PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21265894-1	2011	Soil-living rhizobia secrete lipochitin oligosaccharides known as Nod factors, which in Lotus japonicus are perceived by at least two Nod-factor receptors, NFR1 and NFR5.	lipid-linked oligosaccharides	29-56	Nod-factor receptor 1b	Lotus japonicus	156-160
21747781-6	2011	We found that a transposon insertion in the lgtD gene, which encodes an N-acetylgalactosamine transferase involved in the extension of the alpha-chain of lipooligosaccharide (LOS), could confer decreased susceptibility of strain F62 to complement-mediated killing by NHS.	lipid-linked oligosaccharides	154-173	Fc gamma receptor and transporter	Homo sapiens	139-150
21265894-1	2011	Soil-living rhizobia secrete lipochitin oligosaccharides known as Nod factors, which in Lotus japonicus are perceived by at least two Nod-factor receptors, NFR1 and NFR5.	lipid-linked oligosaccharides	29-56	NFR5	Lotus japonicus	165-169
21821951-3	2011	Domain EXFGI/L/VX(2)L/VE in the Hmat-Xa protein, also present in both human mannosyltransferase II/III and mannosyltransferase IV/V, which are involved in the synthesis of lipid-linked oligosaccharides, and some bacterial mannosyltransferases.	lipid-linked oligosaccharides	172-201	glycosyltransferase like domain containing 1	Homo sapiens	32-39
17250593-0	2007	Neisseria meningitidis type C capsular polysaccharide inhibits lipooligosaccharide-induced cell activation by binding to CD14.	lipid-linked oligosaccharides	63-82	CD14 molecule	Homo sapiens	121-125
21329806-2	2011	UPR transducers IRE1, PERK, ATF6, and UPR-responsive genes such as GRP78/BiP, ERAD genes such as EDEM, and synthesis of the protein N-linked glycosylation donor lipid-linked oligosaccharides (LLOs) are mobilized.	lipid-linked oligosaccharides	192-196	heat shock protein family A (Hsp70) member 5	Homo sapiens	67-72
21329806-2	2011	UPR transducers IRE1, PERK, ATF6, and UPR-responsive genes such as GRP78/BiP, ERAD genes such as EDEM, and synthesis of the protein N-linked glycosylation donor lipid-linked oligosaccharides (LLOs) are mobilized.	lipid-linked oligosaccharides	192-196	heat shock protein family A (Hsp70) member 5	Homo sapiens	73-76
20356820-5	2010	Complementation analysis showed that AtALG3 rescued the temperature-sensitive phenotype, that lipid-linked oligosaccharide assemblies and that protein underglycosylation of S. cerevisiae ALG3-deficient mutant.	lipid-linked oligosaccharides	94-122	asparagine-linked glycosylation 3	Arabidopsis thaliana	37-43
20356820-5	2010	Complementation analysis showed that AtALG3 rescued the temperature-sensitive phenotype, that lipid-linked oligosaccharide assemblies and that protein underglycosylation of S. cerevisiae ALG3-deficient mutant.	lipid-linked oligosaccharides	94-122	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	39-43
20356820-6	2010	In Arabidopsis ALG3 mutant, an immature lipid-linked oligosaccharide structure, M5(ER), was synthesized, and used for protein N-glycosylation, resulting in the blockade of subsequent maturation with the concanavalin A affinoactive and Endo H-insensitive structure.	lipid-linked oligosaccharides	40-68	asparagine-linked glycosylation 3	Arabidopsis thaliana	15-19
19928913-3	2009	Molecules that inhibited TLR4 activation inhibited LBP.CD14-dependent transfer of endotoxin monomers derived from aggregates of tritiated lipooligosaccharide ([(3)H]LOS) from Neisseria meninigitidis to MD-2.TLR4, resulting in a reduced level of formation of a ([(3)H]LOS.MD-2.TLR4(ECD))(2) (M(r) approximately 190000) complex.	lipid-linked oligosaccharides	138-157	toll like receptor 4	Homo sapiens	25-29
19928913-3	2009	Molecules that inhibited TLR4 activation inhibited LBP.CD14-dependent transfer of endotoxin monomers derived from aggregates of tritiated lipooligosaccharide ([(3)H]LOS) from Neisseria meninigitidis to MD-2.TLR4, resulting in a reduced level of formation of a ([(3)H]LOS.MD-2.TLR4(ECD))(2) (M(r) approximately 190000) complex.	lipid-linked oligosaccharides	138-157	lipopolysaccharide binding protein	Homo sapiens	51-54
19928913-3	2009	Molecules that inhibited TLR4 activation inhibited LBP.CD14-dependent transfer of endotoxin monomers derived from aggregates of tritiated lipooligosaccharide ([(3)H]LOS) from Neisseria meninigitidis to MD-2.TLR4, resulting in a reduced level of formation of a ([(3)H]LOS.MD-2.TLR4(ECD))(2) (M(r) approximately 190000) complex.	lipid-linked oligosaccharides	138-157	CD14 molecule	Homo sapiens	55-59
19835842-5	2009	For this purpose, the different subunits of the OST complex were screened in 27 CDG-Ix patients for whom structural analysis of the lipid-linked oligosaccharides revealed a normal level and intact structure of the oligosaccharide precursor.	lipid-linked oligosaccharides	132-161	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	48-51
19681908-0	2009	N-glycosylated proteins and distinct lipooligosaccharide glycoforms of Campylobacter jejuni target the human C-type lectin receptor MGL.	lipid-linked oligosaccharides	37-56	C-type lectin domain containing 10A	Homo sapiens	132-135
19681908-8	2009	Collectively, our results provide evidence that both N-linked glycoproteins and distinct lipooligosaccharide glycoforms of C. jejuni are ligands for the human C-type lectin MGL and that the C. jejuni N-glycosylation machinery can be exploited to target recombinant bacteria to MGL-expressing eukaryotic cells.	lipid-linked oligosaccharides	89-108	C-type lectin domain containing 10A	Homo sapiens	173-176
19491094-0	2009	Mycobacterium marinum lipooligosaccharides are unique caryophyllose-containing cell wall glycolipids that inhibit tumor necrosis factor-alpha secretion in macrophages.	lipid-linked oligosaccharides	22-42	tumor necrosis factor	Homo sapiens	114-141
19079182-0	2008	TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells.	lipid-linked oligosaccharides	16-36	triggering receptor expressed on myeloid cells 2	Homo sapiens	0-6
19079182-4	2008	Far-western blots of gonococcal outer membranes revealed TREM-2A binding to lipooligosaccharide (LOS) and opacity (Opa) protein, with predominant binding to LOS.	lipid-linked oligosaccharides	76-95	triggering receptor expressed on myeloid cells 2	Homo sapiens	57-64
18386389-3	2008	Previously, we demonstrated that H. somni and its lipooligosaccharide (LOS) activate bovine platelets, leading to expression of P selectin, CD40L, and FasL.	lipid-linked oligosaccharides	50-69	selectin P	Bos taurus	128-138
18386389-3	2008	Previously, we demonstrated that H. somni and its lipooligosaccharide (LOS) activate bovine platelets, leading to expression of P selectin, CD40L, and FasL.	lipid-linked oligosaccharides	50-69	CD40 ligand	Bos taurus	140-145
18386389-3	2008	Previously, we demonstrated that H. somni and its lipooligosaccharide (LOS) activate bovine platelets, leading to expression of P selectin, CD40L, and FasL.	lipid-linked oligosaccharides	71-74	selectin P	Bos taurus	128-138
18386389-3	2008	Previously, we demonstrated that H. somni and its lipooligosaccharide (LOS) activate bovine platelets, leading to expression of P selectin, CD40L, and FasL.	lipid-linked oligosaccharides	71-74	CD40 ligand	Bos taurus	140-145
21329806-2	2011	UPR transducers IRE1, PERK, ATF6, and UPR-responsive genes such as GRP78/BiP, ERAD genes such as EDEM, and synthesis of the protein N-linked glycosylation donor lipid-linked oligosaccharides (LLOs) are mobilized.	lipid-linked oligosaccharides	161-190	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	16-20
