PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30801760-6	2019	Here we show that DNBS induced SGC activation in mouse DRG, as assayed by glial fibrillary acidic protein upregulation.	2,4-dinitrofluorobenzene sulfonic acid	18-22	serglycin	Mus musculus	31-34
30711419-3	2019	We evaluated the development of the physiopathology of the DNBS induced colitis in Fpr1 KO mice on the C57BL/6 genetic background compared to C57BL/6 genetic background animals.	2,4-dinitrofluorobenzene sulfonic acid	59-63	formyl peptide receptor 1	Mus musculus	83-87
29907915-8	2019	RESULTS: Guanosine, in a dose-dependent manner, significantly ameliorated the severity of DNBS-induced colitis, reducing body weight loss and diarrhea incidence, preventing the DNBS-induced macroscopic and microscopic damage to the colonic mucosa, and the MPO increase.	2,4-dinitrofluorobenzene sulfonic acid	177-181	myeloperoxidase	Rattus norvegicus	256-259
30175880-6	2019	The minimum concentration of dibutyl succinate to inhibit germination of conidia of the cause of anthracnose, Colletotrichum acutatum, was 4 mg mL-1 .	2,4-dinitrofluorobenzene sulfonic acid	29-46	L1 cell adhesion molecule	Mus musculus	144-148
30175880-7	2019	Dibutyl succinate at 2 microg mL-1 inhibited mycelial growth.	2,4-dinitrofluorobenzene sulfonic acid	0-17	L1 cell adhesion molecule	Mus musculus	30-34
30711419-5	2019	DNBS-treated Fpr1 KO mice showed a i) reduction in weight loss, ii) lower extent of colon injury and iii) an increase in MPO activity.	2,4-dinitrofluorobenzene sulfonic acid	0-4	formyl peptide receptor 1	Mus musculus	13-17
30711419-5	2019	DNBS-treated Fpr1 KO mice showed a i) reduction in weight loss, ii) lower extent of colon injury and iii) an increase in MPO activity.	2,4-dinitrofluorobenzene sulfonic acid	0-4	myeloperoxidase	Mus musculus	121-124
30711419-7	2019	In addition, the colon of DNBS-injected Fpr1 KO mice displayed a lower degree of expression of Bax and higher expression of Bcl-2 compared correspondent WT mice.	2,4-dinitrofluorobenzene sulfonic acid	26-30	formyl peptide receptor 1	Mus musculus	40-44
30711419-7	2019	In addition, the colon of DNBS-injected Fpr1 KO mice displayed a lower degree of expression of Bax and higher expression of Bcl-2 compared correspondent WT mice.	2,4-dinitrofluorobenzene sulfonic acid	26-30	BCL2-associated X protein	Mus musculus	95-98
30711419-7	2019	In addition, the colon of DNBS-injected Fpr1 KO mice displayed a lower degree of expression of Bax and higher expression of Bcl-2 compared correspondent WT mice.	2,4-dinitrofluorobenzene sulfonic acid	26-30	B cell leukemia/lymphoma 2	Mus musculus	124-129
30711419-8	2019	Finally, intravital microscopy investigation of the microcirculation post-DNBS instillation revealed a lower degree of neutrophil-endothelial cell rolling and adhesion - mediated by P-selectin and ICAM-1 - in Fpr1 KO mice.	2,4-dinitrofluorobenzene sulfonic acid	74-78	selectin, platelet	Mus musculus	182-192
30711419-8	2019	Finally, intravital microscopy investigation of the microcirculation post-DNBS instillation revealed a lower degree of neutrophil-endothelial cell rolling and adhesion - mediated by P-selectin and ICAM-1 - in Fpr1 KO mice.	2,4-dinitrofluorobenzene sulfonic acid	74-78	intercellular adhesion molecule 1	Mus musculus	197-203
30711419-8	2019	Finally, intravital microscopy investigation of the microcirculation post-DNBS instillation revealed a lower degree of neutrophil-endothelial cell rolling and adhesion - mediated by P-selectin and ICAM-1 - in Fpr1 KO mice.	2,4-dinitrofluorobenzene sulfonic acid	74-78	formyl peptide receptor 1	Mus musculus	209-213
29351392-8	2018	Protection against DNBS-induced colitis was accompanied by an increased capacity to make interleukin (IL)-4 and IL-10.	2,4-dinitrofluorobenzene sulfonic acid	19-23	interleukin 4	Mus musculus	89-107
29351392-8	2018	Protection against DNBS-induced colitis was accompanied by an increased capacity to make interleukin (IL)-4 and IL-10.	2,4-dinitrofluorobenzene sulfonic acid	19-23	interleukin 10	Mus musculus	112-117
