PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2553745-3	1989	The activity of PKN was inhibited in vitro by purine analogues, the most effective of which was 6-thioguanine (apparent Ki = 6 microM).	Thioguanine	96-109	protein kinase N1	Rattus norvegicus	16-19
2627161-2	1989	Non-adherent cells reconstituted with Tg-pulsed autologous adherent cells at the ratio of 9:1 also acquired IL2 responsiveness, but those cultured with OVA (ovalbumin)-pulse adherent cells did not.	Thioguanine	38-40	interleukin 2	Homo sapiens	108-111
2553745-4	1989	Several different criteria indicated that 6-thioguanine is not a general inhibitor of protein kinases and that it is relatively specific for PKN.	Thioguanine	42-55	protein kinase N1	Rattus norvegicus	141-144
2553745-10	1989	Thus, purine analogues such as 6-thioguanine appear capable of differentially suppressing some, but not other actions of NGF.	Thioguanine	31-44	nerve growth factor	Rattus norvegicus	121-124
2788855-2	1989	The damage of this locus leads to the loss of the sensitivity of the T-lymphocytes to 6-thioguanine (TG) therefore in the presence of this antimetabolite (TG) the cells will respond to the lectin"s (phytohaemagglitinine: PHA) growth stimulatory effect.	Thioguanine	86-99	lamin B receptor	Homo sapiens	221-224
2513475-6	1989	A recessive mutant, selected in 6-thioguanine plus IFN, was completely resistant to IFN-alpha but responded normally to IFN-gamma and, unexpectedly, partially to IFN-beta.	Thioguanine	32-45	interferon alpha 1	Homo sapiens	84-93
2513475-6	1989	A recessive mutant, selected in 6-thioguanine plus IFN, was completely resistant to IFN-alpha but responded normally to IFN-gamma and, unexpectedly, partially to IFN-beta.	Thioguanine	32-45	interferon gamma	Homo sapiens	120-129
2513475-6	1989	A recessive mutant, selected in 6-thioguanine plus IFN, was completely resistant to IFN-alpha but responded normally to IFN-gamma and, unexpectedly, partially to IFN-beta.	Thioguanine	32-45	interferon beta 1	Homo sapiens	162-170
2685319-3	1989	The cells were irradiated with ultraviolet light and gpt- colonies were selected by resistance to 6-thioguanine.	Thioguanine	98-111	alanine aminotransferase 1	Cricetulus griseus	53-56
2743331-7	1989	However, when the NK cells were pretreated with 100 IU/ml IFN-alpha followed by 10 microM 6-TG, the IFN-alpha-enhanced activity of NK cells was ablated.	Thioguanine	90-94	interferon alpha 1	Homo sapiens	100-109
2790019-4	1989	The difference in hydration free energies between the Z and the B conformations (delta delta GH(Z-B] was determined from these surfaces to be -0.494 kcal/mol for C-5 methylated d(CG), 0.228 kcal/mol for unmethylated d(CG), 0.756 kcal/mol for d(CA)-d(TG), and 0.896 kcal/mol for d(TA) dinucleotides.	Thioguanine	250-252	complement C5	Homo sapiens	162-165
2790019-5	1989	These delta delta GH(Z-B) values were compared to the experimental B- to Z-DNA transition energies of -0.56 kcal/mol that we measured for C-5 methylated d(CG), 0.69-1.30 kcal/mol reported for unmethylated d(CG), 1.32-1.48 kcal/mol reported for d(CA)-d(TG), and 2.3-2.4 kcal/mol for d(TA) dinucleotides.	Thioguanine	252-254	complement C5	Homo sapiens	138-141
2743319-3	1989	Subpopulation 44FTO is a variant selected for resistance to 6-thioguanine and to ouabain.	Thioguanine	60-73	fat mass and obesity associated	Mus musculus	16-19
2614276-7	1989	Apolipoprotein B-40 (Val1829----Cys-TERM) is the result of a dinucleotide (TG) deletion in exon 26 that generates a stop codon at position 1830 and produces a protein with a predicted molecular mass of 207.14 kDa.	Thioguanine	75-77	apolipoprotein B	Homo sapiens	0-16
2788855-2	1989	The damage of this locus leads to the loss of the sensitivity of the T-lymphocytes to 6-thioguanine (TG) therefore in the presence of this antimetabolite (TG) the cells will respond to the lectin"s (phytohaemagglitinine: PHA) growth stimulatory effect.	Thioguanine	101-103	lamin B receptor	Homo sapiens	221-224
2788855-2	1989	The damage of this locus leads to the loss of the sensitivity of the T-lymphocytes to 6-thioguanine (TG) therefore in the presence of this antimetabolite (TG) the cells will respond to the lectin"s (phytohaemagglitinine: PHA) growth stimulatory effect.	Thioguanine	155-157	lamin B receptor	Homo sapiens	221-224
2474861-3	1989	Subcloning of 6-thioguanine-resistant (6TG") isolates resulted in clones without detectable HPRT activity.	Thioguanine	14-27	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	92-96
2762303-4	1989	We report here the biochemical and molecular characterization of spontaneous mutations at the X chromosome-linked hypoxanthine phosphoribosyltransferase (HPRT) locus in 6-thioguanine-resistant WS and control cells.	Thioguanine	169-182	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	114-152
2762303-4	1989	We report here the biochemical and molecular characterization of spontaneous mutations at the X chromosome-linked hypoxanthine phosphoribosyltransferase (HPRT) locus in 6-thioguanine-resistant WS and control cells.	Thioguanine	169-182	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	154-158
2646261-8	1989	Mutation frequency was determined at the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus using resistance to 6-thioguanine (6-TG).	Thioguanine	122-135	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	41-87
2783475-1	1989	In vivo mutations at the locus for hypoxanthine phosphoribosyl transferase (hprt) were studied in 6-thioguanine (TG)-resistant T-lymphocyte clones from healthy male and female subjects and ovarian carcinoma patients treated with melphalan.	Thioguanine	98-111	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	35-74
2783475-1	1989	In vivo mutations at the locus for hypoxanthine phosphoribosyl transferase (hprt) were studied in 6-thioguanine (TG)-resistant T-lymphocyte clones from healthy male and female subjects and ovarian carcinoma patients treated with melphalan.	Thioguanine	98-111	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	76-80
2783475-1	1989	In vivo mutations at the locus for hypoxanthine phosphoribosyl transferase (hprt) were studied in 6-thioguanine (TG)-resistant T-lymphocyte clones from healthy male and female subjects and ovarian carcinoma patients treated with melphalan.	Thioguanine	113-115	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	35-74
2783475-1	1989	In vivo mutations at the locus for hypoxanthine phosphoribosyl transferase (hprt) were studied in 6-thioguanine (TG)-resistant T-lymphocyte clones from healthy male and female subjects and ovarian carcinoma patients treated with melphalan.	Thioguanine	113-115	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	76-80
2908855-0	1989	Molecular analysis of spontaneous hypoxanthine phosphoribosyltransferase mutations in thioguanine-resistant HL-60 human leukemia cells.	Thioguanine	86-97	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	34-72
2908855-1	1989	We have measured the forward mutation rate at the hypoxanthine phosphoribosyltransferase (HPRT) gene of the human promyelocytic leukemia cell line HL-60 and have determined the molecular spectrum of spontaneous HPRT mutations in 45 independent 6-thioguanine-resistant HL-60 sublines.	Thioguanine	244-257	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	211-215
2908855-3	1989	Blot hybridization analysis of the X-linked HPRT gene using a human HPRT complementary DNA probe revealed abnormalities in HPRT gene structure and/or HPRT mRNA expression in 24 of 45 (53%) independent thioguanine-resistant HL-60 sublines.	Thioguanine	201-212	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	44-48
2908855-3	1989	Blot hybridization analysis of the X-linked HPRT gene using a human HPRT complementary DNA probe revealed abnormalities in HPRT gene structure and/or HPRT mRNA expression in 24 of 45 (53%) independent thioguanine-resistant HL-60 sublines.	Thioguanine	201-212	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	68-72
2908855-3	1989	Blot hybridization analysis of the X-linked HPRT gene using a human HPRT complementary DNA probe revealed abnormalities in HPRT gene structure and/or HPRT mRNA expression in 24 of 45 (53%) independent thioguanine-resistant HL-60 sublines.	Thioguanine	201-212	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	68-72
2908855-3	1989	Blot hybridization analysis of the X-linked HPRT gene using a human HPRT complementary DNA probe revealed abnormalities in HPRT gene structure and/or HPRT mRNA expression in 24 of 45 (53%) independent thioguanine-resistant HL-60 sublines.	Thioguanine	201-212	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	68-72
3050492-4	1988	These cells with a genotype of hgprt-/Ecogpt+ can grow in medium containing mycophenolic acid and xanthine (MX medium) but not in medium containing 6-thioguanine (6-TG).	Thioguanine	148-161	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	31-36
3050492-5	1988	The loss of the human chromosome from R3-5 cells as a result of chemical treatment produces cells with a genotype of hgprt-/Ecogpt- which are capable of growth in the medium containing 6-TG.	Thioguanine	185-189	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	117-122
3173402-3	1988	Mutation analysis at the HGPRT locus also indicates the increased sensitivity of UV-5 cells to N-OH-AAF as witnessed by an enhanced induction of 6-thioguanine-resistant colonies at equitoxic doses.	Thioguanine	145-158	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	25-30
2733715-6	1989	Mutations at the HPRT locus were measured by determining the 6-thioguanine-resistant mutant fraction.	Thioguanine	61-74	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-21
2471066-2	1989	Mutants deficient in HPRT were first selected by growth in 6-thioguanine from two primary fibroblast cell lines and from transformed lines derived from them.	Thioguanine	59-72	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	21-25
2494446-1	1989	AS52 cells are Chinese hamster ovary (CHO) cells that carry a single functional copy of the bacterial gpt gene and allow the isolation of 6-thioguanine-resistant (6TGr)mutants arising from mutation at the chromosally integrated gpt locus.	Thioguanine	138-151	alanine aminotransferase 1	Cricetulus griseus	102-105
2645514-4	1989	The 6-thioguanine (6TG) exposure conditions which inhibited DNA synthesis, as measured by BrUdR incorporation, in wild-type cells while allowing proliferation of spontaneous hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutants were investigated using tumour cell lines.	Thioguanine	4-17	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	222-226
2645514-4	1989	The 6-thioguanine (6TG) exposure conditions which inhibited DNA synthesis, as measured by BrUdR incorporation, in wild-type cells while allowing proliferation of spontaneous hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutants were investigated using tumour cell lines.	Thioguanine	19-22	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	222-226
2598410-3	1989	The guanine analogs, 6-thioguanine and 8-azaguanine, induce granulocytic differentiation of HGPRT-deficient HL-60 promyelocytes.	Thioguanine	21-34	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	92-97
2570674-8	1989	The specific activity of triglyceride TG-SRA found in the tissues was also the same in control and experimental birds.	Thioguanine	38-40	steroid receptor RNA activator 1	Homo sapiens	41-44
2570674-9	1989	The time-course of the changes in plasma TG-SRA throughout the experimental period gave no indication that TG production had been affected by exercise.	Thioguanine	41-43	steroid receptor RNA activator 1	Homo sapiens	44-47
3167854-4	1988	The human leukemic cell line, CCRF-CEM, was used to investigate the conditions necessary for the stringent selection of HPRT- mutants using 6-thioguanine (6TG).	Thioguanine	140-153	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	120-124
3167854-5	1988	The appropriate 6TG exposure necessary to inhibit BrdUrd incorporation in wild-type cells, while allowing proliferation of spontaneous HPRT- mutants, was greater than or equal to 30 microM 6TG for 72 h (10 microM BrdUrd added 24 h prior to harvest).	Thioguanine	16-19	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	135-139
2903442-1	1988	The molecular nature of mutations in 6-thioguanine-resistant hypoxanthine/guanine phosphoribosyl transferase (HGPRT)-deficient clones of an adult rat liver (ARL) epithelial cell line mutated by benzo[a]pyrene or aflatoxin B1 was studied.	Thioguanine	37-50	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	61-108
2903442-1	1988	The molecular nature of mutations in 6-thioguanine-resistant hypoxanthine/guanine phosphoribosyl transferase (HGPRT)-deficient clones of an adult rat liver (ARL) epithelial cell line mutated by benzo[a]pyrene or aflatoxin B1 was studied.	Thioguanine	37-50	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	110-115
2646261-8	1989	Mutation frequency was determined at the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus using resistance to 6-thioguanine (6-TG).	Thioguanine	122-135	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	89-94
2646261-8	1989	Mutation frequency was determined at the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus using resistance to 6-thioguanine (6-TG).	Thioguanine	137-141	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	41-87
2646261-8	1989	Mutation frequency was determined at the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus using resistance to 6-thioguanine (6-TG).	Thioguanine	137-141	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	89-94
2825968-7	1988	Furthermore, an HL-60 subline deficient in hypoxanthine-guanine phosphoribosyltransferase, which differentiates in the presence of 6-thioguanine, produced a decrease in phosphotyrosine residues and increases in tyrosine kinase and phosphotyrosine phosphatase activities in response to the purine antimetabolite, while the parental HL-60 line, in which 6-thioguanine inhibits cellular proliferation but does not induce maturation, does not exhibit these changes.	Thioguanine	131-144	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	43-89
3396300-16	1988	Addition of the xanthine oxidase inhibitor oxypurinol at a luminal concentration of 0.3 mmol/l prevented the formation of 6-thiouric acid from 6-thioguanine.	Thioguanine	143-156	xanthine dehydrogenase	Mus musculus	16-32
2834046-8	1988	An HL-60 variant that had been selected for resistance to TG-induced growth inhibition and differentiation (R. E. Gallagher et al., Cancer Res., 44: 2642-2653, 1984) was found to have less than 20% of the cell surface GM-CSF receptors when compared to either wild type cells, or a variant line selected for resistance to TG cytotoxicity.	Thioguanine	58-60	colony stimulating factor 2	Homo sapiens	218-224
2825968-7	1988	Furthermore, an HL-60 subline deficient in hypoxanthine-guanine phosphoribosyltransferase, which differentiates in the presence of 6-thioguanine, produced a decrease in phosphotyrosine residues and increases in tyrosine kinase and phosphotyrosine phosphatase activities in response to the purine antimetabolite, while the parental HL-60 line, in which 6-thioguanine inhibits cellular proliferation but does not induce maturation, does not exhibit these changes.	Thioguanine	352-365	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	43-89
3310264-3	1987	Following mutagenesis by EtMes, cells with mutations in the gpt gene were selected as resistant to 6-thioguanine.	Thioguanine	99-112	glutamic pyruvic transaminase, soluble	Mus musculus	60-63
3479681-1	1987	Treatment of hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-deficient human promyelocytic leukemia (HL-60) cells with 6-thioguanine results in growth inhibition and cell differentiation.	Thioguanine	126-139	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	13-59
3479681-1	1987	Treatment of hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-deficient human promyelocytic leukemia (HL-60) cells with 6-thioguanine results in growth inhibition and cell differentiation.	Thioguanine	126-139	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	61-66
3479681-3	1987	During the early stages of HGPRT-deficient HL-60 cell differentiation induced by 6-thioguanine, there was a transient decrease in the queuine content of tRNA, and changes in the isoacceptor profiles of tRNA(His) indicate that 6-thioguanine was incorporated into the tRNA in place of queuine.	Thioguanine	81-94	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	27-32
3479681-3	1987	During the early stages of HGPRT-deficient HL-60 cell differentiation induced by 6-thioguanine, there was a transient decrease in the queuine content of tRNA, and changes in the isoacceptor profiles of tRNA(His) indicate that 6-thioguanine was incorporated into the tRNA in place of queuine.	Thioguanine	226-239	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	27-32
3627157-1	1987	The autoradiographic assay developed by Strauss and Albertini (1979) to quantitate human in vivo somatic mutation at the hypoxanthine guanine phosphoribosyl-transferase locus uses tritiated thymidine to identify mutant cells by their ability to pass through "S" phase in the presence of 6-thioguanine.	Thioguanine	287-300	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	121-168
3595540-1	1987	[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes.	Thioguanine	28-30	thyroglobulin	Homo sapiens	6-19
3595540-1	1987	[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes.	Thioguanine	89-91	thyroglobulin	Homo sapiens	6-19
3497342-1	1987	The measurement of 6-thioguanine-resistant frequencies in human T-lymphocytes has been used to quantitate the in vivo HPRT mutant frequency.	Thioguanine	19-32	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	118-122
3554239-3	1987	Cells with spontaneous mutations in the gpt gene were selected as resistant to 6-thioguanine and then were fused with COS cells for recovery of the mutant genes.	Thioguanine	79-92	glutamic--pyruvic transaminase	Homo sapiens	40-43
3308570-5	1987	In the case of endogenous hyperinsulinism, there is an intrahepatic disturbance of HDL metabolism partly related to excessive synthesis of VLDL-TG and leading to the decrease of HDL2/HDL3 and enhanced formation of HDL2 TG.	Thioguanine	219-221	junctophilin 3	Homo sapiens	214-218
3476817-1	1987	The feasibility of using retroviral gene therapy to overcome drug resistance was assessed by determining the efficiency by which a retrovirus containing the human HGPRT gene could sensitize hypoxanthine-guanine phosphoribosyltransferase (HGPRT) negative human promyelocytic leukemia cells to 6-thioguanine.	Thioguanine	292-305	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	163-168
3658932-4	1987	Elevated levels of TG, TSH, PTH, T4 and a lowered level of CT were revealed in differentiated thyroid carcinomas; elevated levels of CT, TSH, PTH, T4 and a lowered level of TG were revealed in medullary carcinoma.	Thioguanine	173-175	calcitonin related polypeptide alpha	Homo sapiens	59-61
3554239-4	1987	Out of a total of 77 independent 6-thioguanine-resistant cell lines isolated in this study, vector sequences could be rescued from 43 of the mutant lines, and the base sequences were determined for the gpt genes in all 43 of these lines.	Thioguanine	33-46	glutamic--pyruvic transaminase	Homo sapiens	202-205
3622386-1	1987	Combination of two thyroglobulin monoclonal antibodies (monoAbs) recognizing epitopes which are rarely recognized by an antibody enabled us to develop a rapid one-step enzyme immunoassay of serum Tg.	Thioguanine	196-198	thyroglobulin	Equus caballus	19-32
3550445-5	1987	Furthermore, exposure of V79 cells co-cultured with PCB-pretreated hepatocytes to IQ and MeIQ showed evidence of increased sister-chromatid exchanges and a low and variable increase in the number of 6-thioguanine-resistant mutants.	Thioguanine	199-212	pyruvate carboxylase	Rattus norvegicus	52-55
3297132-1	1987	An N-glycosylase activity that released cis-[3H]-5,6-dihydroxy-5,6-dihydrothymine (thymine glycol, TG) from chemically oxidized poly(dA-[3H]dT) was unambiguously characterized both in extracts of HeLa cells and in purified Escherichia coli endonuclease III.	Thioguanine	99-101	endonuclease III	Escherichia coli	240-256
3466691-2	1987	Mutations at the hypoxanthine-guanine phosphoribosyltransferase locus were studied by enumerating thioguanine-resistant cells in a clonogenic assay.	Thioguanine	98-109	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-63
3469509-9	1987	In the former category, cells which became HPRT- (6-thioguanine resistant [6TGr]) also became G418s, indicative of a cis-acting down regulation of expression.	Thioguanine	50-63	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	43-47
3469621-3	1987	NIH3T3 cells can be mutated to 6-thioguanine resistance at a frequency which suggests that at least a portion of the cells have only one functional copy of the HGPRT gene.	Thioguanine	31-44	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	160-165
3567721-10	1987	The highly significant relationship between enzyme activity and TG content support our working hypothesis that the intracellular TG lipase (LPL) is playing a role in regulating cardiac TG content.	Thioguanine	64-66	lipoprotein lipase	Rattus norvegicus	140-143
2943802-4	1986	We find that, like most Lyt-1+, 2- T cells, the THg cells can be eliminated by monoclonal anti-L3T4 antibody and complement treatment, whereas such treatment had no effect on adoptive transfer of SRBC-immune THd cell activity.	Thioguanine	48-51	CD5 antigen	Mus musculus	24-29
2821020-6	1987	Three out of four thioguanine-resistant derivatives of clone 67 have either lost or do not express the gpt sequence and show almost the same sensitivity to gamma irradiation as the original AT5BIVA line.	Thioguanine	18-29	glutamic--pyruvic transaminase	Homo sapiens	103-106
3796669-1	1987	We used the V79 Chinese hamster cell line to detect the induction by NTA of 6-thioguanine resistance, due to mutation at the HGPRT locus, with direct and indirect mutagens as positive controls.	Thioguanine	76-89	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	125-130
3779323-1	1986	Cells with mutations at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus may be detected in vitro by their resistance to the toxic effects of thioguanine.	Thioguanine	158-169	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	28-75
3779323-1	1986	Cells with mutations at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus may be detected in vitro by their resistance to the toxic effects of thioguanine.	Thioguanine	158-169	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	77-81
3778494-2	1986	Both assays required one of the test cell pair to be resistant both to ouabain and to thioguanine (deficient in hypoxanthine-guanine phosphoribosyltransferase).	Thioguanine	86-97	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	112-158
2429561-9	1986	The results are interpreted to indicate that TG (or gastrin) stimulates H+ secretion through different mechanisms: 1) direct stimulation of the oxyntic cell dependent on extracellular calcium, 2) potentiation between gastrin and histamine, and 3) release of histamine from paracrine cells.	Thioguanine	45-47	gastrin	Homo sapiens	217-224
2943802-5	1986	Similarly, THg cell activity was eliminated from SRBC-immune T cells by treatment with monoclonal anti-T cell receptor beta-chain allotope antibody plus anti-rat IgG and complement, whereas THd cell activity remained intact.	Thioguanine	11-14	T cell receptor beta chain	Mus musculus	103-129
3731106-2	1986	Unsaturated free fatty acids (oleate, linoleate, linolenate, palmitoleate, myristoleate, and arachidonate) inhibited metabolic cooperation between 6-thioguanine-resistant, hypoxanthine guanine phosphoribosyltransferase-deficient and 6-thioguanine-sensitive, hypoxanthine guanine phosphoribosyltransferase-proficient V79 cells.	Thioguanine	233-246	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	172-218
3758918-9	1986	The reverse mutation frequency rate at the HGPRT locus in 5 macrophage-induced variants was low and similar to that of a stable, ethyl methanesulfonate-induced thioguanine resistant line, suggesting that macrophage induction of thioguanine resistance was the result of a true mutation, rather than an epigenetic event.	Thioguanine	228-239	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	43-48
3010099-1	1986	The restriction endonuclease Alu I induces chromosomal aberrations and mutations in the hypoxanthine phosphoribosyltransferase (HPRT) locus as measured by 6-thioguanine resistance (TGr) in V79 hamster cells.	Thioguanine	155-168	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	88-126
3084067-1	1986	The ability of macrophages to induce drug-resistant variants was studied in an in vitro macrophage-tumor cell coculture system utilizing the hypoxanthine-guanine phosphoribosyl transferase locus as measured by resistance to 6-thioguanine.	Thioguanine	224-237	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	141-188
3084067-8	1986	The reverse variation frequency at the hypoxanthine-guanine phosphoribosyl transferase locus in five macrophage-induced variants was low and similar to that of a stable ethyl methanesulfonate-induced, thioguanine-resistant line.	Thioguanine	201-212	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	39-86
3010099-1	1986	The restriction endonuclease Alu I induces chromosomal aberrations and mutations in the hypoxanthine phosphoribosyltransferase (HPRT) locus as measured by 6-thioguanine resistance (TGr) in V79 hamster cells.	Thioguanine	155-168	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	128-132
4062957-1	1985	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic thiol compounds including drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine.	Thioguanine	161-174	thiopurine methyltransferase	Mus musculus	0-28
3751447-2	1986	Stable HbA1 and 24-h mean blood glucose, but not daily insulin dosage, were positively correlated to VLDL-TG (p less than 0.001) and negatively correlated to HDL2-C (p less than 0.05).	Thioguanine	106-108	hemoglobin subunit alpha 1	Homo sapiens	7-11
3005850-4	1986	As with CHO-K1-BH4 HPRT mutants, spontaneous or induced XPRT mutants derived from the gpt+ cell lines can be selected for 6-thioguanine resistance (TGr).	Thioguanine	122-135	alanine aminotransferase 1	Cricetulus griseus	86-89
3943100-3	1986	The assay was based on the metabolic isolation of hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-deficient variants in the presence of HGPRT-proficient cells and 6-thioguanine.	Thioguanine	170-183	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	50-96
3943100-4	1986	Chemicals which inhibit the transfer of the lethal metabolite of 6-thioguanine from HGPRT-proficient to HGPRT-deficient cells will allow for recovery of the 6-thioguanine-resistant (HGPRT-deficient) cells.	Thioguanine	65-78	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	84-89
3943100-4	1986	Chemicals which inhibit the transfer of the lethal metabolite of 6-thioguanine from HGPRT-proficient to HGPRT-deficient cells will allow for recovery of the 6-thioguanine-resistant (HGPRT-deficient) cells.	Thioguanine	65-78	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	104-109
3943100-4	1986	Chemicals which inhibit the transfer of the lethal metabolite of 6-thioguanine from HGPRT-proficient to HGPRT-deficient cells will allow for recovery of the 6-thioguanine-resistant (HGPRT-deficient) cells.	Thioguanine	65-78	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	104-109
3943100-4	1986	Chemicals which inhibit the transfer of the lethal metabolite of 6-thioguanine from HGPRT-proficient to HGPRT-deficient cells will allow for recovery of the 6-thioguanine-resistant (HGPRT-deficient) cells.	Thioguanine	157-170	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	84-89
3943100-4	1986	Chemicals which inhibit the transfer of the lethal metabolite of 6-thioguanine from HGPRT-proficient to HGPRT-deficient cells will allow for recovery of the 6-thioguanine-resistant (HGPRT-deficient) cells.	Thioguanine	157-170	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	104-109
3943100-4	1986	Chemicals which inhibit the transfer of the lethal metabolite of 6-thioguanine from HGPRT-proficient to HGPRT-deficient cells will allow for recovery of the 6-thioguanine-resistant (HGPRT-deficient) cells.	Thioguanine	157-170	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	104-109
4064256-4	1985	At every dose the frequency of 6-thioguanine resistant cells induced by MNNG was higher in the MT-depleted populations than in the controls.	Thioguanine	31-44	O-6-methylguanine-DNA methyltransferase	Homo sapiens	95-97
4053002-2	1985	Mutations at the hypoxanthine:guanine phosphoribosyltransferase locus and the Na/K ATPase locus were scored by resistance to 6-thioguanine and ouabain, respectively.	Thioguanine	125-138	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	17-63
4062957-1	1985	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic thiol compounds including drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine.	Thioguanine	161-174	thiopurine methyltransferase	Mus musculus	30-34
3161610-7	1985	After an expression period of 7 days, during which the cultures were subcultured twice, HGPRT- mutants were selected by plating in hypoxanthine-free medium containing 5 micrograms of 6-thioguanine per ml, at a density of 2 X 10(5) cells per 100 mm dish.	Thioguanine	183-196	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	88-93
3924393-2	1985	To explore this approach, we measured SCE induction in V79 Chinese hamster lung cells and the frequency of mutation to 6-thioguanine resistance at the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus in a cell-mediated mutation assay.	Thioguanine	119-132	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	151-197
2991767-0	1985	Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes.	Thioguanine	54-67	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	19-23
2991767-4	1985	The thioguanine-resistant T cell stably lack hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity, suggesting that they are somatic equivalents in normal individuals to cells from individuals with the X-chromosomal hprt Lesch-Nyhan germinal mutation.	Thioguanine	4-15	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	45-91
2991767-4	1985	The thioguanine-resistant T cell stably lack hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity, suggesting that they are somatic equivalents in normal individuals to cells from individuals with the X-chromosomal hprt Lesch-Nyhan germinal mutation.	Thioguanine	4-15	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	93-97
2991767-4	1985	The thioguanine-resistant T cell stably lack hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity, suggesting that they are somatic equivalents in normal individuals to cells from individuals with the X-chromosomal hprt Lesch-Nyhan germinal mutation.	Thioguanine	4-15	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	225-229
2991767-5	1985	We now report that in vivo-derived thioguanine-resistant T-cell colonies from a single normal individual show a variety of hprt structural alterations, as determined by Southern blot analysis.	Thioguanine	35-46	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	123-127
3873611-1	1985	A clonogenic assay to quantify thioguanine (TG)-resistant (TGr) spleen lymphocytes in the mouse has been developed to support studies of in vivo mutation affecting the hypoxanthine phosphoribosyltransferase (hprt) locus.	Thioguanine	31-42	thioredoxin reductase 3	Mus musculus	59-62
3873611-1	1985	A clonogenic assay to quantify thioguanine (TG)-resistant (TGr) spleen lymphocytes in the mouse has been developed to support studies of in vivo mutation affecting the hypoxanthine phosphoribosyltransferase (hprt) locus.	Thioguanine	44-46	thioredoxin reductase 3	Mus musculus	59-62
4040605-10	1985	Induction of 6-thioguanine-resistant (HGPRT) mutants at various cisplatin concentrations did not show a clear temperature dependency.	Thioguanine	13-26	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	38-43
2413049-8	1985	In contrast, 6-thioguanine was more inhibitory to RNA synthesis, and treatment with this drug caused a fall in TfR expression.	Thioguanine	13-26	transferrin receptor	Homo sapiens	111-114
3896884-5	1985	After the diet and normalization of TG levels, insulin binding was identical in HTG patients and always lower than in controls.	Thioguanine	36-38	insulin	Homo sapiens	47-54
3839092-6	1985	This suggests that a defect in the suitability of TG-rich particles to serve as a substrate for LPL is not likely to play a role in the development of hypertriglyceridaemia.	Thioguanine	50-52	lipoprotein lipase	Homo sapiens	96-99
4011955-6	1985	The individual peak gastrin responses, in totally (TG) and subtotally (SG) gastrectomized patients, were significantly over basal levels (TG: peak 100.3 +/- 12 vs. basal 62.8 +/- 9.1, P less than 0.005; SG: peak 96.9 +/- 9.4 vs. basal 72.4 +/- 6.8, P less than 0.001; pg/ml, mean +/- S.E.M.).	Thioguanine	51-53	gastrin	Homo sapiens	20-27
6481302-3	1984	The key findings are: (a) Asialo GM1, a major neutral glycolipid constituent of all macrophage populations examined, is accessible to galactose oxidase/NaB3H4 labeling on the surface of TG-elicited and BCG-activated macrophages but not on resident macrophages; (b) GM1 is the predominant ganglioside constituent of the mouse macrophage.	Thioguanine	186-188	coenzyme Q10A	Mus musculus	33-36
3988862-4	1985	The method is simple, rapid and sensitive to below 500 ng ml-1 which is below the levels encountered following a therapeutic dose of 6-thioguanine.	Thioguanine	133-146	interleukin 17F	Homo sapiens	58-62
4022194-5	1985	Statistical analyses showed that sodium nitrite induced more 6-TG-resistant (6-TGr) mutants as compared to the untreated control.	Thioguanine	61-65	thioredoxin reductase 3	Homo sapiens	79-82
3855287-1	1985	Previous work has shown that 6-thioguanine (TGua) is an effective inducer of differentiation of Friend and HL-60 leukemia cells which lack hypoxanthine-guanine phosphoribosyltransferase but is at best only weakly active in inducing maturation in parental wild-type cells.	Thioguanine	29-42	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	139-185
3855287-1	1985	Previous work has shown that 6-thioguanine (TGua) is an effective inducer of differentiation of Friend and HL-60 leukemia cells which lack hypoxanthine-guanine phosphoribosyltransferase but is at best only weakly active in inducing maturation in parental wild-type cells.	Thioguanine	44-48	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	139-185
3912318-4	1985	Preincubation of the antibody treated bone marrow cells with an immunosuppressive factor (SAF) derived from a 6-thioguanine resistant cell line, itself derived from the human T cell line CEM, in contrast, allowed those bone marrow cells to produce a state of chimerism and long term survival.	Thioguanine	110-123	FAS antisense RNA 1	Homo sapiens	90-93
6481302-3	1984	The key findings are: (a) Asialo GM1, a major neutral glycolipid constituent of all macrophage populations examined, is accessible to galactose oxidase/NaB3H4 labeling on the surface of TG-elicited and BCG-activated macrophages but not on resident macrophages; (b) GM1 is the predominant ganglioside constituent of the mouse macrophage.	Thioguanine	186-188	coenzyme Q10A	Mus musculus	265-268
6545382-3	1984	A temperature-sensitive mutant, FT20-M6, a 6-thioguanine-resistant derivative of tsFT20, has heat-labile DNA polymerase alpha.	Thioguanine	43-56	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	105-125
6589046-4	1984	Extensive differentiation, as measured by the reduction of nitroblue tetrazolium, occurred in TG-treated, HL-60 HGPRT-negative cells, whereas no significant increase in the number of nitroblue tetrazolium-positive cells was observed in wild-type HL-60 cells exposed to the purinethiol.	Thioguanine	94-96	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	112-117
6497932-5	1984	These findings extend other observations indicating that HDL2 seems to be the HDL fraction, directly associated with removal of TG-rich particles from the circulation.	Thioguanine	128-130	junctophilin 3	Homo sapiens	57-61
6432307-3	1984	The frequency of 6-thioguanine-resistant mutant cells increased by approximately 9-fold as a result of the treatment with alpha-difluoromethylornithine, a potent inhibitor of ornithine decarboxylase (EC 4.1.1.17).	Thioguanine	17-30	ornithine decarboxylase 1	Homo sapiens	175-198
6589046-8	1984	In contrast, HL-60 HGPRT-negative cells treated with TG accumulated in G1, with 68% of the population located in this phase (i.e., an 80% increase compared to controls), as might be expected for a differentiated population.	Thioguanine	53-55	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	19-24
6609777-2	1984	The results indicated that (a) old mice have seven times more 6-TG-resistant (6-TGr) CFU-S than young mice, (b) the mitogen-induced proliferative activity of 6-TGr T cells is comparable to that of 6-TG-sensitive (6-TGs) T cells of both young and old mice, and (c) 6-TGr CFU-S and T cells are resistant to 6-TG because they are mitotically inactive and not because they are drug-resistant mutants.	Thioguanine	62-66	thioredoxin reductase 3	Mus musculus	80-83
6608383-1	1984	Thioguanine-resistant T lymphoblast populations were selectively amplified using T cell growth factor in the cultures of peripheral blood T cells from four Lesch-Nyhan heterozygotes.	Thioguanine	0-11	interleukin 2	Homo sapiens	81-101
6323325-2	1984	An ouabain- and thioguanine-resistant subline (TIKAUT) of spontaneous AKR lymphoma, TKA, was trisomic for chromosome 15 and contained a single 33 kb EcoRI fragment, containing the oncogene c-myc.	Thioguanine	16-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	189-194
6496222-8	1984	In excision repair-deficient CHO cells, Trp-P-2 exposure caused cytotoxicity, mutagenicity (thioguanine and azaadenine resistances), sister chromatid exchange, and chromosomal aberrations at concentrations more than 30-fold lower than those for IQ.	Thioguanine	92-103	polycystin 2, transient receptor potential cation channel	Homo sapiens	40-47
6583852-2	1984	Two different types of 6-thioguanine (TG) -resistant derivatives of these A9 X PHC-3A hybrids (LP), are generated in regard to PH gene expression.	Thioguanine	23-36	phenylalanine hydroxylase	Mus musculus	79-81
6690915-3	1984	In PHA-stimulated samples from the same persons the frequency of 6-thioguanine (TG)-resistant variants was between 4 X 10(-7) and 2.6 X 10(-6), which indicates that most of the spontaneously cycling cells were TG-sensitive.	Thioguanine	65-78	lamin B receptor	Homo sapiens	3-6
6690915-3	1984	In PHA-stimulated samples from the same persons the frequency of 6-thioguanine (TG)-resistant variants was between 4 X 10(-7) and 2.6 X 10(-6), which indicates that most of the spontaneously cycling cells were TG-sensitive.	Thioguanine	80-82	lamin B receptor	Homo sapiens	3-6
6690915-4	1984	With lymphocytes from one of the referents it was found that: (i) in the presence of 2 X 10(-4) M TG, more than 97% of the spontaneously cycling cells were inhibited before or in early S phase, and (ii) when a flow cytometer was set to sort out TG-resistant cells in late S + G2 phase after 48 h incubation in medium with PHA, the contribution of TG-resistant cells from the spontaneously cycling fraction amounted to less than 2% of the total number of resistant cells.	Thioguanine	98-100	lamin B receptor	Homo sapiens	322-325
6583852-2	1984	Two different types of 6-thioguanine (TG) -resistant derivatives of these A9 X PHC-3A hybrids (LP), are generated in regard to PH gene expression.	Thioguanine	38-40	phenylalanine hydroxylase	Mus musculus	79-81
6656829-2	1983	To quantify the mutation induction in V79 cells mutants deficient in the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected with the purine analogue 6-thioguanine (6-TG).	Thioguanine	175-188	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	80-127
6656829-2	1983	To quantify the mutation induction in V79 cells mutants deficient in the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected with the purine analogue 6-thioguanine (6-TG).	Thioguanine	175-188	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	129-134
6656829-2	1983	To quantify the mutation induction in V79 cells mutants deficient in the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected with the purine analogue 6-thioguanine (6-TG).	Thioguanine	190-194	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	80-127
6583852-3	1984	In regular growth medium supplemented with 10(-4) M TG (Tyr+/TG), TGr derivatives, all of which continue to express PH, occur with high frequency (approximately equal to 10(-3).	Thioguanine	52-54	thioredoxin reductase 3	Mus musculus	66-69
6656829-2	1983	To quantify the mutation induction in V79 cells mutants deficient in the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected with the purine analogue 6-thioguanine (6-TG).	Thioguanine	190-194	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	129-134
6583852-3	1984	In regular growth medium supplemented with 10(-4) M TG (Tyr+/TG), TGr derivatives, all of which continue to express PH, occur with high frequency (approximately equal to 10(-3).	Thioguanine	52-54	phenylalanine hydroxylase	Mus musculus	116-118
6583852-3	1984	In regular growth medium supplemented with 10(-4) M TG (Tyr+/TG), TGr derivatives, all of which continue to express PH, occur with high frequency (approximately equal to 10(-3).	Thioguanine	61-63	thioredoxin reductase 3	Mus musculus	66-69
6831637-3	1983	Mutations at, or affecting, the hypoxanthine-guanine phosphoribosyltransferase locus were scored by resistance to 6-thioguanine.	Thioguanine	114-127	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	32-78
6865989-0	1983	8-Azaguanine versus 6-thioguanine: influence on frequency and expression time of induced HGPRT- mutations in Chinese hamster V79 cells.	Thioguanine	20-33	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	89-94
6400065-3	1983	In an analogous manner, 6-thioguanine induced effective erythroid and granulocytic differentiation of Friend and HL-60 leukemias, respectively, only in hypoxanthine-guanine phosphoribosyltransferase deficient cells.	Thioguanine	24-37	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	152-198
6400065-5	1983	Erythrodifferentiation of HGPRT negative Friend murine leukemia cells by 6-thioguanine was antagonized by tetracaine, d, 1-propranolol and 12-O-tetradecanoylphorbol-13-acetate, providing evidence for a cell membrane mediated component in the action of the purine antimetabolite.	Thioguanine	73-86	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	26-31
6308439-7	1983	The mutagenic response of the AK locus to these agents compared favorably with that of the HGPRT locus (6-thioguanine resistance) within the same experiments.	Thioguanine	104-117	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	91-96
6850580-2	1983	The mutation frequency in Chinese hamster ovary cells at the hypoxanthine-guanine phosphoribosyltransferase locus was measured using resistance to 6-thioguanine.	Thioguanine	147-160	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	61-107
7144801-2	1982	Mutants with the phenotype deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT) were selected in 6-thoiguanine(TG)-containing medium and isolated.	Thioguanine	126-128	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	40-87
7144801-2	1982	Mutants with the phenotype deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT) were selected in 6-thoiguanine(TG)-containing medium and isolated.	Thioguanine	126-128	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	89-93
7051712-5	1982	G-HbA1 was significantly correlated to fasting plasma glucose and glucose in urine, but also to WS-TG and VLDL-TG.	Thioguanine	99-101	hemoglobin subunit alpha 1	Homo sapiens	2-6
6184146-5	1982	Enterotoxin specific activity was increased for three strains by adding papaverine (hydrochloride crystalline), for two strains by adding each of caffeine and 3-isobutyl-l-methylxanthine, for one strain by adding each of theophylline, 6-mercaptopurine, and 2-amino-6-mercaptopurine, and for none of the strains by adding imidazole.	Thioguanine	257-281	cpe	Clostridium perfringens	0-11
6811889-5	1982	Lines resistant to 6-thioguanine (TGr) and 5-bromo-2"-deoxyuridine (BUr) were isolated from L5178Y and these three mutagen -sensitive mutants.	Thioguanine	19-32	thioredoxin reductase 3	Mus musculus	34-37
7074877-9	1982	Our results suggest that a second-site mutation in the mutant beta-actin of HUT-14 was selected for during a subcloning step in the presence of 6-thioguanine before derivation of the HUT-14T substrain.	Thioguanine	144-157	POTE ankyrin domain family member F	Homo sapiens	62-72
6895910-4	1982	With this method, TPO-catalyzed iodination of Tg and thyroid hormone formation were measured simultaneously from eight normal thyroid glands and 15 thyroid glands from MMI-treated patients with Graves" disease.	Thioguanine	46-48	thyroid peroxidase	Homo sapiens	18-21
7049670-1	1982	The effect of cytotoxic therapy (including cytosine-arabinoside and thioguanine) on the adrenal response to insulin-induced hypoglycemia has been investigated in 15 newly diagnosed patients with an acute form of leukemia.	Thioguanine	68-79	insulin	Homo sapiens	108-115
7087998-1	1982	HGPRT enzyme activity in mutant colonies selected in 6-thioguanine can be assessed directly in petri dishes using an autoradiographic method.	Thioguanine	53-66	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-5
7087998-2	1982	The application of this method to large-scale quantitative mutation experiments verifies that: (a) the maximum induced frequency of mutation of HGPRT-deficiency can be measured at short expression times, such as 3 days after treatment, when cells are respread into relatively low thioguanine concentrations, and (b) ionizing radiation induces predominantly mutants with zero HGPRT activity.	Thioguanine	280-291	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	144-149
7117212-0	1982	Phenotypic expression time of mutagen-induced 6-thioguanine resistance in Chinese hamster ovary cells (CHO/HGPRT system): expression in division-arrested cell cultures.	Thioguanine	46-59	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	107-112
7094197-0	1982	Pharmacokinetics and metabolism of beta-2"-deoxythioguanosine and 6-thioguanine in man.	Thioguanine	66-79	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	35-41
7094197-2	1982	However, a new agent, beta-2"-deoxythioguanosine (beta-TGdR) can overcome TG resistance in animal tumor models and is therefore of potential clinical use.	Thioguanine	55-57	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
7117215-2	1982	A chinese hamster ovary (CHO) cell line heterozygous at the adenine phosphoribosyl transferase (APRT) locus was used for selection of induced mutants resistant to 8-azaadenine (8AA), 6-thioguanine (6TG), ouabain (OUA), emetine (EMT) and diphtheria toxin (DIP).	Thioguanine	183-196	adenine phosphoribosyltransferase	Cricetulus griseus	60-94
7117215-2	1982	A chinese hamster ovary (CHO) cell line heterozygous at the adenine phosphoribosyl transferase (APRT) locus was used for selection of induced mutants resistant to 8-azaadenine (8AA), 6-thioguanine (6TG), ouabain (OUA), emetine (EMT) and diphtheria toxin (DIP).	Thioguanine	183-196	adenine phosphoribosyltransferase	Cricetulus griseus	96-100
7117215-2	1982	A chinese hamster ovary (CHO) cell line heterozygous at the adenine phosphoribosyl transferase (APRT) locus was used for selection of induced mutants resistant to 8-azaadenine (8AA), 6-thioguanine (6TG), ouabain (OUA), emetine (EMT) and diphtheria toxin (DIP).	Thioguanine	198-201	adenine phosphoribosyltransferase	Cricetulus griseus	60-94
7117215-2	1982	A chinese hamster ovary (CHO) cell line heterozygous at the adenine phosphoribosyl transferase (APRT) locus was used for selection of induced mutants resistant to 8-azaadenine (8AA), 6-thioguanine (6TG), ouabain (OUA), emetine (EMT) and diphtheria toxin (DIP).	Thioguanine	198-201	adenine phosphoribosyltransferase	Cricetulus griseus	96-100
7117212-1	1982	The phenotypic expression time of ethyl methanesulfonate (EMS) induced 6-thioguanine-resistant mutants was studied with Chinese hamster ovary cells in culture (CHO/HGPRT system).	Thioguanine	71-84	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	164-169
7197551-1	1981	6-Mercaptopurine and 6-thioguanine strongly inhibited the zero-trans entry of hypoxanthine into Novikoff rat hepatoma cells which lacked hypoxanthine/guanine phosphoribosyltransferase, whereas 8-azaguanine had no significant effect.	Thioguanine	21-34	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	137-183
7160342-0	1982	Effect of selection cell density on the recovery of mutagen-induced 6-thioguanine-resistant cells (CHO/HGPRT system).	Thioguanine	68-81	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	103-108
6947233-2	1981	A subclone of these simian virus 40 (SV40)-transformed cells (6TGR-SV-tfm) selected in 6-thioguanine and lacking hypoxanthine phosphoribosyltransferase was used to produce a series of mouse--human hybrids containing the normal human X chromosome or various X autosome-translocation chromosomes (expressing only segments of the human X chromosome).	Thioguanine	87-100	androgen receptor	Mus musculus	70-73
7273856-2	1981	8-Azaguanine and 6-thioguanine are synthetic analogs of guanine and are lethal to cells with normal hypoxanthine phosphoribosyltransferase (HPRT) activity.	Thioguanine	17-30	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-138
6975673-4	1981	Among splenic T cells, TG-depleted cell fractions were superior to TG-enriched cell fractions in producing TCGF upon PHA stimulation.	Thioguanine	23-25	interleukin 2	Homo sapiens	107-111
7029263-8	1981	Many studies depend on selecting for 8-azaguanine- or 6-thioguanine-resistant mutants, which are due to mutations in the HGPRT locus present in a single active copy on the X-chromosome.	Thioguanine	54-67	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	121-126
7027497-1	1981	Fusion of 6-thioguanine-resistant mouse neuroblastoma to HeLa whole and minicells generated neuroblastoma HPRT revertants in addition to true cell hybrids.	Thioguanine	10-23	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	106-110
6257380-6	1981	Mutant cells lacking hypoxanthine-guanine phosphoribosyltransferase were selected by their resistance to 6-thioguanine.	Thioguanine	105-118	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	21-67
7273856-2	1981	8-Azaguanine and 6-thioguanine are synthetic analogs of guanine and are lethal to cells with normal hypoxanthine phosphoribosyltransferase (HPRT) activity.	Thioguanine	17-30	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	140-144
7207481-10	1981	Our data suggest that azaguanine and thioguanine may select for mutations at different sites on the HGPRT molecule in V79 cells and provide possible explanations for the differences in effectiveness of these two agents reported in other cell lines.	Thioguanine	37-48	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	100-105
6248594-2	1980	TG cells (suppressor cells) have 39% of the ecto-5"-NT activity of Tnon-G cells (helper cells) but the increase in numbers of TG cells that occurs with age explains only about 14% of the age-related fall in T lymphocyte ecto-5"-NT activity.	Thioguanine	0-2	5'-nucleotidase ecto	Homo sapiens	44-54
7009368-7	1980	This technique allowed a study of the acute effect of insulin on the hepatic extraction of substrates and on the hepatic production of VLDL-TG.	Thioguanine	140-142	insulin	Homo sapiens	54-61
7009368-10	1980	During a one-hour observation period after the application of insulin, the production of VLDL-TG was decreased in controls and increased in patients with endogenous hypertriglyceridemia.	Thioguanine	94-96	insulin	Homo sapiens	62-69
6248594-2	1980	TG cells (suppressor cells) have 39% of the ecto-5"-NT activity of Tnon-G cells (helper cells) but the increase in numbers of TG cells that occurs with age explains only about 14% of the age-related fall in T lymphocyte ecto-5"-NT activity.	Thioguanine	0-2	5'-nucleotidase ecto	Homo sapiens	220-230
7394700-1	1980	Cellular resistance to 6-thioguanine is almost always associated with a complete loss of hypoxanthine phosphoribosyltransferase (HPRT) activity, while resistance to 8-azaguanine has frequently been shown to occur independently of any changes in the HPRT activity.	Thioguanine	23-36	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	129-133
7394700-5	1980	We also present evidence which shows that such mutants arise through a mutation that specifically alters the HPRT molecule so that the enzyme no longer recognizes 8-azaguanine as a substrate, while remaining catalytically functional with hypoxanthine and 6-thioguanine.	Thioguanine	255-268	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	109-113
22282999-1	1980	light from a 6-thioguanine resistant HGPRT deficient V79 Chinese hamster cell line.	Thioguanine	13-26	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	37-42
7384171-4	1980	Inhibitors of guanine deaminase are important because it is reasonable to postulate that it will inhibit the conversion of 8-azaguanine to 8-azaxanthine and these could be used with advantage along with thioguanine and 8-azaguanine.	Thioguanine	203-214	guanine deaminase	Homo sapiens	14-31
6119798-2	1980	The autoradiographic determination of purine analogue (8-azaguanine; 6-thioguanine) resistant (AGr; TGr) peripheral blood lymphocytes (PBLs) arising in vivo in man is proposed as a candidate test.	Thioguanine	69-82	thioredoxin reductase 3	Homo sapiens	100-103
569123-4	1978	When infected with any of these mycoplasma species, HPRT-deficient mouse cell mutants rapidly acquired a cell-associated HPRT activity; however, the cells remained sensitive to HAT medium and resistant to 6-thioguanine.	Thioguanine	205-218	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	52-56
539455-7	1979	The high post-race LPL activity in less trained subjects indicates a higher capacity for uptake of fatty acids from serum TG as compared to the more trained subjects.	Thioguanine	122-124	lipoprotein lipase	Homo sapiens	19-22
762202-1	1979	Cellular resistance to the cytotoxic purine analogues 8-azaguanine (AG) and 6-thioguanine (TG) is usually mediated by a mutation leading to the loss or reduction in hypoxanthine phosphoribosyltransferase (HPRT) activity.	Thioguanine	76-89	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	205-209
762202-1	1979	Cellular resistance to the cytotoxic purine analogues 8-azaguanine (AG) and 6-thioguanine (TG) is usually mediated by a mutation leading to the loss or reduction in hypoxanthine phosphoribosyltransferase (HPRT) activity.	Thioguanine	91-93	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	205-209
569256-0	1978	Do radiation-induced thioguanine-resistant mutants of cultured mammalian cells arise by HGPRT gene mutation or X-chromosome rearrangement?	Thioguanine	21-32	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	88-93
7099189-2	1982	Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hgprt) locus was determined by selection for 6-thioguanine resistant (TGr) mutants (CHO/HGPRT system).	Thioguanine	120-133	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	26-73
7099189-2	1982	Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hgprt) locus was determined by selection for 6-thioguanine resistant (TGr) mutants (CHO/HGPRT system).	Thioguanine	120-133	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	75-80
372789-0	1979	Phenotypic expression time of mutagen-induced 6-thioguanine resistance in Chinese hamster ovary cells (CHO/HGPRT system).	Thioguanine	46-59	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	107-112
569123-8	1978	Compared to the animal cell enzymes, the mycoplasmal HPRT activities are less heat stable, more strongly inhibited by 6-thioguanine, and in general migrate more slowly in electrophoresis at a neutral pH.	Thioguanine	118-131	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	53-57
746337-7	1978	There is a positive linear correlation between TG and LCAT secretion in cell preparations from rats operated on with ventromedial hypothalamic lesions.	Thioguanine	47-49	lecithin cholesterol acyltransferase	Rattus norvegicus	54-58
657528-2	1978	Both 6-mercaptopurine and 6-thioguanine were substrates for the TPMT activity in the human RBC.	Thioguanine	26-39	thiopurine S-methyltransferase	Homo sapiens	64-68
347279-2	1978	A hypothesis is advanced that expression of the 6-thioguanine-resistant state may require the removal of essentially all pre-existing hypoxanthine--guanine phosphoribosyl transferase (HGPRT) molecules via division, dilution, and protein turnover.	Thioguanine	48-61	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	134-182
347279-2	1978	A hypothesis is advanced that expression of the 6-thioguanine-resistant state may require the removal of essentially all pre-existing hypoxanthine--guanine phosphoribosyl transferase (HGPRT) molecules via division, dilution, and protein turnover.	Thioguanine	48-61	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	184-189
18484-0	1977	Reversion in expression of hypoxanthine-guanine phosphoribosyltransferase in 6-thioguanine resistant neuroblastoma: evidence for reduced enzyme levels associated with unaltered catalytic activity.	Thioguanine	77-90	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	27-73
719181-1	1978	HGPRT-deficient mutants of chinese hamster cells and human skin fibroblasts are selected with 6-thioguanine after treatment with the combination 8-MOP and UVA.	Thioguanine	94-107	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	0-5
917038-1	1977	An assay is described for the measurement of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells utilizing resistance to 6-thioguanine (TG).	Thioguanine	194-207	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	71-118
917038-1	1977	An assay is described for the measurement of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells utilizing resistance to 6-thioguanine (TG).	Thioguanine	194-207	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	120-125
917038-1	1977	An assay is described for the measurement of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells utilizing resistance to 6-thioguanine (TG).	Thioguanine	209-211	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	71-118
917038-1	1977	An assay is described for the measurement of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells utilizing resistance to 6-thioguanine (TG).	Thioguanine	209-211	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	120-125
870191-3	1977	This effect appeared to be the result of a decrease, caused by 6-thioguanine, in the induction of several enzyme activities (i.e., thymidine kinase, deoxycytidylate deaminase, cytidine diphosphate reductase, and DNA polymerase) necessary for the initiation of DNA replication in regenerating liver.	Thioguanine	63-76	dCMP deaminase	Rattus norvegicus	149-174
560213-3	1977	Mutant cells are resistant to 6-thioguanine at 33-39 degrees C and sensitive to hypoxanthine-aminopterin-thymidine at 37-39 degrees C, but not at 33 degrees C. We hypothesize that a single structural mutation of HPRT can explain these results.	Thioguanine	30-43	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	212-216
331095-0	1977	Dilution of hypoxanthine-guanine phosphoribosyl transferase and other factors affecting the frequency of 6-thioguanine resistance in Chinese hamster lung cells.	Thioguanine	105-118	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	12-59
754871-6	1977	An example is the isolation, by 6-thioguanine resistance, of cells deficient in hypoxanthine-guanine phosphoribosyl transferase -- the same deficiency that characterizes human patients with the X-linked Lesch-Nyhan disease.	Thioguanine	32-45	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	80-127
950955-1	1976	Mutant clones of human diploid fibroblasts deficient in the enzyme, hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected by their ability to grow in medium containing the cytotoxic purine analogue, 6-thioguanine (6TG).	Thioguanine	215-228	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	68-115
950955-1	1976	Mutant clones of human diploid fibroblasts deficient in the enzyme, hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected by their ability to grow in medium containing the cytotoxic purine analogue, 6-thioguanine (6TG).	Thioguanine	215-228	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	117-122
950955-1	1976	Mutant clones of human diploid fibroblasts deficient in the enzyme, hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected by their ability to grow in medium containing the cytotoxic purine analogue, 6-thioguanine (6TG).	Thioguanine	230-233	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	68-115
950955-1	1976	Mutant clones of human diploid fibroblasts deficient in the enzyme, hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected by their ability to grow in medium containing the cytotoxic purine analogue, 6-thioguanine (6TG).	Thioguanine	230-233	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	117-122
950955-3	1976	Nine spontaneous and four radiation-induced 6TG-resistant mutants had less than 2% of the parental strain HGPRT activity and were unable to grow in medium containing azaserine.	Thioguanine	44-47	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	106-111
950955-5	1976	Evidence is presented to show that 6TG is a better selective agent than 8-aza-guanine (8AG) for HGPRT-deficient mutants of human diploid fibroblasts.	Thioguanine	35-38	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	96-101
1028169-3	1976	A cell line, THO2, was isolated from Balb/3T3 clone A31 after sequential nitrosoguanidine treatments and selection for resistance to 6-thioguanine and ouabain.	Thioguanine	133-146	THO complex 2	Mus musculus	13-17
52568-3	1975	The cells of the latter clone, which was isolated after selection in the presence of thioguanine, are deficient in the enzyme hypoxanthine-guanine-phosphoribosyl transferase.	Thioguanine	85-96	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	126-173
4357617-3	1974	Hypertriglyceridemia is one of the metabolic abnormalities proposed to accompany obesity, and in order to help explain the mechanisms leading to this abnormality we have proposed the following sequential hypothesis: insulin resistance --> hyperinsulinemia --> accelerated hepatic triglyceride(TG) production --> elevated plasma TG concentrations.	Thioguanine	299-301	insulin	Homo sapiens	216-223
4357617-3	1974	Hypertriglyceridemia is one of the metabolic abnormalities proposed to accompany obesity, and in order to help explain the mechanisms leading to this abnormality we have proposed the following sequential hypothesis: insulin resistance --> hyperinsulinemia --> accelerated hepatic triglyceride(TG) production --> elevated plasma TG concentrations.	Thioguanine	337-339	insulin	Homo sapiens	216-223
33666949-10	2021	Compared with TG, LC-CS could upregulate the expression of CYP19, CYP17, AR and SRD5A2 proteins and mRNA.	Thioguanine	14-16	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	59-64
33222120-6	2021	RESULTS: All 14 patients with structural disease and underestimated levels of Tg-IMA presented detectable Tg-c levels.	Thioguanine	78-80	transglutaminase 2	Homo sapiens	106-110
33906076-16	2021	CONCLUSION: TG potentiated 5-FU"s inhibitory activity to human colorectal cancer through arresting cell cycle progression and inducing p53-mediated apoptosis, which may present a novel strategy in CRC therapies and contribute to the optimizing clinical application of 5-FU.	Thioguanine	12-14	tumor protein p53	Homo sapiens	135-138
203649-2	1978	Since the hybrids were originally derived by the hypoxanthine aminopterin thymidine selection scheme, counter selection experiments on 6-thioguanine result in preferential survival of hybrid cells which have spontaneously lost the feline X-chromosome on which is located the structural gene for hypoxanthine guanine phosphoribosyl transferase (IMP: pyrophosphate phosphoribosyl transferase, E.C.	Thioguanine	135-148	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	295-342
1157053-1	1975	The effects of 6-thioguanine on purine biosynthesis and cell viability have been examined in H.Ep.	Thioguanine	15-28	histocompatibility 51	Mus musculus	93-97
1235913-4	1975	That the UV-induced mutations to 6-thioguanine resistance affects the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus is supported by the observation that all randomly isolated drug-resistant colonies contained highly reduced or undetectable HGPRT activity.	Thioguanine	33-46	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	70-117
1235913-4	1975	That the UV-induced mutations to 6-thioguanine resistance affects the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus is supported by the observation that all randomly isolated drug-resistant colonies contained highly reduced or undetectable HGPRT activity.	Thioguanine	33-46	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	119-124
1235913-4	1975	That the UV-induced mutations to 6-thioguanine resistance affects the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus is supported by the observation that all randomly isolated drug-resistant colonies contained highly reduced or undetectable HGPRT activity.	Thioguanine	33-46	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	256-261
194347-5	1975	Biochemical analyses demonstrate that most of the randomly isolated 6-thioguanine-resistant variants possess a highly reduced or undetectable level of HGPRT activity suggesting that the EMS-induced mutations to 6-thioguanine resistance affect primarily, if not exclusively, the HGPRT locus.	Thioguanine	68-81	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	151-156
194347-5	1975	Biochemical analyses demonstrate that most of the randomly isolated 6-thioguanine-resistant variants possess a highly reduced or undetectable level of HGPRT activity suggesting that the EMS-induced mutations to 6-thioguanine resistance affect primarily, if not exclusively, the HGPRT locus.	Thioguanine	68-81	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	278-283
194347-5	1975	Biochemical analyses demonstrate that most of the randomly isolated 6-thioguanine-resistant variants possess a highly reduced or undetectable level of HGPRT activity suggesting that the EMS-induced mutations to 6-thioguanine resistance affect primarily, if not exclusively, the HGPRT locus.	Thioguanine	211-224	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	151-156
194347-5	1975	Biochemical analyses demonstrate that most of the randomly isolated 6-thioguanine-resistant variants possess a highly reduced or undetectable level of HGPRT activity suggesting that the EMS-induced mutations to 6-thioguanine resistance affect primarily, if not exclusively, the HGPRT locus.	Thioguanine	211-224	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	278-283
33666949-4	2021	Compared with TG group, LC-CS could upregulate protein and mRNA expression of CYP19, CYP17, AR and SRD5A2.	Thioguanine	14-16	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	78-83
34032712-2	2021	Determining the factors associated with the severity of HTGP was necessary and important in the management of patients with AP.This study aims to examine the clinical and biochemical characteristics of HTGP patients, and to determine the factors associated with the severity of HTGP according to the revised Atlanta classification.This retrospective and prospective study enrolled 157 HTGP patients from January 2016 to May 2019 at Cho Ray Hospital who had serum TG levels measured within the first 48 hours of admittance with a TG concentration >= 1000 mg/dL and excluded other causes.	Thioguanine	57-59	transglutaminase 4	Homo sapiens	202-206
34032712-2	2021	Determining the factors associated with the severity of HTGP was necessary and important in the management of patients with AP.This study aims to examine the clinical and biochemical characteristics of HTGP patients, and to determine the factors associated with the severity of HTGP according to the revised Atlanta classification.This retrospective and prospective study enrolled 157 HTGP patients from January 2016 to May 2019 at Cho Ray Hospital who had serum TG levels measured within the first 48 hours of admittance with a TG concentration >= 1000 mg/dL and excluded other causes.	Thioguanine	57-59	transglutaminase 4	Homo sapiens	202-206
34032712-2	2021	Determining the factors associated with the severity of HTGP was necessary and important in the management of patients with AP.This study aims to examine the clinical and biochemical characteristics of HTGP patients, and to determine the factors associated with the severity of HTGP according to the revised Atlanta classification.This retrospective and prospective study enrolled 157 HTGP patients from January 2016 to May 2019 at Cho Ray Hospital who had serum TG levels measured within the first 48 hours of admittance with a TG concentration >= 1000 mg/dL and excluded other causes.	Thioguanine	57-59	transglutaminase 4	Homo sapiens	202-206
34032712-2	2021	Determining the factors associated with the severity of HTGP was necessary and important in the management of patients with AP.This study aims to examine the clinical and biochemical characteristics of HTGP patients, and to determine the factors associated with the severity of HTGP according to the revised Atlanta classification.This retrospective and prospective study enrolled 157 HTGP patients from January 2016 to May 2019 at Cho Ray Hospital who had serum TG levels measured within the first 48 hours of admittance with a TG concentration >= 1000 mg/dL and excluded other causes.	Thioguanine	203-205	transglutaminase 4	Homo sapiens	56-60
34013320-5	2021	Agt-Tg displayed raised BP in acute recordings, while long-term telemetrically measured basal BP was indistinguishable from wildtypes.	Thioguanine	4-6	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-3
33888830-8	2021	Furthermore, HFD Pgrmc1 KO mice resulted in high cardiac fatty acyl-CoA levels and TG level.	Thioguanine	83-85	progesterone receptor membrane component 1	Mus musculus	17-23
33910097-4	2021	Compared with RG, the abundance values of AA2, AA10, GH1, GH10 in TG increased by 15.18%, 29.28%, 31.08%, 21.65%, respectively.	Thioguanine	66-68	somatotropin	Bos taurus	53-56
34018365-18	2021	Conclusion: Hyperin improved ovarian reserve in TG-induced POI mice through Nrf-2/HO-1antioxidant stress response and the anti-apoptotic effect of PI3K/Akt pathways.	Thioguanine	48-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-81
34018365-18	2021	Conclusion: Hyperin improved ovarian reserve in TG-induced POI mice through Nrf-2/HO-1antioxidant stress response and the anti-apoptotic effect of PI3K/Akt pathways.	Thioguanine	48-50	heme oxygenase 1	Mus musculus	82-86
33927259-2	2021	The aim of the study was to investigate the influence of 36-month therapy with TNF-alpha inhibitors (adalimumab, etanercept, infliximab) on the levels of adipokines (resistin, adiponectin, leptin) and lipids (TG, cholesterol, LDL, HDL) in 37 psoriasis patients and 30 healthy controls.	Thioguanine	209-211	tumor necrosis factor	Homo sapiens	79-88
33921773-14	2021	Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFalpha (p = 10-7) and IL-6 (p = 3 x 10-6) being those that most significantly changed.	Thioguanine	93-95	tumor necrosis factor	Homo sapiens	136-144
33517014-8	2021	EP and NE, where most freshwater aquatic products in China are harvested, accounted for 58.2% and 22.9%, respectively, of the THg burial flux.	Thioguanine	126-129	epiregulin	Homo sapiens	0-2
33094480-9	2021	Small interfering RNA of SEPP1 inhibited TG accumulation by activating adenosine monophosphate activated protein kinase/acetyl-CoA carboxylase (AMPK/ACC), and overexpression of SEPP1 aggravated lipid accumulation and inhibited AMPK/ACC phosphorylation.	Thioguanine	41-43	selenoprotein P	Homo sapiens	25-30
33094480-9	2021	Small interfering RNA of SEPP1 inhibited TG accumulation by activating adenosine monophosphate activated protein kinase/acetyl-CoA carboxylase (AMPK/ACC), and overexpression of SEPP1 aggravated lipid accumulation and inhibited AMPK/ACC phosphorylation.	Thioguanine	41-43	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	144-148
34017413-10	2021	Correlation analysis revealed that both CD3+ and CD4+ had a negative correlation with FPG, HbA1C, FINS, HOMA-IR, TG, TC, HDL and LDL, while CK-18 had a positive correlation with these indexes.	Thioguanine	113-115	CD4 molecule	Homo sapiens	49-52
33338591-2	2021	In our previous study, we suggest that TG decoction possibly exerts an anti-apoptotic effect on hypothalamic neurons of ovariectomized rats via the ASK1/MKK7/JNK pathway.	Thioguanine	39-41	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	148-152
33855731-0	2021	Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin.	Thioguanine	62-64	adiponectin, C1Q and collagen domain containing	Mus musculus	85-96
33826740-1	2021	The genomic landscape neighboring large deletions including the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus on human X chromosome in 6-thioguanine-resistant mutants originating from immortalized human fibroblast cells exposed to X rays was characterized by real-time quantitative PCR (qPCR)-based analyses.	Thioguanine	150-163	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	64-111
33826740-1	2021	The genomic landscape neighboring large deletions including the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus on human X chromosome in 6-thioguanine-resistant mutants originating from immortalized human fibroblast cells exposed to X rays was characterized by real-time quantitative PCR (qPCR)-based analyses.	Thioguanine	150-163	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	113-117
33856595-10	2021	CONCLUSION: Taken together, inhibition of CHOP may inhibit the proliferation and migration of VSMCs as well as reduce the levels of TC, TG, and LDL-C but increase the level of HDL-C through the TRIB3/miR-208/TIMP3 axis, thereby inhibiting the progression of atherosclerosis.	Thioguanine	136-138	DNA-damage inducible transcript 3	Mus musculus	42-46
33850298-5	2021	In patients with an eGFR decrement >25%, plus a decline in GFR category and TDF discontinuation, a difference was observed for ABCC4 c.*38T>G (35 subjects TG + GG vs. 18 TT, p = 0.052).	Thioguanine	155-157	epidermal growth factor receptor	Homo sapiens	20-24
33850298-5	2021	In patients with an eGFR decrement >25%, plus a decline in GFR category and TDF discontinuation, a difference was observed for ABCC4 c.*38T>G (35 subjects TG + GG vs. 18 TT, p = 0.052).	Thioguanine	155-157	ATP binding cassette subfamily C member 4	Homo sapiens	127-132
33338591-2	2021	In our previous study, we suggest that TG decoction possibly exerts an anti-apoptotic effect on hypothalamic neurons of ovariectomized rats via the ASK1/MKK7/JNK pathway.	Thioguanine	39-41	mitogen-activated protein kinase 8	Rattus norvegicus	158-161
33338591-2	2021	In our previous study, we suggest that TG decoction possibly exerts an anti-apoptotic effect on hypothalamic neurons of ovariectomized rats via the ASK1/MKK7/JNK pathway.	Thioguanine	39-41	mitogen activated protein kinase kinase 7	Rattus norvegicus	153-157
33338591-11	2021	RESULTS: Application of TG decoction mitigated the GT1-7 cell apoptosis and injury caused by TBTC; besides, it inhibited the activation of the ASK1/MKK7/JNK pathway.	Thioguanine	24-26	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	51-56
33338591-11	2021	RESULTS: Application of TG decoction mitigated the GT1-7 cell apoptosis and injury caused by TBTC; besides, it inhibited the activation of the ASK1/MKK7/JNK pathway.	Thioguanine	24-26	mitogen-activated protein kinase kinase kinase 5	Mus musculus	143-147
33205673-4	2021	The levels of the cytotoxic DNA-incorporated thioguanine were significantly higher on day 70-79 in G460A/A719G TPMT heterozygous (TPMT HZ) compared to TPMT wild type (TPMT WT) patients (mean: 230.7 vs. 149.7 fmol/microg DNA, p = 0.002).	Thioguanine	45-56	thiopurine S-methyltransferase	Homo sapiens	111-115
33338591-11	2021	RESULTS: Application of TG decoction mitigated the GT1-7 cell apoptosis and injury caused by TBTC; besides, it inhibited the activation of the ASK1/MKK7/JNK pathway.	Thioguanine	24-26	mitogen-activated protein kinase kinase 7	Mus musculus	148-152
33338591-11	2021	RESULTS: Application of TG decoction mitigated the GT1-7 cell apoptosis and injury caused by TBTC; besides, it inhibited the activation of the ASK1/MKK7/JNK pathway.	Thioguanine	24-26	mitogen-activated protein kinase 8	Mus musculus	153-156
33522396-6	2021	Further, TG 54:3 and the singly-labeled molecules demonstrated higher plasma absolute entry rates differing significantly across fat levels within a single TG species (P<0.01).	Thioguanine	9-11	FAT atypical cadherin 1	Homo sapiens	129-132
33205673-4	2021	The levels of the cytotoxic DNA-incorporated thioguanine were significantly higher on day 70-79 in G460A/A719G TPMT heterozygous (TPMT HZ) compared to TPMT wild type (TPMT WT) patients (mean: 230.7 vs. 149.7 fmol/microg DNA, p = 0.002).	Thioguanine	45-56	thiopurine S-methyltransferase	Homo sapiens	130-134
33205673-4	2021	The levels of the cytotoxic DNA-incorporated thioguanine were significantly higher on day 70-79 in G460A/A719G TPMT heterozygous (TPMT HZ) compared to TPMT wild type (TPMT WT) patients (mean: 230.7 vs. 149.7 fmol/microg DNA, p = 0.002).	Thioguanine	45-56	thiopurine S-methyltransferase	Homo sapiens	130-134
33205673-4	2021	The levels of the cytotoxic DNA-incorporated thioguanine were significantly higher on day 70-79 in G460A/A719G TPMT heterozygous (TPMT HZ) compared to TPMT wild type (TPMT WT) patients (mean: 230.7 vs. 149.7 fmol/microg DNA, p = 0.002).	Thioguanine	45-56	thiopurine S-methyltransferase	Homo sapiens	130-134
33753169-4	2021	Recently, the small molecule NUDT15 inhibitor TH1760 has been shown to sensitize cells to thiopurines, through enhanced accumulation of 6-thio-guanine in DNA.	Thioguanine	136-150	nudix hydrolase 15	Homo sapiens	29-35
33714975-3	2021	6-TG is metabolized by thiopurine methyltransferase (TPMT) which underlies clinically relevant genetic polymorphism.	Thioguanine	0-4	thiopurine S-methyltransferase	Homo sapiens	23-51
33738684-8	2022	Furthermore, hair Se levels were positively related with triglycerides/TG levels (p < 0.05) but not body mass index/BMI, total cholesterol/TC, and low-density lipoprotein cholesterol/LDL, implicating Se supplementation for Se sufficiency baseline in elderly population in Beijing likely posed health risk, especially on TG because of excessive Se oxidation stress.	Thioguanine	320-322	squalene epoxidase	Homo sapiens	18-20
33738684-8	2022	Furthermore, hair Se levels were positively related with triglycerides/TG levels (p < 0.05) but not body mass index/BMI, total cholesterol/TC, and low-density lipoprotein cholesterol/LDL, implicating Se supplementation for Se sufficiency baseline in elderly population in Beijing likely posed health risk, especially on TG because of excessive Se oxidation stress.	Thioguanine	71-73	squalene epoxidase	Homo sapiens	18-20
33714975-3	2021	6-TG is metabolized by thiopurine methyltransferase (TPMT) which underlies clinically relevant genetic polymorphism.	Thioguanine	0-4	thiopurine S-methyltransferase	Homo sapiens	53-57
33539326-9	2021	Stimulating autophagic flux via Tat-beclin 1 peptide or torin 2, promotes autophagic degradation of mutant myocilin and reduces elevated IOP in Tg-MYOCY437H mice.	Thioguanine	144-146	tyrosine aminotransferase	Mus musculus	32-35
33706732-9	2021	The TG, beta-trophin, ES level in PCOS patients with insulin resistance (IR) were significantly higher than that of those without IR (all p < 0.05).	Thioguanine	4-6	insulin	Homo sapiens	53-60
33539326-9	2021	Stimulating autophagic flux via Tat-beclin 1 peptide or torin 2, promotes autophagic degradation of mutant myocilin and reduces elevated IOP in Tg-MYOCY437H mice.	Thioguanine	144-146	beclin 1, autophagy related	Mus musculus	36-44
33539326-9	2021	Stimulating autophagic flux via Tat-beclin 1 peptide or torin 2, promotes autophagic degradation of mutant myocilin and reduces elevated IOP in Tg-MYOCY437H mice.	Thioguanine	144-146	myocilin	Mus musculus	107-115
33063676-4	2021	The DNA-TG level was compared with erythrocyte TG nucleotide (RBC-TGN) level in relation to the TPMT and NUDT15 genotypes, which affect thiopurine metabolism, using Spearman"s rank test and repeated measure ANOVA.	Thioguanine	8-10	thiopurine S-methyltransferase	Homo sapiens	96-100
33063676-4	2021	The DNA-TG level was compared with erythrocyte TG nucleotide (RBC-TGN) level in relation to the TPMT and NUDT15 genotypes, which affect thiopurine metabolism, using Spearman"s rank test and repeated measure ANOVA.	Thioguanine	8-10	nudix hydrolase 15	Homo sapiens	105-111
33591966-3	2021	Here, we show that Lzp deletion inhibited very low-density lipoprotein (VLDL) secretion, leading to hepatic TG accumulation and lower serum TG levels in mice.	Thioguanine	108-110	oncoprotein induced transcript 3	Mus musculus	19-22
33458873-8	2021	The correlation coefficient between Lp-PLA2 and lipoprotein was the highest on the levels of sdLDL (r = 0.555, p < 0.001), followed by non-HDL, LDL, TC, and TG.	Thioguanine	157-159	phospholipase A2 group VII	Homo sapiens	36-43
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	fibronectin 1	Homo sapiens	19-22
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	filamin A	Homo sapiens	24-28
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	filamin B	Homo sapiens	30-34
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	vinculin	Homo sapiens	36-39
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	gelsolin	Homo sapiens	41-44
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	myosin heavy chain 10	Homo sapiens	46-51
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	actinin alpha 4	Homo sapiens	53-58
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	kinase insert domain receptor	Homo sapiens	60-63
33470407-9	2021	The hub genes were FN1, FLNA, FLNB, VCL, GSN, MYH10, ACTN4, KDR and EREG, and they were all downregulated after 6-TG treatment.	Thioguanine	112-116	epiregulin	Homo sapiens	68-72
33470407-13	2021	We showed that PAX8-AS1 is the main lncRNA affected by 6-TG and that PAX8-AS1 regulates the hub genes in tumor pathways by competitively binding with miR-16-5p and miR-335-5p.	Thioguanine	55-59	paired box 8	Homo sapiens	15-19
33470407-13	2021	We showed that PAX8-AS1 is the main lncRNA affected by 6-TG and that PAX8-AS1 regulates the hub genes in tumor pathways by competitively binding with miR-16-5p and miR-335-5p.	Thioguanine	55-59	prostaglandin D2 receptor	Homo sapiens	20-23
33470407-13	2021	We showed that PAX8-AS1 is the main lncRNA affected by 6-TG and that PAX8-AS1 regulates the hub genes in tumor pathways by competitively binding with miR-16-5p and miR-335-5p.	Thioguanine	55-59	prostaglandin D2 receptor	Homo sapiens	74-77
33470407-13	2021	We showed that PAX8-AS1 is the main lncRNA affected by 6-TG and that PAX8-AS1 regulates the hub genes in tumor pathways by competitively binding with miR-16-5p and miR-335-5p.	Thioguanine	55-59	microRNA 335	Homo sapiens	164-171
33591966-3	2021	Here, we show that Lzp deletion inhibited very low-density lipoprotein (VLDL) secretion, leading to hepatic TG accumulation and lower serum TG levels in mice.	Thioguanine	108-110	CD320 antigen	Mus musculus	72-76
33539318-11	2021	The TG therapy showed a better CAS response than the iv.MP (91.5% vs 70.9% improved, P < 0.05), and up to 91.2% of patients were inactive.	Thioguanine	4-6	BCAR1 scaffold protein, Cas family member	Homo sapiens	31-34
33556943-8	2021	GTPCH I reduction contributes to aging-associated endothelial dysfunction, which can be retarded by Tg-GCH.	Thioguanine	100-102	GTP cyclohydrolase 1	Mus musculus	0-7
33273998-5	2020	Additionally, through its antioxidant activity, Taurisolo  modulated cell proliferation via ERK activation in THG-H9c2.	Thioguanine	110-113	Eph receptor B1	Rattus norvegicus	92-95
32889033-6	2021	RESULTS: The results showed that TG disturbed many metabolites and metabolic pathways such as oxidative stress (choline, O-phosphocholine, betaine and ascorbate), energy metabolism in mitochondria (glucose, lactate, succinate, fumarate, 3-hydroxybutyrate and alanine), mitochondrial apoptosis markers (Bax and Bcl-2) and amino acids metabolisms (arginine, branched-chain amino acids, taurine and myo-inositol).	Thioguanine	33-35	BCL2 associated X, apoptosis regulator	Rattus norvegicus	302-305
32889033-6	2021	RESULTS: The results showed that TG disturbed many metabolites and metabolic pathways such as oxidative stress (choline, O-phosphocholine, betaine and ascorbate), energy metabolism in mitochondria (glucose, lactate, succinate, fumarate, 3-hydroxybutyrate and alanine), mitochondrial apoptosis markers (Bax and Bcl-2) and amino acids metabolisms (arginine, branched-chain amino acids, taurine and myo-inositol).	Thioguanine	33-35	BCL2, apoptosis regulator	Rattus norvegicus	310-315
33464700-6	2021	Herp knockout reduced the liver/body weight ratio of mice fed with HFD with the decreased serum levels of TG, TC, HDL, LDL, GGT, Hcy, ALT, and AST.	Thioguanine	106-108	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	Mus musculus	0-4
32886944-9	2021	This meta-analysis demonstrated that 447X carriers and H allele in LPL gene associated with low risk of T2DM, which may due to in part to the change of serum level of TC, TG, LDL, and HDL.	Thioguanine	171-173	lipoprotein lipase	Homo sapiens	67-70
33282902-9	2020	In addition, rIL6 treatment led to TG accumulation accompanied by the upregulation of SCD1 in HepG2 cell lines.	Thioguanine	35-37	interleukin 6	Rattus norvegicus	13-17
33488667-9	2020	Finally, we showed that the results of the in vitro DNA cleavage assay with the wild type and mutants LbCpf1 corroborate with the selection of 6TG resistant cells associated to the genomic disruption of hprt gene.	Thioguanine	143-146	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	203-207
32896023-7	2021	Significant correlations between NFL and insulin, TC, HDL-C, TG, VLDL-C, and BMI were found.	Thioguanine	61-63	neurofilament light chain	Homo sapiens	33-36
33058914-8	2021	The miR-122/30c ratio at 2 h was positively correlated with CM particle size, and with TG, MTTP and Apo B-48 levels at 4th hour.	Thioguanine	87-89	microRNA 122	Homo sapiens	4-11
33058914-11	2021	The miR122/30c ratio exhibited good association with MTTP, Apo B-48 and TG levels, and with CM particle size, and may be a reliable marker for evaluating postprandial lipemia.	Thioguanine	72-74	microRNA 122	Homo sapiens	4-10
33273703-8	2020	On linear regression, there was significant association between percent change in ALT and AST with TG reduction after treatment (p = 0.024 and 0.037 respectively).We conclude that Saroglitazar leads to significant improvement in transaminases, LSM, and CAP in NAFLD patients with DD.	Thioguanine	99-101	solute carrier family 17 member 5	Homo sapiens	90-93
33177279-10	2020	One of the latter was Ces1d, which is known to regulate intracellular TG metabolism.	Thioguanine	70-72	carboxylesterase 1D	Mus musculus	22-27
33094788-5	2020	Lactis F1-7 (F1-7) reduced TG, TC and LDL and increased HDL.	Thioguanine	27-29	coagulation factor V	Mus musculus	7-11
33094788-5	2020	Lactis F1-7 (F1-7) reduced TG, TC and LDL and increased HDL.	Thioguanine	27-29	coagulation factor V	Mus musculus	13-17
33273998-6	2020	Furthermore, Taurisolo  was able to induce autophagic process via increasing the expression of LC3II, a protein marker involved in formation of autophagosome and ex novo synthesis of sphingomyelin, ceramides, and their metabolites both in HG- and THG-H9c2 cells.	Thioguanine	247-250	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	95-100
33171919-2	2020	In our case, we studied the effect on Tg of platy mica and an interfacial modifier with p-phenylen-bis-maleamic acid (pPBMA) grafted groups onto atactic polypropylene (aPP-pPBMA).	Thioguanine	38-40	MHC class I polypeptide-related sequence A	Homo sapiens	50-54
32372428-7	2020	In the univariate analysis, the TPMT genotype was associated with 6-thioguanine level (P < 0.05), although the significance of this did not remain in multivariate analysis (P = 0.07).	Thioguanine	66-79	thiopurine S-methyltransferase	Homo sapiens	32-36
33194583-0	2020	Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K-AKT Pathway.	Thioguanine	0-11	AKT serine/threonine kinase 1	Homo sapiens	82-85
32941836-2	2020	Cholesteryl ester transfer protein (CETP) is responsible for exchange of neutral lipids, such as cholesteryl ester and TG, between plasma high density lipoprotein (HDL) particles and Apolipoprotein B-100 (ApoB-100) containing lipoprotein particles.	Thioguanine	119-121	cholesteryl ester transfer protein	Homo sapiens	0-34
32941836-2	2020	Cholesteryl ester transfer protein (CETP) is responsible for exchange of neutral lipids, such as cholesteryl ester and TG, between plasma high density lipoprotein (HDL) particles and Apolipoprotein B-100 (ApoB-100) containing lipoprotein particles.	Thioguanine	119-121	cholesteryl ester transfer protein	Homo sapiens	36-40
32916555-11	2020	CONCLUSION: The Tg/Glu ratio can be used as a reliable surrogate index to screen for risk of insulin resistance in lean, normoglycaemic males from Southern India.	Thioguanine	16-18	insulin	Homo sapiens	93-100
33194583-6	2020	Our results indicated that 6-TG inhibited cell proliferation and tumor cell progression by suppressing PI3K-AKT pathway via downregulating the DNA methylation level of PTEN.	Thioguanine	27-31	AKT serine/threonine kinase 1	Homo sapiens	108-111
33194583-6	2020	Our results indicated that 6-TG inhibited cell proliferation and tumor cell progression by suppressing PI3K-AKT pathway via downregulating the DNA methylation level of PTEN.	Thioguanine	27-31	phosphatase and tensin homolog	Homo sapiens	168-172
33194583-8	2020	These findings indicated 6-TG exerts its anti-tumor effects in vitro and in vivo through regulating the DNA methylation levels of genes involved in PI3K-AKT and apoptosis pathway.	Thioguanine	25-29	AKT serine/threonine kinase 1	Homo sapiens	153-156
33133379-12	2020	Cur combined with TG-520 also inhibited the cascade action mediated by NF-kappaB (P < 0.0001), thus inhibiting the TLR4/NF-kappaB signalling pathway (P = 0.0088, P < 0.0001), which is associated with inflammation and acts on PD-L1.	Thioguanine	18-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
33122929-2	2020	Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an indicator of insulin resistance.	Thioguanine	54-56	insulin	Homo sapiens	89-96
33063457-7	2021	RESULTS: Serum CXCL14 levels correlated positively with body mass index, waist circumference, subcutaneous and visceral fat areas, and serum ALT, UA, TC, LDL-C, TG, and C-peptide (CPR) levels.	Thioguanine	161-163	C-X-C motif chemokine ligand 14	Homo sapiens	15-21
33133379-11	2020	Cur combined with TG-520 markedly decreased the protein expression of PD-L1 (P < 0.0001), while CD4+CD25+Foxp3+ Tregs regulated by the PD-L1 signaling pathway exhibited a positive correlation with PD-L1.	Thioguanine	18-20	CD274 antigen	Mus musculus	70-75
33133379-12	2020	Cur combined with TG-520 also inhibited the cascade action mediated by NF-kappaB (P < 0.0001), thus inhibiting the TLR4/NF-kappaB signalling pathway (P = 0.0088, P < 0.0001), which is associated with inflammation and acts on PD-L1.	Thioguanine	18-20	CD274 antigen	Mus musculus	225-230
33133379-12	2020	Cur combined with TG-520 also inhibited the cascade action mediated by NF-kappaB (P < 0.0001), thus inhibiting the TLR4/NF-kappaB signalling pathway (P = 0.0088, P < 0.0001), which is associated with inflammation and acts on PD-L1.	Thioguanine	18-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
33133379-12	2020	Cur combined with TG-520 also inhibited the cascade action mediated by NF-kappaB (P < 0.0001), thus inhibiting the TLR4/NF-kappaB signalling pathway (P = 0.0088, P < 0.0001), which is associated with inflammation and acts on PD-L1.	Thioguanine	18-20	toll-like receptor 4	Mus musculus	115-119
