PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15896707-0 2005 Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. fucoxanthin 0-11 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 87-91 15896707-7 2005 In the fucoxanthin-fed mice, WAT weight significantly decreased and UCP1 was clearly expressed in the WAT, while there was no difference in WAT weight and little expression of UCP1 in the glycolipids-fed mice. fucoxanthin 7-18 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 68-72 15896707-8 2005 This result indicates that fucoxanthin upregulates the expression of UCP1 in WAT, which may contribute to reducing WAT weight. fucoxanthin 27-38 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 69-73 32045601-6 2020 Estradiol increased the hepatic expression of miR-33 and inhibited that of miR-34a and miR-21, leading to adjusting the gene expression and the protein level of their targets, sterol regulatory element-binding proteins-1c (SREBP-1c), fatty acid synthase (FASN), high mobility group (HMG) Box Transcription Factor 1 (HBP1) and Sirtuin 1 (SIRT1), receptively. Estradiol 0-9 microRNA 34a Rattus norvegicus 75-82 32277160-2 2020 This study evaluated the contribution of the estrogen receptor (ER) beta in estradiol-induced modulation of social and mood-related behaviors by using mice lacking the ERbeta gene in the nervous system. Estradiol 76-85 estrogen receptor 1 (alpha) Mus musculus 45-62 32277160-2 2020 This study evaluated the contribution of the estrogen receptor (ER) beta in estradiol-induced modulation of social and mood-related behaviors by using mice lacking the ERbeta gene in the nervous system. Estradiol 76-85 estrogen receptor 1 (alpha) Mus musculus 64-72 32272706-4 2020 In contrast, direct application of estradiol in E. coli cultures decreased ClpB concentrations in bacteria, while testosterone had no effect. Estradiol 35-44 caseinolytic mitochondrial matrix peptidase chaperone subunit B Rattus norvegicus 75-79 31923417-6 2020 Estradiol- and vehicle-treated ovariectomized rats were fed either a low-fat chow diet or a 60% HFD for 4 days, after which they were perfused and brain sections were processed via immunohistochemistry for microglia-specific Iba1 protein. Estradiol 0-9 allograft inflammatory factor 1 Rattus norvegicus 225-229 31761932-9 2020 Estradiol induced beta-catenin nuclear-translocation and consequently its responsive genes in both MM and UF cells, while Estrogen receptor antagonist reversed this induction effect. Estradiol 0-9 catenin beta 1 Homo sapiens 18-30 31761932-15 2020 CONCLUSION: beta-catenin nuclear-translocation contributes to UF phenotype, beta-catenin signaling is modulated by estradiol and HDAC activity. Estradiol 115-124 catenin beta 1 Homo sapiens 76-88 32014721-6 2020 CD200 expression in human endometrial stromal cells (HESCs) stimulated with 17beta-estradiol (E2) was measured by western blotting. Estradiol 76-92 CD200 molecule Homo sapiens 0-5 31905574-6 2020 Addition of E2 to the mixture caused strong induction vtg1, cyp19b, esr1 and lhb, as well as downregulation of fshb from 0.01 mug/L onwards. Estradiol 12-14 vitellogenin 1 Danio rerio 54-58 31905574-8 2020 While each steroid class exhibited its specific activity independently in the mixture, sult2st3 and cyp2k22 were regulated by both E2 and CLO. Estradiol 131-133 cytochrome P450, family 2, subfamily K, polypeptide 22 Danio rerio 100-107 31931041-6 2020 Data also show that transmembrane G protein-coupled ER-1 (GPER) signaling is implicated in E2 control of GS profiles in each sex and alongside ERalpha, GP expression in females. Estradiol 91-93 G protein-coupled estrogen receptor 1 Rattus norvegicus 34-56 31931041-6 2020 Data also show that transmembrane G protein-coupled ER-1 (GPER) signaling is implicated in E2 control of GS profiles in each sex and alongside ERalpha, GP expression in females. Estradiol 91-93 G protein-coupled estrogen receptor 1 Rattus norvegicus 58-62 31931041-7 2020 E2 increases total 5"-AMP-activated protein kinase (AMPK) protein in female astrocytes, but stimulated pAMPK (active form) expression with equivalent potency via GPER in females and ERalpha in males. Estradiol 0-2 G protein-coupled estrogen receptor 1 Rattus norvegicus 162-166 31931041-7 2020 E2 increases total 5"-AMP-activated protein kinase (AMPK) protein in female astrocytes, but stimulated pAMPK (active form) expression with equivalent potency via GPER in females and ERalpha in males. Estradiol 0-2 estrogen receptor 1 Rattus norvegicus 182-189 31931041-8 2020 In female astrocytes, ERalpha protein was up-regulated at a lower E2 concentration and over a broader dosage range compared to males, whereas ERbeta was increased after exposure to 1-10 nM versus 100 pM E2 levels in females and males, respectively. Estradiol 66-68 estrogen receptor 1 Rattus norvegicus 22-29 31931041-8 2020 In female astrocytes, ERalpha protein was up-regulated at a lower E2 concentration and over a broader dosage range compared to males, whereas ERbeta was increased after exposure to 1-10 nM versus 100 pM E2 levels in females and males, respectively. Estradiol 203-205 estrogen receptor 2 Rattus norvegicus 142-148 32067028-1 2020 Elevated and sustained estradiol concentrations cause a gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) surge that is necessary for ovulation. Estradiol 23-32 Progonadoliberin-1 Ovis aries 56-86 32067028-1 2020 Elevated and sustained estradiol concentrations cause a gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) surge that is necessary for ovulation. Estradiol 23-32 Progonadoliberin-1 Ovis aries 88-92 32036721-0 2021 Resveratrol Combined with 17beta-Estradiol Prevents IL-1beta Induced Apoptosis in Human Nucleus Pulposus Via The PI3K/AKT/Mtor and PI3K/AKT/GSK-3beta Pathway. Estradiol 26-42 interleukin 1 alpha Homo sapiens 52-60 32036721-2 2021 Our previous study revealed that Resveratrol (RSV) combined with 17beta-estradiol (E2) was more effective in cutting down IL-1beta induced NP cell apoptosis via PI3K/AKT pathway. Estradiol 65-81 interleukin 1 alpha Homo sapiens 122-130 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 C-C motif chemokine ligand 2 Homo sapiens 197-218 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 C-C motif chemokine ligand 2 Homo sapiens 220-224 31671405-5 2020 Receptors for androgen (Ar) and estrogen (Esr1, Esr2, Gpr30) and the Cyp19a1 gene (encoding the estradiol-producing enzyme aromatase) transcripts were also detected in fetal ARC Kiss1-GFP cells with significant sex differences for Ar (higher in males) and Esr1 (higher in females). Estradiol 96-105 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 69-76 31841397-9 2020 E2 treatment resulted in 40 DEG with Krt5, Krt15, Olig3, Crabp1, and Serpinb7 upregulated in Ezh2cKO compared with control mice. Estradiol 0-2 keratin 5 Mus musculus 37-41 31841397-9 2020 E2 treatment resulted in 40 DEG with Krt5, Krt15, Olig3, Crabp1, and Serpinb7 upregulated in Ezh2cKO compared with control mice. Estradiol 0-2 serine (or cysteine) peptidase inhibitor, clade B, member 7 Mus musculus 69-77 31999691-9 2020 Under exposure to 100 ng/L 17beta-estradiol, fully feminised 61 dpf zebrafish showed transcription of ovarian gtf3ab, while masculinised (100 ng/L 17alpha-methyltestosterone treated) zebrafish only transcribed gtf3aa. Estradiol 27-43 general transcription factor IIIAa Danio rerio 210-216 31979341-6 2020 E2 increased estrogen receptor alpha (Eralpha) and the expression of the mitogen-activated protein kinase 11 (Mapk11) within 1 h of treatment and improved myoblast differentiation and myotube formation. Estradiol 0-2 estrogen receptor 1 (alpha) Mus musculus 38-45 31979341-7 2020 A significant reduction (p < 0.001) in myotube formation and in the expression of myogenic regulatory factors Mrfs (MyoD, Myog and Myh1) and the myoblast fusion related gene, Tmem8c, was observed in the presence of EPA and the combined E2/EPA treatment. Estradiol 236-238 myogenic differentiation 1 Mus musculus 116-120 30849411-9 2020 We found that E2 inhibited the expression of MT1 and MT2 in cultured oviduct cells. Estradiol 14-16 MT-1 Ovis aries 45-48 31599074-7 2020 The expression of IDO was increased in tissue explants from chorionic villi and decidua cultured in medium containing different concentrations of 17beta-estradiol or estriol, and this increase was reversed when fulvestrant was added to the medium. Estradiol 146-162 indoleamine 2,3-dioxygenase 1 Homo sapiens 18-21 31599074-8 2020 The expression of IDO was upregulated, and SOCS3 expression was downregulated the most in tissue explants from chorionic villi and decidua that were cultured in medium containing 17beta-estradiol at a concentration of 10 ng/ml or estriol at a concentration of 1 microg/ml. Estradiol 179-195 indoleamine 2,3-dioxygenase 1 Homo sapiens 18-21 33268717-3 2020 Estradiol in the CSF was strongly correlated with serum estradiol and moderately correlated with miR-126-5p in the serum exosomes. Estradiol 0-9 microRNA 126 Homo sapiens 97-104 32597145-14 2020 With the presence of FSH/LH and IGF-1 in the culture medium, progesterone and estradiol production significantly increased (p<0.001) compared to basal levels. Estradiol 78-87 insulin-like growth factor 1 Rattus norvegicus 32-37 31105126-8 2020 Administration of 17beta-estradiol (E2) for eight weeks to OVX mice restored aortic SIRT1 expression, activated eNOS, and retarded OVX-induced arterial senescence and atherosclerotic development (E2 vs. control, n=5 per group). Estradiol 18-34 sirtuin 1 Mus musculus 84-89 31105126-8 2020 Administration of 17beta-estradiol (E2) for eight weeks to OVX mice restored aortic SIRT1 expression, activated eNOS, and retarded OVX-induced arterial senescence and atherosclerotic development (E2 vs. control, n=5 per group). Estradiol 18-34 nitric oxide synthase 3, endothelial cell Mus musculus 112-116 31105126-8 2020 Administration of 17beta-estradiol (E2) for eight weeks to OVX mice restored aortic SIRT1 expression, activated eNOS, and retarded OVX-induced arterial senescence and atherosclerotic development (E2 vs. control, n=5 per group). Estradiol 36-38 sirtuin 1 Mus musculus 84-89 31105126-8 2020 Administration of 17beta-estradiol (E2) for eight weeks to OVX mice restored aortic SIRT1 expression, activated eNOS, and retarded OVX-induced arterial senescence and atherosclerotic development (E2 vs. control, n=5 per group). Estradiol 36-38 nitric oxide synthase 3, endothelial cell Mus musculus 112-116 31105126-9 2020 The effects of E2 on SIRT1 upregulation, anti-senescence and anti-atherosclerosis were attenuated by administration of a SIRT1 inhibitor, sirtinol. Estradiol 15-17 sirtuin 1 Mus musculus 21-26 31105126-9 2020 The effects of E2 on SIRT1 upregulation, anti-senescence and anti-atherosclerosis were attenuated by administration of a SIRT1 inhibitor, sirtinol. Estradiol 15-17 sirtuin 1 Mus musculus 121-126 31602590-8 2020 Western blot confirmed the increased expression of PSTAT-3 (Ser-727) and PERK1/2 proteins after estradiol + leptin treatment, confirming the estradiol + leptin cross-talk hypothesis. Estradiol 96-105 leptin Mus musculus 153-159 31602590-8 2020 Western blot confirmed the increased expression of PSTAT-3 (Ser-727) and PERK1/2 proteins after estradiol + leptin treatment, confirming the estradiol + leptin cross-talk hypothesis. Estradiol 141-150 leptin Mus musculus 108-114 31602590-9 2020 In conclusion, our in vivo studies determined specific gene expression and signaling protein changes, and further unraveled the molecular targets of estradiol + leptin that may perturb endometrial homeostasis and lead to endometrial hyperplasia development in the chronic stimulated state. Estradiol 149-158 leptin Mus musculus 161-167 31212279-0 2020 Estradiol Protects Neuropeptide Y/Agouti-related Peptide Neurons against Insulin Resistance in Females. Estradiol 0-9 neuropeptide Y Homo sapiens 19-33 31212279-3 2020 Since the anorexigenic hormone 17beta-estradiol (E2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, we hypothesized that E2 would protect against insulin resistance in NPY/AgRP neurons with diet-induced obesity (DIO). Estradiol 31-47 neuropeptide Y Homo sapiens 134-148 31212279-3 2020 Since the anorexigenic hormone 17beta-estradiol (E2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, we hypothesized that E2 would protect against insulin resistance in NPY/AgRP neurons with diet-induced obesity (DIO). Estradiol 31-47 neuropeptide Y Homo sapiens 173-176 31212279-3 2020 Since the anorexigenic hormone 17beta-estradiol (E2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, we hypothesized that E2 would protect against insulin resistance in NPY/AgRP neurons with diet-induced obesity (DIO). Estradiol 31-47 neuropeptide Y Homo sapiens 260-263 31666443-5 2019 The concentration of oviductal E2 was positively correlated with the mRNA expressions of nuclear P4 receptor (PGR) and protein disulfide isomerase family A member 4 (PDIA4), which is related to protein secretion, in the ampulla and with estrogen receptor alpha (ESR1) mRNA expression in the isthmus. Estradiol 31-33 protein disulfide isomerase family A member 4 Bos taurus 119-164 31666443-5 2019 The concentration of oviductal E2 was positively correlated with the mRNA expressions of nuclear P4 receptor (PGR) and protein disulfide isomerase family A member 4 (PDIA4), which is related to protein secretion, in the ampulla and with estrogen receptor alpha (ESR1) mRNA expression in the isthmus. Estradiol 31-33 protein disulfide isomerase family A member 4 Bos taurus 166-171 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 190-199 nuclear receptor coactivator 6 Homo sapiens 133-164 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 190-199 nuclear receptor coactivator 6 Homo sapiens 166-171 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 201-203 nuclear receptor coactivator 6 Homo sapiens 133-164 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 201-203 nuclear receptor coactivator 6 Homo sapiens 166-171 31744881-7 2019 NCOA6 knockout reduced ERalpha recruitment and abolished all of the aforementioned E2-induced events, making GREB1 completely insensitive to E2 induction. Estradiol 83-85 nuclear receptor coactivator 6 Homo sapiens 0-5 31920957-2 2019 We aimed to identify the source of estradiol by analyzing androgen secretion profiles and measuring anti-Mullerian hormone (AMH) and inhibin B concentrations during childhood and puberty in this group of patients. Estradiol 35-44 anti-Mullerian hormone Homo sapiens 124-127 31791345-15 2019 Using antibodies against SYCP3 to identify pachytene stage oocytes we found that progesterone and estradiol together delayed progression of oocytes through prophase I. Estradiol 98-107 synaptonemal complex protein 3 Mus musculus 25-30 31513792-2 2019 To exert its effects, estradiol binds mainly to estrogen receptors ESR1 and ESR2 (alpha and beta, respectively), expressed in brain regions including the hippocampus, limbic regions and hypothalamic nuclei. Estradiol 22-31 estrogen receptor 1 Rattus norvegicus 67-71 31513792-2 2019 To exert its effects, estradiol binds mainly to estrogen receptors ESR1 and ESR2 (alpha and beta, respectively), expressed in brain regions including the hippocampus, limbic regions and hypothalamic nuclei. Estradiol 22-31 estrogen receptor 2 Rattus norvegicus 76-80 31735954-27 2019 The AMH decline may either be a direct effect of androgens or an indirect one via conversion to oestradiol and acting through the upregulation of ERalpha, which is known to stimulate the AMH promoter. Estradiol 96-106 anti-Mullerian hormone Homo sapiens 4-7 31398266-9 2019 The observation that Krox20 expression is inhibited by DHT and E2 negates the hypothesis that the effect of sex hormones is mediated by an increase in Krox20 expression. Estradiol 63-65 early growth response 2 Mus musculus 21-27 31560827-0 2019 E2 -mediated EMT by activation of beta-catenin/Snail signalling during the development of ovarian endometriosis. Estradiol 0-2 catenin beta 1 Homo sapiens 34-46 31560827-6 2019 These results suggested that beta-catenin signalling functions as the Snail activator and plays a critical role in oestradiol-induced EMT in endometriosis. Estradiol 115-125 catenin beta 1 Homo sapiens 29-41 31393569-1 2019 CONTEXT: The luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is mainly expressed in gonads and plays important roles in estradiol production, ovulation and luteal formation. Estradiol 132-141 luteinizing hormone/choriogonadotropin receptor Homo sapiens 13-64 31393569-1 2019 CONTEXT: The luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is mainly expressed in gonads and plays important roles in estradiol production, ovulation and luteal formation. Estradiol 132-141 luteinizing hormone/choriogonadotropin receptor Homo sapiens 66-71 31421163-8 2019 MiR-29a overexpression in KGN and COV434 cells inhibited cell proliferation, arrested cell-cycle progression, and decreased aromatase expression and estradiol production. Estradiol 149-158 microRNA 29a Homo sapiens 0-7 31849684-10 2019 These results suggest that activation of alpha7nAChR with anisodamine could decrease serum potassium and on-site mortality in CS through estradiol-induced enhancement of insulin sensitivity. Estradiol 137-146 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 41-52 31819689-0 2019 Activation of ATM-c-IAP1 Pathway Mediates the Protective Effects of Estradiol in Human Vascular Endothelial Cells Exposed to Intermittent Hypoxia. Estradiol 68-77 ATM serine/threonine kinase Homo sapiens 14-17 31628182-1 2019 Activation of the membrane estrogen receptor G-protein-coupled estrogen receptor (GPER) in ovariectomized mice via the GPER agonist G-1 mimics the beneficial effects of 17beta-estradiol (E2) on hippocampal CA1 spine density and memory consolidation, yet the cell-signaling mechanisms mediating these effects remain unclear. Estradiol 169-185 carbonic anhydrase 1 Mus musculus 206-209 31350850-10 2019 Furthermore, knockdown of YAP1 in granulosa cells inhibited FSH-induced estradiol biosynthesis. Estradiol 72-81 Yes1 associated transcriptional regulator Bos taurus 26-30 30381823-10 2019 In females, oestradiol rapidly enhances the effect of cocaine on dopamine release, likely via activation of ERbeta. Estradiol 12-22 estrogen receptor 2 Rattus norvegicus 108-114 31162329-15 2019 Female platelets have both increased aggregation and activation potential, and estradiol pre-treatment feminizes male platelets to approximate female platelet activation with PAF. Estradiol 79-88 PCNA clamp associated factor Homo sapiens 175-178 31479724-3 2019 Therefore, the aim of the present study was to get closer insight in the E2-induced decrease in NTPDase and eN activity in the hippocampal synaptic compartment of male rats and to identify estradiol receptors (ERs i.e. ERalpha, ERbeta or GPER1) responsible for the observed effects of E2. Estradiol 73-75 estrogen receptor 1 Rattus norvegicus 219-226 31479724-3 2019 Therefore, the aim of the present study was to get closer insight in the E2-induced decrease in NTPDase and eN activity in the hippocampal synaptic compartment of male rats and to identify estradiol receptors (ERs i.e. ERalpha, ERbeta or GPER1) responsible for the observed effects of E2. Estradiol 73-75 estrogen receptor 2 Rattus norvegicus 228-234 31479724-3 2019 Therefore, the aim of the present study was to get closer insight in the E2-induced decrease in NTPDase and eN activity in the hippocampal synaptic compartment of male rats and to identify estradiol receptors (ERs i.e. ERalpha, ERbeta or GPER1) responsible for the observed effects of E2. Estradiol 73-75 G protein-coupled estrogen receptor 1 Rattus norvegicus 238-243 31479724-3 2019 Therefore, the aim of the present study was to get closer insight in the E2-induced decrease in NTPDase and eN activity in the hippocampal synaptic compartment of male rats and to identify estradiol receptors (ERs i.e. ERalpha, ERbeta or GPER1) responsible for the observed effects of E2. Estradiol 285-287 estrogen receptor 1 Rattus norvegicus 219-226 31724834-6 2019 Promoter activation of OAT1 was assessed by luciferase assays carried out by Opossum kidney (OK) cells, transiently transfected with promoter constructs of human OAT1 and expression vectors for ERalpha and exposed to 100 nmol/L 17beta-estradiol. Estradiol 228-244 solute carrier family 22 member 6 Homo sapiens 23-27 31322169-8 2019 The plasma levels of other steroids, including testosterone, estradiol, and cortisol, were not affected in the lhb mutants, while the levels of gonad hormones testosterone and estradiol were significantly increased in the star mutants. Estradiol 176-185 steroidogenic acute regulatory protein Danio rerio 222-226 31585527-4 2019 Herein, to the best of our knowledge for the first time, spatial memory and synaptic plasticity at the CA1 synapse of a uremic ovariectomized rat model of menopause was characterized by estradiol replacement alone. Estradiol 186-195 carbonic anhydrase 1 Rattus norvegicus 103-106 31553790-2 2019 SUMMARY ANSWER: AREG mediates the hCG-induced up-regulation of aromatase expression and estradiol (E2) production in hGL cells. Estradiol 88-97 cathepsin G Homo sapiens 34-37 31553790-2 2019 SUMMARY ANSWER: AREG mediates the hCG-induced up-regulation of aromatase expression and estradiol (E2) production in hGL cells. Estradiol 99-101 cathepsin G Homo sapiens 34-37 31553790-18 2019 In addition, inhibition of EGFR activity and AREG knockdown attenuated hCG-induced up-regulation of aromatase expression and E2 production. Estradiol 125-127 cathepsin G Homo sapiens 71-74 31553790-23 2019 WIDER IMPLICATIONS OF THE FINDINGS: Our results provide the first evidence that hCG-induced AREG contributes to aromatase expression and E2 production in the luteal phase of the menstrual cycle. Estradiol 137-139 cathepsin G Homo sapiens 80-83 31265816-4 2019 Current research utilized combinatory immunocytochemistry, laser-microdissection, and Western blot techniques in a pharmacological approach to address the hypothesis that ERalpha and/or -beta mediate sex-dimorphic VMN GABAergic and/or nitrergic nerve cell receptivity to NE and estradiol during IIH. Estradiol 278-287 estrogen receptor 1 Rattus norvegicus 171-178 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 0-16 POU class 5 homeobox 1 Homo sapiens 146-150 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 0-16 aldehyde dehydrogenase 1 family member A1 Homo sapiens 163-170 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 18-20 POU class 5 homeobox 1 Homo sapiens 146-150 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 18-20 aldehyde dehydrogenase 1 family member A1 Homo sapiens 163-170 30862292-0 2019 PGRMC1 can trigger estrogen-dependent proliferation of breast cancer cells: estradiol vs. equilin vs. ethinylestradiol. Estradiol 76-85 progesterone receptor membrane component 1 Homo sapiens 0-6 30862292-4 2019 Methods: Non-transfected and PGRMC1-transfected T-47D cells were stimulated with estradiol (E2), with equilin (EQ), or with ethinylestradiol (EE) at 1, 10, and 100 nmol/l. Estradiol 81-90 progesterone receptor membrane component 1 Homo sapiens 29-35 30862292-4 2019 Methods: Non-transfected and PGRMC1-transfected T-47D cells were stimulated with estradiol (E2), with equilin (EQ), or with ethinylestradiol (EE) at 1, 10, and 100 nmol/l. Estradiol 92-94 progesterone receptor membrane component 1 Homo sapiens 29-35 30985874-6 2019 RESULTS: Boys with obesity had lower total testosterone (P < 0.0001) and higher concentrations of the urinary estradiol metabolite, E1c, (P = 0.046) than boys with NW. Estradiol 110-119 small nucleolar RNA, H/ACA box 73B Homo sapiens 132-135 31207361-6 2019 Our results demonstrate that 17beta-HSD7, STS and 11beta-HSD2 are all regulated by the same estrogen estradiol via ERalpha. Estradiol 101-110 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 50-61 31511352-3 2019 Here, we demonstrated that E2 widely activated adipose inflammatory factors such as fatty acid desaturase 1 (FADS1), IL6, and TNFalpha in LTED breast cancer cells. Estradiol 27-29 fatty acid desaturase 1 Homo sapiens 84-107 31511352-3 2019 Here, we demonstrated that E2 widely activated adipose inflammatory factors such as fatty acid desaturase 1 (FADS1), IL6, and TNFalpha in LTED breast cancer cells. Estradiol 27-29 fatty acid desaturase 1 Homo sapiens 109-114 31511352-5 2019 Furthermore, dexamethasone was synergistic or additive with E2 in upregulating FADS1 and IL6 expression, whereas it selectively and constantly suppressed TNFalpha expression induced by E2 in LTED breast cancer cells. Estradiol 60-62 fatty acid desaturase 1 Homo sapiens 79-84 33319967-5 2019 In Hd-rR, E2 exposure induced XY sex-reversal at > 10 ng mL-1, and in all fish feminization occurred 500 ng mL-1. Estradiol 10-12 L1 cell adhesion molecule Mus musculus 57-61 33319967-6 2019 In HNI-II, E2 induced XY sex-reversal at 50 and 250 ng mL-1, but only at rates below 20%. Estradiol 11-13 L1 cell adhesion molecule Mus musculus 55-59 31507154-0 2019 17beta-estradiol replacement therapy induces eNOS, nNOS and estrogen receptor beta in hypophysectomized rats with inflamed footpads. Estradiol 0-16 estrogen receptor 2 Rattus norvegicus 60-82 31507154-10 2019 The higher levels of estradiol-induced eNOS and nNOS ocurred perhaps through the activation of ER beta. Estradiol 21-30 estrogen receptor 2 Rattus norvegicus 95-102 31576731-10 2019 The higher levels of estradiol-induced eNOS and nNOS ocurred perhaps through the activation of ER beta. Estradiol 21-30 estrogen receptor 2 Rattus norvegicus 95-102 31152825-0 2019 Estradiol-induced RORalpha expression positively regulates osteoblast differentiation. Estradiol 0-9 RAR-related orphan receptor alpha Mus musculus 18-26 31152825-2 2019 Several studies show that estradiol is related to RORalpha expression. Estradiol 26-35 RAR-related orphan receptor alpha Mus musculus 50-58 31152825-4 2019 Here, we showed that estradiol induces RORalpha expression in C3H10T1/2 and MC3T3-E1 cells. Estradiol 21-30 RAR-related orphan receptor alpha Mus musculus 39-47 31152825-7 2019 Furthermore, RORalpha knockdown suppressed estradiol-induced BMP2 and Runx2 protein level. Estradiol 43-52 RAR-related orphan receptor alpha Mus musculus 13-21 31152825-7 2019 Furthermore, RORalpha knockdown suppressed estradiol-induced BMP2 and Runx2 protein level. Estradiol 43-52 runt related transcription factor 2 Mus musculus 70-75 31152825-8 2019 Also, we confirmed that estradiol-induced ALP staining and matrix mineralization was attenuated in RORalpha knockdown. Estradiol 24-33 RAR-related orphan receptor alpha Mus musculus 99-107 31152825-9 2019 Summarily, these results suggest that estradiol-induced RORalpha promotes osteoblast differentiation. Estradiol 38-47 RAR-related orphan receptor alpha Mus musculus 56-64 30875186-14 2019 A correlation was found between clinical pregnancy rate and AMH and E2 levels on beta hCG testing day. Estradiol 68-70 anti-Mullerian hormone Homo sapiens 60-63 31271831-8 2019 pERK significantly increased in excitatory cells after treatment with a low dose of estradiol and increased in inhibitory cells after treatment with a high dose of estradiol. Estradiol 84-93 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 0-4 31271831-8 2019 pERK significantly increased in excitatory cells after treatment with a low dose of estradiol and increased in inhibitory cells after treatment with a high dose of estradiol. Estradiol 164-173 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 0-4 31430865-0 2019 17beta-Estradiol Modulates SIRT1 and Halts Oxidative Stress-Mediated Cognitive Impairment in a Male Aging Mouse Model. Estradiol 0-16 sirtuin 1 Mus musculus 27-32 31430865-5 2019 In this study, we evaluated the estrogen receptor alpha (ERalpha)/silent mating type information regulation 2 homolog 1 (SIRT1)-dependent antioxidant efficacy of 17beta-estradiol against d-gal-induced oxidative damage-mediated cognitive dysfunction in a male mouse model. Estradiol 162-178 estrogen receptor 1 (alpha) Mus musculus 32-55 31430865-5 2019 In this study, we evaluated the estrogen receptor alpha (ERalpha)/silent mating type information regulation 2 homolog 1 (SIRT1)-dependent antioxidant efficacy of 17beta-estradiol against d-gal-induced oxidative damage-mediated cognitive dysfunction in a male mouse model. Estradiol 162-178 estrogen receptor 1 (alpha) Mus musculus 57-64 31430865-5 2019 In this study, we evaluated the estrogen receptor alpha (ERalpha)/silent mating type information regulation 2 homolog 1 (SIRT1)-dependent antioxidant efficacy of 17beta-estradiol against d-gal-induced oxidative damage-mediated cognitive dysfunction in a male mouse model. Estradiol 162-178 sirtuin 1 Mus musculus 121-126 31430865-6 2019 The results indicate that 17beta-estradiol, by stimulating ERalpha/SIRT1, halts d-gal-induced oxidative stress-mediated JNK/NF-kB overexpression, neuroinflammation and neuronal apoptosis. Estradiol 26-42 estrogen receptor 1 (alpha) Mus musculus 59-66 31430865-6 2019 The results indicate that 17beta-estradiol, by stimulating ERalpha/SIRT1, halts d-gal-induced oxidative stress-mediated JNK/NF-kB overexpression, neuroinflammation and neuronal apoptosis. Estradiol 26-42 sirtuin 1 Mus musculus 67-72 31430865-8 2019 Interestingly, inhibition of SIRT1 with Ex527 (a potent and selective SIRT1 inhibitor) further enhanced d-gal-induced toxicity and abolished the beneficial effect of 17beta-estradiol. Estradiol 166-182 sirtuin 1 Mus musculus 29-34 31430865-8 2019 Interestingly, inhibition of SIRT1 with Ex527 (a potent and selective SIRT1 inhibitor) further enhanced d-gal-induced toxicity and abolished the beneficial effect of 17beta-estradiol. Estradiol 166-182 sirtuin 1 Mus musculus 70-75 31430865-9 2019 Most importantly, for the first time, our molecular docking study reveals that 17beta-estradiol allosterically increases the expression of SIRT1 and abolishes the inhibitory potential of d-ga. Estradiol 79-95 sirtuin 1 Mus musculus 139-144 31430865-10 2019 In summary, we can conclude that 17beta-estradiol, in an ERalpha/SIRT1-dependent manner, abrogates d-gal-induced oxidative stress-mediated memory impairment, neuroinflammation, and neurodegeneration in adult mice. Estradiol 33-49 estrogen receptor 1 (alpha) Mus musculus 57-64 31430865-10 2019 In summary, we can conclude that 17beta-estradiol, in an ERalpha/SIRT1-dependent manner, abrogates d-gal-induced oxidative stress-mediated memory impairment, neuroinflammation, and neurodegeneration in adult mice. Estradiol 33-49 sirtuin 1 Mus musculus 65-70 31343176-3 2019 Blockade of 17beta-HSD2 is thought to increase intracellular estradiol and testosterone in bone, thereby inhibiting bone resorption by osteoclasts and stimulating bone formation by osteoblasts, respectively. Estradiol 61-70 hydroxysteroid (17-beta) dehydrogenase 2 Rattus norvegicus 12-23 31447779-0 2019 17beta-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet beta Cells Through GPER and Akt/mTOR/GLUT2 Pathway. Estradiol 0-16 G protein-coupled estrogen receptor 1 Rattus norvegicus 100-104 31447779-0 2019 17beta-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet beta Cells Through GPER and Akt/mTOR/GLUT2 Pathway. Estradiol 0-16 solute carrier family 2 member 2 Rattus norvegicus 118-123 31447779-1 2019 Aims: To explore the molecular mechanism by which 17beta-estradiol (estrogen 2, E2) regulates glucose transporter 2 (GLUT2) and insulin secretion in islet beta cells through G protein-coupled estrogen receptor (GPER) via Akt/mTOR pathway. Estradiol 50-66 solute carrier family 2 member 2 Rattus norvegicus 94-115 31447779-1 2019 Aims: To explore the molecular mechanism by which 17beta-estradiol (estrogen 2, E2) regulates glucose transporter 2 (GLUT2) and insulin secretion in islet beta cells through G protein-coupled estrogen receptor (GPER) via Akt/mTOR pathway. Estradiol 50-66 solute carrier family 2 member 2 Rattus norvegicus 117-122 31447779-1 2019 Aims: To explore the molecular mechanism by which 17beta-estradiol (estrogen 2, E2) regulates glucose transporter 2 (GLUT2) and insulin secretion in islet beta cells through G protein-coupled estrogen receptor (GPER) via Akt/mTOR pathway. Estradiol 50-66 G protein-coupled estrogen receptor 1 Rattus norvegicus 174-209 31447779-1 2019 Aims: To explore the molecular mechanism by which 17beta-estradiol (estrogen 2, E2) regulates glucose transporter 2 (GLUT2) and insulin secretion in islet beta cells through G protein-coupled estrogen receptor (GPER) via Akt/mTOR pathway. Estradiol 50-66 G protein-coupled estrogen receptor 1 Rattus norvegicus 211-215 31012223-4 2019 We found that in cultured primary neurons, 17beta-estradiol (E2) reduced Cav1.2 protein through estrogen receptor alpha (ERalpha). Estradiol 43-59 estrogen receptor 1 (alpha) Mus musculus 96-119 31012223-4 2019 We found that in cultured primary neurons, 17beta-estradiol (E2) reduced Cav1.2 protein through estrogen receptor alpha (ERalpha). Estradiol 43-59 estrogen receptor 1 (alpha) Mus musculus 121-128 31012223-4 2019 We found that in cultured primary neurons, 17beta-estradiol (E2) reduced Cav1.2 protein through estrogen receptor alpha (ERalpha). Estradiol 61-63 estrogen receptor 1 (alpha) Mus musculus 96-119 31012223-4 2019 We found that in cultured primary neurons, 17beta-estradiol (E2) reduced Cav1.2 protein through estrogen receptor alpha (ERalpha). Estradiol 61-63 estrogen receptor 1 (alpha) Mus musculus 121-128 31141131-1 2019 Both membrane and nuclear fractions of estrogen receptor 1 (ESR1) mediate 17beta-estradiol (E2) actions. Estradiol 74-90 estrogen receptor 1 (alpha) Mus musculus 39-58 31141131-1 2019 Both membrane and nuclear fractions of estrogen receptor 1 (ESR1) mediate 17beta-estradiol (E2) actions. Estradiol 74-90 estrogen receptor 1 (alpha) Mus musculus 60-64 31141131-1 2019 Both membrane and nuclear fractions of estrogen receptor 1 (ESR1) mediate 17beta-estradiol (E2) actions. Estradiol 92-94 estrogen receptor 1 (alpha) Mus musculus 39-58 31141131-1 2019 Both membrane and nuclear fractions of estrogen receptor 1 (ESR1) mediate 17beta-estradiol (E2) actions. Estradiol 92-94 estrogen receptor 1 (alpha) Mus musculus 60-64 31141131-2 2019 Mice expressing nuclear (n)ESR1 but lacking membrane (m)ESR1 (nuclear-only estrogen receptor 1 [NOER] mice) show reduced E2 responsivity and reproductive abnormalities culminating in adult male and female infertility. Estradiol 121-123 estrogen receptor 1 (alpha) Mus musculus 27-31 31167231-2 2019 Meanwhile, kisspeptin in the anteroventral periventricular nucleus (AVPV) region has been implicated in estradiol (E2)-induced GnRH surges. Estradiol 104-113 gonadotropin releasing hormone 1 Mus musculus 127-131 31269532-7 2019 In WTs, pulsatile Kiss-10 together with constant oestradiol significantly increased GnRH pulsatility, whereas, in GABAB1KOs, oestradiol alone increased GnRH pulsatility and this was reversed by pulsatile Kiss-10 addition. Estradiol 49-59 gonadotropin releasing hormone 1 Mus musculus 84-88 31269532-7 2019 In WTs, pulsatile Kiss-10 together with constant oestradiol significantly increased GnRH pulsatility, whereas, in GABAB1KOs, oestradiol alone increased GnRH pulsatility and this was reversed by pulsatile Kiss-10 addition. Estradiol 125-135 gonadotropin releasing hormone 1 Mus musculus 152-156 31116958-0 2019 Role of adiponectin/peroxisome proliferator-activated receptor alpha signaling in human chorionic gonadotropin-induced estradiol synthesis in human luteinized granulosa cells. Estradiol 119-128 peroxisome proliferator activated receptor alpha Homo sapiens 20-68 31413616-0 2019 Estradiol accelerates liver regeneration through estrogen receptor alpha. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 49-72 31413616-2 2019 In this study, we demonstrated estradiol-induced estrogen receptor alpha (ERalpha) expression. Estradiol 31-40 estrogen receptor 1 (alpha) Mus musculus 49-72 31413616-2 2019 In this study, we demonstrated estradiol-induced estrogen receptor alpha (ERalpha) expression. Estradiol 31-40 estrogen receptor 1 (alpha) Mus musculus 74-81 31413616-5 2019 Conclusion: Moreover, estradiol administration accelerated liver regeneration through ERalpha, indicating the feasibility of the estrogen-ERalpha axis as a target for accelerating the rate of liver regeneration. Estradiol 22-31 estrogen receptor 1 (alpha) Mus musculus 86-93 31413616-5 2019 Conclusion: Moreover, estradiol administration accelerated liver regeneration through ERalpha, indicating the feasibility of the estrogen-ERalpha axis as a target for accelerating the rate of liver regeneration. Estradiol 22-31 estrogen receptor 1 (alpha) Mus musculus 138-145 30866655-4 2019 Global estrogen receptor alpha (ERalpha) knockout (KO) mice exhibit a disruption of the HPG axis, resulting in hormonal dysregulation in which female ERalpha KO mice have elevated levels of serum estradiol (E2), testosterone, and LH. Estradiol 207-209 estrogen receptor 1 (alpha) Mus musculus 32-39 30866655-4 2019 Global estrogen receptor alpha (ERalpha) knockout (KO) mice exhibit a disruption of the HPG axis, resulting in hormonal dysregulation in which female ERalpha KO mice have elevated levels of serum estradiol (E2), testosterone, and LH. Estradiol 207-209 estrogen receptor 1 (alpha) Mus musculus 150-157 31059046-0 2019 Inhibitory effect of 17beta-estradiol on triglyceride synthesis in skeletal muscle cells is dependent on ESR1 and not ESR2. Estradiol 21-37 estrogen receptor 1 (alpha) Mus musculus 105-109 31141240-5 2019 We observed that 17beta-estradiol abolished the stimulatory effect of corticotropin-releasing hormone on intracellular reactive oxygen species levels and counteracted its inhibitory effect on endothelial nitric oxide synthase activity and nitric oxide release. Estradiol 17-33 corticotropin releasing hormone Homo sapiens 70-101 31141240-7 2019 Finally, 17beta-estradiol significantly increased glutathione levels and the glutathione/glutathione + glutathione disulfide ratio, an action that was partially blocked by corticotropin-releasing hormone. Estradiol 9-25 corticotropin releasing hormone Homo sapiens 172-203 31141240-8 2019 Our results reveal that 17beta-estradiol counterbalances corticotropin-releasing hormone-mediated pro-inflammatory action and thereby maintains the physiological threshold of the endothelial cell redox environment. Estradiol 24-40 corticotropin releasing hormone Homo sapiens 57-88 30742936-7 2019 These results suggest that both the rise in circulating levels of E2 and the decline in hippocampal THP levels at the onset of puberty trigger maximal levels of alpha4betadelta expression in the CA1 hippocampus. Estradiol 66-68 carbonic anhydrase 1 Mus musculus 195-198 30946012-2 2019 Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release and positive feedback generating preovulatory GnRH/LH surges. Estradiol 0-9 gonadotropin releasing hormone 1 Mus musculus 49-53 30946012-2 2019 Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release and positive feedback generating preovulatory GnRH/LH surges. Estradiol 0-9 gonadotropin releasing hormone 1 Mus musculus 133-137 30677730-0 2019 Determination and reduced life expectancy model and molecular docking analyses of estrogenic potentials of 17beta-estradiol, bisphenol A and nonylphenol on expression of vitellogenin gene (vtg1) in zebrafish. Estradiol 107-123 vitellogenin 1 Danio rerio 189-193 30703434-5 2019 By binding to estrogen receptor alpha (ERalpha), estradiol changes the activity of VMH neurons that project to the PAG. Estradiol 49-58 estrogen receptor 1 Rattus norvegicus 39-46 30738018-9 2019 We conclude that the action of both hormones, estradiol and progesterone, is necessary to reduce proliferation and increase apoptosis in colon tumors, probably through estrogen receptor beta activation. Estradiol 46-55 estrogen receptor 2 Rattus norvegicus 168-190 30325236-0 2019 Expression of programmed death-1 (PD-1) and its ligand PD-L1 is upregulated in endometriosis and promoted by 17beta-estradiol. Estradiol 109-125 CD274 molecule Homo sapiens 55-60 30325236-12 2019 In addition, treatment with 17beta-estradiol upregulated PD-L1 expression in eutopic epithelial cells in EM. Estradiol 28-44 CD274 molecule Homo sapiens 57-62 30152543-7 2019 Estradiol, through estrogen receptor beta, released CTBP1 from CYP19A1 promoter triggering its transcription and modulating PCa cell proliferation. Estradiol 0-9 C-terminal binding protein 1 Mus musculus 52-57 30152543-7 2019 Estradiol, through estrogen receptor beta, released CTBP1 from CYP19A1 promoter triggering its transcription and modulating PCa cell proliferation. Estradiol 0-9 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 63-70 30152543-9 2019 In the NSG model, CTBP1 depleted PCa xenografts showed an increase in CYP19A1 expression with subsequent increment in intratumor estradiol concentrations. Estradiol 129-138 C-terminal binding protein 1 Mus musculus 18-23 30645111-4 2019 Blockade of 17beta-HSD2 in bone is thought to increase intracellular estradiol (E2) and testosterone (T), which thereby inhibits bone resorption by osteoclasts and stimulates bone formation by osteoblasts, respectively. Estradiol 69-78 hydroxysteroid (17-beta) dehydrogenase 2 Mus musculus 12-23 30645111-4 2019 Blockade of 17beta-HSD2 in bone is thought to increase intracellular estradiol (E2) and testosterone (T), which thereby inhibits bone resorption by osteoclasts and stimulates bone formation by osteoblasts, respectively. Estradiol 80-82 hydroxysteroid (17-beta) dehydrogenase 2 Mus musculus 12-23 30728084-3 2019 The steroid hormone 17beta-estradiol, along with its receptors ERalpha and ERbeta, is thought to be crucial for sex differences and is expected to be protective, but this may not hold true for males. Estradiol 20-36 estrogen receptor 1 (alpha) Mus musculus 63-70 31119046-5 2019 Estradiol significantly induced phosphorylation of InsR-beta and IRS-1, whereas insulin significantly induced phosphorylation of ER-alpha. Estradiol 0-9 insulin receptor substrate 1 Mus musculus 65-70 30400046-6 2019 Moreover, we found that local Gper expression is regulated negatively by 17beta-estradiol (E2) and progesterone (P4) and fluctuates during the estrus cycle, being minimal in proestrus. Estradiol 73-89 G protein-coupled estrogen receptor 1 Rattus norvegicus 30-34 30400046-6 2019 Moreover, we found that local Gper expression is regulated negatively by 17beta-estradiol (E2) and progesterone (P4) and fluctuates during the estrus cycle, being minimal in proestrus. Estradiol 91-93 G protein-coupled estrogen receptor 1 Rattus norvegicus 30-34 30400046-8 2019 We found a rapid estradiol stimulatory effect on PRL secretion mediated by GPER, both in vitro and ex vivo, using a GPER agonist G1, and this effect was prevented by the GPER antagonist G36, demonstrating a novel role for this receptor. Estradiol 17-26 G protein-coupled estrogen receptor 1 Rattus norvegicus 75-79 30400046-8 2019 We found a rapid estradiol stimulatory effect on PRL secretion mediated by GPER, both in vitro and ex vivo, using a GPER agonist G1, and this effect was prevented by the GPER antagonist G36, demonstrating a novel role for this receptor. Estradiol 17-26 G protein-coupled estrogen receptor 1 Rattus norvegicus 116-120 30400046-8 2019 We found a rapid estradiol stimulatory effect on PRL secretion mediated by GPER, both in vitro and ex vivo, using a GPER agonist G1, and this effect was prevented by the GPER antagonist G36, demonstrating a novel role for this receptor. Estradiol 17-26 G protein-coupled estrogen receptor 1 Rattus norvegicus 116-120 30130290-3 2019 We hypothesized that bazedoxifene may induce greater vasoprotective effects than estradiol due to enhanced activation of the G-protein-coupled estrogen receptor. Estradiol 81-90 estrogen receptor 1 (alpha) Mus musculus 143-160 29133279-0 2019 Effect of 17beta-estradiol on estrogen receptor negative breast cancer cells in an osteolytic mouse model. Estradiol 10-26 estrogen receptor 1 (alpha) Mus musculus 30-47 30590923-6 2019 Specifically, modulation of the distance between the target lysine and the phosphodegron sequence of the substrate, the distance between the substrate lysine and the active site cysteine of the Ub conjugation enzyme (E2) bound to the cullin-RING scaffold, and flexibility of the bound E2 can lead to significant differences in the processing of K48-linked chains on substrates, potentially leading to differences in biological outcomes. Estradiol 217-219 CDK2 associated cullin domain 1 Homo sapiens 234-240 30590923-6 2019 Specifically, modulation of the distance between the target lysine and the phosphodegron sequence of the substrate, the distance between the substrate lysine and the active site cysteine of the Ub conjugation enzyme (E2) bound to the cullin-RING scaffold, and flexibility of the bound E2 can lead to significant differences in the processing of K48-linked chains on substrates, potentially leading to differences in biological outcomes. Estradiol 285-287 CDK2 associated cullin domain 1 Homo sapiens 234-240 30507149-6 2019 To explore the mode of action of E2, target proteins were investigated using phage display biopanning, and acid ceramidase 1 (ASAH1) was identified as an E2-binding protein. Estradiol 33-35 N-acylsphingosine amidohydrolase 1 Homo sapiens 126-131 30507149-7 2019 Drug affinity responsive target stability (DARTS) and ASAH1 activity assays revealed the direct binding of E2 to ASAH1. Estradiol 107-109 N-acylsphingosine amidohydrolase 1 Homo sapiens 54-59 30507149-7 2019 Drug affinity responsive target stability (DARTS) and ASAH1 activity assays revealed the direct binding of E2 to ASAH1. Estradiol 107-109 N-acylsphingosine amidohydrolase 1 Homo sapiens 113-118 31536986-2 2019 Estradiol modulates cognitive functions based on the expression pattern of its receptor subtypes including estrogen receptor (ER) alpha, beta, and G protein-coupled receptor 30 (GPR30). Estradiol 0-9 estrogen receptor 1 Rattus norvegicus 107-135 31536986-2 2019 Estradiol modulates cognitive functions based on the expression pattern of its receptor subtypes including estrogen receptor (ER) alpha, beta, and G protein-coupled receptor 30 (GPR30). Estradiol 0-9 G protein-coupled estrogen receptor 1 Rattus norvegicus 147-176 31536986-2 2019 Estradiol modulates cognitive functions based on the expression pattern of its receptor subtypes including estrogen receptor (ER) alpha, beta, and G protein-coupled receptor 30 (GPR30). Estradiol 0-9 G protein-coupled estrogen receptor 1 Rattus norvegicus 178-183 31364945-8 2019 Virus-specific IgG-secreting and IL-4-secreting cells were also reduced in estradiol-implanted mice. Estradiol 75-84 interleukin 4 Mus musculus 33-37 30259506-3 2019 This research aims to evaluate the concentration of most types of MMPs: collagenases (MMP-1, -3, -8, -13), matrilysin (MMP-7), gelatinase (MMP-9), and metalloelastase (MMP-12) in serum of women in reproductive age in relation with their body mass index (BMI), age, oestradiol, and progesterone concentrations. Estradiol 265-275 matrix metallopeptidase 1 Homo sapiens 66-70 30412732-0 2019 17beta-Estradiol protects mesenchymal stem cells against high glucose-induced mitochondrial oxidants production via Nrf2/Sirt3/MnSOD signaling. Estradiol 0-16 sirtuin 3 Mus musculus 121-126 30020241-5 2019 Measurement of the longitudinally gestational change of plasmin-alpha2-antiplasmin (PAP) complex, testosterone, estradiol in preeclampsia patients and normal pregnant women demonstrated that the circulating PAP and testosterone levels in the early-onset preeclampsia (E-PE) patients were substantially higher, whereas estradiol concentration was significantly lower than that in normal pregnant controls from early pregnancy throughout gestation. Estradiol 112-121 regenerating family member 3 alpha Homo sapiens 207-210 30020241-5 2019 Measurement of the longitudinally gestational change of plasmin-alpha2-antiplasmin (PAP) complex, testosterone, estradiol in preeclampsia patients and normal pregnant women demonstrated that the circulating PAP and testosterone levels in the early-onset preeclampsia (E-PE) patients were substantially higher, whereas estradiol concentration was significantly lower than that in normal pregnant controls from early pregnancy throughout gestation. Estradiol 318-327 regenerating family member 3 alpha Homo sapiens 207-210 30558263-8 2018 Additionally, exogenous 17beta-estradiol stimulated NOX/DUOX expression as well as H2O2 production, and this effect was mainly mediated through ERalpha. Estradiol 24-40 estrogen receptor 1 Rattus norvegicus 144-151 30371725-0 2018 17beta-estradiol promotes recovery after myocardial infarction by enhancing homing and angiogenic capacity of bone marrow-derived endothelial progenitor cells through ERalpha-SDF-1/CXCR4 crosstalking. Estradiol 0-16 estrogen receptor 1 (alpha) Mus musculus 167-174 30411385-0 2018 Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes. Estradiol 8-17 uncoupling protein 1 Homo sapiens 38-42 30411385-6 2018 Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to Iso on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes. Estradiol 15-31 uncoupling protein 1 Homo sapiens 115-119 30411385-7 2018 Estradiol decreased Iso-induced Ucp1 expression during the early stage of beige adipogenesis. Estradiol 0-9 uncoupling protein 1 Homo sapiens 32-36 30374712-10 2018 However, SPC restored the normal tissue histoarchitecture and also increased the functional efficiency and expression of the ER-alpha receptor by overturning the ES levels in NaF-treated rats. Estradiol 162-164 estrogen receptor 1 Rattus norvegicus 125-133 30184270-6 2018 In addition, the CYP1A1 gene, responsible for the hydroxylation of 17beta-estradiol, estrone, and vitamin D, was also mutated in all three sisters and one unrelated patient. Estradiol 67-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 17-23 30328349-2 2018 miR microarray analysis and multiple confirmatory cell preparations treated with 17beta-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Estradiol 81-97 microRNA let-7c Homo sapiens 128-134 30467368-3 2018 Ovariectomy increased mechanical pain sensitivity and 17beta-estradiol (E2) replacement restored it to basal levels in PMCA2+/+ mice, but not in PMCA2+/- littermates. Estradiol 54-70 ATPase, Ca++ transporting, plasma membrane 2 Mus musculus 119-124 30524376-5 2018 Confocal microscopic and pre-embedding immunohistochemical studies on ovariectomized mice treated with 17beta-estradiol (OVX+E2) provided evidence for direct appositions and asymmetric synapses between GnRH-IR fiber varicosities and TH-IR neurons in the POA and the Arc. Estradiol 103-119 gonadotropin releasing hormone 1 Mus musculus 202-206 30419816-11 2018 The knockdown of IGFBP7 in buffalo granulosa cells promoted cell apoptosis and hindered cell proliferation, and increased the production of progesterone and estradiol. Estradiol 157-166 insulin like growth factor binding protein 7 Bos taurus 17-23 30142332-5 2018 HB-EGF levels increase in response to different forms of injuries as well as stimuli, such as lysophosphatidic acid, retinoic acid, and 17beta-estradiol. Estradiol 136-152 heparin binding EGF like growth factor Homo sapiens 0-6 30226541-0 2018 The role of 17beta-estradiol-induced upregulation of Piwi-like 4 in modulating gene expression and motility in breast cancer cells. Estradiol 12-28 piwi like RNA-mediated gene silencing 4 Homo sapiens 53-64 30417127-5 2018 Breakdown of HER3 and ER were regulated by a ubiquitin ligase Nedd4-1 in the presence of estradiol stimulation. Estradiol 89-98 NEDD4 E3 ubiquitin protein ligase Homo sapiens 62-69 30417127-6 2018 We speculate that estradiol quickly degrades ER, making HER3 accessible by Nedd4-1, and leads to the rapid degradation of HER3. Estradiol 18-27 NEDD4 E3 ubiquitin protein ligase Homo sapiens 75-82 30417127-7 2018 In addition, knockdown of ubiquitin ligase Nedd4-1 enhances estradiol induced cell proliferation. Estradiol 60-69 NEDD4 E3 ubiquitin protein ligase Homo sapiens 43-50 29894929-7 2018 Interestingly, the PhP under study were biodegraded even in the absence of additional carbon source, with 85% of ciprofloxacin removed under sulfate-reducing conditions and 62% and 83% of ciprofloxacin and estradiol removed, respectively, under nitrate-reducing conditions. Estradiol 206-215 N-acylsphingosine amidohydrolase 1 Homo sapiens 19-22 30286578-10 2018 CONCLUSION: High serum estradiol levels increased Glut4 expression and glycogen content in the pubococcygeus muscle, but not in the iliococcygeus muscle. Estradiol 23-32 solute carrier family 2 member 4 Rattus norvegicus 50-55 29789714-3 2018 Mechanism dissection revealed that targeting ERbeta with ERbeta-shRNA and stimulating the transactivation of ERbeta with 17beta-estradiol or environmental endocrine disrupting chemicals, all resulted in altering the lncRNA HOTAIR expression. Estradiol 121-137 HOX transcript antisense RNA Homo sapiens 223-229 29909969-4 2018 Pharmacological and genetic interventions indicate that the hepatic estrogen receptor (ERalpha) has a key role in this sex-related strategy that is primed around birth by the aromatase-dependent conversion of testosterone into estradiol. Estradiol 227-236 estrogen receptor 1 (alpha) Mus musculus 68-85 29909969-4 2018 Pharmacological and genetic interventions indicate that the hepatic estrogen receptor (ERalpha) has a key role in this sex-related strategy that is primed around birth by the aromatase-dependent conversion of testosterone into estradiol. Estradiol 227-236 estrogen receptor 1 (alpha) Mus musculus 87-94 30086159-8 2018 On the other hand, the treatment with estradiol induced an increase in CD-MPR and CatD expression and a re-distribution of both proteins towards the cell periphery. Estradiol 38-47 mannose-6-phosphate receptor, cation dependent Homo sapiens 71-77 29901186-0 2018 Early synergistic interactions between the HPV16-E7 oncoprotein and 17beta-oestradiol for repressing the expression of Granzyme B in a cervical cancer model. Estradiol 68-85 granzyme B Homo sapiens 119-129 30483700-1 2018 PURPOSE: To investigate the role of 17beta-estradiol (E2) and resveratrol dimer (RD) on HIF-1alpha and the underlying mechanism. Estradiol 36-52 hypoxia inducible factor 1, alpha subunit Mus musculus 88-98 30016968-3 2018 Our study aimed to investigate the role of Ube2v1, one of the ubiquitin-conjugating E2 enzyme variant proteins (Ube2v) but without the conserved cysteine residue required for the catalytic activity of E2s, in CRC. Estradiol 201-204 ubiquitin conjugating enzyme E2 V1 Homo sapiens 43-49 29859505-1 2018 The human enzyme 17beta-hydroxysteroid dehydrogenase 14 (17beta-HSD14) oxidizes the hydroxyl group at position 17 of estradiol and 5-androstenediol using NAD+ as cofactor. Estradiol 117-126 hydroxysteroid 17-beta dehydrogenase 14 Homo sapiens 17-55 29859505-1 2018 The human enzyme 17beta-hydroxysteroid dehydrogenase 14 (17beta-HSD14) oxidizes the hydroxyl group at position 17 of estradiol and 5-androstenediol using NAD+ as cofactor. Estradiol 117-126 hydroxysteroid 17-beta dehydrogenase 14 Homo sapiens 57-69 29653184-6 2018 In addition, the levels of p-p38MAPK and p-ERK known to be activated in microglia and p-JNK known to be activated in astrocyte were significantly decreased by 17beta-estradiol. Estradiol 159-175 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 41-46 29665500-3 2018 Reduction of testosterone by aromatase generates proconvulsant 17-beta estradiol. Estradiol 63-80 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 29-38 29807145-7 2018 The P62, caspase-9 and Bax levels were significantly decreased in TDP-25 cells treated with Ral or E2, and the LC3-II levels were elevated in E2-treated cells but reduced in Ral-treated cells. Estradiol 99-101 caspase 9 Homo sapiens 9-18 29603059-8 2018 Moreover, adiponectin reverses the stimulatory effects of 17beta-estradiol and insulin-like growth factor 1 on cell proliferation by downregulating the expression of their receptors, whereas progesterone increased the sensitivity of cancer cells to adiponectin by upregulating AdipoR1 and AdipoR2 expression. Estradiol 58-74 adiponectin receptor 1 Homo sapiens 277-284 29739821-5 2018 Dehydroepiandrosterone (DHEA) treatment caused anovulation, high levels of androgen and estrogen receptors (AR and ER) in the ovary, high expression of CNP and natriuretic peptide receptor 2 (NPR2) in granulosa cells (GC), and an increase in testosterone and estradiol (E2) levels in sera. Estradiol 259-268 natriuretic peptide receptor 2 Mus musculus 192-196 29330129-0 2018 Estradiol up-regulates L-type Ca2+ channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway. Estradiol 0-9 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 81-106 29330129-2 2018 We previously reported that 17beta-estradiol (E2) up-regulates L-type Ca2+ channels and current (ICa,L) (~30%) in rabbit ventricular myocytes by a classic genomic mechanism mediated by estrogen receptor-alpha (ERalpha). Estradiol 28-44 estrogen receptor 1 Rattus norvegicus 210-217 29436590-10 2018 An immunofluorescence staining assay indicated that the co-localization of translocase of mitochondrial outer membrane complex 20 (TOM20) with lysosomal-associated membrane protein 2 (LAMP2) was decreased in INS-1 cells treated with 17beta-E2 alone. Estradiol 239-242 lysosomal-associated membrane protein 2 Rattus norvegicus 143-182 29436590-10 2018 An immunofluorescence staining assay indicated that the co-localization of translocase of mitochondrial outer membrane complex 20 (TOM20) with lysosomal-associated membrane protein 2 (LAMP2) was decreased in INS-1 cells treated with 17beta-E2 alone. Estradiol 239-242 lysosomal-associated membrane protein 2 Rattus norvegicus 184-189 29649501-8 2018 Further, while EE2 and estradiol did not form covalent adducts with DNA, they affected BaP-derived DNA adduct formations in vivo and in vitro. Estradiol 23-32 prohibitin 2 Rattus norvegicus 87-90 29649501-9 2018 The observed decrease in BaP-DNA adduct levels in rat liver in vivo resulted from the inhibition of CYP1A1-mediated BaP bioactivation by EE2 and estradiol. Estradiol 145-154 prohibitin 2 Rattus norvegicus 25-28 29649501-9 2018 The observed decrease in BaP-DNA adduct levels in rat liver in vivo resulted from the inhibition of CYP1A1-mediated BaP bioactivation by EE2 and estradiol. Estradiol 145-154 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 100-106 29649501-9 2018 The observed decrease in BaP-DNA adduct levels in rat liver in vivo resulted from the inhibition of CYP1A1-mediated BaP bioactivation by EE2 and estradiol. Estradiol 145-154 prohibitin 2 Rattus norvegicus 116-119 29649501-10 2018 Our results indicate that BaP genotoxicity mediated through its activation by CYP1A1 in rats in vivo is modulated by estradiol and its synthetic derivative EE2. Estradiol 117-126 prohibitin 2 Rattus norvegicus 26-29 29649501-10 2018 Our results indicate that BaP genotoxicity mediated through its activation by CYP1A1 in rats in vivo is modulated by estradiol and its synthetic derivative EE2. Estradiol 117-126 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 78-84 29686616-5 2018 We demonstrated that estradiol treatment of adult PA exposed animals induced an increase in estrogen receptor (ER) alpha and insulin-like growth factor receptor (IGF-1R) protein levels, an activation of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 beta/beta-catenin signaling pathway and an increase in Bcl-2/Bax ratio in the hippocampus in comparison to PA exposed animals treated with vehicle. Estradiol 21-30 catenin beta 1 Homo sapiens 273-285 29288569-9 2018 The 17beta-oestradiol-oriented enhancement of CD86 expression on CD103+ DCs after allergen exposure induced the enhanced IL-5 production from CD4+ T cells. Estradiol 4-21 interleukin 5 Mus musculus 121-125 28466267-0 2018 17beta-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication. Estradiol 0-16 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 34-37 28466267-0 2018 17beta-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication. Estradiol 0-16 nuclear factor kappa B subunit 1 Rattus norvegicus 38-43 29169115-13 2018 Also, cell migration of EBF1-knockdown cells was significantly enhanced after 17beta-estradiol treatment. Estradiol 78-94 EBF transcription factor 1 Homo sapiens 24-28 29594259-0 2018 17beta-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes. Estradiol 0-16 signal transducer and activator of transcription 5A Mus musculus 56-61 29594259-4 2018 In this study, we examined the effect of two estrogenic ligands, 17beta-estradiol (E2) and the clinical antiestrogen, ICI182,780 (ICI, fulvestrant) on expression of STAT5 isoforms and resulting crosstalk with PRL in normal and tumor murine mammary epithelial cell lines. Estradiol 65-81 signal transducer and activator of transcription 5A Mus musculus 165-170 28529128-2 2018 The primary physiological estrogen 17beta-estradiol (E2), a non-selective agonist of classical nuclear estrogen receptors (ERalpha and ERbeta) as well as the G protein-coupled estrogen receptor (GPER), stimulates formation of the vasodilator nitric oxide (NO) in endothelial cells. Estradiol 35-51 estrogen receptor 1 (alpha) Mus musculus 123-130 29422866-7 2018 In the ovariectomized mice, the expression of uterine NBCn1 is inhibited by beta-estradiol, but stimulated by progesterone, whereas that of uterine SLC26A4/A6 is stimulated by beta-estradiol. Estradiol 176-190 solute carrier family 26, member 4 Mus musculus 148-155 29362726-9 2018 Estradiol restored the ERbeta mRNA levels and number of serotonergic cells in the DRN caudal subregion. Estradiol 0-9 estrogen receptor 2 Rattus norvegicus 23-29 29362726-10 2018 The 5-HT levels were lower in the AMY and HPC in peristropausal rats, and estradiol treatment increased the 5-HT levels in the HPC and also increased ERbeta expression in this area. Estradiol 74-83 estrogen receptor 2 Rattus norvegicus 150-156 29362726-11 2018 In conclusion, estradiol may improve perimenopause symptoms by increasing progesterone and boosting serotonin pathway from the caudal DRN to the dorsal HPC potentially through an increment in ERbeta expression in the DRN. Estradiol 15-24 estrogen receptor 2 Rattus norvegicus 192-198 28835435-7 2018 Moreover, the steroid hormones estradiol and progesterone decreased miR-15b expression with a subsequent increase in lipid formation in mammary epithelial cells. Estradiol 31-40 microRNA 15b Mus musculus 68-75 29150243-5 2018 Both NCG and ARG inhibited (P<0.05) IGF1- and FSH-induced GC estradiol production but only NCG inhibited (P<0.05) progesterone production. Estradiol 64-73 insulin like growth factor 1 Bos taurus 39-43 30616396-7 2018 High Atlas Moroccans and Algerians show low frequency of UGT2B17del, a variant associated with high concentrations of testosterone and oestradiol. Estradiol 135-145 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 57-64 29763890-12 2018 Consistently, miR-301a-3p causes a decrease in sensitivity of MCF7 cells to 17beta-estradiol and inhibits the growth of estrogen dependent tumor in nude mice. Estradiol 76-92 microRNA 301a Homo sapiens 14-22 29069304-6 2018 Targeted extracellular recordings were used to record firing activity from green fluorescent protein-identified GnRH neurons in brain slices before and during CRH treatment; recordings were done in the afternoon when estradiol has a positive feedback effect to increase GnRH neuron firing. Estradiol 217-226 gonadotropin releasing hormone 1 Mus musculus 270-274 29069304-11 2018 These results indicate that CRH alters GnRH neuron activity and that estradiol is required for CRH to exert both stimulatory and inhibitory effects on GnRH neurons. Estradiol 69-78 gonadotropin releasing hormone 1 Mus musculus 151-155 29054710-1 2017 The female hormone 17 beta-estradiol (E2) is synthesized from estrone by steroid sulfatase (STS), and metabolized into 2-methoxyestradiol (2-ME), whereby the biological activity of the latter is substantially different from that of E2. Estradiol 19-36 steroid sulfatase Homo sapiens 73-90 29055020-9 2017 In contrast, TAF in MED12-LM proliferated in response to estradiol, whereas progesterone had no effect. Estradiol 57-66 mediator complex subunit 12 Homo sapiens 20-25 29255797-6 2017 Moreover, communication processing in NCM is rapidly enhanced by local 17beta-estradiol (E2) administration in adult songbirds; however, the function of dynamically fluctuating E2 in NCM during development is unknown. Estradiol 71-87 CWC22 spliceosome associated protein homolog Homo sapiens 38-41 29255797-6 2017 Moreover, communication processing in NCM is rapidly enhanced by local 17beta-estradiol (E2) administration in adult songbirds; however, the function of dynamically fluctuating E2 in NCM during development is unknown. Estradiol 89-91 CWC22 spliceosome associated protein homolog Homo sapiens 38-41 28888115-8 2017 In the absence of IGF1 but presence of FSH, 1 mug/mL of G-RU decreased (P < 0.05) estradiol production, whereas in the presence of IGF1 and FSH, 1 mug/mL of G-RU increased (P < 0.05) cell numbers, progesterone and estradiol production. Estradiol 220-229 insulin like growth factor 1 Bos taurus 134-138 28888115-10 2017 3, IGF1 significantly increased cell numbers (by 2.8-fold) and estradiol (by 17.8-fold) and progesterone (by 6.1-fold) production. Estradiol 63-72 insulin like growth factor 1 Bos taurus 3-7 28940538-5 2017 Here we show that the level of oestradiol is dramatically elevated, concomitant with significant upregulation of oestrogen response genes, in prostatic samples with methylation at the SRD5A2 promoter. Estradiol 31-41 steroid 5 alpha-reductase 2 Homo sapiens 184-190 29550797-9 2017 The increased MPO levels were inhibited with PPT in male pancreas and female lung and with 17beta-estradiol in female pancreas (P < 0.05). Estradiol 91-107 myeloperoxidase Rattus norvegicus 14-17 29299128-6 2017 Results: Aortic tissue from OVX mice exhibited marked VSMC hyperplasia and upregulation of SIRT1, which was reversed by 17-beta-estradiol supplementation, as assessed by western blotting and immunohistochemical staining. Estradiol 120-137 sirtuin 1 Mus musculus 91-96 29299128-7 2017 In vitro, 17-beta-estradiol downregulated SIRT1 expression in a dose- and time-dependent manner, increased apoptosis, and reduced proliferation, viability, and migration. Estradiol 10-27 sirtuin 1 Mus musculus 42-47 29096715-7 2017 RESULTS: 17beta-estradiol at 1 muM downregulated vimentin and CD13 and upregulated cytokeratin and CD9 proteins, promoting the differentiation of WJ-MSCs into EEC-like cells in the coculture system. Estradiol 9-25 vimentin Homo sapiens 49-57 28758225-8 2017 CYP2C9.38 showed higher activities in testosterone 6beta-hydroxylation, progesterone 6beta-/16alpha-hydroxylation, estrone 11alpha-hydroxylation and estradiol 6alpha-hydroxylation than CYP2C9.1. Estradiol 149-158 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 0-6 28938484-8 2017 HCG26 was knocked down with locked nucleic acid GapmeRs in KGN cells to examine its role in cell proliferation, aromatase and follicle-stimulating hormone receptor gene expression, and estradiol production. Estradiol 185-194 HLA complex group 26 Homo sapiens 0-5 28938480-2 2017 Objective: The aim of the study was to compare the regulation of the AMH/AMHR2 system by 5alpha-dihydrotestosterone (5alpha-DHT) and estradiol (E2) in GCs from control subjects and women with PCOS. Estradiol 133-142 anti-Mullerian hormone Homo sapiens 69-72 28388831-12 2017 Both treadmill training and estradiol administration increased the number of motoneurons participating in axon regeneration, but these effects were blocked by ER antagonist treatment. Estradiol 28-37 estrogen receptor 1 (alpha) Mus musculus 159-161 28442026-4 2017 Oestradiol in the ganglion decreased ovarian P4, E2 and NA release, as well as 3beta-HSD activity, but increased the release of A2 and nitrites, as well as the 20alpha-HSD expression and its activity. Estradiol 0-10 solute carrier family 10 member 4 Homo sapiens 45-66 29158795-8 2017 The effect of hMLH1 overexpression in LoVo cells resulted in a similar increase in apoptosis that was greatly stimulated by estradiol. Estradiol 124-133 mutL homolog 1 Homo sapiens 14-19 29158795-9 2017 The enhanced apoptosis by hMLH1 and estradiol was further validated by FACS analyses of Annexin V expression. Estradiol 36-45 annexin A5 Homo sapiens 88-97 28911176-2 2017 Aromatase (encoded by CYP19) catalyzes the final step of estradiol biosynthesis. Estradiol 57-66 cytochrome P450, family 19, subfamily A, polypeptide 1a Danio rerio 22-27 28529127-0 2017 Antioxidant peroxiredoxin 3 expression is regulated by 17beta-estradiol in rat white adipose tissue. Estradiol 55-71 peroxiredoxin 3 Rattus norvegicus 12-27 28656272-1 2017 Our previous demonstrated that macrophage colony-stimulating factor (M-CSF) stimulated the production of estradiol (E2) and progesterone (P) in luteinized granulosa cells (GCs), and that its secretion may be regulated by follicle-stimulating hormone (FSH). Estradiol 105-114 colony stimulating factor 1 Homo sapiens 31-67 28656272-1 2017 Our previous demonstrated that macrophage colony-stimulating factor (M-CSF) stimulated the production of estradiol (E2) and progesterone (P) in luteinized granulosa cells (GCs), and that its secretion may be regulated by follicle-stimulating hormone (FSH). Estradiol 105-114 colony stimulating factor 1 Homo sapiens 69-74 28468943-0 2017 Estradiol activates chloride channels via estrogen receptor-alpha in the cell membranes of osteoblasts. