PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15473551-1	2004	The effect of a BTEX mixture on the biodegradation of methyl tert-butyl ether (MTBE) and its degradation intermediate, tert-butyl alcohol (TBA) was investigated in the pure bacterial culture UC1, which has been identified to be a strain of the known MTBE-degrader PM1 based on greater than 99% 16S rDNA similarity.	methyl tert-butyl ether	54-77	transmembrane protein 11	Homo sapiens	264-267
15473551-1	2004	The effect of a BTEX mixture on the biodegradation of methyl tert-butyl ether (MTBE) and its degradation intermediate, tert-butyl alcohol (TBA) was investigated in the pure bacterial culture UC1, which has been identified to be a strain of the known MTBE-degrader PM1 based on greater than 99% 16S rDNA similarity.	methyl tert-butyl ether	79-83	transmembrane protein 11	Homo sapiens	264-267
12919726-4	2003	Thus, kinetic parameters were determined for the hydroxylation of five substrates of diverse chemical structures known to be selective for cytochrome P450 2A6: methyl tert-butyl ether (MTBE), nicotine, coumarin, N-nitrosobenzylmethylamine (NBzMA), and N-nitrosodiethylamine (NDEA).	methyl tert-butyl ether	160-183	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	139-158
12948530-1	2003	The aim of this study was to obtain information about the degradation of t-butyl methyl ether (MTBE; (CH(3))(3)C-O-CH(3)) in atmospheric water droplets (rain, clouds, fog).	methyl tert-butyl ether	73-93	zinc finger protein, FOG family member 1	Homo sapiens	167-170
12919726-4	2003	Thus, kinetic parameters were determined for the hydroxylation of five substrates of diverse chemical structures known to be selective for cytochrome P450 2A6: methyl tert-butyl ether (MTBE), nicotine, coumarin, N-nitrosobenzylmethylamine (NBzMA), and N-nitrosodiethylamine (NDEA).	methyl tert-butyl ether	185-189	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	139-158
10670732-2	1999	Extraction of the internal standard, M8 and NFV from the plasma buffered at pH 9.5 was achieved by a liquid-liquid extraction with a mixture of methyl-tert.-butyl ether and hexane.	methyl tert-butyl ether	144-168	prion locus lncRNA, testis expressed	Homo sapiens	37-47
10502501-0	1999	Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: identification of CYP2A6 as a major catalyst.	methyl tert-butyl ether	14-37	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	161-167
10319275-17	1999	We conclude that 2-5A and PKR are not only biomarkers for viral induction of CFS, but biomarkers to other stressors that include MTBE and Benzene.	methyl tert-butyl ether	129-133	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	26-29
10329508-0	1999	Evaluation of the in vivo interaction of methyl tert-butyl ether with alpha2u-globulin in male F-344 rats.	methyl tert-butyl ether	41-64	alpha2u globulin	Rattus norvegicus	70-86
9463929-0	1997	Risk characterization of methyl tertiary butyl ether (MTBE) in tap water.	methyl tert-butyl ether	25-52	nuclear RNA export factor 1	Homo sapiens	63-66
9463929-0	1997	Risk characterization of methyl tertiary butyl ether (MTBE) in tap water.	methyl tert-butyl ether	54-58	nuclear RNA export factor 1	Homo sapiens	63-66
9306134-14	1997	NF-kappa B was examined as one of the many molecular mechanisms for mediating cell death by MTBE and benzene.	methyl tert-butyl ether	92-96	nuclear factor kappa B subunit 1	Homo sapiens	0-10
9144447-0	1997	Methyl tert-butyl ether causes alpha2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats.	methyl tert-butyl ether	0-23	alpha2u globulin	Rattus norvegicus	31-47
33334519-0	2021	Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo.	methyl tert-butyl ether	0-27	apolipoprotein E	Mus musculus	117-121
1385560-6	1992	CBP was isolated from proteins precipitated from bile by CaCl2, as well as from the calcium bilirubinate shells of cholesterol gallstones, by extraction successively with methyl-t-butyl ether, methanol, and Na2EDTA, followed by Sephadex G-25 chromatography and two-stage preparative SDS-PAGE.	methyl tert-butyl ether	171-191	CREB binding protein	Homo sapiens	0-3
34121485-0	2021	DNA polymerase beta may be involved in protecting human bronchial epithelial cells from the toxic effects induced by methyl tert-butyl ether exposure.	methyl tert-butyl ether	117-140	DNA polymerase beta	Homo sapiens	0-19
34121485-11	2021	DNA polymerase beta may be involved in protecting 16HBE cells from the toxic effects induced by MTBE exposure.	methyl tert-butyl ether	96-100	DNA polymerase beta	Homo sapiens	0-19