21329806-2	2011	UPR transducers IRE1, PERK, ATF6, and UPR-responsive genes such as GRP78/BiP, ERAD genes such as EDEM, and synthesis of the protein N-linked glycosylation donor lipid-linked oligosaccharides (LLOs) are mobilized.	lipid-linked oligosaccharides	161-190	heat shock protein family A (Hsp70) member 5	Homo sapiens	67-72
21329806-2	2011	UPR transducers IRE1, PERK, ATF6, and UPR-responsive genes such as GRP78/BiP, ERAD genes such as EDEM, and synthesis of the protein N-linked glycosylation donor lipid-linked oligosaccharides (LLOs) are mobilized.	lipid-linked oligosaccharides	161-190	heat shock protein family A (Hsp70) member 5	Homo sapiens	73-76
21329806-2	2011	UPR transducers IRE1, PERK, ATF6, and UPR-responsive genes such as GRP78/BiP, ERAD genes such as EDEM, and synthesis of the protein N-linked glycosylation donor lipid-linked oligosaccharides (LLOs) are mobilized.	lipid-linked oligosaccharides	192-196	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	16-20
21266840-7	2011	In contrast, the lipooligosaccharide mutant showed increased sensitivity to polymyxin B, alpha-defensins, cathelicidins, and BPI.	lipid-linked oligosaccharides	17-36	bactericidal permeability increasing protein	Homo sapiens	125-128
21050116-2	2010	Here we demonstrate that, in contrast to the common Bordetella pertussis laboratory strain and Tohama I derivative BP338, lipooligosaccharide from mouse challenge strain 18-323 is a poor inducer of inflammatory cytokines in human and murine macrophages, is greatly impaired in Toll-like receptor 4-mediated activation of nuclear factor-kappaB in transfected HEK-293 cells, and functions as a Toll-like receptor 4 antagonist.	lipid-linked oligosaccharides	122-141	toll like receptor 4	Homo sapiens	277-297
21050116-2	2010	Here we demonstrate that, in contrast to the common Bordetella pertussis laboratory strain and Tohama I derivative BP338, lipooligosaccharide from mouse challenge strain 18-323 is a poor inducer of inflammatory cytokines in human and murine macrophages, is greatly impaired in Toll-like receptor 4-mediated activation of nuclear factor-kappaB in transfected HEK-293 cells, and functions as a Toll-like receptor 4 antagonist.	lipid-linked oligosaccharides	122-141	toll like receptor 4	Homo sapiens	392-412
20686663-9	2010	Progressive truncation of the heptose (Hep) I chain of lipooligosaccharide (LOS), or sialylation of lacto-N-neotetraose LOS both increased fH binding to NspA-expressing meningococci, while expression of capsule reduced fH binding to the strains tested.	lipid-linked oligosaccharides	76-79	complement factor H	Homo sapiens	139-141
17984207-2	2008	We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for complement C4b.	lipid-linked oligosaccharides	25-44	complement C4B (Chido blood group)	Homo sapiens	101-104
17690687-5	2007	Using L. japonicus mutants and domain swaps between L. japonicus and L. filicaulis NFR1 and NFR5, we further demonstrate that LysM domains of the NFR1 and NFR5 receptors mediate perception of the bacterial Nod-factor signal and that recognition depends on the structure of the lipochitin-oligosaccharide Nod-factor.	lipid-linked oligosaccharides	277-303	Nod-factor receptor 1b	Lotus japonicus	146-150
17690687-5	2007	Using L. japonicus mutants and domain swaps between L. japonicus and L. filicaulis NFR1 and NFR5, we further demonstrate that LysM domains of the NFR1 and NFR5 receptors mediate perception of the bacterial Nod-factor signal and that recognition depends on the structure of the lipochitin-oligosaccharide Nod-factor.	lipid-linked oligosaccharides	277-303	NFR5	Lotus japonicus	155-159
17690687-6	2007	We show that a single amino-acid variation in the LysM2 domain of NFR5 changes recognition of the Nod-factor synthesized by the DZL strain and suggests a possible binding site for bacterial lipochitin-oligosaccharide signal molecules.	lipid-linked oligosaccharides	190-216	NFR5	Lotus japonicus	66-70
17545685-2	2007	MD-2 interacts with lipid A of endotoxins [lipopolysaccharide (LPS) or lipooligosaccharide (LOS)] to activate human toll-like receptor (TLR) 4.	lipid-linked oligosaccharides	71-90	lymphocyte antigen 96	Homo sapiens	0-4
17026481-0	2007	Non-lipooligosaccharide-mediated signalling via Toll-like receptor 4 causes fatal meningococcal sepsis in a mouse model.	lipid-linked oligosaccharides	4-23	toll-like receptor 4	Mus musculus	48-68
15489357-6	2004	Gonococci invade the nonciliated epithelia, and the ciliated cells are subjected to the cytotoxic effects of tumor necrosis factor alpha induced by gonococcal peptidoglycan and lipooligosaccharide.	lipid-linked oligosaccharides	177-196	tumor necrosis factor	Homo sapiens	109-136
16325265-1	2006	Haemophilus somnus lipooligosaccharide (LOS)-induced apoptosis of bovine pulmonary artery endothelial cells has been shown previously to be dependent on caspase-8 activation.	lipid-linked oligosaccharides	40-43	caspase 8	Bos taurus	153-162
16041130-3	2005	The ALG6, ALG8, and ALG10 genes encode the glucosyltransferases necessary for the completion of the synthesis of the lipid-linked oligosaccharide used for the asparagine-linked glycosylation of proteins in that order.	lipid-linked oligosaccharides	117-145	dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Saccharomyces cerevisiae S288C	4-8
16041130-3	2005	The ALG6, ALG8, and ALG10 genes encode the glucosyltransferases necessary for the completion of the synthesis of the lipid-linked oligosaccharide used for the asparagine-linked glycosylation of proteins in that order.	lipid-linked oligosaccharides	117-145	dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Saccharomyces cerevisiae S288C	10-14
16041130-3	2005	The ALG6, ALG8, and ALG10 genes encode the glucosyltransferases necessary for the completion of the synthesis of the lipid-linked oligosaccharide used for the asparagine-linked glycosylation of proteins in that order.	lipid-linked oligosaccharides	117-145	dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase	Saccharomyces cerevisiae S288C	20-25
15647513-4	2005	In the present study, we examine eight mouse models of lysosomal storage disorders by modern FACE and found striking lipid-linked oligosaccharide (LLO) accumulation in NCL mouse models (especially CLN1, CLN6, and CLN8 knockout or mutant mice) but not in several other lysosomal storage disorders affecting the brain.	lipid-linked oligosaccharides	147-150	nucleolin	Mus musculus	168-171
15647513-4	2005	In the present study, we examine eight mouse models of lysosomal storage disorders by modern FACE and found striking lipid-linked oligosaccharide (LLO) accumulation in NCL mouse models (especially CLN1, CLN6, and CLN8 knockout or mutant mice) but not in several other lysosomal storage disorders affecting the brain.	lipid-linked oligosaccharides	147-150	palmitoyl-protein thioesterase 1	Mus musculus	197-201
15647513-4	2005	In the present study, we examine eight mouse models of lysosomal storage disorders by modern FACE and found striking lipid-linked oligosaccharide (LLO) accumulation in NCL mouse models (especially CLN1, CLN6, and CLN8 knockout or mutant mice) but not in several other lysosomal storage disorders affecting the brain.	lipid-linked oligosaccharides	147-150	CLN8 transmembrane ER and ERGIC protein	Mus musculus	213-217
15794922-2	2005	N-glycans originate from a common lipid-linked oligosaccharide (LLO) precursor whose synthesis is initiated by the Dol-P-dependent GlcNAc-1-P transferase (GPT) encoded by an essential ALG7 gene.	lipid-linked oligosaccharides	34-62	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	Saccharomyces cerevisiae S288C	184-188
