PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7854116-3	1994	The sequence of the E7946 tcpA gene revealed that the mature El Tor TcpA pilin has the same number of residues as, and is 82% identical to, TcpA of classical biotype strain O395.	chlorfenac	26-30	tortured	Mus musculus	64-67
8965675-1	1996	We have previously shown that insertional inactivation of tcpA, the gene encoding the major pilin subunit of the toxin-coregulated pilus (TCP), renders Vibrio cholerae O1 strains of El Tor biotype virtually avirulent in the infant mouse cholera model (IMCM).	chlorfenac	58-62	RAR related orphan receptor C	Homo sapiens	185-188
8965675-4	1996	An attempt to complement the delta tcpA mutants by providing a functional El Tor tcpA gene in trans was only partially successful.	chlorfenac	35-39	RAR related orphan receptor C	Homo sapiens	77-80
8965675-5	1996	Sera raised against El Tor TcpA were able to passively protect infant mice against challenge with TCP-positive strains of homologous biotype and were also protective against isolates of the novel O139 serovar.	chlorfenac	27-31	RAR related orphan receptor C	Homo sapiens	23-26
17084586-6	2007	While increased expression of IL-1beta mRNA was observed in the macrophages exposed to each test compound, IL-1beta protein production was detected in cell lysates after treatment with TCPP, TCPA and HCPA for 24h (concentration range of 150-350 microM) as well as for 2h (450-650 microM).	chlorfenac	191-195	interleukin 1 beta	Mus musculus	107-115
15771251-3	2005	The appearance of pathogenic properties in cholera vibrios for the first time causing a local outbreak of cholera in 1937 is connected with the acquisition of VPI and CTX that carried genes tcpA and ctx-AB, respectively, which are responsible for the colonization of small intestine and encode the production of cholera toxin.	chlorfenac	190-194	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	167-170
15771251-3	2005	The appearance of pathogenic properties in cholera vibrios for the first time causing a local outbreak of cholera in 1937 is connected with the acquisition of VPI and CTX that carried genes tcpA and ctx-AB, respectively, which are responsible for the colonization of small intestine and encode the production of cholera toxin.	chlorfenac	190-194	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	199-202
12951258-3	2003	In this paper, we report in vitro studies showing that independent Mop mutants of strain 3083 are significantly attenuated (approximately 40-fold) in cholera toxin (CT) production and have significantly increased motility and biofilm forming ability but appear to be unaffected in TcpA, hemagglutinin protease and hemolysin compared to their parent.	chlorfenac	281-285	opioid receptor mu 1	Homo sapiens	67-70
7854116-3	1994	The sequence of the E7946 tcpA gene revealed that the mature El Tor TcpA pilin has the same number of residues as, and is 82% identical to, TcpA of classical biotype strain O395.	chlorfenac	68-72	tortured	Mus musculus	64-67
7854116-3	1994	The sequence of the E7946 tcpA gene revealed that the mature El Tor TcpA pilin has the same number of residues as, and is 82% identical to, TcpA of classical biotype strain O395.	chlorfenac	140-144	tortured	Mus musculus	64-67
7854116-5	1994	In a functional analysis, the cloned gene was used to construct an El Tor mutant strain containing an insertion in tcpA.	chlorfenac	115-119	tortured	Mus musculus	70-73
23954417-6	2013	All 10 isolates contained the repeat in the toxin gene rtxC, an El Tor biotype-specific marker, and the El Tor toxin-coregulated pili subunit A gene tcpA, showing the El Tor traits of these isolates.	chlorfenac	149-153	RAR related orphan receptor C	Homo sapiens	107-110
6231716-5	1984	TCPA has a molecular weight of 15,000 daltons and shows the same elution profile as IL-2.	chlorfenac	0-4	interleukin 2	Rattus norvegicus	84-88
26702542-1	2016	We report the stereoselective synthesis and biological activity of a novel series of tranylcypromine (TCPA) derivatives (14a-k, 15, 16), potent inhibitors of KDM1A.	chlorfenac	102-106	lysine (K)-specific demethylase 1A	Mus musculus	158-163
26056384-4	2015	Besides identifying most of the genes known to modulate tcpA expression, the screen yielded ptsI and ptsH, which encode the enzyme I (EI) and Hpr components of the V. cholerae phosphoenolpyruvate phosphotransferase system (PTS).	chlorfenac	56-60	haptoglobin-related protein	Homo sapiens	142-145
25474636-4	2014	We developed a TcpA holotoxin-like chimera (TcpA-A2-CTB) to elicit both anti-TcpA and anti-CTB antibodies and evaluated its immunogenicity and protective efficacy in the infant mouse model of cholera.	chlorfenac	15-19	chitobiase	Mus musculus	52-55