29098729-0	2017	Clinical severity in Japanese patients with neurofibromatosis 1 based on DNB classification.	2,4-dinitrofluorobenzene sulfonic acid	73-76	neurofibromin 1	Homo sapiens	44-63
29556732-1	2018	In this work, a CL-20/DNB cocrystal explosive model was established and six different kinds of fluoropolymers, i.e., PVDF, PCTFE, F2311, F2312, F2313 and F2314 were added into the (1 0 0), (0 1 0), (0 0 1) crystal orientations to obtain the corresponding polymer bonded explosives (PBXs).	2,4-dinitrofluorobenzene sulfonic acid	22-25	epithelial membrane protein 1	Homo sapiens	16-21
29247178-5	2017	In the myenteric plexus of rats with 2, 4-dinitrobenzene sulfonic (DNBS)-induced colitis HABP staining was altered in the perineuronal space, while both HABP staining and HA levels increased in the muscularis propria.	2,4-dinitrofluorobenzene sulfonic acid	67-71	hyaluronan binding protein 2	Rattus norvegicus	89-93
28160390-0	2017	Angiotensin II type II receptors and colonic dysmotility in 2,4-dinitrofluorobenzenesulfonic acid-induced colitis in rats.	2,4-dinitrofluorobenzene sulfonic acid	60-97	angiotensinogen	Rattus norvegicus	0-14
28322053-2	2017	Ru-2 is weakly luminescent due to the effective photoinduced electron transfer (PET) from Ru(II) luminophore to electron acceptor, 2,4-dinitrobenzene-sulfonyl (DNBS).	2,4-dinitrofluorobenzene sulfonic acid	160-164	doublecortin domain containing 2	Homo sapiens	0-4
28193209-5	2017	Indeed, it was demonstrated that a recombinant strain of Lactococcus lactis expressing human PAP (LL-PAP) could prevent and improve murine DNBS-induced colitis, an inflammatory bowel disease (IBD) that causes severe inflammation of the colon.	2,4-dinitrofluorobenzene sulfonic acid	139-143	regenerating family member 3 alpha	Homo sapiens	93-96
28198622-6	2017	DNBS-induced colitis in mice was used to investigate Mn1 activity in vivo.	2,4-dinitrofluorobenzene sulfonic acid	0-4	meningioma 1	Mus musculus	53-56
28193209-5	2017	Indeed, it was demonstrated that a recombinant strain of Lactococcus lactis expressing human PAP (LL-PAP) could prevent and improve murine DNBS-induced colitis, an inflammatory bowel disease (IBD) that causes severe inflammation of the colon.	2,4-dinitrofluorobenzene sulfonic acid	139-143	regenerating family member 3 alpha	Homo sapiens	98-104
24215755-6	2014	KEY FINDINGS: Observations of the colon and IL-6 plasma level determination demonstrated that DNBS treatment led to stronger inflammation.	2,4-dinitrofluorobenzene sulfonic acid	94-98	interleukin 6	Mus musculus	44-48
27399273-8	2016	The activity in GCF from patients with periodontitis (clinically healthy sites: CH, deep bleeding sites: DB and deep non-bleeding sites: DNB) was significantly higher than those from healthy subjects (healthy sites: H).	2,4-dinitrofluorobenzene sulfonic acid	137-140	GC-rich sequence DNA-binding factor 2	Homo sapiens	16-19
27055194-6	2016	Also, IL-10 and markers of regulatory T cells were increased in IL-22-/- mice that displayed less DNBS (3 mg, ir.	2,4-dinitrofluorobenzene sulfonic acid	98-102	interleukin 22	Mus musculus	64-69
27055194-9	2016	Finally, treatment with anti-IL-25 antibodies exaggerated DNBS-induced colitis in IL-22-/- mice and blocked the anti-colitic effect of infection with H. diminuta.	2,4-dinitrofluorobenzene sulfonic acid	58-62	interleukin 25	Mus musculus	29-34
27055194-9	2016	Finally, treatment with anti-IL-25 antibodies exaggerated DNBS-induced colitis in IL-22-/- mice and blocked the anti-colitic effect of infection with H. diminuta.	2,4-dinitrofluorobenzene sulfonic acid	58-62	interleukin 22	Mus musculus	82-87
23494123-4	2013	DNBS-treated mice developed colitis; this was significantly less severe in mice receiving WT AAMs and less so in animals given IL-10(-/-) AAMs, indicating a role for IL-10 in the inhibition of DNBS-driven colitis.	2,4-dinitrofluorobenzene sulfonic acid	0-4	interleukin 10	Mus musculus	127-132
23373571-10	2013	In vivo, cannabichromene ameliorated DNBS-induced colonic inflammation, as revealed by histology, immunohistochemistry and myeloperoxidase activity.	2,4-dinitrofluorobenzene sulfonic acid	37-41	myeloperoxidase	Mus musculus	123-138