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 42-65 28468943-8 2017 The selective ERalpha agonist, but not ERbeta agonist, activated a Cl- current similar to that induced by 17beta-estradiol. Estradiol 106-122 estrogen receptor 1 (alpha) Mus musculus 14-21 28743985-2 2017 17beta-estradiol (E2) also influences hypothalamic programming through estrogen receptor (ER) alpha. Estradiol 0-16 estrogen receptor 1 (alpha) Mus musculus 71-99 28624805-3 2017 Here we showed that the ability of Rcan2 to promote weight gain was attenuated by energy expenditure mediated by 17beta-estradiol in female mice. Estradiol 113-129 regulator of calcineurin 2 Mus musculus 35-40 28624805-4 2017 Using ovariectomy-operated models, we found that 17beta-estradiol deprivation did not alter food intake, but induced more weight gain in wild-type mice than Rcan2-/- mice. Estradiol 49-65 regulator of calcineurin 2 Mus musculus 157-162 28708846-5 2017 The effect of 17beta-estradiol on fibrillin-1 protein synthesis was compared in vitro using human aortic smooth muscle cells and fibroblasts. Estradiol 14-30 fibrillin 1 Homo sapiens 34-45 28708846-11 2017 In addition, 17beta-estradiol was found to promote fibrillin-1 production by human aortic smooth muscle cells. Estradiol 13-29 fibrillin 1 Homo sapiens 51-62 27826093-7 2017 RESULTS: Hsp90 release was stimulated with optimal doses of estradiol, IL-1, and TNF-alpha (10 ng/mL) from 15 minutes to 120 minutes. Estradiol 60-69 heat shock protein 90 alpha family class A member 1 Homo sapiens 9-14 28649090-7 2017 Furthermore, our results demonstrated that miR-143 acts as a negative regulating molecule mediating the signaling pathway of FSH and affecting estradiol production by targeting KRAS. Estradiol 143-152 microRNA 143 Mus musculus 43-50 28649090-7 2017 Furthermore, our results demonstrated that miR-143 acts as a negative regulating molecule mediating the signaling pathway of FSH and affecting estradiol production by targeting KRAS. Estradiol 143-152 Kirsten rat sarcoma viral oncogene homolog Mus musculus 177-181 28649090-9 2017 These findings indicate that miR-143 plays vital roles in FSH-induced estradiol production and granulosa cell proliferation, providing a novel mechanism that involves miRNA in regulating granulosa cell functions. Estradiol 70-79 microRNA 143 Mus musculus 29-36 28582470-12 2017 RESULTS: Upregulation of Nav1.7 in TG and decrease in head withdrawal threshold were observed with the highest plasma 17beta-estradiol in the proestrus of female rats. Estradiol 118-134 sodium voltage-gated channel alpha subunit 9 Rattus norvegicus 25-31 28582470-13 2017 Ovariectomized rats treated with 80 mug 17beta-estradiol showed upregulation of Nav1.7 in TG and decrease in head withdrawal threshold as compared with that of the control or ovariectomized rats treated with 0 mug or 20 mug. Estradiol 40-56 sodium voltage-gated channel alpha subunit 9 Rattus norvegicus 80-86 28582470-14 2017 Moreover, 17beta-estradiol dose-dependently potentiated TMJ inflammation-induced upregulation of Nav1.7 in TG and also enhanced TMJ inflammation-induced decrease of head withdrawal threshold in ovariectomized rats. Estradiol 10-26 sodium voltage-gated channel alpha subunit 9 Rattus norvegicus 97-103 28582470-15 2017 In addition, the estrogen receptor antagonist, ICI 182,780, partially blocked the 17beta-estradiol effect on Nav1.7 expression and head withdrawal threshold in ovariectomized rats. Estradiol 82-98 sodium voltage-gated channel alpha subunit 9 Rattus norvegicus 109-115 28582470-17 2017 In the nerve growth factor-induced and ERalpha-transfected PC12 cells, 17beta-estradiol dose-dependently enhanced Nav1.7 promoter activity, whereas mutations of the estrogen response element at -1269/-1282 and -1214/-1227 in the promoter completely abolished its effect on the promoter activity. Estradiol 71-87 estrogen receptor 1 Rattus norvegicus 39-46 28582470-17 2017 In the nerve growth factor-induced and ERalpha-transfected PC12 cells, 17beta-estradiol dose-dependently enhanced Nav1.7 promoter activity, whereas mutations of the estrogen response element at -1269/-1282 and -1214/-1227 in the promoter completely abolished its effect on the promoter activity. Estradiol 71-87 sodium voltage-gated channel alpha subunit 9 Rattus norvegicus 114-120 28502695-2 2017 We recently found that the protection conferred by 17beta-estradiol against obesity and insulin resistance requires ERalpha-AF2 but not ERalpha-AF1. Estradiol 51-67 estrogen receptor 1 (alpha) Mus musculus 116-123 28498246-10 2017 While MEK inhibition blocked estradiol-stimulated phosphorylation of ERK1/2 and p90RSK in wild-type cells, phospho-ERK1/2 and phospho-p90RSK were substantially increased in KRas mutants. Estradiol 29-38 ribosomal protein S6 kinase A1 Homo sapiens 80-86 28498246-10 2017 While MEK inhibition blocked estradiol-stimulated phosphorylation of ERK1/2 and p90RSK in wild-type cells, phospho-ERK1/2 and phospho-p90RSK were substantially increased in KRas mutants. Estradiol 29-38 ribosomal protein S6 kinase A1 Homo sapiens 134-140 28388333-9 2017 17-beta estradiol correlated moderately and negatively with Mb relative change (r = -.52, p < .05). Estradiol 0-17 myoglobin Homo sapiens 60-62 28360090-9 2017 17beta-estradiol treatment of castrated male mice also strongly protected them from ischemic necrosis through the activation of estrogen receptor-alpha by increasing skin revascularization and skin survival. Estradiol 0-16 estrogen receptor 1 (alpha) Mus musculus 128-151 28319389-1 2017 17beta-Hydroxysteroid dehydrogenase type 2 (17beta-HSD2) converts the active steroid hormones estradiol, testosterone, and 5alpha-dihydrotestosterone into their weakly active forms estrone, Delta4-androstene-3,17-dione, and 5alpha-androstane-3,17-dione, respectively, thereby regulating cell- and tissue-specific steroid action. Estradiol 94-103 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 0-55 28100475-5 2017 Both moderate and high-volume exercise were able to reduce body fat and increase the mRNA and protein expression of LEP-JAK-STAT, but only moderate exercise significantly increased the mRNA and protein expression of steroidogenic factor-1, steroidogenic acute regulatory protein, and P-450 side-chain cleavage enzyme and significantly reversed the serum testosterone-to-estradiol ratio and sperm quality parameters. Estradiol 370-379 leptin Mus musculus 116-119 28040605-13 2017 6 and 7, 2 presumed ligands of GPR34, L-a-lysophosphatidylserine (LPPS) and LPP-ethanolamine, increased (P < 0.05) GC numbers and estradiol production by 2-fold or more in small-follicle GC, and this response was only observed in IGF1-treated GC. Estradiol 133-142 G-protein-coupled receptor GPR34 Bos taurus 31-36 28382233-8 2017 On the contrary, fatty acid binding protein 4 was upregulated (2.66-fold) after the administration of the combination of 17beta-estradiol and oxytocin. Estradiol 121-137 fatty acid binding protein 4 Homo sapiens 17-45 28529452-0 2017 Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1. Estradiol 0-9 toll like receptor 4 Homo sapiens 21-25 28357125-10 2017 In human cell lines H1299 and H1395, treatment with estradiol (10 and 100 nmol/L) significantly reduced expression of CYP1A2. Estradiol 52-61 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 118-124 28063803-1 2017 In the female rat, sexual receptivity (lordosis) can be facilitated by sequential activation of estrogen receptor (ER) alpha and G protein-coupled estrogen receptor 1 (GPER) by estradiol. Estradiol 177-186 estrogen receptor 1 Rattus norvegicus 96-124 28063803-1 2017 In the female rat, sexual receptivity (lordosis) can be facilitated by sequential activation of estrogen receptor (ER) alpha and G protein-coupled estrogen receptor 1 (GPER) by estradiol. Estradiol 177-186 G protein-coupled estrogen receptor 1 Rattus norvegicus 129-166 28063803-1 2017 In the female rat, sexual receptivity (lordosis) can be facilitated by sequential activation of estrogen receptor (ER) alpha and G protein-coupled estrogen receptor 1 (GPER) by estradiol. Estradiol 177-186 G protein-coupled estrogen receptor 1 Rattus norvegicus 168-172 28063803-4 2017 Infusion of non-esterified 17beta-estradiol into the ARH rapidly reduces MPN MOP activation and facilitates lordosis via GPER. Estradiol 27-43 G protein-coupled estrogen receptor 1 Rattus norvegicus 121-125 28077306-2 2017 Isoflavones, the most common phytoestrogens, have a similar structure and molecular weight to 17beta-estradiol (E2) and have the ability to bind and activate both isoforms of the estrogen receptor (ER). Estradiol 94-110 estrogen receptor 1 Rattus norvegicus 179-196 28077306-2 2017 Isoflavones, the most common phytoestrogens, have a similar structure and molecular weight to 17beta-estradiol (E2) and have the ability to bind and activate both isoforms of the estrogen receptor (ER). Estradiol 94-110 estrogen receptor 1 Rattus norvegicus 198-200 27870444-6 2017 Neonatal administration of exogenous estradiol resulted in opposite effects on BDNF expression in these areas of the neonatal hippocampus, such that BDNF transcripts increased in CA1 but decreased in dentate. Estradiol 37-46 carbonic anhydrase 1 Rattus norvegicus 179-182 27793723-10 2017 The expression levels of MRAP in chicken liver were significantly increased at sexual maturity stage, and were significantly up-regulated (P<0.05) when chickens and chicken primary hepatocytes were treated with 17beta-estradiol in vivo and in vitro, respectively; however, expression levels of PPARgamma were down-regulated, and no effect on MC5R was observed. Estradiol 214-230 melanocortin 2 receptor accessory protein Gallus gallus 25-29 27815062-7 2017 There were almost twicethe levels of AMH and 17beta-oestradiol in treated compared with untreated samples (AMH with 4hc 3 micromol/l; P = 0.04). Estradiol 45-62 anti-Mullerian hormone Homo sapiens 107-110 28078025-12 2016 Probe substrates Estradiol-17 beta-glucuronide was incubated in HEK293-OATP1B1 and HEK293-MOCK cell system with different concentration of SBP and estimated IC50 was 179 mug/mL, which demonstrated a moderate inhibition potential against OATP1B1. Estradiol 17-26 solute carrier organic anion transporter family member 1B1 Homo sapiens 71-78 28078025-12 2016 Probe substrates Estradiol-17 beta-glucuronide was incubated in HEK293-OATP1B1 and HEK293-MOCK cell system with different concentration of SBP and estimated IC50 was 179 mug/mL, which demonstrated a moderate inhibition potential against OATP1B1. Estradiol 17-26 solute carrier organic anion transporter family member 1B1 Homo sapiens 237-244 28032117-2 2016 Although these enhancements are traditionally thought to be due to circulating estradiol, recent data suggest these changes are brought on by hippocampus-derived estradiol, the synthesis of which depends on gonadotropin-releasing hormone (GnRH) activity. Estradiol 162-171 gonadotropin releasing hormone 1 Rattus norvegicus 207-237 28032117-2 2016 Although these enhancements are traditionally thought to be due to circulating estradiol, recent data suggest these changes are brought on by hippocampus-derived estradiol, the synthesis of which depends on gonadotropin-releasing hormone (GnRH) activity. Estradiol 162-171 gonadotropin releasing hormone 1 Rattus norvegicus 239-243 28032117-7 2016 Results indicate that peripheral estradiol-induced enhancement of cognition is mediated by brain-derived estradiol via hippocampal GnRH receptor activity. Estradiol 33-42 gonadotropin releasing hormone 1 Rattus norvegicus 131-135 28032117-7 2016 Results indicate that peripheral estradiol-induced enhancement of cognition is mediated by brain-derived estradiol via hippocampal GnRH receptor activity. Estradiol 105-114 gonadotropin releasing hormone 1 Rattus norvegicus 131-135 27507595-1 2016 Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17beta-estradiol (E2) on the HPG axis. Estradiol 122-138 tachykinin 2 Mus musculus 65-69 27771246-8 2016 Mechanistically, E2 restored the inhibited expression of Gas6 and phospho-Akt in Pi-induced apoptosis through ERalpha. Estradiol 17-19 growth arrest specific 6 Homo sapiens 57-61 27566061-9 2016 The data show an estradiol-induced temporal association between kisspeptin increase in the POA and GnRH/LH surges. Estradiol 17-26 gonadotropin releasing hormone 1 Rattus norvegicus 99-103 26403213-13 2016 Finally, the expression of AMH and genes co-expressed with AMH (AMHR2, ESR2 and FSHR) in granulosa cells as well as intrafollicular AMH concentrations decreased during follicular development while intrafollicular oestradiol concentrations increased and were inversely related to intrafollicular AMH concentrations. Estradiol 213-223 anti-Mullerian hormone receptor type 2 Equus caballus 27-30 26403213-13 2016 Finally, the expression of AMH and genes co-expressed with AMH (AMHR2, ESR2 and FSHR) in granulosa cells as well as intrafollicular AMH concentrations decreased during follicular development while intrafollicular oestradiol concentrations increased and were inversely related to intrafollicular AMH concentrations. Estradiol 213-223 anti-Mullerian hormone receptor type 2 Equus caballus 59-62 26403213-13 2016 Finally, the expression of AMH and genes co-expressed with AMH (AMHR2, ESR2 and FSHR) in granulosa cells as well as intrafollicular AMH concentrations decreased during follicular development while intrafollicular oestradiol concentrations increased and were inversely related to intrafollicular AMH concentrations. Estradiol 213-223 anti-Mullerian hormone receptor type 2 Equus caballus 59-62 26403213-13 2016 Finally, the expression of AMH and genes co-expressed with AMH (AMHR2, ESR2 and FSHR) in granulosa cells as well as intrafollicular AMH concentrations decreased during follicular development while intrafollicular oestradiol concentrations increased and were inversely related to intrafollicular AMH concentrations. Estradiol 213-223 anti-Mullerian hormone receptor type 2 Equus caballus 59-62 27255147-8 2016 Taken together, our results, for the first time, show that in ovarian cancer cells ObR+/ER+, 17beta-estradiol has an antagonistic effect on leptin-induced cell migration as well as MMP-9 expression and activity, which is mediated by the PI3K pathway. Estradiol 93-109 leptin receptor Homo sapiens 83-86 27207475-2 2016 Thus, the hypothesis of this experiment is that insulin concentration and the form of FSH addition affect the in vitro survival, growth, and estradiol production after culture of isolated bovine preantral follicles. Estradiol 141-150 insulin Bos taurus 48-55 27165169-0 2016 Gastric 17beta-estradiol in portal vein and liver Esr1 make a circadian rhythm in systemic circulation in male rats. Estradiol 8-24 estrogen receptor 1 Rattus norvegicus 50-54 27198138-8 2016 Groups III and IV (Ovx +17beta-estradiol and Ovx + bortezomib) showed decreased NF-kB/p65 and caspase-3 expression compared with the Ovx group (p < 0.05). Estradiol 24-40 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 80-85 27082697-9 2016 Treatment with 17beta-estradiol (E2) significantly weakened the proliferative ability of the cells derived from the OVX group rats, and enhanced their osteogenic differentiation ability and the mRNA expression levels of ALP, OCN, ERalpha and ERbeta. Estradiol 15-31 estrogen receptor 1 Rattus norvegicus 230-237 27082697-9 2016 Treatment with 17beta-estradiol (E2) significantly weakened the proliferative ability of the cells derived from the OVX group rats, and enhanced their osteogenic differentiation ability and the mRNA expression levels of ALP, OCN, ERalpha and ERbeta. Estradiol 15-31 estrogen receptor 2 Rattus norvegicus 242-248 27188489-30 2016 Estrogen (17beta-estradiol) can promote the proliferation of HaCaT cells by increasing the expression of PCNA via activating ERK/Akt signaling pathway. Estradiol 10-26 proliferating cell nuclear antigen Homo sapiens 105-109 26962117-6 2016 Uteri of Arid1a knockout mice showed a normal decidualization response and appropriate responses to estradiol and progesterone stimulation. Estradiol 100-109 AT rich interactive domain 1A (SWI-like) Mus musculus 9-15 26808975-9 2016 During the regenerative period of the oviduct after molting, expression of AQP3 mRNA increased coordinately with increasing concentrations of estradiol (P < 0.001), whereas expression of AQP3 mRNA decreased as concentrations of estradiol in plasma decreased in response to induced molting (P < 0.001). Estradiol 142-151 aquaporin 3 Gallus gallus 75-79 27358124-7 2016 It can be concluded that estradiol is able to promote the proliferation of osteoblasts in mice by ERalpha-mediated Wnt/beta-catenin signaling pathway. Estradiol 25-34 estrogen receptor 1 (alpha) Mus musculus 98-105 25427133-8 2016 Specifically, oestradiol, when combined with IGF-1, insulin and FSH, stimulated HAS2 mRNA expression. Estradiol 14-24 hyaluronan synthase 2 Ovis aries 80-84 27066533-1 2016 Testosterone, after being converted to estradiol in the brain, acts on estrogen receptors (ERalpha and ERbeta) and controls the expression of male-type social behavior. Estradiol 39-48 estrogen receptor 1 (alpha) Mus musculus 91-98 27028912-6 2016 RESULTS: After a median of 5 years, the effect of estradiol, with or without progesterone, on CIMT progression differed between the early and late postmenopause strata (P=0.007 for the interaction). Estradiol 50-59 CIMT Homo sapiens 94-98 27028912-10 2016 CONCLUSIONS: Oral estradiol therapy was associated with less progression of subclinical atherosclerosis (measured as CIMT) than was placebo when therapy was initiated within 6 years after menopause but not when it was initiated 10 or more years after menopause. Estradiol 18-27 CIMT Homo sapiens 117-121 27127723-0 2016 GPER expressed on microglia mediates the anti-inflammatory effect of estradiol in ischemic stroke. Estradiol 69-78 G protein-coupled estrogen receptor 1 Rattus norvegicus 0-4 27127723-4 2016 We hypothesize that the anti-inflammatory and neuroprotective effect of estradiol is mediated by the estradiol receptor G protein-coupled estrogen receptor 1 (GPER) expressed on microglia. Estradiol 72-81 G protein-coupled estrogen receptor 1 Rattus norvegicus 159-163 27127723-9 2016 Moreover, the specific GPER antagonist G15 was able to abolish the anti-inflammatory effect of estradiol. Estradiol 95-104 G protein-coupled estrogen receptor 1 Rattus norvegicus 23-27 26891996-5 2016 In astrocytes, 2.5-20 nM 17beta-estradiol (E2) or 10 nM DPN (ERbeta agonist) not 10 nM PPT (ERalpha agonist), significantly increased GFAP expression. Estradiol 25-41 glial fibrillary acidic protein Mus musculus 134-138 26577678-0 2016 Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17beta-estradiol. Estradiol 132-148 neuropeptide Y Homo sapiens 82-85 26271031-0 2016 Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking. Estradiol 0-9 potassium voltage-gated channel subfamily H member 2 Homo sapiens 90-95 26271031-10 2016 The heat-shock protein-90 (Hsp90) inhibitor geldanamycin abolished estradiol-induced increase in IKCNH2. Estradiol 67-76 heat shock protein 90 alpha family class A member 1 Homo sapiens 4-25 26271031-10 2016 The heat-shock protein-90 (Hsp90) inhibitor geldanamycin abolished estradiol-induced increase in IKCNH2. Estradiol 67-76 heat shock protein 90 alpha family class A member 1 Homo sapiens 27-32 26271031-12 2016 Estradiol enhanced the physical interaction of KCNH2-channel subunits with heat-shock proteins and augmented ion-channel trafficking to the membrane. Estradiol 0-9 potassium voltage-gated channel subfamily H member 2 Homo sapiens 47-52 26271031-14 2016 Estradiol acts on KCNH2 channels via enhanced estradiol-receptor-alpha-mediated Hsp90 interaction, augments membrane trafficking and thereby increases repolarizing current. Estradiol 0-9 potassium voltage-gated channel subfamily H member 2 Homo sapiens 18-23 26271031-14 2016 Estradiol acts on KCNH2 channels via enhanced estradiol-receptor-alpha-mediated Hsp90 interaction, augments membrane trafficking and thereby increases repolarizing current. Estradiol 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 80-85 26562263-10 2016 An estrogen receptor-alpha agonist but not an estrogen receptor-beta agonist mimicked the effects of estradiol on NK3R activation. Estradiol 101-110 estrogen receptor 1 (alpha) Mus musculus 3-26 26490364-6 2016 Silencing of ER-beta attenuated 17beta-estradiol mediated decrease in caspase 1, ASC, and IL-1beta. Estradiol 32-48 estrogen receptor 2 Rattus norvegicus 13-20 26597778-4 2016 As an antagonist, tamoxifen partially inhibited the estradiol-dependent increase in the number of PR-immunoreactive neurons and in PR mRNA and protein levels, without interfering with the subcellular location of the protein. Estradiol 52-61 progesterone receptor Rattus norvegicus 98-100 26597778-4 2016 As an antagonist, tamoxifen partially inhibited the estradiol-dependent increase in the number of PR-immunoreactive neurons and in PR mRNA and protein levels, without interfering with the subcellular location of the protein. Estradiol 52-61 progesterone receptor Rattus norvegicus 131-133 26597778-5 2016 We suggest that tamoxifen influence on PR expression in the VMNvl critically depends on the presence or absence of estradiol. Estradiol 115-124 progesterone receptor Rattus norvegicus 39-41 26938432-6 2016 Western blot analysis demonstrated the activation of Akt, Erk and upregulation of PCNA in HaCaT cells treated with 17 beta-estradiol. Estradiol 115-132 proliferating cell nuclear antigen Homo sapiens 82-86 26938432-8 2016 Upregulation of PCNA expression, elevated proliferation and high S phase fraction of HaCaT cell by 17 beta-estradiol could be reversed by an Akt or Erk inhibitor. Estradiol 99-116 proliferating cell nuclear antigen Homo sapiens 16-20 26490113-2 2016 Previous studies demonstrated an important role for cocaine- and amphetamine-regulated transcript (CART) in regulation of granulosa cell estradiol production associated with dominant follicle selection in cattle. Estradiol 137-146 CART prepropeptide Bos taurus 52-97 26490113-2 2016 Previous studies demonstrated an important role for cocaine- and amphetamine-regulated transcript (CART) in regulation of granulosa cell estradiol production associated with dominant follicle selection in cattle. Estradiol 137-146 CART prepropeptide Bos taurus 99-103 26490113-7 2016 CART treatment inhibited follicle stimulating hormone-induced estradiol production by cultured ovine granulosal cells and also blocked the follicle stimulating hormone-induced increase in granulosa cell numbers. Estradiol 62-71 CART prepropeptide Bos taurus 0-4 26556532-4 2016 In control rats, the estradiol-induced LH surge at 17 hours was associated with a significant increase in GnRH and kisspeptin content in the median eminence with the increase in kisspeptin preceding that of GnRH and LH. Estradiol 21-30 gonadotropin releasing hormone 1 Rattus norvegicus 106-110 26556532-4 2016 In control rats, the estradiol-induced LH surge at 17 hours was associated with a significant increase in GnRH and kisspeptin content in the median eminence with the increase in kisspeptin preceding that of GnRH and LH. Estradiol 21-30 gonadotropin releasing hormone 1 Rattus norvegicus 207-211 26422138-1 2016 BACKGROUND/AIMS: The contributions of the three principal ovarian steroid hormones (estradiol, progesterone and testosterone) to the regulation of estrogen receptor alpha (ERalpha) levels in the rat brain were examined during the estrous cycle. Estradiol 84-93 estrogen receptor 1 Rattus norvegicus 172-179 27843532-0 2016 NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17beta-Estradiol. Estradiol 92-108 NLR family, pyrin domain containing 3 Mus musculus 0-5 26441237-0 2015 17beta-Estradiol Enhances ASIC Activity in Primary Sensory Neurons to Produce Sex Difference in Acidosis-Induced Nociception. Estradiol 0-16 acid sensing ion channel subunit 1 Homo sapiens 26-30 26442993-0 2015 Reduction in Abeta-induced cell death in the hippocampus of 17beta-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone. Estradiol 60-76 insulin-like growth factor 1 Rattus norvegicus 131-136 26442993-5 2015 Activation of leptin and IGF-I pathways increased after E2 co-administration, and this correlated with changes in the somatostatinergic system. Estradiol 56-58 insulin-like growth factor 1 Rattus norvegicus 25-30 26442993-8 2015 Our results suggest that the E2-induced reduction in cell death is related to lower Abeta levels, probably because of IGF-I and somatostatin modulation of Abeta proteases. Estradiol 29-31 insulin-like growth factor 1 Rattus norvegicus 118-123 26442993-10 2015 E2 co-administration prevents Abeta-produced depletion of hippocampal somatostatin (SRIF) by an IGF-I-mediated mechanism, being related this protective effect with an increase in Abeta proteases. Estradiol 0-2 insulin-like growth factor 1 Rattus norvegicus 96-101 26432349-0 2015 Estradiol promotes cells invasion by activating beta-catenin signaling pathway in endometriosis. Estradiol 0-9 catenin beta 1 Homo sapiens 48-60 26432349-4 2015 beta-catenin expression and cells invasiveness ability were up-regulated by 17beta-estradiol (E2) in an estrogen receptor (ESR)-dependent manner, whereas beta-catenin siRNA abrogated this phenomenon. Estradiol 76-92 catenin beta 1 Homo sapiens 0-12 26476183-3 2015 In this study we report that treatment of endothelial cells (ECs) with 17beta-estradiol (E2) resulted in a rapid, transient, and dose-dependent increase in SphK activity and increased S1P production. Estradiol 71-87 sphingosine kinase 1 Homo sapiens 156-160 26592444-4 2015 The degradative E2, Ube2K, preferentially catalyses formation of Lys48-linked chains, but like most E2s, the molecular basis for chain formation is not well understood. Estradiol 100-103 ubiquitin conjugating enzyme E2 K Homo sapiens 20-25 26287402-10 2015 Phosphorylated AMPK is involved in the regulation of 17beta-estradiol-mediated inhibition of SC viability through increasing p53 and p27 expression and inhibiting mTOR and Skp2 expression. Estradiol 53-69 interferon alpha inducible protein 27 Homo sapiens 133-136 26295370-0 2015 Aging and Loss of Circulating 17beta-Estradiol Alters the Alternative Splicing of ERbeta in the Female Rat Brain. Estradiol 30-46 estrogen receptor 2 Rattus norvegicus 82-88 26408962-12 2015 Accordingly, the medium dose of ZEA-and 17 beta-estradiol significantly up-regulated the expression of cyclin D1 and E2f1 in the testis. Estradiol 48-57 E2F transcription factor 1 Rattus norvegicus 117-121 25463028-4 2015 Here we show that long term estradiol treatment initiated 14 days prior to global ischemia in ovariectomized female rats acts via the IGF-1 receptor to protect the functional integrity of CA1 neurons. Estradiol 28-37 carbonic anhydrase 1 Rattus norvegicus 188-191 25498865-2 2015 We analyzed estradiol-induced modulation of CA1 dendritic spines using adult male ERalphaKO and ERbetaKO mice. Estradiol 12-21 carbonic anhydrase 1 Mus musculus 44-47 25498865-5 2015 Estradiol-induced increase in middle-head spines was observed in ERbetaKO mice (which express ERalpha), but not in ERalphaKO, indicating that ERalpha is necessary for the spinogenesis. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 94-101 25498865-8 2015 As another type of synaptic modulation, we observed that estradiol rapidly enhanced N-methyl-D-aspartate (NMDA)-induced long-term depression (LTD) in CA1 of the wild type mouse hippocampus. Estradiol 57-66 carbonic anhydrase 1 Mus musculus 150-153 26211446-0 2015 17beta-Estradiol up-regulates Nrf2 via PI3K/AKT and estrogen receptor signaling pathways to suppress light-induced degeneration in rat retina. Estradiol 0-16 estrogen receptor 1 Rattus norvegicus 52-69 25649331-11 2015 RESULTS: An LH surge occurred as a result of the oestradiol positive feedback mechanism in group I and in group II, in both EP1 and EP2. Estradiol 49-59 prostaglandin E receptor 1 Homo sapiens 124-127 26052658-4 2015 As determined by Western blotting, 17beta-oestradiol (E2 ) (10(-9) m) increased the nuclear concentration of NF-kappaB/p105, p65 and p50 in GH3 cells. Estradiol 35-52 nucleoporin 107 Rattus norvegicus 119-123 26052658-4 2015 As determined by Western blotting, 17beta-oestradiol (E2 ) (10(-9) m) increased the nuclear concentration of NF-kappaB/p105, p65 and p50 in GH3 cells. Estradiol 54-56 nucleoporin 107 Rattus norvegicus 119-123 26045174-2 2015 On the other hand, estradiol (E2) induces the expression of HSP72, a member of the 70 kDa family of heat shock proteins (HSP70), which are cytoprotective, cardioprotective, and heat inducible. Estradiol 19-28 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 121-126 26045174-2 2015 On the other hand, estradiol (E2) induces the expression of HSP72, a member of the 70 kDa family of heat shock proteins (HSP70), which are cytoprotective, cardioprotective, and heat inducible. Estradiol 30-32 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 121-126 26168035-5 2015 In the present study, we found that 17beta-estradiol (E2) suppresses nuclear factor-kappaB-dependent MMP-1b, MMP-2, MMP-3, MMP-9, MMP-10, and MMP-13 gene activation in microvessel endothelial bEnd.3 cells subjected to oxygen and glucose deprivation/reperfusion injury. Estradiol 36-52 matrix metallopeptidase 3 Mus musculus 116-121 26169831-6 2015 Cyp19a1 encodes aromatase, which transforms testosterone into estradiol. Estradiol 62-71 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 0-7 26289107-4 2015 METHODS: We performed primary culture of EECs and investigated the expression of OPN and MMP-9 in EECs regulated by 17beta-estradiol (E2). Estradiol 116-132 secreted phosphoprotein 1 Homo sapiens 81-84 26282993-4 2015 This study aimed to determine the effect of microRNA-132 (miR-132) on estradiol synthesis in GCs. Estradiol 70-79 microRNA 132 Mus musculus 44-56 26282993-4 2015 This study aimed to determine the effect of microRNA-132 (miR-132) on estradiol synthesis in GCs. Estradiol 70-79 microRNA 132 Mus musculus 58-65 26282993-11 2015 The synthesis of estradiol increased after the overexpression of miR-132 in mouse GCs. Estradiol 17-26 microRNA 132 Mus musculus 65-72 26282993-15 2015 The knockdown of Nurr1 primarily elevated the synthesis of estradiol and partially attenuated the miR-132-induced estradiol elevation, and the ectopic expression of Flag-Nurr1 abrogated the stimulatory effect of miR-132 on estradiol synthesis in mouse GCs. Estradiol 114-123 microRNA 132 Mus musculus 98-105 26269634-2 2015 We found recently that 17beta-estradiol (E2) acutely suppresses GABAergic inhibition in the hippocampus of female rats through a sex-specific estrogen receptor alpha (ERalpha), mGluR, and endocannabinoid-dependent mechanism. Estradiol 23-39 estrogen receptor 1 Rattus norvegicus 167-174 25912736-0 2015 17beta-Estradiol enhances the activation of IFN-alpha signaling in B cells by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p that target IKKepsilon. Estradiol 0-16 inhibitor of kappaB kinase epsilon Mus musculus 161-171 25912736-9 2015 These data suggest that 17beta-estradiol amplifies the activation of IFN-alpha signaling in B cells via IKKepsilon by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Estradiol 24-40 inhibitor of kappaB kinase epsilon Mus musculus 104-114 25993525-4 2015 We therefore investigated the contribution of central PRL/PRLR signaling to the control of estradiol-induced surges of LH and PRL and pulsatile LH secretion under basal and hyperprolactinemic conditions. Estradiol 91-100 prolactin receptor Rattus norvegicus 58-62 25980562-7 2015 Furthermore, in captive Peromyscus, estrogenic compounds (THF-diols) in corncob bedding profoundly alter the rapid effects of estradiol. Estradiol 126-135 thin fur Mus musculus 58-61 26147849-12 2015 The decrease in ERbeta reactivity occurred in a hormonal milieu characterized by a constant concentration of estradiol and decreased plasmatic and tissue DHT. Estradiol 109-118 estrogen receptor 2 Rattus norvegicus 16-22 26171165-9 2015 Concomitant exposure of HOB to 17-beta-estradiol (10 nM) and to specific CB-2 antagonist/inverse agonist (10 microM) showed similar HOB proliferation activity to HOB incubated with 17-beta-estradiol only at a 100 nM concentration. Estradiol 181-198 cannabinoid receptor 2 Homo sapiens 73-77 26171165-10 2015 By contrast, concomitant incubation of HOB with 17-beta-estradiol (10 nM) and specific CB-2 agonist (7.5 microM) resulted in decreased HOB proliferation activity as compared to HOB incubated with 17-beta-estradiol only (10 nM). Estradiol 196-213 cannabinoid receptor 2 Homo sapiens 87-91 26171165-13 2015 In conclusion, for the first time a synergistic interaction between 17-beta-estradiol and specific CB-2 antagonist/inverse agonist was observed in HOB. Estradiol 68-85 cannabinoid receptor 2 Homo sapiens 99-103 25627546-0 2015 Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARalpha Activation. Estradiol 0-9 peroxisome proliferator activated receptor alpha Homo sapiens 113-122 25913303-0 2015 beta-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells. Estradiol 0-14 proprotein convertase subtilisin/kexin type 9 Homo sapiens 28-73 25913303-0 2015 beta-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells. Estradiol 0-14 low density lipoprotein receptor Homo sapiens 96-128 25913303-2 2015 beta-Estradiol upregulates liver low-density lipoprotein receptor (LDLR), which, in turn, decreases circulating levels of low-density lipoprotein, which is a risk factor for coronary artery disease. Estradiol 0-14 low density lipoprotein receptor Homo sapiens 33-65 25913303-2 2015 beta-Estradiol upregulates liver low-density lipoprotein receptor (LDLR), which, in turn, decreases circulating levels of low-density lipoprotein, which is a risk factor for coronary artery disease. Estradiol 0-14 low density lipoprotein receptor Homo sapiens 67-71 25913303-4 2015 Herein, we investigated PCSK9 regulation by beta-estradiol and its impact on LDLR in human hepatocarcinoma HuH7 cells grown in the presence or absence of beta-estradiol. Estradiol 44-58 proprotein convertase subtilisin/kexin type 9 Homo sapiens 24-29 25913303-5 2015 Immunoblot analysis showed upregulation of LDLR at 3 mum beta-estradiol (140%), and the upregulation reached 220% at 10 mum beta-estradiol; only at the latter dose was an increase in LDLR mRNA detected by qPCR, suggesting post-translational regulation of LDLR. Estradiol 57-71 low density lipoprotein receptor Homo sapiens 43-47 25913303-9 2015 Together, these results indicate a requirement for PCSK9 in the beta-estradiol-induced upregulation of LDLR. Estradiol 64-78 proprotein convertase subtilisin/kexin type 9 Homo sapiens 51-56 26003656-5 2015 RESULT(S): We found that the treatment of AMH in GCs for 24/48 h attenuated FSH-induced estradiol production (p < 0.001), had no effect on basal estradiol levels, decreased basal progesterone production (p < 0.001) and FSH-induced StAR expression (p < 0.001). Estradiol 88-97 anti-Mullerian hormone Homo sapiens 42-45 26003656-10 2015 CONCLUSION(S): AMH and BMP-15 by interacting with FSH affect the production of estradiol and progesterone from cultured luteinizing-granulosa cells possibly via Smad5-protein phosphorylation. Estradiol 79-88 anti-Mullerian hormone Homo sapiens 15-18 25701138-2 2015 Here we demonstrate that 17beta-estradiol (E2), strongly inhibits RUNX2-mediated osteoblast-driven osteoclastogenesis in co-cultures. Estradiol 25-41 runt related transcription factor 2 Mus musculus 66-71 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 47-81 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 83-88 25819444-0 2015 The effects of endoxifen and other major metabolites of tamoxifen on the sulfation of estradiol catalyzed by human cytosolic sulfotransferases hSULT1E1 and hSULT1A1*1. Estradiol 86-95 sulfotransferase family 1E member 1 Homo sapiens 143-151 25819444-3 2015 We hypothesized that endoxifen and perhaps other major metabolites of tamoxifen may affect the ability of human estrogen sulfotransferase 1E1 (hSULT1E1) and human phenol sulfotransferase 1A1 isoform 1 (hSULT1A1*1) to catalyze the sulfation of estradiol, an important mechanism in termination of estrogen signaling through loss of activity at estrogen receptors. Estradiol 243-252 sulfotransferase family 1E member 1 Homo sapiens 143-151 25819444-4 2015 Our results indicated that endoxifen, N-desmethyltamoxifen (N-desTAM), 4-hydroxytamoxifen (4-OHTAM), and tamoxifen-N-oxide were weak inhibitors of hSULT1E1 with Ki values ranging from 10 muM to 38 muM (i.e., over 1000 times higher than the 8.1 nM Km value for estradiol as substrate for the enzyme). Estradiol 260-269 sulfotransferase family 1E member 1 Homo sapiens 147-155 25819444-5 2015 In contrast to the results with hSULT1E1, endoxifen and 4-OHTAM were significant inhibitors of the sulfation of 2.0 microM estradiol catalyzed by hSULT1A1*1, with IC50 values (9.9 muM and 1.6 muM, respectively) that were similar to the Km value (1.5 muM) for estradiol as substrate for this enzyme. Estradiol 123-132 sulfotransferase family 1E member 1 Homo sapiens 32-40 25960082-3 2015 Sexual behavior in the female rat is dependent on the activation of ERalpha (estrogen receptor alpha) by estradiol. Estradiol 105-114 estrogen receptor 1 Rattus norvegicus 68-75 26022099-13 2015 17beta-estradiol increased SREBP-1c expression and induced the mature active 60 kDa form of SREBP-1. Estradiol 0-16 sterol regulatory element binding transcription factor 1 Homo sapiens 27-35 26022099-13 2015 17beta-estradiol increased SREBP-1c expression and induced the mature active 60 kDa form of SREBP-1. Estradiol 0-16 sterol regulatory element binding transcription factor 1 Homo sapiens 27-34 25961186-0 2015 High Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element. Estradiol 20-29 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 89-94 25961186-7 2015 CONCLUSION: OS can induce a high maternal E2 environment, which up-regulates HMGCR expression in fetal hepatocytes via an ERE in the promoter, and induces elevated levels of TC and LDL-C in newborns that may be related to increased risk of metabolic disease in adulthood. Estradiol 42-44 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 77-82 25864222-13 2015 However, the influence of 17 beta-estradiol was lost in cirrhotic females, which may be attributed, at least partly, to intrahepatic ER alpha down-regulation in females with cirrhosis. Estradiol 26-43 estrogen receptor 1 Rattus norvegicus 133-141 23700305-0 2015 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression. Estradiol 46-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-143 25844889-6 2015 RESULTS: Uptake studies showed a higher accumulation in the presence of inhibitors (GF120918 and ketoconazole for P-gp; MK571 for MRP2; and beta-estradiol for BCRP) as well as RX-10045. Estradiol 140-154 ATP binding cassette subfamily G member 2 Canis lupus familiaris 159-163 25130479-2 2015 Reverse transcription polymerase chain reaction (RT-PCR) studies showed that 10 nM estradiol enhanced MLL transcription in addition to its common translocation partners, MLLT2 (AF4) and MLLT3 (AF9). Estradiol 83-92 lysine methyltransferase 2A Homo sapiens 102-105 25928008-0 2015 Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. Estradiol 0-9 HOX transcript antisense RNA Homo sapiens 18-24 25928008-0 2015 Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. Estradiol 0-9 microRNA 148a Homo sapiens 50-58 25530540-0 2015 A competitive photoelectrochemical assay for estradiol based on in situ generated CdS-enhanced TiO2. Estradiol 45-54 CDP-diacylglycerol synthase 1 Homo sapiens 82-85 25530540-1 2015 A novel and simple photoelectrochemical (PEC) bioassay protocol for estradiol was proposed based on in situ generated CdS-enhanced TiO2 film via competitive strategy. Estradiol 68-77 CDP-diacylglycerol synthase 1 Homo sapiens 118-121 25582913-2 2015 A major mechanism responsible for seasonal reproduction is a striking increase in the responsiveness of gonadotropin-releasing hormone (GnRH) neurons to the negative feedback effects of estradiol. Estradiol 186-195 Progonadoliberin-1 Ovis aries 104-134 25582913-2 2015 A major mechanism responsible for seasonal reproduction is a striking increase in the responsiveness of gonadotropin-releasing hormone (GnRH) neurons to the negative feedback effects of estradiol. Estradiol 186-195 Progonadoliberin-1 Ovis aries 136-140 25392126-6 2015 Increases in estrone, estradiol, free and bioavailable estradiol, testosterone, usCRP and 2OHE levels were observed in LP-L compared with FP (p < 0.01), with a borderline elevation in IFG-I levels (p = 0.06). Estradiol 22-31 lipoprotein lipase Homo sapiens 119-123 25392126-6 2015 Increases in estrone, estradiol, free and bioavailable estradiol, testosterone, usCRP and 2OHE levels were observed in LP-L compared with FP (p < 0.01), with a borderline elevation in IFG-I levels (p = 0.06). Estradiol 55-64 lipoprotein lipase Homo sapiens 119-123 25662808-10 2015 In ovariectomized mice, estradiol treatment increased uterine expression of mature BDNF greater than 6-fold (P = 0.013, 25 kDa; P = 0.003, 27 kDa), pro-BDNF 5-fold (P = 0.041, 37 kDa band; P = 0.046, 40 kDa band), and NGFR 5-fold (P < 0.001) when compared with other treatments. Estradiol 24-33 brain derived neurotrophic factor Mus musculus 83-87 25662808-10 2015 In ovariectomized mice, estradiol treatment increased uterine expression of mature BDNF greater than 6-fold (P = 0.013, 25 kDa; P = 0.003, 27 kDa), pro-BDNF 5-fold (P = 0.041, 37 kDa band; P = 0.046, 40 kDa band), and NGFR 5-fold (P < 0.001) when compared with other treatments. Estradiol 24-33 brain derived neurotrophic factor Mus musculus 152-156 25662808-15 2015 WIDER IMPLICATIONS OF THE FINDINGS: Results of this study demonstrate the uterine regulation of BDNF and NGFR by estradiol, and highlight the striking difference between hormone exposure during the estrous cycle and daily estradiol exposure after ovariectomy on neurotrophin expression in the uterus. Estradiol 113-122 brain derived neurotrophic factor Mus musculus 96-100 25739982-6 2015 U0126 (5 muM), a specific inhibitor of (MEK1/2), and 10-DEBC (2 muM), a selective inhibitor of AKT, both significantly reduced 17beta-estradiol-induced phosphorylation of mTOR. Estradiol 127-143 mitogen-activated protein kinase kinase 1 Homo sapiens 40-46 25739982-7 2015 Rapamycin suppressed 17beta-estradiol-induced Sertoli cell proliferation, appearing to act by reducing the abundance of SKP2, CCND1, and CCNE1 mRNA as well as RB and EMI1 protein. Estradiol 21-37 F-box protein 5 Homo sapiens 166-170 25892958-6 2015 Knockout of Kdm3b in female mice caused irregular estrous cycles, decreased 45% of the ovulation capability and 47% of the fertilization rate, and reduced 44% of the uterine decidual response, which were accompanied with a more than 50% decrease in the circulating levels of the 17beta-estradiol. Estradiol 279-295 KDM3B lysine (K)-specific demethylase 3B Mus musculus 12-17 25733860-0 2015 Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17beta is mediated by a PKC-ERK1/2-mTOR signaling pathway. Estradiol 69-85 mechanistic target of rapamycin kinase Mus musculus 114-118 25545386-2 2015 It has been proposed that estradiol (E2) activation of ERalpha in kisspeptin neurons in the arcuate nucleus (ARC) suppresses GnRH/LH secretion (negative feedback), whereas E2 activation of ERalpha in kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) mediates the release of preovulatory GnRH/LH surges (positive feedback). Estradiol 26-35 estrogen receptor 1 (alpha) Mus musculus 55-62 25577757-0 2015 Potentiation of 17beta-estradiol on neuroexcitability by HCN-mediated neuromodulation of fast-afterhyperpolarization and late-afterdepolarization in low-threshold and sex-specific myelinated Ah-type baroreceptor neurons via GPR30 in female rats. Estradiol 16-32 cyclic nucleotide gated channel subunit alpha 1 Rattus norvegicus 57-60 25577757-0 2015 Potentiation of 17beta-estradiol on neuroexcitability by HCN-mediated neuromodulation of fast-afterhyperpolarization and late-afterdepolarization in low-threshold and sex-specific myelinated Ah-type baroreceptor neurons via GPR30 in female rats. Estradiol 16-32 G protein-coupled estrogen receptor 1 Rattus norvegicus 224-229 25283641-3 2015 In a reducing environment estradiol competed for binding to the 1,25D3-MARRS receptor/PDIA3/ERp57. Estradiol 26-35 protein disulfide isomerase associated 3 Mus musculus 86-91 25283641-3 2015 In a reducing environment estradiol competed for binding to the 1,25D3-MARRS receptor/PDIA3/ERp57. Estradiol 26-35 protein disulfide isomerase associated 3 Mus musculus 92-97 26312915-9 2015 Serum oestradiol concentrations were also significantly reduced in the NKB antagonist group (mean 112 7 pmol/L [SD 56 0] vs 240 1 [73 6], p=0 005): in keeping with this finding endometrial thickness was also reduced (mean 3 5 mm [SD 0 5] vs 6 4 [3 2], p=0 05). Estradiol 6-16 tachykinin precursor 3 Homo sapiens 71-74 26312915-12 2015 INTERPRETATION: We have shown for the first time, to our knowledge, that NKB antagonist is a potent suppressor of follicle development and oestradiol secretion in women. Estradiol 139-149 tachykinin precursor 3 Homo sapiens 73-76 25592968-0 2015 17beta-estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner. Estradiol 6-16 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 148-155 25394658-0 2015 Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-alpha in female mice liver. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 91-114 25395681-8 2015 Taken together, this study suggests a potential involvement of ADM2 in the rat ovary in regulating synthesis of estradiol to support ovulation and facilitate efficient implantation and placental development for a successful pregnancy. Estradiol 112-121 adrenomedullin 2 Rattus norvegicus 63-67 25167991-12 2015 Cotreatment with the estrogen receptor-alpha antagonist raloxifene resulted in decreased bladder mass compared to that in wild-type mice treated with testosterone plus 17beta-estradiol. Estradiol 168-184 estrogen receptor 1 (alpha) Mus musculus 21-44 25523052-0 2015 17beta-Estradiol attenuates hematoma expansion through estrogen receptor alpha/silent information regulator 1/nuclear factor-kappa b pathway in hyperglycemic intracerebral hemorrhage mice. Estradiol 0-16 sirtuin 1 Mus musculus 79-109 25367280-11 2015 A significant positive correlation (p < 0.05) between PRL and progesterone and between PRL and estradiol levels was found in this study. Estradiol 98-107 prolactin Capra hircus 90-93 25453773-5 2015 Local estradiol signaling enhances the auditory-evoked firing rate of neurons in NCM to a variety of stimuli, while also enhancing the selectivity of auditory-evoked responses of neurons in a downstream sensorimotor brain region, HVC (proper name). Estradiol 6-15 CWC22 spliceosome associated protein homolog Homo sapiens 81-84 25399436-6 2015 Pharmacological studies indicated that these effects were attributable to upregulation of CYP1a1 and subsequent increased metabolism of estradiol to a downstream intermediate 2-methoxyestradiol. Estradiol 136-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 90-96 25399436-8 2015 Our novel results on estradiol metabolism in fetal and early postnatal lung in the context of hyperoxia indicate CYP1a1 as a potential mechanism for the protective effect of estradiol in hyperoxia-exposed immature lung, which may help explain the sex difference in neonatal lung diseases. Estradiol 21-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 25550540-8 2015 Estradiol (E2) or dexamethasone (Dexa) significantly modulated IGF-1Ea and IGF-1Eb and down-regulated the Ec peptide in PC3. Estradiol 11-13 proprotein convertase subtilisin/kexin type 1 Homo sapiens 120-123 25411391-5 2015 Addition of FGF18 decreased abundance of mRNA encoding the antiapoptotic proteins GADD45B and MDM2, and increased that encoding the proapoptotic protein BBC3; these effects were reversed by coculture with estradiol. Estradiol 205-214 bcl-2-binding component 3 Bos taurus 153-157 25701261-6 2015 Interestingly, molecular analysis revealed that estradiol treatment markedly increases expression of cyclin A and B, and decreases p21 and p27 in the insulin-primed cells. Estradiol 48-57 H3 histone pseudogene 16 Homo sapiens 131-134 25701261-6 2015 Interestingly, molecular analysis revealed that estradiol treatment markedly increases expression of cyclin A and B, and decreases p21 and p27 in the insulin-primed cells. Estradiol 48-57 interferon alpha inducible protein 27 Homo sapiens 139-142 26230882-3 2015 Inhibiting 17-beta HSD2 can help in increasing estradiol concentration. Estradiol 47-56 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 19-23 25646042-9 2015 Significant positive correlation between PSA and 17beta-estradiol was observed in prostate disorders (BPH and CaP patients: r = 0.347; p = 0.000). Estradiol 49-65 kallikrein related peptidase 3 Homo sapiens 41-44 26491436-9 2015 In conclusion, the loss of estradiol increases renal damage while the treatment with estradiol benefits renal function by modulating arachidonic acid metabolism through the 5-lipoxygenase and cytochrome p450 4A pathways. Estradiol 85-94 arachidonate 5-lipoxygenase Rattus norvegicus 173-187 25864740-0 2015 Association between progesterone and estradiol-17beta treatment and protein expression of pgr and PGRMC1 in porcine luminal epithelial cells: a real-time cell proliferation approach. Estradiol 37-46 progesterone receptor membrane component 1 Homo sapiens 98-104 25864740-9 2015 Confocal microscopic observations revealed that higher concentrations of E2 upregulate the expression of both PGR and PGRMC1. Estradiol 73-75 progesterone receptor membrane component 1 Homo sapiens 118-124 26004302-7 2015 In addition, kisspeptin or GnRH injection overrode estradiol-dependent prepubertal LH suppression, suggesting that estrogen inhibits the kisspeptin-GnRH cascade during the prepubertal period. Estradiol 51-60 gonadotropin releasing hormone 1 Rattus norvegicus 27-31 26004302-7 2015 In addition, kisspeptin or GnRH injection overrode estradiol-dependent prepubertal LH suppression, suggesting that estrogen inhibits the kisspeptin-GnRH cascade during the prepubertal period. Estradiol 51-60 gonadotropin releasing hormone 1 Rattus norvegicus 148-152 25338647-7 2015 Analysis of the involvement of the EGFR support previous findings that designate this receptor as a mediator of the non-genomic effects of estradiol; blocking EGFR also reverses the inhibitory effect of tamoxifen. Estradiol 139-148 epidermal growth factor receptor Mus musculus 35-39 25807798-0 2015 [Effects of 17beta-estradiol on the expression Caveolin-1 and type III collagen in the mouse lung fibroblast stimulated by SiO2]. Estradiol 12-28 caveolin 1, caveolae protein Mus musculus 47-57 25551628-0 2014 17beta-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro. Estradiol 0-16 serum/glucocorticoid regulated kinase 1 Mus musculus 90-94 25551628-3 2014 This study is conducted to assess the role of ENaC and the PI3K/Akt/SGK1 signaling pathway in 17beta-estradiol therapy in attenuating LPS-induced ALI. Estradiol 94-110 serum/glucocorticoid regulated kinase 1 Mus musculus 68-72 25551628-11 2014 17beta-estradiol promoted the expression and surface abundance of alpha-ENaC, and increased the levels of phosphorylated-Akt and phosphorylated-SGK1 following LPS challenge. Estradiol 0-16 sodium channel, nonvoltage-gated 1 alpha Mus musculus 66-76 25551628-11 2014 17beta-estradiol promoted the expression and surface abundance of alpha-ENaC, and increased the levels of phosphorylated-Akt and phosphorylated-SGK1 following LPS challenge. Estradiol 0-16 serum/glucocorticoid regulated kinase 1 Mus musculus 144-148 25551628-13 2014 CONCLUSION: 17beta-estradiol attenuates LPS-induced ALI not only by repressing inflammation, but also by reducing pulmonary edema via elevation of alpha-ENaC expression and membrane abundance. Estradiol 12-28 sodium channel, nonvoltage-gated 1 alpha Mus musculus 147-157 25205451-6 2014 However, after the CBM peptide or estradiol was injected into the OVX mice for 2 months, the increased serum OCN concentration and alkaline phosphate (ALP) activity were decreased in the estradiol-treated group (OVX-E) and the high-concentration CBM peptide-treated group (OVX-HP). Estradiol 34-43 bone gamma-carboxyglutamate protein 2 Mus musculus 109-112 25205451-6 2014 However, after the CBM peptide or estradiol was injected into the OVX mice for 2 months, the increased serum OCN concentration and alkaline phosphate (ALP) activity were decreased in the estradiol-treated group (OVX-E) and the high-concentration CBM peptide-treated group (OVX-HP). Estradiol 187-196 bone gamma-carboxyglutamate protein 2 Mus musculus 109-112 25674214-1 2014 OBJECTIVE: To detect the effects of 17beta-estradiol (E2) on the expression of calbindin-D9k (CaBP-9k) in pituitary GH3 cells, and to determine the antagonistic effect of a selective estrogen receptor (ER) antagonist (ICI 182 780) on CaBP-9k expression. Estradiol 36-52 S100 calcium binding protein G Rattus norvegicus 79-92 25256868-0 2014 Both GPER and membrane oestrogen receptor-alpha activation protect ventricular remodelling in 17beta oestradiol-treated ovariectomized infarcted rats. Estradiol 94-111 G protein-coupled estrogen receptor 1 Rattus norvegicus 5-47 25256868-2 2014 We investigated whether the attenuated hypertrophic effect of oestradiol was via activation of phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) through non-genomic action. Estradiol 62-72 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Rattus norvegicus 95-124 25256868-5 2014 The phosphorylation of Akt and eNOS was significantly decreased in infarcted rats and restored by oestradiol and G-1, implying the GPER pathway in this process. Estradiol 98-108 G protein-coupled estrogen receptor 1 Rattus norvegicus 131-135 25256868-6 2014 Oestradiol-induced Akt phosphorylation was not abrogated by G-15 (a GPER blocker). Estradiol 0-10 G protein-coupled estrogen receptor 1 Rattus norvegicus 68-72 25138705-7 2014 In ovariectomised mice, exogenous oestradiol administration increased mammary gland CSF1, CSF2, IFNG and LIF, compared with ovariectomised control mice. Estradiol 34-44 leukemia inhibitory factor Mus musculus 105-108 25280432-4 2014 Intramuscular injection of the GPR30 agonists raloxifene or 17beta-estradiol produced a fast-onset, persistent, mechanical hyperalgesia at the site of the injection. Estradiol 60-76 G protein-coupled estrogen receptor 1 Rattus norvegicus 31-36 25280432-6 2014 Pretreatment with the GPR30 antagonist G-36 also inhibited the hyperalgesia induced by raloxifene or 17beta-estradiol in naive control rats. Estradiol 101-117 G protein-coupled estrogen receptor 1 Rattus norvegicus 22-27 25469035-10 2014 Our results showed that treatment with 17beta-estradiol and/or ER agonists in human LoVo colorectal cancer cells activated p53 and then up-regulated p21 and p27 protein levels, subsequently inhibiting the downstream target gene, cyclin D1, which regulates cell proliferation. Estradiol 39-55 H3 histone pseudogene 16 Homo sapiens 149-152 25469035-10 2014 Our results showed that treatment with 17beta-estradiol and/or ER agonists in human LoVo colorectal cancer cells activated p53 and then up-regulated p21 and p27 protein levels, subsequently inhibiting the downstream target gene, cyclin D1, which regulates cell proliferation. Estradiol 39-55 interferon alpha inducible protein 27 Homo sapiens 157-160 25394221-2 2014 Previous studies have shown that 17beta-estradiol activates the HIF-1alpha signaling pathway and that mice with conditional activation of the HIF-1alpha signaling pathway in osteoblasts are protected from ovariectomy (OVX)-induced bone loss. Estradiol 33-49 hypoxia inducible factor 1, alpha subunit Mus musculus 64-74 25242645-0 2014 Effects of 17beta-estradiol on the cytoarchitecture of pyramidal CA1 neurons in normoglycemic and diabetic male spontaneously hypertensive rats. Estradiol 11-27 carbonic anhydrase 1 Rattus norvegicus 65-68 25242645-12 2014 Thus, changes of cytoarchitecture of CA1 neurons due to 17beta-estradiol treatment of normoglycemic SHR persisted after diabetes induction. Estradiol 56-72 carbonic anhydrase 1 Rattus norvegicus 37-40 25030371-1 2014 UNLABELLED: The role of 17beta-estradiol (E2) in breast cancer development and tumor growth has traditionally been attributed exclusively to the activation of estrogen receptor-alpha (ERalpha). Estradiol 24-40 estrogen receptor 1 (alpha) Mus musculus 159-182 25030371-1 2014 UNLABELLED: The role of 17beta-estradiol (E2) in breast cancer development and tumor growth has traditionally been attributed exclusively to the activation of estrogen receptor-alpha (ERalpha). Estradiol 24-40 estrogen receptor 1 (alpha) Mus musculus 184-191 25209411-8 2014 Therefore, OTR(-/-) mice injected with 17beta-estradiol do not show any effects on bone formation parameters, while the same treatment increases bone mass in wild-type mice. Estradiol 39-55 oxytocin receptor Mus musculus 11-14 25117411-7 2014 The effects of estradiol on fat mass and B lymphopoiesis required ERalpha specifically in NHC and HC, respectively. Estradiol 15-24 estrogen receptor 1 (alpha) Mus musculus 66-73 25086228-7 2014 17beta-Estradiol but not genistein reduced the negative impact of aging on central insulin sensitivity by favoring this GLUT4 translocation, and therefore could be neuroprotective against the associated neurodegenerative diseases. Estradiol 0-16 solute carrier family 2 member 4 Rattus norvegicus 120-125 25151950-3 2014 The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Estradiol 116-125 vascular endothelial growth factor A Rattus norvegicus 4-8 25151950-3 2014 The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Estradiol 116-125 vascular endothelial growth factor A Rattus norvegicus 25-29 24510074-2 2014 Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 78-101 24510074-2 2014 Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 