PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31374296-5	2019	Moreover, the PERK-eIF2alpha pathway was found as the main branch activated by TPT exposure in fish larvae.	triphenyltin	79-82	eukaryotic translation initiation factor 2-alpha kinase 3	Danio rerio	14-18
31606647-4	2019	In addition, TPT exposure significantly changed the expression levels of genes related to thyroid system, including corticotropin-releasing hormone gene crh, thyroid-stimulating hormone gene tshbeta, thyroglobulin gene tg, sodium/iodide symporter gene nis, thyroid hormone nuclear receptor tralpha, isoform trbeta, types I deiodinase gene dio1and types II deiodinase gene dio2.	triphenyltin	13-16	corticoliberin	Danio rerio	116-147
31606647-4	2019	In addition, TPT exposure significantly changed the expression levels of genes related to thyroid system, including corticotropin-releasing hormone gene crh, thyroid-stimulating hormone gene tshbeta, thyroglobulin gene tg, sodium/iodide symporter gene nis, thyroid hormone nuclear receptor tralpha, isoform trbeta, types I deiodinase gene dio1and types II deiodinase gene dio2.	triphenyltin	13-16	corticoliberin	Danio rerio	153-156
32173372-3	2020	The results showed that whole-body total T4 and T3 levels were significantly decreased, which was accompanied by the significant upregulation of the expression of the dio1, dio2 and ugt1ab genes after exposure to TPT for 7 and 14 days.	triphenyltin	213-216	iodothyronine deiodinase 1	Danio rerio	167-171
32173372-3	2020	The results showed that whole-body total T4 and T3 levels were significantly decreased, which was accompanied by the significant upregulation of the expression of the dio1, dio2 and ugt1ab genes after exposure to TPT for 7 and 14 days.	triphenyltin	213-216	iodothyronine deiodinase 2	Danio rerio	173-177
32173372-3	2020	The results showed that whole-body total T4 and T3 levels were significantly decreased, which was accompanied by the significant upregulation of the expression of the dio1, dio2 and ugt1ab genes after exposure to TPT for 7 and 14 days.	triphenyltin	213-216	UDP glucuronosyltransferase 1 family a, b	Danio rerio	182-188
31927052-0	2020	Tributyltin and triphenyltin induce 11beta-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor alpha.	triphenyltin	16-28	retinoid X receptor alpha	Homo sapiens	120-145
31927052-4	2020	The organotins tributyltin (TBT) and triphenyltin (TPT) induced 11beta-HSD2 expression and activity in JEG-3 placenta cells, an effect confirmed at the mRNA level in primary human trophoblast cells.	triphenyltin	37-49	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	64-75
31927052-4	2020	The organotins tributyltin (TBT) and triphenyltin (TPT) induced 11beta-HSD2 expression and activity in JEG-3 placenta cells, an effect confirmed at the mRNA level in primary human trophoblast cells.	triphenyltin	51-54	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	64-75
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	scavenger receptor class B, member 1	Rattus norvegicus	46-52
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	steroidogenic acute regulatory protein	Rattus norvegicus	54-58
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	60-67
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	69-75
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	cytochrome P450, family 21, subfamily a, polypeptide 1	Rattus norvegicus	77-82
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	84-91
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	97-104
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	170-175
31765896-7	2020	Triphenyltin down-regulated the expression of Scarb1, Star, Cyp11a1, Hsd3b1, Cyp21, Cyp11b1, and Hsd11b1 at 1 and/or 2 mg/kg while it up-regulated the expression of At1, Nr4a2, and Hsd11b2 at 2 mg/kg.	triphenyltin	0-12	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	181-188
31765896-8	2020	Triphenyltin activated the phosphorylation of AMPKalpha while suppressed the phosphorylation of AKT1 and SIRT1/PGC-1alpha in rat adrenals in vivo and H295R cells in vitro.	triphenyltin	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	96-100
31765896-8	2020	Triphenyltin activated the phosphorylation of AMPKalpha while suppressed the phosphorylation of AKT1 and SIRT1/PGC-1alpha in rat adrenals in vivo and H295R cells in vitro.	triphenyltin	0-12	sirtuin 1	Rattus norvegicus	105-110
31765896-8	2020	Triphenyltin activated the phosphorylation of AMPKalpha while suppressed the phosphorylation of AKT1 and SIRT1/PGC-1alpha in rat adrenals in vivo and H295R cells in vitro.	triphenyltin	0-12	PPARG coactivator 1 alpha	Rattus norvegicus	111-121
31765896-10	2020	In conclusion, triphenyltin disrupts glucocorticoid synthesis in rat adrenal cortex via several mechanisms: 1) lowering AKT1 phosphorylation and SIRT1/PGC-1alpha levels; 2) activating AMPKalpha; and 3) possibly inducing ROS production.	triphenyltin	15-27	AKT serine/threonine kinase 1	Rattus norvegicus	120-124
31765896-10	2020	In conclusion, triphenyltin disrupts glucocorticoid synthesis in rat adrenal cortex via several mechanisms: 1) lowering AKT1 phosphorylation and SIRT1/PGC-1alpha levels; 2) activating AMPKalpha; and 3) possibly inducing ROS production.	triphenyltin	15-27	sirtuin 1	Rattus norvegicus	145-150
31765896-10	2020	In conclusion, triphenyltin disrupts glucocorticoid synthesis in rat adrenal cortex via several mechanisms: 1) lowering AKT1 phosphorylation and SIRT1/PGC-1alpha levels; 2) activating AMPKalpha; and 3) possibly inducing ROS production.	triphenyltin	15-27	PPARG coactivator 1 alpha	Rattus norvegicus	151-161
31568941-6	2020	Therefore, parental exposure to TPT induces toxicity in fish offspring through perturbation of the HPT and GH/IGF axes.	triphenyltin	32-35	growth hormone 1	Danio rerio	107-109
31374296-5	2019	Moreover, the PERK-eIF2alpha pathway was found as the main branch activated by TPT exposure in fish larvae.	triphenyltin	79-82	eukaryotic translation initiation factor 2A	Danio rerio	19-28
30423510-8	2019	In addition, TPT-induced total antioxidant capacities, the activities of superoxide dismutase and catalase, and the contents of malondialdehyde in liver and intestinal tissues indicated increases in oxidative stress.	triphenyltin	13-16	catalase	Poecilia reticulata	98-106