15794922-2	2005	N-glycans originate from a common lipid-linked oligosaccharide (LLO) precursor whose synthesis is initiated by the Dol-P-dependent GlcNAc-1-P transferase (GPT) encoded by an essential ALG7 gene.	lipid-linked oligosaccharides	64-67	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	Saccharomyces cerevisiae S288C	184-188
16237099-4	2005	Nontypeable Haemophilus influenzae (NTHi) is a common Gram-negative respiratory pathogen that expresses both TLR4 (LPS and lipooligosaccharide) and TLR2 (lipoproteins) ligands.	lipid-linked oligosaccharides	123-142	toll-like receptor 4	Mus musculus	109-113
16100113-0	2005	Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolichol.	lipid-linked oligosaccharides	16-45	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13	Saccharomyces cerevisiae S288C	75-81
16100113-0	2005	Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolichol.	lipid-linked oligosaccharides	16-45	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14	Saccharomyces cerevisiae S288C	86-92
15639192-3	2005	Labeling of the patients" lipid-linked oligosaccharides suggested mutations in the hALG12 gene, encoding a mannosyltransferase.	lipid-linked oligosaccharides	26-55	ALG12 alpha-1,6-mannosyltransferase	Homo sapiens	83-89
15231263-3	2004	Flavonoids from the plant root trigger bacterial gene expression and the production of lipo-chitooligosaccharide signals (called Nod factors) that are recognized by the plant host.	lipid-linked oligosaccharides	87-112	atrophin 1	Homo sapiens	129-132
15277677-7	2004	Immunization of mice with the lipooligosaccharide generated a mAb that reacted with GM1 and bound to human peripheral nerves.	lipid-linked oligosaccharides	30-49	coenzyme Q10A	Mus musculus	84-87
14709599-7	2004	The accumulation pattern suggested a deficiency of the ALG1 beta1,4 mannosyltransferase, which adds the first mannose residue to lipid-linked oligosaccharides.	lipid-linked oligosaccharides	129-158	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	55-59
15148656-6	2004	The ALG9 defect found in the patient with CDG--who presented with developmental delay, hypotonia, seizures, and hepatomegaly--shows that efficient lipid-linked oligosaccharide synthesis is required for proper human development and physiology.	lipid-linked oligosaccharides	147-175	ALG9 alpha-1,2-mannosyltransferase	Homo sapiens	4-8
14534578-6	2003	We show that NFR1 and NFR5 are required for the earliest physiological and cellular responses to this lipochitin-oligosaccharide signal, and demonstrate their role in the mechanism establishing susceptibility of the legume root for bacterial infection.	lipid-linked oligosaccharides	102-128	Nod-factor receptor 1b	Lotus japonicus	13-17
12819075-0	2003	Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.	lipid-linked oligosaccharides	98-117	toll like receptor 2	Homo sapiens	14-34
14534578-6	2003	We show that NFR1 and NFR5 are required for the earliest physiological and cellular responses to this lipochitin-oligosaccharide signal, and demonstrate their role in the mechanism establishing susceptibility of the legume root for bacterial infection.	lipid-linked oligosaccharides	102-128	NFR5	Lotus japonicus	22-26
12819075-0	2003	Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.	lipid-linked oligosaccharides	98-117	toll like receptor 2	Homo sapiens	36-40
12819075-0	2003	Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.	lipid-linked oligosaccharides	98-117	toll like receptor 4	Homo sapiens	46-50
12819075-0	2003	Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.	lipid-linked oligosaccharides	98-117	lymphocyte antigen 96	Homo sapiens	51-54
12183584-1	2002	Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human beta-defensin 2 (HBD-2) compared to the wild type.	lipid-linked oligosaccharides	42-61	defensin beta 4A	Homo sapiens	137-152
12183584-1	2002	Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human beta-defensin 2 (HBD-2) compared to the wild type.	lipid-linked oligosaccharides	42-61	defensin beta 4A	Homo sapiens	154-159
11733556-3	2001	CDG-If is caused by a defect in the gene MPDU1, the human homologue of hamster Lec35, and is the first disorder to affect the use, rather than the biosynthesis, of donor substrates for lipid-linked oligosaccharides.	lipid-linked oligosaccharides	185-214	mannose-P-dolichol utilization defect 1	Homo sapiens	0-6
11807558-0	2002	Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein.	lipid-linked oligosaccharides	17-46	glycolipid translocation protein	Saccharomyces cerevisiae S288C	79-83
11733556-3	2001	CDG-If is caused by a defect in the gene MPDU1, the human homologue of hamster Lec35, and is the first disorder to affect the use, rather than the biosynthesis, of donor substrates for lipid-linked oligosaccharides.	lipid-linked oligosaccharides	185-214	mannose-P-dolichol utilization defect 1	Homo sapiens	41-46
11520056-2	2001	In all eukaryotes, N-glycosylation utilizes the lipid-linked oligosaccharide (LLO) precursor, whose synthesis is initiated by the ALG7 gene.	lipid-linked oligosaccharides	48-76	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	Saccharomyces cerevisiae S288C	130-134
11520056-2	2001	In all eukaryotes, N-glycosylation utilizes the lipid-linked oligosaccharide (LLO) precursor, whose synthesis is initiated by the ALG7 gene.	lipid-linked oligosaccharides	78-81	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	Saccharomyces cerevisiae S288C	130-134
10496940-2	1999	Outer membrane proteins (OMP) and lipooligosaccharide (LOS) are major surface antigens of NTHi and potential vaccine candidates.	lipid-linked oligosaccharides	34-53	midline	Drosophila melanogaster	55-58
10857602-5	2000	Examples are given to demonstrate the feasibility of applying STAT to MSn data generated from bacterial lipooligosaccharides and an N-linked glycan.	lipid-linked oligosaccharides	104-124	moesin	Homo sapiens	70-73
10844691-1	2000	In the present study, we show that Neisseria gonorrhoeae lipooligosaccharide (LOS) can bind to the asialoglycoprotein receptor (ASGP-R) on human sperm.	lipid-linked oligosaccharides	78-81	asialoglycoprotein receptor 1	Homo sapiens	99-126
10844691-1	2000	In the present study, we show that Neisseria gonorrhoeae lipooligosaccharide (LOS) can bind to the asialoglycoprotein receptor (ASGP-R) on human sperm.	lipid-linked oligosaccharides	78-81	mucin 4, cell surface associated	Homo sapiens	128-132
11308030-0	2001	Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.	lipid-linked oligosaccharides	16-45	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	60-64
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	127-156	mannose-P-dolichol utilization defect 1	Homo sapiens	4-9
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	127-156	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	127-156	mevalonate diphosphate decarboxylase	Homo sapiens	81-99
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	127-156	mevalonate diphosphate decarboxylase	Homo sapiens	101-104
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	158-162	mannose-P-dolichol utilization defect 1	Homo sapiens	4-9
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	158-162	mannose-P-dolichol utilization defect 1	Homo sapiens	24-30
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	158-162	mevalonate diphosphate decarboxylase	Homo sapiens	81-99
11179430-1	2001	The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively.	lipid-linked oligosaccharides	158-162	mevalonate diphosphate decarboxylase	Homo sapiens	101-104
