens 25-29 15169827-0 2004 Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells. Sulfides 0-9 solute carrier family 6 member 4 Homo sapiens 130-135 15169827-0 2004 Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells. Sulfides 0-9 solute carrier family 6 member 4 Homo sapiens 196-201 14769043-2 2004 The two thioether bonds linking protein to heme in cyt c are present in 1, and the native axial ligand His-18 remains coordinated to iron. Sulfides 8-17 cytochrome c, somatic Equus caballus 51-56 15294458-6 2004 We have here demonstrated that the thioether-containing organophosphate insecticides, phorate and disulfoton, are substrates for expressed human FMO2.1 with Km of 57 and 32 microM, respectively. Sulfides 35-44 flavin containing dimethylaniline monoxygenase 2 Homo sapiens 145-149 15287744-1 2004 S-ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of type II bacterial quorum sensing molecule. Sulfides 61-70 Lutheran suppressor, X-linked Homo sapiens 25-29 15049842-0 2004 Thioether side chain cyclization for helical peptide formation: inhibitors of estrogen receptor-coactivator interactions. Sulfides 0-9 estrogen receptor 1 Homo sapiens 78-95 15207590-5 2004 The AgI gel trapped sulfide through the formation of Ag2S. Sulfides 20-27 angiotensin II receptor type 1 Homo sapiens 53-57 15198611-9 2004 DFT calculations on putative thioether-coordinated intermediates reveal that the Co(II)- and Zn(II)-thioethers exhibit weaker M-S bonding than Ni(II). Sulfides 29-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-87 15070323-1 2004 The Rh(II)-catalyzed imination of sulfoxides and sulfides using [Rh(2)(OAc)(4)] as a catalyst and trifluoroacetamide or sulfonylamides in combination with iodobenzene diacetate and magnesium oxide affords sulfoximines and sulfilimines, respectively, in a stereospecific manner. Sulfides 49-57 Rh blood group D antigen Homo sapiens 4-10 14556904-1 2003 Two cyclic peptides with a thioether bond have been synthesised corresponding to the 9-22 (9LKMADPNRFRGKDL(22)) sequence of glycoprotein D (gD-1) of Herpes simplex virus. Sulfides 27-36 atypical chemokine receptor 1 (Duffy blood group) Homo sapiens 124-138 15197303-4 2004 5,5"-dithiobis (2-nitrobenzoic acid) (DTNB) acts to regenerate disulfide bonds between the two Fabs, whereas o-phenylenedimaleimide (o-PDM) acts to form a thioether bond between the two Fabs. Sulfides 155-164 dystrobrevin beta Homo sapiens 38-42 14651971-6 2003 Only MsrA and a membrane associated Msr can reduce sulindac to the active sulfide. Sulfides 74-81 methionine sulfoxide reductase A Bos taurus 5-9 14651971-6 2003 Only MsrA and a membrane associated Msr can reduce sulindac to the active sulfide. Sulfides 74-81 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Bos taurus 5-8 15058468-3 2004 By means of the overall mass-transfer coefficient (KLa), the transfer coefficient of hydrogen sulfide (KLa(H2S)), referring to total sulfide, was correlated to that of oxygen (KLa(O2)) (i.e., the reaeration coefficient). Sulfides 94-101 immunoglobulin kappa variable 1D-39 Homo sapiens 176-182 14624563-2 2003 Incorporation of soft thioether donors into an aniline-derived ligand framework that can be linked to a fluorescein platform affords sensor MS1, which shows a approximately 5-fold increase in integrated emission upon addition of 1 equiv of Hg(II). Sulfides 22-31 MS Homo sapiens 140-143 14611171-5 2003 High biological activity is observed for the sulfide, sulfoxide, sulfone, and desulfinyl derivatives in both the ethiprole and the fipronil series in GABA receptor assays (human recombinant beta3 homomer and house fly head membranes) with [(3)H]EBOB and in topical toxicity to house flies with and without the P450-inhibiting synergist piperonyl butoxide. Sulfides 45-52 GABA type A receptor-associated protein Homo sapiens 150-163 14583032-1 2003 S-Ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether linkage of S-ribosylhomocysteine (SRH) to produce l-homocysteine and 4,5-dihydroxy-2,3-pentanedione (DHPD). Sulfides 61-70 Lutheran suppressor, X-linked Homo sapiens 25-29 14521914-6 2003 Oxidation of the thioether linkage into sulfoxide facilitated the binding to Grb2-SH2 markedly. Sulfides 17-26 growth factor receptor bound protein 2 Homo sapiens 77-81 14641596-9 2003 Pore water and rock geochemical analyses suggest that these SRB"s may have been sustained by sulphate diffusing from the adjacent U-rich, Carbon Leader where it was formed by radiolysis of sulphide. Sulfides 189-197 chaperonin containing TCP1 subunit 4 Homo sapiens 60-63 12927853-1 2003 Following our earlier work on a phage library derived non-phosphorylated thioether-cyclized peptide inhibitor of Grb2 SH2 domain, a series of small peptide analogues with various cyclization linkage or various ring size were designed and synthesized and evaluated to investigate the optimal conformational constraint for this novel Grb2-SH2 blocker. Sulfides 73-82 growth factor receptor bound protein 2 Homo sapiens 113-117 18969180-2 2003 The NiO layer was found to produce a stripping-like signal to sulphide and gave a linear peak current response from 20 to 90 muM. Sulfides 62-70 latexin Homo sapiens 125-128 18969180-3 2003 The response was further enhanced by repetitive cycling allowing accumulation of nickel sulphide at the electrode surface such that lower micromolar levels of sulphide (i.e. 5 muM) can be determined. Sulfides 88-96 latexin Homo sapiens 176-179 12953206-7 2003 Similar results were obtained in the case of the reaction of the cyclohexenyl carbonate rac-1 a and of the acyclic carbonates rac-3 aa and rac-3 ba with 2-pyridinethiol and lead to the formation of the sulfides 5 ab, 6 ab, and 6 bb, respectively. Sulfides 202-210 Rac family small GTPase 1 Homo sapiens 88-93 12953206-7 2003 Similar results were obtained in the case of the reaction of the cyclohexenyl carbonate rac-1 a and of the acyclic carbonates rac-3 aa and rac-3 ba with 2-pyridinethiol and lead to the formation of the sulfides 5 ab, 6 ab, and 6 bb, respectively. Sulfides 202-210 Rac family small GTPase 3 Homo sapiens 126-131 12953206-7 2003 Similar results were obtained in the case of the reaction of the cyclohexenyl carbonate rac-1 a and of the acyclic carbonates rac-3 aa and rac-3 ba with 2-pyridinethiol and lead to the formation of the sulfides 5 ab, 6 ab, and 6 bb, respectively. Sulfides 202-210 Rac family small GTPase 3 Homo sapiens 139-144 12667062-1 2003 Protein farnesyl transferase (PFTase) catalyzes the reaction between farnesyl diphosphate and a protein substrate to form a thioether-linked prenylated protein. Sulfides 124-133 protein farnesyltransferase Saccharomyces cerevisiae S288C 0-28 14719256-4 2003 This means that sulfur containing in coal and plastic tends to formed gaseous sulfides, such as H2S, COS, CS2, etc. Sulfides 78-86 chorionic somatomammotropin hormone 2 Homo sapiens 106-109 12832624-4 2003 In many eubacteria, the oxidation of sulfide involves the enzyme sulfide:quinone oxidoreductase (SQR). Sulfides 37-44 crystallin zeta Homo sapiens 73-95 12705835-1 2003 S-Ribosylhomocysteinase (LuxS) catalyzes the cleavage of the thioether linkage of S-ribosylhomocysteine (SRH) to produce L-homocysteine and 4,5-dihydroxy-2,3-pentanedione (DHPD). Sulfides 61-70 Lutheran suppressor, X-linked Homo sapiens 25-29 19719610-1 2003 Abstract Black reduced sediment surfaces (Black Spots) in sandy intertidal flats of the German Wadden Sea (southern North Sea) are characterised by elevated sulphide concentrations (up to 20 mM) and low redox potentials. Sulfides 157-165 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 122-125 12739977-3 2003 At C-3, side chains L-CH(2)- and L-CH(2)CH(2)- (L = thioether or phosphine) ensured formation of chelates to a cis-dichloropalladium(II) fragment through side-chain atom L and the pyrazole nitrogen closest to the side chain. Sulfides 52-61 complement C3 Homo sapiens 3-6 12667062-1 2003 Protein farnesyl transferase (PFTase) catalyzes the reaction between farnesyl diphosphate and a protein substrate to form a thioether-linked prenylated protein. Sulfides 124-133 protein farnesyltransferase Saccharomyces cerevisiae S288C 30-36 17219914-4 2003 An elevated level of urinary thioether (mercapturic acid derivatives) a significant elevation in the level of DNA SSB was found among exposed workers in comparison with control group (p < 0.01). Sulfides 29-38 small RNA binding exonuclease protection factor La Homo sapiens 114-117 12636281-2 2003 The in situ profiler accumulates sulfide from the sediment interstitial water through a diffusive gel onto a AgI binding gel to form black Ag2S. Sulfides 33-40 angiotensin II receptor type 1 Homo sapiens 139-143 12666791-6 2003 The response of the photo-sensors is linear with respect to inflowing sulphide concentration, while the most rapid response to dissolved sulphide occurs at a flow rate of approximately 200 ml min(-1) (equivalent to a hydraulic loading rate of 21 cm min(-1). Sulfides 137-145 CD59 molecule (CD59 blood group) Homo sapiens 192-198 12666791-10 2003 At the optimal flow rate for the successful use of the cartridge as a sulphide warning system (200 ml min(-1)), required substrate masses for the complete removal of dissolved sulphide (over the experimental range of 0-1000 microM) are relatively small (0.5-2 kg). Sulfides 70-78 CD59 molecule (CD59 blood group) Homo sapiens 102-108 12666791-10 2003 At the optimal flow rate for the successful use of the cartridge as a sulphide warning system (200 ml min(-1)), required substrate masses for the complete removal of dissolved sulphide (over the experimental range of 0-1000 microM) are relatively small (0.5-2 kg). Sulfides 176-184 CD59 molecule (CD59 blood group) Homo sapiens 102-108 16233527-1 2003 A porous wool keratin sponge was used for immobilization of lysozyme, a model bioactive substance and was demonstrated to be a unique biomaterial in terms that the activity of lysozyme linked to the sponge through disulfide bond was gradually released, while lysozyme through thioether bond was stably maintained. Sulfides 276-285 lysozyme Homo sapiens 176-184 12538647-7 2003 Whereas in the soluble proteins the thiol group from cysteine (R-SH) and the thioether group from methionine (R-S-CH(3)) are the most abundant forms, in the TTR fibrils there is a significant oxidation of sulfur to the sulfonate form in the cysteine residue and a partial oxidation of sulfur to sulfoxide in the methionine residues. Sulfides 77-86 transthyretin Homo sapiens 157-160 12611518-3 2003 It was found that the natural HgS crystals had activity higher than those of synthesized ones but