PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11350742-5	2001	We demonstrate here that a clear-cut nuclear redistribution of TonEBP, followed by SMIT expression increase and inositol transport activation, is observed after incubation of cultured human fibroblasts in Earle"s balanced salts (EBSS), an isotonic, amino acid-free saline.	ebss	229-233	nuclear factor of activated T cells 5	Homo sapiens	63-69
11350742-6	2001	EBSS-induced SMIT stimulation is prevented by substrates of system A, although these compounds do not compete with inositol for transport through SMIT.	ebss	0-4	solute carrier family 5 member 3	Homo sapiens	13-17
30992317-8	2019	Furthermore, when reactive oxygen species (ROS) generation was suppressed by antioxidant N-acetyl-l-cysteine (L-NAC) pretreatment, EBSS-induced autophagy was inhibited, and the chloride current was unable to be activated.	ebss	131-135	synuclein alpha	Homo sapiens	112-115
2512264-4	1989	Following 1 h incubation at 37 degrees C in Earle"s balanced salt solution (EBSS) in which females had previously been maintained for 1 h, males showed moderate increase in lipid content and diminished lipase activity.	ebss	76-80	lipase	Schistosoma mansoni	202-208
33186920-8	2020	We found that activation of autophagy could promote MEndT and increase cytoplasmic and total expression of p53, that but nuclear p53 expression was decreased, and that inhibition of autophagy activation could reverse the effect of EBSS.	ebss	231-235	tumor protein p53	Homo sapiens	107-110
33186920-8	2020	We found that activation of autophagy could promote MEndT and increase cytoplasmic and total expression of p53, that but nuclear p53 expression was decreased, and that inhibition of autophagy activation could reverse the effect of EBSS.	ebss	231-235	tumor protein p53	Homo sapiens	129-132
33318468-6	2020	Data from SCC-25 cells demonstrated that rapamycin and Earle"s balanced salt solution (EBSS) promoted autophagy, leading to increased FN1 degradation, while 3-methyladenine (3-MA), bafilomycin A1 (Baf A1) and chloroquine (CQ) inhibited autophagy, leading to decreased FN1 degradation.	ebss	87-91	fibronectin 1	Homo sapiens	134-137
33318468-6	2020	Data from SCC-25 cells demonstrated that rapamycin and Earle"s balanced salt solution (EBSS) promoted autophagy, leading to increased FN1 degradation, while 3-methyladenine (3-MA), bafilomycin A1 (Baf A1) and chloroquine (CQ) inhibited autophagy, leading to decreased FN1 degradation.	ebss	87-91	fibronectin 1	Homo sapiens	268-271
32944332-0	2020	WW and C2 domain-containing protein-3 promoted EBSS-induced apoptosis through inhibiting autophagy in non-small cell lung cancer cells.	ebss	47-51	C2 domain containing 3 centriole elongation regulator	Homo sapiens	7-37
32944332-5	2020	The immunoblotting assay and immunofluorescence assay were performed to detect the impact of WWC3 expression on autophagy process induced by Earle"s balanced salt solution (EBSS) in lung cancer cells; APC/propidium iodide (PI) apoptosis assay, caspase-3/7 activity assay and MTT assay were used for the apoptosis and proliferation detection of lung cancer cells.	ebss	173-177	WWC family member 3	Homo sapiens	93-97
32944332-6	2020	Results: After starvation had been induced with EBSS, WWC3 expression was significantly decreased in the NSCLC cells.	ebss	48-52	WWC family member 3	Homo sapiens	54-58
32944332-7	2020	Ectopic WWC3 expression weakened the autophagy process in a Beclin1-independent manner and promoted non-small cell lung cancer cell apoptosis via EBSS starvation.	ebss	146-150	WWC family member 3	Homo sapiens	8-12
