PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22350545-3	2012	IVA is caused by an autosomal recessive deficiency of isovaleryl-CoA dehydrogenase (IVD) resulting in the accumulation of isovaleryl-CoA and its metabolites.	isovaleryl-coenzyme A	54-68	isovaleryl-CoA dehydrogenase	Homo sapiens	84-87
15930519-6	2005	Analyses of the assay conditions suggest a rationale for the lack of activity previously reported for some substrates (e.g. isovaleryl-CoA) for the (His)6pro-PAHX.	isovaleryl-coenzyme A	124-138	phytanoyl-CoA 2-hydroxylase	Homo sapiens	158-162
11592819-1	2001	Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric flavoenzyme, which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA and transfers electrons to the electron-transferring flavoprotein, and is a member of the acyl-CoA dehydrogenase (ACD) enzyme family.	isovaleryl-coenzyme A	102-116	isovaleryl-CoA dehydrogenase	Homo sapiens	0-28
7640268-1	1995	Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.	isovaleryl-coenzyme A	101-115	isovaleryl-CoA dehydrogenase	Homo sapiens	0-28
11386848-1	2001	Isovaleryl-CoA dehydrogenase (IVD) is a flavoenzyme, which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA in the leucine catabolism pathway and transfers electrons to the electron-transferring flavoprotein (ETF).	isovaleryl-coenzyme A	87-101	Butyryl-CoA dehydrogenase	Caenorhabditis elegans	0-28
11404023-1	2001	Isovaleryl-CoA dehydrogenase (IVD) is an intramitochondrial homotetrameric flavoenzyme that catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA in the leucine catabolism pathway.	isovaleryl-coenzyme A	120-134	isovaleryl-CoA dehydrogenase	Homo sapiens	0-28
11404023-1	2001	Isovaleryl-CoA dehydrogenase (IVD) is an intramitochondrial homotetrameric flavoenzyme that catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA in the leucine catabolism pathway.	isovaleryl-coenzyme A	120-134	isovaleryl-CoA dehydrogenase	Homo sapiens	30-33
10713113-1	2000	Isovaleric acidemia is a rare inborn error of metabolism caused by a deficiency of isovaleryl-CoA dehydrogenase (IVD), a nucleus-encoded, homotetrameric, mitochondrial flavoenzyme that catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.	isovaleryl-coenzyme A	83-97	isovaleryl-CoA dehydrogenase	Homo sapiens	113-116
9665741-1	1998	Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric mitochondrial flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.	isovaleryl-coenzyme A	115-129	isovaleryl-CoA dehydrogenase	Homo sapiens	0-28
9665741-1	1998	Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric mitochondrial flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.	isovaleryl-coenzyme A	115-129	isovaleryl-CoA dehydrogenase	Homo sapiens	30-33
7640268-1	1995	Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.	isovaleryl-coenzyme A	101-115	isovaleryl-CoA dehydrogenase	Homo sapiens	30-33
7642107-1	1995	Isovaleryl-CoA dehydrogenase (IVD) catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA in the leucine catabolism pathway.	isovaleryl-coenzyme A	63-77	isovaleryl-CoA dehydrogenase	Homo sapiens	0-28
7642107-1	1995	Isovaleryl-CoA dehydrogenase (IVD) catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA in the leucine catabolism pathway.	isovaleryl-coenzyme A	63-77	isovaleryl-CoA dehydrogenase	Homo sapiens	30-33
7802672-4	1994	The stability studies revealed no change in activity at 4 degrees C for up to 72 h, 25 degrees C for 4 h and at 37 degrees C for 1 h. The Km values of human ACGNAT for benzoyl CoA, salicyl CoA, isovaleryl CoA and octanoyl CoA were 57.9, 83.7, 124 and 198 mM, respectively, and the corresponding Vmax values were 17.1, 10.1, 7.64 and 3.3 mumol/min/mg protein.	isovaleryl-coenzyme A	194-208	glycine-N-acyltransferase	Homo sapiens	157-163
6930657-2	1980	It previously had been assumed that isovaleryl-CoA is dehydrogenated by n-butyryl-CoA dehydrogenase [butyryl-CoA:(acceptor) oxidoreductase, EC 1.3.99.2].	isovaleryl-coenzyme A	36-50	acyl-CoA dehydrogenase short chain	Rattus norvegicus	74-99
6930657-6	1980	These results unequivocally demonstrate that isovaleryl-CoA is oxidized by a specific isovaleryl-CoA dehydrogenase.	isovaleryl-coenzyme A	45-59	isovaleryl-CoA dehydrogenase	Rattus norvegicus	86-114
5276292-5	1971	It is concluded that isovaleryl CoA is dehydrogenated by a specific enzyme, isovaleryl CoA dehydrogenase, contrary to previous assumptions that it is dehydrogenated by green acyl CoA dehydrogenase.	isovaleryl-coenzyme A	21-35	isovaleryl-CoA dehydrogenase	Homo sapiens	76-104
33072933-1	2018	Isovaleric acidemia (IVA), an inborn error of leucine catabolism, is caused by mutations in the isovaleryl-CoA dehydrogenase (IVD) gene, resulting in the accumulation of derivatives of isovaleryl-CoA including isovaleryl (C5)-carnitine, the marker metabolite used for newborn screening (NBS).	isovaleryl-coenzyme A	96-110	isovaleryl-CoA dehydrogenase	Homo sapiens	126-129
26018748-2	2015	It is caused by a deficiency in isovaleryl-CoA dehydrogenase (IVD), a mitochondrial matrix enzyme that catalyzes the oxidation of isovaleryl-CoA to 3-methylcrotonyl-CoA.	isovaleryl-coenzyme A	32-46	isovaleryl-CoA dehydrogenase	Homo sapiens	62-65
25450250-1	2015	Isovaleryl-CoA dehydrogenase (IVD) catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA and the transfer of electrons to the electron transfer flavoprotein (ETF).	isovaleryl-coenzyme A	63-77	isovaleryl-CoA dehydrogenase	Homo sapiens	0-28
23643712-6	2014	Branched-chain amino acid related CoAs (isovaleryl-CoA, 3-methylcrotonyl-CoA, isobutyryl-CoA) showed less pronounced inhibition of NAGS whereas the dicarboxylic short-chain acyl-CoAs (methylmalonyl-CoA, succinyl-CoA, glutaryl-CoA) had the least inhibitory effect.	isovaleryl-coenzyme A	40-54	N-acetylglutamate synthase	Homo sapiens	131-135