PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23600675-1	2014	KPC-2 beta-lactamase demonstrates a wide substrate spectrum that includes carbapenamases, oxyimino-cephalosporins, and cephamycins.	Cephamycins	119-130	KPC-2 beta-lactamase	Escherichia coli	0-20
15743578-1	2005	INTRODUCTION: In the last years, we have verified the increasing emergence of bacteria, specially Escherichia coli, that produce expanded spectrum beta-lactamases (ESBL), enzymes which confer resistance to all cephalosporins (except cephamycins) and aztreonam.	Cephamycins	233-244	EsbL	Escherichia coli	164-168
21746945-1	2011	Increasing resistance to quinolones, aminoglycosides, and/or cephamycins in extended-spectrum-beta-lactamase (ESBL)-producing Enterobacteriaceae exacerbates the already limited antibiotic treatment options for infections due to these microbes.	Cephamycins	61-72	beta-lactamase	Klebsiella pneumoniae	94-108
18772158-8	2008	Although the isolate did not produce an AmpC-type enzyme, the production of KPC-2 was associated with positive boronic acid disc tests using cephamycins and cefotaxime as well as cefepime and carbapenems as substrates.	Cephamycins	141-152	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	76-81
18051801-7	2007	ESBL-producing E. coli were sensitive to the following antibiotics: carbapenem; cephamycin; aminoglycoside; and synthesized penicillin.	Cephamycins	80-90	EsbL	Escherichia coli	0-4
17576696-10	2007	Conjugational transfer of the plasmid-mediated blaDHA-1 gene into Lkp11 resulted in a significant increase in the MICs of cephamycins and beta-lactamase inhibitors, but not in those of carbapenems.	Cephamycins	122-133	ampC beta-lactamase	Klebsiella pneumoniae	47-55
16440125-7	2006	Flomoxef and cefmetazole were the most active cephamycins (88.8% and 90.0% ESBL-EC and 93.1% and 87.1% ESBL-KP susceptible, respectively), followed by ceftibuten (85.0% and 80.2%) and cefoxitin (42.5% and 49.5%).	Cephamycins	46-57	EsbL	Escherichia coli	75-79
16440125-7	2006	Flomoxef and cefmetazole were the most active cephamycins (88.8% and 90.0% ESBL-EC and 93.1% and 87.1% ESBL-KP susceptible, respectively), followed by ceftibuten (85.0% and 80.2%) and cefoxitin (42.5% and 49.5%).	Cephamycins	46-57	EsbL	Escherichia coli	103-107
16701983-10	2006	The mechanisms of resistance of 44 of the 46 isolates to cephalosporins and cephamycins were ESBL production and/or plasmid-encoded AmpC beta-lactamase and/or IMP-1 beta-lactamase production.	Cephamycins	76-87	beta-lactamase	Klebsiella pneumoniae	137-151
16701983-10	2006	The mechanisms of resistance of 44 of the 46 isolates to cephalosporins and cephamycins were ESBL production and/or plasmid-encoded AmpC beta-lactamase and/or IMP-1 beta-lactamase production.	Cephamycins	76-87	beta-lactamase	Klebsiella pneumoniae	165-179
11376058-7	2001	Thus, it is clinically important to detect ESBL production by klebsiellae or E. coli even when cephalosporin MICs are in the susceptible range (<or = 8 microg/ml) and to report ESBL-producing organisms as resistant to aztreonam and all cephalosporins (with the exception of cephamycins).	Cephamycins	277-288	EsbL	Escherichia coli	43-47
15273099-9	2004	The bla(GES-4) gene found in strain KG502 might well emerge from a point mutation in the bla(GES-3) gene harbored by its ancestor strains, such as strain KG525, under heavy antibiotic stress in order to acquire extended properties of resistance to cephamycins and carbapenems.	Cephamycins	248-259	TEM beta-lactamase	Klebsiella pneumoniae	4-7