30538566-11	2018	Western blotting indicated that EBSS enhanced the expression of apoptosis-related proteins (cytochrome C, caspase-3, and poly[ADP-ribose] polymerase 1) induced by S1 in HeLa cells.	ebss	32-36	cytochrome c, somatic	Homo sapiens	92-104
30849520-7	2019	Earle"s Balanced Salt Solution (EBSS) decreased the expression of the key focal adhesion protein, paxillin, which was recovered by CRHRs ligands (CRH and UCN2).	ebss	32-36	corticotropin releasing hormone	Homo sapiens	131-134
30849520-7	2019	Earle"s Balanced Salt Solution (EBSS) decreased the expression of the key focal adhesion protein, paxillin, which was recovered by CRHRs ligands (CRH and UCN2).	ebss	32-36	urocortin 2	Homo sapiens	154-158
30646576-10	2019	In addition, SP1 suppressed EBSS-induced conversion of LC3-I to LC3-II and the expression of autophagy-related protein 7.	ebss	28-32	ubiquitin-like modifier-activating enzyme ATG7	Cricetulus griseus	93-120
30538566-11	2018	Western blotting indicated that EBSS enhanced the expression of apoptosis-related proteins (cytochrome C, caspase-3, and poly[ADP-ribose] polymerase 1) induced by S1 in HeLa cells.	ebss	32-36	caspase 3	Homo sapiens	106-115
30538566-11	2018	Western blotting indicated that EBSS enhanced the expression of apoptosis-related proteins (cytochrome C, caspase-3, and poly[ADP-ribose] polymerase 1) induced by S1 in HeLa cells.	ebss	32-36	poly(ADP-ribose) polymerase 1	Homo sapiens	121-150
30151070-4	2018	We first found that EBSS induced an increase in NOX2, NOX4, p22phox, and NOX5 compared to NOX1.	ebss	20-24	cytochrome b-245 beta chain	Homo sapiens	48-52
30151070-4	2018	We first found that EBSS induced an increase in NOX2, NOX4, p22phox, and NOX5 compared to NOX1.	ebss	20-24	NADPH oxidase 4	Homo sapiens	54-58
30151070-4	2018	We first found that EBSS induced an increase in NOX2, NOX4, p22phox, and NOX5 compared to NOX1.	ebss	20-24	cytochrome b-245 alpha chain	Homo sapiens	60-67
30151070-4	2018	We first found that EBSS induced an increase in NOX2, NOX4, p22phox, and NOX5 compared to NOX1.	ebss	20-24	NADPH oxidase 5	Homo sapiens	73-77
30151070-4	2018	We first found that EBSS induced an increase in NOX2, NOX4, p22phox, and NOX5 compared to NOX1.	ebss	20-24	NADPH oxidase 1	Homo sapiens	90-94
29620258-8	2018	The formed autophagic vesicles and increased LC3 II/LC3 I ratio indicated marked induction of autophagy by Earle"s balanced salt solution (EBSS) in Eca-109 cells.	ebss	139-143	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	45-48
29620258-8	2018	The formed autophagic vesicles and increased LC3 II/LC3 I ratio indicated marked induction of autophagy by Earle"s balanced salt solution (EBSS) in Eca-109 cells.	ebss	139-143	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	52-55
29113338-5	2017	We observed discordant expression of XIAP mRNA and protein in the autophagic process induced by EBSS, suggesting XIAP may be regulated at a post-transcriptional level.	ebss	96-100	X-linked inhibitor of apoptosis	Homo sapiens	37-41
29113338-5	2017	We observed discordant expression of XIAP mRNA and protein in the autophagic process induced by EBSS, suggesting XIAP may be regulated at a post-transcriptional level.	ebss	96-100	X-linked inhibitor of apoptosis	Homo sapiens	113-117
28320515-5	2017	Moreover, deprivation of EBSS (Earle"s Balanced Salt Solution) significantly augmented the effect of HMGCS2 on LC3II, while acetoacetate reversed the reduction of LC3II, APP and CTFs which was induced by HMGCS2 knockdown.	ebss	25-29	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	101-107
28450279-7	2017	Cultured mouse podocytes were treated with the autophagy activators, rapamycin or Earle"s balanced salt solution (EBSS), for 48 h. Both rapamycin and EBSS significantly decreased p62 protein levels, increased ERK1/2 activation by phosphorylating pTpY185/187, and increased mRNA and protein expressions of PRR.	ebss	150-154	sequestosome 1	Mus musculus	179-182