28242277-2	2017	In embryo stage, TPT exposure could elevate the heartbeat rate at Day 6-8 post-fertilization and increase the expression levels of five heart development related genes (i.e., ATPase, COX2, BMP4, GATA4 and NKX2.5).	triphenyltin	17-20	COX2	Oryzias melastigma	183-187
30439410-4	2019	2-APB considerably attenuated the TPT-induced facilitation of sIPSC frequency while dantrolene almost completely masked the TPT effects, suggesting that the TPT-induced synaptic facilitation results from the activation of both IP3 and ryanodine receptors on endoplasmic reticulum (ER) membrane, though inositol triphosphate (IP3) receptor is less sensitive to TPT.	triphenyltin	34-37	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	325-338
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	48-53
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	scavenger receptor class B, member 1	Rattus norvegicus	55-61
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	steroidogenic acute regulatory protein	Rattus norvegicus	63-67
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	69-76
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	78-85
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	insulin-like 3	Rattus norvegicus	87-92
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	follicle stimulating hormone receptor	Rattus norvegicus	94-98
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	platelet derived growth factor subunit A	Rattus norvegicus	100-105
30223319-6	2018	Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above.	triphenyltin	0-12	SRY-box transcription factor 9	Rattus norvegicus	111-115
29621670-3	2018	The transcriptional activity of T. clavigera RXR-1 was also examined by using 9cRA and 16 organotin compounds, and significant ligand-dependent transactivations were observed by 9cRA and 5 organotins (tributyltin (TBT), tetrabutyltin (TeBT), tripropyltin (TPrT), tricyclohexyltin (TcHT) and triphenyltin (TPhT)).	triphenyltin	291-303	retinoid X receptor alpha	Homo sapiens	45-48
29621670-3	2018	The transcriptional activity of T. clavigera RXR-1 was also examined by using 9cRA and 16 organotin compounds, and significant ligand-dependent transactivations were observed by 9cRA and 5 organotins (tributyltin (TBT), tetrabutyltin (TeBT), tripropyltin (TPrT), tricyclohexyltin (TcHT) and triphenyltin (TPhT)).	triphenyltin	305-309	retinoid X receptor alpha	Homo sapiens	45-48
30609542-6	2019	Accurate mass measurements, isotope pattern fits and the structural information obtained by DESI-MS/HRMS (wide isolation window) allowed identifying the presence of triphenyltin, a biocide extensively used for agricultural purposes and restricted by the European Commission, in the phytosanitary product.	triphenyltin	165-177	desumoylating isopeptidase 2	Homo sapiens	92-96
29758877-0	2018	The role of ppargamma in embryonic development of Xenopus tropicalis under triphenyltin-induced teratogenicity.	triphenyltin	75-87	pparg	Xenopus tropicalis	12-21
29758877-1	2018	Evidence has shown that triphenyltin (TPT) triggers severe malformations in Xenopus tropicalis embryos, partly due to activation of PPARgamma (peroxisome proliferator activated receptor gamma) protein.	triphenyltin	24-36	pparg	Xenopus tropicalis	132-141
29758877-1	2018	Evidence has shown that triphenyltin (TPT) triggers severe malformations in Xenopus tropicalis embryos, partly due to activation of PPARgamma (peroxisome proliferator activated receptor gamma) protein.	triphenyltin	24-36	pparg	Xenopus tropicalis	143-191
29758877-1	2018	Evidence has shown that triphenyltin (TPT) triggers severe malformations in Xenopus tropicalis embryos, partly due to activation of PPARgamma (peroxisome proliferator activated receptor gamma) protein.	triphenyltin	38-41	pparg	Xenopus tropicalis	132-141
29758877-1	2018	Evidence has shown that triphenyltin (TPT) triggers severe malformations in Xenopus tropicalis embryos, partly due to activation of PPARgamma (peroxisome proliferator activated receptor gamma) protein.	triphenyltin	38-41	pparg	Xenopus tropicalis	143-191
29758877-7	2018	Meanwhile, microinjection of ppargamma MO combined with exposure to 20mugSn/L TPT caused 85% mortality.	triphenyltin	78-81	pparg	Xenopus tropicalis	29-38
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	42-54	retinoid X receptor alpha	Homo sapiens	157-176
28527383-4	2017	Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT enhancer binding protein alpha (C/EBPalpha) protein expression when compared to a control, both in the presence or absence of lipid mixture.	triphenyltin	28-31	peroxisome proliferator-activated receptor gamma	Oncorhynchus mykiss	81-129
28527383-4	2017	Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT enhancer binding protein alpha (C/EBPalpha) protein expression when compared to a control, both in the presence or absence of lipid mixture.	triphenyltin	28-31	peroxisome proliferator-activated receptor gamma	Oncorhynchus mykiss	131-140
28527383-4	2017	Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT enhancer binding protein alpha (C/EBPalpha) protein expression when compared to a control, both in the presence or absence of lipid mixture.	triphenyltin	28-31	CCAAT/enhancer binding protein alpha	Oncorhynchus mykiss	146-182
25985376-8	2015	We used a PPARgamma/RXRalpha C432A heterodimer to determine whether TBT and TPT could activate the heterodimer by binding to PPARgamma.	triphenyltin	76-79	peroxisome proliferator activated receptor gamma	Homo sapiens	125-134
25985376-9	2015	We found that TBT and TPT activated the PPARgamma/RXRalpha C432A heterodimer, which suggests that both compounds can activate the heterodimer through PPARgamma.	triphenyltin	22-25	peroxisome proliferator activated receptor gamma	Homo sapiens	40-49
27167774-1	2016	The trialkyltins tributyltin (TBT) and triphenyltin (TPT) can function as rexinoid-X receptor (RXR) agonists.	triphenyltin	39-51	retinoid X receptor alpha	Homo sapiens	95-98
27167774-1	2016	The trialkyltins tributyltin (TBT) and triphenyltin (TPT) can function as rexinoid-X receptor (RXR) agonists.	triphenyltin	53-56	retinoid X receptor alpha	Homo sapiens	95-98