103-110 24510074-2 2014 Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 78-95 24510074-2 2014 Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling. Estradiol 270-279 estrogen receptor 1 (alpha) Mus musculus 78-101 24510074-2 2014 Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling. Estradiol 270-279 estrogen receptor 1 (alpha) Mus musculus 103-110 24510074-2 2014 Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling. Estradiol 270-279 estrogen receptor 1 (alpha) Mus musculus 78-95 24510074-4 2014 Research employing receptor knockout mice demonstrate that ERalpha maintains transcription and memory as estradiol levels decline. Estradiol 105-114 estrogen receptor 1 (alpha) Mus musculus 59-66 24510074-7 2014 Vector-mediated expression of estrogen receptors in the hippocampus provides an innovative research approach and suggests that memory depends on the relative expression of ERalpha and ERbeta interacting with estradiol levels. Estradiol 208-217 estrogen receptor 1 (alpha) Mus musculus 172-179 25088042-9 2014 A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17beta-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. Estradiol 132-148 solute carrier organic anion transporter family, member 1D1 Danio rerio 23-30 25087654-2 2014 However, little is known about the effects of estradiol and progesterone (P) on estrogen receptor alpha (ERalpha) expression in this nucleus. Estradiol 46-55 estrogen receptor 1 Rattus norvegicus 105-112 25257533-5 2014 More specifically, ERalpha represses the expression of the CYP1A1 gene, which encodes an enzyme that converts 17beta-estradiol into 2-hydroxyestradiol. Estradiol 110-126 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-65 24862866-1 2014 AIM: The purpose of this study was to determine whether 17beta-estradiol (E2) enhances the activation, proliferation and differentiation of muscle satellite cells (SC) following eccentric exercise either via insulin-like growth factor-1 (IGF-1) or through phosphatidylinositol 3-kinase (PI3K) signalling. Estradiol 56-72 insulin-like growth factor 1 Rattus norvegicus 208-236 24862866-1 2014 AIM: The purpose of this study was to determine whether 17beta-estradiol (E2) enhances the activation, proliferation and differentiation of muscle satellite cells (SC) following eccentric exercise either via insulin-like growth factor-1 (IGF-1) or through phosphatidylinositol 3-kinase (PI3K) signalling. Estradiol 56-72 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Rattus norvegicus 256-285 25156241-4 2014 This study was aimed at determining the impact of Nar on the estrogen receptor (ERalpha and beta)-dependent signals important for 17beta-estradiol (E2) effect in muscle cells (rat L6 myoblasts, mouse C2C12 myoblasts, and mouse skeletal muscle satellite cells). Estradiol 130-146 estrogen receptor 1 Rattus norvegicus 61-78 25156241-4 2014 This study was aimed at determining the impact of Nar on the estrogen receptor (ERalpha and beta)-dependent signals important for 17beta-estradiol (E2) effect in muscle cells (rat L6 myoblasts, mouse C2C12 myoblasts, and mouse skeletal muscle satellite cells). Estradiol 130-146 estrogen receptor 1 Rattus norvegicus 80-96 24974217-11 2014 beta-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERalpha-neutralizing antibody or ERK1/2 inhibitor. Estradiol 0-14 estrogen receptor 1 (alpha) Mus musculus 95-102 24983467-7 2014 In saliva, estradiol concentrations associated positively with TIMP-1 and negatively with MPO and MMP-8 concentrations. Estradiol 11-20 matrix metallopeptidase 8 Homo sapiens 98-103 24983467-9 2014 Throughout gestation, estradiol modulates the inflammatory response by inhibiting neutrophilic enzymes, such as MMP-8. Estradiol 22-31 matrix metallopeptidase 8 Homo sapiens 112-117 25128537-0 2014 17beta-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice. Estradiol 0-16 brain derived neurotrophic factor Mus musculus 98-102 24608267-5 2014 Synaptic plasticity was also regulated by endogenous estradiol, which favored synaptic potentiation in a GluN2B-dependent manner. Estradiol 53-62 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 105-111 24944021-0 2014 Estradiol determines the effects of PTH on ERalpha-dependent transcription in MC3T3-E1 cells. Estradiol 0-9 estrogen receptor 1 (alpha) Mus musculus 43-50 24845419-8 2014 Estradiol (E2) inhibited miR-21 expression via ERalpha. Estradiol 0-9 microRNA 21 Homo sapiens 25-31 24807244-1 2014 PROBLEM: Estradiol can directly affect epithelial cells or indirectly affect epithelial cells via stromal fibroblast secretion of growth factors, such as keratinocyte growth factor (KGF). Estradiol 9-18 fibroblast growth factor 7 Mus musculus 154-180 24807244-1 2014 PROBLEM: Estradiol can directly affect epithelial cells or indirectly affect epithelial cells via stromal fibroblast secretion of growth factors, such as keratinocyte growth factor (KGF). Estradiol 9-18 fibroblast growth factor 7 Mus musculus 182-185 24807244-5 2014 RESULTS: Estradiol inhibited CCL20 secretion by freshly isolated and polarized uterine epithelial cells in the presence or absence of KGF. Estradiol 9-18 chemokine (C-C motif) ligand 20 Mus musculus 29-34 24807244-9 2014 The inhibitory effect of estradiol on CCL20 secretion was reversed with ICI 182,780, an estrogen receptor antagonist, indicating that this effect is estrogen receptor mediated. Estradiol 25-34 chemokine (C-C motif) ligand 20 Mus musculus 38-43 24807244-10 2014 CONCLUSIONS: Our data indicate that estradiol is important in regulating the effects of KGF on mouse uterine epithelial cell secretion of CCL20 and CXCL1. Estradiol 36-45 fibroblast growth factor 7 Mus musculus 88-91 24807244-10 2014 CONCLUSIONS: Our data indicate that estradiol is important in regulating the effects of KGF on mouse uterine epithelial cell secretion of CCL20 and CXCL1. Estradiol 36-45 chemokine (C-C motif) ligand 20 Mus musculus 138-143 24823389-3 2014 In this study, we have tested novel compounds lacking the B ring of 17-hydroxy-beta-estradiol (E2) (A-CD compounds) with differing ratios of ERalpha:ERbeta binding affinities for the ability to reduce diurnal/nocturnal tail-skin temperatures (TSTs) in the ovariectomized female rat menopausal hot flash model. Estradiol 95-97 estrogen receptor 1 Rattus norvegicus 141-148 24823389-3 2014 In this study, we have tested novel compounds lacking the B ring of 17-hydroxy-beta-estradiol (E2) (A-CD compounds) with differing ratios of ERalpha:ERbeta binding affinities for the ability to reduce diurnal/nocturnal tail-skin temperatures (TSTs) in the ovariectomized female rat menopausal hot flash model. Estradiol 95-97 estrogen receptor 2 Rattus norvegicus 149-155 24975515-4 2014 Here we demonstrate that 17beta-estradiol, tamoxifen, and fulvestrant induce nuclear and nucleolar translocation of HE4 and that HE4 overexpression induces resistance to antiestrogens. Estradiol 25-41 WAP four-disulfide core domain 2 Homo sapiens 116-119 24828505-5 2014 Overexpression of miR-320 inhibited estradiol synthesis and proliferation of GCs through targeting E2F1 and SF-1. Estradiol 36-45 microRNA 320 Mus musculus 18-25 24828505-5 2014 Overexpression of miR-320 inhibited estradiol synthesis and proliferation of GCs through targeting E2F1 and SF-1. Estradiol 36-45 E2F transcription factor 1 Mus musculus 99-103 24828505-9 2014 Injection of miR-320 into the ovaries of mice partially promoted the production of testosterone and progesterone but inhibited estradiol release in vivo. Estradiol 127-136 microRNA 320 Mus musculus 13-20 23912458-4 2014 Both RBCK1 and FKBPL are upregulated by 17-beta-estradiol and interact within heat shock protein 90 chaperone complexes, together with estrogen receptor-alpha (ERalpha). Estradiol 40-57 FKBP prolyl isomerase like Homo sapiens 15-20 24682418-8 2014 CONCLUSION: This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression. Estradiol 66-75 hydroxysteroid 17-beta dehydrogenase 2 Homo sapiens 133-140 24706985-5 2014 The aim of the present study was to evaluate the relative contributions of estrogen receptor alpha (ERalpha), ERbeta, and G protein-coupled estrogen receptor 1 (GPER) to the enhanced signaling of the inflammatory mediator BK by 17beta-estradiol (17beta-E2) in primary sensory neurons from female rats in culture (ex vivo) and in behavioral assays of nociception in vivo. Estradiol 228-244 G protein-coupled estrogen receptor 1 Rattus norvegicus 122-159 24706985-5 2014 The aim of the present study was to evaluate the relative contributions of estrogen receptor alpha (ERalpha), ERbeta, and G protein-coupled estrogen receptor 1 (GPER) to the enhanced signaling of the inflammatory mediator BK by 17beta-estradiol (17beta-E2) in primary sensory neurons from female rats in culture (ex vivo) and in behavioral assays of nociception in vivo. Estradiol 228-244 G protein-coupled estrogen receptor 1 Rattus norvegicus 161-165 24706985-6 2014 The effects of 17beta-E2 on BK responses were mimicked by ERalpha-selective agonists and blocked by ERalpha-selective antagonists and by small interfering RNA knockdown of ERalpha. Estradiol 21-24 estrogen receptor 1 Rattus norvegicus 58-65 24706985-6 2014 The effects of 17beta-E2 on BK responses were mimicked by ERalpha-selective agonists and blocked by ERalpha-selective antagonists and by small interfering RNA knockdown of ERalpha. Estradiol 21-24 estrogen receptor 1 Rattus norvegicus 100-107 24706985-6 2014 The effects of 17beta-E2 on BK responses were mimicked by ERalpha-selective agonists and blocked by ERalpha-selective antagonists and by small interfering RNA knockdown of ERalpha. Estradiol 21-24 estrogen receptor 1 Rattus norvegicus 100-107 24671882-7 2014 In cultured bovine granulosa cells, human recombinant CHEMERIN (hRec, 200 ng/ml) reduced production of both progesterone and estradiol, cholesterol content, STAR abundance, CYP19A1 and HMGCR proteins, and the phosphorylation levels of MAPK3/MAPK1 in the presence or absence of FSH (10(-8) M) and IGF1 (10(-8) M). Estradiol 125-134 RBPJ pseudogene 4 Homo sapiens 64-68 24576292-7 2014 AMH was inversely correlated to total dosage of gonadotropins and age, AMH positively had a significant correlation with maximum estradiol levels, duration of stimulations and total number of oocytes retrieved. Estradiol 129-138 anti-Mullerian hormone Homo sapiens 71-74 24676858-3 2014 Estradiol induction of HSFA4A in transgenic plants decreases, while the knockout hsfa4a mutation elevates hydrogen peroxide accumulation and lipid peroxidation. Estradiol 0-9 heat shock transcription factor A4A Arabidopsis thaliana 23-29 24736568-11 2014 E2-dependent activation of GPER-1 lowers testosterone production in isolated rats LCs and in human testis, with statistically and clinically significant drops in testosterone production by 20-30% as compared to estradiol-naive LC. Estradiol 211-220 G protein-coupled estrogen receptor 1 Rattus norvegicus 27-33 24445074-6 2014 Collectively, the results indicated that short-term treatment of ovariectomized rats with a GPR30 agonist was sufficient to enhance spatial recognition memory, an effect that also occurred following short-term treatment with a low dose of estradiol. Estradiol 239-248 G protein-coupled estrogen receptor 1 Rattus norvegicus 92-97 24515104-0 2014 Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3). Estradiol 0-9 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 70-76 24659985-9 2014 In vitro, HO-1 protein levels in AN3 cells augmented after the addition of physiological concentrations of progesterone and estradiol, which confirmed our in vivo observations. Estradiol 124-133 heme oxygenase 1 Homo sapiens 10-14 24252383-1 2014 The steroid 17beta-estradiol (E2) modulates energy homeostasis by reducing feeding behavior and increasing energy expenditure primarily through estrogen receptor alpha (ERalpha)-mediated mechanisms. Estradiol 12-28 estrogen receptor 1 (alpha) Mus musculus 144-167 24252383-1 2014 The steroid 17beta-estradiol (E2) modulates energy homeostasis by reducing feeding behavior and increasing energy expenditure primarily through estrogen receptor alpha (ERalpha)-mediated mechanisms. Estradiol 12-28 estrogen receptor 1 (alpha) Mus musculus 169-176 24252383-1 2014 The steroid 17beta-estradiol (E2) modulates energy homeostasis by reducing feeding behavior and increasing energy expenditure primarily through estrogen receptor alpha (ERalpha)-mediated mechanisms. Estradiol 30-32 estrogen receptor 1 (alpha) Mus musculus 144-167 24252383-1 2014 The steroid 17beta-estradiol (E2) modulates energy homeostasis by reducing feeding behavior and increasing energy expenditure primarily through estrogen receptor alpha (ERalpha)-mediated mechanisms. Estradiol 30-32 estrogen receptor 1 (alpha) Mus musculus 169-176 24269736-3 2014 This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid. Estradiol 53-55 neuropeptide Y Homo sapiens 73-76 24269737-6 2014 Numbers of estrogen receptor-beta positive cells were significantly higher after estradiol treatment; an effect that was not altered by pretreatment of cultures with tamoxifen. Estradiol 81-90 estrogen receptor 2 Rattus norvegicus 11-33 24440569-2 2014 We demonstrate here that both 17-beta-estradiol (E2) and ICI enhance cell adhesion to matrigel in MCF-7 breast cancer cells, with increased autolysis of calpain 1 (large subunit) and proteolysis of focal adhesion kinase (FAK), indicating calpain activation. Estradiol 30-47 calpain 1 Homo sapiens 153-162 24440569-2 2014 We demonstrate here that both 17-beta-estradiol (E2) and ICI enhance cell adhesion to matrigel in MCF-7 breast cancer cells, with increased autolysis of calpain 1 (large subunit) and proteolysis of focal adhesion kinase (FAK), indicating calpain activation. Estradiol 30-47 calpain 1 Homo sapiens 153-160 24361177-3 2014 The increased aromatization of testosterone in male mice during early development and the link between 17-beta-estradiol (E2) levels and BDNF transcription substantiate this hypothesis. Estradiol 103-120 brain derived neurotrophic factor Mus musculus 137-141 24611062-5 2014 Estradiol-induced mTOR phosphorylation was preceded by rapid and transient activation of both extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) and by phosphatase and tensin homolog (PTEN) degradation. Estradiol 0-9 phosphatase and tensin homolog Homo sapiens 204-208 24551115-14 2014 In ovariectomized female rats, estradiol replacement exerts potent immunomodulatory effects including attenuation of microglia sensitization, initiation of M2-like activation and modulation of complement expression by targeting hippocampal neurons and glial cells through ERalpha and ERbeta. Estradiol 31-40 estrogen receptor 1 Rattus norvegicus 272-279 24551115-14 2014 In ovariectomized female rats, estradiol replacement exerts potent immunomodulatory effects including attenuation of microglia sensitization, initiation of M2-like activation and modulation of complement expression by targeting hippocampal neurons and glial cells through ERalpha and ERbeta. Estradiol 31-40 estrogen receptor 2 Rattus norvegicus 284-290 24246781-6 2014 High values of CLR increased removal of estradiol and carbamazepine but lowered that of testosterone and atrazine. Estradiol 40-49 doublecortin like kinase 3 Homo sapiens 15-18 24121025-0 2014 Ovariectomy and 17beta-estradiol replacement play a role on the expression of Endonuclease-G and phosphorylated cyclic AMP response element-binding (CREB) protein in hippocampus. Estradiol 16-32 cAMP responsive element binding protein 1 Rattus norvegicus 149-153 24371309-1 2014 Estrogen receptor alpha (ERalpha) activation functions AF-1 and AF-2 classically mediate gene transcription in response to estradiol (E2). Estradiol 123-132 estrogen receptor 1 (alpha) Mus musculus 0-23 24371309-1 2014 Estrogen receptor alpha (ERalpha) activation functions AF-1 and AF-2 classically mediate gene transcription in response to estradiol (E2). Estradiol 123-132 estrogen receptor 1 (alpha) Mus musculus 25-32 24528081-2 2014 17beta-estradiol (E2), the main steroidal estrogen present in women, is metabolized via two major pathways: formation of the 2-hydroxyestradiol (2-OH E2) and 4-hydroxyestradiol (4-OH E2) through the action of Cytochrome P450 (CYP) 1A1 and 1B1, respectively. Estradiol 0-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 209-242 24104551-2 2014 Human clinical trials showed that estrogen [17beta-estradiol (E2)], the ligand of nuclear receptors estrogen receptor alpha (ERalpha) and ERbeta, inhibited colorectal cancer (CRC) in women. Estradiol 44-60 estrogen receptor 1 (alpha) Mus musculus 100-123 23754308-10 2014 Oestradiol supplementation in ovariectomized females increased NK1r internalization to levels observed in intact females. Estradiol 0-10 tachykinin receptor 1 Rattus norvegicus 63-67 25403075-6 2014 Additions of FSH, IGF-I and ghrelin to culture medium reduced the release of progesterone and increased testosterone and estradiol output by fragments isolated from control animals. Estradiol 121-130 insulin-like growth factor I Oryctolagus cuniculus 18-23 24166993-3 2014 Treatment of feedlot steers with a combined estradiol (E2) and trenbolone acetate (TBA) implant results in an increased number of muscle satellite cells, increased expression of IGF-1 mRNA in muscle tissue, and increased levels of circulating IGF-1. Estradiol 44-53 insulin like growth factor 1 Bos taurus 178-183 24166993-3 2014 Treatment of feedlot steers with a combined estradiol (E2) and trenbolone acetate (TBA) implant results in an increased number of muscle satellite cells, increased expression of IGF-1 mRNA in muscle tissue, and increased levels of circulating IGF-1. Estradiol 44-53 insulin like growth factor 1 Bos taurus 243-248 24292258-12 2014 These results indicate that chronic use of estradiol after infarction attenuates cardiac fibrosis by inhibiting RhoA/ROCK/cofilin pathway, which is exerted through membrane ERalpha-mediated receptor mechanism. Estradiol 43-52 estrogen receptor 1 Rattus norvegicus 173-180 24685982-0 2014 Hypoxia-induced gene expression of aquaporin-4, cyclooxygenase-2 and hypoxia-inducible factor 1alpha in rat cortical astroglia is inhibited by 17beta-estradiol and progesterone. Estradiol 143-159 aquaporin 4 Rattus norvegicus 35-46 24174573-5 2013 We also determined the effect of inhibition of CART receptor signaling in vivo on estradiol production in future subordinate follicles. Estradiol 82-91 CART prepropeptide Bos taurus 47-51 24055520-11 2013 Furthermore, IGF-II induced expression of 17beta-hydroxysteroid dehydrogenase (HSD) 1 and 3, whereas it reduced estrone sulfotransferase (EST) gene expression, causing enhanced estrone and beta-estradiol production. Estradiol 189-203 insulin like growth factor 2 Homo sapiens 13-19 24180323-6 2013 RESULTS: Single-cell real-time RT-PCR analysis showed that 17beta-estradiol (E2) replacement (once daily for 4 days) selectively down-regulated Kv4.2 mRNA levels in the PVN-RVLM neurons of ovariectomized female rats. Estradiol 59-75 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 144-149 24084383-5 2013 In the present study, we showed that excessive 17beta-estradiol could promote the migration of MCF-7 breast cancer cells and up-regulate the expression of MRTF-A, myosin regulatory light chain 9 (MYL9), and cysteine-rich angiogenic inducer 61 (CYR61). Estradiol 47-63 cellular communication network factor 1 Homo sapiens 207-242 24084383-5 2013 In the present study, we showed that excessive 17beta-estradiol could promote the migration of MCF-7 breast cancer cells and up-regulate the expression of MRTF-A, myosin regulatory light chain 9 (MYL9), and cysteine-rich angiogenic inducer 61 (CYR61). Estradiol 47-63 cellular communication network factor 1 Homo sapiens 244-249 24036251-8 2013 Although no significant changes were measured in uterine blood or lymphatic vascular densities, VEGFR-3 neutralization reduced serum and ovarian estradiol concentrations during gestation. Estradiol 145-154 FMS-like tyrosine kinase 4 Mus musculus 96-103 23933164-0 2013 Anticancer effect of genistein on BG-1 ovarian cancer growth induced by 17 beta-estradiol or bisphenol A via the suppression of the crosstalk between estrogen receptor alpha and insulin-like growth factor-1 receptor signaling pathways. Estradiol 72-89 estrogen receptor 1 (alpha) Mus musculus 150-173 23375982-0 2013 Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. Estradiol 88-97 HOX transcript antisense RNA Homo sapiens 49-55 23375982-5 2013 We also demonstrated that HOTAIR is transcriptionally induced by estradiol (E2). Estradiol 65-74 HOX transcript antisense RNA Homo sapiens 26-32 23883819-6 2013 We detected that estradiol regulates expression of Ikbkg in DCs and modulates nuclear factor-kappab translocation to the nucleus, thus explaining the reduced DC function observed during ovulation. Estradiol 17-26 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 51-56 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Estradiol 96-110 glutathione peroxidase 4 Homo sapiens 273-277 24027494-0 2013 Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation. Estradiol 76-85 progesterone receptor membrane component 1 Homo sapiens 0-6 23886572-5 2013 At seven days post-injury, estradiol, tamoxifen and estradiol plus tamoxifen reduced the number of resident and proliferative NG2 and reactive astrocyte vimentin+ cells. Estradiol 27-36 chondroitin sulfate proteoglycan 4 Rattus norvegicus 126-129 23886572-5 2013 At seven days post-injury, estradiol, tamoxifen and estradiol plus tamoxifen reduced the number of resident and proliferative NG2 and reactive astrocyte vimentin+ cells. Estradiol 52-61 chondroitin sulfate proteoglycan 4 Rattus norvegicus 126-129 23842721-2 2013 Two polymorphisms of the CYP1A1 gene-A4889G and T6235C-are known to affect activation of estrone and estradiol and to deregulate concentration of highly active tamoxifen metabolites. Estradiol 101-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 23592396-7 2013 17beta-estradiol, an ER ligand, positively regulated the mitoxantrone-induced increase of Abcg2 expression. Estradiol 0-16 ATP binding cassette subfamily G member 2 Rattus norvegicus 90-95 23828038-2 2013 More specifically, ERalpha represses a cytochrome P450-encoding gene (CYP1A1) that converts cellular estradiol into a metabolite that inhibits the cell cycle, while it has no effect on a P450-encoding gene (CYP1B1) that converts estrodiol into a genotoxic product. Estradiol 101-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 23769242-0 2013 17beta-Estradiol inhibits HIV-1 by inducing a complex formation between beta-catenin and estrogen receptor alpha on the HIV promoter to suppress HIV transcription. Estradiol 0-16 catenin beta 1 Homo sapiens 72-84 23769242-3 2013 We demonstrate that 17beta-estradiol, in an ERalpha dependent manner, inhibits HIV replication by activating beta-catenin signaling. Estradiol 20-36 catenin beta 1 Homo sapiens 109-121 23769242-4 2013 Specifically, we show for the first time that 17beta-estradiol induces a complex formation between ERalpha and beta-catenin which tether on the HIV LTR at -143nt site from +1 start site of HIV transcription to repress HIV promoter activity. Estradiol 46-62 catenin beta 1 Homo sapiens 111-123 24300204-16 2013 And 17beta-estradiol increases its expression in an ERalpha-dependent manner. Estradiol 4-20 estrogen receptor 1 Rattus norvegicus 52-59 23414458-10 2013 The high expression of BDNF was restored in OVX Rln(+/-) mice by 17beta-estradiol treatment, suggesting that Rln(+/-) mice respond differently to an altered estradiol state than WT controls. Estradiol 65-81 brain derived neurotrophic factor Mus musculus 23-27 23610132-0 2013 17beta-estradiol rapidly attenuates P2X3 receptor-mediated peripheral pain signal transduction via ERalpha and GPR30. Estradiol 0-16 purinergic receptor P2X 3 Rattus norvegicus 36-40 23610132-0 2013 17beta-estradiol rapidly attenuates P2X3 receptor-mediated peripheral pain signal transduction via ERalpha and GPR30. Estradiol 0-16 estrogen receptor 1 Rattus norvegicus 99-106 23610132-0 2013 17beta-estradiol rapidly attenuates P2X3 receptor-mediated peripheral pain signal transduction via ERalpha and GPR30. Estradiol 0-16 G protein-coupled estrogen receptor 1 Rattus norvegicus 111-116 23610132-3 2013 The results showed that 17beta-estradiol (E2) rapidly inhibited pain induced by alpha,beta-methylene ATP (alpha,beta-me-ATP), a P2X1 and P2X3 receptor agonist in ovariectomized rats and normal rats in diestrus. Estradiol 24-40 purinergic receptor P2X 3 Rattus norvegicus 137-141 23219224-12 2013 Treatment with estradiol for 2 days also reduced the levels of the G-protein coupled estrogen receptor GPR30, possibly limiting to the ability of estradiol to produce only a partial desensitization response. Estradiol 15-24 G protein-coupled estrogen receptor 1 Rattus norvegicus 103-108 23219224-12 2013 Treatment with estradiol for 2 days also reduced the levels of the G-protein coupled estrogen receptor GPR30, possibly limiting to the ability of estradiol to produce only a partial desensitization response. Estradiol 146-155 G protein-coupled estrogen receptor 1 Rattus norvegicus 103-108 23825704-1 2013 Many studies have reported proliferative, differentiating or protective effects of estradiol, notably through estrogen receptor alpha (ERalpha). Estradiol 83-92 estrogen receptor 1 Rattus norvegicus 135-142 23261660-2 2013 Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of the canonical Wnt signaling pathway, and simultaneously inducing pro-survival Wnt/beta-Catenin signaling in hippocampal neurons. Estradiol 47-49 catenin beta 1 Homo sapiens 293-305 23261660-4 2013 In this review, we will briefly summarize the canonical Wnt signaling pathway, highlight the current literature linking alterations of Dkk1 and Wnt/beta-Catenin signaling with neurological disease, and discuss E2"s role in maintaining the delicate balance of Dkk1 and Wnt/beta-Catenin signaling in the adult brain. Estradiol 210-212 catenin beta 1 Homo sapiens 272-284 23434684-0 2013 beta-Estradiol-dependent activation of the JAK/STAT pathway requires p/CIP and CARM1. Estradiol 0-14 nuclear receptor coactivator 3 Homo sapiens 69-74 23434684-3 2013 We have shown, using a ChIP-on-chip approach, that in response to stimulation with 17beta-estradiol (E2), the p/CIP/CARM1 complex is recruited to 204 proximal promoters in MCF-7 cells. Estradiol 83-99 nuclear receptor coactivator 3 Homo sapiens 110-115 22983832-7 2013 In a mixed-model for leptin that adjusted for insulin, estradiol, and fat mass, race was significantly associated with leptin (p < 0.0001). Estradiol 55-64 leptin Homo sapiens 119-125 23430591-0 2013 17beta-estradiol suppresses the macrophage foam cell formation associated with SOCS3. Estradiol 0-16 suppressor of cytokine signaling 3 Mus musculus 79-84 23843844-6 2013 Leptin significantly inhibited the antiestrogenic effect of tamoxifen in both cells only under beta-estradiol (E2) (20 nM) conditions. Estradiol 95-109 leptin Homo sapiens 0-6 23225083-0 2013 The role of activation functions 1 and 2 of estrogen receptor-alpha for the effects of estradiol and selective estrogen receptor modulators in male mice. Estradiol 87-96 estrogen receptor 1 (alpha) Mus musculus 44-67 23499826-3 2013 Estradiol enhanced BMP-4-induced Runx2, osterix, ALP and osteocalcin expression in MC3T3-E1 cells. Estradiol 0-9 bone gamma-carboxyglutamate protein 2 Mus musculus 57-68 23805516-0 2013 [Interference of testosterone synthesis through HPGA and ERalpha pathway after 17beta-estradiol exposure to regulate spermatogenesis]. Estradiol 79-95 estrogen receptor 1 Rattus norvegicus 57-64 23428580-10 2013 Real-time PCR analysis demonstrated that 17beta-estradiol (E2) and transforming growth factor beta1 increase and decrease Nmb mRNA expression levels respectively. Estradiol 41-57 neuromedin B Rattus norvegicus 122-125 23313114-7 2013 Co-incubation with CART reduced the BMP2-stimulated increase in granulosa cell estradiol production. Estradiol 79-88 CART prepropeptide Bos taurus 19-23 23419687-11 2013 As regards ER levels, estradiol increased the ERalpha67 quantity diminished by late ovariectomy, while genistein did the same with the other ERalpha isoform, ERalpha46, highlighting drug-specific differences in expression changes for both isoforms. Estradiol 22-31 estrogen receptor 1 Rattus norvegicus 46-53 23549616-0 2013 Upregulation of SIRT1 by 17beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1. Estradiol 25-41 NEDD4 E3 ubiquitin protein ligase Homo sapiens 112-119 23348370-3 2013 Therefore, we tested the hypothesis that ELA induces visceral hypersensitivity through a sexually dimorphic mechanism mediated via estradiol. Estradiol 131-140 apelin receptor early endogenous ligand Homo sapiens 41-44 23348370-12 2013 PERSPECTIVE: This article directly implicates a critical role for ovarian hormones in maintaining visceral hypersensitivity following ELA, specifically identifying the activational effect of estradiol as a key modulator of visceral sensitivity. Estradiol 191-200 apelin receptor early endogenous ligand Homo sapiens 134-137 23211559-10 2013 Treatment with estradiol also increased HIF-1alpha and VEGF protein levels in the ischemic ipsilateral SVZ at all time points examined (P<0.05). Estradiol 15-24 vascular endothelial growth factor A Rattus norvegicus 55-59 23211559-11 2013 These findings indicate that post-stroke estradiol administration promotes SVZ neurogenesis in rats, probably by increasing HIF-1alpha and VEGF protein expression. Estradiol 41-50 vascular endothelial growth factor A Rattus norvegicus 139-143 22837389-6 2013 Estradiol also increased enzyme activities of CYP2C9 and CYP2E1 without affecting the mRNA expression levels by unknown mechanisms. Estradiol 0-9 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 46-52 23264616-11 2013 Previous treatment with estradiol resulted in lasting increases in levels of IGF-I receptors and phosphorylation of ERK/MAPK, a downstream signaling molecule of both ERalpha and IGF-I receptors, and increased levels of the ERalpha-regulated protein, choline acetyltransferase. Estradiol 24-33 estrogen receptor 1 Rattus norvegicus 166-173 23264616-11 2013 Previous treatment with estradiol resulted in lasting increases in levels of IGF-I receptors and phosphorylation of ERK/MAPK, a downstream signaling molecule of both ERalpha and IGF-I receptors, and increased levels of the ERalpha-regulated protein, choline acetyltransferase. Estradiol 24-33 insulin-like growth factor 1 Rattus norvegicus 178-183 23264616-11 2013 Previous treatment with estradiol resulted in lasting increases in levels of IGF-I receptors and phosphorylation of ERK/MAPK, a downstream signaling molecule of both ERalpha and IGF-I receptors, and increased levels of the ERalpha-regulated protein, choline acetyltransferase. Estradiol 24-33 estrogen receptor 1 Rattus norvegicus 223-230 23264616-13 2013 Results indicate that activation of IGF-I receptors is necessary for prior estradiol exposure to exert lasting impact on the hippocampus and memory. Estradiol 75-84 insulin-like growth factor 1 Rattus norvegicus 36-41 23116217-4 2013 METHODS: MCF-7 cells overexpressing PGRMC1 were stimulated with DNG, medroxyprogesterone acetate (MPA), norethisterone (NET) and progesterone (P) as well as sequentially and continuously combined with estradiol (E2). Estradiol 201-210 progesterone receptor membrane component 1 Homo sapiens 36-42 22927007-2 2013 We show here that 17beta-estradiol (E2)-induced apoptosis of bone-resorbing osteoclasts is mediated by cleavage and solubilization of osteoblast-expressed Fas ligand (FasL). Estradiol 18-34 Fas ligand Homo sapiens 155-165 22927007-2 2013 We show here that 17beta-estradiol (E2)-induced apoptosis of bone-resorbing osteoclasts is mediated by cleavage and solubilization of osteoblast-expressed Fas ligand (FasL). Estradiol 18-34 Fas ligand Homo sapiens 167-171 23158749-10 2013 Leptin positively correlated with BMI (r = 0.534; P = .001), estradiol (r = 0.354; P = .02), and TSH (r = 0.374; P = .02). Estradiol 61-70 leptin Homo sapiens 0-6 23544495-0 2013 [Influence of pertussis toxin on GPER-mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17beta-estradiol in endometrial carcinoma cells]. Estradiol 129-145 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 61-90 23544495-1 2013 OBJECTIVE: To investigate the influence of pertussis toxin (PTX) on G protein-coupled estrogen receptor (GPER)-mediated activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling activated by 17beta-estradiol (17beta-E2) in endometrial carcinoma cells. Estradiol 217-233 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 134-163 22678724-3 2013 Furthermore, estrogenic support of SNB dendrite growth is mediated by estrogen action at the target musculature, inhibited by estrogen receptor (ER) blockade at the muscle and supported by local estradiol treatment. Estradiol 195-204 estrogen receptor 1 Rattus norvegicus 145-147 23211705-8 2013 Hormone analysis showed that the CRH group had lower levels of 17beta-estradiol, progesterone, and beta-human chorionic gonadotropin as the culture progressed, in comparison with the other two groups. Estradiol 63-79 corticotropin releasing hormone Homo sapiens 33-36 22987058-0 2013 Regulation of ERalpha protein expression by 17beta-estradiol in cultured neurons of hypothalamic ventromedial nucleus. Estradiol 44-60 estrogen receptor 1 Rattus norvegicus 14-21 22987058-6 2013 Measurements of ERalpha immunofluorescence revealed that both supraphysiological and physiological concentrations of 17beta-estradiol increase the expression of ERalpha. Estradiol 117-133 estrogen receptor 1 Rattus norvegicus 16-23 22987058-6 2013 Measurements of ERalpha immunofluorescence revealed that both supraphysiological and physiological concentrations of 17beta-estradiol increase the expression of ERalpha. Estradiol 117-133 estrogen receptor 1 Rattus norvegicus 161-168 23571598-5 2013 Indeed, STX was able to augment sexual receptivity in female rats given a sub-behavioral dose of estradiol. Estradiol 97-106 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Rattus norvegicus 8-11 22858193-6 2013 SIE treatment was more effective than vitamin D3 or 17beta-estradiol in inhibiting increases in serum tumor necrosis factor-alpha levels and osteoblast osteoprotegerin expression. Estradiol 52-68 TNF receptor superfamily member 11B Rattus norvegicus 152-167 23451081-6 2013 In the ovariectomized uterus, Prss23 was moderately and Prss35 was dramatically downregulated by progesterone and 17beta-estradiol. Estradiol 114-130 protease, serine 23 Mus musculus 30-36 23143558-4 2012 In this study, we first evaluated the effects of estradiol (E2) and its antagonist ICI182,780 on the expression of miRNAs (miR-31, miR-155 and miR-135b) using COLO205, SW480 and MCF-7 cell lines, followed by examining the association of tissue miRNA expression and serum E2 levels using samples collected from 18 colorectal cancer patients. Estradiol 49-58 microRNA 31 Homo sapiens 123-129 23070546-6 2012 This effect was completely blocked by BZA as were E(2)-stimulated expression of PR, pS2 (trefoil factor 1), cMyc, and AREG; the enhancement of Ki67 and proliferating cell nuclear antigen (PCNA); and the antiapoptotic effect. Estradiol 50-54 trefoil factor 1 Mus musculus 84-87 23070546-6 2012 This effect was completely blocked by BZA as were E(2)-stimulated expression of PR, pS2 (trefoil factor 1), cMyc, and AREG; the enhancement of Ki67 and proliferating cell nuclear antigen (PCNA); and the antiapoptotic effect. Estradiol 50-54 trefoil factor 1 Mus musculus 89-105 22422661-4 2012 After 4 weeks of IPL feeding at 500 mg/day/kg body weight (OVX500), plasma 17beta-estradiol concentrations were significantly higher (+25%, p < 0.05), whereas plasma triglyceride levels were significantly lower in OVX mice (-15%, p < 0.05) compared with controls. Estradiol 75-91 pleckstrin homology like domain, family A, member 2 Mus musculus 17-20 22729071-6 2012 Treatment of HES cells with estradiol or phorbyl 12-myristate-13-acetate increased the release of EMMPRIN-containing microvesicles. Estradiol 28-37 basigin (Ok blood group) Homo sapiens 98-105 22975709-0 2012 Estradiol inhibits the activity of proton-coupled amino acid transporter PAT1 expressed in Xenopus oocytes. Estradiol 0-9 solute carrier family 36 member 1 Homo sapiens 73-77 22975709-5 2012 The effects of estradiol on the activity of PAT1 were investigated. Estradiol 15-24 solute carrier family 36 member 1 Homo sapiens 44-48 22975709-8 2012 A concentration-dependent outwards current of PAT1 was also detected by the presence of beta-estradiol. Estradiol 88-102 solute carrier family 36 member 1 Homo sapiens 46-50 22796107-1 2012 Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) which bind estradiol with similar affinities and mediate the effects of estrogen throughout the body. Estradiol 145-154 estrogen receptor 1 (alpha) Mus musculus 64-87 22796107-1 2012 Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) which bind estradiol with similar affinities and mediate the effects of estrogen throughout the body. Estradiol 145-154 estrogen receptor 1 (alpha) Mus musculus 89-96 23153703-8 2012 Estradiol (0.2 ng/ml) and P(4) (200 ng/ml) increased leptin secretion by luteal cells. Estradiol 0-9 leptin Homo sapiens 53-59 21304949-6 2011 Moreover, 25 HC exhibits the ERalpha-dependent ability like 17 beta-estradiol (E2) to inhibit the up-regulation of HIF-1alpha and connective tissue growth factor by hypoxic conditions in cardiomyocytes and rat heart preparations and to prevent the hypoxia-induced apoptosis. Estradiol 60-77 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 115-125 21298063-6 2011 These morphological changes in the glands of VDR KO mice are associated with ovarian failure and reduced serum 17beta-estradiol. Estradiol 111-127 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 45-48 21446962-3 2011 The key component of this assay system, an estradiol-reporter enzyme conjugate, was prepared by covalently binding beta-estradiol-6-(O-carboxymethyl)oxime to glucose-6-phosphate dehydrogenase (G6PDH) by an N-hydroxysuccinimide-enhanced, carbodiimide-mediated coupling reaction. Estradiol 43-52 glucose-6-phosphate dehydrogenase Homo sapiens 158-191 21446962-3 2011 The key component of this assay system, an estradiol-reporter enzyme conjugate, was prepared by covalently binding beta-estradiol-6-(O-carboxymethyl)oxime to glucose-6-phosphate dehydrogenase (G6PDH) by an N-hydroxysuccinimide-enhanced, carbodiimide-mediated coupling reaction. Estradiol 43-52 glucose-6-phosphate dehydrogenase Homo sapiens 193-198 20921303-5 2011 In addition, the effect of 17-beta-estradiol and progesterone on CYP1A2 mRNA levels was assessed using rat hepatocytes, and the effect of estrogens or progesterone on CYP1A2 activity in vitro was tested. Estradiol 27-44 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 65-71 19932013-13 2011 Serum testosterone, estradiol, PAcP, citric acid levels, AR and ER-alpha expressions were significantly decreased while H(2)O(2) generation, LPO, ER-beta were increased in PCB-exposed animals. Estradiol 20-29 pyruvate carboxylase Rattus norvegicus 172-175 22174920-0 2011 Inhibition of the mitochondrial enzyme ABAD restores the amyloid-beta-mediated deregulation of estradiol. Estradiol 95-104 hydroxysteroid 17-beta dehydrogenase 10 Homo sapiens 39-43 21203528-4 2010 Moreover, in presence of FAs, the E(2)-induced recruitment of the EAB1 co-activator peptide to ERalpha is masked and the E(2)-induced estrogen response element (ERE)-mediated transactivation is inhibited. Estradiol 34-38 EYA transcriptional coactivator and phosphatase 2 Homo sapiens 66-70 21351254-0 2010 Protective role of 17 beta-estradiol on medulloblastoma development in Patched 1 heterozygous mice. Estradiol 19-36 patched 1 Mus musculus 71-80 20568229-11 2010 We also observed that, CCL18 interferes with the activation of GPR30 by previously identified ligands (17beta-estradiol and chemical agonists). Estradiol 103-119 G protein-coupled estrogen receptor 1 Homo sapiens 63-68 20675569-4 2010 However, the results presented here indicate that estradiol derivatives down-regulate CYP2C19 expression via estrogen receptor (ER) alpha, which interacts with the newly identified ER-binding half site [estrogen response element (ERE)] at the position -151/-147 in the CYP2C19 promoter. Estradiol 50-59 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 86-93 20675569-4 2010 However, the results presented here indicate that estradiol derivatives down-regulate CYP2C19 expression via estrogen receptor (ER) alpha, which interacts with the newly identified ER-binding half site [estrogen response element (ERE)] at the position -151/-147 in the CYP2C19 promoter. Estradiol 50-59 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 269-276 20675569-5 2010 In gene reporter experiments in Huh-7 hepatoma cells, the activity of the luciferase construct carrying a 1.6-kb long CYP2C19 promoter fragment cotransfected with ERalpha was down-regulated upon treatment with 17beta-estradiol (EE) or 17alpha-ethinylestradiol (ETE) at half-maximum concentrations of 10(-7) and 10(-8) M, respectively. Estradiol 210-226 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 118-125 20880986-7 2010 Recruitment of FAK and N-WASP is necessary for cell migration and invasion induced by 17beta-estradiol in breast cancer cells. Estradiol 86-102 WASP like actin nucleation promoting factor Homo sapiens 23-29 20654686-4 2010 We show that 17beta-estradiol or GPR30-specific agonists decrease TLR4 expression on macrophages within 10-60 min and such effects were abolished following GPR30 knockdown. Estradiol 13-29 G protein-coupled estrogen receptor 1 Mus musculus 156-161 20842631-6 2010 Estradiol or estradiol metabolites may contribute to this effect because coincubation with the estrogen receptor (ER) antagonist fulvestrant (ICI 182780) abolished the repressive effects on Shp expression. Estradiol 0-9 nuclear receptor subfamily 0, group B, member 2 Mus musculus 190-193 20842631-6 2010 Estradiol or estradiol metabolites may contribute to this effect because coincubation with the estrogen receptor (ER) antagonist fulvestrant (ICI 182780) abolished the repressive effects on Shp expression. Estradiol 13-22 nuclear receptor subfamily 0, group B, member 2 Mus musculus 190-193 20685851-4 2010 Additionally, both E(2) and dihydrotestosterone prevented H(2)O(2)-induced apoptosis by a mechanism that involved attenuation of p66(shc) resulting from decreased phosphorylation of PKCbeta. Estradiol 19-23 SHC adaptor protein 1 Homo sapiens 133-136 20843342-0 2010 Dietary supplementation of soy germ phytoestrogens or estradiol improves spatial memory performance and increases gene expression of BDNF, TrkB receptor and synaptic factors in ovariectomized rats. Estradiol 54-63 brain-derived neurotrophic factor Rattus norvegicus 133-137 20843342-8 2010 Estradiol or the high dose of phytoestrogens treatment significantly increased BDNF concentration and the mRNA levels for BDNF and its TrkB receptors as well as the synaptic formation proteins, synaptophysin, spinophilin, synapsin 1 and PSD-95, in the hippocampal tissue of the experimental animals. Estradiol 0-9 brain-derived neurotrophic factor Rattus norvegicus 79-83 20843342-8 2010 Estradiol or the high dose of phytoestrogens treatment significantly increased BDNF concentration and the mRNA levels for BDNF and its TrkB receptors as well as the synaptic formation proteins, synaptophysin, spinophilin, synapsin 1 and PSD-95, in the hippocampal tissue of the experimental animals. Estradiol 0-9 brain-derived neurotrophic factor Rattus norvegicus 122-126 20843342-8 2010 Estradiol or the high dose of phytoestrogens treatment significantly increased BDNF concentration and the mRNA levels for BDNF and its TrkB receptors as well as the synaptic formation proteins, synaptophysin, spinophilin, synapsin 1 and PSD-95, in the hippocampal tissue of the experimental animals. Estradiol 0-9 synaptophysin Rattus norvegicus 194-207 20843342-8 2010 Estradiol or the high dose of phytoestrogens treatment significantly increased BDNF concentration and the mRNA levels for BDNF and its TrkB receptors as well as the synaptic formation proteins, synaptophysin, spinophilin, synapsin 1 and PSD-95, in the hippocampal tissue of the experimental animals. Estradiol 0-9 synapsin I Rattus norvegicus 222-232 20504098-6 2010 Estradiol induces growth factors" activation, receptor activator of nuclear factor kappa B ligand (RANKL) production inhibition and is mainly referred to antiresorptive activity. Estradiol 0-9 TNF superfamily member 11 Homo sapiens 46-97 20504098-6 2010 Estradiol induces growth factors" activation, receptor activator of nuclear factor kappa B ligand (RANKL) production inhibition and is mainly referred to antiresorptive activity. Estradiol 0-9 TNF superfamily member 11 Homo sapiens 99-104 20644008-8 2010 The ability of estradiol to enhance capillary formation, increase expression of HO-1, and augment phosphorylation of extracellular signal-regulated kinase 1/2, Akt, and vascular endothelial growth factor receptor 2 was mimicked by its cell-impermeable analog BSA estradiol. Estradiol 15-24 kinase insert domain receptor Homo sapiens 169-214 20644008-8 2010 The ability of estradiol to enhance capillary formation, increase expression of HO-1, and augment phosphorylation of extracellular signal-regulated kinase 1/2, Akt, and vascular endothelial growth factor receptor 2 was mimicked by its cell-impermeable analog BSA estradiol. Estradiol 263-272 kinase insert domain receptor Homo sapiens 169-214 20522564-1 2010 Cytochrome P4501 (CYP1) and CYP3A proteins are primarily responsible for the metabolism of 17beta-estradiol (E(2)) in mammals. Estradiol 91-107 peptidylprolyl isomerase Aa (cyclophilin A) Danio rerio 18-22 20566641-5 2010 We also show that 17beta-estradiol binds specifically to the intact hepatocyte plasma membrane through an interaction that is competed by an excess of atrial natriuretic peptide but also shows many similarities to the pharmacological characteristics of the putative gamma-adrenergic receptor. Estradiol 18-34 natriuretic peptide A Rattus norvegicus 151-177 20566641-6 2010 We, therefore, propose that the observed rapid signaling effects of 17beta-estradiol are mediated either through the guanylyl cyclase A receptor for atrial natriuretic peptide or through the gamma-adrenergic receptor, which is either itself a transmembrane guanylyl cyclase or activates a transmembrane guanylyl cyclase through cross-talk signaling. Estradiol 68-84 natriuretic peptide A Rattus norvegicus 149-175 20493928-4 2010 Moreover, 17beta-estradiol resulted in elevated brain levels of transthyretin, which inhibits aggregation of Abeta into plaques; though the insulin-degrading enzyme, which breaks down Abeta, was significantly reduced. Estradiol 10-26 transthyretin Homo sapiens 64-77 20493928-4 2010 Moreover, 17beta-estradiol resulted in elevated brain levels of transthyretin, which inhibits aggregation of Abeta into plaques; though the insulin-degrading enzyme, which breaks down Abeta, was significantly reduced. Estradiol 10-26 insulin degrading enzyme Homo sapiens 140-164 20735828-10 2010 Lungs of OVx allergic rats significantly increased the E-selectin expression, an effect prevented by estradiol but not by progesterone treatment. Estradiol 101-110 selectin E Rattus norvegicus 55-65 20553875-8 2010 Chronic estradiol treatment modulated the neural response in some regions: less c-Fos was induced in the superior vestibular nucleus and locus coeruleus after estradiol replacement; estradiol treatment eliminated the asymmetry of c-Fos expression in the locus coeruleus and supragenualis nucleus, created an asymmetry in the prepositus nucleus and reversed the asymmetry in the parabrachial nucleus. Estradiol 8-17 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 80-85 20553875-8 2010 Chronic estradiol treatment modulated the neural response in some regions: less c-Fos was induced in the superior vestibular nucleus and locus coeruleus after estradiol replacement; estradiol treatment eliminated the asymmetry of c-Fos expression in the locus coeruleus and supragenualis nucleus, created an asymmetry in the prepositus nucleus and reversed the asymmetry in the parabrachial nucleus. Estradiol 8-17 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 230-235 20549137-8 2010 These data show that hypophagia induced by estradiol treatment is associated with reduced hypothalamic expression of orexigenic peptides such as NPY, AgRP and orexin A, and increased expression of the anorexigenic mediators MC4-R, LepRb and CRH. Estradiol 43-52 melanocortin 4 receptor Rattus norvegicus 224-229 20538789-0 2010 17beta-estradiol down-regulates lipopolysaccharide-induced MCP-1 production and cell migration in vascular smooth muscle cells. Estradiol 0-16 chemokine (C-C motif) ligand 2 Mus musculus 59-64 20538789-5 2010 On the contrary, 17beta-estradiol (E(2)) inhibits LPS-induced MCP-1 production in a time- and dose-dependent manner, which is related to the suppression of p65 translocation to nucleus. Estradiol 17-33 chemokine (C-C motif) ligand 2 Mus musculus 62-67 19931550-1 2010 Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. Estradiol 129-145 G protein-coupled estrogen receptor 1 Homo sapiens 58-87 19931550-1 2010 Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. Estradiol 129-145 G protein-coupled estrogen receptor 1 Homo sapiens 89-93 19931550-1 2010 Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. Estradiol 129-145 G protein-coupled estrogen receptor 1 Homo sapiens 113-118 20615255-4 2010 METHODS: We initially described the distribution of lymphatic vessels (Lyve-1, podoplanin, VEGFR-3) and VEGF-D expression in the mouse uterus during the estrous cycle, early pregnancy and in response to estradiol-17beta and progesterone using immunohistochemistry. Estradiol 203-219 vascular endothelial growth factor D Mus musculus 104-110 20615255-8 2010 VEGF-D immunoexpression was slightly but significantly higher in estrus relative to diestrus; and in estradiol-17beta treated mice relative to vehicle or progesterone treated mice. Estradiol 101-117 vascular endothelial growth factor D Mus musculus 0-6 20683028-2 2010 Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. Estradiol 182-200 N-acetyltransferase 2 Homo sapiens 33-53 20683028-2 2010 Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestradiol. Estradiol 182-200 N-acetyltransferase 2 Homo sapiens 55-59 20444943-0 2010 Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol. Estradiol 162-171 androgen receptor Mus musculus 12-29 20484461-8 2010 Finally, OVX apo A-IV knockout mice had a smaller feeding response to estradiol because they ate significantly more food and gained more body weight than OVX wild-type controls during the period of cyclic estradiol replacement. Estradiol 70-79 apolipoprotein A-IV Mus musculus 13-21 20456608-12 2010 Third, oestradiol causes rapid, direct, excitatory action in GnRH neurones and this action of oestradiol appears to be mediated through a membrane receptor, such as G-protein coupled receptor 30. Estradiol 7-17 G protein-coupled estrogen receptor 1 Homo sapiens 165-194 20456608-12 2010 Third, oestradiol causes rapid, direct, excitatory action in GnRH neurones and this action of oestradiol appears to be mediated through a membrane receptor, such as G-protein coupled receptor 30. Estradiol 94-104 G protein-coupled estrogen receptor 1 Homo sapiens 165-194 20403413-6 2010 Among these proteins, levels of protein phosphatase 2A (PP2A) and astrocytic phosphoprotein PEA-15 were significantly decreased in the oil-treated group in comparison to the estradiol-treated group. Estradiol 174-183 protein phosphatase 2, regulatory subunit A, alpha Mus musculus 56-60 20371658-3 2010 Whereas this cancer occurs predominantly in postmenopausal women lacking estrogen production by ovaries, the conversion of adrenal androgen-estrogen precursors to estradiol (E(2)), estrone (E(1)), and its sulfate (E(1)-S) has been well documented in peripheral tissues. Estradiol 163-172 cystatin 12, pseudogene Homo sapiens 174-178 20138962-2 2010 17beta-estradiol (E2) is reversibly oxidized to estrone (E1) and both E2 and E1 can be irreversibly converted to estriol (E3), which also originates directly from androstenedione. Estradiol 0-16 small nucleolar RNA, C/D box 12C Homo sapiens 70-79 20124397-0 2010 Interplay of phase II enzymes and transporters in futile cycling: influence of multidrug resistance-associated protein 2-mediated excretion of estradiol 17beta-D-glucuronide and its 3-sulfate metabolite on net sulfation in perfused TR(-) and Wistar rat liver preparations. Estradiol 143-152 ATP binding cassette subfamily C member 2 Rattus norvegicus 79-120 19953602-10 2010 Estradiol affected gene expression of aggrecan (AGC)1, MMP2, MMP14, tissue inhibitor of metalloproteinase (TIMP)2, TGFB2, and TGFB3. Estradiol 0-9 TIMP metallopeptidase inhibitor 2 Bos taurus 107-113 19953602-12 2010 Repair experiment: Estradiol affected IA-induced changes in expression of collagen (COL)2, MMP2, MMP3, MMP13, MMP14, TIMP2, TGFB2, TGFB3, and VEGF. Estradiol 19-28 stromelysin-1 Bos taurus 97-101 19953602-12 2010 Repair experiment: Estradiol affected IA-induced changes in expression of collagen (COL)2, MMP2, MMP3, MMP13, MMP14, TIMP2, TGFB2, TGFB3, and VEGF. Estradiol 19-28 TIMP metallopeptidase inhibitor 2 Bos taurus 117-122 19953602-12 2010 Repair experiment: Estradiol affected IA-induced changes in expression of collagen (COL)2, MMP2, MMP3, MMP13, MMP14, TIMP2, TGFB2, TGFB3, and VEGF. Estradiol 19-28 vascular endothelial growth factor A Bos taurus 142-146 20233295-7 2010 Estrogen withdrawal decreased phosphorylation of eNOS on its positive regulatory site (Ser-1177) and increased eNOS binding to its negative regulator caveolin-1 (without affecting eNOS/HSP90 interaction), and they were both normalized by estradiol replacement. Estradiol 238-247 nitric oxide synthase 3 Rattus norvegicus 49-53 20233295-9 2010 eNOS phosphorylation on its negative regulatory site (Ser-114) was increased in the vagina by estrogen withdrawal and normalized by estradiol replacement, implying that the maintenance of low phosphorylation of eNOS on this site by estradiol may limit eNOS interaction with caveolin-1 and preserve the enzyme"s activity. Estradiol 132-141 nitric oxide synthase 3 Rattus norvegicus 0-4 20233295-9 2010 eNOS phosphorylation on its negative regulatory site (Ser-114) was increased in the vagina by estrogen withdrawal and normalized by estradiol replacement, implying that the maintenance of low phosphorylation of eNOS on this site by estradiol may limit eNOS interaction with caveolin-1 and preserve the enzyme"s activity. Estradiol 232-241 nitric oxide synthase 3 Rattus norvegicus 0-4 20233295-9 2010 eNOS phosphorylation on its negative regulatory site (Ser-114) was increased in the vagina by estrogen withdrawal and normalized by estradiol replacement, implying that the maintenance of low phosphorylation of eNOS on this site by estradiol may limit eNOS interaction with caveolin-1 and preserve the enzyme"s activity. Estradiol 232-241 nitric oxide synthase 3 Rattus norvegicus 211-215 20233295-9 2010 eNOS phosphorylation on its negative regulatory site (Ser-114) was increased in the vagina by estrogen withdrawal and normalized by estradiol replacement, implying that the maintenance of low phosphorylation of eNOS on this site by estradiol may limit eNOS interaction with caveolin-1 and preserve the enzyme"s activity. Estradiol 232-241 nitric oxide synthase 3 Rattus norvegicus 211-215 20332105-0 2010 The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen. Estradiol 132-141 interferon gamma receptor 2 Homo sapiens 86-90 20332105-3 2010 Here, we report that the binding of steroid receptor coactivator-1 (SRC-1) to the AF-1 domain of ERalpha is essential but not sufficient to facilitate synergy between the AF-1 and AF-2 domains, which is required for a full agonistic response to estradiol (E2). Estradiol 245-254 interferon gamma receptor 2 Homo sapiens 82-86 19882681-6 2010 Expression of BRCA-1, p53, p21(WAF), and c-myc was increased by estradiol stimulation and subsequently decreased by melatonin treatment in both cell lines, except for p53 expression in the transfected cell line, thereby proving the antiestrogenic effect of melatonin at molecular level. Estradiol 64-73 BRCA1 DNA repair associated Homo sapiens 14-20 20067569-7 2010 Results indicate 17beta-estradiol may activate the phosphatidylinositol-3-kinase cascade, which subsequently phosphorylates the NR2B subunit, via spinal estrogen receptors ERalpha/ERbeta, to facilitate NMDA-dependent cross-organ sensitization, which is presumed to underlie pelvic viscero-visceral referred pain. Estradiol 17-33 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 128-132 20149813-4 2010 Treatment of L6GNR4 cells with physiological levels of 17beta-estradiol (E2) results in markedly decreased endogenous Fhl1 expression. Estradiol 55-71 four and a half LIM domains 1 Rattus norvegicus 118-122 20237262-11 2010 Acute in vitro treatment of cells from OVX and OVX+E mice with estradiol rapidly increased HVA currents primarily through L- and R-type VGCCs by activating estrogen receptor beta and GPR30, respectively. Estradiol 63-72 G protein-coupled estrogen receptor 1 Mus musculus 183-188 20219117-9 2010 Additionally, adiponectin decreased insulin 10(-8) M-induced, but not basal or IGF-1 10(-8) M-induced secretions of progesterone (P < 0.01) and estradiol (P < 0.05) by GC. Estradiol 147-156 adiponectin, C1Q and collagen domain containing Bos taurus 14-25 19621276-0 2010 Participation of HSP27 in the antiapoptotic action of 17beta-estradiol in skeletal muscle cells. Estradiol 54-70 heat shock protein 1 Mus musculus 17-22 19621276-4 2010 Reverse transcriptase polymerase chain reaction, Western blot, and immunocytochemistry assays showed that 17beta-estradiol induces a time-dependent (5-60 min) increase in the expression of HSP27. Estradiol 106-122 heat shock protein 1 Mus musculus 189-194 19621276-7 2010 17beta-Estradiol abolished caspase-3 cleavage elicited by H(2)O(2). Estradiol 0-16 caspase 3 Mus musculus 27-36 19621276-8 2010 Coimmunoprecipitation assays suggested physical interaction of HSP27 with caspase-3 in presence of estradiol. Estradiol 99-108 heat shock protein 1 Mus musculus 63-68 19621276-8 2010 Coimmunoprecipitation assays suggested physical interaction of HSP27 with caspase-3 in presence of estradiol. Estradiol 99-108 caspase 3 Mus musculus 74-83 19621276-10 2010 Then, this study suggests that HSP27 plays a new role in the antiapoptotic action triggered by 17beta-estradiol by modulating caspase-3 activity and stabilizing ERbeta in skeletal muscle cells. Estradiol 95-111 heat shock protein 1 Mus musculus 31-36 19621276-10 2010 Then, this study suggests that HSP27 plays a new role in the antiapoptotic action triggered by 17beta-estradiol by modulating caspase-3 activity and stabilizing ERbeta in skeletal muscle cells. Estradiol 95-111 caspase 3 Mus musculus 126-135 20045459-6 2010 Additionally, hSF-1 suppressed proliferation and promoted apoptosis of SKOV-3 cells and suppressed SKOV-3 cell growth induced by ERalpha and estradiol. Estradiol 141-150 splicing factor 1 Homo sapiens 14-19 20045459-8 2010 Human SF-1 may decrease OSE cancer cell numbers directly by apoptosis, and indirectly by opposing estradiol-induced proliferation. Estradiol 98-107 splicing factor 1 Homo sapiens 6-10 20031206-3 2010 Using cDNA microarray, we previously observed that Id-1 was upregulated in uteri from ovariectomized (OVX) mice exposed to 17beta-estradiol (E2). Estradiol 123-139 inhibitor of DNA binding 1, HLH protein Mus musculus 51-55 20064537-1 2010 The naturally occurring steroid dehydroepiandrosterone (DHEA) is reported to reduce glial fibrillary acidic protein (GFAP) overexpression in a model of reactive gliosis due to its conversion to estradiol by the enzyme aromatase. Estradiol 194-203 glial fibrillary acidic protein Homo sapiens 84-115 20064537-1 2010 The naturally occurring steroid dehydroepiandrosterone (DHEA) is reported to reduce glial fibrillary acidic protein (GFAP) overexpression in a model of reactive gliosis due to its conversion to estradiol by the enzyme aromatase. Estradiol 194-203 glial fibrillary acidic protein Homo sapiens 117-121 19955180-4 2010 Cultures of follicles and primary granulosa cells demonstrated that the level of TSHR is up-regulated and decreased by the gonadotropin-driven cAMP cascade and estradiol production, respectively. Estradiol 160-169 thyroid stimulating hormone receptor Homo sapiens 81-85 20075204-3 2010 Here, we demonstrate that under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a naturally-derived, extracellular matrix. Estradiol 78-87 catechol-O-methyltransferase Mus musculus 151-179 20075204-3 2010 Here, we demonstrate that under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a naturally-derived, extracellular matrix. Estradiol 78-87 catechol-O-methyltransferase Mus musculus 181-185 20151473-9 2010 The endometrial gland number, the uterine epithelial cell height, and the PCNA-positive expression in 17beta-estradiol-treated rats increased compared to that of the control (P<0.01), but not in the CaCl(2) dose groups. Estradiol 102-118 proliferating cell nuclear antigen Rattus norvegicus 74-78 20086172-1 2010 The G protein-coupled receptor GPR30 binds 17beta-estradiol (E(2)) yet differs from classic estrogen receptors (ERalpha and ERbeta). Estradiol 43-59 G protein-coupled estrogen receptor 1 Homo sapiens 31-36 20086172-2 2010 GPR30 can mediate E(2)-induced nongenomic signaling, but its role in ERalpha-positive breast cancer remains unclear. Estradiol 18-22 G protein-coupled estrogen receptor 1 Homo sapiens 0-5 20086172-6 2010 In Ca(2+) mobilization studies, GPR30, but not ERalpha, mediated E(2)-induced Ca(2+) responses because E(2), 4-hydroxytamoxifen (activates GPR30), and G-1, but not DES, elicited cytosolic Ca(2+) increases not only in MCF-7 cells but also in ER-negative SKBr3 cells. Estradiol 65-69 G protein-coupled estrogen receptor 1 Homo sapiens 32-37 20086172-6 2010 In Ca(2+) mobilization studies, GPR30, but not ERalpha, mediated E(2)-induced Ca(2+) responses because E(2), 4-hydroxytamoxifen (activates GPR30), and G-1, but not DES, elicited cytosolic Ca(2+) increases not only in MCF-7 cells but also in ER-negative SKBr3 cells. Estradiol 103-107 G protein-coupled estrogen receptor 1 Homo sapiens 32-37 20085651-6 2010 RESULTS: Several variants on a haplotype block spanning intron 11 to intron 12 of SCARB1 showed significant gene by estradiol interaction affecting serum lipid levels, the strongest for rs838895 with HDL-cholesterol (p=9.2x10(-4)) and triglycerides (p=1.3x10(-3)) and the triglyceride:HDL cholesterol ratio (p=2.7x10(-4)). Estradiol 116-125 scavenger receptor class B member 1 Homo sapiens 82-88 19621387-8 2010 Conversely, 17beta-estradiol (E(2)) increased proliferation and CDC25A and FAS expression along with increased binding of Sp1 to the promoters of the 2 genes. Estradiol 12-28 cell division cycle 25A Homo sapiens 64-70 19621387-8 2010 Conversely, 17beta-estradiol (E(2)) increased proliferation and CDC25A and FAS expression along with increased binding of Sp1 to the promoters of the 2 genes. Estradiol 12-28 fatty acid synthase Homo sapiens 75-78 19796502-6 2010 Moreover, the evaluation of urea synthesis from ammonia and UDP-glucuronosyltransferase 1A1 activity, a newly developed assay using beta-estradiol as substrate, allows the possibility of customizing cell preparation for receptors with urea cycle disorders or Crigler-Najjar Syndrome type I. Estradiol 132-146 