10561453-3	1999	Lipid-linked oligosaccharides in mutant 1116 were labeled with [6-(3)H]glucosamine and [2-(3)H]mannose, prepared by cycles of solvent extraction, and analyzed by gel filtration chromatography on a Bio-Gel P-4 column after mild acid-hydrolysis.	lipid-linked oligosaccharides	0-29	exosome component 10	Homo sapiens	205-208
11038524-1	1996	Lipochitooligosaccharides (LCOs) are a novel class of plant growth regulators that activate in tobacco protoplasts the expression of AXI1, a gene implicated in auxin signaling.	lipid-linked oligosaccharides	0-25	uncharacterized protein At1g04910-like	Nicotiana tabacum	133-137
9597543-0	1998	The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation.	lipid-linked oligosaccharides	144-172	dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase	Saccharomyces cerevisiae S288C	4-9
9364907-3	1997	Nod factors are lipo-chitooligosaccharides (LCOs) varying in the oligosaccharide chain length, the nature of the fatty acids and substitutions on the oligosaccharide.	lipid-linked oligosaccharides	16-42	atrophin 1	Homo sapiens	0-3
9364907-3	1997	Nod factors are lipo-chitooligosaccharides (LCOs) varying in the oligosaccharide chain length, the nature of the fatty acids and substitutions on the oligosaccharide.	lipid-linked oligosaccharides	44-48	atrophin 1	Homo sapiens	0-3
9650293-7	1998	Here we show that when expressed in NGR234 cured of its symbiotic plasmid (= ANU265) or when purified as a fusion protein (MBP-NoeE), NoeE transfers sulfate from PAPS to fucosylated lipochitin-oligosaccharides.	lipid-linked oligosaccharides	182-209	nodulation protein NoeE	Sinorhizobium fredii NGR234	134-138
11038524-1	1996	Lipochitooligosaccharides (LCOs) are a novel class of plant growth regulators that activate in tobacco protoplasts the expression of AXI1, a gene implicated in auxin signaling.	lipid-linked oligosaccharides	27-31	uncharacterized protein At1g04910-like	Nicotiana tabacum	133-137
8939723-1	1996	Lipochitooligosaccharides (Nod signals) excreted by rhizobia induce the formation of symbiotic root nodules in leguminous plants.	lipid-linked oligosaccharides	0-25	atrophin 1	Homo sapiens	27-30
7588624-7	1995	In stt3-3 cells very little glycosyl transfer occurs from incomplete lipid-linked oligosaccharide, whereas the transfer of full-length Glc3Man9GlcNAc2 is hardly affected as compared with wild-type cells.	lipid-linked oligosaccharides	69-97	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	3-7
8692962-0	1996	Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase.	lipid-linked oligosaccharides	25-53	dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase	Saccharomyces cerevisiae S288C	134-138
8842708-8	1996	The isolated ALG3 gene complements both the defect in the biosynthesis of lipid-linked oligosaccharides of the alg3-mutant and the under-glycosylation of secretory proteins.	lipid-linked oligosaccharides	74-103	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	13-17
8842708-8	1996	The isolated ALG3 gene complements both the defect in the biosynthesis of lipid-linked oligosaccharides of the alg3-mutant and the under-glycosylation of secretory proteins.	lipid-linked oligosaccharides	74-103	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	111-115
24415161-2	1996	In addition, the role of numerous nod genes in the biosynthesis of the lipooligosaccharides has been identified.	lipid-linked oligosaccharides	71-91	atrophin 1	Homo sapiens	34-37
8016100-0	1994	New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus.	lipid-linked oligosaccharides	61-89	dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Saccharomyces cerevisiae S288C	106-110
7593165-8	1995	Microsomal membranes isolated from ost2 mutant yeast show marked reductions in the in vitro transfer of high mannose oligosaccharide from exogenous lipid-linked oligosaccharide to a glycosylation site acceptor tripeptide.	lipid-linked oligosaccharides	148-176	dolichyl-diphosphooligosaccharide-protein glycotransferase	Saccharomyces cerevisiae S288C	35-39
7890416-1	1995	One of the lipooligosaccharide (LOS) structures of Neisseria gonorrhoeae contains a terminal Gal(beta 1-4)GlcNAc residue which is a good candidate to serve as a ligand for human asialoglycoprotein receptors (ASGP-R).	lipid-linked oligosaccharides	11-30	asialoglycoprotein receptor 1	Homo sapiens	178-206
7890416-1	1995	One of the lipooligosaccharide (LOS) structures of Neisseria gonorrhoeae contains a terminal Gal(beta 1-4)GlcNAc residue which is a good candidate to serve as a ligand for human asialoglycoprotein receptors (ASGP-R).	lipid-linked oligosaccharides	11-30	asialoglycoprotein receptor 1	Homo sapiens	208-214
7890416-6	1995	Using well-established assays for the utilization of the ASGP-R, we found that incubation of HepG2 cells with gonococci expressing the terminal Gal(beta 1-4)GlcNAc asialo-LOS carbohydrate structure competitively inhibited the ASGP-R from binding to one of its well-known ligands, asialo-alpha-acid-1-glycoprotein.	lipid-linked oligosaccharides	171-174	asialoglycoprotein receptor 1	Homo sapiens	57-63
7860628-8	1995	Microsomal membranes isolated from ost1 mutant yeast showed marked reductions in the in vitro transfer of high mannose oligosaccharide from exogenous lipid-linked oligosaccharide to a glycosylation site acceptor tripeptide.	lipid-linked oligosaccharides	150-178	dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1	Saccharomyces cerevisiae S288C	35-39
8016100-3	1994	When these mutations were introduced into a strain with reduced oligosaccharyltransferase activity (due to the wbp1-1 mutation), a severe growth defect was observed: accumulation of suboptimal lipid-linked oligosaccharide and reduced oligosaccharyltransferase activity resulted in a severe underglycosylation of secreted proteins.	lipid-linked oligosaccharides	193-221	dolichyl-diphosphooligosaccharide-protein glycotransferase	Saccharomyces cerevisiae S288C	111-117
8400550-1	1993	In the yeast Saccharomyces cerevisiae, the alg2 mutation causes temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol (Jackson et al., Arch.	lipid-linked oligosaccharides	126-154	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	43-47
8193150-0	1994	The adhesive specificity of the soluble human lectin, IgE-binding protein, toward lipid-linked oligosaccharides.	lipid-linked oligosaccharides	82-111	galectin 3	Homo sapiens	54-73
8400550-9	1993	Alg2 mutants transformed with plasmids containing ALG2 regained the capacity to grow and to synthesize lipid-linked oligosaccharides normally at the previously non-permissive temperature.	lipid-linked oligosaccharides	103-132	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	0-4
8400550-9	1993	Alg2 mutants transformed with plasmids containing ALG2 regained the capacity to grow and to synthesize lipid-linked oligosaccharides normally at the previously non-permissive temperature.	lipid-linked oligosaccharides	103-132	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	50-54
2474610-10	1989	Western immunoblots of whole cell lysates, outer membrane complex, and purified lipooligosaccharide showed that the bactericidal IgA1 was specific for several outer membrane proteins.	lipid-linked oligosaccharides	80-99	immunoglobulin heavy constant alpha 1	Homo sapiens	129-133
2138781-5	1990	Microsomal membranes from a mutant strain that synthesized glucosylphosphodolichol but lacked the ability to transfer the glucosyl residue to the growing lipid-linked oligosaccharide (alg6) exhibited labeling with 5-azido[beta-32P]UDPGlc comparable to that found in microsomes from the wild-type strain.	lipid-linked oligosaccharides	154-182	dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Saccharomyces cerevisiae S288C	184-188
