PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21854579-10	2011	Furthermore, the cytotoxicity assay and gene expression analysis showed that the part played by YAP1 and CTT1 genes in cell resistance to PHMB is unrelated to oxidative stress response.	polihexanide	138-142	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	96-100
23020271-8	2012	Flow cytometric analysis revealed an increase of Annexin V and active caspases expression of human chondrocytes after incubation with polyhexanide, hydrogen peroxide, and chlorhexidine.	polihexanide	134-146	annexin A5	Homo sapiens	49-58
21842299-12	2012	CONCLUSIONS: Use of polyhexamethylene biguanide-impregnated gauze can reduce the risk of pin tract infection in external fixation.	polihexanide	20-47	dynein light chain LC8-type 1	Homo sapiens	89-92
21956063-9	2011	Flow cytometric analysis demonstrated an increase of annexin V and active caspases expression of human chondrocytes after incubation with polyhexanide.	polihexanide	138-150	annexin A5	Homo sapiens	53-62
21854579-10	2011	Furthermore, the cytotoxicity assay and gene expression analysis showed that the part played by YAP1 and CTT1 genes in cell resistance to PHMB is unrelated to oxidative stress response.	polihexanide	138-142	catalase T	Saccharomyces cerevisiae S288C	105-109
21854579-12	2011	CONCLUSION: The PHMB treatment of the yeast cells activates the PKC1/Slt2 (CWI) pathway.	polihexanide	16-20	protein kinase C	Saccharomyces cerevisiae S288C	64-68
21854579-12	2011	CONCLUSION: The PHMB treatment of the yeast cells activates the PKC1/Slt2 (CWI) pathway.	polihexanide	16-20	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	69-73
2191538-3	1990	Osmotically active "small" Chr A fragments (below 30 kDa) were conspicuous in lysates containing cocktails of leupeptin, pepstatin A, pHMB, PMSF and aprotinin.	polihexanide	134-138	chromogranin A	Bos taurus	27-32
14704911-3	2004	RESULTS: Lysozyme deposition on etafilcon lenses was greater following disinfection with the PHMB-based system (1551 +/- 371 micro g/lens vs 935 +/- 271 micro g/lens; p < 0.001).	polihexanide	93-97	lysozyme	Homo sapiens	9-17
14704911-5	2004	For both materials, the percentage of denatured lysozyme was greater when they were exposed to the PHMB-based system (28 vs 21%; p = 0.05 (etafilcon) and 57 vs 40%; p = 0.04 (balafilcon)).	polihexanide	99-103	lysozyme	Homo sapiens	48-56
19895651-2	2010	METHODS AND RESULTS: When tested in a standard suspension test, two polyhexamethylene biguanides (PHMB), VANTOCIL TG and COSMOCIL CQ, reduced the viability of MS2 by only 1-2 log(10) PFU ml(-1).	polihexanide	68-96	MS2	Homo sapiens	159-162
19895651-2	2010	METHODS AND RESULTS: When tested in a standard suspension test, two polyhexamethylene biguanides (PHMB), VANTOCIL TG and COSMOCIL CQ, reduced the viability of MS2 by only 1-2 log(10) PFU ml(-1).	polihexanide	98-102	MS2	Homo sapiens	159-162
19895651-2	2010	METHODS AND RESULTS: When tested in a standard suspension test, two polyhexamethylene biguanides (PHMB), VANTOCIL TG and COSMOCIL CQ, reduced the viability of MS2 by only 1-2 log(10) PFU ml(-1).	polihexanide	121-132	MS2	Homo sapiens	159-162
19895651-3	2010	Exposure time up to 30 min did not affect the activity of the biguanides, although both PHMB were shown to strongly interact with MS2 proteins.	polihexanide	88-92	MS2	Homo sapiens	130-133
1515063-5	1992	Aminopeptidase was shown to be a monomeric protein of M(r) approximately 110000 and of pI approximately 4.8, activated by Co2+ and inhibited by EDTA, pHMB, amastatin, bestatin and puromycin.	polihexanide	150-154	carboxypeptidase Q	Homo sapiens	0-14
32678912-4	2020	IgE to the biguanide and/or hexamethylene structure was investigated with PHMB ImmunoCAP (n=32) and by basophil activation tests (BAT) with CHX and ALX (n=37).	polihexanide	74-78	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
2939301-4	1986	The Mg2+-ATPase and K+-EDTA ATPase activities are strongly inhibited by the sulfhydryl blocking reagent, pHMB.	polihexanide	105-109	dynein axonemal heavy chain 8	Homo sapiens	9-15
2939301-4	1986	The Mg2+-ATPase and K+-EDTA ATPase activities are strongly inhibited by the sulfhydryl blocking reagent, pHMB.	polihexanide	105-109	dynein axonemal heavy chain 8	Homo sapiens	28-34
32678912-2	2020	The cross-reactivity of patients with IgE-mediated CHX-allergy with other disinfectants, which share structural similarities with CHX like polyhexanide (polyhexamethylene biguanide; PHMB), alexidine (ALX) or octenidine (OCT) is unknown.	polihexanide	139-151	immunoglobulin heavy constant epsilon	Homo sapiens	38-41