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 60-91 19922474-3 2009 Our studies have demonstrated that HOXC13 is transcriptionally activated by the steroid hormone estrogen (17beta-estradiol; E2). Estradiol 106-122 homeobox C13 Homo sapiens 35-41 20046026-0 2009 17Beta-estradiol induces gastrointestinal motility disorder by decreasing CPI-17 phosphorylation via changes in rho-family G-protein Rnd expression in small intestine. Estradiol 0-16 protein phosphatase 1, regulatory (inhibitor) subunit 14A Rattus norvegicus 74-80 20046026-5 2009 17beta-estradiol did not change protein expression levels of RhoA and RhoA-associated coiled coil-forming serine/threonine kinases (ROCKs); however, it upregulated Rnd2 and Rnd3, Rho-family G-proteins that counteract the functions of RhoA, both in vitro and in vivo. Estradiol 0-16 Rho family GTPase 2 Rattus norvegicus 164-168 20046026-6 2009 In organ culture, treatment of ileal tissue with 17beta-estradiol greatly suppressed the carbachol-induced increase in phosphorylation at Thr38 in CPI-17 without altering total CPI-17 protein expression. Estradiol 49-65 protein phosphatase 1, regulatory (inhibitor) subunit 14A Rattus norvegicus 147-153 20046026-7 2009 These results suggest that 17beta-estradiol upregulates Rnd expression to inhibit the RhoA-mediated Ca(2+) sensitization of contractile mechanisms, which are mediated by CPI-17 phosphorylation in ileal smooth muscle. Estradiol 27-43 ras homolog family member A Rattus norvegicus 86-90 20046026-7 2009 These results suggest that 17beta-estradiol upregulates Rnd expression to inhibit the RhoA-mediated Ca(2+) sensitization of contractile mechanisms, which are mediated by CPI-17 phosphorylation in ileal smooth muscle. Estradiol 27-43 protein phosphatase 1, regulatory (inhibitor) subunit 14A Rattus norvegicus 170-176 19726745-8 2009 Moreover, both receptors mediate the E(2)-induced activation of p38, which, in turn, affects the expression of myogenin and myosin heavy chain. Estradiol 37-41 myogenin Rattus norvegicus 111-119 19729610-5 2009 Supplementation with 17beta-estradiol resulted in a >15x increase in uterine weight and attenuation of atherogenesis in all mice, although HSP27(o/e)apoE(-/-) had 34% less lesion burden compared to apoE(-/-) mice. Estradiol 21-37 heat shock protein 1 Mus musculus 142-147 19523531-7 2009 Metabolic inhibition also induced tyrosine phosphorylation of connexin43 and increased its association with c-Src, both effects being prevented by 17beta-estradiol (200 nM). Estradiol 147-163 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 108-113 20137687-9 2009 Ovariectomy increased BACE1 expression (135.4%, P < 0.01) and decreased NEP expression (40.8%, P < 0.01) and this effect can be partially antagonized by 17beta-estradiol supplementary [with BACE to 103.5% (P < 0.01) and NEP to 88.4% (P < 0.01)]. Estradiol 159-175 beta-secretase 1 Rattus norvegicus 22-27 20137687-9 2009 Ovariectomy increased BACE1 expression (135.4%, P < 0.01) and decreased NEP expression (40.8%, P < 0.01) and this effect can be partially antagonized by 17beta-estradiol supplementary [with BACE to 103.5% (P < 0.01) and NEP to 88.4% (P < 0.01)]. Estradiol 159-175 membrane metallo-endopeptidase Rattus norvegicus 75-78 20137687-9 2009 Ovariectomy increased BACE1 expression (135.4%, P < 0.01) and decreased NEP expression (40.8%, P < 0.01) and this effect can be partially antagonized by 17beta-estradiol supplementary [with BACE to 103.5% (P < 0.01) and NEP to 88.4% (P < 0.01)]. Estradiol 159-175 beta-secretase 1 Rattus norvegicus 22-26 19494250-9 2009 SERPINA14 mRNA was significantly upregulated in glandular endometrial cells in vitro after stimulation with estradiol-17beta and progesterone, but not after interferon-tau treatment. Estradiol 108-124 uterine milk protein Bos taurus 0-9 19616401-0 2009 Low doses of estradiol partly inhibit release of GH in sheep without affecting basal levels. Estradiol 13-22 somatotropin Ovis aries 49-51 19616401-2 2009 This study sought to determine the effects of estradiol on GH-releasing hormone (GRH)-stimulated GH release in sheep. Estradiol 46-55 somatotropin Ovis aries 59-61 19616401-5 2009 The effect of estradiol treatment on GRH-stimulated GH release revealed differences between the control and estradiol-treated animals (P < 0.05). Estradiol 14-23 somatotropin Ovis aries 52-54 19616401-5 2009 The effect of estradiol treatment on GRH-stimulated GH release revealed differences between the control and estradiol-treated animals (P < 0.05). Estradiol 108-117 somatotropin Ovis aries 52-54 19497305-6 2009 17beta-Estradiol reduced Rac1-expression concentration- and time-dependently and decreased basal, as well as AngII-induced Rac1 activity. Estradiol 0-16 Rac family small GTPase 1 Homo sapiens 25-29 19497305-6 2009 17beta-Estradiol reduced Rac1-expression concentration- and time-dependently and decreased basal, as well as AngII-induced Rac1 activity. Estradiol 0-16 Rac family small GTPase 1 Homo sapiens 123-127 19497305-8 2009 In vivo, down-regulation of Rac1 by 17beta-estradiol was observed in human mononuclear cells of women with elevated 17beta-estradiol levels after controlled ovarian hyperstimulation. Estradiol 36-52 Rac family small GTPase 1 Homo sapiens 28-32 19497305-8 2009 In vivo, down-regulation of Rac1 by 17beta-estradiol was observed in human mononuclear cells of women with elevated 17beta-estradiol levels after controlled ovarian hyperstimulation. Estradiol 116-132 Rac family small GTPase 1 Homo sapiens 28-32 19497305-9 2009 In summary, the data show that down-regulation of Rac1-GTPase contributes to the inhibition of angiotensin II-mediated superoxide release by 17beta-estradiol in monocytes. Estradiol 141-157 Rac family small GTPase 1 Homo sapiens 50-54 19420388-1 2009 We have previously shown that 17beta-estradiol (E(2)) increases vascular endothelial growth factor A (Vegfa) gene expression in the rat uterus, resulting in increased microvascular permeability, and that this involves the simultaneous recruitment of hypoxia-inducible factor 1 (HIF1) and estrogen receptor alpha (ESR1) to the Vegfa gene promoter. Estradiol 30-46 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 278-282 19531952-14 2009 CONCLUSIONS: These results suggest that the 17beta-estradiol-meditated improvement in cardiac function following trauma-hemorrhage occurs via Akt-dependent heme oxygenase-1 up-regulation. Estradiol 51-60 heme oxygenase 1 Rattus norvegicus 156-172 19627519-8 2009 The mRNAs for transcription factors c-fos and c-jun, which together form the AP-1 heterodimer, and Ets-1 that modulates the PEA-3 site, were upregulated by relaxin or beta-estradiol plus relaxin. Estradiol 167-181 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 36-41 19627519-8 2009 The mRNAs for transcription factors c-fos and c-jun, which together form the AP-1 heterodimer, and Ets-1 that modulates the PEA-3 site, were upregulated by relaxin or beta-estradiol plus relaxin. Estradiol 167-181 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 46-51 19627519-8 2009 The mRNAs for transcription factors c-fos and c-jun, which together form the AP-1 heterodimer, and Ets-1 that modulates the PEA-3 site, were upregulated by relaxin or beta-estradiol plus relaxin. Estradiol 167-181 ETS variant transcription factor 4 Homo sapiens 124-129 19625529-3 2009 These neurons are the direct targets for the action of estradiol-17beta (E(2)), which acts via the estrogen receptor alpha isoform (ER alpha) to regulate Kiss1 expression. Estradiol 55-71 KiSS-1 metastasis-suppressor Mus musculus 154-159 19596925-0 2009 O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells. Estradiol 69-85 O-6-methylguanine-DNA methyltransferase Homo sapiens 0-38 19596925-3 2009 We questioned whether 17beta-estradiol could modulate the machinery of promoter methylation to cause the gender difference of MGMT hypermethylation in lung cancer. Estradiol 22-38 O-6-methylguanine-DNA methyltransferase Homo sapiens 126-130 19596925-5 2009 RESULTS: Our data showed that 17beta-estradiol, similar to AZA, diminished the MGMT hypermethylation and restored MGMT mRNA expression, which was not observed in the case of TSA. Estradiol 30-46 O-6-methylguanine-DNA methyltransferase Homo sapiens 79-83 19596925-5 2009 RESULTS: Our data showed that 17beta-estradiol, similar to AZA, diminished the MGMT hypermethylation and restored MGMT mRNA expression, which was not observed in the case of TSA. Estradiol 30-46 O-6-methylguanine-DNA methyltransferase Homo sapiens 114-118 19596925-6 2009 Western blotting showed that 17beta-estradiol markedly reduced DNMT1 expression in Ch27 and H1355 cells, but slightly reduced HDAC1 expression. Estradiol 29-45 DNA methyltransferase 1 Homo sapiens 63-68 19596925-8 2009 In addition, ChIP analysis revealed that 17beta-estradiol simultaneously diminished the binding activity of both proteins on the MGMT promoter of both cell lines. Estradiol 41-57 O-6-methylguanine-DNA methyltransferase Homo sapiens 129-133 19596925-9 2009 CONCLUSION: 17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer. Estradiol 12-28 DNA methyltransferase 1 Homo sapiens 39-44 19596925-9 2009 CONCLUSION: 17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer. Estradiol 12-28 O-6-methylguanine-DNA methyltransferase Homo sapiens 105-109 19596925-9 2009 CONCLUSION: 17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer. Estradiol 12-28 O-6-methylguanine-DNA methyltransferase Homo sapiens 182-186 18618240-3 2009 In addition, inducibility of CAR expression by estradiol and tamoxifen was assessed in various breast cancer cell lines. Estradiol 47-56 CXADR Ig-like cell adhesion molecule Homo sapiens 29-32 18618240-7 2009 In the hormone receptor-positive breast cancer cell line T47-D expression of hCAR and its soluble isoforms was increased by treatment with estradiol and tamoxifen. Estradiol 139-148 CXADR Ig-like cell adhesion molecule Homo sapiens 77-81 18618240-9 2009 Furthermore, enhancement of hCAR expression was significantly greater when cells were treated with the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) than when treated with estradiol or tamoxifen. Estradiol 184-193 CXADR Ig-like cell adhesion molecule Homo sapiens 28-32 19299459-5 2009 Replacement of 17-beta-estradiol (E2) in P15-ovariectomized mice from P15-30 or P22-30 resulted in a complete restoration of kisspeptin peptide expression in the RP3V (P < 0.01). Estradiol 15-32 KiSS-1 metastasis-suppressor Mus musculus 125-135 19573286-8 2009 Clinical studies on the p.N680S polymorphism of the FSHR gene have demonstrated the homozygous Ser/Ser variant to be less sensitive to endogenous or exogenous FSH in terms of oestradiol production. Estradiol 175-185 follicle stimulating hormone receptor Homo sapiens 52-56 19428444-5 2009 This regimen of estradiol treatment involves classical intracellular estrogen receptors, transactivation of IGF-1 receptors and stimulation of the ERK/MAPK signaling pathway, which in turn maintains CREB activity in the ischemic CA1. Estradiol 16-25 cAMP responsive element binding protein 1 Homo sapiens 199-203 19428444-5 2009 This regimen of estradiol treatment involves classical intracellular estrogen receptors, transactivation of IGF-1 receptors and stimulation of the ERK/MAPK signaling pathway, which in turn maintains CREB activity in the ischemic CA1. Estradiol 16-25 carbonic anhydrase 1 Homo sapiens 229-232 19527530-10 2009 TESTING THE HYPOTHESIS: We propose to test our hypothesis on ovariectomized rats, by stereotaxically injecting 17beta-estradiol and/or an NTPDase-inhibitor into the arcuate nucleus and determine the consequential levels of blood LH, mitochondrial respiration rates from arcuate nucleus synaptosomal preparations, NTPDase3-expression from arcuate nucleus tissue samples, all compared to sham and intact controls. Estradiol 111-127 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 313-321 19130215-0 2009 17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway. Estradiol 0-16 transthyretin Mus musculus 25-38 19186013-1 2009 BACKGROUND: Vascular endothelial growth factor (VEGF) is essential for embryonic lung development and has been shown to be regulated by estradiol (E2) and progesterone (P). Estradiol 136-145 vascular endothelial growth factor A Canis lupus familiaris 12-46 19186013-1 2009 BACKGROUND: Vascular endothelial growth factor (VEGF) is essential for embryonic lung development and has been shown to be regulated by estradiol (E2) and progesterone (P). Estradiol 136-145 vascular endothelial growth factor A Canis lupus familiaris 48-52 19173292-5 2009 Forced expression of HOPX resulted in a partial block in cell proliferation, in vivo tumorigenicity and c-fos gene expression in HEC and MCF7 cells in response to 17beta-estradiol (E(2)) stimulation. Estradiol 163-179 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 104-109 19115413-9 2009 Estradiol treatment increased the dopamine transporter in subregions of the intact caudate and putamen compared with the intact striata of vehicle-treated monkeys, but not in the lesioned striata. Estradiol 0-9 solute carrier family 6 member 3 Homo sapiens 34-54 19428988-12 2009 These studies characterize a direct inhibitory effect of estradiol on GnRH in GnRH neurons, and a direct stimulatory effect of estradiol on PR gene expression. Estradiol 127-136 progesterone receptor Mus musculus 140-142 19281799-0 2009 Divergent effects of estradiol and the estrogen receptor-alpha agonist PPT on eating and activation of PVN CRH neurons in ovariectomized rats and mice. Estradiol 21-30 corticotropin releasing hormone Mus musculus 107-110 19302193-8 2009 No effect of ageing was detected for immunofluorescent NR1 or NR2b alone, whereas the NR2b fraction volume increased in the oestradiol plus vehicle group. Estradiol 124-134 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 86-90 19435816-6 2009 We also found that estradiol (E(2)) treatment produced a 3-fold increase in endogenous Wip1 mRNA and protein expression in MCF7 cells. Estradiol 19-28 protein phosphatase, Mg2+/Mn2+ dependent 1D Homo sapiens 87-91 19435816-6 2009 We also found that estradiol (E(2)) treatment produced a 3-fold increase in endogenous Wip1 mRNA and protein expression in MCF7 cells. Estradiol 30-34 protein phosphatase, Mg2+/Mn2+ dependent 1D Homo sapiens 87-91 19298887-11 2009 It could be demonstrated that the combination of trenbolone acetate plus estradiol significantly influences mRNA expression of the steroid receptors (ER-alpha and GR-alpha), the apoptosis regulator Fas, the proinflammatory interleukins IL-1alpha, IL-1beta and IL-6 and of MHCII, CK, MTPN, RBM5 and Actin-beta. Estradiol 73-82 nuclear receptor subfamily 3 group C member 1 Bos taurus 163-171 19022884-10 2009 BMP-2, BMP-4, and activin increased FSH-induced estradiol production, which was enhanced in the presence of oocytes. Estradiol 48-57 bone morphogenetic protein 4 Rattus norvegicus 7-12 19150483-6 2009 SF-1 is the key factor determining that an endometriotic cell will respond to PGE(2) by increased estradiol formation. Estradiol 98-107 splicing factor 1 Homo sapiens 0-4 19150393-6 2009 OVX rats exposed to estradiol for 24 h showed increased DYN-ir in the DG and CA3, while those with 72 h estradiol exposure showed increases only in the DG. Estradiol 20-29 carbonic anhydrase 3 Rattus norvegicus 77-80 19302141-2 2009 We here demonstrate that treatment with 17beta-oestradiol (E(2)) in C57BL/6 mice boosted the expression of programmed death 1 (PD-1), a negative regulator of immune responses, in the CD4(+) FoxP3(+) regulatory T (Treg) cell compartment in a dose-dependent manner that correlated with the efficiency of EAE protection. Estradiol 40-57 CD4 antigen Mus musculus 183-186 19111554-5 2009 Fluorometric measurements with the pHi-sensitive dye BCECF demonstrated that at 1 pM 17beta-estradiol increased pHi (+0.05 pH units in females and +0.12 pH units in males, P<0.05) by a rapid non-genomic mechanism that was blocked by the sodium-hydrogen exchange isoform 1 (NHE-1) specific inhibitor AVE-4890 (AVE, 5 microM). Estradiol 85-101 solute carrier family 9 member A1 Rattus norvegicus 276-281 19111554-6 2009 Treatment with 1 pM 17beta-estradiol for 24 h increased cell size (females: 20%, P<0.05; males: 29%, P<0.05) and ANP expression (females: 414%, P<0.05; males: 497%, P<0.05) in a NHE-1-, and ERK1/2 MAPK-dependent manner. Estradiol 20-36 solute carrier family 9 member A1 Rattus norvegicus 190-195 19207808-3 2009 The results from a series of studies further suggest that the rapid action of E(2) in primate LHRH neurones appears to be mediated by GPR30. Estradiol 78-82 G protein-coupled estrogen receptor 1 Homo sapiens 134-139 19190350-1 2009 17beta-Hydroxysteroid dehydrogenase type 12 (17beta-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). Estradiol 171-180 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 0-43 19190350-1 2009 17beta-Hydroxysteroid dehydrogenase type 12 (17beta-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). Estradiol 171-180 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 45-57 18845628-0 2009 Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol. Estradiol 102-111 stanniocalcin 1 Sus scrofa 0-15 19395996-0 2009 Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells. Estradiol 0-9 G protein-coupled estrogen receptor 1 Homo sapiens 84-113 19395996-3 2009 G-protein-coupled receptor 30 (GPR30) is a newly identified membrane estrogen receptor (ER).The objective of this study was to explore the effects of 17beta-estradiol (E(2)) on uPAR expression and cell migration in ovarian cancer cells and further to identify the ER involved.We used 7 ovarian cancer cell lines, cell migration assay, cellular binding of (125)I-uPA, cellular degradation of (125)I-uPA/PAI-1 complex, enzyme-linked immunosorbent assay for uPAR, solid-phase enzyme immunoassay for ERalpha, and quantitative polymerase chain reaction. Estradiol 150-166 G protein-coupled estrogen receptor 1 Homo sapiens 0-29 19395996-3 2009 G-protein-coupled receptor 30 (GPR30) is a newly identified membrane estrogen receptor (ER).The objective of this study was to explore the effects of 17beta-estradiol (E(2)) on uPAR expression and cell migration in ovarian cancer cells and further to identify the ER involved.We used 7 ovarian cancer cell lines, cell migration assay, cellular binding of (125)I-uPA, cellular degradation of (125)I-uPA/PAI-1 complex, enzyme-linked immunosorbent assay for uPAR, solid-phase enzyme immunoassay for ERalpha, and quantitative polymerase chain reaction. Estradiol 150-166 G protein-coupled estrogen receptor 1 Homo sapiens 31-36 19016568-5 2009 We found that a rapid increase in BRCA2 S3291 phosphorylation occurs following 17-beta-oestradiol (E2) treatment. Estradiol 79-97 BRCA2 DNA repair associated Homo sapiens 34-39 19016568-5 2009 We found that a rapid increase in BRCA2 S3291 phosphorylation occurs following 17-beta-oestradiol (E2) treatment. Estradiol 99-101 BRCA2 DNA repair associated Homo sapiens 34-39 19063890-5 2009 Acting in a similar manner, gonadal steroids (estradiol and testosterone) stimulated both fshb and lhb, but had no effect on gh. Estradiol 46-55 follicle stimulating hormone subunit beta Danio rerio 90-94 19671994-8 2009 Furthermore, RBP4 was positively associated with 17beta-estradiol in only diabetic postmenopausal women. Estradiol 49-65 retinol binding protein 4 Homo sapiens 13-17 18673094-7 2009 CONCLUSION: Elevated serum adenosine deaminase in patients with hyperemesis gravidarum may relate to high levels of E2 and progesterone. Estradiol 116-118 adenosine deaminase Homo sapiens 27-46 24459527-9 2008 TRPM6 is regulated at the transcriptional level by acid-base status, 17beta-estradiol, and both FK506 and cyclosporine. Estradiol 69-85 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 19079715-2 2008 Recent investigations have demonstrated that the orphan G-protein-coupled receptor 30 (GPR30), which is structurally unrelated to the ER, mediates rapid actions of 17beta-estradiol and environmental estrogens. Estradiol 164-180 G protein-coupled estrogen receptor 1 Homo sapiens 56-85 19079715-2 2008 Recent investigations have demonstrated that the orphan G-protein-coupled receptor 30 (GPR30), which is structurally unrelated to the ER, mediates rapid actions of 17beta-estradiol and environmental estrogens. Estradiol 164-180 G protein-coupled estrogen receptor 1 Homo sapiens 87-92 18932123-3 2008 The effect of 17- beta-estradiol and 1,25dihydroxyvitamin D3 on the OPG/RANKL system is not known during the different states of cellular maturation. Estradiol 14-32 TNF superfamily member 11 Homo sapiens 72-77 18972403-1 2008 UNLABELLED: The endogenous estradiol metabolite estradiol 17beta-D-glucuronide (E(2)17G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt export pump (Bsep, Abcc11) and multidrug resistance-associated protein 2 (Mrp2, Abcc2) and their associated loss of function. Estradiol 27-36 ATP binding cassette subfamily C member 2 Rattus norvegicus 230-271 18972403-1 2008 UNLABELLED: The endogenous estradiol metabolite estradiol 17beta-D-glucuronide (E(2)17G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt export pump (Bsep, Abcc11) and multidrug resistance-associated protein 2 (Mrp2, Abcc2) and their associated loss of function. Estradiol 27-36 ATP binding cassette subfamily C member 2 Rattus norvegicus 273-277 18972403-1 2008 UNLABELLED: The endogenous estradiol metabolite estradiol 17beta-D-glucuronide (E(2)17G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt export pump (Bsep, Abcc11) and multidrug resistance-associated protein 2 (Mrp2, Abcc2) and their associated loss of function. Estradiol 27-36 ATP binding cassette subfamily C member 2 Rattus norvegicus 279-284 18768737-0 2008 17-Beta-estradiol inhibits transforming growth factor-beta signaling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30. Estradiol 0-17 G protein-coupled estrogen receptor 1 Homo sapiens 173-202 18768737-6 2008 Silencing of GPR30 in MCF-7 cells completely reduced the ability of 17-beta-estradiol (E2) to inhibit the TGF-beta pathway. Estradiol 68-85 G protein-coupled estrogen receptor 1 Homo sapiens 13-18 18818282-2 2008 Although CART is not expressed in mouse ovaries, we have previously established CART as a novel intracellular regulator of estradiol production in bovine granulosa cells. Estradiol 123-132 CART prepropeptide Mus musculus 9-13 18818282-2 2008 Although CART is not expressed in mouse ovaries, we have previously established CART as a novel intracellular regulator of estradiol production in bovine granulosa cells. Estradiol 123-132 CART prepropeptide Mus musculus 80-84 18083251-11 2008 These results strongly suggest that estradiol protects rats from the development of hypertension and has a protective effect on the endothelium by increasing NO and ANP levels while decreasing renin activity. Estradiol 36-45 natriuretic peptide A Rattus norvegicus 165-168 18395250-0 2008 Rapid effects of 17beta-estradiol on epithelial TRPV6 Ca2+ channel in human T84 colonic cells. Estradiol 17-33 transient receptor potential cation channel subfamily V member 6 Homo sapiens 48-53 18395250-3 2008 The role of steroid hormone 17beta-estradiol (E(2)), in [Ca(2+)](i) regulation involving TRPV6 has been only limited at the protein expression levels in over-expressing heterologous systems. Estradiol 28-44 transient receptor potential cation channel subfamily V member 6 Homo sapiens 89-94 18395250-7 2008 TRPV6 channels in T84 cells contribute to the Ca(2+) entry/signalling pathway that is sensitive to 17beta-estradiol. Estradiol 99-115 transient receptor potential cation channel subfamily V member 6 Homo sapiens 0-5 18753261-0 2008 Estradiol replacement enhances sleep deprivation-induced c-Fos immunoreactivity in forebrain arousal regions of ovariectomized rats. Estradiol 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 57-62 18753261-1 2008 To understand how female sex hormones influence homeostatic mechanisms of sleep, we studied the effects of estradiol (E(2)) replacement on c-Fos immunoreactivity in sleep/wake-regulatory brain areas after sleep deprivation (SD) in ovariectomized rats. Estradiol 118-123 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 139-144 18650055-0 2008 Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17beta-stimulated IGF-I mRNA expression in bovine satellite cell cultures. Estradiol 59-68 IGFI Bos taurus 87-92 18650055-2 2008 Estradiol-17beta (E2) and trenbolone acetate (TBA) (a synthetic testosterone analog) increased IGF-I mRNA expression in bovine muscle satellite cell (BSC) cultures. Estradiol 0-16 IGFI Bos taurus 95-100 18650055-2 2008 Estradiol-17beta (E2) and trenbolone acetate (TBA) (a synthetic testosterone analog) increased IGF-I mRNA expression in bovine muscle satellite cell (BSC) cultures. Estradiol 18-20 IGFI Bos taurus 95-100 18632874-7 2008 For some cancer-associated genes, including Klk1, Ihh, Cdc45l, and Cdca8, administration of MPP or raloxifene with estradiol resulted in greater expression than estradiol alone (P<0.05). Estradiol 115-124 kallikrein 1 Mus musculus 44-48 18632874-7 2008 For some cancer-associated genes, including Klk1, Ihh, Cdc45l, and Cdca8, administration of MPP or raloxifene with estradiol resulted in greater expression than estradiol alone (P<0.05). Estradiol 115-124 Indian hedgehog Mus musculus 50-53 18632874-7 2008 For some cancer-associated genes, including Klk1, Ihh, Cdc45l, and Cdca8, administration of MPP or raloxifene with estradiol resulted in greater expression than estradiol alone (P<0.05). Estradiol 115-124 cell division cycle associated 8 Mus musculus 67-72 18499749-7 2008 Estradiol replacement in VEGF Trap-treated marmosets resulted in only a small increase in endothelial cell proliferation that remained significantly below control values. Estradiol 0-9 vascular endothelial growth factor A Callithrix jacchus 25-29 18603607-8 2008 Our data support that physiological differences in proteins involved in cholesterol balance are present between the sexes and, in particular, 3-hydroxy 3-methylglutaryl coenzyme A reductase shows lower activity and expression in female and 17-beta-estradiol-treated male rats than in adult untreated male. Estradiol 240-257 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 142-189 18556508-2 2008 In the present study, lineage-negative (Lin(-))/stem cell antigen-1-positive (Sca-1+)/c-Kit+ (LSK) cell content was significantly elevated in bone marrow (BM) of TIS21-knockout (TIS21(-/-)) female mice, suggesting 17beta-estradiol (E(2))-regulated progenitor expansion. Estradiol 214-230 lymphocyte antigen 6 complex, locus A Mus musculus 78-85 18598848-5 2008 Pre-incubation of estradiol prior to CoCl(2) treatment attenuated CoCl(2)-mediated the reactive oxygen species (ROS) production and limited the activities of the caspase cascades, such as caspase-8, -9 and -3. Estradiol 18-27 caspase 8 Rattus norvegicus 162-169 18598848-5 2008 Pre-incubation of estradiol prior to CoCl(2) treatment attenuated CoCl(2)-mediated the reactive oxygen species (ROS) production and limited the activities of the caspase cascades, such as caspase-8, -9 and -3. Estradiol 18-27 caspase 8 Rattus norvegicus 188-208 18541362-8 2008 The enhancement of LTD by 1-10nM estradiol occurs within 1 h. The density of spine is increased in CA1 pyramidal neurons within 2h after application of estradiol. Estradiol 33-42 carbonic anhydrase 1 Homo sapiens 99-102 18467441-3 2008 Using as a model system SkBr3 and BT20 breast cancer cells lacking the classical ER, the regulation of GPR30 expression by 17beta-estradiol, the selective GPR30 ligand G-1, IGF-I, and epidermal growth factor (EGF) was evaluated. Estradiol 123-139 G protein-coupled estrogen receptor 1 Homo sapiens 103-108 18213625-5 2008 The results support the hypothesis that the A(-656) allele contributes to the development of MDD in women by selectively altering the activity of the CREB1 promoter in glial cells exposed to 17 beta-estradiol. Estradiol 194-208 cAMP responsive element binding protein 1 Homo sapiens 150-155 18456672-6 2008 RESULTS: Our results showed that the combination of 17beta-estradiol and TCDD increased the secretion of RANTES and MIP-1alpha, promoted the invasiveness of ESC and increased the expression of MMP-2 and MMP-9 in ESC. Estradiol 52-68 matrix metallopeptidase 9 Homo sapiens 203-208 18247370-7 2008 Taken together, our findings support a model in which ERalpha/AP-1 complexes modulate F promoter activity under conditions of 17-beta-estradiol stimulation. Estradiol 126-143 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 62-66 18590437-1 2008 OBJECT: The authors previously demonstrated that 17beta-estradiol benzoate (E2) treatment prevents subarachnoid hemorrhage (SAH)-induced cerebral vasospasm and preserves endothelial nitric oxide synthase (eNOS) in male rats. Estradiol 76-78 nitric oxide synthase 3 Rattus norvegicus 170-203 18590437-1 2008 OBJECT: The authors previously demonstrated that 17beta-estradiol benzoate (E2) treatment prevents subarachnoid hemorrhage (SAH)-induced cerebral vasospasm and preserves endothelial nitric oxide synthase (eNOS) in male rats. Estradiol 76-78 nitric oxide synthase 3 Rattus norvegicus 205-209 18676106-2 2008 METHODS: ICAM-1 expression was determined by immunofluorescence in HUVEC monolayers treated with LDL or oxLDL and 17beta-estradiol, progesterone or beta-sitosterol. Estradiol 114-130 intercellular adhesion molecule 1 Homo sapiens 9-15 18676106-6 2008 RESULTS: ICAM-1 expression was inhibited by beta-sitosterol alone, when combined with 17beta-estradiol or progesterone, or with both hormones. Estradiol 86-102 intercellular adhesion molecule 1 Homo sapiens 9-15 18469803-6 2008 Here we show that pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia-like phenotype resulting from an absence of 2-methoxyoestradiol (2-ME), a natural metabolite of oestradiol that is elevated during the third trimester of normal human pregnancy. Estradiol 155-165 catechol-O-methyltransferase Mus musculus 45-73 18469803-6 2008 Here we show that pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia-like phenotype resulting from an absence of 2-methoxyoestradiol (2-ME), a natural metabolite of oestradiol that is elevated during the third trimester of normal human pregnancy. Estradiol 155-165 catechol-O-methyltransferase Mus musculus 75-79 18408136-0 2008 p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage. Estradiol 53-69 nitric oxide synthase 3 Rattus norvegicus 19-23 18434445-11 2008 Administration of SB-203580 with E(2) abolished the E(2)-mediated restoration of the above parameters as well as the increase in intestinal HO-1 expression following trauma-hemorrhage. Estradiol 33-37 heme oxygenase 1 Rattus norvegicus 140-144 18520045-5 2008 However the yeast two-hybrid assay showed that TS did not bind estrogen receptors alpha and beta and immunohistochemical staining revealed that 17beta-estradiol stimulated the protein expression of estrogen receptor alpha, progesterone receptor, c-fos and c-jun in the uterus, whereas TS did not. Estradiol 144-160 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 246-251 18520045-5 2008 However the yeast two-hybrid assay showed that TS did not bind estrogen receptors alpha and beta and immunohistochemical staining revealed that 17beta-estradiol stimulated the protein expression of estrogen receptor alpha, progesterone receptor, c-fos and c-jun in the uterus, whereas TS did not. Estradiol 144-160 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 256-261 18378096-6 2008 Further analysis demonstrated that the binding capacity of platelet PBR was closely related to estradiol plasma level in all subjects. Estradiol 95-104 translocator protein Homo sapiens 68-71 18493596-6 2008 Moesin activation by estradiol depends on the interaction of ER alpha with the G protein G alpha(13), which results in the recruitment of the small GTPase RhoA and in the subsequent activation of its downstream effector Rho-associated kinase-2 (ROCK-2). Estradiol 21-30 G protein subunit alpha 13 Homo sapiens 89-100 18302931-4 2008 In this study, using beta-estradiol inducible stable cell lines we show that the point mutation of phosphorylation site S248 in C/EBP disrupts the CD11b and GCSFr expression and subsequently reduces the differentiation of leukemic K562 cells. Estradiol 21-35 integrin subunit alpha M Homo sapiens 147-152 18337202-1 2008 UNLABELLED: Using osteoprotegerin (OPG)-knockout mice, we demonstrated that in vivo the effects of both genistein and 17beta-estradiol (E2) on bone metabolism were completely abolished. Estradiol 118-134 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 18-33 18337202-1 2008 UNLABELLED: Using osteoprotegerin (OPG)-knockout mice, we demonstrated that in vivo the effects of both genistein and 17beta-estradiol (E2) on bone metabolism were completely abolished. Estradiol 118-134 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 35-38 18219319-7 2008 Here we report the crystal structure of the MDM2/MDMX RING domain heterodimer and map residues required for functional interaction with the E2 (UbcH5b). Estradiol 140-142 MDM2 proto-oncogene Homo sapiens 44-48 18296494-0 2008 Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17beta-oestradiol regulation of renal pathology in renal wrap hypertension in rats. Estradiol 64-81 angiotensin I converting enzyme 2 Rattus norvegicus 8-39 18188139-2 2008 In this study we examined the effect of 17beta-estradiol (E2) alone and in combination with two progestins on the endothelin-1 (ET-1) system in coronary arteries. Estradiol 40-56 endothelin-1 Oryctolagus cuniculus 114-126 18304583-9 2008 Our primary hypothesis is that estradiol stimulates sodium pump activity/expression in VSMC via PI3K/cPLA(2)/p42/44(MAPK) dependent mechanism and, that impaired estradiol-stimulated sodium pump activity/expression in hypertensive rodent models (i.e. SHR), Ang II-mediated vascular impairment of estradiol is related to a decrease ability of estradiol to stimulate the PI3K/cPLA(2)/p42/44(MAPK) signaling pathways. Estradiol 31-40 angiogenin Rattus norvegicus 256-259 18304583-9 2008 Our primary hypothesis is that estradiol stimulates sodium pump activity/expression in VSMC via PI3K/cPLA(2)/p42/44(MAPK) dependent mechanism and, that impaired estradiol-stimulated sodium pump activity/expression in hypertensive rodent models (i.e. SHR), Ang II-mediated vascular impairment of estradiol is related to a decrease ability of estradiol to stimulate the PI3K/cPLA(2)/p42/44(MAPK) signaling pathways. Estradiol 161-170 angiogenin Rattus norvegicus 256-259 18304583-9 2008 Our primary hypothesis is that estradiol stimulates sodium pump activity/expression in VSMC via PI3K/cPLA(2)/p42/44(MAPK) dependent mechanism and, that impaired estradiol-stimulated sodium pump activity/expression in hypertensive rodent models (i.e. SHR), Ang II-mediated vascular impairment of estradiol is related to a decrease ability of estradiol to stimulate the PI3K/cPLA(2)/p42/44(MAPK) signaling pathways. Estradiol 161-170 angiogenin Rattus norvegicus 256-259 18304583-9 2008 Our primary hypothesis is that estradiol stimulates sodium pump activity/expression in VSMC via PI3K/cPLA(2)/p42/44(MAPK) dependent mechanism and, that impaired estradiol-stimulated sodium pump activity/expression in hypertensive rodent models (i.e. SHR), Ang II-mediated vascular impairment of estradiol is related to a decrease ability of estradiol to stimulate the PI3K/cPLA(2)/p42/44(MAPK) signaling pathways. Estradiol 161-170 angiogenin Rattus norvegicus 256-259 18316064-9 2008 Moreover, 17beta-estradiol-treated rats showed reactive astrocytes as soon as 3 days following SCI, with increased GFAP expression, smaller lesion areas and more limited diffusion of CD68-positive cells after 1 week post-injury compared to controls. Estradiol 10-26 glial fibrillary acidic protein Rattus norvegicus 115-119 16901928-14 2006 In adult male killifish, ERR expression did not significantly change following estradiol injection, but showed a trend toward a slight induction (three- to five-fold) of ERRalpha expression in heart. Estradiol 79-88 solute carrier family 7 member 1 Homo sapiens 25-28 16901928-15 2006 In a second, more targeted experiment, expression of ERRalpha in adult female killifish was downregulated 2.5-fold in the heart following estradiol injection. Estradiol 138-147 steroid hormone receptor ERR1 Fundulus heteroclitus 53-61 16886669-3 2006 By applying quantitative RT-PCR and HPLC it was observed that in colon-(Caco-2) and breast-(MCF-7) derived cells, 17beta-estradiol and genistein induced CYP27B1 but reduced CYP24 activity, while equol was inactive. Estradiol 114-130 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 173-178 16574784-0 2006 Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Estradiol 71-87 kinase insert domain receptor Homo sapiens 0-45 16574784-1 2006 Vascular endothelial growth factor receptor-2 kinase insert domain receptor (VEGFR2/KDR) is critical for angiogenesis, and VEGFR2 mRNA and protein are expressed in ZR-75 breast cancer cells and induced by 17beta-estradiol (E2). Estradiol 205-221 kinase insert domain receptor Homo sapiens 0-45 16574784-1 2006 Vascular endothelial growth factor receptor-2 kinase insert domain receptor (VEGFR2/KDR) is critical for angiogenesis, and VEGFR2 mRNA and protein are expressed in ZR-75 breast cancer cells and induced by 17beta-estradiol (E2). Estradiol 205-221 kinase insert domain receptor Homo sapiens 77-83 16574784-1 2006 Vascular endothelial growth factor receptor-2 kinase insert domain receptor (VEGFR2/KDR) is critical for angiogenesis, and VEGFR2 mRNA and protein are expressed in ZR-75 breast cancer cells and induced by 17beta-estradiol (E2). Estradiol 205-221 kinase insert domain receptor Homo sapiens 84-87 16574784-1 2006 Vascular endothelial growth factor receptor-2 kinase insert domain receptor (VEGFR2/KDR) is critical for angiogenesis, and VEGFR2 mRNA and protein are expressed in ZR-75 breast cancer cells and induced by 17beta-estradiol (E2). Estradiol 205-221 kinase insert domain receptor Homo sapiens 123-129 16541422-4 2006 RESULTS: mRNAs of both enzymes were detected in all prostate cancer cell lines examined, and the synthesis of estrone (E(1)) and estradiol (E(2)) was also confirmed in these cell lines. Estradiol 129-138 cystatin 12, pseudogene Homo sapiens 140-144 16621521-7 2006 Furthermore estradiol-induced apoptosis shown by with nuclear condensation and Bax/Bcl2 ratio. Estradiol 12-21 BCL2-associated X protein Mus musculus 79-82 16621521-10 2006 However, increased caspase-3 activity by estradiol was observed in the presence of caspase-9 inhibitor, indicating the preferential involvement of caspase-8 pathway. Estradiol 41-50 caspase 3 Mus musculus 19-28 16621521-12 2006 However, estradiol enhanced caspase-3 activity in Fas-induced apoptosis on mature osteoclasts, suggesting that this might interact with the Fas-signaling pathway. Estradiol 9-18 caspase 3 Mus musculus 28-37 17142999-10 2006 For example, 1 nM 17beta-estradiol rapidly enhanced the long-term depression (LTD) not only in CA1 but also in CA3 and dentate gyrus. Estradiol 18-34 carbonic anhydrase 1 Homo sapiens 95-98 17142999-11 2006 The density of thin spines was selectively increased within 2 h upon application of 1 nM estradiol in CA1 pyramidal neurons. Estradiol 89-98 carbonic anhydrase 1 Homo sapiens 102-105 17142999-12 2006 Only ERalpha agonist propyl-pyrazole-trinyl-phenol induced the same enhancing effect as estradiol on both LTD and spinogenesis in the CA1. Estradiol 88-97 carbonic anhydrase 1 Homo sapiens 134-137 16404153-9 2005 These results suggest that the altered expression of Hsps (especially Hsp56 and Hsp60) by E2 metabolites such as E2, 16a-OHE1 and 2-ME could be closely linked to their mitogenic action. Estradiol 90-92 heat shock protein family D (Hsp60) member 1 Homo sapiens 80-85 16242668-3 2005 Here we demonstrated the rapid effect of estradiol on the density of thorns of thorny excrescences, by imaging Lucifer Yellow-injected CA3 neurons in adult male rat hippocampal slices. Estradiol 41-50 carbonic anhydrase 3 Rattus norvegicus 135-138 16326838-7 2005 Abundance of COX-2 transcripts in thecal tissue incubated with forskolin depended on the progesterone/17beta-oestradiol ratio of the follicle fluid, i.e. the previous microenvironment in vivo. Estradiol 102-119 prostaglandin-endoperoxide synthase 2 Bos taurus 13-18 16270204-6 2005 Quantitative Reverse Transcription (QRT)-PCR data showed that GA down-regulated genes AtGA3ox1, AtGA20ox1 and SCARECROW-LIKE3 (SCL3) were up-regulated and the GA up-regulated genes AtGA2ox1 and AtExp1 were down-regulated in estradiol-treated leaves of inducible PcGA2ox1 overexpressors; neighbouring non-treated leaves showing no significant changes. Estradiol 224-233 scarecrow-like 3 Arabidopsis thaliana 127-131 16272305-2 2005 The mRNA expression and secretion of human beta-defensin-2 and CXCL8 by uterine epithelial cells was examined following stimulation with IL-1beta in the presence of estradiol or progesterone. Estradiol 165-174 defensin beta 4B Homo sapiens 43-58 16272305-3 2005 Estradiol inhibited the IL-1beta-mediated mRNA expression and secretion of human beta-defensin-2 and CXCL8 by uterine epithelial cells while progesterone had no effect. Estradiol 0-9 defensin beta 4B Homo sapiens 81-96 16234819-8 2005 Moreover, human umbilical vein endothelial cells (HUVEC) incubated with supernatants from oestradiol-treated MCF-7 cells exhibited higher VEGFR-2 levels than controls. Estradiol 90-100 kinase insert domain receptor Homo sapiens 138-145 16234819-10 2005 Our results suggest that tamoxifen and oestradiol exert dual effects on the angiogenic environment in breast cancer by regulating cancer cell-secreted angiogenic ligands such as VEGF and sVEGFR-1 and by affecting VEGFR-2 expression of endothelial cells. Estradiol 39-49 kinase insert domain receptor Homo sapiens 213-220 16269913-2 2005 This study examined whether ethanol exposure and/or ethanol withdrawal (EW) alter the levels of PA in a manner that is protected by 17beta-estradiol (E2). Estradiol 132-148 parvalbumin Rattus norvegicus 96-98 15961530-0 2005 Chronic estradiol and progesterone treatment in conscious dogs: effects on insulin sensitivity and response to hypoglycemia. Estradiol 8-17 insulin Canis lupus familiaris 75-82 15961530-1 2005 We evaluated the effect of chronic (3 wk) subcutaneous treatment with progesterone and estradiol (PE; producing serum levels observed in the 3rd trimester of pregnancy) or placebo (C) on hepatic and whole body insulin sensitivity and response to hypoglycemia in conscious, overnight-fasted nonpregnant female dogs, using tracer and arteriovenous difference techniques. Estradiol 87-96 insulin Canis lupus familiaris 210-217 15961530-10 2005 Chronic progesterone and estradiol exposure caused whole body (primarily skeletal muscle) insulin resistance and enhanced the liver"s response to hypoglycemia without altering counterregulatory hormone concentrations. Estradiol 25-34 insulin Canis lupus familiaris 90-97 16085421-7 2005 Using 17beta-estradiol as a control, the ability to observe specific ligand binding is shown for both high- and low-affinity RXRalpha agonists. Estradiol 6-22 retinoid X receptor alpha Homo sapiens 125-133 16254005-3 2005 We confirmed the expression of IL-13 and IL-15 in these cells and further demonstrated that 17beta estradiol (E2), medroxyprogesterone acetate (MPA) and their combination differentially regulated their mRNA expression and protein production in a time- and cell-specific manner (P < 0.05). Estradiol 92-108 interleukin 15 Homo sapiens 41-46 15919741-8 2005 Double-label in situ hybridization revealed that virtually all KiSS-1-expressing neurons in the Arc and AVPV coexpress ERalpha, suggesting that the effects of E2 are mediated directly through KiSS-1 neurons. Estradiol 159-161 KiSS-1 metastasis-suppressor Mus musculus 63-69 15919741-8 2005 Double-label in situ hybridization revealed that virtually all KiSS-1-expressing neurons in the Arc and AVPV coexpress ERalpha, suggesting that the effects of E2 are mediated directly through KiSS-1 neurons. Estradiol 159-161 KiSS-1 metastasis-suppressor Mus musculus 192-198 16154043-7 2005 RESULTS: Incubation with progesterone or estradiol resulted in a significant upregulation of IL-10 production by iDC and mDC. Estradiol 41-50 interleukin 10 Homo sapiens 93-98 16154043-8 2005 Combinations of progesterone and betaHCG or estradiol respectively induced a significant decrease in production of IL-18 by mDC. Estradiol 44-53 interleukin 18 Homo sapiens 115-120 16133120-10 2005 Co-incubation of IGF-1 with 1 nM oestradiol decreased both PKC isoforms and activated ERK1/2 levels, suggesting that oestradiol would exert its antiproliferative effect by acting on the signalling pathway of IGF-1. Estradiol 33-43 protein kinase C, alpha Rattus norvegicus 59-62 16133120-10 2005 Co-incubation of IGF-1 with 1 nM oestradiol decreased both PKC isoforms and activated ERK1/2 levels, suggesting that oestradiol would exert its antiproliferative effect by acting on the signalling pathway of IGF-1. Estradiol 117-127 protein kinase C, alpha Rattus norvegicus 59-62 16088033-2 2005 In this study, we examine the localization and regulation of the PCI gene and protein expression in testes and freshly isolated Sertoli cells from control rats, rats treated with luteinizing hormone-suppressive testosterone/estradiol (TE)-containing Silastic capsules for 7, 14, 28, and 56 days, and rats treated with TE for 56 days, followed by high levels of testosterone for 7 or 14 days. Estradiol 224-233 serpin family A member 5 Rattus norvegicus 65-68 16125073-13 2005 But aortic explants from male rats pretreated with 17-beta-estradiol had 60% less MMP-9 activity than explants from male controls (p=0.03). Estradiol 51-68 matrix metallopeptidase 9 Rattus norvegicus 82-87 16093915-9 2005 Interestingly, reverse transcriptase-PCR analysis demonstrated that 17beta-estradiol dose-dependently increased the catalytic subunit, telomerase reverse transcriptase (TERT) - an effect that was significantly inhibited by pharmacological phosphatidylinositol 3-kinase (PI3-K) blockers (either wortmannin or LY294002). Estradiol 68-84 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Homo sapiens 239-268 16011487-14 2005 A DAT and VMAT2 specific binding decrease after MPTP in the striatum and substantia nigra, as well as a decrease of substantia nigra VMAT2 mRNA, was observed and could be prevented by oestradiol. Estradiol 184-194 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 10-15 16011487-14 2005 A DAT and VMAT2 specific binding decrease after MPTP in the striatum and substantia nigra, as well as a decrease of substantia nigra VMAT2 mRNA, was observed and could be prevented by oestradiol. Estradiol 184-194 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 133-138 15964511-8 2005 Furthermore, immunohistochemistry results revealed that the abnormal upregulation of the apoptotic related factor such as Bax, Caspase-3, and (Par-4) greatly reduced expression after melatonin or 17beta-estradiol supplement action. Estradiol 196-212 pro-apoptotic WT1 regulator Rattus norvegicus 143-148 16138832-4 2005 The hUtE showed a similar proliferative response and increase in progesterone receptors (PR) in response to 17beta-estradiol (E2) in association with either human or mUtS, as TRs. Estradiol 108-124 solute carrier family 14 member 1 (Kidd blood group) Homo sapiens 4-8 16102288-6 2005 Beta1-AR was expressed in both control and experimental plates; beta2-AR was expressed only in plates incubated with embryonic culture media of embryos which achieved pregnancy, in both hormonal conditions, with or without oestradiol and progesterone. Estradiol 223-233 adrenoceptor beta 2 Homo sapiens 64-72 15870697-5 2005 Estradiol increased and anti-estrogens (tamoxifen and ICI 164,384) downregulated the expression of both RARalpha and CRABPII proteins in T47D and MCF-7 cells. Estradiol 0-9 cellular retinoic acid binding protein 2 Homo sapiens 117-124 15930180-8 2005 Expression of beta-catenin in luminal and glandular epithelia was attenuated in mice treated with estradiol with trichostatin A or sodium butyrate. Estradiol 98-107 catenin (cadherin associated protein), beta 1 Mus musculus 14-26 15845768-9 2005 Consistent with these observations, treatment of UGT1A7-transfected cells with PKCepsilon-specific inhibitor peptide or general PKC inhibitors increased 17beta-estradiol catalysis between 5- and 11-fold, with parallel decreases in phosphoserine-432. Estradiol 160-169 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 49-55 15772982-0 2005 Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: protective effect by estradiol treatment in ovariectomized animals. Estradiol 140-149 aquaporin 4 Homo sapiens 46-57 15772982-6 2005 At the early phase, estradiol treatment highly prevented the LPS-induced disruption of the BBB and the induction of AQP4. Estradiol 20-29 aquaporin 4 Homo sapiens 116-120 15623811-15 2005 In contrast, RANKL is likely to mediate the effect of estradiol on osteoclastogenesis. Estradiol 54-63 TNF superfamily member 11 Homo sapiens 13-18 15689952-8 2005 Loss of PARP-1 resulted in reversal of the neuroprotective activity by the female sex steroid, 17beta estradiol. Estradiol 95-111 poly (ADP-ribose) polymerase family, member 1 Mus musculus 8-14 15722185-2 2005 We examined whether the stimulus effect of ethanol withdrawal (EW) alters the expression of PA in a manner that is prevented by 17beta-estradiol (E2). Estradiol 128-144 parvalbumin Rattus norvegicus 92-94 15845081-9 2005 Although estradiol did not alter the overall number of Fos-positive nuclei, it significantly increased the number of Fos/5-HT double-labelled cells in the medial and lateral DRN. Estradiol 9-18 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 117-120 15749960-11 2005 On PNDs 14 and 56, IGFBP-3 mRNA was decreased in the uterus of EV-treated ewes, but IGF-1R and IGFBP-4 mRNAs were not affected. Estradiol 63-65 insulin-like growth factor-binding protein 3 Ovis aries 19-26 15749960-12 2005 PAPP-A mRNA was increased by EV treatment on PND 14, but decreased on PND 56. Estradiol 29-31 pappalysin-1 Ovis aries 0-6 15593333-0 2005 In vitro inhibitory effects of non-steroidal antiinflammatory drugs on UDP-glucuronosyltransferase 1A1-catalysed estradiol 3beta-glucuronidation in human liver microsomes. Estradiol 113-122 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 71-102 16168119-9 2005 In addition, Cks1 and Skp2 expression were increased by estradiol in estrogen-dependent cell lines but were down-regulated by tamoxifen. Estradiol 56-65 CDC28 protein kinase regulatory subunit 1B pseudogene 7 Homo sapiens 13-17 15638876-14 2005 In addition, a significant positive correlation was found between serum RANKL/OPG ratios and oestradiol levels (r = 0.374, P < 0.001) in Spearman correlation analysis. Estradiol 93-103 TNF superfamily member 11 Homo sapiens 72-77 15638876-17 2005 In another multiple regression analysis, only serum oestradiol level was identified as a significant predictor for serum OPG or RANKL levels. Estradiol 52-62 TNF superfamily member 11 Homo sapiens 128-133 15638876-20 2005 Also, our data suggest that OPG and RANKL may be mediators of the effects of oestradiol in male bone metabolism. Estradiol 77-87 TNF superfamily member 11 Homo sapiens 36-41 15496504-2 2005 In this study, we demonstrate using intact cerebral blood vessels that 17beta-estradiol rapidly activates endothelial nitric-oxide synthase (eNOS) via a phosphoinositide-3 (PI-3) kinase-dependent pathway. Estradiol 71-87 nitric oxide synthase 3 Rattus norvegicus 141-145 15496504-6 2005 In parallel with NO production, 17beta-estradiol treatment rapidly increased phosphorylation of both eNOS (p-eNOS) and Akt (p-Akt). Estradiol 32-48 nitric oxide synthase 3 Rattus norvegicus 101-105 15496504-6 2005 In parallel with NO production, 17beta-estradiol treatment rapidly increased phosphorylation of both eNOS (p-eNOS) and Akt (p-Akt). Estradiol 32-48 nitric oxide synthase 3 Rattus norvegicus 109-113 16084662-1 2005 Our group and others have demonstrated that 17beta-estradiol (E2) induces neurotrophic and neuroprotective responses in hippocampal and cortical neurons which are dependent upon the Src/extracellular signal-regulated kinase (ERK) signaling pathways. Estradiol 44-60 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 182-185 16084662-1 2005 Our group and others have demonstrated that 17beta-estradiol (E2) induces neurotrophic and neuroprotective responses in hippocampal and cortical neurons which are dependent upon the Src/extracellular signal-regulated kinase (ERK) signaling pathways. Estradiol 62-64 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 182-185 15650246-5 2004 Under exactly the same experimental approach used for prostate studies, we observed that, once again, both estrogen (either estradiol or estrone) and FK induce a significant increase of GJIC in Huh7 cells, while exposure of HepG2 cells to FK produces only a limited rise of junctional activity in this cell line. Estradiol 124-133 MIR7-3 host gene Homo sapiens 194-198 15650250-3 2004 Following these results, experiments on the metabolism of estrogens, formation of depurinating DNA adducts, carcinogenicity, mutagenicity, and cellular transformation have led us to the hypothesis that certain metabolites of endogenous estrogens--in particular, estradiol(estrone)-3,4-quinones--can react with DNA to form depurinating adducts at the N-3 of Ade and the N-7 of Gua. Estradiol 262-271 DExD-box helicase 21 Homo sapiens 376-379 15345672-0 2004 Estradiol regulates the thioredoxin antioxidant system in the mouse uterus. Estradiol 0-9 thioredoxin 1 Mus musculus 24-35 15590986-10 2004 Moreover, both E2 and raloxifene induced both the phosphorylation of TERT at a putative Akt phosphorylation site and the association of nuclear factor kappaB with TERT. Estradiol 15-17 telomerase reverse transcriptase Rattus norvegicus 69-73 15590986-10 2004 Moreover, both E2 and raloxifene induced both the phosphorylation of TERT at a putative Akt phosphorylation site and the association of nuclear factor kappaB with TERT. Estradiol 15-17 telomerase reverse transcriptase Rattus norvegicus 163-167 15334653-3 2004 The goal of this study was to determine if treatment of bovine satellite cell (BSC) cultures with 17beta-estradiol (E(2)) or trenbolone (a synthetic androgen) directly affects proliferation rate or level of mRNA for estrogen receptor (ER)-alpha, androgen receptor, and growth factors that have been shown to affect muscle growth (insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, and myostatin). Estradiol 98-114 IGFI Bos taurus 330-364 15531723-7 2004 A semiquantitative RT-PCR analysis of rQSOX level across the estrous cycle and the fact that chronic administration of 17 beta-estradiol to ovariectomized rats led to a sustained up-regulation of rQSOX in the pituitary suggest that rQSOX expression is controlled by sex hormone levels. Estradiol 119-136 quiescin sulfhydryl oxidase 1 Rattus norvegicus 38-43 15531723-7 2004 A semiquantitative RT-PCR analysis of rQSOX level across the estrous cycle and the fact that chronic administration of 17 beta-estradiol to ovariectomized rats led to a sustained up-regulation of rQSOX in the pituitary suggest that rQSOX expression is controlled by sex hormone levels. Estradiol 119-136 quiescin sulfhydryl oxidase 1 Rattus norvegicus 196-201 15531723-7 2004 A semiquantitative RT-PCR analysis of rQSOX level across the estrous cycle and the fact that chronic administration of 17 beta-estradiol to ovariectomized rats led to a sustained up-regulation of rQSOX in the pituitary suggest that rQSOX expression is controlled by sex hormone levels. Estradiol 119-136 quiescin sulfhydryl oxidase 1 Rattus norvegicus 196-201 15609084-0 2004 Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells. Estradiol 11-28 matrix metallopeptidase 13 Rattus norvegicus 97-103 15280218-1 2004 beta-estradiol 17-(beta-D-glucuronide) (E217G) is a well known cholestatic agent and substrate of multidrug resistance-associated protein 2 (Mrp2), whereas beta-estradiol 3-(beta-D-glucuronide) (E23G) is a noncholestatic regioisomer of E217G with unknown transport properties. Estradiol 0-14 ATP binding cassette subfamily C member 2 Rattus norvegicus 141-145 15485793-1 2004 OBJECTIVE: To study the effect of brain-derived neurotrophin factor (BDNF) on the synthesis of estradiol and progesterone in human granulose-lutein cells (HGLCs) and the expression of steroidogenic acute regulatory factor (STAR) mRNA. Estradiol 95-104 brain derived neurotrophic factor Homo sapiens 34-67 15485793-1 2004 OBJECTIVE: To study the effect of brain-derived neurotrophin factor (BDNF) on the synthesis of estradiol and progesterone in human granulose-lutein cells (HGLCs) and the expression of steroidogenic acute regulatory factor (STAR) mRNA. Estradiol 95-104 brain derived neurotrophic factor Homo sapiens 69-73 15482376-0 2004 17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats. Estradiol 3-17 phosphatase and tensin homolog Rattus norvegicus 118-122 15482376-6 2004 In line with these results, 17 beta-estradiol significantly increased Akt and cyclic AMP response element binding protein (CREB) with increased Bcl-2 protein in the ischemic area, whereas the elevated the phosphatase and tensin homolog deleted from chromosome10 (PTEN) phosphorylation was significantly reduced with decreased Bax protein and cytochrome c release. Estradiol 28-45 phosphatase and tensin homolog Rattus norvegicus 263-267 15482376-8 2004 Taken together, it is suggested that suppression of cerebral ischemic injury by 17 beta-estradiol may be ascribed to the maxi-K channel opening-coupled downregulation of PTEN phosphorylation and upregulation of Akt and CREB phosphorylation with resultant increase in Bcl-2 protein and decrease in Bax protein and cytochrome c release. Estradiol 80-97 phosphatase and tensin homolog Rattus norvegicus 170-174 15542352-15 2004 Decreased serum total T(3), T(4), testosterone, estradiol and increased TSH were observed in PCB-exposed rats. Estradiol 48-57 pyruvate carboxylase Rattus norvegicus 93-96 15199063-6 2004 Confocal microscopy analysis showed nuclear colocalization of the TrxR1b with both estrogen receptor alpha and beta in estradiol-17beta-treated cells. Estradiol 119-135 thioredoxin reductase 1 Homo sapiens 66-71 15192077-2 2004 We previously reported that in the female rat uterus, the levels of specific AUF1 isoform mRNAs (p40/p45) were increased by 17 beta-estradiol (E2) treatment. Estradiol 143-145 heterogeneous nuclear ribonucleoprotein D Rattus norvegicus 77-81 15192077-2 2004 We previously reported that in the female rat uterus, the levels of specific AUF1 isoform mRNAs (p40/p45) were increased by 17 beta-estradiol (E2) treatment. Estradiol 143-145 caspase 1 Rattus norvegicus 101-104 15289619-5 2004 Suppression of AIB1 levels leads to ERalpha stabilization in the presence of 17beta-estradiol and, despite increased ERalpha levels, reduced recruitment of ERalpha to endogenous target gene promoters. Estradiol 77-93 ANIB1 Homo sapiens 15-19 15243295-2 2004 Our experiments aimed to test the hypothesis that daidzein and 17 beta-estradiol enhance endothelium-dependent relaxation through an increase in NO synthesis due to an increase in activity or expression of endothelial nitric oxide synthase (eNOS). Estradiol 63-80 nitric oxide synthase 3 Rattus norvegicus 206-239 15243295-2 2004 Our experiments aimed to test the hypothesis that daidzein and 17 beta-estradiol enhance endothelium-dependent relaxation through an increase in NO synthesis due to an increase in activity or expression of endothelial nitric oxide synthase (eNOS). Estradiol 63-80 nitric oxide synthase 3 Rattus norvegicus 241-245 15243295-6 2004 Daidzein and 17 beta-estradiol did not alter eNOS protein in endothelium-intact aortae but reduced expression of caveolin-1 and increased expression of calmodulin, changes that would account for an increase in eNOS activity. Estradiol 13-30 nitric oxide synthase 3 Rattus norvegicus 210-214 15243295-8 2004 Daidzein or 17 beta-estradiol treatment selectively enhances endothelium-dependent relaxation in male rats through an increase in eNOS activity. Estradiol 12-29 nitric oxide synthase 3 Rattus norvegicus 130-134 15381448-3 2004 On one hand, BRCA1 expression could be induced by estradiol in experimental models. Estradiol 50-59 BRCA1 DNA repair associated Homo sapiens 13-18 15232065-5 2004 Replacement with DHT and testosterone alone or in combination with estradiol caused the recovery of AR expression to control levels. Estradiol 67-76 androgen receptor Rattus norvegicus 100-102 15481788-1 2004 In the present study, the effects of 17beta-estradiol (E2) and phytoestrogen alpha-zearalanol (ZAL) on tissue factor (TF) in plasma of ovariectomized (OVX) rats and human umbilical vein endothelial cells (HUVECs) were investigated. Estradiol 37-53 coagulation factor III, tissue factor Rattus norvegicus 103-116 15481788-1 2004 In the present study, the effects of 17beta-estradiol (E2) and phytoestrogen alpha-zearalanol (ZAL) on tissue factor (TF) in plasma of ovariectomized (OVX) rats and human umbilical vein endothelial cells (HUVECs) were investigated. Estradiol 37-53 coagulation factor III, tissue factor Rattus norvegicus 118-120 15094777-0 2004 Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells. Estradiol 72-81 fatty acid synthase Homo sapiens 31-50 15188374-0 2004 17 beta-estradiol regulates cytokine release through modulation of CD16 expression in monocytes and monocyte-derived macrophages. Estradiol 0-17 Fc gamma receptor IIIa Homo sapiens 67-71 15188374-5 2004 We undertook this study to test the hypothesis that decreased concentrations of estrogen (17 beta-estradiol) directly cause an increase in CD16 expression, resulting in increased release of proinflammatory cytokines from monocytes and/or macrophages upon receptor binding. Estradiol 90-107 Fc gamma receptor IIIa Homo sapiens 139-143 15188374-8 2004 Cytokine release from 17 beta-estradiol-treated or untreated monocytes was then quantitated by enzyme-linked immunosorbent assay and FACS after crosslinking the receptor with anti-CD16 antibodies. Estradiol 22-39 Fc gamma receptor IIIa Homo sapiens 180-184 15188374-10 2004 CD16 receptor levels on CD14+, transforming growth factor beta-treated primary monocytes also increased in cells deprived of 17 beta-estradiol. Estradiol 125-142 Fc gamma receptor IIIa Homo sapiens 0-4 15117337-7 2004 The elevation of hypothalamic ANP (two-fold) and ANP receptors by treatment of ovariectomized rats with 17beta-oestradiol (25 micro g/rat, 10 days) was abolished by coadministration of progesterone. Estradiol 104-121 natriuretic peptide A Rattus norvegicus 30-33 15117337-7 2004 The elevation of hypothalamic ANP (two-fold) and ANP receptors by treatment of ovariectomized rats with 17beta-oestradiol (25 micro g/rat, 10 days) was abolished by coadministration of progesterone. Estradiol 104-121 natriuretic peptide A Rattus norvegicus 49-52 15117337-8 2004 Thus, we concluded that elevated oestradiol at term stimulates ANP synthesis and paracrine ANP activation in the hypothalamus. Estradiol 33-43 natriuretic peptide A Rattus norvegicus 63-66 15117337-8 2004 Thus, we concluded that elevated oestradiol at term stimulates ANP synthesis and paracrine ANP activation in the hypothalamus. Estradiol 33-43 natriuretic peptide A Rattus norvegicus 91-94 15117337-9 2004 Overall, we provide experimental, anatomical and molecular evidence for ANP regulation in hypothalamic neurones at preterm and after 17beta-oestradiol stimulation. Estradiol 133-150 natriuretic peptide A Rattus norvegicus 72-75 15225803-0 2004 A combined treatment with 1alpha,25-dihydroxy-vitamin