PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12791997-2	2003	Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine-N-acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-kappaB pathway.	N-acetylmuramic acid	136-142	nucleotide binding oligomerization domain containing 1	Homo sapiens	25-29
16734789-10	2006	We provide the first evidence that the amidase indeed cleaves the amide bond between N-acetyl muramic acid and L-alanine.	N-acetylmuramic acid	85-106	AT695_RS13185	Staphylococcus aureus	39-46
15058963-2	2004	This large molecular "mesh" encases the entire cytoplasm of bacteria, and it is comprised of repeating backbone units of N-acetyl-glucosamine (NAG)-N-acetyl-muramic acid (NAM).	N-acetylmuramic acid	148-169	N-acetyl-alpha-glucosaminidase	Homo sapiens	121-141
15058963-2	2004	This large molecular "mesh" encases the entire cytoplasm of bacteria, and it is comprised of repeating backbone units of N-acetyl-glucosamine (NAG)-N-acetyl-muramic acid (NAM).	N-acetylmuramic acid	148-169	N-acetyl-alpha-glucosaminidase	Homo sapiens	143-146
14506276-4	2003	We report that human PGRP-L is a Zn2+-dependent N-acetylmuramoyl-l-alanine amidase (EC 3.5.1.28), an enzyme that hydrolyzes the amide bond between MurNAc and l-Ala of bacterial PGN.	N-acetylmuramic acid	147-153	peptidoglycan recognition protein 2	Homo sapiens	21-27
15791270-5	2005	We report that in both peptidoglycans, the minimal structure needed to activate the Toll pathway is a muropeptide dimer and that the free reducing end of the N-acetyl muramic acid residues of the muropeptides is essential for activity.	N-acetylmuramic acid	158-179	Toll	Drosophila melanogaster	84-88
3853967-2	1985	Values of inhibition maximum and dissociation constants of the reversible C3b-acceptor complex for blastolysin and main immunological active structural moieties of peptidoglycans (GMDP, MDP) and their inactive carbohydrate components (N-acetylglucosaminyl-N-acetylmuramic acid, N-acetylglucosamine, and N-acetylmuramic acid) have been determined.	N-acetylmuramic acid	256-276	endogenous retrovirus group K member 3	Homo sapiens	74-77
12198311-1	2002	Endolysin from the phage Cp-1 (Cpl-1) cleaves the glycosidic beta1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the pneumococcal cell wall.	N-acetylmuramic acid	87-107	lysozyme	Streptococcus phage Cp1	31-36
35446133-2	2022	Planktonic-phase E. faecalis is resistant to high concentrations of the enzyme lysozyme, which catalyzes the hydrolysis of N-acetylmuramic acid and N-acetylglucosamine linkages in peptidoglycan and is also a cationic antimicrobial peptide (CAMP).	N-acetylmuramic acid	123-143	lysozyme	Homo sapiens	79-87
35356735-4	2022	Lysozyme exerts antimicrobial activity against microorganisms, especially Gram-positive bacteria, by hydrolyzing 1,4-beta-linkages between N-acetylmuramic acid and N-acetylglucosamine in the cell wall.	N-acetylmuramic acid	139-159	lysozyme	Homo sapiens	0-8
7925454-8	1994	The analysis of cell wall digests indicated that P15 is a glycosidase that cleaves the beta (1-4) linkage between N-acetylmuramic acid and N-acetylglucosamine, thus displaying muramidase activity.	N-acetylmuramic acid	114-134	muramidase	Enterobacteria phage PRD1	49-52
7925454-8	1994	The analysis of cell wall digests indicated that P15 is a glycosidase that cleaves the beta (1-4) linkage between N-acetylmuramic acid and N-acetylglucosamine, thus displaying muramidase activity.	N-acetylmuramic acid	114-134	muramidase	Enterobacteria phage PRD1	176-186
1856865-0	1991	Lysozyme revisited: crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D. A structure of the trisaccharide 2-acetamido-2-deoxy-D-muramic acid-beta (1----4)-2-acetamido-2-deoxy-D-glucose-beta (1----4)-2-acetamido-2-deoxy-D-muramic acid (NAM-NAG-NAM), bound to subsites B, C and D in the active-site cleft of hen egg-white lysozyme has been determined and refined at 1.5 A resolution.	N-acetylmuramic acid	67-87	lysozyme	Homo sapiens	0-8
31566068-1	2020	Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT).	N-acetylmuramic acid	108-114	glutamic--pyruvic transaminase	Homo sapiens	226-229
