PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1701408-6	1990	Recombination between a pBR322-derived donor plasmid and such a chromosomal platform results with high frequency in restoration of the bla gene and replacement of the chromosomal marker (SmR or KmR) by the insert of the donor plasmid.	pbr322	24-30	LY6/PLAUR domain containing 4	Homo sapiens	187-190
7548034-13	1995	In contrast, if poly(dAT) was added after irradiation, in addition to the elimination of nonspecific binding, a radiation dose-dependent increase in binding was revealed for both the kappa-Ig MAR and the hsp MAR (p < 0.001), but not for either of the pBR322 fragments.	pbr322	254-260	Dopamine transporter	Drosophila melanogaster	21-24
8234489-0	1993	Effects of plasmid pBR322 on respiratory and ATPase activities in Escherichia coli.	pbr322	19-25	ATPase	Escherichia coli	45-51
1652541-2	1991	The plasmids are derivatives of pBR322 which carry the Escherichia coli rpsL (strA) gene, known to confer a dominant streptomycin (Sm)-sensitivity phenotype to the host cell, and a copy of the IS1 transposable element.	pbr322	32-38	aminoglycoside-3''-phosphotransferase	Escherichia coli	78-82
9177996-2	1997	Previous studies have concentrated on transduction of pBR322 by P22 and P22HT, the high transducing mutant of P22.	pbr322	54-60	calcineurin like EF-hand protein 1	Homo sapiens	64-67
7937163-5	1994	Interestingly, we found that kin17 protein showed preferential binding to curved DNA from either pBR322 or synthetic oligonucleotides.	pbr322	97-103	Kin17 DNA and RNA binding protein	Mus musculus	29-34
8407920-2	1993	Both the Vp2 and Vp3 (Vp2/3) components of SV40 and mutant SV40(202T) bound either SV40 or pBR322 DNA equally well.	pbr322	91-97	hypothetical protein	Macaca mulatta polyomavirus 1	9-12
8407920-2	1993	Both the Vp2 and Vp3 (Vp2/3) components of SV40 and mutant SV40(202T) bound either SV40 or pBR322 DNA equally well.	pbr322	91-97	hypothetical protein	Macaca mulatta polyomavirus 1	17-20
8407920-2	1993	Both the Vp2 and Vp3 (Vp2/3) components of SV40 and mutant SV40(202T) bound either SV40 or pBR322 DNA equally well.	pbr322	91-97	hypothetical protein	Macaca mulatta polyomavirus 1	22-27
2531108-0	1989	Negative effect of a cis-acting pBR322 element on adenovirus E1a gene expression.	pbr322	32-38	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	61-64
34202624-6	2021	DNA interaction studies of the Co(III) complexes with plasmid pBR322 using spectrophotometric titration methods revealed that the interaction between Complex (1) or (2) and DNA suggested an electrostatic and intercalative mode of binding, respectively.	pbr322	62-68	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	31-38
2559144-3	1989	The affinity for this region is perpetuated in pVS76, a clone of RP1 PstI-C in pBR322.	pbr322	79-85	RP1 axonemal microtubule associated	Homo sapiens	65-68
2559144-3	1989	The affinity for this region is perpetuated in pVS76, a clone of RP1 PstI-C in pBR322.	pbr322	79-85	serine peptidase inhibitor Kazal type 1	Homo sapiens	69-73
2557897-4	1989	Under standard reaction conditions, relaxation of supercoiled pBR322 by p180 was highly processive, while p170 performed the same reaction in a distributive manner.	pbr322	62-68	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	72-76
2714653-2	1989	On the basis of stability analysis of pBR322 derivatives comprising the modified region of the TcR gene, we deduced that it is the nucleotide sequence localized in the region of the HindIII site that causes destabilization of the plasmid and not the TcR gene product or active transcription of this region.	pbr322	38-44	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	95-98
2714653-2	1989	On the basis of stability analysis of pBR322 derivatives comprising the modified region of the TcR gene, we deduced that it is the nucleotide sequence localized in the region of the HindIII site that causes destabilization of the plasmid and not the TcR gene product or active transcription of this region.	pbr322	38-44	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	250-253
3308847-4	1987	The insertion of sop+ from the F plasmid or parB+ from the R1 plasmid reduced the loss frequency by a factor of 10(3) for the pBR322 derivative and by at least a factor of 10(2) for the mini-R1 plasmid.	pbr322	126-132	transcriptional regulators	Escherichia coli	44-48