34561304-5	2021	We demonstrate that HAAs are sensed by the bulb-type lectin receptor kinase LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION/S-DOMAIN-1-29 (LORE/SD1-29), which also mediates medium-chain 3-hydroxy fatty acid (mc-3-OH-FA) perception, in the plant Arabidopsis thaliana HAA sensing induces canonical immune signaling and local resistance to plant pathogenic Pseudomonas infection.	lipid-linked oligosaccharides	76-95	S-domain-1 29	Arabidopsis thaliana	145-151
1384480-0	1992	High affinity binding of the leucocyte adhesion molecule L-selectin to 3"-sulphated-Le(a) and -Le(x) oligosaccharides and the predominance of sulphate in this interaction demonstrated by binding studies with a series of lipid-linked oligosaccharides.	lipid-linked oligosaccharides	220-249	selectin L	Homo sapiens	57-67
1384480-1	1992	The binding of the leucocyte adhesion molecule L-selectin has been investigated toward several structurally defined lipid-linked oligosaccharides immobilized on silica gel chromatograms or plastic wells.	lipid-linked oligosaccharides	116-145	selectin L	Homo sapiens	47-57
1711080-0	1991	Lysis of Neisseria gonorrhoeae initiated by binding of normal human IgM to a hexosamine-containing lipooligosaccharide epitope(s) is augmented by strain-specific, properdin-binding-dependent alternative complement pathway activation.	lipid-linked oligosaccharides	99-118	complement factor properdin	Homo sapiens	163-172
19214747-1	2009	Mannosylphospho dolichol synthase (DPMS) is a critical enzyme in the biosynthesis of lipid-linked oligosaccharide (LLO; Glc(3)Man(9)GlcNAc(2)-PP-Dol), a pre-requisite for asparagine-linked (N-linked) protein glycosylation.	lipid-linked oligosaccharides	85-113	dolichyl-phosphate mannosyltransferase subunit 1, catalytic	Bos taurus	35-39
19214747-1	2009	Mannosylphospho dolichol synthase (DPMS) is a critical enzyme in the biosynthesis of lipid-linked oligosaccharide (LLO; Glc(3)Man(9)GlcNAc(2)-PP-Dol), a pre-requisite for asparagine-linked (N-linked) protein glycosylation.	lipid-linked oligosaccharides	115-118	dolichyl-phosphate mannosyltransferase subunit 1, catalytic	Bos taurus	35-39
3533914-2	1986	Insulin competition curves indicate that B4-2-1 cells, which transfer co-translationally to proteins an endoglycosidase H insensitive, truncated lipid-linked oligosaccharide, bind insulin with higher than normal affinity.	lipid-linked oligosaccharides	145-173	insulin	Homo sapiens	180-187
16664235-3	1985	The newly formed glycoproteins were hydrolyzed by endo-beta-N-acetylglucosaminidase H to oligosaccharides in the same size range as those released by dilute acid from the lipid-linked oligosaccharides formed during the pulse.	lipid-linked oligosaccharides	171-200	O-GlcNAcase	Homo sapiens	55-83
33010307-1	2020	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of oligosaccharide chains from lipid-linked oligosaccharides (LLO) to asparagine residues in polypeptide chains.	lipid-linked oligosaccharides	118-147	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
476828-1	1979	The glycosylation defect of Thy-1-mutant lymphomas of the class E complementation group has been identified as a block in the synthesis of the lipid-linked oligosaccharide precursor of the asparagine-linked oligosaccharides of glycoproteins.	lipid-linked oligosaccharides	143-171	Thy-1 cell surface antigen	Homo sapiens	28-33
6368538-6	1984	This result proves that ALG1 is the structural gene for the first mannosyltransferase in lipid-linked oligosaccharide assembly.	lipid-linked oligosaccharides	89-117	chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase	Saccharomyces cerevisiae S288C	24-28
7037780-3	1982	One of these mutants (alg1-1) has been characterized and found to be blocked in the assembly of the lipid-linked oligosaccharide precursor.	lipid-linked oligosaccharides	100-128	ALG11 alpha-1,2-mannosyltransferase	Homo sapiens	22-28
7037780-9	1982	These results indicate that the alg1-1 mutant is blocked specifically in the addition of the first mannose residue to the lipid-linked oligosaccharide precursor.	lipid-linked oligosaccharides	122-150	ALG11 alpha-1,2-mannosyltransferase	Homo sapiens	32-38
32684402-2	2021	Phosphorylcholine (ChoP) is expressed on lipooligosaccharides, and ChoP has phase variation, which is related to its adhesion to and invasion of epithelial cells in the upper airway.	lipid-linked oligosaccharides	41-61	DNA-damage inducible transcript 3	Mus musculus	19-23
33261211-2	2020	We recently showed that the immunopathological sequelae in Campylobacter jejuni-infected mice were due to Toll-like receptor (TLR)-4 dependent immune responses induced by bacterial lipooligosaccharide (LOS).	lipid-linked oligosaccharides	181-200	toll-like receptor 4	Mus musculus	106-132
33261211-2	2020	We recently showed that the immunopathological sequelae in Campylobacter jejuni-infected mice were due to Toll-like receptor (TLR)-4 dependent immune responses induced by bacterial lipooligosaccharide (LOS).	lipid-linked oligosaccharides	202-205	toll-like receptor 4	Mus musculus	106-132
33010307-1	2020	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of oligosaccharide chains from lipid-linked oligosaccharides (LLO) to asparagine residues in polypeptide chains.	lipid-linked oligosaccharides	118-147	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
33010307-1	2020	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of oligosaccharide chains from lipid-linked oligosaccharides (LLO) to asparagine residues in polypeptide chains.	lipid-linked oligosaccharides	149-152	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	0-25
33010307-1	2020	Oligosaccharyltransferase (OST) is a membrane-bound enzyme that catalyzes the transfer of oligosaccharide chains from lipid-linked oligosaccharides (LLO) to asparagine residues in polypeptide chains.	lipid-linked oligosaccharides	149-152	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	27-30
32753587-1	2020	Lipo-chitooligosaccharides (LCOs) are signaling molecules produced by rhizobial bacteria that trigger the nodulation process in legumes, and by some fungi that also establish symbiotic relationships with plants, notably the arbuscular and ecto mycorrhizal fungi.	lipid-linked oligosaccharides	28-32	high mobility group AT-hook 2	Homo sapiens	0-4
33090749-1	2020	Chemically, the Nod factors (NFs) are lipochitooligosaccharides, produced mainly by bacteria of the Rhizobium genus.	lipid-linked oligosaccharides	38-63	atrophin 1	Homo sapiens	16-19
30319665-2	2018	A successful symbiotic interaction relies on a molecular dialog between the plant and the bacteria, and generally involves rhizobial lipo-chitooligosaccharide signals called Nod factors (NFs).	lipid-linked oligosaccharides	133-158	atrophin 1	Homo sapiens	174-177
32443576-2	2020	The immunopathological sequelae of campylobacteriosis are caused by Toll-like Receptor-4 (TLR4)-dependent host immune responses, induced by bacterial lipooligosaccharide (LOS).	lipid-linked oligosaccharides	150-169	toll-like receptor 4	Mus musculus	90-94
32443576-2	2020	The immunopathological sequelae of campylobacteriosis are caused by Toll-like Receptor-4 (TLR4)-dependent host immune responses, induced by bacterial lipooligosaccharide (LOS).	lipid-linked oligosaccharides	171-174	toll-like receptor 4	Mus musculus	90-94