6677186-8	1983	The lytic activity of lysozyme was ionic strength dependent and competitive inhibition was observed with both N-acetyl glucosamine and N-acetyl-muramic acid.	N-acetylmuramic acid	135-156	lysozyme C, tracheal isozyme	Bos taurus	22-30
5253664-5	1969	In addition, the binding to these sites of N-acetyl-D-muramic acid (NAM) and a cell-wall disaccharide, NAG-NAM, have been studied.	N-acetylmuramic acid	43-66	N-acetyl-alpha-glucosaminidase	Homo sapiens	103-106
19294463-5	2009	Lysozyme, widely present in body fluids, catalyzes the hydrolysis of beta 1,4 linkage between N-acetyloglucosamine and N-acetylmuramic acid in the bacterial cell wall and cooperates with the complement system in the bactericidal action of serum.	N-acetylmuramic acid	119-139	lysozyme	Homo sapiens	0-8
25480792-0	2015	The beta-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide.	N-acetylmuramic acid	144-150	lysR-type transcriptional regulator AmpR	Citrobacter freundii	34-38
25994146-1	2015	Lysozyme (EC 3.2.1.17) is a hydrolytic enzyme that cleaves the beta-(1,4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan, a major bacterial cell wall polymer.	N-acetylmuramic acid	98-118	lysozyme	Homo sapiens	0-8
30818346-2	2019	Among the many applications of lysozyme, the antibacterial activity features caused by the hydrolysis of 1-4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine of gram-positive bacteria are beneficial in the food industry, medicine, trade, and pharmacology.	N-acetylmuramic acid	134-154	lysozyme	Homo sapiens	31-39
30372997-3	2019	It is generally believed that the high efficiency of lysozyme in inhibiting gram-positive bacteria is caused by its ability to cleave the beta-(1,4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine.	N-acetylmuramic acid	173-193	lysozyme	Homo sapiens	53-61
28343137-1	2017	HYPOTHESIS: The interaction of lysozyme with the N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) unit of peptidoglycan (PGN) polymer of the bacterial cell wall is of immense importance to understand the mechanism of lysozyme on PGN.	N-acetylmuramic acid	49-69	lysozyme	Homo sapiens	31-39
28343137-1	2017	HYPOTHESIS: The interaction of lysozyme with the N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) unit of peptidoglycan (PGN) polymer of the bacterial cell wall is of immense importance to understand the mechanism of lysozyme on PGN.	N-acetylmuramic acid	49-69	lysozyme	Homo sapiens	225-233
28343137-1	2017	HYPOTHESIS: The interaction of lysozyme with the N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) unit of peptidoglycan (PGN) polymer of the bacterial cell wall is of immense importance to understand the mechanism of lysozyme on PGN.	N-acetylmuramic acid	71-74	lysozyme	Homo sapiens	31-39
28343137-1	2017	HYPOTHESIS: The interaction of lysozyme with the N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) unit of peptidoglycan (PGN) polymer of the bacterial cell wall is of immense importance to understand the mechanism of lysozyme on PGN.	N-acetylmuramic acid	71-74	lysozyme	Homo sapiens	225-233
26224458-8	2015	Also, THP-1 cells were co-treated with the LPS in the presence of N-acetylmuramic acid and N-acetylglucosamine, as components of PGN, and the competition binding assay to CD14 and LBP was performed.	N-acetylmuramic acid	66-86	CD14 molecule	Homo sapiens	171-175
26224458-9	2015	N-acetylmuramic acid inhibited the induction of inflammatory cytokine expression by LPS and the binding of LPS to CD14 or LBP whereas N-acetylglucosamine did not show such effect.	N-acetylmuramic acid	0-20	CD14 molecule	Homo sapiens	114-118
26224458-9	2015	N-acetylmuramic acid inhibited the induction of inflammatory cytokine expression by LPS and the binding of LPS to CD14 or LBP whereas N-acetylglucosamine did not show such effect.	N-acetylmuramic acid	0-20	lipopolysaccharide binding protein	Homo sapiens	122-125
26224458-11	2015	N-acetylmuramic acid of PGN may play a role in inhibition of the LPS binding of periodontopathogens to CD14 and LBP.	N-acetylmuramic acid	0-20	CD14 molecule	Homo sapiens	103-107
26224458-11	2015	N-acetylmuramic acid of PGN may play a role in inhibition of the LPS binding of periodontopathogens to CD14 and LBP.	N-acetylmuramic acid	0-20	lipopolysaccharide binding protein	Homo sapiens	112-115