15273099-9	2004	The bla(GES-4) gene found in strain KG502 might well emerge from a point mutation in the bla(GES-3) gene harbored by its ancestor strains, such as strain KG525, under heavy antibiotic stress in order to acquire extended properties of resistance to cephamycins and carbapenems.	Cephamycins	248-259	TEM beta-lactamase	Klebsiella pneumoniae	89-92
12812716-6	2003	Because these strains had high MICs of > or = 16 microg/ml for cephamycins such as cefoxitin and cefmetazole, these strains might produce high levels of AmpC in addition to ESBL.	Cephamycins	66-77	beta-lactamase	Escherichia coli	156-160
12812716-6	2003	Because these strains had high MICs of > or = 16 microg/ml for cephamycins such as cefoxitin and cefmetazole, these strains might produce high levels of AmpC in addition to ESBL.	Cephamycins	66-77	EsbL	Escherichia coli	176-180
11687315-10	2001	The majority of cephamycin resistant E. coli strains in Toronto have attenuator and/or promotor mutations upstream of the chromosomal ampC gene.	Cephamycins	16-26	beta-lactamase	Escherichia coli	134-138
10103197-3	1999	The IMP-1 metallo-beta-lactamase exhibits a broad-spectrum activity profile that includes activity against penicillins, cephalosporins, cephamycins, oxacephamycins, and carbapenems.	Cephamycins	136-147	Beta lactamase	Pseudomonas aeruginosa	18-32
10722487-6	2000	Purified VIM-2 beta-lactamase had a pI of 5.6, a relative molecular mass of 29.7 kDa, and a broad substrate hydrolysis range, including penicillins, cephalosporins, cephamycins, oxacephamycins, and carbapenems, but not monobactams.	Cephamycins	165-176	VIM-2	Pseudomonas aeruginosa	9-14
9756914-7	1998	The comparison of the NMC-A structure with those of other class A enzymes and enzyme-ligand complexes, indicated that the position of Asn-132 in NMC-A provides critical additional space in the region of the protein where the poorer substrates for class A beta-lactamases, such as cephamycins and carbapenems, need to be accommodated.	Cephamycins	280-291	amyloid beta precursor protein	Homo sapiens	253-259
9710678-4	1998	The plasmid-mediated cephalosporinases (MIR-1, FOX-1, MOX-1, BIL-1, CMY-1, CMY-2, and LAT-1) hydrolyze extended-spectrum cephalosporins and cephamycins and are not inhibited by clavulanic acid.	Cephamycins	140-151	fibronectin type III and SPRY domain containing 1 like	Homo sapiens	40-45
9710678-4	1998	The plasmid-mediated cephalosporinases (MIR-1, FOX-1, MOX-1, BIL-1, CMY-1, CMY-2, and LAT-1) hydrolyze extended-spectrum cephalosporins and cephamycins and are not inhibited by clavulanic acid.	Cephamycins	140-151	RNA binding fox-1 homolog 1	Homo sapiens	47-52
9710678-4	1998	The plasmid-mediated cephalosporinases (MIR-1, FOX-1, MOX-1, BIL-1, CMY-1, CMY-2, and LAT-1) hydrolyze extended-spectrum cephalosporins and cephamycins and are not inhibited by clavulanic acid.	Cephamycins	140-151	mesenchyme homeobox 1	Homo sapiens	54-59
9710678-4	1998	The plasmid-mediated cephalosporinases (MIR-1, FOX-1, MOX-1, BIL-1, CMY-1, CMY-2, and LAT-1) hydrolyze extended-spectrum cephalosporins and cephamycins and are not inhibited by clavulanic acid.	Cephamycins	140-151	solute carrier family 7 member 5	Homo sapiens	86-91
7811034-1	1994	Klebsiella pneumoniae BA32, a clinical isolate from Buenos Aires, Argentina, was found to produce a plasmid-encoded beta-lactamase (FOX-1) which conferred resistance to broad-spectrum cephalosporins and cephamycins.	Cephamycins	203-214	beta-lactamase	Klebsiella pneumoniae	116-130