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	42-54	retinoid X receptor alpha	Homo sapiens	178-181
25985376-9	2015	We found that TBT and TPT activated the PPARgamma/RXRalpha C432A heterodimer, which suggests that both compounds can activate the heterodimer through PPARgamma.	triphenyltin	22-25	retinoid X receptor alpha	Homo sapiens	50-58
25985376-9	2015	We found that TBT and TPT activated the PPARgamma/RXRalpha C432A heterodimer, which suggests that both compounds can activate the heterodimer through PPARgamma.	triphenyltin	22-25	peroxisome proliferator activated receptor gamma	Homo sapiens	150-159
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	42-54	peroxisome proliferator activated receptor gamma	Homo sapiens	191-239
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	42-54	peroxisome proliferator activated receptor gamma	Homo sapiens	241-250
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	56-59	retinoid X receptor alpha	Homo sapiens	157-176
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	56-59	retinoid X receptor alpha	Homo sapiens	178-181
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	56-59	peroxisome proliferator activated receptor gamma	Homo sapiens	191-239
25985376-1	2015	Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma).	triphenyltin	56-59	peroxisome proliferator activated receptor gamma	Homo sapiens	241-250
23123459-6	2012	TBT and TPT are dual agonists of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma); they also induce the differentiation of adipocytes in vitro and in vivo, probably through PPARgamma activation, suggesting that they may work as obesogens.	triphenyltin	8-11	retinoid X receptor alpha	Homo sapiens	33-52
25687586-1	2015	Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor gamma (PPARgamma) signaling pathway.	triphenyltin	28-40	limb development membrane protein 1	Homo sapiens	42-45
25687586-1	2015	Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor gamma (PPARgamma) signaling pathway.	triphenyltin	28-40	peroxisome proliferator activated receptor gamma	Homo sapiens	109-157
25687586-1	2015	Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor gamma (PPARgamma) signaling pathway.	triphenyltin	28-40	peroxisome proliferator activated receptor gamma	Homo sapiens	159-168
25462303-0	2015	Modulation of excitatory synaptic transmission in rat hippocampal CA3 neurons by triphenyltin, an environmental pollutant.	triphenyltin	81-93	carbonic anhydrase 3	Rattus norvegicus	66-69
24211812-0	2014	Investigation on the interaction between endocrine disruptor triphenyltin with human serum albumin.	triphenyltin	61-73	albumin	Homo sapiens	85-98
24211812-1	2014	The interaction between triphenyltin (TPT) and human serum albumin (HSA) in physiological buffer (pH=7.4) was investigated by the fluorescence quenching technique.	triphenyltin	24-36	albumin	Homo sapiens	53-66
24211812-1	2014	The interaction between triphenyltin (TPT) and human serum albumin (HSA) in physiological buffer (pH=7.4) was investigated by the fluorescence quenching technique.	triphenyltin	38-41	albumin	Homo sapiens	53-66
23360747-0	2013	Studies on the interaction between triphenyltin and bovine serum albumin by fluorescence and CD spectroscopy.	triphenyltin	35-47	albumin	Homo sapiens	59-72
23360747-1	2013	The interaction between triphenyltin (TPT) and bovine serum albumin (BSA) in physiological buffer (pH=7.4) was investigated by the fluorescence quenching technique.	triphenyltin	24-36	albumin	Homo sapiens	54-67
23360747-1	2013	The interaction between triphenyltin (TPT) and bovine serum albumin (BSA) in physiological buffer (pH=7.4) was investigated by the fluorescence quenching technique.	triphenyltin	38-41	albumin	Homo sapiens	54-67
23123459-6	2012	TBT and TPT are dual agonists of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma); they also induce the differentiation of adipocytes in vitro and in vivo, probably through PPARgamma activation, suggesting that they may work as obesogens.	triphenyltin	8-11	retinoid X receptor alpha	Homo sapiens	54-57
23123459-6	2012	TBT and TPT are dual agonists of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma); they also induce the differentiation of adipocytes in vitro and in vivo, probably through PPARgamma activation, suggesting that they may work as obesogens.	triphenyltin	8-11	peroxisome proliferator activated receptor gamma	Homo sapiens	63-111
23123459-6	2012	TBT and TPT are dual agonists of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma); they also induce the differentiation of adipocytes in vitro and in vivo, probably through PPARgamma activation, suggesting that they may work as obesogens.	triphenyltin	8-11	peroxisome proliferator activated receptor gamma	Homo sapiens	113-122
23123459-6	2012	TBT and TPT are dual agonists of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma); they also induce the differentiation of adipocytes in vitro and in vivo, probably through PPARgamma activation, suggesting that they may work as obesogens.	triphenyltin	8-11	peroxisome proliferator activated receptor gamma	Homo sapiens	215-224
19497422-2	2009	Previously, we reported that TBT and TPT function as powerful agonists for peroxisome proliferator-activated receptor (PPAR) gamma and stimulate adipocyte differentiation via the PPARgamma signaling pathway.	triphenyltin	37-40	peroxisome proliferator activated receptor alpha	Homo sapiens	75-117
20881191-5	2010	Cell-surface CCR9 expression was often induced on a limited population of murine naive CD4(+) T cells by all-trans-RA or the RAR agonist Am80 alone upon CD3/CD28-mediated activation in vitro, but it was markedly enhanced by adding the RXR agonist PA024 or the RXR-binding environmental chemicals tributyltin and triphenyltin.	triphenyltin	312-324	chemokine (C-C motif) receptor 9	Mus musculus	13-17
19497422-7	2009	All tested phenyltin compounds transcriptionally activated GAL-PPARgamma with an order of potency of TPT>DPT>monophenyltin.	triphenyltin	101-104	peroxisome proliferator activated receptor gamma	Homo sapiens	63-72
