PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15062850-8	2004	Both Bt(2)cAMP, a permeable analogue of cAMP, and forskolin, which directly activates adenylate cyclase, also induced an increase in Tyr phosphorylation of p38 MAP kinase.	bt(2)	5-10	mitogen-activated protein kinase 14	Mus musculus	156-159
19244230-3	2009	Selective activation of Epac or PKA was achieved following exposure of INS-1 cells to 8-pCPT-2"-O-Me-cAMP-AM or Bt(2)cAMP-AM, respectively.	bt(2)	112-117	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	24-28
19244230-3	2009	Selective activation of Epac or PKA was achieved following exposure of INS-1 cells to 8-pCPT-2"-O-Me-cAMP-AM or Bt(2)cAMP-AM, respectively.	bt(2)	112-117	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	32-35
17875734-6	2007	Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways.	bt(2)	76-81	mitogen-activated protein kinase 14	Homo sapiens	128-131
17875734-6	2007	Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways.	bt(2)	76-81	mitogen-activated protein kinase 8	Homo sapiens	133-168
17875734-6	2007	Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways.	bt(2)	76-81	mitogen-activated protein kinase 1	Homo sapiens	174-211
17875734-6	2007	Here, we show that PGE(2) or its surrogate hormonal mixture dibutyryl cAMP (Bt(2)cAMP) + phorbol diacetate (PDA) stimulated the p38, c-jun NH(2)-terminal kinase (JNK)-1, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathways.	bt(2)	76-81	mitogen-activated protein kinase 1	Homo sapiens	213-216
16199882-4	2005	Bt(2)cAMP suppressed degradation of beta-catenin at the protein level.	bt(2)	0-5	catenin beta 1	Homo sapiens	36-48
18957421-11	2008	Differences between CREB binding to the two genes correlated with increasing methylation of the Wnt10b promoter following Bt(2)cAMP treatment, whereas no methylation of the cyclin D1 promoter was observed.	bt(2)	122-127	cAMP responsive element binding protein 1	Homo sapiens	20-24
18957421-11	2008	Differences between CREB binding to the two genes correlated with increasing methylation of the Wnt10b promoter following Bt(2)cAMP treatment, whereas no methylation of the cyclin D1 promoter was observed.	bt(2)	122-127	Wnt family member 10B	Homo sapiens	96-102
18514641-4	2008	More importantly, sucrose density gradient analysis revealed that both G(1) and G(4) AChE isoforms were increased in the Bt(2)-cAMP-treated cultures.	bt(2)	121-126	acetylcholinesterase	Rattus norvegicus	85-89
17875734-9	2007	PGE(2) or Bt(2)cAMP + PDA stimulated c-Jun and activating transcription factor-2 (ATF2) phosphorylation and binding to the PI.3/PII region.	bt(2)	10-15	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
17875734-9	2007	PGE(2) or Bt(2)cAMP + PDA stimulated c-Jun and activating transcription factor-2 (ATF2) phosphorylation and binding to the PI.3/PII region.	bt(2)	10-15	activating transcription factor 2	Homo sapiens	47-80
17875734-9	2007	PGE(2) or Bt(2)cAMP + PDA stimulated c-Jun and activating transcription factor-2 (ATF2) phosphorylation and binding to the PI.3/PII region.	bt(2)	10-15	activating transcription factor 2	Homo sapiens	82-86
11278499-6	2001	Dibutyryl cAMP (Bt(2)cAMP) stimulated the redistribution of AQP8 to plasma membranes.	bt(2)	16-21	aquaporin 8	Rattus norvegicus	60-64
12506119-5	2003	In transient-transfection studies, transcriptional activity of an hCYP17 promoter-reporter construct was increased by Bt(2)cAMP and by overexpression of PKA or MKP-1.	bt(2)	118-123	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	66-72
11278499-8	2001	The microtubule blocker colchicine but not its inactive analog lumicolchicine inhibited the Bt(2)cAMP effect on both AQP8 redistribution to cell surface and hepatocyte membrane water permeability.	bt(2)	92-97	aquaporin 8	Rattus norvegicus	117-121
10753877-10	2000	Human choriogonadotropin or Bt(2)cAMP treatment induced a stimulation of PDE activity in cells transfected with wild type PDE4D3, whereas the activation was absent in mutant- and control-transfected cells.	bt(2)	28-33	aldehyde dehydrogenase 7 family member A1	Homo sapiens	73-76
10715579-2	2000	This was monitored by loss of cell viability, increased DNA fragmentation, and activation of caspase-3-like activity, all of which were partially reversed by elevating the level of cAMP in the cells with Bt(2)cAMP or (Sp)cAMPS.	bt(2)	204-209	caspase 3	Gallus gallus	93-102
10531359-9	1999	The direct PKA activator, Bt(2)cAMP, caused concentration-dependent NO release and iNOS expression, as confirmed by immunofluorescence studies.	bt(2)	26-31	nitric oxide synthase 2	Homo sapiens	83-87
10559188-6	1999	NO donors and H89, an inhibitor of cAMP-dependent protein kinase increased, while dibutyryl cAMP (Bt(2)cAMP) decreased TNF-alpha promoter activity.	bt(2)	98-103	tumor necrosis factor	Homo sapiens	119-128