PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30773296-7	2019	We observed that at equilibrium, single CaV1.342 channels occasionally switched from low to high open probability, which perhaps reflects occasional binding of CaM despite the presence of CTM.	CTMS	188-191	caveolin 1	Homo sapiens	40-44
30579200-2	2019	The CTM was validated for the present climatology, showing a good ability to represent air and soil concentrations of BaP over the target domain (petrochemical, chemical, urban and background sites), particularly in the winter.	CTMS	4-7	prohibitin 2	Homo sapiens	118-121
30881502-12	2019	Immunofluorescence staining for CD45 and P40 was a specific, accurate and convenient method for confirming the presence of CTCs or CTM in patients with ESCC, and is strongly recommended as a supplement to morphological analysis.	CTMS	131-134	protein tyrosine phosphatase receptor type C	Homo sapiens	32-36
30881502-12	2019	Immunofluorescence staining for CD45 and P40 was a specific, accurate and convenient method for confirming the presence of CTCs or CTM in patients with ESCC, and is strongly recommended as a supplement to morphological analysis.	CTMS	131-134	interleukin 9	Homo sapiens	41-44
30773296-10	2019	Our results suggest that the competition between CTM and CaM is influenced by calcium, allowing further fine-tuning of CaV1.3 channel activity for particular cellular needs.	CTMS	49-52	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	119-125
30355583-5	2018	Cav1.4Deltaex47 exhibits CDI and enhanced voltage-dependent activation, similar to that caused by a mutation that is associated with congenital stationary night blindness type 2, in which the CTM is deleted (K1591X).	CTMS	192-195	caveolin 1	Homo sapiens	0-4
28448959-11	2017	In stage IV patients, CTM positivity correlated with the CA125 level.	CTMS	22-25	mucin 16, cell surface associated	Homo sapiens	57-62
28448959-17	2017	CONCLUSIONS: In stage IV patients, CTM positivity was correlated with serum CA125 level.	CTMS	35-38	mucin 16, cell surface associated	Homo sapiens	76-81
29430076-6	2017	Our results indicate that tumor metastasis is more significantly associated with the presence of CTMs and M-CTCs than with other CTC subpopulations and suggest that EMT may be involved in CTC evasion of lymphocyte-mediated clearance.	CTMS	97-101	IL2 inducible T cell kinase	Homo sapiens	165-168
27187483-7	2016	Data from this report demonstrate the immunogenicity of the gp120 antigens, provide comprehensive characterization of the molecules, set the benchmark for assessment of current and future CTM lots, and lay the physicochemical groundwork for interpretation of future clinical trial data.	CTMS	188-191	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	60-65
27226626-6	2016	Exon 47 is crucial for these effects of the CTM because variants lacking this exon show intense CDI and activate at more hyperpolarized voltages than Cav1.4FL The robust CDI of Cav1.4Deltaex 47 is suppressed by CaBP4, a regulator of Cav1.4 channels in photoreceptors.	CTMS	44-47	calcium voltage-gated channel subunit alpha1 F	Homo sapiens	150-156
27226626-6	2016	Exon 47 is crucial for these effects of the CTM because variants lacking this exon show intense CDI and activate at more hyperpolarized voltages than Cav1.4FL The robust CDI of Cav1.4Deltaex 47 is suppressed by CaBP4, a regulator of Cav1.4 channels in photoreceptors.	CTMS	44-47	calcium voltage-gated channel subunit alpha1 F	Homo sapiens	177-183
27226626-6	2016	Exon 47 is crucial for these effects of the CTM because variants lacking this exon show intense CDI and activate at more hyperpolarized voltages than Cav1.4FL The robust CDI of Cav1.4Deltaex 47 is suppressed by CaBP4, a regulator of Cav1.4 channels in photoreceptors.	CTMS	44-47	calcium binding protein 4	Homo sapiens	211-216