19497422-2	2009	Previously, we reported that TBT and TPT function as powerful agonists for peroxisome proliferator-activated receptor (PPAR) gamma and stimulate adipocyte differentiation via the PPARgamma signaling pathway.	triphenyltin	37-40	peroxisome proliferator activated receptor alpha	Homo sapiens	119-123
19497422-2	2009	Previously, we reported that TBT and TPT function as powerful agonists for peroxisome proliferator-activated receptor (PPAR) gamma and stimulate adipocyte differentiation via the PPARgamma signaling pathway.	triphenyltin	37-40	peroxisome proliferator activated receptor gamma	Homo sapiens	179-188
19497422-5	2009	TBT, TPT, diphenyltin (DPT), and tetrabutyltin (TeBT) blocked the binding of [(3)H]Rosi to PPARgamma in a competitive manner, and all tested organotin compounds except monobutyltin blocked the binding of [(14)C]TPT to PPARgamma in a competitive manner.	triphenyltin	5-8	peroxisome proliferator activated receptor gamma	Homo sapiens	91-100
16978758-0	2006	In vitro metabolism of tributyltin and triphenyltin by human cytochrome P-450 isoforms.	triphenyltin	39-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	61-77
18670157-8	2008	Recently, organotin compounds including TBT and TPT were identified as nanomolar agonists for retinoid X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) gamma, which are members of the nuclear receptor superfamily.	triphenyltin	48-51	retinoid X receptor alpha	Homo sapiens	94-113
18670157-8	2008	Recently, organotin compounds including TBT and TPT were identified as nanomolar agonists for retinoid X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) gamma, which are members of the nuclear receptor superfamily.	triphenyltin	48-51	retinoid X receptor alpha	Homo sapiens	115-118
18670157-8	2008	Recently, organotin compounds including TBT and TPT were identified as nanomolar agonists for retinoid X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) gamma, which are members of the nuclear receptor superfamily.	triphenyltin	48-51	peroxisome proliferator activated receptor gamma	Homo sapiens	124-179
17291456-7	2007	Our results suggest that TBT and TPT suppress osteoclastogenesis by inhibiting RANKL-induced NFATc1 expression via an RAR-dependent signaling pathway.	triphenyltin	33-36	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	79-84
17291456-7	2007	Our results suggest that TBT and TPT suppress osteoclastogenesis by inhibiting RANKL-induced NFATc1 expression via an RAR-dependent signaling pathway.	triphenyltin	33-36	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	93-99
16978758-2	2006	We used human hepatic cytochrome P-450 (CYP) systems to confirm the specific CYP(s) involved in the in vitro metabolism of tributyltin and triphenyltin.	triphenyltin	139-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-38
16978758-2	2006	We used human hepatic cytochrome P-450 (CYP) systems to confirm the specific CYP(s) involved in the in vitro metabolism of tributyltin and triphenyltin.	triphenyltin	139-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-43
16978758-2	2006	We used human hepatic cytochrome P-450 (CYP) systems to confirm the specific CYP(s) involved in the in vitro metabolism of tributyltin and triphenyltin.	triphenyltin	139-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	77-80
16978758-6	2006	Furthermore, the metabolism of tributyltin and triphenyltin was significantly inhibited in vitro by pretreatment with selective inhibitors, azamulin for CYP3A4 and N-3-benzylnirvanol for CYP2C19.	triphenyltin	47-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	153-159
16978758-6	2006	Furthermore, the metabolism of tributyltin and triphenyltin was significantly inhibited in vitro by pretreatment with selective inhibitors, azamulin for CYP3A4 and N-3-benzylnirvanol for CYP2C19.	triphenyltin	47-59	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	187-194
16978758-7	2006	Since the CYP2C18 content of hepatic microsomes in humans is relatively low, CYP2C9, 2C19, and 3A4 might be the main isoforms of CYP that are responsible for tributyltin and triphenyltin metabolism in the human liver.	triphenyltin	174-186	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	77-83
15019098-0	2004	Identification of principal cytochrome P-450 in triphenyltin metabolism in rats.	triphenyltin	48-60	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	28-44
16788560-8	2006	Recently, it has been demonstrated that TBT and TPT directly bind to the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor (PPAR) gamma with high affinity and function as transcriptional activators.	triphenyltin	48-51	retinoid X receptor alpha	Homo sapiens	73-92
16788560-8	2006	Recently, it has been demonstrated that TBT and TPT directly bind to the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor (PPAR) gamma with high affinity and function as transcriptional activators.	triphenyltin	48-51	retinoid X receptor alpha	Homo sapiens	94-97
16788560-8	2006	Recently, it has been demonstrated that TBT and TPT directly bind to the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor (PPAR) gamma with high affinity and function as transcriptional activators.	triphenyltin	48-51	peroxisome proliferator activated receptor alpha	Homo sapiens	107-149
16788560-8	2006	Recently, it has been demonstrated that TBT and TPT directly bind to the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor (PPAR) gamma with high affinity and function as transcriptional activators.	triphenyltin	48-51	peroxisome proliferator activated receptor alpha	Homo sapiens	151-155
15464999-1	2004	Organotin compounds, triphenyltin (TPT), tributyltin, dibutyltin, and monobutyltin (MBT), showed potent inhibitory effects on both L-arginine oxidation to nitric oxide and L-citrulline, and cytochrome c reduction catalyzed by recombinant rat neuronal nitric oxide synthase (nNOS).	triphenyltin	21-33	nitric oxide synthase 1	Rattus norvegicus	242-272
15464999-1	2004	Organotin compounds, triphenyltin (TPT), tributyltin, dibutyltin, and monobutyltin (MBT), showed potent inhibitory effects on both L-arginine oxidation to nitric oxide and L-citrulline, and cytochrome c reduction catalyzed by recombinant rat neuronal nitric oxide synthase (nNOS).	triphenyltin	21-33	nitric oxide synthase 1	Rattus norvegicus	274-278