32777581-7	2020	Among the evaluated genetic variants, SNP rs2245803 in the MMP20 gene in a homozygous form in a recessive model was associated with MIH development (OR, 2.796; 95 %CI, 1.075 - 4.783; p = 0.0496) with the genotype distribution of TT(3), TG(6) or GG(13) in children with MIH and distribution of TT(18), TG(42) or GG(31) in children without MIH.	Thioguanine	236-238	matrix metallopeptidase 20	Homo sapiens	59-64
32526422-4	2020	The total Hg (THg) concentration of surface water in the KRB ranged from 0.64 to 32.96 ng L-1 with an average of 5.83 +- 6.19 ng L-1 and decreased in the order of post-monsoon (8.79 +- 7.32 ng L-1) > monsoon (6.68 +- 6.12 ng L-1) > pre-monsoon (2.18 +- 1.29 ng L-1).	Thioguanine	14-17	L1 cell adhesion molecule	Homo sapiens	90-93
32777581-7	2020	Among the evaluated genetic variants, SNP rs2245803 in the MMP20 gene in a homozygous form in a recessive model was associated with MIH development (OR, 2.796; 95 %CI, 1.075 - 4.783; p = 0.0496) with the genotype distribution of TT(3), TG(6) or GG(13) in children with MIH and distribution of TT(18), TG(42) or GG(31) in children without MIH.	Thioguanine	301-303	matrix metallopeptidase 20	Homo sapiens	59-64
32198668-7	2020	TG-6, TG-7, TG-10, TG-11, and TPO-6 were immunodominant in GD patients compared with HT patients (TG-6: 38.5 vs. 8%, P = 0.034; TG-7, TG-10, TG-11, and TPO-6: 23.1 vs. 0%, P = 0.034).	Thioguanine	0-2	transglutaminase 6	Homo sapiens	98-102
33155226-7	2020	RESULTS: In univariate analysis, cystatin C levels were significantly associated with TG/HDL-c ratio (OR=1.813; 95% CI: 1.190-2.757, p=0.005).	Thioguanine	86-88	cystatin C	Homo sapiens	33-43
33155226-11	2020	Longitudinal studies are needed to confirm the causal relationship between cystatin C and TG/HDL-c ratio and to further explore its diagnostic and therapeutic potential in dyslipidemia and insulin resistance in young population.	Thioguanine	90-92	cystatin C	Homo sapiens	75-85
33062710-7	2020	The most reduced eGFR group shared the least reduced BMI and LDL-C, as well as the greatest increase in TG levels.	Thioguanine	104-106	epidermal growth factor receptor	Homo sapiens	17-21
33062710-8	2020	Only TG in the follow-up, not any of the baseline data, nor obesity, blood glucose, BP, or LDL-C in the follow-up, was found to be significantly correlated with the most reduced eGFR.	Thioguanine	5-7	epidermal growth factor receptor	Homo sapiens	178-182
33533417-2	2020	Electrochemical behavior of 6-thioguanine (6-TG) has been studied using a carbon paste electrode modified by 1-ethyl-3-methylimidazolium tetrafluoroborate (ionic liquid) (1E3MIBF4) and CuO nanoparticles (CuO/1E3MIBF4/ CPE).	Thioguanine	28-41	carboxypeptidase E	Homo sapiens	218-221
33533417-2	2020	Electrochemical behavior of 6-thioguanine (6-TG) has been studied using a carbon paste electrode modified by 1-ethyl-3-methylimidazolium tetrafluoroborate (ionic liquid) (1E3MIBF4) and CuO nanoparticles (CuO/1E3MIBF4/ CPE).	Thioguanine	43-47	carboxypeptidase E	Homo sapiens	218-221
33073943-8	2020	The serum miR-2467 level of GDM pregnant women was positively correlated with the levels of TC, TG, LDL-C, FPG, HbA1c, and HOMA-IR.	Thioguanine	96-98	microRNA 2467	Homo sapiens	10-18
32979999-1	2020	The impact of a hydroelectric run-of-river (RoR) dam construction on the dynamics of total mercury (THg) and methylmercury (MeHg) is of interest to the environment and health of human and wild life.	Thioguanine	100-103	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	44-47
32559505-8	2020	(4) The level of serum RBP4 was positively correlated with TC, TG, and LDL-C (r = 0.350, 0.207, 0.268; P < 0.001, P = 0.001, P < 0.001), but not with other blood lipid indexes.	Thioguanine	63-65	retinol binding protein 4	Homo sapiens	23-27
32955223-8	2020	The model of inheritance for the MC4R polymorphism had a significant effect on TG (p = 0.039) and non-HDL (p = 0.05) levels.	Thioguanine	79-81	melanocortin 4 receptor	Homo sapiens	33-37
33533417-5	2020	The diffusion coefficient of 6-TG on the CuO/1E3MIBF4/CPE was found to be 1.54 x 10?5 cm2s?1 .The CuO/1E3MIBF4/ CPE was successfully applied for the determination of 6-TG in real samples.	Thioguanine	29-33	carboxypeptidase E	Homo sapiens	54-57
33533417-5	2020	The diffusion coefficient of 6-TG on the CuO/1E3MIBF4/CPE was found to be 1.54 x 10?5 cm2s?1 .The CuO/1E3MIBF4/ CPE was successfully applied for the determination of 6-TG in real samples.	Thioguanine	29-33	carboxypeptidase E	Homo sapiens	112-115
33533417-5	2020	The diffusion coefficient of 6-TG on the CuO/1E3MIBF4/CPE was found to be 1.54 x 10?5 cm2s?1 .The CuO/1E3MIBF4/ CPE was successfully applied for the determination of 6-TG in real samples.	Thioguanine	166-170	carboxypeptidase E	Homo sapiens	54-57
33533417-5	2020	The diffusion coefficient of 6-TG on the CuO/1E3MIBF4/CPE was found to be 1.54 x 10?5 cm2s?1 .The CuO/1E3MIBF4/ CPE was successfully applied for the determination of 6-TG in real samples.	Thioguanine	166-170	carboxypeptidase E	Homo sapiens	112-115
33533417-6	2020	In addition, the anodic peaks of 6-TG and fluorouracil (5-FU) in their mixture can be well separated using CuO/1E3MIBF4/CPE and simultaneous determination of them was studied.	Thioguanine	33-37	carboxypeptidase E	Homo sapiens	120-123
32020585-10	2020	Compared with those with a tHg <= 0 47 mug L-1 (Q1), those with a tHg > 1 74 mug L-1 (Q4) had nearly double the odds of NMSC (OR 1 79, 95% CI 1 19-2 71; Ptrend = 0 004).	Thioguanine	66-69	immunoglobulin kappa variable 1-16	Homo sapiens	81-84
32587096-6	2020	The K m values for OATP1B1-mediated uptake were low for EtioG (6.2 microM) as compared with AG, TG, and DHTG (46.2, 56.7, and 71.3 microM, respectively), whereas the K m value for OATP1B3-mediated uptake for EtioG, AG, DHTG, and TG were 19.8, 29.3, 69.6, and 110.4 microM, respectively.	Thioguanine	96-98	solute carrier organic anion transporter family member 1B1	Homo sapiens	19-26
32782516-12	2020	After modeling, the contents of serum BUN, SCR, UA and beta2-MG in TG were significantly lower than those in MG (P<0.05).	Thioguanine	67-69	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	55-60
32332924-1	2020	The triglyceride to high-density lipoprotein-cholesterol (TG/HDL-C) ratio is considered a simple surrogate of insulin resistance.	Thioguanine	58-60	insulin	Homo sapiens	110-117
32470452-8	2020	Modified TG-8, termed LTG-6, exerted the great binding affinity for human serum albumin and the enhanced rational controlled-release of TG-8 in vitro.	Thioguanine	9-11	albumin	Mus musculus	74-87
32470452-8	2020	Modified TG-8, termed LTG-6, exerted the great binding affinity for human serum albumin and the enhanced rational controlled-release of TG-8 in vitro.	Thioguanine	23-25	albumin	Mus musculus	74-87
32587096-6	2020	The K m values for OATP1B1-mediated uptake were low for EtioG (6.2 microM) as compared with AG, TG, and DHTG (46.2, 56.7, and 71.3 microM, respectively), whereas the K m value for OATP1B3-mediated uptake for EtioG, AG, DHTG, and TG were 19.8, 29.3, 69.6, and 110.4 microM, respectively.	Thioguanine	106-108	solute carrier organic anion transporter family member 1B1	Homo sapiens	19-26
32587096-8	2020	When adjusted for the transporter abundance in human livers, EtioG and DHTG were predicted to be transported by both OATP1B1 and OATP1B3, whereas TG and AG were preferentially (>68%) transported by OATP1B3.	Thioguanine	73-75	solute carrier organic anion transporter family member 1B1	Homo sapiens	117-124
32587096-8	2020	When adjusted for the transporter abundance in human livers, EtioG and DHTG were predicted to be transported by both OATP1B1 and OATP1B3, whereas TG and AG were preferentially (>68%) transported by OATP1B3.	Thioguanine	73-75	solute carrier organic anion transporter family member 1B3	Homo sapiens	129-136
32587096-8	2020	When adjusted for the transporter abundance in human livers, EtioG and DHTG were predicted to be transported by both OATP1B1 and OATP1B3, whereas TG and AG were preferentially (>68%) transported by OATP1B3.	Thioguanine	73-75	solute carrier organic anion transporter family member 1B3	Homo sapiens	198-205
32587096-11	2020	TG and AG can be further investigated as potential biomarkers of OATP1B3 inhibition.	Thioguanine	0-2	solute carrier organic anion transporter family member 1B3	Homo sapiens	65-72
32480025-7	2020	RESULTS: The presence of minor alleles of GCLC-129 (rs17883901), GPX1-198 (rs1050450) and MT1M (rs9936741) were associated with significantly lower hair tHg levels in mothers whereas mothers with minor alleles of GSTP1-105(rs1695) and MT1M (rs2270836) have significantly higher hair tHg levels.	Thioguanine	153-156	glutamate-cysteine ligase catalytic subunit	Homo sapiens	42-46
28520351-0	2012	Thioguanine Therapy and TPMT Genotype Thioguanine is an antineoplastic agent that belongs to the drug class of thiopurines.	Thioguanine	38-49	thiopurine S-methyltransferase	Homo sapiens	24-28
28520351-3	2012	Thiopurine S-methyltransferase (TPMT) inactivates thioguanine, leaving less parent drug available to form TGNs.	Thioguanine	50-61	thiopurine S-methyltransferase	Homo sapiens	0-30
28520351-3	2012	Thiopurine S-methyltransferase (TPMT) inactivates thioguanine, leaving less parent drug available to form TGNs.	Thioguanine	50-61	thiopurine S-methyltransferase	Homo sapiens	32-36
28520351-5	2012	However, patients who carry two nonfunctional TPMT alleles universally experience life-threatening myelosuppression when treated with thioguanine, due to high levels of TGNs.	Thioguanine	134-145	thiopurine S-methyltransferase	Homo sapiens	46-50
28520351-6	2012	Patients who carry one nonfunctional TPMT allele may also be unable to tolerate conventional doses of thioguanine (2, 3).	Thioguanine	102-113	thiopurine S-methyltransferase	Homo sapiens	37-41
28520351-7	2012	The FDA-approved drug label for thioguanine states that there are individuals with an inherited deficiency of the thiopurine methyltransferase (TPMT) enzyme who may be unusually sensitive to the myelosuppressive effects of thioguanine and prone to developing rapid bone marrow suppression following treatment initiation.	Thioguanine	32-43	thiopurine S-methyltransferase	Homo sapiens	114-142
28520351-7	2012	The FDA-approved drug label for thioguanine states that there are individuals with an inherited deficiency of the thiopurine methyltransferase (TPMT) enzyme who may be unusually sensitive to the myelosuppressive effects of thioguanine and prone to developing rapid bone marrow suppression following treatment initiation.	Thioguanine	32-43	thiopurine S-methyltransferase	Homo sapiens	144-148
28520351-7	2012	The FDA-approved drug label for thioguanine states that there are individuals with an inherited deficiency of the thiopurine methyltransferase (TPMT) enzyme who may be unusually sensitive to the myelosuppressive effects of thioguanine and prone to developing rapid bone marrow suppression following treatment initiation.	Thioguanine	223-234	thiopurine S-methyltransferase	Homo sapiens	114-142
28520351-7	2012	The FDA-approved drug label for thioguanine states that there are individuals with an inherited deficiency of the thiopurine methyltransferase (TPMT) enzyme who may be unusually sensitive to the myelosuppressive effects of thioguanine and prone to developing rapid bone marrow suppression following treatment initiation.	Thioguanine	223-234	thiopurine S-methyltransferase	Homo sapiens	144-148
28520351-10	2012	The Clinical Pharmacogenetics Implementation Consortium (CPIC) has published recommendations for TPMT genotype-based thioguanine dosing.	Thioguanine	117-128	thiopurine S-methyltransferase	Homo sapiens	97-101
32827393-5	2020	However, all these patients had the NUDT15 415C>T variant that has been reported to explain serious toxicity to thioguanine in Asian patients.	Thioguanine	112-123	nudix hydrolase 15	Homo sapiens	36-42
32243572-10	2020	AGS7-derived iPSCs were also more sensitive to thioguanine, while AGS2 and AT iPSCs were less sensitive to this medication than the BJ-iPSC.	Thioguanine	47-58	interferon induced with helicase C domain 1	Homo sapiens	0-4
32480025-7	2020	RESULTS: The presence of minor alleles of GCLC-129 (rs17883901), GPX1-198 (rs1050450) and MT1M (rs9936741) were associated with significantly lower hair tHg levels in mothers whereas mothers with minor alleles of GSTP1-105(rs1695) and MT1M (rs2270836) have significantly higher hair tHg levels.	Thioguanine	153-156	metallothionein 1M	Homo sapiens	90-94
32492461-6	2020	These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity.	Thioguanine	45-47	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	102-107
32480025-7	2020	RESULTS: The presence of minor alleles of GCLC-129 (rs17883901), GPX1-198 (rs1050450) and MT1M (rs9936741) were associated with significantly lower hair tHg levels in mothers whereas mothers with minor alleles of GSTP1-105(rs1695) and MT1M (rs2270836) have significantly higher hair tHg levels.	Thioguanine	283-286	glutamate-cysteine ligase catalytic subunit	Homo sapiens	42-46
32492461-6	2020	These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity.	Thioguanine	45-47	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	109-115
32480025-7	2020	RESULTS: The presence of minor alleles of GCLC-129 (rs17883901), GPX1-198 (rs1050450) and MT1M (rs9936741) were associated with significantly lower hair tHg levels in mothers whereas mothers with minor alleles of GSTP1-105(rs1695) and MT1M (rs2270836) have significantly higher hair tHg levels.	Thioguanine	283-286	metallothionein 1M	Homo sapiens	90-94
32492461-6	2020	These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity.	Thioguanine	45-47	nuclear receptor subfamily 1, group I, member 2	Mus musculus	117-120
32492461-6	2020	These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity.	Thioguanine	45-47	nuclear receptor subfamily 1, group H, member 4	Mus musculus	125-128
32492461-6	2020	These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity.	Thioguanine	45-47	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	234-240
32492461-6	2020	These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity.	Thioguanine	45-47	nuclear receptor subfamily 1, group I, member 2	Mus musculus	242-245
32234597-15	2020	TG-n2 and TG alleviated the decrease of podocin protein expression and morphological injury of podocyte as screened by Western Blot and electron microscopic analysis.	Thioguanine	10-12	NPHS2 stomatin family member, podocin	Rattus norvegicus	40-47
32492461-6	2020	These data suggested that rifampin increases TG and TC levels in the liver may be related to activate HMGCR, CYP7A1, PXR and FXR, theses toxic actions of rifampin were alleviated by pyrazinamide may be due to inhibite the activity of CYP7A1, PXR and FAS, and increasing the LPL protein expression and activity.	Thioguanine	45-47	lipoprotein lipase	Mus musculus	274-277
32436749-5	2020	Importantly, IRE1alpha inhibition prevented palmitate-triggered cell death and TG overproduction, suggesting mTORC1-IRE1alpha pathway is mechanistically implicated in palmitate lipotoxicity.	Thioguanine	79-81	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	13-22
32436749-5	2020	Importantly, IRE1alpha inhibition prevented palmitate-triggered cell death and TG overproduction, suggesting mTORC1-IRE1alpha pathway is mechanistically implicated in palmitate lipotoxicity.	Thioguanine	79-81	CREB regulated transcription coactivator 1	Mus musculus	109-115
32379931-10	2020	CONCLUSIONS: pdFVIII/VWF showed a non-additive effect on TG when combined in vitro with emicizumab.	Thioguanine	57-59	von Willebrand factor	Homo sapiens	13-24
32748596-11	2020	The expression of PLIN1 mRNA and protein in the adipocytes was significantly inhibited (P<0.05); glycerol levels increased significantly (0.098 4+-0.007 6), TG levels decreased significantly (0.031 0+-0.005 3); mRNA and protein expression of HSL and ATGL increased (P<0.05); PPARgamma and Fsp27 expression unchanged in adipocytes.	Thioguanine	157-159	perilipin 1	Homo sapiens	18-23
32234597-14	2020	RESULTS: TG-n2 and TG intervention ameliorated renal function as assessed by the levels of 24-h proteinuria, Cr, BUN, TC, TG, ALB and LDL-c.	Thioguanine	9-11	albumin	Rattus norvegicus	126-129
32234597-14	2020	RESULTS: TG-n2 and TG intervention ameliorated renal function as assessed by the levels of 24-h proteinuria, Cr, BUN, TC, TG, ALB and LDL-c.	Thioguanine	19-21	albumin	Rattus norvegicus	126-129
32234597-14	2020	RESULTS: TG-n2 and TG intervention ameliorated renal function as assessed by the levels of 24-h proteinuria, Cr, BUN, TC, TG, ALB and LDL-c.	Thioguanine	19-21	albumin	Rattus norvegicus	126-129
32234597-15	2020	TG-n2 and TG alleviated the decrease of podocin protein expression and morphological injury of podocyte as screened by Western Blot and electron microscopic analysis.	Thioguanine	0-2	NPHS2 stomatin family member, podocin	Rattus norvegicus	40-47
32234597-17	2020	TG-n2 and TG could significantly inhibit the apoptosis and activity of caspase-3 in kidney tissues as examined by fluorescence microscopic analysis and reagent.	Thioguanine	0-2	caspase 3	Rattus norvegicus	71-80
32196929-3	2020	The aim of this study was to determine whether TG in the presence of thrombomodulin (TM) provides more useful information about coagulation potential, in comparison to the PT.	Thioguanine	47-49	thrombomodulin	Homo sapiens	69-83
32684941-6	2020	Results: There was a significant non-linear relationship between lipid profile (TC, TG, HDL-C, LDL-C) and hs-CRP (P < 0.05).	Thioguanine	84-86	C-reactive protein	Homo sapiens	109-112
32684941-8	2020	Compared with medium levels of lipids group, pregnant women with higher levels of TC or TG have higher levels of hs-CRP, and pregnant women with lower levels of TC, HDL-C or LDL-C also have higher levels of hs-CRP in the vitamin D deficient group, and there was a significant correlation between low levels of TG and decreased hs-CRP (adjusted beta for TG: -0.063, 95%CI: - 0.120,-0.007) in the non-vitamin D deficient group.	Thioguanine	88-90	C-reactive protein	Homo sapiens	116-119
32637945-0	2020	6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities.	Thioguanine	0-13	plpro	None	61-66
32637945-3	2020	We show here that 6-Thioguanine (6-TG) inhibits SARS-CoV-2 PLpro-catalyzed viral polyprotein cleavage and ISG15 deconjugation in cells and inhibits replication of SARS-CoV-2 in Vero-E6 cells and Calu3 cells at submicromolar levels.	Thioguanine	18-31	ISG15 ubiquitin like modifier	Homo sapiens	106-111
32637945-3	2020	We show here that 6-Thioguanine (6-TG) inhibits SARS-CoV-2 PLpro-catalyzed viral polyprotein cleavage and ISG15 deconjugation in cells and inhibits replication of SARS-CoV-2 in Vero-E6 cells and Calu3 cells at submicromolar levels.	Thioguanine	33-37	ISG15 ubiquitin like modifier	Homo sapiens	106-111
32259664-12	2020	TG treatment significantly relieved behavioral and pathological symptoms of MPTP-induced PD mouse models with a potential mechanism of alleviating ALOX15-induced lipid peroxidation.	Thioguanine	0-2	arachidonate 15-lipoxygenase	Mus musculus	147-153
32429902-10	2020	Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A.	Thioguanine	56-58	alpha 2-HS glycoprotein	Homo sapiens	6-14
32685557-6	2020	Results: The overall ORs reflected a positive correlation between the ADIPOQ rs2241766 polymorphism and susceptibility to DKD in the GG vs. TT and GG vs. TT+TG comparisons (OR = 1.51, 95%CI = 1.16 - 1.95; OR = 1.43, 95%CI = 1.11 - 1.85).	Thioguanine	157-159	adiponectin, C1Q and collagen domain containing	Homo sapiens	70-76
27809435-1	2000	Genetic background, gestational conditions and nutrition in infancy and childhood contribute to HTG associated with formation of an atherogenic dyslipidemia consisting of high TG, low HDL-cholesterol, increased LDL particle number or apolipoprotein B and smaller LDL size and density.	Thioguanine	97-99	apolipoprotein B	Homo sapiens	234-250
30270690-1	2020	Objective: We investigated the association between the triglycerides to high-density lipoprotein cholesterol (TG/HDL) ratio and low testosterone and sex hormone-binding globulin (SHBG) levels in middle-aged and elderly men.Methods: This cross-sectional study included 1055 men aged >=45 years who underwent a medical examination.	Thioguanine	110-112	sex hormone binding globulin	Homo sapiens	179-183
32169758-3	2020	Contrary to wild-type, activation of S286L-mutant alpha4beta2-nAChR (loss-of-function) in the RTN relatively enhanced glutamatergic transmission in thalamic hyperdirect pathway of S286L-TG via impaired GABAergic inhibition in intra-thalamic (RTN-MoTN) pathway.	Thioguanine	186-188	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	62-67
31427180-4	2020	RESULTS: The obtained data demonstrated that both DM1 and DM2 patients were characterized by significantly elevated HbA1c, FBG, TC, LDL-C, VLDL-C, and TG levels as compared to controls.	Thioguanine	151-153	immunoglobulin heavy diversity 1-7	Homo sapiens	50-53
31427180-4	2020	RESULTS: The obtained data demonstrated that both DM1 and DM2 patients were characterized by significantly elevated HbA1c, FBG, TC, LDL-C, VLDL-C, and TG levels as compared to controls.	Thioguanine	151-153	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	58-61
32572893-13	2020	The frequency of CC+CA in the dominant model of IRAK1 rs3027898 and that of TG+GG in the recessive model of miR-146a rs7702165 in disease group were lower than those in control group.	Thioguanine	76-78	microRNA 146a	Homo sapiens	108-116
32379116-8	2020	RESULTS: Serum high-sensitivity CRP >1.0 mg/L was significantly associated with IAC (OR, 2.47 [95% CI, 1.65 to 3.70]) after adjusting for diabetes, fasting glucose level, HbA1c, dyslipidemia, TG/HDL >3.5, and thyroid-stimulating hormone (p <= 0.031).	Thioguanine	192-194	C-reactive protein	Homo sapiens	32-35
32443400-2	2020	Cx43 expression in the thalamic plasma membrane fraction of S286L-TG was upregulated compared with that of wild-type.	Thioguanine	66-68	gap junction protein alpha 1	Homo sapiens	0-4
32393179-3	2020	Insulin resistance, the exposure, was defined by quartiles for three indexes: 1) the homeostatic model assessment of insulin resistance (HOMA-IR), 2) the triglyceride and glucose index (TyG), and 3) the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C).	Thioguanine	263-265	insulin	Homo sapiens	0-7
32477263-5	2020	In the PCOS patients, serum PRL was significantly and positively correlated with FPG, serum TSH and serum FT4, and significantly and negatively correlated with LH, LH/FSH, TC, TG, LDL-C, AST, ALT, gamma-GGT, FT3, and FT3/FT4 (p < 0.05 or 0.01).	Thioguanine	176-178	prolactin	Homo sapiens	28-31
32346607-7	2020	A 181-compound library screening showed that SLP-2KO produced resistance to JAK2 inhibitors (NVP-BSK805 and TG-101348) and a PIM1 inhibitor (SGI-1776), revealing that the JAK2-STAT3-PIM1 oncogenic pathway was potentially controlled by SLP-2 in CRC.	Thioguanine	108-110	stomatin like 2	Homo sapiens	45-50
32354894-9	2020	Phosphorylation of beta-catenin was enhanced by continuous exposure to TG compared with intermittent exposure.	Thioguanine	71-73	catenin beta 1	Rattus norvegicus	19-31
32299444-5	2020	The effect of miR-30b-5p on the lipid deposition in Huh-7 cells was tested by oil red O staining and TG concentrations measurement.	Thioguanine	101-103	microRNA 30b	Homo sapiens	14-21
32300663-5	2020	Insulin-like growth factor 1 (IGF-1) augmented the intracellular level of TG in sebocytes and preadipocytes.	Thioguanine	74-76	insulin like growth factor 1	Homo sapiens	0-28
32300663-5	2020	Insulin-like growth factor 1 (IGF-1) augmented the intracellular level of TG in sebocytes and preadipocytes.	Thioguanine	74-76	insulin like growth factor 1	Homo sapiens	30-35
32300663-8	2020	Moreover, insulin-augmented TG production in sebocytes was enhanced by IGF-1 and 5alpha-DHT, while diminished by 1,25(OH2)D3.	Thioguanine	28-30	insulin	Homo sapiens	10-17
32300663-8	2020	Moreover, insulin-augmented TG production in sebocytes was enhanced by IGF-1 and 5alpha-DHT, while diminished by 1,25(OH2)D3.	Thioguanine	28-30	insulin like growth factor 1	Homo sapiens	71-76
32119557-7	2020	The highest Tg was found to be at CAR-ASP 1:1.46 and CAR-GLU 1:1.43 mathematically.	Thioguanine	12-14	CXADR pseudogene 1	Homo sapiens	34-43
32119557-7	2020	The highest Tg was found to be at CAR-ASP 1:1.46 and CAR-GLU 1:1.43 mathematically.	Thioguanine	12-14	CXADR pseudogene 1	Homo sapiens	53-62
31541471-11	2020	H&E and IHC staining exhibited attenuated inflammation and TLR4 expression in the 335-Tg-EP group.	Thioguanine	86-88	toll-like receptor 4	Mus musculus	59-63
31541471-12	2020	Furthermore, reduced expressions of IL-1beta, IL-6, TNF-alpha, and TLR4 were also detected in the 335-Tg-EP group.	Thioguanine	102-104	interleukin 1 alpha	Mus musculus	36-44
31541471-12	2020	Furthermore, reduced expressions of IL-1beta, IL-6, TNF-alpha, and TLR4 were also detected in the 335-Tg-EP group.	Thioguanine	102-104	interleukin 6	Mus musculus	46-50
31541471-12	2020	Furthermore, reduced expressions of IL-1beta, IL-6, TNF-alpha, and TLR4 were also detected in the 335-Tg-EP group.	Thioguanine	102-104	tumor necrosis factor	Mus musculus	52-61
31541471-12	2020	Furthermore, reduced expressions of IL-1beta, IL-6, TNF-alpha, and TLR4 were also detected in the 335-Tg-EP group.	Thioguanine	102-104	toll-like receptor 4	Mus musculus	67-71
32235384-2	2020	Expression of Cx43 in the M2C plasma membrane fraction of S286L-TG was upregulated compared with wild-type rats.	Thioguanine	64-66	gap junction protein, alpha 1	Rattus norvegicus	14-18
32235384-5	2020	Upregulated Cx43 enhanced glutamatergic transmission during both resting and hyperexcitable stages in S286L-TG.	Thioguanine	108-110	gap junction protein, alpha 1	Rattus norvegicus	12-16
32004966-8	2020	Maximum THg contents in Bhs horizons coincided with the highest peaks of reactive Fe and Al compounds (PC1 and PC2) and secondary crystalline minerals (PC3) in both soils.	Thioguanine	8-11	proprotein convertase subtilisin/kexin type 1	Homo sapiens	103-106
32004966-8	2020	Maximum THg contents in Bhs horizons coincided with the highest peaks of reactive Fe and Al compounds (PC1 and PC2) and secondary crystalline minerals (PC3) in both soils.	Thioguanine	8-11	chromobox 4	Homo sapiens	111-114
32004966-8	2020	Maximum THg contents in Bhs horizons coincided with the highest peaks of reactive Fe and Al compounds (PC1 and PC2) and secondary crystalline minerals (PC3) in both soils.	Thioguanine	8-11	proprotein convertase subtilisin/kexin type 1	Homo sapiens	152-155
32392664-7	2020	RESULTS: In multivariate logistic regression, significantly increased risk of lung cancer was observed for MDM2 SNP309 in the dominant model (TG + GG vs. TT: OR, 2.13; 95% CI, 1.29 to 3.53).	Thioguanine	142-144	MDM2 proto-oncogene	Homo sapiens	107-111
32382289-11	2020	The levels of miR-126, MAPK, JNK, and ERK in the TG group were lower than those in the CG group (P < 0.05).	Thioguanine	49-51	microRNA 126	Homo sapiens	14-21
32382289-11	2020	The levels of miR-126, MAPK, JNK, and ERK in the TG group were lower than those in the CG group (P < 0.05).	Thioguanine	49-51	mitogen-activated protein kinase 8	Homo sapiens	29-32
32382289-11	2020	The levels of miR-126, MAPK, JNK, and ERK in the TG group were lower than those in the CG group (P < 0.05).	Thioguanine	49-51	mitogen-activated protein kinase 1	Homo sapiens	38-41
32299444-9	2020	Overexpressing miR-30b-5p in Huh-7 cells decreased the number and size of lipid droplets and intracellular TG concentrations in Huh-7 cells.	Thioguanine	107-109	microRNA 30b	Homo sapiens	15-22
32322735-7	2020	Following adjustment for age, gender, diet and other variables, only the association between different quartiles of PCB 138, PCB 153, PCB 118 and PCB sum and TG remained statistically significant.	Thioguanine	158-160	pyruvate carboxylase	Homo sapiens	116-119
32322735-7	2020	Following adjustment for age, gender, diet and other variables, only the association between different quartiles of PCB 138, PCB 153, PCB 118 and PCB sum and TG remained statistically significant.	Thioguanine	158-160	pyruvate carboxylase	Homo sapiens	125-128
32300663-9	2020	In preadipocytes, the insulin-augmented production of TG was decreased by IGF-1, 1,25(OH2)D3, and 5alpha-DHT.	Thioguanine	54-56	insulin	Homo sapiens	22-29
32300663-9	2020	In preadipocytes, the insulin-augmented production of TG was decreased by IGF-1, 1,25(OH2)D3, and 5alpha-DHT.	Thioguanine	54-56	insulin like growth factor 1	Homo sapiens	74-79
32346607-9	2020	Overall, our findings suggest that SLP-2 controls the JAK2-STAT3-PIM1 oncogenic pathway, offering a rationale for a novel therapeutic strategy with combined SGI-1776 and TG-101348 in CRC.	Thioguanine	170-172	stomatin like 2	Homo sapiens	35-40
32292609-11	2020	Experimental ANGPTL3 and APOC3 inhibitors each lowered TG by >50%.	Thioguanine	55-57	angiopoietin like 3	Homo sapiens	13-20
32292609-11	2020	Experimental ANGPTL3 and APOC3 inhibitors each lowered TG by >50%.	Thioguanine	55-57	apolipoprotein C3	Homo sapiens	25-30
32131838-1	2020	BACKGROUND: Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) is one of major risk factors of insulin resistance and diabetes.	Thioguanine	108-110	insulin	Homo sapiens	150-157
32171306-6	2020	RESULTS: Our results showed that TG and VLDL-C levels were significantly increased in young female SLE as compared to control, with TC, HDL-C, LDL-C, Apo A, and Apo B significantly reduced.	Thioguanine	33-35	lipoprotein(a)	Homo sapiens	150-155
32171306-6	2020	RESULTS: Our results showed that TG and VLDL-C levels were significantly increased in young female SLE as compared to control, with TC, HDL-C, LDL-C, Apo A, and Apo B significantly reduced.	Thioguanine	33-35	aminopeptidase O (putative)	Homo sapiens	150-153
32218741-10	2020	On the other hand, the increase in the SF-36 scores and in the relative levels of miR-17-92 was significantly higher in the TG group when compared with that of the CG group (P < 0.05).	Thioguanine	124-126	miR-17-92a-1 cluster host gene	Homo sapiens	82-91
32103989-0	2020	Transcriptomics Analysis of the Tumor-Inhibitory Pathways of 6-Thioguanine in MCF-7 Cells via Silencing DNMT1 Activity.	Thioguanine	61-74	DNA methyltransferase 1	Homo sapiens	104-109
32081971-11	2020	In vitro analysis revealed that CCN1 increased the intracellular TG content, the pro-inflammatory cytokines and the expression level of apoptosis-associated proteins in a steatosis model using murine primary hepatocytes.	Thioguanine	65-67	cellular communication network factor 1	Mus musculus	32-36
31916133-7	2020	After adjusting for age, sex, ALT, AST, TC, TG, HDL, LDL, FBG, and UA, FABP1 was independently correlated with BMI (*P < 0.05).	Thioguanine	44-46	fatty acid binding protein 1	Homo sapiens	71-76
32103989-8	2020	Moreover, 6-TG also induced MCF-7 cells to undergo G2/M phase cell cycle arrest and upregulated CDKN1A (p21).	Thioguanine	10-14	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-102
32103989-8	2020	Moreover, 6-TG also induced MCF-7 cells to undergo G2/M phase cell cycle arrest and upregulated CDKN1A (p21).	Thioguanine	10-14	cyclin dependent kinase inhibitor 1A	Homo sapiens	104-107
32103989-9	2020	Conclusion: Overall, our results suggest that 6-TG may induce FAS-mediated exogenous apoptosis and p21-dependent G2/M arrest by inhibiting the activity of DNMT1 in MCF-7 breast cancer cells.	Thioguanine	46-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	99-102
32103989-9	2020	Conclusion: Overall, our results suggest that 6-TG may induce FAS-mediated exogenous apoptosis and p21-dependent G2/M arrest by inhibiting the activity of DNMT1 in MCF-7 breast cancer cells.	Thioguanine	46-50	DNA methyltransferase 1	Homo sapiens	155-160
31885562-0	2019	TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance.	Thioguanine	0-2	insulin	Homo sapiens	115-122
31468699-3	2020	The present study was aimed to investigate the role of CYP2E1 in acetaminophen (APAP)- or tripterygium glycosides (TG)-induced hepatotoxicity as well as the regulation of CYP2E1 and miR-378a-3p expression by APAP or TG.	Thioguanine	115-117	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	55-61
31468699-10	2020	Our results showed that CMZ effectively restored the hepatic histopathological changes, oxidative stress biomarkers and TNF-alpha levels induced by APAP or TG.	Thioguanine	156-158	tumor necrosis factor	Rattus norvegicus	120-129
31468699-11	2020	CYP2E1 mRNA and/or protein expression levels were dramatically increased after chronic APAP or TG treatment, while this induction was significantly reversed by CMZ co-treatment.	Thioguanine	95-97	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	0-6
31468699-13	2020	These results suggested that CYP2E1 were highly induced following chronic APAP or TG treatment, which in turn play an important role in APAP- or TG-induced hepatotoxicity.	Thioguanine	82-84	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	29-35
31172823-7	2020	MIP showed a large effect size for CG (1.00) and TG (1.35), while MEP showed a moderate effect for CG (0.61) and TG (0.73); distance covered had a moderate effect size for TG (0.70).	Thioguanine	49-51	major intrinsic protein of lens fiber	Homo sapiens	0-3
31172823-7	2020	MIP showed a large effect size for CG (1.00) and TG (1.35), while MEP showed a moderate effect for CG (0.61) and TG (0.73); distance covered had a moderate effect size for TG (0.70).	Thioguanine	113-115	neurolysin	Homo sapiens	66-69
31172823-7	2020	MIP showed a large effect size for CG (1.00) and TG (1.35), while MEP showed a moderate effect for CG (0.61) and TG (0.73); distance covered had a moderate effect size for TG (0.70).	Thioguanine	113-115	neurolysin	Homo sapiens	66-69
31956875-8	2020	In serum, SSA1 reduced TG, TC, and LDL-C but increased HDL-C; SSA2 decreased TC, TG, and LDL-C but did not affect HDL-C.	Thioguanine	23-25	tripartite motif-containing 21	Mus musculus	10-14
31956875-8	2020	In serum, SSA1 reduced TG, TC, and LDL-C but increased HDL-C; SSA2 decreased TC, TG, and LDL-C but did not affect HDL-C.	Thioguanine	81-83	Ro60, Y RNA binding protein	Mus musculus	62-66
30836803-11	2020	Conversely, a FVIII inhibitory antibody reduced plasma TG in all, but especially in patients with remnant FVIII levels.	Thioguanine	55-57	coagulation factor VIII	Homo sapiens	14-19
30836803-14	2020	VWD3 platelets seem to compensate for the FVIII-associated reduction in TG by their exposure of P-selectin and phosphatidylserine.	Thioguanine	72-74	coagulation factor VIII	Homo sapiens	42-47
31464791-0	2019	Severe pancytopenia and aspergillosis caused by thioguanine in a thiopurine S-methyltransferase deficient patient: a case report.	Thioguanine	48-59	thiopurine S-methyltransferase	Homo sapiens	65-95
31464791-9	2019	Our patient developed a severe pancytopenia on thioguanine therapy, with 6-thioguanine nucleotides levels more than 10 times higher than the upper limit of the therapeutic window and was found to be a TPMT poor metabolizer (TPMT *3A/*3A).	Thioguanine	47-58	thiopurine S-methyltransferase	Homo sapiens	201-205
31464791-10	2019	This case strongly illustrates that knowledge of TPMT enzyme activity is very important in the use of all thiopurines, including thioguanine.	Thioguanine	129-140	thiopurine S-methyltransferase	Homo sapiens	49-53
31464791-11	2019	In conclusion, clinicians should be aware of the impact of TPMT deficiency on the metabolism of thioguanine and should consider performing preemptive TPMT genotyping in combination with frequent blood test monitoring when using thiopurines in general.	Thioguanine	96-107	thiopurine S-methyltransferase	Homo sapiens	59-63
30981822-6	2020	RESULTS: Fasting T2D large TGRL were mostly of hepatic origin (apoB100/apoB48 ratio: 42 +- 7) and rich in triglycerides (TG/total apoB ratio: 4.2 +- 0.5), and able to potentiate agonist-stimulated platelet aggregation (collagen: +68%, P &lt; 0.05; thrombin: +771%, P &lt; 0.05).	Thioguanine	27-29	apolipoprotein B	Homo sapiens	63-70
30981822-6	2020	RESULTS: Fasting T2D large TGRL were mostly of hepatic origin (apoB100/apoB48 ratio: 42 +- 7) and rich in triglycerides (TG/total apoB ratio: 4.2 +- 0.5), and able to potentiate agonist-stimulated platelet aggregation (collagen: +68%, P &lt; 0.05; thrombin: +771%, P &lt; 0.05).	Thioguanine	27-29	apolipoprotein B	Homo sapiens	71-77
30981822-6	2020	RESULTS: Fasting T2D large TGRL were mostly of hepatic origin (apoB100/apoB48 ratio: 42 +- 7) and rich in triglycerides (TG/total apoB ratio: 4.2 +- 0.5), and able to potentiate agonist-stimulated platelet aggregation (collagen: +68%, P &lt; 0.05; thrombin: +771%, P &lt; 0.05).	Thioguanine	27-29	apolipoprotein B	Homo sapiens	63-67
30981822-6	2020	RESULTS: Fasting T2D large TGRL were mostly of hepatic origin (apoB100/apoB48 ratio: 42 +- 7) and rich in triglycerides (TG/total apoB ratio: 4.2 +- 0.5), and able to potentiate agonist-stimulated platelet aggregation (collagen: +68%, P &lt; 0.05; thrombin: +771%, P &lt; 0.05).	Thioguanine	27-29	coagulation factor II, thrombin	Homo sapiens	248-256
31873873-10	2020	Participants with a high serum E-selectin level had higher levels of hs-CRP, FBG, TG, uric acid, BMI and lower levels of serum HDL-C (p < 0.05).	Thioguanine	82-84	selectin E	Homo sapiens	31-41
31949496-7	2020	Results: BRAF V600E mutation was detected in 75 of the 128 patients (58.6%) and was observed more frequently in cases with elevated Tg levels (Tg>1.00) at 3, 6, 12, and 18 months after treatment compared with patients without any BRAF mutations (P<0.05).	Thioguanine	132-134	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	9-13
31949496-11	2020	Conclusion: The BRAF V600E mutation is closely related to serum Tg elevation after treatment with iodine-131 in papillary thyroid cancer.	Thioguanine	64-66	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	16-20
31422915-8	2019	These data suggest that Lro1 nuclear targeting provides a site of TG synthesis, which is coupled with nuclear membrane remodeling.	Thioguanine	66-68	phospholipid:diacylglycerol acyltransferase	Saccharomyces cerevisiae S288C	24-28
31254901-9	2019	Western blotting indicated that atrogin-1 and MuRF1 levels were lower in the TG-BG group than in the TG group but were not suppressed in the TG-B or TG-G group.	Thioguanine	77-79	F-box protein 32	Rattus norvegicus	32-41
31254901-9	2019	Western blotting indicated that atrogin-1 and MuRF1 levels were lower in the TG-BG group than in the TG group but were not suppressed in the TG-B or TG-G group.	Thioguanine	77-79	tripartite motif containing 63	Rattus norvegicus	46-51
31254901-10	2019	CONCLUSIONS: In a rodent sarcopenia model induced by TG, the administration of BCAA in combination with Gln more effectively inhibited muscle atrophy than the administration of BCAA or Gln alone.	Thioguanine	53-55	AT-rich interaction domain 4B	Rattus norvegicus	79-83
31604438-1	2019	BACKGROUND: Previous studies have reported that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio could be a simple clinical indicator of insulin resistance (IR), but the results indicated that there were heterogeneities between different ethnicities.	Thioguanine	106-108	insulin	Homo sapiens	162-169
31625373-9	2019	Spearman"s correlation assay demonstrated that the correlation between the expression of miR-1296 and blood lipids, including TC, TG, HDL-c, and LDL-c, was TC (r = 0.4951, p = 0.0013), TG (r = 0.054, p = 0.6425), HDL-C (r = 0.3435, p = 0.07522), and LDL-C (r = 0.3307, p = 0.0699.	Thioguanine	130-132	microRNA 1296	Homo sapiens	89-97
31625373-9	2019	Spearman"s correlation assay demonstrated that the correlation between the expression of miR-1296 and blood lipids, including TC, TG, HDL-c, and LDL-c, was TC (r = 0.4951, p = 0.0013), TG (r = 0.054, p = 0.6425), HDL-C (r = 0.3435, p = 0.07522), and LDL-C (r = 0.3307, p = 0.0699.	Thioguanine	185-187	microRNA 1296	Homo sapiens	89-97
31429291-4	2019	In particular, wavelength-dependent 3D defocused TG imaging (3D TG-TIRSDM) separated silver nanotag and gold nanoplate signals on a NoVP immunoplasmon chip along the x, y, and z coordinates simultaneously.	Thioguanine	49-51	plexin A1	Homo sapiens	132-136
31488013-13	2019	Increased oxidative stress will suppress the expression of ACSL1, which could increase the intracellular FFA and TG contents, ultimately leading to renal lipid deposition in renal tubulars and accelerating the development of ORN.	Thioguanine	113-115	acyl-CoA synthetase long-chain family member 1	Mus musculus	59-64
31449060-7	2019	These impactful mouse studies were supported by the initial finding that APOC3 predicted coronary artery disease events in participants of the prospective Coronary Artery Calcification in Type 1 Diabetes study with normal TG levels.	Thioguanine	222-224	apolipoprotein C-III	Mus musculus	73-78
31599445-10	2019	Furthermore, we demonstrated that CLS1 suppression significantly ameliorated the liver function and decreased the TG level, and interleukin-1beta (IL-1beta) and IL-18 were markedly reduced upon CLS1 inhibition.	Thioguanine	114-116	CD52 antigen	Mus musculus	34-38
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Mus musculus	99-102
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	Thioguanine	13-15	cystathionine beta-synthase	Mus musculus	22-25
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Mus musculus	41-44
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Homo sapiens	167-171
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Mus musculus	172-175
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	13-15	cystathionine beta-synthase	Mus musculus	22-25
30702924-2	2019	Fat is predominately stored in adipose tissue as triacylglycerides (TG); however, TG are also stored in other tissues including the liver and skeletal muscle.	Thioguanine	68-70	FAT atypical cadherin 1	Homo sapiens	0-3
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	13-15	cystathionine beta-synthase	Homo sapiens	186-190
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	13-15	cystathionine beta-synthase	Mus musculus	191-194
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	183-185	cystathionine beta-synthase	Mus musculus	22-25
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	183-185	cystathionine beta-synthase	Homo sapiens	186-190
31413305-15	2019	miR-181d can be used as an inhibitor of ANGPTL3 to reduce the TG plasma level.	Thioguanine	62-64	microRNA 181d	Homo sapiens	0-8
31413305-15	2019	miR-181d can be used as an inhibitor of ANGPTL3 to reduce the TG plasma level.	Thioguanine	62-64	angiopoietin like 3	Homo sapiens	40-47
31187654-9	2019	There was a positive correlation between galectin-3 concentrations and TSH, anti-Tg and triglyceride concentrations; while a negative correlation was present between fT4 and fT3 and galectin-3 concentrations (p < .05).	Thioguanine	81-83	galectin 3	Homo sapiens	41-51
30702924-2	2019	Fat is predominately stored in adipose tissue as triacylglycerides (TG); however, TG are also stored in other tissues including the liver and skeletal muscle.	Thioguanine	82-84	FAT atypical cadherin 1	Homo sapiens	0-3
31367237-8	2019	Pearson"s correlation analysis showed that serum visfatin levels were positively correlated with waist circumference (r = 0.226, P = 0.029), waist-hip ratio (r = 0.221, P = 0.032), TG (r = 0.222, P = 0.030) and number of plaques (r = 0.275, P = 0.009).	Thioguanine	181-183	nicotinamide phosphoribosyltransferase	Homo sapiens	49-57
30839094-13	2019	Finally, we observed a notable reduction in podocyte apoptotic rate in DKD serum + siRNA-beta-arrestin-1 + TG group compared to DKD serum + siRNA-beta-arrestin-1 group, and upregulated protein levels of nephrin and podocin compared to treatment with siRNA-beta-arrestin-1 only.	Thioguanine	107-109	arrestin, beta 1	Mus musculus	89-104
30839094-13	2019	Finally, we observed a notable reduction in podocyte apoptotic rate in DKD serum + siRNA-beta-arrestin-1 + TG group compared to DKD serum + siRNA-beta-arrestin-1 group, and upregulated protein levels of nephrin and podocin compared to treatment with siRNA-beta-arrestin-1 only.	Thioguanine	107-109	nephrosis 1, nephrin	Mus musculus	203-210
30839094-13	2019	Finally, we observed a notable reduction in podocyte apoptotic rate in DKD serum + siRNA-beta-arrestin-1 + TG group compared to DKD serum + siRNA-beta-arrestin-1 group, and upregulated protein levels of nephrin and podocin compared to treatment with siRNA-beta-arrestin-1 only.	Thioguanine	107-109	nephrosis 2, podocin	Mus musculus	215-222
30262821-7	2019	Using the fgwas method we found that SNPs, which influence high-density lipoprotein cholesterol (log2 enrichment of 3.35, 95% CI: (0.92, 4.48)) and TG (log enrichment of 3.22, 95% CI: (1.18, 4.44)), were enriched in m6A methylation.	Thioguanine	148-150	glycoprotein M6A	Homo sapiens	216-219
30633352-7	2019	In addition, TC and TG levels induced by ox-LDL was rescued by UCA1 small interfering RNA.	Thioguanine	20-22	urothelial cancer associated 1	Homo sapiens	63-67
30929133-7	2019	In vitro studies revealed that the recombinant ANGPTL8/betatrophin had no proliferation effect on MIN6 cells but promoted TG levels in HepG2 cells.	Thioguanine	122-124	angiopoietin-like 8	Mus musculus	47-54
30929133-7	2019	In vitro studies revealed that the recombinant ANGPTL8/betatrophin had no proliferation effect on MIN6 cells but promoted TG levels in HepG2 cells.	Thioguanine	122-124	angiopoietin-like 8	Mus musculus	55-66
31624796-9	2019	Oral contraception (OC) possibly influenced TG parameters, resulting in a higher median and a broader reference interval for peak height and endogenous thrombin potential (ETP) in women aged 20 to 49 years than in all other sex and age categories.	Thioguanine	44-46	coagulation factor II, thrombin	Homo sapiens	152-160
31210194-3	2019	Here, we found that the serum LDL-C, TG and TC levels were elevated and the HDL-C level was decreased in HFD-fed ApoE-/- mice.	Thioguanine	37-39	apolipoprotein E	Mus musculus	113-117
31186446-5	2019	ER stress and pro-inflammation markers were significantly higher in Agt-Tg compared to Wt mice and captopril significantly reduced their expression.	Thioguanine	72-74	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	68-71
30902787-8	2019	Also subjects who carried the G allele of the ZNF259 polymorphism were at an increased the risk of developing CAD [OR 1.86, 95% CI: 1.06-3.25, p value = 0.029] and had an increased TC, LDL and TG levels (p &lt; 0.05).	Thioguanine	193-195	ZPR1 zinc finger	Homo sapiens	46-52
31030323-5	2019	To characterize the C1INH effects on TG and PG, the thrombin and plasmin concentration peaks and production rates were calculated.	Thioguanine	37-39	serpin family G member 1	Homo sapiens	20-25
31030323-6	2019	TM addition to donor plasma shifted the concentration dependence of C1INH on TG parameters from reduction to enhancement.	Thioguanine	77-79	thrombomodulin	Homo sapiens	0-2
31030323-6	2019	TM addition to donor plasma shifted the concentration dependence of C1INH on TG parameters from reduction to enhancement.	Thioguanine	77-79	serpin family G member 1	Homo sapiens	68-73
31030323-8	2019	Moderate C1INH concentration (3 IU/ml) reduced TG and PG in the absence of TM but did not significantly affect these parameters in the presence of TM.	Thioguanine	47-49	serpin family G member 1	Homo sapiens	9-14
31292457-10	2019	Also, in the cohort n o association between HTGC and CETP was present (beta: -0.001 microg/mL per SD TG, 95%CI[-0.005, 0.003]).	Thioguanine	45-47	cholesteryl ester transfer protein	Homo sapiens	53-57
31186072-1	2019	Triglyceride deposit cardiomyovasculopathy (TGCV) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) which releases long chain fatty acid (LCFA) as a major energy source by the intracellular TG hydrolysis.	Thioguanine	44-46	patatin like phospholipase domain containing 2	Homo sapiens	126-132
31186072-1	2019	Triglyceride deposit cardiomyovasculopathy (TGCV) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) which releases long chain fatty acid (LCFA) as a major energy source by the intracellular TG hydrolysis.	Thioguanine	44-46	patatin like phospholipase domain containing 2	Homo sapiens	142-169
30965234-9	2019	Treatment with TG (40, 80, and 160 mg/kg/d) ameliorated pulmonary fibrosis induced by bleomycin in mice, downregulated the expression of TGF-beta1, Smad2, Smad3, MMP-2, MMP-9, and tissue inhibitor of metalloproteinase-1, and upregulated the protein expression of Smad7.	Thioguanine	15-17	transforming growth factor, beta 1	Mus musculus	137-146
31186072-1	2019	Triglyceride deposit cardiomyovasculopathy (TGCV) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) which releases long chain fatty acid (LCFA) as a major energy source by the intracellular TG hydrolysis.	Thioguanine	44-46	patatin like phospholipase domain containing 2	Homo sapiens	171-175
30965234-9	2019	Treatment with TG (40, 80, and 160 mg/kg/d) ameliorated pulmonary fibrosis induced by bleomycin in mice, downregulated the expression of TGF-beta1, Smad2, Smad3, MMP-2, MMP-9, and tissue inhibitor of metalloproteinase-1, and upregulated the protein expression of Smad7.	Thioguanine	15-17	SMAD family member 2	Mus musculus	148-153
30965234-9	2019	Treatment with TG (40, 80, and 160 mg/kg/d) ameliorated pulmonary fibrosis induced by bleomycin in mice, downregulated the expression of TGF-beta1, Smad2, Smad3, MMP-2, MMP-9, and tissue inhibitor of metalloproteinase-1, and upregulated the protein expression of Smad7.	Thioguanine	15-17	SMAD family member 3	Mus musculus	155-160
30965234-9	2019	Treatment with TG (40, 80, and 160 mg/kg/d) ameliorated pulmonary fibrosis induced by bleomycin in mice, downregulated the expression of TGF-beta1, Smad2, Smad3, MMP-2, MMP-9, and tissue inhibitor of metalloproteinase-1, and upregulated the protein expression of Smad7.	Thioguanine	15-17	matrix metallopeptidase 2	Mus musculus	162-167
30965234-9	2019	Treatment with TG (40, 80, and 160 mg/kg/d) ameliorated pulmonary fibrosis induced by bleomycin in mice, downregulated the expression of TGF-beta1, Smad2, Smad3, MMP-2, MMP-9, and tissue inhibitor of metalloproteinase-1, and upregulated the protein expression of Smad7.	Thioguanine	15-17	matrix metallopeptidase 9	Mus musculus	169-174
30965234-9	2019	Treatment with TG (40, 80, and 160 mg/kg/d) ameliorated pulmonary fibrosis induced by bleomycin in mice, downregulated the expression of TGF-beta1, Smad2, Smad3, MMP-2, MMP-9, and tissue inhibitor of metalloproteinase-1, and upregulated the protein expression of Smad7.	Thioguanine	15-17	tissue inhibitor of metalloproteinase 1	Mus musculus	180-219
30965234-9	2019	Treatment with TG (40, 80, and 160 mg/kg/d) ameliorated pulmonary fibrosis induced by bleomycin in mice, downregulated the expression of TGF-beta1, Smad2, Smad3, MMP-2, MMP-9, and tissue inhibitor of metalloproteinase-1, and upregulated the protein expression of Smad7.	Thioguanine	15-17	SMAD family member 7	Mus musculus	263-268
30965234-10	2019	These results suggest that the protective effects of TG on pulmonary fibrosis induced by bleomycin are related to regulation of the TGF-beta1/Smad signalling pathway and MMP system.	Thioguanine	53-55	transforming growth factor, beta 1	Mus musculus	132-141
30965234-10	2019	These results suggest that the protective effects of TG on pulmonary fibrosis induced by bleomycin are related to regulation of the TGF-beta1/Smad signalling pathway and MMP system.	Thioguanine	53-55	SMAD family member 7	Mus musculus	142-146
30922570-3	2019	Aging mice in which KCNB1 oligomerization is negligible (Tg-C73A), performed significantly better in the Morris Water Maze (MWM) test of working memory compared to non-Tg or Tg-WT mice.	Thioguanine	57-59	potassium voltage gated channel, Shab-related subfamily, member 1	Mus musculus	20-25
31232032-9	2019	Furthermore, peripheral blood miR-937 level posi-tively correlated with serum glucose level (r = 0.556, p &lt; 0.01) as well as total serum TG/TC levels (r = 0.455, p &lt; 0.01).	Thioguanine	140-142	microRNA 937	Homo sapiens	30-37
30131522-6	2019	Statistically significant tendency of having dyslipidemia was observed with decreasing frequency of having breakfast in total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides in males (LDL-C: p for trend &lt; 0.0001, TG: p for trend = 0.0004), but not in females.	Thioguanine	244-246	component of oligomeric golgi complex 2	Homo sapiens	212-217
31191331-11	2019	Serum levels of miR-24 and miR-155 in the TG group were also lower than in the CG group (p &lt; 0.05).	Thioguanine	42-44	microRNA 155	Homo sapiens	27-34
30447069-4	2019	We provide recommendations for adjusting starting doses of azathioprine, mercaptopurine, and thioguanine based on TPMT and NUDT15 genotypes (updates on www.cpicpgx.org).	Thioguanine	93-104	thiopurine S-methyltransferase	Homo sapiens	114-118
30735855-4	2019	We showed that protection was observed in iPla2beta-null mice with an attenuation of diet-induced body and liver-weight gains, liver enzymes, serum free fatty acids as well as hepatic TG and steatosis scores.	Thioguanine	184-186	phospholipase A2, group VI	Mus musculus	42-51
30984441-2	2019	The new sensor, labelled as GrO-IL-AuNPs-Chit/CSE, exhibited an improved electrocatalytic response to cancer drugs such as purine antimetabolites (6-thioguanine, 6-mercaptopurine, and azathioprine) in a wide concentration range with a low detection limit (20-40 nmol L-1, S/N = 3), and satisfactory recoveries (97.1-103.0%).	Thioguanine	147-160	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	46-49
30879770-10	2019	In summary, we are the first to discover the interaction between Sfrp5 and Slurp1, and we found that Slurp1 may regulate the accumulation of TG through Sfrp5.	Thioguanine	141-143	secreted frizzled related protein 5	Homo sapiens	65-70
30879770-10	2019	In summary, we are the first to discover the interaction between Sfrp5 and Slurp1, and we found that Slurp1 may regulate the accumulation of TG through Sfrp5.	Thioguanine	141-143	secreted LY6/PLAUR domain containing 1	Homo sapiens	75-81
30879770-10	2019	In summary, we are the first to discover the interaction between Sfrp5 and Slurp1, and we found that Slurp1 may regulate the accumulation of TG through Sfrp5.	Thioguanine	141-143	secreted LY6/PLAUR domain containing 1	Homo sapiens	101-107
30879770-10	2019	In summary, we are the first to discover the interaction between Sfrp5 and Slurp1, and we found that Slurp1 may regulate the accumulation of TG through Sfrp5.	Thioguanine	141-143	secreted frizzled related protein 5	Homo sapiens	152-157
30259979-8	2019	As exhibited, CD36, oil-red staining levels, total cholesterol (TC), total cholesterol (TG) levels and THP-1 cell apoptosis were obviously repressed by knockdown of NEAT1.	Thioguanine	88-90	nuclear paraspeckle assembly transcript 1	Homo sapiens	165-170
30896961-12	2019	Serum Tbeta4 levels had a significant negative correlation with total cholesterol, TG, AST, GGT and IL-6 (p < 0.05 for all) and the correlation coefficient values were -0.163, -0.253, -0.143, -0.245 and -0.155, respectively.	Thioguanine	83-85	trace amine associated receptor 6	Homo sapiens	6-12
30670595-5	2019	Tg-ACE and Tg-NKO mice exhibited strongly suppressed growth of B16-F10 melanoma because of increased ACE expression in macrophages, whereas Tg-CKO mice resisted melanoma no better than WT animals.	Thioguanine	0-2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	3-6
30746892-12	2019	Both VEGFC and VEGFR3 gene expression presented significant difference between CG and SG, between SG and TG and between CG and TG.	Thioguanine	105-107	vascular endothelial growth factor C	Mus musculus	5-10
30746892-12	2019	Both VEGFC and VEGFR3 gene expression presented significant difference between CG and SG, between SG and TG and between CG and TG.	Thioguanine	105-107	FMS-like tyrosine kinase 4	Mus musculus	15-21
31038568-6	2019	The genotype frequencies of the SNP ADIPOQ +45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, pcorr&gt;0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p&lt;0.01, pcorr&gt;0.05).	Thioguanine	229-231	adiponectin, C1Q and collagen domain containing	Homo sapiens	36-42
30770470-5	2019	The deacetylation mimetic mutant, but not the WT and the acetylation mimetic mutant, of MLH1 confers resistance to 6-thioguanine.	Thioguanine	115-128	mutL homolog 1	Homo sapiens	88-92
30547189-4	2019	This study aims to evaluate the role of platelets contributing to hypercoagulability in NTDT patients using thrombin generation (TG).	Thioguanine	129-131	coagulation factor II, thrombin	Homo sapiens	108-116
30269201-8	2019	However, the students with PTSD had significantly lower levels of glucose, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) than the students without PTSD in the C allele carriers of GHSR rs495225 after the adjustment for age, gender and body mass index (BMI), but higher levels of TG and TG/HDL-C in the TT homozygotes.	Thioguanine	306-308	growth hormone secretagogue receptor	Homo sapiens	207-211
30269201-11	2019	PTSD may augment TG levels and the related lipid ratio TG/HDL-C in the TT homozygotes of GHSR rs495225 but decrease the levels of glucose, insulin and HOMA-IR in the C allele carriers.	Thioguanine	17-19	growth hormone secretagogue receptor	Homo sapiens	89-93
30269201-11	2019	PTSD may augment TG levels and the related lipid ratio TG/HDL-C in the TT homozygotes of GHSR rs495225 but decrease the levels of glucose, insulin and HOMA-IR in the C allele carriers.	Thioguanine	55-57	growth hormone secretagogue receptor	Homo sapiens	89-93
29374794-6	2019	A significant interaction was observed between ApoB Ins/Del and diet on TG in both unadjusted (P = 0.03) and adjusted models (model 2 and 3, P = 0.04 and P = 0.04, respectively), and on LDL-C only in adjusted models (model 2 and 3, P = 0.03 and P = 0.029, respectively).	Thioguanine	72-74	apolipoprotein B	Homo sapiens	47-51
29374794-10	2019	CONCLUSIONS: These findings indicate that the interaction between ApoB Ins/Del and dietary intake of MUFA, SFA, n-3PUFA, carbohydrate and protein could modulate the serum levels of TG, LDL-C, leptin and ghrelin in T2DM patients.	Thioguanine	181-183	apolipoprotein B	Homo sapiens	66-70
29374794-10	2019	CONCLUSIONS: These findings indicate that the interaction between ApoB Ins/Del and dietary intake of MUFA, SFA, n-3PUFA, carbohydrate and protein could modulate the serum levels of TG, LDL-C, leptin and ghrelin in T2DM patients.	Thioguanine	181-183	pumilio RNA binding family member 3	Homo sapiens	115-119
29374794-10	2019	CONCLUSIONS: These findings indicate that the interaction between ApoB Ins/Del and dietary intake of MUFA, SFA, n-3PUFA, carbohydrate and protein could modulate the serum levels of TG, LDL-C, leptin and ghrelin in T2DM patients.	Thioguanine	181-183	leptin	Homo sapiens	192-198
30670595-5	2019	Tg-ACE and Tg-NKO mice exhibited strongly suppressed growth of B16-F10 melanoma because of increased ACE expression in macrophages, whereas Tg-CKO mice resisted melanoma no better than WT animals.	Thioguanine	0-2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	101-104
30670595-5	2019	Tg-ACE and Tg-NKO mice exhibited strongly suppressed growth of B16-F10 melanoma because of increased ACE expression in macrophages, whereas Tg-CKO mice resisted melanoma no better than WT animals.	Thioguanine	11-13	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	101-104
30670595-8	2019	Tumor necrosis factor alpha (TNFalpha) is important for M1 activation, and TNFalpha blockade reverted Tg-NKO macrophages to a WT phenotype.	Thioguanine	102-104	tumor necrosis factor	Mus musculus	0-27
30670595-8	2019	Tumor necrosis factor alpha (TNFalpha) is important for M1 activation, and TNFalpha blockade reverted Tg-NKO macrophages to a WT phenotype.	Thioguanine	102-104	tumor necrosis factor	Mus musculus	75-83
30380496-5	2019	The main fractions of Hg in the salt slurry and soils were Hg2+ and Hg0, which accounted for 47.4% and 22.9% of THg in the salt slurry and 28.0% and 43.8% of THg in the soils on average, respectively.	Thioguanine	112-115	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	59-62
30293189-8	2019	MODY3 subjects exhibited with younger, lower BMI, TG, fasting and postprandial C-peptide, higher HDL than T2DM.	Thioguanine	50-52	HNF1 homeobox A	Homo sapiens	0-5
30006830-10	2019	The stepwise logistic regression analysis revealed that CRP on POD3 &gt;= 12 mg/dl [odds ratio (OR) 2.08, 95% confidence interval (CI) 1.09-3.95, p = 0.025], laparoscopic surgery (OR 2.25, 95% CI 1.17-4.31, p = 0.015), and TG (OR 2.23, 95% CI 1.17-4.78, p = 0.023) were found to be independent risk factors for readmission.	Thioguanine	223-225	C-reactive protein	Homo sapiens	56-59
30657241-8	2019	The OR (95% CI) of the highest TG/HDL ratio quartile as compared to the lowest TG/HDL ratio quartile for high PWV was 2.77 (1.16-6.63) after adjusting for age, BMI, smoking status, regular exercise, mean arterial pressure, fasting plasma glucose, total cholesterol level, hypertension, log-transformed C-reactive protein, and the use of antihypertensive and lipid-lowering drugs.	Thioguanine	31-33	C-reactive protein	Homo sapiens	302-320
30008072-4	2019	Here, we found that a novel compound, TG-2112x, can inhibit only the lower concentrations mitochondrial calcium uptake (induced by 100 nM-5 muM) but not the uptake induced by higher concentrations of calcium (10 muM and higher).	Thioguanine	38-40	latexin	Homo sapiens	140-143
30008072-4	2019	Here, we found that a novel compound, TG-2112x, can inhibit only the lower concentrations mitochondrial calcium uptake (induced by 100 nM-5 muM) but not the uptake induced by higher concentrations of calcium (10 muM and higher).	Thioguanine	38-40	latexin	Homo sapiens	212-215
30039993-4	2019	In aging males, after adjusting for age, the negative association between osteocalcin and BMI, waist circumference, FPG, 2hPBG, or TG were significant.	Thioguanine	131-133	bone gamma-carboxyglutamate protein	Homo sapiens	74-85
30761568-7	2019	In a post hoc subgroup analysis in patients with baseline CRP &lt;3 mg/L, a significant increase in CRP was observed in CG (1.44 +- 0.82 mg/L to 4.35 +- 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 +- 0.96 mg/L to 1.33 +- 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months.	Thioguanine	209-211	C-reactive protein	Homo sapiens	100-103
30761568-7	2019	In a post hoc subgroup analysis in patients with baseline CRP &lt;3 mg/L, a significant increase in CRP was observed in CG (1.44 +- 0.82 mg/L to 4.35 +- 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 +- 0.96 mg/L to 1.33 +- 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months.	Thioguanine	209-211	C-reactive protein	Homo sapiens	100-103
30761568-8	2019	In patients with CRP &gt;=3 mg/L, a significant reduction in CRP was observed only in TG (11.3 +- 12.8 mg/L to 5.7 +- 4.1 mg/L, p = 0.04).	Thioguanine	86-88	C-reactive protein	Homo sapiens	17-20
30761568-8	2019	In patients with CRP &gt;=3 mg/L, a significant reduction in CRP was observed only in TG (11.3 +- 12.8 mg/L to 5.7 +- 4.1 mg/L, p = 0.04).	Thioguanine	86-88	C-reactive protein	Homo sapiens	61-64
30761568-9	2019	Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months.	Thioguanine	52-54	interleukin 6	Homo sapiens	10-14
30761568-9	2019	Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months.	Thioguanine	52-54	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
30420202-7	2019	RESULTS: When participants were analyzed according to CCR5-Delta32 polymorphism, Delta32 carriers presented higher levels of: HbA1c (p < 0.001), fasting plasma glucose (p < 0.001), LDL (p = 0.02) as well as TG (p = 0.01) and lower levels of HDL (p = 0.01) than noncarriers.	Thioguanine	207-209	C-C motif chemokine receptor 5	Homo sapiens	54-58
30666271-8	2018	The overall pooled analysis indicated that STAT4 rs7574865 polymorphism was significantly associated with AITD susceptibility [TT vs. GG: OR = 1.63, 95%CI = 1.24-2.15, P Z = 0.0005; TT vs. (TG+GG): OR = 1.55, 95%CI = 1.26-1.91, P Z &lt; 0.0001].	Thioguanine	190-192	signal transducer and activator of transcription 4	Homo sapiens	43-48
30668566-8	2019	Concomitantly, iNOS (inducible nitric oxide synthase) was upregulated 2-fold in Tg+cART rats, which was reversed by Mg-supplementation.	Thioguanine	80-82	nitric oxide synthase 2	Rattus norvegicus	15-19
30668566-8	2019	Concomitantly, iNOS (inducible nitric oxide synthase) was upregulated 2-fold in Tg+cART rats, which was reversed by Mg-supplementation.	Thioguanine	80-82	nitric oxide synthase 2	Rattus norvegicus	21-52
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Thioguanine	52-54	bone morphogenetic protein 1	Homo sapiens	113-139
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Thioguanine	52-54	bone morphogenetic protein 2	Homo sapiens	141-146
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Thioguanine	166-168	bone morphogenetic protein 1	Homo sapiens	113-139
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Thioguanine	166-168	bone morphogenetic protein 2	Homo sapiens	141-146
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Thioguanine	166-168	bone morphogenetic protein 2	Homo sapiens	256-261
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Thioguanine	52-55	bone morphogenetic protein 1	Homo sapiens	113-139
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Thioguanine	52-55	bone morphogenetic protein 2	Homo sapiens	141-146
30522790-0	2019	The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, beta-cell function, and diabetes in Hispanics and African Americans.	Thioguanine	58-60	insulin	Homo sapiens	92-99
30677071-4	2019	One of the hits, D0713 (IC50 = 62 muM) bearing thioguanine scaffold was derivatised into 21 compounds and evaluated for DENV-2 NS2B/NS3 protease inhibitory activity.	Thioguanine	47-58	latexin	Homo sapiens	34-37
30642114-9	2019	In particular, there was a strong positive association between serum triglyceride levels (TG) with PPARA and LPL methylation levels.	Thioguanine	90-92	peroxisome proliferator activated receptor alpha	Homo sapiens	99-104
30642114-9	2019	In particular, there was a strong positive association between serum triglyceride levels (TG) with PPARA and LPL methylation levels.	Thioguanine	90-92	lipoprotein lipase	Homo sapiens	109-112
30300671-6	2019	Treatment with vitamin E (0.5 g/kg) for 3 weeks improved VLDL-TG secretion and normalized cholesterol metabolism, but failed to reduce hepatic TG content.	Thioguanine	62-64	CD320 antigen	Mus musculus	57-61
31787724-6	2019	The decreased level of adiponectin by a high-fat diet was also recovered by THG-A treatment.	Thioguanine	76-79	adiponectin, C1Q and collagen domain containing	Mus musculus	23-34
31787724-8	2019	However, the increased IL-6 levels in mice fed a high-fat diet were significantly suppressed by THG-A treatment.	Thioguanine	96-99	interleukin 6	Mus musculus	23-27
30445307-4	2019	Our results showed that alcohol feeding induced significant steatohepatitis and liver injury, which were mitigated by P2X7R blockade as evidenced by decreased serum levels of ALT, AST, T-CHO and TG, reduced lipid accumulation, and less inflammation.	Thioguanine	195-197	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	118-123
30641729-1	2019	AIM: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults.	Thioguanine	76-78	insulin	Homo sapiens	96-103
30451123-1	2019	BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme that catalyzes thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	132-145	thiopurine S-methyltransferase	Homo sapiens	12-42
30451123-1	2019	BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme that catalyzes thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	132-145	thiopurine S-methyltransferase	Homo sapiens	44-48
30451123-11	2019	TPMT enzyme activity was higher in wild-type than that mutant variants TPMT*1/*2 and TPMT*1/*3C, suggesting that there are statistically significant differences between 6-TG levels and polymorphisms of TMPT enzyme.	Thioguanine	169-173	thiopurine S-methyltransferase	Homo sapiens	0-4
30451123-11	2019	TPMT enzyme activity was higher in wild-type than that mutant variants TPMT*1/*2 and TPMT*1/*3C, suggesting that there are statistically significant differences between 6-TG levels and polymorphisms of TMPT enzyme.	Thioguanine	169-173	thiopurine S-methyltransferase	Homo sapiens	71-75
30451123-11	2019	TPMT enzyme activity was higher in wild-type than that mutant variants TPMT*1/*2 and TPMT*1/*3C, suggesting that there are statistically significant differences between 6-TG levels and polymorphisms of TMPT enzyme.	Thioguanine	169-173	thiopurine S-methyltransferase	Homo sapiens	71-75
30451123-12	2019	6-TG levels significantly increased in IBD patients mutant variants TPMT*1/*2 and TPMT*1/*3C.	Thioguanine	0-4	thiopurine S-methyltransferase	Homo sapiens	68-72
30451123-12	2019	6-TG levels significantly increased in IBD patients mutant variants TPMT*1/*2 and TPMT*1/*3C.	Thioguanine	0-4	thiopurine S-methyltransferase	Homo sapiens	82-86
31473954-4	2019	The identification and selective expansion of mutant lymphocytes is based upon the phenotypic properties of Hprt- and Pig-a-deficient cells, that is, resistance to the purine analog, 6-thioguanine, or to the bacterial toxin, proaerolysin.	Thioguanine	183-196	hypoxanthine phosphoribosyltransferase 1	Sus scrofa	108-112
30918833-8	2019	In Logistic Regression analysis, variables like Increased age, alcohol intake, high WC, raised TG level, raised FBS level and high average DBP were strongly associated with MetS as it was statistically significant.	Thioguanine	95-97	ETS variant transcription factor 3	Homo sapiens	173-177
30096032-8	2019	Lastly, a nonlinear relationship of plasma Hp and whole blood total mercury concentrations (THg) was observed in SSLs from the endangered western distinct population segment in Alaska.	Thioguanine	92-95	haptoglobin	Eumetopias jubatus	43-45
30096032-9	2019	These results demonstrated that regional variation in Hp, especially in younger SSLs, may reflect regional differences in health and circulating THg.	Thioguanine	145-148	haptoglobin	Eumetopias jubatus	54-56
31473954-4	2019	The identification and selective expansion of mutant lymphocytes is based upon the phenotypic properties of Hprt- and Pig-a-deficient cells, that is, resistance to the purine analog, 6-thioguanine, or to the bacterial toxin, proaerolysin.	Thioguanine	183-196	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	118-123
30903769-11	2019	According to the carried-out correlation analysis there was revealed existence of direct integral probable connections between PTX-3 level and levels of glucose (r = 0.41; p &lt;0,05), insulin (r = 0.36; p &lt;0,05), index of HOMA (r = 0.89; p &lt;0,05), TG level (r = 0.74; p &lt;0,05) and the return with the HDL (r = - 0.54; p &lt;0,05).	Thioguanine	255-257	pentraxin 3	Homo sapiens	127-132
30053273-9	2019	The incorporation of ptc1diffuse in the MVI score &gt;=2 increased the receiver operating characteristics curve for TG [area under the curve (AUC) 0.602; P = 0.008] compared with a Banff MVI score &gt;=2 (AUC 0.56; P = 0.12); cases with baseline TG were excluded.	Thioguanine	116-118	patched 1	Homo sapiens	21-25
30053273-10	2019	In multivariate analysis, ptc1diffuse remained independently related to TG (odds ratio 3.89; P = 0.008) and graft loss (hazard ratio 2.64; P = 0.001) even after inclusion of all rejection episodes.	Thioguanine	72-74	patched 1	Homo sapiens	26-30
30560214-6	2018	However, screening of synthesized thioguanine derivatives using the optimized AlphaScreen  assay revealed weak NS2B/NS3 inhibition activities.	Thioguanine	34-45	KRAS proto-oncogene, GTPase	Homo sapiens	116-119
30643053-1	2018	Apolipoprotein A5 (Apo A5) is a novel member in apolipoprotein family, which is proven to be an important regulator in triglyceride metabolism, especially in adjusting the TG content in plasma.	Thioguanine	172-174	apolipoprotein A5	Homo sapiens	0-17
30643053-1	2018	Apolipoprotein A5 (Apo A5) is a novel member in apolipoprotein family, which is proven to be an important regulator in triglyceride metabolism, especially in adjusting the TG content in plasma.	Thioguanine	172-174	apolipoprotein A5	Homo sapiens	19-25
30820332-2	2019	In persons with obesity plasma ANGPTL4 levels have been positively correlated with body fat mass, TG levels and low HDL.	Thioguanine	98-100	angiopoietin like 4	Homo sapiens	31-38
30484310-8	2018	In addition, mechanism regulation also implied that an IGF2 inhibitor and PI3K inhibitor may be used for the NAFLD precautionary measure to reduce TG deposition.	Thioguanine	147-149	insulin like growth factor 2	Gallus gallus	55-59
30474969-3	2018	Fluvial concentrations of THg and MeHg downstream of RTSs on the Peel Plateau (Northwest Territories, Canada) were up to 2 orders of magnitude higher than upstream, reaching concentrations of 1,270 ng L-1 and 7 ng L-1, respectively, the highest ever measured in uncontaminated sites in Canada.	Thioguanine	26-29	L1 cell adhesion molecule	Homo sapiens	201-217
30440130-5	2018	Meta-analysis: In terms of the effect of UGT1A4 142T&gt;G polymorphism on the serum concentration/dose ratio(CDR)of LTG, there was no significant difference between the wild-type(TT genotype)group and mutant-type (TG+ GG genotype) group (MD=-0.08, 95% CI (-0.40-0.23)).	Thioguanine	117-119	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	41-47
30451245-1	2018	The triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) is a useful surrogate marker of insulin resistance and cardiovascular risk factors.	Thioguanine	65-67	insulin	Homo sapiens	107-114
30410583-9	2018	Conclusion: Our data revealed a pleiotropic association between the LIPC variants and visceral adiposity indicators and TyG index-related parameters, which are mediated by serum TG levels.	Thioguanine	178-180	lipase C, hepatic type	Homo sapiens	68-72
30372866-6	2018	The results showed that CAPE-pNO2 can alleviate CK, LDH, TC and TG levels, as well as depress the activity of ROS by down-regulating the expression of NOX4 and improving SOD activity in the serum of STZ-induced DCM mice.	Thioguanine	64-66	structural maintenance of chromosomes 2	Mus musculus	24-28
30402862-13	2018	There was a positive correlation between GPIIb/IIIa and hs-cTnT, FPG, LDL, TC, TG, BMI, and smoking index, and a negative correlation with HDL (p &lt; 0.05).	Thioguanine	79-81	integrin subunit alpha 2b	Homo sapiens	41-46
30379500-6	2018	Thiopurine methyltransferase (TPMT) genotyping proved that the patient was a poor metaboliser of thioguanine (TPMT3A*/3A*).	Thioguanine	97-108	thiopurine S-methyltransferase	Homo sapiens	0-28
30379500-6	2018	Thiopurine methyltransferase (TPMT) genotyping proved that the patient was a poor metaboliser of thioguanine (TPMT3A*/3A*).	Thioguanine	97-108	thiopurine S-methyltransferase	Homo sapiens	30-34
30270088-7	2018	In the whole group, PCSK9 concentration correlated with age, statins intake, Lp(a), TC and TG levels.	Thioguanine	91-93	proprotein convertase subtilisin/kexin type 9	Homo sapiens	20-25
30021325-10	2018	Our higher CO2 emission (1.47 (1.16-2.13) Tg CO2/y) than previous studies called more field measurements to assess the resulting changes in CO2 flux owing to dam operation and changing environment, and their implications for regional carbon budgets should be warranted.	Thioguanine	42-44	complement C2	Homo sapiens	45-50
30347712-8	2018	Metformin reduced miR-222, miR-195 and miR-21a levels in TG; p = 0.007, p = 0.002 p = 0.0012, respectively.	Thioguanine	57-59	microRNA 222	Homo sapiens	18-25
30347712-8	2018	Metformin reduced miR-222, miR-195 and miR-21a levels in TG; p = 0.007, p = 0.002 p = 0.0012, respectively.	Thioguanine	57-59	microRNA 195	Homo sapiens	27-34
29956222-7	2018	Furthermore, the rs7574865 polymorphism was significantly associated with PBC risk under all genotype genetic models (dominant effect model: TT + TG vs. GG, OR = 1.43, 95% CI 1.19-1.71; recessive effect: TT vs. TG + GG, OR = 1.40, 95% CI 1.24-1.58; and co-dominant effect: TT vs. GG, OR = 1.67, 95% CI 1.37-2.02).	Thioguanine	146-148	dihydrolipoamide S-acetyltransferase	Homo sapiens	74-77
29874129-7	2018	To disrupt RA signaling, Tg(l-fabp:DBP-EGFP:flk1:mCherry) zebrafish were treated with N, N-diethylaminobenzaldehyde and 4-[(1 E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid, which are antagonists of retinal dehydrogenase and the RA receptor, respectively.	Thioguanine	25-27	GC vitamin D binding protein	Danio rerio	35-38
29737518-9	2018	Moreover, miR-181a mimics repressed foam cell formation, TC and TG levels induced by ox-LDL dramatically.	Thioguanine	64-66	microRNA 181a-2	Mus musculus	10-18
29226948-5	2018	Additionally, CD36, oil-red staining levels, TC, and TG were inhibited by miR-182-5p mimics, meanwhile ROS levels, MDA, and cell apoptosis were also restrained with an enhancement of SOD activity.	Thioguanine	53-55	microRNA 182	Mus musculus	74-81
30030379-4	2018	Here, we characterized a transgenic mouse model lacking endogenous Cbs and expressing human p.G307S CBS protein from a zinc-inducible metallothionein promoter (Tg-G307S Cbs-/-).	Thioguanine	160-162	cystathionine beta-synthase	Homo sapiens	169-172
30402207-7	2018	After the establishment of a stable cell line, the upregulation of miR-26a resulted in the downregulation of TG, CL, and MDA levels, through regulating mRNA levels of genes involved in lipid homeostasis, ER stress marker, inflammatory and fibrogenic markers.	Thioguanine	109-111	microRNA 26a-1	Homo sapiens	67-74
30281114-12	2018	Hepatic expression of ceramide synthase 2 was 60% greater after TG infusion compared with the control.	Thioguanine	64-66	ceramide synthase 2	Bos taurus	22-41
30030379-6	2018	In a C3H/HeJ background, zinc-induced Tg-G307S Cbs-/- mice expressed high levels of p.G307S CBS in the liver, and this protein variant forms multimers, similarly to mice expressing WT human CBS.	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	47-50
30030379-4	2018	Here, we characterized a transgenic mouse model lacking endogenous Cbs and expressing human p.G307S CBS protein from a zinc-inducible metallothionein promoter (Tg-G307S Cbs-/-).	Thioguanine	160-162	cystathionine beta-synthase	Homo sapiens	100-103
30030379-6	2018	In a C3H/HeJ background, zinc-induced Tg-G307S Cbs-/- mice expressed high levels of p.G307S CBS in the liver, and this protein variant forms multimers, similarly to mice expressing WT human CBS.	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	92-95
30030379-6	2018	In a C3H/HeJ background, zinc-induced Tg-G307S Cbs-/- mice expressed high levels of p.G307S CBS in the liver, and this protein variant forms multimers, similarly to mice expressing WT human CBS.	Thioguanine	38-40	cystathionine beta-synthase	Homo sapiens	190-193
29600728-8	2018	CT-1 levels were found to be positively correlated with diastolic blood pressure, TG levels and FGS.	Thioguanine	82-84	cardiotrophin 1	Homo sapiens	0-4
30256444-4	2018	The results showed that TG content in cells was significantly decreased, glycerol and free fatty acid were significantly increased in cell culture media, and the expression of phosphorylated ERK1/2 in cells was increased in Chemerin-treated group, suggested that ERK1/2 pathway was involved in regulation of lipolysis by Chemerin.	Thioguanine	24-26	retinoic acid receptor responder 2	Bos taurus	224-232
29920300-0	2018	6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling.	Thioguanine	0-13	Rac family small GTPase 1	Homo sapiens	68-72
29504692-6	2018	The SVR24 rate was lower with unfavorable IL28B rs8099917 SNP genotypes; specifically, the TT, TG and GG had SVR24 rates of 78%, 50% and 40%.	Thioguanine	95-97	interferon lambda 3	Homo sapiens	42-47
30055072-0	2018	A drug-repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6-thioguanine as an effective therapeutic agent for TPMT-low cancer cells.	Thioguanine	90-103	thiopurine S-methyltransferase	Homo sapiens	142-146
30055072-10	2018	We found that TPMT levels were lower in all four PDAC cell lines than in HPDE or Panc1 cells, and that knockdown of TPMT in HPDE or Panc1 cells sensitized them to 6-TG.	Thioguanine	163-167	thiopurine S-methyltransferase	Homo sapiens	116-120
30055072-12	2018	Overall, our study presents 6-TG as a strong candidate for use as a therapeutic agent against PDAC with low levels of TPMT.	Thioguanine	28-32	thiopurine S-methyltransferase	Homo sapiens	118-122
30384541-7	2018	Consequently, the obtained results showed that the contents of the serum TC, TG, LDL-C of low, middle and high-dose PSP groups significantly decreased compared with those of the hyperlipidemia model group.	Thioguanine	77-79	regenerating islet-derived 2	Mus musculus	116-119
30159056-8	2018	Apelin was significantly higher in obese children versus controls and correlated positively with BMI Z-Score (P = 0.008), DBP Z-Score (P = 0.02), cholesterol, TG (both P = 0.02), serum insulin (P = 0.003), FBG and HOMA-IR (both P = 0.001).	Thioguanine	159-161	apelin	Homo sapiens	0-6
30070418-10	2018	Thrombin generation (TG) was reduced in vitro, according to CAT-derived endogenous thrombin potential, but in vivo TG was enhanced in the form of circulating prothrombin fragment 1 and 2 values.	Thioguanine	21-23	coagulation factor II, thrombin	Homo sapiens	0-8
30070418-10	2018	Thrombin generation (TG) was reduced in vitro, according to CAT-derived endogenous thrombin potential, but in vivo TG was enhanced in the form of circulating prothrombin fragment 1 and 2 values.	Thioguanine	21-23	coagulation factor II, thrombin	Homo sapiens	83-91
29920300-7	2018	We have further demonstrated that 6-TG can effectively inhibit the active form of Rac1 (GTP-Rac1), which essentially mediates the anti-rotavirus effect of 6-TG.	Thioguanine	34-38	Rac family small GTPase 1	Homo sapiens	82-86
29920300-7	2018	We have further demonstrated that 6-TG can effectively inhibit the active form of Rac1 (GTP-Rac1), which essentially mediates the anti-rotavirus effect of 6-TG.	Thioguanine	34-38	Rac family small GTPase 1	Homo sapiens	88-96
30089384-3	2018	C16mimPF6 shows a first-order transition between the liquid (L) and liquid crystalline (LC) phases at Tc = 394 K. C8mimPF6 exhibits a glass transition at Tg = 200 K. C9.5mimPF6, which is a 1:3 mixture between C8mimPF6 and C10mimPF6, has both transitions at Tc = 225 K and Tg = 203 K. In the ND experiments, all samples exhibit three peaks corresponding to the correlations mentioned above.	Thioguanine	154-156	sperm associated antigen 17	Homo sapiens	0-9
29920300-7	2018	We have further demonstrated that 6-TG can effectively inhibit the active form of Rac1 (GTP-Rac1), which essentially mediates the anti-rotavirus effect of 6-TG.	Thioguanine	155-159	Rac family small GTPase 1	Homo sapiens	82-86
30089384-3	2018	C16mimPF6 shows a first-order transition between the liquid (L) and liquid crystalline (LC) phases at Tc = 394 K. C8mimPF6 exhibits a glass transition at Tg = 200 K. C9.5mimPF6, which is a 1:3 mixture between C8mimPF6 and C10mimPF6, has both transitions at Tc = 225 K and Tg = 203 K. In the ND experiments, all samples exhibit three peaks corresponding to the correlations mentioned above.	Thioguanine	272-274	sperm associated antigen 17	Homo sapiens	0-9
29920300-7	2018	We have further demonstrated that 6-TG can effectively inhibit the active form of Rac1 (GTP-Rac1), which essentially mediates the anti-rotavirus effect of 6-TG.	Thioguanine	155-159	Rac family small GTPase 1	Homo sapiens	88-96
29920300-9	2018	In conclusion, we have identified 6-TG as an effective inhibitor of rotavirus replication via the inhibition of Rac1 activation.	Thioguanine	34-38	Rac family small GTPase 1	Homo sapiens	112-116
29806965-6	2018	The results showed that THP could decrease the blood glucose, TC, TG, LDL-C levels, increase the body weight, HDL-C, insulin levels, and enhance the activities of antioxidant enzyme system in alloxan-induced diabetic mice.	Thioguanine	66-68	uromodulin	Mus musculus	24-27
29844120-2	2018	One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6"-thioguanine (6TG) or 2"-fluoroadenine (2FA) with the MTAP substrate 5"-deoxy-5"-methylthioadenosine (MTA).	Thioguanine	115-129	methylthioadenosine phosphorylase	Homo sapiens	45-49
29844120-5	2018	Here, we examine the effects of 6TG and 2FA in combination with MTA in vitro and in vivoIn vitro, MTA protected against both 6TG and 2FA toxicity in an MTAP-dependent manner, shifting the IC50 concentration by one to three orders of magnitude.	Thioguanine	32-35	methylthioadenosine phosphorylase	Homo sapiens	152-156
29844120-2	2018	One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6"-thioguanine (6TG) or 2"-fluoroadenine (2FA) with the MTAP substrate 5"-deoxy-5"-methylthioadenosine (MTA).	Thioguanine	131-134	methylthioadenosine phosphorylase	Homo sapiens	45-49
27652568-8	2018	Within the patient group, there was a significant negative correlation between serum irisin and serum TG, LDL, and TG/HDL levels (P=0.041, P=0.022, P=0.025), and a positive correlation with HDL levels (P=0.036).	Thioguanine	102-104	fibronectin type III domain containing 5	Homo sapiens	85-91
29672446-8	2018	Both Abeta plaques and soluble forms of Abeta (Abeta40 and Abeta42) were significantly increased in TG-SED mice compared with WT-SED mice, whereas exercise reduced Abeta deposition in APP/PS1 transgenic mice.	Thioguanine	100-102	amyloid beta (A4) precursor protein	Mus musculus	5-10
30012901-2	2018	In TGCV, adipose triglyceride lipase (ATGL) deficiency results in the abnormal intracellular metabolism of long-chain fatty acid (LCFA) which leads to TG deposition.	Thioguanine	3-5	patatin-like phospholipase domain containing 2	Mus musculus	9-36
30012901-2	2018	In TGCV, adipose triglyceride lipase (ATGL) deficiency results in the abnormal intracellular metabolism of long-chain fatty acid (LCFA) which leads to TG deposition.	Thioguanine	3-5	patatin-like phospholipase domain containing 2	Mus musculus	38-42
30349895-10	2018	A large inter-individual variability (peak CV 31%, range 73-220 nmol/L thrombin) in saliva-induced TG was observed.	Thioguanine	99-101	coagulation factor II, thrombin	Homo sapiens	71-79
30349895-11	2018	Interestingly, within subjects, saliva-induced TG was significantly (P = 0.009) increased in the morning (167 +- 40 nmol/L thrombin) compared to the afternoon (124 +- 39 nmol/L thrombin) and evening (123 +- 38 nmol/L thrombin).	Thioguanine	47-49	coagulation factor II, thrombin	Homo sapiens	123-131
30349895-11	2018	Interestingly, within subjects, saliva-induced TG was significantly (P = 0.009) increased in the morning (167 +- 40 nmol/L thrombin) compared to the afternoon (124 +- 39 nmol/L thrombin) and evening (123 +- 38 nmol/L thrombin).	Thioguanine	47-49	coagulation factor II, thrombin	Homo sapiens	177-185
30349895-11	2018	Interestingly, within subjects, saliva-induced TG was significantly (P = 0.009) increased in the morning (167 +- 40 nmol/L thrombin) compared to the afternoon (124 +- 39 nmol/L thrombin) and evening (123 +- 38 nmol/L thrombin).	Thioguanine	47-49	coagulation factor II, thrombin	Homo sapiens	177-185
29672446-8	2018	Both Abeta plaques and soluble forms of Abeta (Abeta40 and Abeta42) were significantly increased in TG-SED mice compared with WT-SED mice, whereas exercise reduced Abeta deposition in APP/PS1 transgenic mice.	Thioguanine	100-102	amyloid beta (A4) precursor protein	Mus musculus	40-45
29672446-8	2018	Both Abeta plaques and soluble forms of Abeta (Abeta40 and Abeta42) were significantly increased in TG-SED mice compared with WT-SED mice, whereas exercise reduced Abeta deposition in APP/PS1 transgenic mice.	Thioguanine	100-102	amyloid beta (A4) precursor protein	Mus musculus	40-45
29996605-9	2018	BNP: BNP in HFG and TG were much higher than that in NG (P&lt;0.05), TG was significantly lower than HFG (P&lt;0.05).	Thioguanine	20-22	natriuretic peptide type B	Mus musculus	0-3
29864903-6	2018	The data suggest that combined treatment with EPA and ATM is beneficial to endothelial function and was unique to EPA and ATM since similar improvements could not be recapitulated by substituting another O3FA docosahexaenoic acid (DHA) or other TG-lowering agents such as fenofibrate, niacin, or gemfibrozil.	Thioguanine	245-247	ATM serine/threonine kinase	Homo sapiens	54-57
29973208-6	2018	RESULTS: Six candidate gene biomarkers (MX1, OASL, SPINK1, CRK, GRAPL and RNF2) were identified to be predictors of TG therapy.	Thioguanine	116-118	MX dynamin like GTPase 1	Homo sapiens	40-43
29973208-6	2018	RESULTS: Six candidate gene biomarkers (MX1, OASL, SPINK1, CRK, GRAPL and RNF2) were identified to be predictors of TG therapy.	Thioguanine	116-118	2'-5'-oligoadenylate synthetase like	Homo sapiens	45-49
29973208-6	2018	RESULTS: Six candidate gene biomarkers (MX1, OASL, SPINK1, CRK, GRAPL and RNF2) were identified to be predictors of TG therapy.	Thioguanine	116-118	serine peptidase inhibitor Kazal type 1	Homo sapiens	51-57
29973208-6	2018	RESULTS: Six candidate gene biomarkers (MX1, OASL, SPINK1, CRK, GRAPL and RNF2) were identified to be predictors of TG therapy.	Thioguanine	116-118	CRK proto-oncogene, adaptor protein	Homo sapiens	59-62
29973208-6	2018	RESULTS: Six candidate gene biomarkers (MX1, OASL, SPINK1, CRK, GRAPL and RNF2) were identified to be predictors of TG therapy.	Thioguanine	116-118	GRB2 related adaptor protein like	Homo sapiens	64-69
30141439-14	2018	In multivariate logistic regression analysis that adjusted for confounders of HDL-C level (age, sex, smoking, hypertension, TC, LDL-C, TG) associated with ACS.	Thioguanine	135-137	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	155-158
29973208-6	2018	RESULTS: Six candidate gene biomarkers (MX1, OASL, SPINK1, CRK, GRAPL and RNF2) were identified to be predictors of TG therapy.	Thioguanine	116-118	ring finger protein 2	Homo sapiens	74-78
29302702-5	2018	In the cortex and hippocampus of Furin-Tg mice, the ratio of mature brain-derived neurotrophic factor (mBDNF) to pro-BDNF, and the activities of extracellular signal-related kinase (ERK) and cAMP response element-binding protein (CREB) were significantly elevated.	Thioguanine	39-41	furin (paired basic amino acid cleaving enzyme)	Mus musculus	33-38
29699923-4	2018	DGAT1 knockout mice could survive and displayed a reduction in the postprandial rise of plasma TG, and increased sensitivity of insulin and leptin.	Thioguanine	95-97	diacylglycerol O-acyltransferase 1	Mus musculus	0-5
30111035-1	2018	To evaluate the clinical efficacy and safety of tripterygium glycosides (TG) in the treatment of henoch-schonlein purpura nephritis(HSPN).	Thioguanine	73-75	heat shock protein 90 alpha family class A member 1	Homo sapiens	132-136
29922222-10	2018	Furthermore, anxiety and depression levels were enhanced in WT mice exposed to IH as compared to RA controls, while alterations emerged in Ngb-TG mice exposed to IH.	Thioguanine	143-145	neuroglobin	Mus musculus	139-142
29581016-3	2018	RESULTS: The polymorphisms rs4968451T&gt;G in BRIP1 were significantly associated with the risk of meningioma (TT vs. TG vs. GG additive, P = 0.005; TT+TG vs. GG dominant, P = 0.015; TT/GT+GG recessive, P = 0.034).	Thioguanine	118-120	BRCA1 interacting helicase 1	Homo sapiens	46-51
29608911-0	2018	Renal aquaporin-4 associated pathology in TG-26 mice.	Thioguanine	42-44	aquaporin 4	Mus musculus	6-17
28733897-5	2018	We observed that expression of APP and beta-secretase as well as production of total Abeta and Abeta42 were significantly reduced in APP transgenic mice lacking CB2R (TG-CB2-KO) treated with JZL184, a selective and potent inhibitor for MAGL.	Thioguanine	167-169	cannabinoid receptor 2 (macrophage)	Mus musculus	161-165
28733897-5	2018	We observed that expression of APP and beta-secretase as well as production of total Abeta and Abeta42 were significantly reduced in APP transgenic mice lacking CB2R (TG-CB2-KO) treated with JZL184, a selective and potent inhibitor for MAGL.	Thioguanine	167-169	cannabinoid receptor 2 (macrophage)	Mus musculus	161-164
28733897-5	2018	We observed that expression of APP and beta-secretase as well as production of total Abeta and Abeta42 were significantly reduced in APP transgenic mice lacking CB2R (TG-CB2-KO) treated with JZL184, a selective and potent inhibitor for MAGL.	Thioguanine	167-169	monoglyceride lipase	Mus musculus	236-240
29581016-3	2018	RESULTS: The polymorphisms rs4968451T&gt;G in BRIP1 were significantly associated with the risk of meningioma (TT vs. TG vs. GG additive, P = 0.005; TT+TG vs. GG dominant, P = 0.015; TT/GT+GG recessive, P = 0.034).	Thioguanine	152-154	BRCA1 interacting helicase 1	Homo sapiens	46-51
29581016-4	2018	The significant association was found only in females for BRIP1 rs4968451T&gt;G (TT+TG vs. GG dominant, P = 0.001; TT/GT+GG recessive, P = 0.044).	Thioguanine	84-86	BRCA1 interacting helicase 1	Homo sapiens	58-63
