PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34289079-4	2021	Here, we show a mathematical modeling-guided approach to 3"-sialyllactose (3SL) synthesis from N-acetyl-D-neuraminic acid (Neu5Ac) and lactose in the presence of CTP, via the reactions of CMP-Neu5Ac synthetase and alpha2,3-sialyltransferase.	3'-sialyllactose	57-73	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	188-209
12613848-9	2003	Five sialyloligosaccharides were identified in bovine milk, of which 6"-sialyllactosamine and 3"-sialyllactose were the most abundant.	3'-sialyllactose	94-110	Weaning weight-maternal milk	Bos taurus	54-58
11117332-1	2000	The composition of the products formed by treatment of commercial alpha-Neu5Ac-(2 --> 3)-beta-D-Galp-(1 --> 4)-D-Glc (3"-sialyllactose) with glacial acetic acid was investigated by 1H-13C one- and two-dimensional NMR spectroscopy and fast atom bombardment-mass spectrometry.	3'-sialyllactose	124-140	galanin like peptide	Homo sapiens	99-103
9660955-0	1998	Crystal structure of the N-terminal domain of sialoadhesin in complex with 3" sialyllactose at 1.85 A resolution.	3'-sialyllactose	75-91	sialic acid binding Ig like lectin 1	Homo sapiens	46-58
8252532-5	1993	The usefulness of this analytical method was demonstrated using 3"-sialyllactose, i.e., alpha-Neu5Ac-(2-->3)-beta-D-Galp-(1-->4)-D-Glc.	3'-sialyllactose	64-80	galanin like peptide	Homo sapiens	119-123
3743024-3	1986	With the acceptor lactose, the major product (greater than 95%) for all samples is 3"-sialyllactose, suggesting that the elevated levels of sialyltransferase in 2-day-old calves are due to Gal-R (alpha 2-3) sialyltransferase.	3'-sialyllactose	83-99	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Bos taurus	189-224
33912037-7	2021	In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells.	3'-sialyllactose	13-18	prostaglandin-endoperoxide synthase 2	Homo sapiens	146-162
3896152-6	1985	Antisera specific for LS-tetrasaccharide c and 3"-sialyllactose (NeuAc alpha 2-3Gal beta 1-4Glc) identify their corresponding 3H-labeled haptens released from the major meconium gangliosides 6"-LM1 and GM3, respectively.	3'-sialyllactose	47-63	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	84-90
33912037-0	2021	3"-Sialyllactose Protects SW1353 Chondrocytic Cells From Interleukin-1beta-Induced Oxidative Stress and Inflammation.	3'-sialyllactose	0-16	interleukin 1 beta	Homo sapiens	57-74
33912037-7	2021	In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells.	3'-sialyllactose	13-18	interleukin 1 alpha	Homo sapiens	164-172
33912037-5	2021	3"-SL potently suppressed IL-1beta-induced oxidative stress by increasing the levels of enzymatic antioxidants.	3'-sialyllactose	0-5	interleukin 1 alpha	Homo sapiens	26-34
33912037-7	2021	In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells.	3'-sialyllactose	13-18	interleukin 6	Homo sapiens	178-182
33912037-7	2021	In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells.	3'-sialyllactose	13-18	cystatin 12, pseudogene	Homo sapiens	109-144
33912037-7	2021	In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells.	3'-sialyllactose	13-18	interleukin 1 alpha	Homo sapiens	186-194
33912037-8	2021	Moreover, 3"-SL significantly inhibited the apoptotic process, as indicated by the downregulation of the pro-apoptotic protein Bax, upregulation of the anti-apoptotic protein Bcl-2 expression, and significant reduction in the number of TUNEL-positive cells in the IL-1beta-treated chondrocytic cells.	3'-sialyllactose	10-15	BCL2 associated X, apoptosis regulator	Homo sapiens	127-130
33912037-8	2021	Moreover, 3"-SL significantly inhibited the apoptotic process, as indicated by the downregulation of the pro-apoptotic protein Bax, upregulation of the anti-apoptotic protein Bcl-2 expression, and significant reduction in the number of TUNEL-positive cells in the IL-1beta-treated chondrocytic cells.	3'-sialyllactose	10-15	BCL2 apoptosis regulator	Homo sapiens	175-180