15464999-1	2004	Organotin compounds, triphenyltin (TPT), tributyltin, dibutyltin, and monobutyltin (MBT), showed potent inhibitory effects on both L-arginine oxidation to nitric oxide and L-citrulline, and cytochrome c reduction catalyzed by recombinant rat neuronal nitric oxide synthase (nNOS).	triphenyltin	35-38	nitric oxide synthase 1	Rattus norvegicus	242-272
15464999-1	2004	Organotin compounds, triphenyltin (TPT), tributyltin, dibutyltin, and monobutyltin (MBT), showed potent inhibitory effects on both L-arginine oxidation to nitric oxide and L-citrulline, and cytochrome c reduction catalyzed by recombinant rat neuronal nitric oxide synthase (nNOS).	triphenyltin	35-38	nitric oxide synthase 1	Rattus norvegicus	274-278
15205045-6	2004	In vitro studies indicate that TPT can directly activate androgen receptor-mediated transcription and inhibit enzymes that are involved in steroid hormone metabolism.	triphenyltin	31-34	androgen receptor	Homo sapiens	57-74
15256756-4	2004	Carbaryl, alachlor, nonylphenol, octylphenol, tributyltin, and triphenyltin inhibited LPS-induced NO production in vitro, whereas 2,4-dichlorophenoxy acetic acid and bisphenol A enhanced its production.	triphenyltin	63-75	toll-like receptor 4	Mus musculus	86-89
15019098-1	2004	The in vivo and in vitro metabolism of triphenyltin using rat hepatic cytochrome P-450 (CYP) systems was investigated to confirm the specific CYP that is closely related to triphenyltin metabolism.	triphenyltin	39-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	70-86
12767282-7	2003	Co-incubation with DTE (n=3) resulted in dose-response prevention of the inhibitory effects of 100 microM deleterious TPT concentrations on 17beta-HSD 3 (EC(50) value of 12.9 mM; mean of n=3 experiments), 3beta-HSD 2 (0.90 mM; n=3), P450 arom (0.91 mM; n=3) and 17beta-HSD 1 (0.21 mM; n=3) activity.	triphenyltin	118-121	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	140-152
12788061-3	2003	At a low concentration, 10(-7)M, TPT increased superoxide production by differentiated HL-60 cells stimulated with opsonized zymosan (OZ) by about 45% and increased expression of CD18, a component of the OZ-receptor, by about 90%.	triphenyltin	33-36	integrin subunit beta 2	Homo sapiens	179-183
12788061-4	2003	Real-time PCR analysis revealed that TPT augmented the expression not only of CD18 but also of components of superoxide-generating NADPH-oxidase, p47phox, 2.7-fold, and p67phox, 2.0-fold, and of granulocyte colony-stimulating factor receptor (G-CSFR), 3.0-fold, whereas various other endocrine disruptors, including parathion, vinclozolin, and bisphenol A, had no such enhancing effects.	triphenyltin	37-40	integrin subunit beta 2	Homo sapiens	78-82
12788061-4	2003	Real-time PCR analysis revealed that TPT augmented the expression not only of CD18 but also of components of superoxide-generating NADPH-oxidase, p47phox, 2.7-fold, and p67phox, 2.0-fold, and of granulocyte colony-stimulating factor receptor (G-CSFR), 3.0-fold, whereas various other endocrine disruptors, including parathion, vinclozolin, and bisphenol A, had no such enhancing effects.	triphenyltin	37-40	neutrophil cytosolic factor 1	Homo sapiens	146-153
12788061-4	2003	Real-time PCR analysis revealed that TPT augmented the expression not only of CD18 but also of components of superoxide-generating NADPH-oxidase, p47phox, 2.7-fold, and p67phox, 2.0-fold, and of granulocyte colony-stimulating factor receptor (G-CSFR), 3.0-fold, whereas various other endocrine disruptors, including parathion, vinclozolin, and bisphenol A, had no such enhancing effects.	triphenyltin	37-40	neutrophil cytosolic factor 2	Homo sapiens	169-176
12788061-4	2003	Real-time PCR analysis revealed that TPT augmented the expression not only of CD18 but also of components of superoxide-generating NADPH-oxidase, p47phox, 2.7-fold, and p67phox, 2.0-fold, and of granulocyte colony-stimulating factor receptor (G-CSFR), 3.0-fold, whereas various other endocrine disruptors, including parathion, vinclozolin, and bisphenol A, had no such enhancing effects.	triphenyltin	37-40	colony stimulating factor 3 receptor	Homo sapiens	195-241
12788061-4	2003	Real-time PCR analysis revealed that TPT augmented the expression not only of CD18 but also of components of superoxide-generating NADPH-oxidase, p47phox, 2.7-fold, and p67phox, 2.0-fold, and of granulocyte colony-stimulating factor receptor (G-CSFR), 3.0-fold, whereas various other endocrine disruptors, including parathion, vinclozolin, and bisphenol A, had no such enhancing effects.	triphenyltin	37-40	colony stimulating factor 3 receptor	Homo sapiens	243-249
12788061-5	2003	The results of a DNA macroarray analysis showed that TPT enhanced the expression of G-CSFR and certain other neutrophil functional proteins, including CD14 and myeloid leukemia cell differentiation protein (MCL-1), and that TPT induced a decrease in expression of LC-PTP, leukocyte protein-tyrosine phosphatase, to about half the control level.	triphenyltin	53-56	colony stimulating factor 3 receptor	Homo sapiens	84-90
12788061-5	2003	The results of a DNA macroarray analysis showed that TPT enhanced the expression of G-CSFR and certain other neutrophil functional proteins, including CD14 and myeloid leukemia cell differentiation protein (MCL-1), and that TPT induced a decrease in expression of LC-PTP, leukocyte protein-tyrosine phosphatase, to about half the control level.	triphenyltin	53-56	CD14 molecule	Homo sapiens	151-155
12788061-5	2003	The results of a DNA macroarray analysis showed that TPT enhanced the expression of G-CSFR and certain other neutrophil functional proteins, including CD14 and myeloid leukemia cell differentiation protein (MCL-1), and that TPT induced a decrease in expression of LC-PTP, leukocyte protein-tyrosine phosphatase, to about half the control level.	triphenyltin	53-56	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	207-212
12788061-5	2003	The results of a DNA macroarray analysis showed that TPT enhanced the expression of G-CSFR and certain other neutrophil functional proteins, including CD14 and myeloid leukemia cell differentiation protein (MCL-1), and that TPT induced a decrease in expression of LC-PTP, leukocyte protein-tyrosine phosphatase, to about half the control level.	triphenyltin	53-56	protein tyrosine phosphatase non-receptor type 7	Homo sapiens	264-270