29407924-3	2018	100 microM CLA-TG nanoemulsion significantly reduced fat accumulation by 29% compared to linoleic acid (LA)-TG treatment via sir-2.1 (the ortholog of Sirtuin 1), without altering the worm size, growth rate, and pumping rate of C. elegans.	Thioguanine	108-110	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	125-132
29567833-9	2018	In summary, our results suggest that in addition to mCG sites, unmethylated CA or TG sites also serve as DNA-binding sites for MeCP2 and other MBD-containing proteins.	Thioguanine	82-84	methyl-CpG binding protein 2	Homo sapiens	127-132
29888290-7	2018	Significant positive correlations of VDBP clearance ratio were found with age, WC, SBP, DBP, TG, glucose, HbA1c, urine VDBP, urine microalbumin, and urine microalbumin/creatinine, and a significant negative correlation was found with the steady-state estimate of beta cell function (B%).	Thioguanine	93-95	GC vitamin D binding protein	Homo sapiens	37-41
29888290-7	2018	Significant positive correlations of VDBP clearance ratio were found with age, WC, SBP, DBP, TG, glucose, HbA1c, urine VDBP, urine microalbumin, and urine microalbumin/creatinine, and a significant negative correlation was found with the steady-state estimate of beta cell function (B%).	Thioguanine	93-95	D-box binding PAR bZIP transcription factor	Homo sapiens	38-41
30083334-8	2018	Notably, necrostatin-1, the specific inhibitor of the RIP3 signaling pathway, and 6-thioguanine (6-TG), the active metabolite of azathioprine, predominantly reduced IL-6 production compared to other cytokines.	Thioguanine	82-95	interleukin 6	Homo sapiens	165-169
30083334-8	2018	Notably, necrostatin-1, the specific inhibitor of the RIP3 signaling pathway, and 6-thioguanine (6-TG), the active metabolite of azathioprine, predominantly reduced IL-6 production compared to other cytokines.	Thioguanine	97-101	interleukin 6	Homo sapiens	165-169
30083334-10	2018	Conclusions: RIP3 signaling is involved in macrophage/monocyte activation in AIH and mediates IL-6 production, and is a novel molecular mechanism of 6-TG, indicating that it might be a promising therapeutic target for AIH treatment.	Thioguanine	149-153	receptor interacting serine/threonine kinase 3	Homo sapiens	13-17
29785900-10	2018	These results indicate that insulin inhibits the AMPKalpha signaling pathway to increase lipid synthesis and decrease lipid oxidation and VLDL assembly in cow hepatocytes, thereby inducing TG accumulation.	Thioguanine	189-191	insulin	Bos taurus	28-35
29449434-4	2018	We knocked down MSH6 in mismatch repair proficient cell lines (697 and UOCB1) and showed significant increases in IC50s to 6-thioguanine and 6-mercaptopurine (697: 26- and 9-fold; UOCB1: 5- and 8-fold) in vitro, as well as increased resistance to 6-mercaptopurine treatment in vivo No shift in IC50 was observed in deficient cells (Reh and RS4;11).	Thioguanine	123-136	mutS homolog 6	Homo sapiens	16-20
29666426-5	2018	In response to MI, infarct size in adult (16-week old) dn-c-kit-Tg hearts was similar to that of NTL after 24 h but was half that in NTL hearts 12 weeks post-MI.	Thioguanine	64-66	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	58-63
29609455-2	2018	Here, for the first time, for PIM-1, as the archetypal PIM, fast scanning calorimetry provides definitive evidence of a glass transition ( Tg = 715 K, heating rate 3 x 104 K/s) by decoupling the time scales responsible for glass transition and decomposition.	Thioguanine	139-141	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	30-35
29609455-2	2018	Here, for the first time, for PIM-1, as the archetypal PIM, fast scanning calorimetry provides definitive evidence of a glass transition ( Tg = 715 K, heating rate 3 x 104 K/s) by decoupling the time scales responsible for glass transition and decomposition.	Thioguanine	139-141	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	30-33
29672573-10	2018	The double fluorochrome labeling analyses demonstrated that the dentin mineral deposition rate in the Dspp-/-;DPP Tg mice was significantly improved compared to that in the Dspp-null mice.	Thioguanine	114-116	dentin sialophosphoprotein	Mus musculus	102-106
29672573-10	2018	The double fluorochrome labeling analyses demonstrated that the dentin mineral deposition rate in the Dspp-/-;DPP Tg mice was significantly improved compared to that in the Dspp-null mice.	Thioguanine	114-116	dentin sialophosphoprotein	Mus musculus	110-113
29731736-13	2018	In patients selected for the lowest FXII:ratio, TG triggered by ellagic acid showed a trend in lower endogenous thrombin potential (ETP) in MS patients compared with HS (p = 0.042).	Thioguanine	48-50	coagulation factor II, thrombin	Homo sapiens	112-120
29642854-4	2018	RESULTS: In response to the intraventricular injection of 40 ng and 400 ng visfatin, feed intake in chicks was significantly increased, and the concentrations of glucose, insulin, TG, HDL and LDL were significantly altered.	Thioguanine	180-182	nicotinamide phosphoribosyltransferase pseudogene 1	Gallus gallus	75-83
29686595-5	2018	The distribution of the adiponectin 45T/G polymorphism was 3.56% (n = 27) for GG, 42.35% (n = 321) for TG, and 54.09% (n = 410) for TT in patients with type 2 diabetes.	Thioguanine	103-105	adiponectin, C1Q and collagen domain containing	Homo sapiens	24-35
29091793-0	2018	Differential sensitivities to dioxin-like compounds PCB 126 and PeCDF between Tg(cyp1a:gfp) transgenic medaka and zebrafish larvae.	Thioguanine	78-80	cytochrome P450 1A1	Oryzias latipes	81-86
31149268-1	2018	Context: Despite that the Triglycerides/High Density Lipoprotein Cholesterol (TG/HDL-C) ratio has been associated with insulin resistance and cardiovascular disease, some outcomes differ between populations.	Thioguanine	78-80	insulin	Homo sapiens	119-126
29378206-8	2018	Consistent with these results, PSRC1 overexpression in apoE-/- mice decreased the plasma levels of TC, TG, LDL-C, TNF-alpha, IL-1beta and IL-6, increased the plasma HDL-C levels and improved HDL function.	Thioguanine	103-105	proline/serine-rich coiled-coil 1	Mus musculus	31-36
29378206-8	2018	Consistent with these results, PSRC1 overexpression in apoE-/- mice decreased the plasma levels of TC, TG, LDL-C, TNF-alpha, IL-1beta and IL-6, increased the plasma HDL-C levels and improved HDL function.	Thioguanine	103-105	apolipoprotein E	Mus musculus	55-59
29903275-7	2018	KCNJ11 gene polymorphism analysis showed that the TG, TC and HDL-C lipid metabolism indexes of CC genotype in rs5219 locus were more significant than those of TT and CT genotypes(t=2.	Thioguanine	50-52	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	0-6
29495235-9	2018	Conclusions: Apo A5 significantly reduced intracellular TG content and modulated the gene expression levels of adipogenic differentiation marker, thus, Apo A5 treatment can inhibit the adipogenic differentiation of adipose mesenchymal stem cells.	Thioguanine	56-58	apolipoprotein A5	Homo sapiens	13-19
29495235-9	2018	Conclusions: Apo A5 significantly reduced intracellular TG content and modulated the gene expression levels of adipogenic differentiation marker, thus, Apo A5 treatment can inhibit the adipogenic differentiation of adipose mesenchymal stem cells.	Thioguanine	56-58	apolipoprotein A5	Homo sapiens	152-158
29520298-8	2018	Out of these, the LD-block 3 in calpastatin, tagged by SNPs located at 7-98566391 and 7-98581038, had a significant effect on tenderness with the TG-CG diplotype being approximately 1 kg more tender than the toughest diplotype, TG-CG.	Thioguanine	146-148	calpastatin	Bos taurus	32-43
29520298-8	2018	Out of these, the LD-block 3 in calpastatin, tagged by SNPs located at 7-98566391 and 7-98581038, had a significant effect on tenderness with the TG-CG diplotype being approximately 1 kg more tender than the toughest diplotype, TG-CG.	Thioguanine	228-230	calpastatin	Bos taurus	32-43
29398545-1	2018	LXRbeta-selective agonists are promising candidates to improve atherosclerosis without increasing plasma or hepatic TG levels.	Thioguanine	116-118	nuclear receptor subfamily 1 group H member 2	Homo sapiens	0-7
28499789-8	2018	RESULTS: There were significant differences in genotype frequencies of eNOS Glu298Asp polymorphism between case and control groups (GG+TG vs. TT; p=0.002; OR=0.22, 95% CI 0.83 to 0.62).	Thioguanine	135-137	nitric oxide synthase 3	Homo sapiens	71-75
29745912-8	2018	Intensive treatment of both conditions with diet, physical activity, fenofibrates and insulin is important, as it aims to reduce TG values and normalize glucose profile.	Thioguanine	129-131	insulin	Homo sapiens	86-93
29614587-11	2018	However, 6-TG inhibits peptidoglycan-induced activation of Rac1 signaling pathway leading to macrophage apoptosis.	Thioguanine	9-13	Rac family small GTPase 1	Homo sapiens	59-63
28976243-4	2018	In our recent Gut paper, we showed that thioguanine worked quickly to improve colitis in the absence in the host animal of the key guanine salvage enzyme, hypoxanthine-guanine-phosphoribosyltransferase (HPRT).	Thioguanine	40-51	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	155-201
28976243-4	2018	In our recent Gut paper, we showed that thioguanine worked quickly to improve colitis in the absence in the host animal of the key guanine salvage enzyme, hypoxanthine-guanine-phosphoribosyltransferase (HPRT).	Thioguanine	40-51	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	203-207
29407885-2	2018	The objective of this study was to examine how the pre-LA serum TG concentrations influence the efficacy of LA to acutely reduce LDL-C and Lp(a) concentrations in HoFH patients.	Thioguanine	64-66	lipoprotein(a)	Homo sapiens	139-144
29449607-0	2018	6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.	Thioguanine	0-13	ubiquitin specific peptidase 2	Homo sapiens	96-100
29449607-4	2018	Here a leukemia drug, 6-thioguanine, was found to be a potent inhibitor of USP2.	Thioguanine	22-35	ubiquitin specific peptidase 2	Homo sapiens	75-79
29449607-5	2018	Enzyme-kinetic and X-ray crystallographic data suggest that 6-thioguanine displays a noncompetitive and slow-binding inhibitory mechanism against USP2.	Thioguanine	60-73	ubiquitin specific peptidase 2	Homo sapiens	146-150
29449607-6	2018	Our study provides a clear rationale for the clinical evaluation of 6-thioguanine for USP2-upregulated cancers.	Thioguanine	68-81	ubiquitin specific peptidase 2	Homo sapiens	86-90
28866090-11	2018	In women, there was a significant correlation between AST level and serum TG (r=0.15, P&lt;0.05).	Thioguanine	74-76	solute carrier family 17 member 5	Homo sapiens	54-57
28866090-12	2018	A significant positive and negative correlation were found respectively between serum ALT and AST/ALT ratio and waist circumference, serum TG and fasting blood glucose.	Thioguanine	139-141	solute carrier family 17 member 5	Homo sapiens	94-97
29245159-9	2018	SHBG correlated with age, BMI, TG, HDL, TT, free testosterone, and bio-available testosterone.	Thioguanine	31-33	sex hormone binding globulin	Homo sapiens	0-4
29412368-10	2018	In addition, the proportion of individuals with adequate tone of lower lip and adequate tongue mobility for TG increased significantly from P1 and P2 in relation to P0.	Thioguanine	108-110	crystallin gamma F, pseudogene	Homo sapiens	140-149
28409836-11	2018	PMP-induced TG attenuated in FXII- and FVII-deficient plasma.	Thioguanine	12-14	coagulation factor XII (Hageman factor)	Mus musculus	29-34
29358304-8	2018	RESULTS: AMHrs10407022T&gt;G was associated with higher serum levels of AMH in prepubertal boys (TT: 575 pmol/L vs TG: 633 pmol/L vs GG: 837 pmol/L, P = 0.002) and adolescents (TT: 44 pmol/L vs TG: 58 pmol/L vs GG: 79 pmol/L, P &lt; 0.001).	Thioguanine	115-117	anti-Mullerian hormone	Homo sapiens	9-12
29358304-8	2018	RESULTS: AMHrs10407022T&gt;G was associated with higher serum levels of AMH in prepubertal boys (TT: 575 pmol/L vs TG: 633 pmol/L vs GG: 837 pmol/L, P = 0.002) and adolescents (TT: 44 pmol/L vs TG: 58 pmol/L vs GG: 79 pmol/L, P &lt; 0.001).	Thioguanine	194-196	anti-Mullerian hormone	Homo sapiens	9-12
27848227-6	2018	Glomerular C3d and C4d deposition occurred in a distinct pattern in all TG biopsies: segmental or global double linear staining of the glomerular capillary wall in 23 (100%).	Thioguanine	72-74	endogenous retrovirus group K member 13	Homo sapiens	11-14
29568353-8	2018	In addition, we found that ACSS2 inhibition greatly perturbed levels of metabolites, including CE(18:1), CE(22:6), TG(49:1), and TG(53:2).	Thioguanine	115-117	acyl-CoA synthetase short chain family member 2	Homo sapiens	27-32
29128404-10	2018	No differences in ZO-1 relative expression patterns were observed in cultured cells, with increased expression in IL-6 in cells exposed to nTg milk than controls, with the Tg group being similar to all groups.	Thioguanine	140-142	interleukin 6	Homo sapiens	114-118
29350678-5	2018	By contrast, hepatic PIK3R3 knockout in normal mice led to increased hepatic TG levels.	Thioguanine	77-79	phosphoinositide-3-kinase regulatory subunit 3	Mus musculus	21-27
29568353-8	2018	In addition, we found that ACSS2 inhibition greatly perturbed levels of metabolites, including CE(18:1), CE(22:6), TG(49:1), and TG(53:2).	Thioguanine	129-131	acyl-CoA synthetase short chain family member 2	Homo sapiens	27-32
28945288-4	2018	RAD51D is an important component of homologous recombination (HR), and our previous work established that mammalian cells defective for RAD51D are more sensitive to the thiopurine 6-thioguanine (6TG) and have dramatically increased numbers of multinucleated cells and chromosome instability.	Thioguanine	195-198	RAD51 paralog D	Homo sapiens	0-6
29069580-7	2018	In the liver, the expression and activity of G6PD increased along with the GSSG, TBARS, and TG concentrations.	Thioguanine	92-94	glucose-6-phosphate dehydrogenase	Rattus norvegicus	45-49
28945288-4	2018	RAD51D is an important component of homologous recombination (HR), and our previous work established that mammalian cells defective for RAD51D are more sensitive to the thiopurine 6-thioguanine (6TG) and have dramatically increased numbers of multinucleated cells and chromosome instability.	Thioguanine	195-198	RAD51 paralog D	Homo sapiens	136-142
29862308-4	2018	Insertion of the 3xFLAG-mIR transgene into FVB/NJ mice, a known non-autoimmune prone strain, lead to a minor population of detectable 3xFLAG-mIR tagged T-lymphocytes in peripheral blood and the presence of a few lymphocytes in the pancreas of the Tg+/- compared to age matched Tg-/- control mice.	Thioguanine	247-249	microRNA 615	Mus musculus	24-27
29862308-4	2018	Insertion of the 3xFLAG-mIR transgene into FVB/NJ mice, a known non-autoimmune prone strain, lead to a minor population of detectable 3xFLAG-mIR tagged T-lymphocytes in peripheral blood and the presence of a few lymphocytes in the pancreas of the Tg+/- compared to age matched Tg-/- control mice.	Thioguanine	247-249	microRNA 615	Mus musculus	141-144
29283382-6	2017	Enzyme assays confirmed the thiopurine leukaemia drug, thioguanine, as a tyrosinase inhibitor with the inhibitory constant of 52 muM.	Thioguanine	55-66	tyrosinase	Homo sapiens	73-83
29913451-2	2018	HTG in CKD is caused mainly by the decreased efficiency of lipoprotein lipase (LPL)-mediated very low density lipoprotein triglyceride (VLDL-TG) lipolysis.	Thioguanine	1-3	lipoprotein lipase	Homo sapiens	59-77
29913451-2	2018	HTG in CKD is caused mainly by the decreased efficiency of lipoprotein lipase (LPL)-mediated very low density lipoprotein triglyceride (VLDL-TG) lipolysis.	Thioguanine	1-3	lipoprotein lipase	Homo sapiens	79-82
29913451-9	2018	The positive impact of HDL on VLDL lipolysis was modified by CKD progression: the percentage of lipolyzed VLDL-TG in the presence of HDL decreased with a reduction in eGFR (r=0.43, p=0.009), and for patients with stage 4 CKD, no positive impact of HDL on lipolysis was observed.	Thioguanine	111-113	epidermal growth factor receptor	Homo sapiens	167-171
29283382-6	2017	Enzyme assays confirmed the thiopurine leukaemia drug, thioguanine, as a tyrosinase inhibitor with the inhibitory constant of 52 muM.	Thioguanine	55-66	latexin	Homo sapiens	129-132
29283382-10	2017	Particularly, 50 muM thioguanine reduced the melanin content by 57%, without apparent cytotoxicity.	Thioguanine	21-32	latexin	Homo sapiens	17-20
29964561-2	2017	It was found that the levels of THg, dissolved mercury, and particulate mercury in the water ranged from 1.65-9.65, 0.80-3.16, and 0.70-7.81 ng L-1, respectively.	Thioguanine	32-35	immunoglobulin kappa variable 1-16	Homo sapiens	144-147
32264536-5	2017	The ex vivo results indicated that THG directly promoted cell proliferation of peritoneal macrophages, whole spleen cells and lymphocytes, and activated peritoneal macrophages with TNF-alpha production.	Thioguanine	35-38	tumor necrosis factor	Mus musculus	181-190
29018079-3	2017	SETD2 mutations led to resistance to DNA-damaging agents, cytarabine, 6-thioguanine, doxorubicin, and etoposide, but not to a non-DNA damaging agent, l-asparaginase.	Thioguanine	70-83	SET domain containing 2	Mus musculus	0-5
28751218-6	2017	Indeed, the identification of lipoprotein lipase (LPL) in the brain has led to the hypothesis that the LPL-dependent degradation of TG-enriched particles, and the addition of fatty acids, as informative molecules, to sensitive cells (neurons and/or astrocytes), plays a key role in maintaining the energy balance at equilibrium.	Thioguanine	132-134	lipoprotein lipase	Homo sapiens	30-48
29212537-5	2017	RESULTS: In 81 patients who completed 12-month anti-VEGF monotherapy without photodynamic therapy, significant pharmacogenetic association was found between ARMS2 rs10490924 and PED regression on OCT. Proportions of PED regression were 26.4% for TT, 45.7% for TG, and 63.6% for GG genotype, showing additive effect of G allele for higher chance of PED regression (OR, 2.96; 95% CI, 1.38-6.36; corrected P = 0.043).	Thioguanine	260-262	vascular endothelial growth factor A	Homo sapiens	52-56
29212537-5	2017	RESULTS: In 81 patients who completed 12-month anti-VEGF monotherapy without photodynamic therapy, significant pharmacogenetic association was found between ARMS2 rs10490924 and PED regression on OCT. Proportions of PED regression were 26.4% for TT, 45.7% for TG, and 63.6% for GG genotype, showing additive effect of G allele for higher chance of PED regression (OR, 2.96; 95% CI, 1.38-6.36; corrected P = 0.043).	Thioguanine	260-262	age-related maculopathy susceptibility 2	Homo sapiens	157-162
28751218-6	2017	Indeed, the identification of lipoprotein lipase (LPL) in the brain has led to the hypothesis that the LPL-dependent degradation of TG-enriched particles, and the addition of fatty acids, as informative molecules, to sensitive cells (neurons and/or astrocytes), plays a key role in maintaining the energy balance at equilibrium.	Thioguanine	132-134	lipoprotein lipase	Homo sapiens	50-53
28751218-6	2017	Indeed, the identification of lipoprotein lipase (LPL) in the brain has led to the hypothesis that the LPL-dependent degradation of TG-enriched particles, and the addition of fatty acids, as informative molecules, to sensitive cells (neurons and/or astrocytes), plays a key role in maintaining the energy balance at equilibrium.	Thioguanine	132-134	lipoprotein lipase	Homo sapiens	103-106
28901011-11	2017	Treatment with ethosuximide significantly blocks seizures in both stg/stg and tg/tg, but the abnormal PAC remains.	Thioguanine	71-73	RIKEN cDNA 2300002M23 gene	Mus musculus	66-69
28948298-10	2017	beta-catenin, Bcl-2, and VEGF (vascular endothelial growth factor) were upregulated while APC, p16, and caspase-3 were downregulated in 210-TG hearts.	Thioguanine	140-142	catenin (cadherin associated protein), beta 1	Mus musculus	0-12
28948298-10	2017	beta-catenin, Bcl-2, and VEGF (vascular endothelial growth factor) were upregulated while APC, p16, and caspase-3 were downregulated in 210-TG hearts.	Thioguanine	140-142	B cell leukemia/lymphoma 2	Mus musculus	14-19
28948298-10	2017	beta-catenin, Bcl-2, and VEGF (vascular endothelial growth factor) were upregulated while APC, p16, and caspase-3 were downregulated in 210-TG hearts.	Thioguanine	140-142	APC, WNT signaling pathway regulator	Mus musculus	90-93
28948615-2	2017	Here, we reported that in human hepatoma SK-Hep-1 and HepG2 cells, NDRG2 mRNA and protein levels were upregulated by different endoplasmic reticulum stress inducers including Tg, Tm, and DTT.	Thioguanine	175-177	NDRG family member 2	Homo sapiens	67-72
28948298-10	2017	beta-catenin, Bcl-2, and VEGF (vascular endothelial growth factor) were upregulated while APC, p16, and caspase-3 were downregulated in 210-TG hearts.	Thioguanine	140-142	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	95-98
28948298-10	2017	beta-catenin, Bcl-2, and VEGF (vascular endothelial growth factor) were upregulated while APC, p16, and caspase-3 were downregulated in 210-TG hearts.	Thioguanine	140-142	caspase 3	Mus musculus	104-113
28917663-3	2017	Immunostaining and Western blotting revealed age-related increase in LRG expression in hippocampal neurons in 8-, 24-, and 48-week-old controls and LRG-Tg.	Thioguanine	152-154	leucine rich alpha-2-glycoprotein 1	Homo sapiens	148-151
29750183-10	2018	In multiple regression analysis, adiponectin showed a positive association with the epicardial C24:1omega9 concentration after controlling for age and BMI, or TG, non-HDL-C, and BNP.	Thioguanine	159-161	adiponectin, C1Q and collagen domain containing	Homo sapiens	33-44
27613563-2	2017	We investigated the effect of Ramadan fasting on thrombin generation (TG) in patients with cardiovascular disease (CVD) risks, and we aimed to assess the effect of lipid profile on TG parameters.	Thioguanine	70-72	coagulation factor II, thrombin	Homo sapiens	49-57
27989516-8	2017	CONCLUSION: Thus, it appears that high fat is related to the high blood concentration of TG in older people aged &gt;=80 years, especially those with Asian origin and diabetes besides those with low muscle mass shows lower mean values of LDL-c.	Thioguanine	89-91	component of oligomeric golgi complex 2	Homo sapiens	238-243
28911876-9	2017	RESULTS: In this retrospective analysis of 24 KTxRs with TG, 16/24 (67%) patients with biopsy-proven TG developed Abs to vimentin (645+-427ng/ml).	Thioguanine	57-59	vimentin	Homo sapiens	121-129
28911876-9	2017	RESULTS: In this retrospective analysis of 24 KTxRs with TG, 16/24 (67%) patients with biopsy-proven TG developed Abs to vimentin (645+-427ng/ml).	Thioguanine	101-103	vimentin	Homo sapiens	121-129
28911876-11	2017	Of the patients with TG, 15/24 (63%) developed Abs to vimentin of IgG isotype (572+-276ng/ml), whereas only 6/24 (25%) stable KTxRs (310+-288ng/ml) had anti-vimentin of IgG isotype (p=0.002).	Thioguanine	21-23	vimentin	Homo sapiens	54-62
29065178-8	2017	As an example of a biological application, THG was used as a label-free imaging technique to study structural variations in the LCN of live mice deficient in both histone deacetylase 4 and 5 (HDAC4, HDAC5).	Thioguanine	43-46	histone deacetylase 4	Mus musculus	163-190
29077063-6	2017	The sarco/endoplasmic reticulum Ca2+-ATPase inhibitor thasigargin (Tg) responses to the maximal ATP concentration (100 muM) in THP-1 monocytes, and responses in macrophage were significantly attenuated.	Thioguanine	67-69	GLI family zinc finger 2	Homo sapiens	127-132
29077063-10	2017	shRNA-mediated P2X4 knockdown resulted in a significant reduction in Tg-resistant ATP-evoked calcium response as well as reduced sensitivities towards P2X4-specific pharmacological tools, IVM and PSB-12062.	Thioguanine	69-71	purinergic receptor P2X 4	Homo sapiens	15-19
29065178-8	2017	As an example of a biological application, THG was used as a label-free imaging technique to study structural variations in the LCN of live mice deficient in both histone deacetylase 4 and 5 (HDAC4, HDAC5).	Thioguanine	43-46	histone deacetylase 4	Mus musculus	192-197
29065178-8	2017	As an example of a biological application, THG was used as a label-free imaging technique to study structural variations in the LCN of live mice deficient in both histone deacetylase 4 and 5 (HDAC4, HDAC5).	Thioguanine	43-46	histone deacetylase 5	Mus musculus	199-204
28966507-1	2017	BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine.	Thioguanine	158-171	thiopurine S-methyltransferase	Homo sapiens	12-42
28966327-7	2017	Cardiac function, angiogenesis, and VEGF expression were impaired in the diabetic TG mice, but they were ameliorated by the DPP4 inhibition to levels similar to those found in the non-diabetic TG mice.The DPP4 inhibitor ameliorated cardiac function by inhibiting the inactivation of HMGB1 in diabetic mice after MI.	Thioguanine	193-195	dipeptidylpeptidase 4	Mus musculus	124-128
28966327-7	2017	Cardiac function, angiogenesis, and VEGF expression were impaired in the diabetic TG mice, but they were ameliorated by the DPP4 inhibition to levels similar to those found in the non-diabetic TG mice.The DPP4 inhibitor ameliorated cardiac function by inhibiting the inactivation of HMGB1 in diabetic mice after MI.	Thioguanine	193-195	dipeptidylpeptidase 4	Mus musculus	205-209
28494367-4	2017	The light scattered by target protein (CEA)-bound 20-nm silver nanoparticles (plasmonic nanoprobes) was collected and spectrally isolated in first-order spectral images (n=+1) by a TG (70 grooves/mm).	Thioguanine	181-183	CEA cell adhesion molecule 3	Homo sapiens	39-42
28966327-5	2017	The HMGB1 plasma levels were reduced in the diabetic TG compared with the non-diabetic TG mice, but DPP4 inhibition with anagliptin increased HMGB1 plasma levels in the diabetic TG mice.	Thioguanine	53-55	high mobility group box 1	Mus musculus	4-9
28966327-6	2017	The infarct area was significantly larger in the diabetic TG than in the non-diabetic TG mice, and it was reduced by DPP4 inhibition.	Thioguanine	58-60	dipeptidylpeptidase 4	Mus musculus	117-121
28966327-7	2017	Cardiac function, angiogenesis, and VEGF expression were impaired in the diabetic TG mice, but they were ameliorated by the DPP4 inhibition to levels similar to those found in the non-diabetic TG mice.The DPP4 inhibitor ameliorated cardiac function by inhibiting the inactivation of HMGB1 in diabetic mice after MI.	Thioguanine	82-84	dipeptidylpeptidase 4	Mus musculus	205-209
28966507-1	2017	BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine.	Thioguanine	158-171	thiopurine S-methyltransferase	Homo sapiens	44-48
28212467-0	2017	Comparison of 6-mercaptopurine with 6-thioguanine for the analysis of thiopurine S-methyltransferase activity in human erythrocyte by LC-MS/MS.	Thioguanine	36-49	thiopurine S-methyltransferase	Homo sapiens	70-100
29152131-6	2017	In addition, miR-130b-DEX did not change cell proliferation but significantly decreased TG concentration and PPAR-gamma expression compared to miR-SC-DEX cells, while miR-130b-inhibitor-DEX cells presented opposite results.	Thioguanine	88-90	microRNA 130b	Homo sapiens	13-21
29152131-6	2017	In addition, miR-130b-DEX did not change cell proliferation but significantly decreased TG concentration and PPAR-gamma expression compared to miR-SC-DEX cells, while miR-130b-inhibitor-DEX cells presented opposite results.	Thioguanine	88-90	membrane associated ring-CH-type finger 8	Homo sapiens	13-16
28739396-10	2017	TNF-alpha -308 (G/A), and TNF-beta +252 (A/G) haplotype "GG" "AG" increased CAD risk significantly (GG haplotype, adjusted OR=2.6, CI 1.4-5.0, p=0.003 and AG haplotype OR=8.5, CI 2.2-33.35, p=0.002) after adjustments for age, sex, TC, TG, HDL, APOB, smoking and diet.	Thioguanine	235-237	lymphotoxin alpha	Homo sapiens	26-34
29082080-3	2017	Here we study the development of the pupal eye in Drosophila melanogaster and determine the localization of rhodopsin using THG microscopy technique.	Thioguanine	124-127	neither inactivation nor afterpotential E	Drosophila melanogaster	108-117
29082080-4	2017	Additionally, by altering the chromophore or the opsin protein we were able to detect changes in both the retinal distribution morphology and in THG intensity age-dependent profiles.	Thioguanine	145-148	neither inactivation nor afterpotential E	Drosophila melanogaster	49-54
28212467-5	2017	A computer-based simulation indicated that 6-MP and 6-TG had similar affinities for the two active sites of TPMT.	Thioguanine	52-56	thiopurine S-methyltransferase	Homo sapiens	108-112
28212467-6	2017	According to the guidelines, an LC-MS/MS method was developed and validated to evaluate the TPMT activity in human erythrocyte hemolysate using 6-MP or 6-TG as substrates via 1 h incubation at 37 C. The method was applied in 81 patients with NMOSD.	Thioguanine	152-156	thiopurine S-methyltransferase	Homo sapiens	92-96
28476574-11	2017	Particularly, the CC genotype of PPARgamma rs2920502 was statistically correlated with the enhanced serum TG level, p=0.011.These results suggest that the variants of PPARgamma, RUNX2, COL2A1, and IGFBP3 genes closely associated with the development of ONFH.	Thioguanine	106-108	peroxisome proliferator activated receptor gamma	Homo sapiens	33-42
28782559-7	2017	As proof of principle, we conducted two independent screenings for resistance against 6-thioguanine and an ATR inhibitor, which identified mutations known to provide resistance to these reagents and revealed ECT2 as a novel determinant for the sensitivity to ATR inhibition.	Thioguanine	86-99	epithelial cell transforming 2	Homo sapiens	208-212
28782559-7	2017	As proof of principle, we conducted two independent screenings for resistance against 6-thioguanine and an ATR inhibitor, which identified mutations known to provide resistance to these reagents and revealed ECT2 as a novel determinant for the sensitivity to ATR inhibition.	Thioguanine	86-99	ATR serine/threonine kinase	Homo sapiens	259-262
28842599-7	2017	We found that miR-210 levels were rapidly increased in TG-210 mice upon doxycycline administration.	Thioguanine	55-57	microRNA 210	Mus musculus	14-21
27753229-3	2017	Quantification of THG signal can accurately distinguish HER2-positive cells.	Thioguanine	18-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-60
28870033-8	2017	(3) The serum PCSK9 levels were positively correlated with RF, TC, TG, LDL, very low density lipoprotein (VLDL), ApoB, with r values as 0.303, 0.490, 0.320, 0.451, 0.319, 0.463, respectively (P&lt;0.05).	Thioguanine	67-69	proprotein convertase subtilisin/kexin type 9	Homo sapiens	14-19
28870033-10	2017	Conclusions: The serum PCSK9 level is elevated in RA patients, which is related to RF, disease activity, TC, TG, LDL, VLDL, ApoB.	Thioguanine	109-111	proprotein convertase subtilisin/kexin type 9	Homo sapiens	23-28
28712454-6	2017	We functionally assayed programmed deletions in parallel by selecting for loss of HPRT function with 6-thioguanine.	Thioguanine	101-114	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	82-86
28476574-11	2017	Particularly, the CC genotype of PPARgamma rs2920502 was statistically correlated with the enhanced serum TG level, p=0.011.These results suggest that the variants of PPARgamma, RUNX2, COL2A1, and IGFBP3 genes closely associated with the development of ONFH.	Thioguanine	106-108	peroxisome proliferator activated receptor gamma	Homo sapiens	167-176
28476574-11	2017	Particularly, the CC genotype of PPARgamma rs2920502 was statistically correlated with the enhanced serum TG level, p=0.011.These results suggest that the variants of PPARgamma, RUNX2, COL2A1, and IGFBP3 genes closely associated with the development of ONFH.	Thioguanine	106-108	RUNX family transcription factor 2	Homo sapiens	178-183
28476574-11	2017	Particularly, the CC genotype of PPARgamma rs2920502 was statistically correlated with the enhanced serum TG level, p=0.011.These results suggest that the variants of PPARgamma, RUNX2, COL2A1, and IGFBP3 genes closely associated with the development of ONFH.	Thioguanine	106-108	collagen type II alpha 1 chain	Homo sapiens	185-191
28668302-9	2017	In APOE-/- mice fed a high-fat diet (HFD) for 16weeks, serum lipid profiles (FFAs, TG, TC) and blood glucose levels were significantly increased compared with mice fed a normal diet.	Thioguanine	83-85	apolipoprotein E	Mus musculus	3-7
27041637-6	2017	Interaction of Fas and FasL was involved in the cytotoxicity of NKT cells against hepatocytes in the HBs-Tg mice.	Thioguanine	105-107	Fas ligand (TNF superfamily, member 6)	Mus musculus	23-27
28810592-6	2017	At 3 days after operation, echocardiographic posterior wall thickness at end diastole (PWTD) and end systolic PWTS of Tg-ERbeta mice were significantly reduced, and left ventricular systolic diameter and left ventricular diastolic diameter significantly increased (P&lt;0.05) compared with NLC mice.	Thioguanine	118-120	estrogen receptor 2 (beta)	Mus musculus	121-127
28810592-8	2017	In conclusion, Tg-ERbeta exerts a protective effect on MI.	Thioguanine	15-17	estrogen receptor 2 (beta)	Mus musculus	18-24
28406575-7	2017	Correspondingly TG was severely reduced at baseline and improved at recovery (peak thrombin 6.0 to 54 nm).	Thioguanine	16-18	coagulation factor II, thrombin	Homo sapiens	83-91
28498075-0	2017	The impact of 6-thioguanine incorporation into DNA on the function of DNA methyltransferase Dnmt3a.	Thioguanine	14-27	DNA methyltransferase 3 alpha	Homo sapiens	92-98
28488385-5	2017	On a C3H/HeJ background, zinc-induced Tg-R266K Cbs-/- mice express CBS mRNA, but have very low levels of CBS protein and enzyme activity, resulting in extreme elevations in serum total homocysteine (tHcy).	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	47-50
28488385-5	2017	On a C3H/HeJ background, zinc-induced Tg-R266K Cbs-/- mice express CBS mRNA, but have very low levels of CBS protein and enzyme activity, resulting in extreme elevations in serum total homocysteine (tHcy).	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	67-70
28465231-2	2017	The aim of this study was to define the role of Rac-1 in the formation of platelet-derived microparticles (PMPs) and thrombin generation (TG) in abdominal sepsis.	Thioguanine	138-140	coagulation factor II	Mus musculus	117-125
27271124-7	2017	Indeed, we demonstrate that apoD can attenuate intracellular cholesterol content in primary hippocampal neurons and in brain of H-apoD Tg mice.	Thioguanine	135-137	apolipoprotein D	Mus musculus	28-32
27271124-7	2017	Indeed, we demonstrate that apoD can attenuate intracellular cholesterol content in primary hippocampal neurons and in brain of H-apoD Tg mice.	Thioguanine	135-137	apolipoprotein D	Mus musculus	130-134
28750017-10	2017	Collectively our data suggest that the beneficial effects of CRFR1 antagonism seen in Tg mice may be mechanistically linked to the modulation of oxidative stress pathways.	Thioguanine	86-88	corticotropin releasing hormone receptor 1	Mus musculus	61-66
28761205-11	2017	RESULTS: The expression of HSP70 was significantly higher in the keratinocytes of the TG (20.25+-3.53; P&lt;0.001) than in the keratinocytes of the CG (10.50+-2.44; P&lt;0.001).	Thioguanine	86-88	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	27-32
27756600-9	2017	Assessment of myocardial infarct size in response to 60min of ischemia and 24h of reperfusion demonstrated a significant reduction in infarct size in alphaMHC/hCD39-Tg hearts.	Thioguanine	165-167	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	159-164
28092402-8	2017	The administration of exogenous IL-23 enhanced IL-17A production from Vgamma4 gammadelta T cells and ameliorated liver damage in HBs-Tg mice, but not in HBs-Tg-TCR-delta-/- mice.	Thioguanine	133-135	interleukin 23, alpha subunit p19	Mus musculus	32-37
28472132-8	2017	Nevertheless, in silico analysis shows that normalization of either prothrombin conversion or thrombin inactivation to physiological levels, by for example the administration of prothrombin complex concentrates would cause an elevation of TG, whereas the normalization of both simultaneously maintains a balanced TG.	Thioguanine	239-241	coagulation factor II, thrombin	Homo sapiens	71-79
28472132-8	2017	Nevertheless, in silico analysis shows that normalization of either prothrombin conversion or thrombin inactivation to physiological levels, by for example the administration of prothrombin complex concentrates would cause an elevation of TG, whereas the normalization of both simultaneously maintains a balanced TG.	Thioguanine	313-315	coagulation factor II, thrombin	Homo sapiens	71-79
28243972-8	2017	Notably, in vitro study showed that R128* mutation severely damaged the TG-biosynthesis ability of DGAT2, and all other R128* carriers in the pedigree were lean.	Thioguanine	72-74	diacylglycerol O-acyltransferase 2	Homo sapiens	99-104
28536535-11	2017	Despite the sexually dimorphic effect on acute intestinal lipid handling, Tg(fabp2a:EGFP-nr1h3) adults of both sexes are protected from high cholesterol diet (HCD)-induced hepatic lipid accumulation, while nr1h3-/- mutants are sensitive to the effects of HCD challenge.	Thioguanine	74-76	nuclear receptor subfamily 1, group H, member 3	Danio rerio	89-94
28536535-11	2017	Despite the sexually dimorphic effect on acute intestinal lipid handling, Tg(fabp2a:EGFP-nr1h3) adults of both sexes are protected from high cholesterol diet (HCD)-induced hepatic lipid accumulation, while nr1h3-/- mutants are sensitive to the effects of HCD challenge.	Thioguanine	74-76	nuclear receptor subfamily 1, group H, member 3	Danio rerio	206-211
28205396-6	2017	RESULTS: Thrombin peak height (TPH) was strongly CaCl2 dependent, increasing sharply from no TG at 5 mm to a peak at 13.8 mm of CaCl2 (95% confidence interval [CI]: 13.0, 14.5) in normal and normalized deficient plasmas and at 11.9 mm (CI: 9.7, 14.2) in deficient plasmas, and then decreasing slowly to a complete inhibition at 30-40 mm.	Thioguanine	93-95	coagulation factor II, thrombin	Homo sapiens	9-17
28438863-6	2017	RESULTS: p16 540C G genotype distribution was found to be: CC: 66.2%, CG: 28.4%, GG: 5.4%; p16 580C T genotype distribution was found to be: CC: 82.4%, CT: 17.6%, TT: 0% and MDM2 genotype distribution was found to be: TT: 31.1%, TG: 47.3%, GG: 21.6% in patients with prolactinoma.	Thioguanine	229-231	cyclin dependent kinase inhibitor 2A	Homo sapiens	9-12
28438863-6	2017	RESULTS: p16 540C G genotype distribution was found to be: CC: 66.2%, CG: 28.4%, GG: 5.4%; p16 580C T genotype distribution was found to be: CC: 82.4%, CT: 17.6%, TT: 0% and MDM2 genotype distribution was found to be: TT: 31.1%, TG: 47.3%, GG: 21.6% in patients with prolactinoma.	Thioguanine	229-231	cyclin dependent kinase inhibitor 2A	Homo sapiens	91-94
28019133-8	2017	A relationship was detected between H score, FSH, LH, total testosterone, HDL-C and TG levels and CG + GG genotypes of IL-6.	Thioguanine	84-86	interleukin 6	Homo sapiens	119-123
27895157-7	2017	Additionally, the cisplatin-induced enhancement of p53 activation, NF-kappaB binding to DNA, and NF-kappaB nuclear translocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX-/- mice.	Thioguanine	164-166	transformation related protein 53, pseudogene	Mus musculus	51-54
27895157-7	2017	Additionally, the cisplatin-induced enhancement of p53 activation, NF-kappaB binding to DNA, and NF-kappaB nuclear translocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX-/- mice.	Thioguanine	164-166	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
27895157-7	2017	Additionally, the cisplatin-induced enhancement of p53 activation, NF-kappaB binding to DNA, and NF-kappaB nuclear translocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX-/- mice.	Thioguanine	164-166	myo-inositol oxygenase	Mus musculus	159-163
27595975-10	2017	The equation of: LDLc (mg/dl) = 0.75 TC - 0.5 HDLc - 0.1 TG had the lowest mean and SD of difference among all the methods examined here.	Thioguanine	57-59	component of oligomeric golgi complex 2	Homo sapiens	17-21
27595975-13	2017	CONCLUSIONS: Our data suggest the simplest formula: LDLc = 0.545 TC or a more detailed: LDLc = 0.75 TC - 0.5 HDLc - 0.1 TG be used for calculating serum LDLc.	Thioguanine	120-122	component of oligomeric golgi complex 2	Homo sapiens	52-56
27595975-13	2017	CONCLUSIONS: Our data suggest the simplest formula: LDLc = 0.545 TC or a more detailed: LDLc = 0.75 TC - 0.5 HDLc - 0.1 TG be used for calculating serum LDLc.	Thioguanine	120-122	component of oligomeric golgi complex 2	Homo sapiens	88-92
27595975-13	2017	CONCLUSIONS: Our data suggest the simplest formula: LDLc = 0.545 TC or a more detailed: LDLc = 0.75 TC - 0.5 HDLc - 0.1 TG be used for calculating serum LDLc.	Thioguanine	120-122	component of oligomeric golgi complex 2	Homo sapiens	88-92
28207959-3	2017	As exercise increases the efficiency of very low-density lipoprotein-triglyceride (VLDL-TG) oxidation, we hypothesized that muscle LPL activity would be a rate-limiting step and predict VLDL-TG Fatty acids oxidation during exercise.	Thioguanine	88-90	lipoprotein lipase	Homo sapiens	131-134
28434010-9	2017	Correlational analysis of the nutritional indicators showed that the correlations between Hb, ALB, TG, TC, Ur, and BUN with an eGFR lower than 60 mL/min/1.73 m2 were 0.582, 0.780, 1.219, 1.364, 2.180, and 3.677, respectively.	Thioguanine	99-101	epidermal growth factor receptor	Homo sapiens	127-131
28259175-9	2017	The levels of TNF-alpha, IL-6, and MCP-1 in response to LPS were significantly increased in the PFC of PTN-Tg mice compared to that of WT mice.	Thioguanine	107-109	mast cell protease 1	Mus musculus	35-40
28258168-7	2017	Neurotoxins that mimic Parkinson"s disease increased Cav1.3 function, decreased TRPC1 expression, inhibited Tg-mediated STIM1-Cav1.3 interaction, and induced caspase activation.	Thioguanine	108-110	stromal interaction molecule 1	Homo sapiens	120-125
28258168-7	2017	Neurotoxins that mimic Parkinson"s disease increased Cav1.3 function, decreased TRPC1 expression, inhibited Tg-mediated STIM1-Cav1.3 interaction, and induced caspase activation.	Thioguanine	108-110	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	126-132
28259175-9	2017	The levels of TNF-alpha, IL-6, and MCP-1 in response to LPS were significantly increased in the PFC of PTN-Tg mice compared to that of WT mice.	Thioguanine	107-109	tumor necrosis factor	Mus musculus	14-23
28259175-9	2017	The levels of TNF-alpha, IL-6, and MCP-1 in response to LPS were significantly increased in the PFC of PTN-Tg mice compared to that of WT mice.	Thioguanine	107-109	interleukin 6	Mus musculus	25-29
28153384-1	2017	A wide range of studies both in humans and animal models point GALNT2 as a shaper of serum HDL-C and TG levels.	Thioguanine	101-103	polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	63-69
28153384-2	2017	Available data in humans indicate that, while under conditions of extreme GALNT2 loss-of-function HDL-C is the main target, a fine-tuning of GALNT2 changes is mostly associated with TG levels.	Thioguanine	182-184	polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	141-147
28153384-3	2017	Understanding whether different degrees of GALNT2 change do modulate different serum lipid fractions and, if so, addressing the mechanisms underlying such pleiotropic effects has the potential not only to improve our understanding of HDL-C and TG metabolism, but also to make GALNT2 becoming a target for treating atherogenic dyslipidemia and related clinical events.	Thioguanine	244-246	polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	43-49
28361971-3	2017	A total of 61 patients with acute spontaneous ICH were randomized to either the treatment group (TG, 30 patients), which received 3 doses of PG2 (500 mg, IV) per week for 2 weeks, or the control group (CG, 31 patients), which received PG2 placebo.	Thioguanine	97-99	delta like non-canonical Notch ligand 1	Homo sapiens	141-144
28264047-12	2017	Finally, ANGPTL7 circulating level showed significant association with TG level in the obese subjects (R2 = 0.183, p-Value = 0.03).	Thioguanine	71-73	angiopoietin like 7	Homo sapiens	9-16
28264047-14	2017	Increased expression of ANGPTL7 might play a minor role in the regulation of TG level in obese subjects either directly or through interaction with other ANGPTL protein members.	Thioguanine	77-79	angiopoietin like 7	Homo sapiens	24-31
28259175-9	2017	The levels of TNF-alpha, IL-6, and MCP-1 in response to LPS were significantly increased in the PFC of PTN-Tg mice compared to that of WT mice.	Thioguanine	107-109	pleiotrophin	Mus musculus	103-106
26582580-9	2017	CONCLUSIONS: STAT5 MKO in conjunction with a HFD deregulated both lipid and glucose metabolism in skeletal muscle, and this deregulation induced hepatic fat accumulation via increased circulating glucose, FFA, and TG concentrations.	Thioguanine	214-216	signal transducer and activator of transcription 5A	Mus musculus	13-18
27898284-9	2017	However, LPL activity correlated with fractional VLDL-TG storage in abdominal fat (P = 0.04).	Thioguanine	54-56	lipoprotein lipase	Homo sapiens	9-12
30160407-11	2017	A little SC2 contained into TBzDT was revealed by FTIR, TG-DTA from different sides.	Thioguanine	56-58	trans-2,3-enoyl-CoA reductase	Homo sapiens	9-12
28134375-4	2017	The red-NIR fluorescence probe TG-SA can be effectively used for staining HSA/SA in gel electrophoresis, quantification and validation of HSA in clinical urine samples and monitoring serum albumin in live cells.	Thioguanine	31-33	albumin	Homo sapiens	183-196
28219140-26	2017	(6) On culture day 2, 4, and 7, mRNA expressions of TIMP-3 of cells in groups THG and PHG were similar (with P values above 0.05), which were significantly lower than those in group C (with P values below 0.05).	Thioguanine	78-81	TIMP metallopeptidase inhibitor 3	Homo sapiens	52-58
27862177-7	2017	Interestingly, the percentage of NKG2D+ NK cells negatively correlated with the level of serum TCHOL and TG in T1DM patients.	Thioguanine	105-107	killer cell lectin like receptor K1	Homo sapiens	33-38
27982425-0	2017	Ublituximab (TG-1101), a novel glycoengineered anti-CD20 antibody, in combination with ibrutinib is safe and highly active in patients with relapsed and/or refractory chronic lymphocytic leukaemia: results of a phase 2 trial.	Thioguanine	13-15	keratin 20	Homo sapiens	52-56
27976586-8	2017	Spectroscopy measurements indicate that the photo-orientation of DR1 and its thermal stability are maximal with Tg around 70  C, independent of the azo content.	Thioguanine	112-114	down-regulator of transcription 1	Homo sapiens	65-68
28052000-2	2017	ASP binding to C5L2 leading to a net accumulation of TG stores and glucose transporter.	Thioguanine	53-55	complement C5a receptor 2	Homo sapiens	15-19
28072841-8	2017	Increased production of adiponectin in db/db mice due to dmp effected lowering of circulatory TG and FFA levels, activates AMPK in skeletal muscle and this stimulates mitochondrial biogenesis and bioenergetics.	Thioguanine	94-96	adiponectin, C1Q and collagen domain containing	Mus musculus	24-35
28072841-8	2017	Increased production of adiponectin in db/db mice due to dmp effected lowering of circulatory TG and FFA levels, activates AMPK in skeletal muscle and this stimulates mitochondrial biogenesis and bioenergetics.	Thioguanine	94-96	dentin matrix protein 1	Mus musculus	57-60
28059134-1	2017	The purpose of this study was to investigate the usefulness of triglyceride to hdl-c ratio (TG:HDL-C) as an insulin resistance (IR) marker for overweight and obese children.	Thioguanine	92-94	insulin	Homo sapiens	108-115
28263540-4	2016	Estrogen Receptor Transactivation in vitro Assay to Detect Estrogen Receptor Agonists and Antagonists (OECD TG 455/457) using the VM7Luc4E2 (formerly designated BG1Luc4E2) cell line was performed for measurement of transactivation activity of the tested substances.	Thioguanine	108-110	estrogen receptor 1	Homo sapiens	0-17
27411368-9	2017	Remarkably, colitis improved without immunosuppressive effects in the absence of host hypoxanthine (guanine) phosphoribosyltransferase (Hprt)-mediated conversion of TG to active drug, the thioguanine nucleotides (TGN).	Thioguanine	165-167	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	136-140
27774726-6	2017	The Fiix-PT is only affected by FII and FX, the main contributors to thrombin generation (TG).	Thioguanine	90-92	coagulation factor II, thrombin	Homo sapiens	69-77
28008992-7	2016	In primary rat hepatocytes, the incubation with both acylated and desacyl ghrelin (10, 100 and 1,000 pmol/L) significantly increased TG content, triggered AMPK-activated mitochondrial FFA beta-oxidation and autophagy.	Thioguanine	133-135	ghrelin and obestatin prepropeptide	Rattus norvegicus	74-81
28578349-9	2017	In PTPRO-over-expressing cells, CD36 expression and the level of oil-red staining, TC and TG were increased; ROS production, MDA and level of cell apoptosis were improved, but SOD was reduced.	Thioguanine	90-92	protein tyrosine phosphatase, receptor type, O	Mus musculus	3-8
27723573-6	2016	Besides that, certain marker proteins of ER stress (e.g. GRP78, CHOP, and cytochrome c) and calcium concentrations in neurons were significantly increased when TG was applied, while these levels were reduced to normal conditions when GTM-1 was added in the treatment.	Thioguanine	160-162	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	57-62
27973513-2	2016	Utilizing this special property, we designed a THG converter based on one KDP crystal.	Thioguanine	47-50	WNK lysine deficient protein kinase 1	Homo sapiens	74-77
27723573-6	2016	Besides that, certain marker proteins of ER stress (e.g. GRP78, CHOP, and cytochrome c) and calcium concentrations in neurons were significantly increased when TG was applied, while these levels were reduced to normal conditions when GTM-1 was added in the treatment.	Thioguanine	160-162	DNA-damage inducible transcript 3	Rattus norvegicus	64-68
27707816-6	2016	In rhesus monkeys, over 90% SCAP mRNA KD was achieved resulting in approximately 75, 50, and 50% reduction of plasma PCSK9, TG, and LDL-C, respectively.	Thioguanine	124-126	SREBF chaperone	Macaca mulatta	28-32
26696493-6	2016	Interestingly, the NMDA receptor antagonist memantine restored behavioral abnormalities in TERT-tg mice.	Thioguanine	96-98	telomerase reverse transcriptase	Mus musculus	91-95
27777315-6	2016	Eight methylation sites encompassing five genes, LPP, CPT1A, APOA5, SREBF1, and ABCG1, were significantly associated with PPL response at an epigenome-wide level (P &lt; 1.1 x 10-7), but no methylation site reached epigenome-wide significance after adjusting for baseline TG levels.	Thioguanine	272-274	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	49-52
27777315-7	2016	Higher methylation at LPP, APOA5, SREBF1, and ABCG1, and lower methylation at CPT1A methylation were correlated with an increased TG-PPL response.	Thioguanine	130-132	carnitine palmitoyltransferase 1A	Homo sapiens	78-83
27614854-1	2016	The goal of this analysis was to evaluate the ability of insulin resistance, identified by the presence of prediabetes mellitus (PreDM) combined with either an elevated triglyceride (TG &gt;1.7 mmol/l) or body mass index (BMI &gt;=27.0 kg/m2), to identify increased risk of statin-associated type 2 diabetes mellitus (T2DM).	Thioguanine	183-185	insulin	Homo sapiens	57-64
31435207-6	2017	Alanine aminotransferase (ALT) was significantly and positively correlated with FasL, TG, glucose levels and body mass index (BMI) in diabetic patients.	Thioguanine	86-88	glutamic--pyruvic transaminase	Homo sapiens	0-24
27740931-1	2016	BACKGROUND: Studies have suggested the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) as a surrogate marker of insulin resistance.	Thioguanine	99-101	insulin	Homo sapiens	134-141
27814764-9	2016	The path coefficients from baseline TG and HDL-C to follow-up 2-h insulin were significantly greater than those from baseline 2-h insulin to follow-up TG and HDL-C (beta1 = 0.125 vs beta2 = 0.040, P &lt; 0.001 for TG; beta1 = -0.112 vs beta2 = -0.026, P &lt; 0.001 for HDL-C).	Thioguanine	36-38	insulin	Homo sapiens	66-73
27814764-10	2016	2-h insulin partially mediated the effect of TG/HDL-C on Gutt index with a 59.3% mediating effect for TG and 61.0% for HDL-C.	Thioguanine	45-47	insulin	Homo sapiens	4-11
27814764-10	2016	2-h insulin partially mediated the effect of TG/HDL-C on Gutt index with a 59.3% mediating effect for TG and 61.0% for HDL-C.	Thioguanine	102-104	insulin	Homo sapiens	4-11
27207494-12	2016	Heterozygous (TG) and mutants (GG) forms of Apa1 VDR SNPs were significantly associated with TBM compared to controls [TG; p = 0.001, OR = 2.86 (1.58-5.17), GG; p = 0.002, OR = 5.11 (1.80-14.54)] and pulmonary tuberculosis.	Thioguanine	14-16	vitamin D receptor	Homo sapiens	49-52
27785069-5	2016	Overall, compared with the control group, a significantly increased SCC risk was observed for the MDM2 rs2279744 polymorphism in the Asian population (test of association: odds ratio [OR] 1.12, P=0.027 for G vs T; OR 1.26, P=0.016 for GG vs TT; OR 1.25, P&lt;0.001 for GG vs TT + TG; and OR 1.08, P=0.023 for carrier G vs T).	Thioguanine	280-282	serpin family B member 3	Homo sapiens	68-71
27785069-5	2016	Overall, compared with the control group, a significantly increased SCC risk was observed for the MDM2 rs2279744 polymorphism in the Asian population (test of association: odds ratio [OR] 1.12, P=0.027 for G vs T; OR 1.26, P=0.016 for GG vs TT; OR 1.25, P&lt;0.001 for GG vs TT + TG; and OR 1.08, P=0.023 for carrier G vs T).	Thioguanine	280-282	MDM2 proto-oncogene	Homo sapiens	98-102
27785069-6	2016	In subgroup analysis by SCC type, a similarly increased esophageal SCC risk was detected (OR 1.19, P&lt;0.001 for G vs T; OR 1.46, P&lt;0.001 for GG vs TT; and OR 1.48, P=0.005 for GG vs TT + TG).	Thioguanine	192-194	serpin family B member 3	Homo sapiens	67-70
27932105-12	2016	Biopsy specimens with transplant glomerulopathy (TG) showed lower levels of circulating naive CD19 + subpopulation, IgD+, and CD27- (32.7 +- 28.1 vs 87.9 +- 79.1; P = .017) compared with biopsy specimens without TG.	Thioguanine	49-51	CD19 molecule	Homo sapiens	94-98
27932105-12	2016	Biopsy specimens with transplant glomerulopathy (TG) showed lower levels of circulating naive CD19 + subpopulation, IgD+, and CD27- (32.7 +- 28.1 vs 87.9 +- 79.1; P = .017) compared with biopsy specimens without TG.	Thioguanine	49-51	CD27 molecule	Homo sapiens	126-130
27530327-0	2016	NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.	Thioguanine	72-85	nudix hydrolase 15	Homo sapiens	0-6
27372042-4	2016	In this study, the effect of cholesterol and TG of plasma of patients with PAD on NLRP1 inflammasome gene expression in human arterial endothelial cells (HAECS) was assessed.	Thioguanine	45-47	NLR family pyrin domain containing 1	Homo sapiens	82-87
27372042-11	2016	CONCLUSIONS: Plasma TG and VLDL cholesterol of patients with atherosclerosis, manifested as PAD, promote the in vitro NLRP1 inflammasome expression in HAECs.	Thioguanine	20-22	NLR family pyrin domain containing 1	Homo sapiens	118-123
27818935-5	2016	RESULTS: Plasma cholesterol, hepatic lipid, and cholesterol crystal formation in the gallbladder were lower in CREBH Tg mice fed a lithogenic diet (LD) than in LD-fed WTs, while fecal cholesterol output was higher in the former.	Thioguanine	117-119	cAMP responsive element binding protein 3-like 3	Mus musculus	111-116
27557897-6	2016	Moreover, the mutant homozygous and heterozygous eNOS genotype together were significantly associated with higher TC, LDLc, (P &lt; 0.001), and TG (P = 0.001).	Thioguanine	144-146	nitric oxide synthase 3	Homo sapiens	49-53
27530327-7	2016	Mechanistic investigations in cells indicated that NUDT15 ablation potentiated induction of the DNA damage checkpoint and cancer cell death by 6-thioguanine.	Thioguanine	143-156	nudix hydrolase 15	Homo sapiens	51-57
27579478-2	2016	The as-prepared VP-PIL features low Tg (47  C), good thermal stability (Td   284  C) and solubility in ranges of polar solvents.	Thioguanine	36-38	serpin family A member 2 (gene/pseudogene)	Homo sapiens	19-22
27569393-8	2016	Co-exposure to Sal B (0.2-2 mumol/L) dose-dependently increased the bone mineralization area and IOD in AB zebafish larvae and osteoblast fluorescence in tg (sp7:egfp) zebrafish larvae.	Thioguanine	154-156	Sp7 transcription factor	Danio rerio	158-161
27417582-10	2016	FeCl3-induced arterial thrombosis in chimeric mice revealed a significant prolongation in the time to thrombosis in hCD39-Tg reconstituted wild-type mice, but not on wild-type reconstituted hCD39-Tg mice.	Thioguanine	122-124	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	116-121
27417582-11	2016	Monocyte depletion with clodronate-loaded liposomes normalized the time to thrombosis in hCD39-Tg mice compared with hCD39-Tg mice treated with control liposomes, demonstrating that increased CD39 expression on monocytes protects against thrombosis.	Thioguanine	95-97	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	89-94
27417582-11	2016	Monocyte depletion with clodronate-loaded liposomes normalized the time to thrombosis in hCD39-Tg mice compared with hCD39-Tg mice treated with control liposomes, demonstrating that increased CD39 expression on monocytes protects against thrombosis.	Thioguanine	95-97	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	90-94
27530451-7	2016	Notably, additional Tg(PPAR-gamma) or pharmacological activation of PPAR-gamma effectively prevented Tg(DNMT1)-induced proinflammatory cytokine production in macrophages and AS development in the mouse model.	Thioguanine	20-22	peroxisome proliferator activated receptor gamma	Mus musculus	23-33
27471037-1	2016	BACKGROUND: The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings.	Thioguanine	49-51	insulin	Homo sapiens	102-109
27687656-6	2016	Serum omentin-1 level was positively correlated with HDL but inversely with BMI (at pregnancy and before delivery), FPG, FINS and HOMA-IR; Chemerin was positively correlated with TC, TG, hs-CRP and FPG; serum omentin-1 and chemerin levels were not significant correlated (P=0.301).	Thioguanine	183-185	retinoic acid receptor responder 2	Homo sapiens	139-147
27530451-7	2016	Notably, additional Tg(PPAR-gamma) or pharmacological activation of PPAR-gamma effectively prevented Tg(DNMT1)-induced proinflammatory cytokine production in macrophages and AS development in the mouse model.	Thioguanine	20-22	DNA methyltransferase (cytosine-5) 1	Mus musculus	104-109
27354419-6	2016	Deletion of liver SHP prevented increases in TG production and expression of genes involved in VLDL synthesis in CETP mice with estrogen treatment.	Thioguanine	45-47	nuclear receptor subfamily 0, group B, member 2	Mus musculus	18-21
27497473-9	2016	Further stratification study showed that high serum levels of CETP was an independent risk factor of MCI in diabetic patients with a low density lipoproteins level &gt;=2.59 mmol/L, or high density lipoproteins level &lt;=1.0 mmol/L for men and &lt;=1.3 mmol/L for women, or TG level &gt;=1.7 mmol/L, after adjusting for age, sex, education, and glucose control (all ps &lt; 0.05).	Thioguanine	275-277	cholesteryl ester transfer protein	Homo sapiens	62-66
27354419-10	2016	Thus, CETP alters at least two networks governing TG metabolism, one involving SHP to increase VLDL-TG production in response to estrogen, and another involving ERalpha to enhance beta-oxidation and lower liver TG content.	Thioguanine	50-52	nuclear receptor subfamily 0, group B, member 2	Mus musculus	79-82
27354419-10	2016	Thus, CETP alters at least two networks governing TG metabolism, one involving SHP to increase VLDL-TG production in response to estrogen, and another involving ERalpha to enhance beta-oxidation and lower liver TG content.	Thioguanine	100-102	nuclear receptor subfamily 0, group B, member 2	Mus musculus	79-82
27143021-6	2016	RESULTS: 41/75 tumors were pT3 (23 cases [53.4 %] in the PG and 18 cases [56.3 %] in the TG group).	Thioguanine	89-91	zinc finger protein 135	Homo sapiens	27-30
27166132-2	2016	AIM: This study carried out in patients with unmeasurable FVIII (&lt;1 IU dL(-1) ) was aimed at unravelling any difference in TG capacity in patients with or without inhibitors.	Thioguanine	126-128	coagulation factor VIII	Homo sapiens	58-63
26879158-4	2016	RESULTS: Increasing the FXa/FII ratio improved TG, while adding coagulation enzyme components had a negligible effect.	Thioguanine	47-49	coagulation factor X	Homo sapiens	24-27
27281478-7	2016	VNN1-treated mice showed increased liver lipid content and plasma levels of TG (124.48%), LDL-cholesterol (119.64%), TNF-alpha (148.74%), interleukin (IL)-1beta (131.81%), and IL-6 (156.51%), whereas plasma levels of HDL-C (25.75%) were decreased significantly (P &lt; 0.05).	Thioguanine	76-78	vanin 1	Mus musculus	0-4
27126697-5	2016	In 10-month-old TG, cardiomyocyte elongation and hypertrophic remodeling and increased glycolytic flux was accompanied by relatively low expression of FAT/CD36, CPT-1 and PPARalpha.	Thioguanine	16-18	peroxisome proliferator activated receptor alpha	Mus musculus	171-180
27126697-6	2016	During the transition phase (12-month-old TG), a pronounced increase in PPARalpha with an increase in relative fatty acid (FA) flux was associated with anomalies of cardiomyocytes with accumulation of lipid droplets and glycogen as well as cell death.	Thioguanine	42-44	peroxisome proliferator activated receptor alpha	Mus musculus	72-81
27405296-1	2016	BACKGROUND: LDL-C, non-HDL-C and ApoB levels are inter-correlated and all predict risk of atherosclerotic cardiovascular disease (ASCVD) in patients with type 2 diabetes mellitus (T2DM) and/or high TG.	Thioguanine	198-200	apolipoprotein B	Homo sapiens	33-37
26919654-11	2016	ABBREVIATIONS: ACTN3 = alpha-actinin-3 BMI = body mass index CVD = cardiovascular disease HDL-C = high-density lipoprotein cholesterol LDL-C = low-density lipoprotein cholesterol R = arginine (R) at amino acid position 577 of the ACTN3 protein TC = total cholesterol TG = triglyceride X = truncation at amino acid position 577 of the ACTN3 protein.	Thioguanine	267-269	actinin alpha 3	Homo sapiens	15-20
27197961-3	2016	AIM: The aims of this study, carried out in patients candidate to orthopaedic surgery, were to assess the dose-dependent increase in thrombin generation (TG) after infusion of bypassing agents and to evaluate whether or not a correlation existed between the haemostatic efficacy of bypassing therapies and perioperative TG values.	Thioguanine	154-156	coagulation factor II, thrombin	Homo sapiens	133-141
27382199-8	2016	Logistic regression analysis showed the negative association of LPL S447X variant with TG and VLDL cholesterol, while no association with total cholesterol, HDL cholesterol and LDL cholesterol was found.	Thioguanine	87-89	lipoprotein lipase	Homo sapiens	64-67
27330794-5	2016	The overall analysis revealed a significant association between MDM2 SNP309 and OSCC risk in the heterozygote (TG vs. TT: OR=0.81; 95% CI: 0.68-0.96; P=0.02) and dominant models (TG+GG vs. TT: OR=0.82; 95% CI: 0.69-0.97; P=0.02).	Thioguanine	111-113	transformed mouse 3T3 cell double minute 2	Mus musculus	64-68
27234787-1	2016	LPL is a pivotal rate-limiting enzyme to catalyze the hydrolysis of TG in circulation, and plays a critical role in regulating lipid metabolism.	Thioguanine	68-70	lipoprotein lipase	Mus musculus	0-3
27330794-5	2016	The overall analysis revealed a significant association between MDM2 SNP309 and OSCC risk in the heterozygote (TG vs. TT: OR=0.81; 95% CI: 0.68-0.96; P=0.02) and dominant models (TG+GG vs. TT: OR=0.82; 95% CI: 0.69-0.97; P=0.02).	Thioguanine	179-181	transformed mouse 3T3 cell double minute 2	Mus musculus	64-68
27313062-4	2016	However, unexpectedly, only two BRCA1-mutant cell lines, HCC1937 and MDA-MB-436, were hypersensitive to a nucleotide analogue 6-thioguanine (6-TG).	Thioguanine	126-139	BRCA1 DNA repair associated	Homo sapiens	32-37
29156686-4	2017	AGS cells over-expressing Polbeta were resistant to 6-TG to a similar extent as when MLH1 was inactivated while inhibition of O6-methylguanine-DNA methyltransferase (MGMT) was required to detect resistance to MMS.	Thioguanine	52-56	DNA polymerase beta	Homo sapiens	26-33
29156686-6	2017	Moreover, AGS cells mutated in Polbeta were hypersensitive to both 6-TG and MMS killing and their sensitivity was partially rescued by MLH1 silencing.	Thioguanine	67-71	DNA polymerase beta	Homo sapiens	31-38
27313062-4	2016	However, unexpectedly, only two BRCA1-mutant cell lines, HCC1937 and MDA-MB-436, were hypersensitive to a nucleotide analogue 6-thioguanine (6-TG).	Thioguanine	141-145	BRCA1 DNA repair associated	Homo sapiens	32-37
26819003-10	2016	In silico experiments demonstrate that reduced prothrombin conversion and to a lesser extent elevated alpha2M levels provide an explanation for low TG in children.	Thioguanine	148-150	coagulation factor II, thrombin	Homo sapiens	47-58
27267043-0	2016	The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of beta cell function in a Chinese population with different glucose tolerance status.	Thioguanine	58-60	insulin	Homo sapiens	92-99
27216972-4	2016	The mRNA level of HMG-CoAR was significantly positively correlated with the hepatic TG content (r = 0.82, P &lt; 0.05).	Thioguanine	84-86	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	18-26
26819003-10	2016	In silico experiments demonstrate that reduced prothrombin conversion and to a lesser extent elevated alpha2M levels provide an explanation for low TG in children.	Thioguanine	148-150	alpha-2-macroglobulin	Homo sapiens	102-109
26762195-7	2016	Blockade of the IL-6-signalling suppressed SC activation around PCa precursor lesions (pancreatic intraepithelial neoplasia (PanIN)) in KC;IL6(-/-) (32.06%+-5.25% of PanINs) and KC;sgp130(tg) (55.84%+-5.51%) mouse models compared with KC mice (78.27%+-3.91%).	Thioguanine	188-190	interleukin 6	Mus musculus	16-20
27279841-6	2016	RESULTS: Although both PUFA sources were able to improve TG plasma levels, esterified omega 3 PUFAs were more efficacious than krill oil (p &lt; 0.05).	Thioguanine	57-59	pumilio RNA binding family member 3	Homo sapiens	23-27
26297310-3	2016	TPMT is one of the important metabolic enzymes of phase II metabolic pathway and catalyzes methylation of thiopurine drugs such as azathioprine, 6-thioguanine and 6-mercaptopurine, which are used to treat patients with neoplasia and autoimmune disease as well as transplant recipients.	Thioguanine	145-158	thiopurine S-methyltransferase	Homo sapiens	0-4
26661159-6	2016	Infarct volume was significantly greater with enhanced reactive oxygen species production and blood-brain barrier breakdown in peri-infarct areas in Tg-Nox4, compared with littermate controls.	Thioguanine	149-151	NADPH oxidase 4	Mus musculus	152-156
27020734-1	2016	BACKGROUND: The management of patients with differentiated thyroid carcinoma (DTC) showing low levels of serum thyroglobulin autoantibodies (TgAb) and undetectable Tg after thyroidectomy is unsettled.	Thioguanine	141-143	thyroglobulin	Homo sapiens	111-124
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	125-127	acetylcholinesterase	Mus musculus	27-47
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	125-127	acetylcholinesterase	Mus musculus	49-53
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	125-127	BCL2-associated X protein	Mus musculus	68-71
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	125-127	B cell leukemia/lymphoma 2	Mus musculus	72-77
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	acetylcholinesterase	Mus musculus	27-47
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	acetylcholinesterase	Mus musculus	49-53
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	BCL2-associated X protein	Mus musculus	68-71
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	B cell leukemia/lymphoma 2	Mus musculus	72-77
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	acetylcholinesterase	Mus musculus	27-47
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	acetylcholinesterase	Mus musculus	49-53
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	BCL2-associated X protein	Mus musculus	68-71
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	B cell leukemia/lymphoma 2	Mus musculus	72-77
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	acetylcholinesterase	Mus musculus	27-47
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	acetylcholinesterase	Mus musculus	49-53
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	BCL2-associated X protein	Mus musculus	68-71
27382379-4	2016	Significant suppression of acetylcholinesterase (AChE) activity and Bax/Bcl-2 expression was also observed in the DG treated TG mice (TG+DG group) when compared with those of the vehicle (VC) treated TG mice (TG+VC group).	Thioguanine	134-136	B cell leukemia/lymphoma 2	Mus musculus	72-77
27382379-6	2016	Furthermore, the decreased phosphorylation of downstream members in the TrkA high affinity receptor signaling pathway in the TG+VC group was significantly recovered in the TG+DG group.	Thioguanine	125-127	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	72-76
27382379-6	2016	Furthermore, the decreased phosphorylation of downstream members in the TrkA high affinity receptor signaling pathway in the TG+VC group was significantly recovered in the TG+DG group.	Thioguanine	172-174	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	72-76
28290840-11	2016	In patients with Lp(a) concentration less or equal 30 mg/dl subfractions of sdLDL were directly related to TG.	Thioguanine	107-109	lipoprotein(a)	Homo sapiens	17-21
28290840-14	2016	sdLDL content&gt;2 mg/l or hypertriglyceridemia (TG&gt;1.7 mmol/l) significantly increase chances of detection of confirmed IHD in patients with elevated Lp(a).	Thioguanine	49-51	lipoprotein(a)	Homo sapiens	154-158
27138327-12	2016	The active isoform of MMP-2 was higher activity in TG at 14 days.	Thioguanine	51-53	matrix metallopeptidase 2	Rattus norvegicus	22-27
27196668-8	2016	Importantly, drugs which increase phosphorylation of eIF2alpha may mimic the sensitizing effect of vorinostat on cellular response to PARPis or to 6-TG, without activating all of its downstream effectors.	Thioguanine	147-151	eukaryotic translation initiation factor 2A	Homo sapiens	53-62
27203747-9	2016	The risk of high TChol, LDL-chol, non-HDL-chol and TG, and low HDL-chol levels also decreased in AST/ALT ratio groups.	Thioguanine	51-53	solute carrier family 17 member 5	Homo sapiens	97-100
26975374-9	2016	Knockdown of USP10 in lung cancer cells exhibits increased cell survival and decreased apoptosis upon the treatment of DNA-methylating agent N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and antimetabolite 6-thioguanine (6-TG).	Thioguanine	204-217	ubiquitin specific peptidase 10	Homo sapiens	13-18
26975374-9	2016	Knockdown of USP10 in lung cancer cells exhibits increased cell survival and decreased apoptosis upon the treatment of DNA-methylating agent N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and antimetabolite 6-thioguanine (6-TG).	Thioguanine	219-223	ubiquitin specific peptidase 10	Homo sapiens	13-18
26974491-6	2016	AT-independent thrombin inhibitors, melagatran and dabigatran (both at 25-600nM) and 3-30mug/ml active site-blocked thrombin (IIai), increased peak levels of TG.	Thioguanine	158-160	coagulation factor II, thrombin	Homo sapiens	15-23
26558335-8	2016	CONCLUSION: Both FXI concentrates improve TG in vitro in major FXI deficiency but differ in dose response, and for both products, doses lower than previously recommended normalized TG in vitro.	Thioguanine	42-44	coagulation factor XI	Homo sapiens	17-20
26874765-6	2016	were found to increase with higher delta(15)N and lower delta(13)C. The southern Beaufort Sea exhibited both the highest THg and MMHg concentrations.	Thioguanine	121-124	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	90-93
26662568-4	2016	Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60-0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72-0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65-0.94).	Thioguanine	116-118	interleukin 27	Homo sapiens	31-36
26662568-4	2016	Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60-0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72-0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65-0.94).	Thioguanine	237-239	interleukin 27	Homo sapiens	31-36
27115999-0	2016	Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus.	Thioguanine	49-51	insulin	Homo sapiens	63-70
27115999-1	2016	OBJECTIVES: To explore the association between the triglyceride to HDL-C ratio (TG/HDL-C) and insulin resistance in Chinese patients with newly diagnosed type 2 diabetes mellitus.	Thioguanine	80-82	insulin	Homo sapiens	94-101
27104558-12	2016	Furthermore, we observed that insulin promoted intracellular TG deposits in hepatocytes in the present of palmitate.	Thioguanine	61-63	insulin	Homo sapiens	30-37
28331736-8	2016	RESULTS: Adiponectin 45T/G gene genotype frequencies of TT, TG, and GG were 61.9%, 37.1%, and 1% in patients with breast cancer, and 67.3%, 30.7%, and 2% in the control group, respectively.	Thioguanine	60-62	adiponectin, C1Q and collagen domain containing	Homo sapiens	9-20
26850368-3	2016	The enzymatic activities of GPx and glutathione reductase were significantly decreased in non-TG mice, whereas superoxide dismutase was increased in the early phase of cocaine exposure.	Thioguanine	94-96	glutathione reductase	Mus musculus	36-57
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	8-10	platelet factor 4	Mus musculus	0-3
27037360-10	2016	Moreover, we showed that, just like MSH2-deficient cells, depletion of WDHD1 also led to 6-thioguanine (6-TG) resistance, indicating that WDHD1 likely contributes to the MMR pathway.	Thioguanine	89-102	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	71-76
27037360-10	2016	Moreover, we showed that, just like MSH2-deficient cells, depletion of WDHD1 also led to 6-thioguanine (6-TG) resistance, indicating that WDHD1 likely contributes to the MMR pathway.	Thioguanine	104-108	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	71-76
27037360-10	2016	Moreover, we showed that, just like MSH2-deficient cells, depletion of WDHD1 also led to 6-thioguanine (6-TG) resistance, indicating that WDHD1 likely contributes to the MMR pathway.	Thioguanine	104-108	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	138-143
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	8-10	lysyl oxidase	Mus musculus	4-7
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	11-13	platelet factor 4	Mus musculus	0-3
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	11-13	lysyl oxidase	Mus musculus	4-7
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	11-13	platelet factor 4	Mus musculus	0-3
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	11-13	lysyl oxidase	Mus musculus	4-7
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	11-13	platelet factor 4	Mus musculus	0-3
26755713-4	2016	Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time to vessel occlusion after endothelial injury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus formation in vivo.	Thioguanine	11-13	lysyl oxidase	Mus musculus	4-7
26680362-4	2016	mTORC1 hyperactivation induced the expression of lipogenic (DGAT1 and DGAT2) and lipoprotein assembly (MTP and APOB) genes, thereby raising cellular triacylglyceride (TG) and exacerbating secretion of apoB-containing TG-rich lipoproteins.	Thioguanine	167-169	CREB regulated transcription coactivator 1	Mus musculus	0-6
26805007-3	2016	Initial biochemical and gene expression studies suggested that deficiency in CoA might underlie reduced TG synthesis in animals during chronic HS feeding.	Thioguanine	104-106	Coa	Drosophila melanogaster	77-80
26658238-2	2016	Herein, we have used a non-steady-state experimental design to examine the role of cholesteryl ester transfer protein (CETP) in mediating HDL-TG flux in vivo in rhesus macaques, and therefore, we developed an alternative strategy to model the data.	Thioguanine	142-144	cholesteryl ester transfer protein	Macaca mulatta	83-117
26818679-3	2016	Here, we investigate whether CREM repressors contribute to the arrhythmogenic remodeling in the heart by analyzing arrhythmogenic alterations in ventricular cardiomyocytes (VCMs) from mice with transgenic expression of the CREM repressor isoform CREM-IbDeltaC-X (TG).	Thioguanine	263-265	cAMP responsive element modulator	Mus musculus	223-227
26818679-3	2016	Here, we investigate whether CREM repressors contribute to the arrhythmogenic remodeling in the heart by analyzing arrhythmogenic alterations in ventricular cardiomyocytes (VCMs) from mice with transgenic expression of the CREM repressor isoform CREM-IbDeltaC-X (TG).	Thioguanine	263-265	cAMP responsive element modulator	Mus musculus	223-227
26658238-2	2016	Herein, we have used a non-steady-state experimental design to examine the role of cholesteryl ester transfer protein (CETP) in mediating HDL-TG flux in vivo in rhesus macaques, and therefore, we developed an alternative strategy to model the data.	Thioguanine	142-144	cholesteryl ester transfer protein	Macaca mulatta	119-123
26805007-7	2016	Dietary supplementation with pantothenic acid (vitamin B5, a precursor of CoA) was able to ameliorate HS-diet-induced FFA accumulation and hyperglycemia while increasing TG synthesis.	Thioguanine	170-172	Coa	Drosophila melanogaster	74-77
26658238-5	2016	Based on our data, we estimate that the peak total postprandial TG flux to HDL via CETP is ~ 13 mg   h(-1)   kg(-1) and show that this transfer was inhibited by 97% following anacetrapib treatment.	Thioguanine	64-66	cholesteryl ester transfer protein	Homo sapiens	83-87
25582650-1	2016	OBJECTIVE: To investigate the relationship between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and carotid intima-medial thickness (CIMT) in Chinese youth and adolescents with newly diagnosed type 2 diabetes mellitus (T2DM).	Thioguanine	105-107	CIMT	Homo sapiens	158-162
25582650-5	2016	In general linear regression model, TG/HDL-C was an independent determinant of CIMT even after adjusting for BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, HbA1c and HOMA-IR.	Thioguanine	36-38	CIMT	Homo sapiens	79-83
25582650-5	2016	In general linear regression model, TG/HDL-C was an independent determinant of CIMT even after adjusting for BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, HbA1c and HOMA-IR.	Thioguanine	36-38	component of oligomeric golgi complex 2	Homo sapiens	132-137
26763404-4	2016	Oral administration of TG (270 mg/kg) induced significant elevation in the levels of serum alanine / aspartate transaminase (ALT/AST), hepatic malondialdehyde (MDA) and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) (all P &lt; 0.01).	Thioguanine	23-25	glutamic pyruvic transaminase, soluble	Mus musculus	125-128
26965176-15	2016	The expression of adiponectin attenuated the increases of serum TC (P &lt; 0.001), TG (P &lt; 0.001), and LDL-C (P &lt; 0.001) induced by the high-fat diet, and the increase in body weight (P &lt; 0.05).	Thioguanine	83-85	adiponectin, C1Q and collagen domain containing	Mus musculus	18-29
26873362-12	2016	There were potential interactions among CDKN2A/2B (rs10811661) - FTO (rs7195539) or FTO (rs7195539)-TG-HDL-family history of diabetes in the pathogenesis of T2D in a Uyghur population.	Thioguanine	100-102	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	84-87
26564145-9	2016	Moreover, for the apoptosis signal pathway, pretreatment with TG markedly decreased the expression of caspase-3 and Bax and increased the level of Bcl-2.	Thioguanine	62-64	caspase 3	Rattus norvegicus	102-111
26564145-9	2016	Moreover, for the apoptosis signal pathway, pretreatment with TG markedly decreased the expression of caspase-3 and Bax and increased the level of Bcl-2.	Thioguanine	62-64	BCL2 associated X, apoptosis regulator	Rattus norvegicus	116-119
26564145-9	2016	Moreover, for the apoptosis signal pathway, pretreatment with TG markedly decreased the expression of caspase-3 and Bax and increased the level of Bcl-2.	Thioguanine	62-64	BCL2, apoptosis regulator	Rattus norvegicus	147-152
26069184-6	2016	Similar to McK-DeltaH2, dLAT-DeltaH2 expressed more ICP0, was more neurovirulent, and had increased reactivation in the mouse TG explant-induced reactivation model of HSV-1 compared with its parental virus.	Thioguanine	126-128	Origin recognition complex subunit 3	Drosophila melanogaster	24-28
26069184-7	2016	Interestingly, although the increased reactivation of McK-DeltaH2 compared with its parental wild-type (wt) virus was subtle and only detected at very early times after explant TG induced reactivation, the increased reactivation of dLAT-DeltaH2 compared with its dLAT2903 parental virus appeared more robust and was significantly increased even at late times after induction.	Thioguanine	177-179	creatine kinase, M-type	Homo sapiens	54-57
26763404-4	2016	Oral administration of TG (270 mg/kg) induced significant elevation in the levels of serum alanine / aspartate transaminase (ALT/AST), hepatic malondialdehyde (MDA) and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) (all P &lt; 0.01).	Thioguanine	23-25	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	129-132
26280645-12	2016	Analysis of the polymorphism rs613872 in intron 3 of the TCF4 gene exhibited 33 of 42 unrelated patients (78.6 %) heterozygous TG and four homozygous GG (9.5 %).	Thioguanine	127-129	transcription factor 4	Homo sapiens	57-61
26763404-4	2016	Oral administration of TG (270 mg/kg) induced significant elevation in the levels of serum alanine / aspartate transaminase (ALT/AST), hepatic malondialdehyde (MDA) and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) (all P &lt; 0.01).	Thioguanine	23-25	tumor necrosis factor	Mus musculus	195-222
26763404-4	2016	Oral administration of TG (270 mg/kg) induced significant elevation in the levels of serum alanine / aspartate transaminase (ALT/AST), hepatic malondialdehyde (MDA) and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) (all P &lt; 0.01).	Thioguanine	23-25	tumor necrosis factor	Mus musculus	224-233
26786966-2	2016	Turnbull argued that tauX* should increase rapidly with the dimensionless ratio trg=Tg/TL.	Thioguanine	84-86	T cell receptor gamma locus	Homo sapiens	80-83
26231230-6	2016	Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver.	Thioguanine	16-18	cystathionine beta-synthase	Mus musculus	25-28
27936341-7	2016	Through multiple logistic regression analysis, the adiponectin +276 T allele carrier was found to be associated with an increased risk of hypertension (TT vs. GG and TG: odds ratio = 3.318, p = 0.014, 95% confidence interval: 1.269-8.678).	Thioguanine	166-168	adiponectin, C1Q and collagen domain containing	Homo sapiens	51-62
27543774-13	2016	In immunohistochemical sections, c-FOS positivity was decreased in the NTG and especially the TG.	Thioguanine	72-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-38
27543774-14	2016	Otherwise, PGC-1  positive cells were increased in the NTG and especially the TG.	Thioguanine	56-58	PPARG coactivator 1 alpha	Sus scrofa	11-16
26231230-6	2016	Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver.	Thioguanine	16-18	betaine-homocysteine methyltransferase	Mus musculus	75-124
26231230-6	2016	Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver.	Thioguanine	16-18	betaine-homocysteine methyltransferase	Mus musculus	126-130
26231230-6	2016	Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver.	Thioguanine	16-18	stearoyl-Coenzyme A desaturase 1	Mus musculus	206-211
26231230-8	2016	Surprisingly, betaine supplementation had several negative effects in control Tg-I278T Cbs (+/-) mice including decreased weight gain, lean mass, and bone mineral density.	Thioguanine	78-80	cystathionine beta-synthase	Mus musculus	87-90
27340342-8	2016	(IV) Correlations were found for LV dimensions with IL-6 (74%, p &lt; 0.001) and TNFalpha (52%, p &lt; 0.001) and fully abolished after TG and Q10 control.	Thioguanine	136-138	interleukin 6	Rattus norvegicus	52-56
27340342-8	2016	(IV) Correlations were found for LV dimensions with IL-6 (74%, p &lt; 0.001) and TNFalpha (52%, p &lt; 0.001) and fully abolished after TG and Q10 control.	Thioguanine	136-138	tumor necrosis factor	Rattus norvegicus	81-89
26666260-8	2015	Correlations between the CAP lesion size and LpPLA2 mass and between the CAP lesion size and TG level in patients with apoAI 150 &lt;= mg/dL showed increase TG in atherogenic apoB-containing triglyceride-rich lipoprotein and TC in cholesterol-rich lipoprotein.	Thioguanine	93-95	apolipoprotein A1	Homo sapiens	119-124
26553130-10	2016	TG treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared with the saline gel control group (p &lt; 0.05).	Thioguanine	0-2	myeloperoxidase	Rattus norvegicus	74-89
26666260-8	2015	Correlations between the CAP lesion size and LpPLA2 mass and between the CAP lesion size and TG level in patients with apoAI 150 &lt;= mg/dL showed increase TG in atherogenic apoB-containing triglyceride-rich lipoprotein and TC in cholesterol-rich lipoprotein.	Thioguanine	93-95	apolipoprotein B	Homo sapiens	175-179
26666260-8	2015	Correlations between the CAP lesion size and LpPLA2 mass and between the CAP lesion size and TG level in patients with apoAI 150 &lt;= mg/dL showed increase TG in atherogenic apoB-containing triglyceride-rich lipoprotein and TC in cholesterol-rich lipoprotein.	Thioguanine	157-159	phospholipase A2 group VII	Homo sapiens	45-51
26666260-8	2015	Correlations between the CAP lesion size and LpPLA2 mass and between the CAP lesion size and TG level in patients with apoAI 150 &lt;= mg/dL showed increase TG in atherogenic apoB-containing triglyceride-rich lipoprotein and TC in cholesterol-rich lipoprotein.	Thioguanine	157-159	apolipoprotein A1	Homo sapiens	119-124
26666260-8	2015	Correlations between the CAP lesion size and LpPLA2 mass and between the CAP lesion size and TG level in patients with apoAI 150 &lt;= mg/dL showed increase TG in atherogenic apoB-containing triglyceride-rich lipoprotein and TC in cholesterol-rich lipoprotein.	Thioguanine	157-159	apolipoprotein B	Homo sapiens	175-179
26659465-7	2015	Moreover, the concentrations of serum TG, TC, HDL-C, LDL-C, VLDL-C and FFA were significantly increased by CCl4.	Thioguanine	38-40	C-C motif chemokine ligand 4	Rattus norvegicus	107-111
26816879-3	2015	Most clinical laboratories determine LDL-C (mg/dL) by Friedewald"s formula (FF), LDL-C = (TC) - (HDL-C) - (TG/5).	Thioguanine	107-109	component of oligomeric golgi complex 2	Homo sapiens	81-86
26816879-4	2015	Recently Anandaraja and colleagues have derived a new formula for calculating LDL-C, AR-LDL-C = 0.9 TC- (0.9 TG/5)-28.	Thioguanine	109-111	component of oligomeric golgi complex 2	Homo sapiens	78-83
26816879-4	2015	Recently Anandaraja and colleagues have derived a new formula for calculating LDL-C, AR-LDL-C = 0.9 TC- (0.9 TG/5)-28.	Thioguanine	109-111	component of oligomeric golgi complex 2	Homo sapiens	88-93
26816879-5	2015	AIM &amp; OBJECTIVES: The aim of the study was: a) to determine if, and to what extent, LDL-C level was underestimated/overestimated when it was calculated using the formulae compared with direct measurement of LDL-C, and b) to determine which of the calculated formulae show maximum correlation with direct LDL cholesterol method at different TG levels.	Thioguanine	344-346	component of oligomeric golgi complex 2	Homo sapiens	88-93
26109679-4	2015	Similar to humans with loss-of-function mutations in ATGL, we found that global and myeloid-specific Atgl(-/-) mice exhibit Jordans" anomaly with increased abundance of intracellular TG-rich LDs in neutrophil granulocytes.	Thioguanine	54-56	patatin like phospholipase domain containing 2	Homo sapiens	101-105
26410295-6	2015	The lowest observed effective concentration (LOEC) of TCDD was estimated to be ~1 pM and the EC50 (effective concentration to induce GFP in 50 % of Tg(cyp1a:gfp) larvae) was ~10 pM.	Thioguanine	148-150	cytochrome P450, family 1, subfamily A	Danio rerio	151-156
26910996-6	2015	The accumulation ability of dominant plants in WLFZ for THg (bioaccumulation factor, BAF &lt; 1) was weaker than that for MeHg (BAF &gt; 1).	Thioguanine	56-59	BAF nuclear assembly factor 1	Homo sapiens	85-88
26823702-4	2015	Three of those six biomarkers (LACT, IDO, and TNF-beta) were moderately accurate in discriminating TG from NG, individually and in combination, according to ROC analysis (AUC = 0.7-0.89, sensitivity = 55.6-77.8%, specificity = 71.0-100%).	Thioguanine	99-101	indoleamine 2,3-dioxygenase 1	Homo sapiens	37-40
26823702-4	2015	Three of those six biomarkers (LACT, IDO, and TNF-beta) were moderately accurate in discriminating TG from NG, individually and in combination, according to ROC analysis (AUC = 0.7-0.89, sensitivity = 55.6-77.8%, specificity = 71.0-100%).	Thioguanine	99-101	lymphotoxin alpha	Homo sapiens	46-54
26823702-5	2015	Our data indicate that selected immunohistochemical markers (LACT, IDO, and TNF-beta) can be used in ancillary tests to differentiate TG from NG in tissue samples.	Thioguanine	134-136	indoleamine 2,3-dioxygenase 1	Homo sapiens	67-70
26823702-5	2015	Our data indicate that selected immunohistochemical markers (LACT, IDO, and TNF-beta) can be used in ancillary tests to differentiate TG from NG in tissue samples.	Thioguanine	134-136	lymphotoxin alpha	Homo sapiens	76-84
26374996-5	2015	Norepinephrine-mediated myocardial blood flow (MBF) was significantly enhanced in SOD2-tg mice.	Thioguanine	87-89	superoxide dismutase 2, mitochondrial	Mus musculus	82-86
26130722-6	2015	HPRT targeted cells are selected by resistance to 6-thioguanine (6-TG) and then examined for potential alterations to the gene targeted by the co-transfected guide RNA.	Thioguanine	50-63	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-4
26130722-6	2015	HPRT targeted cells are selected by resistance to 6-thioguanine (6-TG) and then examined for potential alterations to the gene targeted by the co-transfected guide RNA.	Thioguanine	65-69	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-4
26130722-7	2015	Alterations of many genes, such as AAVS1, Exo1 and Trex1, are highly enriched in the 6-TG resistant cells.	Thioguanine	85-89	adeno-associated virus integration site 1	Homo sapiens	35-40
26130722-7	2015	Alterations of many genes, such as AAVS1, Exo1 and Trex1, are highly enriched in the 6-TG resistant cells.	Thioguanine	85-89	exonuclease 1	Homo sapiens	42-46
26130722-7	2015	Alterations of many genes, such as AAVS1, Exo1 and Trex1, are highly enriched in the 6-TG resistant cells.	Thioguanine	85-89	three prime repair exonuclease 1	Homo sapiens	51-56
26343845-4	2015	Importantly, ratio of BH4 to 7,8-BH2, indicative of BH4 available for eNOS activation, was significantly increased in eGCH-Tg mice.	Thioguanine	123-125	immunoglobulin kappa variable 1-131	Mus musculus	33-36
26637972-5	2015	Fat-1 mice exhibited significantly lower levels of total hepatic/plasma TG and plasma alanine aminotransferase activity.	Thioguanine	72-74	FAT atypical cadherin 1	Mus musculus	0-5
26318157-5	2015	We found that hepatic hMsrA expression significantly reduced plasma VLDL/LDL levels, improved plasma superoxide dismutase, and paraoxonase-1 activities, and decreased plasma serum amyloid A level in apoE(-/-) mice fed a Western diet, by significantly altering the expression of several genes in the liver involving cholesterol selective uptake, conversion and excretion into bile, TG biosynthesis, and inflammation.	Thioguanine	381-383	methionine sulfoxide reductase A	Homo sapiens	22-27
26436984-7	2015	In the presence of TAC, scavenging of reactive oxygen species with N-acetylcysteine reduced eNOS S-glutathionylation, eNOS monomer and NOS-dependent superoxide levels in eNOS-Tg mice to wildtype levels.	Thioguanine	175-177	nitric oxide synthase 3, endothelial cell	Mus musculus	92-96
26436984-7	2015	In the presence of TAC, scavenging of reactive oxygen species with N-acetylcysteine reduced eNOS S-glutathionylation, eNOS monomer and NOS-dependent superoxide levels in eNOS-Tg mice to wildtype levels.	Thioguanine	175-177	nitric oxide synthase 3, endothelial cell	Mus musculus	118-122
26436984-7	2015	In the presence of TAC, scavenging of reactive oxygen species with N-acetylcysteine reduced eNOS S-glutathionylation, eNOS monomer and NOS-dependent superoxide levels in eNOS-Tg mice to wildtype levels.	Thioguanine	175-177	nitric oxide synthase 3, endothelial cell	Mus musculus	118-122
26436984-8	2015	Accordingly, N-acetylcysteine improved cardiac function in eNOS-Tg but not in wildtype mice with TAC.	Thioguanine	64-66	nitric oxide synthase 3, endothelial cell	Mus musculus	59-63