27226626-6	2016	Exon 47 is crucial for these effects of the CTM because variants lacking this exon show intense CDI and activate at more hyperpolarized voltages than Cav1.4FL The robust CDI of Cav1.4Deltaex 47 is suppressed by CaBP4, a regulator of Cav1.4 channels in photoreceptors.	CTMS	44-47	calcium voltage-gated channel subunit alpha1 F	Homo sapiens	177-183
24703308-9	2014	However, the coupling efficiency was strengthened in the absence of the CTM in Cav1.342A, thereby shifting ICa-V by 7.2 mV to potentials that were more negative without changing QON-V. We independently show that the presence of intracellular organic cations (such as n-methyl-D-glucamine) induces a pronounced negative shift of QON-V and a more negative activation of ICa-V of all three channels.	CTMS	72-75	caveolin 1	Homo sapiens	79-83
24440306-6	2014	We then demonstrated that TopBP1"s C-terminal motif (designated as CTM, 23 amino acids) containing a putative NLS (nuclear localization signal) was required for Importin beta interaction and that CT100 of Importin beta (100 amino acids of extreme C-terminus of Importin beta) was required for TopBP1 interaction.	CTMS	67-70	DNA topoisomerase II binding protein 1 L homeolog	Xenopus laevis	26-32
24440306-11	2014	The requirement of TopBP1"s CTM motif for ATR-Chk1 checkpoint can be bypassed in a nucleus-free AT70 system.	CTMS	28-31	DNA topoisomerase II binding protein 1 L homeolog	Xenopus laevis	19-25
24440306-11	2014	The requirement of TopBP1"s CTM motif for ATR-Chk1 checkpoint can be bypassed in a nucleus-free AT70 system.	CTMS	28-31	ATR serine/threonine kinase L homeolog	Xenopus laevis	42-45
24440306-11	2014	The requirement of TopBP1"s CTM motif for ATR-Chk1 checkpoint can be bypassed in a nucleus-free AT70 system.	CTMS	28-31	checkpoint kinase 1 S homeolog	Xenopus laevis	46-50
24440306-12	2014	Taken together, our findings suggest that the CTM motif-mediated TopBP1 shuttling into nucleus via Importin beta plays an important role in the ATR-Chk1 checkpoint signaling in Xenopus egg extracts.	CTMS	46-49	DNA topoisomerase II binding protein 1 L homeolog	Xenopus laevis	65-71
24440306-12	2014	Taken together, our findings suggest that the CTM motif-mediated TopBP1 shuttling into nucleus via Importin beta plays an important role in the ATR-Chk1 checkpoint signaling in Xenopus egg extracts.	CTMS	46-49	ATR serine/threonine kinase L homeolog	Xenopus laevis	144-147
24440306-12	2014	Taken together, our findings suggest that the CTM motif-mediated TopBP1 shuttling into nucleus via Importin beta plays an important role in the ATR-Chk1 checkpoint signaling in Xenopus egg extracts.	CTMS	46-49	checkpoint kinase 1 S homeolog	Xenopus laevis	148-152
25411332-8	2015	Our numerical model demonstrated that CTM could potentiate occlusive events that drastically reduce blood flow and serve as a platform for the promotion of thrombin generation in flowing blood.	CTMS	38-41	coagulation factor II, thrombin	Homo sapiens	156-164
24703308-11	2014	Weak coupling of voltage sensing to pore opening is enhanced in the absence of the CTM, allowing short Cav1.342A splice variants to activate at lower voltages without affecting QON-V.	CTMS	83-86	caveolin 1	Homo sapiens	103-107
22760075-2	2012	A functional CTM is present in the long C-terminus of human and mouse Ca(v)1.3 (Ca(v)1.3(L)), but not in a rat long cDNA clone isolated from superior cervical ganglia neurons (rCa(v)1.3(scg)).	CTMS	13-16	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	70-78
24141197-6	2013	PrP mutations that increase TM1 hydrophobicity result in increased Ctm insertion, both in vitro and in mouse brain, and a strong correlation is found between CtmPrP insertion and neuropathology in transgenic mice; a copper-dependent pathogenicity mechanism is suggested.	CTMS	67-70	prion protein	Mus musculus	0-3