32678912-2	2020	The cross-reactivity of patients with IgE-mediated CHX-allergy with other disinfectants, which share structural similarities with CHX like polyhexanide (polyhexamethylene biguanide; PHMB), alexidine (ALX) or octenidine (OCT) is unknown.	polihexanide	153-180	immunoglobulin heavy constant epsilon	Homo sapiens	38-41
32678912-2	2020	The cross-reactivity of patients with IgE-mediated CHX-allergy with other disinfectants, which share structural similarities with CHX like polyhexanide (polyhexamethylene biguanide; PHMB), alexidine (ALX) or octenidine (OCT) is unknown.	polihexanide	182-186	immunoglobulin heavy constant epsilon	Homo sapiens	38-41
32678912-10	2020	A further patient reacted primarily with OCT, and showed IgE cross-reactivity with CHX, ALX and PHMB.	polihexanide	96-100	immunoglobulin heavy constant epsilon	Homo sapiens	57-60
32678912-13	2020	IgE-reactivities with the biguanide or hexamethylene components of other disinfectants (ALX, PHMB) can be detected by SPT, PHMB-ImmunoCAP and ALX-BAT in 15-33% of CHX allergic patients.	polihexanide	93-97	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
32678912-13	2020	IgE-reactivities with the biguanide or hexamethylene components of other disinfectants (ALX, PHMB) can be detected by SPT, PHMB-ImmunoCAP and ALX-BAT in 15-33% of CHX allergic patients.	polihexanide	123-127	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
31130579-0	2019	Determination of Polyhexamethylene Biguanide Utilizing a Glucose Oxidase Enzymatic Reaction.	polihexanide	17-44	hydroxyacid oxidase 1	Homo sapiens	57-72
33202979-12	2020	PHMB combined with TLR4a shows promise as a potential anti-L. infantum drug combination, as well as inducer of proinflammatory response, as demonstrated by decreased infection and increased TNF-alpha production.	polihexanide	0-4	tumor necrosis factor	Canis lupus familiaris	190-199
31130579-3	2019	The promotion effect arose from a polyion complex formation between polycationic PHMB and polyanionic GOx.	polihexanide	81-85	hydroxyacid oxidase 1	Homo sapiens	102-105
29248316-11	2018	Exposing the cells to borate buffer and PHMB caused an increase in the release of TNF-alpha p < 0.05.	polihexanide	40-44	tumor necrosis factor	Homo sapiens	82-91
31279155-7	2019	Polihexanide also enhanced the innate immune response by increasing the gene expression levels of antimicrobial peptides such as human beta-defensin 2, human beta-defensin 3, psoriasin and ribonuclease 7.	polihexanide	0-12	defensin beta 4B	Homo sapiens	135-150
31279155-7	2019	Polihexanide also enhanced the innate immune response by increasing the gene expression levels of antimicrobial peptides such as human beta-defensin 2, human beta-defensin 3, psoriasin and ribonuclease 7.	polihexanide	0-12	defensin beta 103B	Homo sapiens	158-173
31279155-7	2019	Polihexanide also enhanced the innate immune response by increasing the gene expression levels of antimicrobial peptides such as human beta-defensin 2, human beta-defensin 3, psoriasin and ribonuclease 7.	polihexanide	0-12	ribonuclease A family member 7	Homo sapiens	189-203
27746371-0	2017	In vitro inflammatory effects of polyhexamethylene biguanide through NF-kappaB activation in A549 cells.	polihexanide	33-60	nuclear factor kappa B subunit 1	Homo sapiens	69-78
27746371-5	2017	A549 cells exposed to PHMB showed decreased viability, reactive oxygen species (ROS) generation, inflammatory cytokine secretion, and nuclear factor kappa B (NF-kappaB) activation.	polihexanide	22-26	nuclear factor kappa B subunit 1	Homo sapiens	134-156
27746371-5	2017	A549 cells exposed to PHMB showed decreased viability, reactive oxygen species (ROS) generation, inflammatory cytokine secretion, and nuclear factor kappa B (NF-kappaB) activation.	polihexanide	22-26	nuclear factor kappa B subunit 1	Homo sapiens	158-167
27746371-7	2017	PHMB triggered inflammatory cytokine secretion and NF-kappaB activation by modulating the degradation of IkappaB-alpha and the accumulation of nuclear p65.	polihexanide	0-4	nuclear factor kappa B subunit 1	Homo sapiens	51-60
27746371-7	2017	PHMB triggered inflammatory cytokine secretion and NF-kappaB activation by modulating the degradation of IkappaB-alpha and the accumulation of nuclear p65.	polihexanide	0-4	NFKB inhibitor alpha	Homo sapiens	105-118
27746371-7	2017	PHMB triggered inflammatory cytokine secretion and NF-kappaB activation by modulating the degradation of IkappaB-alpha and the accumulation of nuclear p65.	polihexanide	0-4	RELA proto-oncogene, NF-kB subunit	Homo sapiens	151-154
27746371-9	2017	Moreover, IL-8 production induced by PHMB was completely suppressed by a NF-kappaB inhibitor, but not by a ROS scavenger.	polihexanide	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