26439934-8	2015	Our data suggest that compared with the rs2919872 G allele, the rs2919872 A allele reduces the transcriptional activity of FABP1 promoter, and thereby may link FABP1 gene variation to TG level in humans.	Thioguanine	184-186	fatty acid binding protein 1	Homo sapiens	160-165
26452348-11	2015	And HDL-apoCIII correlated with plasma TG significantly in non-CHD and CHD patients (p &lt; 0.05), but the correlation in CHD patients did not exist after statin treatment (p &gt; 0.05).	Thioguanine	39-41	apolipoprotein C3	Homo sapiens	8-15
26439934-5	2015	Results showed that only the rs2919872 G&gt;A variant was significantly associated with serum TG concentration(P = 0.032).Compared with the rs2919872 G allele, rs2919872 A allele contributed significantly to reduced serum TG concentration, and this allele dramatically decreased the FABP1 promoter activity(P &lt; 0.05).	Thioguanine	94-96	fatty acid binding protein 1	Homo sapiens	283-288
26439934-8	2015	Our data suggest that compared with the rs2919872 G allele, the rs2919872 A allele reduces the transcriptional activity of FABP1 promoter, and thereby may link FABP1 gene variation to TG level in humans.	Thioguanine	184-186	fatty acid binding protein 1	Homo sapiens	123-128
25905405-8	2000	TPO sits at the apical plasma membrane, where it reduces H2O2, elevating the oxidation state of iodide to an iodinating species, and attaches the iodine to tyrosyls in Tg.	Thioguanine	168-170	thyroid peroxidase	Homo sapiens	0-3
26448026-10	2015	Adropin had a negative correlation with DBP (r = -0.40, P &lt; 0.001), SBP (r = -0.49, P &lt; 0.001), and adjusted for age, body mass index, SBP, DBP, glucose, TC, TG, LDL, and Cr, there was a negative correlation between ET-1 and adropin (r = -0.20, P = 0.04).	Thioguanine	164-166	energy homeostasis associated	Homo sapiens	0-7
26527331-7	2015	RESULTS: In the Tg-TE group that was subjected to treadmill exercise for 12 weeks, abnormal mTOR phosphorylation of PI3K/AKT proteins was improved via increased phosphorylation and its activity was inhibited by increased GSK-3beta phosphorylation compared with those in the Tg-CON group, which was used as the control group.	Thioguanine	16-18	mechanistic target of rapamycin kinase	Mus musculus	92-96
26232164-1	2015	BACKGROUND: High levels of the triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio are associated with obesity, metabolic syndrome, and insulin resistance.	Thioguanine	86-88	insulin	Homo sapiens	155-162
25817768-2	2015	The promoter, coding regions and intron-exon boundaries of LMF1 were sequenced in 112 patients with severe primary hipertrigliceridemia (defined as TG above 500mg/dl).	Thioguanine	148-150	lipase maturation factor 1	Homo sapiens	59-63
26162609-9	2015	The negative prognostic effect associated with KRAS mutation appeared to be stronger in patients with the LCS-6 TT genotype (HR PFS 1.70, P = 0.078; HR OS 1.79, P = 0.082) compared with those with the LCS-6 TG genotype (HR PFS 1.33, P = 0.713; HR OS 1.01, P = 0.995).	Thioguanine	207-209	KRAS proto-oncogene, GTPase	Homo sapiens	47-51
26280928-3	2015	The results showed that CDP, CDS, CDO and CDL significantly increased the serum TC, LDL-C levels and liver TG, TC levels at dose of 16.5mumol/kg/day.	Thioguanine	107-109	cysteine dioxygenase 1, cytosolic	Mus musculus	34-37
26617894-5	2015	We found that individuals carrying with GT+TT genotype of ERCC1 rs3212986 and TG+GG genotype of ERCC2 rs1318 gene polymorphisms were correlated with higher risk of pancreatic cancer in smokers when compared with non-smokers, and the adjusted ORs (95% CI) were 1.89 (1.05-3.40) and 1.88 (1.06-3.34), respectively.	Thioguanine	78-80	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	96-101
26527331-7	2015	RESULTS: In the Tg-TE group that was subjected to treadmill exercise for 12 weeks, abnormal mTOR phosphorylation of PI3K/AKT proteins was improved via increased phosphorylation and its activity was inhibited by increased GSK-3beta phosphorylation compared with those in the Tg-CON group, which was used as the control group.	Thioguanine	16-18	thymoma viral proto-oncogene 1	Mus musculus	121-124
26527331-7	2015	RESULTS: In the Tg-TE group that was subjected to treadmill exercise for 12 weeks, abnormal mTOR phosphorylation of PI3K/AKT proteins was improved via increased phosphorylation and its activity was inhibited by increased GSK-3beta phosphorylation compared with those in the Tg-CON group, which was used as the control group.	Thioguanine	16-18	glycogen synthase kinase 3 beta	Mus musculus	221-230
26527331-8	2015	In addition, the expression of Beclin-1 protein involved in autophagosome formation was increased in the Tg-TE group compared with that in the Tg-CON group, whereas that of p62 protein was reduced in the Tg-TE group compared with that in the Tg-CON group.	Thioguanine	105-107	beclin 1, autophagy related	Mus musculus	31-39
26527331-8	2015	In addition, the expression of Beclin-1 protein involved in autophagosome formation was increased in the Tg-TE group compared with that in the Tg-CON group, whereas that of p62 protein was reduced in the Tg-TE group compared with that in the Tg-CON group.	Thioguanine	143-145	beclin 1, autophagy related	Mus musculus	31-39
26203075-1	2015	We previously reported that reducing the expression of cholesteryl ester transfer protein (CETP) disrupts cholesterol homeostasis in SW872 cells and causes an ~50% reduction in TG.	Thioguanine	177-179	cholesteryl ester transfer protein	Homo sapiens	55-89
26527331-8	2015	In addition, the expression of Beclin-1 protein involved in autophagosome formation was increased in the Tg-TE group compared with that in the Tg-CON group, whereas that of p62 protein was reduced in the Tg-TE group compared with that in the Tg-CON group.	Thioguanine	143-145	beclin 1, autophagy related	Mus musculus	31-39
26203075-1	2015	We previously reported that reducing the expression of cholesteryl ester transfer protein (CETP) disrupts cholesterol homeostasis in SW872 cells and causes an ~50% reduction in TG.	Thioguanine	177-179	cholesteryl ester transfer protein	Homo sapiens	91-95
26160049-10	2015	The major part of dnDSA-associated TG was C1q-negative and the presence of C1q-fixing dnDSA did not significantly correlate with graft outcome.	Thioguanine	35-37	complement C1q A chain	Homo sapiens	42-45
26203075-8	2015	Overall, these data suggest that the decreased TG content of CETP-deficient cells arises from the reduced conversion of DG to TG in the ER and/or on the lipid droplet surface, and enhanced TG degradation in the ER due to its ineffective transport from this organelle.	Thioguanine	47-49	cholesteryl ester transfer protein	Homo sapiens	61-65
26203075-8	2015	Overall, these data suggest that the decreased TG content of CETP-deficient cells arises from the reduced conversion of DG to TG in the ER and/or on the lipid droplet surface, and enhanced TG degradation in the ER due to its ineffective transport from this organelle.	Thioguanine	126-128	cholesteryl ester transfer protein	Homo sapiens	61-65
26203075-8	2015	Overall, these data suggest that the decreased TG content of CETP-deficient cells arises from the reduced conversion of DG to TG in the ER and/or on the lipid droplet surface, and enhanced TG degradation in the ER due to its ineffective transport from this organelle.	Thioguanine	126-128	cholesteryl ester transfer protein	Homo sapiens	61-65
26136510-8	2015	After stratification on the n-3 LC-PUFA median values, the association between rs1260326 and TG concentration was significant only in the group with high n-3 LC-PUFA levels.	Thioguanine	93-95	pumilio RNA binding family member 3	Homo sapiens	35-39
26136510-8	2015	After stratification on the n-3 LC-PUFA median values, the association between rs1260326 and TG concentration was significant only in the group with high n-3 LC-PUFA levels.	Thioguanine	93-95	pumilio RNA binding family member 3	Homo sapiens	161-165
26136510-9	2015	In conclusion, this is the first evidence that n-3 LC-PUFAs may modulate the impact of the GCKR rs1260326 polymorphism on TG concentrations in adolescents.	Thioguanine	122-124	glucokinase regulator	Homo sapiens	91-95
26244076-1	2015	BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels.	Thioguanine	145-147	apolipoprotein A5	Homo sapiens	22-39
26060059-6	2015	The IL28B rs8099917/rs12979860 TT/CC genotype was the most frequent in MC-positive patients with sustained virological response (SVR) (p &lt; 0.001), while the TG/TC genotype was most frequent in non-SVR (p &lt; 0.001).	Thioguanine	160-162	interferon lambda 3	Homo sapiens	4-9
26060059-9	2015	IL28B rs8099917/rs12979860 is useful in the treatment of MC-positive HCV patients with PEG-IFN and ribavirin; the TT/CC genotype is associated with SVR, the TG/TC with non-SVR; TT/CC is also predictive of MC in HCV patients.	Thioguanine	157-159	interferon lambda 3	Homo sapiens	0-5
26193853-5	2015	Pro-atherogenic phenotype of LCHP fed apoE/LDLR-/- mice was associated with increased plasma total cholesterol concentration, and in LDL and VLDL fractions, increased TG contents in VLDL, and a modest increase in plasma urea.	Thioguanine	167-169	apolipoprotein E	Mus musculus	38-42
26244076-1	2015	BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels.	Thioguanine	145-147	apolipoprotein A5	Homo sapiens	83-88
26244076-1	2015	BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels.	Thioguanine	145-147	apolipoprotein A5	Homo sapiens	225-230
26244076-1	2015	BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels.	Thioguanine	269-271	apolipoprotein A5	Homo sapiens	22-39
26244076-1	2015	BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels.	Thioguanine	269-271	apolipoprotein A5	Homo sapiens	83-88
26244076-8	2015	In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels.	Thioguanine	97-99	apolipoprotein A5	Homo sapiens	36-41
26244076-8	2015	In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels.	Thioguanine	218-220	apolipoprotein A5	Homo sapiens	36-41
26244076-9	2015	CONCLUSIONS: The genetic effects of APOA5 T-1131C independently affected plasma TG levels.	Thioguanine	80-82	apolipoprotein A5	Homo sapiens	36-41
26048399-10	2015	Multiple linear regression adjusted for age, gender, body mass index and fibrinogen showed that TG (beta=-0.41), vWF (beta=-0.29) and PF4 (beta=-0.28) are the independent predictors of Ks (R(2)=0.78), while CLT was independently predicted by TG (beta=0.37), PAI-1 antigen (beta=0.29) and vWF (beta=0.26) in the AF group (R(2)=0.39).	Thioguanine	96-98	serpin family E member 1	Homo sapiens	258-263
26048399-10	2015	Multiple linear regression adjusted for age, gender, body mass index and fibrinogen showed that TG (beta=-0.41), vWF (beta=-0.29) and PF4 (beta=-0.28) are the independent predictors of Ks (R(2)=0.78), while CLT was independently predicted by TG (beta=0.37), PAI-1 antigen (beta=0.29) and vWF (beta=0.26) in the AF group (R(2)=0.39).	Thioguanine	96-98	von Willebrand factor	Homo sapiens	288-291
26013591-3	2015	THg concentrations in the water column, as well as in sediments and pore waters, were the highest in the northern, most polluted part of the Adriatic Sea as the consequence of Hg mining in Idrija and the heavy industry of northern Italy.	Thioguanine	0-3	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	150-153
26115415-5	2015	We showed that hepatic IFI27, ISG15, and MX1 expression was lower in the IL28B CC 12979860 and TT rs8099917 groups than in the CT-TT rs12979860 and TG-GG rs8099917 groups (P &lt; 0.001).	Thioguanine	148-150	interferon alpha inducible protein 27	Homo sapiens	23-28
26141755-12	2015	CONCLUSIONS: The following mechanisms may have mediated the decrease in plasma lipids levels in mice: a down-regulation of hepatocyte-cholesterol synthesis occurred as a result of decreased HMGCR protein levels and catalytic activity; the levels of LDLR mRNA became elevated, thus suggesting an increase in the uptake of serum LDL, especially by the liver; and TG synthesis became reduced very likely because of a decrease in fatty-acid synthesis.	Thioguanine	361-363	low density lipoprotein receptor	Mus musculus	249-253
25954050-2	2015	ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased activity of these enzymes.	Thioguanine	91-93	angiopoietin-like 3	Mus musculus	124-131
25954050-6	2015	Despite a 61% reduction in VLDL-TG production, VLDL-ApoB-100 production was unchanged in REGN1500-treated animals.	Thioguanine	32-34	CD320 antigen	Mus musculus	27-31
26170905-8	2015	Furthermore, reverse transcription-quantitative polymerase chain reaction (PCR) and immunohistochemistry assays indicated that the expression levels of serine/threonine kinase 11 (Stk11), p53 p21 and activated caspase-3 were elevated significantly in the TG-treated groups.	Thioguanine	255-257	serine/threonine kinase 11	Rattus norvegicus	152-178
26170905-8	2015	Furthermore, reverse transcription-quantitative polymerase chain reaction (PCR) and immunohistochemistry assays indicated that the expression levels of serine/threonine kinase 11 (Stk11), p53 p21 and activated caspase-3 were elevated significantly in the TG-treated groups.	Thioguanine	255-257	serine/threonine kinase 11	Rattus norvegicus	180-185
26170905-8	2015	Furthermore, reverse transcription-quantitative polymerase chain reaction (PCR) and immunohistochemistry assays indicated that the expression levels of serine/threonine kinase 11 (Stk11), p53 p21 and activated caspase-3 were elevated significantly in the TG-treated groups.	Thioguanine	255-257	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	188-191
26170905-8	2015	Furthermore, reverse transcription-quantitative polymerase chain reaction (PCR) and immunohistochemistry assays indicated that the expression levels of serine/threonine kinase 11 (Stk11), p53 p21 and activated caspase-3 were elevated significantly in the TG-treated groups.	Thioguanine	255-257	KRAS proto-oncogene, GTPase	Rattus norvegicus	192-195
26170905-8	2015	Furthermore, reverse transcription-quantitative polymerase chain reaction (PCR) and immunohistochemistry assays indicated that the expression levels of serine/threonine kinase 11 (Stk11), p53 p21 and activated caspase-3 were elevated significantly in the TG-treated groups.	Thioguanine	255-257	caspase 3	Rattus norvegicus	210-219
26170905-9	2015	Serine 15 phosphorylation of p53 was also enhanced significantly in the TG-treated groups.	Thioguanine	72-74	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	29-32
26198961-6	2015	Pearson analysis revealed that regardless of gender, serum cystatin C was positively correlated with SBP, DBP, MAP, BMI, TC, TG, LDL-C, UA and BUN (P&lt;0.05).	Thioguanine	125-127	cystatin C	Homo sapiens	59-69
26115415-5	2015	We showed that hepatic IFI27, ISG15, and MX1 expression was lower in the IL28B CC 12979860 and TT rs8099917 groups than in the CT-TT rs12979860 and TG-GG rs8099917 groups (P &lt; 0.001).	Thioguanine	148-150	MX dynamin like GTPase 1	Homo sapiens	41-44
26115415-5	2015	We showed that hepatic IFI27, ISG15, and MX1 expression was lower in the IL28B CC 12979860 and TT rs8099917 groups than in the CT-TT rs12979860 and TG-GG rs8099917 groups (P &lt; 0.001).	Thioguanine	148-150	interferon lambda 3	Homo sapiens	73-78
26067236-6	2015	We hypothesize that Gde1 expression increases TG production by contributing to the production of glycerol-3-phosphate.	Thioguanine	46-48	glycerophosphodiester phosphodiesterase 1	Mus musculus	20-24
25890254-9	2015	In addition, increased expression level of carbonyl reductase 1 (CBR1) was observed in the hippocampi of 3 x Tg-AD mice.	Thioguanine	109-111	carbonyl reductase 1	Mus musculus	43-63
25890254-9	2015	In addition, increased expression level of carbonyl reductase 1 (CBR1) was observed in the hippocampi of 3 x Tg-AD mice.	Thioguanine	109-111	carbonyl reductase 1	Mus musculus	65-69
25962325-8	2015	Next, a study of miR-696"s role in the deposition of lipids in C2C12 induced by resistin showed that inhibition of miR-696 restored the TG content by up to 80%, which suggests that, in C2C12 cells, resistin at least partially increases the deposition of lipids through miR-696.	Thioguanine	136-138	microRNA 696	Mus musculus	17-24
25756686-2	2015	Besides photoluminescence studies thermal stability for the LZP glass is also evaluated from TG-DTA measurement.	Thioguanine	93-95	oncoprotein induced transcript 3	Homo sapiens	60-63
25962325-8	2015	Next, a study of miR-696"s role in the deposition of lipids in C2C12 induced by resistin showed that inhibition of miR-696 restored the TG content by up to 80%, which suggests that, in C2C12 cells, resistin at least partially increases the deposition of lipids through miR-696.	Thioguanine	136-138	microRNA 696	Mus musculus	115-122
25962325-8	2015	Next, a study of miR-696"s role in the deposition of lipids in C2C12 induced by resistin showed that inhibition of miR-696 restored the TG content by up to 80%, which suggests that, in C2C12 cells, resistin at least partially increases the deposition of lipids through miR-696.	Thioguanine	136-138	microRNA 696	Mus musculus	115-122
26261637-11	2015	CONCLUSIONS: CC and CT+TT and TT and TG+GG genotypes of SMAD3 rs12102171 and rs2289263 polymorphisms together with BMI may be susceptible factors to OA, and interactions there between can possibly confer risk to OA.	Thioguanine	37-39	SMAD family member 3	Homo sapiens	56-61
25917288-0	2015	Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.	Thioguanine	107-120	methylthioadenosine phosphorylase	Homo sapiens	0-33
25917288-0	2015	Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.	Thioguanine	107-120	methylthioadenosine phosphorylase	Homo sapiens	35-39
25917288-1	2015	PURPOSE: To investigate the effectiveness of a combination of 6-thioguanine (6-TG) and pralatrexate (PDX) in methylthioadenosine phosphorylase (MTAP)-deficient T-cell acute lymphoblastic leukemia (T-cell ALL).	Thioguanine	62-75	methylthioadenosine phosphorylase	Homo sapiens	109-142
25917288-1	2015	PURPOSE: To investigate the effectiveness of a combination of 6-thioguanine (6-TG) and pralatrexate (PDX) in methylthioadenosine phosphorylase (MTAP)-deficient T-cell acute lymphoblastic leukemia (T-cell ALL).	Thioguanine	77-81	methylthioadenosine phosphorylase	Homo sapiens	109-142
26149144-14	2015	Tg/ TSH,which means the ratio of sTg variation to TSH variation,may be a useful diagnostic marker for predicting distant metastases in DTC.	Thioguanine	0-2	chromosome 6 open reading frame 15	Homo sapiens	33-36
25639146-11	2015	The proportions of IL28B genotypes were 78%, 21%, and 1% for TT/TG/GG at rs8099917, and 81%, 18%, and 1% for CC/TC/TT at rs12979860, respectively.	Thioguanine	64-66	interferon lambda 3	Homo sapiens	19-24
25639146-13	2015	IL28B genotype was significantly associated with SVR in patients infected by genotype 1 but not genotype 6 HCV, with 80% versus 38% of patients infected by genotype 1 achieved SVR carried TT versus TG/GG at rs8099917, respectively (P=0.003).	Thioguanine	198-200	interferon lambda 3	Homo sapiens	0-5
25000470-6	2015	DISCUSSION: The clinical course of this patient raises the possibility that low-activity TPMT genotypes may influence 6TG toxicity in patients with AML and lead to an increased risk of developing secondary malignant neoplasms.	Thioguanine	118-121	thiopurine S-methyltransferase	Homo sapiens	89-93
25746325-7	2015	Marker rs7844465 (ZHX2) was significantly associated with left carotid IMT in whites (p=0.0005); mean IMT levels for the GG, TG, and TT genotypes were 0.73 (0.71 to 0.74), 0.75 (0.74 to 0.77) and 0.78 (0.75 to 0.81), respectively.	Thioguanine	125-127	zinc fingers and homeoboxes 2	Homo sapiens	18-22
25993652-11	2015	Additionally, serum S100A9 levels displayed a strong correlation with ALT, AST and TBil (r = 0.81, 0.89 and 0.91, P &lt; 0.001) but a weak correlation with FBG, HOMA-IR, TG, and TC (r = -0.41, -0.40, 0.47 and 0.49, P &lt; 0.05).	Thioguanine	170-172	S100 calcium binding protein A9	Rattus norvegicus	20-26
25638157-0	2015	MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation.	Thioguanine	44-57	mutY DNA glycosylase	Homo sapiens	0-5
25945024-10	2015	RESULTS: The meta-analysis showed a significant association between APE1 Asp148Glu polymorphism and GI cancer risk in three genetic models in the overall population (G vs T: OR = 1.18; 95%CI: 1.05-1.32; TG vs TT: OR = 1.28; 95%CI: 1.08-1.52; TG + GG vs TT: OR = 1.32; 95%CI: 1.10-1.57).	Thioguanine	203-205	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	68-72
25945024-10	2015	RESULTS: The meta-analysis showed a significant association between APE1 Asp148Glu polymorphism and GI cancer risk in three genetic models in the overall population (G vs T: OR = 1.18; 95%CI: 1.05-1.32; TG vs TT: OR = 1.28; 95%CI: 1.08-1.52; TG + GG vs TT: OR = 1.32; 95%CI: 1.10-1.57).	Thioguanine	242-244	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	68-72
26064443-5	2015	Lower hepatocyte TG contents were consistent with hepatic Oil-Red-O staining in the CYP1B1 deficiency mice.	Thioguanine	17-19	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	84-90
25638157-5	2015	Surprisingly, Mutyh-null MEFs were more resistant than wild-type MEFs, despite accumulating higher levels of DNA 8-oxo-7,8-dihydroguanine (8-oxoG).Their enhanced 6-TG/UVA resistance reflected the absence of the MUTYH protein and MEFs expressing enzymatically-dead human variants were as sensitive as wild-type cells.	Thioguanine	163-166	mutY DNA glycosylase	Homo sapiens	14-19
25781635-7	2015	Additionally, immunohistochemical analysis showed that COX-2, EP2, Galphas and beta-catenin, key factors involving in PGE2 signal transduction, were positive staining with higher H scores in Non-treatment Tg mice, while the expressions were suppressed significantly by 0.1% canolol (P&lt;0.001).	Thioguanine	205-207	cytochrome c oxidase II, mitochondrial	Mus musculus	55-60
25171455-3	2015	Addition of 6-thioguanine to maintenance therapy of a child with ALL and high TPMT activity increased the TGN/MeMP index in erythrocytes 5.5-fold, mimicking the more favorable thiopurine metabolism seen in patients with low TPMT activity.	Thioguanine	12-25	thiopurine S-methyltransferase	Homo sapiens	78-82
25171455-3	2015	Addition of 6-thioguanine to maintenance therapy of a child with ALL and high TPMT activity increased the TGN/MeMP index in erythrocytes 5.5-fold, mimicking the more favorable thiopurine metabolism seen in patients with low TPMT activity.	Thioguanine	12-25	thiopurine S-methyltransferase	Homo sapiens	224-228
25907932-1	2015	OBJECTIVE: To observe the effect of Tripterygium glycosides (TG) on the expression of hypoxia-inducible factor-1alpha and endothelin-1 in the kidney of diabetic rats and explore the possible mechanism underlying the protective effect of TG against diabetic nephropathy.	Thioguanine	61-63	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	86-117
25907932-1	2015	OBJECTIVE: To observe the effect of Tripterygium glycosides (TG) on the expression of hypoxia-inducible factor-1alpha and endothelin-1 in the kidney of diabetic rats and explore the possible mechanism underlying the protective effect of TG against diabetic nephropathy.	Thioguanine	61-63	endothelin 1	Rattus norvegicus	122-134
25907932-8	2015	Compared with the diabetic model rats, the rats receiving TG and Irbesartan treatment showed decreased levels of Scr, BUN, 24h Upro, MGA and MGV, improved renal histopathology, and reduced expression of HIF-1alpha and ET-1 mRNA and protein in the renal tissue.	Thioguanine	58-60	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	203-213
25907932-8	2015	Compared with the diabetic model rats, the rats receiving TG and Irbesartan treatment showed decreased levels of Scr, BUN, 24h Upro, MGA and MGV, improved renal histopathology, and reduced expression of HIF-1alpha and ET-1 mRNA and protein in the renal tissue.	Thioguanine	58-60	endothelin 1	Rattus norvegicus	218-222
25907932-12	2015	TG can improve kidney damage in diabetic rats and delay the development of diabetic nephropathy by inhibiting the HIF-1alpha and ET-1 expression.	Thioguanine	0-2	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	114-124
25907932-12	2015	TG can improve kidney damage in diabetic rats and delay the development of diabetic nephropathy by inhibiting the HIF-1alpha and ET-1 expression.	Thioguanine	0-2	endothelin 1	Rattus norvegicus	129-133
25722343-1	2015	Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription.	Thioguanine	138-140	lipin 1	Mus musculus	16-33
25781635-7	2015	Additionally, immunohistochemical analysis showed that COX-2, EP2, Galphas and beta-catenin, key factors involving in PGE2 signal transduction, were positive staining with higher H scores in Non-treatment Tg mice, while the expressions were suppressed significantly by 0.1% canolol (P&lt;0.001).	Thioguanine	205-207	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	62-65
25781635-7	2015	Additionally, immunohistochemical analysis showed that COX-2, EP2, Galphas and beta-catenin, key factors involving in PGE2 signal transduction, were positive staining with higher H scores in Non-treatment Tg mice, while the expressions were suppressed significantly by 0.1% canolol (P&lt;0.001).	Thioguanine	205-207	catenin (cadherin associated protein), beta 1	Mus musculus	79-91
24848445-10	2015	For the seminal variables, MaD (-0.45; P &lt; 0.05) and TD (-0.50; P &lt; 0.01) presented a negative correlation with TG.	Thioguanine	118-120	MAX dimerization protein 1	Homo sapiens	27-30
25548259-1	2015	ApoA5 has a critical role in the regulation of plasma TG concentrations.	Thioguanine	54-56	apolipoprotein A-V	Mus musculus	0-5
25548259-5	2015	Furthermore, ApoA5 ASO-treated mice fed a high-fat diet (HFD) exhibited reduced liver and skeletal muscle TG uptake and reduced liver and muscle TG and diacylglycerol (DAG) content.	Thioguanine	106-108	apolipoprotein A-V	Mus musculus	13-18
25548259-5	2015	Furthermore, ApoA5 ASO-treated mice fed a high-fat diet (HFD) exhibited reduced liver and skeletal muscle TG uptake and reduced liver and muscle TG and diacylglycerol (DAG) content.	Thioguanine	145-147	apolipoprotein A-V	Mus musculus	13-18
25616437-1	2015	We previously determined that hamster cholesteryl ester transfer protein (CETP), unlike human CETP, promotes a novel one-way transfer of TG from VLDL to HDL, causing HDL to gain lipid.	Thioguanine	137-139	cholesteryl ester transfer protein	Homo sapiens	74-78
25616437-2	2015	We hypothesize that this nonreciprocal lipid transfer activity arises from the usually high TG/cholesteryl ester (CE) substrate preference of hamster CETP.	Thioguanine	92-94	cholesteryl ester transfer protein	Homo sapiens	150-154
25616437-3	2015	Consistent with this, we report here that ~25% of the total lipid transfer promoted by the human Q199A CETP mutant, which prefers TG as substrate, is nonreciprocal transfer.	Thioguanine	130-132	cholesteryl ester transfer protein	Homo sapiens	103-107
25662052-11	2015	Additionally, the regulation of the Akt/GSK3beta/beta-catenin pathway is severely disturbed in TG at baseline where a significant activation of Akt is found that coincides with the typical phosphorylation of GSK3beta.	Thioguanine	95-97	thymoma viral proto-oncogene 1	Mus musculus	36-39
25662052-11	2015	Additionally, the regulation of the Akt/GSK3beta/beta-catenin pathway is severely disturbed in TG at baseline where a significant activation of Akt is found that coincides with the typical phosphorylation of GSK3beta.	Thioguanine	95-97	glycogen synthase kinase 3 beta	Mus musculus	40-48
25662052-11	2015	Additionally, the regulation of the Akt/GSK3beta/beta-catenin pathway is severely disturbed in TG at baseline where a significant activation of Akt is found that coincides with the typical phosphorylation of GSK3beta.	Thioguanine	95-97	catenin (cadherin associated protein), beta 1	Mus musculus	49-61
25662052-11	2015	Additionally, the regulation of the Akt/GSK3beta/beta-catenin pathway is severely disturbed in TG at baseline where a significant activation of Akt is found that coincides with the typical phosphorylation of GSK3beta.	Thioguanine	95-97	thymoma viral proto-oncogene 1	Mus musculus	144-147
25662052-11	2015	Additionally, the regulation of the Akt/GSK3beta/beta-catenin pathway is severely disturbed in TG at baseline where a significant activation of Akt is found that coincides with the typical phosphorylation of GSK3beta.	Thioguanine	95-97	glycogen synthase kinase 3 beta	Mus musculus	208-216
25568062-4	2015	Compound heterozygous mice lacking Ldlr and Ext1 showed synergy on plasma TG accumulation and postprandial clearance.	Thioguanine	74-76	low density lipoprotein receptor	Mus musculus	35-39
25568062-4	2015	Compound heterozygous mice lacking Ldlr and Ext1 showed synergy on plasma TG accumulation and postprandial clearance.	Thioguanine	74-76	exostosin glycosyltransferase 1	Mus musculus	44-48
25593327-4	2015	These CETP(+) cells had several-fold higher intracellular CETP and accumulated 50% less TG due to a 26% decrease in TG synthesis and 2.5-fold higher TG turnover rate.	Thioguanine	88-90	cholesteryl ester transfer protein	Homo sapiens	6-10
25593327-4	2015	These CETP(+) cells had several-fold higher intracellular CETP and accumulated 50% less TG due to a 26% decrease in TG synthesis and 2.5-fold higher TG turnover rate.	Thioguanine	116-118	cholesteryl ester transfer protein	Homo sapiens	6-10
25593327-4	2015	These CETP(+) cells had several-fold higher intracellular CETP and accumulated 50% less TG due to a 26% decrease in TG synthesis and 2.5-fold higher TG turnover rate.	Thioguanine	116-118	cholesteryl ester transfer protein	Homo sapiens	6-10
25569586-5	2015	Observed under polarized optical microscopy, PEG, PPG, and poloxamer could all significantly improve the crystallization rate of ACM and BFZ, because of the largely reduced Tg of the solid dispersions by these low Tg polymers.	Thioguanine	173-175	serglycin	Homo sapiens	50-53
25405936-5	2015	Transcript levels of matrix metalloprotease (mmp)-3 and MMP-9 were upregulated, and MMP-3 and MMP-9 proteins were increased in the OA-Tg group.	Thioguanine	134-136	matrix metallopeptidase 3	Mus musculus	21-51
25405936-5	2015	Transcript levels of matrix metalloprotease (mmp)-3 and MMP-9 were upregulated, and MMP-3 and MMP-9 proteins were increased in the OA-Tg group.	Thioguanine	134-136	matrix metallopeptidase 3	Mus musculus	84-89
25405936-5	2015	Transcript levels of matrix metalloprotease (mmp)-3 and MMP-9 were upregulated, and MMP-3 and MMP-9 proteins were increased in the OA-Tg group.	Thioguanine	134-136	matrix metallopeptidase 9	Mus musculus	94-99
25463480-7	2015	The in vivo conversion of [14C]acetate to [14C]TG in WAT was also lower in Pemt(-/-) mice.	Thioguanine	47-49	phosphatidylethanolamine N-methyltransferase	Mus musculus	75-79
26237679-2	2015	Here we show that Cdk5-depleted (Cdk5-shRNA) HeLa cells show higher sensitivity to S-phase irradiation, chronic hydroxyurea exposure, and 5-fluorouracil and 6-thioguanine treatment, with hydroxyurea and IR sensitivity also seen in Cdk5-depleted U2OS cells.	Thioguanine	157-170	cyclin dependent kinase 5	Homo sapiens	18-22
24664457-8	2015	Plasma adiponectin concentrations of TG+GG genotype carriers were significantly lower than those of TT genotype in both groups (p &lt; 0.01).	Thioguanine	37-39	adiponectin, C1Q and collagen domain containing	Homo sapiens	7-18
24664457-9	2015	After adjustment for confounding factors, plasma adiponectin level remained significantly lower in pregnant women with TG+GG genotype than those with TT genotype (p &lt; 0.05).	Thioguanine	119-121	adiponectin, C1Q and collagen domain containing	Homo sapiens	49-60
26203767-5	2015	RESULTS: ADIPOQ rs2241766 TG + GG, ADIPOQ rs1501299 GT + TT and CAPN-10 rs3792267 GA + AA were significantly related to CRC risk.	Thioguanine	26-28	adiponectin, C1Q and collagen domain containing	Homo sapiens	9-15
26203767-6	2015	In CART, individuals with high red meat consumption, CAPN-10 rs3792267 GG, ADIPOQ rs1501299 GG and ADIPOQ rs2241766 TG + GG had an OR of 1.821 (95% CI = 1.124-2.951).	Thioguanine	116-118	adiponectin, C1Q and collagen domain containing	Homo sapiens	99-105
25646773-6	2015	Following 8 weeks of high-fat diet, the Tsc1-/-;S6k1-/- mice had lower body weights but higher liver TG levels compared to that of the Tsc1-/- mice.	Thioguanine	101-103	TSC complex subunit 1	Mus musculus	40-44
25646773-6	2015	Following 8 weeks of high-fat diet, the Tsc1-/-;S6k1-/- mice had lower body weights but higher liver TG levels compared to that of the Tsc1-/- mice.	Thioguanine	101-103	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	48-52
26237679-2	2015	Here we show that Cdk5-depleted (Cdk5-shRNA) HeLa cells show higher sensitivity to S-phase irradiation, chronic hydroxyurea exposure, and 5-fluorouracil and 6-thioguanine treatment, with hydroxyurea and IR sensitivity also seen in Cdk5-depleted U2OS cells.	Thioguanine	157-170	cyclin dependent kinase 5	Homo sapiens	33-37
26237679-2	2015	Here we show that Cdk5-depleted (Cdk5-shRNA) HeLa cells show higher sensitivity to S-phase irradiation, chronic hydroxyurea exposure, and 5-fluorouracil and 6-thioguanine treatment, with hydroxyurea and IR sensitivity also seen in Cdk5-depleted U2OS cells.	Thioguanine	157-170	cyclin dependent kinase 5	Homo sapiens	33-37
25973432-3	2015	A significant association was found between aGvHD grades II-IV and SNPs of donor IL10-1082GG, and Fas-670CC + CT and recipient IL18-607 TT + TG genotype.	Thioguanine	141-143	interleukin 18	Homo sapiens	127-131
25312439-9	2015	Furthermore, the basal or angiotensin II-mediated systolic blood pressure remained significantly lower in Trx-Tg mice compared with wild-type or dnTrx-Tg mice, thus directly establishing redox-mediated EDH in blood pressure control.	Thioguanine	110-112	thioredoxin 1	Mus musculus	106-109
24917523-7	2015	CONCLUSION: These data provide the first direct evidence that physiological expression of PNPLA3 148M variant causes NAFLD, and that the accumulation of catalytically inactive PNPLA3 on the surfaces of lipid droplets is associated with the accumulation of TG in the liver.	Thioguanine	256-258	patatin-like phospholipase domain containing 3	Mus musculus	176-182
25873760-5	2015	Three proteins (THIO, TXD17, and GSTM3) with putative functions in cellular oxidative stress responses were altered by 6-TG treatment and another protein PRDX3 was differentially phosphorylated in TPMT kd cells.	Thioguanine	119-123	glutathione S-transferase mu 3	Homo sapiens	33-38
25873760-5	2015	Three proteins (THIO, TXD17, and GSTM3) with putative functions in cellular oxidative stress responses were altered by 6-TG treatment and another protein PRDX3 was differentially phosphorylated in TPMT kd cells.	Thioguanine	119-123	thiopurine S-methyltransferase	Homo sapiens	197-201
25751467-11	2015	The prevalence of UGT1A6 T19G was as follows: TT (45%), TG (38.8%), and GG (16.3%); that of UGT1A6 A541G was: AA (48.8%), AG (38.8%), and GG (12.5%); and that of UGT1A6 A552C was: AA (43.8%), AC (40%), and CC (16.3%).	Thioguanine	56-58	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	18-24
25873760-7	2015	Immunoblot analyses showed treatment altered expression of key antioxidant enzymes (i.e., SOD2 and catalase) in both wt and kd groups, while SOD1 was downregulated by 6-TG treatment and TPMT knockdown.	Thioguanine	167-171	superoxide dismutase 1	Homo sapiens	141-145
26185363-8	2015	RESULTS: Genetic deletion of PI3Kgamma decreased neutrophil numbers in BALF of PI3Kgamma (KO)/betaENaC-Tg mice, and this was associated with reduced emphysematous changes.	Thioguanine	103-105	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	29-38
25320346-9	2014	Finally, preventing the LPS-induced increase in GPR109A/HCA2 resulted in an increase in TG accumulation and the expression of enzymes that catalyze TG synthesis.	Thioguanine	88-90	hydroxycarboxylic acid receptor 2	Homo sapiens	48-55
25743892-6	2015	Unlike other MBD proteins, MBD4 recognizes not only 5mCG/5mCG but also T/G mismatched sites generated by spontaneous deamination of 5-methylcytosine (5mCG/TG).	Thioguanine	155-157	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	27-31
25743892-8	2015	The crystal structures of MBDMBD4 in complex with 5mCG/TG, 5mCG/5mCG or 5mCG/hmCG provide new structural insights into the versatility of base recognition by MBD4.	Thioguanine	55-57	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	29-33
25480665-0	2014	6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells.	Thioguanine	0-13	DNA methyltransferase 1	Canis lupus familiaris	43-48
25480665-2	2014	6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell line, causing downregulation of DNA methyltransferase 1 (DNMT1) through ubiquitin-targeted degradation.	Thioguanine	0-4	DNA methyltransferase 1	Homo sapiens	130-153
25480665-2	2014	6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell line, causing downregulation of DNA methyltransferase 1 (DNMT1) through ubiquitin-targeted degradation.	Thioguanine	0-4	DNA methyltransferase 1	Homo sapiens	155-160
25480665-4	2014	The hypothesis of the present study was that 6-TG and Zeb would cause downregulation of DNMT1 and globally demethylate the genomic DNA of canine lymphoma cells.	Thioguanine	45-49	DNA methyltransferase 1	Canis lupus familiaris	88-93
25341895-9	2014	Injection of recombinant VEGF induced a more pronounced EPC mobilization in Tg, but not in DN-Tg, mice.	Thioguanine	76-78	vascular endothelial growth factor A	Mus musculus	25-29
25536321-4	2015	Tg concentrations were dependent on gender (males&lt;females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine &lt;300 microg/l and the age under 65 years.	Thioguanine	0-2	thyroglobulin	Homo sapiens	68-81
25536321-4	2015	Tg concentrations were dependent on gender (males&lt;females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine &lt;300 microg/l and the age under 65 years.	Thioguanine	0-2	thyroglobulin	Homo sapiens	175-188
25790682-8	2015	RESULTS: Compared with the MCT model group, preventive treatment of TG at the 3 doses could significantly reduce RVSP, RVHI, RVW/BW, and ANF mRNA expression, and decrease Ca2+ concentration in myocardial cells, CaN mRNA and protein expression in the myocardial tissue.	Thioguanine	68-70	natriuretic peptide A	Rattus norvegicus	137-140
25469985-8	2014	The meta-analyses of MS and obesity markers indicated that TG, TC, CRP BMI, TBF%, WC, WHR and Leptin were positively correlated with chemerin, nevertheless, SBP, DBP, LDL-C, HDL-C, ALT and r-GT were not significantly correlated, adiponectin was negatively correlated.	Thioguanine	59-61	retinoic acid receptor responder 2	Homo sapiens	133-141
25469985-8	2014	The meta-analyses of MS and obesity markers indicated that TG, TC, CRP BMI, TBF%, WC, WHR and Leptin were positively correlated with chemerin, nevertheless, SBP, DBP, LDL-C, HDL-C, ALT and r-GT were not significantly correlated, adiponectin was negatively correlated.	Thioguanine	59-61	selenium binding protein 1	Homo sapiens	157-160
25469985-8	2014	The meta-analyses of MS and obesity markers indicated that TG, TC, CRP BMI, TBF%, WC, WHR and Leptin were positively correlated with chemerin, nevertheless, SBP, DBP, LDL-C, HDL-C, ALT and r-GT were not significantly correlated, adiponectin was negatively correlated.	Thioguanine	59-61	D-box binding PAR bZIP transcription factor	Homo sapiens	162-165
25469985-8	2014	The meta-analyses of MS and obesity markers indicated that TG, TC, CRP BMI, TBF%, WC, WHR and Leptin were positively correlated with chemerin, nevertheless, SBP, DBP, LDL-C, HDL-C, ALT and r-GT were not significantly correlated, adiponectin was negatively correlated.	Thioguanine	59-61	component of oligomeric golgi complex 2	Homo sapiens	167-179
25469985-8	2014	The meta-analyses of MS and obesity markers indicated that TG, TC, CRP BMI, TBF%, WC, WHR and Leptin were positively correlated with chemerin, nevertheless, SBP, DBP, LDL-C, HDL-C, ALT and r-GT were not significantly correlated, adiponectin was negatively correlated.	Thioguanine	59-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	229-240
25320346-9	2014	Finally, preventing the LPS-induced increase in GPR109A/HCA2 resulted in an increase in TG accumulation and the expression of enzymes that catalyze TG synthesis.	Thioguanine	88-90	hydroxycarboxylic acid receptor 2	Homo sapiens	56-60
25320346-9	2014	Finally, preventing the LPS-induced increase in GPR109A/HCA2 resulted in an increase in TG accumulation and the expression of enzymes that catalyze TG synthesis.	Thioguanine	148-150	hydroxycarboxylic acid receptor 2	Homo sapiens	48-55
25320346-9	2014	Finally, preventing the LPS-induced increase in GPR109A/HCA2 resulted in an increase in TG accumulation and the expression of enzymes that catalyze TG synthesis.	Thioguanine	148-150	hydroxycarboxylic acid receptor 2	Homo sapiens	56-60
25320346-11	2014	The increase in GPR109A/HCA2 that accompanies macrophage activation inhibits the TG accumulation stimulated by macrophage activation.	Thioguanine	81-83	hydroxycarboxylic acid receptor 2	Homo sapiens	16-23
25320346-11	2014	The increase in GPR109A/HCA2 that accompanies macrophage activation inhibits the TG accumulation stimulated by macrophage activation.	Thioguanine	81-83	hydroxycarboxylic acid receptor 2	Homo sapiens	24-28
25147335-8	2014	Both Ang-2 and Axin-2 mRNA downregulation was recapitulated in the heat-shock-inducible transgenic Tg(hsp70l:dkk1-GFP) zebrafish embryos at 72 hours post fertilization.	Thioguanine	99-101	angiopoietin 2a	Danio rerio	5-10
25394062-10	2014	Patients carrying rs3135506 in the APOA5 gene presented a 9% increase in circulating TG levels (p=0.002) and 10% decrease in HDLc levels (p=0.005).	Thioguanine	85-87	apolipoprotein A5	Homo sapiens	35-40
25193997-5	2014	Inducible, adipocyte-specific deletion of adipose TG lipase (ATGL), the rate-limiting enzyme for lipolysis, demonstrates that TG hydrolysis is required for CL-induced increases in DNL, TG turnover, and mitochondrial electron transport in all depots.	Thioguanine	50-52	patatin like phospholipase domain containing 2	Homo sapiens	61-65
25147335-8	2014	Both Ang-2 and Axin-2 mRNA downregulation was recapitulated in the heat-shock-inducible transgenic Tg(hsp70l:dkk1-GFP) zebrafish embryos at 72 hours post fertilization.	Thioguanine	99-101	axin 2 (conductin, axil)	Danio rerio	15-21
25147335-8	2014	Both Ang-2 and Axin-2 mRNA downregulation was recapitulated in the heat-shock-inducible transgenic Tg(hsp70l:dkk1-GFP) zebrafish embryos at 72 hours post fertilization.	Thioguanine	99-101	dickkopf WNT signaling pathway inhibitor 1b	Danio rerio	109-113
25108897-5	2014	CONCLUSION: Obese T2D patients with high TG:HDL, associated with increased insulin resistance, had considerably increased risk of CHD and CVD.	Thioguanine	41-43	insulin	Homo sapiens	75-82
25538405-3	2014	Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to its inactive form by the enzyme thiopurine methyltransferase (TPMT).	Thioguanine	20-33	thiopurine S-methyltransferase	Homo sapiens	99-127
24826913-7	2014	We also found some significant evidence for the association of the SIGIRR rs7396562 polymorphism with SLE between dominant and recessive model (TG+TT versus GG, P=0.002; TT versus TG+GG, P=0.002).	Thioguanine	144-146	single Ig and TIR domain containing	Homo sapiens	67-73
24826913-7	2014	We also found some significant evidence for the association of the SIGIRR rs7396562 polymorphism with SLE between dominant and recessive model (TG+TT versus GG, P=0.002; TT versus TG+GG, P=0.002).	Thioguanine	180-182	single Ig and TIR domain containing	Homo sapiens	67-73
25538405-3	2014	Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to its inactive form by the enzyme thiopurine methyltransferase (TPMT).	Thioguanine	20-33	thiopurine S-methyltransferase	Homo sapiens	129-133
25262933-5	2014	In stroke group, plasma TG level of who carried Ala54Thr, Thr54Thr of FABP2 is significantly higher than who carring Ala54Ala.	Thioguanine	24-26	fatty acid binding protein 2	Homo sapiens	70-75
25262933-8	2014	CONCLUSIONS: Our study shows that Ala54Thr of FABP2 may be not associated with stroke risk but associated with plasma TG level of stroke patients for Hunan Han population of China.	Thioguanine	118-120	fatty acid binding protein 2	Homo sapiens	46-51
24400682-11	2014	In those with G1H, IL28B polymorphism may predict SVR and guide treatment duration: SVR rates were higher in those with the TT allele treated for more than 48 weeks and those with the TG/GG alleles treated for more than 72 weeks.	Thioguanine	184-186	interferon lambda 3	Homo sapiens	19-24
25255457-5	2014	CaMKKbeta downstream signaling molecules, including adenosine monophosphate-activated protein kinase (AMPK), were also suppressed in alpha-MHC CaMKKbetakd TG mice compared with wild-type (WT) mice.	Thioguanine	155-157	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	0-9
25255457-5	2014	CaMKKbeta downstream signaling molecules, including adenosine monophosphate-activated protein kinase (AMPK), were also suppressed in alpha-MHC CaMKKbetakd TG mice compared with wild-type (WT) mice.	Thioguanine	155-157	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	133-142
24964786-8	2014	Attenuation of decay only in part explains the stimulating effect of fibrinogen on TG, as fibrinogen stimulates prothrombin conversion, regardless of the fibrinogen variant.	Thioguanine	83-85	fibrinogen beta chain	Homo sapiens	69-79
25183481-5	2014	RESULTS: In this study, 21.2% (109 of 512) of patients with metastatic colorectal cancer had the LCS6-variant (TG/GG), which was found twice as frequently in the BRAF-mutated versus the wild-type (WT) group (P=0.03).	Thioguanine	111-113	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	162-166
25335336-15	2014	(3) Compared with the CIA model group, the expression of HIF-1alpha obviously decreased in the TG group and the high dose QR group (P &lt; 0.05), and it showed a decreasing tendency in the low dose QR group with no statistical difference (P &gt; 0.05).	Thioguanine	95-97	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	57-67
25229170-6	2014	RESULTS: There was a significant association between the 1065 T&gt;G of SNAP-25 gene and OROS MPH response, with the good response group defined by the Korean version of ADHD rating scale scores; 33.3% of the subjects with GG genotype showed a good response, whereas 74.7% of those with TT genotype and 72.5% of those with TG genotype showed good responses (P=0.034).	Thioguanine	323-325	synaptosome associated protein 25	Homo sapiens	72-79
25438528-9	2014	Feeding high-fat diets allowed rats to reduce the expression levels of FABP2 mRNA in small intestinal tissue, meanwhile, the rats gained weight and elevate serum TG levels.	Thioguanine	162-164	fatty acid binding protein 2	Rattus norvegicus	71-76
24919401-3	2014	We expressed apoA-I[Lys107del] variant in Escherichia coli, studied its binding to TG-rich emulsion particles, and performed a physicochemical characterization of the protein.	Thioguanine	83-85	apolipoprotein A1	Homo sapiens	13-19
24919401-4	2014	Compared with WT apoA-I, apoA-I[Lys107del] showed enhanced binding to TG-rich particles, lower stability, and greater exposure of hydrophobic surfaces.	Thioguanine	70-72	apolipoprotein A1	Homo sapiens	25-31
24993831-6	2014	Conversely, knockdown of Dec1 expression by an adenovirus expressing Dec1-specific shRNA led to an increase in hepatic TG content in normal mouse livers.	Thioguanine	119-121	basic helix-loop-helix family, member e40	Mus musculus	25-29
24993831-6	2014	Conversely, knockdown of Dec1 expression by an adenovirus expressing Dec1-specific shRNA led to an increase in hepatic TG content in normal mouse livers.	Thioguanine	119-121	basic helix-loop-helix family, member e40	Mus musculus	69-73
24909692-2	2014	Lipoprotein lipase (LPL), a dimeric enzyme, is the main lipase responsible for TG clearance from the blood after food intake.	Thioguanine	79-81	lipoprotein lipase	Homo sapiens	0-18
25135165-7	2014	The greenhouse gas (GHG) emissions during this brief, localized event were considerable: 172 +- 59 Tg CO2-eq (or 31 +- 12 Tg C), representing 5-10% of Indonesia"s mean annual GHG emissions for 2000-2005.	Thioguanine	99-101	complement C2	Homo sapiens	102-105
24968315-5	2014	RESULTS: At baseline, individuals in the highest quartile of DPP4 activity had higher age, WHR, BMI, SBP, fasting insulin, 2h-PG, TG, LDL-C, IL-6, hs-CRP, IGF-II/M6P-R, C-IMT and lower HDL-C compared with individuals in the lowest quartile.	Thioguanine	130-132	dipeptidyl peptidase 4	Homo sapiens	61-65
24899625-3	2014	In this study, we demonstrate that fenofibrate, a PPARalpha agonist and widely used TG-lowering drug, markedly upregulated hepatic VLDLR, which is essential for lowering TG.	Thioguanine	84-86	very low density lipoprotein receptor	Mus musculus	131-136
24899625-3	2014	In this study, we demonstrate that fenofibrate, a PPARalpha agonist and widely used TG-lowering drug, markedly upregulated hepatic VLDLR, which is essential for lowering TG.	Thioguanine	170-172	peroxisome proliferator activated receptor alpha	Mus musculus	50-59
24899625-3	2014	In this study, we demonstrate that fenofibrate, a PPARalpha agonist and widely used TG-lowering drug, markedly upregulated hepatic VLDLR, which is essential for lowering TG.	Thioguanine	170-172	very low density lipoprotein receptor	Mus musculus	131-136
24899625-6	2014	However, overexpression of mouse VLDLR in livers of Vldlr(-/-) mice significantly prevented the increase in serum TG induced by HFD.	Thioguanine	114-116	very low density lipoprotein receptor	Mus musculus	33-38
24899625-6	2014	However, overexpression of mouse VLDLR in livers of Vldlr(-/-) mice significantly prevented the increase in serum TG induced by HFD.	Thioguanine	114-116	very low density lipoprotein receptor	Mus musculus	52-57
24828613-7	2014	These adiponectin-induced changes in hepatic enzymes resulted in a reduction of total TG and FFA and an increase of HNF-4alpha.	Thioguanine	86-88	adiponectin, C1Q and collagen domain containing	Homo sapiens	6-17
25058652-6	2014	Energy measurements showed that the concentration of ATP increased in Tg (smyd1:m3ck) versus wild-type fish at 28  C. After 2 h at 13  C, ATP concentrations were 2.16-fold higher in Tg (smyd1:m3ck) than in wild-type (P&lt;0.05).	Thioguanine	70-72	SET and MYND domain containing 1a	Danio rerio	74-79
25058652-6	2014	Energy measurements showed that the concentration of ATP increased in Tg (smyd1:m3ck) versus wild-type fish at 28  C. After 2 h at 13  C, ATP concentrations were 2.16-fold higher in Tg (smyd1:m3ck) than in wild-type (P&lt;0.05).	Thioguanine	182-184	SET and MYND domain containing 1a	Danio rerio	74-79
25058652-6	2014	Energy measurements showed that the concentration of ATP increased in Tg (smyd1:m3ck) versus wild-type fish at 28  C. After 2 h at 13  C, ATP concentrations were 2.16-fold higher in Tg (smyd1:m3ck) than in wild-type (P&lt;0.05).	Thioguanine	182-184	SET and MYND domain containing 1a	Danio rerio	186-191
25058652-7	2014	At 13  C, the ATP concentration in Tg (smyd1:m3ck) fish and wild-type fish was 63.3% and 20.0%, respectively, of that in wild-type fish at 28  C. Microarray analysis revealed differential expression of 1249 transcripts in Tg (smyd1:m3ck) versus wild-type fish under cold stress.	Thioguanine	35-37	SET and MYND domain containing 1a	Danio rerio	39-44
24909692-2	2014	Lipoprotein lipase (LPL), a dimeric enzyme, is the main lipase responsible for TG clearance from the blood after food intake.	Thioguanine	79-81	lipoprotein lipase	Homo sapiens	20-23
24578003-2	2014	The aim of this study was to clarify the clinical utility of triglyceride in VLDL (VLDL-TG) level, determined using a homogeneous assay kit (Shino-test Corporation, Tokyo, Japan), as an index of insulin resistance.	Thioguanine	88-90	insulin	Homo sapiens	195-202
25075210-9	2014	Furthermore, in the analysis of contraceptives, a significant association was found between the use of contraceptives and the MDM2 variant in the development of high-grade cervical lesions for the TG genotype (p = 0.019; OR = 2.21) when HSIL was compared with control.	Thioguanine	197-199	MDM2 proto-oncogene	Homo sapiens	126-130
24550188-6	2014	Body weight increased from 32.16 +- 2.34 g to 43.03 +- 1.44 g in tg(sm/p22phox) mice (vs. 30.81 +- 0.71 g to 37.89 +- 1.16 g in the WT mice).	Thioguanine	65-67	cytochrome b-245, alpha polypeptide	Mus musculus	71-78
24746514-7	2014	Moreover, CETP*V was found to be associated with hypertriglyceridemia (hTG) independently from APOE*4, age, BMI, alcohol drinking, TC, TG, HDL-c, and LDL-c.	Thioguanine	72-74	cholesteryl ester transfer protein	Homo sapiens	10-14
24480308-11	2014	Compared to NTG, younger TG-ssTnI myocytes demonstrated a significantly bigger contribution of the NCX (16+-2.7% in TG vs 6.9+-0.9% in NTG) and slow mechanisms (3.3+-0.4% in TG vs 1.4+-0.1% in NTG).	Thioguanine	25-27	troponin I, skeletal, slow 1	Mus musculus	28-33
25071254-3	2014	MATERIALS AND METHODS: We analyzed TG-Ab, TPO-Ab in age and gender matched 87 vitiligo patients and 90 healthy controls, the patients of vitiligo who were positive for the presence of TG-Ab and TPO-Ab were followed up to confirm autoimmune thyroid disease subsequently.	Thioguanine	184-186	thyroid peroxidase	Homo sapiens	194-197
24933211-5	2014	NR1 treatment also significantly decreased the levels of CHO, TG, ox-LDL and increased the level of HDL.	Thioguanine	62-64	interleukin 11 receptor, alpha chain 1	Mus musculus	0-3
24766850-10	2014	CONCLUSION: Low concentrations of the direct thrombin inhibitors melagatran and dabigatran enhanced TG and hypercoagulability, possibly via inhibition of the protein C system.	Thioguanine	100-102	coagulation factor II, thrombin	Homo sapiens	45-53
24928612-5	2014	Although not yet tested in man, 6-TG has recently been proposed to treat a wide variety of cancers with a high frequency of homozygous deletion of the gene for methylthioadenosine phosphorylase (MTAP), often codeleted with the adjacent tumor suppressor CDKN2A (p16).	Thioguanine	32-36	methylthioadenosine phosphorylase	Homo sapiens	160-193
24928612-5	2014	Although not yet tested in man, 6-TG has recently been proposed to treat a wide variety of cancers with a high frequency of homozygous deletion of the gene for methylthioadenosine phosphorylase (MTAP), often codeleted with the adjacent tumor suppressor CDKN2A (p16).	Thioguanine	32-36	methylthioadenosine phosphorylase	Homo sapiens	195-199
24928612-5	2014	Although not yet tested in man, 6-TG has recently been proposed to treat a wide variety of cancers with a high frequency of homozygous deletion of the gene for methylthioadenosine phosphorylase (MTAP), often codeleted with the adjacent tumor suppressor CDKN2A (p16).	Thioguanine	32-36	cyclin dependent kinase inhibitor 2A	Homo sapiens	253-259
24928612-5	2014	Although not yet tested in man, 6-TG has recently been proposed to treat a wide variety of cancers with a high frequency of homozygous deletion of the gene for methylthioadenosine phosphorylase (MTAP), often codeleted with the adjacent tumor suppressor CDKN2A (p16).	Thioguanine	32-36	cyclin dependent kinase inhibitor 2A	Homo sapiens	261-264
24480308-11	2014	Compared to NTG, younger TG-ssTnI myocytes demonstrated a significantly bigger contribution of the NCX (16+-2.7% in TG vs 6.9+-0.9% in NTG) and slow mechanisms (3.3+-0.4% in TG vs 1.4+-0.1% in NTG).	Thioguanine	25-27	T cell leukemia, homeobox 2	Mus musculus	99-102
24480308-11	2014	Compared to NTG, younger TG-ssTnI myocytes demonstrated a significantly bigger contribution of the NCX (16+-2.7% in TG vs 6.9+-0.9% in NTG) and slow mechanisms (3.3+-0.4% in TG vs 1.4+-0.1% in NTG).	Thioguanine	25-27	troponin I, skeletal, slow 1	Mus musculus	28-33
24480308-11	2014	Compared to NTG, younger TG-ssTnI myocytes demonstrated a significantly bigger contribution of the NCX (16+-2.7% in TG vs 6.9+-0.9% in NTG) and slow mechanisms (3.3+-0.4% in TG vs 1.4+-0.1% in NTG).	Thioguanine	25-27	T cell leukemia, homeobox 2	Mus musculus	99-102
24480308-12	2014	In older TG-ssTnI myocytes the contributions were not significantly different from NTG (NCX: 4.9+-0.6% in TG vs 5.5+-0.7% in NTG; slow mechanisms: 2.5+-0.3% in TG vs 3.4+-0.3% in NTG).	Thioguanine	9-11	troponin I, skeletal, slow 1	Mus musculus	12-17
24603147-5	2014	The most remarkable change was seen in CTX levels (TG -28.89%, p &lt; 0.001; CG -52.54%, p &lt; 0.001), and there was also a significant difference in the values of CTX between TG and CG (p = 0.012).	Thioguanine	51-53	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	39-42
24918292-6	2014	Using immunohistochemical and Western blotting studies on aortas from TCTP-TG confirmed the elevated expression of RhoA and increase in p-MLC (phosphorylated MLC).	Thioguanine	75-77	tumor protein, translationally-controlled 1	Mus musculus	70-74
24918292-6	2014	Using immunohistochemical and Western blotting studies on aortas from TCTP-TG confirmed the elevated expression of RhoA and increase in p-MLC (phosphorylated MLC).	Thioguanine	75-77	ras homolog family member A	Mus musculus	115-119
24918292-6	2014	Using immunohistochemical and Western blotting studies on aortas from TCTP-TG confirmed the elevated expression of RhoA and increase in p-MLC (phosphorylated MLC).	Thioguanine	75-77	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	138-141
24918292-6	2014	Using immunohistochemical and Western blotting studies on aortas from TCTP-TG confirmed the elevated expression of RhoA and increase in p-MLC (phosphorylated MLC).	Thioguanine	75-77	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	158-161
24566994-8	2014	In contrast, aged AngII-TG male cardiomyocytes exhibited peak shortening equivalent to young TG; yet, myofilament Ca(2+) responsiveness was profoundly reduced with ageing.	Thioguanine	24-26	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	18-23
24603147-5	2014	The most remarkable change was seen in CTX levels (TG -28.89%, p &lt; 0.001; CG -52.54%, p &lt; 0.001), and there was also a significant difference in the values of CTX between TG and CG (p = 0.012).	Thioguanine	177-179	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	39-42
24603147-8	2014	Regarding the ALP level, a significant reduction was detected in TG and CG (-6.84%, p &lt; 0.001 vs. -4.57%, p &lt; 0.001).	Thioguanine	65-67	ATHS	Homo sapiens	14-17
25095382-6	2014	Compared with the model group, both the AC-M group and the AC-H group showed reduction in endothelial injury and significant decrease in the content of TC, TG and LDL-C (P &lt; 0.05 or P &lt; 0.01).	Thioguanine	156-158	acyl-CoA thioesterase 12	Rattus norvegicus	59-63
24752549-0	2014	Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome.	Thioguanine	51-53	peroxisome proliferator activated receptor alpha	Mus musculus	14-23
25174460-4	2014	RESULTS: A-allele of rs780094 in GCKR was associated with increased TC, TG and LDL-C levels (b = 0.06 mmol/L, P = 0.037; b = 0.09 mmol/L, P &lt; 0.001; b = 0.05 mmol/L, P = 0.040) under the additive model adjusted for age, age square and gender.	Thioguanine	72-74	glucokinase regulator	Homo sapiens	33-37
25174460-5	2014	The rs780094 in GCKR was also associated with abnormal levels of TG and LDL-C(OR = 1.60, 95% CI:1.30-1.97, P &lt; 0.001;OR = 1.35, 95%CI:1.02-1.80, P = 0.036).	Thioguanine	65-67	glucokinase regulator	Homo sapiens	16-20
24644242-9	2014	Flow cytometry measurements showed that intracellular nitric oxide (NO) levels were reduced significantly in STZ-WT and hph-1 mice, paralleled by increased superoxide anion levels; both were rescued in STZ-Tg-GCH mice.	Thioguanine	206-208	hyperphenylalaninemia 1	Mus musculus	120-125
24644242-10	2014	Western blot analysis revealed that thrombospondin-1 (TSP-1) was significantly upregulated in the EPCs of STZ-WT mice and hph-1 mice and suppressed in STZ-treated Tg-GCH mice.	Thioguanine	163-165	thrombospondin 1	Mus musculus	36-52
24644242-10	2014	Western blot analysis revealed that thrombospondin-1 (TSP-1) was significantly upregulated in the EPCs of STZ-WT mice and hph-1 mice and suppressed in STZ-treated Tg-GCH mice.	Thioguanine	163-165	thrombospondin 1	Mus musculus	54-59
24673452-6	2014	RESULTS: The results of our meta-analysis suggested that MDM2 T309G polymorphism might be strongly correlated with an increased risk of NSCLC (G allele vs. T allele: OR=1.63, 95% CI: 1.42-1.89, p&lt;0.001; TG+GG vs. TT: OR=1.54, 95% CI: 1.31-1.80, p&lt;0.001; respectively).	Thioguanine	206-208	MDM2 proto-oncogene	Homo sapiens	57-61
25120972-2	2014	CETP is an essential for transfer of cholesterol ester to the liver from peripheral tissues which facilitating its transfer to TG rich VLDL.	Thioguanine	127-129	cholesteryl ester transfer protein	Homo sapiens	0-4
24636347-2	2014	METHODS: HDL mediated cholesterol efflux through the ABCA-1 transporter was measured using BHK cell lines in samples of 71 participants with T2DM in the presence or absence of high triglyceride levels (TG).	Thioguanine	202-204	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	53-59
23962279-3	2014	The thiopurine drugs azathioprine, mercaptopurine and thioguanine are substrates for TPMT; these drugs exhibit well documented myelosuppressive effects on haematopoietic cells and have a track record of idiosyncratic drug reactions.	Thioguanine	54-65	thiopurine S-methyltransferase	Homo sapiens	85-89
24584101-5	2014	Nanomolar activity on BRD4 by BI-2536 and TG-101348, which are clinical PLK1 and JAK2-FLT3 kinase inhibitors, respectively, is particularly noteworthy as these combinations of activities on independent oncogenic pathways exemplify a new strategy for rational single-agent polypharmacological targeting.	Thioguanine	42-44	bromodomain containing 4	Homo sapiens	22-26
24437489-12	2014	These results characterize FoxO6 as an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production.	Thioguanine	112-114	forkhead box O6	Homo sapiens	27-32
24437489-12	2014	These results characterize FoxO6 as an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production.	Thioguanine	112-114	microsomal triglyceride transfer protein	Homo sapiens	80-83
24437489-12	2014	These results characterize FoxO6 as an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production.	Thioguanine	112-114	CD320 antigen	Mus musculus	107-111
24437489-3	2014	We showed that transgenic mice expressing a constitutively active FoxO6 allele developed hypertriglyceridemia, culminating in elevated VLDL-TG levels and impaired postprandial TG clearance.	Thioguanine	140-142	forkhead box O6	Mus musculus	66-71
24437489-3	2014	We showed that transgenic mice expressing a constitutively active FoxO6 allele developed hypertriglyceridemia, culminating in elevated VLDL-TG levels and impaired postprandial TG clearance.	Thioguanine	140-142	CD320 antigen	Mus musculus	135-139
24437489-3	2014	We showed that transgenic mice expressing a constitutively active FoxO6 allele developed hypertriglyceridemia, culminating in elevated VLDL-TG levels and impaired postprandial TG clearance.	Thioguanine	176-178	forkhead box O6	Mus musculus	66-71
24437489-4	2014	This effect resulted in part from increased hepatic VLDL-TG production.	Thioguanine	57-59	CD320 antigen	Mus musculus	52-56
24437489-5	2014	We recapitulated these findings in cultured HepG2 cells and human primary hepatocytes, demonstrating that FoxO6 promoted hepatic VLDL-TG secretion.	Thioguanine	134-136	forkhead box O6	Homo sapiens	106-111
24437489-5	2014	We recapitulated these findings in cultured HepG2 cells and human primary hepatocytes, demonstrating that FoxO6 promoted hepatic VLDL-TG secretion.	Thioguanine	134-136	CD320 antigen	Mus musculus	129-133
24437489-11	2014	FoxO6 inhibition in insulin-resistant liver suppressed hepatic MTP expression and curbed VLDL-TG overproduction, contributing to the amelioration of hypertriglyceridemia in obese and diabetic db/db mice.	Thioguanine	94-96	forkhead box O6	Mus musculus	0-5
24437489-11	2014	FoxO6 inhibition in insulin-resistant liver suppressed hepatic MTP expression and curbed VLDL-TG overproduction, contributing to the amelioration of hypertriglyceridemia in obese and diabetic db/db mice.	Thioguanine	94-96	insulin	Homo sapiens	20-27
24437489-11	2014	FoxO6 inhibition in insulin-resistant liver suppressed hepatic MTP expression and curbed VLDL-TG overproduction, contributing to the amelioration of hypertriglyceridemia in obese and diabetic db/db mice.	Thioguanine	94-96	CD320 antigen	Mus musculus	89-93
24584101-5	2014	Nanomolar activity on BRD4 by BI-2536 and TG-101348, which are clinical PLK1 and JAK2-FLT3 kinase inhibitors, respectively, is particularly noteworthy as these combinations of activities on independent oncogenic pathways exemplify a new strategy for rational single-agent polypharmacological targeting.	Thioguanine	42-44	polo like kinase 1	Homo sapiens	72-76
24584101-5	2014	Nanomolar activity on BRD4 by BI-2536 and TG-101348, which are clinical PLK1 and JAK2-FLT3 kinase inhibitors, respectively, is particularly noteworthy as these combinations of activities on independent oncogenic pathways exemplify a new strategy for rational single-agent polypharmacological targeting.	Thioguanine	42-44	Janus kinase 2	Homo sapiens	81-85
24584101-5	2014	Nanomolar activity on BRD4 by BI-2536 and TG-101348, which are clinical PLK1 and JAK2-FLT3 kinase inhibitors, respectively, is particularly noteworthy as these combinations of activities on independent oncogenic pathways exemplify a new strategy for rational single-agent polypharmacological targeting.	Thioguanine	42-44	fms related receptor tyrosine kinase 3	Homo sapiens	86-90
24529132-8	2014	HD-NS patients showed lower PCSK9, TC and LDL-C levels than control subjects and PCSK9 levels correlated with TC and LDL-C levels (r = 0.35, p = 0.050; r = 0.423, p = 0.0158 respectively) as well as TG levels (r = 0.413, p = 0.0188).	Thioguanine	199-201	proprotein convertase subtilisin/kexin type 9	Homo sapiens	81-86
24632739-7	2014	In vitro functional analysis showed that the two TG dinucleotide repeat variants not only changed subcellular localization of the CELSR1 protein, but also impaired the physical association between CELSR1 and VANGL2, and thus diminished the ability to recruit VANGL2 for cell-cell contact.	Thioguanine	49-51	cadherin EGF LAG seven-pass G-type receptor 1	Homo sapiens	130-136
24632739-7	2014	In vitro functional analysis showed that the two TG dinucleotide repeat variants not only changed subcellular localization of the CELSR1 protein, but also impaired the physical association between CELSR1 and VANGL2, and thus diminished the ability to recruit VANGL2 for cell-cell contact.	Thioguanine	49-51	cadherin EGF LAG seven-pass G-type receptor 1	Homo sapiens	197-203
24632739-7	2014	In vitro functional analysis showed that the two TG dinucleotide repeat variants not only changed subcellular localization of the CELSR1 protein, but also impaired the physical association between CELSR1 and VANGL2, and thus diminished the ability to recruit VANGL2 for cell-cell contact.	Thioguanine	49-51	VANGL planar cell polarity protein 2	Homo sapiens	208-214
24632739-7	2014	In vitro functional analysis showed that the two TG dinucleotide repeat variants not only changed subcellular localization of the CELSR1 protein, but also impaired the physical association between CELSR1 and VANGL2, and thus diminished the ability to recruit VANGL2 for cell-cell contact.	Thioguanine	49-51	VANGL planar cell polarity protein 2	Homo sapiens	259-265
23913269-2	2014	Preliminary results also demonstrate a TG-mediated post-translational modification of phospholipase A2 (PLA2), which catalyzes the release of arachidonic acid from its lipid storage sites.	Thioguanine	39-41	phospholipase A2 group IB	Homo sapiens	86-102
23913269-2	2014	Preliminary results also demonstrate a TG-mediated post-translational modification of phospholipase A2 (PLA2), which catalyzes the release of arachidonic acid from its lipid storage sites.	Thioguanine	39-41	phospholipase A2 group IB	Homo sapiens	104-108
22854916-6	2014	In MetS- patients, ppTG correlated with fasting TG, non-HDL, blood pressure, waist/hip ratio, fasting C-peptide and insulin levels, and HOMA-IR.	Thioguanine	21-23	insulin	Homo sapiens	116-123
24148620-4	2014	METHODS: Hepatocytes were depleted by administration of metronidazole to Tg(fabp10a:CFP-NTR) animals.	Thioguanine	73-75	fatty acid binding protein 10a, liver basic	Danio rerio	76-83
24142546-8	2014	In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95% CI = 0.46-0.95, P = 0.026; TT vs. TG/GG: OR = 0.56, 95% CI = 0.38-0.84, P = 0.005).	Thioguanine	241-243	ATP binding cassette subfamily B member 1	Homo sapiens	103-107
24506864-3	2014	Mice with LRP6(R611C) mutation similarly developed elevated plasma LDL and TG levels and fatty liver.	Thioguanine	75-77	low density lipoprotein receptor-related protein 6	Mus musculus	10-15
24652431-8	2014	The HDLc was associated with decreased insulin resistance in LADA patients (P = 0.041), whereas HbA1c, triacylglycerides (TG) and waist were associated with increased insulin resistance in GAD-negative diabetic patients (P = 3.6x10-12, 1.01x10-5 and 0.004 respectively).	Thioguanine	122-124	insulin	Homo sapiens	167-174
23911087-8	2014	Also, 6 days after induction the TG level in the ADFP siRNA-transfected cells was 21.8% lower than that in negative control-transfected cells.	Thioguanine	33-35	perilipin 2	Bos taurus	49-53
23989113-5	2014	RESULTS: GCKR rs780094 AA genotype was significantly associated with higher TG (p&lt;0.001 vs. GG), lower HDL-C (p=0.021 vs. GG), and lower HbA1c(p=0.023 vs. GG).	Thioguanine	76-78	glucokinase regulator	Homo sapiens	9-13
23989113-8	2014	CONCLUSIONS: GCKR rs780094 was associated with TG, HDL-C, and HbA1c levels, as well as with CIMT in Japanese community-dwelling men, but not women.	Thioguanine	47-49	glucokinase regulator	Homo sapiens	13-17
24401228-9	2014	Interestingly, MetS rats treated with statin secreted greater cholesterol (1.9-fold) and TG (1.5-fold) per apoB48 particle, into mesenteric lymph.	Thioguanine	89-91	apolipoprotein B	Rattus norvegicus	107-113
24431446-8	2014	Quantitative electron microscopy demonstrated that GalNAcT(-/-) and GalNAcT(-/-)-Tg(glial) nerves had significantly increased rates of axon degeneration and reduced myelin volume, whereas GalNAcT(-/-)-Tg(neuronal) and WT appeared normal.	Thioguanine	81-83	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	68-75
24431446-8	2014	Quantitative electron microscopy demonstrated that GalNAcT(-/-) and GalNAcT(-/-)-Tg(glial) nerves had significantly increased rates of axon degeneration and reduced myelin volume, whereas GalNAcT(-/-)-Tg(neuronal) and WT appeared normal.	Thioguanine	81-83	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	68-75
24431446-9	2014	The increased invasion of the paranode with juxtaparanodal Kv1.1, characteristically seen in GalNAcT(-/-) and attributed to a breakdown of the axo-glial junction, was normalized in GalNAcT(-/-)-Tg(neuronal) but remained present in GalNAcT(-/-)-Tg(glial) mice.	Thioguanine	194-196	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	59-64
24431446-9	2014	The increased invasion of the paranode with juxtaparanodal Kv1.1, characteristically seen in GalNAcT(-/-) and attributed to a breakdown of the axo-glial junction, was normalized in GalNAcT(-/-)-Tg(neuronal) but remained present in GalNAcT(-/-)-Tg(glial) mice.	Thioguanine	194-196	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	181-188
24431446-9	2014	The increased invasion of the paranode with juxtaparanodal Kv1.1, characteristically seen in GalNAcT(-/-) and attributed to a breakdown of the axo-glial junction, was normalized in GalNAcT(-/-)-Tg(neuronal) but remained present in GalNAcT(-/-)-Tg(glial) mice.	Thioguanine	194-196	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	181-188
24431446-9	2014	The increased invasion of the paranode with juxtaparanodal Kv1.1, characteristically seen in GalNAcT(-/-) and attributed to a breakdown of the axo-glial junction, was normalized in GalNAcT(-/-)-Tg(neuronal) but remained present in GalNAcT(-/-)-Tg(glial) mice.	Thioguanine	244-246	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	59-64
24431446-9	2014	The increased invasion of the paranode with juxtaparanodal Kv1.1, characteristically seen in GalNAcT(-/-) and attributed to a breakdown of the axo-glial junction, was normalized in GalNAcT(-/-)-Tg(neuronal) but remained present in GalNAcT(-/-)-Tg(glial) mice.	Thioguanine	244-246	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	181-188
24431446-9	2014	The increased invasion of the paranode with juxtaparanodal Kv1.1, characteristically seen in GalNAcT(-/-) and attributed to a breakdown of the axo-glial junction, was normalized in GalNAcT(-/-)-Tg(neuronal) but remained present in GalNAcT(-/-)-Tg(glial) mice.	Thioguanine	244-246	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	181-188
24176890-11	2014	Taken together, these results suggest that the SLN-based THG system can be used as a potential vehicle for ocular application.	Thioguanine	57-60	sarcolipin	Homo sapiens	47-50
24205968-6	2014	The presence of the Asn291Ser polymorphism influenced the higher TG and LDL-C levels and the lower HDL-C levels in mild preeclampsia and the higher TG and LDL-C levels in severe preeclampsia.	Thioguanine	65-67	component of oligomeric golgi complex 2	Homo sapiens	155-160
24205968-6	2014	The presence of the Asn291Ser polymorphism influenced the higher TG and LDL-C levels and the lower HDL-C levels in mild preeclampsia and the higher TG and LDL-C levels in severe preeclampsia.	Thioguanine	148-150	component of oligomeric golgi complex 2	Homo sapiens	72-77
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	57-59	arginase, liver	Mus musculus	36-40
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	57-59	TEK receptor tyrosine kinase	Mus musculus	48-52
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	57-59	nitric oxide synthase 2, inducible	Mus musculus	94-98
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	57-59	nitric oxide synthase 2, inducible	Mus musculus	134-138
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	57-59	arginase, liver	Mus musculus	189-193
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	210-212	arginase, liver	Mus musculus	36-40
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	210-212	nitric oxide synthase 2, inducible	Mus musculus	94-98
24465919-8	2014	A strongly reduced NO production in Arg1(fl/fl)/Tie2-Cre(tg/-) mice following infusion of the NOS2 inhibitor 1400W further implicated NOS2 in the enhanced capacity to produce NO production Arg1(fl/fl)/Tie2-Cre(tg/-) mice.	Thioguanine	210-212	nitric oxide synthase 2, inducible	Mus musculus	134-138
23719772-9	2014	However, in DGKalpha-TG mice, activation of PKCepsilon, ERK1/2, and p70S6K was attenuated compared to WT mice.	Thioguanine	21-23	diacylglycerol kinase, alpha	Mus musculus	12-20
24900988-7	2014	Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP-/- mouse primary hepatocytes (MPH), and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme.	Thioguanine	72-74	fibroblast growth factor 21	Mus musculus	63-68
24900988-7	2014	Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP-/- mouse primary hepatocytes (MPH), and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme.	Thioguanine	72-74	DNA-damage inducible transcript 3	Mus musculus	15-19
24900988-7	2014	Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP-/- mouse primary hepatocytes (MPH), and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme.	Thioguanine	72-74	DNA-damage inducible transcript 3	Mus musculus	96-100
23677722-6	2014	The frequency of the following genotypes was significantly lower in patients compared to controls: IL-4 (-1098) TG (p = 0.035), IL-4 (-590) TC (p &lt; 0.0001), and IL-4 (-33) TC (p &lt; 0.0001).	Thioguanine	112-114	interleukin 4	Homo sapiens	99-103
23719772-9	2014	However, in DGKalpha-TG mice, activation of PKCepsilon, ERK1/2, and p70S6K was attenuated compared to WT mice.	Thioguanine	21-23	protein kinase C, epsilon	Mus musculus	44-54
23719772-9	2014	However, in DGKalpha-TG mice, activation of PKCepsilon, ERK1/2, and p70S6K was attenuated compared to WT mice.	Thioguanine	21-23	mitogen-activated protein kinase 3	Mus musculus	56-62
23719772-9	2014	However, in DGKalpha-TG mice, activation of PKCepsilon, ERK1/2, and p70S6K was attenuated compared to WT mice.	Thioguanine	21-23	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	68-74
24672803-9	2014	Postoperatively, ghrelin was significantly increased in MGBP and RYGB groups but decreased in TG group.	Thioguanine	94-96	ghrelin and obestatin prepropeptide	Rattus norvegicus	17-24
23591768-6	2014	Detectable levels of IFN-lambdas were inducible even in a small amount of PBMC, and IFN-lambda3 was more robustly up-regulated by R-837 in PBMC of CHC patients with favorable genotype for the response to Peg-IFN/RBV (TT in rs8099917) than those with TG/GG.	Thioguanine	250-252	interferon lambda 3	Homo sapiens	84-95
24672803-11	2014	Ghrelin/obestatin in TG group decreased significantly.	Thioguanine	21-23	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
23993507-1	2013	A novel Pb(II) ion imprinted polymer coated on magnetic mesoporous silica was synthesised and characterised by scanning electron microscopy (SEM), thermal gravimetric/differential thermal analysis (TG/DTA), elemental analysis (CHN) and low angle X-ray powder diffraction (XRD).	Thioguanine	198-200	submaxillary gland androgen regulated protein 3B	Homo sapiens	8-14
24623236-3	2014	The assay is based on a mitogen- and growth factor-dependent clonal expansion of peripheral T-lymphocytes in which the 6-thioguanine-resistant HPRT mutants can be selected, enumerated, and collected for molecular analysis of the mutational nature.	Thioguanine	119-132	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	143-147
24474658-11	2014	Our findings suggest that CRP genetic polymorphisms independently had positive association with the risk of HDL, LDL and TG elevating and further replication in other large population and biological function research would be warranted.	Thioguanine	121-123	C-reactive protein	Homo sapiens	26-29
24239761-3	2014	Cu(II), Co(II) and Ni(II) complexes of the prepared ligands have been synthesized and characterized by various spectroscopic techniques like IR, UV-Visible as well as magnetic and thermal (TG and DTA) measurements.	Thioguanine	189-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
24133194-8	2013	In conclusion, the present work suggests that DHA can inhibit the secretion of TG from intestinal epithelial cells via PPARalpha activation, which attenuates postprandial hyperlipidemia.	Thioguanine	79-81	peroxisome proliferator activated receptor alpha	Mus musculus	119-128
24427334-12	2014	The proliferation index of uterus, evaluated by histomorphological changes and the expression of Ki-67, was significantly suppressed in TG treated animals.	Thioguanine	136-138	antigen identified by monoclonal antibody Ki 67	Mus musculus	97-102
24349246-7	2013	Significant differences were observed comparing MDM2 genotype frequencies at position 309 of intron 1 between cases (GG: 21.6%, TG: 54.5%, TT: 23.8%) and controls (GG: 7.3%, TG: 43.9%, TT: 48.7%).	Thioguanine	174-176	MDM2 proto-oncogene	Homo sapiens	48-52
24096753-6	2013	RESULTS: Cumulative vitamin B12 deficiency rates were 100% for TG and 15.7% for DG 4 years after surgery (P &lt; 0.001).	Thioguanine	63-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	28-31
24096753-8	2013	Preoperative vitamin B12 level was the only risk factor for vitamin B12 deficiency after TG, whereas both preoperative vitamin B12 level and age were risk factors after DG.	Thioguanine	89-91	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	21-24
24096753-9	2013	There was positive linear correlation between preoperative vitamin B12 levels and the time to vitamin B12 deficiency after either TG (P &lt; 0.001) or DG (P = 0.017).	Thioguanine	130-132	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	67-70
24096753-9	2013	There was positive linear correlation between preoperative vitamin B12 levels and the time to vitamin B12 deficiency after either TG (P &lt; 0.001) or DG (P = 0.017).	Thioguanine	130-132	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	102-105
24062231-4	2013	RESULTS: Genotypes in XRCC4 were associated with BC risk, with ORs of 1.67 (95 % CI 1.01-2.76) for the combined GA/AA of rs1805377 and 1.69 (95 % CI 1.03-2.77) for rs1056503 TG/GG; these associations were no longer statistically significant in multivariable conditional logistic regression models.	Thioguanine	174-176	X-ray repair cross complementing 4	Homo sapiens	22-27
24358199-8	2013	Meanwhile, Bscl2(-/-) adipocytes from EWAT had increased gene expression in lipid uptake and TG synthesis but not de novo lipogenesis.	Thioguanine	93-95	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	Mus musculus	11-16
24097412-3	2013	We found that the relationship between total cholesterol (TC) and triglycerides (ln TG) varies by APOE isoform genotype in African-American (AA) and European-American (EA) populations.	Thioguanine	84-86	apolipoprotein E	Homo sapiens	98-102
24113235-1	2013	Thiopurine efficacy is partly reflected by the genetic polymorphism of the thiopurine methyltransferase (TPMT) enzyme, which is responsible for variation in the metabolism, toxicity and therapeutic efficacy of the thiopurines azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	274-287	thiopurine S-methyltransferase	Homo sapiens	75-103
25566426-4	2013	Treadmill exercise ameliorated cognitive function in water maze test and significantly increased the level of Bcl-2/Bax ratio and HSP-70 in Tg-exe group compared to Tg-con group; on the other hand, it significantly decreased the expression of caspase-3 and COX-2 in Tg-exe group compared to Tg-con group.	Thioguanine	140-142	B cell leukemia/lymphoma 2	Mus musculus	110-115
25566426-4	2013	Treadmill exercise ameliorated cognitive function in water maze test and significantly increased the level of Bcl-2/Bax ratio and HSP-70 in Tg-exe group compared to Tg-con group; on the other hand, it significantly decreased the expression of caspase-3 and COX-2 in Tg-exe group compared to Tg-con group.	Thioguanine	140-142	BCL2-associated X protein	Mus musculus	116-119
25566426-4	2013	Treadmill exercise ameliorated cognitive function in water maze test and significantly increased the level of Bcl-2/Bax ratio and HSP-70 in Tg-exe group compared to Tg-con group; on the other hand, it significantly decreased the expression of caspase-3 and COX-2 in Tg-exe group compared to Tg-con group.	Thioguanine	140-142	heat shock protein 1B	Mus musculus	130-136
25566426-4	2013	Treadmill exercise ameliorated cognitive function in water maze test and significantly increased the level of Bcl-2/Bax ratio and HSP-70 in Tg-exe group compared to Tg-con group; on the other hand, it significantly decreased the expression of caspase-3 and COX-2 in Tg-exe group compared to Tg-con group.	Thioguanine	140-142	caspase 3	Mus musculus	243-252
25566426-4	2013	Treadmill exercise ameliorated cognitive function in water maze test and significantly increased the level of Bcl-2/Bax ratio and HSP-70 in Tg-exe group compared to Tg-con group; on the other hand, it significantly decreased the expression of caspase-3 and COX-2 in Tg-exe group compared to Tg-con group.	Thioguanine	140-142	cytochrome c oxidase II, mitochondrial	Mus musculus	257-262
25566426-5	2013	In addition, treadmill exercise significantly increased the expression of BDNF and PI3K/Akt in Tg-exe group compared to Tg-con group.	Thioguanine	95-97	brain derived neurotrophic factor	Mus musculus	74-78
25566426-5	2013	In addition, treadmill exercise significantly increased the expression of BDNF and PI3K/Akt in Tg-exe group compared to Tg-con group.	Thioguanine	95-97	thymoma viral proto-oncogene 1	Mus musculus	88-91
23585120-6	2013	Thrombin further induced CaMKII phosphorylation and PKCalpha translocation, which were inhibited by U73122, D609, KN62, TG, or BAPTA/AM.	Thioguanine	120-122	coagulation factor II	Rattus norvegicus	0-8
23585120-6	2013	Thrombin further induced CaMKII phosphorylation and PKCalpha translocation, which were inhibited by U73122, D609, KN62, TG, or BAPTA/AM.	Thioguanine	120-122	protein kinase C, alpha	Rattus norvegicus	52-60
24113235-1	2013	Thiopurine efficacy is partly reflected by the genetic polymorphism of the thiopurine methyltransferase (TPMT) enzyme, which is responsible for variation in the metabolism, toxicity and therapeutic efficacy of the thiopurines azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	274-287	thiopurine S-methyltransferase	Homo sapiens	105-109
24113235-1	2013	Thiopurine efficacy is partly reflected by the genetic polymorphism of the thiopurine methyltransferase (TPMT) enzyme, which is responsible for variation in the metabolism, toxicity and therapeutic efficacy of the thiopurines azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	289-293	thiopurine S-methyltransferase	Homo sapiens	75-103
24113235-1	2013	Thiopurine efficacy is partly reflected by the genetic polymorphism of the thiopurine methyltransferase (TPMT) enzyme, which is responsible for variation in the metabolism, toxicity and therapeutic efficacy of the thiopurines azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	289-293	thiopurine S-methyltransferase	Homo sapiens	105-109
23994331-8	2013	High SAA (P=0.0067) and TG (P=0.0123) were significant predictors of apoA-I/HDL-C ratio.	Thioguanine	24-26	apolipoprotein A1	Homo sapiens	69-75
24172093-12	2013	CONCLUSIONS: We found a significant association between endometrial cancer risk and XRCC1 polymorphisms and haplotype TG in postmenopausal Japanese women.	Thioguanine	118-120	X-ray repair cross complementing 1	Homo sapiens	84-89
24056699-3	2013	Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes.	Thioguanine	43-45	pro-melanin-concentrating hormone	Mus musculus	46-50
24056699-3	2013	Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes.	Thioguanine	43-45	pro-melanin concentrating hormone	Homo sapiens	96-99
24507231-12	2013	The multi factor analysis showed that high TC, high TG and abnormal TG were also associated with the increased risk of SDH (OR (95%CI):1.38 (1.14-1.67), 1.43(1.18-1.75), 1.73 (1.43-2.10) respectively).	Thioguanine	52-54	serine dehydratase	Homo sapiens	119-122
25478513-10	2013	RESULTS: A non-significant (P &lt; 0.4, P &lt; 0.79, respectively) increase in ABCA1 and PPAR alpha genes expression was accompanied by a significant (P &lt; 0.01, P &lt; 0.04, P &lt; 0.04, respectively) reduction in TC, TG, and VLDL-C levels in Crataegus-Pentaegyna groups.	Thioguanine	221-223	ATP binding cassette subfamily A member 1	Rattus norvegicus	79-84
25478513-10	2013	RESULTS: A non-significant (P &lt; 0.4, P &lt; 0.79, respectively) increase in ABCA1 and PPAR alpha genes expression was accompanied by a significant (P &lt; 0.01, P &lt; 0.04, P &lt; 0.04, respectively) reduction in TC, TG, and VLDL-C levels in Crataegus-Pentaegyna groups.	Thioguanine	221-223	peroxisome proliferator activated receptor alpha	Rattus norvegicus	89-99
24507231-12	2013	The multi factor analysis showed that high TC, high TG and abnormal TG were also associated with the increased risk of SDH (OR (95%CI):1.38 (1.14-1.67), 1.43(1.18-1.75), 1.73 (1.43-2.10) respectively).	Thioguanine	68-70	serine dehydratase	Homo sapiens	119-122
24194719-8	2013	Increased ecSOD colocalization to myocardial mitochondria in ecSOD Tg hearts limited MPT in response to Ca(2+) challenge.	Thioguanine	67-69	superoxide dismutase 3, extracellular	Mus musculus	10-15
24194719-8	2013	Increased ecSOD colocalization to myocardial mitochondria in ecSOD Tg hearts limited MPT in response to Ca(2+) challenge.	Thioguanine	67-69	superoxide dismutase 3, extracellular	Mus musculus	61-66
23703028-11	2013	AEBSF pretreatment abolished Tg-induced SREBP-1c cleavage.	Thioguanine	29-31	sterol regulatory element binding transcription factor 1	Homo sapiens	40-48
24227948-2	2013	After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in the liver of HBx Tg mice.	Thioguanine	154-156	retinol binding protein 1, cellular	Mus musculus	80-86
24227948-2	2013	After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in the liver of HBx Tg mice.	Thioguanine	154-156	X protein	Hepatitis B virus	133-136
24227948-2	2013	After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in the liver of HBx Tg mice.	Thioguanine	154-156	X protein	Hepatitis B virus	150-153
24227948-2	2013	After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in the liver of HBx Tg mice.	Thioguanine	154-156	X protein	Hepatitis B virus	150-153
24072166-10	2013	TG in patients with haemophilia A correlated with levels of FVIII activity, but there was no significant relationship between PG and FVIII:C, confirming that the abnormal haemostasis in haemophilia A results in a severe imbalance between coagulation and fibrinolysis.	Thioguanine	0-2	coagulation factor VIII	Homo sapiens	60-65
23665283-10	2013	Higher serum irisin levels were associated with preferable TG levels.	Thioguanine	59-61	fibronectin type III domain containing 5	Homo sapiens	13-19
23786914-11	2013	Significantly lower miR-137 expression levels were observed in the homozygous TT subjects compared to TG and GG subjects in the control group (30% decrease, p-value = 0.03).	Thioguanine	102-104	microRNA 137	Homo sapiens	20-27
24147097-7	2013	Moreover, we found that IL28B rs8099917 G variants (TG+GG) interact with HCV genotype 1(G1) to result in higher risk of NVR (P=0.009), and that they are also associated with HBV DNA reactivation (TG+GG vs. TT, P=0.005).	Thioguanine	52-54	interferon lambda 3	Homo sapiens	24-29
24083090-10	2013	Thus, our study underscores the utility of genetically labeled BMSCs isolated from hPLAP-tg donors for long-term tracking of the fate of transplanted MSCs in regenerative therapies.	Thioguanine	89-91	alkaline phosphatase, placental	Homo sapiens	83-88
24422407-8	2013	RESULT: Low, middle and high doses of TG and L-arg preventive administration could significantly reduce RVSP, RVHI, RVW/BW and ANF mRNA expressions (P &lt; 0.	Thioguanine	38-40	natriuretic peptide A	Rattus norvegicus	127-130
23399889-7	2013	The number of choline-acetyltransferase-immunoreactive neurons in the nucleus ambiguus was significantly decreased in the tg group, whereas the levels of arginine-vasopressin neurons in the suprachiasmatic and paraventricular nucleus were not affected.	Thioguanine	122-124	choline acetyltransferase	Mus musculus	14-39
22727960-7	2013	In addition, EAT expression of LPL, acyl coA dehydrogenase-short, -medium and -long chain genes associated negatively with circulating TG levels (P &lt;= 0.05).	Thioguanine	135-137	lipoprotein lipase	Homo sapiens	31-34
23703028-13	2013	Pharmacological ERS induced by Tg leads to lipid accumulation through upregulation of SREBP-1c in L02 and HepG2 cells.	Thioguanine	31-33	sterol regulatory element binding transcription factor 1	Homo sapiens	86-94
24205718-2	2013	Increased production of VLDL from the liver and the decreased catabolism of VLDL-TG in the vessel, which are also the main metabolic features of insulin resistance, have been proposed to be the causes of endogenous hypertriglyceridemia.	Thioguanine	81-83	insulin	Homo sapiens	145-152
24205719-1	2013	Familial type III hyperlipoproteinemia(HLP) is characterized by increased plasma triglyceride(TG) and plasma remnant lipoproteins(chyromicron remnants and VLDL remnants i.e. IDL).	Thioguanine	94-96	HLP	Homo sapiens	0-43
24205719-5	2013	High plasma RLP-C levels above 30 mg/dL and high plasma RLP-C/plasma TG ratio above 0.1 are very useful for diagnosis of type III HLP.	Thioguanine	69-71	HLP	Homo sapiens	130-133
23703524-6	2013	Spontaneous Ca(2+) transients in myocytes of NCX1.3(tg/tg) were larger and frequently resulted in propagating events and global elevations in cytosolic Ca(2+) concentration.	Thioguanine	52-54	T cell leukemia, homeobox 2	Mus musculus	45-49
23822884-9	2013	Globally, we estimate that AOM could consume a large proportion of CH4 produced annually (1.6-49 Tg) and thereby constrain emissions and greenhouse gas forcing.	Thioguanine	97-99	collagen type II alpha 1 chain	Homo sapiens	27-30
23608100-8	2013	Our results showed that N-acetylaspartate (NAA) levels increased and myo-inositol levels decreased in Tg-BDNF mice compared with Tg-PBS mice.	Thioguanine	102-104	brain derived neurotrophic factor	Mus musculus	105-109
23608100-10	2013	These changes correlated with increased immunoreactivity of TrkB, reduced compact Abeta peptide and FJB+ neurons in Tg-BDNF mice compared to Tg-PBS mice.	Thioguanine	116-118	brain derived neurotrophic factor	Mus musculus	119-123
23715864-7	2013	BMP-2 caused a further significant increase in mineralized colonies in Tg(LMW) COBs compared with Tg(Vector) COBs but did not increase alkaline phosphatase-positive colonies in Tg(HMW) COBs.	Thioguanine	71-73	bone morphogenetic protein 2	Mus musculus	0-5