23494123-4	2013	DNBS-treated mice developed colitis; this was significantly less severe in mice receiving WT AAMs and less so in animals given IL-10(-/-) AAMs, indicating a role for IL-10 in the inhibition of DNBS-driven colitis.	2,4-dinitrofluorobenzene sulfonic acid	0-4	interleukin 10	Mus musculus	166-171
23494123-4	2013	DNBS-treated mice developed colitis; this was significantly less severe in mice receiving WT AAMs and less so in animals given IL-10(-/-) AAMs, indicating a role for IL-10 in the inhibition of DNBS-driven colitis.	2,4-dinitrofluorobenzene sulfonic acid	193-197	interleukin 10	Mus musculus	166-171
24453460-2	2011	The present study focused on electron transfer ability of resting state CaM-free nNOS in presence of dinitrobenzene isomers (DNBs).	2,4-dinitrofluorobenzene sulfonic acid	125-129	calmodulin 1	Homo sapiens	72-75
24459330-11	2013	CONCLUSIONS: PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis.	2,4-dinitrofluorobenzene sulfonic acid	131-135	coagulation factor II (thrombin) receptor	Mus musculus	13-17
24459330-11	2013	CONCLUSIONS: PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis.	2,4-dinitrofluorobenzene sulfonic acid	131-135	coagulation factor II (thrombin) receptor	Mus musculus	75-79
23469045-8	2013	Rivastigmine 1 and 2 mg given rectally to rats with colitis induced by rectal administration of 30 mg dintrobezene sulfonic acid (DNBS) also caused a dose related reduction in ChE activity in blood and colon, the number of ulcers and area of ulceration, levels of TNF-alpha and in MPO activity.	2,4-dinitrofluorobenzene sulfonic acid	130-134	butyrylcholinesterase	Rattus norvegicus	176-179
23469045-8	2013	Rivastigmine 1 and 2 mg given rectally to rats with colitis induced by rectal administration of 30 mg dintrobezene sulfonic acid (DNBS) also caused a dose related reduction in ChE activity in blood and colon, the number of ulcers and area of ulceration, levels of TNF-alpha and in MPO activity.	2,4-dinitrofluorobenzene sulfonic acid	130-134	tumor necrosis factor	Rattus norvegicus	264-273
23469045-8	2013	Rivastigmine 1 and 2 mg given rectally to rats with colitis induced by rectal administration of 30 mg dintrobezene sulfonic acid (DNBS) also caused a dose related reduction in ChE activity in blood and colon, the number of ulcers and area of ulceration, levels of TNF-alpha and in MPO activity.	2,4-dinitrofluorobenzene sulfonic acid	130-134	myeloperoxidase	Rattus norvegicus	281-284
24459330-10	2013	Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice.	2,4-dinitrofluorobenzene sulfonic acid	47-51	coagulation factor II (thrombin) receptor	Mus musculus	14-18
24459330-10	2013	Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice.	2,4-dinitrofluorobenzene sulfonic acid	47-51	coagulation factor II (thrombin) receptor	Mus musculus	76-80
24453460-2	2011	The present study focused on electron transfer ability of resting state CaM-free nNOS in presence of dinitrobenzene isomers (DNBs).	2,4-dinitrofluorobenzene sulfonic acid	125-129	nitric oxide synthase 1	Homo sapiens	81-85
17936526-6	2007	Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS.	2,4-dinitrofluorobenzene sulfonic acid	6-10	C-C motif chemokine receptor 5	Homo sapiens	78-82
24453460-4	2011	All the DNBs (o-, m-, p-) independently stimulated rates of NADPH ox by CaM-free nNOS and by nNOS-FP in isomer- and concentration-dependent manner.	2,4-dinitrofluorobenzene sulfonic acid	8-12	calmodulin 1	Homo sapiens	72-75
24453460-4	2011	All the DNBs (o-, m-, p-) independently stimulated rates of NADPH ox by CaM-free nNOS and by nNOS-FP in isomer- and concentration-dependent manner.	2,4-dinitrofluorobenzene sulfonic acid	8-12	nitric oxide synthase 1	Homo sapiens	81-85
24453460-4	2011	All the DNBs (o-, m-, p-) independently stimulated rates of NADPH ox by CaM-free nNOS and by nNOS-FP in isomer- and concentration-dependent manner.	2,4-dinitrofluorobenzene sulfonic acid	8-12	nitric oxide synthase 1	Homo sapiens	93-97