D3 and 17beta-estradiol reduces the expression of heat shock protein-32 (HSP-32) following cerebral cortical ischemia. Estradiol 61-77 heme oxygenase 1 Rattus norvegicus 104-125 15225803-0 2004 A combined treatment with 1alpha,25-dihydroxy-vitamin D3 and 17beta-estradiol reduces the expression of heat shock protein-32 (HSP-32) following cerebral cortical ischemia. Estradiol 61-77 heme oxygenase 1 Rattus norvegicus 127-133 15225803-2 2004 Here, we studied the effects of 1alpha,25-(OH)(2)-vitamin D(3) or 17beta-estradiol or their combined application on heat shock protein-32 (HSP-32) distribution after focal cortical ischemia using the well established photothrombosis model. Estradiol 66-82 heme oxygenase 1 Rattus norvegicus 116-137 15225803-2 2004 Here, we studied the effects of 1alpha,25-(OH)(2)-vitamin D(3) or 17beta-estradiol or their combined application on heat shock protein-32 (HSP-32) distribution after focal cortical ischemia using the well established photothrombosis model. Estradiol 66-82 heme oxygenase 1 Rattus norvegicus 139-145 15225803-7 2004 In contrast to non-lesioned rats, in lesioned animals a significant increase in heat shock protein-32 expression occurred which was slightly, but non-significantly altered in the groups treated either with 1alpha,25-(OH)(2)-vitamin D(3) or 17beta-estradiol alone when compared to the solvent-treated control group. Estradiol 240-256 heme oxygenase 1 Rattus norvegicus 80-101 15225803-8 2004 Only the combined treatment with 1alpha,25-(OH)(2)-vitamin D(3) and 17beta-estradiol resulted in a significant reduction of glial heat shock protein-32 immunoreactivity within the lesion-remote cortical areas supplied by the affected middle cerebral artery (MCA), indicating that both steroids act synergistically in a protective manner. Estradiol 68-84 heme oxygenase 1 Rattus norvegicus 130-151 15225808-1 2004 In cultured human vascular smooth muscle cells (VSMC), estradiol-17beta (E2) induced a biphasic effect on DNA synthesis, i.e., stimulation at low concentrations and inhibition at high concentrations. Estradiol 55-71 cystatin 12, pseudogene Homo sapiens 73-75 14996734-7 2004 The PCDGF/GP88-overexpressing cells formed tumors in ovariectomized nude mice in the absence of estradiol and in its presence, in contrast to MCF-7 cells. Estradiol 96-105 granulin Mus musculus 4-9 14978252-5 2004 In contrast, treatment of ovariectomized female mice or castrated male mice with 17beta-estradiol causes a further reduction in CYP2J5 expression. Estradiol 81-97 cytochrome P450, family 2, subfamily j, polypeptide 5 Mus musculus 128-134 14764897-1 2004 Our previous studies demonstrated that 17beta-estradiol (E2) rapidly induces the interaction of estrogen receptor alpha (ERalpha) with the adapter protein Shc, the translocation of ERalpha to the cell membrane, and the formation of dynamic membrane structures in MCF-7 breast cancer cells. Estradiol 39-55 SHC adaptor protein 1 Homo sapiens 155-158 14871858-1 2004 UDP-glucuronosyltransferase (UGT) 1A1 is involved in the inactivation of estradiol (E(2)) and its oxidized metabolites. Estradiol 73-82 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 0-37 14871858-11 2004 These observations suggest that lower expression of UGT1A1 decreases the risk of endometrial cancer by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of E(2), in the endometrium. Estradiol 185-189 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 52-58 15084353-1 2004 Pretreatment with 1 nM 1,25-dihydroxyvitamin D(3) (1,25), or non-hypercalcemic Vitamin D analogs, upregulated the response of creatine kinase (CK) to 17beta-estradiol (30 nM E(2)), raloxifene (3000 nM RAL) or dihydrotestosterone (300 nM DHT) in primary human bone cells. Estradiol 150-166 RAS like proto-oncogene A Homo sapiens 201-204 14694190-10 2004 Taken together with our previous finding of a P450scc-containing neuronal system for pregnenolone synthesis, these results imply that 17beta-estradiol is synthesized by P45017alpha and P450 aromatase localized in hippocampal neurons from endogenous cholesterol. Estradiol 134-150 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 46-53 14734489-6 2004 Estradiol binds to cell membrane-associated ERs, physically associates with the adaptor protein Shc, and induces its phosphorylation. Estradiol 0-9 SHC adaptor protein 1 Homo sapiens 96-99 14734489-8 2004 These nongenomic effects of estradiol produced biological effects, as evidenced by Elk-1 activation and by morphological changes in cell membranes. Estradiol 28-37 ETS transcription factor ELK1 Homo sapiens 83-88 15106361-7 2004 Interestingly, TIMP-2 expression was down-regulated by 17 beta-estradiol and 17 alpha-hydroxyprogesterone. Estradiol 55-72 TIMP metallopeptidase inhibitor 2 Homo sapiens 15-21 14695685-9 2004 However, in the presence of estradiol 17beta, both PR isoforms and mRNA transcripts were increased as a correlate of ER mRNA transcription, suggesting both transcriptional and translational effects; these effects were inhibited by testosterone and progesterone treatments. Estradiol 28-44 estrogen receptor Chrysemys picta 117-119 14980726-1 2004 Using hippocampal primary cell cultures at 14 days in vitro (div), we have investigated actions of 17-beta estradiol (E; 10 nM) on the phosphorylation of CREB and on signaling pathways that regulate CREB phosphorylation. Estradiol 99-116 cAMP responsive element binding protein 1 Homo sapiens 154-158 14638944-0 2003 Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior. Estradiol 96-105 prostaglandin D2 synthase (brain) Mus musculus 13-52 14599727-5 2003 Following precontraction, the dose-response relationships for VIP and PACAP were evaluated.Treatment with 17beta-estradiol significantly improved the maximum VIP-mediated vasodilation (E(max), percentage of precontraction) in proximal coronary arteries (45.8+/-9.6% vs. 24.1+/-3.7%, p<0.05). Estradiol 106-122 LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide Oryctolagus cuniculus 70-75 14600091-15 2003 CONCLUSIONS: Growth of raloxifene-resistant MCF-7/Ral cells in vitro and in vivo is repressed by estradiol treatment by a mechanism involving G2/M-phase arrest, decreased NF-kappaB activity, and increased Fas expression to induce apoptosis. Estradiol 97-106 RAS like proto-oncogene A Homo sapiens 50-53 14578376-5 2003 The effect of 17beta-estradiol on fibulin-3 production was studied in COS-7 and ARPE-19 cells. Estradiol 14-30 EGF containing fibulin extracellular matrix protein 1 Homo sapiens 34-43 14713365-3 2003 17beta-estradiol has been shown to activate membrane-bound guanylate cyclase GC-A in PC12 cells in a non-genomic manner. Estradiol 0-16 grancalcin Rattus norvegicus 77-81 12928058-1 2003 17-beta-Estradiol (E2), by activating Src and ERK/MAP kinases, enhances NMDA receptor phosphorylation and function. Estradiol 0-17 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 38-41 14517261-4 2003 Here we show that a strictly conserved E2 asparagine residue is critical for catalysis of E2- and E2/RING E3-dependent isopeptide bond formation, but dispensable for upstream and downstream reactions of Ub thiol ester formation. Estradiol 39-41 cystatin 12, pseudogene Homo sapiens 90-108 14519485-1 2003 OBJECTIVE: To determine the expression and intracellular localization of protein phosphatases 2A (PP2A) and 2B (PP2B), protein kinase A (PKA), and A-kinase anchoring protein (AKAP79), and expression of PKA (RII subunit) binding to AKAP79 in human postmenopausal and pregnant myometrium and to correlate their expressions to blood levels of estradiol, progesterone, and oxytocin. Estradiol 340-349 A-kinase anchoring protein 5 Homo sapiens 175-181 12941156-11 2003 Co-cultured cells demonstrated an increase in progesterone production with increasing SCF dose (P < 0.001) and an increase in oestradiol synthesis at the highest dose of SCF (100 ng/ml). Estradiol 129-139 KIT ligand Homo sapiens 173-176 12896805-0 2003 Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953. Estradiol 116-125 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 91-96 12834435-0 2003 Short-term effect of oestradiol on neurokinin B mRNA expression in the infundibular nucleus of ewes. Estradiol 21-31 tachykinin-3 Ovis aries 35-47 12834435-4 2003 After cloning a specific ovine NKB antisense riboprobe, we examined the effects of a short oestradiol treatment (4 h subcutaneously) on the expression of NKB mRNA in the caudal part of the infundibular nucleus of progesterone-primed ovariectomized ewes. Estradiol 91-101 tachykinin-3 Ovis aries 154-157 12834435-5 2003 We demonstrated that oestradiol decreased both the level of NKB mRNA expression (34%) and the number of cells containing NKB mRNA (43%). Estradiol 21-31 tachykinin-3 Ovis aries 60-63 12834435-5 2003 We demonstrated that oestradiol decreased both the level of NKB mRNA expression (34%) and the number of cells containing NKB mRNA (43%). Estradiol 21-31 tachykinin-3 Ovis aries 121-124 14973372-8 2003 In ovariectomized mice supplemented with estradiol but lacking measurable progesterone, PR-B-expressing tumors grow to twice the size of PR-A-expressing ones. Estradiol 41-50 progesterone receptor Mus musculus 88-92 14523355-4 2003 RESULTS: At preovulatory concentrations, estradiol enhanced significantly IFN-gamma, IL-12 and IL-10, but not TNF-alpha, production levels and reversed the suppressive effect of hydrocortisone in PHA+LPS stimulated whole blood. Estradiol 41-50 interleukin 10 Homo sapiens 95-100 12723952-2 2003 We have previously shown with 16alpha-substituted analogues of estradiol that carboxylates proximal to the steroid ring neither bind to the estrogen receptor nor activate estrogen-responsive genes. Estradiol 63-72 ATPase H+ transporting accessory protein 1 Homo sapiens 30-37 12709027-5 2003 Expression of CD4 and CCR5 on uterine epithelial cells is high throughout the proliferative phase of the menstrual cycle when blood levels of oestradiol are high. Estradiol 142-152 C-C motif chemokine receptor 5 Homo sapiens 22-26 12709027-7 2003 During the secretory phase of the cycle when both oestradiol and progesterone are elevated, CD4 and CCR5 expression decreased whereas CXCR4 expression remained elevated. Estradiol 50-60 C-C motif chemokine receptor 5 Homo sapiens 100-104 12554767-9 2003 In vitro kinase assays using immunoprecipitation and anti-Akt1, -Akt2, and -Akt3-specific antibodies demonstrated that Akt1 is activated by estradiol in MCF-7 cells whereas Akt3 is the activated isoform in ER-negative MDA-MB231 cells, implying that selective activation of Akt subtypes plays a role in the actions of estradiol. Estradiol 317-326 AKT serine/threonine kinase 3 Homo sapiens 173-177 34791329-4 2022 In addition, we investigated the influence of testosterone (T) and estradiol (E2) on TNC levels in primary neuronal cultures. Estradiol 78-80 tenascin C Homo sapiens 85-88 34791329-7 2022 Serum TNC concentrations were negatively associated with levels of E2 and T and with the T/E2 ratio. Estradiol 67-69 tenascin C Homo sapiens 6-9 34791329-7 2022 Serum TNC concentrations were negatively associated with levels of E2 and T and with the T/E2 ratio. Estradiol 91-93 tenascin C Homo sapiens 6-9 34791329-10 2022 Incubating pheochromocytoma 12 cells with the combination of T and E2 greatly decreased TNC levels in the culture medium. Estradiol 67-69 tenascin C Homo sapiens 88-91 34791329-11 2022 CONCLUSION: Increased TNC levels may predict imbalance between T and E2 in patients with depression, and gonadal hormones may modulate TNC expression in vivo. Estradiol 69-71 tenascin C Homo sapiens 22-25 34773076-6 2021 Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Estradiol 42-58 G protein-coupled estrogen receptor 1 Homo sapiens 160-164 34773076-6 2021 Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Estradiol 42-58 serine/threonine kinase 4 Homo sapiens 174-211 34773076-6 2021 Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Estradiol 42-58 serine/threonine kinase 4 Homo sapiens 213-217 34773076-6 2021 Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Estradiol 60-62 G protein-coupled estrogen receptor 1 Homo sapiens 160-164 34773076-6 2021 Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Estradiol 60-62 serine/threonine kinase 4 Homo sapiens 174-211 34773076-6 2021 Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Estradiol 60-62 serine/threonine kinase 4 Homo sapiens 213-217 34561233-13 2021 We demonstrate that male aromatase neurons convert testosterone to estradiol to regulate kisspeptin neuron activity. Estradiol 67-76 KiSS-1 metastasis-suppressor Mus musculus 89-99 34795643-0 2021 Optogenetic Activation of Arcuate Kisspeptin Neurons Generates a Luteinizing Hormone Surge-Like Secretion in an Estradiol-Dependent Manner. Estradiol 112-121 KiSS-1 metastasis-suppressor Mus musculus 34-44 34379733-2 2021 In female rodents, estrogen-sensitive kisspeptin neurons in the rostral anteroventral periventricular (AVPV) hypothalamus are thought to mediate estradiol (E2)-induced positive feedback induction of the preovulatory luteinizing hormone (LH) surge. Estradiol 145-154 KiSS-1 metastasis-suppressor Mus musculus 38-48 34379733-2 2021 In female rodents, estrogen-sensitive kisspeptin neurons in the rostral anteroventral periventricular (AVPV) hypothalamus are thought to mediate estradiol (E2)-induced positive feedback induction of the preovulatory luteinizing hormone (LH) surge. Estradiol 156-158 KiSS-1 metastasis-suppressor Mus musculus 38-48 34379733-4 2021 While E2 effects on kisspeptin neurons have been well-studied, progesterone"s regulation of kisspeptin neurons is less understood. Estradiol 6-8 KiSS-1 metastasis-suppressor Mus musculus 20-30 34379733-9 2021 We found that targeted upregulation of PGR in kisspeptin neurons exclusively in the AVPV is sufficient to restore proper E2-induced LH surges in KissPRKO females, suggesting that this specific kisspeptin population is a key target of the necessary progesterone action for the surge. Estradiol 121-123 progesterone receptor Mus musculus 39-42 34379733-9 2021 We found that targeted upregulation of PGR in kisspeptin neurons exclusively in the AVPV is sufficient to restore proper E2-induced LH surges in KissPRKO females, suggesting that this specific kisspeptin population is a key target of the necessary progesterone action for the surge. Estradiol 121-123 KiSS-1 metastasis-suppressor Mus musculus 46-56 34628937-1 2021 We tested the hypothesis that CYP1B1 (cytochrome P450 1B1)-17beta-estradiol metabolite 2-methoxyestradiol protects against Ang II (angiotensin II)-induced hypertension by inhibiting group IV cPLA2alpha (cytosolic phospholipase A2alpha) activity and production of prohypertensive eicosanoids in female mice. Estradiol 65-75 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 30-36 34628937-1 2021 We tested the hypothesis that CYP1B1 (cytochrome P450 1B1)-17beta-estradiol metabolite 2-methoxyestradiol protects against Ang II (angiotensin II)-induced hypertension by inhibiting group IV cPLA2alpha (cytosolic phospholipase A2alpha) activity and production of prohypertensive eicosanoids in female mice. Estradiol 65-75 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 38-57 34698602-3 2021 UGT1A1 catalyzed beta-estradiol 3-beta-D-glucuronide formation showed allosteric sigmoidal kinetics in all enzyme systems; while UGT1A3 catalyzed CDCA 24-acyl-beta-D-glucuronide formation exhibited Michaelis-Menten kinetics in HLM, substrate inhibition kinetics in HIM and rUGT systems. Estradiol 17-31 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 0-6 34771486-7 2021 E2 increases FASN levels in MDA-MB-231 cells regardless of miR-33a cellular levels. Estradiol 0-2 fatty acid synthase Homo sapiens 13-17 34721835-9 2021 LiCl plus estradiol protected SH-SY5Y cells and zebrafish against 6-OHDA-induced damage on neurons than LiCl or estradiol alone groups via p-P38, p-Akt, Bcl-2, and caspase-3 cascade. Estradiol 10-19 mitogen-activated protein kinase 14a Danio rerio 141-144 34721835-9 2021 LiCl plus estradiol protected SH-SY5Y cells and zebrafish against 6-OHDA-induced damage on neurons than LiCl or estradiol alone groups via p-P38, p-Akt, Bcl-2, and caspase-3 cascade. Estradiol 112-121 mitogen-activated protein kinase 14a Danio rerio 141-144 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 interleukin 17A Homo sapiens 76-81 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 interleukin 18 Homo sapiens 83-88 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 KIT ligand Homo sapiens 90-106 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 KIT ligand Homo sapiens 108-111 34733276-6 2021 Furthermore, we found significantly increased plasma levels of IL-6, IL-12, IL-17, IL-18, stem cell factor (SCF), and IL-21/IL-23 in SLE patients compared to healthy controls, and those levels positively correlated with the plasma levels of 17beta-estradiol. Estradiol 241-257 interleukin 21 Homo sapiens 118-123 34733276-8 2021 In vitro treatment of PBMCs from either SLE patients or healthy controls with 17beta-estradiol at physiological concentration (~50 pg/ml) also significantly increased secretion of many pro-inflammatory cytokines and chemokines (IL-6, IL-12, IL-17, IL-8, IFN-gamma; MIP1alpha, and MIP1beta) in both groups. Estradiol 78-94 interleukin 17A Homo sapiens 241-246 34631701-4 2021 We found that E2 rapidly decreased the surface movement of AMPAR via membrane G protein-coupled estrogen receptor 1 (GPER1) in neurites in a dose-dependent manner. Estradiol 14-16 G protein-coupled estrogen receptor 1 Homo sapiens 78-115 34631701-4 2021 We found that E2 rapidly decreased the surface movement of AMPAR via membrane G protein-coupled estrogen receptor 1 (GPER1) in neurites in a dose-dependent manner. Estradiol 14-16 G protein-coupled estrogen receptor 1 Homo sapiens 117-122 34631701-5 2021 The cortical actin network played a pivotal role in the GPER1 mediated effects of E2 on the surface mobility of AMPAR. Estradiol 82-84 G protein-coupled estrogen receptor 1 Homo sapiens 56-61 34538551-9 2022 RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation. Estradiol 107-116 androgen receptor Rattus norvegicus 322-324 34538551-9 2022 RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation. Estradiol 118-120 androgen receptor Rattus norvegicus 322-324 34314376-8 2021 Resistin decreased P4 and increased oestradiol (E2) secretion via changing in steroidogenic enzymes expression and via the activation of protein kinase A (PKA) and mitogen-activated protein kinase (MAP3/1), increased the expression of receptors LHCGR and ESR2 and decreased the expression of PGR. Estradiol 36-46 modulator of apoptosis 1 Homo sapiens 198-204 34314376-8 2021 Resistin decreased P4 and increased oestradiol (E2) secretion via changing in steroidogenic enzymes expression and via the activation of protein kinase A (PKA) and mitogen-activated protein kinase (MAP3/1), increased the expression of receptors LHCGR and ESR2 and decreased the expression of PGR. Estradiol 48-50 modulator of apoptosis 1 Homo sapiens 198-204 34391879-4 2022 Here, we report that HAND1 inhibits human trophoblastic progesterone (P4) and estradiol (E2) from cholesterol through down-regulation of the expression of steroidogenic enzymes including aromatase, P450 cholesterol side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase type 1 (3beta-HSD1). Estradiol 78-87 heart and neural crest derivatives expressed 1 Homo sapiens 21-26 34391879-4 2022 Here, we report that HAND1 inhibits human trophoblastic progesterone (P4) and estradiol (E2) from cholesterol through down-regulation of the expression of steroidogenic enzymes including aromatase, P450 cholesterol side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase type 1 (3beta-HSD1). Estradiol 89-91 heart and neural crest derivatives expressed 1 Homo sapiens 21-26 34229476-8 2021 Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15. Estradiol 17-26 G protein-coupled estrogen receptor 1 Mus musculus 188-225 34229476-8 2021 Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15. Estradiol 17-26 G protein-coupled estrogen receptor 1 Mus musculus 227-231 34229476-8 2021 Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15. Estradiol 28-30 G protein-coupled estrogen receptor 1 Mus musculus 188-225 34229476-8 2021 Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15. Estradiol 28-30 G protein-coupled estrogen receptor 1 Mus musculus 227-231 34440676-0 2021 Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds. Estradiol 54-63 neuroglobin Homo sapiens 8-19 34440676-2 2021 Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain neuronal and glial cell adaptation to injury. Estradiol 52-61 neuroglobin Homo sapiens 15-26 34440676-3 2021 In this paper, we will discuss the role of neuroglobin in the neuroprotective mechanisms elicited by estradiol acting on neurons, astrocytes and microglia. Estradiol 101-110 neuroglobin Homo sapiens 43-54 34359570-5 2021 In vitro, progesterone- and 17beta-oestradiol-induced VEGF production promoting cell proliferation and androgens are involved in the formation of vascular-like structures. Estradiol 28-45 vascular endothelial growth factor A Mus musculus 54-58 34430566-10 2021 In parallel, there were 17beta-estradiol effects in reducing MMP2 (P=0.0043), MMP9 (P=0.011), and IL-6 (P=0.024). Estradiol 24-40 matrix metallopeptidase 9 Rattus norvegicus 78-82 34247803-0 2021 Interleukin-33 promotes invasiveness of human ovarian endometriotic stromal cells through the ST2/MAPK/MMP-9 pathway activated by 17beta-estradiol. Estradiol 130-146 ST2 Homo sapiens 94-97 34247803-0 2021 Interleukin-33 promotes invasiveness of human ovarian endometriotic stromal cells through the ST2/MAPK/MMP-9 pathway activated by 17beta-estradiol. Estradiol 130-146 matrix metallopeptidase 9 Homo sapiens 103-108 34247803-10 2021 RESULTS: We found that 17beta-estradiol could increase the expression of IL-33 and ST2 through the estrogen receptor pathway in hOVEN-SCs. Estradiol 23-39 ST2 Homo sapiens 83-86 34247803-13 2021 CONCLUSION: Our main finding is that 17beta-estradiol could increase IL-33 expression through the estrogen receptor pathway and activate MMP-9 expression in and invasion ability of hOVEN-SCs through the IL-33/ST2/MAPK signaling pathway. Estradiol 37-53 matrix metallopeptidase 9 Homo sapiens 137-142 34247803-13 2021 CONCLUSION: Our main finding is that 17beta-estradiol could increase IL-33 expression through the estrogen receptor pathway and activate MMP-9 expression in and invasion ability of hOVEN-SCs through the IL-33/ST2/MAPK signaling pathway. Estradiol 37-53 ST2 Homo sapiens 209-212 34182538-3 2021 Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs. Estradiol 309-326 G protein-coupled estrogen receptor 1 Homo sapiens 25-30 34182538-3 2021 Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs. Estradiol 309-326 G protein-coupled estrogen receptor 1 Homo sapiens 236-241 34182538-3 2021 Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs. Estradiol 309-326 G protein-coupled estrogen receptor 1 Homo sapiens 350-355 34182538-3 2021 Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs. Estradiol 327-329 G protein-coupled estrogen receptor 1 Homo sapiens 25-30 34182538-3 2021 Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs. Estradiol 327-329 G protein-coupled estrogen receptor 1 Homo sapiens 236-241 34199180-4 2021 CTSS overexpression significantly promoted the secretion of progesterone (P4) and estrogen (E2) by increasing the expression of STAR and CYP19A1 (p < 0.05). Estradiol 92-94 steroidogenic acute regulatory protein, mitochondrial Oryctolagus cuniculus 128-132 34199180-4 2021 CTSS overexpression significantly promoted the secretion of progesterone (P4) and estrogen (E2) by increasing the expression of STAR and CYP19A1 (p < 0.05). Estradiol 92-94 aromatase Oryctolagus cuniculus 137-144 34206065-0 2021 17-beta Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway. Estradiol 0-17 heme oxygenase 1 Rattus norvegicus 130-134 35500753-5 2022 In this study, we investigated whether beta-estradiol treatment modulates SLC26A6 expression and its bicarbonate or oxalate transporting activity and affects the proliferative and migratory ability of A549 cells. Estradiol 39-53 solute carrier family 26 member 6 Homo sapiens 74-81 35500753-6 2022 The beta-estradiol stimulation attenuated oxalate or bicarbonate transporting activities through SLC26A6. Estradiol 4-18 solute carrier family 26 member 6 Homo sapiens 97-104 35500753-8 2022 beta-estradiol-mediated cellular migration was independent of SLC26A6 transporter activity, whereas enhanced SLC26A6 expression attenuated cellular migration even in the presence of beta-estradiol treatment. Estradiol 0-14 solute carrier family 26 member 6 Homo sapiens 62-69 35500753-8 2022 beta-estradiol-mediated cellular migration was independent of SLC26A6 transporter activity, whereas enhanced SLC26A6 expression attenuated cellular migration even in the presence of beta-estradiol treatment. Estradiol 0-14 solute carrier family 26 member 6 Homo sapiens 109-116 35500753-9 2022 These results indicate beta-estradiol treatment enhances cancer cell migration and dysregulates oxalate transport by inhibiting SLC26A6 activity, suggesting reduced oxalate transporting activity may involve in the oxalate homeostasis. Estradiol 23-37 solute carrier family 26 member 6 Homo sapiens 128-135 35138554-2 2022 The actions of E2 are mediated by two classical nuclear estrogen receptors alpha (ERalpha) and beta (ERbeta) and the G protein-coupled estrogen receptor (GPER). Estradiol 15-17 G protein-coupled estrogen receptor 1 Mus musculus 117-152 35138554-2 2022 The actions of E2 are mediated by two classical nuclear estrogen receptors alpha (ERalpha) and beta (ERbeta) and the G protein-coupled estrogen receptor (GPER). Estradiol 15-17 G protein-coupled estrogen receptor 1 Mus musculus 154-158 35344811-10 2022 E2 inhibited the expression of FOXO3a and elevated PD-L1 expression, thereby promoting the immune escape of NSCLC cells. Estradiol 0-2 forkhead box O3 Mus musculus 31-37 35344811-11 2022 In vivo results showed that E2 facilitated the growth and metastasis of NSCLC cells in nude mice by elevating ERbeta via SIRT1/FOXO3a/PD-L1 axis. Estradiol 28-30 forkhead box O3 Mus musculus 127-133 35470579-13 2022 CCL2 and CCL7 protein and mRNA expression was increased in OVX mice and aged female mice, but the increases were attenuated by E2 and Bnd. Estradiol 127-129 chemokine (C-C motif) ligand 2 Mus musculus 0-4 35470579-13 2022 CCL2 and CCL7 protein and mRNA expression was increased in OVX mice and aged female mice, but the increases were attenuated by E2 and Bnd. Estradiol 127-129 chemokine (C-C motif) ligand 7 Mus musculus 9-13 35593921-8 2022 IFNbeta induced E2 production in the preadipocytes isolated from the control mice, but such E2 production was far lower in the Ifi204-AKO preadipocytes. Estradiol 16-18 interferon alpha Mus musculus 0-7 35552680-5 2022 Curiously, in PCSK9-deficient mice, an alternative to the downregulation of the surface levels of the LDLR by PCSK9 is taking place in the liver of female mice in a 17beta-estradiol-dependent manner by still an unknown mechanism. Estradiol 172-181 low density lipoprotein receptor Mus musculus 102-106 35532160-8 2022 We also report that CFTR expression is increased by estradiol in the macaque cervix both in vitro and in vivo in Rhesus macaques treated with artificial menstrual cycles. Estradiol 52-61 CF transmembrane conductance regulator Macaca mulatta 20-24 35589416-6 2022 The suppressive effect of estradiol on the production of IL-1beta and IL-17A was abolished in mice lacking estrogen receptors in neutrophils and macrophages (Esr1f/fEsr2f/fLysM-Cre+ mice). Estradiol 26-35 interleukin 17A Mus musculus 70-76 35438966-3 2022 It was found that the serum levels of progesterone, testosterone, and estradiol were significantly increased after 0.015 and 0.15 mg/kg of PFOA exposure, and the expression of Star, a key rate-limiting gene, was up-regulated, while other steroidogenic genes Cyp11a1, Hsd3b, Cyp17a1, and Hsd17b were down-regulated. Estradiol 70-79 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 258-265 35343535-3 2022 Anti-E2 dominates over syn-E2 (kinetic anti-E2 preference) and the thermodynamically-favored SN2 (wider reactive anti-E2 attack angle range). Estradiol 5-7 synemin Homo sapiens 23-26 35343535-5 2022 The HF products are vibrationally cold, especially for proton abstraction, and their rotational excitation increases for proton abstraction, anti-E2, and syn-E2, in order. Estradiol 158-160 synemin Homo sapiens 154-157 35350405-10 2022 Treatment of MCF-7 cells with ER agonists, estradiol (E2) and diarylpropionitrile (DPN), resulted in increases in alphaKlotho expression and supernatant levels of both agonists, demonstrating a direct association between the ER and Klotho production; of note, the ERbeta-specific agonist DPN tripled alphaKlotho expression when compared to E2 (P=0.078). Estradiol 43-52 klotho Homo sapiens 232-238 35176672-0 2022 17beta-estradiol rescues the damage of thiazolidinedione on chicken Sertoli cell proliferation via adiponectin. Estradiol 0-16 adiponectin, C1Q and collagen domain containing Gallus gallus 99-110 35328539-4 2022 The aim of this study is to elucidate whether the kappa-opioid receptor (k-OR) system is involved in mediating body weight changes associated with E2 withdrawal. Estradiol 147-149 opioid receptor, kappa 1 Mus musculus 50-77 35328539-8 2022 These findings will help to define new therapies to manage metabolic disorders associated with low/null E2 levels based on the modulation of central k-OR signaling. Estradiol 104-106 opioid receptor, kappa 1 Mus musculus 149-153 35074437-7 2022 Of considerable recent interest is how E2 and E3 might switch their functional partnerships via UBE2O, which suggests an emerging significance on how UBE2O might influence E2-E3 pairing. Estradiol 172-174 cystatin 12, pseudogene Homo sapiens 39-48 35074437-7 2022 Of considerable recent interest is how E2 and E3 might switch their functional partnerships via UBE2O, which suggests an emerging significance on how UBE2O might influence E2-E3 pairing. Estradiol 172-174 ubiquitin conjugating enzyme E2 O Homo sapiens 96-101 35074437-7 2022 Of considerable recent interest is how E2 and E3 might switch their functional partnerships via UBE2O, which suggests an emerging significance on how UBE2O might influence E2-E3 pairing. Estradiol 172-174 ubiquitin conjugating enzyme E2 O Homo sapiens 150-155 35050457-12 2022 Following treatment with 10 nM DHT, the expression of collagen I, fibronectin, TGF-beta1, and Smad3 was increased, and the expression of elastin and Smad7 was decreased in WPMY-1 cells with increasing E2 concentration treatment compared to the 10 nM DHT group (p < 0.05, p < 0.01). Estradiol 201-203 elastin Homo sapiens 137-144 35050457-13 2022 Following treatment with 5 pM E2, the expression of collagen I, fibronectin, TGF-beta1, and Smad3 was decreased, and elastin and Smad7 expression was increased with increasing DHT concentration compared to the 5 pM E2 group (p < 0.05, p < 0.01). Estradiol 30-32 elastin Homo sapiens 117-124 35050457-13 2022 Following treatment with 5 pM E2, the expression of collagen I, fibronectin, TGF-beta1, and Smad3 was decreased, and elastin and Smad7 expression was increased with increasing DHT concentration compared to the 5 pM E2 group (p < 0.05, p < 0.01). Estradiol 215-217 elastin Homo sapiens 117-124 35050457-14 2022 Compared to the 10 nM DHT + 5 pM E2 group, the expressions of collagen I and fibronectin were decreased; the expression of elastin was increased in WPMY-1 cells after the supplement of TGF-beta/Smad pathway inhibitor SD208 group (p < 0.05, p < 0.01). Estradiol 33-35 elastin Homo sapiens 123-130 35441158-6 2022 ERalpha(Ser118) phosphorylation was increased by E2 and TGFalpha in MCF7, by E2 only in LCC1, but by neither in LCC9 cells. Estradiol 77-79 C-C motif chemokine ligand 16 Homo sapiens 88-92 35170266-3 2022 The role of G protein-coupled estrogen receptor (GPR30), which mediates the non-genomic effects of E2, is mostly unexplored. Estradiol 99-101 G protein-coupled estrogen receptor 1 Homo sapiens 49-54 35213517-2 2022 METHODS: REPLENISH evaluated oral estradiol/progesterone (E2/P4) for the treatment of moderate to severe vasomotor symptoms (VMS) in postmenopausal women with a uterus. Estradiol 34-43 cystatin 12, pseudogene Homo sapiens 58-63 35222529-9 2022 Moreover, miR-183 inhibited the synthesis of estradiol in GCs and promoted the synthesis of progesterone. Estradiol 45-54 microRNA 183 Sus scrofa 10-17 35130539-0 2022 Melatonin inhibits 17beta-estradiol-induced epithelial-mesenchymal transition in endometrial adenocarcinoma cells via upregulating Numb expression. Estradiol 19-35 NUMB endocytic adaptor protein Homo sapiens 131-135 35130539-16 2022 CONCLUSIONS: Melatonin blocked 17beta-estradiol-induced cell growth and EMT in endometrial cancer cells via upregulating Numb expression. Estradiol 31-47 NUMB endocytic adaptor protein Homo sapiens 121-125 34953135-4 2022 Estradiol (E2) increases the expression of kisspeptin in Kiss1 AVPV/PeN neurons but decreases its expression in Kiss1 ARH neurons. Estradiol 0-9 KiSS-1 metastasis suppressor Homo sapiens 57-62 34953135-4 2022 Estradiol (E2) increases the expression of kisspeptin in Kiss1 AVPV/PeN neurons but decreases its expression in Kiss1 ARH neurons. Estradiol 0-9 KiSS-1 metastasis suppressor Homo sapiens 112-117 34953135-4 2022 Estradiol (E2) increases the expression of kisspeptin in Kiss1 AVPV/PeN neurons but decreases its expression in Kiss1 ARH neurons. Estradiol 11-13 KiSS-1 metastasis suppressor Homo sapiens 57-62 34953135-4 2022 Estradiol (E2) increases the expression of kisspeptin in Kiss1 AVPV/PeN neurons but decreases its expression in Kiss1 ARH neurons. Estradiol 11-13 KiSS-1 metastasis suppressor Homo sapiens 112-117 34953135-5 2022 Also, Kiss1 ARH neurons co-express glutamate and Kiss1 AVPV/PeN neurons co-express GABA, both of which are upregulated by E2 in females. Estradiol 122-124 KiSS-1 metastasis suppressor Homo sapiens 6-11 34953135-5 2022 Also, Kiss1 ARH neurons co-express glutamate and Kiss1 AVPV/PeN neurons co-express GABA, both of which are upregulated by E2 in females. Estradiol 122-124 KiSS-1 metastasis suppressor Homo sapiens 49-54 35175493-7 2022 The obtained results illustrated that the differentiation medium supplemented with T-E2 increased not only the ALP enzyme activity and the content of calcium but also the osteogenic-related gene and protein expressions on the 14th day. Estradiol 85-87 ATHS Homo sapiens 111-114 35404886-2 2022 Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2). Estradiol 62-64 lipocalin 2 Homo sapiens 262-266 35102146-7 2022 Estradiol induced Fpr2 expression, which protected hepatocytes and the liver from damage. Estradiol 0-9 formyl peptide receptor 2 Mus musculus 18-22 35061800-5 2022 Autodock vina was applied to make molecular docking between CPT or estradiol and GPER. Estradiol 67-76 G protein-coupled estrogen receptor 1 Homo sapiens 81-85 35107859-7 2022 In all spontaneous ovulators, the core endocrine signal is a rise in estradiol secretion from the maturing follicle(s), with the site of estrogen positive feedback being the rostral periventricular kisspeptin neurons in rodents and neurons in the MBH of sheep and primates. Estradiol 69-78 metastasis-suppressor KiSS-1 Ovis aries 198-208 35141003-6 2022 We demonstrate that E2/E2-stimulated ER-alpha can augment BRCA1 mediated high fidelity repairs like HRR (Homologous Recombination Repair) and BER (Base Excision Repair) in breast cancer cells. Estradiol 20-22 BRCA1 DNA repair associated Homo sapiens 58-63 35141003-6 2022 We demonstrate that E2/E2-stimulated ER-alpha can augment BRCA1 mediated high fidelity repairs like HRR (Homologous Recombination Repair) and BER (Base Excision Repair) in breast cancer cells. Estradiol 23-25 BRCA1 DNA repair associated Homo sapiens 58-63 35055130-0 2022 Chemerin Affects P4 and E2 Synthesis in the Porcine Endometrium during Early Pregnancy. Estradiol 24-26 retinoic acid receptor responder 2 Homo sapiens 0-8 35055130-5 2022 Chemerin stimulated E2 production on days 10 to 11 of pregnancy. Estradiol 20-22 retinoic acid receptor responder 2 Homo sapiens 0-8 35055130-10 2022 The obtained results indicate that chemerin affected P4 and E2 synthesis through the Erk1/2 and Akt signalling pathways. Estradiol 60-62 retinoic acid receptor responder 2 Homo sapiens 35-43 35018885-0 2022 Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells. Estradiol 27-36 paired box 2 Homo sapiens 70-74 35057469-0 2022 Effects of 2-Methoxyestradiol, a Main Metabolite of Estradiol on Hepatic ABCA1 Expression in HepG2 Cells. Estradiol 52-61 ATP binding cassette subfamily A member 1 Homo sapiens 73-78 35054909-3 2022 Cytochrome P450 1B1 (CYP1B1) is an oxidative enzyme influencing the neuroinflammatory response by creating inflammatory mediators and metabolizing neuroprotective 17beta-estradiol and progesterone. Estradiol 163-179 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 0-19 35054909-3 2022 Cytochrome P450 1B1 (CYP1B1) is an oxidative enzyme influencing the neuroinflammatory response by creating inflammatory mediators and metabolizing neuroprotective 17beta-estradiol and progesterone. Estradiol 163-179 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 21-27 35633575-9 2022 Our results demonstrated that low doses of 17beta-oestradiol (E2), Ral and Ent had positive effects on the expression of differentiated chondrocyte markers such as COL2A1, ACAN and SNORC whereas high dose of these compounds inhibited their effects. Estradiol 43-60 aggrecan Homo sapiens 172-176 35633575-9 2022 Our results demonstrated that low doses of 17beta-oestradiol (E2), Ral and Ent had positive effects on the expression of differentiated chondrocyte markers such as COL2A1, ACAN and SNORC whereas high dose of these compounds inhibited their effects. Estradiol 62-64 aggrecan Homo sapiens 172-176 35370268-4 2022 beta-Estradiol 3-glucuronidation, which is catalyzed mainly by UGT1A1, was inhibited by 99 and 76% in the presence of 0.1 mg/mL EC1.5-P- and FH-P-SWCNTs in human liver microsomes, respectively. Estradiol 0-14 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 63-69 35370268-5 2022 The observed decrease of free UGT1A1 protein in the enzyme reaction mixture suggests a higher interaction with SWCNTs, and indicates the inhibition of beta-estradiol 3-glucuronidation. Estradiol 151-165 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 30-36 35119676-5 2022 However, over the last decade, the G protein-coupled estrogen receptor (GPER/GPR30) has become recognized as a mediator of rapid as well as transcriptional actions of E2, employing both in vitro and in vivo approaches. Estradiol 167-169 G protein-coupled estrogen receptor 1 Mus musculus 72-76 35119676-5 2022 However, over the last decade, the G protein-coupled estrogen receptor (GPER/GPR30) has become recognized as a mediator of rapid as well as transcriptional actions of E2, employing both in vitro and in vivo approaches. Estradiol 167-169 G protein-coupled estrogen receptor 1 Mus musculus 77-82 35119676-7 2022 Murine genetic knockout (KO) models and pharmacological tools (agonists and antagonists) represent important approaches to understand the mechanisms of E2 action in physiology and disease via GPER. Estradiol 152-154 G protein-coupled estrogen receptor 1 Mus musculus 192-196 2478646-2 1989 However, only Sprague-Dawley rats exhibit an estrogen regulated increase in the number of cells expressing immunoreactive CD4 and Ia, suggesting that the differential responsiveness to the effects of estradiol between the two strains of rats may be genetically controlled. Estradiol 200-209 Cd4 molecule Rattus norvegicus 122-125 2811369-3 1989 The apparent Kis were found to be 34.86 microM for 2-methoxyestradiol and 18.65 microM for the methoxyestrone, with the apparent Km for the substrate estradiol in these essays of 3.21 microM. Estradiol 60-69 U2AF homology motif kinase 1 Rattus norvegicus 13-16 2790033-5 1989 Intracellular mrp/plf mRNA levels were increased by 17 beta-estradiol and reduced by dexamethasone. Estradiol 55-69 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 14-17 2474437-4 1989 Several findings indicate that estradiol enhances cholesterol transport and availability to the P450scc rather than affects the expression of this enzyme: 1) the difference in mitochondrial progestagen synthesis induced by estradiol was obliterated by the presence of 25-hydroxycholesterol; 2) immunoblotting of P450scc indicated no stimulatory effect of estradiol on the amount of enzyme; and 3) levels of P450scc mRNA were not increased by estradiol. Estradiol 31-40 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 96-103 2474437-4 1989 Several findings indicate that estradiol enhances cholesterol transport and availability to the P450scc rather than affects the expression of this enzyme: 1) the difference in mitochondrial progestagen synthesis induced by estradiol was obliterated by the presence of 25-hydroxycholesterol; 2) immunoblotting of P450scc indicated no stimulatory effect of estradiol on the amount of enzyme; and 3) levels of P450scc mRNA were not increased by estradiol. Estradiol 31-40 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 312-319 2474437-4 1989 Several findings indicate that estradiol enhances cholesterol transport and availability to the P450scc rather than affects the expression of this enzyme: 1) the difference in mitochondrial progestagen synthesis induced by estradiol was obliterated by the presence of 25-hydroxycholesterol; 2) immunoblotting of P450scc indicated no stimulatory effect of estradiol on the amount of enzyme; and 3) levels of P450scc mRNA were not increased by estradiol. Estradiol 31-40 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 312-319 2474437-4 1989 Several findings indicate that estradiol enhances cholesterol transport and availability to the P450scc rather than affects the expression of this enzyme: 1) the difference in mitochondrial progestagen synthesis induced by estradiol was obliterated by the presence of 25-hydroxycholesterol; 2) immunoblotting of P450scc indicated no stimulatory effect of estradiol on the amount of enzyme; and 3) levels of P450scc mRNA were not increased by estradiol. Estradiol 223-232 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 96-103 2474437-4 1989 Several findings indicate that estradiol enhances cholesterol transport and availability to the P450scc rather than affects the expression of this enzyme: 1) the difference in mitochondrial progestagen synthesis induced by estradiol was obliterated by the presence of 25-hydroxycholesterol; 2) immunoblotting of P450scc indicated no stimulatory effect of estradiol on the amount of enzyme; and 3) levels of P450scc mRNA were not increased by estradiol. Estradiol 223-232 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 96-103 2769689-7 1989 By contrast, the 2-arylindenes with a C-3 ethyl substituent appear to bind with the pendant C-2 ring, mimicking the A-ring of estradiol (pendant/A mode), as hydroxyl substitution in this ring elevates binding relative to the C-6 hydroxy analogues. Estradiol 126-135 complement C3 Homo sapiens 38-41 2476588-0 1989 Effect of estradiol on pancreatic amylase and cholecystokinin binding in ovariectomized guinea pigs. Estradiol 10-19 cholecystokinin Cavia porcellus 46-61 2500332-5 1989 At confluence, a single exposure to 17 beta-estradiol stimulates a marked transitory rise in tPA activity in the extracellular and cell-associated compartments; the peak increases were at 48 h for medium activity and 24-48 h for cell-associated activity. Estradiol 36-53 chromosome 20 open reading frame 181 Homo sapiens 93-96 2721439-6 1989 In the ovariectomized adult rat there was also a bimodal pattern of ERn 1 and 13-14 h after the injection of 20 micrograms/kg estradiol. Estradiol 126-135 endoplasmic reticulum to nucleus signaling 1 Rattus norvegicus 68-73 2744414-0 1989 Gonadotropin-stimulated estradiol production in small ovarian follicles of the hen is suppressed by physiological concentrations of prolactin in vitro. Estradiol 24-33 prolactin Gallus gallus 132-141 2715754-6 1989 Specificity of the androgen receptor was assessed by displacement analysis; DMNT, 5 alpha-dihydrotestosterone, testosterone and 3 alpha-androstanediol were efficient competitors for the androgen-binding site, while oestradiol-17 beta, progesterone and dexamethasone exhibited very little, if any, competitive potency. Estradiol 215-233 androgen receptor Mesocricetus auratus 19-36 2502049-3 1989 This method measures, with a standard luminometer, the reduced NAD produced and accumulated by the reaction of two dehydrogenase enzymes: the estradiol dehydrogenase for direct assay of estrogens (estrone + estradiol), the glucose-6-phosphate dehydrogenase for gonadotrophin determination. Estradiol 142-151 glucose-6-phosphate dehydrogenase Homo sapiens 223-256 2626019-1 1989 In vitro treatment with 30 nM 17 beta-estradiol stimulated the induction of mRNA for the brain type isozyme of creatine kinase BB (CKBB) and stimulated glucose metabolism in perifused uteri from 27-29-day-old rats. Estradiol 30-47 creatine kinase B Rattus norvegicus 111-129 2626019-1 1989 In vitro treatment with 30 nM 17 beta-estradiol stimulated the induction of mRNA for the brain type isozyme of creatine kinase BB (CKBB) and stimulated glucose metabolism in perifused uteri from 27-29-day-old rats. Estradiol 30-47 creatine kinase B Rattus norvegicus 131-135 2626019-2 1989 The perifusion conditions maintained the normal NMR spectrum of high energy phosphates for at least 24 h. This technique permitted the demonstration that perifused rat uteri stimulated by 17 beta-estradiol show increased mRNA for creatine kinase BB, 1 h after estrogen addition. Estradiol 191-205 creatine kinase B Rattus norvegicus 230-248 2626019-4 1989 injection of 5 micrograms 17 beta-estradiol; the maximal increase is seen at 2-4 h. Experiments utilizing actinomycin D (4 micrograms/ml) for inhibition of RNA synthesis showed that CKB mRNA from both untreated and estradiol stimulated uteri had a similar half-life, of approximately 2 h, indicating that CKB mRNA is transcriptionally regulated. Estradiol 29-43 creatine kinase B Rattus norvegicus 182-185 2626019-4 1989 injection of 5 micrograms 17 beta-estradiol; the maximal increase is seen at 2-4 h. Experiments utilizing actinomycin D (4 micrograms/ml) for inhibition of RNA synthesis showed that CKB mRNA from both untreated and estradiol stimulated uteri had a similar half-life, of approximately 2 h, indicating that CKB mRNA is transcriptionally regulated. Estradiol 34-43 creatine kinase B Rattus norvegicus 182-185 3197943-5 1988 The presence of E2 enhanced (P less than 0.05) the magnitude of the VIP-induced PRL release by cultures of cells from laying hens and diminished (P less than 0.05) the magnitude of this release in cultures of cells from immature hens. Estradiol 16-18 vasoactive intestinal peptide Gallus gallus 68-71 3196968-4 1988 The high estrone secretion and the decreasing levels of 17 beta-estradiol and testosterone in the ovaries of 70 to 125 day fetuses suggest an inhibition of 17 beta-hydroxysteroid dehydrogenase activity. Estradiol 56-73 hydroxysteroid 17-beta dehydrogenase 7 Bos taurus 156-192 3402385-6 1988 Treatment of epithelial and stromal cells for 4 days with 10 nM estradiol led to a 2- to 6-fold increase in progesterone receptor concentration. Estradiol 64-73 progesterone receptor Mus musculus 108-129 3383775-2 1988 We now have analyzed the qualitative and quantitative effects of antiestrogens (tamoxifen and LY117018) on the induction of USP-1 biosynthesis when administered alone or combined with 17 beta-estradiol (E2). Estradiol 184-201 ubiquitin specific peptidase 1 Rattus norvegicus 124-129 2452093-8 1988 In a separate experiment to test the hypothesis that estradiol enhances the release of cholecystokinin from terminals in the mediobasal hypothalamus, this region was dissected from ovariectomized and ovariectomized estrogen-primed rats and superfused with estradiol-17 beta. Estradiol 53-62 cholecystokinin Rattus norvegicus 87-102 2452093-9 1988 Indeed, exposure of the tissue to estradiol-17 beta was observed to enhance the K+-stimulated release of cholecystokinin from a mediobasal hypothalamic block in vitro. Estradiol 34-51 cholecystokinin Rattus norvegicus 105-120 3382028-0 1988 Androgen receptor-deficient Tfm cells in the mosaic epididymis of sex-reversed mice heterozygous for Tfm: an autoradiographic study with [3H]-dihydrotestosterone and [3H]-estradiol. Estradiol 171-180 androgen receptor Mus musculus 0-17 3126035-13 1988 The other is related to the physiology of the system, which involves the simultaneous decrease in LH immunoreactivity and the PR induction in gonadotrophs by estradiol. Estradiol 158-167 progesterone receptor Gallus gallus 126-128 3343247-1 1988 Administration of estradiol-17 beta to male Xenopus laevis induces the hepatic mRNA coding for the serum retinol binding protein (RBP) approximately 10-fold, both in vivo and in primary liver cultures. Estradiol 18-35 retinol binding protein 4 L homeolog Xenopus laevis 99-128 3343247-1 1988 Administration of estradiol-17 beta to male Xenopus laevis induces the hepatic mRNA coding for the serum retinol binding protein (RBP) approximately 10-fold, both in vivo and in primary liver cultures. Estradiol 18-35 SURP and G-patch domain containing 1 L homeolog Xenopus laevis 130-133 3127403-0 1988 Inhibition of imidazole-induced tyrosinase activity by estradiol and estriol in cultured B16/C3 melanoma cells. Estradiol 55-64 tyrosinase Homo sapiens 32-42 3356300-3 1988 This ovariectomy-induced increase in glucocorticoid receptor mRNA content of the intermediate lobe, which was confirmed by in situ hybridization experiments, could be reversed by 17 beta-estradiol administration. Estradiol 179-196 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 37-60 16911-0 1977 Effects of estradiol and nicotinamide adenine dinucleotide phosphate on rate of degradation of uterine glucose-6-phosphate dehydrogenase. Estradiol 11-20 glucose-6-phosphate dehydrogenase Homo sapiens 103-136 300331-4 1977 The occurrence of CSF in the uteri of spayed mice treated with oestradiol did not require DNA synthesis. Estradiol 63-73 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 18-21 576510-1 1977 Effects of estradiol, progesterone, cortisol, thrombophlebitis and typhoid vaccine on the synthesis and catabolism of antithrombin III (AT) in dogs were studied, using I-125-labeled AT (I-125-AT) as a tracer. Estradiol 11-20 serpin family C member 1 Canis lupus familiaris 118-134 913699-4 1977 The mass spectrum showed molecular ions at m/e 342, 416 and 504 which correspond to the TMSi derivatives of Estrone (E-1), Estradiol (E-2) and Estriol (E-3) respectively. Estradiol 123-132 cystatin 12, pseudogene Homo sapiens 134-137 181303-2 1976 Estradiol increased the specific activities of the hepatic lipogenic enzymes, ATP citrate lyase and malate dehydrogenase (decarboxylating) (NADP), but had no effects on the activities of the glycolytic, gluconeogenic and amino acid metabolising enzymes except for pyruvate kinase and glutamate dehydrogenase which were reduced in activity in both experiments. Estradiol 0-9 ATP citrate lyase Homo sapiens 78-95 181303-2 1976 Estradiol increased the specific activities of the hepatic lipogenic enzymes, ATP citrate lyase and malate dehydrogenase (decarboxylating) (NADP), but had no effects on the activities of the glycolytic, gluconeogenic and amino acid metabolising enzymes except for pyruvate kinase and glutamate dehydrogenase which were reduced in activity in both experiments. Estradiol 0-9 malic enzyme 1 Homo sapiens 100-120 179788-10 1976 For the interaction of estradiol with the androgen receptor, the Ki is 8-9 X 10(-9)M. The decrease in the number of DHT binding sites in the brain of tfm/y male-female mice without a concomitant decrease in estradiol binding sites, and the different specificities of the two sites, point to the existence of distinct androgen and estrogen receptor molecules in mouse brain cytosol. Estradiol 23-32 androgen receptor Mus musculus 42-59 179788-10 1976 For the interaction of estradiol with the androgen receptor, the Ki is 8-9 X 10(-9)M. The decrease in the number of DHT binding sites in the brain of tfm/y male-female mice without a concomitant decrease in estradiol binding sites, and the different specificities of the two sites, point to the existence of distinct androgen and estrogen receptor molecules in mouse brain cytosol. Estradiol 207-216 androgen receptor Mus musculus 42-59 170158-12 1975 Other modifiers of cAMP which were effective included prostaglandins E1, E2, and F2alpha (2 times 10(-6) M) and papaverine (1 muM). Estradiol 73-75 antimicrobial protein CAP18 Oryctolagus cuniculus 19-23 169348-0 1975 Protein kinases activated by cAMP in the genital tract of spayed mice treated with oestradiol-17beta. Estradiol 83-100 cathelicidin antimicrobial peptide Mus musculus 29-33 169348-1 1975 The cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37), has been studied in the vaginal epithelium, vaginal stroma, endometrium, and whole uterus of spayed mice treated with oestradiol-17 beta, and in the vaginal epithelium and uterus of spayed mice. Estradiol 199-217 cathelicidin antimicrobial peptide Mus musculus 4-8 165190-2 1975 The temperature-activated 4 to 5 S EBP transformation is found to be highly reproducible without loss of [3H]estradiol-binding activity in a buffer containing an excess of [3H]estradiol, 40 mM Tris, 1 mM dithiothreitol, and 1 M urea at pH 7.4. Estradiol 109-118 EBP cholestenol delta-isomerase Homo sapiens 35-38 4217708-0 1974 [Proceedings: Thyroxine binding globulin (TBG) and estradiol in the maternal system and fetus: the effect of estradiol on TBG]. Estradiol 109-118 serpin family A member 7 Homo sapiens 14-40 4217708-0 1974 [Proceedings: Thyroxine binding globulin (TBG) and estradiol in the maternal system and fetus: the effect of estradiol on TBG]. Estradiol 109-118 serpin family A member 7 Homo sapiens 122-125 4682876-0 1973 A delayed antagonistic effect of progesterone on estradiol induced increases in uterine glucose-6-phosphate dehydrogenase. Estradiol 49-58 glucose-6-phosphate dehydrogenase Homo sapiens 88-121 33868470-0 2021 Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway. Estradiol 22-24 G protein-coupled estrogen receptor 1 Homo sapiens 14-18 33868470-0 2021 Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway. Estradiol 22-24 CD151 molecule (Raph blood group) Homo sapiens 121-126 33868470-5 2021 However, the exact molecular mechanism of miR-124/CD151 action in 17beta-estradiol (E2)-treated breast cancer cells remains unknown. Estradiol 66-82 CD151 molecule (Raph blood group) Homo sapiens 50-55 33868470-5 2021 However, the exact molecular mechanism of miR-124/CD151 action in 17beta-estradiol (E2)-treated breast cancer cells remains unknown. Estradiol 84-86 CD151 molecule (Raph blood group) Homo sapiens 50-55 33868470-6 2021 Thus, the present study aimed to investigate miR-124 and CD151 expression levels in MCF-7 cells treated with E2 via reverse transcription-quantitative PCR and western blot analyses. Estradiol 109-111 CD151 molecule (Raph blood group) Homo sapiens 57-62 33868470-10 2021 The results demonstrated that E2 downregulated miR-124 expression, while upregulating G protein -coupled estrogen receptor (GPER) expression in MCF-7 cells. Estradiol 30-32 G protein-coupled estrogen receptor 1 Homo sapiens 86-122 33868470-10 2021 The results demonstrated that E2 downregulated miR-124 expression, while upregulating G protein -coupled estrogen receptor (GPER) expression in MCF-7 cells. Estradiol 30-32 G protein-coupled estrogen receptor 1 Homo sapiens 124-128 33868470-11 2021 Following treatment with the GPER antagonist, G15, miR-124 expression was significantly enhanced and E2-induced proliferation, invasion and migration of MCF-7 cells were notably inhibited. Estradiol 101-103 G protein-coupled estrogen receptor 1 Homo sapiens 29-33 33868470-13 2021 CD151 silencing remarkably suppressed the proliferation, invasion and migration of E2-induced MCF-7 cells. Estradiol 83-85 CD151 molecule (Raph blood group) Homo sapiens 0-5 33868470-14 2021 Taken together, these results suggest that upregulation of GPER expression induced by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway. Estradiol 86-88 G protein-coupled estrogen receptor 1 Homo sapiens 59-63 33868470-14 2021 Taken together, these results suggest that upregulation of GPER expression induced by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway. Estradiol 86-88 CD151 molecule (Raph blood group) Homo sapiens 185-190 33991616-6 2021 Mechanistically, cotreatment with obesity-related factors (estradiol, insulin and leptin) promoted nuclear translocation of ACLY through Akt-mediated phosphorylation of ACLY at Ser455. Estradiol 59-68 ATP citrate lyase Homo sapiens 124-128 33991616-6 2021 Mechanistically, cotreatment with obesity-related factors (estradiol, insulin and leptin) promoted nuclear translocation of ACLY through Akt-mediated phosphorylation of ACLY at Ser455. Estradiol 59-68 ATP citrate lyase Homo sapiens 169-173 33845412-7 2021 In addition to enhanced androstenedione and testosterone production, estradiol stimulation was also based on the marked increase in abundance of mRNA transcript of steroidogenic enzymes [Star (Steroidogenic Acute Regulatory Protein), Cyp11a1, Cyp17a1, and hsd3b1 (3beta-hydroxysteroid dehydrogenase)], as well as abundances of StAR and CYP11A1 protein. Estradiol 69-78 steroidogenic acute regulatory protein, mitochondrial Capra hircus 187-191 33845412-7 2021 In addition to enhanced androstenedione and testosterone production, estradiol stimulation was also based on the marked increase in abundance of mRNA transcript of steroidogenic enzymes [Star (Steroidogenic Acute Regulatory Protein), Cyp11a1, Cyp17a1, and hsd3b1 (3beta-hydroxysteroid dehydrogenase)], as well as abundances of StAR and CYP11A1 protein. Estradiol 69-78 steroidogenic acute regulatory protein, mitochondrial Capra hircus 193-231 33845412-7 2021 In addition to enhanced androstenedione and testosterone production, estradiol stimulation was also based on the marked increase in abundance of mRNA transcript of steroidogenic enzymes [Star (Steroidogenic Acute Regulatory Protein), Cyp11a1, Cyp17a1, and hsd3b1 (3beta-hydroxysteroid dehydrogenase)], as well as abundances of StAR and CYP11A1 protein. Estradiol 69-78 cytochrome P450 family 17 subfamily A member 1A Capra hircus 243-250 33845412-7 2021 In addition to enhanced androstenedione and testosterone production, estradiol stimulation was also based on the marked increase in abundance of mRNA transcript of steroidogenic enzymes [Star (Steroidogenic Acute Regulatory Protein), Cyp11a1, Cyp17a1, and hsd3b1 (3beta-hydroxysteroid dehydrogenase)], as well as abundances of StAR and CYP11A1 protein. Estradiol 69-78 steroidogenic acute regulatory protein, mitochondrial Capra hircus 327-331 33747172-5 2021 These results provide novel insight into the molecular basis of PSD, and suggest the potential involvement of CREB/BDNF/TrkB signaling in E2-mediated improvement of PSD in rats. Estradiol 138-140 brain-derived neurotrophic factor Rattus norvegicus 115-119 33231812-8 2021 Rostral and middle segment SF1 protein was inhibited by estradiol-independent mechanisms in hypoglycemic males, but increased by estradiol-reliant mechanisms in female. Estradiol 56-65 nuclear receptor subfamily 5, group A, member 1 Rattus norvegicus 27-30 33231812-8 2021 Rostral and middle segment SF1 protein was inhibited by estradiol-independent mechanisms in hypoglycemic males, but increased by estradiol-reliant mechanisms in female. Estradiol 129-138 nuclear receptor subfamily 5, group A, member 1 Rattus norvegicus 27-30 33923905-7 2021 The classic ERs have been acknowledged to function in mediating estrogen effects on glucose metabolism, but 17beta-estradiol also rapidly promotes endothelial glycolysis by increasing glucose transporter 1 (GLUT1) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) levels through GPER-dependent mechanisms. Estradiol 108-124 solute carrier family 2 member 1 Homo sapiens 184-205 33923905-7 2021 The classic ERs have been acknowledged to function in mediating estrogen effects on glucose metabolism, but 17beta-estradiol also rapidly promotes endothelial glycolysis by increasing glucose transporter 1 (GLUT1) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) levels through GPER-dependent mechanisms. Estradiol 108-124 solute carrier family 2 member 1 Homo sapiens 207-212 33923905-7 2021 The classic ERs have been acknowledged to function in mediating estrogen effects on glucose metabolism, but 17beta-estradiol also rapidly promotes endothelial glycolysis by increasing glucose transporter 1 (GLUT1) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) levels through GPER-dependent mechanisms. Estradiol 108-124 G protein-coupled estrogen receptor 1 Homo sapiens 296-300 33924212-2 2021 NGB remarkably exerts its function upon upregulation by NGB inducers, such as 17beta-estradiol (E2) and H2O2. Estradiol 78-94 neuroglobin Homo sapiens 0-3 33924212-2 2021 NGB remarkably exerts its function upon upregulation by NGB inducers, such as 17beta-estradiol (E2) and H2O2. Estradiol 78-94 neuroglobin Homo sapiens 56-59 33924212-2 2021 NGB remarkably exerts its function upon upregulation by NGB inducers, such as 17beta-estradiol (E2) and H2O2. Estradiol 96-98 neuroglobin Homo sapiens 0-3 33924212-2 2021 NGB remarkably exerts its function upon upregulation by NGB inducers, such as 17beta-estradiol (E2) and H2O2. Estradiol 96-98 neuroglobin Homo sapiens 56-59 33878091-7 2021 We observed a significant positive association (P < 0.004) between menopause PRS and E2 level 2 years before menopause and a nominal association (P < 0.05) 2 years after menopause in Japanese women. Estradiol 85-87 PRS Homo sapiens 77-80 33606519-7 2021 This study, for the first time, reports the molecules like cyclosporine, calcitriol, and estradiol as candidate drugs with the binding ability to the host proteases, TMPRSS2, and cathepsin B/L. Estradiol 89-98 cathepsin B Homo sapiens 179-190 33376146-5 2021 Formation of the M1-glucuronide by human liver microsomes from UGT1A1-genotyped donors was significantly correlated with UGT1A1 activity, as measured by 17beta-estradiol 3-glucuronidation (R2 = 0.90). Estradiol 153-169 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 63-69 33376146-5 2021 Formation of the M1-glucuronide by human liver microsomes from UGT1A1-genotyped donors was significantly correlated with UGT1A1 activity, as measured by 17beta-estradiol 3-glucuronidation (R2 = 0.90). Estradiol 153-169 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 121-127 33549631-10 2021 TPT can additionally inhibit activities of UGT1A1 and -1A10 in estradiol-3-O-glucuronidation, with IC50 values of a few micro-molars. Estradiol 63-72 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 43-59 33559208-5 2021 The luteinizing hormone (LH), estradiol-17beta (E2), and LH + E2 treatments significantly increased GHR and IGF1 mRNA expression in cultured BOECs. Estradiol 30-46 growth hormone receptor Bos taurus 100-103 33559208-5 2021 The luteinizing hormone (LH), estradiol-17beta (E2), and LH + E2 treatments significantly increased GHR and IGF1 mRNA expression in cultured BOECs. Estradiol 48-50 growth hormone receptor Bos taurus 100-103 33559208-5 2021 The luteinizing hormone (LH), estradiol-17beta (E2), and LH + E2 treatments significantly increased GHR and IGF1 mRNA expression in cultured BOECs. Estradiol 62-64 growth hormone