33654988-2	2019	A membrane-bound enzyme, oligosaccharyltransferase, catalyzes the transfer of an oligosaccharide chain from a sugar donor (lipid-linked oligosaccharide, LLO) to an asparagine residue in the consensus sequence, Asn-X-Ser/Thr (X   Pro), in proteins.	lipid-linked oligosaccharides	123-151	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	25-50
30181269-0	2018	Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.	lipid-linked oligosaccharides	94-122	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	10-17
30919527-3	2019	Herein, a novel molecular interaction between the human macrophage galactose-type lectin (MGL) and the lipooligosaccharide (LOS) of Escherichia coli strain R1 is described.	lipid-linked oligosaccharides	103-122	C-type lectin domain containing 10A	Homo sapiens	56-88
30919527-3	2019	Herein, a novel molecular interaction between the human macrophage galactose-type lectin (MGL) and the lipooligosaccharide (LOS) of Escherichia coli strain R1 is described.	lipid-linked oligosaccharides	103-122	C-type lectin domain containing 10A	Homo sapiens	90-93
29726994-7	2018	Treatment of gonococci infecting THP-1 monocytic cells reduced the levels of TNF-alpha probably owing to reduced numbers of bacteria and a lower level of expression of lipooligosaccharide.	lipid-linked oligosaccharides	168-187	tumor necrosis factor	Homo sapiens	77-86
30096783-2	2018	Recently, we demonstrated that free phosphocholine (PC) and PC-modified lipooligosaccharides (PC-LOS) from Haemophilus influenzae, an opportunistic pathogen of the upper and lower airways, function as unconventional nicotinic agonists and efficiently inhibit the ATP-induced release of monocytic IL-1beta.	lipid-linked oligosaccharides	72-92	interleukin 1 beta	Homo sapiens	296-304
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	lipid-linked oligosaccharides	32-60	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	149-174
29434478-5	2018	Internalization of bacteria or stimulation with lipooligosaccharide (LOS) specifically induced pyroptosis in MDMs and increased secretion of IL-1beta.	lipid-linked oligosaccharides	48-67	interleukin 1 beta	Homo sapiens	141-149
29434478-5	2018	Internalization of bacteria or stimulation with lipooligosaccharide (LOS) specifically induced pyroptosis in MDMs and increased secretion of IL-1beta.	lipid-linked oligosaccharides	69-72	interleukin 1 beta	Homo sapiens	141-149
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	lipid-linked oligosaccharides	32-60	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	176-179
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	lipid-linked oligosaccharides	62-65	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	149-174
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	lipid-linked oligosaccharides	62-65	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	176-179
28462843-2	2017	Here, we describe the discovery of a novel small molecular inhibitor chemotype for LgtC, a retaining alpha-1,4-galactosyltransferase involved in bacterial lipooligosaccharide biosynthesis.	lipid-linked oligosaccharides	155-174	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	101-132
29099761-2	2017	This review focuses on the role of carbohydrates of bacterial endotoxin (lipopolysaccharide, LPS, lipooligosaccharide, LOS, and lipid A), in the interaction with the host Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) complex.	lipid-linked oligosaccharides	98-117	toll like receptor 4	Homo sapiens	171-191
28922740-6	2017	Limited proteolysis experiments indicate that conformational changes of wildtype PglB that are induced by the binding of the lipid-linked oligosaccharide are altered by changes in the DGGK motif.	lipid-linked oligosaccharides	125-153	epiphycan	Homo sapiens	81-85
27435342-2	2016	Here we show that divergence of Lys11 and Nfr5 LysM receptor kinase paralogs of Lotus japonicus has affected their specificity for lipochitooligosaccharides (LCOs) decorations, while the innate capacity to recognize and induce a downstream signalling after perception of rhizobial LCOs (Nod factors) was maintained.	lipid-linked oligosaccharides	131-156	LYS11	Lotus japonicus	32-37
27670746-5	2016	We have found that this TLR4 antagonist is actually a lipooligosaccharide (LOS) instead of a LPS, and that it acts very effective, with a high inhibitory activity against triggering by the LPS-TLR4 system in the presence of a potent TLR4 agonist (E. coli LPS).	lipid-linked oligosaccharides	54-73	toll-like receptor 4	Mus musculus	189-192
27670746-5	2016	We have found that this TLR4 antagonist is actually a lipooligosaccharide (LOS) instead of a LPS, and that it acts very effective, with a high inhibitory activity against triggering by the LPS-TLR4 system in the presence of a potent TLR4 agonist (E. coli LPS).	lipid-linked oligosaccharides	54-73	toll-like receptor 4	Mus musculus	189-192
27670746-5	2016	We have found that this TLR4 antagonist is actually a lipooligosaccharide (LOS) instead of a LPS, and that it acts very effective, with a high inhibitory activity against triggering by the LPS-TLR4 system in the presence of a potent TLR4 agonist (E. coli LPS).	lipid-linked oligosaccharides	75-78	toll-like receptor 4	Mus musculus	189-192
27670746-5	2016	We have found that this TLR4 antagonist is actually a lipooligosaccharide (LOS) instead of a LPS, and that it acts very effective, with a high inhibitory activity against triggering by the LPS-TLR4 system in the presence of a potent TLR4 agonist (E. coli LPS).	lipid-linked oligosaccharides	75-78	toll-like receptor 4	Mus musculus	189-192
27435342-2	2016	Here we show that divergence of Lys11 and Nfr5 LysM receptor kinase paralogs of Lotus japonicus has affected their specificity for lipochitooligosaccharides (LCOs) decorations, while the innate capacity to recognize and induce a downstream signalling after perception of rhizobial LCOs (Nod factors) was maintained.	lipid-linked oligosaccharides	131-156	NFR5	Lotus japonicus	42-46
27476200-2	2016	At the first stage of rhizobial evolution, transformation of free-living diazotrophs (related to Rhodopseudomonas) to symbiotic N2-fixers (Bradyrhizobium) occurred due to the acquisition of the fix gene system, which is responsible for providing nitrogenase with electrons and reducing equivalents, as well as for oxygen-dependent regulation of nitrogenase synthesis in planta, and then of the nod genes responsible for the synthesis of the lipo- chito-oligosaccharide Nod factors, which induce root nodule development.	lipid-linked oligosaccharides	441-468	atrophin 1	Homo sapiens	394-397
27376801-0	2016	Opacity proteins of neisseria gonorrhoeae in lipooligosaccharide mutants lost ability to interact with neutrophil-restricted CEACAM3 (CD66d).	lipid-linked oligosaccharides	45-64	CEA cell adhesion molecule 3	Homo sapiens	125-132
27376801-0	2016	Opacity proteins of neisseria gonorrhoeae in lipooligosaccharide mutants lost ability to interact with neutrophil-restricted CEACAM3 (CD66d).	lipid-linked oligosaccharides	45-64	CEA cell adhesion molecule 3	Homo sapiens	134-139
27476200-2	2016	At the first stage of rhizobial evolution, transformation of free-living diazotrophs (related to Rhodopseudomonas) to symbiotic N2-fixers (Bradyrhizobium) occurred due to the acquisition of the fix gene system, which is responsible for providing nitrogenase with electrons and reducing equivalents, as well as for oxygen-dependent regulation of nitrogenase synthesis in planta, and then of the nod genes responsible for the synthesis of the lipo- chito-oligosaccharide Nod factors, which induce root nodule development.	lipid-linked oligosaccharides	441-468	atrophin 1	Homo sapiens	469-472