24453460-8	2011	All three DNBs greatly stimulated nNOS and nNOS-FP catalyzed AcCyt-cred that was significantly inhibited by SOD demonstrating [Formula: see text] formation.	2,4-dinitrofluorobenzene sulfonic acid	10-14	nitric oxide synthase 1	Homo sapiens	34-38
24453460-8	2011	All three DNBs greatly stimulated nNOS and nNOS-FP catalyzed AcCyt-cred that was significantly inhibited by SOD demonstrating [Formula: see text] formation.	2,4-dinitrofluorobenzene sulfonic acid	10-14	nitric oxide synthase 1	Homo sapiens	43-47
24453460-9	2011	Thus, in presence of DNBs, resting-state CaM-deficient nNOS efficiently transfers electrons generating [Formula: see text], inferring that additional metabolic roles for nNOS exist that are not yet explored.	2,4-dinitrofluorobenzene sulfonic acid	21-25	calmodulin 1	Homo sapiens	41-44
24453460-9	2011	Thus, in presence of DNBs, resting-state CaM-deficient nNOS efficiently transfers electrons generating [Formula: see text], inferring that additional metabolic roles for nNOS exist that are not yet explored.	2,4-dinitrofluorobenzene sulfonic acid	21-25	nitric oxide synthase 1	Homo sapiens	55-59
19886745-4	2010	Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight.	2,4-dinitrofluorobenzene sulfonic acid	16-20	carbonic anhydrase 1	Rattus norvegicus	52-55
18429971-7	2008	Four days after DNBS administration, colon TNF-alpha production was associated with colon damage.	2,4-dinitrofluorobenzene sulfonic acid	16-20	tumor necrosis factor	Rattus norvegicus	43-52
18429971-8	2008	Biochemical methods and zymography were used to analyse MMP-9 and MMP-2 activities in colon tissues from DNBS-injured rats.	2,4-dinitrofluorobenzene sulfonic acid	105-109	matrix metallopeptidase 9	Rattus norvegicus	56-61
18429971-8	2008	Biochemical methods and zymography were used to analyse MMP-9 and MMP-2 activities in colon tissues from DNBS-injured rats.	2,4-dinitrofluorobenzene sulfonic acid	105-109	matrix metallopeptidase 2	Rattus norvegicus	66-71
18429971-10	2008	Melatonin also reduced proMMP-9 and MMP-2 activities that were induced in the colon tissues by DNBS administration.	2,4-dinitrofluorobenzene sulfonic acid	95-99	matrix metallopeptidase 2	Rattus norvegicus	36-41
18429971-12	2008	We conclude that melatonin"s ability to reduce DNBS-induced colon injury in rats is related to a reduction in proMMP-9 and MMP-2 activities and expression.	2,4-dinitrofluorobenzene sulfonic acid	47-51	matrix metallopeptidase 2	Rattus norvegicus	123-128
18645606-8	2008	Expression of Bcl-2 was maintained in both anti-TNF treatments and TNFR-1(-/-) mice.DNB colitis induced a very early, rapid increase of enterocyte apoptosis.	2,4-dinitrofluorobenzene sulfonic acid	84-87	B cell leukemia/lymphoma 2	Mus musculus	14-19
18645606-8	2008	Expression of Bcl-2 was maintained in both anti-TNF treatments and TNFR-1(-/-) mice.DNB colitis induced a very early, rapid increase of enterocyte apoptosis.	2,4-dinitrofluorobenzene sulfonic acid	84-87	tumor necrosis factor	Mus musculus	48-51
18645606-8	2008	Expression of Bcl-2 was maintained in both anti-TNF treatments and TNFR-1(-/-) mice.DNB colitis induced a very early, rapid increase of enterocyte apoptosis.	2,4-dinitrofluorobenzene sulfonic acid	84-87	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	67-73
17936526-6	2007	Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS.	2,4-dinitrofluorobenzene sulfonic acid	6-10	C-C motif chemokine ligand 27	Homo sapiens	84-89
17936526-6	2007	Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS.	2,4-dinitrofluorobenzene sulfonic acid	6-10	C-C motif chemokine ligand 2	Homo sapiens	84-88
17936526-6	2007	Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS.	2,4-dinitrofluorobenzene sulfonic acid	6-10	C-C motif chemokine receptor 7	Homo sapiens	100-104
17092505-8	2007	Moreover, DNBS-induced colitis in CD4-/- mice (wasting, tissue damage, elevated myeloperoxidase) was not reduced by H. diminuta infection, whereas time-matched infected CD4+ C57Bl/6 mice had significantly less DNBS-induced inflammation.	2,4-dinitrofluorobenzene sulfonic acid	10-14	CD4 antigen	Mus musculus	34-37