receptor Bos taurus 100-103 33352471-5 2021 Although dorsal hippocampal E2 infusion increased levels of phospho-TrkB and mature BDNF (mBDNF) in the dorsal hippocampus within 4-6 h, E2-induced increases in hippocampal mBDNF expression were not required for hippocampal TrkB activation and were not inhibited by TrkB antagonism. Estradiol 137-139 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 224-228 33352471-5 2021 Although dorsal hippocampal E2 infusion increased levels of phospho-TrkB and mature BDNF (mBDNF) in the dorsal hippocampus within 4-6 h, E2-induced increases in hippocampal mBDNF expression were not required for hippocampal TrkB activation and were not inhibited by TrkB antagonism. Estradiol 137-139 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 224-228 33352471-7 2021 Together these results provide the first direct evidence that E2 modulation of hippocampal TrkB signaling is required for its beneficial effects on memory consolidation and provide additional characterization of the ways in which TrkB/BDNF signaling is regulated by E2 in the hippocampus. Estradiol 62-64 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 91-95 33352471-7 2021 Together these results provide the first direct evidence that E2 modulation of hippocampal TrkB signaling is required for its beneficial effects on memory consolidation and provide additional characterization of the ways in which TrkB/BDNF signaling is regulated by E2 in the hippocampus. Estradiol 62-64 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 230-234 33352471-7 2021 Together these results provide the first direct evidence that E2 modulation of hippocampal TrkB signaling is required for its beneficial effects on memory consolidation and provide additional characterization of the ways in which TrkB/BDNF signaling is regulated by E2 in the hippocampus. Estradiol 266-268 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 91-95 33352471-7 2021 Together these results provide the first direct evidence that E2 modulation of hippocampal TrkB signaling is required for its beneficial effects on memory consolidation and provide additional characterization of the ways in which TrkB/BDNF signaling is regulated by E2 in the hippocampus. Estradiol 266-268 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 230-234 33428588-7 2021 We also found that estradiol treatment in prepubertal mice increased Edn2 expression in the ovary (p=0.030), suggesting that impaired steroidogenesis may be involved in the HFD-induced dysregulation of ovarian Edn2. Estradiol 19-28 endothelin 2 Mus musculus 69-73 33428588-7 2021 We also found that estradiol treatment in prepubertal mice increased Edn2 expression in the ovary (p=0.030), suggesting that impaired steroidogenesis may be involved in the HFD-induced dysregulation of ovarian Edn2. Estradiol 19-28 endothelin 2 Mus musculus 210-214 33640015-7 2021 To identify the necessary cell signaling proteins in E2-induced TGFbeta1 and TGFbeta2 transcription, human dermal fibroblasts were pre-treated with an inhibitor of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway, U0126. Estradiol 53-55 transforming growth factor beta 2 Homo sapiens 77-85 33290273-8 2021 E2 augmented Treg expression of Foxp3, CD25 and GATA3, an effect that required ERb, and not ERa signaling. Estradiol 0-2 interleukin 2 receptor, alpha chain Mus musculus 39-43 33585202-4 2020 Additionally, in estrogen target cells and tissues, estradiol increases RIZ2 expression level with concurrent increase of cell proliferation and survival. Estradiol 52-61 PR/SET domain 2 Homo sapiens 72-76 33574796-5 2020 In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30. Estradiol 35-51 G protein-coupled estrogen receptor 1 Homo sapiens 320-324 33574796-5 2020 In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30. Estradiol 35-51 G protein-coupled estrogen receptor 1 Homo sapiens 325-330 33574796-5 2020 In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30. Estradiol 53-55 G protein-coupled estrogen receptor 1 Homo sapiens 320-324 33574796-5 2020 In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30. Estradiol 53-55 G protein-coupled estrogen receptor 1 Homo sapiens 325-330 33413673-12 2021 Estradiol levels positively correlated with change in mRS in both women (r = 0.38, p = 0.02) and men (r = 0.3, p = 0.04). Estradiol 0-9 sterile alpha motif domain containing 11 Mus musculus 54-57 33413673-13 2021 CONCLUSIONS: Estradiol levels correlated with functional outcomes (change in mRS) in both men and women, at least in the acute phase (24 h) of stroke. Estradiol 13-22 sterile alpha motif domain containing 11 Mus musculus 77-80 32985706-7 2021 NDV-D90 promoted apoptosis via the intrinsic signaling pathway in BT549 cells (ER-negative cells), possibly by impairing E2-mediated GPER expression. Estradiol 121-123 G protein-coupled estrogen receptor 1 Homo sapiens 133-137 33315175-6 2021 IL-4 production and GATA-3 expression levels slightly increased when asthmatic PBMCs were treated with E2 (p < 0.01), P4 (p < 0.01), or E2 + P4 (p < 0.001) compared to the untreated cells. Estradiol 103-105 GATA binding protein 3 Homo sapiens 20-26 33098822-11 2021 In high-dose-treated mice, decreased serum levels of estradiol, progesterone and increased testosterone along with downregulated endometrial expression of ERalpha and PR suggest the deficiency of steroid hormones and their respective receptors. Estradiol 53-62 histocompatibility 40 Mus musculus 3-7 33098822-13 2021 Therefore, in high-dose-treated mice, decreased maternal estradiol and progesterone levels and their receptors during implantation hindered signaling to LIF and Hoxa-10, resulting in pragmatic implantation failure. Estradiol 57-66 histocompatibility 40 Mus musculus 14-18 33384715-0 2020 HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol. Estradiol 84-93 homeo box A5 Rattus norvegicus 0-5 33384715-5 2020 Biochemical studies show that estradiol (E2) regulates HOXA5 gene expression in cultured breast cancer cells in vitro. Estradiol 30-39 homeo box A5 Rattus norvegicus 55-60 33384715-5 2020 Biochemical studies show that estradiol (E2) regulates HOXA5 gene expression in cultured breast cancer cells in vitro. Estradiol 41-43 homeo box A5 Rattus norvegicus 55-60 33384715-7 2020 E2-induced HOXA5 expression is coordinated by ERs. Estradiol 0-2 homeo box A5 Rattus norvegicus 11-16 33384715-8 2020 Knockdown of either ERalpha or ERbeta downregulated E2-induced HOXA5 expression. Estradiol 52-54 homeo box A5 Rattus norvegicus 63-68 33384715-10 2020 In summary, our studies demonstrate that HOXA5 is overexpressed in breast cancer and is transcriptionally regulated via estradiol in breast cancer cells. Estradiol 120-129 homeo box A5 Rattus norvegicus 41-46 33028712-9 2020 Finally, the enhanced vaginal Th1 TRM cells present in E2-treated mice were found to be modulated through an IL-17-mediated pathway, as E2-treated IL-17A deficient mice had impaired establishment of Th1 TRM cells. Estradiol 136-138 interleukin 17A Mus musculus 109-114 33028712-9 2020 Finally, the enhanced vaginal Th1 TRM cells present in E2-treated mice were found to be modulated through an IL-17-mediated pathway, as E2-treated IL-17A deficient mice had impaired establishment of Th1 TRM cells. Estradiol 136-138 interleukin 17A Mus musculus 147-153 33068422-2 2020 Here, we observed that both estradiol and the GPER-specific agonist G1 rapidly induced cAMP production in cumulus cells, leading to transient stimulation of phosphorylated cAMP response element binding protein (CREB), which was conducive to the transcription of epidermal growth factor (EGF)-like factors, amphiregulin, epiregulin, and betacellulin. Estradiol 28-37 amphiregulin Homo sapiens 306-318 33068422-3 2020 Inhibition of GPER by G15 significantly reduced estradiol-induced CREB phosphorylation and EGF-like factor gene expression. Estradiol 48-57 G protein-coupled estrogen receptor 1 Homo sapiens 14-18 33068422-3 2020 Inhibition of GPER by G15 significantly reduced estradiol-induced CREB phosphorylation and EGF-like factor gene expression. Estradiol 48-57 cAMP responsive element binding protein 1 Homo sapiens 66-70 33068422-4 2020 Consistently, the silencing of GPER expression in cultured cumulus cells abrogated the estradiol-induced CREB phosphorylation and EGF-like factor transcription. Estradiol 87-96 G protein-coupled estrogen receptor 1 Homo sapiens 31-35 33068422-4 2020 Consistently, the silencing of GPER expression in cultured cumulus cells abrogated the estradiol-induced CREB phosphorylation and EGF-like factor transcription. Estradiol 87-96 cAMP responsive element binding protein 1 Homo sapiens 105-109 32873626-5 2020 We have found that estradiol-dependent Sin1 expression is transcriptionally modulated by GPER1 as well as ERalpha. Estradiol 19-28 G protein-coupled estrogen receptor 1 Mus musculus 89-94 32735789-10 2020 Optimization of expression and buffer conditions increased the proportion of E2-binding competent CD81 protein. Estradiol 77-79 CD81 molecule Homo sapiens 98-102 32855171-11 2020 In conclusion, male and female human islets convert T into DHT and E2 via the intracrine activities of SRD5A1 and aromatase. Estradiol 67-69 steroid 5 alpha-reductase 1 Homo sapiens 103-109 32798220-0 2020 A CRH Receptor Type 1 Agonist Increases GABA Transmission to GnRH Neurons in a Circulating-Estradiol-Dependent Manner. Estradiol 91-100 corticotropin releasing hormone Mus musculus 2-5 32798220-3 2020 In brain slices from unstressed controls, CRH has opposite, estradiol-dependent effects on GnRH neuron firing depending on the CRH receptor activated; activating CRHR-1 stimulates whereas activating CRHR-2 suppresses activity. Estradiol 60-69 corticotropin releasing hormone Mus musculus 42-45 32798220-13 2020 These results suggest CRH increases GnRH neuron activity in an estradiol-dependent manner in part by activating GABAergic afferents. Estradiol 63-72 corticotropin releasing hormone Mus musculus 22-25 32779215-3 2020 Therefore, the aim of this study was to investigate the effect of E2 binding enzyme UBC9 on the expression of SUMO-1 protein during the in vitro maturation of porcine oocytes and embryo development after in vitro fertilization. Estradiol 66-68 SUMO-conjugating enzyme UBC9 Sus scrofa 84-88 33193095-12 2020 Conclusion: Together, these results indicate that chronic GPER1 activation with its agonists E2 or G1 treatment protects H9c2 cardiomyoblasts against oxidative stress-induced cell death and increases cell viability by preserving mitochondrial structure and function as well as delaying the opening of mPTP. Estradiol 93-95 G protein-coupled estrogen receptor 1 Mus musculus 58-63 33083624-9 2020 Both DHEA and estradiol treatments increased the expression of BDNF, phosphorylation of ERK and CREB, and ERbeta, but not that of ERalpha in the hippocampus of the ovariectomized rats. Estradiol 14-23 brain-derived neurotrophic factor Rattus norvegicus 63-67 32628929-6 2020 Moreover, beta-estradiol increased ERalpha, ERbeta, GPR30 and ABCG5 protein expression, and decreased the levels of NPC1L1 and SR-B1 in the jejunum of ovariectomized mice. Estradiol 10-24 G protein-coupled estrogen receptor 1 Mus musculus 52-57 32628929-6 2020 Moreover, beta-estradiol increased ERalpha, ERbeta, GPR30 and ABCG5 protein expression, and decreased the levels of NPC1L1 and SR-B1 in the jejunum of ovariectomized mice. Estradiol 10-24 NPC1 like intracellular cholesterol transporter 1 Mus musculus 116-122 32628929-8 2020 ERbeta or GPR30 inhibition decreased the protective effect of beta-estradiol on cholesterol accumulation, tight junctions, and inflammation in cholesterol incubated Caco-2 cells, while silencing both ERbeta and GPR30 completely eliminated the protective effect of beta-estradiol. Estradiol 62-76 G protein-coupled estrogen receptor 1 Homo sapiens 10-15 32628929-8 2020 ERbeta or GPR30 inhibition decreased the protective effect of beta-estradiol on cholesterol accumulation, tight junctions, and inflammation in cholesterol incubated Caco-2 cells, while silencing both ERbeta and GPR30 completely eliminated the protective effect of beta-estradiol. Estradiol 264-278 G protein-coupled estrogen receptor 1 Homo sapiens 10-15 32628929-10 2020 Our results provide evidence that beta-estradiol regulates intestinal function via ERbeta and GPR30 mediated PI3K/AKT signaling activation to alleviate postmenopausal dyslipidemia. Estradiol 34-48 G protein-coupled estrogen receptor 1 Homo sapiens 94-99 32513838-2 2020 Estradiol-induced cellular changes are mediated through the activation of nuclear and extranuclear estrogen receptors (ERs), which include ERalpha, ERbeta, and the G-protein coupled receptor, GPER1. Estradiol 0-9 G protein-coupled estrogen receptor 1 Homo sapiens 192-197 32947858-3 2020 Recent structural and functional analyses have highlighted the role of the CD81 receptor binding site on E2, which overlaps with those neutralization epitopes within E2 that have been structurally characterized to date. Estradiol 105-107 CD81 molecule Homo sapiens 75-79 32947858-3 2020 Recent structural and functional analyses have highlighted the role of the CD81 receptor binding site on E2, which overlaps with those neutralization epitopes within E2 that have been structurally characterized to date. Estradiol 166-168 CD81 molecule Homo sapiens 75-79 32817249-13 2020 The current study advances our understanding of this process by demonstrating that neuron-derived 17beta-estradiol (E2) is neuroprotective and critical for induction of reactive astrocytes and their ability to produce astrocyte-derived neurotrophic factors, BDNF and IGF-1, and the glutamate transporter, GLT-1 after ischemic brain damage. Estradiol 98-114 solute carrier family 1 (glial high affinity glutamate transporter), member 2 Mus musculus 305-310 32817249-13 2020 The current study advances our understanding of this process by demonstrating that neuron-derived 17beta-estradiol (E2) is neuroprotective and critical for induction of reactive astrocytes and their ability to produce astrocyte-derived neurotrophic factors, BDNF and IGF-1, and the glutamate transporter, GLT-1 after ischemic brain damage. Estradiol 116-118 solute carrier family 1 (glial high affinity glutamate transporter), member 2 Mus musculus 305-310 33041800-2 2020 We aimed to demonstrate whether and how the SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury. Estradiol 49-51 ubiquitin-conjugating enzyme E2I Mus musculus 71-75 32915867-10 2020 The Apela mRNA levels were significantly up-regulated in primary hepatocytes treated with 17beta-estradiol (p <= 0.05), and could be effectively inhibited by estrogen receptor antagonists MPP, ICI 182780 and tamoxifen. Estradiol 90-106 apelin receptor early endogenous ligand Gallus gallus 4-9 32228192-10 2020 The results revealed that EV administration induced complex EH with focal atypia and loss of PTEN expression by the histological examination. Estradiol 26-28 phosphatase and tensin homolog Rattus norvegicus 93-97 32592200-11 2020 Gene expression of IL10 and FABP4 increased in E2 + EM. Estradiol 47-51 fatty acid-binding protein, adipocyte Sus scrofa 28-33 32667746-9 2020 Furthermore, Western blot assay showed that E2 treatment could increase the expression and activity of beta-catenin, snail and N-cadherin and reduce the expression of E-cadherin. Estradiol 44-46 cadherin 2 Homo sapiens 127-137 32535690-10 2020 Co-administration of E2 with Ago synergistically decreased NF-kB P65 expression and pro-inflammatory cytokines, and increased BDNF levels. Estradiol 21-23 brain-derived neurotrophic factor Rattus norvegicus 126-130 32345867-9 2020 17beta-Estradiol treatment was associated with 2-fold increase in eNOS protein (p<0.0001) and gene (p=0.0009) expression, with no differences in endothelin-1 expression. Estradiol 0-16 nitric oxide synthase 3 Rattus norvegicus 66-70 32801905-3 2020 We knocked down stromal FGF18 expression in a co-culture system and aimed to explore the contribution of E2-induced stromal FGF18 to the proliferation and invasion of EC cells. Estradiol 105-107 fibroblast growth factor 18 Homo sapiens 24-29 32801905-3 2020 We knocked down stromal FGF18 expression in a co-culture system and aimed to explore the contribution of E2-induced stromal FGF18 to the proliferation and invasion of EC cells. Estradiol 105-107 fibroblast growth factor 18 Homo sapiens 124-129 32339349-6 2020 In this research, the result of ALP activity assay, calcium content and Real-time RT-PCR assay and also all tests of differentiation staining have shown that 17-beta estradiol has been recognized as an enhancing factor of osteogenic differentiation. Estradiol 158-175 ATHS Homo sapiens 32-35 32410477-0 2020 17beta-Estradiol improves osteoblastic cell function through the Sirt1/NF-kappaB/MMP-8 pathway. Estradiol 0-16 matrix metallopeptidase 8 Mus musculus 81-86 32623449-6 2020 Analysis of differential gene expression between unexposed ArKO samples and samples from animals exhibiting the ability to mount an E2-induced uterine growth response (WT or E2 exposed ArKO) revealed activation of EZH2 and HAND2 signaling and inhibition of GLI1 responses. Estradiol 132-134 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 214-218 32623449-6 2020 Analysis of differential gene expression between unexposed ArKO samples and samples from animals exhibiting the ability to mount an E2-induced uterine growth response (WT or E2 exposed ArKO) revealed activation of EZH2 and HAND2 signaling and inhibition of GLI1 responses. Estradiol 174-176 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 214-218 32665530-5 2020 RESULTS: Univariate analysis showed that RBP4 values correlated with age, low-density lipoprotein-cholesterol and estradiol levels. Estradiol 114-123 retinol binding protein 4 Homo sapiens 41-45 32665530-7 2020 RBP4 differed according to PWV, using the median PWV value as cut-off (RBP4, PWV <=8.1 vs >8.1 m/s: 10.09 +- 2.05 vs 10.85 +- 1.91 ng/mL, analysis of covariance P value 0.014 adjusted for age, menopausal age, estradiol, pulse pressure). Estradiol 209-218 retinol binding protein 4 Homo sapiens 0-4 32793229-0 2020 17beta-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB. Estradiol 0-16 avian reticuloendotheliosis viral (v-rel) oncogene related B Mus musculus 109-113 32793229-14 2020 Mechanistically, we found that E2 inhibited the nuclear translocation of RelB, which is a member of non-canonical pathway of NFkappaB and contributes to macrophage polarization to change the intensity of trained immunity. Estradiol 31-33 avian reticuloendotheliosis viral (v-rel) oncogene related B Mus musculus 73-77 32422398-13 2020 This provides strong support to the concept that these Kiss1 neurons are pivotal to the long-recognized "seasonal switch in the ability of E2 to exert negative feedback", which drives seasonal breeding. Estradiol 139-141 metastasis-suppressor KiSS-1 Ovis aries 55-60 32668270-7 2020 In human EECs, 10 nM DELAQ decreased estradiol-induced expression of growth-regulated estrogen receptor binding 1 (GREB1) by 1.8-fold. Estradiol 37-46 growth regulating estrogen receptor binding 1 Homo sapiens 69-113 32668270-7 2020 In human EECs, 10 nM DELAQ decreased estradiol-induced expression of growth-regulated estrogen receptor binding 1 (GREB1) by 1.8-fold. Estradiol 37-46 growth regulating estrogen receptor binding 1 Homo sapiens 115-120 32444497-9 2020 Using a luciferase reporter assay, we found that the upstream region of the human IL15 gene up-regulates reporter gene activities in response to estradiol and a progestin representative (medroxyprogesterone) in ESCs. Estradiol 145-154 interleukin 15 Homo sapiens 82-86 32645874-0 2020 Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats. Estradiol 17-19 NLR family, CARD domain containing 4 Rattus norvegicus 90-95 32645874-7 2020 E2 or P selectively mitigated the stroke-induced increase of AIM2 and NLRC4. Estradiol 0-2 NLR family, CARD domain containing 4 Rattus norvegicus 70-75 32378708-11 2020 Whilst estradiol appears to be the primary regulator of BDNF expression, we also identified reports describing binding sites for glucocorticoid and myocyte enhancer factor-2, a calcium-response element through activation of an N-methyl-D-aspartate (NMDA) receptor, and aryl hydrocarbon receptor nuclear transporter protein-4 (ARNT) response elements in promoter regions of the BDNF gene. Estradiol 7-16 brain derived neurotrophic factor Homo sapiens 56-60 32487604-0 2020 Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30. Estradiol 73-82 G protein-coupled estrogen receptor 1 Homo sapiens 87-92 32487604-2 2020 The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation of membrane-tethered pro-heparin-binding EGF-like growth factor and the MAPK/ERK pathway. Estradiol 119-128 G protein-coupled estrogen receptor 1 Homo sapiens 44-49 32487604-6 2020 RESULTS: Many similarities on the effect of CCL18 on the already known estradiol-activated signaling pathway via the G protein-coupled estrogen receptor GPR30 were identified. Estradiol 71-80 G protein-coupled estrogen receptor 1 Homo sapiens 153-158 32487604-11 2020 This is a rather unexpected result, because the estrogen estradiol and CCL18 both activate GPR30. Estradiol 57-66 G protein-coupled estrogen receptor 1 Homo sapiens 91-96 32487604-18 2020 CCL18 and estradiol may not lead to the same signaling pathway after activating GPR30. Estradiol 10-19 G protein-coupled estrogen receptor 1 Homo sapiens 80-85 32328699-4 2020 As the induction of RACK1 expression can be blocked by the antagonist G15, induced by the agonist G1 and by the non-cell permeable 17beta-estradiol conjugated with BSA, a role of GPER (previously named GPR30) activation in estrogen-induced RACK1 expression could be demonstrated. Estradiol 131-147 receptor for activated C kinase 1 Homo sapiens 20-25 32017324-0 2020 17-beta-estradiol increases macrophage activity through activation of the GPER estrogen receptor and improves the response of female mice to Cryptococcus gattii. Estradiol 0-17 G protein-coupled estrogen receptor 1 Mus musculus 74-78 32432511-7 2020 The present study tests the hypothesis that estradiol induces estrous cycle relevant differences in MSN electrophysiology. Estradiol 44-53 moesin Rattus norvegicus 100-103 32432511-9 2020 Estradiol replacement decreased MSN excitability by modulating properties such as resting membrane potential, input resistance in both the linear and rectified ranges, and rheobase, compared to vehicle treated females. Estradiol 0-9 moesin Rattus norvegicus 32-35 32432511-12 2020 These data are the first to demonstrate that an estrous cycle relevant estradiol exposure modulates MSN electrophysiology, providing evidence of the fundamental neuroendocrine mechanisms regulating the AcbC. Estradiol 71-80 moesin Rattus norvegicus 100-103 32438750-19 2020 The enzyme levels of StAR and 3beta-HSD were highly correlated with E2 levels. Estradiol 68-70 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 30-39 32439217-9 2022 We found positive correlation between serum E2 levels and both biomolecules (TREK-1; P = 0.018, AQP5; P = 0.016). Estradiol 44-46 aquaporin 5 Rattus norvegicus 96-100 32241910-5 2020 We determined crystal structures of Drosophila melanogaster Nobo (DmNobo) complexed with glutathione and 17beta-estradiol, a DmNobo inhibitor. Estradiol 105-121 Glutathione S transferase E14 Drosophila melanogaster 60-64 32365144-7 2020 Our results suggested that exogenous gonadotropin administration leads to a significant decrease in the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9 and Mitopld genes, which are critically important in the piRNA pathway, and the changes in the expression levels of Tdrd9, Tdrd1 and Mael may be associated with plasma E2 levels. Estradiol 321-323 piwi like RNA-mediated gene silencing 2 Homo sapiens 122-126 32365144-7 2020 Our results suggested that exogenous gonadotropin administration leads to a significant decrease in the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9 and Mitopld genes, which are critically important in the piRNA pathway, and the changes in the expression levels of Tdrd9, Tdrd1 and Mael may be associated with plasma E2 levels. Estradiol 321-323 phospholipase D family member 6 Homo sapiens 157-164 31982399-9 2020 In addition, based on LC-MS/MS analyses, 17beta-HSD12 did not convert any substrates other than 17OHP, including DHP, adrenosterone, androstenedione, estrone, testosterone, 11-ketotestosterone, and estradiol-17beta. Estradiol 198-207 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 41-53 31996328-14 2020 In summary, our results suggest that miR-326 upregulate CREB and CREB may activate C/EBP-beta and later inhibited the transcription of CYP19A1 and decreased estradiol-17b production. Estradiol 157-166 cAMP responsive element binding protein 1 Homo sapiens 56-60 31996328-14 2020 In summary, our results suggest that miR-326 upregulate CREB and CREB may activate C/EBP-beta and later inhibited the transcription of CYP19A1 and decreased estradiol-17b production. Estradiol 157-166 cAMP responsive element binding protein 1 Homo sapiens 65-69 32045601-6 2020 Estradiol increased the hepatic expression of miR-33 and inhibited that of miR-34a and miR-21, leading to adjusting the gene expression and the protein level of their targets, sterol regulatory element-binding proteins-1c (SREBP-1c), fatty acid synthase (FASN), high mobility group (HMG) Box Transcription Factor 1 (HBP1) and Sirtuin 1 (SIRT1), receptively. Estradiol 0-9 microRNA 21 Rattus norvegicus 87-93 31784877-0 2020 Cantilever Nanobiosensor Functionalized with Tyrosinase for Detection of Estrone and beta-estradiol in Water. Estradiol 85-99 tyrosinase Homo sapiens 45-55 31784877-1 2020 This work aimed to develop cantilever nanobiosensor functionalized with tyrosinase enzyme to detect 17beta-estradiol and estrone hormones. Estradiol 100-116 tyrosinase Homo sapiens 72-82 32057953-6 2020 Interestingly, there was an upregulation in gene expression of tropomyosin receptor kinase B (Trkb) in the ventral hippocampus, as well as brain-derived neurotrophic factor (Bdnf) and postsynaptic density protein-95 (Psd-95) in the amygdala of OVX-Ttc9a-/- mice compared to those treated with estradiol. Estradiol 293-302 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 63-92 32057953-6 2020 Interestingly, there was an upregulation in gene expression of tropomyosin receptor kinase B (Trkb) in the ventral hippocampus, as well as brain-derived neurotrophic factor (Bdnf) and postsynaptic density protein-95 (Psd-95) in the amygdala of OVX-Ttc9a-/- mice compared to those treated with estradiol. Estradiol 293-302 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 94-98 32148125-0 2020 Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice. Estradiol 37-46 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 8-14 32148125-0 2020 Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice. Estradiol 37-46 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 16-35 32148125-1 2020 Previously, we showed that peripheral administration of 2-ME (2-methoxyestradiol), a CYP1B1 (cytochrome P450 1B1)-catechol-O-methyltransferase (COMT) generated metabolite of E2 (17beta-Estradiol), protects against angiotensin II-induced hypertension in female mice. Estradiol 178-194 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 85-91 32148125-1 2020 Previously, we showed that peripheral administration of 2-ME (2-methoxyestradiol), a CYP1B1 (cytochrome P450 1B1)-catechol-O-methyltransferase (COMT) generated metabolite of E2 (17beta-Estradiol), protects against angiotensin II-induced hypertension in female mice. Estradiol 178-194 catechol-O-methyltransferase Mus musculus 144-148 31913228-1 2020 OBJECTIVE: The aim of the study was to evaluate the effect of a single-capsule 17beta-estradiol/progesterone (E2/P4), TX-001HR, on endometrial safety, to report on amenorrhea and bleeding patterns of users, and to identify predictors of amenorrhea. Estradiol 79-95 cystatin 12, pseudogene Homo sapiens 110-115 32291422-2 2020 METHODS: Real-time polymerase chain reaction analysis of SIRT-1 expression over 48 hours (h) was performed in HAECs treated with various concentrations of dehydroepiandrostendione (DHEA), androstenedione and testosterone (androgens), estrone (E1), estradiol (E2), and estriol (E3) (estrogens) to investigate the dose-dependency of time courses. Estradiol 248-257 sirtuin 1 Homo sapiens 57-63 32291422-2 2020 METHODS: Real-time polymerase chain reaction analysis of SIRT-1 expression over 48 hours (h) was performed in HAECs treated with various concentrations of dehydroepiandrostendione (DHEA), androstenedione and testosterone (androgens), estrone (E1), estradiol (E2), and estriol (E3) (estrogens) to investigate the dose-dependency of time courses. Estradiol 259-261 sirtuin 1 Homo sapiens 57-63 32291422-6 2020 Estrone and E2, but not E3, caused a marked dose-dependent increase in SIRT1 expression from 10 to 20 mug/ml. Estradiol 12-14 sirtuin 1 Homo sapiens 71-76 32291422-7 2020 Treatment with 20 mM or 40 mM glucose medium did not significantly inhibit E1- and E3-induced SIRT1 expression in control medium; however, both high glucose mediums significantly emphasized E2-induced SIRT1 expression in control medium (p=0.007, p=0.005). Estradiol 190-192 sirtuin 1 Homo sapiens 201-206 32050020-0 2020 Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity. Estradiol 0-9 toll/interleukin-1 receptor-like protein Arabidopsis thaliana 70-73 32300484-3 2020 The aim of this study is to investigate the impact of BMI and serum estradiol level on expression of PAX-2, H-TERT, P16, Ki-67, and P53 in studied ETM in reference to benign endometrium and EC. Estradiol 68-77 paired box 2 Homo sapiens 101-106 31698960-7 2020 This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2. Estradiol 114-116 G protein-coupled estrogen receptor 1 Homo sapiens 45-50 32077170-6 2020 These effects were inhibited by treatment with either 17beta-oestradiol (E2 ) (10 nmol L-1 ) or G1 (100 nmol L-1 ), the selective agonist of the G protein-coupled oestrogen receptor (GPER1). Estradiol 54-71 G protein-coupled estrogen receptor 1 Homo sapiens 183-188 32006244-11 2020 Although the basal expression of Kiss-1 was increased by E2, letrozole did not modulate Kiss-1 expression in mHypoA-50 cells. Estradiol 57-59 KiSS-1 metastasis-suppressor Mus musculus 33-39 32120850-6 2020 17beta-estradiol could significantly inhibit the expression of gga-miR-221-5p but promote the expression of ELOVL6 and SQLE genes. Estradiol 0-16 microRNA 221 Gallus gallus 63-74 32120850-8 2020 Meanwhile, 17beta-estradiol could repress the expression of gga-miR-221-5p but increase the expression of ELOVL6 and SQLE, therefore promoting the synthesis of intracellular triglyceride and cholesterol levels in the liver of egg-laying chicken. Estradiol 11-27 microRNA 221 Gallus gallus 60-71 32028879-0 2020 Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol. Estradiol 73-83 keratin 86 Mus musculus 0-10 32028879-4 2020 Using a hyperoestrogen mouse model established in a previous study, we found abnormal oestradiol (E2) levels during pre-implantation could trigger high expression of Krt86 in the uterine epithelium. Estradiol 86-96 keratin 86 Mus musculus 166-171 31760088-0 2020 DHEAS prevents pro-metastatic and proliferative effects of 17ss-estradiol on MCF-7 breast cancer cells. Estradiol 64-73 sulfotransferase family 2A member 1 Homo sapiens 0-5 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 claudin 1 Homo sapiens 143-152 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 matrix metallopeptidase 9 Homo sapiens 154-180 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 matrix metallopeptidase 9 Homo sapiens 182-186 31760088-5 2020 In contrast, treatment with DHEAS did not stimulate these responses but prevented all of the actions of 17ss-estradiol, and as a consequence cell migration and invasion were completely inhibited. Estradiol 109-118 sulfotransferase family 2A member 1 Homo sapiens 28-33 32096196-10 2020 The cell migration rate, the number of migrating cells, and expression levels of MMP2 and MMP9 were significantly decreased in E2/TAM-treated hypoxia group, compared with those in E2-treated hypoxia group. Estradiol 127-129 matrix metallopeptidase 9 Homo sapiens 90-94 32096196-11 2020 CONCLUSIONS: In summary, E2 can promote the migration of vascular smooth muscle cells and induce varicose veins of the lower extremities, which may be related to the promotion of MMP2 and MMP9 expression through the classical pathway of ER. Estradiol 25-27 matrix metallopeptidase 9 Homo sapiens 188-192 31675171-5 2020 The results showed that the increased proportion of slow subdiffusion of GM1 -binding cholera toxin B-subunit (CT-B) is accompanied with an increased liquid-ordered domain during the beta-estradiol-induced fusion of lipid rafts. Estradiol 183-197 phosphate cytidylyltransferase 1B, choline Homo sapiens 86-109 31675171-5 2020 The results showed that the increased proportion of slow subdiffusion of GM1 -binding cholera toxin B-subunit (CT-B) is accompanied with an increased liquid-ordered domain during the beta-estradiol-induced fusion of lipid rafts. Estradiol 183-197 phosphate cytidylyltransferase 1B, choline Homo sapiens 111-115 31671405-6 2020 Functional studies on primary cultures of sorted fetal Kiss1-GFP cells revealed a significant negative effect of estradiol treatment on neurite outgrowth on the fourth day of culture in the female group specifically. Estradiol 113-122 KiSS-1 metastasis-suppressor Mus musculus 55-60 31671405-7 2020 We conclude that the ARC Kiss1 cell population is already sexually differentiated at E16.5 and that its morphogenetic development may be particularly vulnerable to estradiol exposure at this early developmental time. Estradiol 164-173 KiSS-1 metastasis-suppressor Mus musculus 25-30 31841397-9 2020 E2 treatment resulted in 40 DEG with Krt5, Krt15, Olig3, Crabp1, and Serpinb7 upregulated in Ezh2cKO compared with control mice. Estradiol 0-2 keratin 15 Mus musculus 43-48 31841397-9 2020 E2 treatment resulted in 40 DEG with Krt5, Krt15, Olig3, Crabp1, and Serpinb7 upregulated in Ezh2cKO compared with control mice. Estradiol 0-2 cellular retinoic acid binding protein I Mus musculus 57-63 32064044-7 2020 Studies using human keratinocytes revealed that both estradiol and FA induced REDD1 mRNA/protein expression, and cooperated when they were combined at low doses. Estradiol 53-62 DNA damage inducible transcript 4 Homo sapiens 78-83 30849411-9 2020 We found that E2 inhibited the expression of MT1 and MT2 in cultured oviduct cells. Estradiol 14-16 metallothionein-2 Ovis aries 53-56 31711705-6 2020 In pGCs, 10 ng/mL AMH significantly decreased the FSH-stimulated effect on FSHR and CYP19A1 expression and estradiol production. Estradiol 107-116 muellerian-inhibiting factor Sus scrofa 18-21 31454071-9 2020 Furthermore, decreased ZNF217 expression was supposed to inhibit estradiol synthesis, which further promoted cyclooxygenase 2 and PGE2 synthesis. Estradiol 65-74 zinc finger protein 217 Homo sapiens 23-29 32879215-0 2020 beta-Estradiol Enhanced Secretion of Lipoprotein Lipase from Mouse Mammary Tumor FM3A Cells. Estradiol 0-14 lipoprotein lipase Mus musculus 37-55 32879215-1 2020 The role of beta-estradiol (E2) in lipoprotein metabolism in mammary tumors is unclear, therefore, we investigated the effect of E2 on the secretion of lipoprotein lipase (LPL) from mouse mammary tumor FM3A cells. Estradiol 129-131 lipoprotein lipase Mus musculus 152-170 32879215-1 2020 The role of beta-estradiol (E2) in lipoprotein metabolism in mammary tumors is unclear, therefore, we investigated the effect of E2 on the secretion of lipoprotein lipase (LPL) from mouse mammary tumor FM3A cells. Estradiol 129-131 lipoprotein lipase Mus musculus 172-175 32879215-2 2020 E2-treated cells increased the secretion of active LPL from FM3A cells in a time- and dose-dependent manner. Estradiol 0-2 lipoprotein lipase Mus musculus 51-54 31678498-6 2020 Meanwhile, our in vitro study found that 17beta-estradiol stimulation resulted in the loss of extracellular matrix, increased expression of TNF-alpha, IL-1, HIF2alpha and its" down-stream OA-related cytokines (MMP-13, VEGF and Col X) in primary condylar chondrocytes via oestrogen receptor beta (ERbeta), which could be reversed by ER antagonist, selective estrogen receptor modulators (SERMs) and HIF2alpha translation inhibitor. Estradiol 41-57 endothelial PAS domain protein 1 Rattus norvegicus 157-166 31678498-6 2020 Meanwhile, our in vitro study found that 17beta-estradiol stimulation resulted in the loss of extracellular matrix, increased expression of TNF-alpha, IL-1, HIF2alpha and its" down-stream OA-related cytokines (MMP-13, VEGF and Col X) in primary condylar chondrocytes via oestrogen receptor beta (ERbeta), which could be reversed by ER antagonist, selective estrogen receptor modulators (SERMs) and HIF2alpha translation inhibitor. Estradiol 41-57 matrix metallopeptidase 13 Rattus norvegicus 188-216 32653508-2 2020 In the present study, the full-length Schizothorax prenanti gdf9 cDNA sequence was isolated and characterized, and its expression pattern in developing gonads and in the gonads of exogenous oestradiol (E2)-fed fish were analysed. Estradiol 190-200 growth differentiation factor 9 Homo sapiens 60-64 32653508-2 2020 In the present study, the full-length Schizothorax prenanti gdf9 cDNA sequence was isolated and characterized, and its expression pattern in developing gonads and in the gonads of exogenous oestradiol (E2)-fed fish were analysed. Estradiol 202-204 growth differentiation factor 9 Homo sapiens 60-64 32653508-6 2020 Furthermore, the gonadal expression of gdf9 induced by exogenous E2 was related to the feeding time and dose. Estradiol 65-67 growth differentiation factor 9 Homo sapiens 39-43 31105126-10 2020 In vitro experiment using human endothelial cells demonstrated that E2 also increased SIRT1 expression and retarded oxidized low density lipoprotein-induced premature senescence, which were also abolished by sirtinol. Estradiol 68-70 sirtuin 1 Homo sapiens 86-91 31602590-5 2020 Semi-quantitative RT-PCR demonstrated significantly increased expression of Esr, Igf1, Igfbp3, Vegfr1, and Vegf, and significantly decreased expression of Mmp9 after co-treatment with estradiol and leptin, indicating a common transcriptional network regulated by the treatments. Estradiol 184-193 FMS-like tyrosine kinase 1 Mus musculus 95-101 31602590-5 2020 Semi-quantitative RT-PCR demonstrated significantly increased expression of Esr, Igf1, Igfbp3, Vegfr1, and Vegf, and significantly decreased expression of Mmp9 after co-treatment with estradiol and leptin, indicating a common transcriptional network regulated by the treatments. Estradiol 184-193 vascular endothelial growth factor A Mus musculus 95-99 31212279-3 2020 Since the anorexigenic hormone 17beta-estradiol (E2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, we hypothesized that E2 would protect against insulin resistance in NPY/AgRP neurons with diet-induced obesity (DIO). Estradiol 31-47 agouti related neuropeptide Homo sapiens 177-181 31212279-3 2020 Since the anorexigenic hormone 17beta-estradiol (E2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, we hypothesized that E2 would protect against insulin resistance in NPY/AgRP neurons with diet-induced obesity (DIO). Estradiol 31-47 agouti related neuropeptide Homo sapiens 264-268 31499120-10 2019 MMP12 co-localized with CD44 on the cell membrane and MMP12 knockdown significantly reduced estradiol-induced PC3 invasion. Estradiol 92-101 CD44 antigen Mus musculus 24-28 31499120-10 2019 MMP12 co-localized with CD44 on the cell membrane and MMP12 knockdown significantly reduced estradiol-induced PC3 invasion. Estradiol 92-101 proprotein convertase subtilisin/kexin type 1 Mus musculus 110-113 31969500-5 2019 After overexpressing TXNIP, the effect of E2 on the learning and memory ability of AD rat model was observed. Estradiol 42-44 thioredoxin interacting protein Rattus norvegicus 21-26 31969500-6 2019 : Results: ROS, TXNIP and apoptosis levels were enhanced in AD cell model, while E2 treatment reduced ROS, TXNIP and apoptosis levels in AD cell model. Estradiol 82-84 thioredoxin interacting protein Rattus norvegicus 108-113 31969500-7 2019 After enhancing TXNIP, E2 treatment reduced ROS and apoptosis levels in AD cell model. Estradiol 23-25 thioredoxin interacting protein Rattus norvegicus 16-21 31969500-8 2019 Similar to the cell experiment, E2 enhanced the learning and memory ability in the AD rat model and inhibited the expression of TXNIP in brain, while TXNIP overexpression attenuated the effect of E2 on learning and memory ability in the AD rats. Estradiol 32-34 thioredoxin interacting protein Rattus norvegicus 128-133 31969500-8 2019 Similar to the cell experiment, E2 enhanced the learning and memory ability in the AD rat model and inhibited the expression of TXNIP in brain, while TXNIP overexpression attenuated the effect of E2 on learning and memory ability in the AD rats. Estradiol 196-198 thioredoxin interacting protein Rattus norvegicus 150-155 31666443-5 2019 The concentration of oviductal E2 was positively correlated with the mRNA expressions of nuclear P4 receptor (PGR) and protein disulfide isomerase family A member 4 (PDIA4), which is related to protein secretion, in the ampulla and with estrogen receptor alpha (ESR1) mRNA expression in the isthmus. Estradiol 31-33 progesterone receptor Bos taurus 110-113 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 190-199 growth regulating estrogen receptor binding 1 Homo sapiens 14-59 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 190-199 growth regulating estrogen receptor binding 1 Homo sapiens 61-66 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 190-199 growth regulating estrogen receptor binding 1 Homo sapiens 223-228 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 201-203 growth regulating estrogen receptor binding 1 Homo sapiens 14-59 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 201-203 growth regulating estrogen receptor binding 1 Homo sapiens 61-66 31744881-3 2019 Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERalpha target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERalpha-activated GREB1 transcription. Estradiol 201-203 growth regulating estrogen receptor binding 1 Homo sapiens 223-228 31744881-5 2019 In the presence of E2, ERalpha bound the GREB1 enhancer and also associated with its promoter, and p300, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL4), and RNA polymerase II were recruited to the GREB1 enhancer and promoter. Estradiol 19-21 growth regulating estrogen receptor binding 1 Homo sapiens 41-46 31744881-5 2019 In the presence of E2, ERalpha bound the GREB1 enhancer and also associated with its promoter, and p300, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL4), and RNA polymerase II were recruited to the GREB1 enhancer and promoter. Estradiol 19-21 growth regulating estrogen receptor binding 1 Homo sapiens 210-215 31746335-6 2019 Accordingly, SIRT1 and its orthologues Sir2 and Sir-2.1 are shown to be veritable nuclear receptor coregulators that classically coactivate the oestrogen receptor in the absence of ligand; coactivation was further increased by 17beta-oestradiol. Estradiol 227-244 sirtuin 1 Homo sapiens 13-18 31746335-6 2019 Accordingly, SIRT1 and its orthologues Sir2 and Sir-2.1 are shown to be veritable nuclear receptor coregulators that classically coactivate the oestrogen receptor in the absence of ligand; coactivation was further increased by 17beta-oestradiol. Estradiol 227-244 sirtuin 1 Homo sapiens 39-43 31862882-4 2019 Furthermore, RNF208 was induced by 17beta-estradiol (E2) treatment in an estrogen receptor alpha (EpsilonRalpha)-dependent manner. Estradiol 35-51 ring finger protein 208 Homo sapiens 13-19 31920512-7 2019 Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry. Estradiol 22-38 G protein-coupled estrogen receptor 1 Homo sapiens 14-18 31920512-7 2019 Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry. Estradiol 22-38 G protein-coupled estrogen receptor 1 Homo sapiens 53-57 31586450-3 2019 Endogenous ligand 17-beta-estradiol (E2), GPER1 agonist (G-1), and E2 with GPER1 antagonist (G-15) or classic estrogen receptor alpha and beta (ERalpha and ERbeta) antagonist tamoxifen (TAM) were subcutaneous administered before NMDA to identify the possible involved receptors. Estradiol 18-35 G protein-coupled estrogen receptor 1 Mus musculus 75-80 31111482-5 2019 Increased levels of CCL5 in the microenvironment of follicles attenuated preantral follicle growth, survival, and estradiol secretion. Estradiol 114-123 C-C motif chemokine ligand 5 Homo sapiens 20-24 31526329-5 2019 Administration of E2 but not P4 caused a significant loss of TMJ collagen and glycosaminoglycans, which was accompanied by amplification of ERalpha and specific increases in MMP9 and MMP13 expression. Estradiol 18-20 matrix metallopeptidase 9 Homo sapiens 174-178 31526329-7 2019 Dose-response experiments showed a greater sensitivity and a higher peak induction of MMP9 and MMP13 in TMJ fibrocartilaginous cells than knee meniscus cells to E2, providing an explanation for the differential responses of these tissues to E2. Estradiol 161-163 matrix metallopeptidase 9 Homo sapiens 86-90 31526329-7 2019 Dose-response experiments showed a greater sensitivity and a higher peak induction of MMP9 and MMP13 in TMJ fibrocartilaginous cells than knee meniscus cells to E2, providing an explanation for the differential responses of these tissues to E2. Estradiol 241-243 matrix metallopeptidase 9 Homo sapiens 86-90 31697961-0 2019 Voluntary exercise and estradiol reverse ovariectomy-induced spatial learning and memory deficits and reduction in hippocampal brain-derived neurotrophic factor in rats. Estradiol 23-32 brain-derived neurotrophic factor Rattus norvegicus 127-160 31628182-1 2019 Activation of the membrane estrogen receptor G-protein-coupled estrogen receptor (GPER) in ovariectomized mice via the GPER agonist G-1 mimics the beneficial effects of 17beta-estradiol (E2) on hippocampal CA1 spine density and memory consolidation, yet the cell-signaling mechanisms mediating these effects remain unclear. Estradiol 169-185 G protein-coupled estrogen receptor 1 Mus musculus 45-80 31628182-1 2019 Activation of the membrane estrogen receptor G-protein-coupled estrogen receptor (GPER) in ovariectomized mice via the GPER agonist G-1 mimics the beneficial effects of 17beta-estradiol (E2) on hippocampal CA1 spine density and memory consolidation, yet the cell-signaling mechanisms mediating these effects remain unclear. Estradiol 169-185 G protein-coupled estrogen receptor 1 Mus musculus 82-86 31628182-1 2019 Activation of the membrane estrogen receptor G-protein-coupled estrogen receptor (GPER) in ovariectomized mice via the GPER agonist G-1 mimics the beneficial effects of 17beta-estradiol (E2) on hippocampal CA1 spine density and memory consolidation, yet the cell-signaling mechanisms mediating these effects remain unclear. Estradiol 169-185 G protein-coupled estrogen receptor 1 Mus musculus 119-123 31628182-8 2019 Collectively, these data demonstrate that GPER-mediated hippocampal spinogenesis and memory consolidation depend on JNK and cofilin signaling, supporting a critical role for actin polymerization in the GPER-induced regulation of hippocampal function in female mice.SIGNIFICANCE STATEMENTEmerging evidence suggests that GPER activation mimics effects of 17beta-estradiol on hippocampal memory consolidation. Estradiol 353-369 G protein-coupled estrogen receptor 1 Mus musculus 42-46 31628182-8 2019 Collectively, these data demonstrate that GPER-mediated hippocampal spinogenesis and memory consolidation depend on JNK and cofilin signaling, supporting a critical role for actin polymerization in the GPER-induced regulation of hippocampal function in female mice.SIGNIFICANCE STATEMENTEmerging evidence suggests that GPER activation mimics effects of 17beta-estradiol on hippocampal memory consolidation. Estradiol 353-369 G protein-coupled estrogen receptor 1 Mus musculus 202-206 31628182-8 2019 Collectively, these data demonstrate that GPER-mediated hippocampal spinogenesis and memory consolidation depend on JNK and cofilin signaling, supporting a critical role for actin polymerization in the GPER-induced regulation of hippocampal function in female mice.SIGNIFICANCE STATEMENTEmerging evidence suggests that GPER activation mimics effects of 17beta-estradiol on hippocampal memory consolidation. Estradiol 353-369 G protein-coupled estrogen receptor 1 Mus musculus 202-206 31628184-0 2019 Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents. Estradiol 0-9 KiSS-1 metastasis-suppressor Mus musculus 95-105 31628184-2 2019 Kisspeptin neurons in the hypothalamic arcuate nucleus help convey homeostatic estradiol feedback to central systems controlling fertility. Estradiol 79-88 KiSS-1 metastasis-suppressor Mus musculus 0-10 31628184-11 2019 These observations support the hypothesis that PSPs in arcuate kisspeptin neurons are regulated by estradiol-sensitive mechanisms including potassium conductances and membrane properties.SIGNIFICANCE STATEMENT Kisspeptin neurons relay estradiol feedback to gonadotropin-releasing hormone neurons, which regulate the reproductive system. Estradiol 99-108 KiSS-1 metastasis-suppressor Mus musculus 63-73 31628184-11 2019 These observations support the hypothesis that PSPs in arcuate kisspeptin neurons are regulated by estradiol-sensitive mechanisms including potassium conductances and membrane properties.SIGNIFICANCE STATEMENT Kisspeptin neurons relay estradiol feedback to gonadotropin-releasing hormone neurons, which regulate the reproductive system. Estradiol 99-108 KiSS-1 metastasis-suppressor Mus musculus 210-220 31628184-11 2019 These observations support the hypothesis that PSPs in arcuate kisspeptin neurons are regulated by estradiol-sensitive mechanisms including potassium conductances and membrane properties.SIGNIFICANCE STATEMENT Kisspeptin neurons relay estradiol feedback to gonadotropin-releasing hormone neurons, which regulate the reproductive system. Estradiol 235-244 KiSS-1 metastasis-suppressor Mus musculus 63-73 31628184-11 2019 These observations support the hypothesis that PSPs in arcuate kisspeptin neurons are regulated by estradiol-sensitive mechanisms including potassium conductances and membrane properties.SIGNIFICANCE STATEMENT Kisspeptin neurons relay estradiol feedback to gonadotropin-releasing hormone neurons, which regulate the reproductive system. Estradiol 235-244 KiSS-1 metastasis-suppressor Mus musculus 210-220 31628184-15 2019 The suppression of both passive and active intrinsic properties by estradiol feedback thus renders arcuate kisspeptin neurons more sensitive to fast synaptic inputs. Estradiol 67-76 KiSS-1 metastasis-suppressor Mus musculus 107-117 31724756-0 2019 Estradiol-17beta inhibits homocysteine mediated damage by promoting H2 S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells. Estradiol 0-16 cystathionine gamma-lyase Homo sapiens 109-112 31787875-13 2019 17beta-estradiol administration was associated with increased expression of ClC-3. Estradiol 0-16 chloride voltage-gated channel 3 Rattus norvegicus 76-81 31787875-14 2019 17beta-estradiol-induced increase in ClC-3 expression was blocked by co-administration of Cltx. Estradiol 0-16 chloride voltage-gated channel 3 Rattus norvegicus 37-42 31787875-16 2019 Patch clamp results suggested that 17beta-estradiol attenuated the excitability of neurons induced by SNI by up-regulating the expression of ClC-3 in the DRG of OVX rats. Estradiol 35-51 chloride voltage-gated channel 3 Rattus norvegicus 141-146 31505456-9 2019 In controls, HLA-G level was independently associated with progesterone and estradiol (beta= 0.44 (0.35;1.27) and -0.44 (-0.94;-0.26) respectively, both p-values = 0.001). Estradiol 76-85 major histocompatibility complex, class I, G Homo sapiens 13-18 31505456-10 2019 In CAH patients, HLA-G level was independently associated with mineralocorticoid supplementation dosage (beta= 0.25 (0.04;0.41), p=0.001) and estradiol (beta= -0.22 (-0.57;-0.02), p<0.001). Estradiol 142-151 major histocompatibility complex, class I, G Homo sapiens 17-22 31505456-12 2019 HLA-G level was positively associated with progesterone and corticosteroid supplementation, and negatively with estradiol. Estradiol 112-121 major histocompatibility complex, class I, G Homo sapiens 0-5 31548121-9 2019 CONCLUSIONS: Oxytocin antagonist reversed the effects of high oestradiol and oxytocin on parameters related to endometrial receptivity in conditions mimicking ovarian stimulation. Estradiol 62-72 oxytocin/neurophysin I prepropeptide Homo sapiens 13-21 31589598-0 2019 The developmental Wnt signaling pathway effector beta-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism. Estradiol 112-121 catenin (cadherin associated protein), beta 1 Mus musculus 49-61 31553790-0 2019 Human chorionic gonadotropin-induced amphiregulin stimulates aromatase expression in human granulosa-lutein cells: a mechanism for estradiol production in the luteal phase. Estradiol 131-140 amphiregulin Homo sapiens 37-49 31553790-2 2019 SUMMARY ANSWER: AREG mediates the hCG-induced up-regulation of aromatase expression and estradiol (E2) production in hGL cells. Estradiol 88-97 amphiregulin Homo sapiens 16-20 31553790-2 2019 SUMMARY ANSWER: AREG mediates the hCG-induced up-regulation of aromatase expression and estradiol (E2) production in hGL cells. Estradiol 99-101 amphiregulin Homo sapiens 16-20 31553790-16 2019 MAIN RESULTS AND THE ROLE OF CHANCE: Treatment of hGL cells with AREG-stimulated aromatase expression and E2 production. Estradiol 106-108 amphiregulin Homo sapiens 65-69 31553790-17 2019 Using pharmacological inhibitors and specific siRNAs, we revealed that AREG-stimulated aromatase expression and E2 production via EGFR-mediated activation of the protein kinase B (AKT) signaling pathway. Estradiol 112-114 amphiregulin Homo sapiens 71-75 31553790-18 2019 In addition, inhibition of EGFR activity and AREG knockdown attenuated hCG-induced up-regulation of aromatase expression and E2 production. Estradiol 125-127 amphiregulin Homo sapiens 45-49 31553790-19 2019 Importantly, the protein levels of AREG in the follicular fluid were positively correlated with the E2 levels in serum after 2 days of oocyte pick-up and in the follicular fluid of IVF patients. Estradiol 100-102 amphiregulin Homo sapiens 35-39 31553790-23 2019 WIDER IMPLICATIONS OF THE FINDINGS: Our results provide the first evidence that hCG-induced AREG contributes to aromatase expression and E2 production in the luteal phase of the menstrual cycle. Estradiol 137-139 amphiregulin Homo sapiens 92-96 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 0-16 notch receptor 4 Homo sapiens 132-138 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 0-16 SRY-box transcription factor 2 Homo sapiens 140-144 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 0-16 Nanog homeobox Homo sapiens 152-157 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 18-20 notch receptor 4 Homo sapiens 132-138 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 18-20 SRY-box transcription factor 2 Homo sapiens 140-144 31387918-6 2019 17beta-Estradiol (E2)-mediated ER activation stabilized the DAXX protein, which was required for repressing stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, and ALDH1A1), and TICs in vitro and in vivo. Estradiol 18-20 Nanog homeobox Homo sapiens 152-157 31310931-10 2019 All four chemicals interfered with estradiol-mediated induction of PGR, NPPC, and GREB1. Estradiol 35-44 natriuretic peptide C Homo sapiens 72-76 31310931-10 2019 All four chemicals interfered with estradiol-mediated induction of PGR, NPPC, and GREB1. Estradiol 35-44 growth regulating estrogen receptor binding 1 Homo sapiens 82-87 31378101-2 2019 We previously reported that hypertension in female growth-restricted offspring that is associated with early reproductive senescence and a shift in the testosterone-to-estradiol ratio at 12 months of age is abolished by AR (androgen receptor) blockade in conjunction with downregulation of renal AT1aR (angiotensin type 1a receptor) mRNA expression. Estradiol 168-177 androgen receptor Rattus norvegicus 220-222 31378101-2 2019 We previously reported that hypertension in female growth-restricted offspring that is associated with early reproductive senescence and a shift in the testosterone-to-estradiol ratio at 12 months of age is abolished by AR (androgen receptor) blockade in conjunction with downregulation of renal AT1aR (angiotensin type 1a receptor) mRNA expression. Estradiol 168-177 androgen receptor Rattus norvegicus 224-241 31401382-0 2019 Estradiol inhibits fMLP-induced neutrophil migration and superoxide production by upregulating MKP-2 and dephosphorylating ERK. Estradiol 0-9 dual specificity phosphatase 4 Homo sapiens 95-100 31201927-10 2019 Due to the increase of CBG synthesis, cortisol levels were increased under oral contraceptives (OC) significantly (p < 0.0001), while OC suppressed progesterone, 17-OHP, androstenedione, and estradiol (p < 0.0001). Estradiol 194-203 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 23-26 31265900-0 2019 Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis. Estradiol 96-105 retinoid X receptor alpha Homo sapiens 0-19 31265900-7 2019 The RXR antagonists HX531 and UVI3003 and the CYP19 inhibitor letrozole abolished the neuroprotection elicited by bexarotene, indicating that estradiol produced by RXR stimulation protects neurons from ischemic insult. Estradiol 142-151 retinoid X receptor alpha Homo sapiens 4-7 31265900-7 2019 The RXR antagonists HX531 and UVI3003 and the CYP19 inhibitor letrozole abolished the neuroprotection elicited by bexarotene, indicating that estradiol produced by RXR stimulation protects neurons from ischemic insult. Estradiol 142-151 retinoid X receptor alpha Homo sapiens 164-167 31265900-11 2019 Taken together, RXR stimulation can protect neurons via enhanced synthesis of estradiol with antioxidative mechanisms. Estradiol 78-87 retinoid X receptor alpha Homo sapiens 16-19 31289138-8 2019 Serum and glucocorticoid-regulated kinase 3 (SGK3) and cAMP-Dependent Protein Kinase Inhibitor beta (PKIB), were confirmed to be regulated by 4AD and shown to be mediated by AR; crucially re-exposure to estradiol suppressed expression of these genes. Estradiol 203-212 serum/glucocorticoid regulated kinase family member 3 Homo sapiens 0-43 31289138-8 2019 Serum and glucocorticoid-regulated kinase 3 (SGK3) and cAMP-Dependent Protein Kinase Inhibitor beta (PKIB), were confirmed to be regulated by 4AD and shown to be mediated by AR; crucially re-exposure to estradiol suppressed expression of these genes. Estradiol 203-212 cAMP-dependent protein kinase inhibitor beta Homo sapiens 55-99 31289138-8 2019 Serum and glucocorticoid-regulated kinase 3 (SGK3) and cAMP-Dependent Protein Kinase Inhibitor beta (PKIB), were confirmed to be regulated by 4AD and shown to be mediated by AR; crucially re-exposure to estradiol suppressed expression of these genes. Estradiol 203-212 cAMP-dependent protein kinase inhibitor beta Homo sapiens 101-105 31404576-1 2019 The GPCR, GPER, mediates many of the rapid, non-genomic actions of 17beta-estradiol in multiple tissues, including the nervous system. Estradiol 67-83 G protein-coupled estrogen receptor 1 Mus musculus 10-14 31352039-0 2019 Bitter taste signaling mediated by Tas2r144 is down-regulated by 17beta-estradiol and progesterone in the rat choroid plexus. Estradiol 65-81 taste receptor, type 2, member 144 Rattus norvegicus 35-43 31203134-0 2019 Estradiol promotes trophoblast viability and invasion by activating SGK1. Estradiol 0-9 serum/glucocorticoid regulated kinase 1 Homo sapiens 68-72 31203134-2 2019 Serum- and glucocorticoid-inducible kinase (SGK1) has been shown to regulate specific cellular targets downstream of E2. Estradiol 117-119 serum/glucocorticoid regulated kinase 1 Homo sapiens 44-48 31203134-3 2019 However, whether and how SGK1 directly mediates the regulatory effects of E2 on trophoblasts functions remain unknown. Estradiol 74-76 serum/glucocorticoid regulated kinase 1 Homo sapiens 25-29 31203134-5 2019 The effect of E2 on SGK1 regulation was assessed using luciferase reporter gene assay and Chromatin Immunoprecipitation assay. Estradiol 14-16 serum/glucocorticoid regulated kinase 1 Homo sapiens 20-24 31203134-6 2019 The mediation of regulatory effects of E2 by SGK1 on trophoblast functions including cell viability, invasion and related signaling molecules such as B cell leukemia/lymphoma 6, E-cadherin, matrix metalloproteinase 2, alpha-ENaC, vascular endothelial growth factor, and the phosphorylation status of FOXO1 and AKT were evaluated in HTR8/SVneo cells transfected with SGK1 knockdown plasmid with/without E2 treatment. Estradiol 39-41 serum/glucocorticoid regulated kinase 1 Homo sapiens 45-49 31203134-8 2019 E2 (10 nM) increased SGK1 promoter activity directly through estrogen receptor. Estradiol 0-2 serum/glucocorticoid regulated kinase 1 Homo sapiens 21-25 31203134-10 2019 SGK1 knockdown abrogated the above responses to E2 treatment. Estradiol 48-50 serum/glucocorticoid regulated kinase 1 Homo sapiens 0-4 31203134-11 2019 CONCLUSIONS: SGK1 mediates the effects of E2 on trophoblast viability and invasion, suggesting that SGK1 acts as a key node in regulating the cross-talk at the feto-maternal interface during the development of placenta and might be a potential therapeutic target for EPL. Estradiol 42-44 serum/glucocorticoid regulated kinase 1 Homo sapiens 13-17 31203134-11 2019 CONCLUSIONS: SGK1 mediates the effects of E2 on trophoblast viability and invasion, suggesting that SGK1 acts as a key node in regulating the cross-talk at the feto-maternal interface during the development of placenta and might be a potential therapeutic target for EPL. Estradiol 42-44 serum/glucocorticoid regulated kinase 1 Homo sapiens 100-104 31507154-0 2019 17beta-estradiol replacement therapy induces eNOS, nNOS and estrogen receptor beta in hypophysectomized rats with inflamed footpads. Estradiol 0-16 nitric oxide synthase 1 Rattus norvegicus 51-55 31507154-10 2019 The higher levels of estradiol-induced eNOS and nNOS ocurred perhaps through the activation of ER beta. Estradiol 21-30 nitric oxide synthase 1 Rattus norvegicus 48-52 31576731-9 2019 Only estradiol decreased inflammation, accompanied by increased levels of eNOS and nNOS and differential expression of ERs alpha and beta in the inflammatory infiltrate. Estradiol 5-14 nitric oxide synthase 1 Rattus norvegicus 83-87 31576731-10 2019 The higher levels of estradiol-induced eNOS and nNOS ocurred perhaps through the activation of ER beta. Estradiol 21-30 nitric oxide synthase 1 Rattus norvegicus 48-52 31314648-11 2019 This is the first demonstration of acute estradiol action on MSN excitatory synapse function. Estradiol 41-50 moesin Rattus norvegicus 61-64 31314648-13 2019 These findings emphasize that sex is a significant biological variable both in MSN sensitivity to estradiol and in pre- and postsynaptic mechanisms of glutamatergic signaling. Estradiol 98-107 moesin Rattus norvegicus 79-82 30458681-3 2019 Because Kiss-1 gene expression in these cells is upregulated by estradiol (E2), mHypoA-50 cells are regarded as a valuable model for the study of Kiss-1-expressing neurons in the AVPV region. Estradiol 64-73 KiSS-1 metastasis-suppressor Mus musculus 8-14 30458681-3 2019 Because Kiss-1 gene expression in these cells is upregulated by estradiol (E2), mHypoA-50 cells are regarded as a valuable model for the study of Kiss-1-expressing neurons in the AVPV region. Estradiol 75-77 KiSS-1 metastasis-suppressor Mus musculus 8-14 30458681-8 2019 In