16867619-2	1986	The isomers of clomiphene, in addition to metabolites, are extracted from plasma with tert-butyl methyl ether (MTB).	methyl tert-butyl ether	86-109	metallothionein 1J, pseudogene	Homo sapiens	111-114
32992562-1	2020	Methanol/Methyl Tert-butyl Ether (MTBE) Separation via Pervaporation: A Comprehensive Review.	methyl tert-butyl ether	34-38	telomerase reverse transcriptase	Homo sapiens	16-20
32992562-2	2020	Methyl Tert-butyl Ether (MTBE) remains the most popular fuel additive to improve fuel performance and reduce the emission of hazardous components.	methyl tert-butyl ether	25-29	telomerase reverse transcriptase	Homo sapiens	7-11
32326643-1	2020	It is of great significance to separate hazardous methyl tert-butyl ether (MTBE) from water in terms of environmental protection and human health.	methyl tert-butyl ether	75-79	telomerase reverse transcriptase	Homo sapiens	57-61
30090498-0	2017	SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells.	methyl tert-butyl ether	45-68	sirtuin 1	Mus musculus	0-5
31053351-2	2019	SARM residues were extracted from urine (200 muL) with tert-butyl methyl ether (TBME) without further clean-up and analysed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS).	methyl tert-butyl ether	55-78	sterile alpha and TIR motif containing 1	Homo sapiens	0-4
31053351-2	2019	SARM residues were extracted from urine (200 muL) with tert-butyl methyl ether (TBME) without further clean-up and analysed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS).	methyl tert-butyl ether	80-84	sterile alpha and TIR motif containing 1	Homo sapiens	0-4
29139569-4	2018	However, the best result was obtained in the mixture [BMIM][PF6 ]:TBME (1:1 v/v) at 50 C. Enzyme activity and selectivity in [BMIM][PF6 ]:TBME (1:1 v/v) was slightly higher in than in conventional organic solvents (for example, TBME), and in this condition, good activity and enantioselectivity were associated with unique properties of ionic liquid such as hydrophobicity and high polarity.	methyl tert-butyl ether	66-70	sperm associated antigen 17	Homo sapiens	60-63
29139569-4	2018	However, the best result was obtained in the mixture [BMIM][PF6 ]:TBME (1:1 v/v) at 50 C. Enzyme activity and selectivity in [BMIM][PF6 ]:TBME (1:1 v/v) was slightly higher in than in conventional organic solvents (for example, TBME), and in this condition, good activity and enantioselectivity were associated with unique properties of ionic liquid such as hydrophobicity and high polarity.	methyl tert-butyl ether	66-70	sperm associated antigen 17	Homo sapiens	132-135
29139569-4	2018	However, the best result was obtained in the mixture [BMIM][PF6 ]:TBME (1:1 v/v) at 50 C. Enzyme activity and selectivity in [BMIM][PF6 ]:TBME (1:1 v/v) was slightly higher in than in conventional organic solvents (for example, TBME), and in this condition, good activity and enantioselectivity were associated with unique properties of ionic liquid such as hydrophobicity and high polarity.	methyl tert-butyl ether	138-142	sperm associated antigen 17	Homo sapiens	60-63
29139569-4	2018	However, the best result was obtained in the mixture [BMIM][PF6 ]:TBME (1:1 v/v) at 50 C. Enzyme activity and selectivity in [BMIM][PF6 ]:TBME (1:1 v/v) was slightly higher in than in conventional organic solvents (for example, TBME), and in this condition, good activity and enantioselectivity were associated with unique properties of ionic liquid such as hydrophobicity and high polarity.	methyl tert-butyl ether	138-142	sperm associated antigen 17	Homo sapiens	132-135
29139569-4	2018	However, the best result was obtained in the mixture [BMIM][PF6 ]:TBME (1:1 v/v) at 50 C. Enzyme activity and selectivity in [BMIM][PF6 ]:TBME (1:1 v/v) was slightly higher in than in conventional organic solvents (for example, TBME), and in this condition, good activity and enantioselectivity were associated with unique properties of ionic liquid such as hydrophobicity and high polarity.	methyl tert-butyl ether	138-142	sperm associated antigen 17	Homo sapiens	60-63
29139569-4	2018	However, the best result was obtained in the mixture [BMIM][PF6 ]:TBME (1:1 v/v) at 50 C. Enzyme activity and selectivity in [BMIM][PF6 ]:TBME (1:1 v/v) was slightly higher in than in conventional organic solvents (for example, TBME), and in this condition, good activity and enantioselectivity were associated with unique properties of ionic liquid such as hydrophobicity and high polarity.	methyl tert-butyl ether	138-142	sperm associated antigen 17	Homo sapiens	132-135