17640182-1	2007	A protective role of the transient potential vanilloid receptor 1 (TRPV1) in intestinal inflammation induced by dinitrobenzene sulphonic acid (DNBS) has been recently demonstrated.	2,4-dinitrofluorobenzene sulfonic acid	143-147	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-65
17640182-1	2007	A protective role of the transient potential vanilloid receptor 1 (TRPV1) in intestinal inflammation induced by dinitrobenzene sulphonic acid (DNBS) has been recently demonstrated.	2,4-dinitrofluorobenzene sulfonic acid	143-147	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	67-72
17640182-4	2007	for 2 days before and 5 days after the induction of colitis) was able to reduce DNBS-induced colitis in mice, by acting as a TRPV1 agonist.	2,4-dinitrofluorobenzene sulfonic acid	80-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	125-130
17640182-11	2007	As sensitization of the TRPV1 receptor by mediators of inflammation in damaged tissues has been shown previously, our results suggest that in inflamed, but not in normal tissue, curcumin can interact with the TRPV1 receptor to mediate its protective action in DNBS-induced colitis.	2,4-dinitrofluorobenzene sulfonic acid	260-264	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	24-29
17640182-11	2007	As sensitization of the TRPV1 receptor by mediators of inflammation in damaged tissues has been shown previously, our results suggest that in inflamed, but not in normal tissue, curcumin can interact with the TRPV1 receptor to mediate its protective action in DNBS-induced colitis.	2,4-dinitrofluorobenzene sulfonic acid	260-264	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	209-214
17092505-8	2007	Moreover, DNBS-induced colitis in CD4-/- mice (wasting, tissue damage, elevated myeloperoxidase) was not reduced by H. diminuta infection, whereas time-matched infected CD4+ C57Bl/6 mice had significantly less DNBS-induced inflammation.	2,4-dinitrofluorobenzene sulfonic acid	10-14	myeloperoxidase	Mus musculus	80-95
34812594-3	2022	Herein, we report an organic activatable photosensitizer, CyI-DNBS, bearing 2,4-dinitrobenzenesulfonate (DNBS) as the cage group.	2,4-dinitrofluorobenzene sulfonic acid	105-109	cyclin I	Homo sapiens	58-61
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	2,4-dinitrofluorobenzene sulfonic acid	90-94	interleukin 10	Mus musculus	161-166
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	2,4-dinitrofluorobenzene sulfonic acid	90-94	transforming growth factor, beta 1	Mus musculus	168-176
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	2,4-dinitrofluorobenzene sulfonic acid	90-94	interferon gamma	Mus musculus	182-191
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	2,4-dinitrofluorobenzene sulfonic acid	90-94	interleukin 2	Mus musculus	207-211
10925260-9	2000	Upon stimulation with dendritic cells in the presence of the water-soluble DNFB analogue, DNBS, CTLA-4+ T cells from DNFB-tolerized mice secreted high levels of IL-10, TGF-beta, and IFN-gamma; low levels of IL-2; and no IL-4, resembling the cytokine pattern of T regulatory 1 cells.	2,4-dinitrofluorobenzene sulfonic acid	90-94	interleukin 4	Mus musculus	220-224
17515853-1	2007	The aim of the present study was to examine the role of endogenous peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand on the permeability and structure of small intestine tight junctions (TJs) in an animal model of experimental colitis, induced by dinitrobenzene sulfuric acid (DNBS).	2,4-dinitrofluorobenzene sulfonic acid	296-300	peroxisome proliferator activated receptor alpha	Mus musculus	67-115
17515853-1	2007	The aim of the present study was to examine the role of endogenous peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand on the permeability and structure of small intestine tight junctions (TJs) in an animal model of experimental colitis, induced by dinitrobenzene sulfuric acid (DNBS).	2,4-dinitrofluorobenzene sulfonic acid	296-300	peroxisome proliferator activated receptor alpha	Mus musculus	117-127