lower than those of other sulfides of transition metals, e.g., CdS and ZnS, belonging to the same II-IV chalcogenides. Sulfides 124-132 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 30-33 12556160-0 2003 Mild and highly chemoselective oxidation of thioethers mediated by Sc(OTf)3. Sulfides 44-54 POU class 5 homeobox 1 Homo sapiens 67-75 12814324-4 2003 The initial confusion was presented by the fact that not all drugs used to select for resistance were substrates for thioether bond catalysis by GSTs. Sulfides 117-126 glutathione S-transferase kappa 1 Homo sapiens 145-149 16233527-1 2003 A porous wool keratin sponge was used for immobilization of lysozyme, a model bioactive substance and was demonstrated to be a unique biomaterial in terms that the activity of lysozyme linked to the sponge through disulfide bond was gradually released, while lysozyme through thioether bond was stably maintained. Sulfides 276-285 lysozyme Homo sapiens 60-68 16233527-1 2003 A porous wool keratin sponge was used for immobilization of lysozyme, a model bioactive substance and was demonstrated to be a unique biomaterial in terms that the activity of lysozyme linked to the sponge through disulfide bond was gradually released, while lysozyme through thioether bond was stably maintained. Sulfides 276-285 lysozyme Homo sapiens 176-184 12906301-1 2003 The effects of O2 and NO3- concentrations on in situ sulfate reduction and sulfide reoxidation in microaerophilic wastewater biofilms grown on rotating disk reactors were investigated by the use of microelectrodes for O2, S2-, NO3-, NO2-, and pH. Sulfides 75-82 NBL1, DAN family BMP antagonist Homo sapiens 22-25 12906301-8 2003 On the basis of the present results, it was estimated that of all sulfide produced, 13% of the sulfide was precipitated by metal ions as FeS and S0 just above the sulfate reduction zone, 65% was anaerobically oxidized to SO4(2-) with NO3- as an electron acceptor and 22% was aerobically oxidized within the biofilm incubated in 70 micromol l(-1) of DO and 280 micromol l(-1) of NO3-. Sulfides 66-73 NBL1, DAN family BMP antagonist Homo sapiens 234-237 12906301-8 2003 On the basis of the present results, it was estimated that of all sulfide produced, 13% of the sulfide was precipitated by metal ions as FeS and S0 just above the sulfate reduction zone, 65% was anaerobically oxidized to SO4(2-) with NO3- as an electron acceptor and 22% was aerobically oxidized within the biofilm incubated in 70 micromol l(-1) of DO and 280 micromol l(-1) of NO3-. Sulfides 66-73 NBL1, DAN family BMP antagonist Homo sapiens 378-381 12906301-8 2003 On the basis of the present results, it was estimated that of all sulfide produced, 13% of the sulfide was precipitated by metal ions as FeS and S0 just above the sulfate reduction zone, 65% was anaerobically oxidized to SO4(2-) with NO3- as an electron acceptor and 22% was aerobically oxidized within the biofilm incubated in 70 micromol l(-1) of DO and 280 micromol l(-1) of NO3-. Sulfides 95-102 NBL1, DAN family BMP antagonist Homo sapiens 234-237 12906301-8 2003 On the basis of the present results, it was estimated that of all sulfide produced, 13% of the sulfide was precipitated by metal ions as FeS and S0 just above the sulfate reduction zone, 65% was anaerobically oxidized to SO4(2-) with NO3- as an electron acceptor and 22% was aerobically oxidized within the biofilm incubated in 70 micromol l(-1) of DO and 280 micromol l(-1) of NO3-. Sulfides 95-102 NBL1, DAN family BMP antagonist Homo sapiens 378-381 12182617-0 2002 A cassette ligation strategy with thioether replacement of three Gly-Gly peptide bonds: total chemical synthesis of the 101 residue protein early pregnancy factor [psi(CH(2)S)28-29,56-57,76-77]. Sulfides 34-43 heat shock protein family E (Hsp10) member 1 Homo sapiens 140-162 12459024-7 2002 (3) At the C-7 position, aminopyrrolidine derivatives are more effective than other amines or thioether derivatives. Sulfides 94-103 complement C7 Homo sapiens 11-14 12676192-2 2002 Three sulphide agents showed dose-dependent antioxidative protection against glucose-induced erythrocyte membrane oxidation (p<.05), and these agents at 10 microM significantly increased the retention of alpha-tocopherol in erythrocyte membrane (p<.05), in which DAT was the most effective agent (p<.05). Sulfides 6-14 solute carrier family 6 member 3 Homo sapiens 269-272 12676192-4 2002 The anti-aggregative activity of each sulphide agent was dose dependent (p<.05), in which DAT showed the greatest inhibitory effect on platelet aggregation than DADS, followed by DAS (p<.05). Sulfides 38-46 solute carrier family 6 member 3 Homo sapiens 93-96 12676192-5 2002 After ADP stimulation, the malondialdehyde (MDA) formation in platelets treated with sulphide agents was significantly less (p<.05), in which DADS and DAT showed similar antioxidative activities (p>.05). Sulfides 85-93 solute carrier family 6 member 3 Homo sapiens 154-157 12537375-0 2002 Renewable-surface sol-gel derived carbon ceramic electrode fabricated by [Ru(bpy)(tpy)Cl]PF6 and its application as an amperometric sensor for sulfide and sulfur oxoanions. Sulfides 143-150 sperm associated antigen 17 Homo sapiens 89-92 12151402-1 2002 In in vitro experiments, prenylcysteine lyase (Pcly) cleaves the thioether bond of prenylcysteines to yield free cysteine and the aldehyde of the isoprenoid lipid. Sulfides 65-74 prenylcysteine oxidase 1 Mus musculus 25-45 12151402-1 2002 In in vitro experiments, prenylcysteine lyase (Pcly) cleaves the thioether bond of prenylcysteines to yield free cysteine and the aldehyde of the isoprenoid lipid. Sulfides 65-74 prenylcysteine oxidase 1 Mus musculus 47-51 12182617-1 2002 The 101 residue protein "early pregnancy factor" (EPF), also known as human chaperonin 10, was synthesized from four functionalized, but unprotected, peptide segments by a sequential thioether ligation strategy. Sulfides 183-192 heat shock protein family E (Hsp10) member 1 Homo sapiens 25-47 12182617-1 2002 The 101 residue protein "early pregnancy factor" (EPF), also known as human chaperonin 10, was synthesized from four functionalized, but unprotected, peptide segments by a sequential thioether ligation strategy. Sulfides 183-192 heat shock protein family E (Hsp10) member 1 Homo sapiens 50-53 12182617-7 2002 These findings were used to formulate a sequential thioether ligation strategy for the synthesis of EPF, a 101 amino acid protein containing three Gly-Gly sites approximately equidistantly spaced within the peptide chain. Sulfides 51-60 heat shock protein family E (Hsp10) member 1 Homo sapiens 100-103 11948457-6 2002 Both sulfide and sulfone metabolites of sulindac, which differ in the ability to cause COX-2 inhibition, induced a significant dose- and time-dependent cell growth reduction accompanied by increase in apoptosis without concomitant cell cycle arrest. Sulfides 5-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 87-92 12161060-7 2002 (3) All sulphide analogs show higher AR binding affinity and more potent functional activity than their corresponding sulphone analogs, with the exception of ligand R-8. Sulfides 8-16 androgen receptor Homo sapiens 37-39 12056913-1 2002 The yeast iso-1-cytochrome c variant Cys14Ser has been prepared in which one of the two thioether bonds by which the heme prosthetic group is normally bound to the protein has been eliminated. Sulfides 88-97 threonine ammonia-lyase ILV1 Saccharomyces cerevisiae S288C 10-15 11689077-3 2001 The sulfides were designed to act as BFA prodrugs via the metabolic oxidation to the sulfoxide and subsequent syn elimination. Sulfides 4-12 synemin Homo sapiens 110-113 11993874-4 2002 Interaction of As(III) and As(V) with the sulfide surfaces shows primary coordination to four oxygens (As-O: 1.69-1.76 A) with further sulfur (approximately 3.1 A) and iron (3.4-3.5 A) shells suggesting outer sphere complexation. Sulfides 42-49 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 27-32 11896689-8 2002 In this helical C-terminus of betaAP, the peptide bond C=O group C-terminal of Ile(31) is located very close to the Met(35) sulfur and could stabilize a Met(35) sulfide radical cation through formation of an (S-O) three-electron bond. Sulfides 161-168 amyloid beta precursor protein Homo sapiens 30-36 11782142-5 2002 As the maleimide group can react with the sulfhydryl group to form a stable thioether moiety, these complexes have been used as thiol-specific luminescent labels for a thiolated oligonucleotide, glutathione, and bovine serum albumin and human serum albumin. Sulfides 76-85 albumin Homo sapiens 219-232 11782142-5 2002 As the maleimide group can react with the sulfhydryl group to form a stable thioether moiety, these complexes have been used as thiol-specific luminescent labels for a thiolated oligonucleotide, glutathione, and bovine serum albumin and human serum albumin. Sulfides 76-85 albumin Homo sapiens 243-256 12073655-4 2002 In addition, we focus on a modification of haem for cytochrome c biogenesis, a complex process that entails both transport between cellular compartments and a specific thioether linkage between the haem moiety and the apoprotein. Sulfides 168-177 cytochrome c, somatic Homo sapiens 52-64 11763065-2 2001 The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion. Sulfides 236-243 mitochondrially encoded cytochrome c oxidase II Homo sapiens 86-92 11687614-2 2001 We have used a flexible thioether linker as a loop mimetic in the human yes kinase-associated protein (YAP 65) WW domain, a three-stranded, 44-residue, beta-sheet protein. Sulfides 24-33 Yes1 associated transcriptional regulator Homo sapiens 103-109 11763065-2 2001 The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion. Sulfides 236-243 mitochondrially encoded cytochrome c oxidase II Homo sapiens 363-369 11763065-3 2001 The catalyst itself is a Co(II) complex with the sulfide ion produced by the decomposition of the analyte during the deposition step. Sulfides 49-56 mitochondrially encoded cytochrome c oxidase II Homo sapiens 25-31 11559087-2 2001 For benzyl alcohol and the sulfides, the rate law for the formation of the Os(V)-hydrazido complex, trans-[Os(V)(tpy)(Cl)2(NN(CH2)4O)](+), is first order in both trans-[Os(VI)(tpy)(Cl)2(NN(CH2)4O)](2+) and reductant, with k(benzyl) (25.0 +/- 0.1 degrees C, CH3CN) = (1.80 +/- 0.07) x 10(-4) M(-1) s(-1), k(SEt2) = (1.33 +/- 0.02) x 10(-1) M(-1) s(-1), and k(SPh2) = (1.12 +/- 0.05) x 10(-1) M(-1) s(-1). Sulfides 27-35 SET domain containing 2, histone lysine methyltransferase Homo sapiens 306-310 11559087-2 2001 For benzyl alcohol and the sulfides, the