33912037-8	2021	Moreover, 3"-SL significantly inhibited the apoptotic process, as indicated by the downregulation of the pro-apoptotic protein Bax, upregulation of the anti-apoptotic protein Bcl-2 expression, and significant reduction in the number of TUNEL-positive cells in the IL-1beta-treated chondrocytic cells.	3'-sialyllactose	10-15	interleukin 1 alpha	Homo sapiens	264-272
31852463-11	2019	Positive correlations of B4GALT1, LALBA, ST3GAL5, and ST6GAL1 with 3"-SL/6"SL and DSL were found.	3'-sialyllactose	67-72	beta-1,4-galactosyltransferase 1	Capra hircus	25-32
32722157-9	2020	In non-secretors, third trimester fasting plasma glucose and insulin were negatively associated with total HMO-bound sialic acid and concentrations of the sialylated HMOs 3"-sialyllactose and disialylacto-N-tetraose.	3'-sialyllactose	171-187	insulin	Homo sapiens	61-68
31852463-11	2019	Positive correlations of B4GALT1, LALBA, ST3GAL5, and ST6GAL1 with 3"-SL/6"SL and DSL were found.	3'-sialyllactose	67-72	alpha-lactalbumin	Capra hircus	34-39
31852463-11	2019	Positive correlations of B4GALT1, LALBA, ST3GAL5, and ST6GAL1 with 3"-SL/6"SL and DSL were found.	3'-sialyllactose	67-72	beta-galactoside alpha-2,6-sialyltransferase 1	Capra hircus	54-61
30152858-0	2018	3"-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis.	3'-sialyllactose	0-16	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	36-39
30152858-9	2018	Notably, phosphorylation of p65, which is a key protein in the NF-kappaB signalling pathway, was totally blocked by 3"-SL in the RA models.	3'-sialyllactose	116-121	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	28-31
29281012-0	2018	Induction of human tolerogenic dendritic cells by 3"-sialyllactose via TLR4 is explained by LPS contamination.	3'-sialyllactose	50-66	toll like receptor 4	Homo sapiens	71-75
29745223-6	2018	The biosynthesis of these was in direct competition with 3"-sialyllactose, the most abundant BMO in bovine milk.	3'-sialyllactose	57-73	Weaning weight-maternal milk	Bos taurus	107-111
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	collagen, type II, alpha 1	Mus musculus	138-144
28782172-7	2018	Our results strongly suggest that 3"-sialyllactose may ameliorate osteoarthritic cartilage destruction by cartilage regeneration via promoting Col2a1 production and may inhibit cartilage degradation and inflammation by suppressing Mmp3, Mmp13 and Cox2 expression.	3'-sialyllactose	34-50	matrix metallopeptidase 3	Mus musculus	231-235
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	matrix metallopeptidase 3	Mus musculus	295-299
28782172-7	2018	Our results strongly suggest that 3"-sialyllactose may ameliorate osteoarthritic cartilage destruction by cartilage regeneration via promoting Col2a1 production and may inhibit cartilage degradation and inflammation by suppressing Mmp3, Mmp13 and Cox2 expression.	3'-sialyllactose	34-50	matrix metallopeptidase 13	Mus musculus	237-242
28782172-7	2018	Our results strongly suggest that 3"-sialyllactose may ameliorate osteoarthritic cartilage destruction by cartilage regeneration via promoting Col2a1 production and may inhibit cartilage degradation and inflammation by suppressing Mmp3, Mmp13 and Cox2 expression.	3'-sialyllactose	34-50	cytochrome c oxidase II, mitochondrial	Mus musculus	247-251
28782172-8	2018	The effects of 3"-sialyllactose could be attributed in part to its regulation of Sox9 or NF-kappaB and inhibition of Erk phosphorylation and IkappaB degradation.	3'-sialyllactose	15-31	SRY (sex determining region Y)-box 9	Mus musculus	81-85
28782172-8	2018	The effects of 3"-sialyllactose could be attributed in part to its regulation of Sox9 or NF-kappaB and inhibition of Erk phosphorylation and IkappaB degradation.	3'-sialyllactose	15-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
28782172-8	2018	The effects of 3"-sialyllactose could be attributed in part to its regulation of Sox9 or NF-kappaB and inhibition of Erk phosphorylation and IkappaB degradation.	3'-sialyllactose	15-31	mitogen-activated protein kinase 1	Mus musculus	117-120
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	matrix metallopeptidase 13	Mus musculus	301-306