15019098-1	2004	The in vivo and in vitro metabolism of triphenyltin using rat hepatic cytochrome P-450 (CYP) systems was investigated to confirm the specific CYP that is closely related to triphenyltin metabolism.	triphenyltin	39-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	88-91
15019098-1	2004	The in vivo and in vitro metabolism of triphenyltin using rat hepatic cytochrome P-450 (CYP) systems was investigated to confirm the specific CYP that is closely related to triphenyltin metabolism.	triphenyltin	39-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	142-145
15019098-1	2004	The in vivo and in vitro metabolism of triphenyltin using rat hepatic cytochrome P-450 (CYP) systems was investigated to confirm the specific CYP that is closely related to triphenyltin metabolism.	triphenyltin	173-185	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	88-91
15019098-1	2004	The in vivo and in vitro metabolism of triphenyltin using rat hepatic cytochrome P-450 (CYP) systems was investigated to confirm the specific CYP that is closely related to triphenyltin metabolism.	triphenyltin	173-185	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	142-145
15019098-2	2004	No significant sex differences occurred between the in vivo and in vitro metabolic patterns of the chemical, indicating that the principal CYP for triphenyltin metabolism in rats is not a sex-specific form of CYP.	triphenyltin	147-159	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	139-142
15019098-5	2004	Furthermore, anti-rat CYP2C6 antibodies and cimetidine, a selective CYP2C6 inhibitor, inhibited triphenyltin dearylation activity in the hepatic microsomes of rats.	triphenyltin	96-108	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	22-28
15019098-5	2004	Furthermore, anti-rat CYP2C6 antibodies and cimetidine, a selective CYP2C6 inhibitor, inhibited triphenyltin dearylation activity in the hepatic microsomes of rats.	triphenyltin	96-108	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	68-74
15019098-6	2004	Taken together, these findings suggest that CYP2C6 is the principal CYP for the triphenyltin metabolism in rats.	triphenyltin	80-92	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	44-50
15019098-6	2004	Taken together, these findings suggest that CYP2C6 is the principal CYP for the triphenyltin metabolism in rats.	triphenyltin	80-92	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	44-47
11097870-4	2000	Stimulation of LA16 cells with 100 nM TBT or 1 nM TPT enhanced both AR-dependent transcription of luciferase gene and cell growth to the same extent as those by 1 nM dihydrotestosterone (DHT).	triphenyltin	50-53	androgen receptor	Homo sapiens	68-70
12050258-6	2002	In all cell lines, both TBT and TPT increased levels of hCG secretion and aromatase activity in a dose- and time-dependent fashion following exposure to nontoxic concentration ranges.	triphenyltin	32-35	hypertrichosis 2 (generalised, congenital)	Homo sapiens	56-59
12046964-1	2002	Triphenyltin (TPT) induces transient hyperglycemia and hypertriglyceridemia in rabbits and hamsters through inhibition of the insulin release stimulated by glucose.	triphenyltin	0-12	insulin	Oryctolagus cuniculus	126-133
12046964-1	2002	Triphenyltin (TPT) induces transient hyperglycemia and hypertriglyceridemia in rabbits and hamsters through inhibition of the insulin release stimulated by glucose.	triphenyltin	14-17	insulin	Oryctolagus cuniculus	126-133
11097870-5	2000	TBT or TPT also enhanced the DNA synthesis and expression of endogenous AR target genes such as prostate specific antigen, but not the expression of AR itself.	triphenyltin	7-10	androgen receptor	Homo sapiens	72-74
11097870-7	2000	On the other hand, simultaneous treatment of LA16 cells with DHT and TBT or TPT caused highly enhanced effects on AR activation.	triphenyltin	76-79	androgen receptor	Homo sapiens	114-116
21781896-2	1998	Triphenyltin at concentrations ranging from 30 nM to 1 muM inhibited the growth of K562 cells in a dose-dependent manner when the cells were incubated with triphenyltin at respective concentrations for 72 h. Triphenyltin at 100 nM slowed the rate of growth without affecting the viability.	triphenyltin	0-12	latexin	Homo sapiens	55-58
11087980-1	2000	The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied.	triphenyltin	210-222	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	15-31
11087980-5	2000	These results suggest that the inhibition of cytochrome P-450 system enzymes by SKF-525A affects the metabolism and toxicity of triphenyltin and has a key role in inducing the hyperglycemic action of triphenyltin, i.e. by increasing triphenyltin accumulation in the mice.	triphenyltin	128-140	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	45-61
11087980-5	2000	These results suggest that the inhibition of cytochrome P-450 system enzymes by SKF-525A affects the metabolism and toxicity of triphenyltin and has a key role in inducing the hyperglycemic action of triphenyltin, i.e. by increasing triphenyltin accumulation in the mice.	triphenyltin	200-212	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	45-61
11087980-5	2000	These results suggest that the inhibition of cytochrome P-450 system enzymes by SKF-525A affects the metabolism and toxicity of triphenyltin and has a key role in inducing the hyperglycemic action of triphenyltin, i.e. by increasing triphenyltin accumulation in the mice.	triphenyltin	200-212	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	45-61
10522495-0	1999	Effects of pretreatment with cytochrome P-450 inducers, especially phenobarbital on triphenyltin metabolism and toxicity in hamsters.	triphenyltin	84-96	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	29-45
10522495-10	1999	These findings suggest that the induction of CYP system enzymes affects the metabolism and toxicity of triphenyltin in hamsters.	triphenyltin	103-115	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-48