rate law for the formation of the Os(V)-hydrazido complex, trans-[Os(V)(tpy)(Cl)2(NN(CH2)4O)](+), is first order in both trans-[Os(VI)(tpy)(Cl)2(NN(CH2)4O)](2+) and reductant, with k(benzyl) (25.0 +/- 0.1 degrees C, CH3CN) = (1.80 +/- 0.07) x 10(-4) M(-1) s(-1), k(SEt2) = (1.33 +/- 0.02) x 10(-1) M(-1) s(-1), and k(SPh2) = (1.12 +/- 0.05) x 10(-1) M(-1) s(-1). Sulfides 27-35 ankyrin 1 Homo sapiens 358-362 11334888-1 2001 The substitution of alanines for the two cysteines which form thioether linkages to the haem group in cytochrome c(552) from Hydogenobacter thermophilus destabilises the native protein fold. Sulfides 62-71 cytochrome c, somatic Homo sapiens 102-114 11325259-2 2001 N-Allyl glycosides of various oligosaccharides were photochemically coupled with cysteamine to yield amino-terminated thioether spacers, which were accepted by transglutaminase to transamidate the side-chain gamma-carboxamide group in the dipeptide Z-Gln-Gly. Sulfides 118-127 transglutaminase 1 Homo sapiens 160-176 11535067-12 2001 The product of the AKR1A1-catalyzed oxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene was trapped with 2-mercaptoethanol and characterized as a thioether conjugate of benzo[a]pyrene-7,8-dione by LC/MS. Sulfides 159-168 aldo-keto reductase family 1 member A1 Homo sapiens 19-25 11527740-1 2001 The synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Sulfides 110-119 complement C5 Homo sapiens 130-133 11453733-7 2001 Inhibition of endothelial cell gamma-GT at the blood-brain barrier likely enhances the uptake into brain of thioether metabolites of MDA and MDMA, such as 5-(glutathion-S-yl)-alpha-MeDA and 2,5-bis-(glutathion-S-yl)-alpha-MeDA, by increasing the pool of thioether conjugates available for uptake via the intact GSH transporter. Sulfides 108-117 gamma-glutamyltransferase 1 Rattus norvegicus 31-39 11453733-7 2001 Inhibition of endothelial cell gamma-GT at the blood-brain barrier likely enhances the uptake into brain of thioether metabolites of MDA and MDMA, such as 5-(glutathion-S-yl)-alpha-MeDA and 2,5-bis-(glutathion-S-yl)-alpha-MeDA, by increasing the pool of thioether conjugates available for uptake via the intact GSH transporter. Sulfides 254-263 gamma-glutamyltransferase 1 Rattus norvegicus 31-39 11343803-6 2001 Although not as efficient as reduced flavins, sulfide displayed kinetic parameters which suggest a potential physiological role for the chalcogenide in converting the iron storage protein into apoferritin. Sulfides 46-53 ferritin heavy chain 1 Homo sapiens 193-204 11343803-7 2001 To further probe the relevance of sulfide in the mobilization of iron, several enzymes, such as NifS, rhodanese, or sulfite reductase generating reduced forms of sulfur by different mechanisms, have been assayed for their ability to catalyze the release of iron from ferritin. Sulfides 34-41 NFS1 cysteine desulfurase Homo sapiens 96-100 11462985-5 2001 Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages. Sulfides 171-180 protein kinase C zeta Homo sapiens 51-72 11245463-5 2001 Both the sulfide and sulfone metabolites of sulindac as well as more potent cyclic GMP-dependent phosphodiesterase inhibitors were shown to cause inhibition of extracellular signal-regulated kinase (ERK)1/2 phosphorylation at doses (40-600 microM) and times (1-5 days) consistent with the induction of apoptosis by the drugs. Sulfides 9-16 mitogen-activated protein kinase 1 Homo sapiens 160-206 11462985-5 2001 Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages. Sulfides 171-180 protein kinase C zeta Homo sapiens 74-82 11462985-5 2001 Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages. Sulfides 171-180 peptidylglycine alpha-amidating monooxygenase Homo sapiens 140-143 11237266-5 2001 The stoichiometry of the major species formed in the palladium(II)-GlyGlyMet system is [PdH(-2) L]- and this is coordinated by the amino, two-amide and the thioether donor functions. Sulfides 156-165 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 88-91 11078725-7 2001 These surprising findings indicate that prenylcysteine lyase utilizes a novel oxidative mechanism to cleave thioether bonds and provide insight into the unique role this enzyme plays in the cellular metabolism of prenylcysteines. Sulfides 108-117 prenylcysteine oxidase 1 Homo sapiens 40-60 11132619-0 2000 A new thioether-ligated iron porphyrin as a model of a protonated form of P450 active site. Sulfides 6-15 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 74-78 15954561-4 2001 Here, we report the results of batch and column experiments which demonstrate the feasibility to stimulate the endogenous SRB- population, resulting in the in situ precipitation of HMM as sulfide complexes. Sulfides 188-195 chaperonin containing TCP1 subunit 4 Homo sapiens 122-125 11124415-15 2001 Mucin partly inhibited the discoloration from sulfide. Sulfides 46-53 LOC100508689 Homo sapiens 0-5 11123951-10 2000 NifS is a cysteine desulfurase, releasing sulfur or sulfide (depending on the reducing environment) from L-cysteine, in agreement with its proposed role as a sulfur donor to Fe-S clusters. Sulfides 52-59 NFS1 cysteine desulfurase Homo sapiens 0-4 11101476-9 2000 Sulfide formation in fecal batch cultures supplemented with both bovine serum albumin and casein correlated with protein digestion, as measured by the disappearance of Lowry-reactive substances and the appearance of ammonia. Sulfides 0-7 albumin Homo sapiens 72-85 11132619-1 2000 Thioether-ligated iron porphyrin (complex 1) was synthesized as a model of the protonated form of P450 to explore the possible involvement of the protonated form in the catalytic cycle, and ether-ligated iron porphyrin (complex 2) was also synthesized for comparison. Sulfides 0-9 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 98-102 10816041-8 2000 Reduction of cytochrome b was stimulated by 2-n-nonyl-4-hydroxyquinoline-N-oxide in the presence of excess sulfide under oxic conditions. Sulfides 107-114 petB Aquifex aeolicus VF5 13-25 11010904-5 2000 The assimilatory sulfate reduction pathway was redirected to overproduce cysteine, and excess cysteine was converted to sulfide by cysteine desulfhydrase. Sulfides 120-127 cystathionine gamma-lyase Homo sapiens 131-153 11010904-7 2000 To maximize sulfide production and cadmium precipitation, the production of cysteine desulfhydrase was modulated to achieve an optimal balance between the production and degradation of cysteine. Sulfides 12-19 cystathionine gamma-lyase Homo sapiens 76-98 10950857-8 2000 The marked expression levels of FMO1 found in human kidney coupled to the high catalytic activity of this isoform toward a diverse array of sulfides and tertiary amines suggest the possibility that human renal FMO1 is a significant contributor to the metabolic clearance of drugs and other xenobiotics bearing these functionalities. Sulfides 140-148 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 32-36 10950857-8 2000 The marked expression levels of FMO1 found in human kidney coupled to the high catalytic activity of this isoform toward a diverse array of sulfides and tertiary amines suggest the possibility that human renal FMO1 is a significant contributor to the metabolic clearance of drugs and other xenobiotics bearing these functionalities. Sulfides 140-148 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 210-214 10891064-2 2000 The homodimeric IscS protein has been shown to be a cysteine desulfurase that catalyzes the reductive conversion of cysteine to alanine and sulfide. Sulfides 140-147 NFS1 cysteine desulfurase Homo sapiens 16-20 11196947-3 2000 In the complex ions of the equilibrium [CuI(mmb)2](+) + ClO4- reversible e- + [CuII(mmb)2-(eta 1-ClO4)]+ the almost linear N-Cu-N backbone is invariant whereas the bonds to the thioether sulfur centers and especially the changing S-Cu-S angle (145.18(5) degrees for the CuII species, 109.33(3) degrees for the CuI form) reflect the metal oxidation state. Sulfides 177-186 secreted phosphoprotein 1 Homo sapiens 91-96 11093699-2 2000 Uronic acid-based mimetics in which an aliphatic ether (O-glycoside), a thioether (S-glycoside), or acetamide takes the place of the natural C-6 glycerol sidechain of the sialic acid were synthesized from the key intermediate, methyl 2,3,4-tri-O-acetyl-alpha-D-glucopyranosyluronate bromide. Sulfides 72-81 complement C6 Homo sapiens 141-144 11196780-5 2000 The thioether complex (C18H36F6O6RuS8, a = 8.658(3) A, b = 11.533(3) A, c = 8.659(2) A, alpha = 108.33(2) degrees, beta = 91.53(3) degrees, gamma = 106.01(2) degrees, triclinic, P1, Z = 1) is isostructural with its selenoether analogue, involving two facially coordinated trithioether ligands in the syn configuration. Sulfides 4-13 crystallin gamma F, pseudogene Homo sapiens 178-187 10816041-9 2000 This "oxidant-induced reduction" of cytochrome b suggests that electron transport from sulfide to oxygen in A. aeolicus employs the cytochrome bc complex via the quinone pool. Sulfides 87-94 petB Aquifex aeolicus VF5 36-48 10625461-1 1999 The heme prosthetic group of cytochrome c is covalently attached to the protein through thioether bonds to two cysteine side chains. Sulfides 88-97 cytochrome c, somatic Homo sapiens 29-41 10579851-4 1999 Substituents such as thioethers, sulfonamides, and ethers showed improved potency against TACE when compared with Marimastat. Sulfides 21-31 ADAM metallopeptidase domain 17 Homo sapiens 90-94 10474204-4 1999 The activity of glutamic-pyruvic transaminase (GPT) in serum was shown to increase significantly on the treatment of Wistar rats with sulfide produced through hydrolytic degradation of TTM and DTM, the latter being more easily degraded. Sulfides 134-141 glutamic--pyruvic transaminase Rattus norvegicus 16-45 10579818-5 1999 In particular, the sulfide 4a and the sulfone 5a were potent, broad-spectrum inhibitors of the MMPs with IC(50)"s against MMP-1 of 0.8 and 1.9 nM, respectively. Sulfides 19-26 matrix metallopeptidase 1 Homo sapiens 95-99 10579818-5 1999 In particular, the sulfide 4a and the sulfone 5a were potent, broad-spectrum inhibitors of the MMPs with IC(50)"s against MMP-1 of 0.8 and 1.9 nM, respectively. Sulfides 19-26 matrix metallopeptidase 1 Homo sapiens 122-127 10388716-4 1999 Sulfate was shown to be the end product of sulfide oxidation and was observed at a rate of 2 to 3 nmol min-1 mg of protein-1. Sulfides 44-51 CD59 molecule (CD59 blood group) Homo sapiens 104-109 11207750-7 1999 Strain CKB can also couple chlorate reduction to the oxidation of ferrous iron, sulphide, or the reduced form of the humic substances analogue 2,6-anthrahydroquinone