16257055-3	2006	The levels at which these proteins are expressed relative to one another, where in the cell they are located and whether they are post-translational modified contributes greatly to the balance in active agonistic to active antagonistic BCL-2 proteins, and this critical balance has been hypothesized to dictate regional astrocytic susceptibility to DNB.	2,4-dinitrofluorobenzene sulfonic acid	349-352	BCL2, apoptosis regulator	Rattus norvegicus	236-241
16257055-4	2006	The effects of DNB on the balance in expression of the BCL-2 family proteins have been evaluated in F344 rat DNB-sensitive (brainstem) and non-sensitive (cortical) tissue homogenates and primary astrocytes.	2,4-dinitrofluorobenzene sulfonic acid	15-18	BCL2, apoptosis regulator	Rattus norvegicus	55-60
16257055-4	2006	The effects of DNB on the balance in expression of the BCL-2 family proteins have been evaluated in F344 rat DNB-sensitive (brainstem) and non-sensitive (cortical) tissue homogenates and primary astrocytes.	2,4-dinitrofluorobenzene sulfonic acid	109-112	BCL2, apoptosis regulator	Rattus norvegicus	55-60
16257055-6	2006	However, moderate increases in BCL-XL are observed only in DNB-treated rat cortical astrocytes, and these increases may be sufficient to shift the constitutive balance in expression of antagonistic to agonistic BCL-2 proteins from a ratio which favors BAX to one in which BAX and BCL-XL are comparably expressed.	2,4-dinitrofluorobenzene sulfonic acid	59-62	Bcl2-like 1	Rattus norvegicus	31-37
16257055-6	2006	However, moderate increases in BCL-XL are observed only in DNB-treated rat cortical astrocytes, and these increases may be sufficient to shift the constitutive balance in expression of antagonistic to agonistic BCL-2 proteins from a ratio which favors BAX to one in which BAX and BCL-XL are comparably expressed.	2,4-dinitrofluorobenzene sulfonic acid	59-62	BCL2, apoptosis regulator	Rattus norvegicus	211-216
16257055-8	2006	BCL-XL overexpression minimizes DNB-induced inhibition of succinate dehydrogenase (complex II) activity and increases significantly the concentration of DNB required to induce MPT onset in primary brainstem and cortical astrocytes.	2,4-dinitrofluorobenzene sulfonic acid	32-35	Bcl2-like 1	Rattus norvegicus	0-6
16257055-8	2006	BCL-XL overexpression minimizes DNB-induced inhibition of succinate dehydrogenase (complex II) activity and increases significantly the concentration of DNB required to induce MPT onset in primary brainstem and cortical astrocytes.	2,4-dinitrofluorobenzene sulfonic acid	153-156	Bcl2-like 1	Rattus norvegicus	0-6
16257055-9	2006	Results from the current investigation suggest that modest region-specific alterations in the balance in expression of antagonistic to agonistic BCL-2 proteins may adequately explain differential regional sensitivity to DNB-induced mitochondrial dysfunction.	2,4-dinitrofluorobenzene sulfonic acid	220-223	BCL2, apoptosis regulator	Rattus norvegicus	145-150
12637253-4	2003	This was accompanied by a reduction in myeloperoxidase activity, and using semiquantitative RT-PCR, an attenuation of the DNB-induced message for IL-1beta was detected.	2,4-dinitrofluorobenzene sulfonic acid	122-125	myeloperoxidase	Mus musculus	39-54
12637253-4	2003	This was accompanied by a reduction in myeloperoxidase activity, and using semiquantitative RT-PCR, an attenuation of the DNB-induced message for IL-1beta was detected.	2,4-dinitrofluorobenzene sulfonic acid	122-125	interleukin 1 beta	Mus musculus	146-154
12637253-5	2003	Western blotting analysis revealed that there was a reproducible DNB-induced activation of p38 MAPK detected in intestinal lysates by using a phosphospecific antibody.	2,4-dinitrofluorobenzene sulfonic acid	65-68	mitogen-activated protein kinase 14	Mus musculus	91-99
11247891-8	2001	Staining of sections of colon obtained from DNBS treated rats with an anti-cyclooxygenase 2 antibody showed diffuse staining of the inflamed tissue.	2,4-dinitrofluorobenzene sulfonic acid	44-48	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	75-91
11247891-9	2001	Furthermore, expression of inducible nitric oxide synthase was found mainly in macrophages located within the inflamed colon of DNBS treated rats.	2,4-dinitrofluorobenzene sulfonic acid	128-132	nitric oxide synthase 2	Rattus norvegicus	27-58