25474636-4	2014	We developed a TcpA holotoxin-like chimera (TcpA-A2-CTB) to elicit both anti-TcpA and anti-CTB antibodies and evaluated its immunogenicity and protective efficacy in the infant mouse model of cholera.	chlorfenac	15-19	chitobiase	Homo sapiens	91-94
2417965-3	1986	Preincubation of normal E+ lymphocytes with some TCPA+, PIA(-)-LCM for 48 hr leads to IL2-induced cell proliferation in the absence of any other stimulation.	chlorfenac	49-53	RPTOR independent companion of MTOR complex 2	Homo sapiens	56-59
2417965-3	1986	Preincubation of normal E+ lymphocytes with some TCPA+, PIA(-)-LCM for 48 hr leads to IL2-induced cell proliferation in the absence of any other stimulation.	chlorfenac	49-53	interleukin 2	Homo sapiens	86-89
33913531-1	2021	The aim of this study was to assess the modulatory effect of TcpA in the expression of CEACAM1 adhesin molecule and IL-1, IL-8 and TNFalpha pro-inflammatiory cytokines in the co-culture model of Caco-2/PBMC that can mimic the intestinal milieu.	chlorfenac	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
33913531-1	2021	The aim of this study was to assess the modulatory effect of TcpA in the expression of CEACAM1 adhesin molecule and IL-1, IL-8 and TNFalpha pro-inflammatiory cytokines in the co-culture model of Caco-2/PBMC that can mimic the intestinal milieu.	chlorfenac	61-65	tumor necrosis factor	Homo sapiens	131-139
33913531-9	2021	In conclusion, V.cholerae TcpA induces statistically significant dose-dependent stimulatory effect on TNFalpha, IL-1 and IL-8 pro-inflammatory cytokines expression.	chlorfenac	26-30	tumor necrosis factor	Homo sapiens	102-110
33913531-9	2021	In conclusion, V.cholerae TcpA induces statistically significant dose-dependent stimulatory effect on TNFalpha, IL-1 and IL-8 pro-inflammatory cytokines expression.	chlorfenac	26-30	interleukin 1 alpha	Homo sapiens	112-116
33913531-9	2021	In conclusion, V.cholerae TcpA induces statistically significant dose-dependent stimulatory effect on TNFalpha, IL-1 and IL-8 pro-inflammatory cytokines expression.	chlorfenac	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
25474636-4	2014	We developed a TcpA holotoxin-like chimera (TcpA-A2-CTB) to elicit both anti-TcpA and anti-CTB antibodies and evaluated its immunogenicity and protective efficacy in the infant mouse model of cholera.	chlorfenac	44-48	chitobiase	Mus musculus	52-55
25474636-4	2014	We developed a TcpA holotoxin-like chimera (TcpA-A2-CTB) to elicit both anti-TcpA and anti-CTB antibodies and evaluated its immunogenicity and protective efficacy in the infant mouse model of cholera.	chlorfenac	44-48	chitobiase	Homo sapiens	91-94
25474636-4	2014	We developed a TcpA holotoxin-like chimera (TcpA-A2-CTB) to elicit both anti-TcpA and anti-CTB antibodies and evaluated its immunogenicity and protective efficacy in the infant mouse model of cholera.	chlorfenac	44-48	chitobiase	Mus musculus	52-55
25474636-4	2014	We developed a TcpA holotoxin-like chimera (TcpA-A2-CTB) to elicit both anti-TcpA and anti-CTB antibodies and evaluated its immunogenicity and protective efficacy in the infant mouse model of cholera.	chlorfenac	44-48	chitobiase	Homo sapiens	91-94
25474636-5	2014	Adult female CD-1 mice were immunized intraperitoneally three times with the TcpA-A2-CTB chimera and compared with similar groups immunized with a TcpA+CTB mixture, TcpA alone, TcpA with Salmonella typhimurium flagellin subunit FliC as adjuvant, or CTB alone.	chlorfenac	77-81	chitobiase	Mus musculus	85-88
25474636-8	2014	All pups from dams immunized with the TcpA-A2-CTB chimera or the TcpA+CTB mixture survived at both challenge doses.	chlorfenac	38-42	chitobiase	Mus musculus	46-49
25474636-11	2014	Weight loss analysis showed that only immunization of dams with TcpA-A2-CTB chimera or TcpA+CTB mixture protected their pups against excess weight loss from severe diarrhea.	chlorfenac	64-68	chitobiase	Mus musculus	72-75
25065827-3	2014	We tested tcpA gene frequency in three natural pristine soils with different 246-TCP degradation capacity.	chlorfenac	10-14	serine peptidase inhibitor Kazal type 1	Homo sapiens	81-84
25065827-5	2014	As the soil in each mesocosm originated from a spatially separate field plot, changes in tcpA gene frequency affected 246-TCP degradation over a range of soil origins.	chlorfenac	89-93	serine peptidase inhibitor Kazal type 1	Homo sapiens	122-125
23954417-6	2013	All 10 isolates contained the repeat in the toxin gene rtxC, an El Tor biotype-specific marker, and the El Tor toxin-coregulated pili subunit A gene tcpA, showing the El Tor traits of these isolates.	chlorfenac	149-153	RAR related orphan receptor C	Homo sapiens	107-110
21880975-7	2011	Particularly, El Tor variant MQ1795, which produced the highest level of CT and very high levels of TcpA and ToxT, demonstrated hypervirulence compared to the virulence of El Tor wild-type strains in the infant mouse cholera model.	chlorfenac	100-104	RAR related orphan receptor C	Homo sapiens	17-20