24141197-8	2013	However, secretion of PrP by the mammalian translocon requires the TRAP complex, absent in yeast, where essentially all PrP ends up as TM species, 85-90% Ntm and 10-15% Ctm.	CTMS	169-172	prion protein	Homo sapiens	22-25
22760075-2	2012	A functional CTM is present in the long C-terminus of human and mouse Ca(v)1.3 (Ca(v)1.3(L)), but not in a rat long cDNA clone isolated from superior cervical ganglia neurons (rCa(v)1.3(scg)).	CTMS	13-16	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	80-88
22760075-4	2012	When expressed in tsA-201 cells under identical experimental conditions rCa(v)1.3(L) exhibited Ca(2+) current properties indistinguishable from human and mouse Ca(v)1.3(L), compatible with the presence of a functional CTM.	CTMS	218-221	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	73-81
21126963-6	2011	Immunohistochemically, CTM is positive for LhS28, bcl-2, PAX2 and p16(INK4A).	CTMS	23-26	BCL2 apoptosis regulator	Homo sapiens	50-55
21126963-6	2011	Immunohistochemically, CTM is positive for LhS28, bcl-2, PAX2 and p16(INK4A).	CTMS	23-26	paired box 2	Homo sapiens	57-61
21126963-6	2011	Immunohistochemically, CTM is positive for LhS28, bcl-2, PAX2 and p16(INK4A).	CTMS	23-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	66-69
21126963-6	2011	Immunohistochemically, CTM is positive for LhS28, bcl-2, PAX2 and p16(INK4A).	CTMS	23-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-75
21298055-0	2011	Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.	CTMS	72-75	prion protein	Homo sapiens	24-27
21298055-0	2011	Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.	CTMS	72-75	prion protein	Homo sapiens	76-79
21298055-10	2011	CONCLUSIONS/SIGNIFICANCE: The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis.	CTMS	97-100	prion protein	Homo sapiens	66-69
21298055-10	2011	CONCLUSIONS/SIGNIFICANCE: The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis.	CTMS	97-100	prion protein	Homo sapiens	101-104
16326906-2	2006	Saturating cardiac tropomyosin (cTM) caused about a 20% increase in pyrene fluorescence of the doubly labeled F-actin but no change in WT actin C374 probe fluorescence.	CTMS	32-35	actin	Saccharomyces cerevisiae S288C	112-117
20385421-10	2010	CONCLUSIONS: Shortening the treatment duration to 16/24weeks can be performed on the basis of a RVR with HCV-RNA concentrations <15IU/ml by the CAP-CTM assay.	CTMS	151-154	nuclear receptor subfamily 1 group D member 2	Homo sapiens	96-99
16361698-5	2006	The CTM is indispensable for transcription via heat shock elements bound by a single Hsf1 trimer but is dispensable for transcription via heat shock elements bound by Hsf1 trimers in a cooperative manner.	CTMS	4-7	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	85-89
20980618-6	2010	Surprisingly, some human disease-causing mutants in PrP selectively stabilized (Ctm)PrP, revealing a previously unanticipated mechanism of (Ctm)PrP up-regulation that may contribute to disease.	CTMS	80-83	prion protein	Homo sapiens	52-55
20980618-6	2010	Surprisingly, some human disease-causing mutants in PrP selectively stabilized (Ctm)PrP, revealing a previously unanticipated mechanism of (Ctm)PrP up-regulation that may contribute to disease.	CTMS	80-83	prion protein	Homo sapiens	84-87
20980618-6	2010	Surprisingly, some human disease-causing mutants in PrP selectively stabilized (Ctm)PrP, revealing a previously unanticipated mechanism of (Ctm)PrP up-regulation that may contribute to disease.	CTMS	80-83	prion protein	Homo sapiens	84-87
20980618-6	2010	Surprisingly, some human disease-causing mutants in PrP selectively stabilized (Ctm)PrP, revealing a previously unanticipated mechanism of (Ctm)PrP up-regulation that may contribute to disease.	CTMS	140-143	prion protein	Homo sapiens	52-55
