PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2514241-6 1989 The conclusion that this enzyme initiates the formation of GABA by this pathway is indicated by the observation that adrenal slices pretreated with the DAO inhibitor, aminoguanidine, released significantly less [1,4-14C]putrescine-derived GABA in response to 48 mmol K+/l than did control tissues. pimagedine 167-181 amine oxidase, copper containing 1 Rattus norvegicus 152-155 3143132-2 1988 Treatment with aminoguanidine, a potent inhibitor of diamine oxidase (EC 1.4.3.6), was performed during pregnancy, before histamine levels were spontaneously increased. pimagedine 15-29 amine oxidase, copper containing 1 Rattus norvegicus 53-68 2498301-0 1989 Kinetic studies on the inhibition mechanism of diamine oxidase from porcine kidney by aminoguanidine. pimagedine 86-100 amine oxidase copper containing 1 Homo sapiens 47-62 2498301-1 1989 The mechanism of inhibition of diamine oxidase [DAO, histaminase, amine: oxygen oxidoreductase (deaminating) (copper-containing), EC 1.4.3.6] by aminoguanidine was studied kinetically. pimagedine 145-159 amine oxidase copper containing 1 Homo sapiens 31-46 2498301-1 1989 The mechanism of inhibition of diamine oxidase [DAO, histaminase, amine: oxygen oxidoreductase (deaminating) (copper-containing), EC 1.4.3.6] by aminoguanidine was studied kinetically. pimagedine 145-159 D-amino acid oxidase Homo sapiens 48-51 2498301-1 1989 The mechanism of inhibition of diamine oxidase [DAO, histaminase, amine: oxygen oxidoreductase (deaminating) (copper-containing), EC 1.4.3.6] by aminoguanidine was studied kinetically. pimagedine 145-159 amine oxidase copper containing 1 Homo sapiens 53-64 3166996-9 1988 The cross-linking reaction was inhibited when the reaction of RNase A with glyceraldehyde was carried out in the presence of amino compounds, such as glycine ethyl ester, ethanolamine, glucosamine, and aminoguanidine. pimagedine 202-216 ribonuclease A family member 1, pancreatic Homo sapiens 62-69 3143366-9 1988 So far several compounds, including levamisole, imidazole, theophylline and aminoguanidine are known to possess immunomodulating activities in vivo and/or in vitro and inhibit ALP and/or DAO. pimagedine 76-90 alkaline phosphatase, placental Homo sapiens 176-179 3143366-9 1988 So far several compounds, including levamisole, imidazole, theophylline and aminoguanidine are known to possess immunomodulating activities in vivo and/or in vitro and inhibit ALP and/or DAO. pimagedine 76-90 amine oxidase copper containing 1 Homo sapiens 187-190 3111195-3 1987 The diamine oxidase inhibitor aminoguanidine was administered to rats in a single dose of 100 mg/kg orally, i.v., or i.p. pimagedine 30-44 amine oxidase, copper containing 1 Rattus norvegicus 4-19 3135801-3 1988 Aminoguanidine, a diamine oxidase inhibitor, decreases the GABA concentration in the adrenal gland by more than 70% after 4 h, and almost to zero in 24 h. Studies using [14C]putrescine confirm that [14C]GABA is the major metabolite of putrescine in the adrenal gland. pimagedine 0-14 amine oxidase, copper containing 1 Rattus norvegicus 18-33 3106317-3 1987 This effect could be reversed by aminoguanidine reacting with diamine oxidase (DAO), which is present in FBS but not in HS. pimagedine 33-47 amine oxidase copper containing 1 Homo sapiens 62-77 3111195-0 1987 Elevation of the large bowel histamine concentration by aminoguanidine induced diamine oxidase inhibition. pimagedine 56-70 amine oxidase copper containing 1 Homo sapiens 79-94 3106317-3 1987 This effect could be reversed by aminoguanidine reacting with diamine oxidase (DAO), which is present in FBS but not in HS. pimagedine 33-47 amine oxidase copper containing 1 Homo sapiens 79-82 3087998-2 1986 Aminoguanidine, a potent inhibitor of diamine oxidase, blocked the metabolic conversion of polyamines to amino acids but had no effect on the metabolic labeling of the 18,000-dalton protein. pimagedine 0-14 amine oxidase copper containing 1 Homo sapiens 38-53 3104373-8 1986 The 15NH3 production was time dependent and strongly inhibited by the addition of aminoguanidine, an inhibitor of diamine oxidase. pimagedine 82-96 amine oxidase copper containing 1 Homo sapiens 114-129 6428190-5 1984 Semicarbazide and aminoguanidine are 10-respectively 1000-fold more potent inhibitors of the human intestinal diamine oxidase. pimagedine 18-32 amine oxidase copper containing 1 Homo sapiens 110-125 3021663-3 1986 In animals pretreated with aminoguanidine, an inhibitor of diamine oxidase, the enzyme important in the metabolism of putrescine, defluorination was markedly reduced, but uptake by the prostate did not improve. pimagedine 27-41 amine oxidase, copper containing 1 Rattus norvegicus 59-74 6411077-3 1983 Experiments carried out with the combination of difluoromethylornithine and aminoguanidine, a potent inhibitor of diamine oxidase (EC 1.4.3.6), indicated that the methylglyoxal bis(guanylhydrazone)-induced reversal of polyamine depletion was mediated by the known inhibition of diamine oxidase by the diguanidine. pimagedine 76-90 amine oxidase, copper-containing 1 Mus musculus 114-129 6417393-9 1983 In both glomeruli and tubules, the diamine oxidase inhibitor, amino-guanidine, abolished the production of acid metabolites while amodiaquine and pyrilamine, inhibitors of the methylation pathway, markedly reduced the production of N tau-methylhistamine. pimagedine 62-77 amine oxidase, copper containing 1 Rattus norvegicus 35-50 6411077-3 1983 Experiments carried out with the combination of difluoromethylornithine and aminoguanidine, a potent inhibitor of diamine oxidase (EC 1.4.3.6), indicated that the methylglyoxal bis(guanylhydrazone)-induced reversal of polyamine depletion was mediated by the known inhibition of diamine oxidase by the diguanidine. pimagedine 76-90 amine oxidase, copper-containing 1 Mus musculus 278-293 6403048-8 1983 Aminoguanidine strongly inhibited human intestinal diamine oxidase (IC50 = 1.1 x 10(-8) M). pimagedine 0-14 amine oxidase copper containing 1 Homo sapiens 51-66 6830862-8 1983 Aminoguanidine, a potent inhibitor of diamine oxidase, completely inhibited the fetal calf serum-stimulated labeling of these cellular proteins but had no effect on the labeling of the 18-kDa protein. pimagedine 0-14 amine oxidase copper containing 1 Homo sapiens 38-53 6218830-6 1983 The administration of aminoguanidine to isoproterenol-treated rats caused in the heart an inhibition of diamine oxidase activity that led to an increase in putrescine level beyond the values found in animals given isoproterenol alone. pimagedine 22-36 amine oxidase, copper containing 1 Rattus norvegicus 104-119 6831037-8 1983 It could be partially eliminated by aminoguanidine, which neutralizes diamine oxidase present in fetal calf serum used in the CFU-C assay. pimagedine 36-50 amine oxidase, copper-containing 1 Mus musculus 70-85 6884567-9 1983 Treatment of rats with aminoguanidine sulfate, an inhibitor of diamine oxidase, causes a decrease in the excretion of N-(3-aminopropyl)pyrrolidin-2-one and its derivatives. pimagedine 23-45 amine oxidase, copper containing 1 Rattus norvegicus 63-78 6884567-11 1983 Its formation is catalyzed by an aminoguanidine sensitive, diamine oxidase-like enzyme. pimagedine 33-47 amine oxidase, copper containing 1 Rattus norvegicus 59-74 7075355-4 1982 The diamine oxidase inhibitor aminoguanidine also protected. pimagedine 30-44 amine oxidase copper containing 1 Homo sapiens 4-19 6803541-2 1981 In mice pretreated with aminoguanidine, a powerful inhibitor of diamine oxidase, and then with 14C-putrescine, tissue levels of the radioactive catabolites, gamma-aminobutyric acid and the unidentified compound were markedly reduced. pimagedine 24-38 amine oxidase, copper-containing 1 Mus musculus 64-79 6794904-3 1981 This inhibition was partially reversed by the diamine oxidase inhibitor aminoguanidine. pimagedine 72-86 amine oxidase, copper containing 1 Rattus norvegicus 46-61 6814191-5 1981 After treatment of pregnant rats with the diamine oxidase inhibitor aminoguanidine the expiration of 14CO2 was almost completely inhibited. pimagedine 68-82 amine oxidase, copper containing 1 Rattus norvegicus 42-57 6459827-5 1981 These observations probably show a reduction of the activity of the diamine oxidase under the influence of amino-guanidine sulfate. pimagedine 107-130 amine oxidase, copper containing 1 Rattus norvegicus 68-83 6215274-5 1982 To reveal full inhibitory potency, methylhydrazine and aminoguanidine need longer preincubation with plant diamine oxidase as compared with mammalian diamine oxidase. pimagedine 55-69 amine oxidase copper containing 1 Homo sapiens 107-122 7435118-5 1980 Treatment with aminoguanidine elevated the content of cadaverine in the ovary, suggesting that diamine oxidase has a role as a regulator of the intra-ovary level of cadaverine. pimagedine 15-29 amine oxidase copper containing 1 Homo sapiens 95-110 6771147-1 1980 Rats treated acutely with aminoguanidine, a potent inhibitor of diamine oxidase, or with heparin display reduced ability to metabolize 14C-putrescine to radioactive carbon dioxide. pimagedine 26-40 amine oxidase, copper containing 1 Rattus norvegicus 64-79 6789795-3 1980 putrescine infection, its main oxidative metabolites, namely GABA and an unidentified compound were detected in all tissues tested; inhibition of DAO activity by aminoguanidine strongly suppressed formation of both products. pimagedine 162-176 D-amino acid oxidase Mus musculus 146-149 6770612-4 1980 Aminoguanidine and semicarbazide inhibited the human intestinal enzyme like a classical diamine oxidase. pimagedine 0-14 amine oxidase copper containing 1 Homo sapiens 88-103 161853-2 1979 When administered in combination with the diamine oxidase inhibitor, aminoguanidine, an almost complete block of histamine metabolism was observed. pimagedine 69-83 amine oxidase, copper-containing 1 Mus musculus 42-57 110032-5 1979 Treatment with aminoguanidine generally elevated the content of cadaverine, indicating a role of diamine oxidase as a regulator of diamine content. pimagedine 15-29 amine oxidase, copper containing 1 Rattus norvegicus 97-112 745086-11 1978 Under the influence of the diamine oxidase inhibitor aminoguanidine the general pattern of excretion of diamines and polyamines in pregnant rats remained essentially unchanged but the total amount excreted increased. pimagedine 53-67 amine oxidase, copper containing 1 Rattus norvegicus 27-42 686917-2 1978 Urinary methylhistamine excretion is approximately trebled in rats treated simultaneously with the histaminase inhibitor aminoguanidine and the monoamine oxidase inhibitor pargyline, thus providing a high base-line against which inhibiton of methylhistamine formation, and hence of histamine formation, can be measured. pimagedine 121-135 amine oxidase, copper containing 1 Rattus norvegicus 99-110 99252-1 1978 The inhibitory effect of the polyamines, spermidine and spermine, on the proliferation of human fibroblasts in culture was found to be reversed by the addition of aminoguanidine (AM), a specific and highly effective inhibitor of diamine oxidase (DAO) present in fetal calf serum (FCS). pimagedine 163-177 amine oxidase copper containing 1 Homo sapiens 229-244 99252-1 1978 The inhibitory effect of the polyamines, spermidine and spermine, on the proliferation of human fibroblasts in culture was found to be reversed by the addition of aminoguanidine (AM), a specific and highly effective inhibitor of diamine oxidase (DAO) present in fetal calf serum (FCS). pimagedine 163-177 amine oxidase copper containing 1 Homo sapiens 246-249 98970-2 1978 However, augmentation of gastric acid secretion by aminoguanidine, the strong inhibitor of diamine oxidase, indicated an influence of diamine oxidase activity on this secretory process. pimagedine 51-65 amine oxidase copper containing 1 Homo sapiens 91-106 98970-2 1978 However, augmentation of gastric acid secretion by aminoguanidine, the strong inhibitor of diamine oxidase, indicated an influence of diamine oxidase activity on this secretory process. pimagedine 51-65 amine oxidase copper containing 1 Homo sapiens 134-149 1015492-6 1976 The histaminase inhibitor aminoguanidine strongly aggravated the histamine-induced gastric lesions in pregnant rats as compared with the non-pregnant ones. pimagedine 26-40 amine oxidase, copper containing 1 Rattus norvegicus 4-15 646807-5 1978 This return correlated with the rapid loss of the diamines from the liver, and the decrease in activity could be slightly prolonged by treatment with aminoguanidine, a diamine oxidase inhibitor. pimagedine 150-164 amine oxidase, copper containing 1 Rattus norvegicus 168-183 857596-2 1977 In addition, histamine metabolism was studied in five healthy women at delivery and in four other healthy pregnant women during treatment with aminoguanidine, which is an inhibitor of diamino oxidase (histaminase). pimagedine 143-157 amine oxidase copper containing 1 Homo sapiens 201-212 827404-2 1976 The loss of histamine activity was due to enzymic degradation of histamine by diamine oxidase since it was reversed by aminoguanidine. pimagedine 119-133 amiloride-sensitive amine oxidase [copper-containing] Cavia porcellus 78-93 1269-8 1975 By applying a new theory for time-dependent inhibition, the inhibition of diamine oxidase by aminoguanidine and phenylhydrazine is adequately accounted for. pimagedine 93-107 amine oxidase copper containing 1 Homo sapiens 74-89 977943-8 1976 Increasing the concentration of pyridoxal phosphate, the HDC coenzyme, above that normally present in culture medium resulted in only an equivocal increase in the amount of newly synthesized histamine, whereas aminoguanidine, an inhibitor of histaminase, had no detectable effect. pimagedine 210-224 histidine decarboxylase Cavia porcellus 57-60 63382-7 1975 Aminoguanidine, a diamine oxidase inhibitor, had no effect on catabolism. pimagedine 0-14 amine oxidase, copper containing 1 Rattus norvegicus 18-33 50437-4 1975 Inhibitory effects were also observed with the histamine releaser, sinomenine, and the histaminase inhibitor, aminoguanidine. pimagedine 110-124 amine oxidase, copper containing 1 Rattus norvegicus 87-98 1239911-3 1975 The urinary excretion of histamine and methylhistamine reflects fairly well the total histamine turnover in the animal, provided that aminoguanidine is administered to inhibit diamine oxidase activity. pimagedine 134-148 amiloride-sensitive amine oxidase [copper-containing] Cavia porcellus 176-191 5158213-0 1971 Inhibition of histidine decarboxylase in rat stomach by aminoguanidine. pimagedine 56-70 histidine decarboxylase Rattus norvegicus 14-37 5547758-2 1971 On the other hand, aminoguanidine (an inhibitor of histaminase) has no effect on acid secretion or ulceration in these animals. pimagedine 19-33 amine oxidase, copper containing 1 Rattus norvegicus 51-62 4985984-3 1970 Pretreatment of mice with aminoguanidine, an inhibitor of diamine oxidase, strongly increased levels of (14)C-histamine in intestine; pretreatment with aminoguanidine plus a monoamine oxidase inhibitor strongly increased levels of (14)C-methylhistamine in liver. pimagedine 26-40 amine oxidase, copper-containing 1 Mus musculus 58-73 4985984-3 1970 Pretreatment of mice with aminoguanidine, an inhibitor of diamine oxidase, strongly increased levels of (14)C-histamine in intestine; pretreatment with aminoguanidine plus a monoamine oxidase inhibitor strongly increased levels of (14)C-methylhistamine in liver. pimagedine 152-166 amine oxidase, copper-containing 1 Mus musculus 58-73 14256808-5 1964 Iproniazid and aminoguanidine potentiated responses to gastrin. pimagedine 15-29 gastrin Rattus norvegicus 55-62 13869633-1 1961 Treatment with thyroxine or liothyronine increased the urinary excretion of free histamine in male and female rats under the influence of aminoguanidine, a histaminase inhibitor. pimagedine 138-152 amine oxidase, copper containing 1 Rattus norvegicus 156-167 13362513-0 1956 Effect of an histaminase inhibitor (aminoguanidine) on the gastric secretory response to exogenous histamine. pimagedine 36-50 amine oxidase copper containing 1 Homo sapiens 13-24 4879882-13 1968 The activity of caerulein is sharply reduced by pretreatment of the rats with the histamine liberator 48/80 and potentiated by pretreatment with the diamine oxidase inhibitor aminoguanidine. pimagedine 175-189 amine oxidase, copper containing 1 Rattus norvegicus 149-164 13767230-4 1961 The low level of free histamine excretion by male rats was not increased by compound SKF 525-A, and inhibition of diamine oxidase by aminoguanidine caused the same proportionate increase in both sexes. pimagedine 133-147 amine oxidase, copper containing 1 Rattus norvegicus 114-129 32950497-8 2020 In addition, co-administration of L-NAME (a non-specific NO synthase inhibitor) and aminoguanidine (an inducible NO synthase inhibitor) with modafinil significantly neutralized the gastroprotective effect of modafinil in the indomethacin and water-immersion stress groups (P < 0.05, and P < 0.01; respectively), while 7-nitroindazole (a neuronal NO synthase inhibitor) did not show such reversing effects. pimagedine 84-98 nitric oxide synthase 2 Rattus norvegicus 103-124 30691306-3 2021 The aim of the present study was to explore the protective effects of aminoguanidine (AG) as inducible nitric oxide synthase (iNOS) inhibitor against LPS -induced liver dysfunction in rat. pimagedine 70-84 nitric oxide synthase 2 Rattus norvegicus 93-124 30691306-3 2021 The aim of the present study was to explore the protective effects of aminoguanidine (AG) as inducible nitric oxide synthase (iNOS) inhibitor against LPS -induced liver dysfunction in rat. pimagedine 70-84 nitric oxide synthase 2 Rattus norvegicus 126-130 33949165-0 2021 Aminoguanidine ameliorates ovariectomy-induced neuronal deficits in rats by inhibiting AGE-mediated Abeta production. pimagedine 0-14 renin binding protein Rattus norvegicus 87-90 33949165-0 2021 Aminoguanidine ameliorates ovariectomy-induced neuronal deficits in rats by inhibiting AGE-mediated Abeta production. pimagedine 0-14 amyloid beta precursor protein Rattus norvegicus 100-105 33949165-2 2021 There is much evidence describing the beneficial effects of aminoguanidine (AG) on the central nervous system; AG is able to inhibit the receptor for AGEs and beta-amyloid (Abeta) deposition in the brain, thus preventing cognitive decline and neurodegeneration. pimagedine 60-74 amyloid beta precursor protein Rattus norvegicus 173-178 33949165-13 2021 There is much evidence describing the beneficial effects of aminoguanidine (AG) on the central nervous system; AG is able to inhibit the receptor for AGEs and beta-amyloid (Abeta) deposition in the brain, thus preventing cognitive decline and neurodegeneration. pimagedine 60-74 amyloid beta precursor protein Rattus norvegicus 173-178 33091562-8 2020 Estrogen or aminoguanidine (iNOS inhibitor), but not pentoxifylline (TNFalpha inhibitor), abolished LPS/nicotine hypotension. pimagedine 12-26 nitric oxide synthase 2 Rattus norvegicus 28-32 33170977-6 2020 The NOS inhibitors 7-NI and aminoguanidine (AMG) decreased the number of escape failures in LH, and counteracted the changes in hippocampal DNMT3b mRNA induced in this behavioral paradigm. pimagedine 28-42 DNA methyltransferase 3 beta Rattus norvegicus 140-146 33170977-6 2020 The NOS inhibitors 7-NI and aminoguanidine (AMG) decreased the number of escape failures in LH, and counteracted the changes in hippocampal DNMT3b mRNA induced in this behavioral paradigm. pimagedine 44-47 DNA methyltransferase 3 beta Rattus norvegicus 140-146 32755816-7 2020 The anticonvulsant effect of morphine was inhibited completely by the concomitant administration of NO synthase (NOS) inhibitors including nonspecific NOS inhibitor (L-NAME, 10 mg/kg), inducible NOS inhibitor (aminoguanidine, 50 mg/kg), and neuronal NOS inhibitor (7-nitroindazole (7-NI), 15 mg/kg) for five consecutive days. pimagedine 210-224 nitric oxide synthase 1, neuronal Mus musculus 100-111 33091049-0 2020 Inducible nitric oxide synthase blockade with aminoguanidine, protects mice infected with Nocardia brasiliensis from actinomycetoma development. pimagedine 46-60 nitric oxide synthase 2, inducible Mus musculus 0-31 32911032-11 2020 However, aminoguanidine restricted these proteins changes by inhibiting the interaction of AGEs and RAGE. pimagedine 9-23 advanced glycosylation end product-specific receptor Mus musculus 100-104 33091049-11 2020 Aminoguanidine is a competitive inhibitor of inducible nitric oxide synthase. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 45-76 32479691-0 2020 Inducible nitric oxide synthase inhibitor, aminoguanidine improved Ki67 as a marker of neurogenesis and learning and memory in juvenile hypothyroid rats. pimagedine 43-57 nitric oxide synthase 2 Rattus norvegicus 0-31 32765755-0 2020 Aminoguanidine inhibits IL-1beta-induced protein expression of iNOS and COX-2 by blocking the NF-kappaB signaling pathway in rat articular chondrocytes. pimagedine 0-14 interleukin 1 alpha Rattus norvegicus 24-32 32765755-0 2020 Aminoguanidine inhibits IL-1beta-induced protein expression of iNOS and COX-2 by blocking the NF-kappaB signaling pathway in rat articular chondrocytes. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 63-67 32765755-0 2020 Aminoguanidine inhibits IL-1beta-induced protein expression of iNOS and COX-2 by blocking the NF-kappaB signaling pathway in rat articular chondrocytes. pimagedine 0-14 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 72-77 32765755-2 2020 As an inhibitor of inducible nitric oxide synthase (iNOS), aminoguanidine (AG) displays anti-inflammatory effects. pimagedine 59-73 nitric oxide synthase 2 Rattus norvegicus 19-50 32765755-2 2020 As an inhibitor of inducible nitric oxide synthase (iNOS), aminoguanidine (AG) displays anti-inflammatory effects. pimagedine 59-73 nitric oxide synthase 2 Homo sapiens 52-56 32819437-4 2020 The impact of iNOS inhibition by aminoguanidine on parasite burden and growth was then evaluated in vivo. pimagedine 33-47 nitric oxide synthase 2, inducible Mus musculus 14-18 32302594-10 2020 This effect was iNOS-dependent because pretreatment of a low dose of aminoguanidine (20 mg/kg) 15 min before the administration of a low dose of cyclosporine (1 mg/kg) reversed the proconvulsant action of sildenafil (40 mg/kg). pimagedine 69-83 nitric oxide synthase 2, inducible Mus musculus 16-20 32011309-1 2019 The aim of the research was to study the content of myelin basic protein (MBP) in the cerebellum and cerebral hemispheres of the BALB/c mice with experimental antiphospholipid syndrome as well as in cases of introduction of L-arginine and aminoguanidine. pimagedine 239-253 myelin basic protein Mus musculus 52-72 32256730-0 2020 Triamcinolone acetonide combined with aminoguanidine inhibits inflammation and oxidative stress, improves vascular endothelial and retinal function and reduces VEGF expression in diabetic retinopathy patients. pimagedine 38-52 vascular endothelial growth factor A Homo sapiens 160-164 32535582-5 2020 With the introduction of aminoguanidine, a selective inhibitor of inducible NO synthase on the 18th day of pregnancy the increase in GFAP (49-37 kDa) in the cerebral hemispheres of APS mice was established, and the GFAP (total), NO2 and NO3 content did not change significantly, relative to the indicators of pregnant animals with APS. pimagedine 25-39 glial fibrillary acidic protein Mus musculus 133-137 32535582-5 2020 With the introduction of aminoguanidine, a selective inhibitor of inducible NO synthase on the 18th day of pregnancy the increase in GFAP (49-37 kDa) in the cerebral hemispheres of APS mice was established, and the GFAP (total), NO2 and NO3 content did not change significantly, relative to the indicators of pregnant animals with APS. pimagedine 25-39 glial fibrillary acidic protein Mus musculus 215-219 32535582-5 2020 With the introduction of aminoguanidine, a selective inhibitor of inducible NO synthase on the 18th day of pregnancy the increase in GFAP (49-37 kDa) in the cerebral hemispheres of APS mice was established, and the GFAP (total), NO2 and NO3 content did not change significantly, relative to the indicators of pregnant animals with APS. pimagedine 25-39 NBL1, DAN family BMP antagonist Mus musculus 238-241 31794773-9 2020 LPS exposure increased IL-6 secretion after 24 and 48 h (p < .0001), and NO at 8 and 24 h (p < .0249) via inducible nitric oxide synthase (iNOS), as demonstrated by a decrease in NO after incubation with aminoguanidine. pimagedine 204-218 nitric oxide synthase 2 Rattus norvegicus 106-137 31794773-9 2020 LPS exposure increased IL-6 secretion after 24 and 48 h (p < .0001), and NO at 8 and 24 h (p < .0249) via inducible nitric oxide synthase (iNOS), as demonstrated by a decrease in NO after incubation with aminoguanidine. pimagedine 204-218 nitric oxide synthase 2 Rattus norvegicus 139-143 32566072-6 2020 The treatments with curcumin and/or aminoguanidine increased the activities of the antioxidant enzymes (paraoxonase 1, superoxide dismutase, and catalase) and the levels of AGE detoxification system components (AGE-R1 receptor and glyoxalase 1). pimagedine 36-50 paraoxonase 1 Rattus norvegicus 104-117 32566072-6 2020 The treatments with curcumin and/or aminoguanidine increased the activities of the antioxidant enzymes (paraoxonase 1, superoxide dismutase, and catalase) and the levels of AGE detoxification system components (AGE-R1 receptor and glyoxalase 1). pimagedine 36-50 catalase Rattus norvegicus 119-153 32566072-6 2020 The treatments with curcumin and/or aminoguanidine increased the activities of the antioxidant enzymes (paraoxonase 1, superoxide dismutase, and catalase) and the levels of AGE detoxification system components (AGE-R1 receptor and glyoxalase 1). pimagedine 36-50 glyoxalase 1 Rattus norvegicus 231-243 32011309-1 2019 The aim of the research was to study the content of myelin basic protein (MBP) in the cerebellum and cerebral hemispheres of the BALB/c mice with experimental antiphospholipid syndrome as well as in cases of introduction of L-arginine and aminoguanidine. pimagedine 239-253 myelin basic protein Mus musculus 74-77 32011309-6 2019 It was found out that in the samples of the cerebral hemispheres, the content of MBP (18.4 kDa) increased in 4.8 times (p<0.001) with the use of L-arginine, in 10 times (p<0.001) - with aminoguanidine, in 13 times (p<0.001) - in cases of the combined use of L-arginine and aminoguanidine compare to the indices of the mice with antiphospholipid syndrome. pimagedine 186-200 myelin basic protein Mus musculus 81-84 32011309-6 2019 It was found out that in the samples of the cerebral hemispheres, the content of MBP (18.4 kDa) increased in 4.8 times (p<0.001) with the use of L-arginine, in 10 times (p<0.001) - with aminoguanidine, in 13 times (p<0.001) - in cases of the combined use of L-arginine and aminoguanidine compare to the indices of the mice with antiphospholipid syndrome. pimagedine 273-287 myelin basic protein Mus musculus 81-84 31775103-6 2019 In agreement, iNOS deficient mice, as well as WT mice treated with iNOS inhibitor aminoguanidine, succumbed during acute infection with a dose lethal to 50 % of the WT mice, and presented significant increase in parasite load when submitted to sub-lethal infection protocols. pimagedine 82-96 nitric oxide synthase 2, inducible Mus musculus 14-18 29788817-0 2019 Inducible nitric oxide inhibitor aminoguanidine, ameliorated oxidative stress, interleukin-6 concentration and improved brain-derived neurotrophic factor in the brain tissues of neonates born from titanium dioxide nanoparticles exposed rats. pimagedine 33-47 interleukin 6 Rattus norvegicus 79-92 29788817-0 2019 Inducible nitric oxide inhibitor aminoguanidine, ameliorated oxidative stress, interleukin-6 concentration and improved brain-derived neurotrophic factor in the brain tissues of neonates born from titanium dioxide nanoparticles exposed rats. pimagedine 33-47 brain-derived neurotrophic factor Rattus norvegicus 120-153 29788817-2 2019 The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress, and interleukin-6 (IL-6) concentrations in the brain tissues of neonates born from the rats exposed to titanium dioxide nanoparticles (TiO2 NPs) during gestation. pimagedine 61-75 nitric oxide synthase 2 Rattus norvegicus 87-108 29788817-2 2019 The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress, and interleukin-6 (IL-6) concentrations in the brain tissues of neonates born from the rats exposed to titanium dioxide nanoparticles (TiO2 NPs) during gestation. pimagedine 61-75 nitric oxide synthase 2 Rattus norvegicus 110-114 29788817-2 2019 The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress, and interleukin-6 (IL-6) concentrations in the brain tissues of neonates born from the rats exposed to titanium dioxide nanoparticles (TiO2 NPs) during gestation. pimagedine 61-75 brain-derived neurotrophic factor Rattus norvegicus 130-163 29788817-2 2019 The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress, and interleukin-6 (IL-6) concentrations in the brain tissues of neonates born from the rats exposed to titanium dioxide nanoparticles (TiO2 NPs) during gestation. pimagedine 61-75 brain-derived neurotrophic factor Rattus norvegicus 165-169 29788817-2 2019 The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress, and interleukin-6 (IL-6) concentrations in the brain tissues of neonates born from the rats exposed to titanium dioxide nanoparticles (TiO2 NPs) during gestation. pimagedine 61-75 interleukin 6 Rattus norvegicus 194-207 29788817-2 2019 The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress, and interleukin-6 (IL-6) concentrations in the brain tissues of neonates born from the rats exposed to titanium dioxide nanoparticles (TiO2 NPs) during gestation. pimagedine 61-75 interleukin 6 Rattus norvegicus 209-213 31775103-6 2019 In agreement, iNOS deficient mice, as well as WT mice treated with iNOS inhibitor aminoguanidine, succumbed during acute infection with a dose lethal to 50 % of the WT mice, and presented significant increase in parasite load when submitted to sub-lethal infection protocols. pimagedine 82-96 nitric oxide synthase 2, inducible Mus musculus 67-71 31295062-8 2019 Aminoguanidine (AMG), an AGE inhibitor, prevented the reduction in EEM, arterial elastin content, and AGE accumulation in mouse aortic segments treated with PVAT conditioned medium in the HF group. pimagedine 0-14 elastin Mus musculus 81-88 31377559-6 2019 The co-administration of aminoguanidine (iNOS inhibitor), pentoxifylline (TNFalpha inhibitor), or nicotine attenuated lipopolysaccharide mediation of renal vasodilations and elevations in alpha7/alpha4beta2-nAChR and iNOS expressions. pimagedine 25-39 nitric oxide synthase 2 Rattus norvegicus 41-45 31377559-6 2019 The co-administration of aminoguanidine (iNOS inhibitor), pentoxifylline (TNFalpha inhibitor), or nicotine attenuated lipopolysaccharide mediation of renal vasodilations and elevations in alpha7/alpha4beta2-nAChR and iNOS expressions. pimagedine 25-39 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 207-212 31377559-6 2019 The co-administration of aminoguanidine (iNOS inhibitor), pentoxifylline (TNFalpha inhibitor), or nicotine attenuated lipopolysaccharide mediation of renal vasodilations and elevations in alpha7/alpha4beta2-nAChR and iNOS expressions. pimagedine 25-39 nitric oxide synthase 2 Rattus norvegicus 217-221 31295062-8 2019 Aminoguanidine (AMG), an AGE inhibitor, prevented the reduction in EEM, arterial elastin content, and AGE accumulation in mouse aortic segments treated with PVAT conditioned medium in the HF group. pimagedine 16-19 elastin Mus musculus 81-88 30991078-0 2019 Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. pimagedine 90-104 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 18-22 31579486-3 2019 The aim of this study was to evaluate iNOS inhibitor aminoguanidine (AG) as a therapeutic agent in our mouse model of vitiligo. pimagedine 53-67 nitric oxide synthase 2, inducible Mus musculus 38-42 31272030-8 2019 Treatment with aminoguanidine inhibited fructose-induced AGEs accumulation and normalized the expression of RAGE and Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase (DDOST) in gastrocnemius muscle. pimagedine 15-29 advanced glycosylation end product-specific receptor Rattus norvegicus 108-112 31272030-8 2019 Treatment with aminoguanidine inhibited fructose-induced AGEs accumulation and normalized the expression of RAGE and Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase (DDOST) in gastrocnemius muscle. pimagedine 15-29 dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Rattus norvegicus 117-178 31272030-8 2019 Treatment with aminoguanidine inhibited fructose-induced AGEs accumulation and normalized the expression of RAGE and Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase (DDOST) in gastrocnemius muscle. pimagedine 15-29 dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Rattus norvegicus 180-185 30991078-5 2019 Repeated, but not acute, AMG administration (15 mg/kg) also decreased nitrite levels and increased TRKB phosphorylation at residues Y706/7 in the dPAG. pimagedine 25-28 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 99-103 31182088-1 2019 BACKGROUND: The present study aimed to investigate the inhibitory effects of aminoguanidine (AG) and 2-bromoethylamine (2-BEA) on the semicarbazide-sensitive amine oxidase (SSAO) activity both in vitro and in vivo, and the prevention role of AG and 2-BEA in the morphology of aorta and kidney in diabetic rats. pimagedine 77-91 amine oxidase, copper containing 3 Rattus norvegicus 134-171 30997938-9 2019 Importantly, the pharmacological inhibition of iNOS with aminoguanidine resulted in a significant increase in the numbers of amastigotes found in microglia from wild-type but not from NLRP3-/- mice, indicating the importance of NLRP3-mediated NO secretion to the infection control by these cells. pimagedine 57-71 nitric oxide synthase 2, inducible Mus musculus 47-51 31182088-1 2019 BACKGROUND: The present study aimed to investigate the inhibitory effects of aminoguanidine (AG) and 2-bromoethylamine (2-BEA) on the semicarbazide-sensitive amine oxidase (SSAO) activity both in vitro and in vivo, and the prevention role of AG and 2-BEA in the morphology of aorta and kidney in diabetic rats. pimagedine 77-91 amine oxidase, copper containing 3 Rattus norvegicus 173-177 30327173-12 2019 CONCLUSION: The findings indicated that the protective effects of AMG against LPS-induced memory were accompanied by decreasing of inflammatory cytokines, Abeta, oxidative stress and increasing of anti-inflammatory mediators and BDNF. pimagedine 66-69 amyloid beta precursor protein Rattus norvegicus 155-160 31174324-7 2019 Accordingly, MG adduct accumulation in ATC cells in vitro was associated with a marked mesenchymal phenotype and increased migration/invasion, which were both reversed by aminoguanidine (AG)-a scavenger of MG-and resveratrol-an activator of Glyoxalase 1 (Glo1), the key metabolizing enzyme of MG. pimagedine 171-185 glyoxalase I Homo sapiens 241-253 31174324-7 2019 Accordingly, MG adduct accumulation in ATC cells in vitro was associated with a marked mesenchymal phenotype and increased migration/invasion, which were both reversed by aminoguanidine (AG)-a scavenger of MG-and resveratrol-an activator of Glyoxalase 1 (Glo1), the key metabolizing enzyme of MG. pimagedine 171-185 glyoxalase I Homo sapiens 255-259 30327173-12 2019 CONCLUSION: The findings indicated that the protective effects of AMG against LPS-induced memory were accompanied by decreasing of inflammatory cytokines, Abeta, oxidative stress and increasing of anti-inflammatory mediators and BDNF. pimagedine 66-69 brain-derived neurotrophic factor Rattus norvegicus 229-233 30125695-8 2018 The pre-treatment with Aminoguanidine (50 mg/kg), a preferential inhibitor of iNOS, prevented such alterations. pimagedine 23-37 nitric oxide synthase 2, inducible Mus musculus 78-82 30395837-4 2018 Aminoguanidine, a selective iNOS inhibitor, completely suppressed serum nitrate plus nitrite (NOx) concentrations after primary and secondary sensitization of ICR mice and markedly attenuated allergy-suppressed hepatic CYP1A2, CYP2C, CYP2E1, and CYP3A activities. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 28-32 30395837-4 2018 Aminoguanidine, a selective iNOS inhibitor, completely suppressed serum nitrate plus nitrite (NOx) concentrations after primary and secondary sensitization of ICR mice and markedly attenuated allergy-suppressed hepatic CYP1A2, CYP2C, CYP2E1, and CYP3A activities. pimagedine 0-14 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 219-225 30395837-4 2018 Aminoguanidine, a selective iNOS inhibitor, completely suppressed serum nitrate plus nitrite (NOx) concentrations after primary and secondary sensitization of ICR mice and markedly attenuated allergy-suppressed hepatic CYP1A2, CYP2C, CYP2E1, and CYP3A activities. pimagedine 0-14 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 234-240 30395837-4 2018 Aminoguanidine, a selective iNOS inhibitor, completely suppressed serum nitrate plus nitrite (NOx) concentrations after primary and secondary sensitization of ICR mice and markedly attenuated allergy-suppressed hepatic CYP1A2, CYP2C, CYP2E1, and CYP3A activities. pimagedine 0-14 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 246-251 30125541-8 2018 By using gene silencing and the specific MG scavenger, aminoguanidine, the authors demonstrate that Glo1, under testosterone and follicle-stimulating hormone control, sustains viability of porcine neonatal SCs through a mechanism involving the NF-kappaB pathway. pimagedine 55-69 glyoxalase I Homo sapiens 100-104 29353375-7 2018 Furthermore, a specific inhibitor of inducible NOS (iNOS), aminoguanidine (10 microM) blocked the inhibitory action of L-cysteine on K+-evoked [3H]D-aspartate release. pimagedine 59-73 nitric oxide synthase 2 Bos taurus 37-50 30388840-1 2018 Aminoguanidine is a selective inhibitor of the inducible nitric oxide synthase (iNOS) and a scavenger of reactive oxygen species (ROS). pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 47-78 30388840-1 2018 Aminoguanidine is a selective inhibitor of the inducible nitric oxide synthase (iNOS) and a scavenger of reactive oxygen species (ROS). pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 80-84 30086070-8 2018 The iNOS and ET-1 inhibitors, aminoguanidine (20 mg/kg) and PD-142893 (0.02 mg/kg), respectively, induced significant improvements in vascular reactivity and organ perfusion and stabilized the hemodynamic parameters in rabbits subjected to endotoxic shock. pimagedine 30-44 nitric oxide synthase, inducible Oryctolagus cuniculus 4-8 30086070-8 2018 The iNOS and ET-1 inhibitors, aminoguanidine (20 mg/kg) and PD-142893 (0.02 mg/kg), respectively, induced significant improvements in vascular reactivity and organ perfusion and stabilized the hemodynamic parameters in rabbits subjected to endotoxic shock. pimagedine 30-44 endothelin-1 Oryctolagus cuniculus 13-17 29885902-5 2018 Mice were pre-treated with the selective iNOS inhibitor aminoguanidine in order to substantiate the injurious effect of the nitrosative signal on the key calcium regulator sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA2b) and calcium signalling. pimagedine 56-70 nitric oxide synthase 2, inducible Mus musculus 41-45 28942508-9 2018 Following IR, expression of iNOS and Bax increased and Bcl-2 decreased (502, 372, and 54%, respectively) in SD rats; whereas in the presence of aminoguanidine, expression of iNOS and Bax significantly decreased and Bcl-2 increased (165, 168, and 19%, respectively). pimagedine 144-158 nitric oxide synthase 2 Rattus norvegicus 28-32 28942508-9 2018 Following IR, expression of iNOS and Bax increased and Bcl-2 decreased (502, 372, and 54%, respectively) in SD rats; whereas in the presence of aminoguanidine, expression of iNOS and Bax significantly decreased and Bcl-2 increased (165, 168, and 19%, respectively). pimagedine 144-158 nitric oxide synthase 2 Rattus norvegicus 174-178 28942508-9 2018 Following IR, expression of iNOS and Bax increased and Bcl-2 decreased (502, 372, and 54%, respectively) in SD rats; whereas in the presence of aminoguanidine, expression of iNOS and Bax significantly decreased and Bcl-2 increased (165, 168, and 19%, respectively). pimagedine 144-158 BCL2 associated X, apoptosis regulator Rattus norvegicus 183-186 28942508-9 2018 Following IR, expression of iNOS and Bax increased and Bcl-2 decreased (502, 372, and 54%, respectively) in SD rats; whereas in the presence of aminoguanidine, expression of iNOS and Bax significantly decreased and Bcl-2 increased (165, 168, and 19%, respectively). pimagedine 144-158 BCL2, apoptosis regulator Rattus norvegicus 215-220 29353375-7 2018 Furthermore, a specific inhibitor of inducible NOS (iNOS), aminoguanidine (10 microM) blocked the inhibitory action of L-cysteine on K+-evoked [3H]D-aspartate release. pimagedine 59-73 nitric oxide synthase 2 Bos taurus 52-56 29363586-3 2018 Several aminoguanidine compounds, such as guanabenz, perturb the eIF2alpha phosphorylation-dephosphorylation cycle and protect different cell or tissue types from protein misfolding and degeneration. pimagedine 8-22 eukaryotic translation initiation factor 2A Mus musculus 65-74 29174818-6 2018 Diabetes also inhibited autophagy, increased ER stress and phosphorylation of pro-hypertrophic signaling molecules Akt and mTOR, the effect of which was reversed by aminoguanidine. pimagedine 165-179 thymoma viral proto-oncogene 1 Mus musculus 115-118 29174818-6 2018 Diabetes also inhibited autophagy, increased ER stress and phosphorylation of pro-hypertrophic signaling molecules Akt and mTOR, the effect of which was reversed by aminoguanidine. pimagedine 165-179 mechanistic target of rapamycin kinase Mus musculus 123-127 28946226-3 2018 When treated with aminoguanidine, the diamine oxidase and polyamine oxidase activities were almost completely inhibited, and the GABA contents decreased by 40.7%, 46.4%, 41.0% and 37.5% in the tea leaves of the four cultivars "Fuyun No. pimagedine 18-32 amine oxidase copper containing 1 Homo sapiens 38-53 28946226-3 2018 When treated with aminoguanidine, the diamine oxidase and polyamine oxidase activities were almost completely inhibited, and the GABA contents decreased by 40.7%, 46.4%, 41.0% and 37.5% in the tea leaves of the four cultivars "Fuyun No. pimagedine 18-32 polyamine oxidase Homo sapiens 58-75 29229986-8 2017 In separate experiments, the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (20 mg/kg/day, three weeks) mimicked the protective effects exerted by resveratrol in lungs of obese mice. pimagedine 78-92 nitric oxide synthase 2, inducible Mus musculus 29-60 30346862-0 2018 Aminoguanidine reverses cognitive deficits and activation of cAMP/CREB/BDNF pathway in mouse hippocampus after traumatic brain injury (TBI). pimagedine 0-14 cAMP responsive element binding protein 1 Mus musculus 66-70 30346862-0 2018 Aminoguanidine reverses cognitive deficits and activation of cAMP/CREB/BDNF pathway in mouse hippocampus after traumatic brain injury (TBI). pimagedine 0-14 brain derived neurotrophic factor Mus musculus 71-75 29229986-8 2017 In separate experiments, the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (20 mg/kg/day, three weeks) mimicked the protective effects exerted by resveratrol in lungs of obese mice. pimagedine 78-92 nitric oxide synthase 2, inducible Mus musculus 62-66 28778482-9 2017 In addition, wild-type mice treated with purified human CRP showed significant decreases in the insulin secretion index (HOMA-beta cells) and the insulin stimulation index in isolated islets that were reversed by the addition of L-NAME, aminoguanidine or NAC. pimagedine 237-251 C-reactive protein Homo sapiens 56-59 29087320-8 2017 Inhibition of NOS2 and COX2 using amino-guanidine and aspirin/indomethacin yielded an additive reduction in the growth of MDA-MB-231 tumor xenografts. pimagedine 34-49 nitric oxide synthase 2 Homo sapiens 14-18 29087320-8 2017 Inhibition of NOS2 and COX2 using amino-guanidine and aspirin/indomethacin yielded an additive reduction in the growth of MDA-MB-231 tumor xenografts. pimagedine 34-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-27 28577109-12 2017 Treatment with the iNOS inhibitor aminoguanidine aerosol by inhalation reduced the severity of phosgene-induced ALI when applied at low dose-rates. pimagedine 34-48 nitric oxide synthase 2 Rattus norvegicus 19-23 28947331-0 2017 Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. pimagedine 13-27 brain-derived neurotrophic factor Rattus norvegicus 50-54 28947331-0 2017 Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. pimagedine 13-27 mechanistic target of rapamycin kinase Rattus norvegicus 59-63 28947331-4 2017 The aim of this study was to investigate whether the behavioural effects induced by the inhibition of nitric oxide (NO) synthesis by aminoguanidine or N-methyl-D-aspartate (NMDA) receptor blockade by ketamine would affect the gene expression of Bdnf and Mtor in the ventromedial prefrontal cortex in rats. pimagedine 133-147 brain-derived neurotrophic factor Rattus norvegicus 245-249 28947331-4 2017 The aim of this study was to investigate whether the behavioural effects induced by the inhibition of nitric oxide (NO) synthesis by aminoguanidine or N-methyl-D-aspartate (NMDA) receptor blockade by ketamine would affect the gene expression of Bdnf and Mtor in the ventromedial prefrontal cortex in rats. pimagedine 133-147 mechanistic target of rapamycin kinase Rattus norvegicus 254-258 28778482-5 2017 These CRP-mediated detrimental effects on cell viability and insulin secretion were significantly reversed by adding NAC (a potent antioxidant), apocynin (a selective NADPH oxidase inhibitor), L-NAME (a non-selective nitric oxide synthase (NOS) inhibitor), aminoguanidine (a selective iNOS inhibitor), PDTC (a selective NFkappaB inhibitor) or Enbrel (an anti-TNFalpha fusion protein). pimagedine 257-271 C-reactive protein, pentraxin-related Mus musculus 6-9 28778482-5 2017 These CRP-mediated detrimental effects on cell viability and insulin secretion were significantly reversed by adding NAC (a potent antioxidant), apocynin (a selective NADPH oxidase inhibitor), L-NAME (a non-selective nitric oxide synthase (NOS) inhibitor), aminoguanidine (a selective iNOS inhibitor), PDTC (a selective NFkappaB inhibitor) or Enbrel (an anti-TNFalpha fusion protein). pimagedine 257-271 NLR family, pyrin domain containing 1A Mus musculus 117-120 28901384-9 2017 By contrast, pre-treatment with aminoguanidine for 12 h led to reduction in the mRNA and protein expression levels of COX-2. pimagedine 32-46 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 118-123 29228430-8 2017 The application of AGEs inhibitor aminoguanidine significantly improved liver functions and lower TNF-alpha or IL-6 levels when compared to the model group (p<0.05 in all cases). pimagedine 34-48 tumor necrosis factor Rattus norvegicus 98-107 29228430-8 2017 The application of AGEs inhibitor aminoguanidine significantly improved liver functions and lower TNF-alpha or IL-6 levels when compared to the model group (p<0.05 in all cases). pimagedine 34-48 interleukin 6 Rattus norvegicus 111-115 28901384-11 2017 Aminoguanidine pre-treatment also caused the inhibition of beta-amyloid-induced translocation of nuclear factor (NF)-kappaB p65 into the cytosol. pimagedine 0-14 synaptotagmin 1 Rattus norvegicus 124-127 28901384-12 2017 Thus, aminoguanidine prevented beta-amyloid-induced Alzheimer"s disease through reductions in the expression levels of NO, iNOS, PGE2 and COX-2, and the inactivation of NF-kappaB. pimagedine 6-20 nitric oxide synthase 2 Rattus norvegicus 123-127 28901384-12 2017 Thus, aminoguanidine prevented beta-amyloid-induced Alzheimer"s disease through reductions in the expression levels of NO, iNOS, PGE2 and COX-2, and the inactivation of NF-kappaB. pimagedine 6-20 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 138-143 28694192-7 2017 The expression of NOS isoforms was increased 1 h after exposure to shear stress, and AMPK phosphorylation started to increase after 2 h. AMPK and LKB1, the upstream kinases of AMPK, phosphorylation were decreased by the non-selective NOS inhibitor l-NAME and the selective iNOS inhibitor aminoguanidine despite exposure to shear stress. pimagedine 288-302 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 85-89 28634786-0 2017 Inhibition of NF-kappaB activity by aminoguanidine alleviates neuroinflammation induced by hyperglycemia. pimagedine 36-50 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 14-23 28634786-4 2017 The aim of the present study was to investigate the association of iNOS and neuroinflammation in diabetic mice, and elucidate the potential mechanisms underlying aminoguanidine (AG), the selective inhibitor of iNOS, protected neurons against inflammation in diabetic mice. pimagedine 162-176 nitric oxide synthase 2, inducible Mus musculus 67-71 28634786-4 2017 The aim of the present study was to investigate the association of iNOS and neuroinflammation in diabetic mice, and elucidate the potential mechanisms underlying aminoguanidine (AG), the selective inhibitor of iNOS, protected neurons against inflammation in diabetic mice. pimagedine 162-176 nitric oxide synthase 2, inducible Mus musculus 210-214 28757441-0 2017 Exogenous nitric oxide enhances the prophylactic effect of aminoguanidine, a preferred iNOS inhibitor, on bleomycin-induced fibrosis in the lung: Implications for the direct roles of the NO molecule in vivo. pimagedine 59-73 nitric oxide synthase 2 Rattus norvegicus 87-91 28757441-2 2017 Our previous study demonstrated that aminoguanidine (AG), a preferred iNOS inhibitor, prevents bleomycin-induced injury and fibrosis in the lung. pimagedine 37-51 nitric oxide synthase 2 Rattus norvegicus 70-74 28694192-7 2017 The expression of NOS isoforms was increased 1 h after exposure to shear stress, and AMPK phosphorylation started to increase after 2 h. AMPK and LKB1, the upstream kinases of AMPK, phosphorylation were decreased by the non-selective NOS inhibitor l-NAME and the selective iNOS inhibitor aminoguanidine despite exposure to shear stress. pimagedine 288-302 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 137-141 28694192-7 2017 The expression of NOS isoforms was increased 1 h after exposure to shear stress, and AMPK phosphorylation started to increase after 2 h. AMPK and LKB1, the upstream kinases of AMPK, phosphorylation were decreased by the non-selective NOS inhibitor l-NAME and the selective iNOS inhibitor aminoguanidine despite exposure to shear stress. pimagedine 288-302 serine/threonine kinase 11 Homo sapiens 146-150 28694192-7 2017 The expression of NOS isoforms was increased 1 h after exposure to shear stress, and AMPK phosphorylation started to increase after 2 h. AMPK and LKB1, the upstream kinases of AMPK, phosphorylation were decreased by the non-selective NOS inhibitor l-NAME and the selective iNOS inhibitor aminoguanidine despite exposure to shear stress. pimagedine 288-302 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 137-141 28704798-5 2017 Pretreatment with aminoguanidine (iNOS inhibitor) caused further reduction of adaptive immune responses and attenuated the increased NOx and 3-NT levels in CPS or CUS exposed rats. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 34-38 28242320-6 2017 Moreover, both aminoguanidine (AG, a selective inhibitor of iNOS) and diethyldithiocarbamate (DDC, a nuclear factor-kappa B (NFkappaB) inhibitor) attenuated these changes in IFN-gamma and LPS stimulated HLE cells. pimagedine 15-29 nitric oxide synthase 2 Homo sapiens 60-64 28726197-2 2017 Blockade of inducible NO synthase with aminoguanidine (single intraperitoneal dose of 50 mg/kg before stress exposure) increased coupling of respiration and oxidative phosphorylation in heart and brain mitochondria of rats exposed to immobilization-painful stress, which was especially pronounced in cardiomyocytes. pimagedine 39-53 nitric oxide synthase 2 Rattus norvegicus 12-33 29109744-2 2017 This study sought to assess the local effect of aminoguanidine (AG), a selective inducible NO synthase (iNOS) inhibitor, on the rate of bone healing. pimagedine 48-62 nitric oxide synthase 2 Rattus norvegicus 81-102 29109744-2 2017 This study sought to assess the local effect of aminoguanidine (AG), a selective inducible NO synthase (iNOS) inhibitor, on the rate of bone healing. pimagedine 48-62 nitric oxide synthase 2 Rattus norvegicus 104-108 29108256-6 2017 Treatment of aminoguanidine ameliorates the renal injury and fibrosis in STZ-induced diabetic mice and attenuated SphK1 expression and activity in diabetic mouse kidneys. pimagedine 13-27 sphingosine kinase 1 Mus musculus 114-119 28776450-8 2017 Aminoguanidine preserved lung function and shifted the Th2 to the Th1 response with a reduction of IL-4 and IL-13 and increase in IL-1beta production. pimagedine 0-14 heart and neural crest derivatives expressed 2 Mus musculus 55-58 28776450-8 2017 Aminoguanidine preserved lung function and shifted the Th2 to the Th1 response with a reduction of IL-4 and IL-13 and increase in IL-1beta production. pimagedine 0-14 negative elongation factor complex member C/D, Th1l Mus musculus 66-69 28776450-8 2017 Aminoguanidine preserved lung function and shifted the Th2 to the Th1 response with a reduction of IL-4 and IL-13 and increase in IL-1beta production. pimagedine 0-14 interleukin 4 Mus musculus 99-103 28776450-8 2017 Aminoguanidine preserved lung function and shifted the Th2 to the Th1 response with a reduction of IL-4 and IL-13 and increase in IL-1beta production. pimagedine 0-14 interleukin 13 Mus musculus 108-113 28776450-8 2017 Aminoguanidine preserved lung function and shifted the Th2 to the Th1 response with a reduction of IL-4 and IL-13 and increase in IL-1beta production. pimagedine 0-14 interleukin 1 beta Mus musculus 130-138 28099126-3 2017 This study was designed to investigate whether pretreatment with aminoguanidine (AG) - a selective iNOS inhibitor - prevents MTX-induced mucositis in rats. pimagedine 65-79 nitric oxide synthase 2 Rattus norvegicus 99-103 28242320-6 2017 Moreover, both aminoguanidine (AG, a selective inhibitor of iNOS) and diethyldithiocarbamate (DDC, a nuclear factor-kappa B (NFkappaB) inhibitor) attenuated these changes in IFN-gamma and LPS stimulated HLE cells. pimagedine 15-29 interferon gamma Homo sapiens 174-183 28077315-6 2017 In the present study, diabetic animal models were induced by streptozotocin (STZ, 150mg/kg) in mice, and aminoguanidine (AG), a selective inhibitor of iNOS, was given by intraperitoneal injection for 10 weeks. pimagedine 105-119 nitric oxide synthase 2, inducible Mus musculus 151-155 27628193-9 2017 Aminoguanidine, an iNOS inhibitor, reduced the higher NO production in DMBT1+ cells (p = 0.0476), but NO levels remained above NO production from DMBT1- cells (p = 0.0289). pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 19-23 27628193-9 2017 Aminoguanidine, an iNOS inhibitor, reduced the higher NO production in DMBT1+ cells (p = 0.0476), but NO levels remained above NO production from DMBT1- cells (p = 0.0289). pimagedine 0-14 deleted in malignant brain tumors 1 Homo sapiens 71-76 28025796-7 2017 Conversely, an iNOS inhibitor, aminoguanidine, mitigated MB+PQ-induced LPO, nitrite, iNOS, and nitro-tyrosine levels; however, no change was observed in ROS, SOD, and XO. pimagedine 31-45 nitric oxide synthase 2 Rattus norvegicus 15-19 28025796-7 2017 Conversely, an iNOS inhibitor, aminoguanidine, mitigated MB+PQ-induced LPO, nitrite, iNOS, and nitro-tyrosine levels; however, no change was observed in ROS, SOD, and XO. pimagedine 31-45 nitric oxide synthase 2 Rattus norvegicus 85-89 28065581-10 2017 Therefore, the present study shows that aminoguanidine can protect the colchicine induced neurodegeneration, memory impairments, and changes of systemic immune systemic responses in ICIR by inhibiting the iNOS. pimagedine 40-54 nitric oxide synthase 2 Rattus norvegicus 205-209 27233602-6 2016 Aminoguanidine, an iNOS inhibitor and iNOS gene silencing significantly inhibited cytokines-induced LCN-2 expression while sodium nitroprusside (SNP), an NO donor potentiated it. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 19-23 27802897-6 2016 This scratching behavior was inhibited by intraperitoneal (IP) treatment of mice with non-selective NOS inhibitor N-nitro-l-arginine methyl ester (l-NAME; 3mg/kg) and inducible NOS (iNOS) inhibitor aminoguanidine (AG; 100mg/kg). pimagedine 198-212 nitric oxide synthase 2, inducible Mus musculus 167-180 27132765-3 2016 The current study was designed to investigate the ability of the inducible NO synthase (iNOS) inhibitor aminoguanidine (AG) to counteract schizophrenia-like behavioural deficits produced by ketamine and apomorphine in rats. pimagedine 104-118 nitric oxide synthase 2 Rattus norvegicus 65-86 27132765-3 2016 The current study was designed to investigate the ability of the inducible NO synthase (iNOS) inhibitor aminoguanidine (AG) to counteract schizophrenia-like behavioural deficits produced by ketamine and apomorphine in rats. pimagedine 104-118 nitric oxide synthase 2 Rattus norvegicus 88-92 27110744-5 2016 The inhibition of TNF-alpha (pentoxifylline) or inducible nitric oxide synthase (iNOS, aminoguanidine) abolished hemodynamic, HRV, and inflammatory actions of LPS. pimagedine 87-101 nitric oxide synthase 2 Rattus norvegicus 48-79 27341994-8 2016 CONCLUSION: It is suggested that increased NO has a role in LPS-induced learning and LTP impairments and the brain tissues oxidative damage which are preventable by iNOS inhibitor aminoguanidine. pimagedine 180-194 nitric oxide synthase 2 Rattus norvegicus 165-169 27233602-6 2016 Aminoguanidine, an iNOS inhibitor and iNOS gene silencing significantly inhibited cytokines-induced LCN-2 expression while sodium nitroprusside (SNP), an NO donor potentiated it. pimagedine 0-14 lipocalin 2 Homo sapiens 100-105 25941754-7 2016 The oral administration of aminoguanidine or disulfiram, an iNOS inhibitor, attenuated the decrease in ATP levels in the retinas of 60-week-old OELTF rats. pimagedine 27-41 nitric oxide synthase 2 Rattus norvegicus 60-64 27247425-4 2016 This increase was inhibited in the presence of the nonspecific iNOS inhibitor aminoguanidine (AG). pimagedine 78-92 nitric oxide synthase 2 Homo sapiens 63-67 27129671-6 2016 Administration of aminoguanidine (specific iNOS inhibitor, 20mg/kg) augmented the protective effects of tropisetron (1mg/kg) on SIS. pimagedine 18-32 nitric oxide synthase 2, inducible Mus musculus 43-47 27056913-6 2016 Aminoguanidine-treated diabetic mice displayed decreased AGE modification of plasma albumin, accompanied by a reduced level of albumin in the circulating immune complexes. pimagedine 0-14 albumin Mus musculus 84-91 27056913-6 2016 Aminoguanidine-treated diabetic mice displayed decreased AGE modification of plasma albumin, accompanied by a reduced level of albumin in the circulating immune complexes. pimagedine 0-14 albumin Mus musculus 127-134 27056913-7 2016 In addition, elevated levels of proinflammatory cytokines such as IL-1b, IL-2, and TNF-alpha were observed in diabetes, which were reduced with aminoguanidine treatment, suggesting the involvement of glycation in the immune response. pimagedine 144-158 interleukin 1 beta Mus musculus 66-71 27056913-7 2016 In addition, elevated levels of proinflammatory cytokines such as IL-1b, IL-2, and TNF-alpha were observed in diabetes, which were reduced with aminoguanidine treatment, suggesting the involvement of glycation in the immune response. pimagedine 144-158 interleukin 2 Mus musculus 73-77 27056913-7 2016 In addition, elevated levels of proinflammatory cytokines such as IL-1b, IL-2, and TNF-alpha were observed in diabetes, which were reduced with aminoguanidine treatment, suggesting the involvement of glycation in the immune response. pimagedine 144-158 tumor necrosis factor Mus musculus 83-92 27210113-0 2016 Effect of chronic intraperitoneal aminoguanidine on memory and expression of Bcl-2 family genes in diabetic rats. pimagedine 34-48 BCL2, apoptosis regulator Rattus norvegicus 77-82 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 50-54 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 95-99 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 BCL2 associated X, apoptosis regulator Rattus norvegicus 104-107 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 BCL2, apoptosis regulator Rattus norvegicus 136-141 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 95-99 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 BCL2 associated X, apoptosis regulator Rattus norvegicus 182-185 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 BCL2, apoptosis regulator Rattus norvegicus 213-218 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 95-99 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 BCL2 associated X, apoptosis regulator Rattus norvegicus 182-185 27074518-12 2016 After IR, in FH rats, aminoguanidine, a selective iNOS inhibitor, decreased mRNA expression of iNOS and Bax and increased expression of Bcl-2 in both young (65% and 58% for iNOS and Bax, respectively and 152% for Bcl-2) and aged rats (76% and 64% for iNOS and Bax, respectively and 222% for Bcl-2). pimagedine 22-36 BCL2, apoptosis regulator Rattus norvegicus 213-218 27074518-13 2016 In addition, in the heart of FH rats, aminoguanidine decreased protein levels of iNOS (47% for young and 60% for aged rats) and Bax (57% for young and 80% for aged rats) and increased protein levels of Bcl-2 (124% for young and 180% for aged rats). pimagedine 38-52 nitric oxide synthase 2 Rattus norvegicus 81-85 27074518-13 2016 In addition, in the heart of FH rats, aminoguanidine decreased protein levels of iNOS (47% for young and 60% for aged rats) and Bax (57% for young and 80% for aged rats) and increased protein levels of Bcl-2 (124% for young and 180% for aged rats). pimagedine 38-52 BCL2 associated X, apoptosis regulator Rattus norvegicus 128-131 27074518-13 2016 In addition, in the heart of FH rats, aminoguanidine decreased protein levels of iNOS (47% for young and 60% for aged rats) and Bax (57% for young and 80% for aged rats) and increased protein levels of Bcl-2 (124% for young and 180% for aged rats). pimagedine 38-52 BCL2, apoptosis regulator Rattus norvegicus 202-207 26724393-0 2016 Aminoguanidine treatment increased NOX2 response in diabetic rats: Improved phagocytosis and killing of Candida albicans by neutrophils. pimagedine 0-14 cytochrome b-245 beta chain Rattus norvegicus 35-39 26724393-1 2016 In this study, we show that aminoguanidine (AMG), an inhibitor of protein glycation, increases the NOX2 (phagocyte NADPH oxidase) response and microbicidal activity by neutrophils, regardless of diabetic status. pimagedine 28-42 cytochrome b-245 beta chain Rattus norvegicus 99-103 26724393-1 2016 In this study, we show that aminoguanidine (AMG), an inhibitor of protein glycation, increases the NOX2 (phagocyte NADPH oxidase) response and microbicidal activity by neutrophils, regardless of diabetic status. pimagedine 44-47 cytochrome b-245 beta chain Rattus norvegicus 99-103 26925135-7 2016 Compared with the diabetes group, the content of inflammatory cytokines TNF-alpha, IL-8, ICAM and IL-1alpha was dramatically lower in the aminoguanidine group. pimagedine 138-152 tumor necrosis factor Rattus norvegicus 72-81 26925135-7 2016 Compared with the diabetes group, the content of inflammatory cytokines TNF-alpha, IL-8, ICAM and IL-1alpha was dramatically lower in the aminoguanidine group. pimagedine 138-152 intercellular adhesion molecule 1 Rattus norvegicus 89-93 26925135-10 2016 CONCLUSIONS: Aminoguanidine may have a good systemic effect on alleviating the pathological changes of skin tissue in diabetic rats, which may be attributed to the regulation of GSH-PX, TNF-alpha, IL-8, ICAM and IL-1alpha. pimagedine 13-27 tumor necrosis factor Rattus norvegicus 186-195 26925135-10 2016 CONCLUSIONS: Aminoguanidine may have a good systemic effect on alleviating the pathological changes of skin tissue in diabetic rats, which may be attributed to the regulation of GSH-PX, TNF-alpha, IL-8, ICAM and IL-1alpha. pimagedine 13-27 intercellular adhesion molecule 1 Rattus norvegicus 203-207 26925135-7 2016 Compared with the diabetes group, the content of inflammatory cytokines TNF-alpha, IL-8, ICAM and IL-1alpha was dramatically lower in the aminoguanidine group. pimagedine 138-152 interleukin 1 alpha Rattus norvegicus 98-107 26925135-10 2016 CONCLUSIONS: Aminoguanidine may have a good systemic effect on alleviating the pathological changes of skin tissue in diabetic rats, which may be attributed to the regulation of GSH-PX, TNF-alpha, IL-8, ICAM and IL-1alpha. pimagedine 13-27 interleukin 1 alpha Rattus norvegicus 212-221 26925135-9 2016 The activities of GSH-PX and MPO and content of H2O2 in the diabetes group were all higher than those in the aminoguanidine group. pimagedine 109-123 glutathione peroxidase 1 Rattus norvegicus 18-24 26925135-9 2016 The activities of GSH-PX and MPO and content of H2O2 in the diabetes group were all higher than those in the aminoguanidine group. pimagedine 109-123 myeloperoxidase Rattus norvegicus 29-32 26925135-10 2016 CONCLUSIONS: Aminoguanidine may have a good systemic effect on alleviating the pathological changes of skin tissue in diabetic rats, which may be attributed to the regulation of GSH-PX, TNF-alpha, IL-8, ICAM and IL-1alpha. pimagedine 13-27 glutathione peroxidase 1 Rattus norvegicus 178-184 26268932-12 2016 Acute NOS inhibition using either Nomega-nitro-l-arginine methyl ester (a non-specific NOS inhibitor) or aminoguanidine hydrochloride (a specific iNOS inhibitor) decreased the immobility time in colitic groups. pimagedine 105-133 nitric oxide synthase 2, inducible Mus musculus 146-150 26690069-5 2016 Aminoguanidine (AG; iNOS inhibitor) decreased NO production with delay in development of clinical signs and increase in survival time. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 20-24 28478405-8 2016 The administration of aminoguanidine, an iNOS inhibitor, (20 mg/kg, twice a week during the experiment) increases arginase and ornithine decarboxylase activities, and the administration of L-arginine (500 mg/kg, twice a week) results in the increase of arginase activity. pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 41-45 26614409-2 2016 Herein, we report a novel class of allylidene hydrazinecarboximidamide derivatives as moderately potent BACE-1 inhibitors, having aminoguanidine substitution on allyl linker with two aromatic groups on either side. pimagedine 130-144 beta-secretase 1 Homo sapiens 104-110 28478405-8 2016 The administration of aminoguanidine, an iNOS inhibitor, (20 mg/kg, twice a week during the experiment) increases arginase and ornithine decarboxylase activities, and the administration of L-arginine (500 mg/kg, twice a week) results in the increase of arginase activity. pimagedine 22-36 ornithine decarboxylase 1 Rattus norvegicus 127-150 27717924-8 2016 The administration of aminoguanidine, an iNOS inhibitor, (20 mg/kg, twice a week during the experiment) increases arginase and ornithine decarboxylase activities, and the administration of L-arginine (500 mg/kg, twice a week) results in the increase of arginase activity. pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 41-45 26318599-10 2015 Nuclear exit of Abeta, accumulated during growth in aminoguanidine, was enhanced by ascorbate-induced reactivation of anMan-HS production. pimagedine 52-66 amyloid beta (A4) precursor protein Mus musculus 16-21 27717924-8 2016 The administration of aminoguanidine, an iNOS inhibitor, (20 mg/kg, twice a week during the experiment) increases arginase and ornithine decarboxylase activities, and the administration of L-arginine (500 mg/kg, twice a week) results in the increase of arginase activity. pimagedine 22-36 ornithine decarboxylase 1 Rattus norvegicus 127-150 26110531-6 2015 Its IC50 value (87.88 +- 3.08 muM) was almost two times lower than the standard anti-glycation compound aminoguanidine (184.68 +- 4.85 muM). pimagedine 104-118 latexin Homo sapiens 30-33 26513461-7 2015 The general NOS inhibitor L-NAME and the iNOS specific inhibitor aminoguanidine prevented these effects in both models. pimagedine 65-79 nitric oxide synthase 2 Homo sapiens 41-45 26318599-3 2015 To further examine the relationship between APP and Gpc-1 processing in normal fibroblasts we have suppressed Gpc-1 autodegradation by aminoguanidine inhibition of NO synthesis and prevented lysosomal degradation of anMan-HS by using chloroquine. pimagedine 135-149 glypican 1 Mus musculus 110-115 26641046-4 2015 Tissue was pretreated with or without aminoguanidine and amodiaquine to block the histamine-degrading enzymes diamine oxidase (DAO) and histamine -methyltransferase (HMT), respectively. pimagedine 38-52 amine oxidase copper containing 1 Sus scrofa 127-130 25971874-11 2015 Colitis-induced amnesia was also inhibited by aminoguanidine (50 mg/kg), implicating a role for iNOS activation and neuroinflammation in this phenomenon. pimagedine 46-60 nitric oxide synthase 2, inducible Mus musculus 96-100 26110531-6 2015 Its IC50 value (87.88 +- 3.08 muM) was almost two times lower than the standard anti-glycation compound aminoguanidine (184.68 +- 4.85 muM). pimagedine 104-118 latexin Homo sapiens 135-138 25758466-12 2015 Additionally, AMG, a selective inhibitor of iNOS, reduced Co-60-induced oral mucositis through reducing NO production. pimagedine 14-17 nitric oxide synthase 2 Homo sapiens 44-48 24683106-3 2015 This study was designed to assess the role of aminoguanidine (AG, a selective inhibitor of iNOS), in healing at the colonic anastomotic site after intestinal I-R injury in rats. pimagedine 46-60 nitric oxide synthase 2 Rattus norvegicus 91-95 28911384-5 2015 Aminoguanidine reduced over 85% of diamine oxidase activity, and 33.28% and 36.35% of GABA content in cotyledon and embryo, respectively. pimagedine 0-14 copper amino oxidase Glycine max 35-50 25406100-10 2015 Furthermore, Nano-TiO2-induced renal injury could be mitigated by iNOS inhibitor aminoguanidine and ROS scavenger N-acetylcysteine treatment in transcription level. pimagedine 81-95 nitric oxide synthase 2, inducible Mus musculus 66-70 25933980-1 2015 BACKGROUND: beta-Resorcylidene aminoguanidine (RAG), a highly reactive derivative of aminoguanidine, possesses antithrombotic activity which involves the activation of the vascular COX-2/PGI2 pathway. pimagedine 31-45 cytochrome c oxidase II, mitochondrial Rattus norvegicus 181-186 24666836-8 2015 Aminoguanidine"s effects revealed that small concentrations (10 mumol/L) enhance AGE-BSA effects, by increasing the expression of RAGE and TGF-beta1, while higher concentrations (100 mumol/L) contribute to their downregulation. pimagedine 0-14 long intergenic non-protein coding RNA 914 Homo sapiens 130-134 25481849-5 2015 The high glucose-induced upregulation of GAL-3 was attenuated by cotreatment with 0.2mM of an anti-glycated agent aminoguanidine or 20nM of an anti-oxidant trans-resveratrol. pimagedine 114-128 galectin 3 Rattus norvegicus 41-46 23628005-9 2015 Our in vivo studies show that MnTBAP and aminoguanidine treatment of DOX and BPS co-administered in mice can attenuate caspase-3 and PARP-1 protein expression, and improve mouse survival, as observed in the iNOS gene-deleted mice. pimagedine 41-55 caspase 3 Mus musculus 119-128 23628005-9 2015 Our in vivo studies show that MnTBAP and aminoguanidine treatment of DOX and BPS co-administered in mice can attenuate caspase-3 and PARP-1 protein expression, and improve mouse survival, as observed in the iNOS gene-deleted mice. pimagedine 41-55 poly (ADP-ribose) polymerase family, member 1 Mus musculus 133-139 23628005-9 2015 Our in vivo studies show that MnTBAP and aminoguanidine treatment of DOX and BPS co-administered in mice can attenuate caspase-3 and PARP-1 protein expression, and improve mouse survival, as observed in the iNOS gene-deleted mice. pimagedine 41-55 nitric oxide synthase 2, inducible Mus musculus 207-211 25191931-11 2015 iNOS inhibitor (aminoguanidine) added to the drinking water for 5 weeks reduced the production of iNOS and osteonecrosis compared to a control group without aminoguanidine. pimagedine 16-30 nitric oxide synthase 2 Rattus norvegicus 0-4 25191931-11 2015 iNOS inhibitor (aminoguanidine) added to the drinking water for 5 weeks reduced the production of iNOS and osteonecrosis compared to a control group without aminoguanidine. pimagedine 16-30 nitric oxide synthase 2 Rattus norvegicus 98-102 25191931-11 2015 iNOS inhibitor (aminoguanidine) added to the drinking water for 5 weeks reduced the production of iNOS and osteonecrosis compared to a control group without aminoguanidine. pimagedine 157-171 nitric oxide synthase 2 Rattus norvegicus 0-4 25351957-12 2015 The iNOS selective inhibitor, aminoguanidine, partially reversed the LPS-induced ALDH2 activity decrease and MPTP opening. pimagedine 30-44 nitric oxide synthase 2 Rattus norvegicus 4-8 25351957-12 2015 The iNOS selective inhibitor, aminoguanidine, partially reversed the LPS-induced ALDH2 activity decrease and MPTP opening. pimagedine 30-44 aldehyde dehydrogenase 2 family member Rattus norvegicus 81-86 25635819-9 2015 Blockade of pro-inflammatory cytokines and the overproduction of NO induced by co-treatment with pentoxifylline and LPS and iNOS inhibition with aminoguanidine both extended down-regulation of CYP2A5 to the high dose range while not affecting LPS-induced depression of CYP1A and CYP2B. pimagedine 145-159 nitric oxide synthase 2, inducible Mus musculus 124-128 25635819-9 2015 Blockade of pro-inflammatory cytokines and the overproduction of NO induced by co-treatment with pentoxifylline and LPS and iNOS inhibition with aminoguanidine both extended down-regulation of CYP2A5 to the high dose range while not affecting LPS-induced depression of CYP1A and CYP2B. pimagedine 145-159 cytochrome P450, family 2, subfamily a, polypeptide 5 Mus musculus 193-199 25635819-9 2015 Blockade of pro-inflammatory cytokines and the overproduction of NO induced by co-treatment with pentoxifylline and LPS and iNOS inhibition with aminoguanidine both extended down-regulation of CYP2A5 to the high dose range while not affecting LPS-induced depression of CYP1A and CYP2B. pimagedine 145-159 cytochrome P450, family 2, subfamily b, polypeptide 10 Mus musculus 279-284 25664261-3 2015 In this study, we evaluated the effect of inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG), on hemodynamic parameters and serum nitrite concentration in decompensated hemorrhagic shock model in normotensive and hypertensive male rats. pimagedine 82-96 nitric oxide synthase 2 Rattus norvegicus 42-63 24666836-8 2015 Aminoguanidine"s effects revealed that small concentrations (10 mumol/L) enhance AGE-BSA effects, by increasing the expression of RAGE and TGF-beta1, while higher concentrations (100 mumol/L) contribute to their downregulation. pimagedine 0-14 transforming growth factor beta 1 Homo sapiens 139-148 25400165-5 2014 On the other hand, aminoguanidine and cysteine led to the highest reaction control ratios for the PTT-xylose/xylooligosaccharide (160.0 and 143.0) and PTT-galactooligosaccharides/galactan (663.0 and 71.0) reaction systems, respectively. pimagedine 19-33 Patatin class I Solanum tuberosum 98-101 25234194-3 2015 Following 120 min of bilateral microdialysis of a selective iNOS antagonist, aminoguanidine (AGN; 10 microM), into the RVLM, the pressor responses were attenuated by 72 % and changes in heart rate were reduced by 38 % during a static muscle contraction. pimagedine 77-91 nitric oxide synthase 2 Rattus norvegicus 60-64 25234194-3 2015 Following 120 min of bilateral microdialysis of a selective iNOS antagonist, aminoguanidine (AGN; 10 microM), into the RVLM, the pressor responses were attenuated by 72 % and changes in heart rate were reduced by 38 % during a static muscle contraction. pimagedine 93-96 nitric oxide synthase 2 Rattus norvegicus 60-64 26199466-6 2015 The effect of IL-17A (0.1-1 ng/mL) was sensitive to the iNOS-selective inhibitor aminoguanidine and undetectable in iNOS-/- bone-marrow. pimagedine 81-95 interleukin 17A Homo sapiens 14-20 26199466-6 2015 The effect of IL-17A (0.1-1 ng/mL) was sensitive to the iNOS-selective inhibitor aminoguanidine and undetectable in iNOS-/- bone-marrow. pimagedine 81-95 nitric oxide synthase 2 Homo sapiens 56-60 25400165-6 2014 The use of cysteine and aminoguanidine as inhibitors led to 1.7-99.4% decreases in the particle size distribution of the PTT conjugates and to 0.4-9.3% increases in their relative digestibility, per 5% blocked lysine. pimagedine 24-38 Patatin class I Solanum tuberosum 121-124 24909615-8 2014 Whereas iNOS activity was inhibited by aminoguanidine, cellular MnSOD levels as well as mitochondrial membrane potentials were upregulated, and consequentially G2/M arrest and apoptosis were thoroughly reversed. pimagedine 39-53 nitric oxide synthase 2 Homo sapiens 8-12 25149996-10 2014 Pre-treatment with aminoguanidine (50mg/kg, ip), an inducible nitric oxide synthase (NOS) inhibitor, significantly potentiated the anxiolytic-like activity of piperine, as compared to piperine and aminoguanidine alone in stressed mice. pimagedine 19-33 nitric oxide synthase 1, neuronal Mus musculus 62-83 25297558-9 2014 Aminoguanidine administration decreased the expression of iNOS and RITC extravasation after smoke inhalation. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 58-62 25224370-2 2014 The aim of the present study was to investigate the potential protective effect of l-arginine (Arg; nitric oxide precursor) and aminoguanidine (inducible nitric oxide synthase inhibitor) against acetic acid (AA)-induced colitis in rats, and the potential role of NF-kappaB. pimagedine 128-142 nitric oxide synthase 2 Rattus norvegicus 144-175 25257408-3 2014 A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. pimagedine 48-62 nitric oxide synthase 2 Rattus norvegicus 25-46 24819503-9 2014 Aminoguanidine treatment decreased PMN infiltration, iNOS mRNA expression and MPO activity. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 53-57 25505863-0 2014 The Effect of Systemic Delivery of Aminoguanidine versus Doxycycline on the Resorptive Phase of Alveolar Bone Following modified Widman Flap in Diabetic Rats: A Histopathological and Scanning Electron Microscope (SEM) study. pimagedine 35-49 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 136-140 25505863-2 2014 The aim of the present study was to evaluate the effectiveness of aminoguanidine versus doxycycline in reducing alveolar bone resorption following mucoperiosteal flap in diabetic rats, using the conventional histopathology and scanning electron microscope (SEM). pimagedine 66-80 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 162-166 24662848-6 2014 The pretreatment with the NOS inhibitors, l-NAME and aminoguanidine as well as sildenafil prevented the behavioral and neurochemical alterations induced by LPS, although sildenafil and l-NAME were not able to prevent the increase in hippocampal BDNF levels induced by LPS. pimagedine 53-67 brain derived neurotrophic factor Mus musculus 245-249 24819503-9 2014 Aminoguanidine treatment decreased PMN infiltration, iNOS mRNA expression and MPO activity. pimagedine 0-14 myeloperoxidase Rattus norvegicus 78-81 23855839-0 2014 Aminoguanidine inhibits the AGE-RAGE axis to modulate the induction of periodontitis but has limited effects on the progression and recovery of experimental periodontitis: a preliminary study. pimagedine 0-14 advanced glycosylation end product-specific receptor Rattus norvegicus 32-36 23760255-3 2014 The aim of the present study was to examine the effects of aminoguanidine, selective inhibitor of inducible NO synthase (iNOS), on HT-induced seizures. pimagedine 59-73 nitric oxide synthase 2 Rattus norvegicus 98-119 23760255-3 2014 The aim of the present study was to examine the effects of aminoguanidine, selective inhibitor of inducible NO synthase (iNOS), on HT-induced seizures. pimagedine 59-73 nitric oxide synthase 2 Rattus norvegicus 121-125 23760255-10 2014 It could be concluded that iNOS inhibitor (aminoguanidine) markedly aggravates behavioral and EEG manifestations of HT-induced seizures in rats, showing functional involvement of iNOS in homocysteine convulsive mechanisms. pimagedine 43-57 nitric oxide synthase 2 Rattus norvegicus 27-31 23760255-10 2014 It could be concluded that iNOS inhibitor (aminoguanidine) markedly aggravates behavioral and EEG manifestations of HT-induced seizures in rats, showing functional involvement of iNOS in homocysteine convulsive mechanisms. pimagedine 43-57 nitric oxide synthase 2 Rattus norvegicus 179-183 24671193-8 2014 In contrast, aminoguanidine (AG) (an inducible NOS (iNOS) inhibitor) had less effect on either cerebral vasodilation or BBB disruption. pimagedine 13-27 nitric oxide synthase 2, inducible Mus musculus 37-50 25360396-2 2014 The reported utility of aminoguanidine and nitroarginine in iNOS inhibition points to a potential similar utility for analogs of nitro-guanidine. pimagedine 24-38 nitric oxide synthase 2 Homo sapiens 60-64 24326522-2 2014 The objective of this study was to examine whether bilateral intrahippocampal CA1 (intra-CA1) injection of aminoguanidine (AG) can either affect the Bcl-2 family gene expression or reduce the diabetic imposing abnormalities of passive avoidance learning (PAL) and memory. pimagedine 107-121 carbonic anhydrase 1 Rattus norvegicus 78-81 24326522-2 2014 The objective of this study was to examine whether bilateral intrahippocampal CA1 (intra-CA1) injection of aminoguanidine (AG) can either affect the Bcl-2 family gene expression or reduce the diabetic imposing abnormalities of passive avoidance learning (PAL) and memory. pimagedine 107-121 carbonic anhydrase 1 Rattus norvegicus 89-92 24326522-2 2014 The objective of this study was to examine whether bilateral intrahippocampal CA1 (intra-CA1) injection of aminoguanidine (AG) can either affect the Bcl-2 family gene expression or reduce the diabetic imposing abnormalities of passive avoidance learning (PAL) and memory. pimagedine 107-121 BCL2, apoptosis regulator Rattus norvegicus 149-154 23602911-6 2013 Furthermore, the effects of arsenite on PARP-1 activity, DNA binding, and zinc content were partially reversed by the antioxidant ascorbic acid, catalase, and the NOS inhibitor, aminoguanidine. pimagedine 178-192 poly(ADP-ribose) polymerase 1 Homo sapiens 40-46 23921152-10 2013 It may be concluded that arsenic induces endothelial dysfunction and dementia, whereas, sodium butyrate, a HDAC inhibitor as well as aminoguanidine, a selective iNOS inhibitor may be considered as potential agents for the management of arsenic induced endothelial dysfunction and dementia. pimagedine 133-147 nitric oxide synthase 2 Rattus norvegicus 161-165 24550965-4 2013 Aminoguanidine is a selective inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 43-74 24550965-4 2013 Aminoguanidine is a selective inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 76-80 24586149-8 2014 This induction was dependent on inducible nitric oxide synthase (iNOS) activation, as treatment of macrophages with an inhibitor of iNOS, aminoguanidine, significantly decreased IL-33-induced NO release. pimagedine 138-152 nitric oxide synthase 2, inducible Mus musculus 65-69 24586149-8 2014 This induction was dependent on inducible nitric oxide synthase (iNOS) activation, as treatment of macrophages with an inhibitor of iNOS, aminoguanidine, significantly decreased IL-33-induced NO release. pimagedine 138-152 nitric oxide synthase 2, inducible Mus musculus 132-136 24586149-8 2014 This induction was dependent on inducible nitric oxide synthase (iNOS) activation, as treatment of macrophages with an inhibitor of iNOS, aminoguanidine, significantly decreased IL-33-induced NO release. pimagedine 138-152 interleukin 33 Mus musculus 178-183 24586149-9 2014 Moreover, aminoguanidine significantly blocked the capacity of IL-33 to inhibit the growth of S. aureus, and IL-33 silencing in macrophages significantly increased the survival of S. aureus in macrophages. pimagedine 10-24 interleukin 33 Mus musculus 63-68 24117259-2 2013 This study investigated the influence of pre- or post-treatment with aminoguanidine as a selective iNOS inhibitor on UUO-induced renal functional disturbances. pimagedine 69-83 nitric oxide synthase 2 Rattus norvegicus 99-103 24204674-13 2013 In separate experiments, the selective iNOS inhibitor aminoguanidine (20 mg/kg, 3 weeks) and the anti-TNF-alpha mAb (2 mg/kg) significantly attenuated the aggravation of eosinophilic inflammation in obese mice. pimagedine 54-68 nitric oxide synthase 2, inducible Mus musculus 39-43 23483583-8 2013 In addition, inhibition of LPS-induced nitric oxide production by aminoguanidine, a selective NOS2 inhibitor, significantly reduced LPS-mediated LCN2 expression. pimagedine 66-80 nitric oxide synthase 2, inducible Mus musculus 94-98 23624268-6 2013 Inhibition of total nitric oxide synthase (NOS) by administration of nitro-l-arginine methyl ester (L-NAME) and inducible NOS (iNOS) by aminoguanidine (AG) in HFD and HFD+ beta-sitosterol groups were accomplished to identify the role of NO. pimagedine 136-150 nitric oxide synthase 2 Rattus norvegicus 127-131 23483583-8 2013 In addition, inhibition of LPS-induced nitric oxide production by aminoguanidine, a selective NOS2 inhibitor, significantly reduced LPS-mediated LCN2 expression. pimagedine 66-80 lipocalin 2 Mus musculus 145-149 23483583-10 2013 Intriguingly, SNP addition to LPS-challenged chondrocytes, treated with aminoguanidine, provoked a strong induction of LCN2 expression. pimagedine 72-86 lipocalin 2 Mus musculus 119-123 22998024-7 2012 The pathology of colitis and increases in colonic MPO activity, P-selectin, ICAM-1, and TNF-alpha levels were suppressed by the inducible NO synthase (iNOS)-specific inhibitor aminoguanidine and NO scavenger c-PTIO, whereas all but TNF-alpha levels were increased by the non-specific NOS inhibitor L-NAME. pimagedine 176-190 myeloperoxidase Mus musculus 50-53 23354458-7 2013 Treating diabetic rats with pyridoxamine (a scavenger of reactive carbonyl species, RCS) or aminoguanidine (a mixed reactive oxygen species-RCS scavenger) reduced CML, pentosidine, and pyrraline adducts on RyR2 and SERCA2 and blunted SR Ca(2+) cycling changes. pimagedine 92-106 ryanodine receptor 2 Rattus norvegicus 206-210 23354458-7 2013 Treating diabetic rats with pyridoxamine (a scavenger of reactive carbonyl species, RCS) or aminoguanidine (a mixed reactive oxygen species-RCS scavenger) reduced CML, pentosidine, and pyrraline adducts on RyR2 and SERCA2 and blunted SR Ca(2+) cycling changes. pimagedine 92-106 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 215-221 23248291-6 2013 Both endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) expression were increased after LPS challenge in mice with endothelial GR deficiency, and aminoguanidine, a specific iNOS inhibitor in mice was able to rescue hemodynamic collapse in these animals. pimagedine 179-193 nitric oxide synthase 2, inducible Mus musculus 50-81 23248291-6 2013 Both endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) expression were increased after LPS challenge in mice with endothelial GR deficiency, and aminoguanidine, a specific iNOS inhibitor in mice was able to rescue hemodynamic collapse in these animals. pimagedine 179-193 nitric oxide synthase 2, inducible Mus musculus 206-210 22902472-6 2013 The reduction reaction of HMP in septic mouse heads was remarkably accelerated compared to that in control mice, and this accelerated reaction was inhibited by aminoguanidine and allopurinol, which inhibit enzymatic activities of induced nitric oxide synthase and xanthine oxidase, respectively. pimagedine 160-174 xanthine dehydrogenase Mus musculus 264-280 23563031-9 2013 L-NAME, a non-selective inhibitor of nitric oxide synthase, decreased pioglitazone-induced gastric healing effect in cirrhotic rats, while aminoguanidine, a selective inducible nitric oxide synthase inhibitor, increased pioglitazone-induced gastric healing effect in the same group. pimagedine 139-153 nitric oxide synthase 2 Rattus norvegicus 167-198 23524183-6 2013 The occurrence of anticonvulsant activity of GSE was significantly delayed in the presence of selective inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (60 mg/kg), which was inhibited by the NO precursor, L-arginine (500 mg/kg). pimagedine 154-168 nitric oxide synthase 2 Rattus norvegicus 104-135 23524183-6 2013 The occurrence of anticonvulsant activity of GSE was significantly delayed in the presence of selective inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (60 mg/kg), which was inhibited by the NO precursor, L-arginine (500 mg/kg). pimagedine 154-168 nitric oxide synthase 2 Rattus norvegicus 137-141 23801613-6 2013 Aminoguanidine (1 mmol/L) inhibited methylglyoxal and OGD induced LDH release and Annexin V/PI formation. pimagedine 0-14 annexin A5 Homo sapiens 82-91 22998024-7 2012 The pathology of colitis and increases in colonic MPO activity, P-selectin, ICAM-1, and TNF-alpha levels were suppressed by the inducible NO synthase (iNOS)-specific inhibitor aminoguanidine and NO scavenger c-PTIO, whereas all but TNF-alpha levels were increased by the non-specific NOS inhibitor L-NAME. pimagedine 176-190 selectin, platelet Mus musculus 64-74 22998024-7 2012 The pathology of colitis and increases in colonic MPO activity, P-selectin, ICAM-1, and TNF-alpha levels were suppressed by the inducible NO synthase (iNOS)-specific inhibitor aminoguanidine and NO scavenger c-PTIO, whereas all but TNF-alpha levels were increased by the non-specific NOS inhibitor L-NAME. pimagedine 176-190 intercellular adhesion molecule 1 Mus musculus 76-82 22998024-7 2012 The pathology of colitis and increases in colonic MPO activity, P-selectin, ICAM-1, and TNF-alpha levels were suppressed by the inducible NO synthase (iNOS)-specific inhibitor aminoguanidine and NO scavenger c-PTIO, whereas all but TNF-alpha levels were increased by the non-specific NOS inhibitor L-NAME. pimagedine 176-190 tumor necrosis factor Mus musculus 88-97 22998024-7 2012 The pathology of colitis and increases in colonic MPO activity, P-selectin, ICAM-1, and TNF-alpha levels were suppressed by the inducible NO synthase (iNOS)-specific inhibitor aminoguanidine and NO scavenger c-PTIO, whereas all but TNF-alpha levels were increased by the non-specific NOS inhibitor L-NAME. pimagedine 176-190 nitric oxide synthase 2, inducible Mus musculus 128-149 22998024-7 2012 The pathology of colitis and increases in colonic MPO activity, P-selectin, ICAM-1, and TNF-alpha levels were suppressed by the inducible NO synthase (iNOS)-specific inhibitor aminoguanidine and NO scavenger c-PTIO, whereas all but TNF-alpha levels were increased by the non-specific NOS inhibitor L-NAME. pimagedine 176-190 nitric oxide synthase 2, inducible Mus musculus 151-155 23000243-14 2012 The emphysema was attenuated when iNOS was inhibited using 1% AMG and in iNOS knockout mice. pimagedine 62-65 nitric oxide synthase 2, inducible Mus musculus 34-38 22863952-6 2012 IEC p53 levels and apoptosis were reduced in IL-10(-/-) colitic mice treated with neutralizing TNF mAb and the iNOS inhibitor, aminoguanidine, further suggesting that TNF and iNOS are upstream of p53 during colitis-induced IEC apoptosis. pimagedine 127-141 nitric oxide synthase 2, inducible Mus musculus 111-115 22798221-7 2012 Aminoguanidine, a blocker of AGEs formation, could effectively reverse the MG-induced tau hyperphosphorylation. pimagedine 0-14 microtubule associated protein tau Homo sapiens 86-89 22955317-9 2012 Isolated CD11b(+)CD14(+) cells suppressed CD8(+) T-cell proliferation and IFN-gamma production, and the former effect was attenuated by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine hydrochloride, arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA), and blocking antibodies for IL-4Ralpha(+) and IL-10. pimagedine 189-217 integrin subunit alpha M Homo sapiens 9-14 22955317-9 2012 Isolated CD11b(+)CD14(+) cells suppressed CD8(+) T-cell proliferation and IFN-gamma production, and the former effect was attenuated by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine hydrochloride, arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA), and blocking antibodies for IL-4Ralpha(+) and IL-10. pimagedine 189-217 CD14 molecule Homo sapiens 17-21 22955317-9 2012 Isolated CD11b(+)CD14(+) cells suppressed CD8(+) T-cell proliferation and IFN-gamma production, and the former effect was attenuated by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine hydrochloride, arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA), and blocking antibodies for IL-4Ralpha(+) and IL-10. pimagedine 189-217 CD8a molecule Homo sapiens 42-45 22955317-9 2012 Isolated CD11b(+)CD14(+) cells suppressed CD8(+) T-cell proliferation and IFN-gamma production, and the former effect was attenuated by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine hydrochloride, arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA), and blocking antibodies for IL-4Ralpha(+) and IL-10. pimagedine 189-217 interferon gamma Homo sapiens 74-83 22955317-9 2012 Isolated CD11b(+)CD14(+) cells suppressed CD8(+) T-cell proliferation and IFN-gamma production, and the former effect was attenuated by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine hydrochloride, arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA), and blocking antibodies for IL-4Ralpha(+) and IL-10. pimagedine 189-217 nitric oxide synthase 2 Homo sapiens 173-177 22955317-9 2012 Isolated CD11b(+)CD14(+) cells suppressed CD8(+) T-cell proliferation and IFN-gamma production, and the former effect was attenuated by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine hydrochloride, arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA), and blocking antibodies for IL-4Ralpha(+) and IL-10. pimagedine 189-217 interleukin 4 receptor Homo sapiens 303-326 22863952-6 2012 IEC p53 levels and apoptosis were reduced in IL-10(-/-) colitic mice treated with neutralizing TNF mAb and the iNOS inhibitor, aminoguanidine, further suggesting that TNF and iNOS are upstream of p53 during colitis-induced IEC apoptosis. pimagedine 127-141 transformation related protein 53, pseudogene Mus musculus 4-7 22863952-6 2012 IEC p53 levels and apoptosis were reduced in IL-10(-/-) colitic mice treated with neutralizing TNF mAb and the iNOS inhibitor, aminoguanidine, further suggesting that TNF and iNOS are upstream of p53 during colitis-induced IEC apoptosis. pimagedine 127-141 interleukin 10 Mus musculus 45-50 23022527-11 2012 These changes, including AMH levels, in d-gal-treated mice were inhibited by aminoguanidine treatment, an advanced glycation end product reducer. pimagedine 77-91 anti-Mullerian hormone Mus musculus 25-28 22687049-11 2012 Defective glucose-stimulated insulin release upon induction of iNOS was restored by iNOS inhibitor aminoguanidine. pimagedine 99-113 insulin Homo sapiens 29-36 22687049-11 2012 Defective glucose-stimulated insulin release upon induction of iNOS was restored by iNOS inhibitor aminoguanidine. pimagedine 99-113 nitric oxide synthase 2 Homo sapiens 63-67 22687049-11 2012 Defective glucose-stimulated insulin release upon induction of iNOS was restored by iNOS inhibitor aminoguanidine. pimagedine 99-113 nitric oxide synthase 2 Homo sapiens 84-88 22374887-11 2012 Administration of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, attenuated all parameters of colitis as well as the reductions in Complex IV and Complex II activity. pimagedine 18-32 nitric oxide synthase 2, inducible Mus musculus 37-68 22374887-11 2012 Administration of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, attenuated all parameters of colitis as well as the reductions in Complex IV and Complex II activity. pimagedine 18-32 nitric oxide synthase 2, inducible Mus musculus 70-74 22863952-6 2012 IEC p53 levels and apoptosis were reduced in IL-10(-/-) colitic mice treated with neutralizing TNF mAb and the iNOS inhibitor, aminoguanidine, further suggesting that TNF and iNOS are upstream of p53 during colitis-induced IEC apoptosis. pimagedine 127-141 tumor necrosis factor Mus musculus 167-170 22863952-6 2012 IEC p53 levels and apoptosis were reduced in IL-10(-/-) colitic mice treated with neutralizing TNF mAb and the iNOS inhibitor, aminoguanidine, further suggesting that TNF and iNOS are upstream of p53 during colitis-induced IEC apoptosis. pimagedine 127-141 nitric oxide synthase 2, inducible Mus musculus 175-179 22863952-6 2012 IEC p53 levels and apoptosis were reduced in IL-10(-/-) colitic mice treated with neutralizing TNF mAb and the iNOS inhibitor, aminoguanidine, further suggesting that TNF and iNOS are upstream of p53 during colitis-induced IEC apoptosis. pimagedine 127-141 transformation related protein 53, pseudogene Mus musculus 196-199 22584260-4 2012 The antinociceptive effect of amitriptyline, not clomipramine, was augmented by the selective iNOS inhibitor, aminoguanidine. pimagedine 110-124 nitric oxide synthase 2 Rattus norvegicus 94-98 22699114-7 2012 Aminoguanidine reduced hepatic lipid peroxidation and protein expression levels of iNOS, nitrotyrosine and p65. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 83-87 22699114-7 2012 Aminoguanidine reduced hepatic lipid peroxidation and protein expression levels of iNOS, nitrotyrosine and p65. pimagedine 0-14 synaptotagmin 1 Rattus norvegicus 107-110 22699114-9 2012 In addition, aminoguanidine reduced the expression of p65 in the liver. pimagedine 13-27 synaptotagmin 1 Rattus norvegicus 54-57 22445558-2 2012 The effect of feeding curcumin, quercetin and aminoguanidine on lysosomal enzyme activities viz., N-acetyl-beta-d-glucosaminidase, beta-d-glucuronidase, beta-d-galactosidase and acid phosphatase were studied in different tissues of streptozotocin-induced diabetic rats. pimagedine 46-60 O-GlcNAcase Rattus norvegicus 98-129 22512358-4 2012 The skin lipid peroxidation, and NO levels evaluated by chemiluminescence and inducible nitric oxide synthase (iNOS) and nitrotyrosine immunolabelling increased significantly 24 hours after irradiation and decreased under the treatment with aminoguanidine (AG). pimagedine 241-255 nitric oxide synthase 2 Homo sapiens 78-109 22860427-1 2012 OBJECTIVE: To explore the effects of intrathecal injection of neuronal nitric oxide synthase (nNOS) inhibitors 7-Nitroindazole (7-Ni) and inducible nitric oxide synthase(iNOS) inhibitors aminoguanidine (AG) on the behavioral changes of morphine-induced dependent and withdrawal rats; the expression of Fos, nNOS and iNOS in spinal cord. pimagedine 187-201 nitric oxide synthase 2 Rattus norvegicus 138-169 22271422-8 2012 Aminoguanidine prevented ROS elevation and restored the ABCA-1 content in macrophages; on the other hand, benfotiamine that promoted a lesser reduction in ROS generation was not able to restore ABCA-1 levels. pimagedine 0-14 ATP binding cassette subfamily A member 1 Homo sapiens 56-62 21907687-12 2012 Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression. pimagedine 17-31 advanced glycosylation end-product specific receptor Homo sapiens 89-93 22101361-10 2012 The rise in MPO, smooth muscle over-contractility, and diarrhea were abrogated in aminoguanidine-treated and iNOS(-/-) mice. pimagedine 82-96 myeloperoxidase Mus musculus 12-15 21907687-12 2012 Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression. pimagedine 17-31 serpin family E member 1 Homo sapiens 95-100 21907687-12 2012 Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression. pimagedine 17-31 C-X-C motif chemokine ligand 8 Homo sapiens 102-106 21907687-12 2012 Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression. pimagedine 17-31 interleukin 6 Homo sapiens 108-112 21956123-4 2012 The CML-modified insoluble elastin became resistant to neutrophil elastase digestion, which was reversed by treatment with aminoguanidine, a potent inhibitor of AGE formation. pimagedine 123-137 elastin Homo sapiens 27-34 22690838-8 2012 An eNOS inhibitor (N(omega)-nitro-L-arginine methyl ester (L-NAME)), or an iNOS inhibitor (aminoguanidine (AG)), significantly aggravated the liver injury. pimagedine 91-105 nitric oxide synthase 2 Rattus norvegicus 75-79 22291637-5 2011 Changes in retinal arteriole diameter were measured following diffuse flickering light stimulation in control rats, streptozotocin-induced type 1 diabetic rats and diabetic rats treated with aminoguanidine (AG; an iNOS inhibitor), either acutely via IV injection or chronically in drinking water. pimagedine 191-205 nitric oxide synthase 2 Rattus norvegicus 214-218 23207775-5 2012 The expression of inducible nitric oxide synthase (iNOS) mRNA and nitric oxide (NO) production in the gastric mucosa of AA rats were also increased by the administration of loxoprofen, and the increase in lesions and NO were prevented by the administration of aminoguanidine, an iNOS inhibitor. pimagedine 260-274 nitric oxide synthase 2 Rattus norvegicus 18-49 23207775-5 2012 The expression of inducible nitric oxide synthase (iNOS) mRNA and nitric oxide (NO) production in the gastric mucosa of AA rats were also increased by the administration of loxoprofen, and the increase in lesions and NO were prevented by the administration of aminoguanidine, an iNOS inhibitor. pimagedine 260-274 nitric oxide synthase 2 Rattus norvegicus 51-55 21710130-3 2012 Bilateral microdialysis of a selective iNOS inhibitor, aminoguanidine (AGN; 10 muM), into the dlPAG for 30 min augmented MAP and HR responses during a mechanical stimulation. pimagedine 55-69 nitric oxide synthase 2 Rattus norvegicus 39-43 21710130-3 2012 Bilateral microdialysis of a selective iNOS inhibitor, aminoguanidine (AGN; 10 muM), into the dlPAG for 30 min augmented MAP and HR responses during a mechanical stimulation. pimagedine 71-74 nitric oxide synthase 2 Rattus norvegicus 39-43 22036766-0 2012 Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-alpha-induced oxidative stress, colitis and hepatotoxicity in mice. pimagedine 0-14 tumor necrosis factor Mus musculus 39-72 22745717-8 2012 This effect was largely reversed by aminoguanidine (AG), an iNOS inhibitor. pimagedine 36-50 nitric oxide synthase 2, inducible Mus musculus 60-64 21939674-7 2012 1400W but not NPA, when administered at equivalent doses considering the magnitude of their Ki values for iNOS and nNOS, respectively, reduced the IT, thus suggesting that aminoguanidine-induced effects would be due to selective iNOS inhibition. pimagedine 172-186 nitric oxide synthase 2, inducible Mus musculus 229-233 22293693-10 2012 The decrease in the intestinal P-gp expression levels were suppressed by aminoguanidine, a specific iNOS inhibitor. pimagedine 73-87 phosphoglycolate phosphatase Mus musculus 31-35 22063504-0 2011 Controversial behavior of aminoguanidine in the presence of either reducing sugars or soluble glycated bovine serum albumin. pimagedine 26-40 albumin Homo sapiens 110-123 22493895-6 2012 Inducible nitric oxide synthase (iNOS) inhibitors aminoguanidine (AG) was intrathecally injected 30 min before the administration of naloxone. pimagedine 50-64 nitric oxide synthase 2 Rattus norvegicus 0-31 22493895-6 2012 Inducible nitric oxide synthase (iNOS) inhibitors aminoguanidine (AG) was intrathecally injected 30 min before the administration of naloxone. pimagedine 50-64 nitric oxide synthase 2 Rattus norvegicus 33-37 22063504-1 2011 The elucidation of the controversial inhibitory effect of aminoguanidine (AG) on the cross-linking and fluorescent advanced glycation end products (AGEs) formation during long-term in vitro glycation of type I collagen with 250 mM reducing sugars or 0.5mg/ml soluble glycated bovine serum albumin (AGE-BSA) was researched. pimagedine 58-72 albumin Homo sapiens 283-296 21712628-0 2011 Use of aminoguanidine, a selective inducible nitric oxide synthase inhibitor, to evaluate the role of nitric oxide in periapical inflammation. pimagedine 7-21 nitric oxide synthase 2 Canis lupus familiaris 35-66 22135691-0 2011 The use of aminoguanidine, a selective inducible nitric oxide synthase inhibitor, to evaluate the role of nitric oxide on periapical healing. pimagedine 11-25 nitric oxide synthase 2 Canis lupus familiaris 39-70 22135691-3 2011 The purpose of this study was to evaluate the effect of aminoguanidine (AG) as a selective inhibitor of inducible nitric oxide synthase (iNOS) on the degree of healing response of periapical lesions of the canine teeth of cats. pimagedine 56-70 nitric oxide synthase 2 Canis lupus familiaris 104-135 22135691-3 2011 The purpose of this study was to evaluate the effect of aminoguanidine (AG) as a selective inhibitor of inducible nitric oxide synthase (iNOS) on the degree of healing response of periapical lesions of the canine teeth of cats. pimagedine 56-70 nitric oxide synthase 2 Canis lupus familiaris 137-141 21481476-5 2011 Importantly, the treatment in vivo of diabetic rats with etanercept (TNF-alpha blocking antibody) or aminoguanidine (selective iNOS inhibitor) significantly attenuated the induction of apoptosis by reduction of caspase-3 activity. pimagedine 101-115 nitric oxide synthase 2 Rattus norvegicus 127-131 21481476-5 2011 Importantly, the treatment in vivo of diabetic rats with etanercept (TNF-alpha blocking antibody) or aminoguanidine (selective iNOS inhibitor) significantly attenuated the induction of apoptosis by reduction of caspase-3 activity. pimagedine 101-115 caspase 3 Rattus norvegicus 211-220 21864526-9 2011 Increased apoptosis and levels of Bax in mast cells from diabetic rats were inhibited by aminoguanidine. pimagedine 89-103 BCL2 associated X, apoptosis regulator Rattus norvegicus 34-37 21417589-3 2011 METHODS: Oral aminoguanidine (an iNOS inhibitor) or water treatment was started 2 weeks before induction of periodontitis. pimagedine 14-28 nitric oxide synthase 2 Rattus norvegicus 33-37 22145410-1 2011 The rats liver and kidneys function indices were studied in case of administration of recombinant superoxide dismutase drug, precursor of nitric oxide L-arginine and the blocker of inducible NO-synthase aminoguanidine. pimagedine 203-217 nitric oxide synthase 2 Rattus norvegicus 181-202 21712628-1 2011 The purpose of this study was to evaluate the effects of aminoguanidine (AG) as a selective inhibitor of inducible nitric oxide synthase (iNOS) on the degree of inflammatory response in periapical lesions in the canine teeth of cats. pimagedine 57-71 nitric oxide synthase 2 Canis lupus familiaris 105-136 21712628-1 2011 The purpose of this study was to evaluate the effects of aminoguanidine (AG) as a selective inhibitor of inducible nitric oxide synthase (iNOS) on the degree of inflammatory response in periapical lesions in the canine teeth of cats. pimagedine 57-71 nitric oxide synthase 2 Canis lupus familiaris 138-142 21134443-4 2011 Therefore, in the present study, we examined changes in the tight junctions (TJ) and P-glycoprotein (P-gp) by aminoguanidine (AG), which can be considered a selective inducible NO synthase inhibitor during intestinal I/R, to clarify the effect of NO on mucosal barrier dysfunction during intestinal I/R. pimagedine 110-124 ATP binding cassette subfamily B member 1 Homo sapiens 85-99 21437951-8 2011 Aminoguanidine significantly reversed the changes in alginate beads induced by IL-1beta treatment. pimagedine 0-14 interleukin 1 beta Homo sapiens 79-87 21467785-11 2011 The decrease of P-gp expression levels observed on day 9 was completely suppressed by L-NG-nitroarginine methyl ester (L-NAME), a broad range NOS inhibitor, or aminoguanidine, a specific inducible NOS (iNOS) inhibitor. pimagedine 160-174 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 21467785-11 2011 The decrease of P-gp expression levels observed on day 9 was completely suppressed by L-NG-nitroarginine methyl ester (L-NAME), a broad range NOS inhibitor, or aminoguanidine, a specific inducible NOS (iNOS) inhibitor. pimagedine 160-174 nitric oxide synthase 2 Homo sapiens 202-206 21220562-1 2011 PURPOSE: To investigate how OPA1 expression and distribution are altered by increased nitric oxide (NO) and whether aminoguanidine, a relative selective NO synthase (NOS)-2 inhibitor, can restore OPA1 expression and subsequently increase retinal ganglion cell (RGC) survival in ocular hypertensive rats. pimagedine 116-130 OPA1, mitochondrial dynamin like GTPase Rattus norvegicus 196-200 21220562-8 2011 Aminoguanidine treatment significantly reduced expression of the 90- and 65-kDa OPA1 isoforms but did not significantly change the 80-kDa OPA1 isoform in hypertensive retina. pimagedine 0-14 OPA1, mitochondrial dynamin like GTPase Rattus norvegicus 80-84 21220562-9 2011 In addition, the increases in NOS-2 and GFAP protein expression were blocked by aminoguanidine treatment in the hypertensive retina. pimagedine 80-94 nitric oxide synthase 2 Rattus norvegicus 30-35 21220562-9 2011 In addition, the increases in NOS-2 and GFAP protein expression were blocked by aminoguanidine treatment in the hypertensive retina. pimagedine 80-94 glial fibrillary acidic protein Rattus norvegicus 40-44 21502683-0 2011 Aminoguanidine potentiates the hepatoprotective effect of silymarin in CCL4 treated rats. pimagedine 0-14 C-C motif chemokine ligand 4 Rattus norvegicus 71-75 21500983-2 2011 This study aimed at investigating the effects of ocular administration of aminoguanidine (AMG), a multiple action DAO and NOS inhibitor, on the conjunctival histamine and nitrite levels in a model of experimental conjunctivitis. pimagedine 74-88 amine oxidase, copper containing 1 Rattus norvegicus 114-117 21500983-2 2011 This study aimed at investigating the effects of ocular administration of aminoguanidine (AMG), a multiple action DAO and NOS inhibitor, on the conjunctival histamine and nitrite levels in a model of experimental conjunctivitis. pimagedine 90-93 amine oxidase, copper containing 1 Rattus norvegicus 114-117 21203836-1 2011 The effects of a selective inducible nitric oxide synthase inhibitor aminoguanidine (AG) on neuronal cells survival in hippocampal CA1 region after middle cerebral artery occlusion (MCAO) were examined. pimagedine 69-83 carbonic anhydrase 1 Rattus norvegicus 131-134 21203836-5 2011 The number of degenerating neurons in hippocampal CA1 region was also markedly lower in aminoguanidine-treated ischemic groups compared to ischemic groups without AG-treatment. pimagedine 88-102 carbonic anhydrase 1 Rattus norvegicus 50-53 21134443-4 2011 Therefore, in the present study, we examined changes in the tight junctions (TJ) and P-glycoprotein (P-gp) by aminoguanidine (AG), which can be considered a selective inducible NO synthase inhibitor during intestinal I/R, to clarify the effect of NO on mucosal barrier dysfunction during intestinal I/R. pimagedine 110-124 ATP binding cassette subfamily B member 1 Homo sapiens 101-105 22040888-4 2011 Wistar/ST rats were exposed to 1 h of ischemia, followed by reperfusion for 4 h. The rats were intravenously injected with 100 mg/kg aminoguanidine (AG), which is a selective inducible NO synthase (iNOS) inhibitor, for 5 min before ischemia. pimagedine 133-147 nitric oxide synthase 2 Rattus norvegicus 175-196 22040888-4 2011 Wistar/ST rats were exposed to 1 h of ischemia, followed by reperfusion for 4 h. The rats were intravenously injected with 100 mg/kg aminoguanidine (AG), which is a selective inducible NO synthase (iNOS) inhibitor, for 5 min before ischemia. pimagedine 133-147 nitric oxide synthase 2 Rattus norvegicus 198-202 21206910-9 2010 In addition, some rats were injected with aminoguanidine (AG), an inducible isoform inhibitor of NO synthase (iNOS), 24 h before and 4 h after sStx2 injection. pimagedine 42-56 nitric oxide synthase 2 Rattus norvegicus 110-114 21893984-0 2011 Aminoguanidine, a selective nitric oxide synthase inhibitor, attenuates cyclophosphamide-induced renal damage by inhibiting protein nitration and poly(ADP-Ribose) polymerase activation. pimagedine 0-14 poly (ADP-ribose) polymerase 1 Rattus norvegicus 146-173 22553657-0 2011 Effect of aminoguanidine on caspase-3 expression in rat retina after ischemia-reperfusion injury. pimagedine 10-24 caspase 3 Rattus norvegicus 28-37 22553657-1 2011 AIM: To investigate the effect of aminoguanidine (AG) on the expression of caspase-3 in rat retina after ischemia- reperfusion injury. pimagedine 34-48 caspase 3 Rattus norvegicus 75-84 21071988-9 2011 Administration of the iNOS inhibitor aminoguanidine did not significantly change NOS activity, suggesting that the activity found in the cerebellum and pons can be attributed to the cNOS isoform. pimagedine 37-51 nitric oxide synthase 2 Homo sapiens 22-26 21878740-8 2011 The increase in the analgesic effects of morphine, as well as serum and brain morphine content, was suppressed by aminoguanidine, a specific iNOS inhibitor. pimagedine 114-128 nitric oxide synthase 2, inducible Mus musculus 141-145 21067926-1 2010 Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles. pimagedine 47-61 tankyrase Homo sapiens 0-6 20826152-8 2010 TRPV1 activation also increased GFAP expression, which was reverted by both TRPV1 antagonism with capsazepine and by 7-NI and aminoguanidine. pimagedine 126-140 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 20826152-8 2010 TRPV1 activation also increased GFAP expression, which was reverted by both TRPV1 antagonism with capsazepine and by 7-NI and aminoguanidine. pimagedine 126-140 glial fibrillary acidic protein Rattus norvegicus 32-36 20643487-8 2010 Aminoguanidine pretreatment resulted in increased MAP in the early phase and higher AVP(R) in the supraoptic, but not in the paraventricular nucleus, while AVPp remained elevated at all time points. pimagedine 0-14 arginine vasopressin Rattus norvegicus 84-87 20460580-11 2010 Finally, glycation inhibitor aminoguanidine administration during MG treatment of cultured cells reduced AGE formation, increased Trx activity, restored Trx-ASK1 interaction, and reduced p38 MAPK phosphorylation and activity, caspase-3 activation, and LDH release (P < 0.01). pimagedine 29-43 thioredoxin Homo sapiens 130-133 20460580-11 2010 Finally, glycation inhibitor aminoguanidine administration during MG treatment of cultured cells reduced AGE formation, increased Trx activity, restored Trx-ASK1 interaction, and reduced p38 MAPK phosphorylation and activity, caspase-3 activation, and LDH release (P < 0.01). pimagedine 29-43 thioredoxin Homo sapiens 153-156 20460580-11 2010 Finally, glycation inhibitor aminoguanidine administration during MG treatment of cultured cells reduced AGE formation, increased Trx activity, restored Trx-ASK1 interaction, and reduced p38 MAPK phosphorylation and activity, caspase-3 activation, and LDH release (P < 0.01). pimagedine 29-43 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 157-161 20460580-11 2010 Finally, glycation inhibitor aminoguanidine administration during MG treatment of cultured cells reduced AGE formation, increased Trx activity, restored Trx-ASK1 interaction, and reduced p38 MAPK phosphorylation and activity, caspase-3 activation, and LDH release (P < 0.01). pimagedine 29-43 mitogen-activated protein kinase 14 Homo sapiens 187-190 20460580-11 2010 Finally, glycation inhibitor aminoguanidine administration during MG treatment of cultured cells reduced AGE formation, increased Trx activity, restored Trx-ASK1 interaction, and reduced p38 MAPK phosphorylation and activity, caspase-3 activation, and LDH release (P < 0.01). pimagedine 29-43 caspase 3 Homo sapiens 226-235 20206261-7 2010 Aminoguanidine (AG) significantly inhibited mRNA and protein expressions of iNOS, but not that of eNOS. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 76-80 20416371-8 2010 Aminoguanidine, a competitive glycation-inhibitor, completely blocked the inhibitory effect of LPS on Trx-1. pimagedine 0-14 thioredoxin Homo sapiens 102-107 20455021-8 2010 Aminoguanidine resulted in a significant attenuation of iNOS mRNA expression, nitrite content and lipid peroxidation demonstrating the involvement of nitric oxide in MB- and PQ-induced lipid peroxidation. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 56-60 20224425-5 2010 In another study, 7 healthy volunteers were given selective inducible NO synthase inhibitor aminoguanidine intravenous continuously from 1 hour after a single LPS administration until 5 hours. pimagedine 92-106 nitric oxide synthase 2 Homo sapiens 60-81 20224425-8 2010 Our data demonstrate that endothelial dysfunction caused by endotoxemia does not occur when endotoxin tolerance develops, indicated by the absence of cytokine production and during administration of selective inducible NO synthase inhibitor aminoguanidine in vivo. pimagedine 241-255 nitric oxide synthase 2 Homo sapiens 209-230 20417245-8 2010 Furthermore, co-administration of alpha-lipoic acid and aminoguanidine restore superoxide dismutase, catalase and myeloperoxidase activities and maintained the imbalance in the glutathione level. pimagedine 56-70 catalase Rattus norvegicus 101-109 20417245-8 2010 Furthermore, co-administration of alpha-lipoic acid and aminoguanidine restore superoxide dismutase, catalase and myeloperoxidase activities and maintained the imbalance in the glutathione level. pimagedine 56-70 myeloperoxidase Rattus norvegicus 114-129 20093483-5 2010 Treatment with an iNOS specific inhibitor, aminoguanidine (AG), of wild-type animals before infection prevented the development of bacteremia and the occurrence of meningitis. pimagedine 43-57 nitric oxide synthase 2, inducible Mus musculus 18-22 20338478-8 2010 Both effects could be neutralized by aminoguanidine, a metabolic iNOS inhibitor. pimagedine 37-51 nitric oxide synthase 2, inducible Mus musculus 65-69 19932725-7 2010 injections of aminoguanidine (AG), a selective inducible nitric oxide synthase (iNOS) inhibitor. pimagedine 14-28 nitric oxide synthase 2 Rattus norvegicus 47-78 19932725-7 2010 injections of aminoguanidine (AG), a selective inducible nitric oxide synthase (iNOS) inhibitor. pimagedine 14-28 nitric oxide synthase 2 Rattus norvegicus 80-84 20097209-10 2010 The decrease of P-gp expression levels observed on the 9th day was completely suppressed by L-N(G)-nitroarginine methyl ester (L-NAME), a broad range NOS inhibitor, or aminoguanidine, a specific inducible NOS (iNOS) inhibitor. pimagedine 168-182 phosphoglycolate phosphatase Mus musculus 16-20 20097209-10 2010 The decrease of P-gp expression levels observed on the 9th day was completely suppressed by L-N(G)-nitroarginine methyl ester (L-NAME), a broad range NOS inhibitor, or aminoguanidine, a specific inducible NOS (iNOS) inhibitor. pimagedine 168-182 nitric oxide synthase 2, inducible Mus musculus 210-214 20056078-9 2010 Aminoguanidine prevents the islets from the damage of iNOS, alleviates the impairment of cytokines to islets, lessens the cell apoptosis and ameliorates the survival and function of islets. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 54-58 19783894-9 2010 Aminoguanidine was used as a selective inhibitor of iNOS to reduce the derivation of ONOO-. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 52-56 20116408-0 2010 Neuroprotective actions of aminoguanidine involve reduced the activation of calpain and caspase-3 in a rat model of stroke. pimagedine 27-41 caspase 3 Rattus norvegicus 88-97 20116408-3 2010 The present study investigated whether aminoguanidine (AG), an iNOS inhibitor, protected brain against experimental stroke through inhibiting calpain and caspase-3 activation. pimagedine 39-53 nitric oxide synthase 2 Rattus norvegicus 63-67 20116408-3 2010 The present study investigated whether aminoguanidine (AG), an iNOS inhibitor, protected brain against experimental stroke through inhibiting calpain and caspase-3 activation. pimagedine 39-53 caspase 3 Rattus norvegicus 154-163 19838638-13 2010 The decrease in FE(NO) after aminoguanidine and subsequent partial reversal by L-arginine in both groups, suggests that Type II NOS contributes to the FE(NO) in both. pimagedine 29-43 nitric oxide synthase 2 Homo sapiens 120-131 19893025-4 2009 The high glucose-induced activation of beta-catenin was attenuated by aminoguanidine, suggesting that oxidative stress is a direct cause for the Wnt pathway activation in diabetes. pimagedine 70-84 catenin beta 1 Homo sapiens 39-51 20209289-10 2009 CONCLUSION: unspecific cNOS block with L-NAME and relatively specific iNOS block with aminoguanidine results leads us to propose that depending on the pathway, the NO can increase or reduce mucociliary transport in frog palates. pimagedine 86-100 nitric oxide synthase 2 Homo sapiens 70-74 19720799-9 2009 Glycation of fibronectin also decreased preconditioned neurite outgrowth, which was prevented by aminoguanidine and nerve growth factor. pimagedine 97-111 fibronectin 1 Rattus norvegicus 13-24 20065509-4 2009 Pretreatment with L-NAME (a nonselective inhibitor of NOS) and aminoguanidine (a relative selective inhibitor of iNOS) did not affect the ulcerogenic response in normal rats but dose-dependently prevented the aggravation of lesions in arthritic rats, but the effect of aminoguanidine was apparently less than that of L-NAME. pimagedine 63-77 nitric oxide synthase 2 Rattus norvegicus 113-117 19967660-4 2009 METHODS: Diabetes was induced in Sprague Dawley rats by an intraperitoneal injection of streptozocin, and aminoguanidine was used as selective inhibitor of iNOS. pimagedine 106-120 nitric oxide synthase 2 Rattus norvegicus 156-160 19967660-10 2009 Aminoguanidine was found to inhibit iNOS and then reduce ONOO(-) overformation, attenuating the pathological alterations. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 36-40 20084944-4 2009 RESULTS: 1) Inducible NOS (iNos) activity and NO content in model group was significantly higher (F = 522.860, P < 0.01), in acupotomology group and aminoguanidine group was significantly lower than the model group (FiNOS = 28.894, P < 0.01), and iNOS activity and NO content in all groups was in competence with the condition of soft tissue injuries. pimagedine 152-166 nitric oxide synthase 2 Rattus norvegicus 12-25 20084944-4 2009 RESULTS: 1) Inducible NOS (iNos) activity and NO content in model group was significantly higher (F = 522.860, P < 0.01), in acupotomology group and aminoguanidine group was significantly lower than the model group (FiNOS = 28.894, P < 0.01), and iNOS activity and NO content in all groups was in competence with the condition of soft tissue injuries. pimagedine 152-166 nitric oxide synthase 2 Rattus norvegicus 27-31 20084944-4 2009 RESULTS: 1) Inducible NOS (iNos) activity and NO content in model group was significantly higher (F = 522.860, P < 0.01), in acupotomology group and aminoguanidine group was significantly lower than the model group (FiNOS = 28.894, P < 0.01), and iNOS activity and NO content in all groups was in competence with the condition of soft tissue injuries. pimagedine 152-166 nitric oxide synthase 2 Rattus norvegicus 220-224 19572977-3 2009 In the present study, the effects of an iNOS inhibitor, aminoguanidine (AG), on thyroid carcinogenesis were examined. pimagedine 56-70 nitric oxide synthase 2 Rattus norvegicus 40-44 19701588-0 2009 [Inhalation of aminoguanidine prevents the up-regulation of connective tissue growth factor in fibrotic lungs of rats]. pimagedine 15-29 cellular communication network factor 2 Rattus norvegicus 60-91 19672189-8 2009 Aminoguanidine, an iNOS inhibitor, also attenuated this decreased cell viability. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 19-23 19605546-9 2009 Aminoguanidine effectively prevented downregulation of podocalyxin protein levels but could not restore podocalyxin levels once expression was suppressed. pimagedine 0-14 podocalyxin like Homo sapiens 55-66 19605546-11 2009 Administration of aminoguanidine concomitant with increasing glucose levels in our in vitro model system protected from glucose-induced "silencing" of the podocalyxin gene, suggesting that AGEs play an important role in suppressing its expression in diabetic conditions. pimagedine 18-32 podocalyxin like Homo sapiens 155-166 19701588-2 2009 The purpose of the present study was to explore the effects of inhalation of aminoguanidine (AG) on the up-regulation of CTGF in fibrotic lungs of rats. pimagedine 77-91 cellular communication network factor 2 Rattus norvegicus 121-125 19597524-7 2009 mRNA and protein expression of MMP-9, PKCepsilon, NADPH oxidase and ERG in the LV, S, and RV were obviously dispersed, with augmented expression mainly in the LV and S. Dispersed parameters were re-harmonized by either CPU0213, or aminoguanidine. pimagedine 231-245 matrix metallopeptidase 9 Rattus norvegicus 31-36 19246537-9 2009 Blocking the formation of nitric oxide with an iNOS selective inhibitor aminoguanidine reversed the inhibitory effects of AGEs on ATP production and insulin secretion. pimagedine 72-86 nitric oxide synthase 2, inducible Mus musculus 47-51 19330319-3 2009 Treatment with the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine or vitamin E could prevent the impairment in contractile responses of both ends to EFS and phenylephrine but sodium selenate could restore these impaired contractions at only the epididymal end. pimagedine 68-82 nitric oxide synthase 2 Rattus norvegicus 19-50 19330319-3 2009 Treatment with the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine or vitamin E could prevent the impairment in contractile responses of both ends to EFS and phenylephrine but sodium selenate could restore these impaired contractions at only the epididymal end. pimagedine 68-82 nitric oxide synthase 2 Rattus norvegicus 52-56 19885009-8 2009 However, pretreatment with aminoguanidine significantly suppressed both the KA-induced and L-NAME-aggravated hippocampal CA3 neuronal death with concomitant decreases in iNOS expression and microglial activation. pimagedine 27-41 carbonic anhydrase 3 Mus musculus 121-124 19885009-8 2009 However, pretreatment with aminoguanidine significantly suppressed both the KA-induced and L-NAME-aggravated hippocampal CA3 neuronal death with concomitant decreases in iNOS expression and microglial activation. pimagedine 27-41 nitric oxide synthase 2, inducible Mus musculus 170-174 19301028-0 2009 Suppression of retinal neovascularization by the iNOS inhibitor aminoguanidine in mice of oxygen-induced retinopathy. pimagedine 64-78 nitric oxide synthase 2, inducible Mus musculus 49-53 19301028-2 2009 Our study was focused on evaluating the inhibitory effect of aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS), on retinal NV in mice of oxygen-induced retinopathy (OIR). pimagedine 61-75 nitric oxide synthase 2, inducible Mus musculus 98-129 19301028-2 2009 Our study was focused on evaluating the inhibitory effect of aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS), on retinal NV in mice of oxygen-induced retinopathy (OIR). pimagedine 61-75 nitric oxide synthase 2, inducible Mus musculus 131-135 18838940-6 2009 Rats were treated with the nonselective NO synthase (NOS) inhibitor L-NAME (N(omega)-nitro-L-arginine methyl ester) or with the selective inhibitor of iNOS aminoguanidine 1 h before superior mesenteric artery occlusion. pimagedine 156-170 nitric oxide synthase 2 Rattus norvegicus 151-155 19359223-10 2009 The Fos count after systemic LPS was reduced to 99+/-30 following pretreatment with the cyclooxygenase inhibitor Naproxen (10 mg kg(-1); p>0.05 versus vehicle controls) and increased to 242+/-66 following the iNOS-inhibitor Aminoguanidine (15 mg kg(-1); p<0.01). pimagedine 227-241 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 4-7 19184353-6 2009 Histamine fluxes accounted for <25 % of hist-rad fluxes, but this percentage increased after blocking HMT (100 microM amodiaquin) or DAO (100 microM aminoguanidine). pimagedine 152-166 histamine N-methyltransferase Sus scrofa 105-108 19061877-7 2009 Furthermore, reactive oxygen species inhibitors N-acetylcysteine and nitric oxide synthase inhibitor aminoguanidine increased the expression of CFTR. pimagedine 101-115 CF transmembrane conductance regulator Homo sapiens 144-148 19184353-6 2009 Histamine fluxes accounted for <25 % of hist-rad fluxes, but this percentage increased after blocking HMT (100 microM amodiaquin) or DAO (100 microM aminoguanidine). pimagedine 152-166 amine oxidase copper containing 1 Sus scrofa 136-139 18439771-0 2009 Effect of inhibition of synthesis of inducible nitric oxide synthase-derived nitric oxide by aminoguanidine on the in vitro maturation of oocyte-cumulus complexes of cattle. pimagedine 93-107 nitric oxide synthase 2 Bos taurus 37-68 26324992-8 2009 The ischemia-induced enteritis was significantly prevented by repeated treatment with aminoguanidine (a selective iNOS inhibitor), L-NAME (a nonselective NOS inhibitor), ampicillin, and aztreonam (a gram- negative bacterium antibiotic), but not vancomycin (a gram-positive bacterium antibiotic). pimagedine 86-100 nitric oxide synthase 2 Rattus norvegicus 114-118 19426682-4 2009 [(14)C]TEA uptake by hOCT2, but not hOCT1, was trans-stimulated by unlabeled guanidine, methylguanidine, creatinine, aminoguanidine and phenylguanidine. pimagedine 117-131 POU class 2 homeobox 2 Homo sapiens 21-26 19426682-6 2009 The uptake of aminoguanidine, a candidate for an anti-diabetic agent, was enhanced by hOCT2 with the Michaelis constant (K(m)) of 4.10+/-0.35mM. pimagedine 14-28 POU class 2 homeobox 2 Homo sapiens 86-91 19426682-8 2009 Aminoguanidine had little impact on the uptake of [(14)C]metformin by hOCT1, but inhibited that by hOCT2 with the IC(50) of 1.49+/-0.14mM. pimagedine 0-14 POU class 2 homeobox 2 Homo sapiens 99-104 19426682-10 2009 Among guanidine compounds, aminoguanidine was identified as a new superior substrate for hOCT2. pimagedine 27-41 POU class 2 homeobox 2 Homo sapiens 89-94 19429022-7 2009 Aminoguanidine reduced c-fos expression in the AP and NTS at 6h after CLP, but showed an opposite effect at 24h, with an increase in the AP, NTS, and also in the VLM. pimagedine 0-14 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-28 19236886-8 2009 The ischemia-induced enteritis was significantly prevented by repeated treatment with aminoguanidine (a selective iNOS inhibitor), L-NAME (a nonselective NOS inhibitor), ampicillin, and aztreonam (a gram-negative bacterium antibiotic), but not vancomycin (a gram-positive bacterium antibiotic). pimagedine 86-100 nitric oxide synthase 2 Rattus norvegicus 114-118 19426682-3 2009 Guanidine, creatinine and aminoguanidine more markedly inhibited the uptake of [(14)C]tetraethylammonium (TEA) by hOCT2 than by hOCT1. pimagedine 26-40 POU class 2 homeobox 2 Homo sapiens 114-119 19426682-3 2009 Guanidine, creatinine and aminoguanidine more markedly inhibited the uptake of [(14)C]tetraethylammonium (TEA) by hOCT2 than by hOCT1. pimagedine 26-40 solute carrier family 22 member 1 Homo sapiens 128-133 18439771-1 2009 The aim of the present study was to investigate the effects of inhibition of the enzyme inducible nitric oxide synthase (iNOS) by aminoguanidine (AG) on the in vitro maturation of oocyte-cumulus cell complex(es) (COC) of cattle. pimagedine 130-144 nitric oxide synthase 2 Bos taurus 88-119 18439771-1 2009 The aim of the present study was to investigate the effects of inhibition of the enzyme inducible nitric oxide synthase (iNOS) by aminoguanidine (AG) on the in vitro maturation of oocyte-cumulus cell complex(es) (COC) of cattle. pimagedine 130-144 nitric oxide synthase 2 Bos taurus 121-125 19023275-9 2009 Treatment with 17beta-estradiol (E(2)), tempol, or aminoguanidine for 6 weeks prevented Ovx-induced blood pressure elevation and apparently reversed the MMPs changes. pimagedine 51-65 matrix metallopeptidase 2 Rattus norvegicus 153-157 19110400-0 2009 The role of RAGE in aminoguanidine-induced suppression of venous intimal hyperplasia in diabetic rats. pimagedine 20-34 advanced glycosylation end product-specific receptor Rattus norvegicus 12-16 19110400-2 2009 In this study, we tested the hypothesis that the suppressive effect of aminoguanidine on intimal hyperplasia is mediated by downregulated expression of advanced glycation end products (AGE) and its receptor (RAGE) in streptozotocin-induced diabetes. pimagedine 71-85 advanced glycosylation end product-specific receptor Rattus norvegicus 208-212 19110400-9 2009 In diabetic rats treated with aminoguanidine, serum AGE level NF-kappaB p65 expression, the ratio of intima to media area, and the percentage of PCNA-positive cells in the vein graft were all significantly decreased. pimagedine 30-44 synaptotagmin 1 Rattus norvegicus 72-75 19110400-9 2009 In diabetic rats treated with aminoguanidine, serum AGE level NF-kappaB p65 expression, the ratio of intima to media area, and the percentage of PCNA-positive cells in the vein graft were all significantly decreased. pimagedine 30-44 proliferating cell nuclear antigen Rattus norvegicus 145-149 18719059-3 2009 METHODS: To examine the role of increased NO in COPD, we administered a relatively selective iNOS inhibitor, aminoguanidine, by nebulization in a double-blind, placebo-controlled study in COPD patients, healthy smokers, and healthy nonsmoking subjects. pimagedine 109-123 nitric oxide synthase 2 Homo sapiens 93-97 19010435-4 2009 The inducible NOS (iNOS) inhibitor aminoguanidine (20 mg/kg/day in the drinking water) also significantly reduced the eosinophil number in BALF. pimagedine 35-49 nitric oxide synthase 2, inducible Mus musculus 19-23 19010435-7 2009 The pulmonary iNOS activity was reduced by acute L-NAME (or aminoguanidine), but unaffected by 3-week L-NAME treatment. pimagedine 60-74 nitric oxide synthase 2, inducible Mus musculus 14-18 18927317-4 2008 GXM also induced macrophage apoptosis after 48 h of culture, with this phenomenon being prevented by the iNOS inhibitor, aminoguanidine. pimagedine 121-135 nitric oxide synthase 2 Rattus norvegicus 105-109 19012752-7 2009 The inhibitory effect of MGO on the gp130/STAT3 signaling was prevented by the pre-treatment with an advanced glycation endproduct scavenger aminoguanidine. pimagedine 141-155 interleukin 6 cytokine family signal transducer Homo sapiens 36-41 19012752-7 2009 The inhibitory effect of MGO on the gp130/STAT3 signaling was prevented by the pre-treatment with an advanced glycation endproduct scavenger aminoguanidine. pimagedine 141-155 signal transducer and activator of transcription 3 Homo sapiens 42-47 19192069-6 2008 NO synthase (NOS) activity was inhibited following a 20% BSA full-thickness burn by injection of non-specific NOS inhibitor, nitro-L-arginine methyl ester or inducible NOS (iNOS) inhibitors, L-N6-(1-iminoethyl) lysine, and aminoguanidine. pimagedine 223-237 nitric oxide synthase 1, neuronal Mus musculus 0-11 18706498-6 2008 Superoxide production paralleled the increase in iNOS expression, and inhibition of either iNOS (aminoguanidine or iminopiperdine) or superoxide (apocynin) significantly reduced cell death. pimagedine 97-111 nitric oxide synthase 2, inducible Mus musculus 91-95 18664363-8 2008 The induced NO, iNOS mRNA, and protein were all inhibited by the iNOS selective inhibitor, aminoguanidine (AG). pimagedine 91-105 nitric oxide synthase 2 Homo sapiens 16-20 18664363-8 2008 The induced NO, iNOS mRNA, and protein were all inhibited by the iNOS selective inhibitor, aminoguanidine (AG). pimagedine 91-105 nitric oxide synthase 2 Homo sapiens 65-69 18782627-4 2008 Pretreatment of aminoguanidine (an inhibitor of inducible nitric oxide synthase (iNOS), 10 microM) and vitamin C (an antioxidant agent, 100 microM) for 2h, reduced significantly the Ox-LDL-induced increase of NO and O2*-, and vitamin C completely inhibited increase of intracellular NO and O2*-. pimagedine 16-30 nitric oxide synthase 2 Homo sapiens 48-79 18782627-4 2008 Pretreatment of aminoguanidine (an inhibitor of inducible nitric oxide synthase (iNOS), 10 microM) and vitamin C (an antioxidant agent, 100 microM) for 2h, reduced significantly the Ox-LDL-induced increase of NO and O2*-, and vitamin C completely inhibited increase of intracellular NO and O2*-. pimagedine 16-30 nitric oxide synthase 2 Homo sapiens 81-85 18564400-4 2008 RESULTS: Compared with controls, GP91(PHOX) KO mice developed significantly (p < 0.0001) higher-titered immunoglobulin G (IgG) donor antibodies by two transfusions, and this immune response could be inhibited by treating the recipient mice with aminoguanidine, a relatively selective inhibitor of inducible nitric oxide synthase. pimagedine 248-262 paired Ig-like receptor B Mus musculus 33-37 18639532-5 2008 Treatment with aminoguanidine (iNOS inhibitor ), resulted in down-regulation of the iNOS expression, attenuation of the surge of nitric oxide (NO) in cerebral cortex and reversal of retrograde memory impairment due to hypoxia. pimagedine 15-29 nitric oxide synthase 2 Homo sapiens 31-35 18639532-5 2008 Treatment with aminoguanidine (iNOS inhibitor ), resulted in down-regulation of the iNOS expression, attenuation of the surge of nitric oxide (NO) in cerebral cortex and reversal of retrograde memory impairment due to hypoxia. pimagedine 15-29 nitric oxide synthase 2 Homo sapiens 84-88 18222473-5 2008 The aim of this study on a LPS induced HIR model was to investigate the effect of aminoguanidine (AG) administration on hepatic tissue iNOS expression and lipid peroxidation when given before or after LPS. pimagedine 82-96 nitric oxide synthase 2 Homo sapiens 135-139 18483403-9 2008 AGE formation and hypoxia markers (plasminogen activator inhibitor 1 and Bnip3) were increased in MRA from diabetic mice and normalized with Aminoguanidine. pimagedine 141-155 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 35-68 18483403-9 2008 AGE formation and hypoxia markers (plasminogen activator inhibitor 1 and Bnip3) were increased in MRA from diabetic mice and normalized with Aminoguanidine. pimagedine 141-155 BCL2/adenovirus E1B interacting protein 3 Mus musculus 73-78 18790185-0 2008 Inducible nitric oxide synthase expressions in different lung injury models and the protective effect of aminoguanidine. pimagedine 105-119 nitric oxide synthase 2 Homo sapiens 0-31 18790185-2 2008 The protective effect of an iNOS inhibitor, aminoguanidine, was evaluated in these 2 injury models. pimagedine 44-58 nitric oxide synthase 2 Homo sapiens 28-32 18790185-10 2008 The iNOS inhibitor aminoguanidine (20 mg/kg) significantly attenuated the lung injury induced by these challenges. pimagedine 19-33 nitric oxide synthase 2 Homo sapiens 4-8 18790185-12 2008 Administration of aminoguanidine can significantly attenuate the injury, suggesting that iNOS expression may play a critical role in the lung injury induced in these 2 models. pimagedine 18-32 nitric oxide synthase 2 Homo sapiens 89-93 18579559-5 2008 Suppression of iNOS signaling by aminoguanidine led to decreased HCC growth and NF-kB and RAS/ERK expression and increased apoptosis both in vivo and in vitro. pimagedine 33-47 nitric oxide synthase 2 Homo sapiens 15-19 18579559-5 2008 Suppression of iNOS signaling by aminoguanidine led to decreased HCC growth and NF-kB and RAS/ERK expression and increased apoptosis both in vivo and in vitro. pimagedine 33-47 mitogen-activated protein kinase 1 Homo sapiens 94-97 18625332-7 2008 RAW264.7 macrophages treated with iNOS inhibitor Aminoguanidine reverts the attenuation in arginase-blocked condition. pimagedine 49-63 nitric oxide synthase 2, inducible Mus musculus 34-38 18495358-7 2008 Aminoguanidine, an iNOS inhibitor, attenuated the LPS plus IFNgamma-induced glutamate release and decrease of microglial viability. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 19-23 18397269-6 2008 The protective activity of PAF was abrogated by pretreatment with the iNOS inhibitor, aminoguanidine, and in the iNOS(-/-) mice. pimagedine 86-100 patchy fur Mus musculus 27-30 18397269-8 2008 These effects of PAF were attenuated in the aminoguanidine-treated mice and the iNOS(-/-) mice. pimagedine 44-58 patchy fur Mus musculus 17-20 18495358-7 2008 Aminoguanidine, an iNOS inhibitor, attenuated the LPS plus IFNgamma-induced glutamate release and decrease of microglial viability. pimagedine 0-14 interferon gamma Mus musculus 59-67 18555096-3 2008 The aim of this study was to evaluate CYP isoenzyme activity changes in vivo and to examine histopathologic aspects during inhibition of iNOS after treatment with aminoguanidine (AG) using OLT in the rat. pimagedine 163-177 nitric oxide synthase 2 Rattus norvegicus 137-141 18562574-3 2008 Volunteers received 2 ng/kg Escherichia coli endotoxin in the absence (n = 7) or presence (n = 7) of the selective iNOS inhibitor aminoguanidine (bolus 5 mM followed by a continuous infusion of 1.5 mmol/h). pimagedine 130-144 nitric oxide synthase 2 Homo sapiens 115-119 18562574-7 2008 Aminoguanidine-treated subjects also developed tolerance to TLR-4 stimulation. pimagedine 0-14 toll like receptor 4 Homo sapiens 60-65 17997414-5 2008 We examined the effects of co-administration of arginine and aminoguanidine, a selective iNOS inhibitor, on sepsis, using rat models. pimagedine 61-75 nitric oxide synthase 2 Rattus norvegicus 89-93 17997414-9 2008 RESULTS: A combination of arginine and aminoguanidine recovered the plasma level of arginine at 6 h post-CLP, decreased expression of HO-1 in liver and lung at 24 h post-CLP, decreased urinary excretion of epinephrine, norepinephrine, dopamine, and 17-hydroxycorticosteroid in the first 24 h post-CLP, and increased 7-d survival. pimagedine 39-53 heme oxygenase 1 Rattus norvegicus 134-138 18437350-4 2008 METHODS: Inhibition of ApoA-I glycation was assessed by incubating aminoguanidine, pyridoxamine, metformin and alagebrium with mixtures of methylglyoxal and discoidal reconstituted HDL (rHDL) containing phosphatidylcholine and ApoA-I, ([A-I]rHDL). pimagedine 67-81 apolipoprotein A1 Homo sapiens 23-29 18437350-7 2008 RESULTS: Aminoguanidine, pyridoxamine, metformin and alagebrium all decreased the methylglyoxal-mediated glycation of the ApoA-I in discoidal rHDL and conserved the ability of the particles to act as substrates for LCAT. pimagedine 9-23 apolipoprotein A1 Homo sapiens 122-128 18437350-7 2008 RESULTS: Aminoguanidine, pyridoxamine, metformin and alagebrium all decreased the methylglyoxal-mediated glycation of the ApoA-I in discoidal rHDL and conserved the ability of the particles to act as substrates for LCAT. pimagedine 9-23 lecithin-cholesterol acyltransferase Homo sapiens 215-219 18622048-11 2008 Likewise, the expression of VEGF was also up-regulated in the colon following DSS treatment, and this response was suppressed by both L-NAME and aminoguanidine. pimagedine 145-159 vascular endothelial growth factor A Rattus norvegicus 28-32 18478477-1 2008 OBJECTIVE: To investigate the effect of a selective inducible nitric oxide synthase(iNOS) inhibitor, aminoguanidine (AG), on the proliferation and apoptosis of human colorectal cancer (CRC) Lovo cell line, and explore its possible mechanism. pimagedine 101-115 nitric oxide synthase 2 Homo sapiens 84-88 17970762-7 2008 Furthermore, treatment of activated macrophages with the iNOS inhibitor, aminoguanidine, inhibited clearance of B. mallei from infected monolayers. pimagedine 73-87 nitric oxide synthase 2, inducible Mus musculus 57-61 18313662-4 2008 Wistar Hannover rats were injected intraperitoneally with 5 mg/kg body weight lipopolysaccharide (LPS) or with both LPS and the iNOS inhibitor, aminoguanidine. pimagedine 144-158 nitric oxide synthase 2 Rattus norvegicus 128-132 18313662-9 2008 Co-administration of aminoguanidine attenuated the down-regulation of both Oct1 and Oct2 protein expression and reversed the decrease in rhodamine 123 clearance (P<0.001). pimagedine 21-35 solute carrier family 22 member 1 Rattus norvegicus 75-79 18313662-9 2008 Co-administration of aminoguanidine attenuated the down-regulation of both Oct1 and Oct2 protein expression and reversed the decrease in rhodamine 123 clearance (P<0.001). pimagedine 21-35 solute carrier family 22 member 2 Rattus norvegicus 84-88 18281381-9 2008 Aminoguanidine prevented the increase in exNO and the fall in MAP caused by LPS in Mkp-1(-/-) mice, without significantly affecting MAP or exNO in wild-type mice. pimagedine 0-14 dual specificity phosphatase 1 Mus musculus 83-88 18248896-4 2008 Here we show that intra-hippocampal injections of the iNOS inhibitor aminoguanidine during chronic unexpected mild stress (CUMS) suppressed CUMS-induced depression-like behavioral changes, including a reduction in sucrose preference, body weight, locomotor activity, rearing and grooming in open field test, and increased duration of immobility in forced swimming test. pimagedine 69-83 nitric oxide synthase 2 Homo sapiens 54-58 17971026-11 2008 Further, diabetic rats showed a significant reduction in duodenal nNOS expression by mRNA, protein and immunocytochemistry, an effect that was prevented by aminoguanidine. pimagedine 156-170 nitric oxide synthase 1 Rattus norvegicus 66-70 18242889-8 2008 However, aminoguanidine (AG), a selective inhibitor of inducible nitric oxide synthase (iNOS), and pentoxifylline (PTX), an inhibitor of tumor necrosis factor alpha (TNF-alpha) synthesis, had no effect on LPS-induced upregulation of HO-1 in fetal liver. pimagedine 9-23 heme oxygenase 1 Mus musculus 233-237 18093296-6 2007 Additionally, DBA/2J mice were treated with the NOS2 inhibitor aminoguanidine and the disease compared to untreated mice. pimagedine 63-77 nitric oxide synthase 2, inducible Mus musculus 48-52 17621264-4 2008 Intracellular NO was detected in the bystander cells, and additional TGF-beta1 was detected in the medium from irradiated T98G cells, but it was diminished by aminoguanidine. pimagedine 159-173 transforming growth factor beta 1 Homo sapiens 69-78 18281904-4 2008 However, pretreatment with taurine prevented the hearing damage with decreased iNOS expression, similar to the effect of aminoguanidine, a selective inhibitor of iNOS. pimagedine 121-135 nitric oxide synthase, inducible Cavia porcellus 162-166 17950015-5 2008 Pregnant rats were pretreated with the iNOS inhibitor aminoguanidine (50mg/rat per day; given from day 13 of gestation up to delivery) before exposure to LPS (7mug/kg, given at day 17 of gestation). pimagedine 54-68 nitric oxide synthase 2 Rattus norvegicus 39-43 18209962-5 2008 RESULTS: Aminoguanidine reduced the gastric damage induced by indomethacin at 20 mg.kg(-1), but increased gastric MPO activity. pimagedine 9-23 myeloperoxidase Rattus norvegicus 114-117 18023101-11 2007 CONCLUSION: Selective iNOS inhibitor, aminoguanidine as a free radical, has a protective effect on pancreas transplantation in rats by inhibiting NO and reducing its toxicity. pimagedine 38-52 nitric oxide synthase 2 Rattus norvegicus 22-26 17786558-5 2007 Concomitant administration of SP600125, a selective JNK inhibitor, or aminoguanidine (AG), a selected inducible nitric oxide synthase (iNOS) inhibitor, effectively diminished BCL-2 phosphorylation, suppressed cytochrome c release from mitochondria and caspase activation, and significantly prevented ctx-induced muscle cell apoptosis. pimagedine 70-84 nitric oxide synthase 2, inducible Mus musculus 102-133 18001059-3 2007 Rabbit liver AOX is capable of reducing IMI to both its nitrosoguanidine (IMI-NO) and aminoguanidine (IMI-NH2) derivatives; however, when IMI-NO is used as a substrate, less than stoichiometric amounts of IMI-NH2 are detected while IMI-NO is completely consumed. pimagedine 86-100 acyl-CoA oxidase 1 Homo sapiens 13-16 18198303-7 2007 To analyze the role of inducible nitric oxide synthase (iNOS), the iNOS inhibitor aminoguanidine was added to the chamber. pimagedine 82-96 nitric oxide synthase 2, inducible Mus musculus 67-71 17968175-11 2007 Treatment with the selective iNOS inhibitor aminoguanidine prevented T/HS lymph-induced lung injury. pimagedine 44-58 nitric oxide synthase 2, inducible Mus musculus 29-33 17784902-12 2007 Moreover, iNOS-derived NO possibly produces unfavourable effects, which are counteracted by aminoguanidine. pimagedine 92-106 nitric oxide synthase 2 Canis lupus familiaris 10-14 17786558-5 2007 Concomitant administration of SP600125, a selective JNK inhibitor, or aminoguanidine (AG), a selected inducible nitric oxide synthase (iNOS) inhibitor, effectively diminished BCL-2 phosphorylation, suppressed cytochrome c release from mitochondria and caspase activation, and significantly prevented ctx-induced muscle cell apoptosis. pimagedine 70-84 nitric oxide synthase 2, inducible Mus musculus 135-139 17786558-5 2007 Concomitant administration of SP600125, a selective JNK inhibitor, or aminoguanidine (AG), a selected inducible nitric oxide synthase (iNOS) inhibitor, effectively diminished BCL-2 phosphorylation, suppressed cytochrome c release from mitochondria and caspase activation, and significantly prevented ctx-induced muscle cell apoptosis. pimagedine 70-84 B cell leukemia/lymphoma 2 Mus musculus 175-180 17504976-6 2007 Arginine and aminoguanidine, used as carbonyl scavengers, reversed the inhibitory effect and the formation of AGE adducts on PDGFRbeta. pimagedine 13-27 platelet derived growth factor receptor, beta polypeptide Mus musculus 125-134 17943250-9 2007 Combination of rofecoxib (10 mg/kg) and aminoguanidine hydrochloride (30 mg/kg) has maximal protective effect on colonic injury induced by TNBS enema which is probably, via mechanism of local inhibition of iNOS and COX-2 activity in colonic mucosa and support the idea that simultaneous inhibition of iNOS and COX-2 inhibitors have a promising potential in the treatment of colitis. pimagedine 40-68 nitric oxide synthase 2 Rattus norvegicus 206-210 17880178-10 2007 The glycation/glycoxidation inhibitor aminoguanidine and the glucuronidation inhibitor borneol significantly decreased clofibric-acid-mediated DNA damage in UGT2B7 transfected cells by 73.5 and 94.8%, respectively. pimagedine 38-52 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 157-163 17943250-9 2007 Combination of rofecoxib (10 mg/kg) and aminoguanidine hydrochloride (30 mg/kg) has maximal protective effect on colonic injury induced by TNBS enema which is probably, via mechanism of local inhibition of iNOS and COX-2 activity in colonic mucosa and support the idea that simultaneous inhibition of iNOS and COX-2 inhibitors have a promising potential in the treatment of colitis. pimagedine 40-68 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 215-220 17943250-9 2007 Combination of rofecoxib (10 mg/kg) and aminoguanidine hydrochloride (30 mg/kg) has maximal protective effect on colonic injury induced by TNBS enema which is probably, via mechanism of local inhibition of iNOS and COX-2 activity in colonic mucosa and support the idea that simultaneous inhibition of iNOS and COX-2 inhibitors have a promising potential in the treatment of colitis. pimagedine 40-68 nitric oxide synthase 2 Rattus norvegicus 301-305 17943250-9 2007 Combination of rofecoxib (10 mg/kg) and aminoguanidine hydrochloride (30 mg/kg) has maximal protective effect on colonic injury induced by TNBS enema which is probably, via mechanism of local inhibition of iNOS and COX-2 activity in colonic mucosa and support the idea that simultaneous inhibition of iNOS and COX-2 inhibitors have a promising potential in the treatment of colitis. pimagedine 40-68 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 310-315 17920637-7 2007 Aminoguanidine, an inhibitor of iNOS, significantly suppressed the damage, yet the efficacy differed in normal and arthritic rats, depending on the dose schedule; the effect of post-administration (6 h after) was greater than that of pre-administration (0.5 h before) in normal rats, whereas that of post-administration was less than that of pre-administration in arthritic rats. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 32-36 17447015-11 2007 A selective iNOS inhibitor, aminoguanidine, suppressed TG-stimulated NO production and ALT leakage from hepatocytes after 24-48 h. Our data suggest that the extent of the [Ca2+]i increase and the modulation of NO production due to TG treatment contribute to hepatocyte apoptotic and/or necrotic events. pimagedine 28-42 nitric oxide synthase 2 Rattus norvegicus 12-16 18396755-1 2007 OBJECTIVE: To observe the influence of aminoguanidine on cardiac troponin (cTnI) and nitric oxide (NO) levels in serum and myocardium in severely scalded rats. pimagedine 39-53 troponin I3, cardiac type Rattus norvegicus 57-73 18396755-1 2007 OBJECTIVE: To observe the influence of aminoguanidine on cardiac troponin (cTnI) and nitric oxide (NO) levels in serum and myocardium in severely scalded rats. pimagedine 39-53 troponin I3, cardiac type Rattus norvegicus 75-79 17663721-5 2007 This MG-induced activation of Chk1 and Chk2 were inhibited by either aminoguanidine (AG), an inhibitor of production of advanced glycation end products (AGEs) or N-acetyl-l-cysteine (NAC), an anti-oxidant in dose dependent manners, indicating that oxidative stress via AGEs is involved critically in the activation of Chk1 and Chk2 by MG. pimagedine 69-83 checkpoint kinase 1 Homo sapiens 30-34 17596537-0 2007 Evidence for in vivo scavenging by aminoguanidine of formaldehyde produced via semicarbazide-sensitive amine oxidase-mediated deamination. pimagedine 35-49 amine oxidase copper containing 2 Homo sapiens 79-116 17596537-1 2007 Aminoguanidine (AG) is capable of preventing advanced protein glycation and inhibiting the activity of enzymes with carbonyl groups as cofactors, such as nitric-oxide synthase (NOS) and semicarbazide-sensitive amine oxidase (SSAO). pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 154-175 17596537-1 2007 Aminoguanidine (AG) is capable of preventing advanced protein glycation and inhibiting the activity of enzymes with carbonyl groups as cofactors, such as nitric-oxide synthase (NOS) and semicarbazide-sensitive amine oxidase (SSAO). pimagedine 0-14 amine oxidase copper containing 2 Homo sapiens 186-223 17596537-1 2007 Aminoguanidine (AG) is capable of preventing advanced protein glycation and inhibiting the activity of enzymes with carbonyl groups as cofactors, such as nitric-oxide synthase (NOS) and semicarbazide-sensitive amine oxidase (SSAO). pimagedine 0-14 amine oxidase copper containing 2 Homo sapiens 225-229 17626897-7 2007 The glucose transporter inhibitor cytochalasin B, the aldose reductase inhibitor alrestatin, and the advanced glycation end product formation inhibitor aminoguanidine attenuated HG-induced Ang II generation. pimagedine 152-166 angiotensinogen Rattus norvegicus 189-195 17706723-8 2007 On the other hand, aminoguanidine (AG) pre-treatment blocked the rise of inhibition of NO generation and decreased VEGF expression. pimagedine 19-33 vascular endothelial growth factor A Rattus norvegicus 115-119 17293848-4 2007 We found that the tolerance is blocked by the iNOS inhibitor aminoguanidine, is not observed in iNOS-null mice, and is rescued by the NO donor DTPA NONOate. pimagedine 61-75 nitric oxide synthase 2, inducible Mus musculus 46-50 17663721-5 2007 This MG-induced activation of Chk1 and Chk2 were inhibited by either aminoguanidine (AG), an inhibitor of production of advanced glycation end products (AGEs) or N-acetyl-l-cysteine (NAC), an anti-oxidant in dose dependent manners, indicating that oxidative stress via AGEs is involved critically in the activation of Chk1 and Chk2 by MG. pimagedine 69-83 checkpoint kinase 2 Homo sapiens 39-43 17663721-5 2007 This MG-induced activation of Chk1 and Chk2 were inhibited by either aminoguanidine (AG), an inhibitor of production of advanced glycation end products (AGEs) or N-acetyl-l-cysteine (NAC), an anti-oxidant in dose dependent manners, indicating that oxidative stress via AGEs is involved critically in the activation of Chk1 and Chk2 by MG. pimagedine 69-83 checkpoint kinase 1 Homo sapiens 318-322 17663721-5 2007 This MG-induced activation of Chk1 and Chk2 were inhibited by either aminoguanidine (AG), an inhibitor of production of advanced glycation end products (AGEs) or N-acetyl-l-cysteine (NAC), an anti-oxidant in dose dependent manners, indicating that oxidative stress via AGEs is involved critically in the activation of Chk1 and Chk2 by MG. pimagedine 69-83 checkpoint kinase 2 Homo sapiens 327-331 17554258-7 2007 MMP-7 expression was normalized by both aminoguanidine, an inhibitor of glycation product formation, or by a neutralizing anti-transforming growth factor-beta (TGF-beta) antibody. pimagedine 40-54 matrix metallopeptidase 7 Homo sapiens 0-5 17554258-8 2007 In streptozotocin-induced diabetic rats, the diminution in MMP-7 expression and excessive fibronectin accumulation were attenuated by aminoguanidine. pimagedine 134-148 matrix metallopeptidase 7 Rattus norvegicus 59-64 17554258-8 2007 In streptozotocin-induced diabetic rats, the diminution in MMP-7 expression and excessive fibronectin accumulation were attenuated by aminoguanidine. pimagedine 134-148 fibronectin 1 Rattus norvegicus 90-101 17196628-6 2007 NM was injected intratracheally and was treated with the selective inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (AG) (intraperitoneal) or the peroxynitrite scavenger ebselen (intragastric). pimagedine 116-130 nitric oxide synthase 2 Rattus norvegicus 100-104 17223208-7 2007 administration of aminoguanidine, an iNOS blocker, on plasma ANP levels and MAP during experimental endotoxemic shock. pimagedine 18-32 natriuretic peptide A Rattus norvegicus 61-64 16920373-1 2007 OBJECTIVES: The objective of this study was to examine the effects of rofecoxib, meloxicam, both cyclooxygenase-2 (COX-2) inhibitors and aminoguanidine hydrochloride, an inducible nitric oxide synthase (iNOS) inhibitor and their combinations in neuropathic pain in rats. pimagedine 137-165 nitric oxide synthase 2 Rattus norvegicus 203-207 17548204-0 2007 Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats. pimagedine 25-39 amine oxidase, copper containing 3 Rattus norvegicus 68-105 17548204-1 2007 Beneficial effects of aminoguanidine (AG) on diabetic vascular complications result from prevention of protein glycation, inhibition of inductible NO synthase, and inhibition of vascular semicarbazide-sensitive amine oxidase (SSAO). pimagedine 22-36 amine oxidase, copper containing 3 Rattus norvegicus 187-224 17548204-1 2007 Beneficial effects of aminoguanidine (AG) on diabetic vascular complications result from prevention of protein glycation, inhibition of inductible NO synthase, and inhibition of vascular semicarbazide-sensitive amine oxidase (SSAO). pimagedine 22-36 amine oxidase, copper containing 3 Rattus norvegicus 226-230 17241792-6 2007 Administration of aminoguanidine (AG), a specific iNOS inhibitor, abolished macrophage phagocytic activity and total plasma nitrite levels in the LPS and LPS+L-arginine groups. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 50-54 17637181-11 2007 While aminoguanidine and ascorbic acid also attenuated the LPS-induced increase in p38 MAPK, iNOS and COX-2 proteins in the aorta and lymphocytes, trazodone and yohimbine inhibited only the increase in p38 MAPK, iNOS and COX-2 proteins in lymphocytes. pimagedine 6-20 nitric oxide synthase 2 Rattus norvegicus 93-97 17637181-11 2007 While aminoguanidine and ascorbic acid also attenuated the LPS-induced increase in p38 MAPK, iNOS and COX-2 proteins in the aorta and lymphocytes, trazodone and yohimbine inhibited only the increase in p38 MAPK, iNOS and COX-2 proteins in lymphocytes. pimagedine 6-20 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 102-107 17637181-11 2007 While aminoguanidine and ascorbic acid also attenuated the LPS-induced increase in p38 MAPK, iNOS and COX-2 proteins in the aorta and lymphocytes, trazodone and yohimbine inhibited only the increase in p38 MAPK, iNOS and COX-2 proteins in lymphocytes. pimagedine 6-20 nitric oxide synthase 2 Rattus norvegicus 212-216 17637181-11 2007 While aminoguanidine and ascorbic acid also attenuated the LPS-induced increase in p38 MAPK, iNOS and COX-2 proteins in the aorta and lymphocytes, trazodone and yohimbine inhibited only the increase in p38 MAPK, iNOS and COX-2 proteins in lymphocytes. pimagedine 6-20 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 221-226 16987713-1 2007 The aim of this study was to investigate the ability of aminoguanidine (AG) to prevent diabetes-induced changes in nitric oxide synthase- (nNOS), vasoactive intestinal polypeptide- (VIP) and noradrenaline- (NA) containing nerves of the rat ileum using immunohistochemical and biochemical techniques. pimagedine 56-70 nitric oxide synthase 1 Rattus norvegicus 139-143 17348040-4 2007 Interestingly, the expressions of HSP60 and HSP10 were further upregulated by the administration of aminoguanidine (AG), an inhibitor of the inducible nitric oxide synthase (iNOS), which is known to reduce ischemic damage in an animal model after MCAO. pimagedine 100-114 heat shock protein family D (Hsp60) member 1 Homo sapiens 34-39 17348040-4 2007 Interestingly, the expressions of HSP60 and HSP10 were further upregulated by the administration of aminoguanidine (AG), an inhibitor of the inducible nitric oxide synthase (iNOS), which is known to reduce ischemic damage in an animal model after MCAO. pimagedine 100-114 heat shock protein family E (Hsp10) member 1 Homo sapiens 44-49 17348040-4 2007 Interestingly, the expressions of HSP60 and HSP10 were further upregulated by the administration of aminoguanidine (AG), an inhibitor of the inducible nitric oxide synthase (iNOS), which is known to reduce ischemic damage in an animal model after MCAO. pimagedine 100-114 nitric oxide synthase 2 Homo sapiens 141-172 17348040-4 2007 Interestingly, the expressions of HSP60 and HSP10 were further upregulated by the administration of aminoguanidine (AG), an inhibitor of the inducible nitric oxide synthase (iNOS), which is known to reduce ischemic damage in an animal model after MCAO. pimagedine 100-114 nitric oxide synthase 2 Homo sapiens 174-178 17333105-8 2007 Treatment with aminoguanidine inhibited Cyr61 and Ctgf expression in diabetic rats, with reductions of 31 and 36%, respectively, compared with untreated animals. pimagedine 15-29 cellular communication network factor 1 Rattus norvegicus 40-45 17333105-8 2007 Treatment with aminoguanidine inhibited Cyr61 and Ctgf expression in diabetic rats, with reductions of 31 and 36%, respectively, compared with untreated animals. pimagedine 15-29 cellular communication network factor 2 Rattus norvegicus 50-54 17333105-9 2007 Western blotting showed a twofold increase in CTGF production, which was prevented by aminoguanidine treatment. pimagedine 86-100 cellular communication network factor 2 Rattus norvegicus 46-50 17283224-8 2007 Furthermore, previous application of the inducible NOS (iNOS) inhibitor, aminoguanidine, but not the neuronal NOS inhibitor, 7-nitroindazole, attenuated the cardiovascular effect of alpha-MSH. pimagedine 73-87 nitric oxide synthase 2 Rattus norvegicus 41-54 17283224-8 2007 Furthermore, previous application of the inducible NOS (iNOS) inhibitor, aminoguanidine, but not the neuronal NOS inhibitor, 7-nitroindazole, attenuated the cardiovascular effect of alpha-MSH. pimagedine 73-87 nitric oxide synthase 2 Rattus norvegicus 56-60 17283224-8 2007 Furthermore, previous application of the inducible NOS (iNOS) inhibitor, aminoguanidine, but not the neuronal NOS inhibitor, 7-nitroindazole, attenuated the cardiovascular effect of alpha-MSH. pimagedine 73-87 proopiomelanocortin Rattus norvegicus 182-191 17285300-3 2007 Wistar-Hannover rats were injected with lipopolysaccharide (LPS(+)) alone or in combination with the iNOS inhibitor, aminoguanidine. pimagedine 117-131 nitric oxide synthase 2 Rattus norvegicus 101-105 17285300-7 2007 Coadministration with aminoguanidine resulted in an attenuation of iNOS induction and reduction of renal damage. pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 67-71 17094870-2 2007 Inhibition of nitric oxide synthase 2 (NOS2) by aminoguanidine (AG) prevented hyporesponsiveness to inhaled NO. pimagedine 48-62 nitric oxide synthase 2 Rattus norvegicus 14-37 17094870-2 2007 Inhibition of nitric oxide synthase 2 (NOS2) by aminoguanidine (AG) prevented hyporesponsiveness to inhaled NO. pimagedine 48-62 nitric oxide synthase 2 Rattus norvegicus 39-43 16987713-1 2007 The aim of this study was to investigate the ability of aminoguanidine (AG) to prevent diabetes-induced changes in nitric oxide synthase- (nNOS), vasoactive intestinal polypeptide- (VIP) and noradrenaline- (NA) containing nerves of the rat ileum using immunohistochemical and biochemical techniques. pimagedine 56-70 vasoactive intestinal peptide Rattus norvegicus 146-180 16987713-1 2007 The aim of this study was to investigate the ability of aminoguanidine (AG) to prevent diabetes-induced changes in nitric oxide synthase- (nNOS), vasoactive intestinal polypeptide- (VIP) and noradrenaline- (NA) containing nerves of the rat ileum using immunohistochemical and biochemical techniques. pimagedine 56-70 vasoactive intestinal peptide Rattus norvegicus 182-185 17193882-3 2007 In addition, the left hind quarter was infused with aminoguanidine, an inhibitor of the inducible form of NO synthase (iNOS). pimagedine 52-66 nitric oxide synthase 2 Bos taurus 119-123 17460428-6 2007 The majority of this signal was eliminated by the inducible nitric oxide synthase (iNOS) specific inhibitor aminoguanidine injected inflamed retina was detected when compared with that of the non inflamed controls. pimagedine 108-122 nitric oxide synthase 2 Rattus norvegicus 50-81 17460428-6 2007 The majority of this signal was eliminated by the inducible nitric oxide synthase (iNOS) specific inhibitor aminoguanidine injected inflamed retina was detected when compared with that of the non inflamed controls. pimagedine 108-122 nitric oxide synthase 2 Rattus norvegicus 83-87 17077807-12 2007 Aminoguanidine (100 mg/kg/day; an iNOS antagonist) significantly increased proliferation in corticosterone-treated rats (40 mg/kg/day) but not in controls without additional corticosterone, confirming that iNOS plays a role in corticosterone-regulated neurogenesis. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 34-38 17077807-12 2007 Aminoguanidine (100 mg/kg/day; an iNOS antagonist) significantly increased proliferation in corticosterone-treated rats (40 mg/kg/day) but not in controls without additional corticosterone, confirming that iNOS plays a role in corticosterone-regulated neurogenesis. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 206-210 17334528-2 2007 Aminoguanidine (AG) is a selective iNOS inhibitor with reported inconsistent actions in sepsis. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 35-39 17173980-6 2007 Aminoguanidine pre-treatment prevented the increase in plasma nitrate levels and hypotension in the first 6 h. It also reduced AVP secretion and hypothalamic c-fos expression. pimagedine 0-14 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 158-163 17197555-17 2007 Aminoguanidine, a nonspecific inhibitor of iNOS, inhibited I/R-induced degeneration of both neuronal and vascular cells of the retina. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 43-47 16475165-10 2006 Moreover, treatment with the iNOS specific inhibitor aminoguanidine (AG) also enhanced Cl41 cells transformation induced by TPA. pimagedine 53-67 nitric oxide synthase 2, inducible Mus musculus 29-33 17056264-5 2007 Accordingly, neuronal survival rate in the co-cultures was recovered to control levels by treatment of the cultures with the iNOS inhibitor, aminoguanidine. pimagedine 141-155 nitric oxide synthase 2, inducible Mus musculus 125-129 17522764-7 2007 A dorsal air sac assay demonstrated that IFN-beta inhibited angiogenesis in mice inoculated with CT 26, but the effects disappeared with aminoguanidine, an inducible nitric oxide synthase inhibitor. pimagedine 137-151 interferon beta 1, fibroblast Mus musculus 41-49 17357539-1 2006 The roles of nitric oxide production and oxidative process were studied in mice infected with Toxocara canis and treated with aminoguanidine which is a specific inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 126-140 nitric oxide synthase 2, inducible Mus musculus 174-205 17357539-1 2006 The roles of nitric oxide production and oxidative process were studied in mice infected with Toxocara canis and treated with aminoguanidine which is a specific inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 126-140 nitric oxide synthase 2, inducible Mus musculus 207-211 17242472-6 2006 Since aminoguanidine caused a transient fall in T(b) below the baseline in rats exposed or not to open field and because this inhibitor suppressed stress-induced rise in locomotor activity, we concluded that nNOS expression inside the brain is critically involved in the rise in T(b) due to exposure to psychological stress. pimagedine 6-20 nitric oxide synthase 1 Rattus norvegicus 208-212 16890370-9 2006 HPC and aminoguanidine, an iNOS inhibitor, prevented OGD-induced Purkinje cell death/injury. pimagedine 8-22 nitric oxide synthase 2 Rattus norvegicus 27-31 16881050-7 2006 The LPS down-regulatory effect on TfR protein expression is abolished by the NADPH oxidase inhibitor diphenyliodonium (DPI) but is not affected by the free radical scavenger N-acetyl-L-cysteine (NAC) or the iNOS inhibitor aminoguanidine (AG). pimagedine 222-236 transferrin receptor Mus musculus 34-37 16730029-8 2006 Both L-NAME and aminoguanidine markedly aggravated gastric lesions induced by iodoacetamide treatment, with a further enhancement in MPO activity and lipid peroxidation. pimagedine 16-30 myeloperoxidase Rattus norvegicus 133-136 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. pimagedine 105-119 nitric oxide synthase 2 Homo sapiens 26-47 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. pimagedine 105-119 nitric oxide synthase 2 Homo sapiens 49-53 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. pimagedine 105-119 interferon regulatory factor 6 Homo sapiens 145-148 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. pimagedine 105-119 insulin like growth factor 1 Homo sapiens 182-187 16619262-3 2006 Here, roles of two inflammatory mediators, cyclo-oxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS), in the injury responses were analysed by examining their gene expression and effects of blocking their activities, respectively, with celecoxib and aminoguanidine during 2 days prior to and until 7 days after injury in a rat tibial growth plate injury model. pimagedine 261-275 nitric oxide synthase 2 Rattus norvegicus 106-110 16797727-9 2006 However, in monocyte-derived macrophages, with a higher NO production, aminoguanidine increased IDO activity, but the NOS substrate arginine decreased IDO activity. pimagedine 71-85 indoleamine 2,3-dioxygenase 1 Homo sapiens 96-99 16953666-6 2006 Moreover, both the calcium fluxes and the bystander effect were inhibited when the irradiated T98G cells were treated with aminoguanidine, an inhibitor of nitric oxide synthase (NOS), and when the irradiated AG01522 cells were treated with DMSO, a scavenger of reactive oxygen species (ROS), which indicates that NO and ROS were involved in the bystander responses generated from irradiated T98G and AG01522 cells, respectively. pimagedine 123-137 nitric oxide synthase 2 Homo sapiens 155-176 16980043-9 2006 The iNOS inhibitor aminoguanidine was also tested in this I/R model. pimagedine 19-33 nitric oxide synthase 2 Homo sapiens 4-8 16980043-13 2006 The iNOS inhibitor aminoguanidine (10 mg/kg) significantly attenuated the lung injury. pimagedine 19-33 nitric oxide synthase 2 Homo sapiens 4-8 16980043-15 2006 Administration of aminoguanidine significantly attenuated the injury, suggesting that iNOS expression may play a critical role in lung injury induced by I/R of the liver. pimagedine 18-32 nitric oxide synthase 2 Homo sapiens 86-90 16442319-5 2006 Inhibition of leptin secretion that had been induced by the IFN-gamma-LPS mixture was completely nullified by NOS inhibitors such as Nomega-monomethyl-L-arginine and aminoguanidine. pimagedine 166-180 interferon gamma Homo sapiens 60-69 17290789-3 2006 Aminoguanidine, being the selective iNOS inhibitor, antioxidant and the factor eliminating post-translational protein nitrozylation and oxidative modification, weaken the toxic effects of NO and positively modulates the pathological state caused by NO hyperproduction. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 36-40 16690710-6 2006 In N, and 1 and 3CH rats, the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine had no effect on baselines or increases in FVC evoked by acetylcholine. pimagedine 79-93 nitric oxide synthase 2 Rattus norvegicus 30-61 16690710-6 2006 In N, and 1 and 3CH rats, the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine had no effect on baselines or increases in FVC evoked by acetylcholine. pimagedine 79-93 nitric oxide synthase 2 Rattus norvegicus 63-67 16978515-0 2006 [Effects of selective iNOS inhibitor aminoguanidine on waveform of blood pressure in rat heat stroke]. pimagedine 37-51 nitric oxide synthase 2 Rattus norvegicus 22-26 16865093-11 2006 Aminoguanidine prevented the inhibitory effect of IL-2 on carrageenin-induced neutrophil migration, rolling and adhesion. pimagedine 0-14 interleukin 2 Mus musculus 50-54 16691532-15 2006 Animals receiving both L- NAME and aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) inhibitor (65 mg/Kg body weight/day, orally), showed significant decrease in the nitrite serum levels, sympathetic denervation and macrophage infiltration at day 7. pimagedine 35-49 nitric oxide synthase 2 Rattus norvegicus 59-90 16691532-15 2006 Animals receiving both L- NAME and aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) inhibitor (65 mg/Kg body weight/day, orally), showed significant decrease in the nitrite serum levels, sympathetic denervation and macrophage infiltration at day 7. pimagedine 35-49 nitric oxide synthase 2 Rattus norvegicus 92-96 16978515-6 2006 CONCLUSION: iNOS may contribute to heatstroke, and aminoguanidine can provide protective effects on heatstroke as a selective iNOS inhibitor. pimagedine 51-65 nitric oxide synthase 2 Rattus norvegicus 126-130 16730698-1 2006 The effect of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, on morphine-induced tolerance and dependence in mice was investigated in this study. pimagedine 14-28 nitric oxide synthase 2, inducible Mus musculus 33-64 17699297-4 2006 In addition, the effect of co-administration of the selective iNOS inhibitor aminoguanidine was evaluated. pimagedine 77-91 nitric oxide synthase 2 Homo sapiens 62-66 17699297-10 2006 Co-administration of aminoguanidine reduced the upregulation of iNOS mRNA, urinary NO metabolite, and GSTA1-1 excretion, indicating that upregulation of iNOS and subsequent NO production may be responsible for renal proximal tubule damage observed. pimagedine 21-35 nitric oxide synthase 2 Homo sapiens 64-68 17699297-10 2006 Co-administration of aminoguanidine reduced the upregulation of iNOS mRNA, urinary NO metabolite, and GSTA1-1 excretion, indicating that upregulation of iNOS and subsequent NO production may be responsible for renal proximal tubule damage observed. pimagedine 21-35 glutathione S-transferase alpha 1 Homo sapiens 102-109 17699297-10 2006 Co-administration of aminoguanidine reduced the upregulation of iNOS mRNA, urinary NO metabolite, and GSTA1-1 excretion, indicating that upregulation of iNOS and subsequent NO production may be responsible for renal proximal tubule damage observed. pimagedine 21-35 nitric oxide synthase 2 Homo sapiens 153-157 16730698-1 2006 The effect of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, on morphine-induced tolerance and dependence in mice was investigated in this study. pimagedine 14-28 nitric oxide synthase 2, inducible Mus musculus 66-70 16730698-12 2006 These results provide evidence that blockade of NO overproduction, the consequence of NMDA receptor activation, by aminoguanidine, via inhibition of iNOS, can attenuate the development of morphine tolerance and dependence. pimagedine 115-129 nitric oxide synthase 2, inducible Mus musculus 149-153 29435886-8 2006 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, showed anti-ulcerogenic effects similar to those oberved for curcumin. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 19-50 29435886-8 2006 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, showed anti-ulcerogenic effects similar to those oberved for curcumin. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 52-56 16469770-5 2006 Concomitant administration of aminoguanidine, a selective iNOS inhibitor, significantly prevented hormone deprivation-induced germ cell apoptosis. pimagedine 30-44 nitric oxide synthase 2 Homo sapiens 58-62 16555297-9 2006 Preincubation with the carbonyl scavenger aminoguanidine prevented tau dephosphorylation, indicating the specific effect of methylglyoxal. pimagedine 42-56 microtubule associated protein tau Homo sapiens 67-70 16786102-8 2006 While aminoguanidine (AG, iNOS inhibitor) increased the firing rate at the resting level from (11.5 +/- 5.1) spikes/s to (17.8 +/- 5.6), (22.5 +/- 6.3) and (29.1 +/- 6.4) spikes/s (P<0.05, n=8) at the current of 10, 20 and 40 nA in 8 barosensitive neurons, respectively. pimagedine 6-20 nitric oxide synthase 2 Rattus norvegicus 26-30 16866623-6 2006 Common NO synthase inhibitor pharmacotherapy with aminoguanidine and L-NAME completely abolished endostatin release from microglial cells, raising hopes of altering endostatin release in vivo. pimagedine 50-64 collagen type XVIII alpha 1 chain Homo sapiens 97-107 16866623-6 2006 Common NO synthase inhibitor pharmacotherapy with aminoguanidine and L-NAME completely abolished endostatin release from microglial cells, raising hopes of altering endostatin release in vivo. pimagedine 50-64 collagen type XVIII alpha 1 chain Homo sapiens 165-175 16680016-11 2006 RESULTS: Aminoguanidine treatment decreased LPS-induced macroscopic gastric injury as well as MMP-2 and MT1-MMP protein production while having no effect on TIMP-2 protein levels. pimagedine 9-23 matrix metallopeptidase 2 Rattus norvegicus 94-99 16650388-6 2006 Bilateral microdialysis of a selective iNOS antagonist, aminoguanidine (AGN; 1.0 microM), for 60 min into the RVLM attenuated increases in mean arterial pressure (MAP), heart rate (HR), and extracellular glutamate levels during a static muscle contraction. pimagedine 56-70 nitric oxide synthase 2 Homo sapiens 39-43 16650388-6 2006 Bilateral microdialysis of a selective iNOS antagonist, aminoguanidine (AGN; 1.0 microM), for 60 min into the RVLM attenuated increases in mean arterial pressure (MAP), heart rate (HR), and extracellular glutamate levels during a static muscle contraction. pimagedine 72-75 nitric oxide synthase 2 Homo sapiens 39-43 16504557-8 2006 Compared to N and S groups, in I/R mice selective iNOS inhibitor P-BIT significantly prevented motor, MPO and EB changes; putative iNOS inhibitor aminoguanidine significantly counteracted GIT delay but not neutrophil recruitment and the increase in vascular permeability; NOS inhibitor l-NAME and NO precursor l-arginine were scarcely or no effective. pimagedine 146-160 nitric oxide synthase 2, inducible Mus musculus 131-135 16504557-9 2006 Furthermore, in S mice aminoguanidine caused a significant increase of MPO activity reverted by H(1) histamine receptor antagonist pre-treatment. pimagedine 23-37 myeloperoxidase Mus musculus 71-74 16700724-6 2006 In normal stomach, VIP produced relaxation, which was reduced by VIP6-28, antagonist of VIP receptors, but was not modified by Nomega-nitro-L-arginine methyl ester (L-NAME), 1-H-oxodiazol-[1,2,4]-[4,3-a]quinoxaline-1-one (ODQ) or by N-(3-(aminomethyl)-benzyl)acetamidine (1400W) and aminoguanidine, inhibitors of iNOS. pimagedine 283-297 vasoactive intestinal polypeptide Mus musculus 19-22 16700724-7 2006 In contrast, in mdx stomach VIP responses were antagonized not only by VIP6-28, but also by L-NAME, ODQ, 1400W or aminoguanidine. pimagedine 114-128 vasoactive intestinal polypeptide Mus musculus 28-31 16441241-10 2006 The effects of IL-1beta were abolished by aminoguanidine, a selective inhibitor of inducible NOS (nitric oxide synthase), or by rofecoxib, a specific inhibitor of COX-2 (cyclo-oxygenase 2). pimagedine 42-56 interleukin 1 beta Mus musculus 15-23 15617031-1 2006 Aminoguanidine is an inhibitor of nitric oxide synthase (NOS), with high selectivity for the inducible isoform (iNOS). pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 112-116 16537416-4 2006 Radical adduct formation was suppressed by aminoguanidine, N-(3-aminomethyl)benzylacetamidine (1400W), or allopurinol, suggesting a role for both inducible nitric oxide synthase (iNOS) and xanthine oxidase (XO) in free radical formation. pimagedine 43-57 nitric oxide synthase 2, inducible Mus musculus 146-177 16537416-4 2006 Radical adduct formation was suppressed by aminoguanidine, N-(3-aminomethyl)benzylacetamidine (1400W), or allopurinol, suggesting a role for both inducible nitric oxide synthase (iNOS) and xanthine oxidase (XO) in free radical formation. pimagedine 43-57 nitric oxide synthase 2, inducible Mus musculus 179-183 16293701-10 2006 Selective inhibition of iNOS by aminoguanidine (45 mg/kg ip), which had no effect on baseline blood pressure, abolished both the hypotensive action of subsequently administered ethanol and the associated increases in aortic iNOS content. pimagedine 32-46 nitric oxide synthase 2 Rattus norvegicus 24-28 16049426-9 2006 Furthermore, the iNOS inhibitor aminoguanidine reduced infarct volume in male, but not in female, mice. pimagedine 32-46 nitric oxide synthase 2, inducible Mus musculus 17-21 16293701-10 2006 Selective inhibition of iNOS by aminoguanidine (45 mg/kg ip), which had no effect on baseline blood pressure, abolished both the hypotensive action of subsequently administered ethanol and the associated increases in aortic iNOS content. pimagedine 32-46 nitric oxide synthase 2 Rattus norvegicus 224-228 16317388-11 2005 Administration of aminoguanidine, a selective iNOS inhibitor, before AP induction abolished the protective effect of pretreatment with rmIL-18 on pancreatic injury. pimagedine 18-32 nitric oxide synthase 2, inducible Mus musculus 46-50 16464234-0 2006 Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia. pimagedine 0-14 caspase 3 Rattus norvegicus 24-33 16229859-10 2006 The administration of aminoguanidine (an inhibitor of glycation reactions) in the drinking water increased the activities of CAT, GPx and GR, suggesting that glycation may be responsible for the partial inactivation of these enzymes. pimagedine 22-36 catalase Rattus norvegicus 125-128 16612566-10 2006 85%), which was decreased by blockage of diamine oxidase through aminoguanidine. pimagedine 65-79 amine oxidase copper containing 1 Sus scrofa 41-56 16310374-5 2006 Endotoxin increased serum 6-keto-PGF(1alpha) levels diminished by L-arginine or aminoguanidine (iNOS inhibitor). pimagedine 80-94 nitric oxide synthase 2, inducible Mus musculus 96-100 16467878-7 2006 Moreover, when cells were treated with PD98059 under hypoxic conditions, uPAR was downregulated, whereas aminoguanidine markedly increased ERK phosphorylation in a dose dependent manner. pimagedine 105-119 mitogen-activated protein kinase 1 Homo sapiens 139-142 16467878-8 2006 Furthermore, aminoguanidine increased uPAR expression and prevented the inhibition of uPAR expression by PD98059. pimagedine 13-27 plasminogen activator, urokinase receptor Homo sapiens 38-42 16467878-8 2006 Furthermore, aminoguanidine increased uPAR expression and prevented the inhibition of uPAR expression by PD98059. pimagedine 13-27 plasminogen activator, urokinase receptor Homo sapiens 86-90 16359183-1 2005 It is established that aminoguanidine (AG), diaminoguanidine (DAG), and NG-amino-l-arginine (NAA) are metabolism-based inactivators of the three major isoforms of nitric oxide synthase (NOS). pimagedine 23-37 nitric oxide synthase 1 Homo sapiens 163-184 16425447-5 2005 Treatments with the different concentrations of diamine oxidase inhibitors (2-hydroxyethylhydrazine and aminoguanidine) under the light condition inhibited diamine oxidase activity, and decreased the contents of H2O2 and lignin. pimagedine 104-118 copper amino oxidase Glycine max 48-63 16425447-5 2005 Treatments with the different concentrations of diamine oxidase inhibitors (2-hydroxyethylhydrazine and aminoguanidine) under the light condition inhibited diamine oxidase activity, and decreased the contents of H2O2 and lignin. pimagedine 104-118 copper amino oxidase Glycine max 156-171 16395420-1 2005 Our objective was to study the effect of inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (AG) on microvascular permeability after cerebral ischemia/reperfusion (I/R) injury. pimagedine 90-104 nitric oxide synthase 2 Homo sapiens 41-72 16395420-1 2005 Our objective was to study the effect of inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (AG) on microvascular permeability after cerebral ischemia/reperfusion (I/R) injury. pimagedine 90-104 nitric oxide synthase 2 Homo sapiens 74-78 16556410-10 2006 Aminoguanidin has an interventional effect in our CCl4 induced rat liver fibrosis model. pimagedine 0-13 C-C motif chemokine ligand 4 Rattus norvegicus 50-54 16434757-8 2006 Aminoguanidine (an iNOS inhibitor) and methylene blue (a guanylyl cyclase inhibitor) inhibited the relaxations. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 19-23 16523632-11 2006 In Experiment 3, we compared the total plasma NO responses to LPS in the presence and absence of aminoguanidine (AG), a selective inhibitor of iNOS. pimagedine 97-111 nitric oxide synthase 2 Homo sapiens 143-147 16411654-2 2006 Aldehyde oxidase (AOX) was recently identified as the imidacloprid nitroreductase of mammalian liver, producing both nitrosoguanidine and aminoguanidine metabolites. pimagedine 138-152 aldehyde oxidase 1 Homo sapiens 0-16 16411654-2 2006 Aldehyde oxidase (AOX) was recently identified as the imidacloprid nitroreductase of mammalian liver, producing both nitrosoguanidine and aminoguanidine metabolites. pimagedine 138-152 aldehyde oxidase 1 Homo sapiens 18-21 16546926-5 2006 In this experimental study, we explore the effect of specific iNOS inhibitor aminoguanidine (AG) on blood and tissue (liver and renal) LP and iNOS levels in jaundiced rats with endotoxemia induced with lipopolysaccharide (LPS). pimagedine 77-91 nitric oxide synthase 2 Rattus norvegicus 62-66 17162536-5 2006 A second goal was to compare the observed protective effects of calpain inhibition with a relatively selective inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (AG) and an inhibitor of coagulation, heparin. pimagedine 160-174 nitric oxide synthase 2 Rattus norvegicus 144-148 16154689-2 2005 Moreover, aminoguanidine, which is a selective iNOS inhibitor, was administrated immediately following ischemia and every 24h thereafter for 7 days to investigate whether the production of NO is dependent on the iNOS pathway. pimagedine 10-24 nitric oxide synthase 2 Homo sapiens 47-51 16154689-5 2005 The administration of aminoguanidine reduced the oxidative NO metabolites on day 1 and suppressed the expression of iNOS. pimagedine 22-36 nitric oxide synthase 2 Homo sapiens 116-120 16125422-4 2005 In preliminary primary infection experiments, NIH inbred mice treated with aminoguanidine, an inhibitor of inducible nitric oxide synthase (iNOS), experienced no changes in post-infection tear, brain, or ganglia virus titers, but encephalitis-related mortality was elevated. pimagedine 75-89 nitric oxide synthase 2, inducible Mus musculus 107-138 16125422-4 2005 In preliminary primary infection experiments, NIH inbred mice treated with aminoguanidine, an inhibitor of inducible nitric oxide synthase (iNOS), experienced no changes in post-infection tear, brain, or ganglia virus titers, but encephalitis-related mortality was elevated. pimagedine 75-89 nitric oxide synthase 2, inducible Mus musculus 140-144 16271941-6 2005 The copresence of VEGF165 with aminoguanidine (iNOS inhibitor) determined an increase of eNOS and a significant increase in thymidine incorporation. pimagedine 31-45 nitric oxide synthase 2 Homo sapiens 47-51 16416608-0 2005 Induction of vascular endothelial growth factor messenger ribonucleic acid expression in stored micrografts by aminoguanidine. pimagedine 111-125 vascular endothelial growth factor A Homo sapiens 13-47 16183390-11 2005 Aminoguanidine, a selective iNOS inhibitor, blocked the decrease in PKC-alpha translocation and detrusor contractions induced by LPS. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 28-32 16183390-11 2005 Aminoguanidine, a selective iNOS inhibitor, blocked the decrease in PKC-alpha translocation and detrusor contractions induced by LPS. pimagedine 0-14 protein kinase C, alpha Rattus norvegicus 68-77 16132725-11 2005 In conclusion, this study indicates that iNOS inhibitor, AMG, show reduction in NO"s side effect in I/R injury. pimagedine 57-60 nitric oxide synthase 2 Rattus norvegicus 41-45 16202171-6 2005 Some of the mice in each feeding group were in addition given aminoguanidine (AG), a specific inhibitor of diamine oxidase, which catalyses degradation of putrescine, and also inhibits non-enzymatic glycosylation of protein which is implicated in the aetiology of atherosclerosis in diabetic patients. pimagedine 62-76 amine oxidase, copper-containing 1 Mus musculus 107-122 16179009-9 2005 The importance of NO in systemic infection with the mutant strain was confirmed by the strong increase in the susceptibility of aminoguanidine (an iNOs inhibitor)-treated mice. pimagedine 128-142 nitric oxide synthase 2, inducible Mus musculus 147-151 16109516-9 2005 Aminoguanidine and FK506 can inhibit the expression of iNOS and palliate acute rejection. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 55-59 15937288-9 2005 Finally, Evans blue albumin accumulation in lungs of WT mice was significant (50 vs. 15% increase in iNOS(-/-) mice compared with control animals) in response to MV and was prevented by treatment of the animals with the iNOS inhibitor aminoguanidine. pimagedine 235-249 nitric oxide synthase 2, inducible Mus musculus 101-105 15937288-9 2005 Finally, Evans blue albumin accumulation in lungs of WT mice was significant (50 vs. 15% increase in iNOS(-/-) mice compared with control animals) in response to MV and was prevented by treatment of the animals with the iNOS inhibitor aminoguanidine. pimagedine 235-249 nitric oxide synthase 2, inducible Mus musculus 220-224 16014616-7 2005 In IL-10-deficient mice, aminoguanidine, which inhibits iNOS, protected against vasomotor dysfunction after LPS. pimagedine 25-39 interleukin 10 Mus musculus 3-8 16014616-7 2005 In IL-10-deficient mice, aminoguanidine, which inhibits iNOS, protected against vasomotor dysfunction after LPS. pimagedine 25-39 nitric oxide synthase 2, inducible Mus musculus 56-60 16014616-7 2005 In IL-10-deficient mice, aminoguanidine, which inhibits iNOS, protected against vasomotor dysfunction after LPS. pimagedine 25-39 toll-like receptor 4 Mus musculus 108-111 16094491-3 2005 Three parts were performed in the present experiment: (1) To determine the effects of pretreatment with aspirin against heatstroke;(2) To prove the effects of specifically reducing inducible nitric oxide synthase (iNOS) against rat heatstroke by iNOS selective prohibitor aminoguanidine (AG);(3) To determine the effects of aspirin against heatstroke and fatigue. pimagedine 272-286 nitric oxide synthase 2 Rattus norvegicus 181-212 16094491-3 2005 Three parts were performed in the present experiment: (1) To determine the effects of pretreatment with aspirin against heatstroke;(2) To prove the effects of specifically reducing inducible nitric oxide synthase (iNOS) against rat heatstroke by iNOS selective prohibitor aminoguanidine (AG);(3) To determine the effects of aspirin against heatstroke and fatigue. pimagedine 272-286 nitric oxide synthase 2 Rattus norvegicus 214-218 15894170-4 2005 LPS/IFN-gamma-induced COX-2 expression in mesangial cells could be inhibited by iNOS inhibitor, aminoguanidine. pimagedine 96-110 interferon gamma Homo sapiens 4-13 15894170-4 2005 LPS/IFN-gamma-induced COX-2 expression in mesangial cells could be inhibited by iNOS inhibitor, aminoguanidine. pimagedine 96-110 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-27 15894170-4 2005 LPS/IFN-gamma-induced COX-2 expression in mesangial cells could be inhibited by iNOS inhibitor, aminoguanidine. pimagedine 96-110 nitric oxide synthase 2 Homo sapiens 80-84 15921695-4 2005 The aim of this study was to determine if the subsequent vasodilation was due to the release of a direct vasodilator or production of NO in the arteriole and if its source was iNOS by using its selective inhibitor, aminoguanidine. pimagedine 215-229 nitric oxide synthase 2 Rattus norvegicus 176-180 16153419-15 2005 COX-2 inhibition with NS-398 as well as iNOS inhibition with aminoguanidine diminished LPS-induced changes in aspartate aminotransferase and alanine aminotransferase levels. pimagedine 61-75 nitric oxide synthase 2 Rattus norvegicus 40-44 16153419-15 2005 COX-2 inhibition with NS-398 as well as iNOS inhibition with aminoguanidine diminished LPS-induced changes in aspartate aminotransferase and alanine aminotransferase levels. pimagedine 61-75 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 110-136 15746162-10 2005 Inhibition of iNOS or cyclooxygenase 2 activity using aminoguanidine or NS-398 respectively, demonstrated that NO did not affect PG production nor did PGs influence NO production. pimagedine 54-68 nitric oxide synthase 2, inducible Mus musculus 14-18 15746162-10 2005 Inhibition of iNOS or cyclooxygenase 2 activity using aminoguanidine or NS-398 respectively, demonstrated that NO did not affect PG production nor did PGs influence NO production. pimagedine 54-68 prostaglandin-endoperoxide synthase 2 Mus musculus 22-38 15925283-8 2005 The iNOS inhibitor aminoguanidine significantly suppressed the induction of HO-1. pimagedine 19-33 nitric oxide synthase 2 Rattus norvegicus 4-8 15925283-8 2005 The iNOS inhibitor aminoguanidine significantly suppressed the induction of HO-1. pimagedine 19-33 heme oxygenase 1 Rattus norvegicus 76-80 16079011-6 2005 Aminoguanidine, an inhibitor of iNOS, attenuated all these effects. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 32-36 15598843-11 2005 Other related changes observed in the PTCs that could be reversed by treatment with either aminoguanidine, pyridoxamine, rotenone, apocynin, or DPI included an increase in transforming growth factor-beta1 secretion and the activation of the NF-kappaB signal transduction pathway. pimagedine 91-105 transforming growth factor beta 1 Homo sapiens 172-204 16159718-4 2005 Treatment with aminoguanidine sulfate (AG), an inhibitor of iNOS, resulted in extensive corneal destruction, reduced nitrite levels, and reduced nitrotyrosine staining. pimagedine 15-37 nitric oxide synthase 2, inducible Mus musculus 60-64 15857407-5 2005 ApoJ increased the secretion of reactive nitrogen intermediates in a dose-dependent manner (EC(50) 112 nm), which was completely blocked by aminoguanidine (AG), a nitric oxide synthase inhibitor. pimagedine 140-154 clusterin Homo sapiens 0-4 15702482-10 2005 NOS inhibitors aminoguanidine or N(G)-nitro-L-arginine, simultaneously injected with LPS, reduced the iNOS immunoreactivity and infarct volume, especially in penumbra regions. pimagedine 15-29 nitric oxide synthase 2 Rattus norvegicus 102-106 15698434-9 2005 Aminoguanidine and vitamin E prevented AGE accumulation and induction of protein and mRNA for fibrosis markers [transforming growth factor-beta1 (TGF-beta1), fibronectin, and collagen IV]. pimagedine 0-14 transforming growth factor, beta 1 Rattus norvegicus 112-144 15804287-9 2005 IFN-gamma and NO appear to mediate this antiproliferative effect because this effect was not observed in the presence of mDCs from IFN-gamma-/- or IL-12/IL-23-/- IFN-gamma-/- mice and it was attenuated by aminoguanidine. pimagedine 205-219 interferon gamma Mus musculus 0-9 15790897-5 2005 Finally, an NOS-2 inhibitor, aminoguanidine, administered orally in the drinking water, was tested for its effect on optic nerve injury in rats with ocular hypertension. pimagedine 29-43 nitric oxide synthase 2 Rattus norvegicus 12-17 15539418-9 2005 We previously demonstrated that anti-TNF-alpha antibody and aminoguanidine, a selective inhibitor of iNOS, reduced LPS-induced hypotension in this animal model. pimagedine 60-74 nitric oxide synthase 2 Rattus norvegicus 101-105 15689953-9 2005 Treatment with the iNOS inhibitor aminoguanidine (400 mg/kg), abolished the IPC-induced protection. pimagedine 34-48 nitric oxide synthase 2, inducible Mus musculus 19-23 15721986-9 2005 Treatment of INS-1 cells with the iNOS inhibitor aminoguanidine protected these cells from mtDNA damage and diminished the appearance of apoptosis. pimagedine 49-63 nitric oxide synthase 2 Rattus norvegicus 34-38 15698434-9 2005 Aminoguanidine and vitamin E prevented AGE accumulation and induction of protein and mRNA for fibrosis markers [transforming growth factor-beta1 (TGF-beta1), fibronectin, and collagen IV]. pimagedine 0-14 transforming growth factor, beta 1 Rattus norvegicus 146-155 15698434-9 2005 Aminoguanidine and vitamin E prevented AGE accumulation and induction of protein and mRNA for fibrosis markers [transforming growth factor-beta1 (TGF-beta1), fibronectin, and collagen IV]. pimagedine 0-14 fibronectin 1 Rattus norvegicus 158-169 15664123-6 2005 Inhibition of iNOS activity by selective iNOS inhibitors, aminoguanidine and 1400W, reduces OGD-R-induced apoptotic cell death, as demonstrated by the decrease of LDH release, cytochrome C release, and caspase-3 activity. pimagedine 58-72 nitric oxide synthase 2 Rattus norvegicus 14-18 15664123-6 2005 Inhibition of iNOS activity by selective iNOS inhibitors, aminoguanidine and 1400W, reduces OGD-R-induced apoptotic cell death, as demonstrated by the decrease of LDH release, cytochrome C release, and caspase-3 activity. pimagedine 58-72 nitric oxide synthase 2 Rattus norvegicus 41-45 15664123-6 2005 Inhibition of iNOS activity by selective iNOS inhibitors, aminoguanidine and 1400W, reduces OGD-R-induced apoptotic cell death, as demonstrated by the decrease of LDH release, cytochrome C release, and caspase-3 activity. pimagedine 58-72 caspase 3 Rattus norvegicus 202-211 15984155-6 2005 Aminoguanidine (AG), a selective inhibitor for iNOS, suppressed cumulus expansion and inhibited CEOs to resume meiosis (p < 0.05), but did not inhibit cumulus cell DNA fragmentation. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 47-51 15591232-7 2005 Microinjection of aminoguanidine or S-methylisothiourea, iNOS inhibitors, or tempol, an antioxidant, significantly attenuated the pressor response evoked by iNOS gene transfer. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 157-161 15680278-7 2005 The results demonstrated that increases in plasma TNF-alpha and NO, and the vasohyporeactivity induced by lipopolysaccharide treatment were significantly inhibited by hyperbaric oxygen and aminoguanidine. pimagedine 189-203 tumor necrosis factor Rattus norvegicus 50-59 15544848-9 2005 Aminoguanidine administration did not modify somatostatin mRNA in saline injected rats, but it prevented LPS-induced increase in hypothalamic somatostatin mRNA. pimagedine 0-14 somatostatin Rattus norvegicus 142-154 15835536-1 2005 Inducible NO-synthase inhibitor aminoguanidine (AG) was used for investigation into enhanced nitric oxide (NO) production influence on elevated pressure in the pulmonary circulation (pulmonary hypertension, PH) under endothelial dysfunction. pimagedine 32-46 nitric oxide synthase 2 Rattus norvegicus 0-21 16392625-10 2005 Similar to healthy rats, the aminoguanidine-treated diabetic rats had very strong transforming growth factor (TGF)-beta1 expression in granulation tissue and intact skin in comparison with diabetic controls. pimagedine 29-43 transforming growth factor, beta 1 Rattus norvegicus 110-113 15899045-8 2005 However, co-stimulation with leptin and IL-1 resulted in a net increase in nitric oxide concentration over IL-1 challenge that was eliminated by pretreatment with the NOS II specific inhibitor aminoguanidine. pimagedine 193-207 interleukin 1 alpha Homo sapiens 40-44 15899045-8 2005 However, co-stimulation with leptin and IL-1 resulted in a net increase in nitric oxide concentration over IL-1 challenge that was eliminated by pretreatment with the NOS II specific inhibitor aminoguanidine. pimagedine 193-207 interleukin 1 alpha Homo sapiens 107-111 16201316-0 2005 Effect of aminoguanidine and albendazole on inducible nitric oxide synthase (iNOS) activity in T. spiralis-infected mice muscles. pimagedine 10-24 nitric oxide synthase 2, inducible Mus musculus 77-81 16392625-12 2005 In conclusion, aminoguanidine improves wound healing, restores growth factor TGF-beta1 expression, and preserves collagen ultra structure, whereas it has no prominent effect on NO levels within wound tissue in diabetic rats. pimagedine 15-29 transforming growth factor, beta 1 Rattus norvegicus 77-86 15639000-7 2005 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and ascorbic acid, an antioxidant, decreased IL-1beta, TNF-alpha contents and hyperglycaemia. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 19-50 15466365-3 2005 iNOS inhibition by 1400W, aminoguanidine, or L-NIL pretreatment further increased the cytokine/LPS-mediated lipolysis by 30% (P < 0.05) in cultured adipocytes and in adipose explants. pimagedine 26-40 nitric oxide synthase 2, inducible Mus musculus 0-4 15639000-7 2005 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and ascorbic acid, an antioxidant, decreased IL-1beta, TNF-alpha contents and hyperglycaemia. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 52-56 15639000-7 2005 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and ascorbic acid, an antioxidant, decreased IL-1beta, TNF-alpha contents and hyperglycaemia. pimagedine 0-14 interleukin 1 beta Rattus norvegicus 114-122 15639000-7 2005 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and ascorbic acid, an antioxidant, decreased IL-1beta, TNF-alpha contents and hyperglycaemia. pimagedine 0-14 tumor necrosis factor Rattus norvegicus 124-133 15633737-1 2004 UNLABELLED: The effect and possible mechanisms of action of aminoguanidine (a preferential iNOS inhibitor) has been studied on cardiovascular damages and overproduction of reactive nitrogen species in streptozotocin-induced diabetic rats. pimagedine 60-74 nitric oxide synthase 2 Rattus norvegicus 91-95 15607619-8 2004 Chronic blockade of iNOS activity by aminoguanidine resulted in significant up-regulation of HO-1, but the pressor effect was blunt. pimagedine 37-51 nitric oxide synthase 2 Rattus norvegicus 20-24 15607619-8 2004 Chronic blockade of iNOS activity by aminoguanidine resulted in significant up-regulation of HO-1, but the pressor effect was blunt. pimagedine 37-51 heme oxygenase 1 Rattus norvegicus 93-97 15213250-12 2004 Treatment with the AGE inhibitor aminoguanidine restored the expression of OCT-2 and OCT-3 in diabetic animals and normalized renal NMN clearance. pimagedine 33-47 POU class 2 homeobox 2 Rattus norvegicus 75-80 15514191-6 2004 To determine whether iNOS contributes to the toxicity of PARP, the iNOS inhibitor aminoguanidine was co-administered with PARP inhibitors. pimagedine 82-96 nitric oxide synthase 2, inducible Mus musculus 67-71 15533321-5 2004 Pre-treatment of rats with the iNOS inhibitor aminoguanidine (AG) decreased the extent of NMDA-induced striatal cell loss at 24 h and reduced 3-NT expression but was without effect on glial cell activation. pimagedine 46-60 nitric oxide synthase 2 Rattus norvegicus 31-35 15613746-2 2004 In the present study, we compared the effect of the selective iNOS inhibitor aminoguanidine and the nonselective NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) on a dextran sulfate sodium (DSS)-induced model of colitis in rats. pimagedine 77-91 nitric oxide synthase 2 Rattus norvegicus 62-66 15465034-3 2004 The decrease in the mRNA levels caused by LCM-induced inducible NO synthase (iNOS) was completely blocked by co-treatment with aminoguanidine, a selective iNOS inhibitor. pimagedine 127-141 nitric oxide synthase 2 Rattus norvegicus 54-75 15465034-3 2004 The decrease in the mRNA levels caused by LCM-induced inducible NO synthase (iNOS) was completely blocked by co-treatment with aminoguanidine, a selective iNOS inhibitor. pimagedine 127-141 nitric oxide synthase 2 Rattus norvegicus 77-81 15465034-3 2004 The decrease in the mRNA levels caused by LCM-induced inducible NO synthase (iNOS) was completely blocked by co-treatment with aminoguanidine, a selective iNOS inhibitor. pimagedine 127-141 nitric oxide synthase 2 Rattus norvegicus 155-159 15213250-12 2004 Treatment with the AGE inhibitor aminoguanidine restored the expression of OCT-2 and OCT-3 in diabetic animals and normalized renal NMN clearance. pimagedine 33-47 solute carrier family 22 member 8 Rattus norvegicus 85-90 15371279-1 2004 A nonselective inhibitor of cyclooxygenase (COX; high-dose aspirin) and a relatively selective inhibitor of inducible nitric oxide synthase (iNOS; aminoguanidine) have been found to inhibit development of diabetic retinopathy in animals, raising a possibility that NOS and COX play important roles in the development of retinopathy. pimagedine 147-161 nitric oxide synthase 2 Rattus norvegicus 108-139 15371279-1 2004 A nonselective inhibitor of cyclooxygenase (COX; high-dose aspirin) and a relatively selective inhibitor of inducible nitric oxide synthase (iNOS; aminoguanidine) have been found to inhibit development of diabetic retinopathy in animals, raising a possibility that NOS and COX play important roles in the development of retinopathy. pimagedine 147-161 nitric oxide synthase 2 Rattus norvegicus 141-145 15371279-13 2004 We postulate that NOS and COX-2 act together to contribute to retinal cell death in diabetes and to the development of diabetic retinopathy and that inhibition of retinopathy by aminoguanidine or aspirin is due at least in part to inhibition of this NO/COX-2 axis. pimagedine 178-192 cytochrome c oxidase II, mitochondrial Rattus norvegicus 253-258 15213153-5 2004 In contrast, both wild-type and Nos2(tm1Lau) mice died within 32 days postinfection when treated with the nitric oxide synthase inhibitor aminoguanidine. pimagedine 138-152 nitric oxide synthase 2, inducible Mus musculus 32-36 15059928-7 2004 Injection of EMT-6 J cells and simultaneous treatment of mice with aminoguanidine (AG), a NOS II inhibitor, significantly increased tumour formation. pimagedine 67-81 nitric oxide synthase 2, inducible Mus musculus 90-96 15350850-7 2004 Aminoguanidine, an inhibitor of iNOS, significantly attenuated these LPS-induced functional and metabolic changes. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 32-36 15240103-5 2004 Aminoguanidine and N-acetyl-L-cysteine also inhibited the MG-induced p38 MAPK activation and apoptosis along with restoration of the intracellular glutathione content. pimagedine 0-14 mitogen activated protein kinase 14 Rattus norvegicus 69-72 15256732-8 2004 Both iridoid total glycoside and aminoguanidine were effective in decreasing serum protein level and glomerular mRNA expression of TGF-beta1, and in preventing renal overdeposition of fibronectin and laminin. pimagedine 33-47 transforming growth factor, beta 1 Rattus norvegicus 131-140 15256732-8 2004 Both iridoid total glycoside and aminoguanidine were effective in decreasing serum protein level and glomerular mRNA expression of TGF-beta1, and in preventing renal overdeposition of fibronectin and laminin. pimagedine 33-47 fibronectin 1 Rattus norvegicus 184-195 15380597-7 2004 Radiosensitization was abrogated by the iNOS inhibitor aminoguanidine but not by a neutralizing anti-TNF-alpha antibody. pimagedine 55-69 nitric oxide synthase 2, inducible Mus musculus 40-44 15337263-5 2004 Administration of the inducible NOS (iNOS) inhibitor aminoguanidine (100 mg/kg i.p.) pimagedine 53-67 nitric oxide synthase 2 Rattus norvegicus 22-35 15337263-5 2004 Administration of the inducible NOS (iNOS) inhibitor aminoguanidine (100 mg/kg i.p.) pimagedine 53-67 nitric oxide synthase 2 Rattus norvegicus 37-41 15491848-6 2004 Aminoguanidine and erdosteine significantly prevented depletion of superoxide dismutase and glutathione peroxidase and elevated myeloperoxidase activities, malondialdehyde level in lung tissue produced by bleomycin. pimagedine 0-14 myeloperoxidase Rattus norvegicus 128-143 15240796-5 2004 The involvement of inducible nitric oxide synthase (iNOS) was shown by the inability of Abeta to inhibit LTP induction in iNOS knock-out mice and also by the ability of two iNOS inhibitors, aminoguanidine and 1400W, to prevent the Abeta-mediated inhibition of LTP induction. pimagedine 190-204 nitric oxide synthase 2, inducible Mus musculus 52-56 15542450-7 2004 Exogenously added NO inhibited CFU-E colony formation, whereas both L-NAME and aminoguanidine reversed the CFU-E suppression by IL-17 in a dose-dependent manner. pimagedine 79-93 interleukin 17A Mus musculus 128-133 15233965-5 2004 The method permitted the quantitative analyses of all three amines in rat hepatic tissue; the concentration of putrescine, but not spermidine, was increased significantly following a 14-day administration of the diamine oxidase (DAO) inhibitor aminoguanidine. pimagedine 244-258 amine oxidase, copper containing 1 Rattus norvegicus 212-227 15233965-5 2004 The method permitted the quantitative analyses of all three amines in rat hepatic tissue; the concentration of putrescine, but not spermidine, was increased significantly following a 14-day administration of the diamine oxidase (DAO) inhibitor aminoguanidine. pimagedine 244-258 amine oxidase, copper containing 1 Rattus norvegicus 229-232 15127403-8 2004 These endotoxin-related responses in the presence or absence of the Ti alloy implant could be inhibited by aminoguanidine (an iNOS inhibitor). pimagedine 107-121 nitric oxide synthase 2 Rattus norvegicus 126-130 15462215-2 2004 To examine the role of iNOS in MCT-induced PH, we used iNOS inhibitor: aminoguanidine (AG). pimagedine 71-85 nitric oxide synthase 2 Rattus norvegicus 55-59 15120566-6 2004 The selective iNOS inhibitors, S-methylthiourea (SMT) and aminoguanidine (AG), were administered in conjunction with opioid pretreatment or were also given 24 hours after opioid administration just prior to index ischemia. pimagedine 58-72 nitric oxide synthase 2 Rattus norvegicus 14-18 15081596-5 2004 Treatment with the iNOS inhibitor aminoguanidine attenuated QA-mediated striatal lesions and reduced oxidative damage, indicating that iNOS activation may be involved in the striatal oxidative damage induced by QA. pimagedine 34-48 inositol-3-phosphate synthase 1 Homo sapiens 19-23 15081596-5 2004 Treatment with the iNOS inhibitor aminoguanidine attenuated QA-mediated striatal lesions and reduced oxidative damage, indicating that iNOS activation may be involved in the striatal oxidative damage induced by QA. pimagedine 34-48 inositol-3-phosphate synthase 1 Homo sapiens 135-139 21166207-5 2004 The observation of pathologic changes of liver was made following the inhibition of iNOS by aminoguanidine (AG). pimagedine 92-106 nitric oxide synthase 2 Rattus norvegicus 84-88 15153651-9 2004 Delaying onset of aminoguanidine administration (i.e., 0 or 30 min after the start of heat exposure) reduced the preventive efficiency on heatstroke-induced hyperthermia, arterial hypotension, intracranial hypertension, cerebral ischemia, and increased iNOS-dependent NO formation in brain. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 253-257 15153651-10 2004 These results suggest that aminoguanidine protects against heatstroke-induced intracranial hypertension and cerebral ischemic injury by inhibition of cerebral iNOS-dependent NO production. pimagedine 27-41 nitric oxide synthase 2 Rattus norvegicus 159-163 15081619-1 2004 Here, we studied the effect of aminoguanidine (AG) treatment, a nitric oxide synthase (NOS)-2 inhibitor, during the immune response against intranasal administration of ovalbumin (OVA) mixed with cholera toxin (CT) in BALB/c mice. pimagedine 31-45 nitric oxide synthase 2, inducible Mus musculus 64-93 15081619-1 2004 Here, we studied the effect of aminoguanidine (AG) treatment, a nitric oxide synthase (NOS)-2 inhibitor, during the immune response against intranasal administration of ovalbumin (OVA) mixed with cholera toxin (CT) in BALB/c mice. pimagedine 31-45 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 169-178 15036557-3 2004 In this model, the pharmacological use of an inhibitor of NOS-2, aminoguanidine, significantly prevents the loss of retinal ganglion cells. pimagedine 65-79 nitric oxide synthase 2 Homo sapiens 58-63 14633657-4 2004 When applied topically onto shaven backs of mice 30 min prior to TPA, the NOS inhibitor aminoguanidine (AG) inhibited the expression of COX-2 protein at the pharmacologically effective dose. pimagedine 88-102 prostaglandin-endoperoxide synthase 2 Mus musculus 136-141 14555681-9 2004 Aminoguanidine, an inhibitor of iNOS, significantly attenuated the LPS-induced NOx production and contractile dysfunction. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 32-36 14973050-9 2004 Conversely, the resistance-inducing effect of the fibroblasts was significantly abolished, when the specific iNOS inhibitor aminoguanidine was added during coculture. pimagedine 124-138 nitric oxide synthase 2 Homo sapiens 109-113 15037528-6 2004 Specific inhibition of NOS2 by aminoguanidine (AG) or L-NIL dramatically increased the ISO-induced inotropy and lusitropy, such that the ISO+AG response in HF approached that seen with ISO alone in nonfailing human myocytes or muscles. pimagedine 31-45 nitric oxide synthase 2 Homo sapiens 23-27 14980620-8 2004 However, the 1-carboximidamides, which represent more structurally related semicyclic derivatives of aminoguanidine, caused only incomplete iNOS inhibition. pimagedine 101-115 nitric oxide synthase 2 Rattus norvegicus 140-144 14733914-4 2004 An aldose reductase inhibitor (ARI), SNK-860, significantly inhibited all of these abnormalities, while aminoguanidine suppressed 3-DG levels and HB-EGF mRNA expression independent of sorbitol levels. pimagedine 104-118 heparin-binding EGF-like growth factor Rattus norvegicus 146-152 14685005-7 2004 The estimated glomerular filtration rate decreased more slowly in the pimagedine-treated patients with a 36-month decrease from baseline of 6.26 ml/min/1.73 m(2) as compared with 9.80 ml/min/1.73 m(2) in the placebo-treated patients (p = 0.05), and pimagedine reduced the 24-hour total urinary proteinuria. pimagedine 70-80 CD59 molecule (CD59 blood group) Homo sapiens 148-153 14729054-9 2004 Inhibitors of lipooxidation end products formation such as piridoxamine (PM) and aminoguanidine (AG) block NO-triggered carbonylation of Bcl-2, ANT and GAPDH, prevent NO-induced GAPDH enzyme inhibition and nuclear translocation and DNA fragmentation. pimagedine 81-95 BCL2, apoptosis regulator Rattus norvegicus 137-142 14729054-9 2004 Inhibitors of lipooxidation end products formation such as piridoxamine (PM) and aminoguanidine (AG) block NO-triggered carbonylation of Bcl-2, ANT and GAPDH, prevent NO-induced GAPDH enzyme inhibition and nuclear translocation and DNA fragmentation. pimagedine 81-95 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 152-157 14729054-9 2004 Inhibitors of lipooxidation end products formation such as piridoxamine (PM) and aminoguanidine (AG) block NO-triggered carbonylation of Bcl-2, ANT and GAPDH, prevent NO-induced GAPDH enzyme inhibition and nuclear translocation and DNA fragmentation. pimagedine 81-95 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 178-183 14727007-6 2004 In addition, agmatine metabolism by diamine oxidase seems not to be involved in the inhibition of cell growth and proliferation because the diamine oxidase inhibitor aminoguanidine did not alter agmatine"s antiproliferative action. pimagedine 166-180 amine oxidase, copper containing 1 Rattus norvegicus 140-155 13129855-5 2004 The LPS-induced decrease in serum concentrations of IGF-I and liver IGF-I gene expression seems to be secondary to iNOS activation, since aminoguanidine administration prevented the effect of LPS on circulating IGF-I and its gene expression in the liver. pimagedine 138-152 nitric oxide synthase 2 Rattus norvegicus 115-119 13129855-8 2004 Aminoguanidine administration blocked the inhibitory effect of LPS on both IGFBP-3 serum levels and its hepatic mRNA levels. pimagedine 0-14 insulin-like growth factor binding protein 3 Rattus norvegicus 75-82 13129855-9 2004 When aminoguanidine was administered alone, IGFBP-3 serum levels were increased (P < 0.05), whereas its hepatic mRNA levels were decreased. pimagedine 5-19 insulin-like growth factor binding protein 3 Rattus norvegicus 44-51 15302995-5 2004 In addition, nitric oxide synthase (NOS) inhibitors, Nomega monomethyl L-arginine and aminoguanidine, also reduced LMM3-induced angiogenesis and nitric oxide (NO) synthesis as well. pimagedine 86-100 nitric oxide synthase 1, neuronal Mus musculus 13-34 14685005-7 2004 The estimated glomerular filtration rate decreased more slowly in the pimagedine-treated patients with a 36-month decrease from baseline of 6.26 ml/min/1.73 m(2) as compared with 9.80 ml/min/1.73 m(2) in the placebo-treated patients (p = 0.05), and pimagedine reduced the 24-hour total urinary proteinuria. pimagedine 70-80 CD59 molecule (CD59 blood group) Homo sapiens 187-192 14647892-8 2004 TGFbeta1 expression as assessed by in situ hybridisation was increased in the diabetic rats and reduced by perindopril and aminoguanidine. pimagedine 123-137 transforming growth factor, beta 1 Rattus norvegicus 0-8 15106808-5 2004 Dimethylguanidine or aminoguanidine were used to affect NO synthesis by iNOS. pimagedine 21-35 nitric oxide synthase 2 Rattus norvegicus 72-76 15479132-3 2004 The present study was performed to investigate whether the increase in nitric oxide production via inducible nitric oxide synthase was suppressed by the administration of aminoguanidine, a selective iNOS inhibitor, as it follows a decrease of NADPH-diaphorase activity (a marker for NOS) after four-vessel occlusion used as an ischemic model. pimagedine 171-185 nitric oxide synthase 2 Rattus norvegicus 99-130 15106808-10 2004 Aminoguanidine (a selective iNOS inhibitor) caused a substantial BP rise in L-NAME hypertensive rats only. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 28-32 14749478-7 2004 Aminoguanidine, an inducible nitric oxide synthase (NOS) inhibitor, given before C5aAP returned VP to control levels. pimagedine 0-14 nitric oxide synthase 1, neuronal Mus musculus 29-50 15067210-5 2004 RESULTS: The present work shows that iNOS inhibitor, aminoguanidine, reduced NO and PGE(2)/PGF(2alpha) production induced by LPS injection. pimagedine 53-67 nitric oxide synthase 2 Rattus norvegicus 37-41 15067210-6 2004 Aminoguanidine exerts its effect over the PG metabolism by inhibiting COX-II activity and expression. pimagedine 0-14 cytochrome c oxidase II, mitochondrial Rattus norvegicus 70-76 15339503-0 2004 [Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats]. pimagedine 35-49 vascular endothelial growth factor A Rattus norvegicus 67-101 14732351-2 2004 METHODS AND RESULTS: Treatment of interleukin-1beta-stimulated RA-SMC with aminoguanidine led to an increase of 96% in MMP-9 activity (P = 0.003) by gelatin zymography, a 40% increase in pro-MMP-9 protein (P = 0.018) by Western blot, and a 155% increase in MMP-9 mRNA (P = 0.06) by reverse transcription polymerase chain reaction. pimagedine 75-89 interleukin 1 beta Rattus norvegicus 34-51 14732351-2 2004 METHODS AND RESULTS: Treatment of interleukin-1beta-stimulated RA-SMC with aminoguanidine led to an increase of 96% in MMP-9 activity (P = 0.003) by gelatin zymography, a 40% increase in pro-MMP-9 protein (P = 0.018) by Western blot, and a 155% increase in MMP-9 mRNA (P = 0.06) by reverse transcription polymerase chain reaction. pimagedine 75-89 matrix metallopeptidase 9 Rattus norvegicus 119-124 14732351-2 2004 METHODS AND RESULTS: Treatment of interleukin-1beta-stimulated RA-SMC with aminoguanidine led to an increase of 96% in MMP-9 activity (P = 0.003) by gelatin zymography, a 40% increase in pro-MMP-9 protein (P = 0.018) by Western blot, and a 155% increase in MMP-9 mRNA (P = 0.06) by reverse transcription polymerase chain reaction. pimagedine 75-89 matrix metallopeptidase 9 Rattus norvegicus 191-196 14732351-2 2004 METHODS AND RESULTS: Treatment of interleukin-1beta-stimulated RA-SMC with aminoguanidine led to an increase of 96% in MMP-9 activity (P = 0.003) by gelatin zymography, a 40% increase in pro-MMP-9 protein (P = 0.018) by Western blot, and a 155% increase in MMP-9 mRNA (P = 0.06) by reverse transcription polymerase chain reaction. pimagedine 75-89 matrix metallopeptidase 9 Rattus norvegicus 191-196 14732351-3 2004 Aminoguanidine also caused a 26% decrease in cytosolic IkappaB levels (P = 0.014) by Western blot, as well as a 97% increase in nuclear factor-kappaB binding and a 216% increase in activator protein-1 binding as measured by electrophoretic mobility shift assay. pimagedine 0-14 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 181-200 15339503-7 2004 CONCLUSION: The therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy may be inhibiting the over-expression of VEGF in kidney of diabetic rats. pimagedine 65-79 vascular endothelial growth factor A Rattus norvegicus 145-149 15479132-3 2004 The present study was performed to investigate whether the increase in nitric oxide production via inducible nitric oxide synthase was suppressed by the administration of aminoguanidine, a selective iNOS inhibitor, as it follows a decrease of NADPH-diaphorase activity (a marker for NOS) after four-vessel occlusion used as an ischemic model. pimagedine 171-185 nitric oxide synthase 2 Rattus norvegicus 199-203 14636180-7 2003 Arthritis increased hypothalamic expression of somatostatin mRNA while it decreased pituitary GH mRNA expression, and both effects were prevented by aminoguanidine administration. pimagedine 149-163 somatostatin Rattus norvegicus 47-59 14637201-0 2003 Aminoguanidine downregulates expression of cytokine-induced Fas and inducible nitric oxide synthase but not cytokine-enhanced surface antigens of rat islet cells. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 68-99 14637201-4 2003 The iNOS inhibitor aminoguanidine (AG) delays diabetes onset, but does not reduce diabetes incidence. pimagedine 19-33 nitric oxide synthase 2 Rattus norvegicus 4-8 12919932-5 2003 First, the inducible nitric oxide inhibitor aminoguanidine prevents angiotensin II-induced DNA damage and apoptosis. pimagedine 44-58 angiotensinogen Homo sapiens 68-82 14644455-3 2003 The purpose of the present study was to investigate the role of nitric oxide (*NO) in cisplatin ototoxicity by administering aminoguanidine (AG), a relatively specific inhibitor of inducible nitric oxide synthase (iNOS), in conjunction with cisplatin. pimagedine 125-139 nitric oxide synthase 2 Rattus norvegicus 181-212 14644455-3 2003 The purpose of the present study was to investigate the role of nitric oxide (*NO) in cisplatin ototoxicity by administering aminoguanidine (AG), a relatively specific inhibitor of inducible nitric oxide synthase (iNOS), in conjunction with cisplatin. pimagedine 125-139 nitric oxide synthase 2 Rattus norvegicus 214-218 14636180-10 2003 However, aminoguanidine administration to control rats resulted in a decrease in serum GH concentrations and in a decrease in both hepatic IGF-I mRNA expression and serum IGF-I concentrations. pimagedine 9-23 insulin-like growth factor 1 Rattus norvegicus 139-144 14561852-6 2003 HO-1 expression by zymosan treatment was partly reduced by aminoguanidine, suggesting the participation of endogenous nitric oxide in the mechanisms leading to HO-1 synthesis in the zymosan-injected mouse air pouch. pimagedine 59-73 heme oxygenase 1 Mus musculus 0-4 14561852-6 2003 HO-1 expression by zymosan treatment was partly reduced by aminoguanidine, suggesting the participation of endogenous nitric oxide in the mechanisms leading to HO-1 synthesis in the zymosan-injected mouse air pouch. pimagedine 59-73 heme oxygenase 1 Mus musculus 160-164 14636180-10 2003 However, aminoguanidine administration to control rats resulted in a decrease in serum GH concentrations and in a decrease in both hepatic IGF-I mRNA expression and serum IGF-I concentrations. pimagedine 9-23 insulin-like growth factor 1 Rattus norvegicus 171-176 14642797-0 2003 Effect of inducible nitric oxide synthase inhibition by aminoguanidine on insulin-like growth factor binding protein-3 in adjuvant-induced arthritic rats. pimagedine 56-70 insulin-like growth factor binding protein 3 Rattus norvegicus 74-118 14615616-2 2003 Inducible nitric oxide synthase (iNOS) is expressed in human and rat cerebral aneurysms, and aminoguanidine, a relatively selective inhibitor of iNOS, can decrease the number of the aneurysms in rats. pimagedine 93-107 nitric oxide synthase 2 Rattus norvegicus 145-149 14557367-7 2003 In an ex vivo system, the cytokine-induced hyporesponsiveness of aortas to phenylephrine was significantly augmented in TP-/- aorta but was almost completely canceled by aminoguanidine, an iNOS inhibitor. pimagedine 170-184 nitric oxide synthase 2, inducible Mus musculus 189-193 14642797-3 2003 The increase in serum levels of IGFBP-3 induced by arthritis was exacerbated by aminoguanidine treatment. pimagedine 80-94 insulin-like growth factor binding protein 3 Rattus norvegicus 32-39 14642797-6 2003 However, the inhibitory effect of arthritis on the proteolysis of IGFBP-3 in serum was potentiated by aminoguanidine administration. pimagedine 102-116 insulin-like growth factor binding protein 3 Rattus norvegicus 66-73 14521919-6 2003 The expressions of p67 and p47(phox) were reduced by the addition of apocynin, aminoguanidine or ONO 1714 whereas xanthine oxidase and cyclooxygenase did not have a major role in superoxide production. pimagedine 79-93 CD33 molecule Homo sapiens 19-22 14656068-5 2003 at 3 and 9 h) after moderate contusive injury decreased the number of iNOS immunoreactive cells at the injury site by 65.6% (iNOS ASOs), 62.1% (1400 W), or 59% (aminoguanidine) 24 h postinjury. pimagedine 161-175 nitric oxide synthase 2 Rattus norvegicus 70-74 14656068-6 2003 iNOS activity was reduced 81.8% (iNOS ASOs), 56.7% (1400 W), or 67.9% (aminoguanidine) at this time. pimagedine 71-85 nitric oxide synthase 2 Rattus norvegicus 0-4 14529784-8 2003 The radiosensitivity of hypoxic EMT-6 cells was increased up to 2.5 times and counteracted by the iNOS inhibitor aminoguanidine but not by the COX-2 inhibitor NS-398. pimagedine 113-127 IL2 inducible T cell kinase Mus musculus 32-35 14529784-8 2003 The radiosensitivity of hypoxic EMT-6 cells was increased up to 2.5 times and counteracted by the iNOS inhibitor aminoguanidine but not by the COX-2 inhibitor NS-398. pimagedine 113-127 nitric oxide synthase 2, inducible Mus musculus 98-102 14732339-3 2003 Treatment of rats with non-selective, NG-nitro-L-arginine (nitro), or selective inducible NO synthase (iNOS), aminoguanidine (amino) inhibitors enhanced neutrophil migration 6h after the administration of low, but not high, doses of carrageenan (Cg) or Escherichia coli endotoxin (LPS). pimagedine 110-124 nitric oxide synthase 2 Rattus norvegicus 80-101 14732339-3 2003 Treatment of rats with non-selective, NG-nitro-L-arginine (nitro), or selective inducible NO synthase (iNOS), aminoguanidine (amino) inhibitors enhanced neutrophil migration 6h after the administration of low, but not high, doses of carrageenan (Cg) or Escherichia coli endotoxin (LPS). pimagedine 110-124 nitric oxide synthase 2 Rattus norvegicus 103-107 14521919-6 2003 The expressions of p67 and p47(phox) were reduced by the addition of apocynin, aminoguanidine or ONO 1714 whereas xanthine oxidase and cyclooxygenase did not have a major role in superoxide production. pimagedine 79-93 pleckstrin Homo sapiens 27-30 14501785-2 2003 We determined if advanced glycation end products (AGEs) are involved in ED and investigated if the selective AGE and inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (AG) could protect against the development of ED in a diabetic rat model. pimagedine 166-180 nitric oxide synthase 2 Rattus norvegicus 117-148 12738625-10 2003 The use of a pharmacological approach to inhibit iNOS (aminoguanidine, given ip) in additional wild-type shams and burns confirmed the iNOS KO data. pimagedine 55-69 nitric oxide synthase 2, inducible Mus musculus 49-53 12738625-10 2003 The use of a pharmacological approach to inhibit iNOS (aminoguanidine, given ip) in additional wild-type shams and burns confirmed the iNOS KO data. pimagedine 55-69 nitric oxide synthase 2, inducible Mus musculus 135-139 14534151-3 2003 The iNOS inhibitor aminoguanidine (0.1 mm) increased 5-HT contraction from hour three of LPS incubation. pimagedine 19-33 nitric oxide synthase 2 Rattus norvegicus 4-8 14501785-2 2003 We determined if advanced glycation end products (AGEs) are involved in ED and investigated if the selective AGE and inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (AG) could protect against the development of ED in a diabetic rat model. pimagedine 166-180 nitric oxide synthase 2 Rattus norvegicus 150-154 14503886-0 2003 Paradoxical protective effect of aminoguanidine toward low-density lipoprotein oxidation: inhibition of apolipoprotein B fragmentation without preventing its carbonylation. pimagedine 33-47 apolipoprotein B Homo sapiens 104-120 14551033-5 2003 Infiltrations of CD11b+, MOMA-2+ cells and neutrophils were significantly reduced in both AMG- and L-NAME treated graft but CD4+ and CD8+ cells were not. pimagedine 90-93 integrin subunit alpha M Homo sapiens 17-22 14503886-10 2003 We hypothesize that, even in the presence of AMG, a nonnegligible proportion of (*)OH radicals remained able to initiate oxidation of the LDL protein moiety, leading to apoB carbonylation. pimagedine 45-48 apolipoprotein B Homo sapiens 169-173 12911660-5 2003 The effect on luminal pH by iNOS activity was assessed using aminoguanidine, a potent iNOS inhibitor, and iNOS gene deficient (iNOS-/-) mice. pimagedine 61-75 nitric oxide synthase 2, inducible Mus musculus 28-32 12885234-1 2003 To prepare weakly basic thrombin inhibitors with modified S1 anchoring groups, two series of compounds were synthesized by reaction of guanidine or aminoguanidine with acyl halides and N,N-disubstituted carbamoyl chlorides. pimagedine 148-162 coagulation factor II, thrombin Homo sapiens 24-32 14623177-0 2003 FK 506 and aminoguanidine suppress iNOS induction in orthotopic corneal allografts and prolong graft survival in mice. pimagedine 11-25 nitric oxide synthase 2, inducible Mus musculus 35-39 14623177-1 2003 The aim of this study was to compare the effectiveness of immunosuppressant FK 506 and the specific inhibitor of inducible nitric oxide synthase (iNOS) aminoguanidine (AG) in prevention of corneal graft rejection and to investigate the iNOS expression in the rejection process. pimagedine 152-166 nitric oxide synthase 2, inducible Mus musculus 113-144 14623177-1 2003 The aim of this study was to compare the effectiveness of immunosuppressant FK 506 and the specific inhibitor of inducible nitric oxide synthase (iNOS) aminoguanidine (AG) in prevention of corneal graft rejection and to investigate the iNOS expression in the rejection process. pimagedine 152-166 nitric oxide synthase 2, inducible Mus musculus 146-150 12927381-2 2003 We have previously shown that pretreatment of BN rats with aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and misoprostol, a prostaglandin E (PGE) analog, completely prevented the development of D-penicillamine-induced autoimmunity. pimagedine 59-73 nitric oxide synthase 2 Rattus norvegicus 78-109 12927381-2 2003 We have previously shown that pretreatment of BN rats with aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and misoprostol, a prostaglandin E (PGE) analog, completely prevented the development of D-penicillamine-induced autoimmunity. pimagedine 59-73 nitric oxide synthase 2 Rattus norvegicus 111-115 12911628-4 2003 Aminoguanidine, an inhibitor of inducible nitric oxide synthase (iNOS), or SB203580, an inhibitor of p38 mitogen-activated protein kinase, prevented dopaminergic cell loss as well as nitrite production. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 32-63 12911628-4 2003 Aminoguanidine, an inhibitor of inducible nitric oxide synthase (iNOS), or SB203580, an inhibitor of p38 mitogen-activated protein kinase, prevented dopaminergic cell loss as well as nitrite production. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 65-69 12969769-6 2003 This impairment was restored by dexamethasone, the iNOS inhibitor aminoguanidine and partially by brain-derived neurotrophic factor (BDNF). pimagedine 66-80 nitric oxide synthase 2 Rattus norvegicus 51-55 12937831-6 2003 Aminoguanidine (AG), a selective inhibitor of inducible nitric oxide synthase (iNOS), inhibited LPS-induced increase in fluorescent intensity of NT in BPAECs. pimagedine 0-14 nitric oxide synthase 2 Bos taurus 46-77 12937831-6 2003 Aminoguanidine (AG), a selective inhibitor of inducible nitric oxide synthase (iNOS), inhibited LPS-induced increase in fluorescent intensity of NT in BPAECs. pimagedine 0-14 nitric oxide synthase 2 Bos taurus 79-83 12885234-3 2003 These molecules typically showed inhibition constants in the range of 150-425 nM against thrombin and 360-965 nM against trypsin, even though some bulky derivatives, such as N,N-diphenylcarbamoylguanidine/aminoguanidine and their congeners, showed much stronger thrombin inhibitory activity, with inhibition constants in the range of 24-42 nM. pimagedine 205-219 coagulation factor II, thrombin Homo sapiens 89-97 12832291-5 2003 Endostatin expression and release was reduced by the nitric oxide synthase inhibitors aminoguanidine and L-NAME and induced by the NO synthase-independent NO donors sodium nitroprusside (SNP) and spermine-NONO-ate. pimagedine 86-100 collagen type XVIII alpha 1 chain Homo sapiens 0-10 12899666-17 2003 Metoprine (inhibitor of histamine N-methyl transferase) did not affect the microdialysate histamine concentration, while aminoguanidine (inhibitor of diamine oxidase) raised both basal and gastrin-stimulated histamine concentrations. pimagedine 121-135 amine oxidase, copper containing 1 Rattus norvegicus 150-165 12899666-17 2003 Metoprine (inhibitor of histamine N-methyl transferase) did not affect the microdialysate histamine concentration, while aminoguanidine (inhibitor of diamine oxidase) raised both basal and gastrin-stimulated histamine concentrations. pimagedine 121-135 gastrin Rattus norvegicus 189-196 12805564-9 2003 After 3 days of ischemia, MMP-2 activity and MMP-3 and MMP-13 protein levels were increased in untreated and aminoguanidine-treated diabetic mice when compared with controls (P < 0.05). pimagedine 109-123 matrix metallopeptidase 2 Mus musculus 26-31 12805564-9 2003 After 3 days of ischemia, MMP-2 activity and MMP-3 and MMP-13 protein levels were increased in untreated and aminoguanidine-treated diabetic mice when compared with controls (P < 0.05). pimagedine 109-123 matrix metallopeptidase 3 Mus musculus 45-50 12805564-9 2003 After 3 days of ischemia, MMP-2 activity and MMP-3 and MMP-13 protein levels were increased in untreated and aminoguanidine-treated diabetic mice when compared with controls (P < 0.05). pimagedine 109-123 matrix metallopeptidase 13 Mus musculus 55-61 12763045-7 2003 The ARE from the mouse GST A1 promoter was activated about 9-fold by spermine and 5-fold by spermidine treatment, but could be inhibited by the amine oxidase inhibitor, aminoguanidine, suggesting that acrolein or hydrogen peroxide generated from polyamines by serum amine oxidase may be mediators for phase 2 enzyme induction. pimagedine 169-183 glutathione S-transferase, alpha 1 (Ya) Mus musculus 23-29 12761099-6 2003 The promoters were upregulated in activated RAW264.7 macrophage-like cells, which produce NO via the inducible nitric oxide synthase (iNOS), and the induction was inhibited by aminoguanidine, an inhibitor of iNOS. pimagedine 176-190 nitric oxide synthase 2, inducible Mus musculus 101-132 12773701-4 2003 However, the iNOS inhibitor aminoguanidine (AG) decreases the VEGF expression induced by LPS/IFN-gamma, indicating an important role for NO. pimagedine 28-42 nitric oxide synthase 2, inducible Mus musculus 13-17 12773701-4 2003 However, the iNOS inhibitor aminoguanidine (AG) decreases the VEGF expression induced by LPS/IFN-gamma, indicating an important role for NO. pimagedine 28-42 vascular endothelial growth factor A Mus musculus 62-66 12773701-4 2003 However, the iNOS inhibitor aminoguanidine (AG) decreases the VEGF expression induced by LPS/IFN-gamma, indicating an important role for NO. pimagedine 28-42 toll-like receptor 4 Mus musculus 89-92 12773701-4 2003 However, the iNOS inhibitor aminoguanidine (AG) decreases the VEGF expression induced by LPS/IFN-gamma, indicating an important role for NO. pimagedine 28-42 interferon gamma Mus musculus 93-102 12852838-8 2003 (3) The above changes were reduced by aminoguanidine (AG), an inhibitor of nitric oxide synthase (iNOS). pimagedine 38-52 nitric oxide synthase 2 Rattus norvegicus 98-102 12761099-6 2003 The promoters were upregulated in activated RAW264.7 macrophage-like cells, which produce NO via the inducible nitric oxide synthase (iNOS), and the induction was inhibited by aminoguanidine, an inhibitor of iNOS. pimagedine 176-190 nitric oxide synthase 2, inducible Mus musculus 134-138 12761099-6 2003 The promoters were upregulated in activated RAW264.7 macrophage-like cells, which produce NO via the inducible nitric oxide synthase (iNOS), and the induction was inhibited by aminoguanidine, an inhibitor of iNOS. pimagedine 176-190 nitric oxide synthase 2, inducible Mus musculus 208-212 12800248-3 2003 The animals were randomly divided into 3 groups: sham operation (Sham), 2 h ischemia followed by 2 h reperfusion (IR) and IR pretreated with aminoguanidine (AG) - an inhibitor of inducible NO synthase (iNOS) 15 minutes before reperfusion (IR+AG). pimagedine 141-155 nitric oxide synthase 2 Rattus norvegicus 179-200 12726728-4 2003 Animals treated with aminoguanidine (AG), an iNOS inhibitor, showed a dose-dependent increase in vaginal pathology after viral infection compared to controls. pimagedine 21-35 nitric oxide synthase 2, inducible Mus musculus 45-49 12668073-2 2003 CEL was generated by incubating bovine serum albumin (BSA) with glucose, a reaction inhibited by aminoguanidine, but enhanced by phosphate. pimagedine 97-111 albumin Homo sapiens 39-52 12713868-14 2003 CONCLUSIONS: Administration of the iNOS inhibitor AMG prior to insult reduces the severity of damage and improves mortality. pimagedine 50-53 nitric oxide synthase 2 Rattus norvegicus 35-39 12826063-0 2003 Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding. pimagedine 52-66 nitric oxide synthase 3 Homo sapiens 70-103 12826063-0 2003 Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding. pimagedine 105-119 nitric oxide synthase 3 Homo sapiens 70-103 15139133-7 2003 RESULTS: Both Tangfukang and aminoguanidine significantly decreased the expression of AGEs, but Tangfukang was greatly superior to aminoguanidine in suppressing the expression of cytokine like ICAM-1, IL-1 beta, TNF-alpha and the ingredients of extracellular matrix like IV-C, FN. pimagedine 131-145 interleukin 1 beta Rattus norvegicus 201-210 12740598-8 2003 Daily treatment with the iNOS inhibitor aminoguanidine (AG) or the peroxynitrite scavenger uric acid (UA) prevented the tyrosine nitration of synaptophysin as well as the impairment of nicotine-evoked ACh release induced by Abeta. pimagedine 40-54 nitric oxide synthase 2 Rattus norvegicus 25-29 12629417-5 2003 They were given the iNOS inhibitor aminoguanidine in drinking water or unmodified water. pimagedine 35-49 nitric oxide synthase 2, inducible Mus musculus 20-24 12686132-12 2003 Aminoguanidine, which blocks advanced glycation and reduces nephropathy in animals, is in fact more potent at inhibiting SSAO than its effect on glycation. pimagedine 0-14 amine oxidase, copper containing 3 Mus musculus 121-125 12740598-8 2003 Daily treatment with the iNOS inhibitor aminoguanidine (AG) or the peroxynitrite scavenger uric acid (UA) prevented the tyrosine nitration of synaptophysin as well as the impairment of nicotine-evoked ACh release induced by Abeta. pimagedine 40-54 synaptophysin Rattus norvegicus 142-155 12841356-9 2003 FGF-2 glycated in the presence of 4 mmol/l aminosalicylic acid or aminoguanidine retained mitogenic activity compared to that glycated in their absence. pimagedine 66-80 fibroblast growth factor 2 Bos taurus 0-5 12740598-8 2003 Daily treatment with the iNOS inhibitor aminoguanidine (AG) or the peroxynitrite scavenger uric acid (UA) prevented the tyrosine nitration of synaptophysin as well as the impairment of nicotine-evoked ACh release induced by Abeta. pimagedine 40-54 amyloid beta precursor protein Rattus norvegicus 224-229 12579534-8 2003 Interestingly, administration of the NOS inhibitor aminoguanidine (AG) or N(G)-nitro-L-arginine methyl ester inhibited HO-1 expression. pimagedine 51-65 heme oxygenase 1 Rattus norvegicus 119-123 12623960-6 2003 In addition, microinjection bilaterally into the RVLM of a selective iNOS inhibitor, aminoguanidine (125 or 250 pmol), was discernibly less efficacious in unmasking hypertension, tachycardia, and the increase in sympathetic vasomotor tone in adult SHR. pimagedine 85-99 nitric oxide synthase 2 Rattus norvegicus 69-73 12704490-11 2003 This was inhibited by the iNOS inhibitor aminoguanidine. pimagedine 41-55 nitric oxide synthase 2 Canis lupus familiaris 26-30 12704490-14 2003 The functional aspect of this endothelial iNOS expression was reversible with aminoguanidine. pimagedine 78-92 nitric oxide synthase 2 Canis lupus familiaris 42-46 12444009-4 2003 CCK secretagogue-induced gastroprotection and hyperemia were negated by nonselective nitric oxide synthase (NOS) inhibition (N(G)-nitro-L-arginine methyl ester) but not by selective inducible NOS inhibition (aminoguanidine). pimagedine 208-222 cholecystokinin Rattus norvegicus 0-3 12590163-5 2003 Our results show that AGEs induce lipid peroxidation in a neuronal cell line in a dose-dependant manner, and that blocking the specific AGE-receptor RAGE, as well as using different antioxidants (alpha-lipoic acid, N-acetylcysteine, 17 beta-estradiol or aminoguanidine) can reduce the AGE-mediated formation of lipid peroxidation products. pimagedine 254-268 advanced glycosylation end-product specific receptor Homo sapiens 149-153 12571850-7 2003 Production of NO was blunted by the iNOS-specific inhibitors L-N(G)-nitroarginine methyl ester and aminoguanidine. pimagedine 99-113 nitric oxide synthase 2 Homo sapiens 36-40 12631075-7 2003 Aminoguanidine and N-acetyl-l-cysteine inhibited the MG-induced p38 MAPK activation, as well as apoptosis in rat mesangial cells, suggesting the involvement of oxidative stress in these phenomena. pimagedine 0-14 mitogen activated protein kinase 14 Rattus norvegicus 64-67 12696628-7 2003 Aminoguanidine, an inhibitor of NO synthase (NOS), reduced peroxynitrite formation and prevented apoptosis. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 32-43 12527112-5 2003 Agmatine modulation of ODC and SSAT activities is noticeably augmented by the inhibitor of its catabolism, aminoguanidine. pimagedine 107-121 ornithine decarboxylase, structural 1 Mus musculus 23-26 12623224-1 2003 The present study examined the effects of a selective inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG), on neuronal cell survival and post-traumatic recovery in rats following a lateral fluid percussive brain injury. pimagedine 104-118 nitric oxide synthase 2 Rattus norvegicus 54-85 12623224-1 2003 The present study examined the effects of a selective inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG), on neuronal cell survival and post-traumatic recovery in rats following a lateral fluid percussive brain injury. pimagedine 104-118 nitric oxide synthase 2 Rattus norvegicus 87-91 12661899-3 2003 Our objective was to characterize the molecular signaling events involving the pro-inflammatory mediators interleukin-6 (IL-6) and macrophage inflammatory protein (MIP-2) in the presence of aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) specific inhibitor, in lung tissue from GBS-treated young rats. pimagedine 190-204 interleukin 6 Rattus norvegicus 121-125 12661899-3 2003 Our objective was to characterize the molecular signaling events involving the pro-inflammatory mediators interleukin-6 (IL-6) and macrophage inflammatory protein (MIP-2) in the presence of aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) specific inhibitor, in lung tissue from GBS-treated young rats. pimagedine 190-204 C-X-C motif chemokine ligand 2 Rattus norvegicus 164-169 12622700-9 2003 Aminoguanidine, an inhibitor of iNOS activity, totally reversed the LPS-induced embryonic resorption. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 32-36 12436490-3 2003 When specific inhibition of iNOS was achieved by intraperitoneal administration of amino guanidine (AG), significantly greater mortality was observed in treated animals (70% vs. 40%), together with similar infective titers ( approximately 10(7) PFU/g) but lower astrocytosis, as shown by glial fibrillary acidic (GFAP) labeling. pimagedine 83-98 nitric oxide synthase 2 Homo sapiens 28-32 12436490-3 2003 When specific inhibition of iNOS was achieved by intraperitoneal administration of amino guanidine (AG), significantly greater mortality was observed in treated animals (70% vs. 40%), together with similar infective titers ( approximately 10(7) PFU/g) but lower astrocytosis, as shown by glial fibrillary acidic (GFAP) labeling. pimagedine 83-98 glial fibrillary acidic protein Homo sapiens 313-317 12514219-4 2003 Inhibition of iNOS by aminoguanidine prevented ischemia-induced neurogenesis in the dentate gyrus. pimagedine 22-36 nitric oxide synthase 2 Homo sapiens 14-18 12446618-0 2002 Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. pimagedine 89-103 cellular communication network factor 2 Rattus norvegicus 6-37 14588184-9 2003 The effect of oestradiol was abolished by pre-incubation with 500 micro M aminoguanidine, an iNOS inhibitor, or by coadministration of oestradiol with 3 mg kg(-1) dexamethasone, but the effect of progesterone was not affected by these treatments. pimagedine 74-88 nitric oxide synthase 2 Rattus norvegicus 93-97 14737939-2 2003 In this study, L-NNA, a non-selective NO-synthase inhibitor, and aminoguanidine, a relative inhibitor of inducible NO-synthase (iNOS), were applied prior to short ischemia (occlusion of celiac artery 1-5 times for 5 min) followed by a subsequent exposure to 0.5 h of ischemia and 3 h of reperfusion (I/R). pimagedine 65-79 nitric oxide synthase 2 Rattus norvegicus 105-126 14737939-2 2003 In this study, L-NNA, a non-selective NO-synthase inhibitor, and aminoguanidine, a relative inhibitor of inducible NO-synthase (iNOS), were applied prior to short ischemia (occlusion of celiac artery 1-5 times for 5 min) followed by a subsequent exposure to 0.5 h of ischemia and 3 h of reperfusion (I/R). pimagedine 65-79 nitric oxide synthase 2 Rattus norvegicus 128-132 12446618-1 2002 The aim of this study was to determine whether aminoguanidine (AG), an inhibitor of advanced glycation, prevents expression of the profibrotic cytokine, connective tissue growth factor (CTGF), as well as accumulation of the previously reported CTGF-dependent matrix protein, fibronectin, in a model of experimental diabetic nephropathy. pimagedine 47-61 cellular communication network factor 2 Rattus norvegicus 153-184 12446618-1 2002 The aim of this study was to determine whether aminoguanidine (AG), an inhibitor of advanced glycation, prevents expression of the profibrotic cytokine, connective tissue growth factor (CTGF), as well as accumulation of the previously reported CTGF-dependent matrix protein, fibronectin, in a model of experimental diabetic nephropathy. pimagedine 47-61 cellular communication network factor 2 Rattus norvegicus 186-190 12446618-1 2002 The aim of this study was to determine whether aminoguanidine (AG), an inhibitor of advanced glycation, prevents expression of the profibrotic cytokine, connective tissue growth factor (CTGF), as well as accumulation of the previously reported CTGF-dependent matrix protein, fibronectin, in a model of experimental diabetic nephropathy. pimagedine 47-61 cellular communication network factor 2 Rattus norvegicus 244-248 12446618-1 2002 The aim of this study was to determine whether aminoguanidine (AG), an inhibitor of advanced glycation, prevents expression of the profibrotic cytokine, connective tissue growth factor (CTGF), as well as accumulation of the previously reported CTGF-dependent matrix protein, fibronectin, in a model of experimental diabetic nephropathy. pimagedine 47-61 fibronectin 1 Rattus norvegicus 275-286 12459165-7 2002 However, blockage of nitric oxide production by treatment with aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), led to a significant rise in RT activity. pimagedine 63-77 nitric oxide synthase 2 Homo sapiens 106-137 12462564-5 2002 Aminoguanidine, a selective iNOS inhibitor, attenuated LPS-induced hepatic injury and hypotension, but did not prevent gut I/R-induced hepatic injury. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 28-32 12459165-7 2002 However, blockage of nitric oxide production by treatment with aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), led to a significant rise in RT activity. pimagedine 63-77 nitric oxide synthase 2 Homo sapiens 139-143 12459165-8 2002 This rise in RT activity was partially reversed in aminoguanidine treated cultures by L-arginine, the normal substrate for iNOS. pimagedine 51-65 nitric oxide synthase 2 Homo sapiens 123-127 12237746-8 2002 In mice treated with LPS significantly increased levels of plasma nitrite and serum TNF-alpha were observed, changes inhibited by aminoguanidine [an inhibitor of inducible NO synthase (iNOS)] and pentoxifylline (an inhibitor of tumor necrosis factor-alpha formation), respectively. pimagedine 130-144 tumor necrosis factor Mus musculus 84-93 12441138-4 2002 Aminoguanidine, an inhibitor of amine oxidases, inhibits the cleavage of PARP and cell death, whereas the antioxidant BHA inhibits PARP cleavage but not cell death. pimagedine 0-14 poly (ADP-ribose) polymerase family, member 1 Mus musculus 73-77 12433208-4 2002 In brain, NOx was increased by about 40% vs. normal and it was significantly inhibited by aminoguanidine, selective iNOS inhibitor. pimagedine 90-104 nitric oxide synthase 2 Rattus norvegicus 116-120 12381419-8 2002 Deformability was unchanged after incubation with specific iNOS inhibitor aminoguanidine, but decreased after incubation with N-formyl-methionyl-leucyl-phenyl-alanine. pimagedine 74-88 nitric oxide synthase 2 Rattus norvegicus 59-63 12381419-10 2002 iNOS was detectable in the PMNs, and the deformability further decreased after incubation with aminoguanidine. pimagedine 95-109 nitric oxide synthase 2 Rattus norvegicus 0-4 12377946-6 2002 Treatment of SGVHD animals with the iNOS inhibitor aminoguanidine (AG) reversed the pathology associated with this disease. pimagedine 51-65 nitric oxide synthase 2, inducible Mus musculus 36-40 12237746-8 2002 In mice treated with LPS significantly increased levels of plasma nitrite and serum TNF-alpha were observed, changes inhibited by aminoguanidine [an inhibitor of inducible NO synthase (iNOS)] and pentoxifylline (an inhibitor of tumor necrosis factor-alpha formation), respectively. pimagedine 130-144 nitric oxide synthase 2, inducible Mus musculus 162-183 12237746-8 2002 In mice treated with LPS significantly increased levels of plasma nitrite and serum TNF-alpha were observed, changes inhibited by aminoguanidine [an inhibitor of inducible NO synthase (iNOS)] and pentoxifylline (an inhibitor of tumor necrosis factor-alpha formation), respectively. pimagedine 130-144 nitric oxide synthase 2, inducible Mus musculus 185-189 12237746-8 2002 In mice treated with LPS significantly increased levels of plasma nitrite and serum TNF-alpha were observed, changes inhibited by aminoguanidine [an inhibitor of inducible NO synthase (iNOS)] and pentoxifylline (an inhibitor of tumor necrosis factor-alpha formation), respectively. pimagedine 130-144 tumor necrosis factor Mus musculus 228-255 12191972-0 2002 Evidence for the existence of two distinct functions for the inducible NO synthase in the rat kidney: effect of aminoguanidine in rats with 5/6 ablation. pimagedine 112-126 nitric oxide synthase 2 Rattus norvegicus 61-82 12397395-7 2002 Blockade of histamine N-methyltransferase by amodiaquin (100 microM) abolished catabolism completely, whereas blockade of diamine oxidase by aminoguanidine (100 microM) was less effective. pimagedine 141-155 amine oxidase copper containing 1 Sus scrofa 122-137 12175893-7 2002 Treatment with iNOS inhibitor aminoguanidine (100 mg.kg(-1), i.p.) pimagedine 30-44 nitric oxide synthase 2, inducible Mus musculus 15-19 12067760-4 2002 Posttransplantation, aminoguanidine (AG)-treated rat received continuous intravenous infusion of AG, an inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 21-35 nitric oxide synthase 2 Rattus norvegicus 117-148 12489640-5 2002 This LPS-induced decrement did not occur when aminoguanidine (AG), an inhibitor of iNOS, was co-administered with LPS. pimagedine 46-60 nitric oxide synthase 2 Rattus norvegicus 83-87 12067760-4 2002 Posttransplantation, aminoguanidine (AG)-treated rat received continuous intravenous infusion of AG, an inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 21-35 nitric oxide synthase 2 Rattus norvegicus 150-154 12242458-6 2002 RESULTS: Both MDL-72974A, a selective mechanism-based semicarbazide-sensitive amine oxidase inhibitor and aminoguanidine effectively inhibited aorta semicarbazide-sensitive amine oxidase activity, and caused a substantial increase in urinary methylamine, and a decrease in formaldehyde and methylgloxal levels. pimagedine 106-120 amine oxidase, copper containing 3 Mus musculus 149-186 12297111-3 2002 The inhibitors of NO synthase, aminoguanidine and L-NMMA, but not L-NMMA inactive counterpart D-NMMA, mimicked the effects of A77 1726 and MPA on IL-6 generation in L929 fibroblasts. pimagedine 31-45 interleukin 6 Mus musculus 146-150 12215601-9 2002 Responses to both nitroprusside and bradykinin were improved by aminoguanidine (300 micromol/L), an inhibitor of iNOS. pimagedine 64-78 kininogen 1 Homo sapiens 36-46 12215601-9 2002 Responses to both nitroprusside and bradykinin were improved by aminoguanidine (300 micromol/L), an inhibitor of iNOS. pimagedine 64-78 nitric oxide synthase 2 Homo sapiens 113-117 12269697-0 2002 Aminoguanidine, an inducible nitric oxide synthase inhibitor, plus N-acetylcysteine treatment reduce the lipopolysaccharide-augmented hepatotoxicity in rats with cirrhosis. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 19-50 12269697-4 2002 However, aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) inhibitor, plus N-acetylcysteine (NAC) treatment reduced the LPS-augmented hepatotoxicity in rats with cirrhosis without making any changes in oxidative stress in the liver. pimagedine 9-23 nitric oxide synthase 2 Rattus norvegicus 33-64 12269697-4 2002 However, aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) inhibitor, plus N-acetylcysteine (NAC) treatment reduced the LPS-augmented hepatotoxicity in rats with cirrhosis without making any changes in oxidative stress in the liver. pimagedine 9-23 nitric oxide synthase 2 Rattus norvegicus 66-70 12072686-6 2002 When lipopolysaccharide was combined with central administration of aminoguanidine, an inducible nitric oxide synthase inhibitor, we observed a sustained increase in plasma vasopressin concentration and in the maintenance of blood pressure at 4 and 6 hrs after lipopolysaccharide treatment compared with rats treated with lipopolysaccharide alone. pimagedine 68-82 nitric oxide synthase 2 Rattus norvegicus 87-118 12105371-13 2002 The iNOS inhibitor aminoguanidine (200 mg/kg IP) eliminated the infarct-sparing effect of AP. pimagedine 19-33 nitric oxide synthase 2 Rattus norvegicus 4-8 12003803-8 2002 Cardioprotective effects of resveratrol was abolished when the wild-type mouse hearts were simultaneously perfused with aminoguanidine, an iNOS inhibitor. pimagedine 120-134 nitric oxide synthase 2, inducible Mus musculus 139-143 12393931-6 2002 Anti-AGE-R1,2,3 and -RAGE IgG each inhibited cell-associated (125) I-dAGE by approximately 30-55%; GSH/GPx were effectively blocked by N-acetyl-cysteine (NAC, 800 uM, p < 0.01) and aminoguanidine-HCl (AG, 100 uM, p < 0.01). pimagedine 184-202 long intergenic non-protein coding RNA 914 Homo sapiens 21-25 12072156-6 2002 The latter was abolished by the iNOS-inhibitor aminoguanidine. pimagedine 47-61 nitric oxide synthase 2, inducible Mus musculus 32-36 12072686-6 2002 When lipopolysaccharide was combined with central administration of aminoguanidine, an inducible nitric oxide synthase inhibitor, we observed a sustained increase in plasma vasopressin concentration and in the maintenance of blood pressure at 4 and 6 hrs after lipopolysaccharide treatment compared with rats treated with lipopolysaccharide alone. pimagedine 68-82 arginine vasopressin Rattus norvegicus 173-184 12054156-7 2002 Conversely, the responses in iNOS+/+ mice were inhibited by treatment with an NOS inhibitor aminoguanidine (AG). pimagedine 92-106 nitric oxide synthase 2, inducible Mus musculus 29-33 12016107-9 2002 Inhibition of the increased iNOS activity with aminoguanidine, in vitro, partially restored cNOS activity following acute (6-12 hours) but not chronic sepsis (24-48 hours post-CLP). pimagedine 47-61 nitric oxide synthase 2 Rattus norvegicus 28-32 12050186-7 2002 Inhibition of NOSII with aminoguanidine reduced COX-2 mRNA and protein expression as well as PGE2 production by activated macrophages from endotoxemic, but not control animals. pimagedine 25-39 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 48-53 12016107-9 2002 Inhibition of the increased iNOS activity with aminoguanidine, in vitro, partially restored cNOS activity following acute (6-12 hours) but not chronic sepsis (24-48 hours post-CLP). pimagedine 47-61 nitric oxide synthase 3 Rattus norvegicus 92-96 12019311-11 2002 Aminoguanidine, an iNOS inhibitor, also attenuated infarct size and NO in ischemic and inflammation models. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 19-23 11978653-8 2002 Aminoguanidine, an inhibitor of AGE formation, partially prevented the EGFR dysfunction induced by GO and MGO. pimagedine 0-14 epidermal growth factor receptor Homo sapiens 71-75 11997020-5 2002 The putative lipid peroxide-derived aldehyde scavenger, aminoguanidine, however, inhibited Abeta-oxidised lipoprotein-potentiated polymerisation, but in a manner consistent with an antioxidant action for the drug. pimagedine 56-70 amyloid beta precursor protein Homo sapiens 91-96 12062760-4 2002 Aminoguanidine, an inducible NO synthase (iNOS) inhibitor, significantly ameliorated the post-ischemic cochlear dysfunction induced by 60 min ischemia. pimagedine 0-14 nitric oxide synthase, inducible Cavia porcellus 19-40 11994544-7 2002 Combined treatment with aminoguanidine and onapristone for 3 days led to a transient suppression of Erk1/2 and abolished Cox2 expression. pimagedine 24-38 mitogen activated protein kinase 3 Rattus norvegicus 100-106 11994544-7 2002 Combined treatment with aminoguanidine and onapristone for 3 days led to a transient suppression of Erk1/2 and abolished Cox2 expression. pimagedine 24-38 cytochrome c oxidase II, mitochondrial Rattus norvegicus 121-125 11971007-7 2002 TNF production by B10.A macrophages appeared to be suppressed by NO, because the addition of aminoguanidine sulfate, an inducible NO synthase (NOS2) inhibitor, resulted in TNF production. pimagedine 93-115 tumor necrosis factor Mus musculus 0-3 11971007-7 2002 TNF production by B10.A macrophages appeared to be suppressed by NO, because the addition of aminoguanidine sulfate, an inducible NO synthase (NOS2) inhibitor, resulted in TNF production. pimagedine 93-115 nitric oxide synthase 2, inducible Mus musculus 120-141 11971007-7 2002 TNF production by B10.A macrophages appeared to be suppressed by NO, because the addition of aminoguanidine sulfate, an inducible NO synthase (NOS2) inhibitor, resulted in TNF production. pimagedine 93-115 nitric oxide synthase 2, inducible Mus musculus 143-147 11971007-7 2002 TNF production by B10.A macrophages appeared to be suppressed by NO, because the addition of aminoguanidine sulfate, an inducible NO synthase (NOS2) inhibitor, resulted in TNF production. pimagedine 93-115 tumor necrosis factor Mus musculus 172-175 12042098-11 2002 To assess the functional consequences of iNOS inhibition, aminoguanidine treatment was initiated 5 min after SCI and rats tested using the BBB open field locomotor score. pimagedine 58-72 nitric oxide synthase 2 Rattus norvegicus 41-45 12022762-1 2002 This study evaluates the effect of aminoguanidine, a preferential inhibitor of inducible nitric oxide synthase (iNOS), on the prevention of cardiac depression in acute endotoxemia. pimagedine 35-49 nitric oxide synthase 2 Rattus norvegicus 79-110 12022762-1 2002 This study evaluates the effect of aminoguanidine, a preferential inhibitor of inducible nitric oxide synthase (iNOS), on the prevention of cardiac depression in acute endotoxemia. pimagedine 35-49 nitric oxide synthase 2 Rattus norvegicus 112-116 12062760-4 2002 Aminoguanidine, an inducible NO synthase (iNOS) inhibitor, significantly ameliorated the post-ischemic cochlear dysfunction induced by 60 min ischemia. pimagedine 0-14 nitric oxide synthase, inducible Cavia porcellus 42-46 11911836-3 2002 This compound decreased inducible NO synthase (iNOS) activity, with the inhibitory effect at a concentration of 25 microM being equal to that of the known iNOS inhibitor aminoguanidine at 50 microM. pimagedine 170-184 nitric oxide synthase 2 Homo sapiens 155-159 11869170-6 2002 Addition of the iNOS inhibitor aminoguanidine resulted in full recovery of the responses to noradrenaline in superior mesenteric, renal and hepatic arteries. pimagedine 31-45 nitric oxide synthase 2 Rattus norvegicus 16-20 11890976-3 2002 Colonic temperature (Tc) was measured in unanesthetized rats before and after treatment with the more selective nNOS inhibitor 7-nitroindazole or with the selective iNOS inhibitor aminoguanidine (AG) under unrestrained or restrained conditions. pimagedine 180-194 nitric oxide synthase 2 Rattus norvegicus 165-169 11870630-6 2002 Treatment of Ag-stimulated cultures with aminoguanidine (AMG), an inhibitor of inducible nitric oxide synthase, rescued the CD4(+) T cells from apoptosis and reversed the proliferative defect. pimagedine 41-55 CD4 antigen Mus musculus 124-127 11870630-6 2002 Treatment of Ag-stimulated cultures with aminoguanidine (AMG), an inhibitor of inducible nitric oxide synthase, rescued the CD4(+) T cells from apoptosis and reversed the proliferative defect. pimagedine 57-60 CD4 antigen Mus musculus 124-127 11890907-7 2002 Histamine dose-dependently induced the contraction of sections of the guinea-pig small intestine, and the pretreatment of the tissue section with aminoguanidine (100 microM), a diamine oxidase inhibitor, but not with S-[4-(N,N-dimethylamino)butyl]isothiourea (100 microM), an inhibitor of histamine N-methyltransferase, shifted the dose-response curve of histamine-induced contraction to lower concentrations. pimagedine 146-160 histamine N-methyltransferase Cavia porcellus 289-318 11788371-7 2002 Aminoguanidine completely blocked the LPS-elevated hepatic glucose output and also inhibited LPS-induced increases in hepatic glycogen phosphorylase activities and phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression, key enzymes for glycogenolysis and gluconeogenesis, respectively. pimagedine 0-14 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 164-197 11788371-7 2002 Aminoguanidine completely blocked the LPS-elevated hepatic glucose output and also inhibited LPS-induced increases in hepatic glycogen phosphorylase activities and phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression, key enzymes for glycogenolysis and gluconeogenesis, respectively. pimagedine 0-14 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 199-204 11788371-8 2002 Thus, these data demonstrate an important role for iNOS in LPS-induced insulin resistance, evidenced by the attenuation of LPS-induced hyperglycemia and reversal of increased hepatic glucose output by aminoguanidine. pimagedine 201-215 nitric oxide synthase 2 Rattus norvegicus 51-55 11788371-9 2002 The protective effect of aminoguanidine on insulin resistance is probably by attenuation of hepatic glucose output via its inhibition of key enzymes for glycogenolysis and gluconeogenesis, including glycogen phosphorylase and PEPCK. pimagedine 25-39 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 226-231 11911836-3 2002 This compound decreased inducible NO synthase (iNOS) activity, with the inhibitory effect at a concentration of 25 microM being equal to that of the known iNOS inhibitor aminoguanidine at 50 microM. pimagedine 170-184 nitric oxide synthase 2 Homo sapiens 24-45 11911836-3 2002 This compound decreased inducible NO synthase (iNOS) activity, with the inhibitory effect at a concentration of 25 microM being equal to that of the known iNOS inhibitor aminoguanidine at 50 microM. pimagedine 170-184 nitric oxide synthase 2 Homo sapiens 47-51 11890907-7 2002 Histamine dose-dependently induced the contraction of sections of the guinea-pig small intestine, and the pretreatment of the tissue section with aminoguanidine (100 microM), a diamine oxidase inhibitor, but not with S-[4-(N,N-dimethylamino)butyl]isothiourea (100 microM), an inhibitor of histamine N-methyltransferase, shifted the dose-response curve of histamine-induced contraction to lower concentrations. pimagedine 146-160 amiloride-sensitive amine oxidase [copper-containing] Cavia porcellus 177-192 11786263-1 2002 Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 119-123 12172903-11 2002 The inducible nitric oxide synthase inhibitor, aminoguanidine, significantly attenuated the increases in plasma NO metabolites and tissue MPO content as well as lung injuries. pimagedine 47-61 myeloperoxidase Mus musculus 138-141 12379813-7 2002 The intestinal lesions induced by indomethacin were prevented by either supplementation with dmPGE(2), inhibition of bacterial invasion with ampicillin or inhibition of iNOS activity with aminoguanidine, while the hypermotility response was prevented by dmPGE(2) only. pimagedine 188-202 nitric oxide synthase 2 Rattus norvegicus 169-173 11744809-12 2002 Aminoguanidine reversed this high glucose-induced fibronectin production at dose inhibiting iNOS mRNA expression. pimagedine 0-14 fibronectin 1 Rattus norvegicus 50-61 11773821-2 2002 An important effect of the neuroprotective substance aminoguanidine (AG) is the inhibition of inducible nitric oxide synthase (iNOS), a perpetrator of focal ischemic damage. pimagedine 53-67 nitric oxide synthase, inducible Oryctolagus cuniculus 94-125 11773821-2 2002 An important effect of the neuroprotective substance aminoguanidine (AG) is the inhibition of inducible nitric oxide synthase (iNOS), a perpetrator of focal ischemic damage. pimagedine 53-67 nitric oxide synthase, inducible Oryctolagus cuniculus 127-131 11744809-12 2002 Aminoguanidine reversed this high glucose-induced fibronectin production at dose inhibiting iNOS mRNA expression. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 92-96 11739313-6 2001 When NO production by iNOS was inhibited by aminoguanidine (1 mmol/L), there was a further increase in the forskolin-induced CaSpF in LPS myocytes (to levels similar to the forskolin-stimulated CaSpF in normal myocytes). pimagedine 44-58 nitric oxide synthase 2 Homo sapiens 22-26 11562408-9 2001 Aminoguanidine attenuated not only the overexpression of TGF-beta1 and PDGF-B but also reduced type IV collagen deposition in diabetic rats (P < 0.05). pimagedine 0-14 transforming growth factor, beta 1 Rattus norvegicus 57-66 11855796-7 2001 In diabetic rats, elevations in retinal TBARS, PKC and NO were observed at 2 months of diabetes, and administration of N-acetyl cysteine, LY333531 or aminoguanidine prevented diabetes-induced elevation in retinal TBARS and NO levels, and PKC activity. pimagedine 150-164 protein kinase C, gamma Rattus norvegicus 47-57 11855796-7 2001 In diabetic rats, elevations in retinal TBARS, PKC and NO were observed at 2 months of diabetes, and administration of N-acetyl cysteine, LY333531 or aminoguanidine prevented diabetes-induced elevation in retinal TBARS and NO levels, and PKC activity. pimagedine 150-164 protein kinase C, gamma Rattus norvegicus 47-50 11731407-2 2001 Administration of the iNOS inhibitor aminoguanidine (1.5 g/liter) in drinking water or an L-arginine-deficient diet to Apc(Min/+) mice resulted in a significant decrease in adenoma development in the small but not the large intestine. pimagedine 37-51 nitric oxide synthase 2, inducible Mus musculus 22-26 11574821-9 2001 Pretreatment with an iNOS inhibitor, aminoguanidine (AG, 50 mg/kg), reversed HCl-induced hypotension without a change in blood pH. pimagedine 37-51 nitric oxide synthase 2 Rattus norvegicus 21-25 11870678-6 2001 Nonlinear least-squares regression yielded the following Michaelis--Menten and diffusional (k(ns)) parameters for synaptosomal [(14)C]aminoguanidine uptake: V(max)=118.50 +/- 28.77 pmol x mg protein(-1)/3 min; K(m)=58.34 +/- 8.33 muM; k(ns)=0.15 +/- 0.029 pmol x mg protein(-1)/3 min/muM; mean +/- SEM; n=3 concentration profiles). pimagedine 133-148 latexin Homo sapiens 230-233 11870678-6 2001 Nonlinear least-squares regression yielded the following Michaelis--Menten and diffusional (k(ns)) parameters for synaptosomal [(14)C]aminoguanidine uptake: V(max)=118.50 +/- 28.77 pmol x mg protein(-1)/3 min; K(m)=58.34 +/- 8.33 muM; k(ns)=0.15 +/- 0.029 pmol x mg protein(-1)/3 min/muM; mean +/- SEM; n=3 concentration profiles). pimagedine 133-148 latexin Homo sapiens 284-287 11852433-1 2001 PURPOSE: Our previous results showed that the oral administration of aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS), strongly suppresses lens opacification in Shumiya cataract rat (SCR). pimagedine 69-83 nitric oxide synthase 2 Rattus norvegicus 106-137 11852433-1 2001 PURPOSE: Our previous results showed that the oral administration of aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS), strongly suppresses lens opacification in Shumiya cataract rat (SCR). pimagedine 69-83 nitric oxide synthase 2 Rattus norvegicus 139-143 11564815-6 2001 The NOS2 inhibitor aminoguanidine (50 and 100 mg/kg i.p.) pimagedine 19-33 nitric oxide synthase 2 Rattus norvegicus 4-8 11590196-7 2001 Inhibition of nitric oxide synthase (NOS) isoforms with L-NAME or aminoguanidine blocked time-dependent increases in HIV gene expression in activated macrophages cultured ex vivo. pimagedine 66-80 nitric oxide synthase 1, neuronal Mus musculus 14-35 11584082-7 2001 The RA + LPS-mediated increase in PGE(2) was significantly attenuated (97%) by aminoguanidine (AG), a relatively specific inhibitor of the inducible nitric oxide synthase (NOS2), consistent with the previously reported synergistic effect of RA and LPS on NOS2 expression and activity. pimagedine 79-93 nitric oxide synthase 2 Rattus norvegicus 172-176 11584082-7 2001 The RA + LPS-mediated increase in PGE(2) was significantly attenuated (97%) by aminoguanidine (AG), a relatively specific inhibitor of the inducible nitric oxide synthase (NOS2), consistent with the previously reported synergistic effect of RA and LPS on NOS2 expression and activity. pimagedine 79-93 nitric oxide synthase 2 Rattus norvegicus 255-259 11562408-9 2001 Aminoguanidine attenuated not only the overexpression of TGF-beta1 and PDGF-B but also reduced type IV collagen deposition in diabetic rats (P < 0.05). pimagedine 0-14 platelet derived growth factor subunit B Rattus norvegicus 71-77 11562408-10 2001 TGF-beta1 and PDGF mRNA within glomeruli were also similarly increased with diabetes and attenuated with aminoguanidine. pimagedine 105-119 transforming growth factor, beta 1 Rattus norvegicus 0-9 11494409-6 2001 IFN-gamma + AMB treatment led to reduction of astrocyte mitochondrial respiration (measured by MTT assay) that has been completely reverted by selective iNOS inhibitor aminoguanidine. pimagedine 168-182 interferon gamma Rattus norvegicus 0-9 11535575-11 2001 Aminoguanidine, a selective inhibitor of iNOS, inhibited both the hypotension and the increases in plasma levels of NO(2)(-)/NO(3)(-) in this animal model. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 41-45 11494409-6 2001 IFN-gamma + AMB treatment led to reduction of astrocyte mitochondrial respiration (measured by MTT assay) that has been completely reverted by selective iNOS inhibitor aminoguanidine. pimagedine 168-182 nitric oxide synthase 2 Rattus norvegicus 153-157 11549347-5 2001 Aminoguanidine, an inhibitor of iNOS, reduced NO production by allograft myocytes, but was without effect on NO production by isograft myocytes. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 32-36 11697130-3 2001 This was suppressed by an inducible NO synthase (iNOS) inhibitor (aminoguanidine, N-nitro-L-arginine methylester hydrochloride) and arginase. pimagedine 66-80 nitric oxide synthase 2 Rattus norvegicus 26-47 11697130-3 2001 This was suppressed by an inducible NO synthase (iNOS) inhibitor (aminoguanidine, N-nitro-L-arginine methylester hydrochloride) and arginase. pimagedine 66-80 nitric oxide synthase 2 Rattus norvegicus 49-53 11517237-3 2001 In either case, activated glia caused 75-100% necrotic cell death within 48 hr, which was completely prevented by inhibitors of inducible nitric oxide synthase (iNOS) (aminoguanidine or 1400W). pimagedine 168-182 nitric oxide synthase 2 Homo sapiens 128-159 11517237-3 2001 In either case, activated glia caused 75-100% necrotic cell death within 48 hr, which was completely prevented by inhibitors of inducible nitric oxide synthase (iNOS) (aminoguanidine or 1400W). pimagedine 168-182 nitric oxide synthase 2 Homo sapiens 161-165 11498261-13 2001 By contrast, incubation with nonselective inhibitors of nitric oxide synthase (NOS), L-NAME and L-NNA, or aminoguanidine (AG), a selective inhibitor of inducible NOS (iNOS), blocked CRF release and, AG, its mRNA accumulation, stimulated by gp120, whereas selective inhibitors of endothelial and neuronal NOS had no effect. pimagedine 106-120 nitric oxide synthase 2 Rattus norvegicus 152-165 11522377-6 2001 Both NG-nitro-L-arginine-methyl ester and aminoguanidine, inhibitors of nitric oxide synthase, increased the AST level induced by abamectin. pimagedine 42-56 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 109-112 11498454-8 2001 Contraction and relaxation were improved in carotid arteries expressing iNOS by aminoguanidine and L-N-iminoethyl lysine, inhibitors of iNOS. pimagedine 80-94 nitric oxide synthase 2, inducible Mus musculus 72-76 11440919-3 2001 The administration of an iNOS synthesis inhibitor, aminoguanidine (AG), with LPS decreased NOS activity and PGE content. pimagedine 51-65 nitric oxide synthase 2 Homo sapiens 25-29 11466220-4 2001 Intraperitoneal injection of aminoguanidine (AMG) (400 mg/day), the inhibitor of iNOS, reduced NO production by 57.7% at 96 h of reperfusion. pimagedine 29-43 nitric oxide synthase 2 Rattus norvegicus 81-85 11466220-4 2001 Intraperitoneal injection of aminoguanidine (AMG) (400 mg/day), the inhibitor of iNOS, reduced NO production by 57.7% at 96 h of reperfusion. pimagedine 45-48 nitric oxide synthase 2 Rattus norvegicus 81-85 11580101-3 2001 Aminoguanidine, a selective inducible NO synthase inhibitor, abolished the inhibition of neutrophil migration and the increase in serum nitrate levels induced by a nonlethal dose of LPS. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 28-49 11426981-7 2001 Moreover, coincubation of OVCAR-3 and HOC-7 with the specific iNOS inhibitor aminoguanidine suppressed apoptosis induced by IFN-gamma, IL-1beta, and TNF-alpha. pimagedine 77-91 nitric oxide synthase 2 Homo sapiens 62-66 11445272-2 2001 In contrast, the pretreatment of the cerebellar slices with aminoguanidine (100 microM - 1 mM), an inhibitor of diamine oxidase, had no effect on histamine-induced phosphoinositide hydrolysis. pimagedine 60-74 amiloride-sensitive amine oxidase [copper-containing] Cavia porcellus 112-127 11500085-5 2001 Cell surface stimulation of CD23 expressed by astrocytes induced production of nitric oxide (NO) and IL-1beta which was inhibited by a specific inducible NO-synthase (iNOS) inhibitor (aminoguanidine), indicating the implication of this receptor in the astrocyte inflammatory reaction. pimagedine 184-198 Fc epsilon receptor II Homo sapiens 28-32 11500085-5 2001 Cell surface stimulation of CD23 expressed by astrocytes induced production of nitric oxide (NO) and IL-1beta which was inhibited by a specific inducible NO-synthase (iNOS) inhibitor (aminoguanidine), indicating the implication of this receptor in the astrocyte inflammatory reaction. pimagedine 184-198 interleukin 1 beta Homo sapiens 101-109 11500085-5 2001 Cell surface stimulation of CD23 expressed by astrocytes induced production of nitric oxide (NO) and IL-1beta which was inhibited by a specific inducible NO-synthase (iNOS) inhibitor (aminoguanidine), indicating the implication of this receptor in the astrocyte inflammatory reaction. pimagedine 184-198 nitric oxide synthase 2 Homo sapiens 144-165 11438474-6 2001 Inhibitors of nitric oxide synthase, aminoguanidine, and N(G)-monomethyl-L-arginine, attenuate poly IC + IFN-gamma-induced DNA damage to levels observed in response to poly IC alone, prevent islet cell necrosis, and prevent the inhibitory actions on glucose-stimulated insulin secretion. pimagedine 37-51 interferon gamma Mus musculus 105-114 11465170-3 2001 We examined the effect of a selective iNOS inhibitor, aminoguanidine, on CPB-induced inflammatory response in a rat-CPB model. pimagedine 54-68 nitric oxide synthase 2 Rattus norvegicus 38-42 11426981-7 2001 Moreover, coincubation of OVCAR-3 and HOC-7 with the specific iNOS inhibitor aminoguanidine suppressed apoptosis induced by IFN-gamma, IL-1beta, and TNF-alpha. pimagedine 77-91 interferon gamma Homo sapiens 124-133 11426981-7 2001 Moreover, coincubation of OVCAR-3 and HOC-7 with the specific iNOS inhibitor aminoguanidine suppressed apoptosis induced by IFN-gamma, IL-1beta, and TNF-alpha. pimagedine 77-91 interleukin 1 beta Homo sapiens 135-143 11426981-7 2001 Moreover, coincubation of OVCAR-3 and HOC-7 with the specific iNOS inhibitor aminoguanidine suppressed apoptosis induced by IFN-gamma, IL-1beta, and TNF-alpha. pimagedine 77-91 tumor necrosis factor Homo sapiens 149-158 11428906-1 2001 The current study was designed to evaluate the endotoxin-induced alterations of the mechanisms involved in Ca(2+)handling within the rat thoracic aorta and further to examine whether in vitro inhibition of inducible nitric oxide synthase (iNOS) by aminoguanidine would account for this effect or not. pimagedine 248-262 nitric oxide synthase 2 Rattus norvegicus 206-237 11423074-8 2001 Aminoguanidine, which is a selective inhibitor of iNOS, reduced NOx(-) levels induced by the mixed cytokine treatment. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 50-54 11422452-6 2001 NOS inhibition by aminoguanidine and L-NAME prevented an iNOS-mediated potentiation of 3-hydroxyglutarate neurotoxicity but failed to protect neurons against 3-hydroxyglutarate alone. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 57-61 11423083-2 2001 Because aminoguanidine"s neuroprotective properties have primarily been ascribed to its action as iNOS inhibitor, we also performed a biochemical analysis of nitric oxide metabolites and NOS isoforms in our model of ischaemia. pimagedine 8-22 nitric oxide synthase 2 Rattus norvegicus 98-102 11322934-8 2001 Similarly, intravenous (200-600 micromol/kg) or subplantar (2 micromol/paw) administration of aminoguanidine significantly reduced the MPO values of the SEB-injected paws. pimagedine 94-108 myeloperoxidase Mus musculus 135-138 11412833-0 2001 Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. pimagedine 86-100 solute carrier family 9 member C1 Homo sapiens 45-61 11322934-9 2001 The vasodilator iloprost (0.3 nmol/paw) completely reversed the inhibition by L-NAME or aminoguanidine of the MPO activity in SEB-injected paws. pimagedine 88-102 myeloperoxidase Mus musculus 110-113 11412833-0 2001 Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. pimagedine 86-100 solute carrier family 9 member A1 Homo sapiens 70-74 11182537-6 2001 Moreover, the administration of the preferred inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (400 mg/kg i.p. pimagedine 95-109 nitric oxide synthase 2 Rattus norvegicus 46-77 11412833-3 2001 Furthermore, we found that a novel synthetic aminoguanidine derivative, T-162559 ((5E,7S)-[7-(5-fluoro-2-methylphenyl)-4-methyl-7,8-dihydro-5(6H)-quinolinylideneamino] guanidine dimethanesulfonate), causes a selective inhibition of hNHE1 with more potent activity than cariporide and eniporide (IC50 value of 0.96 nM). pimagedine 45-59 solute carrier family 9 member A1 Homo sapiens 232-237 11358991-3 2001 The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha. pimagedine 27-41 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 113-132 11358991-3 2001 The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha. pimagedine 27-41 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 134-138 11358991-3 2001 The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha. pimagedine 27-41 nuclear factor kappa B subunit 1 Homo sapiens 144-170 11358991-3 2001 The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha. pimagedine 27-41 C-X-C motif chemokine ligand 8 Homo sapiens 244-248 11358991-3 2001 The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha. pimagedine 27-41 C-X-C motif chemokine ligand 8 Homo sapiens 269-273 11358991-3 2001 The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha. pimagedine 27-41 interleukin 1 beta Homo sapiens 318-326 11358991-3 2001 The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha. pimagedine 27-41 tumor necrosis factor Homo sapiens 331-340 11247871-0 2001 Down regulation of interleukin 1beta production in human osteoarthritic synovial tissue and cartilage cultures by aminoguanidine. pimagedine 114-128 interleukin 1 beta Homo sapiens 19-36 11247871-1 2001 OBJECTIVE: To evaluate the effect of aminoguanidine (AG) on de novo interleukin 1beta (IL1beta), nitric oxide (NO), and interleukin 1 receptor antagonist (IL1ra) production by osteoarthritic human synovial tissue and articular cartilage cultures. pimagedine 37-51 interleukin 1 beta Homo sapiens 68-85 11357473-8 2001 Inclusion of aminoguanidine, an inhibitor of cross-linking formation, during collagen glycation restored the MMP-2 activation, suggesting the role of cross-links on the inhibition of MMP-2 activation. pimagedine 13-27 matrix metallopeptidase 2 Homo sapiens 109-114 11357473-8 2001 Inclusion of aminoguanidine, an inhibitor of cross-linking formation, during collagen glycation restored the MMP-2 activation, suggesting the role of cross-links on the inhibition of MMP-2 activation. pimagedine 13-27 matrix metallopeptidase 2 Homo sapiens 183-188 11336443-11 2001 of the inducible NOS (iNOS) inhibitor aminoguanidine (AG) 1 h before and 8 h after trauma by intraperitoneal route. pimagedine 38-52 nitric oxide synthase 2 Homo sapiens 7-20 11336443-11 2001 of the inducible NOS (iNOS) inhibitor aminoguanidine (AG) 1 h before and 8 h after trauma by intraperitoneal route. pimagedine 38-52 nitric oxide synthase 2 Homo sapiens 22-26 11300647-1 2001 The aim of this study was to elucidate cardiac and regional hemodynamics using a nonspecific inhibitor of the constitutive and inducible nitric oxide synthase (NOS), N-methyl-L-arginine (L-NMA), and a specific inhibitor of the inducible NOS, aminoguanidine, in conscious pigs. pimagedine 242-256 nitric oxide synthase 2 Sus scrofa 137-158 11336443-26 2001 The marked attenuation of the posttraumatic necrosis growth by the iNOS inhibitor aminoguanidine strongly indicates an important role of iNOS product in this phenomenon. pimagedine 82-96 nitric oxide synthase 2 Homo sapiens 67-71 11336443-26 2001 The marked attenuation of the posttraumatic necrosis growth by the iNOS inhibitor aminoguanidine strongly indicates an important role of iNOS product in this phenomenon. pimagedine 82-96 nitric oxide synthase 2 Homo sapiens 137-141 11388613-7 2001 Treatment of mice with aminoguanidine (a preferred inducible NO synthase inhibitor) caused 90% mortality in 92" systemic infection, thus supporting a role for NO in the low virulence of this strain. pimagedine 23-37 nitric oxide synthase 2, inducible Mus musculus 51-72 11182537-6 2001 Moreover, the administration of the preferred inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (400 mg/kg i.p. pimagedine 95-109 nitric oxide synthase 2 Rattus norvegicus 79-83 11232769-3 2001 Treatment of rabies virus-infected mice with a selective inhibitor of iNOS, aminoguanidine (AG), significantly delayed their death. pimagedine 76-90 nitric oxide synthase 2, inducible Mus musculus 70-74 11264651-3 2001 To inhibit NO synthesis we used aminoguanidine (AG) as a selective inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 32-46 nitric oxide synthase 2 Rattus norvegicus 80-111 11264651-3 2001 To inhibit NO synthesis we used aminoguanidine (AG) as a selective inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 32-46 nitric oxide synthase 2 Rattus norvegicus 113-117 11330554-0 2001 The effect of advanced glycation end-products and aminoguanidine on TNFalpha production by rat peritoneal macrophages. pimagedine 50-64 tumor necrosis factor Rattus norvegicus 68-76 11301856-5 2001 The treatment of mice with aminoguanidine, a specific iNOS inhibitor, alleviated the acidic polysaccharide-induced suppression of antibody response to sheep red blood cells. pimagedine 27-41 nitric oxide synthase 2, inducible Mus musculus 54-58 11182788-3 2001 Accumulation of TP53 and HSP72 in the wild-type TP53 cells was observed by cocultivation with irradiated mutant TP53 cells, and the accumulation was abolished by the addition of an inhibitor for inducible nitric oxide synthase, aminoguanidine, to the medium. pimagedine 228-242 tumor protein p53 Homo sapiens 16-20 11182788-3 2001 Accumulation of TP53 and HSP72 in the wild-type TP53 cells was observed by cocultivation with irradiated mutant TP53 cells, and the accumulation was abolished by the addition of an inhibitor for inducible nitric oxide synthase, aminoguanidine, to the medium. pimagedine 228-242 heat shock protein family A (Hsp70) member 1A Homo sapiens 25-30 11182788-3 2001 Accumulation of TP53 and HSP72 in the wild-type TP53 cells was observed by cocultivation with irradiated mutant TP53 cells, and the accumulation was abolished by the addition of an inhibitor for inducible nitric oxide synthase, aminoguanidine, to the medium. pimagedine 228-242 tumor protein p53 Homo sapiens 48-52 11182788-3 2001 Accumulation of TP53 and HSP72 in the wild-type TP53 cells was observed by cocultivation with irradiated mutant TP53 cells, and the accumulation was abolished by the addition of an inhibitor for inducible nitric oxide synthase, aminoguanidine, to the medium. pimagedine 228-242 tumor protein p53 Homo sapiens 48-52 11241130-3 2001 The current study examines iNOS expression, NO production, and the effects of selective inhibition of iNOS by aminoguanidine in experimental AAA. pimagedine 110-124 nitric oxide synthase 2 Rattus norvegicus 102-106 11241130-11 2001 Selective inhibition of iNOS with aminoguanidine in elastase-infused aortas significantly reduced aneurysm size (P <.01) compared with elastase infusion alone. pimagedine 34-48 nitric oxide synthase 2 Rattus norvegicus 24-28 11241130-12 2001 Aminoguanidine-treated rats displayed suppression of iNOS expression and plasma nitrite/nitrate production not significantly different from the control group. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 53-57 11330554-1 2001 OBJECTIVE: To evaluate the effect of advanced glycation end-products (AGEs) and the inhibitor of their formation, aminoguanidine, on tumor necrosis factor-alpha (TNFalpha) production (as a functional marker) by rat peritoneal macrophages (PMphi). pimagedine 114-128 tumor necrosis factor Rattus norvegicus 133-160 11330554-1 2001 OBJECTIVE: To evaluate the effect of advanced glycation end-products (AGEs) and the inhibitor of their formation, aminoguanidine, on tumor necrosis factor-alpha (TNFalpha) production (as a functional marker) by rat peritoneal macrophages (PMphi). pimagedine 114-128 tumor necrosis factor Rattus norvegicus 162-170 11179960-4 2001 Of the agmatine taken up, 10% is transformed into polyamines and 50% is transformed into 4-guanidinobutyrate, as demonstrated by HPLC and MS. Inhibition by aminoguanidine and pargyline shows that this is due to diamine oxidase and an aldehyde dehydrogenase. pimagedine 156-170 amine oxidase, copper containing 1 Rattus norvegicus 211-226 11164849-8 2001 A change in inducible NO synthase activity was not observed in normal myocardium 24 h after intestinal ischemia, but 30 min of coronary occlusion significantly increased the inducible NO synthase activity in the preconditioned group, which was abolished by aminoguanidine or S-methylisothiourea sulfate. pimagedine 257-271 nitric oxide synthase 2 Rattus norvegicus 12-33 11164849-8 2001 A change in inducible NO synthase activity was not observed in normal myocardium 24 h after intestinal ischemia, but 30 min of coronary occlusion significantly increased the inducible NO synthase activity in the preconditioned group, which was abolished by aminoguanidine or S-methylisothiourea sulfate. pimagedine 257-271 nitric oxide synthase 2 Rattus norvegicus 174-195 11152022-5 2001 In 8 rats, 2 h after LPS, aminoguanidine, an iNOS selective blocker, was given i.v. pimagedine 26-40 nitric oxide synthase 2 Rattus norvegicus 45-49 11158946-9 2001 The NOS II and diamine oxidase antagonist aminoguanidine, the superoxide anion scavenger superoxide dismutase, and the xanthine oxidase antagonist allopurinol slowed the rates of heme-.NO production, decreased ceruloplasmin and semiquinone levels, and preserved SBF. pimagedine 42-56 amine oxidase, copper containing 1 Rattus norvegicus 15-30 11198360-7 2001 Pretreatment with microinjection of the selective iNOS inhibitor, aminoguanidine (250 pmol), into the bilateral RVLM significantly prolonged phases II and III endotoxemia, blunted the initial and secondary hypotension, and antagonized the upregulation of iNOS mRNA. pimagedine 66-80 nitric oxide synthase 2 Rattus norvegicus 50-54 11571673-10 2001 Aminoguanidine significantly increased TNF-alpha release in PreM. pimagedine 0-14 tumor necrosis factor Homo sapiens 39-48 11268945-8 2001 The increases in the colonic damage scores, wet weight, thiobarbituric acid-reactive substances and myeloperoxidase activity in trinitrobenzene sulfonic acid-colitis were significantly inhibited by aminoguanidine treatment, although they tended to be aggravated by NG-nitro-L-arginine treatment. pimagedine 198-212 myeloperoxidase Rattus norvegicus 100-115 11208990-5 2001 These two groups were then divided into: group 1, animals receiving saline; and group 2, animals receiving aminoguanidine (AG) which is a specific inhibitor of inducible-NO synthase. pimagedine 107-121 nitric oxide synthase 2 Rattus norvegicus 160-181 11205865-4 2001 Aminoguanidine (50 mM) suppressed the expression of ICAM-1 protein. pimagedine 0-14 intercellular adhesion molecule 1 Homo sapiens 52-58 11196180-4 2001 Release of NO by tumor cells and melanocytes was inhibited by a specific iNOS inhibitor, aminoguanidine (AMG). pimagedine 89-103 nitric oxide synthase 2 Homo sapiens 73-77 11196180-4 2001 Release of NO by tumor cells and melanocytes was inhibited by a specific iNOS inhibitor, aminoguanidine (AMG). pimagedine 105-108 nitric oxide synthase 2 Homo sapiens 73-77 11196180-6 2001 By contrast, iNOS inhibition by AMG did not promote apoptosis in normal adult melanocytes. pimagedine 32-35 nitric oxide synthase 2 Homo sapiens 13-17 11145569-12 2001 Furthermore, coincubation of aminoguanidine (NOS inhibitor) with FGF-2 completely abrogated the protective effect of FGF-2 on bcl-2 and bag-1 mRNA levels in PRL-deprived Nb2 cells. pimagedine 29-43 fibroblast growth factor 2 Rattus norvegicus 65-70 11145569-12 2001 Furthermore, coincubation of aminoguanidine (NOS inhibitor) with FGF-2 completely abrogated the protective effect of FGF-2 on bcl-2 and bag-1 mRNA levels in PRL-deprived Nb2 cells. pimagedine 29-43 fibroblast growth factor 2 Rattus norvegicus 117-122 11145569-12 2001 Furthermore, coincubation of aminoguanidine (NOS inhibitor) with FGF-2 completely abrogated the protective effect of FGF-2 on bcl-2 and bag-1 mRNA levels in PRL-deprived Nb2 cells. pimagedine 29-43 BCL2, apoptosis regulator Rattus norvegicus 126-131 11145569-12 2001 Furthermore, coincubation of aminoguanidine (NOS inhibitor) with FGF-2 completely abrogated the protective effect of FGF-2 on bcl-2 and bag-1 mRNA levels in PRL-deprived Nb2 cells. pimagedine 29-43 BAG cochaperone 1 Rattus norvegicus 136-141 11145569-12 2001 Furthermore, coincubation of aminoguanidine (NOS inhibitor) with FGF-2 completely abrogated the protective effect of FGF-2 on bcl-2 and bag-1 mRNA levels in PRL-deprived Nb2 cells. pimagedine 29-43 prolactin Rattus norvegicus 157-160 11835631-1 2001 The effect of aminoguanidine (a selective inhibitor of inducible nitric oxide synthase) on allyl alcohol-induced liver injury was assessed by the measurement of serum ALT and AST activities and histopathological examination. pimagedine 14-28 glutamic pyruvic transaminase, soluble Mus musculus 167-170 11835631-1 2001 The effect of aminoguanidine (a selective inhibitor of inducible nitric oxide synthase) on allyl alcohol-induced liver injury was assessed by the measurement of serum ALT and AST activities and histopathological examination. pimagedine 14-28 transmembrane protease, serine 11d Mus musculus 175-178 11835631-5 2001 In the presence of aminoguanidine the level of ALT and AST enzymes were significantly decreased. pimagedine 19-33 glutamic pyruvic transaminase, soluble Mus musculus 47-50 11835631-5 2001 In the presence of aminoguanidine the level of ALT and AST enzymes were significantly decreased. pimagedine 19-33 transmembrane protease, serine 11d Mus musculus 55-58 11198360-7 2001 Pretreatment with microinjection of the selective iNOS inhibitor, aminoguanidine (250 pmol), into the bilateral RVLM significantly prolonged phases II and III endotoxemia, blunted the initial and secondary hypotension, and antagonized the upregulation of iNOS mRNA. pimagedine 66-80 nitric oxide synthase 2 Rattus norvegicus 255-259 11139367-8 2000 Indeed, the data about the effect of specific inhibitors on the NOS activity revealed that in retinas from GK rats the most effective inhibitor was aminoguanidine, which predominantly inhibits the iNOS isoform whereas in retinas from normal Wistar rats it was N(G) nitro l-arginine that predominantly inhibits the constitutive isoforms of NOS. pimagedine 148-162 nitric oxide synthase 2 Rattus norvegicus 197-201 11082132-2 2000 This study was designed to evaluate the effects of aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), on the reactivity and intracellular calcium ([Ca(2+)](i)) mobilization induced by noradrenaline in the perfused tail artery from aged WAG/Rij rats. pimagedine 51-65 nitric oxide synthase 2 Rattus norvegicus 140-144 11049836-4 2000 Aminoguanidine, a relatively selective inhibitor of iNOS, partially restored contraction to PGF(2alpha) in vessels from iNOS +/+ mice but had no effect in iNOS -/- mice injected with TNF-alpha, suggesting that a mechanism(s) other than iNOS contributes to impaired responses. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 52-56 11049836-4 2000 Aminoguanidine, a relatively selective inhibitor of iNOS, partially restored contraction to PGF(2alpha) in vessels from iNOS +/+ mice but had no effect in iNOS -/- mice injected with TNF-alpha, suggesting that a mechanism(s) other than iNOS contributes to impaired responses. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 120-124 11049836-4 2000 Aminoguanidine, a relatively selective inhibitor of iNOS, partially restored contraction to PGF(2alpha) in vessels from iNOS +/+ mice but had no effect in iNOS -/- mice injected with TNF-alpha, suggesting that a mechanism(s) other than iNOS contributes to impaired responses. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 120-124 11049836-4 2000 Aminoguanidine, a relatively selective inhibitor of iNOS, partially restored contraction to PGF(2alpha) in vessels from iNOS +/+ mice but had no effect in iNOS -/- mice injected with TNF-alpha, suggesting that a mechanism(s) other than iNOS contributes to impaired responses. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 120-124 11049836-6 2000 Responses of carotid arteries from iNOS -/- mice and effects of aminoguanidine suggest that both iNOS-dependent and iNOS-independent mechanisms contribute to impaired contractile responses following TNF-alpha. pimagedine 64-78 tumor necrosis factor Mus musculus 199-208 11105912-8 2000 The increments observed in gammaGTP activity and nitrite production were partially and completely blocked by simultaneous treatment with the NO synthase inhibitor aminoguanidine. pimagedine 163-177 gamma-glutamyltransferase 1 Rattus norvegicus 27-35 11056389-2 2000 We found incidentally that the oral administration of aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS), strongly inhibits the development of lens opacification in SCR. pimagedine 54-68 nitric oxide synthase 2 Rattus norvegicus 91-122 11056389-2 2000 We found incidentally that the oral administration of aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS), strongly inhibits the development of lens opacification in SCR. pimagedine 54-68 nitric oxide synthase 2 Rattus norvegicus 124-128 11035712-2 2000 The proliferative defect is dependent on inducible nitric oxide synthase (iNOS) activity, since inhibition of iNOS with either L-N-monomethyl arginine (L-NMMA) or aminoguanidine reversed defective proliferation. pimagedine 163-177 nitric oxide synthase 2, inducible Mus musculus 41-72 11035712-2 2000 The proliferative defect is dependent on inducible nitric oxide synthase (iNOS) activity, since inhibition of iNOS with either L-N-monomethyl arginine (L-NMMA) or aminoguanidine reversed defective proliferation. pimagedine 163-177 nitric oxide synthase 2, inducible Mus musculus 74-78 11193275-1 2000 OBJECTIVE: To define the acute hemodynamic, metabolic, and morphological changes induced by aminoguanidine, a selective iNOS inhibitor, in septic sheep. pimagedine 92-106 nitric oxide synthase, inducible Ovis aries 120-124 11024544-4 2000 In the periphery of aminoguanidine-treated animals, T lymphocytes showed increased proliferation against myelin basic protein, and the percentage of Vbeta 8.2(+) T lymphocytes undergoing early apoptosis was markedly decreased, although it was unchanged in Vbeta 8.2(+) T cells isolated from the spinal cord. pimagedine 20-34 myelin basic protein Rattus norvegicus 105-125 11040050-8 2000 L-NIL [L-N(6)-(1-Iminoethyl)lysine hydrochloride] and aminoguanidine were moderately iNOS-selective while L-NA (N(G)-nitro-L-arginine) and L-NAME (N(G)-nitro-L-arginine methyl ester hydrochloride) showed selectivity toward the constitutive isoforms. pimagedine 54-68 nitric oxide synthase 2 Homo sapiens 85-89 11015317-5 2000 Likewise, the increase of iNOS expression, nitrotyrosine immunostaining, nitric oxide production and superoxide anion formation in adult SHR were also significantly suppressed by chronic treatment with PDTC and aminoguanidine. pimagedine 211-225 nitric oxide synthase 2 Rattus norvegicus 26-30 11015317-8 2000 However, the effect of aminoguanidine was predominantly mediated by inhibition of iNOS activity, thereby reducing peroxynitrite formation. pimagedine 23-37 nitric oxide synthase 2 Rattus norvegicus 82-86 11009571-6 2000 In vessels from wild-type mice, NE-induced contraction was markedly impaired after LPS, and pretreatment with the iNOS inhibitor aminoguanidine (AG) partly restored the NE contraction. pimagedine 129-143 nitric oxide synthase 2, inducible Mus musculus 114-118 11004044-9 2000 Co-treatment with NS-398 attenuated, but aminoguanidine or dexamethasone abolished the effect of LPS on halothane-induced rCBF increase. pimagedine 41-55 CCAAT/enhancer binding protein zeta Rattus norvegicus 122-126 10973630-1 2000 Aminoguanidine is an inhibitor of inducible nitric oxide synthase (iNOS) and is of potential clinical usefulness. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 34-65 10973630-1 2000 Aminoguanidine is an inhibitor of inducible nitric oxide synthase (iNOS) and is of potential clinical usefulness. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 67-71 10973630-4 2000 The anti-Fas antibody-induced elevation of caspase-3 activity was inhibited by aminoguanidine (30 mg/kg, i.p. pimagedine 79-93 caspase 3 Mus musculus 43-52 10973630-6 2000 Thus, aminoguanidine prevents anti-Fas antibody-induced hepatitis by affecting the apoptotic pathway upstream of caspase-3 activation. pimagedine 6-20 caspase 3 Mus musculus 113-122 10991910-6 2000 The LPS inhibitory effect was reduced by the non-specific NOS inhibitor L-N(G)-nitroarginine methyl ester (L-NAME, 100 microM) and the selective iNOS inhibitor, aminoguanidine (100 microM). pimagedine 161-175 nitric oxide synthase 2 Rattus norvegicus 145-149 11016330-13 2000 Aminoguanidine completely abolished both MLA-induced and ischemia-induced iNOS mRNA and blocked the beneficial effects of MLA. pimagedine 0-14 LOC396821 Sus scrofa 74-78 10898937-10 2000 Aminoguanidine (AG) treatment of diabetic rats returned the testis PHGPx activity (136.5 +/- 24.9) to the control level but did not change the value of GPx activity (69.2 +/- 17.4) compared with diabetic group. pimagedine 0-14 glutathione peroxidase 4 Rattus norvegicus 67-72 11035283-13 2000 Treatment with aminoguanidine, an established inhibitor of nitric oxide synthase, significantly (P <.05) decreased (85%) the IL-1 beta effect. pimagedine 15-29 interleukin 1 beta Rattus norvegicus 128-137 11028758-8 2000 Aminoguanidine, a relatively selective inhibitor of the inducible NO synthase, depending on the dose, showed a biphasic effect on cell migration. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 56-77 10965918-6 2000 Similarly, the specific nNOS inhibitor 7-nitroindazole and the specific inducible NOS (iNOS) inhibitor aminoguanidine (10(-5) M each) provoked a transient depression of the current followed by a sustained potentiation. pimagedine 103-117 nitric oxide synthase 1 Homo sapiens 24-28 10965918-6 2000 Similarly, the specific nNOS inhibitor 7-nitroindazole and the specific inducible NOS (iNOS) inhibitor aminoguanidine (10(-5) M each) provoked a transient depression of the current followed by a sustained potentiation. pimagedine 103-117 nitric oxide synthase 2 Homo sapiens 87-91 11016861-4 2000 NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME. pimagedine 126-140 interleukin 1 beta Rattus norvegicus 30-38 11016861-4 2000 NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME. pimagedine 126-140 transforming growth factor alpha Rattus norvegicus 41-49 10934072-2 2000 We hypothesized that aminoguanidine (AG), a proposed selective inhibitor of iNOS, would alter pulmonary hemodynamics, fluid filtration, and gas exchange after endotoxin in chronically instrumented awake sheep. pimagedine 21-35 nitric oxide synthase, inducible Ovis aries 76-80 10933607-0 2000 Aminoguanidine-induced amelioration of autoimmune encephalomyelitis is mediated by reduced expression of inducible nitric oxide synthase in the spinal cord. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 105-136 10933607-1 2000 To elucidate whether an inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AMG), affects the expression of iNOS in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE), we induced EAE in Lewis rats, and treated EAE rats with AMG. pimagedine 74-88 nitric oxide synthase 2 Rattus norvegicus 24-55 10933607-1 2000 To elucidate whether an inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AMG), affects the expression of iNOS in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE), we induced EAE in Lewis rats, and treated EAE rats with AMG. pimagedine 74-88 nitric oxide synthase 2 Rattus norvegicus 57-61 10933607-1 2000 To elucidate whether an inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AMG), affects the expression of iNOS in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE), we induced EAE in Lewis rats, and treated EAE rats with AMG. pimagedine 74-88 nitric oxide synthase 2 Rattus norvegicus 122-126 10933607-1 2000 To elucidate whether an inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AMG), affects the expression of iNOS in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE), we induced EAE in Lewis rats, and treated EAE rats with AMG. pimagedine 90-93 nitric oxide synthase 2 Rattus norvegicus 24-55 10933607-1 2000 To elucidate whether an inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AMG), affects the expression of iNOS in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE), we induced EAE in Lewis rats, and treated EAE rats with AMG. pimagedine 90-93 nitric oxide synthase 2 Rattus norvegicus 57-61 10933607-1 2000 To elucidate whether an inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AMG), affects the expression of iNOS in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE), we induced EAE in Lewis rats, and treated EAE rats with AMG. pimagedine 90-93 nitric oxide synthase 2 Rattus norvegicus 122-126 10933607-4 2000 Western blot analysis showed that iNOS expression was significantly reduced in the spinal cords of rats with EAE treated with AMG compared with rats treated with the vehicle. pimagedine 126-129 nitric oxide synthase 2 Rattus norvegicus 34-38 10933607-6 2000 The corollary is that the amelioration of EAE paralysis by the treatment with AMG is associated with the suppression of iNOS expression in the target organ i.e. the spinal cord. pimagedine 78-81 nitric oxide synthase 2 Rattus norvegicus 120-124 10869545-10 2000 Aminoguanidine, a selective inhibitor of iNOS, prevented the reduction of BP in males. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 41-45 10807955-3 2000 Aminoguanidine (AG) was used to inhibit inducible nitric oxide synthase (iNOS). pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 40-71 10807955-3 2000 Aminoguanidine (AG) was used to inhibit inducible nitric oxide synthase (iNOS). pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 73-77 10899080-8 2000 Pretreatment with aminoguanidine, a specific iNOS inhibitor, inhibited both iNOS mRNA production and the depressor effect of CT-1. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 45-49 10899080-8 2000 Pretreatment with aminoguanidine, a specific iNOS inhibitor, inhibited both iNOS mRNA production and the depressor effect of CT-1. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 76-80 10899080-8 2000 Pretreatment with aminoguanidine, a specific iNOS inhibitor, inhibited both iNOS mRNA production and the depressor effect of CT-1. pimagedine 18-32 cardiotrophin 1 Rattus norvegicus 125-129 10914498-4 2000 Here, we tested in wild-type mice whether inhibition of NO production by metabolic inhibitors, aminoguanidine (AG) and L-N-(1-iminoethyl)lysine (L-NIL), could mimic the ablation of the IFN-gamma receptor. pimagedine 95-109 interferon gamma Mus musculus 185-194 10904069-6 2000 Separate subgroups were used to test blood pressure response to norepinephrine and the iNOS inhibitor aminoguanidine. pimagedine 102-116 nitric oxide synthase 2 Homo sapiens 87-91 10860773-2 2000 Administration of the non-specific inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (30 mg/kg, subcutaneously) 1 h prior to ischemia blocked the ability of RC-552 (35 microg/kg, 24 h pretreatment) to reduce infarct size. pimagedine 84-98 nitric oxide synthase 2 Canis lupus familiaris 35-66 10860773-2 2000 Administration of the non-specific inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (30 mg/kg, subcutaneously) 1 h prior to ischemia blocked the ability of RC-552 (35 microg/kg, 24 h pretreatment) to reduce infarct size. pimagedine 84-98 nitric oxide synthase 2 Canis lupus familiaris 68-72 10831632-2 2000 We investigated the effects of administering aminoguanidine (AG), a selective inhibitor of inducible NOS (iNOS), on glomerular histology, serum creatinine concentration, albuminuria and haematuria in SHR. pimagedine 45-59 nitric oxide synthase 2 Rattus norvegicus 106-110 11075418-7 2000 PP-36 abolished this effect and led to parallel rising reaction to aminoguanidin in embolized (APsyst: +12.4 +/- 1.6 vs. +6.8 +/- 2.3 mmHg, p < 0.05) as well as in sham operated rats (APsyst: +8.5 +/- 1.1 vs. +5.6 +/- 0.7 mmHg, p < 0.05). pimagedine 67-80 linker for activation of T cells Rattus norvegicus 0-5 10856522-6 2000 Treatment with aminoguanidine, an inhibitor for the formation of advanced glycation end products (AGEs), during glycation normalized the generation of PAI-1 and t-PA induced by glycated Lp(a). pimagedine 15-29 serpin family E member 1 Homo sapiens 151-156 10856522-6 2000 Treatment with aminoguanidine, an inhibitor for the formation of advanced glycation end products (AGEs), during glycation normalized the generation of PAI-1 and t-PA induced by glycated Lp(a). pimagedine 15-29 plasminogen activator, tissue type Homo sapiens 161-165 10856522-6 2000 Treatment with aminoguanidine, an inhibitor for the formation of advanced glycation end products (AGEs), during glycation normalized the generation of PAI-1 and t-PA induced by glycated Lp(a). pimagedine 15-29 lipoprotein(a) Homo sapiens 186-191 10877229-6 2000 Aminoguanidine pretreatment inhibited activity of diamine oxidase and increased the plasma histamine concentration. pimagedine 0-14 amine oxidase, copper containing 1 Rattus norvegicus 50-65 10822065-1 2000 Aminoguanidine is an inhibitor of the inducible form of nitric oxide synthase (iNOS). pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 79-83 10898532-1 2000 The aim of this study was to examine the effect of aminoguanidine (AG), which is thought to be an inducible nitric oxide synthase (iNOS) inhibitor, on lesion volume induced by cold injury in the parietal cortex of the rat. pimagedine 51-65 nitric oxide synthase 2 Rattus norvegicus 98-129 10898532-1 2000 The aim of this study was to examine the effect of aminoguanidine (AG), which is thought to be an inducible nitric oxide synthase (iNOS) inhibitor, on lesion volume induced by cold injury in the parietal cortex of the rat. pimagedine 51-65 nitric oxide synthase 2 Rattus norvegicus 131-135 10775125-6 2000 In septic rats, arteriolar pretreatment with the "selective" iNOS blockers aminoguanidine (AG) or S-methylisothiourea sulfate (SMT) restored the responses to the control level. pimagedine 75-89 nitric oxide synthase 2 Rattus norvegicus 61-65 10788446-0 2000 Aminoguanidine-mediated inactivation and alteration of neuronal nitric-oxide synthase. pimagedine 0-14 nitric oxide synthase 1 Homo sapiens 55-85 10722595-4 2000 Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS). pimagedine 227-241 interleukin 1 beta Homo sapiens 43-47 10845667-14 2000 The increase in hepatic iNOS protein expression at 5 h after partial hepatectomy disappeared with aminoguanidine pretreatment. pimagedine 98-112 nitric oxide synthase 2 Rattus norvegicus 24-28 10764667-6 2000 The apoE-induced nitric oxide production was significantly reduced by coincubation of the cells with aminoguanidine or N(G)-monomethyl-L-arginine (P<0.05) or with antisense iNOS oligodeoxynucleotides (P<0.01). pimagedine 101-115 apolipoprotein E Homo sapiens 4-8 10884975-4 2000 When aminoguanidine, an inhibitor of NO synthesis, was added to the Csk transfectants stimulated with lipopolysaccharide (LPS), not only NO production but also PGE2 production was suppressed. pimagedine 5-19 c-src tyrosine kinase Mus musculus 68-71 10722595-4 2000 Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS). pimagedine 227-241 interleukin 6 Homo sapiens 75-79 10835296-6 2000 Aminoguanidine, a selective inhibitor of inducible nitric oxide synthase (iNOS), abolished the cytokine-induced nitrite generation whereas N-nitro-l-arginine, an inhibitor more selective for other NOS isoforms, was significantly less effective. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 41-72 10882189-2 2000 Results indicate that 1) IL1alpha enhances the synthesis of prostaglandins and augments NO production in pregnant rat uteri and 2) the effect of IL1alpha on prostaglandin synthesis is abolished by NMMA, a NOS inhibitor, by aminoguanidine, an iNOS inhibitor, and by NS-398, a COX-2 inhibitor. pimagedine 223-237 interleukin 1 alpha Rattus norvegicus 25-33 10882189-2 2000 Results indicate that 1) IL1alpha enhances the synthesis of prostaglandins and augments NO production in pregnant rat uteri and 2) the effect of IL1alpha on prostaglandin synthesis is abolished by NMMA, a NOS inhibitor, by aminoguanidine, an iNOS inhibitor, and by NS-398, a COX-2 inhibitor. pimagedine 223-237 interleukin 1 alpha Rattus norvegicus 145-153 10835296-6 2000 Aminoguanidine, a selective inhibitor of inducible nitric oxide synthase (iNOS), abolished the cytokine-induced nitrite generation whereas N-nitro-l-arginine, an inhibitor more selective for other NOS isoforms, was significantly less effective. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 74-78 10688832-1 2000 Recipient IgG immunity against leukoreduced donor platelets is dependent on indirect T-cell allorecognition and is suppressed in vivo by inhibitors (aminoguanidine, AMG) of inducible nitric oxide synthase (iNOS). pimagedine 149-163 nitric oxide synthase 2 Homo sapiens 173-204 10688832-1 2000 Recipient IgG immunity against leukoreduced donor platelets is dependent on indirect T-cell allorecognition and is suppressed in vivo by inhibitors (aminoguanidine, AMG) of inducible nitric oxide synthase (iNOS). pimagedine 149-163 nitric oxide synthase 2 Homo sapiens 206-210 10722866-2 2000 Treatment of confluent L929 cells with cAMP analogues -dibutyryl-cAMP (db-cAMP) or 8-Cl-cAMP caused dose-dependent augmentation of inducible NO synthase (iNOS)-mediated NO production, which has been abrogated by inhibition of protein synthesis with cycloheximide or addition of selective iNOS inhibitor aminoguanidine. pimagedine 303-317 nitric oxide synthase 2, inducible Mus musculus 131-152 10722866-2 2000 Treatment of confluent L929 cells with cAMP analogues -dibutyryl-cAMP (db-cAMP) or 8-Cl-cAMP caused dose-dependent augmentation of inducible NO synthase (iNOS)-mediated NO production, which has been abrogated by inhibition of protein synthesis with cycloheximide or addition of selective iNOS inhibitor aminoguanidine. pimagedine 303-317 nitric oxide synthase 2, inducible Mus musculus 154-158 10820953-7 2000 Aminoguanidine significantly attenuated the reperfusion-related depression of mean arterial pressure (MAP), the decrease in intestinal perfusion index, the decrease in tissue ATP preservation, the increase in tissue malondialdehyde (MDA) level, and the expression of CD11b of circulating granulocytes. pimagedine 0-14 integrin subunit alpha M Rattus norvegicus 267-272 10746547-5 2000 Administration of either of two NOS inhibitors, aminoguanidine (AG) or L-lysine,N6-1-iminoethyl-dihydrochloride, appears to abrogate in part the tumor growth inhibition observed when IL-10 is overexpressed as a transgene in two murine mammary tumor cell lines. pimagedine 48-62 interleukin 10 Mus musculus 183-188 10692520-0 2000 Aminoguanidine ameliorates changes in the IGF system in experimental diabetic nephropathy. pimagedine 0-14 insulin-like growth factor 1 Rattus norvegicus 42-45 10692520-4 2000 METHODS: Quantitative in situ hybridization histochemistry and immunohistochemistry were used to determine the effects of aminoguanidine, an inhibitor of AGE formation, on gene expression of IGF-I and IGFBPs in kidneys of long-term (8 months duration) streptozotocin-diabetic rats. pimagedine 122-136 insulin-like growth factor 1 Rattus norvegicus 191-196 10692520-4 2000 METHODS: Quantitative in situ hybridization histochemistry and immunohistochemistry were used to determine the effects of aminoguanidine, an inhibitor of AGE formation, on gene expression of IGF-I and IGFBPs in kidneys of long-term (8 months duration) streptozotocin-diabetic rats. pimagedine 122-136 insulin-like growth factor binding protein 1 Rattus norvegicus 201-207 10692520-6 2000 Aminoguanidine treatment inhibited the effects of diabetes on renal expression of mRNA for IGF-I, IGFBP-1 and IGFBP-4. pimagedine 0-14 insulin-like growth factor 1 Rattus norvegicus 91-96 10692520-6 2000 Aminoguanidine treatment inhibited the effects of diabetes on renal expression of mRNA for IGF-I, IGFBP-1 and IGFBP-4. pimagedine 0-14 insulin-like growth factor binding protein 1 Rattus norvegicus 98-105 10692520-6 2000 Aminoguanidine treatment inhibited the effects of diabetes on renal expression of mRNA for IGF-I, IGFBP-1 and IGFBP-4. pimagedine 0-14 insulin-like growth factor binding protein 4 Rattus norvegicus 110-117 10692520-9 2000 CONCLUSIONS: These results suggest that amelioration of changes in the renal IGF system by aminoguanidine may contribute to the renoprotective effects of the latter, which have been previously shown to inhibit structural and functional aspects of diabetic nephropathy in the rat. pimagedine 91-105 insulin-like growth factor 1 Rattus norvegicus 77-80 10735541-6 2000 Aminoguanidine was used to inhibit inducible nitric oxide synthase (iNOS) activity. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 68-72 10650128-3 2000 Purpose of this paper was both the analysis of the individual clinical evolution of EAE induced in Lewis female rats by active immunisation and the evaluation of the effect of treatment with aminoguanidine, a selective inhibitor for the inducible isoform of nitric oxide synthase (iNOS). pimagedine 191-205 nitric oxide synthase 2 Rattus norvegicus 281-285 10615072-7 2000 TNF for 0.5 h induced an increase in PKG activity that was prevented by aminoguanidine, ODQ, KT5823, and 8-bromo-cGMP-thioate; however, SOD had no effect. pimagedine 72-86 tumor necrosis factor Homo sapiens 0-3 10646531-7 2000 Administration of the selective iNOS inhibitor aminoguanidine (400 mg/kg i.p. pimagedine 47-61 nitric oxide synthase 2 Rattus norvegicus 32-36 10615072-4 2000 The effects of TNF were prevented by the superoxide radical scavenger superoxide dismutase (SOD) (100 U/ml), the (*)NO synthase inhibitor aminoguanidine (100 microM), the guanylate cyclase inhibitor ODQ (100 microM), and the PKG inhibitors KT5823 (1 microM) and 8-bromo-cyclic guanosine monophosphate (cGMP)-thioate (100 microM). pimagedine 138-152 tumor necrosis factor Homo sapiens 15-18 10670845-14 2000 Aminoguanidine, a relatively selective iNOS inhibitor, completely prevented NE depletion in all tissues and partially prevented adrenal EPI depletion induced by LPS. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 39-43 10619828-5 2000 In addition, tumor necrosis factor-alpha (TNF-alpha) plus IL-1beta plus interferon-gamma (IFN-gamma) increased IL-8 in culture supernatant of epithelial cells; the combination of NO synthase (NOS) inhibitors, aminoguanidine (AG) plus N(G)-nitro-L-arginine methyl ester (L-NAME) attenuated the cytokine-induced IL-8 production in epithelial cells. pimagedine 209-223 tumor necrosis factor Cavia porcellus 13-40 10619828-5 2000 In addition, tumor necrosis factor-alpha (TNF-alpha) plus IL-1beta plus interferon-gamma (IFN-gamma) increased IL-8 in culture supernatant of epithelial cells; the combination of NO synthase (NOS) inhibitors, aminoguanidine (AG) plus N(G)-nitro-L-arginine methyl ester (L-NAME) attenuated the cytokine-induced IL-8 production in epithelial cells. pimagedine 209-223 tumor necrosis factor Cavia porcellus 42-51 10619828-5 2000 In addition, tumor necrosis factor-alpha (TNF-alpha) plus IL-1beta plus interferon-gamma (IFN-gamma) increased IL-8 in culture supernatant of epithelial cells; the combination of NO synthase (NOS) inhibitors, aminoguanidine (AG) plus N(G)-nitro-L-arginine methyl ester (L-NAME) attenuated the cytokine-induced IL-8 production in epithelial cells. pimagedine 209-223 interleukin-1 beta Cavia porcellus 58-66 10619828-5 2000 In addition, tumor necrosis factor-alpha (TNF-alpha) plus IL-1beta plus interferon-gamma (IFN-gamma) increased IL-8 in culture supernatant of epithelial cells; the combination of NO synthase (NOS) inhibitors, aminoguanidine (AG) plus N(G)-nitro-L-arginine methyl ester (L-NAME) attenuated the cytokine-induced IL-8 production in epithelial cells. pimagedine 209-223 interferon gamma Cavia porcellus 72-88 10619828-5 2000 In addition, tumor necrosis factor-alpha (TNF-alpha) plus IL-1beta plus interferon-gamma (IFN-gamma) increased IL-8 in culture supernatant of epithelial cells; the combination of NO synthase (NOS) inhibitors, aminoguanidine (AG) plus N(G)-nitro-L-arginine methyl ester (L-NAME) attenuated the cytokine-induced IL-8 production in epithelial cells. pimagedine 209-223 interferon gamma Cavia porcellus 90-99 11268352-6 2000 The administration of a specific iNOS inhibitor, aminoguanidine (AG), with LPS not only decreased NOS activity but significantly decreased PGE content, indicating that NO triggered the activation of COX-2. pimagedine 49-63 nitric oxide synthase 2 Homo sapiens 33-37 11268352-6 2000 The administration of a specific iNOS inhibitor, aminoguanidine (AG), with LPS not only decreased NOS activity but significantly decreased PGE content, indicating that NO triggered the activation of COX-2. pimagedine 49-63 prostaglandin-endoperoxide synthase 2 Homo sapiens 199-204 10615072-5 2000 Spermine-NO (1 microM) and L-arginine (400 microM) prevented the aminoguanidine-induced ablation of AP-1 activation in response to TNF. pimagedine 65-79 tumor necrosis factor Homo sapiens 131-134 10615072-7 2000 TNF for 0.5 h induced an increase in PKG activity that was prevented by aminoguanidine, ODQ, KT5823, and 8-bromo-cGMP-thioate; however, SOD had no effect. pimagedine 72-86 protein kinase cGMP-dependent 1 Homo sapiens 37-40 11469395-0 2000 Aminoguanidine exerts a beta-cell function-preserving effect in high glucose-cultured beta-cells (INS-1). pimagedine 0-14 insulin 1 Rattus norvegicus 98-103 10666002-1 2000 The present study was undertaken to evaluate the effect of aminoguanidine (AG) on carbon tetrachloride (CCl4)-induced hepatotoxicity. pimagedine 59-73 chemokine (C-C motif) ligand 4 Mus musculus 104-108 10639005-5 1999 Aminoguanidine, an inhibitor of NOS-2, blocks endotoxin- induced increase of resistance in mesenteric bed and endotoxin-induced translocation of bacteria through the gut wall. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 32-37 10871432-4 2000 Furthermore, we assessed the effect of aminoguanidine, an inducible NOS (iNOS) inhibitor, on the cGMP content increase induced by Lx in LPS-treated human pulmonary artery smooth muscle cells (HPASMC). pimagedine 39-53 nitric oxide synthase 2 Homo sapiens 58-71 10871432-4 2000 Furthermore, we assessed the effect of aminoguanidine, an inducible NOS (iNOS) inhibitor, on the cGMP content increase induced by Lx in LPS-treated human pulmonary artery smooth muscle cells (HPASMC). pimagedine 39-53 nitric oxide synthase 2 Homo sapiens 73-77 10625572-8 2000 Administration of the inhibitor of advanced glycation end-product formation, aminoguanidine, to diabetic rats attenuated both the hypertrophic response in mesenteric vessels and the overexpression of SPARC mRNA and protein without affecting glycemic control or food intake. pimagedine 77-91 secreted protein acidic and cysteine rich Rattus norvegicus 200-205 10651154-7 2000 Aminoguanidine inhibited nitrite levels and iNOS activity in addition to exerting inhibitory effects on the COX pathway. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 44-48 10625086-3 2000 We demonstrate here that aminoguanidine, a relatively selective inhibitor of inducible NO synthase, ameliorated neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. pimagedine 25-39 nitric oxide synthase 2 Rattus norvegicus 77-98 10625086-3 2000 We demonstrate here that aminoguanidine, a relatively selective inhibitor of inducible NO synthase, ameliorated neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. pimagedine 230-244 nitric oxide synthase 2 Rattus norvegicus 77-98 11023038-6 2000 The [3H]glucosamine uptake was completely inhibited by the non-selective NO synthase (NOS) inhibitors, N(G)-nitro-L-arginine and N(G)-monomethyl-L-arginine, and it was only partially inhibited by a more selective inhibitor for inducible NOS isoform (iNOS), aminoguanidine. pimagedine 257-271 nitric oxide synthase, inducible Cavia porcellus 73-84 10653521-2 2000 Nitrite production was inhibited by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine, as well as the transcription inhibitor actinomycin D. pimagedine 89-103 nitric oxide synthase 2 Rattus norvegicus 40-71 10653521-2 2000 Nitrite production was inhibited by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine, as well as the transcription inhibitor actinomycin D. pimagedine 89-103 nitric oxide synthase 2 Rattus norvegicus 73-77 10586945-8 1999 Induction of iNOS by retinal proteins was inhibited by the iNOS-specific inhibitor aminoguanidine and the tyrosine kinase inhibitor genistein. pimagedine 83-97 nitric oxide synthase 2 Rattus norvegicus 13-17 10586945-8 1999 Induction of iNOS by retinal proteins was inhibited by the iNOS-specific inhibitor aminoguanidine and the tyrosine kinase inhibitor genistein. pimagedine 83-97 nitric oxide synthase 2 Rattus norvegicus 59-63 10608542-13 1999 Aminoguanidine administration (1 mg/kg) 0.5 hour before ischemia and 1 hour after reperfusion significantly increased MAP, increased intestine and liver perfusion, decreased adhesion, and decreased circulating granulocytes and CD 11b expression. pimagedine 0-14 integrin subunit alpha M Rattus norvegicus 227-233 10563466-5 1999 Secondly, AMG inhibits NO synthase particularly the inducible NO synthase isoform making AMG an important pharmacological tool. pimagedine 10-13 nitric oxide synthase 2 Homo sapiens 52-73 10761399-5 1999 Induction of inducible nitric oxide synthase (iNOS) by retinal proteins was inhibited by the iNOS-specific inhibitor, aminoguanidine, and the tyrosine inhibitor, genistein. pimagedine 118-132 nitric oxide synthase 2 Rattus norvegicus 13-44 10761399-5 1999 Induction of inducible nitric oxide synthase (iNOS) by retinal proteins was inhibited by the iNOS-specific inhibitor, aminoguanidine, and the tyrosine inhibitor, genistein. pimagedine 118-132 nitric oxide synthase 2 Rattus norvegicus 46-50 10528202-4 1999 Mice treated with aminoguanidine, a selective inhibitor of iNOS, exhibited cachexia and exacerbated liver pathology, suggesting that NO limits hepatocyte damage when the liver is first exposed to eggs. pimagedine 18-32 nitric oxide synthase 2, inducible Mus musculus 59-63 10528202-8 1999 Nevertheless, the underlying importance of NO is illustrated by the finding that aminoguanidine treatment leads to more severe liver disease and reduced time to death in infected IL-4-/- mice. pimagedine 81-95 interleukin 4 Mus musculus 179-183 10529383-4 1999 Antioxidants, NAC, PDTC, and aminoguanidine, attenuated the gene expression and activity of PPAR gamma induced by AGEs. pimagedine 29-43 peroxisome proliferator activated receptor gamma Homo sapiens 92-102 10588814-5 1999 To clarify which subtype of NO synthase (NOS) (constitutive (cNOS) or inducible (iNOS)) participates in down-regulation of testicular steroidogenesis, aminoguanidine hydrochloride (AG), a selective iNOS inhibitor, was employed. pimagedine 151-179 nitric oxide synthase 2 Homo sapiens 28-39 12548860-4 1999 Activity of iNOS was concentration-dependently inhibited by NOS inhibitors such as L-NNA and aminoguanidine. pimagedine 93-107 nitric oxide synthase 2, inducible Mus musculus 12-16 10482632-10 1999 Inhibition of iNOS by aminoguanidine resulted in prolonged survival and decreased mortality in MVE-infected mice. pimagedine 22-36 nitric oxide synthase 2, inducible Mus musculus 14-18 10512928-6 1999 Aminoguanidine, an inhibitor of inducible nitric oxide synthase (iNOS), had no significant effect on contraction of the carotid artery from LPS-treated control mice but restored contraction of the carotid artery in response to U46619 in IL-10-deficient mice to levels seen in wild-type mice. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 32-63 10512928-6 1999 Aminoguanidine, an inhibitor of inducible nitric oxide synthase (iNOS), had no significant effect on contraction of the carotid artery from LPS-treated control mice but restored contraction of the carotid artery in response to U46619 in IL-10-deficient mice to levels seen in wild-type mice. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 65-69 10512928-6 1999 Aminoguanidine, an inhibitor of inducible nitric oxide synthase (iNOS), had no significant effect on contraction of the carotid artery from LPS-treated control mice but restored contraction of the carotid artery in response to U46619 in IL-10-deficient mice to levels seen in wild-type mice. pimagedine 0-14 interleukin 10 Mus musculus 237-242 10512928-9 1999 Impaired contractile function was eliminated by aminoguanidine, suggesting that expression of iNOS is enhanced in arteries from IL-10-deficient mice. pimagedine 48-62 nitric oxide synthase 2, inducible Mus musculus 94-98 10512928-9 1999 Impaired contractile function was eliminated by aminoguanidine, suggesting that expression of iNOS is enhanced in arteries from IL-10-deficient mice. pimagedine 48-62 interleukin 10 Mus musculus 128-133 10462538-8 1999 When this overproduction of NO in the LPS-treated rats was inhibited in vivo by a single or repeat doses of either a general NOS inhibitor N(G)-nitro-L-arginine or a specific iNOS inhibitor aminoguanidine, the FMO1 mRNA levels were not severely depressed (70-85% of the control level). pimagedine 190-204 nitric oxide synthase 2 Rattus norvegicus 175-179 10574470-5 1999 Likewise, aminoguanidine (a relatively selective iNOS inhibitor) reduced the severity of damage, irrespective whether given twice or as a single injection 6 hr after indomethacin. pimagedine 10-24 nitric oxide synthase 2 Rattus norvegicus 49-53 10486143-5 1999 Aminoguanidine-induced nNOS inactivation produced covalent modification of the nNOS protein chain with a stoichiometry of 0.8 mol of aminoguanidine per mole of the nNOS monomer. pimagedine 0-14 nitric oxide synthase 1 Homo sapiens 23-27 10486143-5 1999 Aminoguanidine-induced nNOS inactivation produced covalent modification of the nNOS protein chain with a stoichiometry of 0.8 mol of aminoguanidine per mole of the nNOS monomer. pimagedine 0-14 nitric oxide synthase 1 Homo sapiens 79-83 10486143-5 1999 Aminoguanidine-induced nNOS inactivation produced covalent modification of the nNOS protein chain with a stoichiometry of 0.8 mol of aminoguanidine per mole of the nNOS monomer. pimagedine 0-14 nitric oxide synthase 1 Homo sapiens 79-83 10486143-5 1999 Aminoguanidine-induced nNOS inactivation produced covalent modification of the nNOS protein chain with a stoichiometry of 0.8 mol of aminoguanidine per mole of the nNOS monomer. pimagedine 133-147 nitric oxide synthase 1 Homo sapiens 23-27 10486143-5 1999 Aminoguanidine-induced nNOS inactivation produced covalent modification of the nNOS protein chain with a stoichiometry of 0.8 mol of aminoguanidine per mole of the nNOS monomer. pimagedine 133-147 nitric oxide synthase 1 Homo sapiens 79-83 10486143-5 1999 Aminoguanidine-induced nNOS inactivation produced covalent modification of the nNOS protein chain with a stoichiometry of 0.8 mol of aminoguanidine per mole of the nNOS monomer. pimagedine 133-147 nitric oxide synthase 1 Homo sapiens 79-83 10486143-6 1999 Specific covalent modification by aminoguanidine was exclusively associated with the oxygenase domain of the nNOS. pimagedine 34-48 nitric oxide synthase 1 Homo sapiens 109-113 10486143-7 1999 The mechanisms by which N(6)-(1-iminoethyl)-l-lysine and aminoguanidine inactivate the nNOS and iNOS do not differ between the isoforms. pimagedine 57-71 nitric oxide synthase 1 Homo sapiens 87-91 10486143-7 1999 The mechanisms by which N(6)-(1-iminoethyl)-l-lysine and aminoguanidine inactivate the nNOS and iNOS do not differ between the isoforms. pimagedine 57-71 nitric oxide synthase 2 Homo sapiens 96-100 10486143-9 1999 1 for N(6)-(1-iminoethyl)-l-lysine and 12 +/- 1.5 for aminoguanidine in case of the iNOS isoform while the same inactivators produced the partition ratios of 17 +/- 2 and 206 +/- 4, respectively, for the nNOS isoform. pimagedine 54-68 nitric oxide synthase 2 Homo sapiens 84-88 10501626-2 1999 This haloperidol-induced macrophage activation seems to be involved in its antitumoral effect since cotreatment with the iNOS inhibitor aminoguanidine was able to reverse the inhibitory effect of haloperidol on the development of the Ehrlich solid carcinoma. pimagedine 136-150 nitric oxide synthase 2, inducible Mus musculus 121-125 10438910-5 1999 There is relative enhancement of IFN-gamma production by immune T cells from mice immunized under aminoguanidine cover. pimagedine 98-112 interferon gamma Mus musculus 33-42 10477114-4 1999 Aminoguanidine significantly reduced the ischemic change and angiogenesis in these regions, and also reduced iNOS-immunoreactive cells compared to the hypoxia group. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 109-113 10438910-4 1999 Macrophage IL-12 induction is enhanced by iNOS inhibitors such as aminoguanidine and thiocitrulline and is inhibited by NO generation via sodium nitroprusside. pimagedine 66-80 nitric oxide synthase 2, inducible Mus musculus 42-46 10417150-7 1999 Moreover, in vivo, the treatment of infected WT mice with the inducible nitric oxide synthase inhibitor aminoguanidine also led to decreased NO and apoptosis levels but not Fas expression, suggesting that IFN-gamma modulates apoptosis induction by two independent and distinct mechanisms: induction of NO production and of Fas and Fas-L expression. pimagedine 104-118 interferon gamma Mus musculus 205-214 10449799-4 1999 Using this rat model of unilateral glaucoma, we treated a group of animals for 6 months with aminoguanidine, a relatively specific inhibitor of NOS-2, and compared them with an untreated group. pimagedine 93-107 nitric oxide synthase 2 Rattus norvegicus 144-149 10417150-7 1999 Moreover, in vivo, the treatment of infected WT mice with the inducible nitric oxide synthase inhibitor aminoguanidine also led to decreased NO and apoptosis levels but not Fas expression, suggesting that IFN-gamma modulates apoptosis induction by two independent and distinct mechanisms: induction of NO production and of Fas and Fas-L expression. pimagedine 104-118 Fas ligand (TNF superfamily, member 6) Mus musculus 331-336 10417671-4 1999 Treatment of infected mice with anti-TNF-alpha monoclonal antibody (mAb) or the iNOS inhibitor, aminoguanidine, prevented necrosis and prolonged time to death. pimagedine 96-110 nitric oxide synthase 2, inducible Mus musculus 80-84 10397271-5 1999 The accumulation of heat shock protein 72 (hsp72) and p53 was observed in nontreated mtp53 cells cocultivated with heated mp53 cells, and the accumulation of these proteins was suppressed by the addition of a specific inducible nitric oxide synthase inhibitor, aminoguanidine, to the medium. pimagedine 261-275 heat shock protein family A (Hsp70) member 1A Homo sapiens 20-41 10397271-5 1999 The accumulation of heat shock protein 72 (hsp72) and p53 was observed in nontreated mtp53 cells cocultivated with heated mp53 cells, and the accumulation of these proteins was suppressed by the addition of a specific inducible nitric oxide synthase inhibitor, aminoguanidine, to the medium. pimagedine 261-275 heat shock protein family A (Hsp70) member 1A Homo sapiens 43-48 10440132-0 1999 Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-alpha and inducible nitric oxide synthase in diabetic rat glomeruli. pimagedine 115-129 nitric oxide synthase 2 Rattus norvegicus 197-228 10440132-8 1999 Treatment with aminoguanidine reduced the expression of TNF-alpha, inducible nitric oxide synthase and intraglomerular NO2-/NO3- production. pimagedine 15-29 tumor necrosis factor Rattus norvegicus 56-65 10440132-8 1999 Treatment with aminoguanidine reduced the expression of TNF-alpha, inducible nitric oxide synthase and intraglomerular NO2-/NO3- production. pimagedine 15-29 nitric oxide synthase 2 Rattus norvegicus 67-98 10357916-9 1999 In additional experiments and using a similar protocol, intraperitoneal administration of aminoguanidine (45 mg/kg), an iNOS inhibitor, reversed lipopolysaccharide-induced gastric injury and restored gastric mucosal blood flow to baseline, whereas the nonselective NOS inhibitor, NG-nitro-l-arginine methyl ester (5 mg/kg) did not. pimagedine 90-104 nitric oxide synthase 2 Rattus norvegicus 120-124 10383821-4 1999 Aminoguanidine (AG), a specific inhibitor of iNOS, was injected intraperitoneally (ip) on 1, 3, 5, 8, 10, and 12 days post-TMEV inoculation as induction phase or 15, 17, 19, 22, 24, and 26 days as effector phase. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 45-49 10373483-0 1999 Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. pimagedine 162-176 tumor necrosis factor Homo sapiens 0-27 10443512-0 1999 Aminoguanidine inhibits inducible NOS and reverses cardiac dysfunction late after ischemia and reperfusion--implications for iNOS-mediated myocardial stunning. pimagedine 0-14 nitric oxide synthase, inducible Oryctolagus cuniculus 125-129 10442853-4 1999 Simultaneous administration of LPS and aminoguanidine (AG; an inhibitor to NO synthase) rescued the LPS-induced fetal abortion, reduced maternal spleen weight to physiological levels, and decreased serum NO concentration to control levels. pimagedine 39-53 toll-like receptor 4 Mus musculus 100-103 10443512-6 1999 However, AMG significantly inhibited iNOS activity, significantly improved left-ventricular maximum + dP/dt and decreased LVEDP, whereas administration of L-arginine reduced + dP/dt and slightly increased LVEDP, compared to AMG-treated animals. pimagedine 9-12 nitric oxide synthase, inducible Oryctolagus cuniculus 37-41 10229855-9 1999 NO- and caspase 1 seem to be independently activated in that aminoguanidine did not affect caspase 1 activation and the inhibitor of caspase 1, Tyr-Val-Ala-Asp-acylooxymethylketone, did not block NO- production; however, both treatments inhibited apoptosis. pimagedine 61-75 caspase 1 Mus musculus 8-17 10334815-11 1999 The effects of LPS on the induction of delayed hypotension and NO formation in the NTS were abolished by pretreatment with the iNOS inhibitor aminoguanidine. pimagedine 142-156 nitric oxide synthase 2 Rattus norvegicus 127-131 10342787-5 1999 Inhibition of iNOS by aminoguanidine (0.1% in drinking water) for 9 months, beginning at 13 months of age, reduced blood pressure, improved glomerular filtration rate by 70%, and renal plasma flow by 40%, whereas glomerular sclerosis was considerably reduced. pimagedine 22-36 nitric oxide synthase 2 Rattus norvegicus 14-18 10342787-8 1999 These findings suggest that aminoguanidine attenuates aging renal dysfunction by inhibiting a pathophysiologic function of iNOS that is independent of free radical-mediated lipid peroxidation or significant effects on AGE deposition. pimagedine 28-42 nitric oxide synthase 2 Rattus norvegicus 123-127 10235127-6 1999 This deteriorative action of postadministration of L-arginine (300 mg/kg intraperitoneally) was prevented by pretreatment with aminoguanidine (100 mg/kg subcutaneously), a selective iNOS inhibitor, with inhibition of increases in gastric mucosal iNOS activity and nitrite/nitrate concentration. pimagedine 127-141 nitric oxide synthase 2 Rattus norvegicus 182-186 10233142-3 1999 Aminoguanidine has been shown to be a selective iNOS inhibitor and to correct the endotoxin-mediated vascular hypocontractility in vitro. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 48-52 10233142-8 1999 Aminoguanidine (17.5 mg/kg) did not alter the mean arterial pressure; however, it did inhibit induced iNOS (but not constitutive NOS) activity in the lung and thoracic aorta from septic animals. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 102-106 10233142-10 1999 Thus selective inhibition of iNOS in vivo with aminoguanidine is possible, but our data suggest that other mechanisms, in addition to iNOS induction, are responsible for the loss of vascular tone characteristic of sepsis. pimagedine 47-61 nitric oxide synthase 2 Rattus norvegicus 29-33 10336849-6 1999 Twenty-four hours later, they were anesthetized and subjected to 20 min ischemia with 60 min reperfusion, in the absence or the presence of the iNOS inhibitor aminoguanidine (300 mg/kg i.p.). pimagedine 159-173 nitric oxide synthase 2 Rattus norvegicus 144-148 10235127-6 1999 This deteriorative action of postadministration of L-arginine (300 mg/kg intraperitoneally) was prevented by pretreatment with aminoguanidine (100 mg/kg subcutaneously), a selective iNOS inhibitor, with inhibition of increases in gastric mucosal iNOS activity and nitrite/nitrate concentration. pimagedine 127-141 nitric oxide synthase 2 Rattus norvegicus 246-250 10435048-6 1999 The effects were maximal at 6 h and both NG-monomethyl-L-arginine and aminoguanidine caused significant reversal of the IL-1 beta effects. pimagedine 70-84 interleukin 1 beta Homo sapiens 120-129 10212230-4 1999 iNOS expression and nitrite production by rat islets in response to poly(IC) + IFN-gamma correlate with an inhibition of insulin secretion and islet degeneration, effects that are prevented by the iNOS inhibitor aminoguanidine (AG). pimagedine 212-226 nitric oxide synthase 2 Rattus norvegicus 0-4 10212230-4 1999 iNOS expression and nitrite production by rat islets in response to poly(IC) + IFN-gamma correlate with an inhibition of insulin secretion and islet degeneration, effects that are prevented by the iNOS inhibitor aminoguanidine (AG). pimagedine 212-226 interferon gamma Rattus norvegicus 79-88 10212230-4 1999 iNOS expression and nitrite production by rat islets in response to poly(IC) + IFN-gamma correlate with an inhibition of insulin secretion and islet degeneration, effects that are prevented by the iNOS inhibitor aminoguanidine (AG). pimagedine 212-226 nitric oxide synthase 2 Rattus norvegicus 197-201 10344467-7 1999 RESULTS: A constitutive release of putrescine was disclosed within 5 h if serum diamine oxidase was inhibited by 10 microM aminoguanidine. pimagedine 123-137 amine oxidase, copper containing 1 Rattus norvegicus 80-95 10372598-9 1999 The study was divided into three treatments: 0.9% NaCl (NaCI), CIM (3 mg/kg), and aminoguanidine (AG; 25 mg/kg), an inhibitor of iNOS. pimagedine 82-96 nitric oxide synthase 2 Equus caballus 129-133 9971752-7 1999 Additionally, despite having increased levels of inducible nitric oxide synthetase (iNOS) expression, treatment of Tg mice with the iNOS inhibitor aminoguanidine did not alter the level of protection afforded by IFN-gamma expression. pimagedine 147-161 nitric oxide synthase 2, inducible Mus musculus 132-136 10210152-5 1999 These lesions induced by indomethacin were prevented by aminoguanidine (a selective inhibitor of iNOS), dexamethasone (an inhibitor of iNOS mRNA transcription), allopurinol (a xanthine oxidase inhibitor), hydroxyurea (a neutrophil reducing agent) and FR167653 (an inhibitor of interleukin-1/tumor necrosis factor-alpha production) as well as 16,16-dimethyl prostaglandin E2n. pimagedine 56-70 nitric oxide synthase 2 Rattus norvegicus 97-101 10075061-5 1999 INTERVENTIONS: Rats were injected with PAF, either alone or after the following pretreatments: a) selective iNOS inhibitors aminoguanidine or S-methylisothiourea; b) 3-morpholinosydnonimine, a NO donor; c) S-methylisothiourea + 3-morpholinosydnonimine; and d) antineutrophil antibody (to deplete neutrophils). pimagedine 124-138 PCNA clamp associated factor Rattus norvegicus 39-42 10090345-9 1999 Inhibition of iNOS activity with aminoguanidine reduced infarct size by 20% but had no effect on infiltration by neutrophils, whereas the more selective inhibitor S-methylisothiourea sulfate reduced infarct size by 41%. pimagedine 33-47 nitric oxide synthase 2 Rattus norvegicus 14-18 9950888-5 1999 NO) synthase (iNOS)-selective inhibitor aminoguanidine (AG) initiated 24 h after NNMU administration improve the survival of NNMU-treated animals. pimagedine 40-54 nitric oxide synthase 2 Rattus norvegicus 14-18 10682399-7 1999 The administration of the preferred iNOS inhibitor aminoguanidine (400 mg/kg i.p. pimagedine 51-65 nitric oxide synthase 2 Rattus norvegicus 36-40 10188982-8 1999 Furthermore, administration of aminoguanidine (300 mg kg(-1), s.c.), a relatively selective inhibitor of iNOS activity, 60 min before sustained ischaemia also abolished the delayed protection afforded by ischaemic preconditioning (infarct size 40.0+/-6.0%). pimagedine 31-45 nitric oxide synthase, inducible Oryctolagus cuniculus 105-109 10075015-2 1999 IFN-gamma-induced NO production in L929 cells was mediated through an iNOS-dependent L-arginine-NO pathway, since it was abrogated by a selective inhibitor of iNOS, aminoguanidine. pimagedine 165-179 interferon gamma Mus musculus 0-9 10075015-2 1999 IFN-gamma-induced NO production in L929 cells was mediated through an iNOS-dependent L-arginine-NO pathway, since it was abrogated by a selective inhibitor of iNOS, aminoguanidine. pimagedine 165-179 nitric oxide synthase 2, inducible Mus musculus 70-74 10075015-2 1999 IFN-gamma-induced NO production in L929 cells was mediated through an iNOS-dependent L-arginine-NO pathway, since it was abrogated by a selective inhibitor of iNOS, aminoguanidine. pimagedine 165-179 nitric oxide synthase 2, inducible Mus musculus 159-163 10100007-6 1999 The rats were treated with the non-specific nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME), and the iNOS inhibitor aminoguanidine in the presence and absence of low-dose antiprogestin, onapristone, and evaluated on days 9 p.c. pimagedine 148-162 nitric oxide synthase 2 Rattus norvegicus 133-137 10025567-5 1999 This diminished particulate PKC alpha isoform was prevented by the treatment of aminoguanidine. pimagedine 80-94 protein kinase C, alpha Rattus norvegicus 28-37 9989468-5 1999 Both 7-nitroindazole and aminoguanidine significantly antagonized the increases of cNOS and iNOS activities measured by conversion of 3H-L-arginine to 3H-L-citrulline in the ventral spinal cord, and blocked the Dyn-induced increases of ncNOS-immunoreactivity in the ventral horn cells 4 h after i.t. pimagedine 25-39 nitric oxide synthase 3 Rattus norvegicus 83-87 9989468-5 1999 Both 7-nitroindazole and aminoguanidine significantly antagonized the increases of cNOS and iNOS activities measured by conversion of 3H-L-arginine to 3H-L-citrulline in the ventral spinal cord, and blocked the Dyn-induced increases of ncNOS-immunoreactivity in the ventral horn cells 4 h after i.t. pimagedine 25-39 nitric oxide synthase 2 Rattus norvegicus 92-96 9848857-0 1998 Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats. pimagedine 97-111 nitric oxide synthase 2 Rattus norvegicus 0-31 10369188-2 1999 The accumulation of hsp72 and p53 was observed in A-172 cells cocultivated with heat-shocked T98G cells, which was suppressed by the addition of aminoguanidine to the medium. pimagedine 145-159 heat shock protein family A (Hsp70) member 1A Homo sapiens 20-25 10369188-2 1999 The accumulation of hsp72 and p53 was observed in A-172 cells cocultivated with heat-shocked T98G cells, which was suppressed by the addition of aminoguanidine to the medium. pimagedine 145-159 tumor protein p53 Homo sapiens 30-33 9865714-2 1998 Both the NO signal and radiosensitization were counteracted by the NO scavenger oxyhemoglobin, by the specific iNOS inhibitor aminoguanidine, and by the L-arginine analogue N(G)-monomethyl-L-arginine. pimagedine 126-140 nitric oxide synthase 2, inducible Mus musculus 111-115 9846976-4 1998 In addition, equivalent numbers of dispersed lung cells from L-NAME- and aminoguanidine-treated mice produced significantly higher levels of IL-4, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1alpha and significantly lower levels of eotaxin compared with D-NAME-treated mice. pimagedine 73-87 interleukin 4 Mus musculus 141-145 9846976-4 1998 In addition, equivalent numbers of dispersed lung cells from L-NAME- and aminoguanidine-treated mice produced significantly higher levels of IL-4, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1alpha and significantly lower levels of eotaxin compared with D-NAME-treated mice. pimagedine 73-87 chemokine (C-C motif) ligand 2 Mus musculus 147-187 9846976-4 1998 In addition, equivalent numbers of dispersed lung cells from L-NAME- and aminoguanidine-treated mice produced significantly higher levels of IL-4, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1alpha and significantly lower levels of eotaxin compared with D-NAME-treated mice. pimagedine 73-87 chemokine (C-C motif) ligand 3 Mus musculus 193-237 9846976-4 1998 In addition, equivalent numbers of dispersed lung cells from L-NAME- and aminoguanidine-treated mice produced significantly higher levels of IL-4, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1alpha and significantly lower levels of eotaxin compared with D-NAME-treated mice. pimagedine 73-87 chemokine (C-C motif) ligand 11 Mus musculus 272-279 9837854-9 1998 Diarrhea was also blocked by oral aminoguanidine, an inhibitor of NOS II activity. pimagedine 34-48 nitric oxide synthase 2, inducible Mus musculus 66-72 9867208-7 1998 Treatment of diabetic animals with aminoguanidine or NN0028 prevented the depletion in the nNOS-containing neuron number, an effect not reproduced by L-NAME. pimagedine 35-49 nitric oxide synthase 1 Rattus norvegicus 91-95 9820546-3 1998 The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha. pimagedine 27-41 interleukin 1 beta Homo sapiens 201-209 9820546-3 1998 The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha. pimagedine 27-41 tumor necrosis factor Homo sapiens 213-222 9820546-3 1998 The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha. pimagedine 27-41 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 9820546-4 1998 Both aminoguanidine and L-NAME blocked the induction of IL-8 mRNA by LPS. pimagedine 5-19 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 9817691-3 1998 Inhalation of a selective dose of the specific iNOS inhibitor aminoguanidine (0.1 mM, 3 min) had no effect on basal airway reactivity to histamine in unchallenged, ovalbumin-sensitized animals and did not affect the allergen-induced AHR after the EAR. pimagedine 62-76 nitric oxide synthase, inducible Cavia porcellus 47-51 9817691-4 1998 By contrast, this dose of aminoguanidine significantly potentiated the partially reduced AHR after the LAR to the level of AHR observed after the EAR, indicating that induction of iNOS during the LAR contributes to the reversal of AHR. pimagedine 26-40 nitric oxide synthase, inducible Cavia porcellus 180-184 9791050-4 1998 This study investigated whether addition of aminoguanidine, a preferential inducible nitric oxide synthase inhibitor, to glypressin (a long-acting vasopressin analogue) could enhance its portal hypotensive effect in portal-hypertensive rats with bleeding.2. pimagedine 44-58 arginine vasopressin Rattus norvegicus 147-158 9877390-4 1998 This study showed that the expression of inducible nitric oxide synthase and the production of nitric oxide by the tumor can be increased by stimulation with endotoxin lipopolysaccharide and can be inhibited by inducible nitric oxide synthase inhibitors (L-N(g)-monomethyl arginine and aminoguanidine). pimagedine 286-300 nitric oxide synthase 2 Rattus norvegicus 41-72 9870795-5 1998 The lesions were also inhibited by simultaneous administration of N(G)-monomethyl-L-arginine (L-NMMA), and this effect was mimicked by inducible NO synthase (iNOS) inhibitors, such as aminoguanidine or dexamethasone and significantly antagonized by coadministration of L-arginine. pimagedine 184-198 nitric oxide synthase 2 Rattus norvegicus 135-156 9870795-5 1998 The lesions were also inhibited by simultaneous administration of N(G)-monomethyl-L-arginine (L-NMMA), and this effect was mimicked by inducible NO synthase (iNOS) inhibitors, such as aminoguanidine or dexamethasone and significantly antagonized by coadministration of L-arginine. pimagedine 184-198 nitric oxide synthase 2 Rattus norvegicus 158-162 9877390-4 1998 This study showed that the expression of inducible nitric oxide synthase and the production of nitric oxide by the tumor can be increased by stimulation with endotoxin lipopolysaccharide and can be inhibited by inducible nitric oxide synthase inhibitors (L-N(g)-monomethyl arginine and aminoguanidine). pimagedine 286-300 nitric oxide synthase 2 Rattus norvegicus 211-242 9731067-5 1998 When aminoguanidine (AMG), an inhibitor of iNOS, was added during the afferent phase of NK stimulation with IL-12 and TNFalpha, a subsequent increase in the lytic potential of the effector cells towards the NK-sensitive target cells (K562) and lymphokine-activated killer (LAK) target cells (Daudi) was observed. pimagedine 5-19 nitric oxide synthase 2 Homo sapiens 43-47 9810145-4 1998 Pretreatment of rats with iNOS inhibitor aminoguanidine, however, suppressed the development of proximal tubule epithelial cell injury and prevented an increase in blood urea nitrogen and serum creatinine as well as resulting in a marked fall in iNOS mRNA and protein in rats with HgCl2-induced ARF. pimagedine 41-55 nitric oxide synthase 2 Rattus norvegicus 26-30 9810145-4 1998 Pretreatment of rats with iNOS inhibitor aminoguanidine, however, suppressed the development of proximal tubule epithelial cell injury and prevented an increase in blood urea nitrogen and serum creatinine as well as resulting in a marked fall in iNOS mRNA and protein in rats with HgCl2-induced ARF. pimagedine 41-55 nitric oxide synthase 2 Rattus norvegicus 246-250 9806820-2 1998 The decreases in gastric mucosal hexosamine and adherent mucus concentrations were enhanced with a further decrease in gastric mucosal cNOS activity by pretreatment with NG-monomethyl L-arginine, a non-selective NOS inhibitor, but were prevented with maintenance of the gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective inducible NO synthase inhibitor. pimagedine 321-335 nitric oxide synthase 3 Rattus norvegicus 135-139 9806822-3 1998 Aminoguanidine, a selective inducible NO synthase (iNOS) inhibitor, at a dose of 100 mg kg-1 significantly reduced the LPS-induced increase in nitrite levels and improved mortality. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 28-49 9806822-3 1998 Aminoguanidine, a selective inducible NO synthase (iNOS) inhibitor, at a dose of 100 mg kg-1 significantly reduced the LPS-induced increase in nitrite levels and improved mortality. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 51-55 9806822-13 1998 The improvement in sepsis-induced mortality enhanced by aminoguanidine by the inhibition of iNOS but not with the other agents or combinations should be re-evaluated in order to make an appropriate choice of the therapeutic target. pimagedine 56-70 nitric oxide synthase 2, inducible Mus musculus 92-96 9731067-5 1998 When aminoguanidine (AMG), an inhibitor of iNOS, was added during the afferent phase of NK stimulation with IL-12 and TNFalpha, a subsequent increase in the lytic potential of the effector cells towards the NK-sensitive target cells (K562) and lymphokine-activated killer (LAK) target cells (Daudi) was observed. pimagedine 5-19 tumor necrosis factor Homo sapiens 118-126 9731067-5 1998 When aminoguanidine (AMG), an inhibitor of iNOS, was added during the afferent phase of NK stimulation with IL-12 and TNFalpha, a subsequent increase in the lytic potential of the effector cells towards the NK-sensitive target cells (K562) and lymphokine-activated killer (LAK) target cells (Daudi) was observed. pimagedine 21-24 nitric oxide synthase 2 Homo sapiens 43-47 9731067-5 1998 When aminoguanidine (AMG), an inhibitor of iNOS, was added during the afferent phase of NK stimulation with IL-12 and TNFalpha, a subsequent increase in the lytic potential of the effector cells towards the NK-sensitive target cells (K562) and lymphokine-activated killer (LAK) target cells (Daudi) was observed. pimagedine 21-24 tumor necrosis factor Homo sapiens 118-126 9683428-8 1998 Thiocitrulline and aminoguanidine (inhibitors of iNOS) improved contractile responses from LPS-treated wild-type vessels. pimagedine 19-33 nitric oxide synthase 2, inducible Mus musculus 49-53 9776349-7 1998 Antioxidant enzyme systems involved in the glutathione redox cycle, such as glutathione reductase and glutathione peroxidase activities, slightly decreased following aminoguanidine pretreatment. pimagedine 166-180 glutathione-disulfide reductase Rattus norvegicus 76-97 9748524-1 1998 We investigated the temporal profile of the reduction in focal cerebral ischemic damage exerted by aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 99-113 nitric oxide synthase 2 Rattus norvegicus 136-167 9748524-1 1998 We investigated the temporal profile of the reduction in focal cerebral ischemic damage exerted by aminoguanidine (AG), an inhibitor of inducible nitric oxide synthase (iNOS). pimagedine 99-113 nitric oxide synthase 2 Rattus norvegicus 169-173 9865478-4 1998 A dose of 5 mg/kg of aminoguanidine reduced the increase in the platinum level of the LPS-treated mouse, and platinum was no longer detected at doses of 20 mg/kg in the aminoguanidine-injected group. pimagedine 21-35 toll-like receptor 4 Mus musculus 86-89 9724813-7 1998 The iNOS inhibitor aminoguanidine reduced PGE2 concentration in the infarct, where both iNOS and COX-2 were expressed, but not in the olfactory bulb, where only COX-2 was expressed. pimagedine 19-33 nitric oxide synthase 2 Rattus norvegicus 4-8 9724813-7 1998 The iNOS inhibitor aminoguanidine reduced PGE2 concentration in the infarct, where both iNOS and COX-2 were expressed, but not in the olfactory bulb, where only COX-2 was expressed. pimagedine 19-33 nitric oxide synthase 2 Rattus norvegicus 88-92 9724813-7 1998 The iNOS inhibitor aminoguanidine reduced PGE2 concentration in the infarct, where both iNOS and COX-2 were expressed, but not in the olfactory bulb, where only COX-2 was expressed. pimagedine 19-33 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 97-102 9724813-7 1998 The iNOS inhibitor aminoguanidine reduced PGE2 concentration in the infarct, where both iNOS and COX-2 were expressed, but not in the olfactory bulb, where only COX-2 was expressed. pimagedine 19-33 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 161-166 11245022-0 1998 Gene expression of receptor for advanced glycosylation end products and its modulation by aminoguanidine in diabetic kidney tissue. pimagedine 90-104 advanced glycosylation end product-specific receptor Rattus norvegicus 19-67 9700141-4 1998 Both eNOS and iNOS were suppressed by L-NAME, whereas iNOS alone was inhibited by aminoguanidine. pimagedine 82-96 nitric oxide synthase 2 Rattus norvegicus 54-58 9717976-0 1998 Aminoguanidine reduces glomerular inducible nitric oxide synthase (iNOS) and transforming growth factor-beta 1 (TGF-beta1) mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 34-65 9717976-0 1998 Aminoguanidine reduces glomerular inducible nitric oxide synthase (iNOS) and transforming growth factor-beta 1 (TGF-beta1) mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 67-71 9717976-0 1998 Aminoguanidine reduces glomerular inducible nitric oxide synthase (iNOS) and transforming growth factor-beta 1 (TGF-beta1) mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice. pimagedine 0-14 transforming growth factor, beta 1 Mus musculus 77-110 9717976-0 1998 Aminoguanidine reduces glomerular inducible nitric oxide synthase (iNOS) and transforming growth factor-beta 1 (TGF-beta1) mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice. pimagedine 0-14 transforming growth factor, beta 1 Mus musculus 112-121 9717976-2 1998 The aim of this study was to evaluate the effect of aminoguanidine, a selective inhibitor of iNOS, for the protection from glomerulosclerosis in NZB/W F1 mice. pimagedine 52-66 nitric oxide synthase 2, inducible Mus musculus 93-97 9717976-5 1998 By glomerular microdissection and reverse-transcription competitive polymerase chain reaction, we found that glomerular iNOS/beta-actin and TGF-beta1/beta-actin mRNA ratios were reduced 15.1% (P<0.05) and 61.3% (P<0.01), respectively, in aminoguanidine-treated mice. pimagedine 244-258 nitric oxide synthase 2, inducible Mus musculus 120-124 9717976-6 1998 Aminoguanidine significantly reduced the glomerular iNOS staining, urinary nitrite production and degree of glomerulosclerosis. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 52-56 9718006-1 1998 BACKGROUND: The role of inducible nitric oxide synthase (iNOS) in endotoxin-induced bacterial translocation was investigated by using its specific blocker aminoguanidine in 46 albino mice (25-35 g) allocated into four groups. pimagedine 155-169 nitric oxide synthase 2, inducible Mus musculus 57-61 9718006-9 1998 CONCLUSION: The inhibition of iNOS during endotoxaemia by its specific blocker aminoguanidine attenuates the incidence of bacterial translocation in mice. pimagedine 79-93 nitric oxide synthase 2, inducible Mus musculus 30-34 9667497-5 1998 Allograft recipients received daily injections of PDTC or aminoguanidine (a known inhibitor of iNOS). pimagedine 58-72 nitric oxide synthase 2 Homo sapiens 95-99 9712555-8 1998 The elevated ileal nitric oxide synthase activity was significantly reduced by pretreatment with the iNOS inhibitor, aminoguanidine. pimagedine 117-131 nitric oxide synthase 2 Rattus norvegicus 101-105 9691088-5 1998 Inhibition of iNOS activity by aminoguanidine also attenuates TNF + LPS + IFN-gamma-induced inhibition of insulin secretion by human islets. pimagedine 31-45 nitric oxide synthase 2 Homo sapiens 14-18 9691088-5 1998 Inhibition of iNOS activity by aminoguanidine also attenuates TNF + LPS + IFN-gamma-induced inhibition of insulin secretion by human islets. pimagedine 31-45 tumor necrosis factor Homo sapiens 62-65 9691088-5 1998 Inhibition of iNOS activity by aminoguanidine also attenuates TNF + LPS + IFN-gamma-induced inhibition of insulin secretion by human islets. pimagedine 31-45 interferon gamma Homo sapiens 74-83 9691088-5 1998 Inhibition of iNOS activity by aminoguanidine also attenuates TNF + LPS + IFN-gamma-induced inhibition of insulin secretion by human islets. pimagedine 31-45 insulin Homo sapiens 106-113 9670045-9 1998 Finally, treatment of rats with two structurally distinct inhibitors of polyamine oxidase (aminoguanidine and chloroquine) attenuates brain polyamine oxidase activity, prevents the production of 3-aminopropanal, and significantly protects against the development of ischemic brain damage in vivo. pimagedine 91-105 polyamine oxidase Rattus norvegicus 72-89 9670045-9 1998 Finally, treatment of rats with two structurally distinct inhibitors of polyamine oxidase (aminoguanidine and chloroquine) attenuates brain polyamine oxidase activity, prevents the production of 3-aminopropanal, and significantly protects against the development of ischemic brain damage in vivo. pimagedine 91-105 polyamine oxidase Rattus norvegicus 140-157 9713511-8 1998 It occurs mostly through type I (p55) TNF receptors, probably involves a calphostin-C sensitive protein kinase C activity and requires synthesis of proteins (it is inhibited by actinomycin D or cycloheximide) and of inducible nitric oxide (NO) synthase (it is inhibited by NG-methyl-L-arginine or aminoguanidine). pimagedine 297-311 TNF receptor superfamily member 1A Homo sapiens 33-36 9713511-8 1998 It occurs mostly through type I (p55) TNF receptors, probably involves a calphostin-C sensitive protein kinase C activity and requires synthesis of proteins (it is inhibited by actinomycin D or cycloheximide) and of inducible nitric oxide (NO) synthase (it is inhibited by NG-methyl-L-arginine or aminoguanidine). pimagedine 297-311 tumor necrosis factor Homo sapiens 38-41 9672075-9 1998 Treatment with 25 mmol/L aminoguanidine, an antioxidant and inhibitor of the formation of advanced glycation end products, during glycation normalized glycated LDL-induced generation of PAI-1 and tPA in ECs. pimagedine 25-39 serpin family E member 1 Homo sapiens 186-191 9672075-9 1998 Treatment with 25 mmol/L aminoguanidine, an antioxidant and inhibitor of the formation of advanced glycation end products, during glycation normalized glycated LDL-induced generation of PAI-1 and tPA in ECs. pimagedine 25-39 chromosome 20 open reading frame 181 Homo sapiens 196-199 9717668-5 1998 NO generation was significantly reduced when cells were cotreated with the competitive iNOS inhibitor aminoguanidine. pimagedine 102-116 nitric oxide synthase 2 Rattus norvegicus 87-91 9648854-3 1998 The NOS inhibitors N-monomethylarginine, aminoguanidine, and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine.HCl prevented TNF-alpha/LPS-induced cell death and DNA fragmentation, suggesting that the TNF-alpha/LPS-induced cell death is mediated by iNOS-derived NO. pimagedine 41-55 tumor necrosis factor Rattus norvegicus 120-129 9626296-6 1998 The increase in rCBF was attenuated by systemic administration of the selective iNOS inhibitor aminoguanidine (100 mg/kg IP) or the selective COX-2 inhibitor NS-398 (5 mg/kg IP), and it was abolished by preventing induction of these isoforms with dexamethasone (4 mg/kg IP). pimagedine 95-109 CCAAT/enhancer binding protein zeta Rattus norvegicus 16-20 9626296-6 1998 The increase in rCBF was attenuated by systemic administration of the selective iNOS inhibitor aminoguanidine (100 mg/kg IP) or the selective COX-2 inhibitor NS-398 (5 mg/kg IP), and it was abolished by preventing induction of these isoforms with dexamethasone (4 mg/kg IP). pimagedine 95-109 nitric oxide synthase 2 Rattus norvegicus 80-84 9626296-8 1998 The increases in iNOS and cyclooxygenase enzyme activity were eliminated by aminoguanidine and NS-398, respectively. pimagedine 76-90 nitric oxide synthase 2 Rattus norvegicus 17-21 9751155-8 1998 Aminoguanidine, a NOS inhibitor with relatively greater selectivity for the inducible NOS (iNOS) isoform, reversed nerve hyperaemia distal to the constriction only at 14 days. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 76-89 20654405-6 1998 Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively. pimagedine 0-14 polyamine oxidase Rattus norvegicus 82-99 20654405-6 1998 Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively. pimagedine 0-14 polyamine oxidase Rattus norvegicus 101-104 20654405-6 1998 Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively. pimagedine 0-14 amine oxidase, copper containing 3 Rattus norvegicus 110-147 20654405-6 1998 Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively. pimagedine 0-14 amine oxidase, copper containing 3 Rattus norvegicus 149-153 9593776-7 1998 Pretreatment with dexamethasone or with aminoguanidine, an inhibitor of inducible nitric oxide synthase, prevented the IL-1beta-induced myocardial dysfunction. pimagedine 40-54 interleukin 1 beta Canis lupus familiaris 119-127 9593776-8 1998 Nitrotyrosine concentration, an in vivo marker of the peroxynitrite production by nitric oxide and superoxide anion, was significantly higher in the myocardium of the IL-1beta group than in that of the control group or the group cotreated with dexamethasone or aminoguanidine. pimagedine 261-275 interleukin 1 beta Canis lupus familiaris 167-175 9751155-8 1998 Aminoguanidine, a NOS inhibitor with relatively greater selectivity for the inducible NOS (iNOS) isoform, reversed nerve hyperaemia distal to the constriction only at 14 days. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 91-95 9538001-0 1998 Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine. pimagedine 61-75 nitric oxide synthase 2 Homo sapiens 13-44 9667074-2 1998 Pretreatment with aminoguanidine (100 mg/kg), a relatively selective iNOS inhibitor, attenuated not only gastric mucosal lesion development, but also increases in serum and gastric mucosal nitrite/nitrate concentrations with inhibition of increased gastric mucosal iNOS activity in rats with 6 h of WIR stress. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 69-73 9667074-2 1998 Pretreatment with aminoguanidine (100 mg/kg), a relatively selective iNOS inhibitor, attenuated not only gastric mucosal lesion development, but also increases in serum and gastric mucosal nitrite/nitrate concentrations with inhibition of increased gastric mucosal iNOS activity in rats with 6 h of WIR stress. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 265-269 9706484-5 1998 We found that: GM3 induced NO production by macrophages in a time- and dose-dependent manner; GM3 and IFN-gamma synergistically increased NO production; GM3 markedly enhanced MTC; both NO production and MTC were significantly inhibited by aminoguanidine. pimagedine 239-253 granulocyte macrophage antigen 3 Mus musculus 15-18 9706484-5 1998 We found that: GM3 induced NO production by macrophages in a time- and dose-dependent manner; GM3 and IFN-gamma synergistically increased NO production; GM3 markedly enhanced MTC; both NO production and MTC were significantly inhibited by aminoguanidine. pimagedine 239-253 granulocyte macrophage antigen 3 Mus musculus 94-97 9706484-5 1998 We found that: GM3 induced NO production by macrophages in a time- and dose-dependent manner; GM3 and IFN-gamma synergistically increased NO production; GM3 markedly enhanced MTC; both NO production and MTC were significantly inhibited by aminoguanidine. pimagedine 239-253 interferon gamma Mus musculus 102-111 9706484-5 1998 We found that: GM3 induced NO production by macrophages in a time- and dose-dependent manner; GM3 and IFN-gamma synergistically increased NO production; GM3 markedly enhanced MTC; both NO production and MTC were significantly inhibited by aminoguanidine. pimagedine 239-253 granulocyte macrophage antigen 3 Mus musculus 94-97 9538001-1 1998 The inducible nitric oxide synthase (iNOS) selective inhibitors aminoguanidine (AG) and N6-(1-iminoethyl)-L-lysine (NIL), under conditions that support catalytic turnover, inactivate the enzyme by altering in different ways the functionality of the active site. pimagedine 64-78 nitric oxide synthase 2 Homo sapiens 4-35 9538001-1 1998 The inducible nitric oxide synthase (iNOS) selective inhibitors aminoguanidine (AG) and N6-(1-iminoethyl)-L-lysine (NIL), under conditions that support catalytic turnover, inactivate the enzyme by altering in different ways the functionality of the active site. pimagedine 64-78 nitric oxide synthase 2 Homo sapiens 37-41 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). pimagedine 287-301 interleukin 1 beta Rattus norvegicus 157-165 9628258-7 1998 This is why selective iNOS inhibitors like aminoguanidine or thiourea derivatives might be preferred over nonselective NOS inhibitors for the treatment of septic shock. pimagedine 43-57 nitric oxide synthase 2 Homo sapiens 22-26 9565258-2 1998 We further hypothesized that treatment with aminoguanidine (AG; 50 mg/kg), a selective iNOS inhibitor, would decrease NO production and alter blood flow. pimagedine 44-58 nitric oxide synthase 2 Rattus norvegicus 87-91 9559657-2 1998 This increase in gastric mucosal MPO activity was enhanced by pretreatment with NG-monomethyl L-arginine, a non-selective NOS inhibitor, but was prevented with maintenance of gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective iNOS inhibitor. pimagedine 226-240 myeloperoxidase Rattus norvegicus 33-36 9535016-9 1998 The ability of the selective inducible (iNOS) inhibitor, aminoguanidine, but not the selective "neuronal-type" constitutive (cNOS) inhibitor 7-nitroindazole, to inhibit NO production suggested a primary role of iNOS in this response and was confirmed by immunolabelling of activated cells with a specific iNOS antibody. pimagedine 57-71 nitric oxide synthase 2, inducible Mus musculus 40-44 9480941-12 1998 To test for a possible involvement of inducible NO synthase (iNOS) in sepsis-induced attenuated ACh responses, arterioles and capillaries in septic animals were locally pretreated with the iNOS blocker aminoguanidine (10 mM). pimagedine 202-216 nitric oxide synthase 2 Rattus norvegicus 189-193 9500703-9 1998 Production of nitric oxide by cells from both control and acetaminophen-treated rats was blocked by aminoguanidine, a relatively specific inhibitor of iNOS. pimagedine 100-114 nitric oxide synthase 2 Rattus norvegicus 151-155 9500703-10 1998 Arginine uptake and metabolism studies revealed that the inhibitory effects of aminoguanidine were due predominantly to inhibition of iNOS enzyme activity. pimagedine 79-93 nitric oxide synthase 2 Rattus norvegicus 134-138 9498449-3 1998 Animals treated with iNOS inhibitor aminoguanidine (AG; 130 mg/kg every 8 h) had reduced NO production (P < .05), higher CSF bacterial titers (P < .05), and increased incidence of seizures (P < .01) compared with untreated infected animals. pimagedine 36-50 nitric oxide synthase 2 Homo sapiens 21-25 9489756-8 1998 Addition of aminoguanidine, which inhibits DAO enzyme activity, did not inhibit the protein"s neurotrophic activity. pimagedine 12-26 D-amino-acid oxidase Gallus gallus 43-46 9585809-4 1998 L-NMMA and aminoguanidine, competitive inhibitors of iNOS suppressed NO production as measured by the NO byproduct, nitrite, as did IFN-B. pimagedine 11-25 nitric oxide synthase 2 Homo sapiens 53-57 9585809-4 1998 L-NMMA and aminoguanidine, competitive inhibitors of iNOS suppressed NO production as measured by the NO byproduct, nitrite, as did IFN-B. pimagedine 11-25 interferon beta 1 Homo sapiens 132-137 9645394-3 1998 The inhibitors of the iNOS pathway, aminoguanidine and NG-monomethyl-L-arginine (L-NMMA), suppressed the production of .NO and enhanced the steady-state concentration of O2.- determined. pimagedine 36-50 nitric oxide synthase 2 Homo sapiens 22-26 9512406-4 1998 This increase was blocked by alpha-phenyl-tert-butyl-nitrone, a free radical scavenger, and by aminoguanidine, an inhibitor of NOS 2. pimagedine 95-109 nitric oxide synthase 2 Rattus norvegicus 127-132 9645394-6 1998 In differentiated U937 (or THP-1) cells, IgG or IgE-opsonized zymosan induced a strong time-dependent luminol-dependent chemiluminescence (LDCL), which was abrogated by SOD and partially inhibited by aminoguanidine or L-NMMA. pimagedine 200-214 superoxide dismutase 1 Homo sapiens 169-172 9527404-0 1998 Aminoguanidine inhibits advanced glycation end products formation on beta2-microglobulin. pimagedine 0-14 beta-2-microglobulin Homo sapiens 69-88 9453609-5 1998 Cultures of RAW264.7 cells treated with IFN-gamma plus lipopolysaccharide exhibited suppression of the initial rickettsial infection, and the suppression was relieved by aminoguanidine. pimagedine 170-184 interferon gamma Mus musculus 40-49 9446547-5 1998 All the transgenic mice developed hypoinsulinemic diabetes by 4 weeks of age, and treatment with an inhibitor of NOS2, aminoguanidine (200 mg/kg body weight every 12 h), prevented or delayed the development of diabetes. pimagedine 119-133 nitric oxide synthase 2, inducible Mus musculus 113-117 9488156-5 1998 The CHS response was also reduced by aminoguanidine, which is known to preferentially inhibit the inducible isoform of the enzyme (iNOS), suggesting that iNOS contributed to the inflammatory response. pimagedine 37-51 nitric oxide synthase 2, inducible Mus musculus 131-135 9472897-9 1998 Coapplication of either aminoguanidine or dexamethasone with TNFalpha prevented dilatation of cerebral arterioles compared with TNFalpha alone (4+/-2% and 1+/-1% dilatation at 4 hours, respectively; P<.05). pimagedine 24-38 tumor necrosis factor Rattus norvegicus 128-136 9472897-15 1998 Inhibition of TNFalpha-induced dilatation by aminoguanidine and dexamethasone suggests that the vasodilatation was due predominantly to expression of inducible NO synthase. pimagedine 45-59 tumor necrosis factor Rattus norvegicus 14-22 9472897-15 1998 Inhibition of TNFalpha-induced dilatation by aminoguanidine and dexamethasone suggests that the vasodilatation was due predominantly to expression of inducible NO synthase. pimagedine 45-59 nitric oxide synthase 2 Rattus norvegicus 150-171 9488173-3 1998 In addition, 4VO produced a gradual increase in hippocampal NO2- and NO3- levels over a 24 h period after reperfusion, which was abolished by an inducible NO synthase inhibitor, aminoguanidine (10 mg/kg, intraperitoneally). pimagedine 178-192 nitric oxide synthase 2 Rattus norvegicus 145-166 9449384-1 1998 In the present studies, the influence of inducible nitric oxide synthase (NOS) inhibition with aminoguanidine on renal function and blood pressure was examined in rats. pimagedine 95-109 nitric oxide synthase 2 Rattus norvegicus 41-72 9495580-3 1998 METHODS: Aminoguanidine (AMG), a selective inhibitor of inducible nitric oxide synthase (iNOS) was used to determine the role of nitric oxide (NO) in the fatalities. pimagedine 9-23 nitric oxide synthase 2, inducible Mus musculus 89-93 11253800-8 1998 In the presence of aminoguanidine, a adenosine deaminase inhibitor (10 mM or 10 n mol/microl/min), the elevation of inosine was not observed. pimagedine 19-33 adenosine deaminase Rattus norvegicus 37-56 21781848-2 1998 Aminoguanidine, a competitive inhibitor of inducible NO synthase (iNOS), when administered s.c. at 5 mg/kg, but not 500 mg/kg, reduced significantly the increase in brain fluorescein level after its i.v. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 43-64 21781848-2 1998 Aminoguanidine, a competitive inhibitor of inducible NO synthase (iNOS), when administered s.c. at 5 mg/kg, but not 500 mg/kg, reduced significantly the increase in brain fluorescein level after its i.v. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 66-70 9488156-5 1998 The CHS response was also reduced by aminoguanidine, which is known to preferentially inhibit the inducible isoform of the enzyme (iNOS), suggesting that iNOS contributed to the inflammatory response. pimagedine 37-51 nitric oxide synthase 2, inducible Mus musculus 154-158 9851362-5 1998 In addition, the above-mentioned changes in iNOS activity and LPO and NP-SH concentrations with lesion development in the gastric mucosa of rats with WIR stress were attenuated with both prevention of the lesion development and an increase in the concentration of gastric mucosal nitrite/nitrate, the breakdown products of NO, by pretreatment with aminoguanidine, a selective iNOS inhibitor. pimagedine 348-362 nitric oxide synthase 2 Rattus norvegicus 44-48 9521623-0 1998 Aminoguanidine, a selective inhibitor of the inducible nitric oxide synthase, has different effects on experimental allergic encephalomyelitis in the induction and progression phase. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 45-76 9388501-7 1997 Inhibitors of NO, L-NG-monomethyl L-arginine, and aminoguanidine partially restored cell proliferation and collagen synthesis in cells exposed to LPS and IFN gamma. pimagedine 50-64 interferon gamma Homo sapiens 154-163 9399944-4 1997 Treatment with aminoguanidine, a preferential inhibitor of inducible nitric oxide synthase, was associated with enhanced proliferation of alpha-smooth muscle actin immunoreactive cells and the intensity of obliterative bronchiolitis early after transplantation. pimagedine 15-29 nitric oxide synthase 2 Rattus norvegicus 59-90 9399944-5 1997 Aminoguanidine treatment did not affect iNOS mRNA synthesis or intragraft nitric oxide production, but decreased iNOS immunoreactivity in smooth muscle cells. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 113-117 9808068-6 1998 We found that LPS (10-500 ng/ml) induced a concentration-dependent increase in the production of NO which was abolished by the selective iNOS inhibitor aminoguanidine. pimagedine 152-166 nitric oxide synthase 2 Homo sapiens 137-141 9401586-2 1997 administration of histamine were monitored in the anaesthetized rat in the absence or presence of the diamine oxidase (DAO) inhibitor aminoguanidine (AMG, 10 mg kg-1). pimagedine 134-148 amine oxidase, copper containing 1 Rattus norvegicus 119-122 9386181-5 1997 We inhibited both eNOS and iNOS activity by cotreatment with L-NAME (a nonspecific inhibitor of NOS) and iNOS activity alone by aminoguanidine (a selective inhibitor of iNOS). pimagedine 128-142 nitric oxide synthase 2 Sus scrofa 105-109 9386181-5 1997 We inhibited both eNOS and iNOS activity by cotreatment with L-NAME (a nonspecific inhibitor of NOS) and iNOS activity alone by aminoguanidine (a selective inhibitor of iNOS). pimagedine 128-142 nitric oxide synthase 2 Sus scrofa 105-109 9396926-11 1997 Nitric oxide-dependent cyclooxygenase-2 and inducible nitric oxide synthase expression was demonstrated by the elimination of accumulation of both messenger ribonucleic acid transcripts in mice pretreated with aminoguanidine before injection with lipopolysaccharide. pimagedine 210-224 prostaglandin-endoperoxide synthase 2 Mus musculus 23-39 9396926-11 1997 Nitric oxide-dependent cyclooxygenase-2 and inducible nitric oxide synthase expression was demonstrated by the elimination of accumulation of both messenger ribonucleic acid transcripts in mice pretreated with aminoguanidine before injection with lipopolysaccharide. pimagedine 210-224 nitric oxide synthase 2, inducible Mus musculus 44-75 9408610-4 1997 This treatment suppressed tumor growth (or killed tumor cells) and increased the long-term survival of animals (at least 80 days) without tumors, which was prevented by simultaneous treatment of iNOS inhibitor aminoguanidine. pimagedine 210-224 nitric oxide synthase 2, inducible Mus musculus 195-199 9374708-4 1997 The relaxant response to L-Arg in iNOS-induced CM tissues was blocked by the iNOS inhibitor aminoguanidine and by the guanylyl cyclase inhibitor LY-83583. pimagedine 92-106 nitric oxide synthase 2 Rattus norvegicus 34-38 9374708-4 1997 The relaxant response to L-Arg in iNOS-induced CM tissues was blocked by the iNOS inhibitor aminoguanidine and by the guanylyl cyclase inhibitor LY-83583. pimagedine 92-106 nitric oxide synthase 2 Rattus norvegicus 77-81 9401792-19 1997 Aminoguanidine, a specific inhibitor for inducible NO synthase (iNOS), in dose 10-60 mg kg-1 i.v. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 41-62 9401792-19 1997 Aminoguanidine, a specific inhibitor for inducible NO synthase (iNOS), in dose 10-60 mg kg-1 i.v. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 64-68 9347312-10 1997 Aminoguanidine may reduce the blood flow to the pancreatic islets in vivo and, at higher concentrations, also impair insulin secretion by the beta-cells,--which may make the compound less useful in attempts to prevent insulin-dependent diabetes mellitus. pimagedine 0-14 insulin Homo sapiens 117-124 9389414-3 1997 We have found that aminoguanidine is also quite potent at inhibiting semicarbazide-sensitive amine oxidase (SSAO) both in vitro and in vivo. pimagedine 19-33 amine oxidase, copper containing 3 Rattus norvegicus 108-112 9336332-4 1997 Of the aminoguanidines examined, 2-ethylaminoguanidine was the most efficient inactivator, exhibiting vs. iNOS an apparent KI value of 120 microM as measured at 100 microM arginine and a k(inact max) value of 0.48 min(-1) and thus an apparent second-order rate constant for inactivation of 4.0 mM(-1)min(-1). pimagedine 7-22 nitric oxide synthase 2, inducible Mus musculus 106-110 9322519-9 1997 Treatment with the selective iNOS inhibitor, aminoguanidine, inhibited iNOS enzymatic activity and overproduction of NO2-/NO3-. pimagedine 45-59 nitric oxide synthase 2 Rattus norvegicus 29-33 9322519-9 1997 Treatment with the selective iNOS inhibitor, aminoguanidine, inhibited iNOS enzymatic activity and overproduction of NO2-/NO3-. pimagedine 45-59 nitric oxide synthase 2 Rattus norvegicus 71-75 9425624-3 1997 Gastric lesions induced by 5-HT were prevented by simultaneous administration of aminoguanidine, a selective inducible NO synthase (iNOS) inhibitor, as well as by methysergide, a 5-HT antagonist. pimagedine 81-95 nitric oxide synthase 2 Rattus norvegicus 109-130 9425624-3 1997 Gastric lesions induced by 5-HT were prevented by simultaneous administration of aminoguanidine, a selective inducible NO synthase (iNOS) inhibitor, as well as by methysergide, a 5-HT antagonist. pimagedine 81-95 nitric oxide synthase 2 Rattus norvegicus 132-136 9336332-9 1997 1-Amino-S-methylisothiourea by contrast with the aminoguanidines was identified as a mechanism-based inactivator selective for the nNOS isoform. pimagedine 49-64 nitric oxide synthase 1, neuronal Mus musculus 131-135 9316465-5 1997 Pretreatment with the selective iNOS inhibitor aminoguanidine further doubled TNF-alpha-induced leukocyte rolling. pimagedine 47-61 nitric oxide synthase 2 Homo sapiens 32-36 9369379-6 1997 The suppressive effect of TNF-alpha on lipoprotein lipase activity was significantly prevented by NO synthase inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and aminoguanidine, but not by D-NAME, an inactive isomer. pimagedine 168-182 tumor necrosis factor Homo sapiens 26-35 9369379-6 1997 The suppressive effect of TNF-alpha on lipoprotein lipase activity was significantly prevented by NO synthase inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and aminoguanidine, but not by D-NAME, an inactive isomer. pimagedine 168-182 lipoprotein lipase Homo sapiens 39-57 9316465-5 1997 Pretreatment with the selective iNOS inhibitor aminoguanidine further doubled TNF-alpha-induced leukocyte rolling. pimagedine 47-61 tumor necrosis factor Homo sapiens 78-87 9277445-5 1997 .NO formation is inhibited by 28-46% by three inhibitors of cNOS and inducible NOS (iNOS), NG-monomethyl-L-arginine (L-NMMA), L-N5-(1-iminoethyl)ornithine hydrochloride, and NG-nitro-L-arginine methyl ester, but a specific inhibitor of iNOS, aminoguanidine, has no effect. pimagedine 242-256 nitric oxide synthase 3 Homo sapiens 60-64 9277445-5 1997 .NO formation is inhibited by 28-46% by three inhibitors of cNOS and inducible NOS (iNOS), NG-monomethyl-L-arginine (L-NMMA), L-N5-(1-iminoethyl)ornithine hydrochloride, and NG-nitro-L-arginine methyl ester, but a specific inhibitor of iNOS, aminoguanidine, has no effect. pimagedine 242-256 nitric oxide synthase 2 Homo sapiens 84-88 9231653-13 1997 IL-1beta caused appreciable damage to mtDNA, and this damage was reduced in mtDNA from cultures treated with IL-1beta and aminoguanidine. pimagedine 122-136 interleukin 1 beta Rattus norvegicus 0-8 9279254-3 1997 We examined the effects of NO synthase (NOS) induction by LPS on vascular reactivity of the isolated perfused rat lung (IPL) using the selective inducible (iNOS) inhibitor aminoguanidine (AG). pimagedine 172-186 nitric oxide synthase 2 Rattus norvegicus 156-160 9258227-0 1997 An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia. pimagedine 34-48 vascular endothelial growth factor A Rattus norvegicus 57-91 9252133-9 1997 In addition, administration of aminoguanidine (AG), a preferential iNOS inhibitor, elevated dose-dependently mean arterial pressure in both groups, but this increase was greater in BDL (26.5 +/- 4.4 mm hg) than in SO (13.6 +/- 2.6). pimagedine 31-45 nitric oxide synthase 2 Rattus norvegicus 67-71 9252133-13 1997 The amelioration of the arterial hypotension and the associated reduced excretory levels of these cirrhotic animals by aminoguanidine further support the involvement of the inducible NO synthase isoform in the renal alterations observed in BDL animals. pimagedine 119-133 nitric oxide synthase 2 Rattus norvegicus 173-194 9186887-3 1997 Pretreatment with aminoguanidine or dexamethasone, inhibitors of inducible NO synthase (iNOS), prevented the increase in UNOXV and UcGMPV but had no impact on mean arterial pressure (BP), renal vascular resistance (RVR) or GFR. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 65-86 9218505-4 1997 In vivo nicotinamide or aminoguanidine treatment of prediabetic ZDF rats prevented the iNOS expression in islets and decreased beta cell dysfunction while blocking beta cell destruction and hyperglycemia. pimagedine 24-38 nitric oxide synthase 2 Rattus norvegicus 87-91 9249471-7 1997 Direct iNOS inhibition with aminoguanidine inhibited NO production and prevented allograft contractile and electrophysiological dysfunction (e.g., tension of 64 mN/mm2 during calcium stimulation, P < 0.001). pimagedine 28-42 nitric oxide synthase 2 Rattus norvegicus 7-11 9306416-4 1997 Amino-guanidine inhibiting inducible NO synthase had no effect on the diarrhea, but dexamethasone, an inhibitor of both inducible NO synthase and phospholipase A2 that synthesizes PGs, significantly prevented it. pimagedine 0-15 nitric oxide synthase 2 Rattus norvegicus 27-48 9240424-4 1997 Pretreatment with aminoguanidine, a selective iNOS inhibitor, prevented gastric mucosal lesion development with inhibition of iNOS activity and maintenance of cNOS activity in the gastric mucosa. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 46-50 9240424-4 1997 Pretreatment with aminoguanidine, a selective iNOS inhibitor, prevented gastric mucosal lesion development with inhibition of iNOS activity and maintenance of cNOS activity in the gastric mucosa. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 126-130 9240424-4 1997 Pretreatment with aminoguanidine, a selective iNOS inhibitor, prevented gastric mucosal lesion development with inhibition of iNOS activity and maintenance of cNOS activity in the gastric mucosa. pimagedine 18-32 nitric oxide synthase 3 Rattus norvegicus 159-163 9218489-7 1997 N-Acetyl-L-cysteine and aminoguanidine suppressed both dicarbonyl-increased HB-EGF mRNA and intracellular peroxide levels in RASMC. pimagedine 24-38 heparin-binding EGF-like growth factor Rattus norvegicus 76-82 9186887-3 1997 Pretreatment with aminoguanidine or dexamethasone, inhibitors of inducible NO synthase (iNOS), prevented the increase in UNOXV and UcGMPV but had no impact on mean arterial pressure (BP), renal vascular resistance (RVR) or GFR. pimagedine 18-32 nitric oxide synthase 2 Rattus norvegicus 88-92 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. pimagedine 239-253 nitric oxide synthase 2 Rattus norvegicus 0-4 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. pimagedine 239-253 interferon gamma Rattus norvegicus 85-94 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. pimagedine 239-253 interleukin 1 beta Rattus norvegicus 111-119 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. pimagedine 239-253 nitric oxide synthase 2 Rattus norvegicus 224-228 9195135-8 1997 The efficacy of S-methyl-L-thiocitrulline, NG-monomethyl-L-arginine and aminoguanidine in counteracting IL-1 beta induced nitrite formation was also compared. pimagedine 72-86 interleukin 1 beta Mus musculus 104-113 9133470-6 1997 Allografts had significantly impaired gas exchange, which was prevented with the selective iNOS inhibitor aminoguanidine (PaO2 of 566+/-19, 76+/-22, and 504+/-105 mmHg for isograft, allograft, and aminoguanidine-treated allograft, respectively; P<0.0002). pimagedine 106-120 nitric oxide synthase 2 Rattus norvegicus 91-95 9176264-5 1997 The .NO synthase inhibitor aminoguanidine (100 microM) prevented the TNF-alpha-induced increase in NO2-, nitrotyrosine immunofluorescence, oxidized p42, and permeability. pimagedine 27-41 tumor necrosis factor Homo sapiens 69-78 9176264-5 1997 The .NO synthase inhibitor aminoguanidine (100 microM) prevented the TNF-alpha-induced increase in NO2-, nitrotyrosine immunofluorescence, oxidized p42, and permeability. pimagedine 27-41 erythrocyte membrane protein band 4.2 Homo sapiens 148-151 9176264-6 1997 Coincubation with L-arginine (200 microM) or the .NO mimic spermine-NO (1 microM) prevented the ablation of the response to TNF-alpha by aminoguanidine. pimagedine 137-151 tumor necrosis factor Homo sapiens 124-133 9151791-4 1997 Blood flow and albumin permeation were increased approximately 2.5-fold 1 h after topical application of recombinant human VEGF and these effects were prevented by nitric oxide synthase (NOS) inhibitors (aminoguanidine and N(G)-monomethyl L-arginine). pimagedine 204-218 vascular endothelial growth factor A Homo sapiens 123-127 9151791-4 1997 Blood flow and albumin permeation were increased approximately 2.5-fold 1 h after topical application of recombinant human VEGF and these effects were prevented by nitric oxide synthase (NOS) inhibitors (aminoguanidine and N(G)-monomethyl L-arginine). pimagedine 204-218 nitric oxide synthase 2 Homo sapiens 164-185 9151791-6 1997 Application of sodium nitroprusside for 7 d or the single application of a calcium ionophore, A23187, mimicked effects of glucose, sorbitol, and VEGF on vascular dysfunction and the ionophore effect was prevented by coadministration of aminoguanidine. pimagedine 236-250 vascular endothelial growth factor A Rattus norvegicus 145-149 9128284-10 1997 Dexamethasone or aminoguanidine attenuated the effects of LPS suggesting the involvement of iNOS in these responses. pimagedine 17-31 nitric oxide synthase 2 Rattus norvegicus 92-96 9112415-8 1997 The iNOS selective inhibitor aminoguanidine suppressed stimulated osteoclast NO production elicited by either signal, but reversed only the resorption inhibition due to raised Ca2+. pimagedine 29-43 nitric oxide synthase 2 Homo sapiens 4-8 9094680-7 1997 Mice treated with antibody against IL-1beta or TNF-alpha or with the iNOS inhibitor aminoguanidine exhibited a significant decrease in the incidence of diabetes. pimagedine 84-98 nitric oxide synthase 2, inducible Mus musculus 69-73 9133470-8 1997 CONCLUSIONS: (1) iNOS expression and increased NO production occurred during the early stages of acute rejection, persisted throughout the unmodified rejection process, and localized to infiltrating inflammatory cells, but not allograft parenchymal cells; (2) aminoguanidine ameliorated the histological and functional changes of acute rejection; and (3) increased NO production, detected by the presence of iNOS mRNA, protein, or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection. pimagedine 260-274 nitric oxide synthase 2 Rattus norvegicus 17-21 9113364-13 1997 Administration of NG-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine to rats significantly reduced cellular NOS activity, NO2/NO3- levels and chemiluminescence, whereas they were without effect on cell migration and degranulation, eicosanoid levels and sPLA2 activity. pimagedine 63-77 phospholipase A2 group IIA Rattus norvegicus 262-267 9083027-3 1997 Aminoguanidine and mercaptoethylguanidine (MEG) are inhibitors of iNOS and have anti-inflammatory properties. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 66-70 9062360-9 1997 Treatment of diabetic rats with aminoguanidine resulted in significant amelioration of the described pathological changes including overexpression of TGF-beta1 and alpha1 (IV) collagen. pimagedine 32-46 transforming growth factor, beta 1 Rattus norvegicus 150-159 9105885-1 1997 We investigated the effects of aminoguanidine, a relatively selective inhibitor of inducible nitric oxide (NO) synthase, on the systemic inflammatory response syndrome induced by platelet activating factor (PAF) and by lipopolysaccharide in rats, with emphasis on NO production in vivo. pimagedine 31-45 PCNA clamp associated factor Rattus norvegicus 179-205 9105885-1 1997 We investigated the effects of aminoguanidine, a relatively selective inhibitor of inducible nitric oxide (NO) synthase, on the systemic inflammatory response syndrome induced by platelet activating factor (PAF) and by lipopolysaccharide in rats, with emphasis on NO production in vivo. pimagedine 31-45 PCNA clamp associated factor Rattus norvegicus 207-210 9032354-12 1997 In addition, treatment of OBLV60-infected BALB/c mice with aminoguanidine, a selective inhibitor of iNOS activity, did not result in any increase in mortality, and the mice cleared the virus by 11 days p.i. pimagedine 59-73 nitric oxide synthase 2, inducible Mus musculus 100-104 8977420-9 1997 Treatment with aminoguanidine, an inhibitor of inducible nitric oxide synthase, led to augmentation of the ability of IL-1 beta to up-regulate sPLA2 and cPLA2 gene expression as well as medium PLA2 activity. pimagedine 15-29 interleukin 1 beta Rattus norvegicus 118-127 9067439-5 1997 The activity of iNOS was selectively inhibited by application of aminoguanidine for 48 h. Our results suggest that all major CNS cells implied in cerebral blood flow regulation and neurovascular coupling are capable of rapidly producing the vasodilator NO upon intracellular increases of the universal second messenger calcium. pimagedine 65-79 nitric oxide synthase 2 Homo sapiens 16-20 9015390-8 1997 Analysis by sucrose density gradient centrifugation of the cytochrome c reductase and citrulline-forming activities in extracts of cells recovered from aminoguanidine treatment revealed that recovery was accompanied by a diminished population of iNOS monomers with an increased population of iNOS dimers. pimagedine 152-166 nitric oxide synthase 2, inducible Mus musculus 246-250 9015390-8 1997 Analysis by sucrose density gradient centrifugation of the cytochrome c reductase and citrulline-forming activities in extracts of cells recovered from aminoguanidine treatment revealed that recovery was accompanied by a diminished population of iNOS monomers with an increased population of iNOS dimers. pimagedine 152-166 nitric oxide synthase 2, inducible Mus musculus 292-296 9031736-30 1997 Aminoguanidine (at the highest concentrations) inhibited the formation of COX-1 metabolites, without affecting COX-2 activity. pimagedine 0-14 cytochrome c oxidase I, mitochondrial Mus musculus 74-79 8978317-7 1997 Aminoguanidine, a selective inhibitor of iNOS, significantly decreased the iNOS activity (1.04 +/- 0.37 compared with 29.1 +/- 8.62 pmol.min-1.mg protein-1 in untreated myosin-immunized rats, P < .01) and effectively attenuated histopathological changes of EAM on day 21. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 41-45 8978317-7 1997 Aminoguanidine, a selective inhibitor of iNOS, significantly decreased the iNOS activity (1.04 +/- 0.37 compared with 29.1 +/- 8.62 pmol.min-1.mg protein-1 in untreated myosin-immunized rats, P < .01) and effectively attenuated histopathological changes of EAM on day 21. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 75-79 9078276-12 1997 In the present study we also demonstrated that aminoguanidine (AMG), which is frequently used in cellular systems to inhibit any action of serum polyamine oxidase, apparently inhibits AdoMetDC by an irreversible mechanism that markedly stabilizes the enzyme against proteolytic degradation. pimagedine 47-61 S-adenosylmethionine decarboxylase 1 Mus musculus 184-192 9078276-12 1997 In the present study we also demonstrated that aminoguanidine (AMG), which is frequently used in cellular systems to inhibit any action of serum polyamine oxidase, apparently inhibits AdoMetDC by an irreversible mechanism that markedly stabilizes the enzyme against proteolytic degradation. pimagedine 63-66 S-adenosylmethionine decarboxylase 1 Mus musculus 184-192 8977420-9 1997 Treatment with aminoguanidine, an inhibitor of inducible nitric oxide synthase, led to augmentation of the ability of IL-1 beta to up-regulate sPLA2 and cPLA2 gene expression as well as medium PLA2 activity. pimagedine 15-29 phospholipase A2 group IIA Rattus norvegicus 143-148 8977420-9 1997 Treatment with aminoguanidine, an inhibitor of inducible nitric oxide synthase, led to augmentation of the ability of IL-1 beta to up-regulate sPLA2 and cPLA2 gene expression as well as medium PLA2 activity. pimagedine 15-29 phospholipase A2 group IVA Rattus norvegicus 153-158 8977420-9 1997 Treatment with aminoguanidine, an inhibitor of inducible nitric oxide synthase, led to augmentation of the ability of IL-1 beta to up-regulate sPLA2 and cPLA2 gene expression as well as medium PLA2 activity. pimagedine 15-29 phospholipase A2 group IB Rattus norvegicus 144-148 9402247-3 1997 The three NOS inhibitors tested (NG-nitro-L-arginine methyl ester, NG-monomethyl-L-arginine and aminoguanidine) prevented the hCG-induced PGE accumulation in cultured OCC. pimagedine 96-110 hypertrichosis 2 (generalised, congenital) Homo sapiens 126-129 9284085-4 1997 Pre-incubation with cycloheximide or aminoguanidine blocked IGF-1-stimulated NO release. pimagedine 37-51 insulin like growth factor 1 Homo sapiens 60-65 8874192-0 1996 Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase. pimagedine 86-100 nitric oxide synthase 2, inducible Mus musculus 127-158 8968377-6 1996 Contraction of the aorta in lipopolysaccharide-treated rats was restored to normal by 0.3 mM aminoguanidine (an inhibitor of inducible NO-synthase). pimagedine 93-107 nitric oxide synthase 2 Rattus norvegicus 125-146 8937711-7 1996 NG-monomethyl-L-arginine (L-NMMA), N6-iminoethyl-L-lysine (L-NIL) and aminoguanidine were much weaker inhibitors of murine NOS II than 2-amino-4-methylpyridine but, unlike 2-amino-4-methylpyridine, retained similar activity on human recombinant NOS II. pimagedine 70-84 nitric oxide synthase 2, inducible Mus musculus 123-129 8937711-7 1996 NG-monomethyl-L-arginine (L-NMMA), N6-iminoethyl-L-lysine (L-NIL) and aminoguanidine were much weaker inhibitors of murine NOS II than 2-amino-4-methylpyridine but, unlike 2-amino-4-methylpyridine, retained similar activity on human recombinant NOS II. pimagedine 70-84 nitric oxide synthase 2, inducible Mus musculus 245-251 8968550-19 1996 Treatment of rats with aminoguanidine (5 mg kg-1 + 10 mg kg-1 h-1) starting at 120 min after LTA + PepG attenuated most of the adverse effects and gave a significant inhibition of iNOS activity (in various organs) as well as an inhibition of the increase in total plasma nitrite. pimagedine 23-37 nitric oxide synthase 2 Rattus norvegicus 180-184 8982100-0 1996 Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine. pimagedine 112-126 nitric oxide synthase 2, inducible Mus musculus 70-101 8937711-25 1996 These data indicate that 2-amino-4-methylpyridine is a potent inhibitor of NOS II activity in vitro and in vivo with a similar degree of isozyme selectivity to that of L-NIL and aminoguanidine in rodents. pimagedine 178-192 nitric oxide synthase 2, inducible Mus musculus 75-81 8812641-0 1996 The Use of Aminoguanidine, a Selective iNOS Inhibitor, to Evaluate the Role of Nitric Oxide in the Development of Autoimmune Diabetes Insulin-dependent diabetes mellitus is an autoimmune disease characterized by the selective destruction of insulin-secreting beta cells found in islets of Langerhans. pimagedine 11-25 nitric oxide synthase 2 Rattus norvegicus 39-43 8863222-7 1996 Selective iNOS inhibition with either S-methyl isothiourea (SMT; 5 mg/kg IP) or aminoguanidine (AG; 20 mg/kg IP), administered 2 hours after LPS injection, significantly prevented the increase in PI associated with LPS injection. pimagedine 80-94 nitric oxide synthase 2 Rattus norvegicus 10-14 8912017-2 1996 Putrescine concentration was increased severalfold and the difference between portal and arterial blood abolished in animals pretreated with the specific diamine oxidase inhibitor aminoguanidine. pimagedine 180-194 amine oxidase, copper containing 1 Rattus norvegicus 154-169 8798439-6 1996 Aminoguanidine and iodonium diphenyl, mechanistically unrelated NOS inhibitors, also prevent the release of IL-1 activity from RAW 264.7 cells. pimagedine 0-14 interleukin 1 complex Mus musculus 108-112 8812641-14 1996 Aminoguanidine has been identified as one of the first iNOS selective inhibitors. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 55-59 8812641-15 1996 Aminoguanidine is over 50-fold more effective at inhibiting the enzymatic activity of iNOS than endothelial or neuronal NOS. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 86-90 8711805-12 1996 Treatment with the iNOS inhibitor aminoguanidine (n = 5; 100 mg/kg IP, BID for 4 days), starting 6 hours after ischemia, reduced infarct size in neocortex by 36 +/- 7% in comparison with vehicle-treated controls (n = 5) (P < .05). pimagedine 34-48 nitric oxide synthase 2 Rattus norvegicus 19-23 8760128-9 1996 Aminoguanidine, a specific inhibitor of iNOS, has no effect on cell ATP content or on .NO production. pimagedine 0-14 nitric oxide synthase 2 Homo sapiens 40-44 8711805-16 1996 The finding that aminoguanidine reduces infarct size adds further support to the hypothesis that postischemic iNOS expression contributes to ischemic brain damage. pimagedine 17-31 nitric oxide synthase 2 Rattus norvegicus 110-114 8687486-1 1996 Aminoguanidine (AG; < or =0.5 mM) is a potent inhibitor of the inducible form of nitric oxide synthase (iNOS) and, at higher concentrations, is also able to prevent advanced glycosylation of proteins. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 107-111 8687449-4 1996 Both cell death and nitric oxide production were significantly inhibited by the addition of aminoguanidine, a specific inhibitor of inducible nitric oxide synthase (iNOS), to the culture medium. pimagedine 92-106 nitric oxide synthase 2, inducible Mus musculus 132-163 8620596-7 1996 iNOS inhibition with aminoguanidine prevented or attenuated allograft heart and systemic vascular barrier dysfunction and reduced allograft serum nitrite/nitrate levels to isograft values. pimagedine 21-35 nitric oxide synthase 2 Rattus norvegicus 0-4 8687449-4 1996 Both cell death and nitric oxide production were significantly inhibited by the addition of aminoguanidine, a specific inhibitor of inducible nitric oxide synthase (iNOS), to the culture medium. pimagedine 92-106 nitric oxide synthase 2, inducible Mus musculus 165-169 8613229-3 1996 When myocytes were treated with interleukin-1beta (5 ng/mL), nitrite levels increased, and this effect was inhibited 80% by the specific iNOS inhibitor aminoguanidine. pimagedine 152-166 interleukin 1 beta Mus musculus 32-49 8761678-6 1996 This putative basolateral excreting mechanism is inhibited in the presence of the diamine oxidase inhibitor, aminoguanidine. pimagedine 109-123 amine oxidase copper containing 1 Homo sapiens 82-97 8613229-3 1996 When myocytes were treated with interleukin-1beta (5 ng/mL), nitrite levels increased, and this effect was inhibited 80% by the specific iNOS inhibitor aminoguanidine. pimagedine 152-166 nitric oxide synthase 2, inducible Mus musculus 137-141 9058007-8 1996 However, the selective inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine (AG, 100 microM) exhibited no neuroprotective effects and no reduction in the nitrite production. pimagedine 72-86 nitric oxide synthase 2 Rattus norvegicus 56-60 8829773-0 1996 Effect of aminoguanidine on in vivo expression of cytokines and inducible nitric oxide synthase in the lungs of endotoxemic rats. pimagedine 10-24 nitric oxide synthase 2 Rattus norvegicus 64-95 8829773-3 1996 We investigated in vivo expression of these cytokines and iNOS in the lungs of rats that were injected with saline, endotoxin or endotoxin plus aminoguanidine (AG), an inhibitor of iNOS. pimagedine 144-158 nitric oxide synthase 2 Rattus norvegicus 181-185 8619882-6 1996 Certain non-amino acid-based small molecules, such as aminoguanidine and certain S-alkylated isothioureas, also express selectivity towards iNOS and have anti-inflammatory and anti-shock properties. pimagedine 54-68 nitric oxide synthase 2 Homo sapiens 140-144 8666058-4 1996 Concurrent administration of aminoguanidine (a putative inducible NO synthase inhibitor) (10 mg/kg, i.v.) pimagedine 29-43 nitric oxide synthase 2, inducible Mus musculus 56-77 8571430-1 1996 BACKGROUND AND PURPOSE: We studied whether the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine reduces focal cerebral ischemic damage in a relatively noninvasive stroke model in which the rat middle cerebral artery (MCA) is occluded using an intravascular filament. pimagedine 96-110 nitric oxide synthase 2 Rattus norvegicus 47-78 8571430-1 1996 BACKGROUND AND PURPOSE: We studied whether the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine reduces focal cerebral ischemic damage in a relatively noninvasive stroke model in which the rat middle cerebral artery (MCA) is occluded using an intravascular filament. pimagedine 96-110 nitric oxide synthase 2 Rattus norvegicus 80-84 8963690-9 1996 L-NNA and amino-guanidine blocked TNF alpha-induced vasodilation. pimagedine 10-25 tumor necrosis factor Sus scrofa 34-43 8963690-11 1996 Aminoguanidine blocked TNF alpha-induced increased cGMP and attenuated the increase in cAMP. pimagedine 0-14 tumor necrosis factor Sus scrofa 23-32 8648931-8 1996 3-DG showed more intense and faster reactivity with beta 2m to form AGE and dimer as compared with glucose, and aminoguanidine suppressed the AGE and dimer formation of beta 2m by 3-DG. pimagedine 112-126 beta-2-microglobulin Homo sapiens 169-176 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. pimagedine 283-297 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. pimagedine 283-297 interleukin 1 beta Rattus norvegicus 115-133 8609118-5 1996 The production of nitrite was time-dependent and endotoxin, interleukin-1 beta, and tumor necrosis factor-alpha dose-dependent and was inhibited by the nitric-oxide-synthase inhibitors N omega-nitro-L-arginine methyl ester and aminoguanidine. pimagedine 227-241 interleukin 1 beta Bos taurus 60-111 8902526-4 1996 Studies on glycated bovine serum albumin show that aminoguanidine can affect a number of parameters associated with the nonenzymatic glycation of protein. pimagedine 51-65 albumin Homo sapiens 27-40 8639971-2 1996 Prompted by the reports that aminoguanidine also inhibits aldose reductase (AR), we have investigated the effect of aminoguanidine, 1,3-diaminoguanidine, and methylguanidine on AR activity in vitro, and in vivo. pimagedine 29-43 aldo-keto reductase family 1 member B1 Rattus norvegicus 58-74 8847314-9 1996 We conclude that aminoguanidine is a selective concentration-dependent inhibitor of the inducible form of NO synthase and may be a useful probe to evaluate the role of inducible NO synthase in the abnormal vascular contractility characteristic of endotoxemia and sepsis. pimagedine 17-31 nitric oxide synthase 2 Rattus norvegicus 168-189 8639971-1 1996 Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. pimagedine 0-14 amine oxidase, copper containing 1 Rattus norvegicus 77-92 8738527-3 1996 To elucidate whether inhibition of the IL-2-induced NOS could boost efficacy of IL-2-stimulated CTLs in vivo, we assessed lung metastases in mice injected with IL-2, the NOS inhibitor aminoguanidine (AG), their combination and the diluent. pimagedine 184-198 interleukin 2 Mus musculus 39-43 8639971-2 1996 Prompted by the reports that aminoguanidine also inhibits aldose reductase (AR), we have investigated the effect of aminoguanidine, 1,3-diaminoguanidine, and methylguanidine on AR activity in vitro, and in vivo. pimagedine 29-43 aldo-keto reductase family 1 member B1 Rattus norvegicus 76-78 8639971-1 1996 Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. pimagedine 0-14 catalase Rattus norvegicus 170-178 7489998-7 1995 Moreover, aminoguanidine (AG), a preferential inhibitor of iNOS, did not affect phenylephrine contraction of rings with or without endothelium from cirrhotic rats but reversed the blunted response in endotoxin-treated rats. pimagedine 10-24 nitric oxide synthase 2 Rattus norvegicus 59-63 8750736-4 1995 After stimulation by interferon-gamma the IC50 of L-N6-(1-iminoethyl)-lysine was 0.4 +/- 0.1 mu M and 10- or 30-fold lower than that of NG-monomethyl-L-arginine or aminoguanidine, respectively. pimagedine 164-178 interferon gamma Mus musculus 21-37 8845011-2 1996 Here we report the effects of a new class of aminoguanidine 5-HT2 antagonists, with relative selectivity for 5-HT2A receptors which are potent inhibitors of 5-HT-induced paw edema in the rat. pimagedine 45-59 5-hydroxytryptamine receptor 2A Homo sapiens 109-115 8541225-8 1995 An NO synthase inhibitor, L-NG-monomethy-L-arginine (0.5 mM) or aminoguanidine (0.5 mM) abolished increases in NO production induced by combinations of IFN-gamma and TNF-alpha, and IFN-gamma, TNF-alpha and IL-1 beta completely without effects on number of viable cells. pimagedine 64-78 interferon gamma Mus musculus 152-161 8543749-6 1995 In contrast to SKF 91488, intravenously injected aminoguanidine, a specific inhibitor of diamine oxidase (16 mg/kg intravenously), did not alter the leakage of dye induced by histamine (from 0.001 microgram/kg to 10 micrograms/kg intravenously) (p < 0.20). pimagedine 49-63 amiloride-sensitive amine oxidase [copper-containing] Cavia porcellus 89-104 7594544-7 1995 Treatment with the iNOS inhibitor, aminoguanidine, reduced NO3- levels in serum of C57BL/6 mice and eliminated resistance of these hosts to P. chabaudi AS malaria without affecting parasitemia. pimagedine 35-49 nitric oxide synthase 2, inducible Mus musculus 19-23 7594544-7 1995 Treatment with the iNOS inhibitor, aminoguanidine, reduced NO3- levels in serum of C57BL/6 mice and eliminated resistance of these hosts to P. chabaudi AS malaria without affecting parasitemia. pimagedine 35-49 NBL1, DAN family BMP antagonist Mus musculus 59-62 7498662-6 1995 The addition of either NG-monomethyl-L-arginine, an inhibitor of NO synthesis, or aminoguanidine, an inhibitor of inducible NO synthase, to the medium reversed the suppression of IL-2 receptor expression and LAK activity by lipopolysaccharide-stimulated Kupffer cells. pimagedine 82-96 nitric oxide synthase 2 Rattus norvegicus 114-135 7498662-6 1995 The addition of either NG-monomethyl-L-arginine, an inhibitor of NO synthesis, or aminoguanidine, an inhibitor of inducible NO synthase, to the medium reversed the suppression of IL-2 receptor expression and LAK activity by lipopolysaccharide-stimulated Kupffer cells. pimagedine 82-96 interleukin 2 Rattus norvegicus 179-183 8541225-8 1995 An NO synthase inhibitor, L-NG-monomethy-L-arginine (0.5 mM) or aminoguanidine (0.5 mM) abolished increases in NO production induced by combinations of IFN-gamma and TNF-alpha, and IFN-gamma, TNF-alpha and IL-1 beta completely without effects on number of viable cells. pimagedine 64-78 tumor necrosis factor Mus musculus 166-175 8541225-8 1995 An NO synthase inhibitor, L-NG-monomethy-L-arginine (0.5 mM) or aminoguanidine (0.5 mM) abolished increases in NO production induced by combinations of IFN-gamma and TNF-alpha, and IFN-gamma, TNF-alpha and IL-1 beta completely without effects on number of viable cells. pimagedine 64-78 interferon gamma Mus musculus 181-190 8541225-8 1995 An NO synthase inhibitor, L-NG-monomethy-L-arginine (0.5 mM) or aminoguanidine (0.5 mM) abolished increases in NO production induced by combinations of IFN-gamma and TNF-alpha, and IFN-gamma, TNF-alpha and IL-1 beta completely without effects on number of viable cells. pimagedine 64-78 tumor necrosis factor Mus musculus 192-201 8541225-8 1995 An NO synthase inhibitor, L-NG-monomethy-L-arginine (0.5 mM) or aminoguanidine (0.5 mM) abolished increases in NO production induced by combinations of IFN-gamma and TNF-alpha, and IFN-gamma, TNF-alpha and IL-1 beta completely without effects on number of viable cells. pimagedine 64-78 interleukin 1 beta Mus musculus 206-215 7557128-4 1995 iNOS gene expression was assessed by reverse-transcriptase polymerase chain reaction and Western blotting, immunohistochemistry was determined by its localization, and activity was inhibited with the specific inhibitor aminoguanidine administered via the drinking water for 7 days. pimagedine 219-233 nitric oxide synthase, inducible Cavia porcellus 0-4 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). pimagedine 21-35 interleukin 1 beta Rattus norvegicus 143-161 8543374-4 1995 This release was significantly inhibited by infusion with the inducible NO synthase antagonist, aminoguanidine (AG). pimagedine 96-110 nitric oxide synthase 2, inducible Mus musculus 62-83 7561687-14 1995 Aminoguanidine, a selective inhibitor of the iNOS, inhibited the in vitro production of nitric oxide by cells isolated from individual implantation sites, and more strikingly, significantly reduced early embryo losses in CBA/J females mated by DBA/2 males when given orally or parenterally to the gravid females starting on day 6 of gestation. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 45-49 8699639-1 1995 Agmatine was about as potent as aminoguanidine to inhibit the activity of the inducible form of nitric oxide synthase (iNOS) in isolated rat aorta. pimagedine 32-46 nitric oxide synthase 2 Rattus norvegicus 119-123 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). pimagedine 21-35 interleukin 1 beta Rattus norvegicus 163-172 7540573-6 1995 Recombinant rat islet iNOS was transiently and stably expressed in human kidney 293 fibroblasts, and the high enzymatic activity was inhibited by addition of the L-arginine analogs, N omega-nitro-L-arginine methyl ester and aminoguanidine. pimagedine 224-238 nitric oxide synthase 2 Rattus norvegicus 22-26 7545125-2 1995 Aminoguanidine, a selective inhibitor of the inducible NO synthase, restored the pressor responses to methoxamine in arteries of endotoxin-treated rats, but was ineffective in hyporeactive portal vein-ligated vessels. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 45-66 7579055-6 1995 The functional significance of this iNOS was then examined with aminoguanidine, a preferential inhibitor of iNOS. pimagedine 64-78 nitric oxide synthase 2 Rattus norvegicus 36-40 7579055-6 1995 The functional significance of this iNOS was then examined with aminoguanidine, a preferential inhibitor of iNOS. pimagedine 64-78 nitric oxide synthase 2 Rattus norvegicus 108-112 7579055-9 1995 The reversal of LPS-induced vascular hyporesponsiveness by aminoguanidine therefore strongly supports the functional importance of iNOS mRNA expression in the aorta of endotoxemic rats. pimagedine 59-73 nitric oxide synthase 2 Rattus norvegicus 131-135 7537283-4 1995 Aminoguanidine (AG), a selective inhibitor of the cytokine-inducible NOS, enhanced MBP-induced EAE, but had no significant effects on myelin-induced EAN. pimagedine 0-14 myelin basic protein Rattus norvegicus 83-86 7541282-2 1995 We have investigated the effects of aminoguanidine, a relatively selective inhibitor of the cytokine-inducible isoform of nitric oxide synthase (iNOS), on the delayed circulatory failure, vascular hyporeactivity to vasoconstrictor agents, and iNOS activity in a rat model of circulatory shock induced by bacterial endotoxin (E. coli lipopolysaccharide; LPS). pimagedine 36-50 nitric oxide synthase 2 Rattus norvegicus 145-149 7541282-17 1995 In LPS-rats treated with aminoguanidine, iNOS activity in the lung was attenuated by 44+/- 5% (n = 6, P <0.05).Moreover, when added in vitro to lung homogenates obtained from LPS-rats, aminoguanidine and N omega-nitro-L-arginine methyl ester (L-NAME; 10-8 to 10-3 M) caused a concentration-dependent inhibition of iNOS activity (n = 3-6, IC50: 30 +/- 12 and 11 +/- 6pEM, respectively P>0.05). pimagedine 25-39 nitric oxide synthase 2 Rattus norvegicus 41-45 7541282-17 1995 In LPS-rats treated with aminoguanidine, iNOS activity in the lung was attenuated by 44+/- 5% (n = 6, P <0.05).Moreover, when added in vitro to lung homogenates obtained from LPS-rats, aminoguanidine and N omega-nitro-L-arginine methyl ester (L-NAME; 10-8 to 10-3 M) caused a concentration-dependent inhibition of iNOS activity (n = 3-6, IC50: 30 +/- 12 and 11 +/- 6pEM, respectively P>0.05). pimagedine 25-39 nitric oxide synthase 2 Rattus norvegicus 317-321 7541282-17 1995 In LPS-rats treated with aminoguanidine, iNOS activity in the lung was attenuated by 44+/- 5% (n = 6, P <0.05).Moreover, when added in vitro to lung homogenates obtained from LPS-rats, aminoguanidine and N omega-nitro-L-arginine methyl ester (L-NAME; 10-8 to 10-3 M) caused a concentration-dependent inhibition of iNOS activity (n = 3-6, IC50: 30 +/- 12 and 11 +/- 6pEM, respectively P>0.05). pimagedine 188-202 nitric oxide synthase 2 Rattus norvegicus 41-45 7541282-19 1995 In addition, the inhibitory effect of aminoguanidine on iNOS activity showed a slower onset than that of L-NAME(maximal inhibition at 90 min and 30 min, respectively).5. pimagedine 38-52 nitric oxide synthase 2 Rattus norvegicus 56-60 7541282-24 1995 at 2 h and 6 h after LPS) did not affect the survival rate(11%, n=9).6 Thus, aminoguanidine inhibits iNOS activity and attenuates the delayed circulatory failure caused by endotoxic shock in the rat and improves survival in a murine model of endotoxaemia. pimagedine 77-91 nitric oxide synthase 2 Rattus norvegicus 101-105 7541282-25 1995 Aminoguanidine,or novel, more potent selective inhibitors of iNOS may be useful in the therapy of septic shock. pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 61-65 7534998-3 1995 Both the NO synthase (NOS) antagonists NG-monomethyl-L-arginine (L-NMMA; nonselective) and aminoguanidine (selective for iNOS) enhanced PE-induced contraction in endothelium-denuded vessels from LPS-treated rats. pimagedine 91-105 nitric oxide synthase 2 Rattus norvegicus 121-125 7535933-7 1995 The iNOS inhibitor aminoguanidine markedly enhances in vitro resorption by activated NOS-rich chick osteoclasts and by normal rat osteoclasts treated with LPS or IFN-gamma. pimagedine 19-33 nitric oxide synthase 2 Gallus gallus 4-8 7535933-7 1995 The iNOS inhibitor aminoguanidine markedly enhances in vitro resorption by activated NOS-rich chick osteoclasts and by normal rat osteoclasts treated with LPS or IFN-gamma. pimagedine 19-33 interferon gamma Rattus norvegicus 162-171 7536100-0 1995 IGF-I stimulates renal function in the isolated rat kidney: inhibition by aminoguanidine and nitroarginine methyl ester. pimagedine 74-88 insulin-like growth factor 1 Rattus norvegicus 0-5 7616326-0 1995 Effects of aminoguanidine and pyridoxal phosphate on glycation reaction of aspartate aminotransferase and serum albumin. pimagedine 11-25 albumin Homo sapiens 106-119 7530927-3 1995 Twenty-four hours later rats received intraperitoneal injections of the iNOS inhibitor aminoguanidine (100 mg/kg twice per day; n = 10) or of aminoguanidine + L-arginine (300 mg/kg four times per day; n = 7), aminoguanidine + D-arginine (n = 7), arginine alone (n = 6), or vehicle (n = 9). pimagedine 87-101 nitric oxide synthase 2 Rattus norvegicus 72-76 7530927-10 1995 We conclude that aminoguanidine selectively inhibits iNOS activity in the area of infarction and reduces the volume of the infarct produced by middle cerebral artery occlusion. pimagedine 17-31 nitric oxide synthase 2 Rattus norvegicus 53-57 7609280-8 1995 Because gamma-aminobutyric acid formation was completely prevented by the diamine oxidase inhibitor aminoguanidine but was not modified after inactivation of ornithine aminotransferase by 5-fluoromethylornithine, it is evident that gamma-aminobutyric acid is formed in the mucosa from ornithine via putrescine as an intermediate. pimagedine 100-114 amine oxidase, copper containing 1 Rattus norvegicus 74-89 7536162-7 1995 By contrast, administration of aminoguanidine (12.5-50 mg/kg, s.c.) 3 h after endotoxin, at the time of the expression of the inducible NO synthase, reduced the subsequent endotoxin-induced vascular leakage, as did L-NMMA (50 mg/kg). pimagedine 31-45 nitric oxide synthase 2 Rattus norvegicus 126-147 7536162-8 1995 In homogenates of rat ileal or colonic tissue, aminoguanidine inhibited both the constitutive and inducible NO synthase activity showing only 2-fold selectivity for the inducible isoform. pimagedine 47-61 nitric oxide synthase 2 Rattus norvegicus 98-119 7986197-4 1994 The mean second order rate constant for the reaction of methylglyoxal with aminoguanidine, kMG.AG = 0.39 +/- 0.06 M-1 sec-1 at pH 7.4 and 37 degrees. pimagedine 75-89 secretory blood group 1, pseudogene Homo sapiens 118-123 7528779-5 1995 Treatment with aminoguanidine, a preferential inhibitor of the inducible nitric oxide synthase isoform, prevented the increased nitric oxide production in the transplanted organ and significantly attenuated the pathogenesis of acute rejection. pimagedine 15-29 nitric oxide synthase 2 Rattus norvegicus 63-94 8584654-2 1995 The similarity of this compound"s structure to that of the diamine oxidase (DAO) inhibitor, aminoguanidine, led us to investigate the possibility that agmatine might be a substrate for this enzyme. pimagedine 92-106 amine oxidase, copper containing 1 Rattus norvegicus 59-74 8584654-2 1995 The similarity of this compound"s structure to that of the diamine oxidase (DAO) inhibitor, aminoguanidine, led us to investigate the possibility that agmatine might be a substrate for this enzyme. pimagedine 92-106 amine oxidase, copper containing 1 Rattus norvegicus 76-79 8584654-6 1995 The metabolism of agmatine by DAO was inhibited by aminoguanidine (IC50 14.9 nM) and by the antidepressant, phenelzine (IC50 1.95 microM). pimagedine 51-65 amine oxidase, copper containing 1 Rattus norvegicus 30-33 7530059-4 1994 Preferential inhibition of the inducible form of nitric oxide synthase using two daily injections of 5 mg/rat of aminoguanidine prevented IL-1 beta-induced hyperglycaemia and hypoinsulinaemia, and slightly reduced the pyrogenicity of IL-1 on 3 out of 5 days. pimagedine 113-127 interleukin 1 beta Rattus norvegicus 138-147 8077847-10 1994 Aminoguanidine (20 mM) substantially decreased thiobarbituric acid-reactive substances (TBARS) activity and lipid peroxide formation, but only partially prevented the increase of REM (-55%), apoB fluorescence (-39%), and degradation by macrophages (-54%). pimagedine 0-14 apolipoprotein B Homo sapiens 191-195 7514189-4 1994 NG-monomethyl-L-arginine (L-NMMA), which blocks the activity of both constitutive and inducible nitric oxide synthase (cNOS and iNOS), aminoguanidine, a recently described selective iNOS inhibitor, dexamethasone, or cycloheximide abolished the release of NO2- and attenuated the exaggerated BK-induced PGE2 production. pimagedine 135-149 nitric oxide synthase, inducible Oryctolagus cuniculus 86-117 7514579-7 1994 Suppression of nitrite production by addition of the nitric oxide synthase inhibitor aminoguanidine both during the IFN-gamma treatment and during the rickettsial infection also did not inhibit the killing of the RAW264.7 cells. pimagedine 85-99 interferon gamma Mus musculus 116-125 7514114-7 1994 Addition of the NO synthase inhibitors NG-monomethyl-L-arginine and aminoguanidine inhibited production of NO2- and NO3-, but not iNOS mRNA. pimagedine 68-82 NBL1, DAN family BMP antagonist Mus musculus 116-119 7514114-7 1994 Addition of the NO synthase inhibitors NG-monomethyl-L-arginine and aminoguanidine inhibited production of NO2- and NO3-, but not iNOS mRNA. pimagedine 68-82 nitric oxide synthase 2, inducible Mus musculus 130-134 7504482-3 1993 The addition of aminoguanidine (1 mM), a preferential inhibitor of the inducible NO-synthase, completely abolished NO2-accumulation. pimagedine 16-30 nitric oxide synthase 2 Rattus norvegicus 71-92 24190739-5 1994 Aldose reductase inhibitors decrease the concentration of methylglyoxal in experimental diabetic rats to normal levels, aminoguanidine and L-arginine scavenge methylglyoxal; these effects may be involved in their prospective preventive therapy of diabetic complications. pimagedine 120-134 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 18472930-2 1994 Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histamine, causing a leftward displacement of the concentration response curves, whereas the diamine oxidase inhibitor aminoguanidine had no effect. pimagedine 262-276 histamine N-methyltransferase Homo sapiens 64-67 18472930-2 1994 Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histamine, causing a leftward displacement of the concentration response curves, whereas the diamine oxidase inhibitor aminoguanidine had no effect. pimagedine 262-276 amine oxidase copper containing 1 Homo sapiens 236-251 7504698-4 1993 We show that IL-1 beta treatment results in the formation of nitric oxide (as measured by accumulation of nitrite and cGMP) in both a time- and concentration-dependent manner that is prevented by aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase. pimagedine 196-210 interleukin 1 beta Rattus norvegicus 13-22 8149833-5 1994 Pretreatment with aminoguanidine sulfate (diamine oxidase inhibitor) at 30 mg/kg significantly increased the gastric acid secretion caused by intraduodenal histamine. pimagedine 18-40 amine oxidase, copper containing 1 Rattus norvegicus 42-57 8425439-6 1993 Administration of EGF, spermine, aminoguanidine (an inhibitor of degradation of PA), or 16,16-dmPGE2 after stress promoted significantly the healing and DNA synthesis, but pretreatment with DFMO abolished the effect of EGF but not that of spermine. pimagedine 33-47 epidermal growth factor like 1 Rattus norvegicus 219-222 8216363-0 1993 Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro. pimagedine 0-14 catalase Homo sapiens 69-77 8325182-7 1993 Pretreatment with aminoguanidine, which suppressed diamine oxidase activity, increased the mortality rate. pimagedine 18-32 amine oxidase, copper containing 1 Rattus norvegicus 51-66 7506664-5 1993 These results (1) confirm the selective inhibition of the inducible isoform of NO synthase by aminoguanidine, (2) indicate that N,N"-diaminoguanidine, while approximately 30 times less potent than aminoguanidine in inhibiting inducible NO synthase, has very little effect on constitutive NO synthase activity, and (3) 1,1-dimethylguanidine, like L-NMMA, is a relatively potent inhibitor of both isoforms of NO synthase. pimagedine 135-149 nitric oxide synthase 2 Rattus norvegicus 226-247 7691748-9 1993 Nitrite production was blocked by NGMA or aminoguanidine, and these compounds markedly relieved the synergistic inhibitory effect of IFN-gamma plus TNF-alpha on the growth of strain 83-2P in L929 cells. pimagedine 42-56 interferon gamma Mus musculus 133-142 7691748-9 1993 Nitrite production was blocked by NGMA or aminoguanidine, and these compounds markedly relieved the synergistic inhibitory effect of IFN-gamma plus TNF-alpha on the growth of strain 83-2P in L929 cells. pimagedine 42-56 tumor necrosis factor Mus musculus 148-157 8344450-6 1993 DETAPAC, aminoguanidine and 2-mercaptoethanol all partially block myofibrillar protein glycation and ATPase activity is less inactivated. pimagedine 9-23 dynein axonemal heavy chain 8 Homo sapiens 101-107 7682510-4 1993 Thus, aminoguanidine may be useful as a selective inhibitor of the inducible NO synthase in the treatment of disease states characterized by the pathological overproduction of NO. pimagedine 6-20 nitric oxide synthase 2 Homo sapiens 67-88 8461048-0 1993 Stabilization of S-adenosylmethionine decarboxylase by aminoguanidine. pimagedine 55-69 S-adenosylmethionine decarboxylase 1 Mus musculus 17-51 8461048-2 1993 However, in the present study, we demonstrate that aminoguanidine, besides affecting the degradation of polyamines, may affect one of the important regulatory enzymes in the biosynthesis of polyamines, namely S-adenosylmethionine decarboxylase (AdoMetDC). pimagedine 51-65 S-adenosylmethionine decarboxylase 1 Mus musculus 209-243 8461048-2 1993 However, in the present study, we demonstrate that aminoguanidine, besides affecting the degradation of polyamines, may affect one of the important regulatory enzymes in the biosynthesis of polyamines, namely S-adenosylmethionine decarboxylase (AdoMetDC). pimagedine 51-65 S-adenosylmethionine decarboxylase 1 Mus musculus 245-253 8461048-3 1993 Aminoguanidine was shown to induce a 2-3-fold increase in the AdoMetDC levels in L1210 cells. pimagedine 0-14 S-adenosylmethionine decarboxylase 1 Mus musculus 62-70 8461048-4 1993 This increase was fully explained by a stabilization of the enzyme, probably caused by the binding of aminoguanidine to the active site of AdoMetDC. pimagedine 102-116 S-adenosylmethionine decarboxylase 1 Mus musculus 139-147 8136460-2 1993 We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by the cytokine interleukin-1 beta. pimagedine 40-54 interleukin 1 beta Mus musculus 146-164 7692996-8 1993 Both dexamethasone, and the nitric oxide synthase inhibitors NMMA and aminoguanidine also prevent IL-1 beta induced islet degeneration. pimagedine 70-84 interleukin 1 beta Homo sapiens 98-107 8420439-4 1993 In contrast of SKF 91488, aerosolized aminoguanidine, a specific inhibitor of diamine oxidase (10(-2) M, 90 breaths), did not alter the provocation concentration of histamine (p > 0.20). pimagedine 38-52 amiloride-sensitive amine oxidase [copper-containing] Cavia porcellus 78-93 1782416-8 1991 In tests with oral administration of aminoguanidine that is known to suppress the activity of diamino-oxidase (DAO) and to inhibit the degradation of polyamines, EGF showed a markedly enhanced gastroprotective activity against ethanol damage. pimagedine 37-51 D-amino-acid oxidase Rattus norvegicus 94-109 8243835-4 1993 Diamine oxidase (DAO) activity in pancreas is very low and the potent DAO inhibitor aminoguanidine failed to alter any of the measured parameters except DAO. pimagedine 84-98 amine oxidase, copper containing 1 Rattus norvegicus 70-73 8243835-4 1993 Diamine oxidase (DAO) activity in pancreas is very low and the potent DAO inhibitor aminoguanidine failed to alter any of the measured parameters except DAO. pimagedine 84-98 amine oxidase, copper containing 1 Rattus norvegicus 70-73 1534842-1 1992 The contractile response of isolated guinea pig trachea to histamine was potentiated in the presence of the histamine N-methyltransferase (HMT) inhibitor SKF 91488, whereas the diamine oxidase inhibitor aminoguanidine was without effect. pimagedine 203-217 amiloride-sensitive amine oxidase [copper-containing] Cavia porcellus 177-192 1290060-5 1992 The effects of ornithine decarboxylase (ODC) blockade with difluoromethyl ornithine (DFMO) and of diamine oxidase (DAO) blockade with aminoguanidine, are described. pimagedine 134-148 amine oxidase, copper-containing 1 Mus musculus 98-113 1290060-5 1992 The effects of ornithine decarboxylase (ODC) blockade with difluoromethyl ornithine (DFMO) and of diamine oxidase (DAO) blockade with aminoguanidine, are described. pimagedine 134-148 amine oxidase, copper-containing 1 Mus musculus 115-118 1451951-8 1992 Aminoguanidine has been identified as both an inhibitor of the formation of advanced glycation end products, and an aldose reductase inhibitor. pimagedine 0-14 aldo-keto reductase family 1 member B1 Rattus norvegicus 116-132 1644166-6 1992 We now demonstrate that fasted rats show a high degree of [3H]GABA formation from [3H]putrescine in the oxyntic mucosa and that feeding or injections of gastrin, caerulein or the DAO-inhibitor aminoguanidine decrease such [3H]GABA formation and, instead, stimulate formation of [3H]spermidine. pimagedine 193-207 amine oxidase, copper containing 1 Rattus norvegicus 179-182 1567380-2 1992 The nematode enzyme was clearly distinguishable from monoamine and diamine oxidases as well as from the mammalian polyamine oxidase, as shown by the use of the specific inhibitors pargyline, aminoguanidine and MDL 72527 respectively. pimagedine 191-205 polyamine oxidase Homo sapiens 114-131 1727735-2 1992 Aminoguanidine inhibited glucose-derived AGE formation on RNase A by 67-85% at aminoguanidine-glucose molar ratios of 1:5 to 1:50 without affecting the concentration of Amadori products. pimagedine 0-14 ribonuclease A family member 1, pancreatic Homo sapiens 58-65 1727735-2 1992 Aminoguanidine inhibited glucose-derived AGE formation on RNase A by 67-85% at aminoguanidine-glucose molar ratios of 1:5 to 1:50 without affecting the concentration of Amadori products. pimagedine 79-93 ribonuclease A family member 1, pancreatic Homo sapiens 58-65 1681737-5 1991 A possible relationship between changes in cellular DAO activity and cell proliferation was also investigated by using aminoguanidine, a specific and potent DAO inhibitor. pimagedine 119-133 amine oxidase copper containing 1 Homo sapiens 157-160 1907249-3 1991 These compounds also inhibited rat eye lens aldose reductase activity in vitro noncompetitively with respect to NADPH with Ki = 30.6 mM for monoaminoguanidine and Ki = 12.5 mM for diaminoguanidine. pimagedine 140-158 aldo-keto reductase family 1 member B1 Rattus norvegicus 44-60 1752025-1 1991 It has been proposed that the diamine oxidase inhibitor aminoguanidine may be a potential therapeutically important anabolic agent. pimagedine 56-70 amine oxidase, copper containing 1 Rattus norvegicus 30-45 1782416-8 1991 In tests with oral administration of aminoguanidine that is known to suppress the activity of diamino-oxidase (DAO) and to inhibit the degradation of polyamines, EGF showed a markedly enhanced gastroprotective activity against ethanol damage. pimagedine 37-51 D-amino-acid oxidase Rattus norvegicus 111-114 1782416-8 1991 In tests with oral administration of aminoguanidine that is known to suppress the activity of diamino-oxidase (DAO) and to inhibit the degradation of polyamines, EGF showed a markedly enhanced gastroprotective activity against ethanol damage. pimagedine 37-51 epidermal growth factor like 1 Rattus norvegicus 162-165 2124566-0 1990 Aminoguanidine blocks intestinal diamine oxidase (DAO) activity and enhances the intestinal adaptive response to resection in the rat. pimagedine 0-14 amine oxidase, copper containing 1 Rattus norvegicus 33-48 1814681-0 1991 Inhibition of diamine oxidase from porcine kidney by pentamidine and other aminoguanidine compounds. pimagedine 75-89 amine oxidase copper containing 1 Homo sapiens 14-29 2327969-2 1990 This was performed by treating rats with aminoguanidine [an inhibitor of Cu-dependent amine oxidase (CuAO)], NN"-bis(buta-2,3-dienyl)butane-1,4-diamine [MDL 72527, an inhibitor of FAD-dependent polyamine oxidase (PAO)], tetrachloromethane (hepatotoxic agent) and combinations of these compounds. pimagedine 41-55 polyamine oxidase Rattus norvegicus 194-211 2327969-2 1990 This was performed by treating rats with aminoguanidine [an inhibitor of Cu-dependent amine oxidase (CuAO)], NN"-bis(buta-2,3-dienyl)butane-1,4-diamine [MDL 72527, an inhibitor of FAD-dependent polyamine oxidase (PAO)], tetrachloromethane (hepatotoxic agent) and combinations of these compounds. pimagedine 41-55 polyamine oxidase Rattus norvegicus 213-216 1902109-0 1991 Monoaminoguanidine inhibits aldose reductase. pimagedine 0-18 aldo-keto reductase family 1 member B Homo sapiens 28-44 2158249-2 1990 The assay system was used to study a possible inhibitory effect by aminoguanidine on CNPase specific activity. pimagedine 67-81 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 85-91 2124566-0 1990 Aminoguanidine blocks intestinal diamine oxidase (DAO) activity and enhances the intestinal adaptive response to resection in the rat. pimagedine 0-14 amine oxidase, copper containing 1 Rattus norvegicus 50-53 2124566-2 1990 Aminoguanidine (AG), a DAO inhibitor, was administered subcutaneously (25 mg kg-1 day-1) to rats for 11 days after small bowel transection (n = 6) or resection (n = 6). pimagedine 0-14 amine oxidase, copper containing 1 Rattus norvegicus 23-26 34446210-4 2021 MB + PQ-induced changes in nitrite content, lipid peroxidation (LPO), iNOS expression/activity and inflammatory mediators were alleviated by aminoguanidine (AG), an iNOS inhibitor, without any change in CYP2E1. pimagedine 141-155 nitric oxide synthase 2 Rattus norvegicus 70-74 2128501-4 1990 In the first trials authentic histamine in quantities similar to that in normal amounts of food or cheese bought from a supermarket produced life-threatening reactions if the DAO was inhibited by pretreatment with aminoguanidine. pimagedine 214-228 amine oxidase copper containing 1 Homo sapiens 175-178 15879682-2 2005 Aminoguanidine, an iNOS inhibitor, was evaluated at the same time as a reference (positive control). pimagedine 0-14 nitric oxide synthase 2 Rattus norvegicus 19-23 15879682-8 2005 Shengmai San shared with the aminoguanidine almost the same efficacy in reducing iNOS-dependent NO and cytokines overproduction during heat stroke. pimagedine 29-43 nitric oxide synthase 2 Rattus norvegicus 81-85 15879682-9 2005 These results suggest that Shengmai San or aminoguanidine protects against heat stroke-induced arterial hypotension and cerebral ischemia by inhibition of iNOS-dependent NO overproduction in the brain and excessive accumulation of several inflammatory cytokines in the peripheral blood stream. pimagedine 43-57 nitric oxide synthase 2 Rattus norvegicus 155-159 34446210-4 2021 MB + PQ-induced changes in nitrite content, lipid peroxidation (LPO), iNOS expression/activity and inflammatory mediators were alleviated by aminoguanidine (AG), an iNOS inhibitor, without any change in CYP2E1. pimagedine 141-155 nitric oxide synthase 2 Rattus norvegicus 165-169 34703363-5 2021 Aminoguanidine, the reference drug inhibited caspase-3/7 activity by 56.2% and 54.7% through attenuation of dichlorofluorescin and methylglyoxal, respectively. pimagedine 0-14 caspase 3 Homo sapiens 45-56 34584641-3 2021 This study sought to assess the local effect of different concentrations of aminoguanidine hydrochloride (AG), a selective iNOS inhibitor, on bone healing in rats. pimagedine 76-104 nitric oxide synthase 2 Rattus norvegicus 123-127 34579637-13 2022 Its anti-inflammatory behaviour was similar to that of aminoguanidine, which is a selective iNOS inhibitor. pimagedine 55-69 nitric oxide synthase 2 Rattus norvegicus 92-96 34153226-6 2021 In streptozotocin-induced diabetic mice, the average islet area and islet immunoreactivities for insulin and CD31 were decreased and the islet immunoreactivities for AGEs and alpha-SMA and fibrosis were increased, which were prevented by the AGE inhibitor aminoguanidine. pimagedine 256-270 platelet/endothelial cell adhesion molecule 1 Mus musculus 109-113 34153226-6 2021 In streptozotocin-induced diabetic mice, the average islet area and islet immunoreactivities for insulin and CD31 were decreased and the islet immunoreactivities for AGEs and alpha-SMA and fibrosis were increased, which were prevented by the AGE inhibitor aminoguanidine. pimagedine 256-270 actin alpha 2, smooth muscle, aorta Mus musculus 175-184 34153226-7 2021 Immunofluorescence double staining showed that alpha-SMA-positive staining co-localized with CD31-positive staining in the diabetic islets, which was effectively prevented by aminoguanidine. pimagedine 175-189 actin alpha 2, smooth muscle, aorta Mus musculus 47-56 34153226-7 2021 Immunofluorescence double staining showed that alpha-SMA-positive staining co-localized with CD31-positive staining in the diabetic islets, which was effectively prevented by aminoguanidine. pimagedine 175-189 platelet/endothelial cell adhesion molecule 1 Mus musculus 93-97 34381316-8 2021 In vitro, (18F)FBAT rapidly and progressively accumulated in murine microglial BV2 cells exposed to LPS; however, (18F)FBAT accumulation was inhibited by aminoguanidine, a selective iNOS inhibitor. pimagedine 154-168 nitric oxide synthase 2, inducible Mus musculus 182-186 34381316-14 2021 Aminoguanidine, selective iNOS inhibitor, pretreatment significantly reduced the AUC0-30min and V t values in LPS-induced mice. pimagedine 0-14 nitric oxide synthase 2, inducible Mus musculus 26-30 34365446-1 2021 The aim of the research is to study the effect of L-arginine, the precursor of nitric oxide, and aminoguanidine, the inhibitor of inducible nitric oxide synthase, on morpho-functional changes in the liver of BALB/c mice with antiphospholipid syndrome. pimagedine 97-111 nitric oxide synthase 2, inducible Mus musculus 130-161 34365446-8 2021 The maximum effect on the morphological state of the liver was observed in using a combination of L-arginine and aminoguanidine. pimagedine 113-127 secreted acidic cysteine rich glycoprotein Mus musculus 19-21 34365446-9 2021 The protective effect of L-arginine and aminoguanidine on the microcirculation has been proved that evidences liver function restoration in mice with antiphospholipid syndrome. pimagedine 40-54 secreted acidic cysteine rich glycoprotein Mus musculus 55-57 35594713-6 2022 We further demonstrated that advanced glycation end products (AGEs) treatment also promoted the expression of Gli1 and ppargamma in organotypic cultured mouse MG. AGEs inhibitor Aminoguanidine suppressed high glucose caused Gli1 upregulation in organotypic cultured mouse MG. pimagedine 178-192 GLI-Kruppel family member GLI1 Mus musculus 110-114 35594713-6 2022 We further demonstrated that advanced glycation end products (AGEs) treatment also promoted the expression of Gli1 and ppargamma in organotypic cultured mouse MG. AGEs inhibitor Aminoguanidine suppressed high glucose caused Gli1 upregulation in organotypic cultured mouse MG. pimagedine 178-192 peroxisome proliferator activated receptor gamma Mus musculus 119-128 35594713-6 2022 We further demonstrated that advanced glycation end products (AGEs) treatment also promoted the expression of Gli1 and ppargamma in organotypic cultured mouse MG. AGEs inhibitor Aminoguanidine suppressed high glucose caused Gli1 upregulation in organotypic cultured mouse MG. pimagedine 178-192 GLI-Kruppel family member GLI1 Mus musculus 224-228