23178293-10	2013	The lower autoantibody production in APRIL-Tg mice during CIA appears to be crucial, as arthritis induced by administration of anti-collagen antibodies developed similar in APRIL-Tg and control mice, thus demonstrating that the downstream effector pathways induced by anti-collagen antibodies remain intact in APRIL-Tg mice.	Thioguanine	43-45	tumor necrosis factor (ligand) superfamily, member 13	Mus musculus	37-42
23715864-12	2013	Interestingly, although basal expression of FGF receptor 2 was similar in COBs from all genotypes, BMP-2 treatment caused a sustained increase in Tg(LMW) COBs but decreased FGF receptor 2 in Tg(Vector) COBs and Tg(HMW) COBs.	Thioguanine	146-148	bone morphogenetic protein 2	Mus musculus	99-104
23837919-7	2013	The elevation of hepatic TG levels after HCTZ treatment was additionally accompanied by a reduction in insulin sensitivity:  SI HCTZ = -1.14.	Thioguanine	25-27	insulin	Homo sapiens	103-110
23811272-0	2013	Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells.	Thioguanine	99-112	thiopurine S-methyltransferase	Homo sapiens	21-49
23811272-2	2013	Thiopurine methyltransferase (TPMT) is one of the most important enzymes in this process metabolizing both 6-MP and 6-TG to different methylated metabolites including methylthioinosine monophosphate (meTIMP) and methylthioguanosine monophosphate (meTGMP), respectively, with different suggested pharmacological and cytotoxic properties.	Thioguanine	116-120	thiopurine S-methyltransferase	Homo sapiens	0-28
23811272-2	2013	Thiopurine methyltransferase (TPMT) is one of the most important enzymes in this process metabolizing both 6-MP and 6-TG to different methylated metabolites including methylthioinosine monophosphate (meTIMP) and methylthioguanosine monophosphate (meTGMP), respectively, with different suggested pharmacological and cytotoxic properties.	Thioguanine	116-120	thiopurine S-methyltransferase	Homo sapiens	30-34
23811272-4	2013	In order to investigate the role of TPMT in metabolism and thus, cytotoxic effects of 6-MP and 6-TG, we knocked down the expression of the gene encoding the TPMT enzyme using specifically designed small interference RNA (siRNA) in human MOLT4 leukemia cells.	Thioguanine	95-99	thiopurine S-methyltransferase	Homo sapiens	157-161
23811272-7	2013	The results showed a 34% increase in sensitivity of MOLT4 cells to 1muM 6-TG after treatment with TPMT-targeting siRNA, as compared to cells transfected with non-targeting siRNA, while the sensitivity of the cells toward 6-MP was not affected significantly by down-regulation of the TPMT gene.	Thioguanine	72-76	thiopurine S-methyltransferase	Homo sapiens	98-102
23811272-7	2013	The results showed a 34% increase in sensitivity of MOLT4 cells to 1muM 6-TG after treatment with TPMT-targeting siRNA, as compared to cells transfected with non-targeting siRNA, while the sensitivity of the cells toward 6-MP was not affected significantly by down-regulation of the TPMT gene.	Thioguanine	72-76	thiopurine S-methyltransferase	Homo sapiens	283-287
23811272-8	2013	This differential contribution of the enzyme TPMT to the cytotoxicity of the two thiopurines is probably due to its role in formation of the meTIMP, the cytotoxic methylated metabolite of 6-MP, while in case of 6-TG methylation by TPMT substantially deactivates the drug.	Thioguanine	211-215	thiopurine S-methyltransferase	Homo sapiens	45-49
23811272-8	2013	This differential contribution of the enzyme TPMT to the cytotoxicity of the two thiopurines is probably due to its role in formation of the meTIMP, the cytotoxic methylated metabolite of 6-MP, while in case of 6-TG methylation by TPMT substantially deactivates the drug.	Thioguanine	211-215	thiopurine S-methyltransferase	Homo sapiens	231-235
23866694-7	2013	RESULTS: Comparison of data between V1 and V2 after SY consumption showed a significant decrease in triglyceridemia (23%), VLDL TG (31%) and tendency to a decrease of VLDL cholesterol (p = 0.066) at fasting state.	Thioguanine	128-130	immunoglobulin kappa variable 1-5	Homo sapiens	36-45
23735640-10	2013	CONCLUSION: The results of our study demonstrated that rs1059611 was associated with HDL-C and TG concentrations in Chinese Han population and might have a functional effect on the transcription of LPL by differential binding of transcription factors.	Thioguanine	95-97	lipoprotein lipase	Homo sapiens	198-201
23817628-1	2013	Tissue transglutaminase (TGC, TG2, 80 kDa) is inactive in cross-linking reactions and is converted in vitro and in vivo to the TG (55 kDa) active isoform (Fraij in J Cell Biochem 112:2469-2489, 2011).	Thioguanine	25-27	transglutaminase 2	Homo sapiens	0-23
23970116-13	2013	The immunohistochemical analysis indicated that, at both time points, the expression of cyclooxygenase-2 was upregulated in the TG compared to the CG.	Thioguanine	128-130	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	88-104
23411637-10	2013	The concurrence of high glucose/high TG or high glucose/low HDL-c increased TC/HDL-c and HOMA-IR, but decreased, oxLDL, oxLDL/LDL-c and QUICKI with respect to that of low glucose/low TG or glucose/high HDL-c.	Thioguanine	37-39	component of oligomeric golgi complex 2	Homo sapiens	126-131
23624761-1	2013	This study compares the ability of an elevated triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, using sex-specific cut-points, to identify insulin-resistant individuals within a population without known cardiac disease or diabetes with that obtained using the diagnostic criteria of the metabolic syndrome (MetS).	Thioguanine	98-100	insulin	Homo sapiens	158-165
23735588-8	2013	In these subjects, annexin V was less effective in inhibiting both basal and ADP-induced TG.	Thioguanine	89-91	annexin A5	Homo sapiens	19-28
24027984-7	2013	Sea to air CH4 fluxes were (2.85 +/- 5.11) micromol x (m2 x d)(-1) (5.18 +/- 9.99) micromol x (m2 x d)(-1) respectively, calculated using the Liss and Merlivat (LM86), the Wanninkhof (W92) relationships and in situ wind speeds, and estimated emission rates of methane from the East China Sea and the Yellow Sea range from 7.05 x 10(-2) - 12.0 x 10(-2) Tg x a(-1) and 1.17 x 10(-2) - 2.20 x 10(-2) Tg x a(-1), respectively.	Thioguanine	352-354	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
24027984-7	2013	Sea to air CH4 fluxes were (2.85 +/- 5.11) micromol x (m2 x d)(-1) (5.18 +/- 9.99) micromol x (m2 x d)(-1) respectively, calculated using the Liss and Merlivat (LM86), the Wanninkhof (W92) relationships and in situ wind speeds, and estimated emission rates of methane from the East China Sea and the Yellow Sea range from 7.05 x 10(-2) - 12.0 x 10(-2) Tg x a(-1) and 1.17 x 10(-2) - 2.20 x 10(-2) Tg x a(-1), respectively.	Thioguanine	397-399	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
23671037-1	2013	OBJECTIVE: Investigation was conducted to understand the mechanism of action of diacylglycerol acyltransferase 1 (DGAT1) using small molecules DGAT1 inhibitors, compounds K and L. DESIGN AND METHODS: Biochemical and stable-label tracer approaches were applied to interrogate the functional activities of compounds K and L on TG synthesis and changes of carbon flow.	Thioguanine	325-327	diacylglycerol O-acyltransferase 1	Mus musculus	80-112
23671037-1	2013	OBJECTIVE: Investigation was conducted to understand the mechanism of action of diacylglycerol acyltransferase 1 (DGAT1) using small molecules DGAT1 inhibitors, compounds K and L. DESIGN AND METHODS: Biochemical and stable-label tracer approaches were applied to interrogate the functional activities of compounds K and L on TG synthesis and changes of carbon flow.	Thioguanine	325-327	diacylglycerol O-acyltransferase 1	Mus musculus	114-119
23853482-8	2013	Among those who received EGFR-TKI therapy, PFS was also longer in the low-TG2 group than in the high-TG 2 group (11.0 vs. 2.0 months; P=0.013).	Thioguanine	74-76	epidermal growth factor receptor	Homo sapiens	25-29
23790376-2	2013	Here we use a magnetic method to monitor the Brownian rotation of a quasi-spherical cage-shaped protein, apoferritin, approaching the glass transition Tg in a freeze-concentrated buffer (Tris-HCl).	Thioguanine	151-153	ferritin heavy chain 1	Homo sapiens	105-116
23769104-0	2013	Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity.	Thioguanine	181-194	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	84-130
23564081-7	2013	In LPS-challenged mice injected with rAAV-apoA-I-GFP, viral particles and human apoA-I were detected in the livers, total plasma human apoA-I levels were grammatically increased; HDL-cholesterol level was significantly increased, TG and TC were slightly increased.	Thioguanine	230-232	apolipoprotein A-I	Mus musculus	42-48
21978733-4	2013	The aim of this study was to assess the association of new GPIHBP1 gene variants with hyperTG (fasting plasma TG values &gt;= 2.0 mmol/L).	Thioguanine	91-93	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	Homo sapiens	59-66
23349019-3	2013	TRIT1 rs11581557 T&gt;G TG was associated with lymph node metastasis (TG versus TT/GG, adjusted OR, 1.64).	Thioguanine	24-26	tRNA isopentenyltransferase 1	Homo sapiens	0-5
23225194-9	2013	Flaxseed oil diet significantly up-regulated the key transcription factor peroxisome proliferator-activated receptor-alpha (PPAR-alpha ) and down-regulated sterol regulatory element-binding protein-1 (SREBP-1) in diabetic rats, which would have increased beta-oxidation of fatty acids and concomitantly reduced lipogenesis respectively, thereby reducing TG levels.	Thioguanine	354-356	sterol regulatory element binding transcription factor 1	Rattus norvegicus	201-208
23218882-5	2013	RESULTS: MDM2-rs2279744 and p14(ARF)-rs3731217 were associated with a significantly increased risk of DTC (MDM2-rs2279744: TT versus TG/GG; OR, 1.5; 95% CI, 1.1-2.0; p14(ARF)-rs3731217: TG/GG versus TT; OR, 1.7; 95% CI, 1.2-2.3).	Thioguanine	133-135	MDM2 proto-oncogene	Homo sapiens	9-13
23218882-5	2013	RESULTS: MDM2-rs2279744 and p14(ARF)-rs3731217 were associated with a significantly increased risk of DTC (MDM2-rs2279744: TT versus TG/GG; OR, 1.5; 95% CI, 1.1-2.0; p14(ARF)-rs3731217: TG/GG versus TT; OR, 1.7; 95% CI, 1.2-2.3).	Thioguanine	133-135	cyclin dependent kinase inhibitor 2A	Homo sapiens	28-31
23218882-5	2013	RESULTS: MDM2-rs2279744 and p14(ARF)-rs3731217 were associated with a significantly increased risk of DTC (MDM2-rs2279744: TT versus TG/GG; OR, 1.5; 95% CI, 1.1-2.0; p14(ARF)-rs3731217: TG/GG versus TT; OR, 1.7; 95% CI, 1.2-2.3).	Thioguanine	133-135	MDM2 proto-oncogene	Homo sapiens	107-111
23218882-5	2013	RESULTS: MDM2-rs2279744 and p14(ARF)-rs3731217 were associated with a significantly increased risk of DTC (MDM2-rs2279744: TT versus TG/GG; OR, 1.5; 95% CI, 1.1-2.0; p14(ARF)-rs3731217: TG/GG versus TT; OR, 1.7; 95% CI, 1.2-2.3).	Thioguanine	186-188	MDM2 proto-oncogene	Homo sapiens	9-13
23218882-5	2013	RESULTS: MDM2-rs2279744 and p14(ARF)-rs3731217 were associated with a significantly increased risk of DTC (MDM2-rs2279744: TT versus TG/GG; OR, 1.5; 95% CI, 1.1-2.0; p14(ARF)-rs3731217: TG/GG versus TT; OR, 1.7; 95% CI, 1.2-2.3).	Thioguanine	186-188	cyclin dependent kinase inhibitor 2A	Homo sapiens	28-31
23218882-5	2013	RESULTS: MDM2-rs2279744 and p14(ARF)-rs3731217 were associated with a significantly increased risk of DTC (MDM2-rs2279744: TT versus TG/GG; OR, 1.5; 95% CI, 1.1-2.0; p14(ARF)-rs3731217: TG/GG versus TT; OR, 1.7; 95% CI, 1.2-2.3).	Thioguanine	186-188	MDM2 proto-oncogene	Homo sapiens	107-111
23400925-5	2013	Unlike Hg, nearly constant TSe concentrations were observed at 248 +- 179 ng g(-1) in the food web, and the TSe-to-THg molar ratio was predicted by log10 (CTSe /CTHg ) = -0.10 x delta(15) N (%) +2.8, R(2)  =0.60.	Thioguanine	115-118	cathepsin E	Homo sapiens	155-159
23630575-2	2013	Here we identify a regulatory region sufficient for accurate in vivo expression of synaptophysin (SYP), a common marker of neuroendocrine differentiation, and report generation of Tg(Syp-EGFP(loxP)-DTA)147(Ayn) (SypELDTA) mice suitable for flexible organ-specific ablation of neuroendocrine cells.	Thioguanine	180-182	synaptophysin	Mus musculus	183-186
23407052-2	2013	TPMT metabolizes the thiopurines 6-mercaptopurine, 6-thioguanine, and azathioprine, drugs that are widely used for treatment of acute leukemias, inflammatory bowel diseases, and other disorders of immune regulation.	Thioguanine	51-64	thiopurine S-methyltransferase	Homo sapiens	0-4
23377281-4	2013	NT5C2 mutant proteins show increased nucleotidase activity in vitro and conferred resistance to chemotherapy with 6-mercaptopurine and 6-thioguanine when expressed in ALL lymphoblasts.	Thioguanine	135-148	5'-nucleotidase, cytosolic II	Homo sapiens	0-5
23312786-3	2013	RESULTS: Multivariate analysis revealed that 23.5% of endogenous CETP activity variability was explained by plasma LDL-C (12.0%), HDL-C (6.4%) and TG (4.4%) whereas sex and BMI accounted together for only 0.7% of its variability.	Thioguanine	147-149	cholesteryl ester transfer protein	Homo sapiens	65-69
23844534-1	2013	BACKGROUND: Thiopurine S-Methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs, such as 6-mercaptopurine, 6-thioguanine and azathioprine, leading to their inactivation.	Thioguanine	125-138	thiopurine S-methyltransferase	Homo sapiens	12-42
23844534-1	2013	BACKGROUND: Thiopurine S-Methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs, such as 6-mercaptopurine, 6-thioguanine and azathioprine, leading to their inactivation.	Thioguanine	125-138	thiopurine S-methyltransferase	Homo sapiens	44-48
23261612-4	2013	Thermogravimetric-differential thermal analysis (TG-DTA) shows the onset decomposition temperatures to be 255, 238, 251 and 250 C for pure, Ba(2+), Ca(2+) and Mg(2+) doped KAP crystals respectively.	Thioguanine	49-51	napsin A aspartic peptidase	Homo sapiens	172-175
22827297-8	2013	The serum salusin beta levels were correlated positively with HOMA-IR, TG, LDL-C, LH, FSH, and total testosterone levels.	Thioguanine	71-73	torsin family 2 member A	Homo sapiens	10-22
23147266-9	2013	The fully adjusted model showed that those who carry an Apo E gene E3 allele or have high TG level have an odds ratio of 2.35 (95% CI:1.3-4.25) for having low HDL compared to other subjects.	Thioguanine	90-92	apolipoprotein E	Homo sapiens	56-61
23147266-11	2013	CONCLUSION: The results showed that logic regression is a powerful method to find the interaction between high TG level and Apo E polymorphism associated with low HDL.	Thioguanine	111-113	apolipoprotein E	Homo sapiens	124-129
23103710-10	2013	CONCLUSION: The present study indicates that MTHFR C677T polymorphism through affecting on TG level, lipid peroxidation and oxidative stress might be involved in the pathogenesis of severe preeclampsia.	Thioguanine	91-93	methylenetetrahydrofolate reductase	Homo sapiens	45-50
23255335-4	2013	Like Dmrt1(-/-) mice, male Dmrt1(-/-) transgenic mice (Dmrt1(-/-;tg)) were infertile, while female mice were fertile.	Thioguanine	65-67	doublesex and mab-3 related transcription factor 1	Mus musculus	27-53
23160218-7	2013	An oral gavage of [(3)H]TG-containing olive oil revealed that caspase-1 deficiency reduced TG absorption and subsequent uptake of TG-derived FA in liver, muscle, and adipose tissue.	Thioguanine	24-26	caspase 1	Mus musculus	62-71
23160218-10	2013	The current study reveals a novel function for caspase-1, or caspase-1-cleaved substrates, in controlling intestinal TG absorption and hepatic TG secretion.	Thioguanine	117-119	caspase 1	Mus musculus	47-56
23160218-10	2013	The current study reveals a novel function for caspase-1, or caspase-1-cleaved substrates, in controlling intestinal TG absorption and hepatic TG secretion.	Thioguanine	117-119	caspase 1	Mus musculus	61-70
23079705-4	2013	In general, carriers of the A insertion of RXRA rs11381416 polymorphism showed higher levels of triglyceride (TG; 1.80 +- 1.20 vs. 1.52 +- 1.20 mmol/L; P = 0.020).	Thioguanine	110-112	retinoid X receptor alpha	Homo sapiens	43-47
23079705-5	2013	Moreover, sexual dimorphic association was found (gender*NR1I3 rs2501873 genotype interaction P &lt; 0.001), males with NR1I3 rs2501873 G/G genotype had lower TG levels (ANCOVA, P = 0.009).	Thioguanine	159-161	nuclear receptor subfamily 1 group I member 3	Homo sapiens	57-62
23079705-5	2013	Moreover, sexual dimorphic association was found (gender*NR1I3 rs2501873 genotype interaction P &lt; 0.001), males with NR1I3 rs2501873 G/G genotype had lower TG levels (ANCOVA, P = 0.009).	Thioguanine	159-161	nuclear receptor subfamily 1 group I member 3	Homo sapiens	120-125
23289013-6	2013	Findings suggest that Visfatin RS4730153 homozygous GG genotype may effect adjustment of glucose and lipid metabolism in obese children and adolescents by reducing TG levels and increasing insulin sensitivity to exercise.	Thioguanine	164-166	nicotinamide phosphoribosyltransferase	Homo sapiens	22-30
22898252-11	2013	Insulin infusion decreases plasma and intramuscular fatty acid availability and thereby decreases TG synthesis.	Thioguanine	98-100	insulin	Oryctolagus cuniculus	0-7
22729917-10	2012	A significant association between the mutated genotype of HindIII polymorphism and decreased HDL-C level and increased ApoB/ApoA-I ratio and TG level was showed.	Thioguanine	141-143	apolipoprotein B	Homo sapiens	119-123
23555045-3	2013	We have previously shown that knockdown of HPRT using lentiviral delivered shRNA facilitates efficient selection of transduced murine hematopoietic progenitor cells (HPC) using 6-thioguanine (6TG).	Thioguanine	177-190	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	43-47
23555045-3	2013	We have previously shown that knockdown of HPRT using lentiviral delivered shRNA facilitates efficient selection of transduced murine hematopoietic progenitor cells (HPC) using 6-thioguanine (6TG).	Thioguanine	192-195	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	43-47
24061374-9	2012	The experimental results of TG-DTA showed that the Co(III) complex contained ethanol and crystal water in the first two stages.	Thioguanine	28-30	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	51-58
22810848-10	2012	The volume of Lb was significantly reduced and mRNA levels of ABCA3 transporter tended to be lower in TG versus CG.	Thioguanine	102-104	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	62-67
23896872-4	2013	The identification and selective expansion of mutant lymphocytes are based upon the phenotypic properties of Hprt- and Pig-a-deficient cells, i.e., resistance to the purine analog, 6-thioguanine, or to the bacterial toxin, proaerolysin.	Thioguanine	181-194	hypoxanthine phosphoribosyltransferase 1	Sus scrofa	109-113
23896872-4	2013	The identification and selective expansion of mutant lymphocytes are based upon the phenotypic properties of Hprt- and Pig-a-deficient cells, i.e., resistance to the purine analog, 6-thioguanine, or to the bacterial toxin, proaerolysin.	Thioguanine	181-194	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	119-124
22273754-10	2012	Hypercholesterolemic APP(OSK)-Tg mice, but not control APP(OSK)-Tg mice or hypercholesterolemic non-Tg littermates, exhibited impaired spatial reference memory, which was accompanied with intraneuronal accumulation of Abeta oligomers, reduced synaptophysin immunoreactivity, and abnormal tau phosphorylation in the hippocampus.	Thioguanine	30-32	synaptophysin	Mus musculus	243-256
22729917-10	2012	A significant association between the mutated genotype of HindIII polymorphism and decreased HDL-C level and increased ApoB/ApoA-I ratio and TG level was showed.	Thioguanine	141-143	apolipoprotein A1	Homo sapiens	124-130
22974544-3	2012	MATERIALS AND METHODS: Nitric oxide (NO) production and as inducible nitric oxide synthase (iNOS) expression were examined in TG-elicited peritoneal macrophages and RAW 264.7 cells.	Thioguanine	126-128	nitric oxide synthase 2, inducible	Mus musculus	92-96
22911512-5	2012	Our results show that the ApoCIII transgenic mice displayed increased serum TG levels, enhanced generation of ROS and impaired insulin content in pancreatic beta-cells.	Thioguanine	76-78	apolipoprotein C-III	Mus musculus	26-33
22653994-7	2012	In parallel, the ratio of reduced to oxidized glutathione (GSH/GSSG) was unaltered in sod2(Tg) in chow-fed mice, but was increased in HF-fed sod2(Tg) and both chow- and HF-fed mcat(Tg) and mtAO.	Thioguanine	146-148	superoxide dismutase 2, mitochondrial	Mus musculus	141-145
22653994-7	2012	In parallel, the ratio of reduced to oxidized glutathione (GSH/GSSG) was unaltered in sod2(Tg) in chow-fed mice, but was increased in HF-fed sod2(Tg) and both chow- and HF-fed mcat(Tg) and mtAO.	Thioguanine	146-148	malonyl CoA:ACP acyltransferase (mitochondrial)	Mus musculus	176-180
22709655-12	2012	MyoD and creatine kinase in the injured muscle was also significantly increased in the Tg.	Thioguanine	87-89	myogenic differentiation 1	Mus musculus	0-4
22941066-4	2012	The HPRT gene mutant cells induced by the mutagen were selected by 6-thioguanine (6-TG) and the cell"s kinetic growth curve monitored by a real-time cell electronic sensor (RT-CES) system.	Thioguanine	67-80	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	4-8
22941066-4	2012	The HPRT gene mutant cells induced by the mutagen were selected by 6-thioguanine (6-TG) and the cell"s kinetic growth curve monitored by a real-time cell electronic sensor (RT-CES) system.	Thioguanine	82-86	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	4-8
23040436-7	2012	An alternative strategy involving coadministration of methylthioadenosine and high-dose 6-thioguanine has been proposed and may prove to be selectively toxic to MTAP-deficient uncommon lymphomas.	Thioguanine	88-101	methylthioadenosine phosphorylase	Homo sapiens	161-165
22612669-10	2012	Based on genetic variations near the IL28B gene (rs8099917), SVR was 44.1% (15/34) in patients with TT and 0% (0/11) in patients with TG (P = 0.008).	Thioguanine	134-136	interferon lambda 3	Homo sapiens	37-42
23202632-8	2012	Correlation analysis showed that the plasma RBP4 level was significantly correlated with BMI, FPG, FIns, 2hPIns, HOMA-IR, TG, HDL-C, UA, and hsCRP (r=0.259, 0.331, 0.582, 0.452, 0.600, 0.236, -0.290, 0.243, 0.231, respectively; all P&gt;0.05).	Thioguanine	122-124	retinol binding protein 4	Homo sapiens	44-48
22930507-7	2012	As significant or marginal significant determinants of non-sustained virological response regardless of rapid virological response, multivariate analysis identified IL28B rs8099917 genotype TG + GG and lower level of albumin.	Thioguanine	190-192	interferon lambda 3	Homo sapiens	165-170
22735545-6	2012	By lipoprotein analysis, ddY mice showed increases in chylomicron- and VLDL-sized TG fractions (remnants and VLDL) after fat load.	Thioguanine	82-84	CD320 antigen	Mus musculus	71-75
22512822-9	2012	The atherogenic ApoB/ApoA1 ratio from ages 14 to 19 is lower in black girls, and positively associated with hyperandrogenism, menstrual cyclicity &gt;=42 days, BMI, TG, and the metabolic syndrome, facilitating an adolescent approach to primary prevention of cardiovascular disease.	Thioguanine	165-167	apolipoprotein B	Homo sapiens	16-20
22972540-5	2012	TPMT kd cells were more sensitive to 6-mercaptopurine (6-MP) (10 mumol/L) and 6-thioguanine (6-TG) (8 mumol/L) than wild-type (wt) cells, (32% versus 20%) and (18% versus 9%), respectively.	Thioguanine	78-91	thiopurine S-methyltransferase	Homo sapiens	0-4
22972540-5	2012	TPMT kd cells were more sensitive to 6-mercaptopurine (6-MP) (10 mumol/L) and 6-thioguanine (6-TG) (8 mumol/L) than wild-type (wt) cells, (32% versus 20%) and (18% versus 9%), respectively.	Thioguanine	93-97	thiopurine S-methyltransferase	Homo sapiens	0-4
22972540-7	2012	6-TG activity was also more affected by TPMT levels than was 6-MP as reflected by IC60, concentrations that is, 6-MP [4.6 mumol/L (wt) and 4.7 mumol/L (kd)], 6-TG [2.7 mumol/L (wt) and 0.8 mumol/L (kd)].	Thioguanine	0-4	thiopurine S-methyltransferase	Homo sapiens	40-44
22925530-6	2012	We investigated the effect of native beta(2)GPI and phospholipid-bound beta(2)GPI on thrombin generation (TG).	Thioguanine	106-108	coagulation factor II, thrombin	Homo sapiens	85-93
22714024-3	2012	The compound Cs-1 was characterized by elemental analysis, thermogravimetric/differential thermal analysis (TG/DTA), Fourier transform infrared (FTIR) and UV-visible spectroscopy, solution (1)H and (31)P nuclear magnetic resonance (NMR), and X-ray crystallography.	Thioguanine	108-110	chorionic somatomammotropin hormone 1	Homo sapiens	13-17
22925530-8	2012	On the contrary, beta(2)GPI preincubated with phospholipids significantly inhibited TG triggered with low TF concentration, suggesting an effect on the intrinsic pathway.	Thioguanine	84-86	apolipoprotein H	Homo sapiens	17-27
22956830-6	2012	We observed a dose-related delay in disease onset, a reduction in symptom severity, and an extension of survival in rapamycin-treated Tg(PrP-A116V) mice.	Thioguanine	134-136	prion protein	Mus musculus	137-140
22712870-3	2012	AIMS/METHODS: To evaluate the in vitro effect of LMWH on thrombin generation (TG) in cirrhotic patients at different stages of liver disease.	Thioguanine	78-80	coagulation factor II, thrombin	Homo sapiens	57-65
22825330-0	2012	Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.	Thioguanine	55-68	methylthioadenosine phosphorylase	Homo sapiens	90-94
22807504-9	2012	CONCLUSIONS: The monoclonal antibody G11-6 is useful for detecting oxidized small LDLs in normal controls and oxidized TG-rich LDLs in patients with severe liver disease.	Thioguanine	119-121	ribosomal protein L37	Homo sapiens	37-42
22825330-7	2012	Extracellular MTA can also protect mouse mesothelioma cells from killing by 6-TG or the drug L-alanosine in an MTAP-dependent manner.	Thioguanine	76-80	methylthioadenosine phosphorylase	Mus musculus	111-115
22825330-8	2012	In addition, MTA can protect non-transformed MTAP (+)  mouse embryo fibroblasts from 6TG toxicity.	Thioguanine	85-88	methylthioadenosine phosphorylase	Mus musculus	45-49
22617755-6	2012	With respect to the other inseparable conditions of insulin resistance and hyperinsulinemia, recent studies demonstrate that increased hepatic VLDL-TG production precedes the insulin resistance-associated impairment of the regulation of hepatic glucose production, whereas isolated chronic hyperinsulinemia (insulinoma) was not associated with increased VLDL-TG production.	Thioguanine	148-150	insulin	Homo sapiens	80-87
22617755-7	2012	Insulin has been shown to have acute potent temporary suppressing effect on VLDL-TG production and new data demonstrates that increased glucagon reduces VLDL-TG production.	Thioguanine	81-83	insulin	Homo sapiens	0-7
22617755-7	2012	Insulin has been shown to have acute potent temporary suppressing effect on VLDL-TG production and new data demonstrates that increased glucagon reduces VLDL-TG production.	Thioguanine	158-160	insulin	Homo sapiens	0-7
22518822-4	2012	The adoptive transfer of highly purified T cells from naive TCR-Tg, arthritic TCR-Tg or arthritic wild-type mice induced arthritis in SCID recipients, but the onset and severity of the disease were dependent on the sequential events of the T cell-supported reconstitution of PG-specific B cells and autoantibodies.	Thioguanine	64-66	T cell receptor alpha variable 6-3	Mus musculus	60-63
22562833-5	2012	SOCS2(-/-) mice exhibited increased hepatic TG secretion by 77.6% (P&lt;0.001) as compared with wild-type control mice and were protected from high-fat-diet (HFD)-induced hepatic steatosis, showing 49.3% (P&lt;0.01) reduction in liver TG levels compared to HFD-fed wild-type littermates.	Thioguanine	44-46	suppressor of cytokine signaling 2	Mus musculus	0-5
22564527-7	2012	No changes were observed in the levels of thioredoxin reductase 1 (TrxR1); however, measurements of TrxR1 activity showed a 42.7+-8% reduction in Tg mice versus Wt at 14 months of age.	Thioguanine	146-148	thioredoxin reductase 1	Mus musculus	100-105
22518822-4	2012	The adoptive transfer of highly purified T cells from naive TCR-Tg, arthritic TCR-Tg or arthritic wild-type mice induced arthritis in SCID recipients, but the onset and severity of the disease were dependent on the sequential events of the T cell-supported reconstitution of PG-specific B cells and autoantibodies.	Thioguanine	82-84	T cell receptor alpha variable 6-3	Mus musculus	78-81
21676499-4	2012	CA1 pyramidal neurons from Tg+ mice had narrower action potentials with faster decays than neurons from Tg- littermates.	Thioguanine	27-29	carbonic anhydrase 1	Mus musculus	0-3
22433787-8	2012	Further, RLP apoB100, but not RLP apoB48 was highly correlated with the increase of TG in the postprandial plasma.	Thioguanine	84-86	apolipoprotein B	Homo sapiens	13-20
22594254-1	2012	Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	130-143	thiopurine S-methyltransferase	Homo sapiens	0-30
23310938-9	2012	The increases in mean DBP were not significant in both groups but it was significantly greater in TG (p = 0.012).	Thioguanine	98-100	D-box binding PAR bZIP transcription factor	Homo sapiens	22-25
22222482-7	2012	LDLr expression in liver was increased significantly (p &lt; 0.05) and parallel to the change of serum TC and TG.	Thioguanine	110-112	low density lipoprotein receptor	Mus musculus	0-4
22402478-5	2012	TG-DTA studies show the decomposition temperatures to be 255  C, 232  C, 258  C and 264  C for pure, LA, Gly and LT doped KAP crystals respectively.	Thioguanine	0-2	napsin A aspartic peptidase	Homo sapiens	122-125
22459987-3	2012	We assessed the discordance between non-HDL-C and Apo-B targets in patients with diabetes with TG 200-499 mg/dl.	Thioguanine	95-97	apolipoprotein B	Homo sapiens	50-55
22427521-6	2012	For example, the protein level of the L-type Ca(2+) channel Ca(v)1.2 was higher in TG(CxT) compared with TG(CSQ).	Thioguanine	105-107	calsequestrin 1	Mus musculus	108-111
22427521-7	2012	Sarco(endo)plasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) expression was reduced in TG(CxT) compared with TG(CSQ), whereas JUN expression and [(3)H]ryanodine binding were lower in both TG(CxT) and TG(CSQ) compared with wild-type hearts.	Thioguanine	82-84	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	47-54
22594254-1	2012	Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	130-143	thiopurine S-methyltransferase	Homo sapiens	32-36
22323339-8	2012	There was a significantly positive correlation between MMP-2 level with neopterin, total cholesterol and TG levels and negative correlation with HDL-C level in SLE patients with CVD.	Thioguanine	105-107	matrix metallopeptidase 2	Homo sapiens	55-60
21955218-8	2012	CONCLUSION: Our results support the hypothesis that TG may be involved in the pathogenesis of MVD in diabetic nephropathy as for the first time, we could show that patients with T2DM in different stages of diabetic nephropathy had disturbances in thrombin generation.	Thioguanine	52-54	coagulation factor II, thrombin	Homo sapiens	247-255
22387725-1	2012	The APOA5 -1131 T/C polymorphism (rs662799) exhibits a very strong association with elevated TG levels in different racial groups.	Thioguanine	93-95	apolipoprotein A5	Homo sapiens	4-9
22461740-5	2012	The work in our laboratory has shown that LRP6 also plays a key role in lipoprotein and TG clearance, glucose homoeostasis, and atherosclerosis.	Thioguanine	88-90	LDL receptor related protein 6	Homo sapiens	42-46
21938428-1	2012	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine.	Thioguanine	110-123	thiopurine S-methyltransferase	Homo sapiens	0-28
21938428-1	2012	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine.	Thioguanine	110-123	thiopurine S-methyltransferase	Homo sapiens	30-34
22401797-8	2012	Apyrase and antagonists of the platelet adenosine diphosphate (ADP) receptors, P2Y1 and P2Y12, completely inhibited Tg-induced platelet aggregation, which was not sensitive to indomethacin or SQ29548 inhibition.	Thioguanine	116-118	purinergic receptor P2Y1	Rattus norvegicus	79-83
22401797-8	2012	Apyrase and antagonists of the platelet adenosine diphosphate (ADP) receptors, P2Y1 and P2Y12, completely inhibited Tg-induced platelet aggregation, which was not sensitive to indomethacin or SQ29548 inhibition.	Thioguanine	116-118	purinergic receptor P2Y12	Rattus norvegicus	88-93
22401797-9	2012	Furthermore, ADP receptor antagonists inhibited Tg-induced a-granule secretion, and blockade of the P2Y1 receptor prevented Tg-induced platelet shape changes.	Thioguanine	124-126	purinergic receptor P2Y1	Rattus norvegicus	100-104
22401797-11	2012	CONCLUSION: We identified that Tg directly induces platelet activation and demonstrated that Tg-induced platelet activation depends on dense granule secretion of ADP, which in turn activates the P2Y1 and P2Y12 receptor signaling pathways.	Thioguanine	31-33	purinergic receptor P2Y1	Rattus norvegicus	195-199
22401797-11	2012	CONCLUSION: We identified that Tg directly induces platelet activation and demonstrated that Tg-induced platelet activation depends on dense granule secretion of ADP, which in turn activates the P2Y1 and P2Y12 receptor signaling pathways.	Thioguanine	31-33	purinergic receptor P2Y12	Rattus norvegicus	204-209
22401797-11	2012	CONCLUSION: We identified that Tg directly induces platelet activation and demonstrated that Tg-induced platelet activation depends on dense granule secretion of ADP, which in turn activates the P2Y1 and P2Y12 receptor signaling pathways.	Thioguanine	93-95	purinergic receptor P2Y1	Rattus norvegicus	195-199
22401797-11	2012	CONCLUSION: We identified that Tg directly induces platelet activation and demonstrated that Tg-induced platelet activation depends on dense granule secretion of ADP, which in turn activates the P2Y1 and P2Y12 receptor signaling pathways.	Thioguanine	93-95	purinergic receptor P2Y12	Rattus norvegicus	204-209
22042485-11	2012	Correlation analysis showed serum chemerin levels were significantly associated with TG levels, TC levels, fasting serum insulin, HOMA-IR and MetS (all P &lt; 0.05).	Thioguanine	85-87	retinoic acid receptor responder 2	Homo sapiens	34-42
22281106-7	2012	Fluoxetine administration also increased levels of the neurotrophic factors, GDNF (glial-derived neurotrophic factor) and BDNF (brain-derived neurotrophic factor) in the MBP1-halphasyn tg mice compared to vehicle-treated tg mice.	Thioguanine	185-187	glial cell line derived neurotrophic factor	Mus musculus	77-81
22281106-7	2012	Fluoxetine administration also increased levels of the neurotrophic factors, GDNF (glial-derived neurotrophic factor) and BDNF (brain-derived neurotrophic factor) in the MBP1-halphasyn tg mice compared to vehicle-treated tg mice.	Thioguanine	185-187	brain derived neurotrophic factor	Mus musculus	122-126
22281106-7	2012	Fluoxetine administration also increased levels of the neurotrophic factors, GDNF (glial-derived neurotrophic factor) and BDNF (brain-derived neurotrophic factor) in the MBP1-halphasyn tg mice compared to vehicle-treated tg mice.	Thioguanine	185-187	brain derived neurotrophic factor	Mus musculus	128-161
22281106-7	2012	Fluoxetine administration also increased levels of the neurotrophic factors, GDNF (glial-derived neurotrophic factor) and BDNF (brain-derived neurotrophic factor) in the MBP1-halphasyn tg mice compared to vehicle-treated tg mice.	Thioguanine	185-187	proteoglycan 2, bone marrow	Mus musculus	170-174
22031092-6	2012	Moreover, the premature mortality, which was associated with chronic inflammation, as well as the pathologic alterations of hepatocytes observed in GH(tg) mice, were not observed in GH(tg) animals lacking STAT5.	Thioguanine	151-153	growth hormone	Mus musculus	148-150
22309488-19	2012	HbA1c associates with atherogenic dyslipidemia particularly with TG and TG/HDL-C ratio, but not with TC, HDL-C, or LDL-C. HbA1c is not associated with hs-CRP, and with functional fitness and aerobic endurance.	Thioguanine	65-67	hemoglobin subunit alpha 1	Homo sapiens	0-4
22135386-4	2012	METHODS AND RESULTS: We resequenced protein coding regions of 3 genes with established roles (APOC2, GPIHBP1, LMF1) and 2 genes recently implicated (CREB3L3 and ZHX3) in TG metabolism.	Thioguanine	170-172	cAMP responsive element binding protein 3 like 3	Homo sapiens	149-156
22524835-4	2012	The most significant association was seen for IL2 variant rs2069762 (OR(TG+GG) vs. TT=3.43 (1.29-9.11), P(trend)=0.002, minP=0.005).	Thioguanine	72-74	interleukin 2	Homo sapiens	46-49
21872972-8	2012	Although a multiplicative interaction was not observed, the protective effect of beta-carotene intake on breast cancer risk was observed predominantly in individuals with the TG:TG diplotype of NOS3 (OR = 0.68) but not observed with others diplotype.	Thioguanine	175-177	nitric oxide synthase 3	Homo sapiens	194-198
22190473-7	2012	Like Tg(cyp26a1:eYFP)nju1/+, which harbor eYFP driven by wild-type cyp26a1 promoter, the reporter in Tg(cyp26a1-R3mut:eYFP)nju3/+ responds to excessive RA dose dependently.	Thioguanine	5-7	cytochrome P450, family 26, subfamily A, polypeptide 1	Danio rerio	8-15
22105741-7	2012	The results showed a significant association between TG, HDL-C, HDL(2), Apo AI, and Apo B levels and the presence of some alleles in the polymorphisms studied.	Thioguanine	53-55	apolipoprotein B	Homo sapiens	84-89
21993540-6	2012	Ca(2+) release induced by TG was decreased in Bcl-2 cells, however, it was greater in Caff induced Ca(2+) rise.	Thioguanine	26-28	BCL2, apoptosis regulator	Rattus norvegicus	46-51
21905017-10	2012	Inhibition of Th17 cell differentiation under an in vitro condition favoring Th17 cell differentiation was observed in both T-bet-Tg mice and T-bet-Tg/IFNgamma-/- mice.	Thioguanine	130-132	T-box 21	Mus musculus	124-129
22001673-1	2012	Purine analogs such as 6-thioguanine (6TG) cause myelotoxicity upon conversion into nucleotides by hypoxanthine-guanine phosphoribosyltransferase (HPRT).	Thioguanine	23-36	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	99-145
23163112-3	2012	TPMT is a phase 2 detoxification enzyme that catalyzes the S-methylation of thiopurine drugs such as thioguanine and 6-mercaptopurine.	Thioguanine	101-112	thiopurine S-methyltransferase	Homo sapiens	0-4
22001673-1	2012	Purine analogs such as 6-thioguanine (6TG) cause myelotoxicity upon conversion into nucleotides by hypoxanthine-guanine phosphoribosyltransferase (HPRT).	Thioguanine	23-36	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	147-151
22001673-1	2012	Purine analogs such as 6-thioguanine (6TG) cause myelotoxicity upon conversion into nucleotides by hypoxanthine-guanine phosphoribosyltransferase (HPRT).	Thioguanine	38-41	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	99-145
22001673-1	2012	Purine analogs such as 6-thioguanine (6TG) cause myelotoxicity upon conversion into nucleotides by hypoxanthine-guanine phosphoribosyltransferase (HPRT).	Thioguanine	38-41	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	147-151
22001673-5	2012	At appropriate doses, 6TG induced selective myelotoxicity without any adverse effects on extrahematopoietic tissues in HPRT wild-type mice, while hematopoietic stem cells deficient in HPRT activity were highly resistant to its cytotoxic effects.	Thioguanine	22-25	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	119-123
23155779-4	2012	We identified 13 SNPs for four genes (CSMD1, NFE2L1, CBX1, and SKAP1) associated with a new multivariate phenotype defined as low levels of low density lipoprotein cholesterol (LDL-C &lt; or = 100 mg/dl) and high levels of triglycerides (TG &gt; or = 180 mg/dl).	Thioguanine	238-240	CUB and Sushi multiple domains 1	Homo sapiens	38-43
23155779-4	2012	We identified 13 SNPs for four genes (CSMD1, NFE2L1, CBX1, and SKAP1) associated with a new multivariate phenotype defined as low levels of low density lipoprotein cholesterol (LDL-C &lt; or = 100 mg/dl) and high levels of triglycerides (TG &gt; or = 180 mg/dl).	Thioguanine	238-240	chromobox 1	Homo sapiens	53-57
23155779-4	2012	We identified 13 SNPs for four genes (CSMD1, NFE2L1, CBX1, and SKAP1) associated with a new multivariate phenotype defined as low levels of low density lipoprotein cholesterol (LDL-C &lt; or = 100 mg/dl) and high levels of triglycerides (TG &gt; or = 180 mg/dl).	Thioguanine	238-240	src kinase associated phosphoprotein 1	Homo sapiens	63-68
22253614-7	2012	Adiponectin was significantly, positively associated with HDL and inversely associated with glucose, HbA1c, ALT, AST, TG, HOMA-IR.	Thioguanine	118-120	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
23019973-5	2012	In women, PLA2 levels positively correlated with apoA-1 (main HDLP apoprotein) content (r = 0.51, p &lt; 0.03); in men, PLA2 negatively correlated with TG (r = -0.38, p &lt; 0.01); in subjects with homogeneous ACP PLA2 positively correlated with LP(a) (r = -.38, p &lt; 0.03).	Thioguanine	152-154	phospholipase A2 group IIA	Homo sapiens	120-124
23019973-5	2012	In women, PLA2 levels positively correlated with apoA-1 (main HDLP apoprotein) content (r = 0.51, p &lt; 0.03); in men, PLA2 negatively correlated with TG (r = -0.38, p &lt; 0.01); in subjects with homogeneous ACP PLA2 positively correlated with LP(a) (r = -.38, p &lt; 0.03).	Thioguanine	152-154	phospholipase A2 group IIA	Homo sapiens	120-124
22523530-9	2012	Further, improvement in myocardial functional parameters 30 d after MI was observed including decreased LVIDs, LVIDd, increased ejection fraction and, fractional shortening was also observed in the Grx-1(Tg/+)MI group as compared to the WTMI animals.	Thioguanine	204-206	glutaredoxin	Mus musculus	198-203
23285142-8	2012	Electrocardiogram demonstrated that premature ventricular contraction (PVC) was frequently (more than 20 beats/min) observed in 7 of 10 vehicle-treated Galpha(q)-TG but in none of 10 nicorandil-treated Galpha(q)-TG.	Thioguanine	162-164	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	152-161
23209702-6	2012	RESULTS: Of the 8 polymorphisms, after adjusting for multiple comparisons, we found a significant association between one variant (rs2295080) in the promoter of MTOR and reduced RCC risk (P = 0.005, OR = 0.74, 95%CI = 0.59-0.91, TG/GG vs. TT).	Thioguanine	229-231	mechanistic target of rapamycin kinase	Homo sapiens	161-165
22662200-5	2012	An acyclic guanosine prodrug analog, valaciclovir, was shown to stabilize GDA to the same degree as the natural substrate, guanine, with a DeltaT(agg) around 7 C. Aciclovir, penciclovir, ganciclovir, thioguanine and mercaptopurine were also identified as ligands for GDA.	Thioguanine	200-211	guanine deaminase	Homo sapiens	74-77
22662200-7	2012	Several ligands were identified for UPP1: vidarabine, an antiviral nucleoside analog, as well as trifluridine, idoxuridine, floxuridine, zidovudine, telbivudine, fluorouracil and thioguanine caused concentration-dependent stabilization of UPP1.	Thioguanine	179-190	uridine phosphorylase 1	Homo sapiens	36-40
23251567-9	2012	RESULTS: Tg dose-dependently stimulated rat myometrial contractions as well as MLC20 phosphorylation in vitro, which could be completely suppressed by an inhibitor of myosin light chain kinase (MLCK).	Thioguanine	9-11	myosin light chain 12B	Rattus norvegicus	79-84
23251567-9	2012	RESULTS: Tg dose-dependently stimulated rat myometrial contractions as well as MLC20 phosphorylation in vitro, which could be completely suppressed by an inhibitor of myosin light chain kinase (MLCK).	Thioguanine	9-11	myosin light chain kinase	Rattus norvegicus	167-192
23251567-9	2012	RESULTS: Tg dose-dependently stimulated rat myometrial contractions as well as MLC20 phosphorylation in vitro, which could be completely suppressed by an inhibitor of myosin light chain kinase (MLCK).	Thioguanine	9-11	myosin light chain kinase	Rattus norvegicus	194-198
23251567-10	2012	Use of Ca(2+) channel blockers and kinase inhibitors demonstrated that Tg-induced myometrial contractions are mediated by activation of the phospholipase C (PLC)-inositol triphosphate (IP3) signaling pathway, resulting in increased MLC20 phosphorylation.	Thioguanine	71-73	myosin light chain 12B	Rattus norvegicus	232-237
23251567-11	2012	Furthermore, Y27632, a specific inhibitor of Rho kinase (ROK), notably suppressed Tg-stimulated myometrial contractions and decreased MLC20 phosphorylation.	Thioguanine	82-84	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	45-55
23251567-11	2012	Furthermore, Y27632, a specific inhibitor of Rho kinase (ROK), notably suppressed Tg-stimulated myometrial contractions and decreased MLC20 phosphorylation.	Thioguanine	82-84	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	57-60
22523530-10	2012	Moreover, attenuation of oxidative stress and apoptotic cardiomyocytes was observed in the Grx-1(Tg/+)MI group as compared to the WTMI animals.	Thioguanine	97-99	glutaredoxin	Mus musculus	91-96
21824519-3	2011	Homozygous mutation of Immp2l (Immp2l(Tg(Tyr)979Ove) or Immp2l(-/-)) elevates mitochondrial membrane potential, increases superoxide (O(2)(-)) production in the brain and impairs fertility.	Thioguanine	38-40	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	Mus musculus	23-29
22470429-2	2012	We sought to assess the effects of aspirin and statins on the thrombotic risk assessed by thrombin generation (TG) among patients with type II diabetes mellitus and no previous cardiovascular events.	Thioguanine	111-113	coagulation factor II, thrombin	Homo sapiens	90-98
21736770-8	2011	The increase in CCK was similar for Cas and Wh in the first 15 min, whereas for Cas-TG, the CCK release was significantly lower, but more sustained.	Thioguanine	84-86	cholecystokinin	Homo sapiens	92-95
21960661-1	2011	Our objective was to test the hypothesis that a common polymorphism in the hepatic lipase (HL) gene (LIPC -514C&gt;T, rs1800588) influences aerobic exercise training-induced changes in TG, very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) through genotype-specific increases in lipoprotein lipase (LPL) activity and that sex may affect these responses.	Thioguanine	185-187	lipase C, hepatic type	Homo sapiens	75-89
21960661-1	2011	Our objective was to test the hypothesis that a common polymorphism in the hepatic lipase (HL) gene (LIPC -514C&gt;T, rs1800588) influences aerobic exercise training-induced changes in TG, very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) through genotype-specific increases in lipoprotein lipase (LPL) activity and that sex may affect these responses.	Thioguanine	185-187	lipase C, hepatic type	Homo sapiens	101-105
21960661-7	2011	This suggests that the LIPC -514C&gt;T variant significantly affects training-induced anti-atherogenic changes in VLDL-TG, VLDL particles, and HDL through an association with increased LPL activity in CC subjects, which could guide therapeutic strategies to reduce CHD risk.	Thioguanine	119-121	lipase C, hepatic type	Homo sapiens	23-27
21960661-7	2011	This suggests that the LIPC -514C&gt;T variant significantly affects training-induced anti-atherogenic changes in VLDL-TG, VLDL particles, and HDL through an association with increased LPL activity in CC subjects, which could guide therapeutic strategies to reduce CHD risk.	Thioguanine	119-121	lipoprotein lipase	Homo sapiens	185-188
21824519-3	2011	Homozygous mutation of Immp2l (Immp2l(Tg(Tyr)979Ove) or Immp2l(-/-)) elevates mitochondrial membrane potential, increases superoxide (O(2)(-)) production in the brain and impairs fertility.	Thioguanine	38-40	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	Mus musculus	31-37
21810455-7	2011	Genotype frequencies for ADIPOQ (+45T/G) were 0.789 for TT, 0.164 for TG, and 0.0468 for GG.	Thioguanine	70-72	adiponectin, C1Q and collagen domain containing	Homo sapiens	25-31
22012070-6	2011	AT-independent thrombin inhibitors (melagatran, lepirudin, and active site blocked thrombin (IIai)) increased peak levels of TG (2.0, 1.6, and 2.2-fold, respectively) in the presence of 12 nM recombinant human soluble TM (rhsTM).	Thioguanine	125-127	coagulation factor II, thrombin	Homo sapiens	15-23
22012070-6	2011	AT-independent thrombin inhibitors (melagatran, lepirudin, and active site blocked thrombin (IIai)) increased peak levels of TG (2.0, 1.6, and 2.2-fold, respectively) in the presence of 12 nM recombinant human soluble TM (rhsTM).	Thioguanine	125-127	coagulation factor II, thrombin	Homo sapiens	83-91
21964592-11	2011	Hypothyroidism induced by low-iodine diet and oral propylthiouracil revealed a blunted TSH response in Pitx2(flox/-);Tg(Tshb-cre) mice.	Thioguanine	117-119	paired-like homeodomain transcription factor 2	Mus musculus	103-108
21964592-11	2011	Hypothyroidism induced by low-iodine diet and oral propylthiouracil revealed a blunted TSH response in Pitx2(flox/-);Tg(Tshb-cre) mice.	Thioguanine	117-119	thyroid stimulating hormone, beta subunit	Mus musculus	120-124
22662222-4	2012	Plasma TG levels were reduced in Slc10a2-deficient mice, and when challenged with a sucrose-rich diet, they displayed a reduced response in hepatic TG production as observed from the mRNA levels of several key enzymes in fatty acid synthesis.	Thioguanine	7-9	solute carrier family 10, member 2	Mus musculus	33-40
21465165-9	2011	The CAD patients carrying PON1-Arg-192 genotype (QR + RR) had lower plasma HDL-C level (P = 0.019) and higher plasma LDL-C(P = 0.01) and TG(P = 0.05).	Thioguanine	137-139	paraoxonase 1	Homo sapiens	26-30
22004541-1	2011	BACKGROUND: The triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been advocated as a simple clinical indicator of insulin resistance.	Thioguanine	76-78	insulin	Homo sapiens	139-146
21846719-6	2011	Insulin-stimulated phosphorylation of insulin receptor substrate-1 (IRS-1) and -2, and Akt was significantly attenuated in liver, but not in skeletal muscle, of L-iNOS-Tg mice relative to WT mice without changes in insulin receptor phosphorylation.	Thioguanine	168-170	insulin receptor substrate 1	Mus musculus	38-66
21846719-6	2011	Insulin-stimulated phosphorylation of insulin receptor substrate-1 (IRS-1) and -2, and Akt was significantly attenuated in liver, but not in skeletal muscle, of L-iNOS-Tg mice relative to WT mice without changes in insulin receptor phosphorylation.	Thioguanine	168-170	insulin receptor substrate 1	Mus musculus	68-81
21846719-6	2011	Insulin-stimulated phosphorylation of insulin receptor substrate-1 (IRS-1) and -2, and Akt was significantly attenuated in liver, but not in skeletal muscle, of L-iNOS-Tg mice relative to WT mice without changes in insulin receptor phosphorylation.	Thioguanine	168-170	thymoma viral proto-oncogene 1	Mus musculus	87-90
21846719-6	2011	Insulin-stimulated phosphorylation of insulin receptor substrate-1 (IRS-1) and -2, and Akt was significantly attenuated in liver, but not in skeletal muscle, of L-iNOS-Tg mice relative to WT mice without changes in insulin receptor phosphorylation.	Thioguanine	168-170	nitric oxide synthase 2, inducible	Mus musculus	163-167
21846719-6	2011	Insulin-stimulated phosphorylation of insulin receptor substrate-1 (IRS-1) and -2, and Akt was significantly attenuated in liver, but not in skeletal muscle, of L-iNOS-Tg mice relative to WT mice without changes in insulin receptor phosphorylation.	Thioguanine	168-170	insulin receptor	Mus musculus	38-54
21803983-6	2011	Genetic upregulation of the Keap1/Nrf2/ARE pathway, a major cellular regulator of the expression of a network of cytoprotective genes, reduces the incorporation of 6-thioguanine in DNA of both skin and liver following treatment with azathioprine.	Thioguanine	164-177	kelch like ECH associated protein 1	Homo sapiens	28-33
21803983-6	2011	Genetic upregulation of the Keap1/Nrf2/ARE pathway, a major cellular regulator of the expression of a network of cytoprotective genes, reduces the incorporation of 6-thioguanine in DNA of both skin and liver following treatment with azathioprine.	Thioguanine	164-177	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
21629041-5	2011	RESULTS: Differences in AGT plasma levels were associated with 2 polymorphisms: T-20G, TT = 25.3 +- 8.3 versus TG + GG = 21.6 +- 8.8 mug/mL; P = 0.008 and C3389T (T174M), CC = 25.8 +- 9.9 versus TC + TT = 20.5 +- 5.4 mug/mL; P = 0.0002.	Thioguanine	111-113	angiotensinogen	Homo sapiens	24-27
21914076-7	2011	Multivariate analysis also identified IL-28B genotype GG+TG (OR 14.1, P = 0.021) and alpha-fetoprotein &gt;30 (OR 5.4, P = 0.031) as independent predictors of null response.	Thioguanine	57-59	interferon lambda 3	Homo sapiens	38-44
21798277-5	2011	The resistance to 6-thioguanine is caused by the mutations in the hypoxanthine-guanine phosphoribosyltransferase (Hprt) gene.	Thioguanine	18-31	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	66-112
21798277-5	2011	The resistance to 6-thioguanine is caused by the mutations in the hypoxanthine-guanine phosphoribosyltransferase (Hprt) gene.	Thioguanine	18-31	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	114-118
21798277-6	2011	The molecular analysis of the coding region of Hprt gene showed a deletion of the entire exon 8 in DiMeDBC-induced 6-TG(r) mutants, while no changes in the nucleotide sequences were identified in 6-TG(r) mutants produced by DBC and N-MeDBC.	Thioguanine	115-119	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	47-51
21725623-12	2011	The combination of IL-10 and fondaparinux effects demonstrated that IL-10: (i) potentiates the inhibitory effect of fondaparinux on TG by 10-30%, and (ii) dramatically modifies fondaparinux IC50 for each TG parameter.	Thioguanine	132-134	interleukin 10	Homo sapiens	68-73
21923231-1	2011	IL-6 is believed to mediate the elevation in plasma TG and VLDL lipids in patients with sepsis.	Thioguanine	52-54	interleukin 6	Homo sapiens	0-4
21868511-0	2011	6-Thioguanine inhibition of parathyroid hormone-related protein expression is mediated by GLI2.	Thioguanine	0-13	parathyroid hormone like hormone	Homo sapiens	28-63
21868511-0	2011	6-Thioguanine inhibition of parathyroid hormone-related protein expression is mediated by GLI2.	Thioguanine	0-13	GLI family zinc finger 2	Homo sapiens	90-94
21868511-2	2011	The guanosine nucleotide 6-thioguanine (6-TG) inhibits PTHrP expression and blocks osteolytic bone destruction in mice inoculated with bone metastatic cells; however, the mechanism by which 6-TG inhibits PTHrP remains unclear.	Thioguanine	25-38	parathyroid hormone-like peptide	Mus musculus	55-60
21868511-2	2011	The guanosine nucleotide 6-thioguanine (6-TG) inhibits PTHrP expression and blocks osteolytic bone destruction in mice inoculated with bone metastatic cells; however, the mechanism by which 6-TG inhibits PTHrP remains unclear.	Thioguanine	25-38	parathyroid hormone-like peptide	Mus musculus	204-209
21868511-2	2011	The guanosine nucleotide 6-thioguanine (6-TG) inhibits PTHrP expression and blocks osteolytic bone destruction in mice inoculated with bone metastatic cells; however, the mechanism by which 6-TG inhibits PTHrP remains unclear.	Thioguanine	40-44	parathyroid hormone-like peptide	Mus musculus	55-60
21868511-2	2011	The guanosine nucleotide 6-thioguanine (6-TG) inhibits PTHrP expression and blocks osteolytic bone destruction in mice inoculated with bone metastatic cells; however, the mechanism by which 6-TG inhibits PTHrP remains unclear.	Thioguanine	40-44	parathyroid hormone-like peptide	Mus musculus	204-209
21868511-2	2011	The guanosine nucleotide 6-thioguanine (6-TG) inhibits PTHrP expression and blocks osteolytic bone destruction in mice inoculated with bone metastatic cells; however, the mechanism by which 6-TG inhibits PTHrP remains unclear.	Thioguanine	190-194	parathyroid hormone-like peptide	Mus musculus	204-209
21868511-3	2011	We hypothesized that 6-TG inhibition of PTHrP is mediated through GLI2 signaling.	Thioguanine	21-25	parathyroid hormone like hormone	Homo sapiens	40-45
21868511-3	2011	We hypothesized that 6-TG inhibition of PTHrP is mediated through GLI2 signaling.	Thioguanine	21-25	GLI family zinc finger 2	Homo sapiens	66-70
21868511-6	2011	Additionally, 6-TG directly inhibited GLI2 promoter activity, and when cells were transfected with constitutively expressed GLI2, the inhibitory effect of 6-TG on PTHrP expression was abolished.	Thioguanine	14-18	GLI family zinc finger 2	Homo sapiens	38-42
21868511-6	2011	Additionally, 6-TG directly inhibited GLI2 promoter activity, and when cells were transfected with constitutively expressed GLI2, the inhibitory effect of 6-TG on PTHrP expression was abolished.	Thioguanine	14-18	parathyroid hormone like hormone	Homo sapiens	163-168
21868511-6	2011	Additionally, 6-TG directly inhibited GLI2 promoter activity, and when cells were transfected with constitutively expressed GLI2, the inhibitory effect of 6-TG on PTHrP expression was abolished.	Thioguanine	155-159	GLI family zinc finger 2	Homo sapiens	124-128
21868511-6	2011	Additionally, 6-TG directly inhibited GLI2 promoter activity, and when cells were transfected with constitutively expressed GLI2, the inhibitory effect of 6-TG on PTHrP expression was abolished.	Thioguanine	155-159	parathyroid hormone like hormone	Homo sapiens	163-168
21868511-7	2011	CONCLUSION: Taken together, these data indicate that 6-TG regulates PTHrP in part through GLI2 transcription, and therefore the clinical use of 6-TG or other guanosine nucleotides may be a viable therapeutic option in tumor types expressing elevated levels of GLI proteins.	Thioguanine	53-57	parathyroid hormone like hormone	Homo sapiens	68-73
21868511-7	2011	CONCLUSION: Taken together, these data indicate that 6-TG regulates PTHrP in part through GLI2 transcription, and therefore the clinical use of 6-TG or other guanosine nucleotides may be a viable therapeutic option in tumor types expressing elevated levels of GLI proteins.	Thioguanine	53-57	GLI family zinc finger 2	Homo sapiens	90-94
21868511-7	2011	CONCLUSION: Taken together, these data indicate that 6-TG regulates PTHrP in part through GLI2 transcription, and therefore the clinical use of 6-TG or other guanosine nucleotides may be a viable therapeutic option in tumor types expressing elevated levels of GLI proteins.	Thioguanine	144-148	parathyroid hormone like hormone	Homo sapiens	68-73
21596107-2	2011	The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner.	Thioguanine	61-63	transmembrane protein 132A	Rattus norvegicus	126-129
21609753-5	2011	RESULTS: Apelin-Tg mice inhibited HFD-induced obesity without altering food intake and exhibited increased oxygen consumption and body temperature compared to non-Tg controls.	Thioguanine	16-18	apelin	Mus musculus	9-15
21734060-5	2011	ASTX-fed apoE(-/-) mice had significantly lower plasma total cholesterol and TG concentrations than controls, but body weight and plasma alanine aminotransferase and aspartate aminotransferase did not differ between the groups.	Thioguanine	77-79	apolipoprotein E	Mus musculus	9-13
21950931-2	2011	We show that strong TPEF + SHG + THG signals can be obtained in fixed samples stained with hematoxylin and eosin (H&amp;E) stored for a very long time, and that H&amp;E staining enhanced the THG signal.	Thioguanine	33-36	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	20-24
21950931-2	2011	We show that strong TPEF + SHG + THG signals can be obtained in fixed samples stained with hematoxylin and eosin (H&amp;E) stored for a very long time, and that H&amp;E staining enhanced the THG signal.	Thioguanine	191-194	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	20-24
21628634-1	2011	Mice fed a mixture of CLA containing t10,c12-CLA lose fat mass and develop hyperinsulinemia and hepatic steatosis due to an accumulation of TG and cholesterol.	Thioguanine	140-142	clasper	Mus musculus	22-25
21855698-4	2011	The combination of increased hepatic VLDL secretion with impaired LPL-mediated TG clearance explains the hypertriglyceridemia phenotype of the metabolic syndrome.	Thioguanine	79-81	lipoprotein lipase	Homo sapiens	66-69
21723207-7	2011	Cells defective in the FA pathway or other factors involved in ICL processing, such as XPF and DNA Polzeta, are all hypersensitive to killing by 6-TG/UVA-consistent with a significant contribution of photochemical ICLs to the cytotoxicity of this treatment.	Thioguanine	145-149	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	87-90
21730284-1	2011	OBJECTIVE: We evaluated whether the triglyceride-to-HDL cholesterol (TG/HDL-C) ratio is associated with insulin resistance (IR) in a large multiethnic cohort of obese youths.	Thioguanine	69-71	insulin	Homo sapiens	104-111
21606464-6	2011	This initial raise in VLDL, caused by competition between rHDL and VLDL for LPL-mediated TG hydrolysis, was thus prevented by CETP.	Thioguanine	89-91	CD320 antigen	Mus musculus	22-26
21606464-6	2011	This initial raise in VLDL, caused by competition between rHDL and VLDL for LPL-mediated TG hydrolysis, was thus prevented by CETP.	Thioguanine	89-91	CD320 antigen	Mus musculus	67-71
21606464-6	2011	This initial raise in VLDL, caused by competition between rHDL and VLDL for LPL-mediated TG hydrolysis, was thus prevented by CETP.	Thioguanine	89-91	lipoprotein lipase	Mus musculus	76-79
21606464-6	2011	This initial raise in VLDL, caused by competition between rHDL and VLDL for LPL-mediated TG hydrolysis, was thus prevented by CETP.	Thioguanine	89-91	cholesteryl ester transfer protein	Homo sapiens	126-130
21606464-8	2011	This secondary raise in VLDL was due to increased hepatic VLDL-TG production.	Thioguanine	63-65	CD320 antigen	Mus musculus	24-28
21606464-8	2011	This secondary raise in VLDL was due to increased hepatic VLDL-TG production.	Thioguanine	63-65	CD320 antigen	Mus musculus	58-62
21628634-1	2011	Mice fed a mixture of CLA containing t10,c12-CLA lose fat mass and develop hyperinsulinemia and hepatic steatosis due to an accumulation of TG and cholesterol.	Thioguanine	140-142	clasper	Mus musculus	45-48
21640727-9	2011	Glycolytic end products (lactate and alanine) were 38% higher in TG-ssTnI than NTG at 2 min and 27% higher at 5 min.	Thioguanine	65-67	troponin I, skeletal, slow 1	Mus musculus	68-73
21593353-2	2011	Genetic variants in the FADS1-FADS2 gene cluster are associated with changes in plasma concentrations of PUFA, HDL- and LDL-cholesterol, and TG.	Thioguanine	141-143	fatty acid desaturase 1	Homo sapiens	24-29
21447566-10	2011	dPA : dAA and TG(ECHO) were independent predictors of mPAP.	Thioguanine	14-16	phospholipid phosphatase 1	Mus musculus	54-58
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	77-90	solute carrier family 28 member 3	Homo sapiens	190-228
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	77-90	solute carrier family 28 member 3	Homo sapiens	230-234
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	77-90	solute carrier family 29 member 2	Homo sapiens	240-278
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	77-90	solute carrier family 29 member 2	Homo sapiens	280-284
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	92-96	solute carrier family 28 member 3	Homo sapiens	190-228
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	92-96	solute carrier family 28 member 3	Homo sapiens	230-234
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	92-96	solute carrier family 29 member 2	Homo sapiens	240-278
21723252-1	2011	Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2).	Thioguanine	92-96	solute carrier family 29 member 2	Homo sapiens	280-284
21723252-5	2011	In addition, expression of the mRNA for a specialized DNA polymerase, human terminal transferase encoded by the terminal deoxynucleotidyl transferase (DNTT) gene, was 122- and 93-fold higher in 6-TG- and 6-MP-resistant cells, respectively.	Thioguanine	194-198	DNA nucleotidylexotransferase	Homo sapiens	76-96
21723252-5	2011	In addition, expression of the mRNA for a specialized DNA polymerase, human terminal transferase encoded by the terminal deoxynucleotidyl transferase (DNTT) gene, was 122- and 93-fold higher in 6-TG- and 6-MP-resistant cells, respectively.	Thioguanine	194-198	DNA nucleotidylexotransferase	Homo sapiens	151-155
21593353-7	2011	The associations between FADS1 rs174546 and concentrations of PUFA, TG, cholesterol, and lipoproteins were not affected by dietary LA intake (all P-interaction &gt; 0.05).	Thioguanine	68-70	fatty acid desaturase 1	Homo sapiens	25-30
21593353-2	2011	Genetic variants in the FADS1-FADS2 gene cluster are associated with changes in plasma concentrations of PUFA, HDL- and LDL-cholesterol, and TG.	Thioguanine	141-143	fatty acid desaturase 2	Homo sapiens	30-35
21781592-6	2011	FER(HDL) was positively correlated with TG (r = 0.647, P &lt; 0.001), LDLb-C(r = 0.441, P &lt; 0.001) and negatively correlated with HDL-C (r = -0.708, P &lt; 0.001) and HDL(2)-C (r = -0.748, P &lt; 0.001).	Thioguanine	40-42	FER tyrosine kinase	Homo sapiens	0-8
20883102-1	2011	OBJECTIVE: Apolipoprotein A5 (APOA5) gene variants have been shown to be associated with elevated TG levels; the T-1131C (rs662799) variant has been reported to confer risk for the metabolic syndrome in adult populations.	Thioguanine	98-100	apolipoprotein A5	Homo sapiens	11-28
20883102-1	2011	OBJECTIVE: Apolipoprotein A5 (APOA5) gene variants have been shown to be associated with elevated TG levels; the T-1131C (rs662799) variant has been reported to confer risk for the metabolic syndrome in adult populations.	Thioguanine	98-100	apolipoprotein A5	Homo sapiens	30-35
21525253-7	2011	The plasma TG concentration was positively correlated with the plasma insulin concentration (r = 0.40; P &lt; 0.001) and negatively correlated with HDL-C (r = -0.47; P &lt; 0.001) and plasma 18:0 (r = -0.24; P &lt; 0.01).	Thioguanine	11-13	insulin	Homo sapiens	70-77
21609439-15	2011	In CETPd the regression multivariate analysis (model A) showed that CETP was largely and negatively predicted by VLDL-C lipemia (R2 = 92%) and much less by TG, LDL-C, ApoAI, phospholipids and non-HDL-C. CETP (model B) influenced mainly the increment in ApoB-100 containing lipoproteins (R2 = 85% negatively) and phospholipids (R2 = 13%), at the 6(th)h point.	Thioguanine	156-158	cholesteryl ester transfer protein	Homo sapiens	68-72
21536883-6	2011	We identified a pharmacologic CDK2/cyclin E inhibitor, R-roscovitine (seliciclib; CYC202), which specifically reversed corticotroph expansion in live Tg:Pomc-Pttg embryos.	Thioguanine	150-152	cyclin-dependent kinase 2	Mus musculus	30-34
21536883-6	2011	We identified a pharmacologic CDK2/cyclin E inhibitor, R-roscovitine (seliciclib; CYC202), which specifically reversed corticotroph expansion in live Tg:Pomc-Pttg embryos.	Thioguanine	150-152	pro-opiomelanocortin-alpha	Mus musculus	153-157
21442376-7	2011	We observed an important improvement in insulin resistance and metabolic syndrome, with a significant reduction of the TG/HDL ratio from 5.75 to 4.36 (p &lt; 0.001) and 42.6% of the patients presenting a TG/HDL ratio lower than 3.5 at the end of the study.	Thioguanine	119-121	insulin	Homo sapiens	40-47
21442376-7	2011	We observed an important improvement in insulin resistance and metabolic syndrome, with a significant reduction of the TG/HDL ratio from 5.75 to 4.36 (p &lt; 0.001) and 42.6% of the patients presenting a TG/HDL ratio lower than 3.5 at the end of the study.	Thioguanine	204-206	insulin	Homo sapiens	40-47
21600523-7	2011	For TG &gt;= 250 mg/dL, the corresponding LDL-C was generally lower than that for triglycerides 150-250 mg/dL, except in the cases with fenofibrate in the treatment.	Thioguanine	4-6	component of oligomeric golgi complex 2	Homo sapiens	42-47
21781592-6	2011	FER(HDL) was positively correlated with TG (r = 0.647, P &lt; 0.001), LDLb-C(r = 0.441, P &lt; 0.001) and negatively correlated with HDL-C (r = -0.708, P &lt; 0.001) and HDL(2)-C (r = -0.748, P &lt; 0.001).	Thioguanine	40-42	FER tyrosine kinase	Homo sapiens	4-7
20891012-4	2011	TG loaded in elastic (1 mol% NaC) anionic niosomes gave the highest cell viability both in HT-29 (92.32 +- 3.82%) and KB cells (96.62 +- 5.96%), the highest cumulative amounts (62.75 +- 2.68 mug/cm(2) ) and fluxes (10.46 +- 3.45 mug/cm(2) h) in receiving chamber in rat skin transdermal study by Franz diffusion cells.	Thioguanine	0-2	X-linked Kx blood group	Homo sapiens	29-32
21223971-4	2011	We created an inducible, cardiomyocyte-restricted STAT3 deficient mouse (MCM TG:STAT3(flox/flox)) by interbreeding STAT3(flox/flox) mice and tamoxifen-inducible MCM TG mice.	Thioguanine	77-79	signal transducer and activator of transcription 3	Mus musculus	50-55
21223971-4	2011	We created an inducible, cardiomyocyte-restricted STAT3 deficient mouse (MCM TG:STAT3(flox/flox)) by interbreeding STAT3(flox/flox) mice and tamoxifen-inducible MCM TG mice.	Thioguanine	165-167	signal transducer and activator of transcription 3	Mus musculus	50-55
21383199-4	2011	We examined the effects of miR-155 overexpression and proinflammatory environment on the frequency of spontaneous hypoxanthine phosphoribosyltransferase (HPRT) mutations that can be detected based on the resistance to 6-thioguanine.	Thioguanine	218-231	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	114-152
20153614-10	2011	CONCLUSIONS: Elevated plasma adiponectin concentration is associated with a favourable VLDL-TG metabolism.	Thioguanine	92-94	adiponectin, C1Q and collagen domain containing	Homo sapiens	29-40
21383199-4	2011	We examined the effects of miR-155 overexpression and proinflammatory environment on the frequency of spontaneous hypoxanthine phosphoribosyltransferase (HPRT) mutations that can be detected based on the resistance to 6-thioguanine.	Thioguanine	218-231	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	154-158
21239472-0	2011	6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1.	Thioguanine	0-13	DNA methyltransferase 1	Homo sapiens	145-150
21282358-4	2011	Because the growth of MTAP-deleted tumor cells is dependent on DNPS or hypoxanthine salvage, we would predict such cells to show differential sensitivity to 6-MP and 6-TG.	Thioguanine	166-170	methylthioadenosine phosphorylase	Homo sapiens	22-26
21143375-11	2011	Tissue factor pathway inhibitor (TFPI) seems to be an important determinant of TG in AMI and healthy persons.	Thioguanine	79-81	tissue factor pathway inhibitor	Homo sapiens	0-31
21143375-11	2011	Tissue factor pathway inhibitor (TFPI) seems to be an important determinant of TG in AMI and healthy persons.	Thioguanine	79-81	tissue factor pathway inhibitor	Homo sapiens	33-37
21182840-0	2011	In vivo 6-thioguanine-resistant T cells from melanoma patients have public TCR and share TCR beta amino acid sequences with melanoma-reactive T cells.	Thioguanine	8-21	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	75-78
21182840-0	2011	In vivo 6-thioguanine-resistant T cells from melanoma patients have public TCR and share TCR beta amino acid sequences with melanoma-reactive T cells.	Thioguanine	8-21	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	89-92
21205838-0	2011	The homologous recombination protein RAD51D mediates the processing of 6-thioguanine lesions downstream of mismatch repair.	Thioguanine	71-84	RAD51 paralog D	Homo sapiens	37-43
21205838-7	2011	Furthermore, 6-thioG induces chromosome aberrations in the Rad51d-deficient cells.	Thioguanine	13-20	RAD51 paralog D	Homo sapiens	59-65
21205838-8	2011	Interestingly, Rad51d-deficient cells show a striking increase in the frequency of triradial and quadriradial chromosomes in response to 6-thioG therapy.	Thioguanine	137-144	RAD51 paralog D	Homo sapiens	15-21
21205838-5	2011	In this study, we demonstrate that cells deficient in RAD51D (a RAD51 paralogue) are extremely sensitive to 6-thioG.	Thioguanine	108-115	RAD51 paralog D	Homo sapiens	54-60
21205838-6	2011	This sensitivity is almost completely rescued by the deletion of Mlh1, which suggests that HR is involved in the repair of the 6-thioG-induced recombinogenic lesions generated by MMR.	Thioguanine	127-134	mutL homolog 1	Homo sapiens	65-69
21144556-11	2011	Elevated FVIII levels seem to favor intrinsic tenase formation and antagonize fondaparinux because anti-FIXa aptamer added to fondaparinux effectively attenuated TG.	Thioguanine	162-164	coagulation factor VIII	Homo sapiens	9-14
20858686-2	2011	The objective was to compare basal and insulin mediated VLDL-TG kinetics, oxidation, and adipose tissue storage in type 2 diabetic and healthy (nondiabetic) men.	Thioguanine	61-63	insulin	Homo sapiens	39-46
20858853-3	2011	Plasma and whole blood coagulation assays, the latter measured by thromboelastography, demonstrated development of coagulopathies in LPS-treated mice, which were more severe in the case of the doubly deficient TF(-/-)hTF(tg)/PC(-/-)PC(tg4) mice, mainly reflecting earlier signs of disseminated intravascular coagulation in this latter cohort.	Thioguanine	221-223	coagulation factor III	Mus musculus	210-212
20858853-5	2011	We conclude that whereas coagulopathies are more exacerbated in LPS-treated TF(-/-)hTF(tg)/PC(-/-)PC(tg4) mice, the lowering of TF levels in mice with an accompanying severe PC deficiency confers protection against death compared with mice with a single severe PC deficiency.	Thioguanine	87-89	coagulation factor III	Mus musculus	76-78
20858853-5	2011	We conclude that whereas coagulopathies are more exacerbated in LPS-treated TF(-/-)hTF(tg)/PC(-/-)PC(tg4) mice, the lowering of TF levels in mice with an accompanying severe PC deficiency confers protection against death compared with mice with a single severe PC deficiency.	Thioguanine	87-89	coagulation factor III	Mus musculus	84-86
22292622-8	2011	Overall, significant associations between the MDM2 SNP309T&gt;G and HNSCC risk for TG vs. TT model and the dominant model (TG+GG vs. TT) were observed (OR=0.82, 95%CI=0.70-0.96 and OR=0.83, 95%CI=0.71-0.96, respectively).	Thioguanine	83-85	transformed mouse 3T3 cell double minute 2	Mus musculus	46-50
22292622-8	2011	Overall, significant associations between the MDM2 SNP309T&gt;G and HNSCC risk for TG vs. TT model and the dominant model (TG+GG vs. TT) were observed (OR=0.82, 95%CI=0.70-0.96 and OR=0.83, 95%CI=0.71-0.96, respectively).	Thioguanine	123-125	transformed mouse 3T3 cell double minute 2	Mus musculus	46-50
21389639-3	2011	We measured food intake, body weight (including body fat weight) and plasma corticosterone levels in CRH-Tg and their wild-type littermates (WT) at 6 and 14 weeks old.	Thioguanine	105-107	corticotropin releasing hormone	Mus musculus	101-104
22216194-0	2011	Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure.	Thioguanine	105-116	thiopurine S-methyltransferase	Homo sapiens	0-28
20971921-7	2011	Upon store depletion with Tg, STIM2 aggregates and interacts selectively with Orai2.	Thioguanine	26-28	stromal interaction molecule 2	Mus musculus	30-35
20971921-7	2011	Upon store depletion with Tg, STIM2 aggregates and interacts selectively with Orai2.	Thioguanine	26-28	ORAI calcium release-activated calcium modulator 2	Mus musculus	78-83
22188706-5	2011	LDL-C/apoB was significantly lower in patients with serum TG &gt;= 150 mg/dL than in those with serum TG &lt; 150 mg/dL, and in patients with serum HDL-C &lt; 40 mg/dL than in those with serum HDL-C &gt;= 40 mg/dL (1.06 versus 1.18, P = 0.012; 1.08 versus 1.22, P = 0.0023).	Thioguanine	58-60	apolipoprotein B	Homo sapiens	6-10
22188706-5	2011	LDL-C/apoB was significantly lower in patients with serum TG &gt;= 150 mg/dL than in those with serum TG &lt; 150 mg/dL, and in patients with serum HDL-C &lt; 40 mg/dL than in those with serum HDL-C &gt;= 40 mg/dL (1.06 versus 1.18, P = 0.012; 1.08 versus 1.22, P = 0.0023).	Thioguanine	102-104	apolipoprotein B	Homo sapiens	6-10
21750375-7	2011	We also found significantly reduced PreP activity in the mitochondrial matrix of AD transgenic mouse brains (Tg mAbetaPP and Tg mAbetaPP/ABAD) when compared to non-transgenic aged-matched mice.	Thioguanine	109-111	prolyl endopeptidase	Mus musculus	36-40
21750375-7	2011	We also found significantly reduced PreP activity in the mitochondrial matrix of AD transgenic mouse brains (Tg mAbetaPP and Tg mAbetaPP/ABAD) when compared to non-transgenic aged-matched mice.	Thioguanine	125-127	prolyl endopeptidase	Mus musculus	36-40
22216194-5	2011	We found that TG induced cytotoxicity in a dose-dependent manner in Tpmt(+/+), Tpmt(+/-) and Tpmt(-/-) primary mouse astrocytes and that a low Tpmt phenotype predicted significantly higher sensitivity to TG than did a high Tpmt phenotype.	Thioguanine	14-16	thiopurine methyltransferase	Mus musculus	68-72
22216194-5	2011	We found that TG induced cytotoxicity in a dose-dependent manner in Tpmt(+/+), Tpmt(+/-) and Tpmt(-/-) primary mouse astrocytes and that a low Tpmt phenotype predicted significantly higher sensitivity to TG than did a high Tpmt phenotype.	Thioguanine	14-16	thiopurine methyltransferase	Mus musculus	79-83
22216194-5	2011	We found that TG induced cytotoxicity in a dose-dependent manner in Tpmt(+/+), Tpmt(+/-) and Tpmt(-/-) primary mouse astrocytes and that a low Tpmt phenotype predicted significantly higher sensitivity to TG than did a high Tpmt phenotype.	Thioguanine	14-16	thiopurine methyltransferase	Mus musculus	79-83
22216194-5	2011	We found that TG induced cytotoxicity in a dose-dependent manner in Tpmt(+/+), Tpmt(+/-) and Tpmt(-/-) primary mouse astrocytes and that a low Tpmt phenotype predicted significantly higher sensitivity to TG than did a high Tpmt phenotype.	Thioguanine	14-16	thiopurine methyltransferase	Mus musculus	79-83
22216194-5	2011	We found that TG induced cytotoxicity in a dose-dependent manner in Tpmt(+/+), Tpmt(+/-) and Tpmt(-/-) primary mouse astrocytes and that a low Tpmt phenotype predicted significantly higher sensitivity to TG than did a high Tpmt phenotype.	Thioguanine	14-16	thiopurine methyltransferase	Mus musculus	79-83
22216194-7	2011	More interestingly, we found that Tpmt(+/-) astrocytes had the highest degree of cytotoxicity and genotoxicity (i.e., IC(50), SSBs and DSBs) after TG exposure.	Thioguanine	147-149	thiopurine S-methyltransferase	Homo sapiens	34-38
21209828-5	2010	In these subjects, a common CNR1 haplotype (H3, frequency 21.1%) is associated with fasting TG and HDL cholesterol levels (p = 0.031 for logTG; p = 0.038 for HDL-C; p = 0.00376 for log[TG/HDL-C]).	Thioguanine	92-94	cannabinoid receptor 1	Homo sapiens	28-32
21637823-6	2011	Serum levels of TNF-alpha and Il-6 were elevated in TG.	Thioguanine	52-54	tumor necrosis factor	Mus musculus	16-25
21637823-6	2011	Serum levels of TNF-alpha and Il-6 were elevated in TG.	Thioguanine	52-54	interleukin 6	Mus musculus	30-34
21042235-5	2010	CD68+ cells more than 12 in the most inflamed glomerulus were strongly associated with TG, donor-specific antibody (DSA), and C4d staining.	Thioguanine	87-89	CD68 molecule	Homo sapiens	0-4
21151976-5	2010	Approximately 2% of the G418 resistant colonies also tolerated selection with 6-thioguanine, indicating inactivation of the hprt gene.	Thioguanine	78-91	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	124-128
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Thioguanine	0-2	proliferating cell nuclear antigen	Rattus norvegicus	221-255
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Thioguanine	0-2	proliferating cell nuclear antigen	Rattus norvegicus	257-261
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Thioguanine	161-163	proliferating cell nuclear antigen	Rattus norvegicus	221-255
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Thioguanine	161-163	proliferating cell nuclear antigen	Rattus norvegicus	257-261
20961717-9	2010	Mean plasma concentrations of glucose and insulin were significantly (P&lt;0.05) higher in the TG than in the CG on almost all days during each treatment period.	Thioguanine	95-97	insulin	Capra hircus	42-49
21143812-5	2010	Moreover, dinucleotides CA/TG are remarkably important in distinguishing target sites of H2A.Z-only nucleosomes with those of H3.3-containing (both H3.3-only and double variant) nucleosomes.	Thioguanine	27-29	H2A.Z variant histone 1	Homo sapiens	89-94
21059996-5	2010	In WT DOCA-salt and hph-1 mice, EPCs were significantly decreased with impaired angiogenesis and adhesion, which were restored in Tg-GCH DOCA-salt mice.	Thioguanine	130-132	hyperphenylalaninemia 1	Mus musculus	20-25
20815776-6	2010	It is shown that palmitate caused induction of iNOS resulting in increased nitrite/nitrate concentration and slight increase in TG content.	Thioguanine	128-130	nitric oxide synthase 2	Rattus norvegicus	47-51
21059996-6	2010	Superoxide (O2-) and nitric oxide (NO) levels in EPCs were elevated and reduced, respectively, in WT DOCA-salt and hph-1 mice; both were rescued in Tg-GCH DOCA-salt mice.	Thioguanine	148-150	hyperphenylalaninemia 1	Mus musculus	115-120
20932032-6	2010	TG accumulation and lipogenic gene expression, including the expression of genes for fatty acid synthase (FAS), acetyl-coenzyme A carboxylase (ACC), and malic enzyme, were significantly lower in the livers of mice that received TG-CLA as compared to FFA-CLA.	Thioguanine	0-2	fatty acid synthase	Mus musculus	85-104
20864418-7	2010	Furthermore, cells expressing these MLH1 mutations exhibited resistance to the MMR-dependent cytotoxic effect of 6-thioguanine (6-TG).	Thioguanine	113-126	mutL homolog 1	Homo sapiens	36-40
20864418-7	2010	Furthermore, cells expressing these MLH1 mutations exhibited resistance to the MMR-dependent cytotoxic effect of 6-thioguanine (6-TG).	Thioguanine	128-132	mutL homolog 1	Homo sapiens	36-40
20699090-10	2010	There is an inverse relationship between bile acid fluxes and pool size and VLDL production and SHP (small heterodimer partner) and FXR are the link between BAs and TG metabolism.	Thioguanine	165-167	nuclear receptor subfamily 0 group B member 2	Homo sapiens	96-99
20699090-10	2010	There is an inverse relationship between bile acid fluxes and pool size and VLDL production and SHP (small heterodimer partner) and FXR are the link between BAs and TG metabolism.	Thioguanine	165-167	nuclear receptor subfamily 0 group B member 2	Homo sapiens	101-126
20699090-10	2010	There is an inverse relationship between bile acid fluxes and pool size and VLDL production and SHP (small heterodimer partner) and FXR are the link between BAs and TG metabolism.	Thioguanine	165-167	nuclear receptor subfamily 1 group H member 4	Homo sapiens	132-135
20699090-24	2010	There is evidence that the gallbladder in HTG is less sensitive to CCK and that this sensitivity improves after reversal of high serum TG levels by use of TG lowering agents.	Thioguanine	43-45	cholecystokinin	Homo sapiens	67-70
20932032-6	2010	TG accumulation and lipogenic gene expression, including the expression of genes for fatty acid synthase (FAS), acetyl-coenzyme A carboxylase (ACC), and malic enzyme, were significantly lower in the livers of mice that received TG-CLA as compared to FFA-CLA.	Thioguanine	0-2	fatty acid synthase	Mus musculus	106-109
20876452-7	2010	Angiotensin II contractions were less sensitive (10(-8) mol/L) and responsive (14%) in SOD1-tg but more sensitive (10(-13) mol/L) and responsive (89%) in SOD1-ko mice.	Thioguanine	92-94	superoxide dismutase 1, soluble	Mus musculus	87-91
20977448-5	2010	Combination of APCC and FVIII showed a synergistic effect in eliciting TG (P&lt;0 005) for four FVIII products.	Thioguanine	71-73	coagulation factor VIII	Homo sapiens	24-29
20977448-5	2010	Combination of APCC and FVIII showed a synergistic effect in eliciting TG (P&lt;0 005) for four FVIII products.	Thioguanine	71-73	coagulation factor VIII	Homo sapiens	96-101
20521035-2	2010	PURPOSE: thiopurine methyltransferase TPMT catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine.	Thioguanine	117-130	thiopurine S-methyltransferase	Homo sapiens	9-37
20881512-2	2010	TPMT is involved in the detoxification and activation of thiopurines such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	95-108	thiopurine S-methyltransferase	Homo sapiens	0-4
20950490-11	2010	The protective effect of increased apoA-I levels against the reduction of HDL(2b) caused by elevated TG concentration.	Thioguanine	101-103	apolipoprotein A1	Homo sapiens	35-41
20701589-2	2010	We studied TBC1D1 phosphorylation on three predicted AMPK (AMP-activated protein kinase) phosphorylation sites (Ser231, Ser660 and Ser700) and one predicted Akt phosphorylation site (Thr590) in control mice, AMPKalpha2 inactive transgenic mice (AMPKalpha2i TG) and Akt2-knockout mice (Akt2 KO).	Thioguanine	257-259	TBC1 domain family, member 1	Mus musculus	11-17
20701589-5	2010	Basal and contraction-stimulated TBC1D1 Ser231, Ser660 and Ser700 phosphorylation were greatly reduced in AMPKalpha2i TG mice, although contraction still elicited a small increase in phosphorylation.	Thioguanine	118-120	TBC1 domain family, member 1	Mus musculus	33-39
20701589-5	2010	Basal and contraction-stimulated TBC1D1 Ser231, Ser660 and Ser700 phosphorylation were greatly reduced in AMPKalpha2i TG mice, although contraction still elicited a small increase in phosphorylation.	Thioguanine	118-120	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	106-116
20977771-15	2010	CONCLUSIONS: The differences in serum TC, TG, LDL-C and ApoB levels between the two ethnic groups might partly result from different genotypic and allelic frequencies of the MTHFR C677T or different MTHFR gene-enviromental interactions.	Thioguanine	42-44	methylenetetrahydrofolate reductase	Homo sapiens	174-179
20521035-2	2010	PURPOSE: thiopurine methyltransferase TPMT catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine.	Thioguanine	117-130	thiopurine S-methyltransferase	Homo sapiens	38-42
19880163-2	2010	No studies have investigated the impact of postprandial lipemia on TF-induced TG.	Thioguanine	78-80	coagulation factor III, tissue factor	Homo sapiens	67-69
20600102-7	2010	Phlorizin, a specific SGLT1 inhibitor, attenuated cardiac glucose uptake in TG(T400N) mice by approximately 40%, but not in WT mice.	Thioguanine	76-78	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	22-27
19880163-8	2010	CONCLUSIONS: MI-patients had elevated postprandial lipemia and retained their ability for TF-induced TG in plasma ex vivo in the postprandial phase, whereas the capacity gradually decreased in healthy individuals.	Thioguanine	101-103	coagulation factor III, tissue factor	Homo sapiens	90-92
20737607-7	2010	In addition, adiponectin correlated with TG (r = -0.277) and leptin (r = -0.381).	Thioguanine	41-43	adiponectin, C1Q and collagen domain containing	Homo sapiens	13-24
20737607-11	2010	From blood lipids, only TG correlated significantly with adiponectin.	Thioguanine	24-26	adiponectin, C1Q and collagen domain containing	Homo sapiens	57-68
20737607-1	2010	The aim of this study was to investigate the possible relationships between adiponectin and leptin with blood lipids (CHOL, HDL-C, LDL-C, and TG) in physically active postmenopausal women.	Thioguanine	142-144	adiponectin, C1Q and collagen domain containing	Homo sapiens	76-87
20639222-7	2010	BH(4) decreased aortic superoxide production, partially restored bioavailable nitric oxide in aortas of ANG II-treated Tg(SMCnox1) mice, and significantly improved endothelium-dependent relaxation in these mice.	Thioguanine	119-121	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	104-110
20639222-9	2010	Pretreatment of mouse aortas with the eNOS inhibitor N(G)-nitro-L-arginine methyl ester decreased ANG II-induced superoxide production in Tg(SMCnox1) mice compared with wild-type mice, indicating that uncoupled eNOS is also a significant source of increased superoxide in transgenic mice.	Thioguanine	138-140	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	98-104
20615262-1	2010	BACKGROUND: To evaluate the relationship between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and HDL subclass distribution and to further examine and discuss the potential impact of LDL-C and HDL-C together with TG on HDL subclass metabolism.	Thioguanine	267-269	component of oligomeric golgi complex 2	Homo sapiens	53-88
19733470-6	2010	Despite comparable insulin resistance, fasting lipids, adipokines and dietary habits, MTP GG genotype had significantly more severe beta-cell dysfunction; higher plasma Tg, FFA, intestinal and hepatic very low-density lipoprotein 1 subfractions and oxLDL responses and deeper HDL-C fall than GT/TT carriers in patients and controls.	Thioguanine	169-171	microsomal triglyceride transfer protein	Homo sapiens	86-89
20510883-7	2010	In summary, distinct changes of MTP expression, in correlation with hepatic TG secretion, underlie the opposite responses of plasma TG levels to high-fat diets in hamsters and mice.	Thioguanine	76-78	lysosomal-associated protein transmembrane 4A	Mus musculus	32-35
20530733-12	2010	Also, GLP-1 treatment reinforced the inhibitory action of insulin on VLDL-TG production.	Thioguanine	74-76	glucagon	Mus musculus	6-11
20530733-12	2010	Also, GLP-1 treatment reinforced the inhibitory action of insulin on VLDL-TG production.	Thioguanine	74-76	insulin	Homo sapiens	58-65
20530733-13	2010	In conclusion, peripheral administration of GLP-1 reinforces the ability of insulin to suppress endogenous glucose and VLDL-TG production (but not lipolysis) and boosts its capacity to stimulate glucose disposal in high-fat-fed C57Bl/6 mice.	Thioguanine	124-126	glucagon	Mus musculus	44-49
20530733-13	2010	In conclusion, peripheral administration of GLP-1 reinforces the ability of insulin to suppress endogenous glucose and VLDL-TG production (but not lipolysis) and boosts its capacity to stimulate glucose disposal in high-fat-fed C57Bl/6 mice.	Thioguanine	124-126	insulin	Homo sapiens	76-83
20697940-5	2010	(2) MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group.	Thioguanine	47-50	matrix metallopeptidase 9	Homo sapiens	4-9
20697940-8	2010	CONCLUSION: THG can effectively lower ICP, down-regulate MMP-9 expression, promote the absorption: of cerebral hematoma and hydrocephalus, and improve the nerve function, showing a clinical effectiveness than conventional therapy.	Thioguanine	12-15	matrix metallopeptidase 9	Homo sapiens	57-62
20506532-4	2010	Since MTX is often used to generate high producing cell lines, we investigated the genomic mutation rates of the hypoxanthine-guanine phosphoribosyltransferase (HGPRT or HPRT) gene using a 6-thioguanine (6-TG) assay under various concentrations of MTX selection in CHO cells.	Thioguanine	189-202	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	113-159
20506532-4	2010	Since MTX is often used to generate high producing cell lines, we investigated the genomic mutation rates of the hypoxanthine-guanine phosphoribosyltransferase (HGPRT or HPRT) gene using a 6-thioguanine (6-TG) assay under various concentrations of MTX selection in CHO cells.	Thioguanine	189-202	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	161-166
20506532-4	2010	Since MTX is often used to generate high producing cell lines, we investigated the genomic mutation rates of the hypoxanthine-guanine phosphoribosyltransferase (HGPRT or HPRT) gene using a 6-thioguanine (6-TG) assay under various concentrations of MTX selection in CHO cells.	Thioguanine	189-202	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	170-174
20506532-4	2010	Since MTX is often used to generate high producing cell lines, we investigated the genomic mutation rates of the hypoxanthine-guanine phosphoribosyltransferase (HGPRT or HPRT) gene using a 6-thioguanine (6-TG) assay under various concentrations of MTX selection in CHO cells.	Thioguanine	204-208	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	113-159
20506532-4	2010	Since MTX is often used to generate high producing cell lines, we investigated the genomic mutation rates of the hypoxanthine-guanine phosphoribosyltransferase (HGPRT or HPRT) gene using a 6-thioguanine (6-TG) assay under various concentrations of MTX selection in CHO cells.	Thioguanine	204-208	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	161-166
20222875-6	2010	On the other hand, Lys109Arg and Ser343Ser polymorphism in LEPR gene, but not Gln223Arg or Pro1019Pro, had significant relationships with serum lipid profile; lower total and low-density lipoprotein cholesterol levels in Arg109Arg homozygotes, and lower TG levels in Ser343Ser(C/C) homozygotes.	Thioguanine	254-256	leptin receptor	Homo sapiens	59-63
20811140-3	2010	These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in hypoxanthine phosphoribosyl transferase (Hprt, E.C.2.4.2.8) activity at the frequency of approximately 6.2 x 10(-5).	Thioguanine	82-95	thioredoxin reductase 3	Mus musculus	108-111
20811140-3	2010	These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in hypoxanthine phosphoribosyl transferase (Hprt, E.C.2.4.2.8) activity at the frequency of approximately 6.2 x 10(-5).	Thioguanine	82-95	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	144-183