addition, we found that RFRP-3 stimulation increased the expression of corticotropin-releasing hormone, which may be involved in E2-induced positive feedback in mHypoA-50 cells. Estradiol 132-134 corticotropin releasing hormone Mus musculus 74-105 31125757-10 2019 Furthermore, we identified a novel role for GluN2B in mediating the effects of estradiol on generalized fear in female rats. Estradiol 79-88 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 44-50 31253753-8 2019 Existing literature suggests that resilience may be explained by estradiol-mediated transactivation of beta1-integrins and tropomyosin receptor kinase B (trkB). Estradiol 65-74 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 123-152 31253753-8 2019 Existing literature suggests that resilience may be explained by estradiol-mediated transactivation of beta1-integrins and tropomyosin receptor kinase B (trkB). Estradiol 65-74 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 154-158 31430865-6 2019 The results indicate that 17beta-estradiol, by stimulating ERalpha/SIRT1, halts d-gal-induced oxidative stress-mediated JNK/NF-kB overexpression, neuroinflammation and neuronal apoptosis. Estradiol 26-42 mitogen-activated protein kinase 8 Mus musculus 120-123 31399562-0 2019 A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade. Estradiol 34-36 Atg3p Saccharomyces cerevisiae S288C 37-41 31399562-5 2019 We propose that Atg3"s E123IR protects the E2~UBL thioester bond from wayward reactivity toward errant nucleophiles, while Atg8 lipidation cascade enzymes induce E2 active site remodeling through an unprecedented mechanism to drive autophagy. Estradiol 43-45 Atg3p Saccharomyces cerevisiae S288C 16-20 31447779-0 2019 17beta-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet beta Cells Through GPER and Akt/mTOR/GLUT2 Pathway. Estradiol 0-16 mechanistic target of rapamycin kinase Rattus norvegicus 113-117 31447779-1 2019 Aims: To explore the molecular mechanism by which 17beta-estradiol (estrogen 2, E2) regulates glucose transporter 2 (GLUT2) and insulin secretion in islet beta cells through G protein-coupled estrogen receptor (GPER) via Akt/mTOR pathway. Estradiol 50-66 mechanistic target of rapamycin kinase Rattus norvegicus 225-229 31206871-3 2019 We hypothesized that use of a RIA would reveal multiple hypothalamic regions as targets of negative seasonal feedback of estradiol on KP production in sheep. Estradiol 121-130 metastasis-suppressor KiSS-1 Ovis aries 134-136 31206871-11 2019 CONCLUSION: Our RIA results indicate that in addition to the MBH, the POA and AHA appear to be involved in the seasonal negative feedback of estradiol on KP expression. Estradiol 141-150 metastasis-suppressor KiSS-1 Ovis aries 154-156 31167231-2 2019 Meanwhile, kisspeptin in the anteroventral periventricular nucleus (AVPV) region has been implicated in estradiol (E2)-induced GnRH surges. Estradiol 104-113 KiSS-1 metastasis-suppressor Mus musculus 11-21 31304922-4 2019 The expression of PROK 1 mRNA was detected by qPCR after treated with estradiol (E2) or TNF-alpha. Estradiol 70-79 prokineticin 1 Homo sapiens 18-24 30939050-6 2019 Cyp19A1 decreased when Klf4 was overexpressed, and Cyp19A1 and estradiol biosynthesis increased when Klf4 was knocked down. Estradiol 63-72 Kruppel like factor 4 Homo sapiens 101-105 30599794-7 2019 Estradiol could increase 1,25(OH)2D3 and PTH levels and decrease serum ALP level. Estradiol 0-9 PDZ and LIM domain 3 Rattus norvegicus 71-74 30444369-6 2019 One of the most significant roles of ABAD is to maintain the balance of estradiol/estrone in neurons. Estradiol 72-81 hydroxysteroid 17-beta dehydrogenase 10 Homo sapiens 37-41 30807216-8 2019 The addition of VWR to E2-treated OHFFD rats led to AMPK activation and upregulation of peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha and PPARdelta in skeletal muscle along with increased fatty acid oxidation and suppressed fatty acid synthesis in the liver. Estradiol 23-25 peroxisome proliferator-activated receptor gamma Rattus norvegicus 88-136 30807216-8 2019 The addition of VWR to E2-treated OHFFD rats led to AMPK activation and upregulation of peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha and PPARdelta in skeletal muscle along with increased fatty acid oxidation and suppressed fatty acid synthesis in the liver. Estradiol 23-25 peroxisome proliferator-activated receptor gamma Rattus norvegicus 138-147 30151564-10 2019 The serum progesterone and estradiol levels decreased (P < 0.05) with the reduced expressions in the ovarian steroidogenic genes (StAR, P450scc, and 3beta-HSD) (P < 0.05). Estradiol 27-36 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 139-161 30541132-2 2019 OBJECTIVE: Determine GDF9 and BMP15 effects on FSH stimulation of estradiol production in primary human cumulus granulosa cells (GCs). Estradiol 66-75 growth differentiation factor 9 Homo sapiens 21-25 30639544-12 2019 E2 of genotype 3a and CD81 had the strongest interaction. Estradiol 0-2 CD81 molecule Homo sapiens 22-26 30791080-9 2019 Serum BDNF levels were positively and significantly associated with both serum estradiol levels (p=0.0004) and the BMD measured at all sites (all p<0.05). Estradiol 79-88 brain derived neurotrophic factor Homo sapiens 6-10 30791080-12 2019 Thus, serum BDNF levels may be associated with decreased BMD and serve as an indicator of the therapeutic effect of estradiol supplementation in female athletes with osteoporosis. Estradiol 116-125 brain derived neurotrophic factor Homo sapiens 12-16 30807979-0 2019 Estradiol impairs epithelial CXCL1 gradient in the cervix to delay neutrophil transepithelial migration during insemination. Estradiol 0-9 C-X-C motif chemokine ligand 1 Homo sapiens 29-34 30866584-2 2019 By quantitative PCR (qPCR), western blot, immunofluorescence analysis, ELISA and ChIP assays, we demonstrated that 17beta-estradiol (E2) and the G protein estrogen receptor (GPER) agonist G-1 induce the up-regulation and secretion of FGF2 via GPER together with the EGFR/ERK/c-fos/AP-1 signaling cascade in (ER)-negative primary CAFs. Estradiol 115-131 G protein-coupled estrogen receptor 1 Homo sapiens 243-247 30866584-2 2019 By quantitative PCR (qPCR), western blot, immunofluorescence analysis, ELISA and ChIP assays, we demonstrated that 17beta-estradiol (E2) and the G protein estrogen receptor (GPER) agonist G-1 induce the up-regulation and secretion of FGF2 via GPER together with the EGFR/ERK/c-fos/AP-1 signaling cascade in (ER)-negative primary CAFs. Estradiol 115-131 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 275-280 30586196-7 2019 The results showed that NOTCH2 inhibited the synthesis of estradiol, but FILIP1L promoted the synthesis of estradiol. Estradiol 58-67 neurogenic locus notch homolog protein 2 Sus scrofa 24-30 30586196-7 2019 The results showed that NOTCH2 inhibited the synthesis of estradiol, but FILIP1L promoted the synthesis of estradiol. Estradiol 107-116 FILIP1L Sus scrofa 73-80 30543998-8 2019 In the pZP group, but not the reZP group, CD8+ T-cell proliferation showed significant negative correlations to circulating progesterone, oestradiol and anti-Mullerian hormone levels. Estradiol 138-148 CD8a molecule Homo sapiens 42-45 30277497-4 2019 In cultured primary UAEC, treatment with estradiol-17beta (E2beta) stimulated CBS and CTH mRNAs and proteins in a time- and concentration-dependent fashion. Estradiol 41-57 cystathionine gamma-lyase Homo sapiens 86-89 30840299-13 2019 Expression levels of collagen I, collagen III, NOX4, and NF-kappaB in RV of PAH rats were all downregulated by 17-beta estradiol treatment. Estradiol 111-128 NADPH oxidase 4 Rattus norvegicus 47-51 30840299-15 2019 It is suggested that 17-beta estradiol exerts its protective role in PAH by inhibiting NOX4-mediated oxidative stress and NF-kappaB-mediated collagen deposition. Estradiol 21-38 NADPH oxidase 4 Rattus norvegicus 87-91 30379725-0 2019 Physiological dosages of estradiol and diarylpropionitrile decrease depressive behavior and increase tryptophan hydroxylase expression in the dorsal raphe nucleus of rats subjected to the forced swim test. Estradiol 25-34 tryptophan hydroxylase 1 Rattus norvegicus 101-123 30598481-0 2019 The 17beta-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESRalpha and SP1 complex. Estradiol 4-20 adhesion G protein-coupled receptor G7 Homo sapiens 86-92 30020241-8 2019 In human renal and trophoblastic cells, testosterone and estradiol could regulate SerpinF2 expression in opposite ways. Estradiol 57-66 serpin family F member 2 Homo sapiens 82-90 30384123-2 2019 Here, we used serial section immunogold electron microscopy to examine whether phosphorylated tyrosine 1472 NR2B (pY1472), which is involved in the surface expression of NMDARs, is altered in the dorsal hippocampus of young (3-4 months old) and aged (~24 months old) ovariectomized rats treated with 17beta-estradiol or vehicle for 2 days. Estradiol 300-316 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 108-112 29402198-9 2019 Functionally, only simultaneous knockdown of GATA6 and NR5A1 blocked estradiol formation in OSIS ( P < .05). Estradiol 69-78 nuclear receptor subfamily 5, group A, member 1 Mus musculus 55-60 30237061-4 2018 First, beta-estradiol was used to validate the expression of active UGT1A1 protein in engineered HeLa1A1 cells. Estradiol 7-21 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 68-74 30371725-0 2018 17beta-estradiol promotes recovery after myocardial infarction by enhancing homing and angiogenic capacity of bone marrow-derived endothelial progenitor cells through ERalpha-SDF-1/CXCR4 crosstalking. Estradiol 0-16 chemokine (C-X-C motif) receptor 4 Mus musculus 181-186 29961889-0 2018 Action of neurotensin, corticotropin-releasing hormone, and RFamide-related peptide-3 in E2-induced negative feedback control: studies using a mouse arcuate nucleus hypothalamic cell model. Estradiol 89-91 neurotensin Mus musculus 10-21 29961889-0 2018 Action of neurotensin, corticotropin-releasing hormone, and RFamide-related peptide-3 in E2-induced negative feedback control: studies using a mouse arcuate nucleus hypothalamic cell model. Estradiol 89-91 corticotropin releasing hormone Mus musculus 23-54 29961889-2 2018 Here, we show that Kiss-1 gene expression in these cells was downregulated by 17beta-estradiol (E2) under certain conditions. Estradiol 78-94 KiSS-1 metastasis-suppressor Mus musculus 19-25 29961889-2 2018 Here, we show that Kiss-1 gene expression in these cells was downregulated by 17beta-estradiol (E2) under certain conditions. Estradiol 96-98 KiSS-1 metastasis-suppressor Mus musculus 19-25 29961889-3 2018 Both neurotensin (NT) and corticotropin-releasing hormone (CRH) were expressed in these cells and upregulated by E2. Estradiol 113-115 neurotensin Mus musculus 5-16 29961889-3 2018 Both neurotensin (NT) and corticotropin-releasing hormone (CRH) were expressed in these cells and upregulated by E2. Estradiol 113-115 corticotropin releasing hormone Mus musculus 26-57 29961889-3 2018 Both neurotensin (NT) and corticotropin-releasing hormone (CRH) were expressed in these cells and upregulated by E2. Estradiol 113-115 corticotropin releasing hormone Mus musculus 59-62 29961889-9 2018 On the other hand, in experiments using mHypoA-50 cells, which were originally derived from hypothalamic neurons in the anteroventral periventricular nucleus, Kiss-1 gene expression was upregulated by both NT and CRH, although E2 increased both NT and CRH expression, similarly to the mHypoA-55 cells. Estradiol 227-229 KiSS-1 metastasis-suppressor Mus musculus 159-165 30194276-0 2018 6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to beta-Estradiol. Estradiol 146-160 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 126-132 30328349-2 2018 miR microarray analysis and multiple confirmatory cell preparations treated with 17beta-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Estradiol 81-97 membrane associated ring-CH-type finger 8 Homo sapiens 0-3 30328349-2 2018 miR microarray analysis and multiple confirmatory cell preparations treated with 17beta-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Estradiol 81-97 membrane associated ring-CH-type finger 8 Homo sapiens 119-122 29505099-11 2018 Accordingly, we could demonstrate that estradiol but not testosterone induces KLK8 synthesis in neuronal and microglial cells. Estradiol 39-48 kallikrein related peptidase 8 Homo sapiens 78-82 29781507-9 2018 The reduction in Col1A1 mRNA expression due to estradiol treatment was positively correlated with ERalpha expression (r = 0.903, p < 0.01). Estradiol 47-56 collagen type I alpha 1 chain Homo sapiens 17-23 29908082-3 2018 17beta-estradiol activates S1R, thus here we investigated the role of sex-specific S1R activation and heat shock response in severe renal I/R injury. Estradiol 0-16 sigma non-opioid intracellular receptor 1 Rattus norvegicus 27-30 29908082-4 2018 Proximal tubular cells were treated with 17beta-estradiol, which caused direct S1R activation and subsequent induction of heat shock response. Estradiol 41-57 sigma non-opioid intracellular receptor 1 Rattus norvegicus 79-82 31949550-0 2018 High expression of ZEB1 in endometriosis and its role in 17beta-estradiol-induced epithelial-mesenchymal transition. Estradiol 57-73 zinc finger E-box binding homeobox 1 Homo sapiens 19-23 31949550-2 2018 The objective of this study was to determine the expression of ZEB1 in endometriosis and its role in 17beta-estradiol (E2)-induced epithelial-mesenchymal transition (EMT). Estradiol 101-117 zinc finger E-box binding homeobox 1 Homo sapiens 63-67 29751107-4 2018 We also demonstrate dual, negative and positive, regulation of Runx2-driven alkaline phosphatase (ALP) activity by increasing E2 concentrations in ST2 osteoblast progenitor cells. Estradiol 126-128 ST2 Homo sapiens 147-150 29883692-0 2018 17beta-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor. Estradiol 0-16 G protein-coupled estrogen receptor 1 Homo sapiens 60-95 29883692-3 2018 The G protein-coupled estrogen receptor (GPER) is known to facilitate rapid actions of 17beta-estradiol, though its role in modulation of ion channels is not widely explored. Estradiol 87-103 G protein-coupled estrogen receptor 1 Homo sapiens 4-39 29883692-3 2018 The G protein-coupled estrogen receptor (GPER) is known to facilitate rapid actions of 17beta-estradiol, though its role in modulation of ion channels is not widely explored. Estradiol 87-103 G protein-coupled estrogen receptor 1 Homo sapiens 41-45 29883692-5 2018 In the present study, using single channel cell-attached patch clamp electrophysiology in HEK293 cells, we show that 17beta-estradiol increases the activity of hTREK1 channel by acting through hGPER and increasing the channel opening probability within minutes. Estradiol 117-133 G protein-coupled estrogen receptor 1 Homo sapiens 193-198 29883692-8 2018 Mutational studies revealed the serines at positions 315 and 348 in the C-terminal domain of hTREK1 to be the target sites for dephosphorylation induced by 17beta-estradiol action through hGPER. Estradiol 156-172 G protein-coupled estrogen receptor 1 Homo sapiens 188-193 29883692-9 2018 Elucidation of the pathway for the potentiating action of 17beta-estradiol via hGPER on hTREK1 channel activity will help us understand better one of the many possible neuroprotective mechanisms of 17beta-estradiol and hTREK1 channel. Estradiol 58-74 G protein-coupled estrogen receptor 1 Homo sapiens 79-84 29883692-9 2018 Elucidation of the pathway for the potentiating action of 17beta-estradiol via hGPER on hTREK1 channel activity will help us understand better one of the many possible neuroprotective mechanisms of 17beta-estradiol and hTREK1 channel. Estradiol 198-214 G protein-coupled estrogen receptor 1 Homo sapiens 79-84 30150309-3 2018 Using an activation-tagging approach, we identified SRS5ox, which overexpresses SHI-RELATED SEQUENCE5 (SRS5) following induction with estradiol. Estradiol 134-143 SHI-related sequence 5 Arabidopsis thaliana 80-101 30150309-3 2018 Using an activation-tagging approach, we identified SRS5ox, which overexpresses SHI-RELATED SEQUENCE5 (SRS5) following induction with estradiol. Estradiol 134-143 SHI-related sequence 5 Arabidopsis thaliana 52-56 30036684-4 2018 Herein, we designed and optimized a validated cocktail method for the simultaneous evaluation of drug-mediated inhibition of the main five UGT isoforms using respective specific probe substrates (estradiol for UGT1A1, chenodeoxycholic acid for UGT1A3, serotonin for UGT1A6, propofol for UGT1A9/PROG and zidovudine for UGT2B7/AZTG) in human and rat liver microsomes by liquid chromatography-tandem mass spectrometry (LCMS/MS). Estradiol 196-205 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 210-216 30036684-4 2018 Herein, we designed and optimized a validated cocktail method for the simultaneous evaluation of drug-mediated inhibition of the main five UGT isoforms using respective specific probe substrates (estradiol for UGT1A1, chenodeoxycholic acid for UGT1A3, serotonin for UGT1A6, propofol for UGT1A9/PROG and zidovudine for UGT2B7/AZTG) in human and rat liver microsomes by liquid chromatography-tandem mass spectrometry (LCMS/MS). Estradiol 196-205 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 244-250 30036684-4 2018 Herein, we designed and optimized a validated cocktail method for the simultaneous evaluation of drug-mediated inhibition of the main five UGT isoforms using respective specific probe substrates (estradiol for UGT1A1, chenodeoxycholic acid for UGT1A3, serotonin for UGT1A6, propofol for UGT1A9/PROG and zidovudine for UGT2B7/AZTG) in human and rat liver microsomes by liquid chromatography-tandem mass spectrometry (LCMS/MS). Estradiol 196-205 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 318-324 30713608-9 2018 Progesterone and 17 beta-estradiol triggered P0 and S-100 genes expression and induced a cellular immunocytochemical staining positive rate of S-100 and GFAP in rats ADSCs. Estradiol 17-34 glial fibrillary acidic protein Rattus norvegicus 153-157 30133352-0 2018 Estradiol Affects Epstein-Barr Virus Reactivation-Induced Thyrotropin Receptor Antibody and Immunoglobulin Production in Graves" Disease Patients and Healthy Controls. Estradiol 0-9 thyroid stimulating hormone receptor Homo sapiens 58-78 29625166-0 2018 Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6/TAK1 pathway. Estradiol 68-77 TNF receptor associated factor 6 Rattus norvegicus 132-137 29625166-0 2018 Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6/TAK1 pathway. Estradiol 68-77 mitogen activated protein kinase kinase kinase 7 Rattus norvegicus 138-142 28567681-7 2018 The latter was more efficient in the removal of 17beta-estradiol (HF1: 30%, VF1: 50%), estrone (HF1: 63%, VF1: 85%), estriol (100% both), testosterone (HF1: 45%, VF1: 73%), boldenone (HF1:-77%, VF1: 100%) and progesterone (HF1: 84%, VF1: 99%). Estradiol 48-64 complement factor H Homo sapiens 66-69 29447857-3 2018 Here we investigated if 17beta-estradiol (E2) would be able to recover ORM deficits in animals with decreased expression of the Vesicular Acetylcholine Transporter (VAChT KDHET). Estradiol 24-40 solute carrier family 18 (vesicular monoamine), member 3 Mus musculus 128-163 29555237-0 2018 Kisspeptin system in ovariectomized mice: Estradiol and progesterone regulation. Estradiol 42-51 KiSS-1 metastasis-suppressor Mus musculus 0-10 29807145-6 2018 Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15). Estradiol 5-7 G protein-coupled estrogen receptor 1 Homo sapiens 75-80 29807145-6 2018 Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15). Estradiol 5-7 G protein-coupled estrogen receptor 1 Homo sapiens 223-228 29807145-6 2018 Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15). Estradiol 9-25 G protein-coupled estrogen receptor 1 Homo sapiens 75-80 29807145-6 2018 Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15). Estradiol 9-25 G protein-coupled estrogen receptor 1 Homo sapiens 223-228 29805678-0 2018 Inhibition of growth hormone receptor by Somavert reduces expression of GPER and prevents growth stimulation of triple-negative breast cancer by 17beta-estradiol. Estradiol 145-161 growth hormone receptor Homo sapiens 14-37 29805678-6 2018 Expression of GPER and activation of c-src and epidermal growth factor receptor (EGFR) by 17beta-estradiol was analyzed by western blotting. Estradiol 90-106 G protein-coupled estrogen receptor 1 Homo sapiens 14-18 29504156-5 2018 VEGFA and VEGFR2 proteins were elevated in vascular cells in follicular phase endometrium, compared to luteal phase, most significantly in response to oestradiol. Estradiol 151-161 kinase insert domain receptor Homo sapiens 10-16 29686616-5 2018 We demonstrated that estradiol treatment of adult PA exposed animals induced an increase in estrogen receptor (ER) alpha and insulin-like growth factor receptor (IGF-1R) protein levels, an activation of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 beta/beta-catenin signaling pathway and an increase in Bcl-2/Bax ratio in the hippocampus in comparison to PA exposed animals treated with vehicle. Estradiol 21-30 insulin like growth factor 1 receptor Homo sapiens 162-168 29686616-6 2018 Taking together, our data suggest that the interaction between ERalpha and IGF-IR, with the subsequent downstream activation, underlies the beneficial effects of estradiol observed in late treatment of PA. Estradiol 162-171 insulin like growth factor 1 receptor Homo sapiens 75-81 29608013-0 2018 17beta-Estradiol on the Expression of G-Protein Coupled Estrogen Receptor (GPER/GPR30) Mitophagy, and the PI3K/Akt Signaling Pathway in ATDC5 Chondrocytes In Vitro. Estradiol 0-16 G protein-coupled estrogen receptor 1 Homo sapiens 80-85 29608013-2 2018 G-protein coupled estrogen receptor (GPER/GPR30) activates cell signaling in response to 17beta-estradiol, which can be blocked by the GPR30 agonist, G15, an analog of G-1. Estradiol 89-105 G protein-coupled estrogen receptor 1 Homo sapiens 37-41 29608013-2 2018 G-protein coupled estrogen receptor (GPER/GPR30) activates cell signaling in response to 17beta-estradiol, which can be blocked by the GPR30 agonist, G15, an analog of G-1. Estradiol 89-105 G protein-coupled estrogen receptor 1 Homo sapiens 42-47 29608013-2 2018 G-protein coupled estrogen receptor (GPER/GPR30) activates cell signaling in response to 17beta-estradiol, which can be blocked by the GPR30 agonist, G15, an analog of G-1. Estradiol 89-105 G protein-coupled estrogen receptor 1 Homo sapiens 135-140 29608013-3 2018 The aims of this study were to investigate the effects of 17beta-estradiol on the expression of G-protein coupled estrogen receptor (GPER/GPR30) on mitophagy and the PI3K/Akt signaling pathway in ATDC5 chondrocytes in vitro. Estradiol 58-74 G protein-coupled estrogen receptor 1 Homo sapiens 133-137 29608013-3 2018 The aims of this study were to investigate the effects of 17beta-estradiol on the expression of G-protein coupled estrogen receptor (GPER/GPR30) on mitophagy and the PI3K/Akt signaling pathway in ATDC5 chondrocytes in vitro. Estradiol 58-74 G protein-coupled estrogen receptor 1 Homo sapiens 138-143 29608013-9 2018 RESULTS In 17beta-estradiol-treated ATDC5 chondrocytes, increased expression of GPER/GPR30 was found, but fewer mitophagosomes were observed, and decreased numbers of TOM20-positive granules were co-localized with decreased LAMP2 and increased expression levels of TOM20, Hsp60, p-Akt, and p-mTOR, and reduced expression of LC3-II, were found. Estradiol 11-27 G protein-coupled estrogen receptor 1 Homo sapiens 80-84 29608013-9 2018 RESULTS In 17beta-estradiol-treated ATDC5 chondrocytes, increased expression of GPER/GPR30 was found, but fewer mitophagosomes were observed, and decreased numbers of TOM20-positive granules were co-localized with decreased LAMP2 and increased expression levels of TOM20, Hsp60, p-Akt, and p-mTOR, and reduced expression of LC3-II, were found. Estradiol 11-27 G protein-coupled estrogen receptor 1 Homo sapiens 85-90 29608013-9 2018 RESULTS In 17beta-estradiol-treated ATDC5 chondrocytes, increased expression of GPER/GPR30 was found, but fewer mitophagosomes were observed, and decreased numbers of TOM20-positive granules were co-localized with decreased LAMP2 and increased expression levels of TOM20, Hsp60, p-Akt, and p-mTOR, and reduced expression of LC3-II, were found. Estradiol 11-27 lysosomal associated membrane protein 2 Homo sapiens 224-229 29608013-9 2018 RESULTS In 17beta-estradiol-treated ATDC5 chondrocytes, increased expression of GPER/GPR30 was found, but fewer mitophagosomes were observed, and decreased numbers of TOM20-positive granules were co-localized with decreased LAMP2 and increased expression levels of TOM20, Hsp60, p-Akt, and p-mTOR, and reduced expression of LC3-II, were found. Estradiol 11-27 heat shock protein family D (Hsp60) member 1 Homo sapiens 272-277 29608013-11 2018 CONCLUSIONS Treatment with 17beta-estradiol protected ATDC5 chondrocytes against mitophagy via the GPER/GPR30 and the PI3K/Akt signaling pathway. Estradiol 27-43 G protein-coupled estrogen receptor 1 Homo sapiens 99-103 29608013-11 2018 CONCLUSIONS Treatment with 17beta-estradiol protected ATDC5 chondrocytes against mitophagy via the GPER/GPR30 and the PI3K/Akt signaling pathway. Estradiol 27-43 G protein-coupled estrogen receptor 1 Homo sapiens 104-109 29396042-10 2018 Estradiol release was promoted by leptin and ghrelin in BCS3 cells; however, it was unaffected by leptin and inhibited by ghrelin in BCS2 cells. Estradiol 0-9 leptin Bos taurus 34-40 29396042-10 2018 Estradiol release was promoted by leptin and ghrelin in BCS3 cells; however, it was unaffected by leptin and inhibited by ghrelin in BCS2 cells. Estradiol 0-9 ghrelin and obestatin prepropeptide Bos taurus 45-52 29396042-10 2018 Estradiol release was promoted by leptin and ghrelin in BCS3 cells; however, it was unaffected by leptin and inhibited by ghrelin in BCS2 cells. Estradiol 0-9 ghrelin and obestatin prepropeptide Bos taurus 122-129 29562734-4 2018 In this review, we focus on recent insights into the pathogenetic roles of E2s (particularly the ubiquitin-conjugating enzyme E2O [UBE2O]) in debilitating diseases and cancer, and discuss the tantalizing prospect that E2s may someday serve as potential therapeutic targets for human diseases. Estradiol 75-78 ubiquitin conjugating enzyme E2 O Homo sapiens 97-129 29562734-4 2018 In this review, we focus on recent insights into the pathogenetic roles of E2s (particularly the ubiquitin-conjugating enzyme E2O [UBE2O]) in debilitating diseases and cancer, and discuss the tantalizing prospect that E2s may someday serve as potential therapeutic targets for human diseases. Estradiol 75-78 ubiquitin conjugating enzyme E2 O Homo sapiens 131-137 29378329-0 2018 miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis. Estradiol 47-56 cytochrome P450 family 19 subfamily A member 1 Sus scrofa 86-93 29467896-0 2018 17beta-estradiol regulates the malignancy of cancer stem-like cells derived from the MCF7 cell line partially through Sox2. Estradiol 0-16 SRY-box transcription factor 2 Homo sapiens 118-122 29197292-8 2018 Increasing doses of interleukin-1beta decreased levels of ID2 mRNA, while estradiol-17beta increased levels of ID3 mRNA in endometrial explants. Estradiol 74-90 inhibitor of DNA binding 3, HLH protein Sus scrofa 111-114 29172740-5 2018 Furthermore, we demonstrate that estrogen declines following ovariectomy modulates the daily rhythm expression of Bmal1, Per1 and Per2 in female rat CP, corroborating data obtained in experiments where rat CP epithelial cell (CPEC) cultures were incubated with 17beta-estradiol (E2). Estradiol 261-277 aryl hydrocarbon receptor nuclear translocator-like Rattus norvegicus 114-119 28529128-2 2018 The primary physiological estrogen 17beta-estradiol (E2), a non-selective agonist of classical nuclear estrogen receptors (ERalpha and ERbeta) as well as the G protein-coupled estrogen receptor (GPER), stimulates formation of the vasodilator nitric oxide (NO) in endothelial cells. Estradiol 35-51 G protein-coupled estrogen receptor 1 Mus musculus 195-199 28529128-11 2018 These findings indicate that a substantial portion of E2-induced endothelium-dependent vasodilation and NO formation is mediated by GPER. Estradiol 54-56 G protein-coupled estrogen receptor 1 Mus musculus 132-136 30056756-0 2018 17beta-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model. Estradiol 0-16 matrix metallopeptidase 3 Rattus norvegicus 78-83 30056756-0 2018 17beta-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model. Estradiol 0-16 matrix metallopeptidase 13 Rattus norvegicus 88-129 29069304-11 2018 These results indicate that CRH alters GnRH neuron activity and that estradiol is required for CRH to exert both stimulatory and inhibitory effects on GnRH neurons. Estradiol 69-78 corticotropin releasing hormone Mus musculus 95-98 29114012-14 2018 17beta-Estradiol increased RBP4 mRNA in adipocytes. Estradiol 0-16 retinol binding protein 4, plasma Mus musculus 27-31 29138859-0 2018 17beta-estradiol attenuates ovariectomy-induced bone deterioration through the suppression of the ephA2/ephrinA2 signaling pathway. Estradiol 0-16 ephrin A2 Rattus norvegicus 104-112 29138859-1 2018 The present study aimed to investigate whether 17beta-estradiol (E2) exerts protective effects on bone deterioration induced by ovariectomy (OVX) through the ephA2/ephrinA2 signaling pathway in rats. Estradiol 47-63 ephrin A2 Rattus norvegicus 164-172 28567564-1 2017 The aim of this study was to investigate whether the presence of endogenous estradiol alters the effects of a high-fat (HF) diet on activity/expression of the cardiac Na+/K+-ATPase, via PI3K/IRS and RhoA/ROCK signalling cascades in female rats. Estradiol 76-85 ras homolog family member A Rattus norvegicus 199-203 29098175-4 2017 We first showed that approximately half of the pubertally born AVPV cells are activated by estradiol plus progesterone (P) treatment, as demonstrated by Fos expression, and that approximately 10% of pubertally born AVPV cells express estrogen receptor alpha (ERalpha). Estradiol 91-100 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 153-156 29096715-7 2017 RESULTS: 17beta-estradiol at 1 muM downregulated vimentin and CD13 and upregulated cytokeratin and CD9 proteins, promoting the differentiation of WJ-MSCs into EEC-like cells in the coculture system. Estradiol 9-25 CD9 molecule Homo sapiens 99-102 28797922-4 2017 Additionally, Vit D3 increased the cyclic adenosine monophosphate (cAMP), estradiol (E2), and progesterone (P4) levels, while it decreased anti-mullerian hormone receptor (AMHR) and follicle-stimulating hormone receptor (FSHR) mRNA expression (P < 0.05). Estradiol 74-83 vitrin Capra hircus 14-17 28442026-4 2017 Oestradiol in the ganglion decreased ovarian P4, E2 and NA release, as well as 3beta-HSD activity, but increased the release of A2 and nitrites, as well as the 20alpha-HSD expression and its activity. Estradiol 0-10 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 79-88 29137421-3 2017 This raises questions about the role of signalling through other estrogen receptors such as ERalpha or G-protein coupled estrogen receptor (GPER, GPR30) by the estrogen 17beta-estradiol (E2) under hypoxic conditions after ERbeta is lost in CRC progression. Estradiol 169-185 G protein-coupled estrogen receptor 1 Homo sapiens 103-138 29137421-3 2017 This raises questions about the role of signalling through other estrogen receptors such as ERalpha or G-protein coupled estrogen receptor (GPER, GPR30) by the estrogen 17beta-estradiol (E2) under hypoxic conditions after ERbeta is lost in CRC progression. Estradiol 169-185 G protein-coupled estrogen receptor 1 Homo sapiens 140-144 29137421-3 2017 This raises questions about the role of signalling through other estrogen receptors such as ERalpha or G-protein coupled estrogen receptor (GPER, GPR30) by the estrogen 17beta-estradiol (E2) under hypoxic conditions after ERbeta is lost in CRC progression. Estradiol 169-185 G protein-coupled estrogen receptor 1 Homo sapiens 146-151 28871193-3 2017 Thioredoxin (Trx) and its endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with the protective effect of estradiol in some conditions. Estradiol 134-143 thioredoxin 1 Mus musculus 0-11 28871193-3 2017 Thioredoxin (Trx) and its endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with the protective effect of estradiol in some conditions. Estradiol 134-143 thioredoxin 1 Mus musculus 13-16 28552400-1 2017 Celecoxib is known to alter the preferred position of SULT2A1-catalyzed sulfonation of 17beta-estradiol (17beta-E2) and other estrogens from the 3- to the 17-position. Estradiol 87-103 sulfotransferase family 2A member 1 Homo sapiens 54-61 28645527-1 2017 17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD7) promotes breast cancer cell growth via dual-catalytic activity by modulating estradiol and DHT. Estradiol 134-143 RNA, U1 small nuclear 4 Homo sapiens 0-55 28860448-7 2017 In addition, THRSP was significantly upregulated (P < 0.05) when chickens or chicken primary hepatocytes were treated with 17beta-estradiol in both the in vivo and in vitro conditions. Estradiol 126-142 thyroid hormone responsive Gallus gallus 13-18 28412354-2 2017 In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis. Estradiol 53-69 G protein-coupled estrogen receptor 1 Homo sapiens 104-133 28412354-2 2017 In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis. Estradiol 53-69 G protein-coupled estrogen receptor 1 Homo sapiens 135-140 28412354-2 2017 In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis. Estradiol 74-76 G protein-coupled estrogen receptor 1 Homo sapiens 104-133 28412354-2 2017 In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis. Estradiol 74-76 G protein-coupled estrogen receptor 1 Homo sapiens 135-140 28498246-10 2017 While MEK inhibition blocked estradiol-stimulated phosphorylation of ERK1/2 and p90RSK in wild-type cells, phospho-ERK1/2 and phospho-p90RSK were substantially increased in KRas mutants. Estradiol 29-38 KRAS proto-oncogene, GTPase Homo sapiens 173-177 28100475-4 2017 The results showed that a high-fat diet causes obesity, leptin resistance, inhibition of the testicular LEP-JAK-STAT pathway, decreased mRNA and protein expression of steroidogenic factor-1, steroidogenic acute regulatory protein, and the P-450 side-chain cleavage enzyme, a decrease in the serum testosterone-to-estradiol ratio, and declines in sperm quality parameters. Estradiol 313-322 nuclear receptor subfamily 5, group A, member 1 Mus musculus 167-189 27837347-5 2017 Both TAM and estradiol (E2) could promote the migration of triple negative (ER-alpha66-/PR-/HER2-) and ER-alpha36+/GPER1+ breast cancer cells MDA-MB-231. Estradiol 13-22 G protein-coupled estrogen receptor 1 Homo sapiens 115-120 27981512-5 2017 Our findings revealed that there is a moderately positive correlation between brain-derived neurotrophic factor and oestradiol in females, and decreased brain-derived neurotrophic factor may worsen impaired insulin function. Estradiol 116-126 brain derived neurotrophic factor Homo sapiens 78-111 27981512-7 2017 The level of brain-derived neurotrophic factor reduced on condition that the level of oestradiol is sufficiently low, such as women in postmenopausal period, which aggravates diabetes through feeding-related pathways. Estradiol 86-96 brain derived neurotrophic factor Homo sapiens 13-46 28382233-9 2017 17beta-estradiol regulates oxytocin and its receptor in skeletal muscle cells and they act in a synergic way on fatty acid metabolism. Estradiol 0-16 oxytocin/neurophysin I prepropeptide Homo sapiens 27-35 28382233-11 2017 17beta-estradiol regulates oxytocin and its receptor in skeletal muscle cells. Estradiol 0-16 oxytocin/neurophysin I prepropeptide Homo sapiens 27-35 28529452-0 2017 Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1. Estradiol 0-9 serum/glucocorticoid regulated kinase 1 Homo sapiens 128-132 28791837-7 2017 OBJECTIVES: The aim of this study was to evaluate the influence of 2 17beta-estradiol metabolites - 4-hydroxyestradiol (4-OHE2) and 16alpha-hydroxyestrone (16alpha-OHE1) - in conditions of oxidative stress caused by CrVI. Estradiol 69-85 ATPase H+ transporting accessory protein 1 Homo sapiens 156-163 28077306-7 2017 Increased hippocampal BDNF expression was observed in animals fed an isoflavone-rich diet after E2 administration (p<0.05). Estradiol 96-98 brain-derived neurotrophic factor Rattus norvegicus 22-26 28166815-6 2017 ESR2-dependent regulation of SMR3A was supported by induced expression after stimulation with estradiol (E2), which was impaired by co-treatment with 4-Hydroxytamoxifen (TAM) or Fulvestrant, respectively. Estradiol 94-103 submaxillary gland androgen regulated protein 3A Homo sapiens 29-34 27997350-1 2017 OBJECTIVE: Serum concentrations of estradiol (E2) and testosterone (testo) measured by mass spectrometry-based assays should remain below the 95th centile measured at 9.3 pg/mL for E2 and 0.26 ng/mL for testo in normal postmenopausal women in order to avoid the risk of non-physiological systemic exposure to elevated serum concentrations of these two sex steroids. Estradiol 35-44 cystatin 12, pseudogene Homo sapiens 181-189 27959426-0 2017 17beta-estradiol-induced growth of triple-negative breast cancer cells is prevented by the reduction of GPER expression after treatment with gefitinib. Estradiol 0-16 G protein-coupled estrogen receptor 1 Homo sapiens 104-108 27959426-3 2017 To a certain extent the growth of TNBCs is stimulated by 17beta-estradiol via GPER. Estradiol 57-73 G protein-coupled estrogen receptor 1 Homo sapiens 78-82 27959426-6 2017 Expression of GPR30 and activation of c-src, EGFR and cAMP-responsive element binding (CREB) protein by 17beta-estradiol was analyzed by western blotting. Estradiol 104-120 G protein-coupled estrogen receptor 1 Homo sapiens 14-19 27959426-6 2017 Expression of GPR30 and activation of c-src, EGFR and cAMP-responsive element binding (CREB) protein by 17beta-estradiol was analyzed by western blotting. Estradiol 104-120 cAMP responsive element binding protein 1 Homo sapiens 54-85 27959426-6 2017 Expression of GPR30 and activation of c-src, EGFR and cAMP-responsive element binding (CREB) protein by 17beta-estradiol was analyzed by western blotting. Estradiol 104-120 cAMP responsive element binding protein 1 Homo sapiens 87-91 27959426-16 2017 Phosphorylation of CREB and induction of c-fos, cyclin D1 and aromatase expression by 17beta-estradiol were all prevented by gefitinib. Estradiol 86-102 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 41-46 28035066-7 2017 While, knocking down hnRNPA1 through the transfection of hnRNPA1 siRNA led to the increase of MDM2 at both protein level and gene level In vivo experiment, subcutaneous injection with estradiol every two days near the tumor at doses of 2.5mg/kg/d suppressed tumor growth and reduced MDM2 expression. Estradiol 184-193 MDM2 proto-oncogene Homo sapiens 94-98 28035066-7 2017 While, knocking down hnRNPA1 through the transfection of hnRNPA1 siRNA led to the increase of MDM2 at both protein level and gene level In vivo experiment, subcutaneous injection with estradiol every two days near the tumor at doses of 2.5mg/kg/d suppressed tumor growth and reduced MDM2 expression. Estradiol 184-193 MDM2 proto-oncogene Homo sapiens 283-287 27870444-4 2017 In this report, we examined a potential downstream regulator of the effects of estradiol on hippocampal cell proliferation by measuring gene expression of brain-derived neurotrophin (BDNF) in male and female neonatal rats in response to estradiol. Estradiol 79-88 brain-derived neurotrophic factor Rattus norvegicus 183-187 27870444-4 2017 In this report, we examined a potential downstream regulator of the effects of estradiol on hippocampal cell proliferation by measuring gene expression of brain-derived neurotrophin (BDNF) in male and female neonatal rats in response to estradiol. Estradiol 237-246 brain-derived neurotrophic factor Rattus norvegicus 183-187 27870444-6 2017 Neonatal administration of exogenous estradiol resulted in opposite effects on BDNF expression in these areas of the neonatal hippocampus, such that BDNF transcripts increased in CA1 but decreased in dentate. Estradiol 37-46 brain-derived neurotrophic factor Rattus norvegicus 79-83 27870444-6 2017 Neonatal administration of exogenous estradiol resulted in opposite effects on BDNF expression in these areas of the neonatal hippocampus, such that BDNF transcripts increased in CA1 but decreased in dentate. Estradiol 37-46 brain-derived neurotrophic factor Rattus norvegicus 149-153 27870444-7 2017 Blocking endogenous estradiol signaling by antagonizing estrogen receptors decreased BDNF expression in the dentate of males, but not females, and had no effect in CA1. Estradiol 20-29 brain-derived neurotrophic factor Rattus norvegicus 85-89 28662498-8 2017 ERs and GPER blockers were able to prevent the effects of 17beta-estradiol and genistein. Estradiol 58-74 G protein-coupled estrogen receptor 1 Homo sapiens 8-12 28662498-9 2017 CONCLUSION: In Huh7.5 and LX-2, 17beta-estradiol and genistein counteract the effects of peroxidation through the involvement of ERs and GPER and by an intracellular signalling related to Akt and p38MAPK. Estradiol 32-48 MIR7-3 host gene Homo sapiens 15-19 28662498-9 2017 CONCLUSION: In Huh7.5 and LX-2, 17beta-estradiol and genistein counteract the effects of peroxidation through the involvement of ERs and GPER and by an intracellular signalling related to Akt and p38MAPK. Estradiol 32-48 G protein-coupled estrogen receptor 1 Homo sapiens 137-141 27614457-10 2017 Testosterone, estradiol and androgen-binding protein levels were altered in both serum and TIF in PCB treated groups. Estradiol 14-23 pyruvate carboxylase Rattus norvegicus 98-101 28810246-4 2017 Since GPER is highly expressed in microglia, we speculate that GPER mediates the neuroprotective function of estradiol through suppressing the neuroinflammation of PD. Estradiol 109-118 G protein-coupled estrogen receptor 1 Mus musculus 6-10 28810246-4 2017 Since GPER is highly expressed in microglia, we speculate that GPER mediates the neuroprotective function of estradiol through suppressing the neuroinflammation of PD. Estradiol 109-118 G protein-coupled estrogen receptor 1 Mus musculus 63-67 27930699-2 2016 We have previously delineated a novel mechanism of how 17beta-estradiol (E2) protects cultured neonatal rat cardiomyocytes from hypoxia/reoxygenation (H/R) by identifying a functionally active mitochondrial pool of p38beta and E2-driven upregulation of manganese superoxide dismutase (MnSOD) activity via p38beta, leading to the suppression of reactive oxygen species (ROS) and apoptosis. Estradiol 55-71 mitogen-activated protein kinase 11 Rattus norvegicus 215-222 27930699-2 2016 We have previously delineated a novel mechanism of how 17beta-estradiol (E2) protects cultured neonatal rat cardiomyocytes from hypoxia/reoxygenation (H/R) by identifying a functionally active mitochondrial pool of p38beta and E2-driven upregulation of manganese superoxide dismutase (MnSOD) activity via p38beta, leading to the suppression of reactive oxygen species (ROS) and apoptosis. Estradiol 55-71 superoxide dismutase 2 Rattus norvegicus 253-283 27930699-2 2016 We have previously delineated a novel mechanism of how 17beta-estradiol (E2) protects cultured neonatal rat cardiomyocytes from hypoxia/reoxygenation (H/R) by identifying a functionally active mitochondrial pool of p38beta and E2-driven upregulation of manganese superoxide dismutase (MnSOD) activity via p38beta, leading to the suppression of reactive oxygen species (ROS) and apoptosis. Estradiol 55-71 superoxide dismutase 2 Rattus norvegicus 285-290 27930699-2 2016 We have previously delineated a novel mechanism of how 17beta-estradiol (E2) protects cultured neonatal rat cardiomyocytes from hypoxia/reoxygenation (H/R) by identifying a functionally active mitochondrial pool of p38beta and E2-driven upregulation of manganese superoxide dismutase (MnSOD) activity via p38beta, leading to the suppression of reactive oxygen species (ROS) and apoptosis. Estradiol 55-71 mitogen-activated protein kinase 11 Rattus norvegicus 305-312 27507595-1 2016 Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17beta-estradiol (E2) on the HPG axis. Estradiol 122-138 KiSS-1 metastasis-suppressor Mus musculus 31-41 27507595-1 2016 Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17beta-estradiol (E2) on the HPG axis. Estradiol 122-138 KiSS-1 metastasis-suppressor Mus musculus 43-48 27507595-1 2016 Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17beta-estradiol (E2) on the HPG axis. Estradiol 122-138 prodynorphin Mus musculus 87-91 27756766-7 2016 These transitions in transcript levels might have been mediated by Pax2 acting upstream of wnt4/5 that may play a role in steroidogenesis and/or ovarian development along with ad4bp/sf-1 or by direct or indirect interaction with steroidogenic enzyme genes, which is evident from the change in the levels of serum estradiol-17beta but not 17alpha,20beta-dihydroxy-4-pregnen-3-one. Estradiol 313-322 paired box 2 Homo sapiens 67-71 27378405-2 2016 For this purpose, we compared the effects of chicken and human ghrelin on the release of estradiol (E), testosterone (T), progesterone (P) and arginine-vasotocin (AVT) by cultured fragments of chicken ovarian follicles and on the release of T and AVT by cultured ovarian granulosa cells. Estradiol 89-98 ghrelin/obestatin prepropeptide Gallus gallus 63-70 27437916-0 2016 17-beta-estradiol Decreases Neutrophil Superoxide Production through Rac1. Estradiol 0-17 Rac family small GTPase 1 Homo sapiens 69-73 27615377-12 2016 The expression levels of CFTR and SLC26A6 in young women were markedly higher in preovulatory phases than in premenstrual phases, which was consistent with the changes of serum estradiol concentrations. Estradiol 177-186 solute carrier family 26 member 6 Homo sapiens 34-41 27615377-13 2016 Further results showed that duodenal CFTR and SLC26A6 expression levels in female mice were markedly decreased after ovariectomy, and supplementation with estradiol reversed the changes in CFTR and SLC26A6. Estradiol 155-164 cystic fibrosis transmembrane conductance regulator Mus musculus 37-41 27615377-13 2016 Further results showed that duodenal CFTR and SLC26A6 expression levels in female mice were markedly decreased after ovariectomy, and supplementation with estradiol reversed the changes in CFTR and SLC26A6. Estradiol 155-164 cystic fibrosis transmembrane conductance regulator Mus musculus 189-193 27615377-14 2016 17beta-Estradiol increased CFTR and SLC26A6 expression levels of human duodenocytes in experiments in vitro. Estradiol 0-16 cystic fibrosis transmembrane conductance regulator Mus musculus 27-31 27255147-6 2016 After the administration of 17beta-estradiol and leptin, we observed antagonistic effects of 17beta-estradiol on leptin-induced OVCAR-3 cell migration and MMP-9 expression and activity. Estradiol 28-44 matrix metallopeptidase 9 Homo sapiens 155-160 27255147-6 2016 After the administration of 17beta-estradiol and leptin, we observed antagonistic effects of 17beta-estradiol on leptin-induced OVCAR-3 cell migration and MMP-9 expression and activity. Estradiol 93-109 matrix metallopeptidase 9 Homo sapiens 155-160 27255147-8 2016 Taken together, our results, for the first time, show that in ovarian cancer cells ObR+/ER+, 17beta-estradiol has an antagonistic effect on leptin-induced cell migration as well as MMP-9 expression and activity, which is mediated by the PI3K pathway. Estradiol 93-109 matrix metallopeptidase 9 Homo sapiens 181-186 27676153-6 2016 Fusidic acid also inhibited UGT1A1-catalyzed beta-estradiol glucuronidation activity in human liver microsomes with an IC50 value of 16 muM. Estradiol 45-59 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 28-34 27192429-10 2016 Estradiol treatment improved glucose intolerance in OVX mice and restored insulin secretion, as well as normalized the protein content of pancreatic Synt-1A. Estradiol 0-9 syntaxin 1A (brain) Mus musculus 149-156 27001231-6 2016 In more detailed studies undertaken on TRPC1 and 6, we show that protein expression varied through the estrus cycle; specifically, 17beta-estradiol, FSH, and LH individually and in combination upregulated TRPC1 and 6 expression in cultured bovine oviduct epithelial cells although progesterone antagonized these effects. Estradiol 131-147 transient receptor potential cation channel subfamily C member 1 Bos taurus 39-50 27001231-6 2016 In more detailed studies undertaken on TRPC1 and 6, we show that protein expression varied through the estrus cycle; specifically, 17beta-estradiol, FSH, and LH individually and in combination upregulated TRPC1 and 6 expression in cultured bovine oviduct epithelial cells although progesterone antagonized these effects. Estradiol 131-147 transient receptor potential cation channel subfamily C member 1 Bos taurus 39-44 27344558-6 2016 The typical oestrogen, 17beta-estradiol (17beta-E2), was detected above the method limit of quantification (m-LOQ) in 5 of 14 analysed tap water samples at concentrations from 0.09 to 0.15 ng L(-1). Estradiol 23-39 nuclear RNA export factor 1 Homo sapiens 135-138 27280155-0 2016 Excitability and Burst Generation of AVPV Kisspeptin Neurons Are Regulated by the Estrous Cycle Via Multiple Conductances Modulated by Estradiol Action. Estradiol 135-144 KiSS-1 metastasis-suppressor Mus musculus 42-52 27280155-3 2016 Kisspeptin neurons in anteroventral periventricular nucleus (AVPV) are thought to be critical for estradiol-positive feedback induction of the GnRH surge. Estradiol 98-107 KiSS-1 metastasis-suppressor Mus musculus 0-10 27280155-14 2016 Manipulation of specific sex steroids suggests that estradiol induces the changes that enhance AVPV kisspeptin neuron excitability on proestrus. Estradiol 52-61 KiSS-1 metastasis-suppressor Mus musculus 100-110 26931423-0 2016 17beta-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-gamma/STAT1-dependent miR-7 upregulation. Estradiol 0-16 signal transducer and activator of transcription 1 Homo sapiens 97-102 26676302-7 2016 After 12 h of estradiol exposure, a downregulation of this PR isoform was associated with a decrease of specific protein 1, histone 3 lysine 4 trimethylation, and RNA polymerase II occupancy on PR-B promoter, without changes in DNA methylation and hydroxymethylation. Estradiol 14-23 progesterone receptor Mus musculus 194-198 27046435-8 2016 In contrast, estradiol-17beta treatment only partially rescued the gonadal phenotype of Sf-1-deficient XX fish, as demonstrated by the appearance of phase II oocytes. Estradiol 13-29 steroidogenic factor 1 Oreochromis niloticus 88-92 27111051-1 2016 UNLABELLED: Estradiol mediates its actions by binding to classical nuclear receptors, estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta), and the non-classical G protein-coupled estrogen receptor 1(GPER). Estradiol 12-21 G protein-coupled estrogen receptor 1 Homo sapiens 181-218 27111051-1 2016 UNLABELLED: Estradiol mediates its actions by binding to classical nuclear receptors, estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta), and the non-classical G protein-coupled estrogen receptor 1(GPER). Estradiol 12-21 G protein-coupled estrogen receptor 1 Homo sapiens 219-223 27664484-5 2016 Surprisingly, 17beta-estradiol (E2) treatment led to remarkably reduced RANKL compared with that in E2 untreated cells. Estradiol 14-30 TNF superfamily member 11 Homo sapiens 72-77 26945908-12 2016 17beta-estradiol inhibits IL8-up-regulated Src downstream target proteins including p-Cas, p-paxillin, p-ERK1/2, p-JNK1/2, MMP9, tPA and uPA. Estradiol 0-16 matrix metallopeptidase 9 Homo sapiens 123-127 26789235-0 2016 Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A. Estradiol 88-97 intercellular adhesion molecule 5, telencephalin Mus musculus 0-5 27358124-7 2016 It can be concluded that estradiol is able to promote the proliferation of osteoblasts in mice by ERalpha-mediated Wnt/beta-catenin signaling pathway. Estradiol 25-34 catenin (cadherin associated protein), beta 1 Mus musculus 119-131 25427133-8 2016 Specifically, oestradiol, when combined with IGF-1, insulin and FSH, stimulated HAS2 mRNA expression. Estradiol 14-24 LOC105613195 Ovis aries 52-59 26676955-0 2016 MicroRNA-764-3p regulates 17beta-estradiol synthesis of mouse ovarian granulosa cells by targeting steroidogenic factor-1. Estradiol 26-42 nuclear receptor subfamily 5, group A, member 1 Mus musculus 99-121 26490364-6 2016 Silencing of ER-beta attenuated 17beta-estradiol mediated decrease in caspase 1, ASC, and IL-1beta. Estradiol 32-48 caspase 1 Rattus norvegicus 70-79 26490364-6 2016 Silencing of ER-beta attenuated 17beta-estradiol mediated decrease in caspase 1, ASC, and IL-1beta. Estradiol 32-48 PYD and CARD domain containing Rattus norvegicus 81-84 26726951-2 2016 17beta-estradiol (E2)-mediated regulation of these neurons is nuclei specific, where anteroventral periventricular (AVPV) Kiss neurons are positively regulated by E2, whereas arcuate nucleus (ARC) neurons are inhibited. Estradiol 0-16 KiSS-1 metastasis-suppressor Mus musculus 122-126 26264729-0 2016 17beta-Estradiol modulates huntingtin levels in rat tissues and in human neuroblastoma cell line. Estradiol 0-16 huntingtin Rattus norvegicus 27-37 26646255-9 2016 Vitamin-D and estradiol 17-beta upregulated VDR expression. Estradiol 14-31 vitamin D receptor Homo sapiens 44-47 26917263-0 2016 c-Fos-Regulated Matrix Metalloproteinase-9 Expression is Involved in 17beta-Estradiol-Promoted Invasion of Human Endometrial Stromal Cell. Estradiol 69-85 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 0-5 26917263-0 2016 c-Fos-Regulated Matrix Metalloproteinase-9 Expression is Involved in 17beta-Estradiol-Promoted Invasion of Human Endometrial Stromal Cell. Estradiol 69-85 matrix metallopeptidase 9 Homo sapiens 16-42 26904272-11 2016 Serum 17beta-estradiol levels were positively correlated with tear MMP-2 and MMP-9 concentrations and negatively correlated with Schirmer test values. Estradiol 6-22 matrix metallopeptidase 9 Homo sapiens 77-82 26765570-0 2016 Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling. Estradiol 0-9 proopiomelanocortin Rattus norvegicus 67-86 26765570-1 2016 Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Estradiol 0-9 proopiomelanocortin Rattus norvegicus 66-85 26765570-1 2016 Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Estradiol 0-9 proopiomelanocortin Rattus norvegicus 87-91 26765570-3 2016 Therefore, we tested the hypothesis that estradiol excites POMC neurons by rapidly attenuating inhibitory ORL-1 signaling in these cells. Estradiol 41-50 proopiomelanocortin Rattus norvegicus 59-63 26735933-2 2016 In the human placenta, 3beta-hydroxysteroid dehydrogenase 1 (HSD3B1) is responsible for the formation of progesterone from pregnenolone and aromatase (CYP19A1) for the production of estradiol from androgen. Estradiol 182-191 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 23-59 26735933-2 2016 In the human placenta, 3beta-hydroxysteroid dehydrogenase 1 (HSD3B1) is responsible for the formation of progesterone from pregnenolone and aromatase (CYP19A1) for the production of estradiol from androgen. Estradiol 182-191 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 61-67 26348925-0 2015 Estrogen receptor alpha L429 and A430 regulate 17beta-estradiol-induced cell proliferation via CREB1. Estradiol 54-63 cAMP responsive element binding protein 1 Homo sapiens 95-100 25980457-0 2015 Contribution of estrogen receptor subtypes, ERalpha, ERbeta, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice. Estradiol 80-89 G protein-coupled estrogen receptor 1 Mus musculus 65-70 26442993-0 2015 Reduction in Abeta-induced cell death in the hippocampus of 17beta-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone. Estradiol 60-76 amyloid beta precursor protein Rattus norvegicus 13-18 26442993-1 2015 Several studies indicate that 17beta-estradiol (E2) protects against amyloid beta-peptide (Abeta)-induced cell death and activates factors associated with learning and memory, a function involving the hippocampal somatostatinergic system. Estradiol 30-46 amyloid beta precursor protein Rattus norvegicus 91-96 26442993-1 2015 Several studies indicate that 17beta-estradiol (E2) protects against amyloid beta-peptide (Abeta)-induced cell death and activates factors associated with learning and memory, a function involving the hippocampal somatostatinergic system. Estradiol 48-50 amyloid beta precursor protein Rattus norvegicus 91-96 26442993-4 2015 Co-administration of E2 with Abeta25-35 reduced both its levels and cell death, in addition to preventing the Abeta-induced depletion of some somatostatinergic parameters. Estradiol 21-23 amyloid beta precursor protein Rattus norvegicus 29-34 26442993-7 2015 Moreover, neprilysin levels were increased only in Abeta plus E2-treated rats and E2 prevented the Abeta-induced insulin-degrading-enzyme reduction. Estradiol 62-64 membrane metallo-endopeptidase Rattus norvegicus 10-20 26442993-8 2015 Our results suggest that the E2-induced reduction in cell death is related to lower Abeta levels, probably because of IGF-I and somatostatin modulation of Abeta proteases. Estradiol 29-31 amyloid beta precursor protein Rattus norvegicus 84-89 26442993-8 2015 Our results suggest that the E2-induced reduction in cell death is related to lower Abeta levels, probably because of IGF-I and somatostatin modulation of Abeta proteases. Estradiol 29-31 amyloid beta precursor protein Rattus norvegicus 155-160 26442993-9 2015 We asked how 17beta-estradiol (E2) protects against beta-amyloid (Abeta)-induced cell death. Estradiol 13-29 amyloid beta precursor protein Rattus norvegicus 66-71 26442993-9 2015 We asked how 17beta-estradiol (E2) protects against beta-amyloid (Abeta)-induced cell death. Estradiol 31-33 amyloid beta precursor protein Rattus norvegicus 66-71 26442993-10 2015 E2 co-administration prevents Abeta-produced depletion of hippocampal somatostatin (SRIF) by an IGF-I-mediated mechanism, being related this protective effect with an increase in Abeta proteases. Estradiol 0-2 amyloid beta precursor protein Rattus norvegicus 30-35 26442993-10 2015 E2 co-administration prevents Abeta-produced depletion of hippocampal somatostatin (SRIF) by an IGF-I-mediated mechanism, being related this protective effect with an increase in Abeta proteases. Estradiol 0-2 amyloid beta precursor protein Rattus norvegicus 179-184 26442993-11 2015 Our results suggest that the E2-induced reduction in cell death is related to lower Abeta levels, probably because of SRIF modulation of Abeta proteases. Estradiol 29-31 amyloid beta precursor protein Rattus norvegicus 84-89 26442993-11 2015 Our results suggest that the E2-induced reduction in cell death is related to lower Abeta levels, probably because of SRIF modulation of Abeta proteases. Estradiol 29-31 amyloid beta precursor protein Rattus norvegicus 137-142 26213324-0 2015 HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17beta-estradiol production in granulosa cells. Estradiol 74-90 histone deacetylase 9 Homo sapiens 0-4 26253279-3 2015 17beta-estradiol and all tested parabens increased GPR30 gene and protein expression in MCF-7 and MCF-10A cells. Estradiol 0-16 G protein-coupled estrogen receptor 1 Homo sapiens 51-56 26242299-3 2015 OBJECTIVE: We sought to Determine the mechanism by which 17beta-estradiol (E2) and progesterone (P4) increase IL-17A production. Estradiol 57-73 interleukin 17A Homo sapiens 110-116 25776868-2 2015 Our previous studies demonstrated that estrogen- (17beta-estradiol; E2) mediated protection against experimental autoimmune encephalomyelitis (EAE), a mouse model for MS, hinges on the B cells, leading to elevated numbers of IL-10 secreting CD1d(hi)CD5(+) B regulatory cells (Bregs) in wild type mice. Estradiol 50-66 CD5 antigen Mus musculus 249-252 25463028-0 2015 Estradiol pretreatment ameliorates impaired synaptic plasticity at synapses of insulted CA1 neurons after transient global ischemia. Estradiol 0-9 carbonic anhydrase 1 Homo sapiens 88-91 25463028-7 2015 To our knowledge, our results are the first to demonstrate that estradiol at near physiological concentrations enhances basal excitatory synaptic transmission and ameliorates deficits in LTP at synapses onto CA1 neurons in a clinically-relevant model of global ischemia. Estradiol 64-73 carbonic anhydrase 1 Homo sapiens 208-211 25463028-9 2015 These findings support a model whereby estradiol acts via the IGF-1 receptor to maintain the functional integrity of hippocampal CA1 synapses in the face of global ischemia. Estradiol 39-48 carbonic anhydrase 1 Homo sapiens 129-132 26240989-3 2015 The present studies aimed to examine the effect of 17beta-estradiol (E2, the natural estrogen) on Glut3 expression and the underlying mechanisms by using human SH-SY5Y cell line. Estradiol 51-67 solute carrier family 2 member 3 Homo sapiens 98-103 26048717-2 2015 In the present study, to explore transcriptional activation and signaling pathways involved in PHB regulation in response to sex hormone treatment, we investigated the effects of estrogen (17-beta-estradiol, E2) on regulation of PHB in several metabolic tissues from male and female rats. Estradiol 189-206 prohibitin 1 Rattus norvegicus 229-232 26168035-5 2015 In the present study, we found that 17beta-estradiol (E2) suppresses nuclear factor-kappaB-dependent MMP-1b, MMP-2, MMP-3, MMP-9, MMP-10, and MMP-13 gene activation in microvessel endothelial bEnd.3 cells subjected to oxygen and glucose deprivation/reperfusion injury. Estradiol 36-52 matrix metallopeptidase 2 Mus musculus 109-114 26082062-0 2015 Estradiol suppresses neuronal firing activity and c-Fos expression in the lateral habenula. Estradiol 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 50-55 26015225-11 2015 17beta-estradiol (E2) up-regulates SOX4 expression in the absence of androgen through the formation of a protein complex between ERbeta and AR. Estradiol 0-16 SRY-box transcription factor 4 Homo sapiens 35-39 26289107-4 2015 METHODS: We performed primary culture of EECs and investigated the expression of OPN and MMP-9 in EECs regulated by 17beta-estradiol (E2). Estradiol 116-132 matrix metallopeptidase 9 Homo sapiens 89-94 26282993-15 2015 The knockdown of Nurr1 primarily elevated the synthesis of estradiol and partially attenuated the miR-132-induced estradiol elevation, and the ectopic expression of Flag-Nurr1 abrogated the stimulatory effect of miR-132 on estradiol synthesis in mouse GCs. Estradiol 59-68 nuclear receptor subfamily 4, group A, member 2 Mus musculus 17-22 26282993-15 2015 The knockdown of Nurr1 primarily elevated the synthesis of estradiol and partially attenuated the miR-132-induced estradiol elevation, and the ectopic expression of Flag-Nurr1 abrogated the stimulatory effect of miR-132 on estradiol synthesis in mouse GCs. Estradiol 114-123 nuclear receptor subfamily 4, group A, member 2 Mus musculus 17-22 26062636-0 2015 Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1. Estradiol 0-9 solute carrier family 7 member 1 Homo sapiens 115-148 26062636-12 2015 While estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK, progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation, an effect that predominates over estradiol. Estradiol 6-15 solute carrier family 7 member 1 Homo sapiens 49-54 25912736-0 2015 17beta-Estradiol enhances the activation of IFN-alpha signaling in B cells by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p that target IKKepsilon. Estradiol 0-16 interferon alpha Mus musculus 44-53 25912736-5 2015 Moreover, we found that 17beta-estradiol could enhance the activation of IFN-alpha signaling in an