10679082-5	2000	In vitro proliferative responses using spleen cells from DNFB-sensitized and PDT-treated mice showed a significantly lower response to DNBS as compared with cells from DNFB-sensitized mice or DNFB and PDT-treated IL-10-deficient mice.	2,4-dinitrofluorobenzene sulfonic acid	135-139	interleukin 10	Mus musculus	213-218
1825030-3	1991	Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB).	2,4-dinitrofluorobenzene sulfonic acid	141-145	CD8 antigen, alpha chain	Mus musculus	56-60
1825030-16	1991	These results indicate that the Lyt2+ Ts from DNBS-tolerant mice express IL-2 receptors and IL-2 is the lymphokine which induces the Ts to release synthesized SSF.	2,4-dinitrofluorobenzene sulfonic acid	46-50	CD8 antigen, alpha chain	Mus musculus	32-36
1825030-16	1991	These results indicate that the Lyt2+ Ts from DNBS-tolerant mice express IL-2 receptors and IL-2 is the lymphokine which induces the Ts to release synthesized SSF.	2,4-dinitrofluorobenzene sulfonic acid	46-50	interleukin 2	Mus musculus	73-96
34751838-6	2021	CD4+ T cells were injected into DNBS-induced mice through the tail vein.	2,4-dinitrofluorobenzene sulfonic acid	32-36	CD4 antigen	Mus musculus	0-3
34751838-14	2021	Notably, conivaptan markedly alleviated body weight loss, pathological damage, and expression of T-bet and IFN-gamma in the colon of DNBS-treated mice.	2,4-dinitrofluorobenzene sulfonic acid	133-137	T-box 21	Mus musculus	97-102
34751838-14	2021	Notably, conivaptan markedly alleviated body weight loss, pathological damage, and expression of T-bet and IFN-gamma in the colon of DNBS-treated mice.	2,4-dinitrofluorobenzene sulfonic acid	133-137	interferon gamma	Mus musculus	107-116
7165279-7	1982	Contrastingly, if TNBS- and CF3-DNBS-modified splenocytes were injected into either anti-TNBS or anti-CF3-DNBS immunized mice, the modification of radioactivity recovery and L/S indexes (compared to those in non-immunized controls) was always greater in the case of the CF3-DNBS cells.	2,4-dinitrofluorobenzene sulfonic acid	32-36	coagulation factor III	Mus musculus	28-31
35104318-5	2022	ATX was inhibited in vivo in DNBS-induced colitis mice, which were evaluated for colonic inflammation and fibrosis.	2,4-dinitrofluorobenzene sulfonic acid	29-33	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	0-3
35104318-8	2022	An in vivo study indicated that inhibition of ATX was associated with the improvement of morphology and function of diseased MAT, which was combined with ameliorated intestinal inflammation and fibrosis in DNBS-instilled mice.	2,4-dinitrofluorobenzene sulfonic acid	206-210	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	46-49
34609489-4	2022	The advanced l-DNB analysis approach showed that: (i) there was a tipping point before critical transition state during pigmentation process, validated by 3D skin model; (ii) 13 core DNB genes were identified to detect the tipping point as a network biomarker, supported by computational assessment; (iii) core DNB genes such as COL7A1 and CTNNB1 can effectively predict skin lightening, validated by independent human skin data.	2,4-dinitrofluorobenzene sulfonic acid	183-186	collagen type VII alpha 1 chain	Homo sapiens	329-335
34609489-4	2022	The advanced l-DNB analysis approach showed that: (i) there was a tipping point before critical transition state during pigmentation process, validated by 3D skin model; (ii) 13 core DNB genes were identified to detect the tipping point as a network biomarker, supported by computational assessment; (iii) core DNB genes such as COL7A1 and CTNNB1 can effectively predict skin lightening, validated by independent human skin data.	2,4-dinitrofluorobenzene sulfonic acid	183-186	catenin beta 1	Homo sapiens	340-346
2944949-8	1986	The addition of IL 1 to cultures of DNBS-tolerant cells and glutaraldehyde fixed DNP-SC restored the ability of the Ts to release the synthesized factor.	2,4-dinitrofluorobenzene sulfonic acid	36-40	interleukin 1 complex	Mus musculus	16-20