disulphonate. Sulfides 80-88 creatine kinase B Homo sapiens 7-10 10822550-1 1999 [formula: see text] In the presence of catalytic quantites of Cu(OTf)2 the novel hydroxamic acid anhydride salt functions competently in the trifluoroacetamidation of sulfides to afford N-(trifluoroacetyl)sulfilimines. Sulfides 167-175 POU class 2 homeobox 2 Homo sapiens 62-70 10474204-4 1999 The activity of glutamic-pyruvic transaminase (GPT) in serum was shown to increase significantly on the treatment of Wistar rats with sulfide produced through hydrolytic degradation of TTM and DTM, the latter being more easily degraded. Sulfides 134-141 glutamic--pyruvic transaminase Rattus norvegicus 47-50 11670973-10 1999 The formal potentials show that the Co(III) oxidation state is stabilized by the six thiolate bridging ligands in comparison to six thioether donor atoms, whereas capping has a destabilizing effect. Sulfides 132-141 mitochondrially encoded cytochrome c oxidase III Homo sapiens 36-42 21662756-2 1999 Sulfide species from the sampled waters diffuse through a polyacrylamide hydrogel and then react with pale yellow AgI((s)), incorporated at the surface of a second gel, to form black Ag(2)S((s)). Sulfides 0-7 angiotensin II receptor type 1 Homo sapiens 183-189 9558333-9 1998 A sulfide bridge is formed between C-11 and C-14, which interrupts the conjugation. Sulfides 2-9 anti-Mullerian hormone receptor type 2 Rattus norvegicus 44-48 10400328-1 1999 For the study of biological phenomena influenced by the R- and N-Ras proteins, characteristic peptides which embody the correct lipid modifications of their parent proteins (palmitoyl thioesters, geranylgeranyl thioethers, and farnesyl thioethers), as well as analogues thereof, may serve as efficient tools. Sulfides 211-221 NRAS proto-oncogene, GTPase Homo sapiens 63-68 10400348-13 1999 This is linked to reversal of the thioether protection step and generation of the base for substrate deprotonation at C-3. Sulfides 34-43 complement C3 Homo sapiens 118-121 10096294-3 1999 Coupling of Cys89 of RNase and Cys87 of EDN to proteins at these sites via a thioether bond produced enzymatically active conjugates that were resistant to RI. Sulfides 77-86 ribonuclease A family member 2 Homo sapiens 40-43 10096294-5 1999 The transferrin-rhRNase(Gly89-->Cys) thioether conjugate was 5000-fold more toxic to U251 cells than recombinant wild-type hRNase. Sulfides 40-49 transferrin Homo sapiens 4-15 9822550-8 1998 Sulfides were more potent and selective COX-2 inhibitors than the corresponding sulfoxides or sulfones or other heteroatom-containing compounds. Sulfides 0-8 prostaglandin-endoperoxide synthase 2 Mus musculus 40-45 9822550-13 1998 The efficacy of the sulfides in inhibiting COX-2 activity in inflammatory cells, our recent results on the selectivity of 70 in attenuating growth of COX-2-expressing colon cancer cells, and its selectivity for inhibition of COX-2 over COX-1 in vivo indicate that this novel class of covalent modifiers may serve as potential therapeutic agents in inflammatory and proliferative disorders. Sulfides 20-28 prostaglandin-endoperoxide synthase 2 Mus musculus 43-48 9873503-1 1998 To enhance PTP binding interactions, both inside and outside the pTyr binding pocket, a thioether-cyclized peptide has been designed based on the EGF receptor autophosphorylation sequence (EGFR988-993) "Asp-Ala-Asp-Glu-pTyr-Leu", in which the pTyr resiude has been replaced by the nonphosphorus-containing pTyr mimetic fluoro-O-malonyltyrosine (FOMT, 2). Sulfides 88-97 protein tyrosine phosphatase receptor type U Homo sapiens 11-14 9873503-1 1998 To enhance PTP binding interactions, both inside and outside the pTyr binding pocket, a thioether-cyclized peptide has been designed based on the EGF receptor autophosphorylation sequence (EGFR988-993) "Asp-Ala-Asp-Glu-pTyr-Leu", in which the pTyr resiude has been replaced by the nonphosphorus-containing pTyr mimetic fluoro-O-malonyltyrosine (FOMT, 2). Sulfides 88-97 epidermal growth factor receptor Homo sapiens 189-193 18967489-2 1999 During the cathodic scan, the last one is reduced to a transient Co(0) species that catalyses the reduction of hydrogen ion to the hydrogen molecule by a mechanism alike to that emphasized for the Co(II)-sulfide ion system (F.G. Banica, N. Spataru, T. Spataru, Electroanalysis 9 (1997) 1341). Sulfides 204-211 mitochondrially encoded cytochrome c oxidase II Homo sapiens 197-202 9878421-3 1999 Cytochrome c is distinguished by having its heme attached by a dedicated heme lyase through thioether links to cysteine side-chains, and the apoprotein shows no evidence of preorganization under physiological conditions. Sulfides 92-101 cytochrome c, somatic Homo sapiens 0-12 9878421-4 1999 Nevertheless, addition of heme to two short fragments of cytochrome c enhances helical structure substantially (from approximately 8% to approximately 22%), an effect that depends on iron ligation but not thioether linkage. Sulfides 205-214 cytochrome c, somatic Homo sapiens 57-69 9742209-8 1998 Chloride ion effects on the MPO-catalysed oxygenation of sulphides were also studied. Sulfides 57-66 myeloperoxidase Homo sapiens 28-31 9742209-11 1998 In the presence of 100 mM chloride the catalytic efficiency (kcat/Km) of MPO increased 3-4-fold, whatever the sulphide considered, but racemic products were obtained. Sulfides 110-118 myeloperoxidase Homo sapiens 73-76 9712781-2 1998 Aiming at targeted delivery of liposomal immunogens, we have previously reported the conjugation via a thioether bond of the GM1 ganglioside-binding subunit of cholera toxin (CTB) to the liposomal outer surface. Sulfides 103-112 coenzyme Q10A Mus musculus 125-128 9712781-2 1998 Aiming at targeted delivery of liposomal immunogens, we have previously reported the conjugation via a thioether bond of the GM1 ganglioside-binding subunit of cholera toxin (CTB) to the liposomal outer surface. Sulfides 103-112 phosphate cytidylyltransferase 1, choline, beta isoform Mus musculus 175-178 9613590-1 1998 Extracts of the alkaliphilic sulfur-oxidizing autotroph strain AL3 contained sulfide:cytochrome c oxidoreductase. Sulfides 77-84 cytochrome c, somatic Equus caballus 85-97 9613590-3 1998 Although up to 60% of the initial activity was lost during Triton X-100 extraction, further purification resulted in an enzyme that catalyzed sulfide oxidation with horse heart cytochrome c. Sulfides 142-149 cytochrome c, somatic Equus caballus 177-189 9483484-5 1997 In the CA2 sub field a decrease of sulphide-silver staining was noticeable in aged rats in comparison with younger cohorts. Sulfides 35-43 carbonic anhydrase 2 Rattus norvegicus 7-10 9483484-6 1997 A progressive reduction in the intensity of sulphide-silver staining was observed in the CA3 sub field of the hippocampus. Sulfides 44-52 carbonic anhydrase 3 Rattus norvegicus 89-92 9287348-3 1997 We have identified and characterized a novel enzyme, which we term prenylcysteine lyase, that is capable of cleaving the thioether bond of prenylcysteines. Sulfides 121-130 prenylcysteine oxidase 1 Homo sapiens 67-87 9099686-4 1997 An approximate 2500-fold purification of the converter activity yielded a monomeric, 43-kDa, pyridoxal phosphate-containing enzyme, which catalyzed the breakdown of L-cysteine to yield sulfide (assembled in ferredoxin), pyruvate, and ammonia; 1 mol of [2Fe-2S] ferredoxin was formed per 2 mol of cysteine utilized. Sulfides 185-192 period circadian regulator 2 Homo sapiens 283-288 9248866-0 1997 Sulfide influence on polymorphonuclear functions: a possible role for Ca2+ involvement. Sulfides 0-7 carbonic anhydrase 2 Homo sapiens 70-73 9248866-5 1997 These data were in agreement with the sulfide inhibition of cytosolic free Ca2+ concentration [Ca2+]i increase normally induced by ionomycin. Sulfides 38-45 carbonic anhydrase 2 Homo sapiens 75-78 9248866-5 1997 These data were in agreement with the sulfide inhibition of cytosolic free Ca2+ concentration [Ca2+]i increase normally induced by ionomycin. Sulfides 38-45 carbonic anhydrase 2 Homo sapiens 95-98 11669934-0 1997 Sequential Growth of Heteropolymetallic (Pt(2) --> AgPt(2) --> Ag(2)Pt(2) --> Ag(2)Pt(4)) Sulfide Aggregates. Sulfides 99-106 angiopoietin 2 Homo sapiens 54-61 9309585-6 1997 Conjugation of the forward peptides through a C-terminal thioether and the reverse peptides through an N-terminal thioether to polysucrose abolished the adhesive activity of the peptides and enhanced their antiproliferative activities for endothelial and breast carcinoma cells stimulated by fibroblast growth factor-2. Sulfides 114-123 fibroblast growth factor 2 Mus musculus 292-318 9511458-6 1997 Substitution of chlorine at C-6 for an amine or thioether function was effected in the reactions with hydrazine, amines, and thiophenols. Sulfides 48-57 complement C6 Homo sapiens 28-31 9016341-5 1997 However, a strain that produced 6-fold more sulfide than wild-type cells was found to be 6-fold more resistant to DDP and twice as resistant to Cd; an association between DDP resistance and sulfide production was observed in three other strains that were examined, and overproduction of sulfide was accompanied by reduced platination of DNA. Sulfides 44-51 translocase of inner mitochondrial membrane 8A Homo sapiens 114-117 18966791-2 1997 CdS-Ag(2)S mixtures were obtained by gas/solid-phase reaction between silver-cadmium mixed powder and hydrogen sulphide gas (dry method) and by ionic reaction between cadmium-silver mixed ions and sulphide ion (wet method). Sulfides 111-119 angiotensin II receptor type 1 Homo sapiens 4-10 18966791-4 1997 As the best way, CdS-Ag(2)S mixture was obtained by adding sulphide ion solution to 5 mol% cadmium ion and 95 mol% silver ion mixed solution while measuring silver sulphide (Ag(2)S) electrode potential as an indicator electrode. Sulfides 59-67 angiotensin II receptor type 1 Homo sapiens 21-27 9167276-4 1997 NCS was covalently coupled to transferrin using the heterobifunctional reagent sulfo-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) and 2-iminothiolane to give a stable thioether-linked conjugate with a ratio of 1.6 mol of NCS per mole of transferrin. Sulfides 176-185 transferrin Homo sapiens 30-41 9381987-5 1997 Conjugate was prepared by derivatizing the enzyme and monoclonal antibody KS1/4 with linkers containing maleimide and sulfhydryl groups, respectively; interaction of these groups to form a stable thioether bond joined the proteins. Sulfides 196-205 epithelial cell adhesion molecule Homo sapiens 74-79 9016341-5 1997 However, a strain that produced 6-fold more sulfide than wild-type cells was found to be 