PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9484239-8	1998	In transfected IMR-32 cells, the release of both the amyloid precursor protein and angiotensin converting enzyme was inhibited by batimastat, marimastat, and BB2116 with I50 values in the low micromolar range, while batimastat and BB2116 inhibited the release of both proteins from HUVECs.	BB 2116	158-164	amyloid beta precursor protein	Homo sapiens	53-78
18667434-4	2008	The ionomycin-induced Pyk2 phosphorylation was partially sensitive to AG1478, heparin, or the matrix-metalloproteinase inhibitor BB2116, and the ionomycin-induced EGF receptor phosphorylation was almost completely blocked by these inhibitors of extracellular transactivation.	BB 2116	129-135	protein tyrosine kinase 2 beta	Homo sapiens	22-26
11857410-5	2002	Here, we demonstrate that CD30 shedding from the cell line Karpas 299 could effectively be blocked by the hydroxamic acid-based metalloproteinase inhibitors BB-3644 (IC50 = 180 nM), BB-2116 (IC50 = 230 nM), BB-94 (batimastat, IC50 = 230 nM) and BB-2516 (marimastat, IC50 = 1 microM).	BB 2116	182-189	TNF receptor superfamily member 8	Homo sapiens	26-30
11116149-6	2001	BB2116 markedly inhibited ERK activation induced by AngII or the Ca(2+) ionophore without affecting the activation by EGF or PDGF.	BB 2116	0-6	mitogen-activated protein kinase 1	Homo sapiens	26-29
11116149-6	2001	BB2116 markedly inhibited ERK activation induced by AngII or the Ca(2+) ionophore without affecting the activation by EGF or PDGF.	BB 2116	0-6	angiotensinogen	Homo sapiens	52-57
11116149-10	2001	The findings that both BB2116 and AG1478 specifically inhibited activation of p38MAPK but not JNK by AngII support this hypothesis.	BB 2116	23-29	angiotensinogen	Homo sapiens	101-106
10626735-6	1999	Exogenous beta2m binds only to conformed HC, and protects them from cleavage as effectively as the MPase inhibitor BB-2116.	BB 2116	115-122	beta-2-microglobulin	Homo sapiens	10-16
11120787-4	2000	Moreover, CD30 shedding was blocked by the synthetic hydroxamic acid-based metalloproteinase inhibitor BB-2116 (IC(50), 230 nM) and the natural tissue inhibitor of metalloproteinases (TIMP)-3 (IC(50), 30 nM), but not by the matrix metalloproteinase inhibitors TIMP-1 and TIMP-2.	BB 2116	103-110	TNF receptor superfamily member 8	Homo sapiens	10-14
11120787-4	2000	Moreover, CD30 shedding was blocked by the synthetic hydroxamic acid-based metalloproteinase inhibitor BB-2116 (IC(50), 230 nM) and the natural tissue inhibitor of metalloproteinases (TIMP)-3 (IC(50), 30 nM), but not by the matrix metalloproteinase inhibitors TIMP-1 and TIMP-2.	BB 2116	103-110	TIMP metallopeptidase inhibitor 1	Homo sapiens	260-266
11120787-4	2000	Moreover, CD30 shedding was blocked by the synthetic hydroxamic acid-based metalloproteinase inhibitor BB-2116 (IC(50), 230 nM) and the natural tissue inhibitor of metalloproteinases (TIMP)-3 (IC(50), 30 nM), but not by the matrix metalloproteinase inhibitors TIMP-1 and TIMP-2.	BB 2116	103-110	TIMP metallopeptidase inhibitor 2	Homo sapiens	271-277
9743290-7	1998	In addition, the synthetic matrix metalloprotease inhibitor (MMPI) BB-2116, which blocks TNF-alpha shedding, inhibited proMMP-9 release in the co-cultures and from CM-stimulated monocytic cells.	BB 2116	67-74	tumor necrosis factor	Homo sapiens	89-98
9484239-8	1998	In transfected IMR-32 cells, the release of both the amyloid precursor protein and angiotensin converting enzyme was inhibited by batimastat, marimastat, and BB2116 with I50 values in the low micromolar range, while batimastat and BB2116 inhibited the release of both proteins from HUVECs.	BB 2116	158-164	angiotensin I converting enzyme	Homo sapiens	83-112
9484239-8	1998	In transfected IMR-32 cells, the release of both the amyloid precursor protein and angiotensin converting enzyme was inhibited by batimastat, marimastat, and BB2116 with I50 values in the low micromolar range, while batimastat and BB2116 inhibited the release of both proteins from HUVECs.	BB 2116	231-237	amyloid beta precursor protein	Homo sapiens	53-78
9484239-8	1998	In transfected IMR-32 cells, the release of both the amyloid precursor protein and angiotensin converting enzyme was inhibited by batimastat, marimastat, and BB2116 with I50 values in the low micromolar range, while batimastat and BB2116 inhibited the release of both proteins from HUVECs.	BB 2116	231-237	angiotensin I converting enzyme	Homo sapiens	83-112
9685994-6	1997	The complete inhibition of soluble TSH receptor shedding by the specific inhibitor BB-2116 indicated that the cleavage reaction is catalyzed probably at the cell surface by a matrix metalloprotease-like enzyme.	BB 2116	83-90	thyroid stimulating hormone receptor	Homo sapiens	35-47