3170549-2	1988	Methylated DNA-binding protein (MDBP) from human placenta has a high affinity for a site in pBR322 (pB site 1) when that site is methylated at its CpG dinucleotides.	pbr322	92-98	zinc finger protein 763	Homo sapiens	11-30
2424452-2	1986	Both fractions stimulated the pBR322-directed synthesis of the amp gene product, pre-beta-lactamase, in the in vitro system.	pbr322	30-36	beta-lactamase	Escherichia coli	85-99
3108235-1	1987	Oligonucleotide-directed mutagenesis of the beta-lactamase gene, bla, on pBR322 was used to change the codon for the active-site serine 70, AGC, to CGC, coding for arginine.	pbr322	73-79	beta-lactamase	Escherichia coli	44-58
3108235-1	1987	Oligonucleotide-directed mutagenesis of the beta-lactamase gene, bla, on pBR322 was used to change the codon for the active-site serine 70, AGC, to CGC, coding for arginine.	pbr322	73-79	beta-lactamase	Escherichia coli	65-68
3040690-1	1987	The structural genes of ADPglucose pyrophosphorylase (glgC) and glycogen synthase (glgA) from Salmonella typhimurium LT2 were cloned on a 5.8-kilobase-pair insert in the SalI site of pBR322.	pbr322	183-189	starch synthase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	64-81
3040690-1	1987	The structural genes of ADPglucose pyrophosphorylase (glgC) and glycogen synthase (glgA) from Salmonella typhimurium LT2 were cloned on a 5.8-kilobase-pair insert in the SalI site of pBR322.	pbr322	183-189	starch synthase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	83-87
3029390-7	1986	IncG incompatibility is exhibited by pBR322 derivatives carrying the sopB gene alone.	pbr322	37-43	hypothetical protein	Escherichia coli	69-73
2423846-1	1986	The concentration of plasmid pBR322, of its replication inhibitor, RNAI, and preprimer, RNAII, were observed in E. coli as functions of the bacterial growth rate.	pbr322	29-35	D616_p116002	Escherichia coli	67-71
2985793-2	1985	This cDNA was cloned either after insertion into a plasmid-primed synthesis system or after insertion into the PstI site of pBR322.	pbr322	124-130	serine peptidase inhibitor Kazal type 1	Homo sapiens	111-115
3004933-1	1985	A recombinant plasmid containing the human proenkephalin gene ligated to pBR322 was introduced into a mouse pituitary cell line (AtT-20D16v) that normally expresses pro-opiomelanocortin but not proenkephalin.	pbr322	73-79	proenkephalin	Homo sapiens	43-56
2413453-2	1985	The cDNA, cloned in pBR322 by use of oligo(dG) X oligo(dC) tails, yields two Pst I fragments of 250 and 600 base pairs (bp).	pbr322	20-26	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	77-80
6374659-7	1984	However, expression in pBR322 was more efficient in one orientation than in the other, suggesting that one or both of the bla gene promoters contributed to skc expression.	pbr322	23-29	beta-lactamase	Escherichia coli	122-125
6093790-1	1984	Using a highly purified preparation of glycine methyltransferase mRNA, double-stranded cDNA was synthesized and inserted into the PstI site of pBR322.	pbr322	143-149	glycine N-methyltransferase	Rattus norvegicus	39-64
6139278-1	1983	A cDNA library was constructed in pBR322 from mRNA encoding an anti-GAT (Glu60 Ala30 Tyr10) monoclonal antibody kappa chain.	pbr322	34-40	glycine-N-acyltransferase	Mus musculus	68-71
24177744-3	1984	However, the size of the rbcL polypeptide synthesized in minicells appeared to be dependent on the orientation of the S9 fragment in pBR322.	pbr322	133-139	RuBisCO large subunit	Nicotiana tabacum	25-29
6365904-1	1984	A derivative of pBR322 has been constructed that contains both a unique EcoRI restriction site right at the beginning of the signal codons of the beta-lactamase (bla) gene and a unique BstEII site just at the end of the bla signal codons.	pbr322	16-22	beta-lactamase	Escherichia coli	162-165
6365904-1	1984	A derivative of pBR322 has been constructed that contains both a unique EcoRI restriction site right at the beginning of the signal codons of the beta-lactamase (bla) gene and a unique BstEII site just at the end of the bla signal codons.	pbr322	16-22	beta-lactamase	Escherichia coli	220-223
6687522-3	1983	The cDNA was cloned into the PstI site of pBR322 by G-C tailing.	pbr322	42-48	serine peptidase inhibitor, Kazal type 1-like	Rattus norvegicus	29-33