26716021-3	2015	For the first time, we here investigated the role of Toll-like receptor (TLR)-4, the main receptor for lipopolysaccharide and lipooligosaccharide of Gram-negative bacteria, in murine arcobacteriosis.	lipid-linked oligosaccharides	126-145	toll-like receptor 4	Mus musculus	53-79
26859677-7	2016	Studies of the role of the two known H. somni cytotoxins showed that viperin protein expression was induced by endotoxin (lipooligosaccharide) but not by IbpA, which mediates alveolar permeability and H. somni invasion.	lipid-linked oligosaccharides	122-141	radical S-adenosyl methionine domain containing 2	Bos taurus	69-76
25966638-4	2016	All affected patients were shown to have a novel homozygous splice variant NM_024740.2: c.1173+2T>A in the ALG9 gene, encoding alpha-1,2-mannosyltransferase, involved in the formation of the lipid-linked oligosaccharide precursor of N-glycosylation.	lipid-linked oligosaccharides	194-222	ALG9 alpha-1,2-mannosyltransferase	Homo sapiens	110-114
27891512-0	2016	A De-O-acylated Lipooligosaccharide-Based Adjuvant System Promotes Antibody and Th1-Type Immune Responses to H1N1 Pandemic Influenza Vaccine in Mice.	lipid-linked oligosaccharides	16-35	negative elongation factor complex member C/D, Th1l	Mus musculus	80-83
26335155-1	2016	ALG1-CDG (formerly CDG-Ik) is a subtype of congenital disorders of glycosylation (CDG) where the genetic defect disrupts the synthesis of the lipid-linked oligosaccharide precursor required for N-glycosylation.	lipid-linked oligosaccharides	142-170	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	0-4
26716022-3	2015	The aim of the present study was to investigate the immunopathological role of Toll-like Receptor-4, the receptor for lipopolysaccharide and lipooligosaccharide of Gram-negative bacteria, during murine A. butzleri infection.	lipid-linked oligosaccharides	141-160	toll-like receptor 4	Mus musculus	79-99
26716022-7	2015	Given that TLR-4-signaling is essential for A. butzleri-induced intestinal inflammation, we conclude that bacterial lipooligosaccharide or lipopolysaccharide compounds aggravate intestinal inflammation and may thus represent major virulence factors of Arcobacter.	lipid-linked oligosaccharides	116-135	toll-like receptor 4	Mus musculus	11-16
25418169-0	2014	Lipid-linked oligosaccharides in membranes sample conformations that facilitate binding to oligosaccharyltransferase.	lipid-linked oligosaccharides	0-29	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	91-116
25380763-6	2015	Here, we present the crystal structure of one such anti-carbohydrate HIV neutralizing antibody (2G12) in complex with the carbohydrate backbone of the lipooligosaccharide from Rhizobium radiobacter strain Rv3, which exhibits a chemical structure that naturally mimics the core high-mannose carbohydrate epitope of 2G12 on HIV-1 gp120.	lipid-linked oligosaccharides	151-170	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	328-333
25876268-4	2015	In particular C. jejuni infected infant mice harbouring a conventional microbiota and Interleukin-10-deficient mice rendered gnotobiotic by antibiotic treatment develop lipooligosaccharide mediated inflammation and specific T-cell responses--both key features of campylobacteriosis in humans.	lipid-linked oligosaccharides	169-188	interleukin 10	Mus musculus	86-100
25418169-1	2014	Lipid-linked oligosaccharides (LLOs) are the substrates of oligosaccharyltransferase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor asparagine of nascent proteins during the process of N-glycosylation.	lipid-linked oligosaccharides	0-29	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	59-84
25418169-1	2014	Lipid-linked oligosaccharides (LLOs) are the substrates of oligosaccharyltransferase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor asparagine of nascent proteins during the process of N-glycosylation.	lipid-linked oligosaccharides	0-29	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	86-89
25418169-1	2014	Lipid-linked oligosaccharides (LLOs) are the substrates of oligosaccharyltransferase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor asparagine of nascent proteins during the process of N-glycosylation.	lipid-linked oligosaccharides	31-35	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	59-84
25418169-1	2014	Lipid-linked oligosaccharides (LLOs) are the substrates of oligosaccharyltransferase (OST), the enzyme that catalyzes the en bloc transfer of the oligosaccharide onto the acceptor asparagine of nascent proteins during the process of N-glycosylation.	lipid-linked oligosaccharides	31-35	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	86-89
25453133-5	2014	By contrast, when these chitooligosaccharides are acylated (so-called lipochitooligosaccharides, LCOs) and further modified, they can act as Nod factors, the key signaling molecules that play an important role in the initiation of the legume-rhizobium symbiosis.	lipid-linked oligosaccharides	70-95	atrophin 1	Homo sapiens	141-144
25025465-4	2014	PAFR is a G-protein coupled receptor which can be engaged and activated by phosphorylcholine residues on the lipooligosaccharide (LOS) of nontypeable Haemophilus influenzae and the teichoic acid of Streptococcus pneumoniae as well as by its natural ligand, platelet activating factor (PAF).	lipid-linked oligosaccharides	109-128	platelet activating factor receptor	Homo sapiens	0-4
25154732-7	2014	LysM2 showed a change in folding upon nod factor binding, thus providing direct evidence that the LysM domain of NFR5 recognizes lipochitin oligosaccharides.	lipid-linked oligosaccharides	129-156	NFR5	Lotus japonicus	113-117
24442429-1	2014	In this article, we report that retreatment of human monocytic THP-1 cells and primary monocytes with pathogenic Neisseria or with purified lipooligosaccharides (LOS) after previous exposure to LOS induced immune tolerance, as evidenced by reduced TNF-alpha and IL-1beta cytokine expression.	lipid-linked oligosaccharides	140-160	interleukin 1 beta	Homo sapiens	262-270
24686069-4	2014	Purified lipooligosaccharide (LOS) containing lipid A devoid of the PEA modification and an lptA mutant of strain FA19 induced significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type LOS of the parent strain.	lipid-linked oligosaccharides	9-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
24686069-4	2014	Purified lipooligosaccharide (LOS) containing lipid A devoid of the PEA modification and an lptA mutant of strain FA19 induced significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type LOS of the parent strain.	lipid-linked oligosaccharides	9-28	toll like receptor 4	Homo sapiens	193-213
24686069-4	2014	Purified lipooligosaccharide (LOS) containing lipid A devoid of the PEA modification and an lptA mutant of strain FA19 induced significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type LOS of the parent strain.	lipid-linked oligosaccharides	9-28	toll like receptor 4	Homo sapiens	215-219
24686069-4	2014	Purified lipooligosaccharide (LOS) containing lipid A devoid of the PEA modification and an lptA mutant of strain FA19 induced significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type LOS of the parent strain.	lipid-linked oligosaccharides	30-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
24686069-4	2014	Purified lipooligosaccharide (LOS) containing lipid A devoid of the PEA modification and an lptA mutant of strain FA19 induced significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type LOS of the parent strain.	lipid-linked oligosaccharides	30-33	toll like receptor 4	Homo sapiens	193-213