28450279-7	2017	Cultured mouse podocytes were treated with the autophagy activators, rapamycin or Earle"s balanced salt solution (EBSS), for 48 h. Both rapamycin and EBSS significantly decreased p62 protein levels, increased ERK1/2 activation by phosphorylating pTpY185/187, and increased mRNA and protein expressions of PRR.	ebss	150-154	mitogen-activated protein kinase 3	Mus musculus	209-215
28450279-7	2017	Cultured mouse podocytes were treated with the autophagy activators, rapamycin or Earle"s balanced salt solution (EBSS), for 48 h. Both rapamycin and EBSS significantly decreased p62 protein levels, increased ERK1/2 activation by phosphorylating pTpY185/187, and increased mRNA and protein expressions of PRR.	ebss	150-154	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	305-308
28450279-8	2017	Utilizing confocal microscopy demonstrated that rapamycin and EBSS significantly decreased p62/SQSTM1 and increased PRR protein expressions.	ebss	62-66	sequestosome 1	Mus musculus	91-94
28450279-8	2017	Utilizing confocal microscopy demonstrated that rapamycin and EBSS significantly decreased p62/SQSTM1 and increased PRR protein expressions.	ebss	62-66	sequestosome 1	Mus musculus	95-101
28450279-8	2017	Utilizing confocal microscopy demonstrated that rapamycin and EBSS significantly decreased p62/SQSTM1 and increased PRR protein expressions.	ebss	62-66	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	116-119
28320515-5	2017	Moreover, deprivation of EBSS (Earle"s Balanced Salt Solution) significantly augmented the effect of HMGCS2 on LC3II, while acetoacetate reversed the reduction of LC3II, APP and CTFs which was induced by HMGCS2 knockdown.	ebss	25-29	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	204-210
20033472-5	2010	Nth1 and a tumor suppressor gene Tuberous sclerosis 2 (Tsc2) are bi-directionally regulated in humans, mice, and rats by a common minimal promoter containing two Ets-binding sites (EBSs).	ebss	181-185	nth like DNA glycosylase 1	Homo sapiens	0-4
27486855-4	2017	We used EBSS treatment with the BH3 domain of Bcl-2 family proteins (BH3) mimetic ABT737, which targets Bcl-2/Bcl-xL, to examine mitochondrial dynamics and the interactive regulatory mechanisms between nutrition and Bcl-2 proteins.	ebss	8-12	BCL2 apoptosis regulator	Homo sapiens	46-51
25212667-6	2015	Compared to initial levels at 0 h, Beclin 1 density in EBSS-treated cells was found to have increased at 6, 12, and 18 h in a time-dependent manner and was found to have subsequently declined at 24 and 48 h. p62 levels, LC3-II/LC3-I ratio, and GFP-LC3 levels increased at 6, 12, 18, 24, and 48 h in a time-dependent manner.	ebss	55-59	beclin 1	Homo sapiens	35-43
25212667-6	2015	Compared to initial levels at 0 h, Beclin 1 density in EBSS-treated cells was found to have increased at 6, 12, and 18 h in a time-dependent manner and was found to have subsequently declined at 24 and 48 h. p62 levels, LC3-II/LC3-I ratio, and GFP-LC3 levels increased at 6, 12, 18, 24, and 48 h in a time-dependent manner.	ebss	55-59	nucleoporin 62	Homo sapiens	208-211
25212667-6	2015	Compared to initial levels at 0 h, Beclin 1 density in EBSS-treated cells was found to have increased at 6, 12, and 18 h in a time-dependent manner and was found to have subsequently declined at 24 and 48 h. p62 levels, LC3-II/LC3-I ratio, and GFP-LC3 levels increased at 6, 12, 18, 24, and 48 h in a time-dependent manner.	ebss	55-59	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	227-230