28917599-7	2017	In nano-LC, the CSP was stressed under the use of strong organic solvents such as ethyl acetate, acetone and methyl t-butyl ether (MTBE).	methyl tert-butyl ether	109-129	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	16-19
28917599-7	2017	In nano-LC, the CSP was stressed under the use of strong organic solvents such as ethyl acetate, acetone and methyl t-butyl ether (MTBE).	methyl tert-butyl ether	131-135	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	16-19
29631252-2	2018	By virtue of the high resolution, high speed of HPLC and the accurate mass measurement of FT-ICR MS and QTOF MS2, 31 metabolites in methyl tert-butyl ether (MTBE) layer were detected, and the structures of 16 metabolites were identified.	methyl tert-butyl ether	157-161	MS2	Homo sapiens	109-112
20387635-1	2009	The main goal of this work was investigation of the effect of methyl tertbutyl ether, ecologically dangerous chemical compound, on the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB-3) and vascular endothelial growth factor (VEGF) mRNA in different rat organs.	methyl tert-butyl ether	62-84	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Rattus norvegicus	149-203
24399255-6	2014	These results suggested that TBME is able to induce anticancer effects on both lung and breast cancer cell lines through the modulation of Bcl-2 family proteins.	methyl tert-butyl ether	29-33	BCL2 apoptosis regulator	Homo sapiens	139-144
31986752-1	2014	Upon slow evaporation of a 1:1 diastereoisomeric mixture of Boc-(L-Phe-L-Oxd)2 -OBn (1; Boc=tert-butyloxycarbonyl; L-Oxd=trans-(4S,5R)-4-carboxy 5-methyloxazolidin-2-one, Bn=benzyloxycarbonyl) and Boc-L-Phe-L-Oxd-D-Phe-L-Oxd-OBn (2) in methyl tert-butyl ether, single crystals suitable for an X-ray diffraction study were obtained.	methyl tert-butyl ether	236-259	BOC cell adhesion associated, oncogene regulated	Homo sapiens	60-63
21915685-0	2012	Biotransformation of methyl tert-butyl ether by human cytochrome P450 2A6.	methyl tert-butyl ether	21-44	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	54-73
20801485-8	2010	For example, in a 24-h extraction with acetonitrile of FTS-amended soil, >5wt.% FTOH was produced compared to <0.04wt.% in either ethyl acetate or MTBE.	methyl tert-butyl ether	153-157	AKT interacting protein	Homo sapiens	55-58
20387635-6	2009	Results of this investigation clearly demonstrated that methyl tertbutyl ether affects the expression of PFKFB-3, a key regulatory enzyme of glycolysis, as well as VEGF, very important factor of angiogenesis, in an organ-specific and dose-dependent manner.	methyl tert-butyl ether	56-78	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Rattus norvegicus	105-112
26193678-0	2015	Interaction of insulin with methyl tert-butyl ether promotes molten globule-like state and production of reactive oxygen species.	methyl tert-butyl ether	28-51	insulin	Homo sapiens	15-22
20162403-3	2009	PAR-5359 was twice extracted from rat plasma using methyl tert-butyl ether at neutral pH.	methyl tert-butyl ether	51-74	plasminogen activator, urokinase receptor	Rattus norvegicus	0-3
20387635-1	2009	The main goal of this work was investigation of the effect of methyl tertbutyl ether, ecologically dangerous chemical compound, on the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB-3) and vascular endothelial growth factor (VEGF) mRNA in different rat organs.	methyl tert-butyl ether	62-84	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Rattus norvegicus	205-212
20387635-6	2009	Results of this investigation clearly demonstrated that methyl tertbutyl ether affects the expression of PFKFB-3, a key regulatory enzyme of glycolysis, as well as VEGF, very important factor of angiogenesis, in an organ-specific and dose-dependent manner.	methyl tert-butyl ether	56-78	vascular endothelial growth factor A	Rattus norvegicus	164-168
20387635-1	2009	The main goal of this work was investigation of the effect of methyl tertbutyl ether, ecologically dangerous chemical compound, on the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB-3) and vascular endothelial growth factor (VEGF) mRNA in different rat organs.	methyl tert-butyl ether	62-84	vascular endothelial growth factor A	Rattus norvegicus	218-252
20387635-1	2009	The main goal of this work was investigation of the effect of methyl tertbutyl ether, ecologically dangerous chemical compound, on the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB-3) and vascular endothelial growth factor (VEGF) mRNA in different rat organs.	methyl tert-butyl ether	62-84	vascular endothelial growth factor A	Rattus norvegicus	254-258