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	cytochrome c oxidase II, mitochondrial	Mus musculus	311-315
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	interleukin 1 beta	Mus musculus	327-335
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	interleukin 6	Mus musculus	337-341
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	interleukin 17A	Mus musculus	343-348
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	tumor necrosis factor	Mus musculus	353-362
28782172-5	2018	Additionally, IL-1beta induction of Erk phosphorylation and IkappaB degradation, representing a critical signal pathway for osteoarthritic development, was totally blocked by 3"-sialyllactose in a dose-dependent manner.	3'-sialyllactose	175-191	interleukin 1 beta	Mus musculus	14-22
28782172-5	2018	Additionally, IL-1beta induction of Erk phosphorylation and IkappaB degradation, representing a critical signal pathway for osteoarthritic development, was totally blocked by 3"-sialyllactose in a dose-dependent manner.	3'-sialyllactose	175-191	mitogen-activated protein kinase 1	Mus musculus	36-39
28782172-7	2018	Our results strongly suggest that 3"-sialyllactose may ameliorate osteoarthritic cartilage destruction by cartilage regeneration via promoting Col2a1 production and may inhibit cartilage degradation and inflammation by suppressing Mmp3, Mmp13 and Cox2 expression.	3'-sialyllactose	34-50	collagen, type II, alpha 1	Mus musculus	143-149
26697920-4	2016	In particular, 3"-sialyllactose significantly upregulate the expression of RUNX2 and ALP, well-known markers of osteogenesis, whereas 6"-sialyllactose up-regulate the expression of chondrocyte marker ACAN.	3'-sialyllactose	15-31	RUNX family transcription factor 2	Homo sapiens	75-80
26697920-4	2016	In particular, 3"-sialyllactose significantly upregulate the expression of RUNX2 and ALP, well-known markers of osteogenesis, whereas 6"-sialyllactose up-regulate the expression of chondrocyte marker ACAN.	3'-sialyllactose	15-31	ATHS	Homo sapiens	85-88
26432003-9	2016	Major substrate of medaka Neu1 was 3-sialyllactose and its optimal pH was 4.0.	3'-sialyllactose	35-50	sialidase-1	Oryzias latipes	26-30
26215345-6	2015	In trans-sialidase reactions, the P34H mutant displayed a distinct preference for 6"-sialyllactose synthesis but low levels of 3"-sialyllactose were also produced.	3'-sialyllactose	127-143	dicarbonyl and L-xylulose reductase	Homo sapiens	34-38
25601457-5	2015	All identified structures, except Neu5Ac(alpha2-3)Gal(beta1-4)Glc (3"-sialyllactose) contained Neu4,5Ac2 (4-O-acetyl-sialic acid).	3'-sialyllactose	67-83	sialidase-4	Ornithorhynchus anatinus	95-104
22894939-7	2012	The proportion of 3"-sialyllactose (3"-SL) per total HMOs was higher among transmitting than among nontransmitting women (P = 0.003) and correlated with higher plasma and breast-milk HIV RNA and lower CD4 counts.	3'-sialyllactose	18-34	CD4 molecule	Homo sapiens	201-204
22894939-7	2012	The proportion of 3"-sialyllactose (3"-SL) per total HMOs was higher among transmitting than among nontransmitting women (P = 0.003) and correlated with higher plasma and breast-milk HIV RNA and lower CD4 counts.	3'-sialyllactose	36-41	CD4 molecule	Homo sapiens	201-204
24554478-8	2014	The proinflammatory action of 3-sialyllactose was attributed on the one hand to the modulation of intestinal bacterial groups, and on the other hand to a direct stimulatory effect on CD11c+ dendritic cells.	3'-sialyllactose	30-45	integrin subunit alpha X	Homo sapiens	183-188
24140337-2	2013	In bovine milk, the majority of oligosaccharides are sialylated; 3"-sialyllactose (3"-N-acetylneuraminyl-D-lactose; 3"-SL) is the predominant sialylated oligosaccharide, followed by 6"-sialyllactose (6"-N-acetylneuraminyl-D-lactose; 6"-SL).	3'-sialyllactose	65-81	Weaning weight-maternal milk	Bos taurus	10-14
20114052-6	2010	The alpha-syn mutant E46K has a stronger affinity for GM3 than the wild-type protein, and the interaction is inhibited by 3"-sialyllactose (the glycone part of GM3).	3'-sialyllactose	122-138	synuclein alpha	Homo sapiens	4-13