6-fold more resistant to DDP and twice as resistant to Cd; an association between DDP resistance and sulfide production was observed in three other strains that were examined, and overproduction of sulfide was accompanied by reduced platination of DNA. Sulfides 44-51 translocase of inner mitochondrial membrane 8A Homo sapiens 171-174 9016341-5 1997 However, a strain that produced 6-fold more sulfide than wild-type cells was found to be 6-fold more resistant to DDP and twice as resistant to Cd; an association between DDP resistance and sulfide production was observed in three other strains that were examined, and overproduction of sulfide was accompanied by reduced platination of DNA. Sulfides 190-197 translocase of inner mitochondrial membrane 8A Homo sapiens 171-174 9016341-5 1997 However, a strain that produced 6-fold more sulfide than wild-type cells was found to be 6-fold more resistant to DDP and twice as resistant to Cd; an association between DDP resistance and sulfide production was observed in three other strains that were examined, and overproduction of sulfide was accompanied by reduced platination of DNA. Sulfides 190-197 translocase of inner mitochondrial membrane 8A Homo sapiens 171-174 9016341-6 1997 These results indicate that GSH and the GSH-derived phytochelatin peptides do not play critical roles in determining sensitivity to DDP in S. pombe but rather identify increased production of sulfide as a possible new mechanism of DDP resistance that may also be relevant to human cells. Sulfides 192-199 translocase of inner mitochondrial membrane 8A Homo sapiens 231-234 8775977-5 1996 The nis, spa, epi and pep clusters contain lanB and lanC genes that are presumed to code for two types of enzymes that have been implicated in the modification reactions characteristic of all lantibiotics, i.e. dehydration and thio-ether ring formation. Sulfides 227-237 surfactant protein A2 Homo sapiens 9-12 8987848-4 1996 We expected that inactivation of MET2 would lead to accumulation of sulfide and derepression of the entire sulfur assimilation pathway and, therefore, possibly also to sulfite accumulation. Sulfides 68-75 homoserine O-acetyltransferase Saccharomyces cerevisiae S288C 33-37 8943000-2 1996 Multiple copies of [Nle-4,D-Phe-7]-alpha-MSH, a potent analog of alpha-MSH, were conjugated to microspheres (latex beads) or macrospheres (polyamide beads) through a thioether or disulfide bond. Sulfides 166-175 proopiomelanocortin Homo sapiens 35-44 8897095-6 1996 Conversion of L-7 to L-1 was accomplished in a one-pot sequence consisting of three steps: hydrolysis of the thiolacetate, formation of the thioether and hydrolysis of the methyl ester. Sulfides 140-149 neuropeptide B Homo sapiens 14-17 8897095-6 1996 Conversion of L-7 to L-1 was accomplished in a one-pot sequence consisting of three steps: hydrolysis of the thiolacetate, formation of the thioether and hydrolysis of the methyl ester. Sulfides 140-149 L1 cell adhesion molecule Homo sapiens 21-24 8692725-4 1996 Monoclonal IgG3 NI32/2 antibodies directed against a polyoma virus tumor-associated antigen expressed on A9 ctc 102 murine fibrosarcoma cells were attached to the D-SSL HPE via a thioether bond to form the D-SSIL-32/2. Sulfides 179-188 Immunoglobulin heavy constant gamma 3 Mus musculus 11-15 11666965-3 1996 Opposite asymmetric induction was achieved only when sulfides containing exo- (3 and 4) and endo- (6 and 7) alkylthio groups were used. Sulfides 53-61 synaptotagmin like 2 Homo sapiens 73-106 8946095-3 1996 However, AgF also stains teeth black due to sulfide precipitation and thus is unacceptable for permanent teeth. Sulfides 44-51 angiopoietin like 6 Homo sapiens 9-12 8869738-4 1996 Substrates for MRP include thioether-linked conjugates of lipophilic compounds with glutathione, cysteinyl glycine, cysteine, and N-acetyl cysteine, but also glutathione disulfide, and glucuronate conjugates such as etoposide glucuronide. Sulfides 27-36 ATP binding cassette subfamily C member 1 Homo sapiens 15-18 9346826-3 1996 We prepared a thioether linked Rev34-50-cellulose conjugate to affinity purify a fragment of synthetic mRNA corresponding to the high affinity binding site for Rev. Sulfides 14-23 Rev Human immunodeficiency virus 1 31-34 7547927-1 1995 The small GTP-binding protein G25K and the protein K-Ras 4B contain prenyl groups (geranylgeranyl and farnesyl, respectively) that are thioether linked to a C-terminal cysteine which is methylated on its alpha-carboxyl group. Sulfides 135-144 cell division cycle 42 Homo sapiens 30-34 7547927-1 1995 The small GTP-binding protein G25K and the protein K-Ras 4B contain prenyl groups (geranylgeranyl and farnesyl, respectively) that are thioether linked to a C-terminal cysteine which is methylated on its alpha-carboxyl group. Sulfides 135-144 KRAS proto-oncogene, GTPase Homo sapiens 51-59 7665899-5 1995 Conjugation was done by means of a thioether bond using succinimidyl(4-N-maleimidomethyl)cyclohexane-1-carboxylate to modify the dipalmitoylphosphatidyl-ethanolamine constituent of liposomes and N-succinimidyl-3-(2-pyridyldithio)propionate to thiolate CT or CTB. Sulfides 35-44 chitobiase Homo sapiens 258-261 7779759-3 1995 The new thioether derivatives were tested to assess their relative binding affinity for the estrogen receptor and their estrogenic or antiestrogenic activity in the ZR-75-1 (ER+) cell line. Sulfides 8-17 estrogen receptor 1 Homo sapiens 92-109 8617401-7 1995 We propose to name the trout protein sulphide linked SAP (SL-SAP). Sulfides 37-45 amyloid P component, serum Homo sapiens 53-56 8617401-7 1995 We propose to name the trout protein sulphide linked SAP (SL-SAP). Sulfides 37-45 amyloid P component, serum Homo sapiens 61-64 7663158-10 1995 These results suggest that native human ASGPR consists of sulfide- and non-sulfide-linked heterotrimers and -dimers from H1 and H2 subunits with a functional restriction to their glycosylation states. Sulfides 58-65 asialoglycoprotein receptor 1 Homo sapiens 40-45 7663158-10 1995 These results suggest that native human ASGPR consists of sulfide- and non-sulfide-linked heterotrimers and -dimers from H1 and H2 subunits with a functional restriction to their glycosylation states. Sulfides 75-82 asialoglycoprotein receptor 1 Homo sapiens 40-45 7861176-6 1995 These results suggest that cysteines i the DAT second extracellular loop may provide sulfide residues crucial to full transporter expression, at least in part, through interference with membrane insertion. Sulfides 85-92 solute carrier family 6 member 3 Homo sapiens 43-46 8539785-4 1995 The sulfide 4a was a very weak inhibitor of glucose-6-phosphate dehydrogenase, whereas the sulfone 4c did not inhibit the enzyme. Sulfides 4-11 glucose-6-phosphate dehydrogenase Homo sapiens 44-77 7524688-0 1994 Site-specific religation of G-CSF fragments through a thioether bond. Sulfides 54-63 colony stimulating factor 3 Homo sapiens 28-33 7532086-10 1994 These results suggest that our MoAb 80G is a suitable carrier for targeting AFP-producing hepatoma cells, and that the noncleavable thioether conjugate is promising as an AFP-producing hepatoma-targeted drug delivery system. Sulfides 132-141 alpha fetoprotein Homo sapiens 171-174 8168094-1 1994 In order to develop a new chemotherapeutic agent based on exploitation of the specific metabolic pathway of malignant melanoma, a phenolic thioether, N-acetyl-4-S-cysteaminylphenol (NA-CAP), the substrate of melanin-forming enzyme, tyrosinase was developed. Sulfides 139-148 tyrosinase Mus musculus 232-242 8203918-10 1994 Active aconitase could be reconstituted from the purified IRE-BP obtained from the expression system by addition of iron, thiol, and sulfide, and the characteristic epr spectrum of the 3Fe form of cytosolic aconitase was obtained after ferricyanide oxidation of the reconstituted material. Sulfides 133-140 aconitase 1 Homo sapiens 58-64 8305515-3 1993 The synthesis of mAb-SEA conjugates which were prepared by introducing thiol groups on SEA and iodoacetyl or maleimide groups on mAb forming a stable thioether linkage between SEA and mAb is described. Sulfides 150-159 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 21-24 7688570-12 1993 These results suggest that EGF can react with the reactive thiol ester of proteinase-activated alpha 2M by nucleophilic attack of the alpha-amino group and to a lesser extent by sulfide-disulfide exchange with the free SH of the cleaved thiol ester. Sulfides 178-185 endogenous retrovirus group K member 18 Homo sapiens 74-84 8117918-3 1993 The cDNA-expressed FMO3 was used to investigate the regio- and stereoselective N- and S-oxygenation of a number of tertiary amines and sulfides, respectively. Sulfides 135-143 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 19-23 8230103-0 1993 The interaction of ammonium, sulfonium, and sulfide analogues of metoclopramide with the dopamine D2 receptor. Sulfides 44-51 dopamine receptor D2 Mus musculus 89-109 7688570-12 1993 These results suggest that EGF can react with the reactive thiol ester of proteinase-activated alpha 2M by nucleophilic attack of the alpha-amino group and to a lesser extent by sulfide-disulfide exchange with the free SH of the cleaved thiol ester. Sulfides 178-185 alpha-2-macroglobulin Homo sapiens 95-103 8343527-2 1993 The interaction of the compounds having a 3-alkylthioether side chain (compounds 1 and 2) with HLE was found to involve rapid acylation of the enzyme, followed by total regain of enzymatic activity within 3 h. Interestingly, compounds 3-8, having an oxidized thioether side chain, were found to be highly effective, time-dependent, irreversible inhibitors of the enzyme. Sulfides 49-58 elastase, neutrophil expressed Homo sapiens 95-98 8380814-4 1993 Protection against myeloperoxidase and H2O2 was also observed with the thioether-containing antibiotics, ticarcillin and ceftazidime, but at higher concentrations than with the aminoglycosides. Sulfides 71-80 myeloperoxidase Homo sapiens 19-34 8343527-4 1993 These findings demonstrate that, unlike the physiological inhibitor of HLE (alpha-1-proteinase inhibitor), which is inactivated upon oxidation, low-molecular-weight compounds retain and/or show enhanced inhibitory activity towards HLE upon oxidation of the thioether side chain and lay the groundwork for the development of compounds that embody proteinase inhibitory and antioxidant activity. Sulfides 257-266 elastase, neutrophil expressed Homo sapiens 71-74 8343527-4 1993 These findings demonstrate that, unlike the physiological inhibitor of HLE (alpha-1-proteinase inhibitor), which is inactivated upon