25212667-6	2015	Compared to initial levels at 0 h, Beclin 1 density in EBSS-treated cells was found to have increased at 6, 12, and 18 h in a time-dependent manner and was found to have subsequently declined at 24 and 48 h. p62 levels, LC3-II/LC3-I ratio, and GFP-LC3 levels increased at 6, 12, 18, 24, and 48 h in a time-dependent manner.	ebss	55-59	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	227-230
23433111-5	2013	We found that three Egr-1-binding sequences (EBSs) were located at -1031, -1005, and -385 within the enhancer region of the BRCA1 gene.	ebss	45-49	early growth response 1	Homo sapiens	20-25
23433111-5	2013	We found that three Egr-1-binding sequences (EBSs) were located at -1031, -1005, and -385 within the enhancer region of the BRCA1 gene.	ebss	45-49	BRCA1 DNA repair associated	Homo sapiens	124-129
22803432-11	2012	RESULTS: Two h after culture, when compared with the EBSS + vehicle serum group, GFP-LC3B changing from diffused distribution to dotted distribution was obviously inhibited in the EBSS +5 times LR serum group and the EBSS +10 times LR serum group (P<0.01).	ebss	53-57	microtubule associated protein 1 light chain 3 beta	Homo sapiens	85-89
22803432-11	2012	RESULTS: Two h after culture, when compared with the EBSS + vehicle serum group, GFP-LC3B changing from diffused distribution to dotted distribution was obviously inhibited in the EBSS +5 times LR serum group and the EBSS +10 times LR serum group (P<0.01).	ebss	180-184	microtubule associated protein 1 light chain 3 beta	Homo sapiens	85-89
22803432-11	2012	RESULTS: Two h after culture, when compared with the EBSS + vehicle serum group, GFP-LC3B changing from diffused distribution to dotted distribution was obviously inhibited in the EBSS +5 times LR serum group and the EBSS +10 times LR serum group (P<0.01).	ebss	180-184	microtubule associated protein 1 light chain 3 beta	Homo sapiens	85-89
25944097-13	2015	Secondly, DNA damage in Klf4-null MEFs increased after treatment with EBSS and was correlated with increased apoptosis.	ebss	70-74	Kruppel-like factor 4 (gut)	Mus musculus	24-28
25062457-4	2014	OBJECTIVE: The current study aimed to investigate the potential involvement of BAG3 in canonical autophagy triggered by Earle"s Balanced Salt Solution (EBSS) starvation.	ebss	152-156	BAG cochaperone 3	Homo sapiens	79-83
25062457-9	2014	RESULTS: BAG3 expression was potently reduced by EBSS starvation.	ebss	49-53	BAG cochaperone 3	Homo sapiens	9-13
20033472-5	2010	Nth1 and a tumor suppressor gene Tuberous sclerosis 2 (Tsc2) are bi-directionally regulated in humans, mice, and rats by a common minimal promoter containing two Ets-binding sites (EBSs).	ebss	181-185	TSC complex subunit 2	Homo sapiens	33-53
20033472-5	2010	Nth1 and a tumor suppressor gene Tuberous sclerosis 2 (Tsc2) are bi-directionally regulated in humans, mice, and rats by a common minimal promoter containing two Ets-binding sites (EBSs).	ebss	181-185	TSC complex subunit 2	Homo sapiens	55-59
20033472-8	2010	This reduction in the mRNA levels was due to the reduced binding of EBSs in the Nth1/Tsc2 promoter.	ebss	68-72	nth-like DNA glycosylase 1	Rattus norvegicus	80-84
20033472-8	2010	This reduction in the mRNA levels was due to the reduced binding of EBSs in the Nth1/Tsc2 promoter.	ebss	68-72	TSC complex subunit 2	Rattus norvegicus	85-89
19247449-4	2009	We showed that EFT-specific EWS/ETS fusion proteins enhance the DKK2 promoter activity, but not DKK1 promoter activity, via ets binding sites (EBSs) in the 5" upstream region.	ebss	143-147	EWS RNA binding protein 1	Homo sapiens	28-31