20811140-3	2010	These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in hypoxanthine phosphoribosyl transferase (Hprt, E.C.2.4.2.8) activity at the frequency of approximately 6.2 x 10(-5).	Thioguanine	82-95	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	185-189
20631063-0	2010	6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.	Thioguanine	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	69-73
20631063-3	2010	In a screen for novel drugs that selectively kill BRCA2-defective cells, we identified 6-thioguanine (6TG), which induces DNA double-strand breaks (DSB) that are repaired by HR.	Thioguanine	87-100	BRCA2 DNA repair associated	Homo sapiens	50-55
20631063-3	2010	In a screen for novel drugs that selectively kill BRCA2-defective cells, we identified 6-thioguanine (6TG), which induces DNA double-strand breaks (DSB) that are repaired by HR.	Thioguanine	102-105	BRCA2 DNA repair associated	Homo sapiens	50-55
20631063-7	2010	We also show that 6TG could kill cells and tumors that have gained resistance to PARP inhibitors or cisplatin through genetic reversion of the BRCA2 gene.	Thioguanine	18-21	poly(ADP-ribose) polymerase 1	Homo sapiens	81-85
20631063-7	2010	We also show that 6TG could kill cells and tumors that have gained resistance to PARP inhibitors or cisplatin through genetic reversion of the BRCA2 gene.	Thioguanine	18-21	BRCA2 DNA repair associated	Homo sapiens	143-148
20177736-6	2010	Highly significant increase in total cholesterol, TG, LDL and significant decrease in HDL level were observed in Ang II treated animals.	Thioguanine	50-52	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	113-116
20019684-2	2010	Triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL) &gt;or=3.0 (in mg/dl) is a marker of insulin resistance in overweight persons.	Thioguanine	60-62	insulin	Homo sapiens	105-112
20615262-1	2010	BACKGROUND: To evaluate the relationship between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and HDL subclass distribution and to further examine and discuss the potential impact of LDL-C and HDL-C together with TG on HDL subclass metabolism.	Thioguanine	267-269	component of oligomeric golgi complex 2	Homo sapiens	90-95
19875996-10	2010	We conclude that lower FFM and greater plasma insulin are associated with greater VLDL-TG deposition in abdominal subcutaneous and femoral fat.	Thioguanine	87-89	insulin	Homo sapiens	46-53
20206139-7	2010	In vivo studies in wild-type and CYP2D6-humanized (Tg-CYP2D6) mouse models showed that Tg-CYP2D6 mice receiving the same dose of 5-MeO-DMT (20mg/kg, i.p.)	Thioguanine	51-53	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	33-39
20206139-7	2010	In vivo studies in wild-type and CYP2D6-humanized (Tg-CYP2D6) mouse models showed that Tg-CYP2D6 mice receiving the same dose of 5-MeO-DMT (20mg/kg, i.p.)	Thioguanine	51-53	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60
20206139-7	2010	In vivo studies in wild-type and CYP2D6-humanized (Tg-CYP2D6) mouse models showed that Tg-CYP2D6 mice receiving the same dose of 5-MeO-DMT (20mg/kg, i.p.)	Thioguanine	51-53	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60
20206139-7	2010	In vivo studies in wild-type and CYP2D6-humanized (Tg-CYP2D6) mouse models showed that Tg-CYP2D6 mice receiving the same dose of 5-MeO-DMT (20mg/kg, i.p.)	Thioguanine	87-89	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	33-39
20206139-7	2010	In vivo studies in wild-type and CYP2D6-humanized (Tg-CYP2D6) mouse models showed that Tg-CYP2D6 mice receiving the same dose of 5-MeO-DMT (20mg/kg, i.p.)	Thioguanine	87-89	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60
20206139-7	2010	In vivo studies in wild-type and CYP2D6-humanized (Tg-CYP2D6) mouse models showed that Tg-CYP2D6 mice receiving the same dose of 5-MeO-DMT (20mg/kg, i.p.)	Thioguanine	87-89	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	54-60
20206139-11	2010	), and 9.9- and 6.1-fold higher systemic exposure to bufotenine in Tg-CYP2D6 and wild-type mice, respectively.	Thioguanine	67-69	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	70-76
21189955-0	2010	A case of Pfeiffer syndrome with c833_834GC&gt;TG (Cys278Leu) mutation in the FGFR2 gene.	Thioguanine	47-49	fibroblast growth factor receptor 2	Homo sapiens	78-83
20580687-1	2010	Paraoxonase-1 (PON1, EC 3.1.8.1) is a high-density lipoprotein (HDL)-associated antioxidant enzyme, and its activity correlates negatively with the level of plasma low-density lipoprotein cholesterol (LDL-C) and triglyceridemia (TG).	Thioguanine	229-231	paraoxonase 1	Rattus norvegicus	0-13
20580687-1	2010	Paraoxonase-1 (PON1, EC 3.1.8.1) is a high-density lipoprotein (HDL)-associated antioxidant enzyme, and its activity correlates negatively with the level of plasma low-density lipoprotein cholesterol (LDL-C) and triglyceridemia (TG).	Thioguanine	229-231	paraoxonase 1	Rattus norvegicus	15-19
20580687-5	2010	The mechanisms of pcDNA/PON1 in treating hyperlipidemia were associated with increases of serum antioxidant PON1 and SOD activities, and with reduction of the levels of total cholesterol (TC), LDL-C and TG.	Thioguanine	203-205	paraoxonase 1	Rattus norvegicus	24-28
20368736-5	2010	Subsequent small-interfering RNA (siRNA)-mediated BNIP3 knockdown abrogates 6-TG-induced autophagy.	Thioguanine	76-80	BCL2 interacting protein 3	Homo sapiens	50-55
20172523-6	2010	On the other hand, nonsmokers carriers of the minor alleles at ABCG5 (i18429C&gt;T and Gln604GluC&gt;G) SNPs had significantly lower TG concentrations (P=0.012 and P=0.035) compared with homozygous for the major allele.	Thioguanine	133-135	ATP binding cassette subfamily G member 5	Homo sapiens	63-68
20368736-0	2010	BNIP3 is essential for mediating 6-thioguanine- and 5-fluorouracil-induced autophagy following DNA mismatch repair processing.	Thioguanine	33-46	BCL2 interacting protein 3	Homo sapiens	0-5
20368736-6	2010	We also found that p53 knockdown or inhibition of mTOR activity by rapamycin cotreatment impairs 6-TG- and 5-FU-induced upregulation of BNIP3 protein levels and autophagy.	Thioguanine	97-101	tumor protein p53	Homo sapiens	19-22
20368736-4	2010	We found that BNIP3 protein levels are upregulated in a MLH1 (MMR(+))-dependent manner following 6-TG and 5-FU treatment.	Thioguanine	97-101	BCL2 interacting protein 3	Homo sapiens	14-19
20368736-4	2010	We found that BNIP3 protein levels are upregulated in a MLH1 (MMR(+))-dependent manner following 6-TG and 5-FU treatment.	Thioguanine	97-101	mutL homolog 1	Homo sapiens	56-60
20368736-6	2010	We also found that p53 knockdown or inhibition of mTOR activity by rapamycin cotreatment impairs 6-TG- and 5-FU-induced upregulation of BNIP3 protein levels and autophagy.	Thioguanine	97-101	mechanistic target of rapamycin kinase	Homo sapiens	50-54
20368736-6	2010	We also found that p53 knockdown or inhibition of mTOR activity by rapamycin cotreatment impairs 6-TG- and 5-FU-induced upregulation of BNIP3 protein levels and autophagy.	Thioguanine	97-101	BCL2 interacting protein 3	Homo sapiens	136-141
20368736-7	2010	Furthermore, suppression of Checkpoint kinase 1 (Chk1) expression with a subsequent reduction in 6-TG-induced G2/M cell cycle arrest by Chk1 siRNA promotes the extent of 6-TG-induced autophagy.	Thioguanine	97-101	checkpoint kinase 1	Homo sapiens	28-47
20368736-7	2010	Furthermore, suppression of Checkpoint kinase 1 (Chk1) expression with a subsequent reduction in 6-TG-induced G2/M cell cycle arrest by Chk1 siRNA promotes the extent of 6-TG-induced autophagy.	Thioguanine	97-101	checkpoint kinase 1	Homo sapiens	49-53
20368736-7	2010	Furthermore, suppression of Checkpoint kinase 1 (Chk1) expression with a subsequent reduction in 6-TG-induced G2/M cell cycle arrest by Chk1 siRNA promotes the extent of 6-TG-induced autophagy.	Thioguanine	97-101	checkpoint kinase 1	Homo sapiens	136-140
20368736-7	2010	Furthermore, suppression of Checkpoint kinase 1 (Chk1) expression with a subsequent reduction in 6-TG-induced G2/M cell cycle arrest by Chk1 siRNA promotes the extent of 6-TG-induced autophagy.	Thioguanine	170-174	checkpoint kinase 1	Homo sapiens	28-47
20368736-7	2010	Furthermore, suppression of Checkpoint kinase 1 (Chk1) expression with a subsequent reduction in 6-TG-induced G2/M cell cycle arrest by Chk1 siRNA promotes the extent of 6-TG-induced autophagy.	Thioguanine	170-174	checkpoint kinase 1	Homo sapiens	49-53
20368736-7	2010	Furthermore, suppression of Checkpoint kinase 1 (Chk1) expression with a subsequent reduction in 6-TG-induced G2/M cell cycle arrest by Chk1 siRNA promotes the extent of 6-TG-induced autophagy.	Thioguanine	170-174	checkpoint kinase 1	Homo sapiens	136-140
20368736-8	2010	These findings suggest that BNIP3 mediates 6-TG- and 5-FU-induced autophagy in a p53- and mTOR-dependent manner.	Thioguanine	43-47	BCL2 interacting protein 3	Homo sapiens	28-33
20368736-8	2010	These findings suggest that BNIP3 mediates 6-TG- and 5-FU-induced autophagy in a p53- and mTOR-dependent manner.	Thioguanine	43-47	tumor protein p53	Homo sapiens	81-84
20368736-8	2010	These findings suggest that BNIP3 mediates 6-TG- and 5-FU-induced autophagy in a p53- and mTOR-dependent manner.	Thioguanine	43-47	mechanistic target of rapamycin kinase	Homo sapiens	90-94
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interleukin 1 beta	Homo sapiens	178-195
20544508-2	2010	The aim of our study was to evaluate the intrapatient variability in the 6-TG metabolizing enzymes: hypoxanthine-guanine phosphoribosyl transferase (HGPRT), thiopurine S-methyl transferase and xanthine oxidase.	Thioguanine	73-77	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-147
20544508-2	2010	The aim of our study was to evaluate the intrapatient variability in the 6-TG metabolizing enzymes: hypoxanthine-guanine phosphoribosyl transferase (HGPRT), thiopurine S-methyl transferase and xanthine oxidase.	Thioguanine	73-77	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	149-154
20544508-2	2010	The aim of our study was to evaluate the intrapatient variability in the 6-TG metabolizing enzymes: hypoxanthine-guanine phosphoribosyl transferase (HGPRT), thiopurine S-methyl transferase and xanthine oxidase.	Thioguanine	73-77	thiopurine S-methyltransferase	Homo sapiens	157-188
20544508-5	2010	From the results we conclude that HGPRT activity in erythrocytes decreases following the initiation of 6-TG therapy, which may imply that HGPRT is a rate limiting enzyme in 6-TG metabolism.	Thioguanine	103-107	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	34-39
20544508-5	2010	From the results we conclude that HGPRT activity in erythrocytes decreases following the initiation of 6-TG therapy, which may imply that HGPRT is a rate limiting enzyme in 6-TG metabolism.	Thioguanine	103-107	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	138-143
20544508-5	2010	From the results we conclude that HGPRT activity in erythrocytes decreases following the initiation of 6-TG therapy, which may imply that HGPRT is a rate limiting enzyme in 6-TG metabolism.	Thioguanine	173-177	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	34-39
20544508-5	2010	From the results we conclude that HGPRT activity in erythrocytes decreases following the initiation of 6-TG therapy, which may imply that HGPRT is a rate limiting enzyme in 6-TG metabolism.	Thioguanine	173-177	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	138-143
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interleukin 2	Homo sapiens	223-227
20124557-11	2010	ApoD was shown to promote LPL-mediated hydrolysis of VLDL in vitro, correlating with its TG-lowering action in vivo.	Thioguanine	89-91	apolipoprotein D	Mus musculus	0-4
20124557-11	2010	ApoD was shown to promote LPL-mediated hydrolysis of VLDL in vitro, correlating with its TG-lowering action in vivo.	Thioguanine	89-91	lipoprotein lipase	Mus musculus	26-29
20124557-11	2010	ApoD was shown to promote LPL-mediated hydrolysis of VLDL in vitro, correlating with its TG-lowering action in vivo.	Thioguanine	89-91	CD320 antigen	Mus musculus	53-57
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	tumor necrosis factor	Homo sapiens	230-257
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	tumor necrosis factor	Homo sapiens	259-268
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interferon gamma	Homo sapiens	274-290
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interleukin 1 beta	Homo sapiens	197-205
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interferon gamma	Homo sapiens	292-301
20815274-1	2010	OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Thioguanine	87-89	interleukin 2	Homo sapiens	208-221
27392985-1	2010	6-mercaptopurine, a key drug for the treatment of acute lymphoblastic leukaemia in children, is a prodrug metabolized into 6-thioguanine (6-TGN) which are the active compounds and into methylated metabolites, primary by thiopurine S-methyltransferase enzyme (TPMT).	Thioguanine	123-136	thiopurine S-methyltransferase	Homo sapiens	220-257
20124398-3	2010	The well characterized substrate for UGT1A1, 7-ethyl-10-hydroxy-camptothecin (SN-38), showed the greatest difference in parent drug exposure ( approximately 3-fold increase) and clearance ( approximately 3-fold decrease) in Tg(UGT1(A1*28)) Ugt1(-/-) mice after intravenous administration compared with wild-type and phenobarbital-treated animals.	Thioguanine	224-226	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	37-43
20124398-3	2010	The well characterized substrate for UGT1A1, 7-ethyl-10-hydroxy-camptothecin (SN-38), showed the greatest difference in parent drug exposure ( approximately 3-fold increase) and clearance ( approximately 3-fold decrease) in Tg(UGT1(A1*28)) Ugt1(-/-) mice after intravenous administration compared with wild-type and phenobarbital-treated animals.	Thioguanine	224-226	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	37-41
20124398-3	2010	The well characterized substrate for UGT1A1, 7-ethyl-10-hydroxy-camptothecin (SN-38), showed the greatest difference in parent drug exposure ( approximately 3-fold increase) and clearance ( approximately 3-fold decrease) in Tg(UGT1(A1*28)) Ugt1(-/-) mice after intravenous administration compared with wild-type and phenobarbital-treated animals.	Thioguanine	224-226	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	240-244
20699069-1	2010	6-mercaptopurine, a key drug for the treatment of acute lymphoblastic leukaemia in children, is a prodrug metabolized into 6-thioguanine (6-TGN) which are the active compounds and into methylated metabolites, primary by thiopurine S-methyltransferase enzyme (TPMT).	Thioguanine	123-136	thiopurine S-methyltransferase	Homo sapiens	220-257
20699069-1	2010	6-mercaptopurine, a key drug for the treatment of acute lymphoblastic leukaemia in children, is a prodrug metabolized into 6-thioguanine (6-TGN) which are the active compounds and into methylated metabolites, primary by thiopurine S-methyltransferase enzyme (TPMT).	Thioguanine	123-136	thiopurine S-methyltransferase	Homo sapiens	259-263
20124398-7	2010	For SN-38 glucuronidation, V(max) decreased 5-fold in Tg(UGT1(A1*28)) Ugt1(-/-) mouse liver microsomes compared with microsomes prepared from wild-type mice, and decreased 10-fold compared with phenobarbital-treated Tg(UGT1(A1*28)) Ugt1(-/-) mice.	Thioguanine	54-56	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	57-61
20124398-7	2010	For SN-38 glucuronidation, V(max) decreased 5-fold in Tg(UGT1(A1*28)) Ugt1(-/-) mouse liver microsomes compared with microsomes prepared from wild-type mice, and decreased 10-fold compared with phenobarbital-treated Tg(UGT1(A1*28)) Ugt1(-/-) mice.	Thioguanine	54-56	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	70-74
27392985-1	2010	6-mercaptopurine, a key drug for the treatment of acute lymphoblastic leukaemia in children, is a prodrug metabolized into 6-thioguanine (6-TGN) which are the active compounds and into methylated metabolites, primary by thiopurine S-methyltransferase enzyme (TPMT).	Thioguanine	123-136	thiopurine S-methyltransferase	Homo sapiens	259-263
20185797-11	2010	Cysteine residues in mitochondrial proteins, including aconitase and NADH dehydrogenases, were oxidized and their activities decreased in Tg-Nox4.	Thioguanine	138-140	NADPH oxidase 4	Mus musculus	141-145
20005292-5	2010	Cardiac expression of ANP and BNP were approximately 2- and approximately 5-fold higher, respectively, in TG(T400N) relative to wildtype (WT) mice at age 2 weeks.	Thioguanine	106-108	natriuretic peptide type B	Mus musculus	30-33
20212262-6	2010	DOCA-TG rats presented a reduction in plasma Ang-(1-7) levels; however, there was a great increase in Ang-(1-7) ( approximately 3-fold) accompanied by a decrease in mRNA expression of both angiotensin-converting enzyme and angiotensin-converting enzyme 2 in the LV.	Thioguanine	5-7	angiogenin	Rattus norvegicus	45-53
20212262-6	2010	DOCA-TG rats presented a reduction in plasma Ang-(1-7) levels; however, there was a great increase in Ang-(1-7) ( approximately 3-fold) accompanied by a decrease in mRNA expression of both angiotensin-converting enzyme and angiotensin-converting enzyme 2 in the LV.	Thioguanine	5-7	angiotensin I converting enzyme	Rattus norvegicus	189-218
20212262-6	2010	DOCA-TG rats presented a reduction in plasma Ang-(1-7) levels; however, there was a great increase in Ang-(1-7) ( approximately 3-fold) accompanied by a decrease in mRNA expression of both angiotensin-converting enzyme and angiotensin-converting enzyme 2 in the LV.	Thioguanine	5-7	angiotensin I converting enzyme 2	Rattus norvegicus	223-254
20087314-4	2010	The 6-thioguanine (6TG) was effective for inducing skipping of both human dystrophin exon 50 (hDysE50) and mouse dystrophin exon 23 (mDysE23) in the cell culture systems and increased exon skipping efficiency (more than threefolds) when used in combination with phosphorodiamidate morpholino oligomers (PMO) in both myoblasts and myotubes.	Thioguanine	4-17	dystrophin	Homo sapiens	74-84
20087314-4	2010	The 6-thioguanine (6TG) was effective for inducing skipping of both human dystrophin exon 50 (hDysE50) and mouse dystrophin exon 23 (mDysE23) in the cell culture systems and increased exon skipping efficiency (more than threefolds) when used in combination with phosphorodiamidate morpholino oligomers (PMO) in both myoblasts and myotubes.	Thioguanine	4-17	dystrophin, muscular dystrophy	Mus musculus	113-123
20087314-4	2010	The 6-thioguanine (6TG) was effective for inducing skipping of both human dystrophin exon 50 (hDysE50) and mouse dystrophin exon 23 (mDysE23) in the cell culture systems and increased exon skipping efficiency (more than threefolds) when used in combination with phosphorodiamidate morpholino oligomers (PMO) in both myoblasts and myotubes.	Thioguanine	19-22	dystrophin	Homo sapiens	74-84
20087314-4	2010	The 6-thioguanine (6TG) was effective for inducing skipping of both human dystrophin exon 50 (hDysE50) and mouse dystrophin exon 23 (mDysE23) in the cell culture systems and increased exon skipping efficiency (more than threefolds) when used in combination with phosphorodiamidate morpholino oligomers (PMO) in both myoblasts and myotubes.	Thioguanine	19-22	dystrophin, muscular dystrophy	Mus musculus	113-123
20138650-3	2010	MeHg, MeHg:THg and TOC decreased with sediment depth within the core for all lakes, whereas THg only showed a decrease in Harp Lake.	Thioguanine	92-95	ankyrin repeat and sterile alpha motif domain containing 4B	Homo sapiens	122-126
20037162-11	2010	In concert with the increase in TG synthesis, the increased PLTP permits triglyceride incorporation into abnormally large VLDL, which are removed from plasma by LDL receptors.	Thioguanine	32-34	phospholipid transfer protein	Mus musculus	60-64
20037162-11	2010	In concert with the increase in TG synthesis, the increased PLTP permits triglyceride incorporation into abnormally large VLDL, which are removed from plasma by LDL receptors.	Thioguanine	32-34	CD320 antigen	Mus musculus	122-126
19959778-2	2010	We hypothesized that phospholamban (PLN) ablation would restore SR Ca(2+) load and prevent the decreased ventricular contractility, dilation and mortality seen in CaMKII-TG.	Thioguanine	170-172	phospholamban	Mus musculus	36-39
20005292-6	2010	NF-kappaB activity and nuclear translocation of the p50 subunit were increased approximately 2- to 3-fold in TG(T400N) hearts relative to WT during the hypertrophic phase.	Thioguanine	109-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
20005292-6	2010	NF-kappaB activity and nuclear translocation of the p50 subunit were increased approximately 2- to 3-fold in TG(T400N) hearts relative to WT during the hypertrophic phase.	Thioguanine	109-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-55
19997406-1	2009	We investigate the influence of THG-cut KDP crystal orientation on laser damage at 1064 nm under nanosecond pulses.	Thioguanine	32-35	WNK lysine deficient protein kinase 1	Homo sapiens	40-43
20165914-6	2010	In fact, TG and dextrin exhibited a flatlined serum glucose pattern, while reducing mean post-prandial serum insulin and glucose concentration as compared to control diet alone.	Thioguanine	9-11	insulin	Canis lupus familiaris	109-116
19946217-0	2010	Acquired resistance to 6-thioguanine in melanoma cells involves the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).	Thioguanine	23-36	O-6-methylguanine-DNA methyltransferase	Homo sapiens	82-120
19946217-0	2010	Acquired resistance to 6-thioguanine in melanoma cells involves the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).	Thioguanine	23-36	O-6-methylguanine-DNA methyltransferase	Homo sapiens	122-126
19946217-6	2010	Treatment with 6-TG diminishes significantly MGMT amounts in both cell lines.	Thioguanine	15-19	O-6-methylguanine-DNA methyltransferase	Homo sapiens	45-49
19946217-8	2010	Pretreatment of cells with the MGMT inhibitor O6 benzyl guanine, resulted in sensitization of GA-6-TG cells to 6-TG.	Thioguanine	97-101	O-6-methylguanine-DNA methyltransferase	Homo sapiens	31-35
19946217-10	2010	In analogy to patients treated with alkylating agents, patients with tumors containing increased MGMT amounts, may be more resistant to 6-TG and therefore may benefit from treatment with MGMT inhibitors.	Thioguanine	136-140	O-6-methylguanine-DNA methyltransferase	Homo sapiens	97-101
19946217-10	2010	In analogy to patients treated with alkylating agents, patients with tumors containing increased MGMT amounts, may be more resistant to 6-TG and therefore may benefit from treatment with MGMT inhibitors.	Thioguanine	136-140	O-6-methylguanine-DNA methyltransferase	Homo sapiens	187-191
24345629-4	2010	Both ALT and GGT but not fasting glucose levels had significant positive associations with total cholesterol, LDL, TG, and UA.	Thioguanine	115-117	gamma-glutamyltransferase light chain family member 3	Homo sapiens	13-16
24345629-5	2010	After adjusting for ALT, GGT remained a significant predictor of total cholesterol, LDL, TG, and UA, but ALT did not remain a significant predictor of these variables after adjusting for GGT.	Thioguanine	89-91	gamma-glutamyltransferase light chain family member 3	Homo sapiens	25-28
19778293-6	2009	MEFs (mouse embryonic fibroblasts) from Trx2-overexpressing transgenic (Trx2 Tg) mice produced less intracellular ROS compared with WT (wild-type) MEFs at the more oxidizing extracellular conditions.	Thioguanine	77-79	thioredoxin 2	Mus musculus	40-44
19778293-6	2009	MEFs (mouse embryonic fibroblasts) from Trx2-overexpressing transgenic (Trx2 Tg) mice produced less intracellular ROS compared with WT (wild-type) MEFs at the more oxidizing extracellular conditions.	Thioguanine	77-79	thioredoxin 2	Mus musculus	72-76
19995332-2	2009	After the analyses by liquid chromatography coupled with tandem mass spectrometry, DMI biotransformations were compared in Tg-CYP2D6 and wild-type mouse liver microsomes (MLM), and in human CYP2D6 extensive and poor metabolizer liver microsomes.	Thioguanine	123-125	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	126-132
19995332-3	2009	Furthermore, urinary DMI metabolic profiles in Tg-CYP2D6 and wild-type mice were evaluated.	Thioguanine	47-49	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	50-56
19772888-7	2009	RESULTS: Injection with jak2a(V581F) mRNA significantly increased erythropoiesis, as enumerated by flow cytometry based on gfp(+) population in dissociated Tg(gata1:gfp) embryos.	Thioguanine	156-158	Janus kinase 2a	Danio rerio	24-29
20025921-2	2010	To examine the potential interactions between mismatch repair and base excision repair (BER) we have examined the effect of MSH2 knockdown on 6-thioguanine (6-TG), temozolomide (TMZ) and methylmethane sulphonate (MMS) induced toxicity in BER proficient and deficient cell lines.	Thioguanine	142-155	mutS homolog 2	Homo sapiens	124-128
20025921-2	2010	To examine the potential interactions between mismatch repair and base excision repair (BER) we have examined the effect of MSH2 knockdown on 6-thioguanine (6-TG), temozolomide (TMZ) and methylmethane sulphonate (MMS) induced toxicity in BER proficient and deficient cell lines.	Thioguanine	157-161	mutS homolog 2	Homo sapiens	124-128
20025921-7	2010	Msh2 knockdown resulted in increased resistance to 6-TG in BER (MPG and NTH1) proficient and deficient cell lines with similar levels of knockdown (84+/-4%) but increased resistance to TMZ only in Mpg+/+ and Nth1(-/-) cell lines and not Mpg(-/-) or Nth1+/+ cells as assessed by an MTT assay.	Thioguanine	51-55	mutS homolog 2	Homo sapiens	0-4
20205861-8	2010	In addition, we observed a positive correlation between PAI-1 and total cholesterol (r = 0.78; p &lt; 0.0009), PAI-1 and LDL-c (r = 0.69; p &lt; 0.006) and PAI-1 and TG levels (r = 0.56; p &lt; 0.03).	Thioguanine	166-168	serpin family E member 1	Homo sapiens	56-61
20205861-8	2010	In addition, we observed a positive correlation between PAI-1 and total cholesterol (r = 0.78; p &lt; 0.0009), PAI-1 and LDL-c (r = 0.69; p &lt; 0.006) and PAI-1 and TG levels (r = 0.56; p &lt; 0.03).	Thioguanine	166-168	component of oligomeric golgi complex 2	Homo sapiens	121-126
23136604-1	2010	Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds including thiopurine drugs such as 6-mercaptopurine, 6-thioguanine and azathioprine.	Thioguanine	169-182	thiopurine S-methyltransferase	Homo sapiens	0-30
23136604-1	2010	Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds including thiopurine drugs such as 6-mercaptopurine, 6-thioguanine and azathioprine.	Thioguanine	169-182	thiopurine S-methyltransferase	Homo sapiens	32-36
20424363-9	2010	By univariate linear regression analysis, fasting serum adiponectin values were positively correlated with age (r=0.242; p=0.017) and high density lipoprotein-cholesterol concentration (HDL-cholesterol; r=0.267; p=0.008) but were negatively correlated with triglyceride concentration (TG; r=-0.251; p=0.013).	Thioguanine	285-287	adiponectin, C1Q and collagen domain containing	Homo sapiens	56-67
19875331-0	2009	Influences of urea and guanidine hydrochloride on the interaction of 6-thioguanine with bovine serum albumin.	Thioguanine	69-82	albumin	Homo sapiens	95-108
19875331-1	2009	The interaction of 6-thioguanine (6-TG) and bovine serum albumin (BSA) in the absence and presence of denaturant (urea and Guanidine hydrochloride) was investigated by fluorescence spectroscopic techniques.	Thioguanine	19-32	albumin	Homo sapiens	51-64
19679826-5	2009	Treatment of macrophages with VLDL and triacsin C resulted in reduced TG accumulation but increased intracellular FFA levels, which induced lipotoxicity characterized by apoptosis.	Thioguanine	70-72	CD320 antigen	Mus musculus	30-34
19851169-6	2009	CONCLUSIONS: Our results indicate that F-18 FDG-PET/CT is a useful diagnostic tool in patients with differentiated thyroid carcinoma and with negative I-131 total body scans and high Tg levels.	Thioguanine	183-185	mastermind like domain containing 1	Homo sapiens	39-43
19858416-8	2009	These changes were exacerbated in Tg-S466L Cbs(-/-) mice with aging.	Thioguanine	34-36	cystathionine beta-synthase	Mus musculus	43-46
19820968-4	2009	HCN4 was present in 9% of TG neurons and 4.7% of DRG neurons, it was distributed in a discrete population of small-diameter neurons in the TG but was located in cells of all sizes in the DRG.	Thioguanine	26-28	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	Rattus norvegicus	0-4
19851169-7	2009	The levothyroxine therapy regimen does not influence F-18 FDG-PET/CT results and the rate of F-18 FDG-PET/CT positive results appears to correlate with the Tg levels.	Thioguanine	156-158	mastermind like domain containing 1	Homo sapiens	93-97
19851169-1	2009	PURPOSE: The aim was to evaluate the incremental diagnostic rate of F-18 fluoro-fluorodeoxygulose positron emission tomography/computed tomography (F-18 FDG-PET/CT) in patients with negative I-131 whole body scans and high Tg levels.	Thioguanine	223-225	mastermind like domain containing 1	Homo sapiens	68-72
19609565-0	2009	Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation.	Thioguanine	83-85	neurogenic differentiation 1	Mus musculus	40-47
19851169-1	2009	PURPOSE: The aim was to evaluate the incremental diagnostic rate of F-18 fluoro-fluorodeoxygulose positron emission tomography/computed tomography (F-18 FDG-PET/CT) in patients with negative I-131 whole body scans and high Tg levels.	Thioguanine	223-225	mastermind like domain containing 1	Homo sapiens	148-152
19851169-4	2009	RESULTS: We noted a statistically significant positive correlation between F-18 FDG-PET/CT positive results and Tg levels, irrespective of levothyroxine therapy regimen.	Thioguanine	112-114	mastermind like domain containing 1	Homo sapiens	75-79
19657147-5	2009	A specific site-directed inhibitor of TG abolished the NF-kappaB and TGFbeta1 activation and the subsequent elevation in the synthesis and deposition of extracellular matrix proteins, confirming that this process depends on the induction of transglutaminase activity.	Thioguanine	38-40	transforming growth factor beta 1	Homo sapiens	69-77
19526250-5	2009	Our data indicate that the rs1260326 T allele of GCKR is associated with both higher fasting levels of TG as well as the postprandial TG response, which may result in higher atherogenic risk.	Thioguanine	103-105	glucokinase regulator	Homo sapiens	49-53
19526250-5	2009	Our data indicate that the rs1260326 T allele of GCKR is associated with both higher fasting levels of TG as well as the postprandial TG response, which may result in higher atherogenic risk.	Thioguanine	134-136	glucokinase regulator	Homo sapiens	49-53
20030174-5	2009	Serum apoB-48 concentration was measured by chemiluminescence enzyme immunoassay (CLEIA) and it correlated with thyroid stimulating hormone (TSH), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglycerides(TG), but negatively correlated with free thyroxine (FT4) and free triiodothyronine (FT3).	Thioguanine	233-235	apolipoprotein B	Homo sapiens	6-13
19609565-0	2009	Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation.	Thioguanine	83-85	atonal bHLH transcription factor 1	Mus musculus	86-91
19307976-10	2009	Serine phosphorylation of glycogen synthase kinase 3alpha was decreased in Tg mice and liver glycogen content was decreased correspondingly.	Thioguanine	75-77	glycogen synthase kinase 3 alpha	Mus musculus	26-57
19716472-2	2009	This ribozyme, called pR1, when derivatized with ribose 5-phosphate (PR) at its 3" terminus and incubated with 6-thioguanine, produces two interconverting thiol-containing products corresponding to a Schiff base and its Amadori rearranged product.	Thioguanine	111-124	transmembrane protein 37	Homo sapiens	22-25
19414540-6	2009	hCG pretreatment in TG-induced peritonitis increased the number of peritoneal cells, especially PMN and monocytes, compared with mice injected with TG only.	Thioguanine	20-22	glycoprotein hormones, alpha polypeptide	Homo sapiens	0-3
21291825-6	2009	RESULTS: The SCD indexes C18:1/18:0 and C16:1/C16:0 were significantly (P &lt; .0001) correlated with serum TG with R(2) values of 0.71 and 0.58.	Thioguanine	108-110	stearoyl-CoA desaturase	Homo sapiens	13-16
19535798-1	2009	Thiopurine methyltransferase (TPMT)is involved in the metabolism of thiopurines such as 6-mercaptopurine and 6-thioguanine.	Thioguanine	109-122	thiopurine S-methyltransferase	Homo sapiens	30-34
19506101-6	2009	The angiotensin II-induced hypertension in wild-type mice (145+/-2 mm Hg) was significantly attenuated in Tg(hTrx2) mice (124+/-1 mm Hg; P&lt;0.001).	Thioguanine	106-108	thioredoxin 2	Homo sapiens	109-114
19506101-8	2009	Elevated vascular superoxide and hydrogen peroxide levels, as well as expression of NADPH oxidase subunits in response to angiotensin II infusion, were significantly attenuated in Tg(hTrx2) mice.	Thioguanine	180-182	thioredoxin 2	Homo sapiens	183-188
19414540-6	2009	hCG pretreatment in TG-induced peritonitis increased the number of peritoneal cells, especially PMN and monocytes, compared with mice injected with TG only.	Thioguanine	148-150	glycoprotein hormones, alpha polypeptide	Homo sapiens	0-3
19603033-6	2009	In addition, the presence of wild-type hMLH1 or hMLH1 re-expression significantly increased sensitivity to 6-thioguanine, a MMR-dependent agent.	Thioguanine	107-120	mutL homolog 1	Homo sapiens	39-44
18992051-1	2009	Minimal data exist on the perioperative use of TG for induction in pediatric HTx recipients.	Thioguanine	47-49	Zic family member 3	Homo sapiens	77-80
18992051-2	2009	We report our experience using continuous infusion of TG on (i) perioperative adverse events, (ii) rejection, (iii) CAV, and (iv) PTLD.	Thioguanine	54-56	caveolin 2	Homo sapiens	116-119
19603033-6	2009	In addition, the presence of wild-type hMLH1 or hMLH1 re-expression significantly increased sensitivity to 6-thioguanine, a MMR-dependent agent.	Thioguanine	107-120	mutL homolog 1	Homo sapiens	48-53
19603033-7	2009	Cell-death response to 6-thioguanine and cisplatin was associated with significant proteolysis of MLH1, with XIAP destabilisation and increased caspase-3 activity.	Thioguanine	23-36	mutL homolog 1	Homo sapiens	98-102
19603033-7	2009	Cell-death response to 6-thioguanine and cisplatin was associated with significant proteolysis of MLH1, with XIAP destabilisation and increased caspase-3 activity.	Thioguanine	23-36	X-linked inhibitor of apoptosis	Homo sapiens	109-113
19603033-7	2009	Cell-death response to 6-thioguanine and cisplatin was associated with significant proteolysis of MLH1, with XIAP destabilisation and increased caspase-3 activity.	Thioguanine	23-36	caspase 3	Homo sapiens	144-153
19659999-7	2009	After rosiglitazone treatment for 12 consecutive weeks, we found that A allele carriers of UCP2 in the T2DM patients had smaller attenuated PINS (-3.82 +/- 13.2 vs.-42.1 +/- 30.7 mU l(-1), P &lt; 0.01) (9.45, 51.31 vs. 0.48, 11.88) and greater attenuated HbA(1c) (-1.85 +/- 1.62 vs.-0.61 +/- 0.80, P &lt; 0.05) (0.14, 1.37 vs. 1.10, 2.38) compared with GG genotypes, and ADRB3 Trp64Arg had greater attenuated serum TG (-3.88 +/- 2.77 vs.-0.24 +/- 1.16 mmol l(-1), P &lt; 0.05) (-0.19, 2.74 vs. 1.19, 1.45) and smaller attenuated LDL-cholesterol (1.08 +/- 1.36 vs.-0.36 +/- 0.99, P &lt; 0.01) (-1.26, 0.78 vs.-1.26, 0.79) as well as reduced enhanced adiponectin (1.57 +/- 1.10 vs. 3.15 +/- 2.12 mmol l(-1), P &lt; 0.05) (1.68, 4.08 vs.-9.18, 11.40) compared with ADRB3 Trp64Trp.	Thioguanine	415-417	uncoupling protein 2	Homo sapiens	91-95
19318376-10	2009	Consistently, calpain activity, caspase-3 activity, and TNF-alpha expression were also reduced in CAST-Tg and calpain inhibitor-III compared with wild-type and vehicle-treated hearts, respectively.	Thioguanine	103-105	caspase 3	Mus musculus	32-41
19318376-10	2009	Consistently, calpain activity, caspase-3 activity, and TNF-alpha expression were also reduced in CAST-Tg and calpain inhibitor-III compared with wild-type and vehicle-treated hearts, respectively.	Thioguanine	103-105	tumor necrosis factor	Mus musculus	56-65
19689083-13	2009	CONCLUSION: PC can reduce the levels of TG, TC and PC can reduce the activities of NF-kappaB of thoracic aorta of hyperlipemia rats by preventing the expressions of PPARgamma mRNA downregulating.	Thioguanine	40-42	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	165-174
21172256-4	2009	Our case demonstrates that very low dose 6-TG under close clinical surveillance and frequent therapeutic drug monitoring, may be a rescue drug for IBD-patients with low or without functional TPMT activity.	Thioguanine	41-45	thiopurine S-methyltransferase	Homo sapiens	191-195
19136674-0	2009	Mutations at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine.	Thioguanine	70-83	guanylate kinase 1	Mus musculus	32-48
19957617-10	2009	Even the aRR was much weakened after the baseline SBP, DBP were adjusted with Cox model, the significant relation of hypertension to HDL-C, TC/HDL-C ratio and TG still existed.	Thioguanine	159-161	cytochrome c oxidase subunit 8A	Homo sapiens	78-81
19277603-7	2009	In addition, the circulating CCL2 concentration was associated with increased macrophage accumulation and inflammation as documented by upregulation of Cd68 gene and Tnf-alpha [also known as Tnf] gene in livers from the AZIP-Tg mice.	Thioguanine	225-227	chemokine (C-C motif) ligand 2	Mus musculus	29-33
19675376-1	2009	BACKGROUND &amp; OBJECTIVE: Mercaptopurine, azathioprine, and thioguanine, used as antineoplastic agents and immunosuppressants are catabolized by thiopurine methyltransferase (TPMT) enzyme, which exhibits genetic polymorphism.	Thioguanine	62-73	thiopurine S-methyltransferase	Homo sapiens	147-175
19675376-1	2009	BACKGROUND &amp; OBJECTIVE: Mercaptopurine, azathioprine, and thioguanine, used as antineoplastic agents and immunosuppressants are catabolized by thiopurine methyltransferase (TPMT) enzyme, which exhibits genetic polymorphism.	Thioguanine	62-73	thiopurine S-methyltransferase	Homo sapiens	177-181
19023847-2	2009	The purpose of the study was to investigate the effects of an exercise-training program on hepatic content of MTP and its relation to hepatic VLDL-triglyceride (VLDL-TG) production in response to lipid infusion.	Thioguanine	166-168	microsomal triglyceride transfer protein	Rattus norvegicus	110-113
19478948-12	2009	The combination of MTA with 5-FU or 6-TG, in the treatment of MTAP-negative tumors, may produce a significantly improved therapeutic index.	Thioguanine	36-40	methylthioadenosine phosphorylase	Homo sapiens	62-66
19239905-8	2009	CONCLUSIONS: The Lys166Glu and Ile244Met polymorphisms in apoL-I gene are associated with TG levels in subjects with endogenous hypertriglyceridemia in Chinese.	Thioguanine	90-92	apolipoprotein L1	Homo sapiens	58-64
19136674-2	2009	GMK is also responsible for the activation of 6-thioguanine (6-TG), a drug widely used as chemotherapeutic agent to treat leukemia.	Thioguanine	46-59	guanylate kinase 1	Mus musculus	0-3
19136674-2	2009	GMK is also responsible for the activation of 6-thioguanine (6-TG), a drug widely used as chemotherapeutic agent to treat leukemia.	Thioguanine	61-65	guanylate kinase 1	Mus musculus	0-3
19136674-7	2009	When 6-TG is included in complementation studies, cells expressing wild-type GMK are sensitive whereas all S37 mutants examined are able to effectively discriminate against 6-TG and display a drug resistance phenotype.	Thioguanine	5-9	guanylate kinase 1	Mus musculus	77-80
19135027-7	2009	SERCA inhibitors Tg and tBHQ induced modest inhibition of the ETF.	Thioguanine	17-19	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	0-5
19236003-4	2009	To gain biochemical evidence for this hypothesis, we assessed, by using a restriction enzyme digestion coupled with LC-MS/MS method, the impact of 6-thioguanine on cytosine methylation mediated by two DNA methyltransferases, human DNMT1 and bacterial HpaII.	Thioguanine	147-160	DNA methyltransferase 1	Homo sapiens	231-236
19236003-6	2009	The presence of 6-thioguanine at the methylated CpG site enhanced the DNMT1-mediated methylation of the opposing cytosine in the complementary strand, whereas the presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5" adjacent cytosine by both DNMT1 and HpaII.	Thioguanine	16-29	DNA methyltransferase 1	Homo sapiens	70-75
19236003-6	2009	The presence of 6-thioguanine at the methylated CpG site enhanced the DNMT1-mediated methylation of the opposing cytosine in the complementary strand, whereas the presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5" adjacent cytosine by both DNMT1 and HpaII.	Thioguanine	16-29	DNA methyltransferase 1	Homo sapiens	298-303
19135027-7	2009	SERCA inhibitors Tg and tBHQ induced modest inhibition of the ETF.	Thioguanine	17-19	TEA domain transcription factor 2	Homo sapiens	62-65
19224055-5	2009	ASP-stimulated and insulin-stimulated TGS rate at indicated time points (0 d, 3 d, 6 d, 9 d) were assayed by measuring the incorporation of [(3)H]-oleic acid into TG, and the corresponding glucose transport was assayed by [(3)H]-2-DG uptake.	Thioguanine	38-40	insulin	Homo sapiens	19-26
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Thioguanine	52-54	cystathionine beta-synthase	Mus musculus	61-64
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Thioguanine	52-54	cystathionine beta-synthase	Mus musculus	287-290
18987302-5	2009	Metabolic profiling of serum and liver reveals that Tg-I278T Cbs(-/-) mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs(-/-) mice.	Thioguanine	279-281	cystathionine beta-synthase	Mus musculus	61-64
18987302-6	2009	RNA profiling of livers indicate that Tg-I278T Cbs(-/-) and Tg-hCBS Cbs(-/-) mice have unique gene signatures, with minimal overlap.	Thioguanine	38-40	cystathionine beta-synthase	Mus musculus	47-50
19083071-10	2009	Six months after surgery, we found a significant reduction in C-IMT (p&lt;0.05), which was significantly correlated with TG level and systolic pressure (p&lt;0.05).	Thioguanine	121-123	CIMT	Homo sapiens	62-67
19552838-8	2009	Partial correlation analyses showed that the serum Chemerin was positively correlated with waist circumference, WHR, fasting serum C peptide, HOMA-IR, TG, ALT, gamma-GT, and uric acid (r = 0.460 - 0.182, all P &lt; 0.05) and negatively correlated with high density lipoprotein-cholesterol (r = -0.251, P &lt; 0.01).	Thioguanine	151-153	retinoic acid receptor responder 2	Homo sapiens	51-59
19036079-5	2009	This was more notable in children who received idarubicin, fludarabine, ara-C, and granulocyte colony-stimulating factor (IDA-FLAG; ara-C = 7590 mg/m2) (5-year TRM 24 +/- 21% CC vs. 6 +/- 6% AA, 6 +/- 7% AC, P = 0.07) as consolidation therapy compared to idarubicin, dexamethasone, cytarabine, thioguanine, etoposide and daunomycin (IDA-DCTER; ara-C = 800 mg/m2) (5-year TRM 15 +/- 20% CC vs. 8 +/- 6% AA, 4 +/- 6% AC; P = 0.29).	Thioguanine	294-305	colony stimulating factor 3	Homo sapiens	83-120
18948612-2	2009	This study elucidates how various hypoxic interventions impact endogenous thrombin generation (TG) after treatment with/without lipophilic antioxidant vitamin E.	Thioguanine	95-97	coagulation factor II, thrombin	Homo sapiens	74-82
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	Thioguanine	151-153	8-oxoguanine DNA glycosylase	Homo sapiens	20-48
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	Thioguanine	151-153	8-oxoguanine DNA glycosylase	Homo sapiens	50-55
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	Thioguanine	151-153	8-oxoguanine DNA glycosylase	Homo sapiens	241-246
18948612-7	2009	However, depletion of FVIII by incubation with anti-FVIII antibodies in plasma suppressed enhancement of TG by severe hypoxia.	Thioguanine	105-107	coagulation factor VIII	Homo sapiens	22-27
18948612-7	2009	However, depletion of FVIII by incubation with anti-FVIII antibodies in plasma suppressed enhancement of TG by severe hypoxia.	Thioguanine	105-107	coagulation factor VIII	Homo sapiens	52-57
18948612-10	2009	CONCLUSIONS: We conclude that severe hypoxia promotes FVIII-dependent TG, likely by elevating oxidative stress; this hypoxic effect was ameliorated by pretreatment with vitamin E.	Thioguanine	70-72	coagulation factor VIII	Homo sapiens	54-59
19073277-3	2009	To validate the model, conditions were determined for in vitro selection and expansion of 6-thioguanine-resistant (6-TGr) HPRT mutant and proaerolysin-resistant (ProAERr) PIG-A mutant lymphocytes from peripheral blood obtained by routine venipuncture.	Thioguanine	90-103	hypoxanthine phosphoribosyltransferase 1	Sus scrofa	122-126
19149855-6	2009	In vitro experiments, the 50% of maximum TG peak (TGMP) was achieved using only 5% FVIII:C and the TGMP was obtained with 40% of normal VIII:C. Impaired response compared with normal plasma was found in FVIIIDP using addition of increasing amounts of different commercial FVIII concentrates.	Thioguanine	41-43	coagulation factor VIII	Homo sapiens	83-88
19258676-7	2009	For metabolic syndrome, hypoadiponectinemia showed the OR value of 6.0 (95% CI 2.13 to 16.98); insulin resistance showed the OR value of 5.7 (95% CI 1.3 to 25.02), after adjustment for waist circumference, TG, HLD, blood pressure, fasting blood glucose.	Thioguanine	206-208	insulin	Homo sapiens	95-102
18986321-11	2009	Conversely, overexpression of DGAT2 in glycolytic muscle resulted in accumulation of TG and ceramide and insulin resistance in these tissues.	Thioguanine	85-87	diacylglycerol O-acyltransferase 2	Mus musculus	30-35
19835569-7	2009	Several conditions such as metabolic syndrome, hypertension, insulin resistance, obesity and familial hypercholesterolaemia are characterized by a more pronounced postprandial hypertriglyceridemia and delayed TG clearance than normal states.	Thioguanine	209-211	insulin	Homo sapiens	61-68
19121805-11	2009	Moreover, the degree of extensive interstitial fibrosis in the left atrium was greater in G(alpha)q-TG hearts than that in G(alpha)q/DGKzeta-TG hearts (P &lt;.05).	Thioguanine	100-102	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	90-99
19811436-8	2009	PGA patients with autoimmune thyroid disease and the TNF-alpha; -308 AA genotype showed the highest prevalence of thyroid autoantibodies (TPO, P = 0.04; Tg, P = 0.003).	Thioguanine	153-155	tumor necrosis factor	Homo sapiens	53-62
18956219-6	2009	Multivariate analysis revealed that HDL-2 levels and the HDL-2/HDL-3 ratio significantly and independently correlated with HDL-C (positively) and TG (negatively) levels.	Thioguanine	146-148	junctophilin 3	Homo sapiens	36-41
18791169-11	2009	The mean IOP of ODAG Tg was significantly higher than that of wild-type (WT) littermates.	Thioguanine	21-23	GATA zinc finger domain containing 1	Mus musculus	16-20
18956219-6	2009	Multivariate analysis revealed that HDL-2 levels and the HDL-2/HDL-3 ratio significantly and independently correlated with HDL-C (positively) and TG (negatively) levels.	Thioguanine	146-148	junctophilin 3	Homo sapiens	57-62
18956219-6	2009	Multivariate analysis revealed that HDL-2 levels and the HDL-2/HDL-3 ratio significantly and independently correlated with HDL-C (positively) and TG (negatively) levels.	Thioguanine	146-148	HDL3	Homo sapiens	63-68
18956219-7	2009	HDL-3 concentration significantly and independently positively correlated with HDL-C and TG levels.	Thioguanine	89-91	HDL3	Homo sapiens	0-5
19122448-10	2009	In the thyroid parenchyma of ghrelin-treated rats, an increased number of hypofunctioning follicles was noticed, characterized by flattened, weakly Tg-immunoreactive epithelium and colloid distension.	Thioguanine	148-150	ghrelin and obestatin prepropeptide	Rattus norvegicus	29-36
18644833-8	2008	In unirradiated mice, the dietary supplement significantly reduced constitutive gammaH2AX and 8-OHdG in both Nr and Tg mice (normalizing both gammaH2AX and 8-OHdG in Tg), with little difference in gammaH2AX and 8-OHdG over constitutive levels.	Thioguanine	166-168	H2A.X variant histone	Mus musculus	80-89
18793759-4	2008	Using the hOGG1 comet assay, we herein demonstrate high levels of 8-oxodG and alkali-labile sites (ALS) in cells treated with biologically relevant doses of 6-TG, or Aza, plus UVA.	Thioguanine	157-161	8-oxoguanine DNA glycosylase	Homo sapiens	10-15
18793759-7	2008	We speculate that some activity of hOGG1 towards unirradiated, 6-TG treated cells, implies possible recognition of 6-TG or derivatives thereof.	Thioguanine	63-67	8-oxoguanine DNA glycosylase	Homo sapiens	35-40
18793759-7	2008	We speculate that some activity of hOGG1 towards unirradiated, 6-TG treated cells, implies possible recognition of 6-TG or derivatives thereof.	Thioguanine	115-119	8-oxoguanine DNA glycosylase	Homo sapiens	35-40
18762718-4	2008	The predicted amino acid sequence of porcine CBF-A showed a unique insertion of five TG-repeats in the N-terminal region in comparison with those of other mammals, whereas the other regions appeared to be mostly conserved including two RNA recognition motifs in the middle region.	Thioguanine	85-87	heterogeneous nuclear ribonucleoprotein A/B	Mus musculus	45-50
19046568-5	2008	The actions of glucagon on TG synthesis and FAO were abolished in PPARalpha-/- hepatocytes.	Thioguanine	27-29	peroxisome proliferator activated receptor alpha	Mus musculus	66-75
18688176-4	2008	Statistical analysis revealed that RUNX2-742G &gt; T was associated with serum triglyceride level (TG) in nondiabetic controls, although it was not associated with the risk of T2DM.	Thioguanine	99-101	RUNX family transcription factor 2	Homo sapiens	35-40
18708030-4	2008	Since SAM levels are dependent on de novo purine synthesis (DNPS) and the metabolic products of 6-TG and 6-MP differ in their ability to inhibit DNPS, we postulated that 6-TG compared to 6-MP would have differential effects on changes in SAM and SAH levels and global DNA methylation, depending on TPMT status.	Thioguanine	170-174	thiopurine S-methyltransferase	Homo sapiens	298-302
18708030-7	2008	Inhibition was influenced by TPMT for 6-TG, but not 6-MP.	Thioguanine	38-42	thiopurine S-methyltransferase	Homo sapiens	29-33
18708030-8	2008	The decrease in global methylation and DNMT activity with 6-MP, or with 6-TG when TPMT expression was low, were comparable to 5-aza-2"-deoxycytidine.	Thioguanine	72-76	DNA methyltransferase 1	Homo sapiens	39-43
18708030-8	2008	The decrease in global methylation and DNMT activity with 6-MP, or with 6-TG when TPMT expression was low, were comparable to 5-aza-2"-deoxycytidine.	Thioguanine	72-76	thiopurine S-methyltransferase	Homo sapiens	82-86
18708030-10	2008	The results suggest that a non-TPMT metabolised metabolite of 6-MP and 6-TG and the TPMT-metabolised 6-MP metabolite 6-methylthioguanosine 5"-monophosphate, contribute to a decrease in DNMT levels and global DNA methylation.	Thioguanine	71-75	DNA methyltransferase 1	Homo sapiens	185-189
18631405-4	2008	The aim of this study was to investigate the relationship between preeclampsia and a dinucleotide (threonine-glycine; TG)n repeat polymorphism in the 3" non-coding region of the Flt-1 gene.	Thioguanine	118-120	fms related receptor tyrosine kinase 1	Homo sapiens	178-183
18947406-9	2008	RESULTS: In TNFalpha-Tg rat brain, the aggregate mouse and rat TNFalpha mRNA level was fourfold higher than in non-Tg littermates and the corresponding TNFalpha protein level was increased fivefold (p &lt;or= 0.01).	Thioguanine	21-23	tumor necrosis factor	Rattus norvegicus	12-20
18947406-9	2008	RESULTS: In TNFalpha-Tg rat brain, the aggregate mouse and rat TNFalpha mRNA level was fourfold higher than in non-Tg littermates and the corresponding TNFalpha protein level was increased fivefold (p &lt;or= 0.01).	Thioguanine	21-23	tumor necrosis factor	Rattus norvegicus	63-71
18947406-9	2008	RESULTS: In TNFalpha-Tg rat brain, the aggregate mouse and rat TNFalpha mRNA level was fourfold higher than in non-Tg littermates and the corresponding TNFalpha protein level was increased fivefold (p &lt;or= 0.01).	Thioguanine	21-23	tumor necrosis factor	Rattus norvegicus	63-71
18801202-9	2008	The Sac1 and -75G&gt;A SNPs along with hypertension showed maximized correlations with TC, TG and Apo B by association analysis.	Thioguanine	91-93	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	4-8
18652668-27	2008	Significant differences in CRP levels are reported between each TG compared to the corresponding CG, but not significantly different between each TG and between each CG.	Thioguanine	64-66	C-reactive protein	Homo sapiens	27-30
18635818-7	2008	CONCLUSIONS: The in vitro determined function of these apoAV variants only partly explains the high TG levels seen in carriers.	Thioguanine	100-102	apolipoprotein A5	Homo sapiens	55-60
19009762-4	2008	LDL-C was measured by the homogeneous method, and calculated by the Friedewald formula LDL-C = TC-HDL-(TG/2.2) (LDL1) and alternative formulas LDL-C = 0.41 TC - 0.32 TG + 1.70 apoB - 0.27 (LDL2) and LDL-C = 0.94 TC - 0.94 HDL - 0.435 TG (LDL3).	Thioguanine	103-105	component of oligomeric golgi complex 2	Homo sapiens	0-5
19009762-4	2008	LDL-C was measured by the homogeneous method, and calculated by the Friedewald formula LDL-C = TC-HDL-(TG/2.2) (LDL1) and alternative formulas LDL-C = 0.41 TC - 0.32 TG + 1.70 apoB - 0.27 (LDL2) and LDL-C = 0.94 TC - 0.94 HDL - 0.435 TG (LDL3).	Thioguanine	166-168	component of oligomeric golgi complex 2	Homo sapiens	0-5
19009762-4	2008	LDL-C was measured by the homogeneous method, and calculated by the Friedewald formula LDL-C = TC-HDL-(TG/2.2) (LDL1) and alternative formulas LDL-C = 0.41 TC - 0.32 TG + 1.70 apoB - 0.27 (LDL2) and LDL-C = 0.94 TC - 0.94 HDL - 0.435 TG (LDL3).	Thioguanine	166-168	component of oligomeric golgi complex 2	Homo sapiens	0-5
19009762-9	2008	Linear regression analysis showed correlation of calculated LDL-C values with the direct method in the range of r = 0.82 - 0.90 (p &lt; 0.0001 for all, except of LDL2 in 1.7 &lt; or = TG &lt; 4.5 mmol/l group where p = 0.0011).	Thioguanine	184-186	component of oligomeric golgi complex 2	Homo sapiens	60-65
18753372-4	2008	Increased COMT enzyme activity in Val-tg mice resulted in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity.	Thioguanine	38-40	catechol-O-methyltransferase	Mus musculus	10-14
18581104-3	2008	Furthermore, we successfully demonstrated an enzyme reaction in which the fluorogenic substrate TokyoGreen-beta-galactoside (TG-beta-gal) was hydrolyzed to the fluorescein derivative TokyoGreen (TG) and beta-galactose by the action of beta-galactosidase enzyme as a calalyst in a Y-shaped extended nanospace channel.	Thioguanine	125-127	galactosidase beta 1	Homo sapiens	235-253
18624299-8	2008	The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted.	Thioguanine	65-67	gag protein	Friend murine leukemia virus	61-64
18375436-2	2008	The main aims of this study are to investigate the effects of adiponectin on VLDL triglyceride (VLDL-TG) metabolism and the underlying mechanism.	Thioguanine	101-103	adiponectin, C1Q and collagen domain containing	Mus musculus	62-73
18375436-2	2008	The main aims of this study are to investigate the effects of adiponectin on VLDL triglyceride (VLDL-TG) metabolism and the underlying mechanism.	Thioguanine	101-103	CD320 antigen	Mus musculus	77-81
18375436-12	2008	CONCLUSIONS: These results suggest that adiponectin decreases plasma TG levels by increasing skeletal muscle LPL and VLDLr expression and consequently VLDL-TG catabolism.	Thioguanine	69-71	very low density lipoprotein receptor	Mus musculus	117-122
18375436-12	2008	CONCLUSIONS: These results suggest that adiponectin decreases plasma TG levels by increasing skeletal muscle LPL and VLDLr expression and consequently VLDL-TG catabolism.	Thioguanine	69-71	CD320 antigen	Mus musculus	117-121
18375436-2	2008	The main aims of this study are to investigate the effects of adiponectin on VLDL triglyceride (VLDL-TG) metabolism and the underlying mechanism.	Thioguanine	101-103	CD320 antigen	Mus musculus	96-100
18375436-7	2008	Fasting plasma TG levels were significantly decreased (approximately 40%) in the mice with elevated adiponectin in circulation, as were the plasma levels of large and medium VLDL subclasses.	Thioguanine	15-17	adiponectin, C1Q and collagen domain containing	Mus musculus	100-111
18375436-12	2008	CONCLUSIONS: These results suggest that adiponectin decreases plasma TG levels by increasing skeletal muscle LPL and VLDLr expression and consequently VLDL-TG catabolism.	Thioguanine	69-71	adiponectin, C1Q and collagen domain containing	Mus musculus	40-51
18375436-12	2008	CONCLUSIONS: These results suggest that adiponectin decreases plasma TG levels by increasing skeletal muscle LPL and VLDLr expression and consequently VLDL-TG catabolism.	Thioguanine	69-71	lipoprotein lipase	Mus musculus	109-112
19100082-5	2008	RESULTS: (1) Compared with CAD group, PCAD patients had significantly higher rate of smoking (50.3% vs. 38.0%, P &lt; 0.05), significantly higher positive CAD family history rate (29.7% vs. 19.9%, P &lt; 0.05) and significantly higher TG level [(2.13 +/- 1.89) mmol/L vs. (1.78 +/- 1.14) mmol/L, P &lt; 0.05], while had significantly fewer traditional risk factors (2.50 +/- 1.28 vs. 2.76 +/- 1.43, P &lt; 0.05) and lower hypertension rate (59.3% vs. 73.3%, P &lt; 0.05).	Thioguanine	235-237	cadherin 3	Homo sapiens	38-42
18575520-5	2008	By linking LEQDs with anti-Her2 antibodies, the expression of Her2/neu receptors in live breast cancer cells could also be easily detected through THG.	Thioguanine	147-150	erb-b2 receptor tyrosine kinase 2	Mus musculus	27-31
18575520-5	2008	By linking LEQDs with anti-Her2 antibodies, the expression of Her2/neu receptors in live breast cancer cells could also be easily detected through THG.	Thioguanine	147-150	erb-b2 receptor tyrosine kinase 2	Mus musculus	62-70
18506369-14	2008	An association of the apoAI -75 bp G/A and serum TG, LDL-C and apoA-I levels in Hei Yi Zhuang and serum TG, HDL-C and apoB levels in Han was also observed in this study.	Thioguanine	104-106	apolipoprotein A1	Homo sapiens	63-69
18483248-6	2008	Homology-dependent recombination repair predominated in Fhit-deficient cells, although not error-free repair, as indicated by a higher incidence of 6-thioguanine-resistant colonies.	Thioguanine	148-161	fragile histidine triad gene	Mus musculus	56-60
18453577-4	2008	Using transgenic mice expressing a stabilized beta-catenin (beta-cat(Tg)), we show here that beta-catenin was able to enhance apoptosis of activated T cells by up-regulating Fas.	Thioguanine	69-71	catenin (cadherin associated protein), beta 1	Mus musculus	46-58
18453577-4	2008	Using transgenic mice expressing a stabilized beta-catenin (beta-cat(Tg)), we show here that beta-catenin was able to enhance apoptosis of activated T cells by up-regulating Fas.	Thioguanine	69-71	catenin (cadherin associated protein), beta 1	Mus musculus	93-105
18192500-10	2008	Gene expression (procollagen 3-a-1, procollagen 1-a-1, and IL-6) linked to fibrogenesis was also increased in lung homogenates of asbestos-exposed Tg- mice, but reduced in asbestos-exposed Tg+ mice.	Thioguanine	147-149	interleukin 6	Mus musculus	59-63
18403737-7	2008	Compared with wild-type controls, brain infarction volumes 1 day and 14 days after transient focal cerebral ischemia were significantly reduced in Ngb-Tg mice.	Thioguanine	151-153	neuroglobin	Mus musculus	147-150
17980882-4	2008	Moreover, positive correlations were established between ABCA1-dependent efflux and the serum prebeta-HDL or TG concentrations.	Thioguanine	109-111	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	57-62
17999181-2	2008	In this study, we analyzed the levels of dopamine and its metabolites in the olfactory bulb (OB), and nigrostriatal regions of transgenic mice expressing human, mutant A53T alpha-synuclein (alpha-syn tg) and their non-transgenic (ntg) littermates using a sub-toxic, moderate dose of MPTP to determine if mutant human alpha-synuclein sensitizes the central dopaminergic systems to oxidative stress.	Thioguanine	200-202	synuclein alpha	Homo sapiens	173-188
18504197-7	2008	In the cancer patients, serum IL-18 was 90.668-/+20.363 pg/ml for TT-AA genotype, 119.641-/+15.338 pg/ml for GG-CC genotype, and 112.793-/+13.326 pg/ml for TG-AC genotype, showing significant differences (F=11.307, P=0.000).	Thioguanine	156-158	interleukin 18	Homo sapiens	30-35
18328815-9	2008	In subgroup analysis, subjects carrying the TG haplotype had significantly lower adiponectin concentrations than non-TG carriers in both normal weight (P&lt;0.001) and overweight-obese (P=0.009) subgroups.	Thioguanine	44-46	adiponectin, C1Q and collagen domain containing	Homo sapiens	81-92
17988843-6	2008	The enzymatic activity of the TPMT moiety was demonstrated by decreased sensitivity to 6-thioguanine and increased sensitivity to 6-mercaptopurine in HEK 293 cells expressing EGFP-TPMT.	Thioguanine	87-100	thiopurine S-methyltransferase	Homo sapiens	30-34
17999181-3	2008	We observed that after a single, sub-lethal MPTP injection, dopamine levels were reduced in striatum and SN in both the alpha-syn tg and ntg mice.	Thioguanine	130-132	synuclein, alpha	Mus musculus	120-129
18390703-8	2008	Further examination revealed that ICOSL expression of APCs was significantly suppressed in ICOS-Tg mice.	Thioguanine	96-98	icos ligand	Mus musculus	34-39
18390703-8	2008	Further examination revealed that ICOSL expression of APCs was significantly suppressed in ICOS-Tg mice.	Thioguanine	96-98	amyloid P component, serum	Mus musculus	54-58
18390703-8	2008	Further examination revealed that ICOSL expression of APCs was significantly suppressed in ICOS-Tg mice.	Thioguanine	96-98	inducible T cell co-stimulator	Mus musculus	34-38
18307789-1	2008	BACKGROUND: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported to be as closely correlated with insulin resistance as is the fasting serum insulin concentration (FSI), and therefore it is seen as a clinically useful way to identify the concomitant presence of insulin resistance and dyslipidemia.	Thioguanine	70-72	insulin	Homo sapiens	137-144
18381446-0	2008	Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy.	Thioguanine	66-79	mechanistic target of rapamycin kinase	Homo sapiens	0-29
18381446-0	2008	Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy.	Thioguanine	66-79	ribosomal protein S6 kinase B1	Homo sapiens	34-45
18381446-4	2008	To determine whether mTOR is involved in 6-TG-induced autophagy, we used rapamycin, a potential anticancer agent, to inhibit mTOR activity.	Thioguanine	41-45	mechanistic target of rapamycin kinase	Homo sapiens	21-25
18381446-6	2008	Consistently, short interfering RNA silencing of the 70-kDa ribosomal S6 kinase 1 (S6K1), the downstream effector of mTOR, markedly reduces 6-TG-induced autophagy.	Thioguanine	140-144	ribosomal protein S6 kinase A1	Homo sapiens	60-81
18381446-6	2008	Consistently, short interfering RNA silencing of the 70-kDa ribosomal S6 kinase 1 (S6K1), the downstream effector of mTOR, markedly reduces 6-TG-induced autophagy.	Thioguanine	140-144	ribosomal protein S6 kinase B1	Homo sapiens	83-87
18381446-6	2008	Consistently, short interfering RNA silencing of the 70-kDa ribosomal S6 kinase 1 (S6K1), the downstream effector of mTOR, markedly reduces 6-TG-induced autophagy.	Thioguanine	140-144	mechanistic target of rapamycin kinase	Homo sapiens	117-121
18381446-7	2008	Furthermore, we show that inhibition of mTOR by rapamycin induces the activation of Akt as shown by increased Akt phosphorylation at Ser(473) and the inhibition of 6-TG-induced apoptosis and cell death.	Thioguanine	164-168	mechanistic target of rapamycin kinase	Homo sapiens	40-44
18381446-7	2008	Furthermore, we show that inhibition of mTOR by rapamycin induces the activation of Akt as shown by increased Akt phosphorylation at Ser(473) and the inhibition of 6-TG-induced apoptosis and cell death.	Thioguanine	164-168	AKT serine/threonine kinase 1	Homo sapiens	84-87
18381446-9	2008	In conclusion, our data indicate that mTOR-S6K1 positively regulates autophagy after MMR processing of 6-TG probably through its negative feedback inhibition of Akt.	Thioguanine	103-107	mechanistic target of rapamycin kinase	Homo sapiens	38-42
18381446-9	2008	In conclusion, our data indicate that mTOR-S6K1 positively regulates autophagy after MMR processing of 6-TG probably through its negative feedback inhibition of Akt.	Thioguanine	103-107	ribosomal protein S6 kinase B1	Homo sapiens	43-47
18381446-9	2008	In conclusion, our data indicate that mTOR-S6K1 positively regulates autophagy after MMR processing of 6-TG probably through its negative feedback inhibition of Akt.	Thioguanine	103-107	AKT serine/threonine kinase 1	Homo sapiens	161-164
18325464-15	2008	Four weeks after BGP discontinuation Cr, TAN and TG content were restored to the normal levels while LV function, dimension, and mass were normalized.	Thioguanine	49-51	bone gamma-carboxyglutamate protein 2	Mus musculus	17-20
18029018-10	2008	Intercrossing hIL-4Ralpha Tg/mIL-4Ralpha(-/-) mice with mIL-4(-/-)/mIL-13(-/-) mice completely abrogated Type 2 responses in N. brasiliensis infections.	Thioguanine	26-28	interleukin 4 receptor	Homo sapiens	14-25
18247304-8	2008	CONCLUSION: These results suggest that the Arg16Gly polymorphism in beta2-adrenergic receptor gene are not only associated with serum TG,apoB100 and apoAII levels in the healthy Chinese subjects in Chengdu area, but also with serum TC and low-density lipoprotein cholesterol levels in subjects with endogenous hypertriglyceridemia.	Thioguanine	134-136	adrenoceptor beta 2	Homo sapiens	68-93
18788595-8	2008	The serum levels of TC (P &lt; 0.05), TG (P &lt; 0.05) and LDLC (P &lt; 0.05) in LDLR-/- mice were significantly higher than those in wild type mice with the same age.	Thioguanine	38-40	low density lipoprotein receptor	Mus musculus	81-85
18278185-8	2008	Also, a positive correlation was found between PAI-1 and TNFalpha levels, and relative BMI, HOMA-IR score, insulin, TG, HDL levels.	Thioguanine	116-118	serpin family E member 1	Homo sapiens	47-52
18247304-9	2008	The Arg16Gly polymorphism in beta2-adrenergic receptor gene may be associated with TG and/or cholesterol metabolism in Chinese Han population.	Thioguanine	83-85	adrenoceptor beta 2	Homo sapiens	29-54
18087549-9	2007	Adiponectin concentrations were correlated positively with high density lipoprotein cholesterol(HDL-C) and negatively with C-reactive protein and triglyceride(TG).	Thioguanine	159-161	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
17909095-9	2008	The action of ghrelin was attenuated in Pomc(-/-)Tg/+ mice, suggesting decreased sensitivity to additional orexigenic signals.	Thioguanine	49-51	pro-opiomelanocortin-alpha	Mus musculus	40-44
17909095-10	2008	However, AgRP induced delayed and long-lasting modifications of energy balance in Pomc(-/-)Tg/+, but not glucocorticoid-deficient Pomc(-/-) mice, by decreasing oxygen consumption, increasing the respiratory exchange ratio, and increasing food intake.	Thioguanine	91-93	agouti related neuropeptide	Mus musculus	9-13
17973864-18	2007	Both arterial GTPCH enzyme activity and BH(4) levels were significantly elevated in Tg-GCH mice compared with WT mice and basal NO release of the injured carotid artery tended to increase in Tg-GCH mice.	Thioguanine	84-86	GTP cyclohydrolase 1	Mus musculus	14-19
18087544-7	2007	CONCLUSION: The APOA5-1131T/C polymorphism has influence on serum TG level, and the APOA5-1131C allele is associated with the development of premature coronary heart disease in northern Chinese Han population.	Thioguanine	66-68	apolipoprotein A5	Homo sapiens	16-21
17973869-9	2007	Compared with the normal glucose tolerance (NGT) group, the T2DM group exhibited a higher distribution of the TG + GG genotype, G allele frequency and lower plasma adiponectin concentrations in TG + GG genotype carriers compared with those with the TT genotype.	Thioguanine	194-196	adiponectin, C1Q and collagen domain containing	Homo sapiens	164-175
17768309-1	2007	Apolipoprotein A5 (APOA5) gene variants were reported to be associated with two components of metabolic syndrome (MetS): higher TG levels and lower HDL levels.	Thioguanine	128-130	apolipoprotein A5	Homo sapiens	0-17
17222847-4	2007	In human studies, common APOA5 variants have shown near consistent association with elevated plasma TG levels, confirming apoAV as playing a role in human triglyceride metabolism.	Thioguanine	100-102	apolipoprotein A5	Homo sapiens	25-30
17768309-1	2007	Apolipoprotein A5 (APOA5) gene variants were reported to be associated with two components of metabolic syndrome (MetS): higher TG levels and lower HDL levels.	Thioguanine	128-130	apolipoprotein A5	Homo sapiens	19-24
18059582-1	2007	The objective of this cross-sectional study was to examine the relationship between the triglyceride-HDL-cholesterol ratio (TG:HDL-C) and insulin sensitivity in overweight and obese sedentary postmenopausal women.	Thioguanine	124-126	insulin	Homo sapiens	138-145
17917674-6	2007	Tethering of the subtelomere binding protein Tbf1 to the artificial telomere in tel1Delta cells restored preferential telomerase action at short telomeres; thus, Tbf1 might function in parallel to Tel1, which has a crucial role in a TG-repeat-controlled pathway for the activation of telomerase at short telomeres.	Thioguanine	233-235	Tbf1p	Saccharomyces cerevisiae S288C	45-49
17917674-6	2007	Tethering of the subtelomere binding protein Tbf1 to the artificial telomere in tel1Delta cells restored preferential telomerase action at short telomeres; thus, Tbf1 might function in parallel to Tel1, which has a crucial role in a TG-repeat-controlled pathway for the activation of telomerase at short telomeres.	Thioguanine	233-235	Tbf1p	Saccharomyces cerevisiae S288C	162-166
17917674-6	2007	Tethering of the subtelomere binding protein Tbf1 to the artificial telomere in tel1Delta cells restored preferential telomerase action at short telomeres; thus, Tbf1 might function in parallel to Tel1, which has a crucial role in a TG-repeat-controlled pathway for the activation of telomerase at short telomeres.	Thioguanine	233-235	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	197-201
17686921-6	2007	The induction of gene mutations was determined at the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene locus by selection with 6-thioguanine.	Thioguanine	137-150	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	54-100
17686921-6	2007	The induction of gene mutations was determined at the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene locus by selection with 6-thioguanine.	Thioguanine	137-150	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	102-106
17222847-4	2007	In human studies, common APOA5 variants have shown near consistent association with elevated plasma TG levels, confirming apoAV as playing a role in human triglyceride metabolism.	Thioguanine	100-102	apolipoprotein A5	Homo sapiens	122-127
17689519-6	2007	The CAD subjects with T2DM and ND patients carrying APOE-epsilon4 allele had lower plasma HDL-C level (p&lt;0.001), (p=0.008) but had higher plasma LDL-C (p=0.01), total cholesterol (p=0.002), (p=0.03) and TG (p&lt;0.001), (p=0.042) than that of the APOE-epsilon3 carriers, respectively.	Thioguanine	206-208	apolipoprotein E	Homo sapiens	52-56
17676721-2	2007	The calculated energies of the first allowed electronic transition decrease, and the nonresonant third-order polarizabilities at the THG, EFISHG, and DFWM optical processes increase progressively from [DBU-H+Br-.CBr(4) to [NPr(4)Br.CBr(4)] to [NMe(4)Br.CBr(4)].	Thioguanine	133-136	carbonyl reductase 4	Homo sapiens	212-218
17823980-6	2007	Immunoprecipitation and Western blot analyses demonstrate that c-Maf-c-Myb complex formation is enhanced among T cells from c-Maf Tg mice compared to non-Tg littermates following TCR engagement.	Thioguanine	130-132	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	63-68
17823980-6	2007	Immunoprecipitation and Western blot analyses demonstrate that c-Maf-c-Myb complex formation is enhanced among T cells from c-Maf Tg mice compared to non-Tg littermates following TCR engagement.	Thioguanine	130-132	myeloblastosis oncogene	Mus musculus	69-74
17823980-6	2007	Immunoprecipitation and Western blot analyses demonstrate that c-Maf-c-Myb complex formation is enhanced among T cells from c-Maf Tg mice compared to non-Tg littermates following TCR engagement.	Thioguanine	130-132	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	124-129
17823980-6	2007	Immunoprecipitation and Western blot analyses demonstrate that c-Maf-c-Myb complex formation is enhanced among T cells from c-Maf Tg mice compared to non-Tg littermates following TCR engagement.	Thioguanine	130-132	T cell receptor alpha variable 6-3	Mus musculus	179-182
17803909-4	2007	Deletion of Exo1 also ameliorated the induction of DNA damage checkpoints in response to gamma-irradiation and conferred cellular resistance to 6-thioguanine-induced DNA damage.	Thioguanine	144-157	exonuclease 1	Mus musculus	12-16
17452058-4	2007	Maximal exercise capacity was dramatically reduced in alpha2i TG mice, suggesting that AMPK alpha2 has a critical role in skeletal muscle during exercise.	Thioguanine	62-64	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	87-98
19547471-2	2007	In this study, we demonstrate that elastin is a major origin of the third-harmonic-generation (THG) contrast under Cr:forsterite laser excitation operating at 1230nm, with selective visualization inside many tissues such as lung tissues and arteries.	Thioguanine	95-98	elastin	Mus musculus	35-42
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Thioguanine	236-238	glutathione S-transferase theta 1	Homo sapiens	0-5
17916799-13	2007	Using this approach, we have measured the binding of Gag to d(TG)(10).	Thioguanine	62-64	Pr55(Gag)	Human immunodeficiency virus 1	53-56
17604218-6	2007	Activation of PPARalpha results in a reduction of plasma TG levels, which is achieved by: (1) induction of genes that decrease the availability of TG for hepatic VLDL secretion, and (2) induction of genes that promote lipoprotein lipase-mediated lipolysis of TG-rich plasma lipoproteins.	Thioguanine	57-59	peroxisome proliferator activated receptor alpha	Homo sapiens	14-23
17604218-6	2007	Activation of PPARalpha results in a reduction of plasma TG levels, which is achieved by: (1) induction of genes that decrease the availability of TG for hepatic VLDL secretion, and (2) induction of genes that promote lipoprotein lipase-mediated lipolysis of TG-rich plasma lipoproteins.	Thioguanine	57-59	lipoprotein lipase	Homo sapiens	218-236
17626270-4	2007	Expressions of NKG2D ligands (Rae-1 and Mult-1) in hepatocytes were markedly enhanced upon ConA stimulation in HBs-Tg mice, which greatly activated hepatic NK cells via NKG2D/Rae-1 or Mult-1 recognition.	Thioguanine	115-117	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	15-20
17626270-4	2007	Expressions of NKG2D ligands (Rae-1 and Mult-1) in hepatocytes were markedly enhanced upon ConA stimulation in HBs-Tg mice, which greatly activated hepatic NK cells via NKG2D/Rae-1 or Mult-1 recognition.	Thioguanine	115-117	ribonucleic acid export 1	Mus musculus	30-35
17626270-4	2007	Expressions of NKG2D ligands (Rae-1 and Mult-1) in hepatocytes were markedly enhanced upon ConA stimulation in HBs-Tg mice, which greatly activated hepatic NK cells via NKG2D/Rae-1 or Mult-1 recognition.	Thioguanine	115-117	UL16 binding protein 1	Mus musculus	40-46
17626270-4	2007	Expressions of NKG2D ligands (Rae-1 and Mult-1) in hepatocytes were markedly enhanced upon ConA stimulation in HBs-Tg mice, which greatly activated hepatic NK cells via NKG2D/Rae-1 or Mult-1 recognition.	Thioguanine	115-117	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	169-174
17651982-6	2007	TG accumulation was accompanied by overexpression of fatty acid synthase and adiponectin that are the downstream genes of sterol regulatory element binding protein-1 (SREBP-1), one of the key transcription factors in lipid homeostasis.	Thioguanine	0-2	fatty acid synthase	Mus musculus	53-72
17651982-6	2007	TG accumulation was accompanied by overexpression of fatty acid synthase and adiponectin that are the downstream genes of sterol regulatory element binding protein-1 (SREBP-1), one of the key transcription factors in lipid homeostasis.	Thioguanine	0-2	adiponectin, C1Q and collagen domain containing	Mus musculus	77-88
17651982-6	2007	TG accumulation was accompanied by overexpression of fatty acid synthase and adiponectin that are the downstream genes of sterol regulatory element binding protein-1 (SREBP-1), one of the key transcription factors in lipid homeostasis.	Thioguanine	0-2	sterol regulatory element binding transcription factor 1	Mus musculus	122-165
17651982-6	2007	TG accumulation was accompanied by overexpression of fatty acid synthase and adiponectin that are the downstream genes of sterol regulatory element binding protein-1 (SREBP-1), one of the key transcription factors in lipid homeostasis.	Thioguanine	0-2	sterol regulatory element binding transcription factor 1	Mus musculus	167-174
17493759-1	2007	Glutathione transferases (GSTs) catalyze the bioactivation of the thiopurine prodrugs azathioprine, cis-6-(2-acetylvinylthio)purine (cAVTP) and trans-6-(2-acetylvinylthio)guanine (tAVTG), thereby releasing the antimetabolites 6-mercaptopurine and 6-thioguanine.	Thioguanine	247-260	glutathione S-transferase kappa 1	Homo sapiens	26-30
17493759-1	2007	Glutathione transferases (GSTs) catalyze the bioactivation of the thiopurine prodrugs azathioprine, cis-6-(2-acetylvinylthio)purine (cAVTP) and trans-6-(2-acetylvinylthio)guanine (tAVTG), thereby releasing the antimetabolites 6-mercaptopurine and 6-thioguanine.	Thioguanine	247-260	suppressor of cytokine signaling 5	Homo sapiens	100-105
17526016-8	2007	The number and area of alpha-syn and palpha-syn, and the ratio of palpha-syn positive neurites were significantly higher in double Tg betaAPP(+)/PS(+) than in single Tg betaAPP(+)/PS(-) mouse brains in middle-aged and old groups.	Thioguanine	131-133	amyloid beta (A4) precursor protein	Mus musculus	134-141
17660728-10	2007	Furthermore, the plasmatic concentrations of IL-1beta, but not of CRP, negatively correlated with CHOL, LDLc, or TG levels and positively with those of CRP in T1D patients.	Thioguanine	113-115	interleukin 1 beta	Homo sapiens	45-53
17498780-6	2007	GSTT1 present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 micromol/mol creatinine, p=0.038), as well as in the case with UGT1A1 -3263T&gt;G TG/GG carriers (5.67 vs. 3.38 micromol/mol creatinine, p=0.001).	Thioguanine	236-238	aryl hydrocarbon receptor	Homo sapiens	114-117
17553475-12	2007	Ki67-positive cardiomyocytes were decreased in eNOS(-/-), but increased in eNOS-Tg and TIMP-3(-/-) hearts compared to WT controls.	Thioguanine	80-82	antigen identified by monoclonal antibody Ki 67	Mus musculus	0-4
17426439-4	2007	Our results show that MMR proteins (MLH1 or MSH2) are required for signaling to the autophagic pathway after exposure to 6-TG.	Thioguanine	121-125	mutL homolog 1	Homo sapiens	36-40
17634539-10	2007	Positive staining for MDM2 was detected in 2 of 15 (13%) TT genotype, 4 of 15 (26%) TG genotype, and 5 of 10 (50%) GG genotype carriers.	Thioguanine	84-86	MDM2 proto-oncogene	Homo sapiens	22-26
16777114-6	2007	Furthermore, the HTG population exhibited markedly elevated plasma apoAV levels that were positively correlated with serum TG levels.	Thioguanine	18-20	apolipoprotein A5	Homo sapiens	67-72
17374695-4	2007	These changes occurred in the absence of significant feeding differences in most groups, consistent with effects of Tg-MSH on energy expenditure and partitioning.	Thioguanine	116-118	msh homeobox 1	Mus musculus	119-122
17374695-5	2007	This is supported by indirect calorimetry studies demonstrating higher resting oxygen consumption and lower RQ in Tg-MSH mice on the HFD.	Thioguanine	114-116	msh homeobox 1	Mus musculus	117-120
17374695-7	2007	Histological and biochemical analyses revealed that hepatic fat accumulation was markedly reduced in Tg-MSH mice on the HFD.	Thioguanine	101-103	msh homeobox 1	Mus musculus	104-107
17426439-4	2007	Our results show that MMR proteins (MLH1 or MSH2) are required for signaling to the autophagic pathway after exposure to 6-TG.	Thioguanine	121-125	mutS homolog 2	Homo sapiens	44-48
17616687-0	2007	BRCA1 activates a G2-M cell cycle checkpoint following 6-thioguanine-induced DNA mismatch damage.	Thioguanine	55-68	BRCA1 DNA repair associated	Homo sapiens	0-5
17616687-6	2007	Additionally, the mutated BRCA1 results in an almost complete loss of a G(2)-M cell cycle checkpoint response induced by 6-TG.	Thioguanine	121-125	BRCA1 DNA repair associated	Homo sapiens	26-31
17616687-8	2007	Interestingly, ATR and Chk1 siRNA transfection in BRCA1-positive cells shows similar levels of 6-TG cytotoxicity as the control transfectant, whereas MSH2 and MLH1 siRNA transfectants show 6-TG resistance as expected.	Thioguanine	95-99	ATR serine/threonine kinase	Homo sapiens	15-18
17616687-8	2007	Interestingly, ATR and Chk1 siRNA transfection in BRCA1-positive cells shows similar levels of 6-TG cytotoxicity as the control transfectant, whereas MSH2 and MLH1 siRNA transfectants show 6-TG resistance as expected.	Thioguanine	95-99	checkpoint kinase 1	Homo sapiens	23-27
17616687-8	2007	Interestingly, ATR and Chk1 siRNA transfection in BRCA1-positive cells shows similar levels of 6-TG cytotoxicity as the control transfectant, whereas MSH2 and MLH1 siRNA transfectants show 6-TG resistance as expected.	Thioguanine	95-99	BRCA1 DNA repair associated	Homo sapiens	50-55
17616687-8	2007	Interestingly, ATR and Chk1 siRNA transfection in BRCA1-positive cells shows similar levels of 6-TG cytotoxicity as the control transfectant, whereas MSH2 and MLH1 siRNA transfectants show 6-TG resistance as expected.	Thioguanine	189-193	ATR serine/threonine kinase	Homo sapiens	15-18
17616687-8	2007	Interestingly, ATR and Chk1 siRNA transfection in BRCA1-positive cells shows similar levels of 6-TG cytotoxicity as the control transfectant, whereas MSH2 and MLH1 siRNA transfectants show 6-TG resistance as expected.	Thioguanine	189-193	checkpoint kinase 1	Homo sapiens	23-27
17616687-8	2007	Interestingly, ATR and Chk1 siRNA transfection in BRCA1-positive cells shows similar levels of 6-TG cytotoxicity as the control transfectant, whereas MSH2 and MLH1 siRNA transfectants show 6-TG resistance as expected.	Thioguanine	189-193	mutL homolog 1	Homo sapiens	159-163
17498224-6	2007	Four different NOD2/CARD15 haplotypes were observed in our population [CG(-): 89.8%, CGC: 3.5%, CC(-): 1.6%, TG(-): 5.1%].	Thioguanine	109-111	nucleotide binding oligomerization domain containing 2	Homo sapiens	15-19
17511860-0	2007	Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol.	Thioguanine	86-108	xanthine dehydrogenase	Mus musculus	27-43
17581062-4	2007	In going from the crossover temperature Tx approximately 1.2Tg to Tg, D(trans)eta/T increases by factors of 2.4+/-0.2 decades for rubrene, 3.4+/-0.2 decades for BPEA, and 3.8+/-0.4 decades for tetracene.	Thioguanine	60-62	endothelin receptor type A	Homo sapiens	78-81
17308000-6	2007	ACE2 inhibition (MLN-4760, 1 microM) significantly reduced ANG-(1-7) production by 83% (57 +/- 19 pM, P<0.01, n=7) in the Tg((+)) rats, whereas the inhibitor had no significant effect in the Tg((-)) rats (285 +/- 53 pM, P>0.05, n=10).	Thioguanine	122-124	angiotensin I converting enzyme 2	Rattus norvegicus	0-4
17308000-6	2007	ACE2 inhibition (MLN-4760, 1 microM) significantly reduced ANG-(1-7) production by 83% (57 +/- 19 pM, P<0.01, n=7) in the Tg((+)) rats, whereas the inhibitor had no significant effect in the Tg((-)) rats (285 +/- 53 pM, P>0.05, n=10).	Thioguanine	122-124	angiogenin	Rattus norvegicus	59-67
17308000-6	2007	ACE2 inhibition (MLN-4760, 1 microM) significantly reduced ANG-(1-7) production by 83% (57 +/- 19 pM, P<0.01, n=7) in the Tg((+)) rats, whereas the inhibitor had no significant effect in the Tg((-)) rats (285 +/- 53 pM, P>0.05, n=10).	Thioguanine	191-193	angiotensin I converting enzyme 2	Rattus norvegicus	0-4
17308000-7	2007	ACE2 activity was found in the effluent of perfused Tg((-)) and Tg((+)) hearts, and it was highly associated with ACE2 protein expression (r=0.78).	Thioguanine	52-54	angiotensin I converting enzyme 2	Rattus norvegicus	0-4
17308000-7	2007	ACE2 activity was found in the effluent of perfused Tg((-)) and Tg((+)) hearts, and it was highly associated with ACE2 protein expression (r=0.78).	Thioguanine	64-66	angiotensin I converting enzyme 2	Rattus norvegicus	0-4
17433263-1	2007	cis-6-(2-Acetylvinylthio)purine (cAVTP) and trans-6-(2-acetylvinylthio)guanine (tAVTG) are thiopurine prodrugs provisionally inactivated by an alpha,beta-unsaturated substituent on the sulfur of the parental thiopurines 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	248-261	suppressor of cytokine signaling 5	Homo sapiens	0-5
17433263-1	2007	cis-6-(2-Acetylvinylthio)purine (cAVTP) and trans-6-(2-acetylvinylthio)guanine (tAVTG) are thiopurine prodrugs provisionally inactivated by an alpha,beta-unsaturated substituent on the sulfur of the parental thiopurines 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	263-267	suppressor of cytokine signaling 5	Homo sapiens	0-5
17475219-5	2007	Importantly, cardioprotection mediated by ischemic preconditioning (IPC) was completely abolished in MMP-2 Tg hearts, as shown by abnormalities in mitochondrial ultrastructure and impaired respiration, increased lipid peroxidation, cell necrosis and persistently reduced recovery of contractile performance during post-ischemic reperfusion.	Thioguanine	107-109	matrix metallopeptidase 2	Mus musculus	101-106
17148505-5	2007	Thus, we have generated a leukaemic cell line (PreB697) and a normal human lymphoblastoid cell line (TK6) that are resistant to a pharmacologically relevant dose of MTX and show that while increased DHFR levels result in MTX resistance, the associated increased levels of MSH3 are insufficient to perturb MutSalpha functionality, in terms of MMR capacity or 6-thioguanine sensitivity.	Thioguanine	358-371	dihydrofolate reductase	Homo sapiens	199-203
17397871-8	2007	SF levels of MMP-3, TIMP-1, and MMP-3/TIMP-1 in TG were significantly higher than control, and the level of these biomarkers was significantly associated with the severity of the articular cartilage pathology.	Thioguanine	48-50	stromelysin-1	Oryctolagus cuniculus	13-18
17397871-8	2007	SF levels of MMP-3, TIMP-1, and MMP-3/TIMP-1 in TG were significantly higher than control, and the level of these biomarkers was significantly associated with the severity of the articular cartilage pathology.	Thioguanine	48-50	stromelysin-1	Oryctolagus cuniculus	32-37
17397871-8	2007	SF levels of MMP-3, TIMP-1, and MMP-3/TIMP-1 in TG were significantly higher than control, and the level of these biomarkers was significantly associated with the severity of the articular cartilage pathology.	Thioguanine	48-50	metalloproteinase inhibitor 1	Oryctolagus cuniculus	38-44
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	Thioguanine	320-322	nei like DNA glycosylase 1	Homo sapiens	47-53
17510427-0	2007	Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.	Thioguanine	98-109	thiopurine methyltransferase	Mus musculus	47-75
17376966-9	2007	In contrast, the numbers of activated microglia and levels of interleukin-6 were significantly reduced in minocycline-treated Tg-SwDI mice compared with saline-treated Tg-SwDI mice.	Thioguanine	126-128	interleukin 6	Mus musculus	62-75
17376589-3	2007	Our results demonstrate that Tg-LHbeta, but not LHRKO mice, show decreased Y-maze performance when compared to aged-matched wild-type animals.	Thioguanine	29-31	luteinizing hormone beta	Mus musculus	32-38
17088032-5	2007	The hypoxanthine uptake mediated by ENT2 was significantly reduced by the addition of 6-MP and 6-TG, and the inhibition of the hypoxanthine uptake by the 6-thiopurines was competitive.	Thioguanine	95-99	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	36-40
17088032-7	2007	The 6-MP uptake via ENT2 showed clear time- and substrate concentration-dependent profiles, and was inhibited by 6-TG in an inhibitor concentration-dependent fashion.	Thioguanine	113-117	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	20-24
17088032-9	2007	Therefore, we concluded that 6-MP and 6-TG, but not 5-FU, are transported mediated by the same recognition site on ENT2 with hypoxanthine.	Thioguanine	38-42	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	115-119
17040971-4	2007	p38 MAPK activation was earlier, more marked, and longer in the myocardium of the TG group compared with that of the nontransgenic (NTG) group after swimming stress, whereas JNK activation was detected on day 5 and decreased afterward.	Thioguanine	82-84	mitogen-activated protein kinase 14	Mus musculus	0-3
17040971-4	2007	p38 MAPK activation was earlier, more marked, and longer in the myocardium of the TG group compared with that of the nontransgenic (NTG) group after swimming stress, whereas JNK activation was detected on day 5 and decreased afterward.	Thioguanine	82-84	mitogen-activated protein kinase 1	Mus musculus	4-8
17040971-10	2007	Besides, treatment with a p38 MAPK inhibitor, FR-167653, resulted in regression of cardiac hypertrophy and fibrosis and improvement in the survival rate in the TG group.	Thioguanine	160-162	mitogen-activated protein kinase 14	Mus musculus	26-29
17040971-10	2007	Besides, treatment with a p38 MAPK inhibitor, FR-167653, resulted in regression of cardiac hypertrophy and fibrosis and improvement in the survival rate in the TG group.	Thioguanine	160-162	mitogen-activated protein kinase 1	Mus musculus	30-34
17380301-5	2007	Additionally, a multiple regression analysis indicates that among LDL, TG, HDL, total cholesterol, CRP, creatinine and glucose levels, the only variable significantly affecting p66((ShcA)) and PTX3 mRNA expressions either in adipose tissue or in WBCs is represented by the circulating amount of LDL.	Thioguanine	71-73	DNA polymerase delta 3, accessory subunit	Homo sapiens	177-180
17132823-8	2007	We conclude that these results show that GH-induced insulin resistance is associated with increased IMTG and unaltered VLDL-TG kinetics; we hypothesize that fat oxidation in muscle tissue is an important primary effect of GH and that circulating FFA rather than VLDL-TG constitute the major source for this process; and the role of IMTG in the development of GH-induced insulin resistance merits future research.	Thioguanine	102-104	insulin	Homo sapiens	52-59
17317843-0	2007	DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells.	Thioguanine	30-43	tumor protein p53	Homo sapiens	71-74
16804549-3	2007	Cerebral blood flow was determined in another transgenic mouse line that overexpresses human Epo in the brain only (tg-21): CBF increased by 17% compared with wt controls.	Thioguanine	116-118	erythropoietin	Homo sapiens	93-96
16804549-9	2007	Cerebral glucose metabolic rate may also be increased by a direct effect of Epo in the brain (tg-21 mice).	Thioguanine	94-96	erythropoietin	Mus musculus	76-79
17259238-5	2007	LDL-cholesterol (LDL-C) was calculated for samples with TG &lt; or =4.52 mmol/L RESULTS: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI).	Thioguanine	56-58	component of oligomeric golgi complex 2	Homo sapiens	0-15
17259238-5	2007	LDL-cholesterol (LDL-C) was calculated for samples with TG &lt; or =4.52 mmol/L RESULTS: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI).	Thioguanine	56-58	component of oligomeric golgi complex 2	Homo sapiens	17-22
17317843-1	2007	PURPOSE: We investigate the roles of DNA mismatch repair (MMR) and p53 in mediating the induction of autophagy in human tumor cells after exposure to 6-thioguanine (6-TG), a chemotherapy drug recognized by MMR.	Thioguanine	150-163	tumor protein p53	Homo sapiens	67-70
17317843-1	2007	PURPOSE: We investigate the roles of DNA mismatch repair (MMR) and p53 in mediating the induction of autophagy in human tumor cells after exposure to 6-thioguanine (6-TG), a chemotherapy drug recognized by MMR.	Thioguanine	165-169	tumor protein p53	Homo sapiens	67-70
17015055-0	2006	The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.	Thioguanine	73-84	thiopurine S-methyltransferase	Homo sapiens	4-32
17253762-6	2007	These self-associations restrict polymer chain motions, enhance biocompatibility, and lead to a higher Tg, which ensures that NREP does not become tacky in processes involving heat.	Thioguanine	103-105	neuronal regeneration related protein	Homo sapiens	126-130
18042314-18	2007	Using the multivariate linear regression models, we found that plasma leptin remained significantly associated with TG.	Thioguanine	116-118	leptin	Homo sapiens	70-76
17365914-6	2007	RESULTS: The distribution of GG, TG, and TT genotypes for eNOS gene was 48%, 33%, and 19% in PNE, compared with 61%, 26%, and 13% in the controls (p &gt; 0.05).	Thioguanine	33-35	nitric oxide synthase 3	Homo sapiens	58-62