21781896-2	1998	Triphenyltin at concentrations ranging from 30 nM to 1 muM inhibited the growth of K562 cells in a dose-dependent manner when the cells were incubated with triphenyltin at respective concentrations for 72 h. Triphenyltin at 100 nM slowed the rate of growth without affecting the viability.	triphenyltin	156-168	latexin	Homo sapiens	55-58
21781896-2	1998	Triphenyltin at concentrations ranging from 30 nM to 1 muM inhibited the growth of K562 cells in a dose-dependent manner when the cells were incubated with triphenyltin at respective concentrations for 72 h. Triphenyltin at 100 nM slowed the rate of growth without affecting the viability.	triphenyltin	208-220	latexin	Homo sapiens	55-58
7867695-6	1994	Removing Ca2+ from external solution and prolonged treatment with either caffeine (20 mM) or ryanodine (2 microM) inhibited the triphenyltin-induced contracture.	triphenyltin	128-140	carbonic anhydrase 2	Mus musculus	9-12
7867695-8	1994	45Ca2+ uptake studies showed that triphenyltin caused the muscle to accumulate Ca2+ which entered from external solution.	triphenyltin	34-46	carbonic anhydrase 2	Mus musculus	2-5
1457596-5	1992	Proton transport was inhibited by the ATPase blockers DCCD, triphenyltin, and venturicidin.	triphenyltin	60-72	ATPase	Escherichia coli	38-44
2280903-3	1990	TPT at concentrations of 10(-7) to 10(-5) M increased the peak amplitude of INa associated with a prolongation of current decay.	triphenyltin	0-3	internexin neuronal intermediate filament protein alpha	Homo sapiens	76-79
34450426-6	2021	However, dietary quercetin prevented a marked increase in the Bax, caspase3 and caspase9 transcript abundances that were induced by TPT.	triphenyltin	132-135	caspase 9, apoptosis-related cysteine peptidase	Danio rerio	80-88
34450426-6	2021	However, dietary quercetin prevented a marked increase in the Bax, caspase3 and caspase9 transcript abundances that were induced by TPT.	triphenyltin	132-135	BCL2 associated X, apoptosis regulator a	Danio rerio	62-65
34450426-6	2021	However, dietary quercetin prevented a marked increase in the Bax, caspase3 and caspase9 transcript abundances that were induced by TPT.	triphenyltin	132-135	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	67-75
35489455-5	2022	TPT at 2 mg/kg significantly decreased the gene and protein expressions of testis PCNA and Ki67, and dose-dependently decreased the number of PCNA-positive cells and Ki67-positive cells.	triphenyltin	0-3	proliferating cell nuclear antigen	Rattus norvegicus	82-86
35489455-5	2022	TPT at 2 mg/kg significantly decreased the gene and protein expressions of testis PCNA and Ki67, and dose-dependently decreased the number of PCNA-positive cells and Ki67-positive cells.	triphenyltin	0-3	antigen identified by monoclonal antibody Ki 67	Mus musculus	91-95
35489455-5	2022	TPT at 2 mg/kg significantly decreased the gene and protein expressions of testis PCNA and Ki67, and dose-dependently decreased the number of PCNA-positive cells and Ki67-positive cells.	triphenyltin	0-3	proliferating cell nuclear antigen	Rattus norvegicus	142-146
35489455-5	2022	TPT at 2 mg/kg significantly decreased the gene and protein expressions of testis PCNA and Ki67, and dose-dependently decreased the number of PCNA-positive cells and Ki67-positive cells.	triphenyltin	0-3	antigen identified by monoclonal antibody Ki 67	Mus musculus	166-170
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	steroidogenic acute regulatory protein	Mus musculus	63-67
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	splicing factor 1	Mus musculus	69-72
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	74-81
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	follicle stimulating hormone receptor	Mus musculus	83-87
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	WT1 transcription factor	Mus musculus	89-92
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	DEAD box helicase 4	Mus musculus	94-98
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	zinc finger and BTB domain containing 16	Mus musculus	103-107
35489455-6	2022	TPT at 1 mg/kg and/or 2 mg/kg down-regulated the expression of StAR, SF1, P450scc, FSHR, WT1, DDX4 and PLZF, and up-regulated SOX9 expression.	triphenyltin	0-3	SRY (sex determining region Y)-box 9	Mus musculus	126-130
35489455-7	2022	Simultaneously, TPT reduced serum testosterone levels at each dose and dose-dependently decreased the expression of Leydig cells regulators (INSL3, IGF1, inhibin B) and Sertoli cells regulators (GDNF, FGF2, CXCL12, ETV5), altered testicular microenvironment.	triphenyltin	16-19	insulin-like 3	Mus musculus	141-146
35489455-7	2022	Simultaneously, TPT reduced serum testosterone levels at each dose and dose-dependently decreased the expression of Leydig cells regulators (INSL3, IGF1, inhibin B) and Sertoli cells regulators (GDNF, FGF2, CXCL12, ETV5), altered testicular microenvironment.	triphenyltin	16-19	insulin-like growth factor 1	Mus musculus	148-152
35489455-7	2022	Simultaneously, TPT reduced serum testosterone levels at each dose and dose-dependently decreased the expression of Leydig cells regulators (INSL3, IGF1, inhibin B) and Sertoli cells regulators (GDNF, FGF2, CXCL12, ETV5), altered testicular microenvironment.	triphenyltin	16-19	glial cell line derived neurotrophic factor	Mus musculus	195-199
35489455-7	2022	Simultaneously, TPT reduced serum testosterone levels at each dose and dose-dependently decreased the expression of Leydig cells regulators (INSL3, IGF1, inhibin B) and Sertoli cells regulators (GDNF, FGF2, CXCL12, ETV5), altered testicular microenvironment.	triphenyltin	16-19	fibroblast growth factor 2	Mus musculus	201-205
35489455-7	2022	Simultaneously, TPT reduced serum testosterone levels at each dose and dose-dependently decreased the expression of Leydig cells regulators (INSL3, IGF1, inhibin B) and Sertoli cells regulators (GDNF, FGF2, CXCL12, ETV5), altered testicular microenvironment.	triphenyltin	16-19	chemokine (C-X-C motif) ligand 12	Mus musculus	207-213
35489455-7	2022	Simultaneously, TPT reduced serum testosterone levels at each dose and dose-dependently decreased the expression of Leydig cells regulators (INSL3, IGF1, inhibin B) and Sertoli cells regulators (GDNF, FGF2, CXCL12, ETV5), altered testicular microenvironment.	triphenyltin	16-19	ets variant 5	Mus musculus	215-219