oxidation, low-molecular-weight compounds retain and/or show enhanced inhibitory activity towards HLE upon oxidation of the thioether side chain and lay the groundwork for the development of compounds that embody proteinase inhibitory and antioxidant activity. Sulfides 257-266 elastase, neutrophil expressed Homo sapiens 231-234 8325834-1 1993 Low molecular mass GTP-binding proteins encoded by the Rab gene family are posttranslationally modified by a specific geranylgeranyltransferase (GGTase II), which catalyzes the thioether linkage of geranylgeranyl isoprenoids to cysteines within one of the following carboxyl-terminal sequence motifs: GGCC, CXC, CCSN. Sulfides 177-186 RAB1B, member RAS oncogene family Homo sapiens 55-58 8496926-6 1993 The fluorodeoxyuridine-HSA conjugates were then further linked via a stable thioether bond to the mouse monoclonal antibody 791T/36. Sulfides 76-85 albumin Homo sapiens 23-26 8464740-2 1993 The sulfide dimer TsT was stable to degradation by snake-venom phosphodiesterase, calf spleen phosphodiesterase, Nuclease P1 and Nuclease S1. Sulfides 4-11 thiosulfate sulfurtransferase Bos taurus 18-21 8433013-5 1993 These phenolic thioethers (PTEs) and phenolic thioether amine (amides) (PTEAs), which are substrates of tyrosinase, showed significant cytotoxicity that is selective to melanocytes and melanoma cells. Sulfides 15-25 tyrosinase Homo sapiens 104-114 8398344-3 1993 Disulphide- and thioether-linked GA-17-NCS were nearly equipotent immunoconjugates, but thioether-linked GA-17-NCS was more effective than disulphide-linked conjugates with 250 U/kg NCS content on day 50 (P < 0.05). Sulfides 16-25 eukaryotic translation initiation factor 3 subunit M Homo sapiens 33-38 8398344-3 1993 Disulphide- and thioether-linked GA-17-NCS were nearly equipotent immunoconjugates, but thioether-linked GA-17-NCS was more effective than disulphide-linked conjugates with 250 U/kg NCS content on day 50 (P < 0.05). Sulfides 88-97 eukaryotic translation initiation factor 3 subunit M Homo sapiens 105-110 8398344-4 1993 Thioether-linked GA-17-NCS was significantly more effective on day 50 than free NCS with 500 U/kg or 250 U/kg NCS content (P < 0.05, P < 0.01, respectively). Sulfides 0-9 eukaryotic translation initiation factor 3 subunit M Homo sapiens 17-22 1396551-2 1992 We have identified a cadmium sensitive S. pombe mutant deficient in the accumulation of a sulfide-containing phytochelatin-cadmium complex, and have isolated the gene, designated hmt1, that complements this mutant. Sulfides 90-97 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase Homo sapiens 179-183 1489581-1 1992 A peptide containing amino acid residues 41-84 of the CD4 molecule was synthesized and coupled through a thioether bond to human serum albumin. Sulfides 105-114 CD4 molecule Homo sapiens 54-57 1489581-1 1992 A peptide containing amino acid residues 41-84 of the CD4 molecule was synthesized and coupled through a thioether bond to human serum albumin. Sulfides 105-114 albumin Homo sapiens 129-142 1520585-5 1992 MAb 323/A3 and GUS were linked through a stable thioether bond. Sulfides 48-57 glucuronidase beta Homo sapiens 15-18 1597855-4 1992 Cyclization was accomplished by reaction of the N-terminal bromoacetyl group with the cysteine sulfhydryl at pH 8 at high dilution, resulting in thioether-bridged cyclic peptides [cyclo-S-Ac-(AA1)-RGD-Cys-OH]. Sulfides 145-154 AA1 Homo sapiens 192-195 2175152-6 1990 The metabolism of catecholestrogens may be divided into reversible and irreversible reactions, of which the reaction with the catechol-O-methyltransferase, and thereby the interaction with catecholamines, the conjugation, and the thioether formation are the most prominent. Sulfides 230-239 catechol-O-methyltransferase Homo sapiens 126-154 1352119-2 1992 This study aimed to assess occupational exposure to MOCA using as indices: (1) the post-work urinary output of MOCA; (2) urinary thioethers, assuming that conjugation with glutathione might be a significant pathway for the elimination of putative electrophilic metabolites of MOCA; and (3) sister-chromatid exchange (SCE) frequency in peripheral lymphocytes as an indicator of genetic damage. Sulfides 129-139 dedicator of cytokinesis 3 Homo sapiens 52-56 1547530-7 1992 The elution position of thioether conjugates was identified by their insensitivity to hydrolysis with beta-glucuronidase and arylsulfatase and by synthesis of thioether conjugates in V79 (XEM-2) cells, which express cytochrome P450IA1 and have relatively high levels of glutathione S-transferases but low levels of UDP-glucuronyltransferases and sulfotransferases. Sulfides 24-33 beta-glucuronidase Cricetulus griseus 102-120 1819745-1 1991 A novel stereospecific synthesis of antitumor active thioether analogs of platelet-activating factor (PAF) is reported. Sulfides 53-62 PCNA clamp associated factor Homo sapiens 74-100 1819745-1 1991 A novel stereospecific synthesis of antitumor active thioether analogs of platelet-activating factor (PAF) is reported. Sulfides 53-62 PCNA clamp associated factor Homo sapiens 102-105 2051494-2 1991 EC and PEC can be coupled to the cysteine moiety of glutathione spontaneously or by the glutathione S-transferase system (GST), giving nontoxic metabolites that can be eliminated as urinary thioethers (UT). Sulfides 190-200 glutathione S-transferase kappa 1 Homo sapiens 88-113 1850747-3 1991 Herein, we demonstrate that terminal cysteine residues in the rab1B, rab2, and rab5 proteins undergo thioether modification by isoprenyl groups when these proteins are translated in vitro in the presence of a radiolabeled isoprenoid precursor, [3H]mevalonate. Sulfides 101-110 RAB1B, member RAS oncogene family Homo sapiens 62-67 1850747-3 1991 Herein, we demonstrate that terminal cysteine residues in the rab1B, rab2, and rab5 proteins undergo thioether modification by isoprenyl groups when these proteins are translated in vitro in the presence of a radiolabeled isoprenoid precursor, [3H]mevalonate. Sulfides 101-110 RAB2A, member RAS oncogene family Homo sapiens 69-73 1850747-3 1991 Herein, we demonstrate that terminal cysteine residues in the rab1B, rab2, and rab5 proteins undergo thioether modification by isoprenyl groups when these proteins are translated in vitro in the presence of a radiolabeled isoprenoid precursor, [3H]mevalonate. Sulfides 101-110 RAB5A, member RAS oncogene family Homo sapiens 79-83 1563770-1 1992 Synthetic oligosaccharides derived from the capsular polysaccharide (PRP) of Haemophilus influenzae type b were conjugated to carrier proteins via a thioether linkage. Sulfides 149-158 prion protein Mus musculus 69-72 1549603-9 1992 Sulforaphane and its sulfide and sulfone analogues induced both quinone reductase and glutathione transferase activities in several mouse tissues. Sulfides 21-28 crystallin, zeta Mus musculus 64-81 1787075-3 1991 The reactive sulfide groups are provided by first reducing a small fraction of the disulfide bridges in the antibody protein or by starting with Fab" fragments, which already have reactive sulfide groups. Sulfides 13-20 FA complementation group B Homo sapiens 145-148 2376587-7 1990 Quantitation of DCIP reduction by MPT of Mo fragment of sulfite oxidase showed a two-electron oxidation of MPT, even when the Mo fragment was denatured in the presence of Hg2+ to prevent internal reduction reactions due to sulfhydryls or sulfide. Sulfides 238-245 sulfite oxidase Rattus norvegicus 56-71 9994996-0 1990 Spin-filter effect of ferromagnetic europium sulfide tunnel barriers. Sulfides 45-52 spindlin 1 Homo sapiens 0-4 2172221-0 1990 Site-directedly mutated human cytochrome c which retains heme c via only one thioether bond. Sulfides 77-86 cytochrome c, somatic Homo sapiens 30-42 2172221-1 1990 Although Cys-14 (human numbering) of cytochrome c was conserved during its molecular evolution and it is supposed to be essential for most cytochromes c to retain heme c via two thioether bonds, a site-directedly mutated human cytochrome c which has an alanine residue at this position and only one thioether bond through Cys-17 turns out to be functional. Sulfides 178-187 cytochrome c, somatic Homo sapiens 37-49 2172221-1 1990 Although Cys-14 (human numbering) of cytochrome c was conserved during its molecular evolution and it is supposed to be essential for most cytochromes c to retain heme c via two thioether bonds, a site-directedly mutated human cytochrome c which has an alanine residue at this position and only one thioether bond through Cys-17 turns out to be functional. Sulfides 299-308 cytochrome c, somatic Homo sapiens 37-49 2172221-1 1990 Although Cys-14 (human numbering) of cytochrome c was conserved during its molecular evolution and it is supposed to be essential for most cytochromes c to retain heme c via two thioether bonds, a site-directedly mutated human cytochrome c which has an alanine residue at this position and only one thioether bond through Cys-17 turns out to be functional. Sulfides 299-308 cytochrome c, somatic Homo sapiens 227-239 2172221-3 1990 The absorption spectrum of the atypical cytochrome c is red shifted, and similar to those of Euglena and Crithidia cytochromes c, which also have only one thioether bond [Pettigrew, G.W., Leaver, J.L., Meyer, T.E., & Ryle, A.P. Sulfides 155-164 cytochrome c, somatic Homo sapiens 40-52 33774247-6 2021 The arsenic and trace metals released via oxidation of the sulfide phases (particularly Fe sulfides) were almost entirely sequestered by the Fe(III) (oxyhydr)oxides, but acidification during the oxidation stage of the incubation resulted in the pH-dependent release of the As and trace metals (Co, Cu, Ni) (especially in the Fe-rich/organic-low soil). Sulfides 59-66 general transcription factor IIE subunit 1 Homo sapiens 141-148 2381974-3 1990 On the other hand, 10c and 11 were also reacted with alkyl halides to obtain their thioether derivatives, 12a,b and 13. Sulfides 83-92 Rho GTPase activating protein 9 Homo sapiens 19-22 33819812-4 2021 Here, we utilized systemically administered antioxidant thioether core-cross-linked nanoparticles (NP1) that scavenge and inactivate ROS to reduce this secondary spread of injury in a mild controlled cortical impact (CCI) mouse model of TBI. Sulfides 56-65 neuronal pentraxin 1 Mus musculus 99-102 33773263-6 2021 Aryl thioether derivative 7f significantly reduced STAT3 phosphorylation (23%) and its nuclear localisation (16%) at 10 muM in tumorigenic LPCs, implicating the IL-6/JAK/STAT3 axis is central in the mode of action of our derivatives. Sulfides 5-14 signal transducer and activator of transcription 3 Homo sapiens 51-56 