17079459-6	2006	To resolve this apparent paradox, we examined the relationship between c-neu expression and estrogen/ERalpha-dependent cell proliferation in pubertal Tg (c-neu).	Thioguanine	150-152	erb-b2 receptor tyrosine kinase 2	Mus musculus	71-76
17079459-6	2006	To resolve this apparent paradox, we examined the relationship between c-neu expression and estrogen/ERalpha-dependent cell proliferation in pubertal Tg (c-neu).	Thioguanine	150-152	estrogen receptor 1 (alpha)	Mus musculus	101-108
17066413-0	2006	HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses.	Thioguanine	65-78	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-5
17066413-3	2006	Resistance to 6-thioguanine (6-TG) can be utilized to study mutational events at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus.	Thioguanine	14-27	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	134-139
17066413-3	2006	Resistance to 6-thioguanine (6-TG) can be utilized to study mutational events at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus.	Thioguanine	29-33	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	134-139
17066413-9	2006	HGPRT mutations were detected by selection with 6-TG.	Thioguanine	48-52	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-5
16488421-5	2007	In both groups, fasting C3 was strongly associated with fasting TG, TG-AUC, TG-dAUC and insulin sensitivity (HOMA) (R=0.68, 0.67, 0.41 and 0.67, respectively, for the whole group; P&lt;0.001 for each).	Thioguanine	64-66	complement C3	Homo sapiens	24-26
16849628-1	2006	Insulin is an important inhibitor of both hepatic glucose output and hepatic VLDL-triglyceride (VLDL-TG) production.	Thioguanine	101-103	CD320 antigen	Mus musculus	77-81
16849628-1	2006	Insulin is an important inhibitor of both hepatic glucose output and hepatic VLDL-triglyceride (VLDL-TG) production.	Thioguanine	101-103	CD320 antigen	Mus musculus	96-100
16849628-6	2006	We conclude that, compared with insulin sensitivity of hepatic glucose output, peripheral glucose uptake and hepatic VLDL-TG production are less sensitive to insulin.	Thioguanine	122-124	CD320 antigen	Mus musculus	117-121
17189541-8	2006	DISCUSSION: The present study suggests that antagonistic targeting of the histamine H(3) receptor decreases food intake, body weight, and plasma TG levels and, thus, represents an interesting approach to treatment of obesity and associated hyperlipidemia.	Thioguanine	145-147	histamine receptor H3	Rattus norvegicus	74-97
16442115-7	2006	Perilipin overexpression in macrophages with an expression vector resulted in significant lipid droplet formation and TG accumulation and this was unaffected by decreasing adipophilin levels using siRNA.	Thioguanine	118-120	perilipin 1	Homo sapiens	0-9
17253436-4	2006	Moreover, plasma adiponectin concentration is inversely associated with LDL-cholesterol, TG and is positively related to HDL-cholesterol.	Thioguanine	89-91	adiponectin, C1Q and collagen domain containing	Homo sapiens	17-28
17015055-13	2006	The association of lower TPMT activity with thioguanine-related liver damage could provide a means of identifying at-risk patients.	Thioguanine	44-55	thiopurine S-methyltransferase	Homo sapiens	25-29
16952134-3	2006	Substitution of guanine by hypoxanthine and 6-thioguanine resulted in activity similar to the unmodified parent molecule, whereas purine, 2-aminopurine, 2,6-diaminopurine, and 8-oxo-7,8-dihydroguanine substitution resulted in approximately 40-60 % reduction in activity, and 7-deazaguanine substitution led to the strongest (80 %) reduction in TLR9 stimulation.	Thioguanine	44-57	toll like receptor 9	Homo sapiens	344-348
16928383-6	2006	Phospho-Akt kinase activity increased (p&lt;0.05) in female TG after banding, but not in males.	Thioguanine	60-62	thymoma viral proto-oncogene 1	Mus musculus	8-11
17036413-4	2006	The TPMT activity of lysates was determined using 6-thioguanine as substrate with high-performance liquid chromatographic (HPLC) analysis and fluorimetric detection.	Thioguanine	50-63	thiopurine S-methyltransferase	Homo sapiens	4-8
16917760-10	2006	Glomerular upregulation of extracellular signal-regulated kinase, TGF-beta and extracellular matrix proteins was also significantly inhibited in diabetic BNP-Tg mice.	Thioguanine	158-160	transforming growth factor, beta 1	Mus musculus	66-74
16917760-10	2006	Glomerular upregulation of extracellular signal-regulated kinase, TGF-beta and extracellular matrix proteins was also significantly inhibited in diabetic BNP-Tg mice.	Thioguanine	158-160	natriuretic peptide type B	Mus musculus	154-157
16753018-8	2006	RESULTS: muCT analyses revealed a significant reduction in the trabecular bone of distal femur in MIF Tg at 8-12 weeks of age.	Thioguanine	102-104	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	98-101
17225873-5	2006	Until now, a test based on 6-thioguanine-resistant phenotype of HPRT mutant cells from LNS patients is the only method accepted for the diagnosis of any kind of mutation in carriers.	Thioguanine	27-40	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	64-68
16916326-5	2006	Administration of N(omega)-nitro-L-arginine methyl ester, a potent inhibitor of NO synthase, worsened the fibrotic response in bleomycin-treated eNOS-TG mice.	Thioguanine	150-152	nitric oxide synthase 3, endothelial cell	Mus musculus	145-149
16863620-8	2006	In multiple regression analysis abdominal obesity (p=0.001), TG (p=0.001) and glucose (p=0.02) were associated with CRP levels after correcting for other factors.	Thioguanine	61-63	C-reactive protein	Homo sapiens	116-119
16908954-5	2006	In multivariate analysis, RBP was accounted for by remnant-like particle-triglyceride (RLP-TG), interleukin 6, body mass index and low-density lipoprotein (LDL)-cholesterol (adjusted R2 = 0.621).	Thioguanine	91-93	retinol binding protein 4	Homo sapiens	26-29
16125709-4	2006	Further analysis defined four APOC3 SNPs and three APOA5 SNPs showing strong association with TG levels.	Thioguanine	94-96	apolipoprotein C3	Homo sapiens	30-35
16716965-10	2006	Furthermore, the patients in the TG group had a lower storage iron content (s-ferritin and s-iron saturation), lower s-vitamin D, higher s-PTH and homocysteine than the other groups.	Thioguanine	33-35	parathyroid hormone	Homo sapiens	139-142
16689761-8	2006	After elevation of both inhibitors their synergistic effect led to a stronger decrease of TG in FVIII-depleted neonatal plasma.	Thioguanine	90-92	coagulation factor VIII	Homo sapiens	96-101
16530731-8	2006	Taken together these results show that CNT3 and ENT2 play a key role in the transport of 6-MP and 6-TG by leukemia cells.	Thioguanine	98-102	solute carrier family 28 member 3	Homo sapiens	39-43
16530731-8	2006	Taken together these results show that CNT3 and ENT2 play a key role in the transport of 6-MP and 6-TG by leukemia cells.	Thioguanine	98-102	solute carrier family 29 member 2	Homo sapiens	48-52
16446124-6	2006	In contrast, hNeil1 released Tg non-stereoselectively, but the rate of excision was much greater when Tg opposed guanine.	Thioguanine	29-31	nei like DNA glycosylase 1	Homo sapiens	13-19
16125709-4	2006	Further analysis defined four APOC3 SNPs and three APOA5 SNPs showing strong association with TG levels.	Thioguanine	94-96	apolipoprotein A5	Homo sapiens	51-56
16711598-5	2006	In contrast to the significantly elevated lipid levels in ZDF rats fed the CON diet, concentrations of plasma FFA and TG in ZDF rats fed CLA and TZD diets were normalized.	Thioguanine	118-120	clasper	Mus musculus	137-140
16487444-16	2006	Serum TG levels were inversely correlated with plasma activities of factors V, VII, VIII, IX, X and vWF (r: -0.83, P &lt; 0.001; r: -0.68, P &lt; 0.05; r: -0.61, P &lt; 0.05; r: -0.77, P &lt; 0.01; r: -0.63, P &lt; 0.05; r: -0.60, P &lt; 0.05, respectively).	Thioguanine	6-8	cytochrome c oxidase subunit 8A	Homo sapiens	84-88
16487444-16	2006	Serum TG levels were inversely correlated with plasma activities of factors V, VII, VIII, IX, X and vWF (r: -0.83, P &lt; 0.001; r: -0.68, P &lt; 0.05; r: -0.61, P &lt; 0.05; r: -0.77, P &lt; 0.01; r: -0.63, P &lt; 0.05; r: -0.60, P &lt; 0.05, respectively).	Thioguanine	6-8	von Willebrand factor	Homo sapiens	100-103
16487444-19	2006	Also, in patients with SHypo, serum TG levels were positively correlated with serum TSH levels (r: 0.42, P &lt; 0.05), plasma activities of factors V, VII and X (r: 0.42, P &lt; 0.05; r: 0.54, P &lt; 0.01; r: 0.57, P &lt; 0.01, respectively) and negatively correlated with plasma fibrinogen levels (r: -0.41, P &lt; 0.05).	Thioguanine	36-38	fibrinogen beta chain	Homo sapiens	280-290
16711598-7	2006	Although ZDF CON rats developed significant hepatic steatosis, both CLA- and TZD-fed rats had hepatic TG levels similar to those of lean rats.	Thioguanine	102-104	clasper	Mus musculus	68-71
18666383-1	2006	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP), thioguanine and azathioprine (AZA).	Thioguanine	117-128	thiopurine S-methyltransferase	Homo sapiens	0-28
16293269-4	2006	Mutation induction at the HPRT locus was detected to measure 6-thioguanine-resistant clones.	Thioguanine	61-74	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	26-30
16571847-5	2006	These findings are consistent with adiponectin promoting lipid uptake and subsequent oxidation in muscle and inhibiting TG synthesis in the liver.	Thioguanine	120-122	adiponectin, C1Q and collagen domain containing	Homo sapiens	35-46
16407649-5	2006	The plasma leptin was lower in the SL-DG group than in the DG group, plus a lower plasma TG level was accompanied by an increase in adipocyte LPL activity.	Thioguanine	89-91	lipoprotein lipase	Rattus norvegicus	142-145
18666383-1	2006	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP), thioguanine and azathioprine (AZA).	Thioguanine	117-128	thiopurine S-methyltransferase	Homo sapiens	30-34
16195314-6	2005	Mutagenicity at the hypoxanthine (guanine) phosphoribosyltransferase (hprt) locus was measured by selection with 6-thioguanine.	Thioguanine	113-126	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	20-68
16555470-19	2006	However, the 9c,11t CLA isomer did appear to lower plasma TG and glucose concentrations compared with the 10t,12c CLA isomer.	Thioguanine	58-60	selectin P ligand	Homo sapiens	20-23
16306365-8	2005	Expression of lipoprotein lipase 1, carnitine palmitoyl transferase 1b, and 3-hydroxyacyl-CoA dehydrogenase was increased in Tg-Prkag3(225Q) mice, with opposing effects in Prkag3-/- mice after exercise.	Thioguanine	125-127	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	Mus musculus	128-134
16306365-8	2005	Expression of lipoprotein lipase 1, carnitine palmitoyl transferase 1b, and 3-hydroxyacyl-CoA dehydrogenase was increased in Tg-Prkag3(225Q) mice, with opposing effects in Prkag3-/- mice after exercise.	Thioguanine	125-127	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	Mus musculus	172-178
16155002-8	2005	In maternal 14-day post-conception Tg-UGT1mice, liver UGT1A1, UGT1A4, and UGT1A6 were induced, with the levels returning to near normal by birth.	Thioguanine	35-37	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	54-60
16378107-9	2005	In female twins, univariate and multivariate association analyses showed that the 447X allele was associated with the 12.9% decrease of TG and 2.7 mm Hg (1 mm Hg=0.133 kPa) decrease of SBP, 1.8 mm Hg decrease of DBP.	Thioguanine	136-138	D-box binding PAR bZIP transcription factor	Homo sapiens	212-215
16477805-5	2005	The Framingham Study reaffirms the significant linear risk factor trends across fibrinogen tertiles (P&lt; 0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and TG in both sexes.	Thioguanine	208-210	fibrinogen beta chain	Homo sapiens	80-90
16188896-3	2005	We hypothesized lower angiotensin II (Ang II) sensitivity of afferent arterioles in ET-1 tg.	Thioguanine	89-91	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	22-36
16188896-3	2005	We hypothesized lower angiotensin II (Ang II) sensitivity of afferent arterioles in ET-1 tg.	Thioguanine	89-91	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	38-44
16195314-6	2005	Mutagenicity at the hypoxanthine (guanine) phosphoribosyltransferase (hprt) locus was measured by selection with 6-thioguanine.	Thioguanine	113-126	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	70-74
16181300-1	2005	BACKGROUND: In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive tioguanine (thioguanine) metabolites.	Thioguanine	250-260	thiopurine S-methyltransferase	Homo sapiens	101-131
16257981-4	2005	NMR experiments clearly indicate that [d(TG(Me)GGT)]4 possesses a G(Me)-tetrad with all dG(Me) residues in a syn-glycosidic conformation while an anti-arrangement is apparent for the four dG(Me) of [d(TGG(Me)GT)]4.	Thioguanine	41-43	synemin	Homo sapiens	109-112
16181300-1	2005	BACKGROUND: In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive tioguanine (thioguanine) metabolites.	Thioguanine	250-260	thiopurine S-methyltransferase	Homo sapiens	133-137
16181300-1	2005	BACKGROUND: In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive tioguanine (thioguanine) metabolites.	Thioguanine	262-273	thiopurine S-methyltransferase	Homo sapiens	101-131
16181300-1	2005	BACKGROUND: In vitro studies suggest interactions between mesalazine (mesalamine) and thiopurines by thiopurine S-methyltransferase (TPMT) inhibition, influencing the balance of hepatotoxic 6-methylmercaptopurine ribonucleotide and immunosuppressive tioguanine (thioguanine) metabolites.	Thioguanine	262-273	thiopurine S-methyltransferase	Homo sapiens	133-137
16202923-7	2005	One of these is the application of a specific PGF2alpha receptor blocker, Theratechnologies (THG)113.31.	Thioguanine	93-96	prostaglandin F2-alpha receptor	Ovis aries	46-64
15979786-8	2005	The synthesized CL-20 and its precursors have also been subjected to hyphenated TG-FTIR studies to understand decomposition pattern.	Thioguanine	80-82	epithelial membrane protein 1	Homo sapiens	16-21
16379285-2	2005	HO2 x CH3 OH (Thr = DL-Threonine, Phen = o-Phenanthroline), which has not been published, was synthesized and characterized by elemental analysis, IR spectroscopy, and TG-DTA.	Thioguanine	168-170	heme oxygenase 2	Homo sapiens	0-3
16245689-5	2005	A reliable correlation was found between the population of the semifolded (tg-) conformation of the choline moiety of substrate molecules and the rate of their BChE hydrolysis.	Thioguanine	75-77	butyrylcholinesterase	Homo sapiens	160-164
16175140-1	2005	Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN).	Thioguanine	68-81	thiopurine S-methyltransferase	Homo sapiens	170-198
16175140-1	2005	Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN).	Thioguanine	68-81	thiopurine S-methyltransferase	Homo sapiens	200-204
16039291-6	2005	The B1 homozygotes for CETP Taq1B genotype showed significant reduction in TC (-0.25+/-0.07, p &lt; 0.01), LDL-C (-0.15+/-0.06, p &lt; 0.050) and TG (-0.20+/-0.08, p &lt; 0.05).	Thioguanine	146-148	cholesteryl ester transfer protein	Homo sapiens	23-27
15985490-1	2005	OBJECTIVE: Elevation of free fatty acids (FFAs) by the infusion of triglyceride-heparin emulsion infusion (TG-Hep) causes insulin resistance (IR).	Thioguanine	107-109	insulin	Homo sapiens	122-129
15985490-10	2005	CONCLUSIONS: We conclude that rosiglitazone: 1) causes a significant increase in GIR; 2) induces a decrease in inflammatory mediators, C-reactive protein, and serum amyloid A; 3) decreases the rise in FFAs and triglycerides after TG-Hep infusion; and 4) does not prevent FFA-induced IR.	Thioguanine	230-232	C-reactive protein	Homo sapiens	135-177
16044099-1	2005	Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	130-143	thiopurine S-methyltransferase	Homo sapiens	0-30
15918673-4	2005	Our analysis of MD and crystal structures shows that BII conformation is sequence specific and dinucleotides GC, CG, CA, TG, TA show high preference to take up BII conformation, while TT, TC, CT, CC dinucleotides rarely take up this conformation.	Thioguanine	121-123	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	53-56
15918673-4	2005	Our analysis of MD and crystal structures shows that BII conformation is sequence specific and dinucleotides GC, CG, CA, TG, TA show high preference to take up BII conformation, while TT, TC, CT, CC dinucleotides rarely take up this conformation.	Thioguanine	121-123	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	160-163
15918673-10	2005	In conformity with the sequence preference seen for dinucleotides in each strand, BII.BII combination of backbone conformation was observed only for GC, CG, CA, and TG containing dinucleotide steps.	Thioguanine	165-167	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	82-85
15918673-10	2005	In conformity with the sequence preference seen for dinucleotides in each strand, BII.BII combination of backbone conformation was observed only for GC, CG, CA, and TG containing dinucleotide steps.	Thioguanine	165-167	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	86-89
16044099-1	2005	Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	130-143	thiopurine S-methyltransferase	Homo sapiens	32-36
15897017-5	2005	We therefore, established an optimized and fast isocratic HPLC linked TPMT assay based on the enzymatic methylation of mercaptopurine or thioguanine in RBC lysates with S-adenosyl-l-methionine as methyl donor.	Thioguanine	137-148	thiopurine S-methyltransferase	Homo sapiens	70-74
15905592-3	2005	administration of TNF-alpha-treated, semimature DCs pulsed with thyrogloblin (Tg), but not with OVA Ag, inhibits the subsequent development of Tg-induced experimental autoimmune thyroiditis (EAT) in CBA/J mice.	Thioguanine	78-80	tumor necrosis factor	Mus musculus	18-27
15914117-9	2005	CONCLUSION: Blockade of NF-kappaB activation did not ameliorate myocardial inflammation but improved cardiac function and survival in male TNF-alpha TG mice.	Thioguanine	149-151	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-33
15914117-9	2005	CONCLUSION: Blockade of NF-kappaB activation did not ameliorate myocardial inflammation but improved cardiac function and survival in male TNF-alpha TG mice.	Thioguanine	149-151	tumor necrosis factor	Mus musculus	139-148
15817670-11	2005	A pharmacokinetic study revealed that the clearance of iv administrated [(3)H]estradiol was markedly enhanced in Tg-CYP3A4 mice compared with wild-type mice.	Thioguanine	113-115	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	116-122
15943548-1	2005	The drug-metabolizing enzyme thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurines such as 6-mercaptopurine, 6-thioguanine, and azathiopurine, which are used as immunosuppressants and in the treatment of acute lymphoblastic leukemia and rheumatoid arthritis.	Thioguanine	136-149	thiopurine S-methyltransferase	Homo sapiens	29-59
15943548-1	2005	The drug-metabolizing enzyme thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurines such as 6-mercaptopurine, 6-thioguanine, and azathiopurine, which are used as immunosuppressants and in the treatment of acute lymphoblastic leukemia and rheumatoid arthritis.	Thioguanine	136-149	thiopurine S-methyltransferase	Homo sapiens	61-65
16034719-5	2005	In the GDM group TNF-alpha concentrations correlated significantly with sTNFR-1 (r = 0.444, p = 0.00008), sTNFR-2 (r = 0.364, p = 0.0016) and with C-peptide concentrations (r = 0.318, p = 0.016), whereas in women with NGT TNF-alpha correlated only with TG levels (r = 0.50, p = 0.024).	Thioguanine	253-255	tumor necrosis factor	Homo sapiens	17-26
16034719-7	2005	TG concentrations as well as BMI before pregnancy and at the time of sampling in pregnant NGT women were significant predictors, explaining 62% of the variance in TNF-alpha concentration.	Thioguanine	0-2	tumor necrosis factor	Homo sapiens	163-172
16034719-8	2005	There were also negative correlations between adiponectin concentrations and a pregestational BMI (r = - 0.298, p = 0.009), BMI at the time of sampling (r = - 0.239, p = 0.034) and TG concentrations (r = - 0.379, p = 0.039) in GDM patients, whereas women with NGT showed only a negative correlation between adiponectin and TG concentrations (r = - 0.488, p = 0.025).	Thioguanine	181-183	adiponectin, C1Q and collagen domain containing	Homo sapiens	46-57
16034719-8	2005	There were also negative correlations between adiponectin concentrations and a pregestational BMI (r = - 0.298, p = 0.009), BMI at the time of sampling (r = - 0.239, p = 0.034) and TG concentrations (r = - 0.379, p = 0.039) in GDM patients, whereas women with NGT showed only a negative correlation between adiponectin and TG concentrations (r = - 0.488, p = 0.025).	Thioguanine	323-325	adiponectin, C1Q and collagen domain containing	Homo sapiens	46-57
15905592-3	2005	administration of TNF-alpha-treated, semimature DCs pulsed with thyrogloblin (Tg), but not with OVA Ag, inhibits the subsequent development of Tg-induced experimental autoimmune thyroiditis (EAT) in CBA/J mice.	Thioguanine	143-145	tumor necrosis factor	Mus musculus	18-27
15905592-6	2005	Prior adoptive transfer of the same CD4(+)CD25(+) Treg cells into CBA/J hosts suppressed Tg-induced EAT.	Thioguanine	89-91	CD4 antigen	Mus musculus	36-39
15971422-11	2005	Mean ratio of articular nitrotyrosine-tyrosine (+/- SEM) was increased in the XOR-inactivated group, compared with controls: 12.3 +/- 0.7, 9.6 +/- 0.8 and 10.4 +/- 0.5 pg/microg in TG, SG and AG, respectively; p &lt; 0.05, TG vs SG.	Thioguanine	181-183	xanthine dehydrogenase	Rattus norvegicus	78-81
15882265-5	2005	By day 14, the expression of two normal tubular proteins, E-cadherin and Ksp-cadherin, were significantly lower in the PAI-1 tg mice (3.2 +/- 0.5% vs. 11.7 +/- 5.9% and 2.6 +/- 1.6) vs. 6.2 +/- 0.8%, respectively), implying more extensive tubular damage.	Thioguanine	125-127	cadherin 1	Mus musculus	58-68
15882265-5	2005	By day 14, the expression of two normal tubular proteins, E-cadherin and Ksp-cadherin, were significantly lower in the PAI-1 tg mice (3.2 +/- 0.5% vs. 11.7 +/- 5.9% and 2.6 +/- 1.6) vs. 6.2 +/- 0.8%, respectively), implying more extensive tubular damage.	Thioguanine	125-127	cadherin 16	Mus musculus	73-85
15882265-5	2005	By day 14, the expression of two normal tubular proteins, E-cadherin and Ksp-cadherin, were significantly lower in the PAI-1 tg mice (3.2 +/- 0.5% vs. 11.7 +/- 5.9% and 2.6 +/- 1.6) vs. 6.2 +/- 0.8%, respectively), implying more extensive tubular damage.	Thioguanine	125-127	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	119-124
15952115-7	2005	CONCLUSION: apoA5 - 1131T &gt; C polymorphism is associated with an increased risk of CAD and is also in strong association with serum TG levels.	Thioguanine	135-137	apolipoprotein A5	Homo sapiens	12-17
15657916-3	2005	Intratracheal injection of B[a]P resulted in a statistically significant and dose-dependent increase in gpt mutant frequency as measured by 6-thioguanine selection.	Thioguanine	140-153	glutamic pyruvic transaminase, soluble	Mus musculus	104-107
15777558-10	2005	These findings suggest that the mechanism of the previously described association with plasma TG is, at least in part, related to the correlation of the polymorphism with the level of expression of apoC-I.	Thioguanine	94-96	apolipoprotein C1	Homo sapiens	198-204
15897250-5	2005	In 3-day cytotoxicity assays, MRP5-transfected cells were approximately 9-fold resistant to 5-FU and 6-thioguanine.	Thioguanine	101-114	ATP binding cassette subfamily C member 5	Homo sapiens	30-34
15814669-7	2005	Ganp(Tg) also generated exceptionally high-affinity anti-HIV-1 (V3 peptide) mAbs (K(D) &gt; 9.90 x 10(-11) M) with neutralizing activity.	Thioguanine	5-7	minichromosome maintenance complex component 3 associated protein	Mus musculus	0-4
15748599-11	2005	On the other hand, apo-AI contents of prebeta(1)-HDL and HDL(3a) were significantly higher, while HDL(2a) and HDL(2b) were significantly lower in high TG and very high TG subgroup vs. normal TG subgroup within either TC desirable or TC high subjects.	Thioguanine	151-153	apolipoprotein A1	Homo sapiens	19-25
15748599-11	2005	On the other hand, apo-AI contents of prebeta(1)-HDL and HDL(3a) were significantly higher, while HDL(2a) and HDL(2b) were significantly lower in high TG and very high TG subgroup vs. normal TG subgroup within either TC desirable or TC high subjects.	Thioguanine	168-170	apolipoprotein A1	Homo sapiens	19-25
15748599-11	2005	On the other hand, apo-AI contents of prebeta(1)-HDL and HDL(3a) were significantly higher, while HDL(2a) and HDL(2b) were significantly lower in high TG and very high TG subgroup vs. normal TG subgroup within either TC desirable or TC high subjects.	Thioguanine	168-170	apolipoprotein A1	Homo sapiens	19-25
15389567-10	2005	However, apoB48 preferentially bound to newly synthesized TG in the presence of micelles, accounting in part for the functional advantage of apoB editing in the intestine.	Thioguanine	58-60	apolipoprotein B	Homo sapiens	9-15
15788687-6	2005	RESULTS: Transfection of small interfering RNA against the CK2 alpha and/or alpha" catalytic subunits results in marked apoptosis of HeLa cells following treatment with 6-TG.	Thioguanine	169-173	casein kinase 2 alpha 2	Homo sapiens	59-68
15788687-10	2005	CK2 alpha relocalizes to the endoplasmic reticulum after 6-TG treatment.	Thioguanine	57-61	casein kinase 2 alpha 2	Homo sapiens	0-9
15788687-11	2005	Additionally, transfection of Cdc2 with a mutation at Ser(39) to Ala, which is the CK2 phosphorylation site, partially inhibits cell cycle progression in G(1) to G(2) phase following 6-TG treatment.	Thioguanine	183-187	cyclin dependent kinase 1	Homo sapiens	30-34
15733886-4	2005	RESULTS: The HDL2/HDL3 ratio had a strong negative correlation with TG (r=-0.272, P&lt;0.0001 and r=-0.314, P&lt;0.0001) in both pre- and postmenopausal women.	Thioguanine	68-70	junctophilin 3	Homo sapiens	13-17
15733886-4	2005	RESULTS: The HDL2/HDL3 ratio had a strong negative correlation with TG (r=-0.272, P&lt;0.0001 and r=-0.314, P&lt;0.0001) in both pre- and postmenopausal women.	Thioguanine	68-70	HDL3	Homo sapiens	18-22
15389567-10	2005	However, apoB48 preferentially bound to newly synthesized TG in the presence of micelles, accounting in part for the functional advantage of apoB editing in the intestine.	Thioguanine	58-60	apolipoprotein B	Homo sapiens	9-13
15924804-7	2005	The APOA5-1131C allele also showed a correlation with increasing plasma TG levels (P &lt; 0.01).	Thioguanine	72-74	apolipoprotein A5	Homo sapiens	4-9
15756213-9	2005	LDLs from patients with PFIC had high TG contents and exhibited high abilities to transform macrophages into foam cells.	Thioguanine	38-40	ATPase phospholipid transporting 8B1	Homo sapiens	24-28
15884766-8	2005	In hamsters supplemented with DAPP 1.4%, plasma TG concentrations were 45% lower (P= 0.018) than in cholesterol-control-fed hamsters, whereas no such beneficial effect was observed in the free stanol group.	Thioguanine	48-50	dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide	Mesocricetus auratus	30-36
15733036-4	2005	Delayed HPRT(-) mutations, which are indications of genomic instability, were detected by incubating the cells in medium containing aminopterin, selectively killing HPRT(-) mutants, and then treating the cells with medium containing 6-thioguanine, which selectively killed non-mutant cells.	Thioguanine	233-246	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	8-12
15482260-2	2005	LPL (lipoprotein lipase) is one of the key enzymes in the metabolism of the TG-rich lipoproteins which hydrolyses TG from the chylomicrons and very-LDL (low-density lipoprotein).	Thioguanine	76-78	lipoprotein lipase	Homo sapiens	0-3
15482260-2	2005	LPL (lipoprotein lipase) is one of the key enzymes in the metabolism of the TG-rich lipoproteins which hydrolyses TG from the chylomicrons and very-LDL (low-density lipoprotein).	Thioguanine	76-78	lipoprotein lipase	Homo sapiens	5-23
15482260-3	2005	To investigate the relationship between the LPL gene and lipid profiles, especially TG, in 148 hypertensive families, we have chosen seven flanking microsatellite markers and four internal markers of the LPL gene and conducted linkage analysis by SOLAR and S.A.G.E.	Thioguanine	84-86	lipoprotein lipase	Homo sapiens	44-47
15482260-11	2005	The present study in the Chinese families with hypertension suggested that the LPL gene might influence lipid levels, especially TG metabolism.	Thioguanine	129-131	lipoprotein lipase	Homo sapiens	79-82
15924804-8	2005	CONCLUSIONS: The APOA5-1131T/C polymorphism but not APOC3-482C/T might contribute to an increased risk of CAD among Chinese accompanied by an elevation of serum TG levels; this effect was found to be independent of the APOC3-482C/T variant.	Thioguanine	161-163	apolipoprotein A5	Homo sapiens	17-22
15730804-7	2004	Multiple logistic regression analysis showed that the AA genotype of THBS-1 gene G1678A carriers had a higher risk of cerebral thrombosis (OR: 1.4; 95% CI 1.083 - 1.693; P = 0.008) after adjustment for age, sex, SBP, DBP, BMI, smoking, TC, TG, HDL-C, LDL-C and Glu.	Thioguanine	240-242	thrombospondin 1	Homo sapiens	69-75
15759455-8	2005	Maximal activity of ACE is observed in TC 9.41 mM/l and TG concentration 3.05 mM/l.	Thioguanine	56-58	angiotensin I converting enzyme	Homo sapiens	20-23
15857307-11	2005	Although these actions are not primary targets of the compounds discussed here, it is interesting that drugs inducing the LDL-R usually also lower TG and, in the case of HMGRI, increase HDL-C.	Thioguanine	147-149	low density lipoprotein receptor	Homo sapiens	122-127
15502220-2	2005	The assay is based on a mitogen- and growth factor-dependent clonal expansion of peripheral T lymphocytes in which the 6-thioguanine-resistant HPRT mutants can be selected, enumerated, and collected for molecular analysis of their mutational nature.	Thioguanine	119-132	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	143-147
15646804-2	2004	To establish the formation of Tg multimers, the partially unfolded/reduced Tg or deoxycholate-treated/ reduced Tg was subjected to protein disulfide isomerase (PDI)-mediated multimerization.	Thioguanine	75-77	prolyl 4-hydroxylase subunit beta	Bos taurus	131-158
15646804-2	2004	To establish the formation of Tg multimers, the partially unfolded/reduced Tg or deoxycholate-treated/ reduced Tg was subjected to protein disulfide isomerase (PDI)-mediated multimerization.	Thioguanine	75-77	prolyl 4-hydroxylase subunit beta	Bos taurus	160-163
15646804-2	2004	To establish the formation of Tg multimers, the partially unfolded/reduced Tg or deoxycholate-treated/ reduced Tg was subjected to protein disulfide isomerase (PDI)-mediated multimerization.	Thioguanine	75-77	prolyl 4-hydroxylase subunit beta	Bos taurus	131-158
15646804-2	2004	To establish the formation of Tg multimers, the partially unfolded/reduced Tg or deoxycholate-treated/ reduced Tg was subjected to protein disulfide isomerase (PDI)-mediated multimerization.	Thioguanine	75-77	prolyl 4-hydroxylase subunit beta	Bos taurus	160-163
15646804-3	2004	Oxidized glutathione/PDI-mediated formation of multimeric Tg forms, requiring at least an equivalent molar ratio of PDI/Tg monomer, decreased with increasing concentration of reduced glutathione (GSH), suggesting the oxidizing role of PDI.	Thioguanine	58-60	prolyl 4-hydroxylase subunit beta	Bos taurus	21-24
15646804-3	2004	Oxidized glutathione/PDI-mediated formation of multimeric Tg forms, requiring at least an equivalent molar ratio of PDI/Tg monomer, decreased with increasing concentration of reduced glutathione (GSH), suggesting the oxidizing role of PDI.	Thioguanine	58-60	prolyl 4-hydroxylase subunit beta	Bos taurus	116-119
15646804-3	2004	Oxidized glutathione/PDI-mediated formation of multimeric Tg forms, requiring at least an equivalent molar ratio of PDI/Tg monomer, decreased with increasing concentration of reduced glutathione (GSH), suggesting the oxidizing role of PDI.	Thioguanine	58-60	prolyl 4-hydroxylase subunit beta	Bos taurus	116-119
15646804-3	2004	Oxidized glutathione/PDI-mediated formation of multimeric Tg forms, requiring at least an equivalent molar ratio of PDI/Tg monomer, decreased with increasing concentration of reduced glutathione (GSH), suggesting the oxidizing role of PDI.	Thioguanine	120-122	prolyl 4-hydroxylase subunit beta	Bos taurus	21-24
15646804-5	2004	Independently, the exposure of partially unfolded Tg to GSH resulted in Tg multimerization, enhanced by PDI, according to thiol-disulfide exchange.	Thioguanine	50-52	prolyl 4-hydroxylase subunit beta	Bos taurus	104-107
15646804-9	2004	Present results suggest that the oxidase as well as isomerase function of PDI may be involved in the multimerization of partially unfolded Tg or deoxycholate-treated Tg.	Thioguanine	139-141	prolyl 4-hydroxylase subunit beta	Bos taurus	74-77
15646804-9	2004	Present results suggest that the oxidase as well as isomerase function of PDI may be involved in the multimerization of partially unfolded Tg or deoxycholate-treated Tg.	Thioguanine	166-168	prolyl 4-hydroxylase subunit beta	Bos taurus	74-77
15645646-9	2004	CONCLUSION: Alcoholics with homozygous (TG)11 alleles in intron 8 of the CFTR gene appear to be protected against decreased MBC, compared with those who have the (TG)11/(TG)12 and (TG)12/(TG)12 genotypes, suggesting a role for CFTR gene polymorphism in the progression of alcohol-related pancreatic disease.	Thioguanine	40-42	CF transmembrane conductance regulator	Homo sapiens	73-77
15545516-6	2004	In addition, both the gene expression and zymographic activity of MMP-9, but not MMP-2, were significantly higher in BNP-Tg than non-Tg mice.	Thioguanine	121-123	matrix metallopeptidase 9	Mus musculus	66-71
15545516-6	2004	In addition, both the gene expression and zymographic activity of MMP-9, but not MMP-2, were significantly higher in BNP-Tg than non-Tg mice.	Thioguanine	121-123	natriuretic peptide type B	Mus musculus	117-120
15545516-6	2004	In addition, both the gene expression and zymographic activity of MMP-9, but not MMP-2, were significantly higher in BNP-Tg than non-Tg mice.	Thioguanine	133-135	matrix metallopeptidase 9	Mus musculus	66-71
15858385-3	2004	Mutation induction in hprt locus was detected to measure 6-thioguanine resistant colonies and deletion spectrum of exons was analyzed by multiplex PCR.	Thioguanine	57-70	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	22-26
15631880-6	2004	Plasma LPL (+29 +/- 11%; p=0.01) and hepatic lipase (+5 +/- 3%; p=0.01) activities increased in this group suggesting higher TG utilization and turnover.	Thioguanine	125-127	lipase C, hepatic type	Homo sapiens	37-51
15364160-7	2004	Serum apo C III levels were found to be positively associated with plasma TG ( r = 0.527, P &lt; 0.001), TC (r = 0.424, P &lt; 0.001), LDL-C (r = 0.308, P &lt; 0.01) concentrations, and carotid IMT (r =0.359, P &lt; 0.01 ).	Thioguanine	74-76	apolipoprotein C3	Homo sapiens	6-15
15682351-5	2004	Thus, the lipoprotein abnormality associated with PI use was increased LDL cholesterol, whereas changes in TG and HDL metabolism were associated with insulin resistance, independent of PI use.	Thioguanine	107-109	insulin	Homo sapiens	150-157
15279797-8	2004	To date, signalling cascades involving the Ataxia telangiectasia mutated (ATM), ATM- and Rad3-related (ATR), as well as the stress-activated kinases JNK/SAPK and p38alpha have been linked with methylating agent and 6-thioguanine (TG) treatments, while cisplatin damage was reported to activate the c-Abl and JNK/SAPK kinases in MMR-dependent manner.	Thioguanine	215-228	ATM serine/threonine kinase	Homo sapiens	43-72
15385838-1	2004	Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	130-143	thiopurine S-methyltransferase	Homo sapiens	0-30
15385838-1	2004	Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	130-143	thiopurine S-methyltransferase	Homo sapiens	32-36
15367709-0	2004	CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.	Thioguanine	70-83	checkpoint kinase 1	Homo sapiens	0-4
15367709-0	2004	CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.	Thioguanine	70-83	checkpoint kinase 2	Homo sapiens	9-13
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	29-33	checkpoint kinase 1	Homo sapiens	91-95
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	29-33	checkpoint kinase 1	Homo sapiens	107-111
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	29-33	checkpoint kinase 2	Homo sapiens	124-128
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	29-33	checkpoint kinase 2	Homo sapiens	139-143
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	29-33	checkpoint kinase 1	Homo sapiens	107-111
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	29-33	checkpoint kinase 2	Homo sapiens	139-143
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	264-268	checkpoint kinase 1	Homo sapiens	91-95
15367709-3	2004	We show that, in response to 6-TG (3 micromol/L x 24 hours), activating phosphorylation of CHK1 at Ser317 [CHK1(pS317)] and CHK2 at Thr68 [CHK2(pT68)] are induced differentially during a prolonged course (up to 6 days) of MMR-mediated cell cycle arrests following 6-TG treatment, with CHK1(pS317) being induced within 1 day and CHK2(pT68) being induced later.	Thioguanine	264-268	checkpoint kinase 2	Homo sapiens	124-128
15367709-4	2004	Using chemical inhibitors and small interfering RNA of the signaling kinases, we show that a MMR-mediated 6-TG-induced G2 arrest is ATR/CHK1 dependent but ATM/CHK2 independent and that ATR/CHK1 signaling is responsible for both initiation and maintenance of the G2 arrest.	Thioguanine	106-110	ATR serine/threonine kinase	Homo sapiens	132-135
15367709-4	2004	Using chemical inhibitors and small interfering RNA of the signaling kinases, we show that a MMR-mediated 6-TG-induced G2 arrest is ATR/CHK1 dependent but ATM/CHK2 independent and that ATR/CHK1 signaling is responsible for both initiation and maintenance of the G2 arrest.	Thioguanine	106-110	checkpoint kinase 1	Homo sapiens	136-140
15367709-4	2004	Using chemical inhibitors and small interfering RNA of the signaling kinases, we show that a MMR-mediated 6-TG-induced G2 arrest is ATR/CHK1 dependent but ATM/CHK2 independent and that ATR/CHK1 signaling is responsible for both initiation and maintenance of the G2 arrest.	Thioguanine	106-110	ATM serine/threonine kinase	Homo sapiens	155-158
15367709-4	2004	Using chemical inhibitors and small interfering RNA of the signaling kinases, we show that a MMR-mediated 6-TG-induced G2 arrest is ATR/CHK1 dependent but ATM/CHK2 independent and that ATR/CHK1 signaling is responsible for both initiation and maintenance of the G2 arrest.	Thioguanine	106-110	checkpoint kinase 2	Homo sapiens	159-163
15367709-4	2004	Using chemical inhibitors and small interfering RNA of the signaling kinases, we show that a MMR-mediated 6-TG-induced G2 arrest is ATR/CHK1 dependent but ATM/CHK2 independent and that ATR/CHK1 signaling is responsible for both initiation and maintenance of the G2 arrest.	Thioguanine	106-110	ATR serine/threonine kinase	Homo sapiens	185-188
15367709-4	2004	Using chemical inhibitors and small interfering RNA of the signaling kinases, we show that a MMR-mediated 6-TG-induced G2 arrest is ATR/CHK1 dependent but ATM/CHK2 independent and that ATR/CHK1 signaling is responsible for both initiation and maintenance of the G2 arrest.	Thioguanine	106-110	checkpoint kinase 1	Homo sapiens	189-193
15367709-5	2004	However, CHK2(pT68) seems to be involved in a subsequent tetraploid G1 arrest, which blocks cells that escape from the G2-M checkpoint following 6-TG treatment.	Thioguanine	145-149	checkpoint kinase 2	Homo sapiens	9-13
15367709-6	2004	Furthermore, we show that CHK2 is hyperphosphorylated at later times following 6-TG treatment and the phosphorylation of CHK2 seems to be ATM independent but up-regulated when ATR or CHK1 is reduced.	Thioguanine	79-83	checkpoint kinase 2	Homo sapiens	26-30
15367709-6	2004	Furthermore, we show that CHK2 is hyperphosphorylated at later times following 6-TG treatment and the phosphorylation of CHK2 seems to be ATM independent but up-regulated when ATR or CHK1 is reduced.	Thioguanine	79-83	ATR serine/threonine kinase	Homo sapiens	176-179
15367709-6	2004	Furthermore, we show that CHK2 is hyperphosphorylated at later times following 6-TG treatment and the phosphorylation of CHK2 seems to be ATM independent but up-regulated when ATR or CHK1 is reduced.	Thioguanine	79-83	checkpoint kinase 1	Homo sapiens	183-187
15367709-7	2004	Thus, our data suggest that CHK1(pS317) is involved in a MMR-mediated 6-TG-induced G2 arrest, whereas CHK2(pT68) seems to be involved in a subsequent tetraploid G1-S checkpoint.	Thioguanine	70-74	checkpoint kinase 1	Homo sapiens	28-32
15279797-8	2004	To date, signalling cascades involving the Ataxia telangiectasia mutated (ATM), ATM- and Rad3-related (ATR), as well as the stress-activated kinases JNK/SAPK and p38alpha have been linked with methylating agent and 6-thioguanine (TG) treatments, while cisplatin damage was reported to activate the c-Abl and JNK/SAPK kinases in MMR-dependent manner.	Thioguanine	230-232	ATM serine/threonine kinase	Homo sapiens	43-72
15320960-5	2004	Expression cloning of viral IFN-blocking genes into 2fTGH and consequent selection with IFN-alpha and 6-thioguanine result in the outgrowth of cells that are no longer responsive to IFN-alpha.	Thioguanine	102-115	interferon alpha 1	Homo sapiens	28-31
15320960-5	2004	Expression cloning of viral IFN-blocking genes into 2fTGH and consequent selection with IFN-alpha and 6-thioguanine result in the outgrowth of cells that are no longer responsive to IFN-alpha.	Thioguanine	102-115	interferon alpha 1	Homo sapiens	182-191
15298742-0	2004	Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and rapid non-extraction liquid chromatography.	Thioguanine	89-102	thiopurine S-methyltransferase	Homo sapiens	24-54
15167635-1	2004	Thiopurine S-methyltransferase (TPMT), which exhibits a genetic polymorphism, plays an important role in the metabolism of thiopurine drugs such as mercaptopurine, thioguanine, and azathioprine.	Thioguanine	164-175	thiopurine S-methyltransferase	Homo sapiens	0-30
15146465-4	2004	In cultured cells, loss of HPRT activity gives rise to 6-thioguanine (6-TG) resistance.	Thioguanine	55-68	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	27-31
15146465-4	2004	In cultured cells, loss of HPRT activity gives rise to 6-thioguanine (6-TG) resistance.	Thioguanine	70-74	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	27-31
15167635-1	2004	Thiopurine S-methyltransferase (TPMT), which exhibits a genetic polymorphism, plays an important role in the metabolism of thiopurine drugs such as mercaptopurine, thioguanine, and azathioprine.	Thioguanine	164-175	thiopurine S-methyltransferase	Homo sapiens	32-36
14715488-7	2004	In perinatal NB DA, PAF receptor antagonists BN-52021 and THG-315 reduced mPGES, COX-2, and PGE(2) levels and were associated with increased DA tone.	Thioguanine	58-61	PCNA clamp associated factor	Homo sapiens	20-23
15110787-0	2004	Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway.	Thioguanine	40-53	ATR serine/threonine kinase	Homo sapiens	67-70
15110787-0	2004	Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway.	Thioguanine	40-53	checkpoint kinase 1	Homo sapiens	71-75
15110787-3	2004	In this study, we found that prolonged (up to 4 days) treatment with 6-TG (3microM) resulted in a progressive phosphorylation of Chk1 and Chk2 in MMR(+) HeLa cells, correlating temporally with a drug-induced G2/M arrest.	Thioguanine	69-73	checkpoint kinase 1	Homo sapiens	129-133
15110787-3	2004	In this study, we found that prolonged (up to 4 days) treatment with 6-TG (3microM) resulted in a progressive phosphorylation of Chk1 and Chk2 in MMR(+) HeLa cells, correlating temporally with a drug-induced G2/M arrest.	Thioguanine	69-73	checkpoint kinase 2	Homo sapiens	138-142
15110787-4	2004	Transfection of HeLa cells with small interfering RNA (siRNA) against the ataxia telangiectasia-related (ATR) kinase or against the Chk1 kinase destroyed the G2/M checkpoint and enhanced the apoptosis following 6-TG treatment.	Thioguanine	211-215	checkpoint kinase 1	Homo sapiens	132-136
14715488-7	2004	In perinatal NB DA, PAF receptor antagonists BN-52021 and THG-315 reduced mPGES, COX-2, and PGE(2) levels and were associated with increased DA tone.	Thioguanine	58-61	prostaglandin E synthase	Mus musculus	74-79
14715488-7	2004	In perinatal NB DA, PAF receptor antagonists BN-52021 and THG-315 reduced mPGES, COX-2, and PGE(2) levels and were associated with increased DA tone.	Thioguanine	58-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15049943-1	2004	The lipoprotein lipase coding gene sequence was analysed on a 10-year-old girl with new-onset Type 1 diabetes mellitus (DM), ketoacidosis and severe hypertriglyceridaemia (TG &gt; 112.9 mmol/l), revealing that the patient was a compound heterozygote for two mutations, D9N in exon 2 and S447X in exon 9.	Thioguanine	172-174	lipoprotein lipase	Homo sapiens	4-22
14734554-8	2004	The profiles of the excision of the Tg isomers with HeLa and E. coli cell extracts closely resembled those of hNTH1 and Endo III, confirming their major contribution to the repair of Tg isomers in cells.	Thioguanine	36-38	nth like DNA glycosylase 1	Homo sapiens	110-115
14734554-8	2004	The profiles of the excision of the Tg isomers with HeLa and E. coli cell extracts closely resembled those of hNTH1 and Endo III, confirming their major contribution to the repair of Tg isomers in cells.	Thioguanine	183-185	nth like DNA glycosylase 1	Homo sapiens	110-115
14643890-10	2004	In addition, 100microM methotrexate, an ABCC4 substrate or 100microM 6-thioguanine (6-TG), a compound whose monophosphate metabolite is an ABCC4 substrate, reduced efflux by &gt;40%.	Thioguanine	69-82	ATP binding cassette subfamily C member 4	Homo sapiens	139-144
14762172-3	2004	We confirmed previous findings that dietary cholesterol increased mouse Cyp7a1 activity in Het mice but decreased human Cyp7a1 activity in Tg+KO mice.	Thioguanine	139-141	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	120-126
14617633-2	2004	GAPDH accumulates in the nucleus after cells are treated with genotoxic drugs, and it is present in a protein complex that binds DNA modified by thioguanine incorporation.	Thioguanine	145-156	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
15099020-5	2004	MPTP-treated Tg and wildtype mice produced alpha-synuclein aggregates in the PBS-, deoxycholate-, and SDS-soluble fractions.	Thioguanine	13-15	synuclein, alpha	Mus musculus	43-58
15099020-6	2004	Aggregates of alpha-synuclein, although with different molecular weights, were also observed in rotenone-treated Tg and wildtype mice.	Thioguanine	113-115	synuclein, alpha	Mus musculus	14-29
14988262-4	2004	SOD-1 activity and reduced glutathione levels were higher, whereas malondialdehyde content was lower, in the renal cortex of SOD-Tg-db/db compared with NTg-db/db mice, consistent with a renal antioxidant effect in the transgenic mice.	Thioguanine	129-131	superoxide dismutase 1, soluble	Mus musculus	0-5
14988262-4	2004	SOD-1 activity and reduced glutathione levels were higher, whereas malondialdehyde content was lower, in the renal cortex of SOD-Tg-db/db compared with NTg-db/db mice, consistent with a renal antioxidant effect in the transgenic mice.	Thioguanine	129-131	superoxide dismutase 1	Homo sapiens	0-3
14988262-5	2004	Inulin clearance (C(IN)) and urinary excretion of guanosine 3",5"-cyclic monophosphate (U(cGMP)) were increased in SOD-Tg-db/db mice compared with corresponding values in nondiabetic mice or NTg-db/db mice.	Thioguanine	119-121	superoxide dismutase 1	Homo sapiens	115-118
14988262-6	2004	C(IN) and U(cGMP) were suppressed by Nomega-nitro-L-arginine methyl ester in SOD-Tg-db/db but not in NTg-db/db mice, implying nitric oxide (NO) dependence of these increases and enhanced renal NO bioactivity in SOD-Tg-db/db.	Thioguanine	81-83	superoxide dismutase 1	Homo sapiens	77-80
14643890-10	2004	In addition, 100microM methotrexate, an ABCC4 substrate or 100microM 6-thioguanine (6-TG), a compound whose monophosphate metabolite is an ABCC4 substrate, reduced efflux by &gt;40%.	Thioguanine	84-88	ATP binding cassette subfamily C member 4	Homo sapiens	139-144
14576848-1	2003	The genetic polymorphism of thiopurine methyltransferase (TPMT) is one of the most developed examples of pharmacogenetics, spanning from molecular genetics to clinical diagnostics for individualizing thiopurine therapy (i.e. azathioprine, mercaptopurine, and thioguanine).	Thioguanine	259-270	thiopurine S-methyltransferase	Homo sapiens	28-56
15134140-4	2004	Livers from animals fed the t10, c12-CLA diet contained four times more lipids than those of the control group; this was mainly due to an increase in the TG fractions (fivefold), but cholesterol (threefold), cholesterol esters (threefold), and FFA (twofold) were also significantly increased.	Thioguanine	154-156	clasper	Mus musculus	37-40
14673522-11	2004	CONCLUSION/INTERPRETATION: We conclude that the enhanced insulin sensitivity observed after short-term exercise training was associated with a marked decrease in TG(m) content in patients with Type 2 diabetes.	Thioguanine	162-164	insulin	Homo sapiens	57-64
14563826-5	2004	By stepwise multiple regression, the best prediction of ppTG was: (fasting ASP + apolipoprotein B + insulin + TG; r=0.806) for men and (fasting ASP + total cholesterol; r=0.574) for women.	Thioguanine	58-60	apolipoprotein B	Homo sapiens	81-97
14563826-5	2004	By stepwise multiple regression, the best prediction of ppTG was: (fasting ASP + apolipoprotein B + insulin + TG; r=0.806) for men and (fasting ASP + total cholesterol; r=0.574) for women.	Thioguanine	58-60	insulin	Homo sapiens	100-107
14717981-5	2004	Fibrin formed during the lag phase of TG by a snake venom enzyme which only removed fibrinopeptide A induced an immediate burst of TG, that was inhibited by a monoclonal antibody against GPIb (6D1) that abolishes ristocetin-induced binding of VWF to platelets.	Thioguanine	38-40	von Willebrand factor	Homo sapiens	243-246
14996438-10	2004	Thus, the -790T/G MMP-2 genotype might be used as a genetic marker representing MMP-2 promoter variability for the TVD with odds ratio for TT and TG genotypes 2.59, 95% confidential interval 1.21-5.55, P=0.009.	Thioguanine	146-148	matrix metallopeptidase 2	Homo sapiens	18-23
14996438-10	2004	Thus, the -790T/G MMP-2 genotype might be used as a genetic marker representing MMP-2 promoter variability for the TVD with odds ratio for TT and TG genotypes 2.59, 95% confidential interval 1.21-5.55, P=0.009.	Thioguanine	146-148	matrix metallopeptidase 2	Homo sapiens	80-85
15136753-4	2003	Mutation induction at the HPRT locus was detected to measure 6-thioguanine-resistant clones.	Thioguanine	61-74	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	26-30
14705778-4	2003	Despite the involvement of guanylate kinase in 6-thioguanine, mercaptopurine, and abasic guanosine analog (e.g., ganciclovir) activation, studies have only recently focused on the molecular basis of the structure to function relationship of a mammalian guanylate kinase.	Thioguanine	47-60	guanylate kinase 1	Homo sapiens	27-43
14556746-1	2003	In humans, the enzyme thiopurine methyltransferase (TPMT) metabolizes 6-thiopurine (6-TP) medications, including 6-thioguanine, 6-mercaptopurine and azathioprine, commonly used for immune suppression and for the treatment of hematopoietic malignancies.	Thioguanine	113-126	thiopurine S-methyltransferase	Homo sapiens	22-50
14556746-1	2003	In humans, the enzyme thiopurine methyltransferase (TPMT) metabolizes 6-thiopurine (6-TP) medications, including 6-thioguanine, 6-mercaptopurine and azathioprine, commonly used for immune suppression and for the treatment of hematopoietic malignancies.	Thioguanine	113-126	thiopurine S-methyltransferase	Homo sapiens	52-56
14992447-0	2004	Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn"s disease on AZA therapy.	Thioguanine	38-51	interferon gamma	Homo sapiens	95-111
14992447-7	2004	Lymphocyte DNA 6-TG metabolite levels were correlated with INF-gamma and IL-10 cytokine profiles using the OptEIA kit (Pharmigen).	Thioguanine	15-19	interleukin 10	Homo sapiens	73-78
14992447-10	2004	This study suggests a preferential dampening of the TH1 response on exposure to 6-TG and a possible immunosuppressive mechanism of action for AZA.	Thioguanine	80-84	negative elongation factor complex member C/D	Homo sapiens	52-55
14981803-4	2004	PT was correlated with the levels of plasma BG and apo E (r = 0.500, P = 0.012), the levels of Fg was positively correlated with BG (r = 0.598, P = 0.000), and BPC of HTG subjects was negatively correlated with TG (r = -0.489, P &lt; 0.05).	Thioguanine	168-170	fibrinogen beta chain	Homo sapiens	95-97
14981803-7	2004	Plasma GMP-140 was not obviously correlated with plasma TG content, but was positively correlated with plasma TC and LDL-C contents.	Thioguanine	56-58	selectin P	Homo sapiens	7-14
14630365-0	2003	Determination of thiopurine S-methyltransferase activity in erythrocytes using 6-thioguanine as substrate and a non-extraction liquid chromatographic technique.	Thioguanine	79-92	thiopurine S-methyltransferase	Homo sapiens	17-47
14630365-9	2003	TPMT is increasingly used in clinical practice to ensure optimisation of treatment with thioguanine drugs.	Thioguanine	88-99	thiopurine S-methyltransferase	Homo sapiens	0-4
14683455-11	2003	In muscle and liver, adiponectin activated AMP kinase and PPARalpha pathways thereby increasing beta-oxidation of lipids, leading to decreased TG content, which ameliorated insulin resistance under a high-fat diet.	Thioguanine	143-145	adiponectin, C1Q and collagen domain containing	Mus musculus	21-32
14568129-3	2003	At 0 h of recovery from 2 h of hypoxia, both p-AKT and p-ERK signals were induced at a slightly lower level in Tg (1.1-1.2-fold) compared to those of Wt (1.2-1.5-fold) animals.	Thioguanine	111-113	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	55-60
14597765-6	2003	Intraperitoneal injection of N-2-mercaptopropionyl glycine, an antioxidant, normalized cardiac hypertrophy in Tg-DN-Trx1 mice.	Thioguanine	110-112	thioredoxin 1	Mus musculus	116-120
14576848-1	2003	The genetic polymorphism of thiopurine methyltransferase (TPMT) is one of the most developed examples of pharmacogenetics, spanning from molecular genetics to clinical diagnostics for individualizing thiopurine therapy (i.e. azathioprine, mercaptopurine, and thioguanine).	Thioguanine	259-270	thiopurine S-methyltransferase	Homo sapiens	58-62
14621189-7	2003	In addition, ventricular activation of extracellular signal-regulated kinase (ERK) induced by acute injection of Ang II was also diminished in BNP-Tg mice, as was activation of ERK kinase (MEK).	Thioguanine	147-149	mitogen-activated protein kinase 1	Mus musculus	39-76
14627750-1	2003	OBJECTIVE: A relationship between free fatty acids, intramuscular triglycerides (TG(M)s), and insulin resistance is widely accepted.	Thioguanine	81-83	insulin	Homo sapiens	94-101
13679074-5	2003	Using a recombinant yeast expression system, kinetic parameters (K(m) and V(max)) of 6-thioguanine S-methylation of the four TPMT variants were determined and compared to those obtained with wild-type TPMT.	Thioguanine	85-98	thiopurine S-methyltransferase	Homo sapiens	125-129
14676365-4	2003	Mutation induction in hprt locus was detected to measure 6-thioguanine resistant colonies.	Thioguanine	57-70	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	22-26
14621189-7	2003	In addition, ventricular activation of extracellular signal-regulated kinase (ERK) induced by acute injection of Ang II was also diminished in BNP-Tg mice, as was activation of ERK kinase (MEK).	Thioguanine	147-149	mitogen-activated protein kinase 1	Mus musculus	78-81
14621189-7	2003	In addition, ventricular activation of extracellular signal-regulated kinase (ERK) induced by acute injection of Ang II was also diminished in BNP-Tg mice, as was activation of ERK kinase (MEK).	Thioguanine	147-149	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	113-119
14621189-7	2003	In addition, ventricular activation of extracellular signal-regulated kinase (ERK) induced by acute injection of Ang II was also diminished in BNP-Tg mice, as was activation of ERK kinase (MEK).	Thioguanine	147-149	natriuretic peptide type B	Mus musculus	143-146
14621189-7	2003	In addition, ventricular activation of extracellular signal-regulated kinase (ERK) induced by acute injection of Ang II was also diminished in BNP-Tg mice, as was activation of ERK kinase (MEK).	Thioguanine	147-149	mitogen-activated protein kinase 1	Mus musculus	177-180
14501164-8	2003	In muscle, adiponectin activated AMP kinase and PPARgamma pathways, thereby increasing beta-oxidation of lipids, leading to decreased TG content, which ameliorated muscle insulin resistance.	Thioguanine	134-136	adiponectin, C1Q and collagen domain containing	Mus musculus	11-22
13130505-9	2003	The inhibition of TG-catalyzed reactions by cystamine (1 mM) blocked the activation pathway of caspase-3, with an evident reduction of enzyme cleavage.	Thioguanine	18-20	caspase 3	Homo sapiens	95-104
14511127-7	2003	Consistent with the changes of PKC activities, diabetic Tg showed decreased expression of PKC alpha in endoneurium, whereas there was an increased expression of PKC beta II in epineurium in both diabetic Tg and diabetic Lm.	Thioguanine	56-58	protein kinase C, alpha	Mus musculus	31-34
14511127-7	2003	Consistent with the changes of PKC activities, diabetic Tg showed decreased expression of PKC alpha in endoneurium, whereas there was an increased expression of PKC beta II in epineurium in both diabetic Tg and diabetic Lm.	Thioguanine	56-58	protein kinase C, alpha	Mus musculus	90-99
12940925-2	2003	AIMS: : To evaluate the tolerance and efficacy of TG in patients with Crohn"s disease, intolerant or resistant to AZA/MP.	Thioguanine	50-52	azurocidin 1	Homo sapiens	114-120
14584598-1	2003	Lipase-catalyzed interesterification was used to prepare structured TG from coconut oil TG by partially replacing some of the atherogenic saturated FA with stearic acid, which is known to have a neutral effect on lipid levels in the body.	Thioguanine	68-70	lipase G, endothelial type	Rattus norvegicus	0-6
12940925-12	2003	CONCLUSIONS: TG is a possible alternative treatment in Crohn"s disease patients, intolerant (especially for pancreatitis) or resistant to AZA/MP.	Thioguanine	13-15	azurocidin 1	Homo sapiens	138-144
12853977-6	2003	Acute expression of RET/PTC3 or RET/PTC3(Y541F), but not PTC2/PDZ, inhibited TSH-induced Tg and NIS expression, suggesting that activation of Shc-Ras, but not PLCgamma, is required for RET/PTC-induced dedifferentiation.	Thioguanine	89-91	ret proto-oncogene	Rattus norvegicus	20-23
12853977-6	2003	Acute expression of RET/PTC3 or RET/PTC3(Y541F), but not PTC2/PDZ, inhibited TSH-induced Tg and NIS expression, suggesting that activation of Shc-Ras, but not PLCgamma, is required for RET/PTC-induced dedifferentiation.	Thioguanine	89-91	ret proto-oncogene	Rattus norvegicus	32-35
12853977-6	2003	Acute expression of RET/PTC3 or RET/PTC3(Y541F), but not PTC2/PDZ, inhibited TSH-induced Tg and NIS expression, suggesting that activation of Shc-Ras, but not PLCgamma, is required for RET/PTC-induced dedifferentiation.	Thioguanine	89-91	ret proto-oncogene	Rattus norvegicus	32-35
12853977-7	2003	Accordingly, acute expression of H-Ras(V12) or of a constitutively active MEK1 also blocked TSH-induced expression of Tg and NIS.	Thioguanine	118-120	mitogen activated protein kinase kinase 1	Rattus norvegicus	74-78
12934668-6	2003	Two hours after the administration of TNF-alpha, a further rise in TG (43%, P &lt; 0.05) was noted in controls, but not EFAD animals.	Thioguanine	67-69	tumor necrosis factor	Rattus norvegicus	38-47
12945231-5	2003	At 20 weeks of age, TGR(mRen2)27 rats showed higher levels of mRNA LIF and IL-6 respectively by 52 and 55% compared to the control rats [LIF TG+/-: 3.17 +/- 0.21, TG-/-: 2.09 +/- 0.03; p &lt; 0.001; n = 5; and IL-6 TG+/-: 1.53 +/- 0.13; TG-/-: 0.99 +/- 0.17; p &lt; 0.05; n = 5].	Thioguanine	20-22	renin 2 tandem duplication of Ren1	Mus musculus	24-29
12945231-5	2003	At 20 weeks of age, TGR(mRen2)27 rats showed higher levels of mRNA LIF and IL-6 respectively by 52 and 55% compared to the control rats [LIF TG+/-: 3.17 +/- 0.21, TG-/-: 2.09 +/- 0.03; p &lt; 0.001; n = 5; and IL-6 TG+/-: 1.53 +/- 0.13; TG-/-: 0.99 +/- 0.17; p &lt; 0.05; n = 5].	Thioguanine	20-22	LIF, interleukin 6 family cytokine	Rattus norvegicus	67-70
12945231-5	2003	At 20 weeks of age, TGR(mRen2)27 rats showed higher levels of mRNA LIF and IL-6 respectively by 52 and 55% compared to the control rats [LIF TG+/-: 3.17 +/- 0.21, TG-/-: 2.09 +/- 0.03; p &lt; 0.001; n = 5; and IL-6 TG+/-: 1.53 +/- 0.13; TG-/-: 0.99 +/- 0.17; p &lt; 0.05; n = 5].	Thioguanine	20-22	interleukin 6	Rattus norvegicus	75-79
12945231-5	2003	At 20 weeks of age, TGR(mRen2)27 rats showed higher levels of mRNA LIF and IL-6 respectively by 52 and 55% compared to the control rats [LIF TG+/-: 3.17 +/- 0.21, TG-/-: 2.09 +/- 0.03; p &lt; 0.001; n = 5; and IL-6 TG+/-: 1.53 +/- 0.13; TG-/-: 0.99 +/- 0.17; p &lt; 0.05; n = 5].	Thioguanine	20-22	LIF, interleukin 6 family cytokine	Rattus norvegicus	137-140
12945231-5	2003	At 20 weeks of age, TGR(mRen2)27 rats showed higher levels of mRNA LIF and IL-6 respectively by 52 and 55% compared to the control rats [LIF TG+/-: 3.17 +/- 0.21, TG-/-: 2.09 +/- 0.03; p &lt; 0.001; n = 5; and IL-6 TG+/-: 1.53 +/- 0.13; TG-/-: 0.99 +/- 0.17; p &lt; 0.05; n = 5].	Thioguanine	20-22	interleukin 6	Rattus norvegicus	210-214
12945231-5	2003	At 20 weeks of age, TGR(mRen2)27 rats showed higher levels of mRNA LIF and IL-6 respectively by 52 and 55% compared to the control rats [LIF TG+/-: 3.17 +/- 0.21, TG-/-: 2.09 +/- 0.03; p &lt; 0.001; n = 5; and IL-6 TG+/-: 1.53 +/- 0.13; TG-/-: 0.99 +/- 0.17; p &lt; 0.05; n = 5].	Thioguanine	141-143	renin 2 tandem duplication of Ren1	Mus musculus	24-29
12945231-5	2003	At 20 weeks of age, TGR(mRen2)27 rats showed higher levels of mRNA LIF and IL-6 respectively by 52 and 55% compared to the control rats [LIF TG+/-: 3.17 +/- 0.21, TG-/-: 2.09 +/- 0.03; p &lt; 0.001; n = 5; and IL-6 TG+/-: 1.53 +/- 0.13; TG-/-: 0.99 +/- 0.17; p &lt; 0.05; n = 5].	Thioguanine	141-143	renin 2 tandem duplication of Ren1	Mus musculus	24-29
12949626-1	2003	Thiopurine methyltransferase (TPMT) catalyzes the inactivation of thiopurine drugs (mercaptopurine, thioguanine and azathioprine) used to treat acute lymphoblastic leukemia, autoimmune diseases and recipients of transplanted organs.	Thioguanine	100-111	thiopurine S-methyltransferase	Homo sapiens	0-28
12949626-1	2003	Thiopurine methyltransferase (TPMT) catalyzes the inactivation of thiopurine drugs (mercaptopurine, thioguanine and azathioprine) used to treat acute lymphoblastic leukemia, autoimmune diseases and recipients of transplanted organs.	Thioguanine	100-111	thiopurine S-methyltransferase	Homo sapiens	30-34
12910674-5	2003	PAI-1 and Fg levels were strongly correlated with serum TG, apoC II, C III and E levels (r = 0.400, 0.408, 0.497, 0.454, P &lt; 0.01 and r = 0.642, 0.581, 0.673, 0.304, P &lt; 0.01, respectively), and negatively correlated with HDL-C (r = -0.366, -0.524, P &lt; 0.01).	Thioguanine	56-58	serpin family E member 1	Homo sapiens	0-5
12665503-3	2003	Here we report that transgenic mice with cardiac specific iNOS-overexpression and concomitant myoglobin-deficiency (tg-iNOS+/myo-/-) develop signs of heart failure with cardiac hypertrophy, ventricular dilatation, and interstitial fibrosis.	Thioguanine	116-118	nitric oxide synthase 2, inducible	Mus musculus	119-123
12796402-7	2003	The ectopically expressed hMLH1 protein restored a MMR-proficient phenotype in the hMLH1(+) transfectants, showing a significantly increased and prolonged G(2)-M arrest followed by cell death after 6-TG exposure, compared with the vector controls.	Thioguanine	198-202	mutL homolog 1	Homo sapiens	26-31
12796402-10	2003	In contrast, single-strand breaks (SSBs) were more frequent and longer lived in MMR(+) cells, and the duration of SSB formation was temporally correlated with the time course of 6-TG-induced G(2)-M arrest.	Thioguanine	178-182	small RNA binding exonuclease protection factor La	Homo sapiens	35-38
12880105-4	2003	Dietary CLA increased TG, total cholesterol, and HDL cholesterol levels in plasma.	Thioguanine	22-24	selectin P ligand	Homo sapiens	8-11
12695342-7	2003	The ratios of MDZ C(max), AUC(0- infinity), t(1/2) and bioavailability between Tg-CYP3A4 and WT mice after the oral dose of MDZ were 0.3, 0.6, 0.5, and 0.5, respectively.	Thioguanine	79-81	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
12880105-5	2003	The increased plasma TG level could be caused by increased FA synthesis in the liver after CLA feeding, because the activity of FA synthase in the liver increased after dietary CLA treatment.	Thioguanine	21-23	selectin P ligand	Homo sapiens	91-94
12880105-5	2003	The increased plasma TG level could be caused by increased FA synthesis in the liver after CLA feeding, because the activity of FA synthase in the liver increased after dietary CLA treatment.	Thioguanine	21-23	selectin P ligand	Homo sapiens	177-180
12703179-9	2003	The insulin concentration in obese men correlated with BMI, TG, VLDL-C and HDL and, in women with BMI, TG and VLDL-C.	Thioguanine	60-62	insulin	Homo sapiens	4-11
12562870-3	2003	On LSD, the rise of the plasma concentrations of TG and nonesterified fatty acid (NEFA) was, respectively, 19% and 34% in LDLR KO mice, and 21% and 35% in apoE KO mice, and that of plasma cholesterol was limited to the LDLR KO group alone (15%).	Thioguanine	49-51	low density lipoprotein receptor	Mus musculus	122-126
12809172-11	2003	In conclusion, because TG binding to megalin is greatest at acidic pH, it is possible that TG does not dissociate from megalin in the lysosomal pathway.	Thioguanine	23-25	LDL receptor related protein 2	Rattus norvegicus	37-44
12616526-4	2003	Here we demonstrate that, by using sensitive immune-complex kinase assays in human brain-metastatic (70W) melanoma cells, TrkC receptors associate with a kinase activity exhibiting a dose-dependent susceptibility to inhibition by the purine-analogs 6-thioguanine and 2-aminopurine.	Thioguanine	249-262	neurotrophic receptor tyrosine kinase 3	Homo sapiens	122-126
12962322-2	2003	The nuclear magnetic resonance studies of Tg-HbP revealed that the conformation of the alpha1beta1 and alpha1beta1 interfaces of the protein in the deoxy state are indistinguishable from that of deoxy HbA, whereas the conformation of the microenvironment of His-103(alpha) of Tg-HbP, a residue of the alpha1beta1 interface, is distinct from that of HbA in the R-state.	Thioguanine	42-44	heme binding protein 1	Homo sapiens	45-48
12703179-9	2003	The insulin concentration in obese men correlated with BMI, TG, VLDL-C and HDL and, in women with BMI, TG and VLDL-C.	Thioguanine	103-105	insulin	Homo sapiens	4-11
12564931-3	2003	We therefore hypothesized that inhibition of TG accumulation in the ER lumen, secondary to MTP inhibition, is the primary mechanism whereby naringenin blocks lipidation and subsequent secretion of apoB.	Thioguanine	45-47	apolipoprotein B	Homo sapiens	197-201
12564931-11	2003	Taken together, our results indicate that naringenin inhibits the lipidation and subsequent secretion of apoB-containing lipoproteins primarily by limiting the accumulation of TG in the ER lumen, secondary to MTP inhibition.	Thioguanine	176-178	apolipoprotein B	Homo sapiens	105-109
12775233-6	2003	The MTP-493 T/T diabetic group had significantly higher TG (P &lt; 0.05), VLDL-CH (P &lt; 0.05) and smaller LDL particle size (P &lt; 0.001) than the MTP-493 common genotype group.	Thioguanine	56-58	microsomal triglyceride transfer protein	Homo sapiens	4-7
12636050-7	2003	BDC/l correlated significantly with age, total and LDL-C, apolipoprotein B and TG, while BDC/LDL-C negatively correlated with total cholesterol, apolipoprotein B, LDL/TG and LDL/HDL ratios.	Thioguanine	167-169	component of oligomeric golgi complex 2	Homo sapiens	93-98
12479869-5	2003	Therefore, we have studied the effect of HOCl on the function of HDL subclass 3 (HDL3) and triglyceride-enriched HDL3 (TG-HDL3) in PLTP-mediated processes in vitro.	Thioguanine	119-121	phospholipid transfer protein	Homo sapiens	131-135
12492734-2	2003	Measurement of the AZA/MP metabolites, thioguanine (TG) and methylmercaptopurine (MMP), has been suggested as a means to optimize therapy with AZA/MP in inflammatory bowel disease.	Thioguanine	39-50	azurocidin 1	Homo sapiens	19-25
12492734-2	2003	Measurement of the AZA/MP metabolites, thioguanine (TG) and methylmercaptopurine (MMP), has been suggested as a means to optimize therapy with AZA/MP in inflammatory bowel disease.	Thioguanine	39-50	azurocidin 1	Homo sapiens	143-149
12492734-2	2003	Measurement of the AZA/MP metabolites, thioguanine (TG) and methylmercaptopurine (MMP), has been suggested as a means to optimize therapy with AZA/MP in inflammatory bowel disease.	Thioguanine	52-54	azurocidin 1	Homo sapiens	19-25
12492734-2	2003	Measurement of the AZA/MP metabolites, thioguanine (TG) and methylmercaptopurine (MMP), has been suggested as a means to optimize therapy with AZA/MP in inflammatory bowel disease.	Thioguanine	52-54	azurocidin 1	Homo sapiens	143-149
12479869-5	2003	Therefore, we have studied the effect of HOCl on the function of HDL subclass 3 (HDL3) and triglyceride-enriched HDL3 (TG-HDL3) in PLTP-mediated processes in vitro.	Thioguanine	119-121	HDL3	Homo sapiens	113-117
12479869-5	2003	Therefore, we have studied the effect of HOCl on the function of HDL subclass 3 (HDL3) and triglyceride-enriched HDL3 (TG-HDL3) in PLTP-mediated processes in vitro.	Thioguanine	119-121	HDL3	Homo sapiens	113-117
12435799-6	2002	During incubation with TG, the monophosphorylated form of thioguanosine was transported by both MRP4 and MRP5; the highest transport rate was for MRP4.	Thioguanine	23-25	ATP binding cassette subfamily C member 4	Homo sapiens	96-100
12717780-4	2003	After recovery of lambdaEG10 phage, point mutations in the gpt gene and deletions in the red/gam genes are identified by 6-thioguanine and Spi(-) selection, respectively.	Thioguanine	121-134	glutamic--pyruvic transaminase	Rattus norvegicus	59-62
14529546-2	2003	Both mercaptopurine and thioguanine are substrates for hypoxanthine-guanine phosphoribosyltransferase and are converted into the ribonucleotides 6-thioguanosine monophosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) respectively.	Thioguanine	24-35	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	55-101
12511546-3	2003	Laser Doppler imaging revealed a markedly increased recovery of blood perfusion in ischemic limbs of eNOS-Tg mice (44% increase) compared with that in wild-type mice.	Thioguanine	106-108	nitric oxide synthase 3, endothelial cell	Mus musculus	101-105
12511546-4	2003	Angiography showed a marked increase in basal and ischemia-induced collateral vessel formation in eNOS-Tg mice.	Thioguanine	103-105	nitric oxide synthase 3, endothelial cell	Mus musculus	98-102
12511546-5	2003	Basal capillary densities and tissue cGMP levels were increased in eNOS-Tg mice (1.8-fold and 1.6-fold versus wild-type mice, respectively).	Thioguanine	72-74	nitric oxide synthase 3, endothelial cell	Mus musculus	67-71
12511546-6	2003	Ischemia-induced neocapillary formation and cGMP accumulation were markedly increased in eNOS-Tg mice (3.6-fold and 4.1-fold versus preischemia levels, respectively), whereas those in wild-type mice were much less (1.8-fold and 1.5-fold, respectively).	Thioguanine	94-96	nitric oxide synthase 3, endothelial cell	Mus musculus	89-93
12511546-9	2003	Aortic basal eNOS expression was increased 3.3-fold, and VEGF-mediated eNOS phosphorylation was markedly induced in aortas of eNOS-Tg compared with preischemia levels (4.2-fold), whereas much smaller changes were observed in wild-type mice (1.8-fold increase).	Thioguanine	131-133	vascular endothelial growth factor A	Mus musculus	57-61
12511546-9	2003	Aortic basal eNOS expression was increased 3.3-fold, and VEGF-mediated eNOS phosphorylation was markedly induced in aortas of eNOS-Tg compared with preischemia levels (4.2-fold), whereas much smaller changes were observed in wild-type mice (1.8-fold increase).	Thioguanine	131-133	nitric oxide synthase 3, endothelial cell	Mus musculus	71-75
12511546-9	2003	Aortic basal eNOS expression was increased 3.3-fold, and VEGF-mediated eNOS phosphorylation was markedly induced in aortas of eNOS-Tg compared with preischemia levels (4.2-fold), whereas much smaller changes were observed in wild-type mice (1.8-fold increase).	Thioguanine	131-133	nitric oxide synthase 3, endothelial cell	Mus musculus	71-75
12435799-6	2002	During incubation with TG, the monophosphorylated form of thioguanosine was transported by both MRP4 and MRP5; the highest transport rate was for MRP4.	Thioguanine	23-25	ATP binding cassette subfamily C member 5	Homo sapiens	105-109
12435799-6	2002	During incubation with TG, the monophosphorylated form of thioguanosine was transported by both MRP4 and MRP5; the highest transport rate was for MRP4.	Thioguanine	23-25	ATP binding cassette subfamily C member 4	Homo sapiens	146-150
12391284-0	2002	Identification of transdominant-negative genetic suppressor elements derived from hMSH2 that mediate resistance to 6-thioguanine.	Thioguanine	115-128	mutS homolog 2	Homo sapiens	82-87
12433494-3	2002	The ring has the usual 4C(1) shape and O-6 is in the tg position as frequently observed for sugars having the axial galacto configuration at C-4.	Thioguanine	53-55	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	39-42
12208477-1	2002	The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease.	Thioguanine	52-54	lipoprotein lipase	Homo sapiens	39-42
12372549-6	2002	RyR1 was decreased in the flocculus of the cerebellum in both the tg/tg-N and tg/tg-P groups compared to wild type (p = 0.0174, ANOVA).	Thioguanine	66-68	ryanodine receptor 1, skeletal muscle	Mus musculus	0-4
12372549-6	2002	RyR1 was decreased in the flocculus of the cerebellum in both the tg/tg-N and tg/tg-P groups compared to wild type (p = 0.0174, ANOVA).	Thioguanine	69-71	ryanodine receptor 1, skeletal muscle	Mus musculus	0-4
12372549-6	2002	RyR1 was decreased in the flocculus of the cerebellum in both the tg/tg-N and tg/tg-P groups compared to wild type (p = 0.0174, ANOVA).	Thioguanine	69-71	ryanodine receptor 1, skeletal muscle	Mus musculus	0-4
12600028-10	2002	It suggested that the variation of Apolipoprotein C III-Sac I locus was correlated with the TG level in children.	Thioguanine	92-94	apolipoprotein C3	Homo sapiens	35-55
12234183-3	2002	When the ATPase is incubated with Fe(2+) in the presence of H(2)O(2) and/or ascorbate, specific patterns of Fe(2+)-catalyzed oxidation and cleavage are observed in the SR ATPase, depending on its Ca(2+)-bound (E1-Ca(2)) or Ca(2+)-free conformation (E2-TG), as well as on the presence of ATP.	Thioguanine	252-254	dynein axonemal heavy chain 8	Homo sapiens	9-15
12234183-3	2002	When the ATPase is incubated with Fe(2+) in the presence of H(2)O(2) and/or ascorbate, specific patterns of Fe(2+)-catalyzed oxidation and cleavage are observed in the SR ATPase, depending on its Ca(2+)-bound (E1-Ca(2)) or Ca(2+)-free conformation (E2-TG), as well as on the presence of ATP.	Thioguanine	252-254	dynein axonemal heavy chain 8	Homo sapiens	171-177
12097330-7	2002	We conclude that, in addition to raising high density lipoprotein cholesterol concentrations, pharmacological LXR activation in mice leads to development of hepatic steatosis and secretion of atherogenic, large TG-rich VLDL particles.	Thioguanine	211-213	nuclear receptor subfamily 1, group H, member 3	Mus musculus	110-113
12135816-1	2002	BACKGROUND: Thiopurine S-methyltransferase (TPMT), which exhibits autosomal codominant polymorphism, plays an important role in the metabolism of thiopurine drugs such as mercaptopurine, thioguanine and azathioprine.	Thioguanine	187-198	thiopurine S-methyltransferase	Homo sapiens	12-42
12135816-1	2002	BACKGROUND: Thiopurine S-methyltransferase (TPMT), which exhibits autosomal codominant polymorphism, plays an important role in the metabolism of thiopurine drugs such as mercaptopurine, thioguanine and azathioprine.	Thioguanine	187-198	thiopurine S-methyltransferase	Homo sapiens	44-48
12235169-6	2002	The results indicate that exogenously supplied FAs, and their subsequently produced acyl-CoAs, are preferentially channeled by an FATP1 linked mechanism into the TG biosynthetic pathway and that such internalized lipids down-regulate de novo SM and cholesterol metabolism in actively growing 293 cells.	Thioguanine	162-164	solute carrier family 27 member 1	Homo sapiens	130-135
12458623-7	2002	Inhibition of MTP attenuated the turnover of newly synthesized Golgi membrane TG by approximately 50% and the turnover of microsomal membrane TG by approximately 40%.	Thioguanine	78-80	microsomal triglyceride transfer protein	Mus musculus	14-17
12458623-7	2002	Inhibition of MTP attenuated the turnover of newly synthesized Golgi membrane TG by approximately 50% and the turnover of microsomal membrane TG by approximately 40%.	Thioguanine	142-144	microsomal triglyceride transfer protein	Mus musculus	14-17
12489570-5	2002	RESULTS: (1) ADA activity in leukocytes, obtained from patients with Hashimoto"s disease, was significantly higher than in control leukocytes, as well as in leukocytes from patients with Graves" disease; (2) dCK activities in leukocytes from patients with both Graves" and Hashimoto"s diseases were approximately four and five times higher, respectively, than in leukocytes of control subjects; (3) a positive correlation was observed between dCK activity in leukocytes and serum Tg Ab concentration in patients with Graves" disease.	Thioguanine	480-482	adenosine deaminase	Homo sapiens	13-16
12489570-5	2002	RESULTS: (1) ADA activity in leukocytes, obtained from patients with Hashimoto"s disease, was significantly higher than in control leukocytes, as well as in leukocytes from patients with Graves" disease; (2) dCK activities in leukocytes from patients with both Graves" and Hashimoto"s diseases were approximately four and five times higher, respectively, than in leukocytes of control subjects; (3) a positive correlation was observed between dCK activity in leukocytes and serum Tg Ab concentration in patients with Graves" disease.	Thioguanine	480-482	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	208-211
12428919-3	2002	Exponentially growing SV40-transformed human fibroblasts were exposed to graded doses of mammography (29 kVp, tungsten anode, 50 microm Rh filter) or conventional X-rays and the frequency of 6-thioguanine-resistent HPRT-deficient mutants was determined.	Thioguanine	191-204	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	215-219
12145690-4	2002	6-TG inhibited endothelial cell proliferation triggered by fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) and delayed the repair of a mechanically wounded endothelial cell monolayer.	Thioguanine	0-4	fibroblast growth factor 2	Homo sapiens	59-85
12145690-4	2002	6-TG inhibited endothelial cell proliferation triggered by fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) and delayed the repair of a mechanically wounded endothelial cell monolayer.	Thioguanine	0-4	fibroblast growth factor 2	Homo sapiens	87-91
12145690-4	2002	6-TG inhibited endothelial cell proliferation triggered by fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) and delayed the repair of a mechanically wounded endothelial cell monolayer.	Thioguanine	0-4	vascular endothelial growth factor A	Homo sapiens	97-131
12145690-4	2002	6-TG inhibited endothelial cell proliferation triggered by fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) and delayed the repair of a mechanically wounded endothelial cell monolayer.	Thioguanine	0-4	vascular endothelial growth factor A	Homo sapiens	133-137
12145690-7	2002	In vivo, 6-TG inhibited basal, VEGF-induced, and FGF2-induced vascularization in the chick embryo chorioallantoic membrane and prevented neovascularization triggered by leukemia LIK cells or their conditioned medium.	Thioguanine	9-13	vascular endothelial growth factor A	Gallus gallus	31-35
12145690-7	2002	In vivo, 6-TG inhibited basal, VEGF-induced, and FGF2-induced vascularization in the chick embryo chorioallantoic membrane and prevented neovascularization triggered by leukemia LIK cells or their conditioned medium.	Thioguanine	9-13	fibroblast growth factor 2	Gallus gallus	49-53
12514935-8	2002	Compared to LPL 447S homozygous women carriers of the LPL 447X allele had significantly lower levels of very-low-density lipoprotein-triglyceride (VLDL-TG) (21.0%, p = 0.02).	Thioguanine	152-154	lipoprotein lipase	Homo sapiens	54-57
12170470-5	2002	(2)Stepwise regression analysis revealed that the independent variables to UCP3 gene -55 C--&gt;T were: HDL-C(P= 0.013)and LDL-C(P=0.012) in male NGT subgroup FA(P=0.023) in female NGT subgroup TG(P=0.004)in male DM subgroup, and waist to hip ratio (WHR)(P=0)in female DM subg roup.	Thioguanine	194-196	uncoupling protein 3	Homo sapiens	75-79
12600028-10	2002	It suggested that the variation of Apolipoprotein C III-Sac I locus was correlated with the TG level in children.	Thioguanine	92-94	adenylate cyclase 10	Homo sapiens	56-61
12065760-6	2002	In contrast, induction of TPMT produced a 1.6-fold decrease in sensitivity to 6-TG, a decrease in levels of DNA-TGN, and an increase in levels of methylated thioguanosine monophosphate.	Thioguanine	78-82	thiopurine S-methyltransferase	Homo sapiens	26-30
12094019-5	2002	Peripheral CD4(+) and CD8(+) T cell populations were significantly lower in tg than in Ntg, df, or Ndf mice.	Thioguanine	76-78	CD4 antigen	Mus musculus	11-14
12029550-5	2002	The thyroglobulin level was measured both during TSH-suppressive L-thyroxine therapy (Tg-on) and 4-6 weeks after L-thyroxine withdrawal (Tg-off, TSH&gt;20 mU/l).	Thioguanine	86-88	thyroglobulin	Homo sapiens	4-17
12045239-2	2002	We have made a T cell receptor (TCR) transgenic mouse specific for a tumor antigen and crossed TCR-TG mice to transgenic mice expressing the tumor antigen in hepatocytes (gag-TG).	Thioguanine	99-101	T cell receptor alpha variable 6-3	Mus musculus	95-98
12029550-5	2002	The thyroglobulin level was measured both during TSH-suppressive L-thyroxine therapy (Tg-on) and 4-6 weeks after L-thyroxine withdrawal (Tg-off, TSH&gt;20 mU/l).	Thioguanine	137-139	thyroglobulin	Homo sapiens	4-17
12109624-2	2002	In this study, we examined the effect of such surgery on serum TG and the course of the disease in 21 patients with PTC (mean age 38.5 yr), who after the initial surgery and radioactive iodine (RAI) ablation developed high TG (&gt;10 ng/ml) and negative 123I whole body scan (DxWBS).	Thioguanine	223-225	coiled-coil domain containing 6	Homo sapiens	116-119
12030002-4	2002	In animal models, MTP inhibitors have dramatic effects not only on plasma cholesterol and LDL levels but on TG levels as well, offering the potential for greater efficacy and plasma lipid control in both hypertriglyceridemia and mixed hyperlipidemia.	Thioguanine	108-110	metallothionein 1B	Homo sapiens	18-21
14694633-3	2002	Mutation in the hprt gene was screened by culture in the presence of the toxic purine analog, 6-thioguanine (6-TG).	Thioguanine	94-107	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	16-20
14694633-3	2002	Mutation in the hprt gene was screened by culture in the presence of the toxic purine analog, 6-thioguanine (6-TG).	Thioguanine	109-113	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	16-20
12007578-5	2002	In wild-type mice, production of VLDL-TG, and cholesterol were reduced by more than 50% by HOE 402 (P&lt;0.05), whereas VLDL apolipoprotein B (ApoB) secretion was unaffected, indicating that HOE 402 treatment changes the size, rather than the number of the secreted VLDL particles.	Thioguanine	38-40	CD320 antigen	Mus musculus	33-37
11827715-4	2002	The mutagenicity of APC was investigated at the HPRT locus, and the frequency of HPRT mutants was estimated by selection in medium containing 6-thioguanine (6-TG).	Thioguanine	142-155	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	81-85
11943718-8	2002	Leukocyte extravasation into tissue and up-regulated expression of adhesion molecules in the reperfused vessels were significantly inhibited in eNOS-Tg.	Thioguanine	149-151	nitric oxide synthase 3, endothelial cell	Mus musculus	144-148
11907145-2	2002	THP-1 macrophages were incubated with acetylated LDL, and the accumulated TG was depleted by incubation with the acyl-CoA synthetase inhibitor triacsin D in the presence of albumin.	Thioguanine	74-76	GLI family zinc finger 2	Homo sapiens	0-5
11827715-4	2002	The mutagenicity of APC was investigated at the HPRT locus, and the frequency of HPRT mutants was estimated by selection in medium containing 6-thioguanine (6-TG).	Thioguanine	157-161	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	81-85
11834142-2	2002	We hypothesized that changes in insulin sensitivity are an important determinant of exercise-induced changes in postprandial TG concentrations.	Thioguanine	125-127	insulin	Homo sapiens	32-39
11802779-7	2002	ABCC4 also mediates resistance to purine analogues 9-(2-phosphonylmethoxyethyl)-adenine and 6-thioguanine.	Thioguanine	92-105	ATP binding cassette subfamily C member 4	Homo sapiens	0-5
11756148-3	2002	This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis.	Thioguanine	176-189	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	72-119
11841564-1	2002	Recent studies indicate that the Tg2576 transgenic mouse model of Alzheimer"s disease [tg(hAPP)] demonstrates disturbances in plasma glucose and neuroendocrine function reminiscent of Alzheimer"s disease (AD).	Thioguanine	87-89	amyloid beta precursor protein	Homo sapiens	90-94
11841564-6	2002	In contrast to the liver, a significant depression in renal CYP2E1- and CYP4A-associated activities were demonstrated in tg(hAPP) mice.	Thioguanine	121-123	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	60-66
11841564-6	2002	In contrast to the liver, a significant depression in renal CYP2E1- and CYP4A-associated activities were demonstrated in tg(hAPP) mice.	Thioguanine	121-123	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	72-77
11841564-6	2002	In contrast to the liver, a significant depression in renal CYP2E1- and CYP4A-associated activities were demonstrated in tg(hAPP) mice.	Thioguanine	121-123	amyloid beta precursor protein	Homo sapiens	124-128
11841564-7	2002	The presence of the mutant hAPP protein was detected in the brain, kidney and livers of tg(hAPP) mice.	Thioguanine	88-90	amyloid beta precursor protein	Homo sapiens	27-31
11841564-7	2002	The presence of the mutant hAPP protein was detected in the brain, kidney and livers of tg(hAPP) mice.	Thioguanine	88-90	amyloid beta precursor protein	Homo sapiens	91-95
11756148-3	2002	This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis.	Thioguanine	176-189	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	121-125
11756148-3	2002	This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis.	Thioguanine	191-195	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	72-119
11756148-3	2002	This study sought to test this hypothesis by examining the frequency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene mutations, identified by both resistance to 6-thioguanine (6-TG) and gene analysis.	Thioguanine	191-195	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	121-125
11756148-9	2002	Unlike PNH cells, 6-TG-resistant cells expressed CD59, indicating that the HPRT mutations did not occur in PNH clones.	Thioguanine	18-22	CD59 molecule (CD59 blood group)	Homo sapiens	49-53
11756148-9	2002	Unlike PNH cells, 6-TG-resistant cells expressed CD59, indicating that the HPRT mutations did not occur in PNH clones.	Thioguanine	18-22	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	75-79
11751616-3	2002	Within the thyroid glands, 12 of 26 (46%) Tg-immunized pregnant mice were SRY positive (range, 1-1700 cells), whereas, in contrast, few SRY transcripts were detected in control thyroids from nonimmunized pregnant mice (P &lt; 0.05).	Thioguanine	42-44	sex determining region of Chr Y	Mus musculus	74-77
11751616-4	2002	At 5 wk postpartum, although SRY was still detected in the thyroids of 12 of 40 (30%) Tg-immunized mice, the number of male cells was markedly decreased (range, 1-30), and by 10 wk postpartum SRY had disappeared.	Thioguanine	86-88	sex determining region of Chr Y	Mus musculus	29-32
12210495-4	2002	Cells were isolated on gestation day 17 for determination of cloning efficiency and for selection of 6-thioguanine (6-TG)-resistant HGPRT mutants.	Thioguanine	101-114	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	132-137
11851866-7	2002	S-Il-1ra levels correlated with s-tg levels (r=0.38; P=0.047).	Thioguanine	34-36	interleukin 1 receptor antagonist	Homo sapiens	2-8
11851866-6	2002	Patients with Il-1ra in plaques showed higher [2.04 (1.70-3.14) mmol x L(-1) vs. 1.69 (1.09-1.99) mmol x L(-1); P &lt; 0.05] serum(s-)triglyceride(tg) levels, and a higher frequency of IgA seropositivity for C. pneumoniae (76% vs. 52%; P &lt; 0.05) than those without.	Thioguanine	147-149	interleukin 1 receptor antagonist	Homo sapiens	14-20
12210495-4	2002	Cells were isolated on gestation day 17 for determination of cloning efficiency and for selection of 6-thioguanine (6-TG)-resistant HGPRT mutants.	Thioguanine	116-120	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	132-137
11734575-7	2001	Among the whole population studied, as among the control and obese subgroups, fasting plasma apoA-IV correlated significantly with AUC of plasma TG (r = 0.60, P &lt; 0.001), AUC of chymomicron TG (r = 0.45, P &lt; 0.01), and AUC of nonchylomicron TG (r = 0.62, P &lt; 0.001).	Thioguanine	145-147	apolipoprotein A4	Homo sapiens	93-100
11729234-7	2001	Up-regulation of transforming growth factor-beta (TGF-beta) and monocyte chemoattractant protein-1 (MCP-1), as well as increased phosphorylation of extracellular signal-regulated kinase (ERK), were also significantly inhibited in the kidney of BNP-Tg.	Thioguanine	248-250	chemokine (C-C motif) ligand 2	Mus musculus	100-105
11729234-7	2001	Up-regulation of transforming growth factor-beta (TGF-beta) and monocyte chemoattractant protein-1 (MCP-1), as well as increased phosphorylation of extracellular signal-regulated kinase (ERK), were also significantly inhibited in the kidney of BNP-Tg.	Thioguanine	248-250	mitogen-activated protein kinase 1	Mus musculus	148-185
11729234-7	2001	Up-regulation of transforming growth factor-beta (TGF-beta) and monocyte chemoattractant protein-1 (MCP-1), as well as increased phosphorylation of extracellular signal-regulated kinase (ERK), were also significantly inhibited in the kidney of BNP-Tg.	Thioguanine	248-250	mitogen-activated protein kinase 1	Mus musculus	187-190
11735094-6	2001	RLP-C and RLP-C/plasma-triglyceride (TG) ratio in CAD with DM were higher than CAD without DM (P &lt;.01, P &lt;.05), and non-CAD with DM (P &lt;.001, P &lt;.05).	Thioguanine	37-39	aconitate decarboxylase 1	Homo sapiens	50-53
11735094-8	2001	After excluding the hypertriglyceridemic patients (&gt;200mg/dL), RLP-C/plasma-TG ratio was significantly higher in CAD with DM than CAD without DM (P &lt;.001) and non-CAD with DM (P &lt;.05).	Thioguanine	79-81	aconitate decarboxylase 1	Homo sapiens	116-119
11734575-7	2001	Among the whole population studied, as among the control and obese subgroups, fasting plasma apoA-IV correlated significantly with AUC of plasma TG (r = 0.60, P &lt; 0.001), AUC of chymomicron TG (r = 0.45, P &lt; 0.01), and AUC of nonchylomicron TG (r = 0.62, P &lt; 0.001).	Thioguanine	193-195	apolipoprotein A4	Homo sapiens	93-100
11734575-7	2001	Among the whole population studied, as among the control and obese subgroups, fasting plasma apoA-IV correlated significantly with AUC of plasma TG (r = 0.60, P &lt; 0.001), AUC of chymomicron TG (r = 0.45, P &lt; 0.01), and AUC of nonchylomicron TG (r = 0.62, P &lt; 0.001).	Thioguanine	193-195	apolipoprotein A4	Homo sapiens	93-100
11734575-9	2001	In conclusion, we show a strong link between fasting apoA-IV and postprandial TG metabolism.	Thioguanine	78-80	apolipoprotein A4	Homo sapiens	53-60
11679438-2	2001	The aim of the present study was to determine whether there is a causal relation between intramuscular TG accumulation and insulin sensitivity.	Thioguanine	103-105	insulin	Homo sapiens	123-130