19935876-4	2009	The ICAM-1 promoter contains several cis-active regulatory elements including 2 Ets binding sites (EBSs) located at positions -158 and -138 relatively to the AUG, which were previously shown to play a role in the constitutive activity of the ICAM-1 promoter.	ebss	99-103	intercellular adhesion molecule 1	Homo sapiens	4-10
19935876-4	2009	The ICAM-1 promoter contains several cis-active regulatory elements including 2 Ets binding sites (EBSs) located at positions -158 and -138 relatively to the AUG, which were previously shown to play a role in the constitutive activity of the ICAM-1 promoter.	ebss	99-103	intercellular adhesion molecule 1	Homo sapiens	242-248
19935876-5	2009	In the present study, we have determined whether the EBSs are also involved in the regulation of ICAM-1 gene transcription by pro-inflammatory cytokines.	ebss	53-57	intercellular adhesion molecule 1	Homo sapiens	97-103
19935876-8	2009	Stimulation of the transcriptional activity following IFN-gamma treatment was significantly reduced when both EBSs were inactivated.	ebss	110-114	interferon gamma	Homo sapiens	54-63
19247449-5	2009	EWS/ETS-mediated transactivation of the promoter was suppressed by the deletion and mutation of EBSs located upstream of the DKK2 gene.	ebss	96-100	EWS RNA binding protein 1	Homo sapiens	0-3
19247449-5	2009	EWS/ETS-mediated transactivation of the promoter was suppressed by the deletion and mutation of EBSs located upstream of the DKK2 gene.	ebss	96-100	dickkopf WNT signaling pathway inhibitor 2	Homo sapiens	125-129
16310515-2	2005	We investigated the role of the putative Ets-binding sites (EBSs) in the transactivation of the proximal promoter of rat heme oxygenase 1 (hmox1) gene by the Ets oncoproteins Fli-1, Erg-2, and Ets-1 in mesangial cells.	ebss	60-64	heme oxygenase 1	Rattus norvegicus	121-137
16310515-2	2005	We investigated the role of the putative Ets-binding sites (EBSs) in the transactivation of the proximal promoter of rat heme oxygenase 1 (hmox1) gene by the Ets oncoproteins Fli-1, Erg-2, and Ets-1 in mesangial cells.	ebss	60-64	heme oxygenase 1	Rattus norvegicus	139-144
16310515-2	2005	We investigated the role of the putative Ets-binding sites (EBSs) in the transactivation of the proximal promoter of rat heme oxygenase 1 (hmox1) gene by the Ets oncoproteins Fli-1, Erg-2, and Ets-1 in mesangial cells.	ebss	60-64	Fli-1 proto-oncogene, ETS transcription factor	Rattus norvegicus	175-180
16310515-2	2005	We investigated the role of the putative Ets-binding sites (EBSs) in the transactivation of the proximal promoter of rat heme oxygenase 1 (hmox1) gene by the Ets oncoproteins Fli-1, Erg-2, and Ets-1 in mesangial cells.	ebss	60-64	potassium voltage-gated channel subfamily H member 6	Rattus norvegicus	182-187
12543860-3	2003	The basal promoter activity of FR-beta resulted from synergistic interaction between Sp1 and ets binding sites (EBSs) and repression by upstream AP-1-like elements, whose action required EBSs.	ebss	112-116	folate receptor beta	Homo sapiens	31-38
12543860-3	2003	The basal promoter activity of FR-beta resulted from synergistic interaction between Sp1 and ets binding sites (EBSs) and repression by upstream AP-1-like elements, whose action required EBSs.	ebss	187-191	folate receptor beta	Homo sapiens	31-38
15003510-5	2004	Sequential deletion of EBSs and mutation analysis revealed that EBS8 located at -416/-406 from the translation initiation site was critical for Ets-1- or Ets-2-stimulated promoter activity.	ebss	23-27	ETS proto-oncogene 1, transcription factor	Homo sapiens	144-149
15003510-5	2004	Sequential deletion of EBSs and mutation analysis revealed that EBS8 located at -416/-406 from the translation initiation site was critical for Ets-1- or Ets-2-stimulated promoter activity.	ebss	23-27	ETS proto-oncogene 2, transcription factor	Homo sapiens	154-159