27746371-9	2017	Moreover, IL-8 production induced by PHMB was completely suppressed by a NF-kappaB inhibitor, but not by a ROS scavenger.	polihexanide	37-41	nuclear factor kappa B subunit 1	Homo sapiens	73-82
27746371-10	2017	In conclusion, we suggest that PHMB induces the inflammatory responses via the NF-kappaB signaling pathway.	polihexanide	31-35	nuclear factor kappa B subunit 1	Homo sapiens	79-88
27307987-5	2016	The protocol makes use of polyhexanide-based products, in view of reported qac-mediated resistance to chlorhexidine in S. aureus and MRSA.	polihexanide	26-38	solute carrier family 9 member A6	Homo sapiens	133-137
25093465-9	2015	Polyhexanide, but not chlorhexidine, caused human osteoblasts to secrete various interleukins (1beta, 6, and 7), interferon gamma, tumor necrosis factor alpha, vascular endothelial growth factor, eotaxin, fibroblast growth factor basic, and granulocyte macrophage colony-stimulating factor as quantified by multiplex suspension array.	polihexanide	0-12	vascular endothelial growth factor A	Homo sapiens	160-194
26654738-11	2015	Although the CRP levels were reduced significantly within group comparisons in both groups (p<0.001), it was significantly lower after 12 days (p<0.05) in the PHMB group compared with the RLS group.	polihexanide	165-169	C-reactive protein	Homo sapiens	13-16
25093465-9	2015	Polyhexanide, but not chlorhexidine, caused human osteoblasts to secrete various interleukins (1beta, 6, and 7), interferon gamma, tumor necrosis factor alpha, vascular endothelial growth factor, eotaxin, fibroblast growth factor basic, and granulocyte macrophage colony-stimulating factor as quantified by multiplex suspension array.	polihexanide	0-12	C-C motif chemokine ligand 11	Homo sapiens	196-203
25093465-9	2015	Polyhexanide, but not chlorhexidine, caused human osteoblasts to secrete various interleukins (1beta, 6, and 7), interferon gamma, tumor necrosis factor alpha, vascular endothelial growth factor, eotaxin, fibroblast growth factor basic, and granulocyte macrophage colony-stimulating factor as quantified by multiplex suspension array.	polihexanide	0-12	colony stimulating factor 2	Homo sapiens	205-289
25111876-11	2014	Instead, from concentrations of 20 to 100 microg/mL, PHMB kills cells of all types in less than 3 h. The expression of genes involved in the mechanisms of cell death induced by PHMB, including p53, the pro apoptotic gene bax and others, the anti-apoptotic bcl-2 and caspase-3 has been evaluated by RT-PCR.	polihexanide	53-57	tumor protein p53	Homo sapiens	193-196
24982214-2	2014	We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS.	polihexanide	21-33	interleukin 5	Homo sapiens	113-117
24982214-2	2014	We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS.	polihexanide	21-33	C-C motif chemokine ligand 26	Homo sapiens	122-131
24982214-2	2014	We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS.	polihexanide	21-33	matrix metallopeptidase 9	Homo sapiens	177-182
24982214-7	2014	But there exists statistically significant evidence that the self-amplification process of eosinophils via eotaxin-3 could be influenced by the administration of polihexanide.	polihexanide	162-174	C-C motif chemokine ligand 26	Homo sapiens	107-116
25320343-7	2014	l-Lactate-dependent proton export was blocked almost completely by pHMB, a specific inhibitor of MCT1 and MCT4.	polihexanide	67-71	solute carrier family 16 member 1	Homo sapiens	97-101
25320343-7	2014	l-Lactate-dependent proton export was blocked almost completely by pHMB, a specific inhibitor of MCT1 and MCT4.	polihexanide	67-71	solute carrier family 16 member 3	Homo sapiens	106-110
24302374-10	2013	One small blinded study of 38 patients found that the risk of pin site infection was significantly reduced with polyhexamethylene biguanide (PHMB) gauze when compared to plain gauze (RR 0.23, 95% CI 0.12 to 0.44) (infection rate of 1% in the PHMB group and 4.5% in the control group) but this study was at high risk of bias as the unit of analysis was observations rather than patients.	polihexanide	112-139	dynein light chain LC8-type 1	Homo sapiens	62-65
24302374-10	2013	One small blinded study of 38 patients found that the risk of pin site infection was significantly reduced with polyhexamethylene biguanide (PHMB) gauze when compared to plain gauze (RR 0.23, 95% CI 0.12 to 0.44) (infection rate of 1% in the PHMB group and 4.5% in the control group) but this study was at high risk of bias as the unit of analysis was observations rather than patients.	polihexanide	141-145	dynein light chain LC8-type 1	Homo sapiens	62-65