2419406-4	1986	The L3T4+, Lyt-2- dD1.9 T cell clone proliferated in response to DNP-OVA and DNBS, but not TNP-OVA or TNBS, in association with I-Ed determinants present on antigen-presenting cells.	2,4-dinitrofluorobenzene sulfonic acid	77-81	CD8 antigen, alpha chain	Mus musculus	11-16
7165279-7	1982	Contrastingly, if TNBS- and CF3-DNBS-modified splenocytes were injected into either anti-TNBS or anti-CF3-DNBS immunized mice, the modification of radioactivity recovery and L/S indexes (compared to those in non-immunized controls) was always greater in the case of the CF3-DNBS cells.	2,4-dinitrofluorobenzene sulfonic acid	32-36	coagulation factor III	Mus musculus	102-105
7165279-7	1982	Contrastingly, if TNBS- and CF3-DNBS-modified splenocytes were injected into either anti-TNBS or anti-CF3-DNBS immunized mice, the modification of radioactivity recovery and L/S indexes (compared to those in non-immunized controls) was always greater in the case of the CF3-DNBS cells.	2,4-dinitrofluorobenzene sulfonic acid	32-36	coagulation factor III	Mus musculus	102-105
32548267-5	2020	Systemic delivery of hM(IL4) to dinitrobenzene sulphonic acid (DNBS)-treated Rag1-/- mice significantly reduced disease.	2,4-dinitrofluorobenzene sulfonic acid	63-67	interleukin 4	Homo sapiens	21-27
33401615-6	2021	The results show that the DNB controller, although not designed to solve perimeter control problems, successfully prevents congestion from building inside the PN and improves the performance of the entire network.	2,4-dinitrofluorobenzene sulfonic acid	26-29	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	159-161
32548267-5	2020	Systemic delivery of hM(IL4) to dinitrobenzene sulphonic acid (DNBS)-treated Rag1-/- mice significantly reduced disease.	2,4-dinitrofluorobenzene sulfonic acid	63-67	recombination activating 1	Mus musculus	77-81
32095330-0	2020	Homeoprotein OTX1 and OTX2 involvement in rat myenteric neuron adaptation after DNBS-induced colitis.	2,4-dinitrofluorobenzene sulfonic acid	80-84	orthodenticle homeobox 1	Rattus norvegicus	13-17
31483434-4	2019	A new fluorophore bearing two isophorone malononitrile structures was conjugated with DNBS to provide a target probe (CHT), which exhibited a ratiometric sensing behavior towards biothiols.	2,4-dinitrofluorobenzene sulfonic acid	86-90	solute carrier family 5 member 7	Homo sapiens	118-121
32095330-0	2020	Homeoprotein OTX1 and OTX2 involvement in rat myenteric neuron adaptation after DNBS-induced colitis.	2,4-dinitrofluorobenzene sulfonic acid	80-84	orthodenticle homeobox 2	Rattus norvegicus	22-26
32095330-3	2020	In this study, we evaluated OTX1 and OTX2 expression in the rat small intestine and distal colon myenteric plexus after intrarectal dinitro-benzene sulfonic (DNBS) acid-induced colitis.	2,4-dinitrofluorobenzene sulfonic acid	158-162	orthodenticle homeobox 1	Rattus norvegicus	28-32
32095330-3	2020	In this study, we evaluated OTX1 and OTX2 expression in the rat small intestine and distal colon myenteric plexus after intrarectal dinitro-benzene sulfonic (DNBS) acid-induced colitis.	2,4-dinitrofluorobenzene sulfonic acid	158-162	orthodenticle homeobox 2	Rattus norvegicus	37-41
32095330-10	2020	Both in the small intestine and distal colon, the number of OTX1- and OTX2-immunoreactive myenteric neurons significantly increased after DNBS treatment.	2,4-dinitrofluorobenzene sulfonic acid	138-142	orthodenticle homeobox 1	Rattus norvegicus	60-64
32095330-10	2020	Both in the small intestine and distal colon, the number of OTX1- and OTX2-immunoreactive myenteric neurons significantly increased after DNBS treatment.	2,4-dinitrofluorobenzene sulfonic acid	138-142	orthodenticle homeobox 2	Rattus norvegicus	70-74
32095330-12	2020	OTX1 and OTX2 mRNA and protein levels significantly enhanced in LMMP preparations of both regions after DNBS treatment.	2,4-dinitrofluorobenzene sulfonic acid	104-108	orthodenticle homeobox 1	Rattus norvegicus	0-4
32095330-12	2020	OTX1 and OTX2 mRNA and protein levels significantly enhanced in LMMP preparations of both regions after DNBS treatment.	2,4-dinitrofluorobenzene sulfonic acid	104-108	orthodenticle homeobox 2	Rattus norvegicus	9-13