2232271-4	1990	High-level MRSA contained a larger amount of PBP 2" than moderate-level MRSA, and the amount of PBP 2" decreased by increasing the temperature of the culture; the extent of decrease was larger in a strain which was sensitive at 37 degrees C than a strain which exerted relatively high level resistance even at 40 degrees C. A cephamycin-resistant, methicillin-sensitive strain began to synthesize PBP 2" by adding cephamycin-type antibiotics to the medium and consequently acquired resistance to methicillin.	Cephamycins	326-336	AT695_RS10295	Staphylococcus aureus	96-101
2232271-4	1990	High-level MRSA contained a larger amount of PBP 2" than moderate-level MRSA, and the amount of PBP 2" decreased by increasing the temperature of the culture; the extent of decrease was larger in a strain which was sensitive at 37 degrees C than a strain which exerted relatively high level resistance even at 40 degrees C. A cephamycin-resistant, methicillin-sensitive strain began to synthesize PBP 2" by adding cephamycin-type antibiotics to the medium and consequently acquired resistance to methicillin.	Cephamycins	326-336	AT695_RS10295	Staphylococcus aureus	96-101
2232271-4	1990	High-level MRSA contained a larger amount of PBP 2" than moderate-level MRSA, and the amount of PBP 2" decreased by increasing the temperature of the culture; the extent of decrease was larger in a strain which was sensitive at 37 degrees C than a strain which exerted relatively high level resistance even at 40 degrees C. A cephamycin-resistant, methicillin-sensitive strain began to synthesize PBP 2" by adding cephamycin-type antibiotics to the medium and consequently acquired resistance to methicillin.	Cephamycins	414-424	AT695_RS10295	Staphylococcus aureus	96-101
2232271-4	1990	High-level MRSA contained a larger amount of PBP 2" than moderate-level MRSA, and the amount of PBP 2" decreased by increasing the temperature of the culture; the extent of decrease was larger in a strain which was sensitive at 37 degrees C than a strain which exerted relatively high level resistance even at 40 degrees C. A cephamycin-resistant, methicillin-sensitive strain began to synthesize PBP 2" by adding cephamycin-type antibiotics to the medium and consequently acquired resistance to methicillin.	Cephamycins	414-424	AT695_RS10295	Staphylococcus aureus	96-101
34566340-1	2021	Background and Aim: Extended-spectrum beta-lactamase (ESBL) is an enzyme produced by the family of Enterobacteriaceae, especially Escherichia coli and Klebsiella pneumoniae, which can hydrolyzebeta-lactam antibiotics, such as penicillins, cephalosporins, cephamycin, and carbapenem.	Cephamycins	255-265	EsbL	Escherichia coli	20-52
3499862-0	1987	Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2.	Cephamycins	28-38	AT695_RS10295	Staphylococcus aureus	116-144
1956298-1	1991	The class B, metallo-beta-lactamase genes ccrA (carbapenem- and cephamycin resistance) from three Bacteroides fragilis isolates--QMCN3, QMCN4, and TAL3636--were cloned and expressed in Escherichia coli.	Cephamycins	64-74	beta-lactamase	Escherichia coli	21-35
2599989-4	1989	The clones that constitutively synthesized PBP 2" arose from the cephamycin-resistant strains at a frequency of 10(-5).	Cephamycins	65-75	AT695_RS10295	Staphylococcus aureus	43-48
6581342-2	1983	Following the intravenous administration of 2.0 g of CTT, T 1/2 beta in serum was 3.1 hours and longer than the previous cephamycin antibiotics.	Cephamycins	121-131	interleukin 1 receptor like 1	Homo sapiens	58-68
6604823-5	1983	Thus, it was confirmed that the cephamycin antibiotics were stable to beta-lactamase.	Cephamycins	32-42	beta-lactamase TEM-1	Haemophilus influenzae	70-84
32740783-1	2020	AmpC is a type of beta-lactamase enzyme produced by bacteria; these enzymes are classified in Class C and Group 1, and these confer resistance to cephamycin.	Cephamycins	146-156	beta-lactamase	Escherichia coli	0-4