33773263-6 2021 Aryl thioether derivative 7f significantly reduced STAT3 phosphorylation (23%) and its nuclear localisation (16%) at 10 muM in tumorigenic LPCs, implicating the IL-6/JAK/STAT3 axis is central in the mode of action of our derivatives. Sulfides 5-14 interleukin 6 Homo sapiens 161-165 33773263-6 2021 Aryl thioether derivative 7f significantly reduced STAT3 phosphorylation (23%) and its nuclear localisation (16%) at 10 muM in tumorigenic LPCs, implicating the IL-6/JAK/STAT3 axis is central in the mode of action of our derivatives. Sulfides 5-14 signal transducer and activator of transcription 3 Homo sapiens 170-175 34563529-5 2022 H16 to promote plant growth, but stimulated the production of extracellular polysaccharides and inorganic labile sulfide, and enhanced biofilm formation, thereby significantly improved the removal efficiency of Cu2+, Zn2+, Cd2+, and Pb2+. Sulfides 113-120 H1.6 linker histone, cluster member Homo sapiens 0-3 24824874-2 2015 To elucidate the roles of sulfide in inflammation, we have investigated its interactions with human myeloperoxidase (MPO), a major contributor to inflammatory oxidative stress. Sulfides 26-33 myeloperoxidase Homo sapiens 100-115 24824874-2 2015 To elucidate the roles of sulfide in inflammation, we have investigated its interactions with human myeloperoxidase (MPO), a major contributor to inflammatory oxidative stress. Sulfides 26-33 myeloperoxidase Homo sapiens 117-120 24824874-5 2015 Sulfide was a potent reversible inhibitor of MPO enzymic activity with an IC50 of 1 microM. Sulfides 0-7 myeloperoxidase Homo sapiens 45-48 24824874-6 2015 In addition, the measured second-order rate constants for the reactions of sulfide with compound I [k = (1.1 +- 0.06) x 10(6) M(-1) s(-1)] and compound II [k = (2.0 +- 0.03) x 10(5) M(-1) s(-1)] suggest that sulfide is a potential substrate for MPO in vivo. Sulfides 75-82 myeloperoxidase Homo sapiens 249-252 24824874-7 2015 CONCLUSION AND IMPLICATIONS: Endogenous levels of sulfide are likely to inhibit the activity of circulating and endothelium-bound MPO. Sulfides 50-57 myeloperoxidase Homo sapiens 130-133 19471443-2 2003 The sulfides used were cadmium sulfide (CdS) and lead sulfide (PbS); both films have excellent infrared transparency and high refractive index contrast. Sulfides 4-12 cholinergic receptor muscarinic 3 Homo sapiens 63-66 34510342-5 2022 TIE showed toxicity due to different combinations of metals, apolar organic compounds, ammonia and sulphides, depending on the contamination source closest to the sampling station. Sulfides 99-108 tyrosine kinase with immunoglobulin like and EGF like domains 1 Homo sapiens 0-3 34844368-5 2022 TMMTSb was readily formed when trimethylantimony (TMSb) reacted with sulfide. Sulfides 69-76 tropomyosin 2 Homo sapiens 50-54 34523465-0 2022 Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms. Sulfides 47-54 submaxillary gland androgen regulated protein 3B Homo sapiens 9-15 34571221-13 2022 Slowly oxidizing sulfide in the subsoil resulted in annual leaching of 147 kg S ha-1, almost ten times that of non-sulfidic soils. Sulfides 17-24 Rho GTPase activating protein 45 Homo sapiens 80-84 34388569-7 2022 These results are superior to those of the counterpart electrode, confirming aggressive promotion of K-ion storage performance of SnS2 anode brought by the cooperation of Ti3C2Tx, and presenting a reliable strategy to improve the electrochemical performance of sulfide anodes. Sulfides 261-268 sodium voltage-gated channel alpha subunit 11 Homo sapiens 130-134 34517635-0 2021 A novel selective detection method for sulfide in food systems based on the GMP-Cu nanozyme with laccase activity. Sulfides 39-46 5'-nucleotidase, cytosolic II Homo sapiens 76-79 34610772-7 2021 Furthermore, CPD5 did not cause vitamin K-attributed ROS generation and was found to be associated with a significant increase in caspase 3 expression, indicating that, of the synthesized thioether VK3 analogs, CPD5 was a more potent inducer of apoptosis than VK3. Sulfides 188-197 caspase 3 Homo sapiens 130-139 34331972-7 2021 In the I/R mitochondria, carbamidomethylated C122/C125 of cytochrome c1 via alkylating complex III with a down regulation of HCCS was exclusively detected, supporting I/R-mediated thioether defect of heme c1. Sulfides 180-189 cytochrome c-1 Rattus norvegicus 58-71 34517635-1 2021 A selective and sensitive colorimetric strategy for sulfide analysis was developed using GMP-Cu nanozymes with a laccase-like activity. Sulfides 52-59 5'-nucleotidase, cytosolic II Homo sapiens 89-92 34517635-2 2021 This research discovered for the first time that sulfide could significantly enhance the catalytic activity of the GMP-Cu nanozymes by about 3.5 folds. Sulfides 49-56 5'-nucleotidase, cytosolic II Homo sapiens 115-118 34216960-6 2021 Data from XPS proved the main adsorption mechanism to be complexation of Cd2+ with sulfides in the BPS. Sulfides 83-91 CD2 molecule Homo sapiens 73-76 34840424-0 2021 Li4.3AlS3.3Cl0.7: A Sulfide-Chloride Lithium Ion Conductor with Highly Disordered Structure and Increased Conductivity. Sulfides 20-27 lipase family member N Homo sapiens 0-3 34832935-1 2021 In the present study we tested, using the microscale thermophoresis technique, a small library of thionocarbamates, thiolocarbamates, sulfide and disulfide as potential lead compounds for SARS-CoV-2 Mpro drug design. Sulfides 134-141 NEWENTRY Severe acute respiratory syndrome-related coronavirus 199-203 34737229-9 2021 Overexpression of cystathione gamma-lyase (CSE), which can also contribute to cellular sulfide/persulfide production, compensated for the loss of CBS activities, and treatment of shCBS xenografts with a CSE inhibitor further blocked tumor growth. Sulfides 87-94 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 18-41 34737229-9 2021 Overexpression of cystathione gamma-lyase (CSE), which can also contribute to cellular sulfide/persulfide production, compensated for the loss of CBS activities, and treatment of shCBS xenografts with a CSE inhibitor further blocked tumor growth. Sulfides 87-94 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 43-46 34672625-0 2021 An Isopolymolybdate-Incorporated Metal-Organic Framework with Sulfite Oxidase-Mimicking Activity for Photocatalytic Oxidation of Sulfides Utilizing In Situ-Generated Singlet Oxygen. Sulfides 129-137 sulfite oxidase Homo sapiens 62-77 34622576-4 2021 Secondly, the optimized NiS2 /NiSe2 heterostructure at the nanoscale of the inside HMCS is formed after the first discharge/charge cycles, which can provide rich heterojunction interfaces/boundaries of sulfide/selenides to offer faster Na+ pathways, decrease the Na+ diffusion barriers, increase electronic conductivity, and limit the dissolution of polysulfides or polyselenides in the electrolyte. Sulfides 202-209 MKKS centrosomal shuttling protein Homo sapiens 83-87 34587736-0 2021 Design, Synthesis, and Herbicidal Activity of Thioether Containing 1,2,4-Triazole Schiff Bases as Transketolase Inhibitors. Sulfides 46-55 Transketolase, chloroplastic Zea mays 98-111 34587736-2 2021 To discover novel TK inhibitors with potency against resistant weeds, 36 thioether compounds containing 1,2,4-triazole Schiff bases were designed and synthesized for herbicidal activity evaluation. Sulfides 73-82 Transketolase, chloroplastic Zea mays 18-20 34546752-0 2021 ZnO-POM Cluster Sub-1 nm Nanosheets as Robust Catalysts for the Oxidation of Thioethers at Room Temperature. Sulfides 77-87 SUB1 regulator of transcription Homo sapiens 16-21 34546752-5 2021 Significantly, theses materials as robust catalysts showed excellent catalytic activity, selectivity, and stability in the oxidation of thioethers at room temperature, which partly can be attributed to the special 2D sub-1 nm nanostructures with large specific areas leading to the full exposure of active sites. Sulfides 136-146 SUB1 regulator of transcription Homo sapiens 217-222 34832930-1 2021 To develop new potent and highly selective MAO-B inhibitors from chalcone-thioethers, eleven chalcones-thioethers were synthesized and their monoamine oxidase (MAO) inhibition, kinetics, reversibility, and cytotoxicity of lead compounds were analyzed. Sulfides 74-84 monoamine oxidase B Mus musculus 43-48 34832930-1 2021 To develop new potent and highly selective MAO-B inhibitors from chalcone-thioethers, eleven chalcones-thioethers were synthesized and their monoamine oxidase (MAO) inhibition, kinetics, reversibility, and cytotoxicity of lead compounds were analyzed. Sulfides 103-113 monoamine oxidase B Mus musculus 43-48 34758301-4 2021 We show that mice lacking the liver- enriched mitochondrial SOP enzyme thiosulfate sulfurtransferase (Tst-/- mice) exhibit high circulating sulfide, increased gluconeogenesis, hypertriglyceridemia, and fatty liver. Sulfides 140-147 thiosulfate sulfurtransferase, mitochondrial Mus musculus 71-100 34758301-4 2021 We show that mice lacking the liver- enriched mitochondrial SOP enzyme thiosulfate sulfurtransferase (Tst-/- mice) exhibit high circulating sulfide, increased gluconeogenesis, hypertriglyceridemia, and fatty liver. Sulfides 140-147 thiosulfate sulfurtransferase, mitochondrial Mus musculus 102-105 34758301-5 2021 Unexpectedly, hepatic sulfide levels are normal in Tst-/- mice because of exaggerated induction of sulfide disposal, with associated suppression of global protein persulfidation and nuclear respiratory factor 2 target protein levels. Sulfides 99-106 thiosulfate sulfurtransferase, mitochondrial Mus musculus 51-54 34758301-7 2021 We reveal a critical role of TST in hepatic metabolism that has implications for sulfide donor strategies in the context of metabolic disease. Sulfides 81-88 thiosulfate sulfurtransferase, mitochondrial Mus musculus 29-32 34669410-1 2021 Methionine (Met) offers a valuable handle to achieve peptide chemical modification owing to its unique thioether functional group. Sulfides 103-112 SAFB like transcription modulator Homo sapiens 12-15 34590480-5 2021 2015, 11, 525-531) reporting a notable example of a TCI with a cyanoacrylamide warhead that forms a covalent thioether linkage to an active-site cysteine (Cys481) of Bruton"s tyrosine kinase (BTK). Sulfides 109-118 transcobalamin 1 Homo sapiens 52-55 34590480-5 2021 2015, 11, 525-531) reporting a notable example of a TCI with a cyanoacrylamide warhead that forms a covalent thioether linkage to an active-site cysteine (Cys481) of Bruton"s tyrosine kinase (BTK). Sulfides 109-118 Bruton tyrosine kinase Homo sapiens 166-190 34590480-5 2021 2015, 11, 525-531) reporting a notable example of a TCI with a cyanoacrylamide