35489455-9	2022	However, after co-culturing TPT-treated TM3 or TM4 cells with GC-1 cells, it was found that TPT-treated TM3 or TM4 cells dose-dependently reduced the gene and protein expression levels of PCNA and Ki67 and increased cytotoxicity in GC-1 cells.	triphenyltin	28-31	proliferating cell nuclear antigen	Mus musculus	188-192
35489455-9	2022	However, after co-culturing TPT-treated TM3 or TM4 cells with GC-1 cells, it was found that TPT-treated TM3 or TM4 cells dose-dependently reduced the gene and protein expression levels of PCNA and Ki67 and increased cytotoxicity in GC-1 cells.	triphenyltin	28-31	antigen identified by monoclonal antibody Ki 67	Mus musculus	197-201
35489455-9	2022	However, after co-culturing TPT-treated TM3 or TM4 cells with GC-1 cells, it was found that TPT-treated TM3 or TM4 cells dose-dependently reduced the gene and protein expression levels of PCNA and Ki67 and increased cytotoxicity in GC-1 cells.	triphenyltin	92-95	proliferating cell nuclear antigen	Mus musculus	188-192
35489455-9	2022	However, after co-culturing TPT-treated TM3 or TM4 cells with GC-1 cells, it was found that TPT-treated TM3 or TM4 cells dose-dependently reduced the gene and protein expression levels of PCNA and Ki67 and increased cytotoxicity in GC-1 cells.	triphenyltin	92-95	antigen identified by monoclonal antibody Ki 67	Mus musculus	197-201
3468922-5	1986	TPT has been shown to be an effective inhibitor of rat liver glutathione-S-transferase activity.	triphenyltin	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	61-86
33513483-4	2021	The results showed that 10 ng/L TPT induced oxidative stress and significantly decreased the activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), in the liver and the gene expression of SOD, GPx, metallothionein (MT), and peroxiredoxin-4 (Prdx-4).	triphenyltin	32-35	metallothionein	Carassius auratus	263-278
33513483-4	2021	The results showed that 10 ng/L TPT induced oxidative stress and significantly decreased the activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), in the liver and the gene expression of SOD, GPx, metallothionein (MT), and peroxiredoxin-4 (Prdx-4).	triphenyltin	32-35	metallothionein	Carassius auratus	280-282
33513483-5	2021	The concentration of malondialdehyde (MDA) and the gene expression of cytochrome P450 (CYP) and glutathione S-transferase (GST) in the liver were significantly increased in the TPT-treated group.	triphenyltin	177-180	glutathione S-transferase 3-like	Carassius auratus	96-121
33513483-5	2021	The concentration of malondialdehyde (MDA) and the gene expression of cytochrome P450 (CYP) and glutathione S-transferase (GST) in the liver were significantly increased in the TPT-treated group.	triphenyltin	177-180	glutathione S-transferase 3-like	Carassius auratus	123-126
33549631-0	2021	Potent Inhibition of Tributyltin (TBT) and Triphenyltin (TPT) against multiple UDP-glucurpnosyltranseferases (UGT): a new potential mechanism underlying endocrine disrupting actions.	triphenyltin	43-55	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	79-108
33549631-0	2021	Potent Inhibition of Tributyltin (TBT) and Triphenyltin (TPT) against multiple UDP-glucurpnosyltranseferases (UGT): a new potential mechanism underlying endocrine disrupting actions.	triphenyltin	43-55	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	110-113
33549631-0	2021	Potent Inhibition of Tributyltin (TBT) and Triphenyltin (TPT) against multiple UDP-glucurpnosyltranseferases (UGT): a new potential mechanism underlying endocrine disrupting actions.	triphenyltin	57-60	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	79-108
33549631-0	2021	Potent Inhibition of Tributyltin (TBT) and Triphenyltin (TPT) against multiple UDP-glucurpnosyltranseferases (UGT): a new potential mechanism underlying endocrine disrupting actions.	triphenyltin	57-60	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	110-113
33549631-6	2021	UGT1A1 and -1A10 were inhibited by TPT, whereas UGT 2B4 and -2B7 were inhibited by TBT.	triphenyltin	35-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-16
33549631-7	2021	Kinetic analyses further indicated that TBT and TPT are two competitive nanomolar inhibitors of UGT2B15, with Ki values of 0.45 and 0.46 muM, respectively.	triphenyltin	48-51	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	96-103
33549631-10	2021	TPT can additionally inhibit activities of UGT1A1 and -1A10 in estradiol-3-O-glucuronidation, with IC50 values of a few micro-molars.	triphenyltin	0-3	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-59
32504733-8	2020	RNA-seq and qPCR showed that triphenyltin dose-dependently down-regulated the expression of the genes for cholesterol transport and biosynthesis, including Scarb1, Ldlr, Hmgcs1, Hmgcr, and Hsd17b7.	triphenyltin	29-41	scavenger receptor class B, member 1	Rattus norvegicus	156-162
32504733-8	2020	RNA-seq and qPCR showed that triphenyltin dose-dependently down-regulated the expression of the genes for cholesterol transport and biosynthesis, including Scarb1, Ldlr, Hmgcs1, Hmgcr, and Hsd17b7.	triphenyltin	29-41	low density lipoprotein receptor	Rattus norvegicus	164-168
32504733-8	2020	RNA-seq and qPCR showed that triphenyltin dose-dependently down-regulated the expression of the genes for cholesterol transport and biosynthesis, including Scarb1, Ldlr, Hmgcs1, Hmgcr, and Hsd17b7.	triphenyltin	29-41	3-hydroxy-3-methylglutaryl-CoA synthase 1	Rattus norvegicus	170-176
32504733-8	2020	RNA-seq and qPCR showed that triphenyltin dose-dependently down-regulated the expression of the genes for cholesterol transport and biosynthesis, including Scarb1, Ldlr, Hmgcs1, Hmgcr, and Hsd17b7.	triphenyltin	29-41	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	178-183
32504733-8	2020	RNA-seq and qPCR showed that triphenyltin dose-dependently down-regulated the expression of the genes for cholesterol transport and biosynthesis, including Scarb1, Ldlr, Hmgcs1, Hmgcr, and Hsd17b7.	triphenyltin	29-41	hydroxysteroid (17-beta) dehydrogenase 7	Rattus norvegicus	189-196