24686069-4	2014	Purified lipooligosaccharide (LOS) containing lipid A devoid of the PEA modification and an lptA mutant of strain FA19 induced significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type LOS of the parent strain.	lipid-linked oligosaccharides	30-33	toll like receptor 4	Homo sapiens	215-219
24442429-1	2014	In this article, we report that retreatment of human monocytic THP-1 cells and primary monocytes with pathogenic Neisseria or with purified lipooligosaccharides (LOS) after previous exposure to LOS induced immune tolerance, as evidenced by reduced TNF-alpha and IL-1beta cytokine expression.	lipid-linked oligosaccharides	140-160	tumor necrosis factor	Homo sapiens	248-257
25036826-0	2014	Cloning and transcriptional expression of mouse mannosyltransferase IV/V cDNA, which is involved in the synthesis of lipid-linked oligosaccharides.	lipid-linked oligosaccharides	117-146	asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)	Mus musculus	48-72
23629657-2	2013	C. jejuni lipooligosaccharide (LOS) is a potent activator of Toll-like receptor (TLR) 4-mediated innate immunity.	lipid-linked oligosaccharides	10-29	toll like receptor 4	Homo sapiens	81-84
23519826-4	2013	NTHi express lipooligosaccharides that contain sialic acids, and may interact with Siglec-14, a sialic acid recognition protein on myeloid cells that serves as an activating signal transduction receptor.	lipid-linked oligosaccharides	13-33	sialic acid binding Ig like lectin 14	Homo sapiens	83-92
23750228-1	2013	Receptor(-like) kinases with Lysin Motif (LysM) domains in their extracellular region play crucial roles during plant interactions with microorganisms; e.g. Arabidopsis thaliana CERK1 activates innate immunity upon perception of fungal chitin/chitooligosaccharides, whereas Medicago truncatula NFP and LYK3 mediate signalling upon perception of bacterial lipo-chitooligosaccharides, termed Nod factors, during the establishment of mutualism with nitrogen-fixing rhizobia.	lipid-linked oligosaccharides	355-381	chitin elicitor receptor kinase 1	Arabidopsis thaliana	178-183
22144896-3	2011	While invasive and non-invasive isolates are both able to trigger the TLR4/MyD88 pathway in lipooligosaccharide (LOS)-dependant manner, we show that only non-invasive isolates were able to induce sustained NF-kappaB activity in infected epithelial cells.	lipid-linked oligosaccharides	92-111	toll like receptor 4	Homo sapiens	70-74
23333234-5	2013	METHODS: LPS or LOS was administered intravenously (IV) or intranasally (IN) 2h pre- or post-injection of IL-1beta.	lipid-linked oligosaccharides	16-19	interleukin 1 beta	Rattus norvegicus	106-114
23173866-8	2013	Lipo-oligosaccharide-specific binding of C. jejuni to Siglec-7 may be an initiating event in immune recognition and presentation, and lead to anti-GQ1b antibody production and the development of ocular weakness in GBS or MFS.	lipid-linked oligosaccharides	0-20	sialic acid binding Ig like lectin 7	Homo sapiens	54-62
22956764-3	2012	Although it has been widely proposed that Pmm2 deficiency depletes M1P, a precursor of GDP-mannose, and consequently suppresses lipid-linked oligosaccharide (LLO) levels needed for N-glycosylation, these deficiencies have not been demonstrated in patients or any animal model.	lipid-linked oligosaccharides	128-156	phosphomannomutase 2	Homo sapiens	42-46
22956764-3	2012	Although it has been widely proposed that Pmm2 deficiency depletes M1P, a precursor of GDP-mannose, and consequently suppresses lipid-linked oligosaccharide (LLO) levels needed for N-glycosylation, these deficiencies have not been demonstrated in patients or any animal model.	lipid-linked oligosaccharides	158-161	phosphomannomutase 2	Homo sapiens	42-46
22859506-1	2012	Lipochitin oligosaccharides called Nod factors function as primary rhizobial signal molecules triggering legumes to develop new plant organs: root nodules that host the bacteria as nitrogen-fixing bacteroids.	lipid-linked oligosaccharides	0-27	atrophin 1	Homo sapiens	35-38
22484951-0	2012	Synthesis of a spacer-linked derivative of heptopyranosyl(alpha1-3)heptopyranose expressed in lipooligosaccharide and lipopolysaccharide.	lipid-linked oligosaccharides	94-113	adrenoceptor alpha 1D	Homo sapiens	58-66
23411097-0	2013	Macrophage migration inhibitory factor is necessary for the lipo-oligosaccharide-induced response by modulation of Toll-like receptor 4 in monocytes from GBS patients.	lipid-linked oligosaccharides	60-80	macrophage migration inhibitory factor	Homo sapiens	0-38
23411097-0	2013	Macrophage migration inhibitory factor is necessary for the lipo-oligosaccharide-induced response by modulation of Toll-like receptor 4 in monocytes from GBS patients.	lipid-linked oligosaccharides	60-80	toll like receptor 4	Homo sapiens	115-135
22899857-3	2013	Synthesis of the lipid-linked oligosaccharide (LLO), which serves as the sugar donor for the N-glycosylation of secretory proteins, requires conversion of fructose-6-phosphate to mannose-6-phosphate via the phosphomannose isomerase (MPI) enzyme.	lipid-linked oligosaccharides	17-45	mannose phosphate isomerase	Homo sapiens	233-236
22899857-3	2013	Synthesis of the lipid-linked oligosaccharide (LLO), which serves as the sugar donor for the N-glycosylation of secretory proteins, requires conversion of fructose-6-phosphate to mannose-6-phosphate via the phosphomannose isomerase (MPI) enzyme.	lipid-linked oligosaccharides	47-50	mannose phosphate isomerase	Homo sapiens	233-236
22728124-8	2012	Compared to wild-type C. jejuni 81116, the lipooligosaccharide (LOS)-deficient 81116DeltawaaF mutant was much more susceptible to CATH-2.	lipid-linked oligosaccharides	43-62	cathelicidin-2	Gallus gallus	130-136
22728124-8	2012	Compared to wild-type C. jejuni 81116, the lipooligosaccharide (LOS)-deficient 81116DeltawaaF mutant was much more susceptible to CATH-2.	lipid-linked oligosaccharides	64-67	cathelicidin-2	Gallus gallus	130-136
22949553-2	2012	We have previously shown that phosphoethanolamine on the lipid A portion of lipooligosaccharide (LOS) plays an important role in Toll-like receptor 4 (TLR4) signaling.	lipid-linked oligosaccharides	76-95	toll like receptor 4	Homo sapiens	129-149
22949553-2	2012	We have previously shown that phosphoethanolamine on the lipid A portion of lipooligosaccharide (LOS) plays an important role in Toll-like receptor 4 (TLR4) signaling.	lipid-linked oligosaccharides	76-95	toll like receptor 4	Homo sapiens	151-155
22144896-3	2011	While invasive and non-invasive isolates are both able to trigger the TLR4/MyD88 pathway in lipooligosaccharide (LOS)-dependant manner, we show that only non-invasive isolates were able to induce sustained NF-kappaB activity in infected epithelial cells.	lipid-linked oligosaccharides	92-111	MYD88 innate immune signal transduction adaptor	Homo sapiens	75-80
22124985-0	2011	Reflectron MALDI TOF and MALDI TOF/TOF mass spectrometry reveal novel structural details of native lipooligosaccharides.	lipid-linked oligosaccharides	99-119	FEZ family zinc finger 2	Homo sapiens	17-20
22124985-0	2011	Reflectron MALDI TOF and MALDI TOF/TOF mass spectrometry reveal novel structural details of native lipooligosaccharides.	lipid-linked oligosaccharides	99-119	FEZ family zinc finger 2	Homo sapiens	31-34
22124985-0	2011	Reflectron MALDI TOF and MALDI TOF/TOF mass spectrometry reveal novel structural details of native lipooligosaccharides.	lipid-linked oligosaccharides	99-119	FEZ family zinc finger 2	Homo sapiens	31-34