warhead that forms a covalent thioether linkage to an active-site cysteine (Cys481) of Bruton"s tyrosine kinase (BTK). Sulfides 109-118 Bruton tyrosine kinase Homo sapiens 192-195 34768766-0 2021 New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. Sulfides 59-68 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 101-105 34768766-0 2021 New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. Sulfides 59-68 tyrosyl-DNA phosphodiesterase 2 Homo sapiens 107-111 34768766-0 2021 New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. Sulfides 59-68 poly(ADP-ribose) polymerase 1 Homo sapiens 116-121 34378910-5 2021 SnS2/FeS2/rGO bimetallic sulfide electrode boasts a capacity of 768.3 mA h g-1 at the current density of 0.1 A g-1, and 541.2 mA h g-1 at the current density of 1 A g-1 in sodium-ion batteries, which is superior to that of either single metal sulfide SnS2 or FeS2. Sulfides 25-32 sodium voltage-gated channel alpha subunit 11 Homo sapiens 0-4 34593420-1 2021 BACKGROUND/AIM: Ethylmalonic encephalopathy 1 protein (ETHE1) plays an important role in sulfide catabolism and polysulfide formation. Sulfides 89-96 ETHE1 persulfide dioxygenase Homo sapiens 16-45 34593420-1 2021 BACKGROUND/AIM: Ethylmalonic encephalopathy 1 protein (ETHE1) plays an important role in sulfide catabolism and polysulfide formation. Sulfides 89-96 ETHE1 persulfide dioxygenase Homo sapiens 55-60 34593420-2 2021 As sulfides and polysulfides have recently been identified as playing important roles in cancer, we hypothesized that ETHE1 expression would be increased in colon cancer. Sulfides 3-11 ETHE1 persulfide dioxygenase Homo sapiens 118-123 34236069-1 2021 Reported herein is a syn-thioallylation of ynamides incorporating a sulfide moiety at the alpha-position and an allyl group at the beta-position of the ynamide. Sulfides 68-75 synemin Homo sapiens 21-24 34433492-6 2021 Interestingly, in vitro fermentation results showed that gga-miR-222a upregulates the expression of these genes, which increased methionine concentrations but decreased H2S production and soluble sulfide concentrations, indicating the potential of host-derived gga-miR-222a to reduce H2S emission in laying hens. Sulfides 196-203 microRNA 222 Gallus gallus 57-69 34433492-6 2021 Interestingly, in vitro fermentation results showed that gga-miR-222a upregulates the expression of these genes, which increased methionine concentrations but decreased H2S production and soluble sulfide concentrations, indicating the potential of host-derived gga-miR-222a to reduce H2S emission in laying hens. Sulfides 196-203 microRNA 222 Gallus gallus 261-273 34121354-0 2021 Asymmetric sulfoxidation of thioether catalyzed by soybean pod shell peroxidase to form enantiopure sulfoxide in water-in-oil microemulsions:kinetic model. Sulfides 28-37 peroxidase Glycine max 69-79 34105020-2 2021 Prochlorosin 2.8 (Pcn2.8) is a class II lanthipeptide that exhibits a non-overlapping thioether ring pattern, for which no biological activity has been reported yet. Sulfides 86-95 potassium voltage-gated channel subfamily A member 4 Homo sapiens 18-22 34218476-4 2021 By adjusting substituted elements and concentrations, the ionic conductivity of Li4- x Sn1- x Mx S4 can reach 2.45 mS cm-1 , which represents the highest value among all reported moist-air-stable and recoverable lithium-ion sulfide SEs reported. Sulfides 224-231 solute carrier family 38 member 3 Homo sapiens 87-90 34105020-4 2021 In the present work, tandem mass spectrometry, using collision-induced dissociation (CID) and electron capture dissociation (ECD), and trapped ion mobility spectrometry-mass spectrometry (TIMS-MS) were used to investigate structural signatures for the non-overlapping thioether ring pattern of Pcn2.8. Sulfides 268-277 potassium voltage-gated channel subfamily A member 4 Homo sapiens 294-298 34132787-0 2021 Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodeling and heart failure. Sulfides 43-50 crystallin zeta Homo sapiens 51-73 34443785-1 2021 The rapid research progress in tin-based binary sulfides (SnxSy = o-SnS, c-SnS, SnS2, and Sn2S3) by the solution process has opened a new path not only for photovoltaics to generate clean energy at ultra-low costs but also for photocatalytic and thermoelectric applications. Sulfides 48-56 sodium voltage-gated channel alpha subunit 11 Homo sapiens 80-84 34198279-5 2021 The PEC sensing mechanism is supposed to the "signal-off" pattern on account of the ultralow solubility product (Ksp) of Ag2S, derived from the precipitation reaction due to the high affinity between sulfide ion and Ag+. Sulfides 200-207 angiotensin II receptor type 1 Homo sapiens 121-125 34137256-7 2021 (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic acid (1) has been experimentally proved to be a selective and time-dependent irreversible inhibitor of nNOS, and three pathways, including sulfide oxidation, oxidative dethiolation, and oxidative demethylation, have been suggested. Sulfides 192-199 nitric oxide synthase 1 Homo sapiens 156-160 34078074-3 2021 In this paper, we report a heterostructured sulfide/phosphide catalyst (Ni3S2-Ni3P/NF) synthesized via one-step thermal treatment of Ni(OH)2/NF, which allows the simultaneous occurrence of phosphorization and sulfuration. Sulfides 44-51 neurofascin Homo sapiens 83-85 34078074-3 2021 In this paper, we report a heterostructured sulfide/phosphide catalyst (Ni3S2-Ni3P/NF) synthesized via one-step thermal treatment of Ni(OH)2/NF, which allows the simultaneous occurrence of phosphorization and sulfuration. Sulfides 44-51 neurofascin Homo sapiens 141-143 35605514-0 2022 An ultrasensitive SPI/PAI ion source based on a high-flux VUV lamp and its applications for the online mass spectrometric detection of sub-pptv sulfur ethers. Sulfides 144-157 chromogranin A Homo sapiens 18-21 35616614-2 2022 We previously showed that white adipose tissue (WAT) levels of 3-mercaptopyruvate sulfurtransferase (MPST), a mitochondrial cysteine-catabolizing enzyme that yields pyruvate and sulfide species, are downregulated in obesity. Sulfides 178-185 mercaptopyruvate sulfurtransferase Mus musculus 63-99 35616614-2 2022 We previously showed that white adipose tissue (WAT) levels of 3-mercaptopyruvate sulfurtransferase (MPST), a mitochondrial cysteine-catabolizing enzyme that yields pyruvate and sulfide species, are downregulated in obesity. Sulfides 178-185 mercaptopyruvate sulfurtransferase Mus musculus 101-105 35274796-5 2022 Furthermore, incorporation of the thioether moiety in the gelator backbone via the amino acid methionine as shown for the tailormade Nap-FMDM peptide provides a useful modulation option reducing the number of additives. Sulfides 34-43 catenin beta like 1 Homo sapiens 133-136 35294095-5 2022 Moreover, C(sp 2 )-halogen bonds remain intact using this protocol, allowing late-stage installation of the sulfide motif in various bioactive scaffolds, while allowing yet further modification through more traditional C-X bond cleavage protocols. Sulfides 108-115 Sp2 transcription factor Homo sapiens 10-16 34163669-0 2021 A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by a de novo crystal structural and spectroscopic study. Sulfides 54-63 N-sulfoglucosamine sulfohydrolase Homo sapiens 35-39 34163669-7 2021 Abolishing the thioether linkage through mutation of Cys317 resulted in catalytically inactive SfmD variants. Sulfides 15-24 N-sulfoglucosamine sulfohydrolase Homo sapiens 95-99 35522528-4 2022 We use an mRNA display of thioether cyclized peptides to identify a series of potent and highly selective macrocyclic inhibitors of the MAGE-A4:RAD18 interaction. Sulfides 26-35 MAGE family member A4 Homo sapiens 136-143 35522528-4 2022 We use an mRNA display of thioether cyclized peptides to identify a series of potent and highly selective macrocyclic inhibitors of the MAGE-A4:RAD18 interaction. Sulfides 26-35 RAD18 E3 ubiquitin protein ligase Homo sapiens 144-149 35192885-2 2022 Portman Bay (NW Mediterranean Sea), where an estimated amount of 60 Mt of mine tailings from sulphide ores were dumped from 1957 to 1990, is one of the most metal-polluted marine areas in Europe and worldwide. Sulfides 93-101 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 30-33 35312361-2 2022 This framework, however, neglects inheritance from oxidative weathering of pre-existing S-MIF-bearing sedimentary sulfide minerals (i.e., crustal memory), which has recently been invoked to explain apparent discrepancies within the sulfur isotope record. Sulfides 114-121 macrophage migration inhibitory factor Homo sapiens 90-93 35065174-11 2022 Single-well injection tests with WBC-2 and lactate showed that the onset of RDX degradation coincided with the onset of sulfide production, which was affected by the initial perchlorate concentration. Sulfides 120-127 radixin Homo sapiens 76-79 35196412-3 2022 Here, a universal solution synthesis method for preparing sulfide SEs from precursors, not only Li2 S, P2 S5 , LiCl, and Na2 S, but also metal sulfides (e.g., GeS2 and SnS2 ), fully dissolved in an alkahest: a mixture solvent of 1,2-ethylenediamine (EDA) and 1,2-ethanedithiol (EDT) (or ethanethiol). Sulfides 58-65 sodium voltage-gated channel alpha subunit 11 Homo sapiens 168-172 35113524-6 2022 The optimized Li2.6Er0.6Zr0.4Cl6 electrolyte exhibits both a high ionic conductivity of 1.13 mS cm-1 and a high oxidation voltage of 4.21 V. Furthermore, carbon additives are demonstrated to be beneficial for achieving high discharge capacity and better cycling stability and rate performance for halide-based ASSLIBs, which are completely different from the case of sulfide electrolytes. Sulfides 367-374 ATP binding cassette subfamily A member 12 Homo sapiens 14-17 35188390-2 2022 Here, by deploying the Chemical Linkage of Peptide onto Scaffolds strategy, we replaced the lactam cyclization of melanotan II (MT-II), a potent and unselective agonist of human MCRs (hMCRs), with different xylene-derived thioethers. Sulfides 222-232 metallothionein 2A Homo sapiens 128-133 35310092-9 2022 Several roles have been proposed for FXN: iron chaperone, gate-keeper of detrimental Fe-S cluster biosynthesis, sulfide production stimulator and sulfur transfer accelerator. Sulfides 112-119 frataxin Homo sapiens 37-40 35432913-3 2022 Here we report the use of the Random nonstandard Peptide Integrated Discovery (RaPID) mRNA display on a chemically cross-linked SARS-CoV-2 Mpro dimer, which yielded several high-affinity thioether-linked cyclic peptide inhibitors of the protease. Sulfides 187-196 NEWENTRY Severe acute respiratory syndrome-related coronavirus 139-143