20387635-3	2009	In this study we have shown that PFKFB-3 and VEGF mRNA expression in the liver, lung, and heart changes in rats, treated with methyl tertbutyl ether for two months, in organ-specific manner.	methyl tert-butyl ether	126-148	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Rattus norvegicus	33-40
20387635-3	2009	In this study we have shown that PFKFB-3 and VEGF mRNA expression in the liver, lung, and heart changes in rats, treated with methyl tertbutyl ether for two months, in organ-specific manner.	methyl tert-butyl ether	126-148	vascular endothelial growth factor A	Rattus norvegicus	45-49
20387635-4	2009	Expression of alternative splice variants of PFKFB-3 mRNA as well as VEGF mRNA also changes in organ-specific manner in rats, treated with methyl tertbutyl ether.	methyl tert-butyl ether	139-161	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Rattus norvegicus	45-52
20387635-4	2009	Expression of alternative splice variants of PFKFB-3 mRNA as well as VEGF mRNA also changes in organ-specific manner in rats, treated with methyl tertbutyl ether.	methyl tert-butyl ether	139-161	vascular endothelial growth factor A	Rattus norvegicus	69-73
20387635-5	2009	The effect of methyl tertbutyl ether on the expression of PFKFB-3 and VEGF mRNA and its alternative splice variants is dose-dependent.	methyl tert-butyl ether	14-36	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Rattus norvegicus	58-65
20387635-5	2009	The effect of methyl tertbutyl ether on the expression of PFKFB-3 and VEGF mRNA and its alternative splice variants is dose-dependent.	methyl tert-butyl ether	14-36	vascular endothelial growth factor A	Rattus norvegicus	70-74
19344668-0	2009	gamma-Aminobutyric acid(A) (GABA(A)) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of methyl tert-butyl ether (MTBE)-induced impairment of spatial memory.	methyl tert-butyl ether	115-138	mitogen activated protein kinase 3	Rattus norvegicus	56-62
19036514-0	2009	The application of silicalite-1/fly ash cenosphere (S/FAC) zeolite composite for the adsorption of methyl tert-butyl ether (MTBE).	methyl tert-butyl ether	99-122	failed axon connections	Drosophila melanogaster	54-57
19036514-0	2009	The application of silicalite-1/fly ash cenosphere (S/FAC) zeolite composite for the adsorption of methyl tert-butyl ether (MTBE).	methyl tert-butyl ether	124-128	failed axon connections	Drosophila melanogaster	54-57
19036514-1	2009	Silicalite-1/fly ash cenosphere (S/FAC) zeolite composite has been applied for batch adsorption of methyl tert-butyl ether (MTBE) from water systems.	methyl tert-butyl ether	99-122	failed axon connections	Drosophila melanogaster	35-38
19036514-1	2009	Silicalite-1/fly ash cenosphere (S/FAC) zeolite composite has been applied for batch adsorption of methyl tert-butyl ether (MTBE) from water systems.	methyl tert-butyl ether	124-128	failed axon connections	Drosophila melanogaster	35-38
19344668-0	2009	gamma-Aminobutyric acid(A) (GABA(A)) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of methyl tert-butyl ether (MTBE)-induced impairment of spatial memory.	methyl tert-butyl ether	140-144	mitogen activated protein kinase 3	Rattus norvegicus	56-62
19696944-6	2008	Moreover, the effect of temperature on ETBE (tert-butylethyl ether) and MTBE (tert-butylmethyl ether) conversions was verified.	methyl tert-butyl ether	72-76	telomerase reverse transcriptase	Homo sapiens	78-82
18492345-3	2008	This method quantifies trace levels of methyl tertiary-butyl ether, ethyl tertiary-butyl ether, di-isopropyl ether, and tertiary-amyl methyl ether in tap water.	methyl tert-butyl ether	39-66	nuclear RNA export factor 1	Homo sapiens	150-153
18492345-7	2008	Methyl tertiary-butyl ether was detected in samples of tap water taken from geographically diverse regions of the United States.	methyl tert-butyl ether	0-27	nuclear RNA export factor 1	Homo sapiens	55-58
17221932-3	2007	TXL was extracted by a liquid-liquid extraction with tert-butylmethyl ether.	methyl tert-butyl ether	53-75	thioredoxin like 1	Homo sapiens	0-3
15607170-1	2005	The fundamentals of the Fenton reagent-based degradation of low concentrations of methyl tert-butyl ether (MTBE) in batch reactors under initially anaerobic conditions are discussed in this work.	methyl tert-butyl ether	107-111	telomerase reverse transcriptase	Homo sapiens	89-93