20980618-6	2010	Surprisingly, some human disease-causing mutants in PrP selectively stabilized (Ctm)PrP, revealing a previously unanticipated mechanism of (Ctm)PrP up-regulation that may contribute to disease.	CTMS	140-143	prion protein	Homo sapiens	84-87
20980618-6	2010	Surprisingly, some human disease-causing mutants in PrP selectively stabilized (Ctm)PrP, revealing a previously unanticipated mechanism of (Ctm)PrP up-regulation that may contribute to disease.	CTMS	140-143	prion protein	Homo sapiens	84-87
17325628-7	2007	NIH-3T3 fibroblast adhesion to fibronectin was enhanced by 4.7-fold with a 30 minute PureWay-CTM treatment while Ester-C increased fibroblast adhesion by only 1.5 fold.	CTMS	93-96	fibronectin 1	Rattus norvegicus	31-42
14750950-8	2003	CONCLUSIONS: These results show that CTM modulates activation function of AR2 in the Hsf1 molecule.	CTMS	37-40	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	85-89
35124127-5	2022	While knock-out of HIF-1alpha or therapeutically downregulating of HIF-1alpha via HIF-1alpha inhibitor (BAY87-2243)-loaded neutrophil cyto-pharmaceuticals (PNEs) could efficiently restrain CTM mediated lung metastasis.	CTMS	189-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
10791961-6	2000	Like apocytochrome c, but in contrast to holocytochrome c, Ctm lp is located in the cytosol, consistent with the view that the natural substrate is apocytochrome c. The ctm1-Delta strain lacking the methyltransferase did not exhibit any growth defect on a variety of media and growth conditions, and the unmethylated iso-1-cytochrome c was produced at the normal level and exhibited the normal activity in vivo.	CTMS	59-62	cytochrome c lysine N-methyltransferase	Saccharomyces cerevisiae S288C	169-173
10197796-10	1999	These results demonstrate that priming with 10 microg/kg G-CSF alone is well tolerated and effective in mobilizing sufficient numbers of CD34+ cells in breast cancer patients and provide prompt engraftment after CTM high-dose chemotherapy.	CTMS	212-215	colony stimulating factor 3	Homo sapiens	57-62
7734845-8	1994	Incorporation of labelled precursor (glucosamine) indicated that high-molecular-weight mucin glycoprotein was synthesized by these immortalized cells, which reacted with the antiserum to the native CTM.	CTMS	198-201	mucin	Canis lupus familiaris	87-92
7734845-9	1994	Equilibrium gradient centrifugation analysis showed that the buoyant density of the mucin synthesized in CT1 cells (1.486 g/ml) was similar to the reported value for native CTM (1.5 g/ml).	CTMS	173-176	LOC100508689	Homo sapiens	84-89
7734845-11	1994	These results suggest that CT1 cells synthesize a mucin glycoprotein which exhibits properties similar to native CTM.	CTMS	113-116	LOC100508689	Homo sapiens	50-55
35124127-5	2022	While knock-out of HIF-1alpha or therapeutically downregulating of HIF-1alpha via HIF-1alpha inhibitor (BAY87-2243)-loaded neutrophil cyto-pharmaceuticals (PNEs) could efficiently restrain CTM mediated lung metastasis.	CTMS	189-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-77
35124127-5	2022	While knock-out of HIF-1alpha or therapeutically downregulating of HIF-1alpha via HIF-1alpha inhibitor (BAY87-2243)-loaded neutrophil cyto-pharmaceuticals (PNEs) could efficiently restrain CTM mediated lung metastasis.	CTMS	189-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
35124127-8	2022	More importantly, we provide a promising strategy by targeted downregulation of HIF-1alpha in CTM via neutrophil cyto-pharmaceuticals for treatment of CTM mediated metastasis.	CTMS	94-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
35124127-8	2022	More importantly, we provide a promising strategy by targeted downregulation of HIF-1alpha in CTM via neutrophil cyto-pharmaceuticals for treatment of CTM mediated metastasis.	CTMS	151-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90