27475779-7	2016	Complexes (1-3) exhibit a good binding propensity to bovine serum albumin (BSA) and gel electrophoresis assay demonstrated that the complexes (1-3) promote the cleavage of the pBR322 DNA in the presence of 3-mercaptopropionic acid (MPA) and cleavage process was found to proceed by singlet oxygen cleavage mechanism.	pbr322	176-182	albumin	Homo sapiens	60-73
6329701-1	1982	pED806 , a pBR322 derivative carrying the origin of transfer ( oriT ) of F, was rapidly lost from cells carrying an F tra+ plasmid.	pbr322	11-17	T cell receptor alpha locus	Homo sapiens	52-55
386338-1	1979	Entrapment of pBR322 DNA within liposomes was demonstrated by (i) its comigration with liposomes on Sepharose 4B columns, (ii) resistance of its biological activity to DNase digestion, and (iii) identification of plasmid DNA on agarose gels after lipid extraction.	pbr322	14-20	colicin E8	Escherichia coli	168-173
26882290-9	2016	All the experimental studies showed that Pc1, Pc2 and Pc3 compounds bind to CT-DNA via minor groove binding, cleave of supercoiled pBR322 DNA via photocleavage pathway, inhibit topoisomerase I and have remarkable superoxide radical scavenging activities.	pbr322	131-137	proprotein convertase subtilisin/kexin type 1	Bos taurus	41-44
26882290-9	2016	All the experimental studies showed that Pc1, Pc2 and Pc3 compounds bind to CT-DNA via minor groove binding, cleave of supercoiled pBR322 DNA via photocleavage pathway, inhibit topoisomerase I and have remarkable superoxide radical scavenging activities.	pbr322	131-137	proprotein convertase subtilisin/kexin type 2	Bos taurus	46-49
26882290-9	2016	All the experimental studies showed that Pc1, Pc2 and Pc3 compounds bind to CT-DNA via minor groove binding, cleave of supercoiled pBR322 DNA via photocleavage pathway, inhibit topoisomerase I and have remarkable superoxide radical scavenging activities.	pbr322	131-137	proprotein convertase subtilisin/kexin type 1	Bos taurus	54-57
19486643-4	2009	This defect was complemented by provision of either pfkA or pfkB on pBR322.	pbr322	68-74	phosphofructokinase, liver, B-type	Mus musculus	60-64
16139359-4	2006	A rop-containing derivative of pBAD24 (called pBAD322) having the copy number of pBR322 is reported together with derivatives of pBAD322 that encode resistance to chloramphenicol, kanamycin, tetracycline, spectinomycin/streptomycin, gentamycin, or trimethoprim in place of ampicillin.	pbr322	81-87	regulatory protein Rop	Escherichia coli	2-5
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	36-42	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	5-9
11225590-9	2001	In comparison with a control group injected with pBR322, they exhibited moderate protection, in terms of prolonged survival, against MK16/1/IIIABC challenge (P < 0.03).	pbr322	49-55	potassium voltage-gated channel subfamily A member 1	Homo sapiens	133-139
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	36-42	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	75-79
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	36-42	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	61-65
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	119-125	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	5-9
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	36-42	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	67-71
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	119-125	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	61-65
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	119-125	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	67-71
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	36-42	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	75-79
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	119-125	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	75-79
10219090-3	1999	When arg4 sequences are placed in a pBR322-derived insert at HIS4 (his4 :: arg4 ), the presence of strong DSB sites in pBR322 sequences leads to an almost complete loss of breaks from the insert-borne arg4 promoter region.	pbr322	119-125	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	75-79
10219090-6	1999	Elimination of pBR322 sequences restored DSBs to the insert-borne arg4 promoter region and also restored the meiotic induction of MNase hypersensitivity.	pbr322	15-21	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	66-70