ERalpha-dependent manner by down-regulating the expression of three microRNAs, including let-7e-5p, miR-98-5p and miR-145a-5p. Estradiol 24-40 interferon alpha Mus musculus 73-82 25912736-9 2015 These data suggest that 17beta-estradiol amplifies the activation of IFN-alpha signaling in B cells via IKKepsilon by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Estradiol 24-40 interferon alpha Mus musculus 69-78 25960318-1 2015 Celecoxib has been reported to switch the human SULT2A1-catalyzed sulfonation of 17beta-estradiol (17beta-E2) from the 3- to the 17-position. Estradiol 81-97 sulfotransferase family 2A member 1 Homo sapiens 48-55 26225773-5 2015 Our results show that 17beta-estradiol (E2) and the selective ligand of GPER, namely G-1, induce the expression of SIRT1 through GPER and the subsequent activation of the EGFR/ERK/c-fos/AP-1 transduction pathway. Estradiol 22-38 G protein-coupled estrogen receptor 1 Homo sapiens 72-76 26225773-5 2015 Our results show that 17beta-estradiol (E2) and the selective ligand of GPER, namely G-1, induce the expression of SIRT1 through GPER and the subsequent activation of the EGFR/ERK/c-fos/AP-1 transduction pathway. Estradiol 22-38 sirtuin 1 Homo sapiens 115-120 26225773-5 2015 Our results show that 17beta-estradiol (E2) and the selective ligand of GPER, namely G-1, induce the expression of SIRT1 through GPER and the subsequent activation of the EGFR/ERK/c-fos/AP-1 transduction pathway. Estradiol 22-38 G protein-coupled estrogen receptor 1 Homo sapiens 129-133 26225773-5 2015 Our results show that 17beta-estradiol (E2) and the selective ligand of GPER, namely G-1, induce the expression of SIRT1 through GPER and the subsequent activation of the EGFR/ERK/c-fos/AP-1 transduction pathway. Estradiol 22-38 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 180-185 25627546-0 2015 Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARalpha Activation. Estradiol 0-9 intercellular adhesion molecule 1 Homo sapiens 61-67 25942073-8 2015 A similar reduction in the expression levels of the final steps of ovarian steroidogenesis, accompanied by reduced plasma estradiol levels, was observed in female UCN2-COE animals. Estradiol 122-131 urocortin 2 Mus musculus 163-167 25649128-0 2015 17beta-Estradiol Abrogates Apoptosis Inhibiting PKCdelta, JNK, and p66Shc Activation in C2C12 Cells. Estradiol 0-16 protein kinase C, delta Mus musculus 48-56 25649128-0 2015 17beta-Estradiol Abrogates Apoptosis Inhibiting PKCdelta, JNK, and p66Shc Activation in C2C12 Cells. Estradiol 0-16 mitogen-activated protein kinase 8 Mus musculus 58-61 25649128-0 2015 17beta-Estradiol Abrogates Apoptosis Inhibiting PKCdelta, JNK, and p66Shc Activation in C2C12 Cells. Estradiol 0-16 src homology 2 domain-containing transforming protein C1 Mus musculus 67-73 26030000-4 2015 Here, we demonstrate that in SkBr3 breast cancer and HepG2 hepatocarcinoma cells, 17beta-estradiol (E2) and the selective GPER ligand G-1 induce miR144 expression through GPER and the involvement of the PI3K/ERK1/2/Elk1 transduction pathway. Estradiol 82-98 G protein-coupled estrogen receptor 1 Homo sapiens 171-175 26030000-4 2015 Here, we demonstrate that in SkBr3 breast cancer and HepG2 hepatocarcinoma cells, 17beta-estradiol (E2) and the selective GPER ligand G-1 induce miR144 expression through GPER and the involvement of the PI3K/ERK1/2/Elk1 transduction pathway. Estradiol 82-98 ETS transcription factor ELK1 Homo sapiens 215-219 26124709-2 2015 An aggregate of HSD2-containing neurons is located laterally in the hypothalamus, and the numbers of these neurons were greatly increased by estradiol treatment in ovariectomized (OVX) rats compared to numbers in male rats and in OVX rats that were not given estradiol. Estradiol 141-150 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 16-20 26124709-2 2015 An aggregate of HSD2-containing neurons is located laterally in the hypothalamus, and the numbers of these neurons were greatly increased by estradiol treatment in ovariectomized (OVX) rats compared to numbers in male rats and in OVX rats that were not given estradiol. Estradiol 259-268 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 16-20 25340263-2 2015 We have previously shown that 17beta-estradiol at 10 nmol/l, a nearly identical plasma concentration to that during mid-pregnancy, up-regulates RAGE expression in endothelial cells. Estradiol 30-46 long intergenic non-protein coding RNA 914 Homo sapiens 144-148 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. Estradiol 11-27 long intergenic non-protein coding RNA 914 Homo sapiens 38-42 25730107-3 2015 Estradiol induces kisspeptin expression in the neurons of the rostral periventricular area of the third ventricle but suppresses kisspeptin expression in neurons of the arcuate nucleus that regulate estrogen-negative feedback. Estradiol 0-9 KiSS-1 metastasis-suppressor Mus musculus 18-28 25730107-3 2015 Estradiol induces kisspeptin expression in the neurons of the rostral periventricular area of the third ventricle but suppresses kisspeptin expression in neurons of the arcuate nucleus that regulate estrogen-negative feedback. Estradiol 0-9 KiSS-1 metastasis-suppressor Mus musculus 129-139 25730107-6 2015 As with kisspeptin neurons in vivo, 17beta-estradiol (E2) induced kisspeptin and PR in mHypoA51s. Estradiol 36-52 KiSS-1 metastasis-suppressor Mus musculus 8-18 25730107-6 2015 As with kisspeptin neurons in vivo, 17beta-estradiol (E2) induced kisspeptin and PR in mHypoA51s. Estradiol 36-52 KiSS-1 metastasis-suppressor Mus musculus 66-76 25730107-6 2015 As with kisspeptin neurons in vivo, 17beta-estradiol (E2) induced kisspeptin and PR in mHypoA51s. Estradiol 36-52 progesterone receptor Mus musculus 81-83 25910568-9 2015 Regulation of miR-21-5p and miR-21-3p, in human granulosa-like tumor (KGN) cells, by estradiol (E2), was tested in vitro. Estradiol 85-94 microRNA 215 Homo sapiens 14-23 25413376-6 2015 In addition, we show that 17beta-oestradiol induces the ERK1/2 activation and increases c-Fos expression through GPR30 associated with ERbeta down-regulation in TCam-2 cell line. Estradiol 26-43 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 88-93 25413376-6 2015 In addition, we show that 17beta-oestradiol induces the ERK1/2 activation and increases c-Fos expression through GPR30 associated with ERbeta down-regulation in TCam-2 cell line. Estradiol 26-43 G protein-coupled estrogen receptor 1 Homo sapiens 113-118 25818184-0 2015 The role of 17beta-estradiol in the regulation of antioxidant enzymes via the Nrf2-Keap1 pathway in the livers of CBA/H mice. Estradiol 12-28 kelch-like ECH-associated protein 1 Mus musculus 83-88 25818184-1 2015 AIMS: We aimed to explore the impact of surgical 17beta-estradiol (E2) deprivation/administration on the expression of antioxidant enzymes with an emphasis on the alteration of the NF-E2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) pathway under physiological conditions in the livers of CBA/H mice of both sexes. Estradiol 49-65 kelch-like ECH-associated protein 1 Mus musculus 246-251 25818184-1 2015 AIMS: We aimed to explore the impact of surgical 17beta-estradiol (E2) deprivation/administration on the expression of antioxidant enzymes with an emphasis on the alteration of the NF-E2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) pathway under physiological conditions in the livers of CBA/H mice of both sexes. Estradiol 67-69 kelch-like ECH-associated protein 1 Mus musculus 246-251 25810326-0 2015 Estradiol modulates visceral hyperalgesia by increasing thoracolumbar spinal GluN2B subunit activity in female rats. Estradiol 0-9 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 77-83 25810326-3 2015 METHODS: Behavioral, molecular, and immunocytochemical techniques were used to determine spinal GluN2B expression/phosphorylation and function 48 h following subcutaneous injection of estradiol (E2) or vehicle (safflower oil, Saff oil) in ovariectomized rats in the absence or presence of colonic inflammation induced by mustard oil. Estradiol 184-193 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 96-102 26022099-0 2015 17beta-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells. Estradiol 0-16 stearoyl-CoA desaturase Homo sapiens 25-50 26022099-10 2015 RESULTS: 17beta-estradiol significantly induced cell proliferation and SCD-1 activity in MCF-7 and T47D cells but not MCF-10A cells. Estradiol 9-25 stearoyl-CoA desaturase Homo sapiens 71-76 26022099-11 2015 Accordingly, 17beta-estradiol significantly increased SCD-1 mRNA and protein expression in MCF-7 and T47D cells compared to untreated cells. Estradiol 13-29 stearoyl-CoA desaturase Homo sapiens 54-59 26022099-12 2015 Treatment of MCF-7 cells with 4-OH tamoxifen or siRNA silencing of estrogen receptor-alpha largely prevented 17beta-estradiol-induced SCD-1 expression. Estradiol 109-125 stearoyl-CoA desaturase Homo sapiens 134-139 26022099-14 2015 The selective SCD-1 inhibitor or siRNA silencing of SCD-1 blocked the 17beta-estradiol-induced cell proliferation and increase in cellular MUFA/SFA ratios. Estradiol 70-86 stearoyl-CoA desaturase Homo sapiens 14-19 26022099-14 2015 The selective SCD-1 inhibitor or siRNA silencing of SCD-1 blocked the 17beta-estradiol-induced cell proliferation and increase in cellular MUFA/SFA ratios. Estradiol 70-86 stearoyl-CoA desaturase Homo sapiens 52-57 26022099-16 2015 The IGF-1R antagonist partially blocked 17beta-estradiol-induced cell proliferation and SCD-1 expression, suggesting the impact of 17beta-estradiol on SCD-1 expression is partially mediated though IGF-1R signaling. Estradiol 47-56 insulin like growth factor 1 receptor Homo sapiens 4-10 26022099-16 2015 The IGF-1R antagonist partially blocked 17beta-estradiol-induced cell proliferation and SCD-1 expression, suggesting the impact of 17beta-estradiol on SCD-1 expression is partially mediated though IGF-1R signaling. Estradiol 47-56 insulin like growth factor 1 receptor Homo sapiens 197-203 26022099-16 2015 The IGF-1R antagonist partially blocked 17beta-estradiol-induced cell proliferation and SCD-1 expression, suggesting the impact of 17beta-estradiol on SCD-1 expression is partially mediated though IGF-1R signaling. Estradiol 40-56 insulin like growth factor 1 receptor Homo sapiens 4-10 26022099-16 2015 The IGF-1R antagonist partially blocked 17beta-estradiol-induced cell proliferation and SCD-1 expression, suggesting the impact of 17beta-estradiol on SCD-1 expression is partially mediated though IGF-1R signaling. Estradiol 40-56 stearoyl-CoA desaturase Homo sapiens 88-93 26022099-16 2015 The IGF-1R antagonist partially blocked 17beta-estradiol-induced cell proliferation and SCD-1 expression, suggesting the impact of 17beta-estradiol on SCD-1 expression is partially mediated though IGF-1R signaling. Estradiol 40-56 stearoyl-CoA desaturase Homo sapiens 151-156 26022099-16 2015 The IGF-1R antagonist partially blocked 17beta-estradiol-induced cell proliferation and SCD-1 expression, suggesting the impact of 17beta-estradiol on SCD-1 expression is partially mediated though IGF-1R signaling. Estradiol 40-56 insulin like growth factor 1 receptor Homo sapiens 197-203 25847233-7 2015 GPER/GPR30 co-immunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin, or G-1. Estradiol 74-90 G protein-coupled estrogen receptor 1 Homo sapiens 0-4 25847233-7 2015 GPER/GPR30 co-immunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin, or G-1. Estradiol 74-90 G protein-coupled estrogen receptor 1 Homo sapiens 5-10 25701401-10 2015 Estradiol-17beta treatment increased the Mc3r promoter activity, indicating that the gene is regulated by estradiol-17beta. Estradiol 0-16 melanocortin 3 receptor Mus musculus 41-45 25701401-10 2015 Estradiol-17beta treatment increased the Mc3r promoter activity, indicating that the gene is regulated by estradiol-17beta. Estradiol 106-122 melanocortin 3 receptor Mus musculus 41-45 25805499-5 2015 Using live-cell imaging with fluorescent protein labeling, we found that only ERRbeta among the ERRs exhibits a punctate intranuclear pattern overlapping with ERalpha following 17beta-estradiol (E2)-stimulation. Estradiol 177-193 estrogen related receptor beta Homo sapiens 78-85 25694484-7 2015 These data suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II-induced hypertension, in preventing oxidative stress, and in increasing activity of antioxidant systems, most likely via generation of 2-methoxyestradiol from 17beta-estradiol. Estradiol 311-327 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 24-30 25130479-2 2015 Reverse transcription polymerase chain reaction (RT-PCR) studies showed that 10 nM estradiol enhanced MLL transcription in addition to its common translocation partners, MLLT2 (AF4) and MLLT3 (AF9). Estradiol 83-92 AF4/FMR2 family member 1 Homo sapiens 170-175 25130479-2 2015 Reverse transcription polymerase chain reaction (RT-PCR) studies showed that 10 nM estradiol enhanced MLL transcription in addition to its common translocation partners, MLLT2 (AF4) and MLLT3 (AF9). Estradiol 83-92 AF4/FMR2 family member 1 Homo sapiens 177-180 25928008-0 2015 Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. Estradiol 0-9 G protein-coupled estrogen receptor 1 Homo sapiens 36-40 25686467-10 2015 Mechanistic investigation revealed that PCBs suppress hepcidin transcription through a functional ERE within the hepcidin promoter, analogous to the action of 17beta-estradiol. Estradiol 159-175 hepcidin antimicrobial peptide Mus musculus 54-62 25611593-6 2015 RESULTS: In this study, we report that GluA1 surface expression and phosphorylation induced by 17beta-estradiol (E2) were impaired in the Fmr1 KO neurons. Estradiol 95-111 fragile X messenger ribonucleoprotein 1 Mus musculus 138-142 25675114-2 2015 We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy. Estradiol 39-55 ATP binding cassette subfamily B member 11 Homo sapiens 99-103 25675114-2 2015 We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy. Estradiol 39-55 ATP binding cassette subfamily B member 11 Homo sapiens 219-223 25675114-2 2015 We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy. Estradiol 39-55 cystatin 12, pseudogene Homo sapiens 227-237 25739982-7 2015 Rapamycin suppressed 17beta-estradiol-induced Sertoli cell proliferation, appearing to act by reducing the abundance of SKP2, CCND1, and CCNE1 mRNA as well as RB and EMI1 protein. Estradiol 21-37 cyclin E1 Homo sapiens 137-142 25796089-3 2015 Our studies show that pharmacological activation of the hindbrain energy sensor AMPK by AICAR elicits estradiol (E)-dependent patterns of Fos immunolabeling of hypothalamic metabolic loci. Estradiol 102-111 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 138-141 25576195-0 2015 17beta-estradiol protects against apoptosis induced by interleukin-1beta in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13. Estradiol 0-16 matrix metallopeptidase 3 Rattus norvegicus 122-127 25576195-0 2015 17beta-estradiol protects against apoptosis induced by interleukin-1beta in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13. Estradiol 0-16 matrix metallopeptidase 13 Rattus norvegicus 132-138 24777823-0 2015 Progesterone, as well as 17beta-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus. Estradiol 25-41 aryl hydrocarbon receptor Rattus norvegicus 71-74 24777823-3 2015 In a previous study, we could already demonstrate the regulation of many members of the AHR battery by 17beta-estradiol (E2) in the uterus of rats. Estradiol 103-119 aryl hydrocarbon receptor Rattus norvegicus 88-91 25545386-2 2015 It has been proposed that estradiol (E2) activation of ERalpha in kisspeptin neurons in the arcuate nucleus (ARC) suppresses GnRH/LH secretion (negative feedback), whereas E2 activation of ERalpha in kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) mediates the release of preovulatory GnRH/LH surges (positive feedback). Estradiol 26-35 KiSS-1 metastasis-suppressor Mus musculus 66-76 25738143-3 2015 The present study is an attempt to correlate the CXCR4/SDF1 expression patterns with clinicopathological factors, patient survival, and its coexistence and response to 17-beta estradiol (E2) and 4-hydoxytamoxifen (4OHT) in breast cancer cells. Estradiol 168-185 C-X-C motif chemokine receptor 4 Homo sapiens 49-54 25738143-3 2015 The present study is an attempt to correlate the CXCR4/SDF1 expression patterns with clinicopathological factors, patient survival, and its coexistence and response to 17-beta estradiol (E2) and 4-hydoxytamoxifen (4OHT) in breast cancer cells. Estradiol 187-189 C-X-C motif chemokine receptor 4 Homo sapiens 49-54 24469035-7 2015 Inhibition of IGF1R or phosphoinositide 3-kinase blocked PR-B-dependent CTSD mRNA upregulation in response to estradiol. Estradiol 110-119 insulin like growth factor 1 receptor Homo sapiens 14-19 25280774-0 2015 17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha. Estradiol 0-17 apoptosis inducing factor mitochondria associated 1 Homo sapiens 68-71 25280774-7 2015 The results showed 17beta estradiol (E2) protected MCF7 cells from PARP1-dependent cell death by decreasing protein PARylation, and AIF translocation into nuclei/nucleoli. Estradiol 19-35 apoptosis inducing factor mitochondria associated 1 Homo sapiens 132-135 25612679-4 2015 The testosterone (TE) aromatization in estradiol (E2) was indirectly evaluated in terms of inhibition of TE-induced cell proliferation, ERalpha phosphorylation/activation and Bcl-2 and IGF-1R ERE-regulated protein accumulation. Estradiol 39-48 insulin like growth factor 1 receptor Homo sapiens 185-191 25411391-5 2015 Addition of FGF18 decreased abundance of mRNA encoding the antiapoptotic proteins GADD45B and MDM2, and increased that encoding the proapoptotic protein BBC3; these effects were reversed by coculture with estradiol. Estradiol 205-214 growth arrest and DNA damage inducible beta Bos taurus 82-89 25411391-5 2015 Addition of FGF18 decreased abundance of mRNA encoding the antiapoptotic proteins GADD45B and MDM2, and increased that encoding the proapoptotic protein BBC3; these effects were reversed by coculture with estradiol. Estradiol 205-214 MDM2 proto-oncogene Bos taurus 94-98 25315223-10 2015 These results suggested that FSH functions via p38 MAPK-induced dephosphorylation at Ser(727) of STAT1 to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles. Estradiol 154-163 signal transducer and activator of transcription 1 Mus musculus 97-102 25612870-3 2015 The gonadal steroid 17beta-estradiol (E2) upregulates not only kisspeptin (Kiss1) mRNA but also increases the excitability of the rostral forebrain Kiss1 neurons. Estradiol 20-36 KiSS-1 metastasis suppressor Homo sapiens 75-80 25612870-3 2015 The gonadal steroid 17beta-estradiol (E2) upregulates not only kisspeptin (Kiss1) mRNA but also increases the excitability of the rostral forebrain Kiss1 neurons. Estradiol 20-36 KiSS-1 metastasis suppressor Homo sapiens 148-153 25518000-8 2014 However, the number of Ym1-positive cells as an anti-inflammatory M2-like macrophage marker in the PM OVX+17beta-estradiol group was significantly higher than those in the other three groups. Estradiol 106-122 chitinase-like 3 Mus musculus 23-26 25496649-0 2014 Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17beta-estradiol. Estradiol 101-117 G protein-coupled estrogen receptor 1 Homo sapiens 14-19 25496649-3 2014 We have recently shown that knock-down of GPR30 expression prevented growth stimulation of TNBC cell lines by 17beta-estradiol. Estradiol 110-126 G protein-coupled estrogen receptor 1 Homo sapiens 42-47 25496649-20 2014 17beta-estradiol increased CREB-phosphorylation to 400%. Estradiol 0-16 cAMP responsive element binding protein 1 Homo sapiens 27-31 25247469-10 2014 Finally, we found that NVT Kiss1 neurons drastically change their neuronal activities according to the reproductive state and the estradiol levels. Estradiol 130-139 metastasis-suppressor KiSS-1 Oryzias latipes 27-32 25256868-2 2014 We investigated whether the attenuated hypertrophic effect of oestradiol was via activation of phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) through non-genomic action. Estradiol 62-72 nitric oxide synthase 3 Rattus norvegicus 171-175 25256868-5 2014 The phosphorylation of Akt and eNOS was significantly decreased in infarcted rats and restored by oestradiol and G-1, implying the GPER pathway in this process. Estradiol 98-108 nitric oxide synthase 3 Rattus norvegicus 31-35 25256868-11 2014 The specific PI3K inhibitor, LY290042, completely abolished Akt activation and eNOS phosphorylation in infarcted hearts treated with either oestradiol or oestradiol + G-15. Estradiol 140-150 nitric oxide synthase 3 Rattus norvegicus 79-83 25258388-12 2014 pulses, s.c. oestrogenic supplementation (with E2, PPT or DPN) consistently decreased (by -46, -48 and -41% respectively) the Pitx1 mRNA in the anterior pituitary gland. Estradiol 47-49 paired-like homeodomain 1 Rattus norvegicus 126-131 25138705-7 2014 In ovariectomised mice, exogenous oestradiol administration increased mammary gland CSF1, CSF2, IFNG and LIF, compared with ovariectomised control mice. Estradiol 34-44 colony stimulating factor 1 (macrophage) Mus musculus 84-88 25138705-7 2014 In ovariectomised mice, exogenous oestradiol administration increased mammary gland CSF1, CSF2, IFNG and LIF, compared with ovariectomised control mice. Estradiol 34-44 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 90-94 25138705-8 2014 Progesterone administration together with oestradiol resulted in reduced CSF1, CSF3 and IFNG compared with oestradiol administration alone. Estradiol 42-52 colony stimulating factor 1 (macrophage) Mus musculus 73-77 25469035-14 2014 In addition, 17beta-estradiol and/or ER agonists dramatically inhibited cell migration and reduced the expression of u-PA, t-PA and MMP-9 as well as MMP-2/9 activity in LoVo cells, which regulate cell metastasis. Estradiol 13-29 matrix metallopeptidase 9 Homo sapiens 132-137 25299774-1 2014 Recently, we reported that human neuroglobin (NGB) is a new player in the signal transduction pathways that lead to 17beta-estradiol (E2)-induced neuron survival. Estradiol 116-132 neuroglobin Homo sapiens 33-44 25299774-1 2014 Recently, we reported that human neuroglobin (NGB) is a new player in the signal transduction pathways that lead to 17beta-estradiol (E2)-induced neuron survival. Estradiol 116-132 neuroglobin Homo sapiens 46-49 25088689-4 2014 Estrogen receptors (ERs) and ER coregulators such as mixed lineage leukemia (MLL) histone methylases (MLL2 and MLL3) and histone acetyltransferase CBP/P300 bind to the EZH2 promoter in the presence of estradiol and regulate estradiol-induced EZH2 expression. Estradiol 224-233 CREB binding protein Rattus norvegicus 147-155 25151950-3 2014 The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Estradiol 116-125 acid phosphatase 5, tartrate resistant Rattus norvegicus 61-65 25056967-0 2014 Transcriptional regulation of the sodium-coupled neutral amino acid transporter (SNAT2) by 17beta-estradiol. Estradiol 91-107 solute carrier family 38 member 2 Homo sapiens 81-86 25056967-2 2014 It is known that SNAT2 expression increases during pregnancy, and in vitro studies indicate that this transporter is induced by 17beta-estradiol. Estradiol 128-144 solute carrier family 38 member 2 Homo sapiens 17-22 24869908-4 2014 Here we show that overexpression of PDZK1 promoted an increase in cyclin D1 and enhanced anchorage-independent growth of MCF-7 cells in the absence of 17beta-estradiol, suggesting that PDZK1 harbors oncogenic activity. Estradiol 151-167 PDZ domain containing 1 Homo sapiens 36-41 24846172-6 2014 Recently we have cloned and characterized a murine claudin-5 promoter and demonstrated 17beta-estradiol (E2)-mediated regulation of claudin-5 in brain and heart microvascular endothelium on promoter, mRNA and protein level. Estradiol 87-103 claudin 5 Mus musculus 51-60 24846172-6 2014 Recently we have cloned and characterized a murine claudin-5 promoter and demonstrated 17beta-estradiol (E2)-mediated regulation of claudin-5 in brain and heart microvascular endothelium on promoter, mRNA and protein level. Estradiol 87-103 claudin 5 Mus musculus 132-141 24731011-0 2014 Serum estradiol associates with blood hemoglobin in elderly men: the MrOS Sweden study. Estradiol 6-15 MROS Homo sapiens 69-73 24728488-10 2014 In particular, UGT5A5, UGT5B2, and UGT5E1 glucuronidate phenols and steroids with high specificity toward steroid hormones of estradiol and testosterone and estrogenic alkylphenols 4-tert-octylphenol. Estradiol 126-135 UDP glucuronosyltransferase 5 family, polypeptide B2 Danio rerio 23-29 24831183-0 2014 Estradiol ameliorates the reduction in parvalbumin expression induced by ischemic brain injury. Estradiol 0-9 parvalbumin Rattus norvegicus 39-50 24831183-4 2014 This study investigated whether estradiol modulates parvalbumin expression in focal cerebral ischemia and glutamate-induced neuronal cell death. Estradiol 32-41 parvalbumin Rattus norvegicus 52-63 24831183-8 2014 Reverse transcription-PCR and Western blot analyses confirmed that estradiol treatment attenuated the MCAO-induced decrease in parvalbumin levels. Estradiol 67-76 parvalbumin Rattus norvegicus 127-138 24831183-11 2014 Moreover, estradiol prevented the decrease in parvalbumin induced by glutamate toxicity. Estradiol 10-19 parvalbumin Rattus norvegicus 46-57 24813109-5 2014 17beta-estradiol (E2) treatment ameliorated depression-like behavior and increased BDNF level in hippocampus in OVX rats. Estradiol 0-16 brain-derived neurotrophic factor Rattus norvegicus 83-87 24813109-5 2014 17beta-estradiol (E2) treatment ameliorated depression-like behavior and increased BDNF level in hippocampus in OVX rats. Estradiol 18-20 brain-derived neurotrophic factor Rattus norvegicus 83-87 24680884-6 2014 In this paper, we show that the estrogen receptors, GPR30 and ERalpha, were present in VSNs and that estradiol may be synthesized locally in the VNO. Estradiol 101-110 G protein-coupled estrogen receptor 1 Mus musculus 52-57 24681828-0 2014 Estradiol stimulates mitochondrial biogenesis and adiponectin expression in skeletal muscle. Estradiol 0-9 adiponectin, C1Q and collagen domain containing Rattus norvegicus 50-61 23735658-2 2014 Interestingly, Sprr2a mRNA is detected in the mouse uterus and is regulated by 17beta-oestradiol (E2). Estradiol 79-96 small proline-rich protein 2A1 Mus musculus 15-21 24516177-0 2014 PARP1 during embryo implantation and its upregulation by oestradiol in mice. Estradiol 57-67 poly (ADP-ribose) polymerase family, member 1 Mus musculus 0-5 24830702-6 2014 In the ovariectomized mouse uterus, the expression of Kiss1 mRNA was upregulated after progesterone or/and estradiol treatment. Estradiol 107-116 KiSS-1 metastasis-suppressor Mus musculus 54-59 24671882-7 2014 In cultured bovine granulosa cells, human recombinant CHEMERIN (hRec, 200 ng/ml) reduced production of both progesterone and estradiol, cholesterol content, STAR abundance, CYP19A1 and HMGCR proteins, and the phosphorylation levels of MAPK3/MAPK1 in the presence or absence of FSH (10(-8) M) and IGF1 (10(-8) M). Estradiol 125-134 retinoic acid receptor responder 2 Homo sapiens 54-62 24446390-10 2014 Small interfering RNA targeting GPER or G protein inhibitor pertussin toxin (PTX) inhibited basal cell proliferation and attenuated 17beta-estradiol- or G-1-induced cell proliferation. Estradiol 132-148 G protein-coupled estrogen receptor 1 Homo sapiens 32-36 24617524-4 2014 Estradiol priming significantly increased Kiss1r, Nr1, and Nr2b receptor transcript and protein abundance in young but not middle-aged female hypothalamus. Estradiol 0-9 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 59-63 24758297-6 2014 GATA3 turn-over in response to hormone was determined by treating the cells with estradiol or ERalpha agonist, ICI 182,780. Estradiol 81-90 GATA binding protein 3 Homo sapiens 0-5 24361909-3 2014 Because alterations in Brain-Derived Neurotrophic Factor (BDNF) and monoamine levels in the hippocampus and amygdala have been associated with anxiety disorders, we hypothesized that chronic treatment with a low dose of estradiol would cause anxiety-like disorder by altering BDNF and monoamine levels in these regions. Estradiol 220-229 brain derived neurotrophic factor Homo sapiens 23-56 24361909-3 2014 Because alterations in Brain-Derived Neurotrophic Factor (BDNF) and monoamine levels in the hippocampus and amygdala have been associated with anxiety disorders, we hypothesized that chronic treatment with a low dose of estradiol would cause anxiety-like disorder by altering BDNF and monoamine levels in these regions. Estradiol 220-229 brain derived neurotrophic factor Homo sapiens 58-62 24361909-3 2014 Because alterations in Brain-Derived Neurotrophic Factor (BDNF) and monoamine levels in the hippocampus and amygdala have been associated with anxiety disorders, we hypothesized that chronic treatment with a low dose of estradiol would cause anxiety-like disorder by altering BDNF and monoamine levels in these regions. Estradiol 220-229 brain derived neurotrophic factor Homo sapiens 276-280 24473434-0 2014 Estradiol modulates Kiss1 neuronal response to ghrelin. Estradiol 0-9 KiSS-1 metastasis-suppressor Mus musculus 20-25 24473434-8 2014 Increased colocalization was observed in ARC Kiss1 neurons of ovariectomized estradiol-treated (OVX + E2; 80%) compared with ovariectomized oil-treated (OVX; 25%) mice. Estradiol 77-86 KiSS-1 metastasis-suppressor Mus musculus 45-50 24473434-9 2014 Acute actions of ghrelin on ARC Kiss1 neurons were also modulated by estradiol; 75 and 22% of Kiss1 neurons of OVX + E2 and OVX mice, respectively, depolarized in response to ghrelin. Estradiol 69-78 KiSS-1 metastasis-suppressor Mus musculus 94-99 24456507-8 2014 As a proof of concept for the exploitation of this resource, beta-estradiol-induced proliferation of root hairs, dark-induced senescence, anthocyanin accumulation and dwarfism were observed in lines conditionally expressing full-length cDNAs encoding RHD6, WRKY22, MYB123/TT2 and MYB26, respectively, in agreement with previously reported phenotypes conferred by these TFs. Estradiol 61-75 ROOT HAIR DEFECTIVE6 Arabidopsis thaliana 251-255 24456507-8 2014 As a proof of concept for the exploitation of this resource, beta-estradiol-induced proliferation of root hairs, dark-induced senescence, anthocyanin accumulation and dwarfism were observed in lines conditionally expressing full-length cDNAs encoding RHD6, WRKY22, MYB123/TT2 and MYB26, respectively, in agreement with previously reported phenotypes conferred by these TFs. Estradiol 61-75 myb domain protein 26 Arabidopsis thaliana 280-285 24269736-3 2014 This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid. Estradiol 53-55 agouti related neuropeptide Homo sapiens 77-81 24611062-4 2014 Here, we used acute rat hippocampal slices to analyze the mechanisms underlying rapid changes in mTOR activity and actin polymerization elicited by estradiol. Estradiol 148-157 mechanistic target of rapamycin kinase Rattus norvegicus 97-101 24239983-5 2014 Plasma membrane fractions prepared from whole kidney tissue or HEK293 cells expressing recombinant human GPER-1 (HEK-GPER-1) displayed high-affinity, specific [(3)H]-17beta-estradiol ([(3)H]-E2) binding, but no specific [(3)H]-aldosterone binding. Estradiol 166-182 G protein-coupled estrogen receptor 1 Homo sapiens 105-111 24239983-5 2014 Plasma membrane fractions prepared from whole kidney tissue or HEK293 cells expressing recombinant human GPER-1 (HEK-GPER-1) displayed high-affinity, specific [(3)H]-17beta-estradiol ([(3)H]-E2) binding, but no specific [(3)H]-aldosterone binding. Estradiol 166-182 G protein-coupled estrogen receptor 1 Homo sapiens 113-123 24382202-0 2014 Oestradiol alters central 5-HT1A receptor binding potential differences related to psychosocial stress but not differences related to 5-HTTLPR genotype in female rhesus monkeys. Estradiol 0-10 5-hydroxytryptamine receptor 1A Macaca mulatta 26-32 24280132-0 2014 Estradiol enhances CIP2A expression by the activation of p70 S6 kinase. Estradiol 0-9 cellular inhibitor of PP2A Homo sapiens 19-24 24121025-1 2014 The aim of the present study was to investigate the effects of different periods of ovariectomy and 17beta-estradiol (E2) replacement on the expression of Cytochrome C, apoptosis inducing factor (AIF) and Endonuclease-G (Endo-G) in mitochondrial and cytosolic fractions obtained from hippocampus of the adult female rats. Estradiol 100-116 apoptosis inducing factor, mitochondria associated 1 Rattus norvegicus 169-194 24121025-1 2014 The aim of the present study was to investigate the effects of different periods of ovariectomy and 17beta-estradiol (E2) replacement on the expression of Cytochrome C, apoptosis inducing factor (AIF) and Endonuclease-G (Endo-G) in mitochondrial and cytosolic fractions obtained from hippocampus of the adult female rats. Estradiol 100-116 apoptosis inducing factor, mitochondria associated 1 Rattus norvegicus 196-199 25135305-11 2014 Results indicated that 17beta-oestradiol and melatonin treatments were able to significantly decrease expression of pro-inflammatory cytokines, iNOS and HO-1 in the hippocampus when compared to non-treated animals. Estradiol 23-40 heme oxygenase 1 Rattus norvegicus 153-157 25135305-12 2014 A similar age- and long-term ovarian hormone depletion- related increase in GFAP was also attenuated after both melatonin and oestradiol treatments. Estradiol 126-136 glial fibrillary acidic protein Rattus norvegicus 76-80 24759004-9 2014 Progesterone did not affect the expression of both VE-cadherin and claudin-5 and estradiol-17beta also did not affect the VE-cadherin expression, but estradiol-17beta significantly decreased the claudin-5 expression. Estradiol 150-166 claudin 5 Mus musculus 195-204 24203062-0 2014 Short-term estradiol supplementation potentiates low-dose ghrelin action in the presence of GHRH or somatostatin in older women. Estradiol 11-20 somatostatin Homo sapiens 100-112 24292258-3 2014 We sought to elucidate whether RhoA activity regulates estradiol-induced fibrosis after infarction in ovariectomized female rats. Estradiol 55-64 ras homolog family member A Rattus norvegicus 31-35 24292258-7 2014 Estradiol treatment was associated with RhoA/Rho kinase inhibition evidenced by increased phosphorylation of RhoA and decreased phosphorylation of downstream factors including cofilin. Estradiol 0-9 ras homolog family member A Rattus norvegicus 40-44 24292258-7 2014 Estradiol treatment was associated with RhoA/Rho kinase inhibition evidenced by increased phosphorylation of RhoA and decreased phosphorylation of downstream factors including cofilin. Estradiol 0-9 ras homolog family member A Rattus norvegicus 109-113 24292258-12 2014 These results indicate that chronic use of estradiol after infarction attenuates cardiac fibrosis by inhibiting RhoA/ROCK/cofilin pathway, which is exerted through membrane ERalpha-mediated receptor mechanism. Estradiol 43-52 ras homolog family member A Rattus norvegicus 112-116 24055854-6 2014 17beta-Estradiol was used as the marker substrate to determine UGT1A1 activities. Estradiol 0-16 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 63-69 24685982-0 2014 Hypoxia-induced gene expression of aquaporin-4, cyclooxygenase-2 and hypoxia-inducible factor 1alpha in rat cortical astroglia is inhibited by 17beta-estradiol and progesterone. Estradiol 143-159 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 69-100 24821192-7 2014 We also hypothesized that estradiol increases coexpression of PR-OFQ/N and ORL-1-POMC in ARH neurons of ovariectomized rats. Estradiol 26-35 proopiomelanocortin Rattus norvegicus 81-85 24821192-10 2014 Estradiol was shown to upregulate ORL-1 and POMC expression in MPN-projecting ARH neurons. Estradiol 0-9 proopiomelanocortin Rattus norvegicus 44-48 23425349-8 2014 Only Sult1e1 and, surprisingly, Hsd17b7 expression was modulated with potentially opposite effects on oestradiol bioavailability. Estradiol 102-112 sulfotransferase family 1E, member 1 Mus musculus 5-12 24337478-2 2013 that progesterone regulates RANKL in an ex vivo microstructure model of the human breast, but dispute the suppression of estradiol on progesterone-stimulated RANKL expression. Estradiol 121-130 TNF superfamily member 11 Homo sapiens 158-163 24129577-4 2013 The amino acid sequence of Cdc34 contains an insertion distal to the active site that is absent in most other E2s, yet this acidic loop (named for its four invariably conserved acidic residues) is critical for Cdc34 function both in vitro and in vivo. Estradiol 110-113 cell division cycle 34, ubiqiutin conjugating enzyme Homo sapiens 27-32 23871778-3 2013 Activation of GPER by the natural ligand 17beta-estradiol (E2), and the specific agonist G1, was shown to inhibit lipid accumulation in 3T3-L1 cells, while such inhibition was reversed upon knockdown of GPER using specific siRNA. Estradiol 41-57 G protein-coupled estrogen receptor 1 Mus musculus 14-18 23871778-3 2013 Activation of GPER by the natural ligand 17beta-estradiol (E2), and the specific agonist G1, was shown to inhibit lipid accumulation in 3T3-L1 cells, while such inhibition was reversed upon knockdown of GPER using specific siRNA. Estradiol 41-57 G protein-coupled estrogen receptor 1 Mus musculus 203-207 24033289-1 2013 In the dorsal raphe nucleus, 17beta-estradiol (E2) increases the expression of the brain-specific, rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase-2 (Tph2). Estradiol 29-45 tryptophan hydroxylase 2 Homo sapiens 148-172 24033289-1 2013 In the dorsal raphe nucleus, 17beta-estradiol (E2) increases the expression of the brain-specific, rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase-2 (Tph2). Estradiol 29-45 tryptophan hydroxylase 2 Homo sapiens 174-178 24033289-11 2013 We illustrate a direct regulation of the TPH2 transcription by estradiol and ERbeta via a newly identified ERE half-site within the TPH2 promoter: (i) Estradiol- or an ERbeta agonist-induced TPH2 transcription was blocked by an ER antagonist, while (ii) membrane impermeable form of estradiol did not induce transcription. Estradiol 63-72 tryptophan hydroxylase 2 Homo sapiens 41-45 24033289-11 2013 We illustrate a direct regulation of the TPH2 transcription by estradiol and ERbeta via a newly identified ERE half-site within the TPH2 promoter: (i) Estradiol- or an ERbeta agonist-induced TPH2 transcription was blocked by an ER antagonist, while (ii) membrane impermeable form of estradiol did not induce transcription. Estradiol 283-292 tryptophan hydroxylase 2 Homo sapiens 41-45 23786880-5 2013 Pre-treatment with estradiol for 2 days, which causes a partial desensitization of 5-HT1A-R signaling, potentiated agonist-induced increases in SUMO1-5-HT1A-Rs in the hypothalamus of ovariectomized rats. Estradiol 19-28 small ubiquitin-like modifier 1 Rattus norvegicus 144-149 23856065-0 2013 CRH receptor antagonism reverses the effect of social subordination upon central GABAA receptor binding in estradiol-treated ovariectomized female rhesus monkeys. Estradiol 107-116 corticotropin releasing hormone Macaca mulatta 0-3 23932581-9 2013 17beta-Estradiol also increased the level of IGFBP-3 protein in MECs cultured on Matrigel in the presence of IGF-I. Estradiol 0-16 IGFI Bos taurus 109-114 24059981-0 2013 Estradiol prevents olfactory dysfunction induced by A-beta 25-35 injection in hippocampus. Estradiol 0-9 amyloid beta precursor protein Rattus norvegicus 52-58 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Estradiol 96-110 glutathione peroxidase 1 Homo sapiens 13-17 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Estradiol 96-110 glutathione peroxidase 1 Homo sapiens 195-199 24039907-10 2013 Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to beta-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Estradiol 96-110 glutathione peroxidase 1 Homo sapiens 282-286 24185279-6 2013 Gene expression alterations of IL-17 were assessed following challenge with testosterone and 17beta-estradiol under simulated inflammatory conditions (+-IL-1beta). Estradiol 93-109 interleukin 17A Homo sapiens 31-36 23810794-3 2013 In addition, we investigated the underlying mechanism(s) of BPA and RES in regulating the interaction between estrogen receptor alpha (ERalpha) and insulin-like growth factor-1 receptor (IGF-1R) signals, a non- genomic pathway induced by 17beta-estradiol (E2). Estradiol 238-254 insulin like growth factor 1 receptor Homo sapiens 148-185 23810794-3 2013 In addition, we investigated the underlying mechanism(s) of BPA and RES in regulating the interaction between estrogen receptor alpha (ERalpha) and insulin-like growth factor-1 receptor (IGF-1R) signals, a non- genomic pathway induced by 17beta-estradiol (E2). Estradiol 238-254 insulin like growth factor 1 receptor Homo sapiens 187-193 23820902-7 2013 In addition, estradiol (E2)-stimulated follicle growth and GC proliferation in preantral follicles was impaired in Pik3cd-null ovaries. Estradiol 13-22 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Mus musculus 115-121 23810756-0 2013 MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2. Estradiol 33-42 forkhead box L2 Homo sapiens 66-71 23810756-2 2013 In this study, a direct link between microRNA-133b (miR-133b) and Foxl2-mediated estradiol release in granulosa cells was established. Estradiol 81-90 forkhead box L2 Homo sapiens 66-71 23777599-0 2013 Stearoyl-CoA desaturase 1, elongase 6 and their fatty acid products and precursors are altered in ovariectomized rats with 17beta-estradiol and progesterone treatment. Estradiol 123-139 stearoyl-CoA desaturase Rattus norvegicus 0-25 23777599-5 2013 However, SCD1 protein was increased in rats treated with estradiol plus progesterone. Estradiol 57-66 stearoyl-CoA desaturase Rattus norvegicus 9-13 23526212-8 2013 Estradiol resulted in a marked reduction of Type IV collagen deposition in xenograft tumors, associated with 2-fold greater MMP2 concentrations compared with placebo-treated mice. Estradiol 0-9 matrix metallopeptidase 2 Mus musculus 124-128 23526212-10 2013 In vitro, estradiol enhanced MMP2 transcripts, protein accumulation, and activity. Estradiol 10-19 matrix metallopeptidase 2 Mus musculus 29-33 23526212-11 2013 These estradiol-induced changes in MMP2 were blocked by Faslodex. Estradiol 6-15 matrix metallopeptidase 2 Mus musculus 35-39 23526212-12 2013 In TSC2-deficient cells, estradiol increased MMP2 concentrations in vitro and in vivo, and induced extracellular matrix remodeling. Estradiol 25-34 matrix metallopeptidase 2 Mus musculus 45-49 23519266-10 2013 17beta-Oestradiol increased expression of both Tph1 and CYP1B1 in PAH-PASMCs, and Dfen and 17beta-oestradiol had synergistic effects on proliferation of PAH-PASMCs. Estradiol 0-17 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 56-62 23559188-12 2013 Sex was among the main determinants of the AUC of omentin-1 and leptin in linear regression models, and lower estradiol and testosterone concentrations were related to higher AUC of chemerin and omentin-1, respectively. Estradiol 110-119 retinoic acid receptor responder 2 Homo sapiens 182-190 23804103-0 2013 Estrous cycle plasticity in the hyperpolarization-activated current ih is mediated by circulating 17beta-estradiol in preoptic area kisspeptin neurons. Estradiol 98-114 KiSS-1 metastasis-suppressor Mus musculus 132-142 23804103-8 2013 Experiments in OVX mice given estradiol replacement identified an estradiol-dependent increase in Ih within RP3V kisspeptin neurons. Estradiol 30-39 KiSS-1 metastasis-suppressor Mus musculus 113-123 23804103-8 2013 Experiments in OVX mice given estradiol replacement identified an estradiol-dependent increase in Ih within RP3V kisspeptin neurons. Estradiol 66-75 KiSS-1 metastasis-suppressor Mus musculus 113-123 23643896-6 2013 Both estradiol and testosterone significantly increased the neural cell expression of cellular mature BDNF and BDNF mRNA. Estradiol 5-14 brain-derived neurotrophic factor Rattus norvegicus 102-106 23643896-6 2013 Both estradiol and testosterone significantly increased the neural cell expression of cellular mature BDNF and BDNF mRNA. Estradiol 5-14 brain-derived neurotrophic factor Rattus norvegicus 111-115 23079626-7 2013 In adult females, fluctuations in recognition memory following ovariectomy and estradiol replacement, during the estrous cycle, in pregnancy and with aging are accompanied by similar changes in circulating estradiol, BDNF levels and spine density alterations in the PFC and the hippocampus. Estradiol 79-88 brain derived neurotrophic factor Homo sapiens 217-221 23079626-9 2013 Moreover, estradiol increases BDNF levels through action on nuclear receptors. Estradiol 10-19 brain derived neurotrophic factor Homo sapiens 30-34 23211562-4 2013 However, links between sex hormones such as estradiol and testosterone, as well as endogenous and synthetic glucocorticoids (GCs), have emerged as important mediators of BDNF expression and function. Estradiol 44-53 brain derived neurotrophic factor Homo sapiens 170-174 23211562-5 2013 Examples of such regulation include brain region-specific induction of Bdnf mRNA in response to estradiol. Estradiol 96-105 brain derived neurotrophic factor Homo sapiens 71-75 23211562-6 2013 Additional studies have also documented regulation of the expression of the high-affinity BDNF receptor Tropomyosin-Related Kinase B by estradiol, thus implicating sex steroids not only in the regulation of BDNF expression, but also in mechanisms of signaling associated with it. Estradiol 136-145 brain derived neurotrophic factor Homo sapiens 90-94 23211562-6 2013 Additional studies have also documented regulation of the expression of the high-affinity BDNF receptor Tropomyosin-Related Kinase B by estradiol, thus implicating sex steroids not only in the regulation of BDNF expression, but also in mechanisms of signaling associated with it. Estradiol 136-145 brain derived neurotrophic factor Homo sapiens 207-211 23276673-6 2013 Then we consider the results of studies that suggest that 17beta-estradiol alters hippocampal function by its influence on BDNF expression in the MF pathway. Estradiol 58-74 brain derived neurotrophic factor Homo sapiens 123-127 23434684-0 2013 beta-Estradiol-dependent activation of the JAK/STAT pathway requires p/CIP and CARM1. Estradiol 0-14 coactivator associated arginine methyltransferase 1 Homo sapiens 79-84 23434684-3 2013 We have shown, using a ChIP-on-chip approach, that in response to stimulation with 17beta-estradiol (E2), the p/CIP/CARM1 complex is recruited to 204 proximal promoters in MCF-7 cells. Estradiol 83-99 coactivator associated arginine methyltransferase 1 Homo sapiens 116-121 23704881-5 2013 In MCF-7 cells, estradiol (E2) and IGF-I induced the rapid association of ER to IGF-IR, however, the interaction was abrogated in MCF-7(SX13) cells. Estradiol 16-25 insulin like growth factor 1 receptor Homo sapiens 80-86 23499826-3 2013 Estradiol enhanced BMP-4-induced Runx2, osterix, ALP and osteocalcin expression in MC3T3-E1 cells. Estradiol 0-9 Sp7 transcription factor 7 Mus musculus 40-47 23598402-7 2013 We show that overexpression of catalytically inactive E6AP-C843A in C/EBPalpha inducible K562- p42C/EBPalpha-estrogen receptor (ER) cells inhibits beta-estradiol (E2)-induced C/EBPalpha degradation leading to enhanced granulocytic differentiation. Estradiol 147-161 ubiquitin protein ligase E3A Homo sapiens 54-58 23415902-1 2013 Follicle-stimulating hormone (FSH) activates FSH receptors (FSHR) in granulosa cells to induce follicle differentiation, growth and estradiol production. Estradiol 132-141 follicle stimulating hormone receptor Homo sapiens 45-58 23395521-0 2013 17-beta Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice. Estradiol 0-17 low density lipoprotein receptor Mus musculus 128-132 23313114-6 2013 Treatment of bovine granulosa cells in vitro with BMP2 increased estradiol but decreased progesterone concentrations. Estradiol 65-74 bone morphogenetic protein 2 Bos taurus 50-54 23313114-7 2013 Co-incubation with CART reduced the BMP2-stimulated increase in granulosa cell estradiol production. Estradiol 79-88 bone morphogenetic protein 2 Bos taurus 36-40 23417422-9 2013 The percentage of estrogen receptor neurons containing Fos was significantly influenced in a brain region-, developmental stage-, and steroid-specific fashion by testosterone and E2 treatments. Estradiol 179-181 protein c-Fos Ovis aries 55-58 23419687-8 2013 Both drugs, estradiol and genistein, were able to reverse GLUT-3 downregulation in the cortex following late ovariectomy. Estradiol 12-21 solute carrier family 2 member 3 Rattus norvegicus 58-64 23549616-0 2013 Upregulation of SIRT1 by 17beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1. Estradiol 25-41 sirtuin 1 Homo sapiens 16-21 23549616-1 2013 17beta-estradiol (E2) treatment of cells results in an upregulation of SIRT1 and a down-regulation of PPARgamma. Estradiol 0-16 sirtuin 1 Homo sapiens 71-76 23259674-4 2013 Structural and biochemical analysis of the XIAP RING dimer shows that an aromatic residue at the dimer interface is required for E2~Ub binding and Ub transfer. Estradiol 129-131 X-linked inhibitor of apoptosis Homo sapiens 43-47 23376487-0 2013 Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels. Estradiol 106-115 brain-derived neurotrophic factor Rattus norvegicus 43-76 23376487-4 2013 We hypothesized that estradiol modulates Bdnf expression and the anorectic effect of BDNF. Estradiol 21-30 brain-derived neurotrophic factor Rattus norvegicus 41-45 23376487-4 2013 We hypothesized that estradiol modulates Bdnf expression and the anorectic effect of BDNF. Estradiol 21-30 brain-derived neurotrophic factor Rattus norvegicus 85-89 23376487-5 2013 The first goal was to determine whether Bdnf expression was regulated by endogenous estradiol of cycling rats and by cyclic estradiol treatment using ovariectomized rats. Estradiol 84-93 brain-derived neurotrophic factor Rattus norvegicus 40-44 23376487-8 2013 All of these alterations were reversed by cyclic estradiol treatment, suggesting that Bdnf expression within the VMH was regulated in an estradiol-dependent manner. Estradiol 49-58 brain-derived neurotrophic factor Rattus norvegicus 86-90 23376487-10 2013 Sham-operated estrous rats and ovariectomized rats cyclically treated with estradiol responded to a lower dose of central administration of BDNF to decrease food intake than male rats and oil-treated ovariectomized rats, implying that endogenous estradiol or cyclic estradiol replacement increased the sensitivity to anorectic effect of BDNF. Estradiol 75-84 brain-derived neurotrophic factor Rattus norvegicus 140-144 23376487-10 2013 Sham-operated estrous rats and ovariectomized rats cyclically treated with estradiol responded to a lower dose of central administration of BDNF to decrease food intake than male rats and oil-treated ovariectomized rats, implying that endogenous estradiol or cyclic estradiol replacement increased the sensitivity to anorectic effect of BDNF. Estradiol 75-84 brain-derived neurotrophic factor Rattus norvegicus 337-341 23376487-10 2013 Sham-operated estrous rats and ovariectomized rats cyclically treated with estradiol responded to a lower dose of central administration of BDNF to decrease food intake than male rats and oil-treated ovariectomized rats, implying that endogenous estradiol or cyclic estradiol replacement increased the sensitivity to anorectic effect of BDNF. Estradiol 246-255 brain-derived neurotrophic factor Rattus norvegicus 140-144 23376487-10 2013 Sham-operated estrous rats and ovariectomized rats cyclically treated with estradiol responded to a lower dose of central administration of BDNF to decrease food intake than male rats and oil-treated ovariectomized rats, implying that endogenous estradiol or cyclic estradiol replacement increased the sensitivity to anorectic effect of BDNF. Estradiol 246-255 brain-derived neurotrophic factor Rattus norvegicus 140-144 23300088-1 2013 The estrogen 17beta-estradiol (E2) modulates dendritic spine plasticity in the cornu ammonis 1 (CA1) region of the hippocampus, and GPR30 (G-protein coupled estrogen receptor 1 (GPER1)) is an estrogen-sensitive G-protein-coupled receptor (GPCR) that is expressed in the mammalian brain and in specific subregions that are responsive to E2, including the hippocampus. Estradiol 13-29 G protein-coupled estrogen receptor 1 Homo sapiens 139-176 23386682-2 2013 This work used an oestradiol-inducible system to overexpress the NAC transcription factor BdSWN5 in the monocot model Brachypodium distachyon. Estradiol 18-28 protein SOMBRERO Brachypodium distachyon 90-96 22749492-1 2013 This study investigated the contribution of the new G protein-coupled estrogen receptor 1 (GPER1) in neuroprotection by 17beta-estradiol in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson"s disease. Estradiol 120-136 G protein-coupled estrogen receptor 1 Mus musculus 52-89 22749492-1 2013 This study investigated the contribution of the new G protein-coupled estrogen receptor 1 (GPER1) in neuroprotection by 17beta-estradiol in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson"s disease. Estradiol 120-136 G protein-coupled estrogen receptor 1 Mus musculus 91-96 23429294-0 2013 Neuroglobin upregulation induced by 17beta-estradiol sequesters cytocrome c in the mitochondria preventing H2O2-induced apoptosis of neuroblastoma cells. Estradiol 36-52 neuroglobin Homo sapiens 0-11 23429294-1 2013 The sex steroid hormone 17beta-estradiol (E2) upregulates the levels of neuroglobin (NGB), a new neuroprotectant globin, to elicit its neuroprotective effect against H(2)O(2)-induced apoptosis. Estradiol 24-40 neuroglobin Homo sapiens 72-83 23429294-1 2013 The sex steroid hormone 17beta-estradiol (E2) upregulates the levels of neuroglobin (NGB), a new neuroprotectant globin, to elicit its neuroprotective effect against H(2)O(2)-induced apoptosis. Estradiol 24-40 neuroglobin Homo sapiens 85-88 23211559-9 2013 Post-stroke estradiol administration increased BrdU-labeled cells, nestin-positive cells, doublecortin (DCX)-positive cells and BrdU+/DCX+ cells in the ischemic ipsilateral SVZ at all time points (P<0.05). Estradiol 12-21 doublecortin Rattus norvegicus 90-102 23211559-9 2013 Post-stroke estradiol administration increased BrdU-labeled cells, nestin-positive cells, doublecortin (DCX)-positive cells and BrdU+/DCX+ cells in the ischemic ipsilateral SVZ at all time points (P<0.05). Estradiol 12-21 doublecortin Rattus norvegicus 104-107 23211559-9 2013 Post-stroke estradiol administration increased BrdU-labeled cells, nestin-positive cells, doublecortin (DCX)-positive cells and BrdU+/DCX+ cells in the ischemic ipsilateral SVZ at all time points (P<0.05). Estradiol 12-21 doublecortin Rattus norvegicus 134-137 23211559-10 2013 Treatment with estradiol also increased HIF-1alpha and VEGF protein levels in the ischemic ipsilateral SVZ at all time points examined (P<0.05). Estradiol 15-24 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 40-50 23211559-11 2013 These findings indicate that post-stroke estradiol administration promotes SVZ neurogenesis in rats, probably by increasing HIF-1alpha and VEGF protein expression. Estradiol 41-50 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 124-134 22837389-4 2013 The results showed that estradiol enhances CYP2A6, CYP2B6, and CYP3A4 expression, whereas progesterone induces CYP2A6, CYP2B6, CYP2C8, CYP3A4, and CYP3A5 expression. Estradiol 24-33 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 43-49 23264616-11 2013 Previous treatment with estradiol resulted in lasting increases in levels of IGF-I receptors and phosphorylation of ERK/MAPK, a downstream signaling molecule of both ERalpha and IGF-I receptors, and increased levels of the ERalpha-regulated protein, choline acetyltransferase. Estradiol 24-33 choline O-acetyltransferase Rattus norvegicus 250-275 23544495-0 2013 [Influence of pertussis toxin on GPER-mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17beta-estradiol in endometrial carcinoma cells]. Estradiol 129-145 G protein-coupled estrogen receptor 1 Homo sapiens 33-37 23544495-1 2013 OBJECTIVE: To investigate the influence of pertussis toxin (PTX) on G protein-coupled estrogen receptor (GPER)-mediated activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling activated by 17beta-estradiol (17beta-E2) in endometrial carcinoma cells. Estradiol 217-233 G protein-coupled estrogen receptor 1 Homo sapiens 68-103 23544495-1 2013 OBJECTIVE: To investigate the influence of pertussis toxin (PTX) on G protein-coupled estrogen receptor (GPER)-mediated activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling activated by 17beta-estradiol (17beta-E2) in endometrial carcinoma cells. Estradiol 217-233 G protein-coupled estrogen receptor 1 Homo sapiens 105-109 21636145-0 2013 17beta-Estradiol enhances the recruitment of bone marrow-derived endothelial progenitor cells into infarcted myocardium by inducing CXCR4 expression. Estradiol 0-16 chemokine (C-X-C motif) receptor 4 Mus musculus 132-137 23449330-5 2013 Then the kinetics of estradiol at 3-hydroxy position (E-3OH) and 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation by recombinant UGT1A1s as well as human and minipig liver microsomes were analyzed. Estradiol 21-30 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 135-141 23131142-1 2013 It has been previously demonstrated that the progesterone receptor gene is up-regulated in the sex accessory glands of pre-pubertal and adult male bovines after 17beta-oestradiol treatment. Estradiol 168-178 progesterone receptor Bos taurus 45-66 23131142-9 2013 Five out of 190 beef cattle and 26 out of 177 calves tested expressed the progesterone receptor gene above their respective CCalpha and they were classified as being suspected of 17beta-oestradiol treatment. Estradiol 186-196 progesterone receptor Bos taurus 74-95 22965452-0 2013 Estradiol-induced increase in novel object recognition requires hippocampal NR2B-containing NMDA receptors. Estradiol 0-9 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 76-80 22976040-9 2013 In COS-7 cells with heterologously expressed Kv2.1 channels, 17beta-estradiol also inhibits macroscopic currents of Kv2.1. Estradiol 61-77 potassium voltage-gated channel subfamily B member 1 Homo sapiens 45-50 22976040-9 2013 In COS-7 cells with heterologously expressed Kv2.1 channels, 17beta-estradiol also inhibits macroscopic currents of Kv2.1. Estradiol 61-77 potassium voltage-gated channel subfamily B member 1 Homo sapiens 116-121 23192982-2 2013 We demonstrated that human SR-B1 is transcriptionally activated by 17beta-estradiol (E2) in HEPG2 and JAR cells. Estradiol 67-83 scavenger receptor class B member 1 Homo sapiens 27-32 23581407-5 2013 It was found that in the presence of estradiol, prolactin inhibits prolidase activity and its down-stream signaling proteins: HIF-1alpha, mTOR, AKT and MAPK p-38, while in the absence of estradiol, an opposite effect was observed. Estradiol 37-46 peptidase D Homo sapiens 67-76 23033809-7 2013 Moreover, the expression of NOX4 and Poldip2 mRNA was higher in the thyroids of adult female rats, as well as in PCCL3 cells treated with 17beta-estradiol. Estradiol 138-154 NADPH oxidase 4 Rattus norvegicus 28-32 25509129-4 2013 In estradiol-treated oocytes, only the combined effects of growth hormone and theophylline stimulates the release of Ca2+ from intracellular stores, and that the release of Ca2+ is reduced by the use of an inhibitor of protein kinase C. In the presence of estradiol, an inhibitor of microtubule polymerization blocked the release of Ca2+ stimulated by the combined action of growth hormone and theophylline. Estradiol 256-265 carbonic anhydrase 2 Homo sapiens 173-176 25509129-4 2013 In estradiol-treated oocytes, only the combined effects of growth hormone and theophylline stimulates the release of Ca2+ from intracellular stores, and that the release of Ca2+ is reduced by the use of an inhibitor of protein kinase C. In the presence of estradiol, an inhibitor of microtubule polymerization blocked the release of Ca2+ stimulated by the combined action of growth hormone and theophylline. Estradiol 256-265 carbonic anhydrase 2 Homo sapiens 173-176 23143558-4 2012 In this study, we first evaluated the effects of estradiol (E2) and its antagonist ICI182,780 on the expression of miRNAs (miR-31, miR-155 and miR-135b) using COLO205, SW480 and MCF-7 cell lines, followed by examining the association of tissue miRNA expression and serum E2 levels using samples collected from 18 colorectal cancer patients. Estradiol 49-58 microRNA 155 Homo sapiens 131-138 23143558-4 2012 In this study, we first evaluated the effects of estradiol (E2) and its antagonist ICI182,780 on the expression of miRNAs (miR-31, miR-155 and miR-135b) using COLO205, SW480 and MCF-7 cell lines, followed by examining the association of tissue miRNA expression and serum E2 levels using samples collected from 18 colorectal cancer patients. Estradiol 49-58 microRNA 135b Homo sapiens 143-151 23041085-8 2012 The assay using the luciferase reporter system confirmed the existence of a functional ERE in the hepcidin promoter, as the estradiol treatment reduced hepcidin expression in cells transfected with ERE-intact construct, with no response to estradiol in cells transfected with ERE-devoid construct. Estradiol 124-133 hepcidin antimicrobial peptide Mus musculus 98-106 23041085-8 2012 The assay using the luciferase reporter system confirmed the existence of a functional ERE in the hepcidin promoter, as the estradiol treatment reduced hepcidin expression in cells transfected with ERE-intact construct, with no response to estradiol in cells transfected with ERE-devoid construct. Estradiol 124-133 hepcidin antimicrobial peptide Mus musculus 152-160 23070546-6 2012 This effect was completely blocked by BZA as were E(2)-stimulated expression of PR, pS2 (trefoil factor 1), cMyc, and AREG; the enhancement of Ki67 and proliferating cell nuclear antigen (PCNA); and the antiapoptotic effect. Estradiol 50-54 antigen identified by monoclonal antibody Ki 67 Mus musculus 143-147 23070546-6 2012 This effect was completely blocked by BZA as were E(2)-stimulated expression of PR, pS2 (trefoil factor 1), cMyc, and AREG; the enhancement of Ki67 and proliferating cell nuclear antigen (PCNA); and the antiapoptotic effect. Estradiol 50-54 proliferating cell nuclear antigen Mus musculus 188-192 23041523-6 2012 Estradiol benzoate (E2) recovered OPG expression to the level comparable to the sham while that of RANKL was suppressed in ovariectomized mice. Estradiol 20-22 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 34-37 23032400-4 2012 However, the expression levels of Kir6.2 and SUR1 in brain cortices of ovariectomized rats recovered after supplementation with 17beta-estradiol. Estradiol 128-144 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 34-40 22648071-10 2012 Furthermore, bilirubin and beta-estradiol, probe substrates for UGT1A1, significantly inhibited the formation of puerarin-7-O-glucuronide in HLMs. Estradiol 27-41 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 64-70 22824300-8 2012 All these effects were not found in cells pre-treated with ICI 182,780, save for the changes in mfn-1, conferring them the effects of 17beta-estradiol to estrogen receptor. Estradiol 134-150 mitofusin 1 Homo sapiens 96-101 22377968-2 2012 However, it is unknown if 17beta-estradiol (E(2)) treatment is sufficient to inhibit cell proliferation and cell migration in human colon cancer cells. Estradiol 26-42 cystatin 12, pseudogene Homo sapiens 44-48 21287573-10 2012 OE also inhibits the action of 17beta-hydroxysteroid dehydrogenase, decreasing the synthesis of beta-estradiol and testosterone. Estradiol 96-110 aldo-keto reductase family 1, member C12 Rattus norvegicus 31-66