PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12441138-3	2002	The general caspases inhibitor BD-fmk inhibits PARP cleavage but not cell death.	bd-fmk	31-37	caspase 2	Mus musculus	12-20
18384124-3	2008	Pan-caspase inhibitor BD-fmk blocked mIg-mediated increase in cells with sub-G1 DNA content, whereas it did not affect mIg-mediated loss of mitochondrial membrane potential and phosphatidylserine exposure on B cell membrane.	bd-fmk	22-28	chemokine (C-X-C motif) ligand 9	Mus musculus	37-40
15471953-5	2005	In contrast, the inhibitory activity of CD34+ cells could be reversed by adding the caspase inhibitor BD-FMK to the bulk MLR, indicating a deletion-based mechanism.	bd-fmk	102-108	CD34 molecule	Homo sapiens	40-44
15528132-4	2004	This tolerizing activity depends on cell contact and can be blocked by the caspase inhibitor BD-FMK, suggesting that the effector host T cells are deleted by apoptosis upon interaction with the CD34+ cells.	bd-fmk	93-99	CD34 molecule	Homo sapiens	194-198
14643888-6	2004	However, BD-fmk, a broad-spectrum caspase inhibitor, completely suppresses TGF-beta1-induced apoptosis, but unexpectedly does not inhibit TGF-beta1-induced PARP cleavage.	bd-fmk	9-15	transforming growth factor, beta 1	Mus musculus	75-84
12799285-4	2003	This tolerizing activity depends on cell contact and can be blocked by the caspase inhibitor BD-FMK, suggesting that the effector host T cells are deleted by apoptosis upon interaction with the CD34(+) cells.	bd-fmk	93-99	CD34 molecule	Homo sapiens	194-198
12441138-3	2002	The general caspases inhibitor BD-fmk inhibits PARP cleavage but not cell death.	bd-fmk	31-37	poly (ADP-ribose) polymerase family, member 1	Mus musculus	47-51
11278808-6	2001	Furthermore, inhibition of caspase activity by the broad spectrum caspase inhibitor BD-fmk significantly attenuated the Par-4-induced increase in Abeta 1-42 production.	bd-fmk	84-90	pro-apoptotic WT1 regulator	Homo sapiens	120-125
10753878-5	2000	NF-kappaB activation by FADD and Casper is inhibited by the caspase-specific inhibitors crmA and BD-fmk, suggesting that FADD- and Casper-induced NF-kappaB activation is mediated by caspase-8.	bd-fmk	97-103	Fas associated via death domain	Homo sapiens	24-28
10753878-5	2000	NF-kappaB activation by FADD and Casper is inhibited by the caspase-specific inhibitors crmA and BD-fmk, suggesting that FADD- and Casper-induced NF-kappaB activation is mediated by caspase-8.	bd-fmk	97-103	CASP8 and FADD like apoptosis regulator	Homo sapiens	33-39
10753878-5	2000	NF-kappaB activation by FADD and Casper is inhibited by the caspase-specific inhibitors crmA and BD-fmk, suggesting that FADD- and Casper-induced NF-kappaB activation is mediated by caspase-8.	bd-fmk	97-103	Fas associated via death domain	Homo sapiens	121-125
10753878-5	2000	NF-kappaB activation by FADD and Casper is inhibited by the caspase-specific inhibitors crmA and BD-fmk, suggesting that FADD- and Casper-induced NF-kappaB activation is mediated by caspase-8.	bd-fmk	97-103	CASP8 and FADD like apoptosis regulator	Homo sapiens	131-137
10753878-5	2000	NF-kappaB activation by FADD and Casper is inhibited by the caspase-specific inhibitors crmA and BD-fmk, suggesting that FADD- and Casper-induced NF-kappaB activation is mediated by caspase-8.	bd-fmk	97-103	caspase 8	Homo sapiens	182-191
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	TNF receptor superfamily member 1A	Homo sapiens	89-95
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	TNFRSF1A associated via death domain	Homo sapiens	98-103
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	tumor necrosis factor	Homo sapiens	89-92
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	Fas associated via death domain	Homo sapiens	159-163
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	CASP8 and FADD like apoptosis regulator	Homo sapiens	165-171
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	caspase 8	Homo sapiens	177-186
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	TNFRSF1A associated via death domain	Homo sapiens	210-215
10753878-8	2000	A mutant of Casper and the caspase-specific inhibitors crmA and BD-fmk partially inhibit TNF-R1-, TRADD, and TNF-induced NF-kappaB activation, suggesting that FADD, Casper, and caspase-8 function downstream of TRADD and contribute to TNF-R1-induced NF-kappaB activation.	bd-fmk	64-70	TNF receptor superfamily member 1A	Homo sapiens	234-240
8976202-2	1996	The CPP-32-like protease activity in apoptotic cell lysates was blocked by both the ICE inhibitor Cbz-Val-Ala-Asp(OMe)-fluoromethyl ketone (ZVAD-FMK) as well as its truncated analog Boc-Asp(OMe)-fluoromethyl ketone (BD-FMK), which failed to block ICE.	bd-fmk	216-222	caspase 3	Mus musculus	4-10
9790498-6	1998	The broad spectrum caspase inhibitor BD-fmk, but not tetrapeptide inhibitors of specific caspases, completely blocks TGFbeta-induced apoptosis while maintaining cellular viability.	bd-fmk	37-43	transforming growth factor, beta 1	Mus musculus	117-124
8976202-2	1996	The CPP-32-like protease activity in apoptotic cell lysates was blocked by both the ICE inhibitor Cbz-Val-Ala-Asp(OMe)-fluoromethyl ketone (ZVAD-FMK) as well as its truncated analog Boc-Asp(OMe)-fluoromethyl ketone (BD-FMK), which failed to block ICE.	bd-fmk	216-222	caspase 1	Mus musculus	84-87
8976202-3	1996	In vitro apoptotic death in murine thymocytes triggered by the independent agents dexamethasone, etoposide, radiation, anti-Fas, and anti-CD3 was blocked equally well by BD-FMK and ZVAD-FMK, but not by the control reagent Cbz-Phe-Ala-fluoromethyl ketone.	bd-fmk	170-176	CD3 antigen, epsilon polypeptide	Mus musculus	138-141
8976202-4	1996	In activated T cell blasts, while anti-CD3/ Fas-induced death was almost completely inhibited by both ZVAD-FMK, and BD-FMK, death induced by dexamethasone, etoposide, or irradiation was more sensitive to inhibition by BD-FMK.	bd-fmk	116-122	CD3 antigen, epsilon polypeptide	Mus musculus	39-42
8976202-4	1996	In activated T cell blasts, while anti-CD3/ Fas-induced death was almost completely inhibited by both ZVAD-FMK, and BD-FMK, death induced by dexamethasone, etoposide, or irradiation was more sensitive to inhibition by BD-FMK.	bd-fmk	218-224	CD3 antigen, epsilon polypeptide	Mus musculus	39-42
8976202-5	1996	In the murine T cell line CTLL-2, apoptotic death induced by IL-2 withdrawal, etoposide, or dexamethasone was inhibited by BD-FMK, while ZVAD-FMK was without effect.	bd-fmk	123-129	interleukin 2	Mus musculus	61-65