11849617-2	2001	Most clinical laboratories estimate the concentration of LDL-C by the recommended routine method, the equation of Friedewald, in specimens from fasting subjects and with TG concentrations &lt; 4.52 mmol/L.	Thioguanine	170-172	component of oligomeric golgi complex 2	Homo sapiens	57-62
11698345-5	2001	Pre-existing in vivo HPRT mutants were removed from PHA-stimulated T lymphocytes before in vitro treatment with 2.4 mM AA for 24 h. Following cell growth to allow mutation expression, independent 6-thioguanine-resistant mutants were selected from large numbers of subcultures showing a 3-fold induction of mutant frequency on average.	Thioguanine	196-209	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	21-25
11679438-8	2001	In conclusion, overexpression of human LPL in muscle increases intramuscular TG accumulation, but does not affect whole-body or muscle-specific insulin-mediated uptake, findings that argue against a simple causal relation between intramuscular TG content and insulin resistance.	Thioguanine	77-79	lipoprotein lipase	Homo sapiens	39-42
11712415-2	2001	Moderate reduction of PPAR gamma activity by PPAR gamma/RXR inhibitors decreases TG content of WAT/muscle/liver due to increased leptin and increase in fatty-acid combustion and decrease in lipogenesis, thereby ameliorating HF diet-induced obesity and insulin resistance.	Thioguanine	81-83	peroxisome proliferator activated receptor gamma	Homo sapiens	22-32
11712415-2	2001	Moderate reduction of PPAR gamma activity by PPAR gamma/RXR inhibitors decreases TG content of WAT/muscle/liver due to increased leptin and increase in fatty-acid combustion and decrease in lipogenesis, thereby ameliorating HF diet-induced obesity and insulin resistance.	Thioguanine	81-83	peroxisome proliferator activated receptor gamma	Homo sapiens	45-55
11712415-1	2001	Potent activation of PPAR gamma by thiazolidinediones(TZD) increases TG content of WAT, thereby decreasing TG content of liver/muscle, leading to amelioration of insulin resistance at the expense of obesity.	Thioguanine	69-71	peroxisome proliferator activated receptor gamma	Homo sapiens	21-31
11712415-1	2001	Potent activation of PPAR gamma by thiazolidinediones(TZD) increases TG content of WAT, thereby decreasing TG content of liver/muscle, leading to amelioration of insulin resistance at the expense of obesity.	Thioguanine	107-109	peroxisome proliferator activated receptor gamma	Homo sapiens	21-31
11712415-2	2001	Moderate reduction of PPAR gamma activity by PPAR gamma/RXR inhibitors decreases TG content of WAT/muscle/liver due to increased leptin and increase in fatty-acid combustion and decrease in lipogenesis, thereby ameliorating HF diet-induced obesity and insulin resistance.	Thioguanine	81-83	retinoid X receptor alpha	Homo sapiens	56-59
11712415-4	2001	We conclude that although by different mechanisms, both PPAR gamma/RXR inhibitors and PPAR gamma agonist improve insulin resistance, which is associated with decreased TG content of muscle/liver and prevention of adipocyte hypertrophy.	Thioguanine	168-170	peroxisome proliferator activated receptor gamma	Homo sapiens	56-66
11712415-4	2001	We conclude that although by different mechanisms, both PPAR gamma/RXR inhibitors and PPAR gamma agonist improve insulin resistance, which is associated with decreased TG content of muscle/liver and prevention of adipocyte hypertrophy.	Thioguanine	168-170	retinoid X receptor alpha	Homo sapiens	67-70
11712415-4	2001	We conclude that although by different mechanisms, both PPAR gamma/RXR inhibitors and PPAR gamma agonist improve insulin resistance, which is associated with decreased TG content of muscle/liver and prevention of adipocyte hypertrophy.	Thioguanine	168-170	peroxisome proliferator activated receptor gamma	Homo sapiens	86-96
11712415-4	2001	We conclude that although by different mechanisms, both PPAR gamma/RXR inhibitors and PPAR gamma agonist improve insulin resistance, which is associated with decreased TG content of muscle/liver and prevention of adipocyte hypertrophy.	Thioguanine	168-170	insulin	Homo sapiens	113-120
11742110-2	2001	Because of its essential intracellular role, guanylate kinase is a target for a number of cancer chemotherapeutic agents such as 6-thioguanine and 8-azaguanine and is involved in antiviral drug activation.	Thioguanine	129-142	guanylate kinase 1	Mus musculus	45-61
11706194-4	2001	It is interesting that this increase in the total glutathione (TG) level was accompanied by a rise in glutathione reductase (GR; EC 1.6.4.2) activity.	Thioguanine	63-65	glutathione reductase 1	Zea mays	102-123
11706194-4	2001	It is interesting that this increase in the total glutathione (TG) level was accompanied by a rise in glutathione reductase (GR; EC 1.6.4.2) activity.	Thioguanine	63-65	glutathione reductase 1	Zea mays	125-127
11514234-5	2001	Incubation with OA, t10,c12-CLA, c9,t11-CLA and LA resulted in 6-, 4-, 2- and 1.8-fold increases in intracellular [(3)H]triglyceride ([(3)H]TG) compared with incubation with BSA alone.	Thioguanine	140-142	complement C9	Homo sapiens	33-43
11590213-1	2001	Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of TG.	Thioguanine	172-174	apolipoprotein C-III	Mus musculus	107-115
11590213-1	2001	Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of TG.	Thioguanine	172-174	apolipoprotein E	Mus musculus	140-144
11590213-4	2001	Similar to apoE(+/+) apoC3(-/-) mice, apoE(-/-)apoC3(-/-) mice exhibited a marked reduction in VLDL cholesterol and TG, indicating that the mechanism(s) by which apoC-III deficiency exerts its lipid-lowering effect act independent of apoE.	Thioguanine	116-118	apolipoprotein E	Mus musculus	38-42
11590213-4	2001	Similar to apoE(+/+) apoC3(-/-) mice, apoE(-/-)apoC3(-/-) mice exhibited a marked reduction in VLDL cholesterol and TG, indicating that the mechanism(s) by which apoC-III deficiency exerts its lipid-lowering effect act independent of apoE.	Thioguanine	116-118	apolipoprotein C-III	Mus musculus	47-52
11590213-4	2001	Similar to apoE(+/+) apoC3(-/-) mice, apoE(-/-)apoC3(-/-) mice exhibited a marked reduction in VLDL cholesterol and TG, indicating that the mechanism(s) by which apoC-III deficiency exerts its lipid-lowering effect act independent of apoE.	Thioguanine	116-118	apolipoprotein E	Mus musculus	38-42
11590213-6	2001	However, turnover studies showed that TG-labeled emulsion particles were cleared much more rapidly in apoC3(-/-) mice, whereas the clearance of VLDL apoB, as a marker for whole particle uptake by the liver, was not affected.	Thioguanine	38-40	apolipoprotein C-III	Mus musculus	102-107
11590213-8	2001	Thus the mechanisms underlying the hypolipidemia in apoC3(-/-) mice involve both a more efficient hydrolysis of VLDL TG as well as an enhanced selective clearance of VLDL cholesteryl esters from plasma.	Thioguanine	117-119	apolipoprotein C-III	Mus musculus	52-57
11447229-7	2001	Consistent with its ability to transport cyclic nucleotides, it is demonstrated that the MRP4 drug resistance profile extends to 6-mercaptopurine and 6-thioguanine, two anticancer purine analogs that are converted in the cell to nucleotide analogs.	Thioguanine	150-163	ATP binding cassette subfamily C member 4	Homo sapiens	89-93
11745783-5	2001	The hydrophobic core lipid volume (CE + TG) within each lipoprotein subfraction was correlated to the amount of CSA recovered in each plasma sample from the different human subjects.	Thioguanine	40-42	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	112-115
11590213-1	2001	Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of TG.	Thioguanine	172-174	apolipoprotein C-III	Mus musculus	85-105
11561778-0	2001	Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein.	Thioguanine	86-99	tumor protein p53	Homo sapiens	186-189
11470494-9	2001	Similarly, treatment of G12 cells with 5 ng/ml TSA during and after exposure to 0.3 microg Ni(3)S(2)/cm(2) reduced silencing of the gpt gene as gauged by resistance to 10 microg/ml 6-thioguanine (6-TG).	Thioguanine	181-194	glutamic--pyruvic transaminase	Homo sapiens	132-135
11470494-9	2001	Similarly, treatment of G12 cells with 5 ng/ml TSA during and after exposure to 0.3 microg Ni(3)S(2)/cm(2) reduced silencing of the gpt gene as gauged by resistance to 10 microg/ml 6-thioguanine (6-TG).	Thioguanine	196-200	glutamic--pyruvic transaminase	Homo sapiens	132-135
11479220-2	2001	Thiopurine S-methyltransferase (TPMT), an enzyme subject to genetic polymorphism, catabolizes thiopurines into inactive methylated bases, but also produces methylthioguanine nucleotides and methylmercaptopurine nucleotides from thioguanine and mercaptopurine nucleotides, respectively.	Thioguanine	162-173	thiopurine S-methyltransferase	Homo sapiens	0-30
11479220-2	2001	Thiopurine S-methyltransferase (TPMT), an enzyme subject to genetic polymorphism, catabolizes thiopurines into inactive methylated bases, but also produces methylthioguanine nucleotides and methylmercaptopurine nucleotides from thioguanine and mercaptopurine nucleotides, respectively.	Thioguanine	162-173	thiopurine S-methyltransferase	Homo sapiens	32-36
11479220-5	2001	TPMT+ cells were less sensitive to thioguanine than MOCK cells (IC(50) = 1.10+/- 0.12 microM versus 0.55 +/- 0.19 microM; P = 0.02); in contrast, TPMT+ cells were more sensitive to mercaptopurine than MOCK cells (IC(50) = 0.52 +/- 0.20 microM versus 1.50 +/- 0.23 microM; P &lt; 0.01).	Thioguanine	35-46	thiopurine S-methyltransferase	Homo sapiens	0-4
11479220-5	2001	TPMT+ cells were less sensitive to thioguanine than MOCK cells (IC(50) = 1.10+/- 0.12 microM versus 0.55 +/- 0.19 microM; P = 0.02); in contrast, TPMT+ cells were more sensitive to mercaptopurine than MOCK cells (IC(50) = 0.52 +/- 0.20 microM versus 1.50 +/- 0.23 microM; P &lt; 0.01).	Thioguanine	35-46	thiopurine S-methyltransferase	Homo sapiens	146-150
11479220-6	2001	The lower sensitivity of TPMT+ versus MOCK cells to thioguanine was associated with lower thioguanine nucleotide concentrations (917 +/- 282 versus 1515 +/- 183 pmol/5 x 10(6) cells; P = 0.01), higher methylthioguanine nucleotide concentrations (252 +/- 34 versus 27 +/- 10 pmol/5 x 10(6) cells; P = 0.01), less inhibition of de novo purine synthesis (13 versus 95%; P &lt; 0.01), and lower deoxythioguanosine incorporation into DNA (2.0 +/- 0.6% versus 7.2 +/- 2.0%; P &lt; 0.001).	Thioguanine	52-63	thiopurine S-methyltransferase	Homo sapiens	25-29
11417444-6	2001	METHODS: The assay for measurement of TPMT activity in packed red blood cells is based on a non-radioactive conversion of 6-thioguanine to 6-methylthioguanine.	Thioguanine	122-135	thiopurine S-methyltransferase	Homo sapiens	38-42
11294872-4	2001	Here, we investigated the role of two molecular chaperones, protein disulfide isomerase (PDI) and immunoglobulin heavy chain-binding protein (BiP), present in the follicular lumen, on the multimerization process due to oxidation using both native Tg and its N-terminal domain (NTD).	Thioguanine	247-249	heat shock protein family A (Hsp70) member 5	Homo sapiens	142-145
11294872-5	2001	In vitro, PDI decreased multimerization of Tg and even suppressed the formation of NTD multimers.	Thioguanine	43-45	prolyl 4-hydroxylase subunit beta	Homo sapiens	10-13
11294872-6	2001	Under the same conditions, BiP was able to bind to Tg and NTD multimers but did not affect the process of multimerization.	Thioguanine	51-53	heat shock protein family A (Hsp70) member 5	Homo sapiens	27-30
11470740-4	2001	Cell growth inhibition induced by temozolomide, 6-thioguanine and N-methyl-N"-nitro-N-nitrosoguanidine was significantly lower in the hMSH3-overexpressing HL-60R cell line as compared with the HL-60 parental line.	Thioguanine	48-61	mutS homolog 3	Homo sapiens	134-139
12600078-7	2001	CONCLUSION: The alleles epsilon 2 and epsilon 4 are associated with serum TG, TC, nHDLC, apoC II and apoE levels to some extent in type II b hyperlipide in Chinese population.	Thioguanine	74-76	apolipoprotein E	Homo sapiens	101-105
11116074-12	2000	Accordingly, FFA-induced increased expression of PAI-1 in HepG2 cells is mediated by the binding of a transcription factor or factors to the repeated fatty acid response element, 5"-TG(G/C)(1-2)CTG-3", that is highly homologous to an Sp1-binding site.	Thioguanine	182-184	serpin family E member 1	Homo sapiens	49-54
11295126-6	2001	CONCLUSION: Allele epsilon(2) of apoE gene was associated with higher serum TG and apoE levels and lower serum LDLC level, and the lower ratio of apoE/apoCIII was associated with the higher serum level of TG in endogenous HTG.	Thioguanine	76-78	apolipoprotein E	Homo sapiens	33-37
11295126-6	2001	CONCLUSION: Allele epsilon(2) of apoE gene was associated with higher serum TG and apoE levels and lower serum LDLC level, and the lower ratio of apoE/apoCIII was associated with the higher serum level of TG in endogenous HTG.	Thioguanine	76-78	apolipoprotein C3	Homo sapiens	151-158
11295126-6	2001	CONCLUSION: Allele epsilon(2) of apoE gene was associated with higher serum TG and apoE levels and lower serum LDLC level, and the lower ratio of apoE/apoCIII was associated with the higher serum level of TG in endogenous HTG.	Thioguanine	205-207	apolipoprotein E	Homo sapiens	33-37
11295126-6	2001	CONCLUSION: Allele epsilon(2) of apoE gene was associated with higher serum TG and apoE levels and lower serum LDLC level, and the lower ratio of apoE/apoCIII was associated with the higher serum level of TG in endogenous HTG.	Thioguanine	205-207	apolipoprotein C3	Homo sapiens	151-158
11239972-2	2001	The presence of radiation induced mutants was assessed by selecting the HPRT mutants every week on the basis of 6-thioguanine resistance up to 1 month after irradiation.	Thioguanine	112-125	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	72-76
11264174-6	2001	The difference between mi/mi and tg/tg mice was reproducible in the culture supplemented with interleukin-2.	Thioguanine	33-35	interleukin 2	Mus musculus	94-107
11264174-6	2001	The difference between mi/mi and tg/tg mice was reproducible in the culture supplemented with interleukin-2.	Thioguanine	36-38	interleukin 2	Mus musculus	94-107
11160733-3	2001	One isoform of human GLI-2 appears to be identical to a factor previously called Tax helper protein (THP), thus named due to its ability to interact with a TG-rich element in the human T-lymphotropic virus type 1 (HTLV-1) enhancer thought to mediate transcriptional stimulation by the Tax protein of HTLV-1.	Thioguanine	156-158	GLI family zinc finger 2	Homo sapiens	21-26
11160733-3	2001	One isoform of human GLI-2 appears to be identical to a factor previously called Tax helper protein (THP), thus named due to its ability to interact with a TG-rich element in the human T-lymphotropic virus type 1 (HTLV-1) enhancer thought to mediate transcriptional stimulation by the Tax protein of HTLV-1.	Thioguanine	156-158	uromodulin	Homo sapiens	81-99
11160733-3	2001	One isoform of human GLI-2 appears to be identical to a factor previously called Tax helper protein (THP), thus named due to its ability to interact with a TG-rich element in the human T-lymphotropic virus type 1 (HTLV-1) enhancer thought to mediate transcriptional stimulation by the Tax protein of HTLV-1.	Thioguanine	156-158	uromodulin	Homo sapiens	101-104
11179762-1	2001	The level of expression of the enzyme thiopurine methyltransferase (TPMT) is an important determinant of the metabolism of drugs used both in the treatment of acute leukaemia (6-mercaptopurine and 6-thioguanine) and as an immunosuppressant in patients with autoimmune diseases or following organ transplantation (azathioprine).	Thioguanine	197-210	thiopurine S-methyltransferase	Homo sapiens	38-66
11179762-1	2001	The level of expression of the enzyme thiopurine methyltransferase (TPMT) is an important determinant of the metabolism of drugs used both in the treatment of acute leukaemia (6-mercaptopurine and 6-thioguanine) and as an immunosuppressant in patients with autoimmune diseases or following organ transplantation (azathioprine).	Thioguanine	197-210	thiopurine S-methyltransferase	Homo sapiens	68-72
11093731-8	2000	The hepatic hydroxyproline content and serum hyaluronic acid were also significantly increased in TIMP-Tg-mice, whereas CCl(4)-induced liver dysfunction was not altered.	Thioguanine	103-105	tissue inhibitor of metalloproteinase 1	Mus musculus	98-102
11059773-0	2000	Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine.	Thioguanine	268-281	mutS homolog 2	Homo sapiens	65-69
11086052-5	2000	Such a requirement for recognition of self-determinants was mirrored in the periphery; Ealpha(6) TCR Tg naive T cells showed an impaired persistence in both H-2Malpha(-/-) and I-A(b)ss(-/-) irradiated hosts, whereas they persisted and slowly cycled in wild-type recipients.	Thioguanine	101-103	histocompatibility 2, class II, locus DMa	Mus musculus	157-166
11059773-0	2000	Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine.	Thioguanine	268-281	mutS homolog 2	Homo sapiens	146-150
11025471-1	2000	BACKGROUND: Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and thioguanine, and exhibits genetic variation.	Thioguanine	130-141	thiopurine S-methyltransferase	Homo sapiens	12-42
11025471-1	2000	BACKGROUND: Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and thioguanine, and exhibits genetic variation.	Thioguanine	130-141	thiopurine S-methyltransferase	Homo sapiens	44-48
11007234-1	2000	OBJECTIVE: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the inactivation of mercaptopurine, azathioprine, and thioguanine.	Thioguanine	140-151	thiopurine S-methyltransferase	Homo sapiens	11-41
10993211-1	2000	Thiopurine methyltransferase (TPMT) catalyzes the metabolism of important drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	106-119	thiopurine S-methyltransferase	Homo sapiens	0-28
10993211-1	2000	Thiopurine methyltransferase (TPMT) catalyzes the metabolism of important drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine.	Thioguanine	106-119	thiopurine S-methyltransferase	Homo sapiens	30-34
11007234-1	2000	OBJECTIVE: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the inactivation of mercaptopurine, azathioprine, and thioguanine.	Thioguanine	140-151	thiopurine S-methyltransferase	Homo sapiens	43-47
10910933-1	2000	Three French families with triose phosphate isomerase (TPI) deficiency were studied, and 2 new mutations giving rise to null alleles were observed: a frameshift mutation with deletion of the 86-87 TG dinucleotide in codon 29 (TPI Alfortville) and a T--&gt;A transversion in nucleotide 2 of the initiation codon (TPI Paris).	Thioguanine	197-199	triosephosphate isomerase 1	Homo sapiens	27-53
10966494-5	2000	Expansion of the mesangial area and increase in the intraglomerular cell number were also inhibited in BNP-Tg.	Thioguanine	107-109	natriuretic peptide type B	Mus musculus	103-106
10966494-6	2000	Glomerular expressions of transforming growth factor-beta and fibronectin were increased with hypertrophy and were significantly suppressed in BNP-Tg.	Thioguanine	147-149	fibronectin 1	Mus musculus	62-73
10966494-6	2000	Glomerular expressions of transforming growth factor-beta and fibronectin were increased with hypertrophy and were significantly suppressed in BNP-Tg.	Thioguanine	147-149	natriuretic peptide type B	Mus musculus	143-146
10966494-7	2000	Furthermore, increases in the urinary albumin excretion and BP were significantly ameliorated in BNP-Tg.	Thioguanine	101-103	natriuretic peptide type B	Mus musculus	97-100
11037857-0	2000	Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency.	Thioguanine	7-20	thiopurine S-methyltransferase	Homo sapiens	103-131
11037857-2	2000	Just as with 6-mercaptopurine (6MP), it is be expected that 6TG would cause pancytopenia in individuals with inherited thiopurine methyltransferase (TPMT) deficiency.	Thioguanine	60-63	thiopurine S-methyltransferase	Homo sapiens	119-147
10910933-1	2000	Three French families with triose phosphate isomerase (TPI) deficiency were studied, and 2 new mutations giving rise to null alleles were observed: a frameshift mutation with deletion of the 86-87 TG dinucleotide in codon 29 (TPI Alfortville) and a T--&gt;A transversion in nucleotide 2 of the initiation codon (TPI Paris).	Thioguanine	197-199	triosephosphate isomerase 1	Homo sapiens	55-58
10954350-0	2000	Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S-methyltransferase.	Thioguanine	36-49	thiopurine S-methyltransferase	Homo sapiens	53-83
10959799-13	2000	Induction of NFkappaB, caused by increased endogenous production of TNFalpha, is a possible explanation of decreased FB1 hepatotoxicity in TG.	Thioguanine	139-141	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	13-21
10959799-13	2000	Induction of NFkappaB, caused by increased endogenous production of TNFalpha, is a possible explanation of decreased FB1 hepatotoxicity in TG.	Thioguanine	139-141	tumor necrosis factor	Mus musculus	68-76
10954350-2	2000	OBJECTIVES: To compare 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) as substrates for the methylation reaction catalysed by the enzyme thiopurine S-methyltransferase (TPMT).	Thioguanine	51-64	thiopurine S-methyltransferase	Homo sapiens	139-169
10954350-2	2000	OBJECTIVES: To compare 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) as substrates for the methylation reaction catalysed by the enzyme thiopurine S-methyltransferase (TPMT).	Thioguanine	66-70	thiopurine S-methyltransferase	Homo sapiens	139-169
10954350-2	2000	OBJECTIVES: To compare 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) as substrates for the methylation reaction catalysed by the enzyme thiopurine S-methyltransferase (TPMT).	Thioguanine	66-70	thiopurine S-methyltransferase	Homo sapiens	171-175
10954350-3	2000	METHODS: TPMT activity in haemolysed red blood cells of healthy blood donors was determined twice, using the same experimental setting and equal molar concentrations of 6-TG and 6-MP as substrates.	Thioguanine	169-173	thiopurine S-methyltransferase	Homo sapiens	9-13
10954350-5	2000	RESULTS: The medians of the TPMT activities from 199 blood donors were 54.4 nmol 6-MTG g(-1)Hb h(-1) when measured with 6-TG as the substrate and 35.8 nmol 6-MMP g(-1) Hb h(-1) when measured with 6-MP.	Thioguanine	120-124	thiopurine S-methyltransferase	Homo sapiens	28-32
10954350-7	2000	On average, TPMT activity was 34% lower with 6-MP as substrate than with 6-TG as substrate.	Thioguanine	73-77	thiopurine S-methyltransferase	Homo sapiens	12-16
10760286-8	2000	However, the frequencies of 6-thioguanine resistance mutants induced by UV in the cells expressing antisense hREV1 RNA were significantly lower than in the control (P = 0.01), suggesting that the human gene has a function similar to that of the yeast homolog.	Thioguanine	28-41	REV1 DNA directed polymerase	Homo sapiens	109-114
10839990-8	2000	In the human fibroblast cell line HT1080HPRT(-) (that is deficient in the enzyme for hypoxanthine-guanine phosphoribosyltransferase) cells in which interaction between both proteins of interest occurs can then be selected for by hypoxanthine/aminopterin/thymine medium and counterselected against by 6-thioguanine medium.	Thioguanine	300-313	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	85-131
10849375-3	2000	Mutations of the hypoxanthine guanine phosphoribosyltransferase (hprt) gene measured by 6-thioguanine (TG) selection were studied in 28 patients (60 determinations) enrolled in a prospective double-blinded placebo-controlled study of azathioprine immunosuppression: 17 patients (34 determinations) were receiving azathioprine and 11 (26 determinations) placebo.	Thioguanine	88-101	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-63
10849375-3	2000	Mutations of the hypoxanthine guanine phosphoribosyltransferase (hprt) gene measured by 6-thioguanine (TG) selection were studied in 28 patients (60 determinations) enrolled in a prospective double-blinded placebo-controlled study of azathioprine immunosuppression: 17 patients (34 determinations) were receiving azathioprine and 11 (26 determinations) placebo.	Thioguanine	88-101	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	65-69
10849375-3	2000	Mutations of the hypoxanthine guanine phosphoribosyltransferase (hprt) gene measured by 6-thioguanine (TG) selection were studied in 28 patients (60 determinations) enrolled in a prospective double-blinded placebo-controlled study of azathioprine immunosuppression: 17 patients (34 determinations) were receiving azathioprine and 11 (26 determinations) placebo.	Thioguanine	103-105	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-63
10849375-3	2000	Mutations of the hypoxanthine guanine phosphoribosyltransferase (hprt) gene measured by 6-thioguanine (TG) selection were studied in 28 patients (60 determinations) enrolled in a prospective double-blinded placebo-controlled study of azathioprine immunosuppression: 17 patients (34 determinations) were receiving azathioprine and 11 (26 determinations) placebo.	Thioguanine	103-105	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	65-69
10685028-9	2000	The association constant K(a) and apolipoprotein (apo) E/apoB mole ratio values all increased significantly for VLDL, but not for LDL, in comparison of the TG(i+h) with the TG(l) group.	Thioguanine	156-158	apolipoprotein B	Homo sapiens	57-61
10734022-1	2000	BACKGROUND &amp; AIMS: The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) nucleotide metabolites, the latter genetically controlled by thiopurine methyltransferase (TPMT).	Thioguanine	111-124	thiopurine S-methyltransferase	Homo sapiens	228-256
10734022-1	2000	BACKGROUND &amp; AIMS: The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) nucleotide metabolites, the latter genetically controlled by thiopurine methyltransferase (TPMT).	Thioguanine	111-124	thiopurine S-methyltransferase	Homo sapiens	258-262
10734022-1	2000	BACKGROUND &amp; AIMS: The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) nucleotide metabolites, the latter genetically controlled by thiopurine methyltransferase (TPMT).	Thioguanine	126-130	thiopurine S-methyltransferase	Homo sapiens	228-256
10734022-1	2000	BACKGROUND &amp; AIMS: The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) nucleotide metabolites, the latter genetically controlled by thiopurine methyltransferase (TPMT).	Thioguanine	126-130	thiopurine S-methyltransferase	Homo sapiens	258-262
10734022-8	2000	Patients heterozygous for TPMT (8/92) had higher 6-TG levels (P &lt; 0.0001), and all responded to therapy.	Thioguanine	49-53	thiopurine S-methyltransferase	Homo sapiens	26-30
10764140-1	2000	Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, including 6-mercaptopurine and 6-thioguanine.	Thioguanine	111-124	thiopurine S-methyltransferase	Homo sapiens	0-28
10764140-1	2000	Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, including 6-mercaptopurine and 6-thioguanine.	Thioguanine	111-124	thiopurine S-methyltransferase	Homo sapiens	30-34
10751626-1	2000	Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine.	Thioguanine	110-123	thiopurine S-methyltransferase	Homo sapiens	0-28
10751626-1	2000	Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathiopurine.	Thioguanine	110-123	thiopurine S-methyltransferase	Homo sapiens	30-34
10728688-11	2000	A concomitant increase of mutation frequency at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus, assessed by colony formation assay in the presence of 6-thioguanine, was detected after 40 h-range, 16 to 45 x 10(-6) compared with 12 x 10(-6) in cultures without PhIP.	Thioguanine	168-181	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	52-99
10728688-11	2000	A concomitant increase of mutation frequency at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus, assessed by colony formation assay in the presence of 6-thioguanine, was detected after 40 h-range, 16 to 45 x 10(-6) compared with 12 x 10(-6) in cultures without PhIP.	Thioguanine	168-181	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	101-105
10719032-5	2000	The induction of mutations in the HPRT locus was studied by selection in medium containing 6-thioguanine.	Thioguanine	91-104	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	34-38
10685028-9	2000	The association constant K(a) and apolipoprotein (apo) E/apoB mole ratio values all increased significantly for VLDL, but not for LDL, in comparison of the TG(i+h) with the TG(l) group.	Thioguanine	173-175	apolipoprotein B	Homo sapiens	57-61
10685028-11	2000	The functional dependences of K(a)(VLDL), IC(50) and apoE content in VLDL (both fractional and absolute) and in serum on TG content in the whole concentration range studied were fitted to a saturation model.	Thioguanine	121-123	apolipoprotein E	Homo sapiens	53-57
11521687-4	2000	Serum leptin was elevated in those with hyper-cholesterolemia (C; &gt; or =220 mg/dl) and triglyceridemia (TG; &gt; or =150 mg/dl) compared with the normolipidemia (9.4+/-0.4 vs 7.8+/-0.3; 11.7+/-0.6 vs 7.5+/-0.2 ng/ml, both p &lt;0.001).	Thioguanine	107-109	leptin	Homo sapiens	6-12
10940339-1	2000	Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major determinant of fatty acid mobilization in adipose tissue as well as other tissues.	Thioguanine	68-70	lipase E, hormone sensitive type	Homo sapiens	0-24
11001588-9	2000	poly(TG), in a process strongly stimulated by the nuclear proteins HMG1 and HMG2.	Thioguanine	5-7	high mobility group box 1 pseudogene 5	Homo sapiens	67-71
11001588-9	2000	poly(TG), in a process strongly stimulated by the nuclear proteins HMG1 and HMG2.	Thioguanine	5-7	high mobility group box 2	Homo sapiens	76-80
10601244-3	1999	To test this hypothesis we cross-bred LCAT-Tg with CETP-Tg mice.	Thioguanine	43-45	lecithin cholesterol acyltransferase	Mus musculus	38-42
10594017-3	2000	ES cells homozygous for the Msh2 mutation displayed increased resistance to killing by the cytotoxic drug 6-thioguanine (6TG), indicating that the 6TG cytotoxic mechanism is mediated by Msh2.	Thioguanine	106-119	mutS homolog 2	Mus musculus	28-32
10594017-3	2000	ES cells homozygous for the Msh2 mutation displayed increased resistance to killing by the cytotoxic drug 6-thioguanine (6TG), indicating that the 6TG cytotoxic mechanism is mediated by Msh2.	Thioguanine	106-119	mutS homolog 2	Mus musculus	186-190
10594017-3	2000	ES cells homozygous for the Msh2 mutation displayed increased resistance to killing by the cytotoxic drug 6-thioguanine (6TG), indicating that the 6TG cytotoxic mechanism is mediated by Msh2.	Thioguanine	121-124	mutS homolog 2	Mus musculus	28-32
10594017-3	2000	ES cells homozygous for the Msh2 mutation displayed increased resistance to killing by the cytotoxic drug 6-thioguanine (6TG), indicating that the 6TG cytotoxic mechanism is mediated by Msh2.	Thioguanine	121-124	mutS homolog 2	Mus musculus	186-190
11043513-1	2000	Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of drugs such as azathiopurine, 6-mercaptopurine, and 6-thioguanine, which are widely prescribed for immunosuppressive or cytotoxic applications.	Thioguanine	120-133	thiopurine S-methyltransferase	Homo sapiens	0-30
11043513-1	2000	Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of drugs such as azathiopurine, 6-mercaptopurine, and 6-thioguanine, which are widely prescribed for immunosuppressive or cytotoxic applications.	Thioguanine	120-133	thiopurine S-methyltransferase	Homo sapiens	32-36
10718282-6	2000	RESULTS: In CR1-A and CR1-B dyslipoproteinemia was found at different stages of renal insufficiency which was manifested by the significant increase of TG, TC, LDL-C, apo B levels and TC/HDL-C, LDL-C/HDL-C ratios and significant decrease of HDL-C level and apo AI/apoB, HDL-C/apoAI ratios in comparison with controls.	Thioguanine	152-154	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	12-15
10718282-6	2000	RESULTS: In CR1-A and CR1-B dyslipoproteinemia was found at different stages of renal insufficiency which was manifested by the significant increase of TG, TC, LDL-C, apo B levels and TC/HDL-C, LDL-C/HDL-C ratios and significant decrease of HDL-C level and apo AI/apoB, HDL-C/apoAI ratios in comparison with controls.	Thioguanine	152-154	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	22-25
10601244-4	1999	On both regular chow and high fat, high cholesterol diets, expression of CETP in LCAT-Tg mice reduced total cholesterol (-39% and -13%, respectively; p &lt; 0.05), reflecting a decrease in HDL cholesterol levels.	Thioguanine	86-88	lecithin cholesterol acyltransferase	Mus musculus	81-85
10601244-5	1999	CETP normalized both the plasma clearance of [(3)H]cholesteryl esters ([(3)H]CE) from HDL (fractional catabolic rate in days(-1): LCAT-Tg = 3.7 +/- 0.34, LCATxCETP-Tg = 6.1 +/- 0.16, and controls = 6.4 +/- 0.16) as well as the liver uptake of [(3)H]CE from HDL (LCAT-Tg = 36%, LCATxCETP-Tg = 65%, and controls = 63%) in LCAT-Tg mice.	Thioguanine	135-137	lecithin cholesterol acyltransferase	Mus musculus	130-134
10601244-8	1999	Thus, the ability of SR-BI to facilitate the selective uptake of CE from LCAT-Tg HDL is impaired, indicating a potential mechanism leading to impaired reverse cholesterol transport and atherosclerosis in these animals.	Thioguanine	78-80	scavenger receptor class B, member 1	Mus musculus	21-26
10601244-8	1999	Thus, the ability of SR-BI to facilitate the selective uptake of CE from LCAT-Tg HDL is impaired, indicating a potential mechanism leading to impaired reverse cholesterol transport and atherosclerosis in these animals.	Thioguanine	78-80	lecithin cholesterol acyltransferase	Mus musculus	73-77
10404070-2	1999	This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSalpha, is resistant to low doses of 6-TG.	Thioguanine	130-134	mutS homolog 2	Homo sapiens	28-33
10635988-1	1999	The T-cell cloning assay, which enables the enumeration and molecular analysis of 6-thioguanine resistant (HPRT-negative) mutant T-cells, has been extensively used for studying human somatic gene mutation in vivo.	Thioguanine	82-95	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	107-111
10635989-1	1999	6-Thioguanine-resistant (TGR) mutant lymphocytes in human blood are usually enumerated by the cloning assay which allows the molecular characterisation of the HPRT mutations to be detected.	Thioguanine	0-13	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	159-163
10635993-1	1999	We studied mutations in exon 3 of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in 113 6-thioguanine-resistant T-cell clones derived from coke-oven workers and control subjects in order to analyse possible changes in the mutational spectrum associated with the exposure to polycyclic aromatic hydrocarbons (PAHs).	Thioguanine	105-118	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	38-84
10635993-1	1999	We studied mutations in exon 3 of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in 113 6-thioguanine-resistant T-cell clones derived from coke-oven workers and control subjects in order to analyse possible changes in the mutational spectrum associated with the exposure to polycyclic aromatic hydrocarbons (PAHs).	Thioguanine	105-118	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	86-90
10636001-4	1999	The frequency of hypoxanthine-guanine-phosphoribosyltransferase (HPRT) mutant lymphocytes measured as 6-thioguanine resistant variant cells by 5-bromodeoxyuridine labeling, was elevated eight-fold, from 4.7 x 10(-6) to 36.2 x 10(-6) (p = 0.008) after termination of the radiotherapy, thus showing a clear response to the radiation treatment.	Thioguanine	102-115	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-63
10636001-4	1999	The frequency of hypoxanthine-guanine-phosphoribosyltransferase (HPRT) mutant lymphocytes measured as 6-thioguanine resistant variant cells by 5-bromodeoxyuridine labeling, was elevated eight-fold, from 4.7 x 10(-6) to 36.2 x 10(-6) (p = 0.008) after termination of the radiotherapy, thus showing a clear response to the radiation treatment.	Thioguanine	102-115	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	65-69
10636005-4	1999	Among a total of 138 independent mutant clones that had resulted from 55 separate cultures, 60 point mutations were identified within the hypoxanthine guanine phosphoribosyltransferase (HPRT) reading frame by sequencing full-size reverse transcription polymerase chain reaction (RT-PCR) products from thioguanine-resistant clones.	Thioguanine	301-312	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	138-184
10636005-4	1999	Among a total of 138 independent mutant clones that had resulted from 55 separate cultures, 60 point mutations were identified within the hypoxanthine guanine phosphoribosyltransferase (HPRT) reading frame by sequencing full-size reverse transcription polymerase chain reaction (RT-PCR) products from thioguanine-resistant clones.	Thioguanine	301-312	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	186-190
10547523-2	1999	poly(TG) can associate in vitro to form stable complexes of low electrophoretic mobility, which are recognized with high specificity by proteins HMG1 and HMG2.	Thioguanine	5-7	high mobility group box 1 pseudogene 5	Homo sapiens	145-149
10547523-2	1999	poly(TG) can associate in vitro to form stable complexes of low electrophoretic mobility, which are recognized with high specificity by proteins HMG1 and HMG2.	Thioguanine	5-7	high mobility group box 2	Homo sapiens	154-158
10638213-4	1999	However, although the mutation of LPL gene results in reduced lipolytic activity, this type of dyslipidemia appears to manifest only if VLDL-TG production is also increased.	Thioguanine	141-143	lipoprotein lipase	Homo sapiens	34-37
10634140-1	1999	Thiopurine methyltransferase (TPMT) degrades 6-mercaptopurine, azathioprine and 6-thioguanine which are commonly used in the treatment of autoimmune diseases, leukaemia and organ transplantation.	Thioguanine	80-93	thiopurine S-methyltransferase	Homo sapiens	0-28
10634140-1	1999	Thiopurine methyltransferase (TPMT) degrades 6-mercaptopurine, azathioprine and 6-thioguanine which are commonly used in the treatment of autoimmune diseases, leukaemia and organ transplantation.	Thioguanine	80-93	thiopurine S-methyltransferase	Homo sapiens	30-34
10581347-6	1999	4G/5G polymorphism, diabetes mellitus and triglyceride(TG) were three independent predictors of plasma PAI-1 levels in a stepwise multiple regression model.	Thioguanine	55-57	serpin family E member 1	Homo sapiens	103-108
10630211-7	1999	In contrast, removal of cerebellar Purkinje cells with the Purkinje cell degeneration (pcd) mutation by generation of tg/tg; pcd/pcd double mutant mice completely eliminated tottering mouse dystonia.	Thioguanine	118-120	ATP/GTP binding protein 1	Mus musculus	59-85
10630211-7	1999	In contrast, removal of cerebellar Purkinje cells with the Purkinje cell degeneration (pcd) mutation by generation of tg/tg; pcd/pcd double mutant mice completely eliminated tottering mouse dystonia.	Thioguanine	121-123	ATP/GTP binding protein 1	Mus musculus	59-85
10582542-11	1999	CET and specific CETP activity remain significantly different in TG-matched patients and controls and are more strongly interrelated (r = -.71, P &lt; .001), suggesting a higher and selective influence of lipid transfer inhibitor(s) on CET and CETP activity in the patients.	Thioguanine	65-67	cholesteryl ester transfer protein	Homo sapiens	17-21
10521282-4	1999	For the target sequence (AAAT)(5)AA, in which pyrimidines are positioned at every fourth residue, triplex formation with TG-containing oligonucleotides is only detected in the presence of a triplex-binding ligand, though stable triplexes were detected at the target site (AAAAAT)(3)AAAA.	Thioguanine	121-123	solute carrier family 1 member 5	Homo sapiens	25-29
12212275-3	1999	Serum TG concentrations of hyperlipidemics showed positive correlation with pre-beta 1 HDL (r = 0.582) and HDL3a (r = 0.692) and negative correlation with HDL2b (r = -0.506) and HDL2a (r = -0.552).	Thioguanine	6-8	junctophilin 3	Homo sapiens	155-159
10484613-0	1999	Delayed clearance of postprandial large TG-rich particles in normolipidemic carriers of LPL Asn291Ser gene variant.	Thioguanine	40-42	lipoprotein lipase	Homo sapiens	88-91
10365782-7	1999	Here we describe a method employing hypotonic shock and micrococcal nuclease that reliably eliminates non-viable 6-TG-sensitive cells, allowing the study of the hprt gene in &lt; 200 T cells by PCR.	Thioguanine	113-117	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	161-165
10424321-1	1999	OBJECTIVES: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6-thioguanine (6-TG) as substrate, could not be reproduced in another laboratory.	Thioguanine	151-164	thiopurine S-methyltransferase	Homo sapiens	12-42
10424321-1	1999	OBJECTIVES: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6-thioguanine (6-TG) as substrate, could not be reproduced in another laboratory.	Thioguanine	151-164	thiopurine S-methyltransferase	Homo sapiens	44-48
10424321-1	1999	OBJECTIVES: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6-thioguanine (6-TG) as substrate, could not be reproduced in another laboratory.	Thioguanine	151-164	thiopurine S-methyltransferase	Homo sapiens	125-129
10424321-1	1999	OBJECTIVES: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6-thioguanine (6-TG) as substrate, could not be reproduced in another laboratory.	Thioguanine	166-170	thiopurine S-methyltransferase	Homo sapiens	12-42
10424321-1	1999	OBJECTIVES: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6-thioguanine (6-TG) as substrate, could not be reproduced in another laboratory.	Thioguanine	166-170	thiopurine S-methyltransferase	Homo sapiens	44-48
10424321-1	1999	OBJECTIVES: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6-thioguanine (6-TG) as substrate, could not be reproduced in another laboratory.	Thioguanine	166-170	thiopurine S-methyltransferase	Homo sapiens	125-129
10424321-4	1999	Furthermore, we studied the influence of different 6-TG compounds on the affinity of the methyl donor S-adenosyl-L-methionine (SAM) to the TPMT enzyme.	Thioguanine	51-55	thiopurine S-methyltransferase	Homo sapiens	139-143
10424321-8	1999	From these results we assume that there is a contaminant in some 6-TG products, which acts as a strong inhibitor of TPMT activity.	Thioguanine	67-69	thiopurine S-methyltransferase	Homo sapiens	116-120
10424321-14	1999	CONCLUSIONS: TPMT enzyme activity determined with 6-TG as substrate may be strongly inhibited by a contaminant in some of the 6-TG lots distributed.	Thioguanine	50-54	thiopurine S-methyltransferase	Homo sapiens	13-17
10424321-14	1999	CONCLUSIONS: TPMT enzyme activity determined with 6-TG as substrate may be strongly inhibited by a contaminant in some of the 6-TG lots distributed.	Thioguanine	126-130	thiopurine S-methyltransferase	Homo sapiens	13-17
10348147-8	1999	Cytotoxicity of cytarabine and thioguanine was significantly increased by IL-7, that of thioguanine by IL-3 as well.	Thioguanine	31-42	interleukin 7	Homo sapiens	74-78
10447710-5	1999	Competitive reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that the mRNAs of the I-Ealpha chain on the SI epithelial cells was higher in KN 6 Tg than in non-Tg littermates.	Thioguanine	168-170	histocompatibility 2, class II antigen E alpha	Mus musculus	107-115
10224323-4	1999	Mutations induced at the gpt gene can be easily detected with a selective agent, 6-thioguanine (6-TG).	Thioguanine	81-94	glutamic pyruvic transaminase, soluble	Mus musculus	25-28
10224323-4	1999	Mutations induced at the gpt gene can be easily detected with a selective agent, 6-thioguanine (6-TG).	Thioguanine	96-100	glutamic pyruvic transaminase, soluble	Mus musculus	25-28
10213489-6	1999	In contrast to the well-characterized, marked increase in cytotoxicity (&gt; 1 log cell kill) found with 6-thioguanine exposures in HCT116/3-6 (hMLH1+) cells compared to HCT116 (hMLH1-) cells, we found only modest cytotoxicity (10-20% cell kill) in both cell lines when treated with IdUrd or BrdUrd for 1 population doubling.	Thioguanine	105-118	mutL homolog 1	Homo sapiens	144-149
10348147-8	1999	Cytotoxicity of cytarabine and thioguanine was significantly increased by IL-7, that of thioguanine by IL-3 as well.	Thioguanine	31-42	interleukin 3	Homo sapiens	103-107
10348147-8	1999	Cytotoxicity of cytarabine and thioguanine was significantly increased by IL-7, that of thioguanine by IL-3 as well.	Thioguanine	88-99	interleukin 3	Homo sapiens	103-107
10348147-9	1999	IL-7 enhanced the cytotoxicity of thioguanine significantly more than IL-3 and lmw-BCGF and that of cytarabine more than IL-3.	Thioguanine	34-45	interleukin 7	Homo sapiens	0-4
10049727-3	1999	Regarding the colloidal insoluble multimerized Tg (m-Tg), which bears dityrosine bridges and is present in the follicular lumen, a mild oxidative system generated different soluble forms of Tg, more or less compacted by hydrophobic associations, and linked with Grp78 and Grp94.	Thioguanine	47-49	heat shock protein family A (Hsp70) member 5	Homo sapiens	262-267
10073979-12	1999	Short-term experiments with radiolabeled lipoproteins and either partially purified or homogenous CETP confirmed these observations and further demonstrated that CETP has a strong predilection to mediate homoexchange (bidirectional transfer of the same lipid) rather than heteroexchange (CE for TG); LTIP had no effect on the selection of CE or TG by CETP or its mechanism of action.	Thioguanine	295-297	cholesteryl ester transfer protein	Homo sapiens	162-166
10073979-12	1999	Short-term experiments with radiolabeled lipoproteins and either partially purified or homogenous CETP confirmed these observations and further demonstrated that CETP has a strong predilection to mediate homoexchange (bidirectional transfer of the same lipid) rather than heteroexchange (CE for TG); LTIP had no effect on the selection of CE or TG by CETP or its mechanism of action.	Thioguanine	295-297	cholesteryl ester transfer protein	Homo sapiens	162-166
10073979-12	1999	Short-term experiments with radiolabeled lipoproteins and either partially purified or homogenous CETP confirmed these observations and further demonstrated that CETP has a strong predilection to mediate homoexchange (bidirectional transfer of the same lipid) rather than heteroexchange (CE for TG); LTIP had no effect on the selection of CE or TG by CETP or its mechanism of action.	Thioguanine	345-347	cholesteryl ester transfer protein	Homo sapiens	162-166
10073979-12	1999	Short-term experiments with radiolabeled lipoproteins and either partially purified or homogenous CETP confirmed these observations and further demonstrated that CETP has a strong predilection to mediate homoexchange (bidirectional transfer of the same lipid) rather than heteroexchange (CE for TG); LTIP had no effect on the selection of CE or TG by CETP or its mechanism of action.	Thioguanine	345-347	cholesteryl ester transfer protein	Homo sapiens	162-166
10213363-3	1999	TPMT, which exhibits autosomal co-dominant polymorphism, plays an important role in metabolism of the antileukemic and immunosuppressive medications, mercaptopurine, thioguanine, and azathioprine.	Thioguanine	166-177	thiopurine S-methyltransferase	Homo sapiens	0-4
10049727-3	1999	Regarding the colloidal insoluble multimerized Tg (m-Tg), which bears dityrosine bridges and is present in the follicular lumen, a mild oxidative system generated different soluble forms of Tg, more or less compacted by hydrophobic associations, and linked with Grp78 and Grp94.	Thioguanine	47-49	heat shock protein 90 beta family member 1	Homo sapiens	272-277
10049727-4	1999	In vitro, the combined action of ROS and PDI, in the presence of free glutathione (reduced/oxidized), increased the solubility of this misassembled Tg and partially restored the ability of Tg to synthesize hormones.	Thioguanine	148-150	peptidyl arginine deiminase 1	Homo sapiens	41-44
10049727-4	1999	In vitro, the combined action of ROS and PDI, in the presence of free glutathione (reduced/oxidized), increased the solubility of this misassembled Tg and partially restored the ability of Tg to synthesize hormones.	Thioguanine	189-191	peptidyl arginine deiminase 1	Homo sapiens	41-44
9891004-4	1999	LDLR1/SR-BI Tg mice showed decreases in VLDL, LDL, and HDL cholesterol and a significant 80% decrease in mean lesion area in the aortic root compared with LDLR1 mice (female LDLR1 74, 120 micrometers(2) versus LDLR1/SR-BI Tg 12, 667 micrometers(2); male 25, 747 micrometers(2)++ versus 5, 448 micrometers(2), respectively).	Thioguanine	12-14	scavenger receptor class B, member 1	Mus musculus	6-11
9931345-1	1999	Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercapto-purine, 6-thioguanine and azathioprine.	Thioguanine	111-124	thiopurine S-methyltransferase	Homo sapiens	0-28
9931345-1	1999	Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercapto-purine, 6-thioguanine and azathioprine.	Thioguanine	111-124	thiopurine S-methyltransferase	Homo sapiens	30-34
9973196-4	1999	Expression of hMLH1 restored normal levels of mPMS2 protein, reduced spontaneous base substitution and microsatellite mutations, increased sensitivity to the toxic effects of 6-thioguanine (6-TG), and restored 6-TG-induced cell cycle arrest.	Thioguanine	175-188	mutL homolog 1	Homo sapiens	14-19
9973196-4	1999	Expression of hMLH1 restored normal levels of mPMS2 protein, reduced spontaneous base substitution and microsatellite mutations, increased sensitivity to the toxic effects of 6-thioguanine (6-TG), and restored 6-TG-induced cell cycle arrest.	Thioguanine	190-194	mutL homolog 1	Homo sapiens	14-19
9973196-4	1999	Expression of hMLH1 restored normal levels of mPMS2 protein, reduced spontaneous base substitution and microsatellite mutations, increased sensitivity to the toxic effects of 6-thioguanine (6-TG), and restored 6-TG-induced cell cycle arrest.	Thioguanine	210-214	mutL homolog 1	Homo sapiens	14-19
9973196-5	1999	Our studies confirm that hMLH1 has an essential role in the maintenance of genomic stability and the potentiation of 6-TG cytotoxicity and provide a system for detailed structure/function analysis of the hMLH1 protein.	Thioguanine	117-121	mutL homolog 1	Homo sapiens	25-30
10029690-7	1999	In comparison, the frequency of Hprt mutant lymphocytes, as measured by resistance to 6-thioguanine, was 2.0+/-1.2x10-6 in control animals and 84+/-28x10-6 in the ENU-treated mice.	Thioguanine	86-99	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	32-36
9891004-4	1999	LDLR1/SR-BI Tg mice showed decreases in VLDL, LDL, and HDL cholesterol and a significant 80% decrease in mean lesion area in the aortic root compared with LDLR1 mice (female LDLR1 74, 120 micrometers(2) versus LDLR1/SR-BI Tg 12, 667 micrometers(2); male 25, 747 micrometers(2)++ versus 5, 448 micrometers(2), respectively).	Thioguanine	12-14	CD320 antigen	Mus musculus	40-44
9891004-5	1999	LDLR0/SR-BI Tg mice showed decreased LDL and HDL cholesterol but increased VLDL cholesterol and no significant difference in extent of atherosclerosis compared with LDLR0 mice.	Thioguanine	12-14	scavenger receptor class B, member 1	Mus musculus	6-11
9891004-5	1999	LDLR0/SR-BI Tg mice showed decreased LDL and HDL cholesterol but increased VLDL cholesterol and no significant difference in extent of atherosclerosis compared with LDLR0 mice.	Thioguanine	12-14	CD320 antigen	Mus musculus	75-79
10217066-1	1999	We tested the ability of a series of known genotoxic agents to cause mutations at the hprt locus in peripheral blood T-lymphocytes of cynomolgus monkeys as measured by the ability to form clones in the presence of 6-thioguanine.	Thioguanine	214-227	hypoxanthine-guanine phosphoribosyltransferase	Macaca fascicularis	86-90
10500809-0	1999	Comparison of BCL-2 and BAX protein expression with in vitro sensitivity to ARA-C and 6TG in AML.	Thioguanine	86-89	BCL2 apoptosis regulator	Homo sapiens	14-19
10500809-0	1999	Comparison of BCL-2 and BAX protein expression with in vitro sensitivity to ARA-C and 6TG in AML.	Thioguanine	86-89	BCL2 associated X, apoptosis regulator	Homo sapiens	24-27
10462721-4	1999	ENU-induced mutant frequencies in the Hprt gene, determined by measuring 6-thioguanine-resistant (TG(r)) lymphocytes, were similar to the Tk mutant frequencies.	Thioguanine	73-86	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	38-42
10595595-7	1999	We conclude that two weeks" administration of the beta3-adrenoreceptor agonist UL-TG 307 in a daily dose of 24 mg did not lead to any significant effect in diet treated type 2 diabetic patients.	Thioguanine	82-84	adrenoceptor beta 3	Homo sapiens	50-70
9888641-5	1998	Although the regulation of NEFA release in the postabsorptive state is well understood in molecular terms, the predominant pathway for release of NEFA in the postprandial state is the action of lipoprotein lipase (LPL) in adipose tissue capillaries on chylomicron-triacylglycerol (TG).	Thioguanine	281-283	lipoprotein lipase	Homo sapiens	194-212
9830042-3	1998	On a chow diet SR-BI transgenic (SR-BI Tg) mice have decreased HDL-CE, apoA-I, and apoA-II levels; plasma triglycerides, low density lipoprotein (LDL) cholesterol, and very low density lipoprotein (VLDL) and LDL apoB were also decreased, compared with control mice.	Thioguanine	39-41	scavenger receptor class B, member 1	Mus musculus	15-20
9830042-3	1998	On a chow diet SR-BI transgenic (SR-BI Tg) mice have decreased HDL-CE, apoA-I, and apoA-II levels; plasma triglycerides, low density lipoprotein (LDL) cholesterol, and very low density lipoprotein (VLDL) and LDL apoB were also decreased, compared with control mice.	Thioguanine	39-41	scavenger receptor class B, member 1	Mus musculus	33-38
9830042-3	1998	On a chow diet SR-BI transgenic (SR-BI Tg) mice have decreased HDL-CE, apoA-I, and apoA-II levels; plasma triglycerides, low density lipoprotein (LDL) cholesterol, and very low density lipoprotein (VLDL) and LDL apoB were also decreased, compared with control mice.	Thioguanine	39-41	apolipoprotein A-I	Mus musculus	71-77
9830042-3	1998	On a chow diet SR-BI transgenic (SR-BI Tg) mice have decreased HDL-CE, apoA-I, and apoA-II levels; plasma triglycerides, low density lipoprotein (LDL) cholesterol, and very low density lipoprotein (VLDL) and LDL apoB were also decreased, compared with control mice.	Thioguanine	39-41	apolipoprotein A-II	Mus musculus	83-90
9888641-5	1998	Although the regulation of NEFA release in the postabsorptive state is well understood in molecular terms, the predominant pathway for release of NEFA in the postprandial state is the action of lipoprotein lipase (LPL) in adipose tissue capillaries on chylomicron-triacylglycerol (TG).	Thioguanine	281-283	lipoprotein lipase	Homo sapiens	214-217
9855005-0	1998	Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus.	Thioguanine	14-27	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	137-141
9792672-7	1998	In PC12 cells, others have shown that 6-TG blocks nerve growth factor-induced neurite outgrowth and selectively inhibits the activity of protein kinase N, a partially characterized, nerve growth factor-inducible serine-threonine kinase.	Thioguanine	38-42	myotrophin	Rattus norvegicus	56-69
9792672-7	1998	In PC12 cells, others have shown that 6-TG blocks nerve growth factor-induced neurite outgrowth and selectively inhibits the activity of protein kinase N, a partially characterized, nerve growth factor-inducible serine-threonine kinase.	Thioguanine	38-42	myotrophin	Rattus norvegicus	188-201
9813288-5	1998	Following glucose infusion, the rate of glucose clearance from the blood of Tg-PFKL mice was significantly slower than that of control ntg mice, although the basal blood glucose levels were similar.	Thioguanine	76-78	phosphofructokinase, liver type	Homo sapiens	79-83
9855005-5	1998	Furthermore, the mutagenic response at HPRT induced by 6-TG was substantially increased in the MMR-deficient lines relative to the MMR-proficient cell lines.	Thioguanine	55-59	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	39-43
9758206-6	1998	These results indicate that liver cell nuclei possess the necessary enzymes to incorporate the delta5 desaturase substrate (20:3 n-6) as well as the product of desaturation (20:4 n-6) into nuclear TG, DG and PL following an acyl-CoA dependent pathway.	Thioguanine	197-199	fatty acid desaturase 1	Rattus norvegicus	95-112
9914780-8	1998	in and surrounding the lesions were decreased, more prominently in GST-P-Tg rats than in N-Tg rats, the 8-OHG levels were also decreased but similarly in both cases.	Thioguanine	73-75	glutathione S-transferase pi 1	Rattus norvegicus	67-72
9780130-1	1998	Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulphydryl compounds, such as the thiopurine drugs azathioprine, mercaptopurine, and thioguanine.	Thioguanine	222-233	thiopurine S-methyltransferase	Homo sapiens	0-28
9780130-1	1998	Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulphydryl compounds, such as the thiopurine drugs azathioprine, mercaptopurine, and thioguanine.	Thioguanine	222-233	thiopurine S-methyltransferase	Homo sapiens	30-34
9707623-8	1998	Furthermore, biliary cholesterol levels in SR-BI Tg mice were strongly and inversely correlated with the percentage of dietary cholesterol absorbed (r = -0.99, P &lt; 0.0008).	Thioguanine	49-51	scavenger receptor class B, member 1	Mus musculus	43-48
9920053-1	1998	Compiling hprt mutation spectra involves the isolation and analysis of numerous 6-thioguanine-resistant clones for identifying characteristic point mutations.	Thioguanine	80-93	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	10-14
9746459-5	1998	Tg(+) rats showed exaggerated osmotic-induced increases in plasma VP, norepinephrine (NE), and epinephrine (Epi) compared with Tg(-) rats.	Thioguanine	0-2	arginine vasopressin	Rattus norvegicus	66-68
9729267-8	1998	Linear regression analysis detected a significant increase in the number of 6-TG-resistant clones in both AHH-1 tk+/- (p53+/-) and L3 (p53+/+).	Thioguanine	76-80	tumor protein p53	Homo sapiens	119-122
9729267-8	1998	Linear regression analysis detected a significant increase in the number of 6-TG-resistant clones in both AHH-1 tk+/- (p53+/-) and L3 (p53+/+).	Thioguanine	76-80	tumor protein p53	Homo sapiens	135-138
9695718-1	1998	OBJECTIVE: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of mercaptopurine, azathioprine, thioguanine and most of their nucleotide metabolites.	Thioguanine	137-148	thiopurine S-methyltransferase	Homo sapiens	11-41
9695718-1	1998	OBJECTIVE: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of mercaptopurine, azathioprine, thioguanine and most of their nucleotide metabolites.	Thioguanine	137-148	thiopurine S-methyltransferase	Homo sapiens	43-47
9563654-9	1998	Moreover, the inductive effect of hypoxia on c-jun expression was also inhibited by 6-TG, whereas the levels of c-fos mRNA and its protein were rather strongly increased.	Thioguanine	84-88	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50
9681671-0	1998	Thiopurine S-methyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate.	Thioguanine	87-100	thiopurine S-methyltransferase	Homo sapiens	0-30
9485200-5	1998	In supernatants from T cells further stimulated in vitro by Tg, IFN-gamma levels were higher in IFN-gamma R(0/0) than in wild-type mice throughout the course of the disease, whereas interleukin-10 was transiently increased prior to EAT onset in both groups of mice.	Thioguanine	60-62	interferon gamma	Mus musculus	64-73
9600338-1	1998	The hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in 6-thioguanine (TG) resistant T-lymphocytes is a useful target for the study of somatic in vivo mutagenesis, since it provides information about a broad spectrum of mutation.	Thioguanine	68-81	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	4-51
9600338-1	1998	The hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in 6-thioguanine (TG) resistant T-lymphocytes is a useful target for the study of somatic in vivo mutagenesis, since it provides information about a broad spectrum of mutation.	Thioguanine	68-81	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	53-57
9600338-1	1998	The hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in 6-thioguanine (TG) resistant T-lymphocytes is a useful target for the study of somatic in vivo mutagenesis, since it provides information about a broad spectrum of mutation.	Thioguanine	83-85	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	4-51
9600338-1	1998	The hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in 6-thioguanine (TG) resistant T-lymphocytes is a useful target for the study of somatic in vivo mutagenesis, since it provides information about a broad spectrum of mutation.	Thioguanine	83-85	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	53-57
9598152-4	1998	Mf at the hprt locus of PL was determined by limiting dilution assay using 6-thioguanine (6-TG).	Thioguanine	75-88	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	10-14
9598152-4	1998	Mf at the hprt locus of PL was determined by limiting dilution assay using 6-thioguanine (6-TG).	Thioguanine	90-94	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	10-14
9464317-3	1998	RNA from 6-thioguanine-resistant mutants was reverse-transcribed to cDNA and the hprt coding sequence was amplified and sequenced.	Thioguanine	9-22	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	81-85
9550543-3	1998	The purpose of this study was to determine the effect of selective beta1- and nonselective beta-adrenoceptor blockade on EPOC and the TG/FA cycle.	Thioguanine	134-136	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	67-72
9760818-8	1998	The decreased level of TC, TG and LDL correlated with the decreased concentration of TNF alpha.	Thioguanine	27-29	tumor necrosis factor	Homo sapiens	85-94
9626969-2	1998	Cells were treated with several concentrations of MNNG, and HPRT mutants were selected phenotypically by their growth in the presence of 6-thioguanine.	Thioguanine	137-150	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	60-64
9485033-1	1998	A role for the Mut L homologue-1 (MLH1) protein, a necessary component of DNA mismatch repair (MMR), in G2-M cell cycle checkpoint arrest after 6-thioguanine (6-TG) exposure was suggested previously.	Thioguanine	144-157	mutL homolog 1	Homo sapiens	15-32
9485033-1	1998	A role for the Mut L homologue-1 (MLH1) protein, a necessary component of DNA mismatch repair (MMR), in G2-M cell cycle checkpoint arrest after 6-thioguanine (6-TG) exposure was suggested previously.	Thioguanine	144-157	mutL homolog 1	Homo sapiens	34-38
9485033-1	1998	A role for the Mut L homologue-1 (MLH1) protein, a necessary component of DNA mismatch repair (MMR), in G2-M cell cycle checkpoint arrest after 6-thioguanine (6-TG) exposure was suggested previously.	Thioguanine	159-163	mutL homolog 1	Homo sapiens	15-32
9485033-1	1998	A role for the Mut L homologue-1 (MLH1) protein, a necessary component of DNA mismatch repair (MMR), in G2-M cell cycle checkpoint arrest after 6-thioguanine (6-TG) exposure was suggested previously.	Thioguanine	159-163	mutL homolog 1	Homo sapiens	34-38
9485033-5	1998	MMR-deficient HCT116 cells or embryonic fibroblasts from MLH1 knockout mice also demonstrated classic DNA damage tolerance responses after 6-TG exposure.	Thioguanine	139-143	mutL homolog 1	Homo sapiens	57-61
9485033-6	1998	Interestingly, an enhanced p53 protein induction response was observed in HCT116 3-6 (MLH1+) compared with HCT116 (MLH1-) cells after IR or 6-TG.	Thioguanine	140-144	transformation related protein 53, pseudogene	Mus musculus	27-30
9485033-6	1998	Interestingly, an enhanced p53 protein induction response was observed in HCT116 3-6 (MLH1+) compared with HCT116 (MLH1-) cells after IR or 6-TG.	Thioguanine	140-144	mutL homolog 1	Mus musculus	86-90
9485200-5	1998	In supernatants from T cells further stimulated in vitro by Tg, IFN-gamma levels were higher in IFN-gamma R(0/0) than in wild-type mice throughout the course of the disease, whereas interleukin-10 was transiently increased prior to EAT onset in both groups of mice.	Thioguanine	60-62	interferon gamma	Mus musculus	96-105
9399700-1	1997	In an attempt to elucidate mechanisms underlying the variation in radiosensitivity during the cell cycle, mutations in the HPRT gene were selected with 6-thioguanine, quantified and characterized in synchronous human bladder carcinoma cells (EJ30-15) that were irradiated in G1 or S phase with 3 or 6 Gy.	Thioguanine	152-165	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	123-127
9572397-10	1998	We found that the tyrosine phosphorylation level of MAP kinase is higher in dense compared to sparse cultures and, moreover, 6-thioguanine (6-TG), a potent inhibitor of ERKs, reduced VEGF mRNA levels in high but not low confluency.	Thioguanine	125-138	vascular endothelial growth factor A	Homo sapiens	183-187
9572397-10	1998	We found that the tyrosine phosphorylation level of MAP kinase is higher in dense compared to sparse cultures and, moreover, 6-thioguanine (6-TG), a potent inhibitor of ERKs, reduced VEGF mRNA levels in high but not low confluency.	Thioguanine	140-144	vascular endothelial growth factor A	Homo sapiens	183-187
9730139-8	1998	In conclusion, our results suggest that hypoalphalipoproteinemia with elevated TG level may be associated with genetic variations of the LPL gene.	Thioguanine	79-81	lipoprotein lipase	Homo sapiens	137-140
9491399-6	1998	The EMS treatments were conducted in F12 medium for 2 h. AS52 cells carry a single functional gpt gene which provides for quantitation of gpt mutants by selecting for 6-thioguanine resistance.	Thioguanine	167-180	alanine aminotransferase 1	Cricetulus griseus	94-97
9491399-6	1998	The EMS treatments were conducted in F12 medium for 2 h. AS52 cells carry a single functional gpt gene which provides for quantitation of gpt mutants by selecting for 6-thioguanine resistance.	Thioguanine	167-180	alanine aminotransferase 1	Cricetulus griseus	138-141
9413144-4	1997	A rapid loss of enzyme (lactase) activity was observed in heated sucrose systems at T &gt; Tg, and this was attributed to sucrose crystallization since it is known that upon crystallization the protective effect of sugars is lost.	Thioguanine	91-93	lactase	Homo sapiens	24-31
9395201-6	1997	Mutant frequencies at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in V79 were determined as the number of 6-thioguanine-resistant cells per 10(6) cells.	Thioguanine	126-139	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	26-72
9395201-6	1997	Mutant frequencies at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in V79 were determined as the number of 6-thioguanine-resistant cells per 10(6) cells.	Thioguanine	126-139	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	74-78
9392420-3	1997	Of the total fatty acids liberated with HDL3 only 1% are from triolein (TG), while 49% are from diolein (DG) and 50% are from PL.	Thioguanine	72-74	HDL3	Homo sapiens	40-44
9392420-4	1997	A spherical reconstituted particle containing 2 molecules of apoA-I, 120 molecules of PL, and 20 molecules of TG exhibits a total lipid hydrolytic rate of 18 nM FA/h per microM PL and 93% of the fatty acids liberated are from PL.	Thioguanine	110-112	fumarylacetoacetate hydrolase	Homo sapiens	161-165
9392420-8	1997	A particle containing 10 molecules of TG and 40 molecules DG yields the fastest lipid hydrolytic rate of 143 nM FA/h per microM PL, which constitutes 96% DG hydrolysis, 3% TG hydrolysis, and 1% PC hydrolysis.	Thioguanine	38-40	fumarylacetoacetate hydrolase	Homo sapiens	112-116
9392420-8	1997	A particle containing 10 molecules of TG and 40 molecules DG yields the fastest lipid hydrolytic rate of 143 nM FA/h per microM PL, which constitutes 96% DG hydrolysis, 3% TG hydrolysis, and 1% PC hydrolysis.	Thioguanine	172-174	fumarylacetoacetate hydrolase	Homo sapiens	112-116
9288785-7	1997	Furthermore, E7 and Ras or spontaneously immortalized Msh2-/- cells were significantly more resistant to the cytotoxic effects of 6-thioguanine relative to Msh2+/+ cells.	Thioguanine	130-143	mutS homolog 2	Mus musculus	54-58
9397190-7	1997	Point mutations at codons 12 and 61 of the murine Ki-ras gene were observed, however, in one of 10 and six of 10 lung tumors respectively, from VC-treated non-Tg mice.	Thioguanine	159-161	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	50-56
9477124-5	1997	Low-dose therapy with cytarabine and thioguanine was given between the initial courses of histamine/IL-2.	Thioguanine	37-48	interleukin 2	Homo sapiens	100-104
9329764-5	1997	Omega-3 PUFA reduce fasting and postprandial TG, may improve insulin sensitivity (as shown in animal experiments), decrease platelet and leukocyte reactivity, alter immunological functions, and may slightly decrease blood pressure.	Thioguanine	45-47	pumilio RNA binding family member 3	Homo sapiens	8-12
9330623-0	1997	Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.	Thioguanine	88-101	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	75-79
9187113-6	1997	The frequency of spontaneous HPRT gene mutations, selected by their resistance to 6-thioguanine, was 3-fold lower in Cx43+ cells than Cx43- cells.	Thioguanine	82-95	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	29-33
9291350-1	1997	Ionizing radiations induce mutations which can be detected both in coding sequences (Hprt locus) by measuring the frequency of 6-thioguanine-resistant cells and in minisatellite sequences by DNA fingerprint analysis.	Thioguanine	127-140	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	85-89
9262380-0	1997	Tissue specific toxicities of the anticancer drug 6-thioguanine is dependent on the Hprt status in transgenic mice.	Thioguanine	50-63	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	84-88
9262380-4	1997	Loss of Hprt has been associated with the resistance of leukemias to 6TG chemotherapy, however, nothing has been known about the effect of Hprt status on tissue specific toxicity of 6TG in vivo.	Thioguanine	69-72	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	8-12
9262380-7	1997	Serum biochemical analyses of 6TG-treated wild-type mice showed elevated serum enzyme levels characteristic of liver damage whereas the levels in Hprt-deficient 6TG-treated mice were within normal physiological limits.	Thioguanine	161-164	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	146-150
9268200-5	1997	Labelled thrombin studies document the rapid passage of thrombin through an intact vessel wall or vessels with an anastomosis when TG was applied to the adventitial surface of the vessel.	Thioguanine	131-133	coagulation factor II, thrombin	Homo sapiens	9-17
9268200-5	1997	Labelled thrombin studies document the rapid passage of thrombin through an intact vessel wall or vessels with an anastomosis when TG was applied to the adventitial surface of the vessel.	Thioguanine	131-133	coagulation factor II, thrombin	Homo sapiens	56-64
9233776-6	1997	Furthermore, cisplatin and doxorubicin-resistant ovarian lines deficient in hMLH1 expression are cross-resistant to 6-thioguanine and the methylating agent N-methyl-N-nitrosourea (MNU).	Thioguanine	116-129	mutL homolog 1	Homo sapiens	76-81
9177237-1	1997	TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and thioguanine.	Thioguanine	160-171	thiopurine S-methyltransferase	Homo sapiens	0-4
9187113-6	1997	The frequency of spontaneous HPRT gene mutations, selected by their resistance to 6-thioguanine, was 3-fold lower in Cx43+ cells than Cx43- cells.	Thioguanine	82-95	gap junction protein alpha 1	Homo sapiens	117-121
10684052-4	1997	The results of the linear correlation showed that there was a positive correlation of apoC II, C III, E with TG, TC, LDL-C; of apoC II, C III with BMI; and of apoE with ages.	Thioguanine	109-111	apolipoprotein C2	Homo sapiens	86-93
9103127-1	1997	BACKGROUND: Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (that is, inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic polymorphism.	Thioguanine	139-150	thiopurine S-methyltransferase	Homo sapiens	12-42
9103127-1	1997	BACKGROUND: Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (that is, inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic polymorphism.	Thioguanine	139-150	thiopurine S-methyltransferase	Homo sapiens	44-48
10684054-8	1997	The correlation analysis indicated that there was a positive correlation of apoB100 with serum TG, TC, LDL-C, apoC II, C III and E respectively (P &lt; 0.01); and a negative correlation with HDL-C levels (r = 0.1312); and apoB100 correlated negatively with apoA I (r = -0.0706).	Thioguanine	95-97	apolipoprotein B	Homo sapiens	76-83
10684054-9	1997	The results suggest that serum TG, TC, LDL-C, apoC II, C III and E are the main factors related with the serum apoB100 levels.	Thioguanine	31-33	apolipoprotein B	Homo sapiens	111-118
9027363-7	1997	The cellular uptake of polyamines in the liver from tg+ mice showed an increase and considerable changes were observed in the activity of ornithine decarboxylase (ODC) in the liver and kidney and S-adenosylmethionine decarboxylase (AdoMetDC) in the liver.	Thioguanine	52-54	ornithine decarboxylase, structural 1	Mus musculus	138-161
9015161-5	1997	Selection in thioguanine alone (TGr/gpt(-)) allows the growth of all gpt(-) mutants (small, intermediate and large deletions/insertions and point mutations) while selection in thioguanine and G418 (TGr/gpt(-), G418r/neo+) prevents survival of colonies containing vary large deletions of the gpt gene that include the neo gene.	Thioguanine	13-24	alanine aminotransferase 1	Cricetulus griseus	36-39
9015161-5	1997	Selection in thioguanine alone (TGr/gpt(-)) allows the growth of all gpt(-) mutants (small, intermediate and large deletions/insertions and point mutations) while selection in thioguanine and G418 (TGr/gpt(-), G418r/neo+) prevents survival of colonies containing vary large deletions of the gpt gene that include the neo gene.	Thioguanine	13-24	alanine aminotransferase 1	Cricetulus griseus	69-72
9015161-5	1997	Selection in thioguanine alone (TGr/gpt(-)) allows the growth of all gpt(-) mutants (small, intermediate and large deletions/insertions and point mutations) while selection in thioguanine and G418 (TGr/gpt(-), G418r/neo+) prevents survival of colonies containing vary large deletions of the gpt gene that include the neo gene.	Thioguanine	13-24	alanine aminotransferase 1	Cricetulus griseus	69-72
9015161-5	1997	Selection in thioguanine alone (TGr/gpt(-)) allows the growth of all gpt(-) mutants (small, intermediate and large deletions/insertions and point mutations) while selection in thioguanine and G418 (TGr/gpt(-), G418r/neo+) prevents survival of colonies containing vary large deletions of the gpt gene that include the neo gene.	Thioguanine	13-24	alanine aminotransferase 1	Cricetulus griseus	69-72
9015161-8	1997	The predominant type of hmdUrd induced mutation in the thioguanine resistant cells at the gpt locus was complete loss of the gpt gene resulting from a large deletion.	Thioguanine	55-66	alanine aminotransferase 1	Cricetulus griseus	90-93
9015161-8	1997	The predominant type of hmdUrd induced mutation in the thioguanine resistant cells at the gpt locus was complete loss of the gpt gene resulting from a large deletion.	Thioguanine	55-66	alanine aminotransferase 1	Cricetulus griseus	125-128
9027363-7	1997	The cellular uptake of polyamines in the liver from tg+ mice showed an increase and considerable changes were observed in the activity of ornithine decarboxylase (ODC) in the liver and kidney and S-adenosylmethionine decarboxylase (AdoMetDC) in the liver.	Thioguanine	52-54	ornithine decarboxylase, structural 1	Mus musculus	163-166
9027363-7	1997	The cellular uptake of polyamines in the liver from tg+ mice showed an increase and considerable changes were observed in the activity of ornithine decarboxylase (ODC) in the liver and kidney and S-adenosylmethionine decarboxylase (AdoMetDC) in the liver.	Thioguanine	52-54	S-adenosylmethionine decarboxylase 1	Mus musculus	196-230
9027363-7	1997	The cellular uptake of polyamines in the liver from tg+ mice showed an increase and considerable changes were observed in the activity of ornithine decarboxylase (ODC) in the liver and kidney and S-adenosylmethionine decarboxylase (AdoMetDC) in the liver.	Thioguanine	52-54	S-adenosylmethionine decarboxylase 1	Mus musculus	232-240
9049058-3	1997	Mutation induction at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus was measured by cloning the exposed T-cells in microtitre plates in the presence and absence of 6-thioguanine (TG).	Thioguanine	182-195	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	26-72
9049058-3	1997	Mutation induction at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus was measured by cloning the exposed T-cells in microtitre plates in the presence and absence of 6-thioguanine (TG).	Thioguanine	197-199	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	26-72
9049058-3	1997	Mutation induction at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus was measured by cloning the exposed T-cells in microtitre plates in the presence and absence of 6-thioguanine (TG).	Thioguanine	197-199	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	74-78
9054586-7	1997	Structural alterations at the hprt locus in independent thioguanine-resistant clones were examined by Southern blot analysis of Pst I-digested DNA with a full-length human hprt cDNA probe.	Thioguanine	56-67	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	30-34
8993938-5	1996	Thus, compared with control, pathophysiologic concentrations of insulin increased PAI-1 accumulation in conditioned media modestly, as did VLDL, but the combination elicited a marked nine-fold increase (control PAI-130 +/- 2 ng/ml, PAI-1 with 400 mg/dl VLDL-TG 97 +/- 6 ng/ml; with 4 nmol/1 insulin 45 +/- 6 ng/ml, with 400 mg/dl VLDL-TG plus 4 nmol/1 insulin 276 +/- 47 ng/ml; P &lt; 0.01 for the combination compared with control or with either agent alone).	Thioguanine	335-337	insulin	Homo sapiens	64-71
9118963-1	1997	We have monitored mutant frequency at the HPRT locus in peripheral blood lymphocytes of cynomolgus monkeys using a clonal assay in which mutants are selected by resistance to 6-thioguanine.	Thioguanine	175-188	hypoxanthine-guanine phosphoribosyltransferase	Macaca fascicularis	42-46
9199483-11	1997	In conclusion, these results indicate that the decrease in Na/Li CT associated with both dietary and drug treatment of hypertriglyceridemia is to be traced to a direct effect of plasma TG concentration on this transport system (probably as a result of modification in the membrane lipid environment) rather than to changes in plasma insulin levels or insulin resistance.	Thioguanine	185-187	insulin	Homo sapiens	333-340
9199483-11	1997	In conclusion, these results indicate that the decrease in Na/Li CT associated with both dietary and drug treatment of hypertriglyceridemia is to be traced to a direct effect of plasma TG concentration on this transport system (probably as a result of modification in the membrane lipid environment) rather than to changes in plasma insulin levels or insulin resistance.	Thioguanine	185-187	insulin	Homo sapiens	351-358
12215806-1	1997	Sequencing analysis of lipoprotein lipase (LPL) gene exons l-9 was made in 11 cases of Chinese patients with severe endogenous hypertriglyceridemia (serum TG &gt; 7.68 mmol/L) by the dideoxy chain termination method using Sequenase PCR Product Sequencing Kit.	Thioguanine	155-157	lipoprotein lipase	Homo sapiens	23-41
12215806-1	1997	Sequencing analysis of lipoprotein lipase (LPL) gene exons l-9 was made in 11 cases of Chinese patients with severe endogenous hypertriglyceridemia (serum TG &gt; 7.68 mmol/L) by the dideoxy chain termination method using Sequenase PCR Product Sequencing Kit.	Thioguanine	155-157	lipoprotein lipase	Homo sapiens	43-46
8977461-7	1996	The TG(4A)C-induced liver uptake of 125I-Lp(a) could be ascribed mainly to Kupffer cells (76 +/- 7%), whereas the parenchymal liver cell was the major site for liver uptake of TG(20A)C-laden 125I-Lp(a) (55 +/- 12%).	Thioguanine	4-6	lipoprotein(a)	Homo sapiens	41-46
8977461-7	1996	The TG(4A)C-induced liver uptake of 125I-Lp(a) could be ascribed mainly to Kupffer cells (76 +/- 7%), whereas the parenchymal liver cell was the major site for liver uptake of TG(20A)C-laden 125I-Lp(a) (55 +/- 12%).	Thioguanine	4-6	lipoprotein(a)	Homo sapiens	196-201
8993938-5	1996	Thus, compared with control, pathophysiologic concentrations of insulin increased PAI-1 accumulation in conditioned media modestly, as did VLDL, but the combination elicited a marked nine-fold increase (control PAI-130 +/- 2 ng/ml, PAI-1 with 400 mg/dl VLDL-TG 97 +/- 6 ng/ml; with 4 nmol/1 insulin 45 +/- 6 ng/ml, with 400 mg/dl VLDL-TG plus 4 nmol/1 insulin 276 +/- 47 ng/ml; P &lt; 0.01 for the combination compared with control or with either agent alone).	Thioguanine	258-260	insulin	Homo sapiens	64-71
9435883-4	1997	By PCR deletion screening, about 20% of recovered spontaneous 6-thioguanine resistant (6TG) gpt G12 mutants had deleted the transgene, whereas the deletion mutant frequency was increased to about 50% of the X-ray- and bleomycin-induced G12 mutants.	Thioguanine	62-75	alanine aminotransferase 1	Cricetulus griseus	92-95
8954101-1	1996	6-Thioguanine (thioG) was chemically incorporated into 25-base oligodeoxynucleotides encoding the c-fos serum response element (SRE) at positions corresponding to each guanine of the CArG box, which only slightly impaired DNA binding by the Serum Response Factor (SRF).	Thioguanine	0-13	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
8954101-1	1996	6-Thioguanine (thioG) was chemically incorporated into 25-base oligodeoxynucleotides encoding the c-fos serum response element (SRE) at positions corresponding to each guanine of the CArG box, which only slightly impaired DNA binding by the Serum Response Factor (SRF).	Thioguanine	0-13	serum response factor	Homo sapiens	241-262
8954101-1	1996	6-Thioguanine (thioG) was chemically incorporated into 25-base oligodeoxynucleotides encoding the c-fos serum response element (SRE) at positions corresponding to each guanine of the CArG box, which only slightly impaired DNA binding by the Serum Response Factor (SRF).	Thioguanine	0-13	serum response factor	Homo sapiens	264-267
8954101-1	1996	6-Thioguanine (thioG) was chemically incorporated into 25-base oligodeoxynucleotides encoding the c-fos serum response element (SRE) at positions corresponding to each guanine of the CArG box, which only slightly impaired DNA binding by the Serum Response Factor (SRF).	Thioguanine	15-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
8954101-1	1996	6-Thioguanine (thioG) was chemically incorporated into 25-base oligodeoxynucleotides encoding the c-fos serum response element (SRE) at positions corresponding to each guanine of the CArG box, which only slightly impaired DNA binding by the Serum Response Factor (SRF).	Thioguanine	15-20	serum response factor	Homo sapiens	241-262
8954101-1	1996	6-Thioguanine (thioG) was chemically incorporated into 25-base oligodeoxynucleotides encoding the c-fos serum response element (SRE) at positions corresponding to each guanine of the CArG box, which only slightly impaired DNA binding by the Serum Response Factor (SRF).	Thioguanine	15-20	serum response factor	Homo sapiens	264-267
8954101-2	1996	Upon exposure to long wavelength UV light each thioG-containing SRE could be crosslinked to SRF, with efficiencies ranging from &lt; 1 to 25% of the complex depending on the position of thioG in the SRE and on the UV source used.	Thioguanine	47-52	serum response factor	Homo sapiens	92-95
8954101-2	1996	Upon exposure to long wavelength UV light each thioG-containing SRE could be crosslinked to SRF, with efficiencies ranging from &lt; 1 to 25% of the complex depending on the position of thioG in the SRE and on the UV source used.	Thioguanine	186-191	serum response factor	Homo sapiens	92-95
8902152-6	1996	The rate limiting factor for CETP-mediated transfer of HDL-derived cholesteryl ester (CE) was the plasma triglyceride concentration, that is, the content of triglycerides per lipoprotein particle and the quantity of TG-containing particles (VLDL + LDL).	Thioguanine	216-218	cholesteryl ester transfer protein	Homo sapiens	29-33
8879439-9	1996	Taken together, these results suggest that treatment with gemfibrozil reduces plasma concentrations of VLDL and alters the apoprotein composition of VLDL in a manner that may favor LDL- and VLDL-receptor-mediated clearance of the apoE-rich VLDL subfraction, thereby reducing TG-rich particle concentrations, and possibly reducing risk for coronary heart disease.	Thioguanine	275-277	very low density lipoprotein receptor	Homo sapiens	190-203
8876696-3	1996	Point mutational hotspots were observed in bp 215 to 318 of the third exon of the hprt gene after mutants were selected en masse with 6-thioguanine, using a combination of denaturing gradient gel electrophoresis and high fidelity polymerase chain reaction.	Thioguanine	134-147	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	82-86
8933281-2	1996	In order to characterize the TPO-reactive idiotype, we selected a TG monoclonal antibody (mAb J7 B49.15) which bound to TPO and cross-reacted with human bispecific TG and TPO autoantibodies (TGPO aAb) for both TG and TPO binding.	Thioguanine	66-68	thyroid peroxidase	Homo sapiens	29-32
8933281-2	1996	In order to characterize the TPO-reactive idiotype, we selected a TG monoclonal antibody (mAb J7 B49.15) which bound to TPO and cross-reacted with human bispecific TG and TPO autoantibodies (TGPO aAb) for both TG and TPO binding.	Thioguanine	66-68	thyroid peroxidase	Homo sapiens	120-123
8933281-2	1996	In order to characterize the TPO-reactive idiotype, we selected a TG monoclonal antibody (mAb J7 B49.15) which bound to TPO and cross-reacted with human bispecific TG and TPO autoantibodies (TGPO aAb) for both TG and TPO binding.	Thioguanine	66-68	thyroid peroxidase	Homo sapiens	164-174
8933281-2	1996	In order to characterize the TPO-reactive idiotype, we selected a TG monoclonal antibody (mAb J7 B49.15) which bound to TPO and cross-reacted with human bispecific TG and TPO autoantibodies (TGPO aAb) for both TG and TPO binding.	Thioguanine	66-68	thyroid peroxidase	Homo sapiens	120-123
8879439-9	1996	Taken together, these results suggest that treatment with gemfibrozil reduces plasma concentrations of VLDL and alters the apoprotein composition of VLDL in a manner that may favor LDL- and VLDL-receptor-mediated clearance of the apoE-rich VLDL subfraction, thereby reducing TG-rich particle concentrations, and possibly reducing risk for coronary heart disease.	Thioguanine	275-277	apolipoprotein E	Homo sapiens	230-234
9387400-6	1996	Our data suggest that the polymorphisms at the LPL gene, as the linkage markers with an aetiologic mutation at or around LPL gene, may constitute one of the genetic determinants for the population variation in plasma TG levels, as well as for the common dyslipidemia in Chinese populations.	Thioguanine	217-219	lipoprotein lipase	Homo sapiens	47-50
9387400-6	1996	Our data suggest that the polymorphisms at the LPL gene, as the linkage markers with an aetiologic mutation at or around LPL gene, may constitute one of the genetic determinants for the population variation in plasma TG levels, as well as for the common dyslipidemia in Chinese populations.	Thioguanine	217-219	lipoprotein lipase	Homo sapiens	121-124
9000176-1	1996	Human hepatoma cells deficient in HPRT activity were isolated by challenging HepG2 cells with 6-thioguanine (6TG).	Thioguanine	94-107	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	34-38
8857546-0	1996	Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism.	Thioguanine	50-63	thiopurine S-methyltransferase	Homo sapiens	79-107
8857546-5	1996	When low TGNs are due to very high TPMT activities, thioguanine may be a more appropriate thiopurine.	Thioguanine	52-63	thiopurine S-methyltransferase	Homo sapiens	35-39
8691031-1	1996	Mutation induction by accelerated heavy ions to 6-TG resistance (HPRT system) in V79 Chinese hamster cells was investigated with Ni (6-630 Me V/u), Au (2.2, 8.7 Me V/u) and Pb ions (11.6-980 Me V/u) corresponding to a LET range between 180 and 12895 ke V/microns.	Thioguanine	48-52	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	65-69
8873214-1	1996	Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as mercaptopurine and thioguanine.	Thioguanine	108-119	thiopurine S-methyltransferase	Homo sapiens	0-30
8873214-1	1996	Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as mercaptopurine and thioguanine.	Thioguanine	108-119	thiopurine S-methyltransferase	Homo sapiens	32-36
8991079-4	1996	The gpt mutants can be positively detected as colonies arising on plates containing chloramphenicol and 6-thioguanine.	Thioguanine	104-117	glutamic pyruvic transaminase, soluble	Mus musculus	4-7
8625293-5	1996	In the absence of DNA damage, there was a significant increase (2-3-fold) in the number of 6-TG-resistant colonies derived from p21 -/- versus +/+ cells.	Thioguanine	93-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	128-131
8928922-6	1996	PVN injection of AT1 receptor antisense oligodeoxynucleotides (ASODN), but not scrambled oligodeoxynucleotides (SCODN), produced a rapid decrease in MAP of 24 +/_ 8 mmHg in salt-treated Tg(+) rats.	Thioguanine	186-188	angiotensin II receptor, type 1a	Rattus norvegicus	17-20
8725879-0	1996	Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine.	Thioguanine	86-99	glutamic--pyruvic transaminase	Rattus norvegicus	17-20
8797053-5	1996	Further studies may be necessary to determine if hypertriglyceridemic patients with or without apolipoprotein E4 show a greater reduction in serum TG levels with lipid-lowering agents.	Thioguanine	147-149	apolipoprotein E	Homo sapiens	95-112
8644731-1	1996	The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is associated with severe hematopoietic toxicity when patients are treated with standard doses of mercaptopurine, azathioprine, or thioguanine.	Thioguanine	212-223	thiopurine S-methyltransferase	Homo sapiens	33-62
8644731-1	1996	The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is associated with severe hematopoietic toxicity when patients are treated with standard doses of mercaptopurine, azathioprine, or thioguanine.	Thioguanine	212-223	thiopurine S-methyltransferase	Homo sapiens	64-68
8596500-9	1996	Results of the present study indicate that PH-LPL activity is related to plasma triglyceride, VLDL-TG, VLDL-C, VLDL-apo B, apo B, and HDL-C levels and the HDL-C to cholesterol ratio in men carrying the apo E2 isoform, but not in men homozygous for the apo E3 isoform or among apo E4 carriers.	Thioguanine	99-101	lipoprotein lipase	Homo sapiens	46-49
8844990-0	1996	5-Azacytidine-induced 6-thioguanine resistance at the gpt locus in AS52 cells: cellular response.	Thioguanine	22-35	alanine aminotransferase 1	Cricetulus griseus	54-57
7490018-4	1995	The result of multiple factor analysis showed that apoC III, E, B100/A I, VLDL apoC III and HDL apo C II, E, C II/C III, among 20 factors, were main factors which were related with TG.	Thioguanine	181-183	apolipoprotein C3	Homo sapiens	51-59
7592936-4	1995	Inclusion of eight molecules of TG into the complex significantly reduces the alpha-helix content and stability of apoA-I, whereas inclusion of four molecules of CE into the complex has an opposite effect in that the alpha-helix content is significantly reduced and the stability of the remaining alpha-helical structure of apoA-I is increased.	Thioguanine	32-34	apolipoprotein A1	Homo sapiens	115-121
7592936-7	1995	Inclusion of either 10 molecules of TG or six molecules of CE into such a particle increases both the alpha-helix content and stability of apoA-I.	Thioguanine	36-38	apolipoprotein A1	Homo sapiens	139-145
7592936-11	1995	Such dissociation of apoA-I molecules from LpA-I particles that have a low CE/TG ratio would be promoted in the hypertriglyceridemic state in vivo.	Thioguanine	78-80	apolipoprotein A1	Homo sapiens	21-27
8568921-12	1995	Effects of staurosporine, 6-TG, and sphingosine on c-fos gene induction with or without NGF were not correlated with the generation of neurites.	Thioguanine	26-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
8563768-1	1995	Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including thiopurine antimetabolites (i.e. mercaptopurine and thioguanine).	Thioguanine	179-190	thiopurine S-methyltransferase	Homo sapiens	0-30
8563768-1	1995	Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including thiopurine antimetabolites (i.e. mercaptopurine and thioguanine).	Thioguanine	179-190	thiopurine S-methyltransferase	Homo sapiens	32-36
8722744-10	1996	When the segregation models allowed apo E regression coefficients to be ousiotype (class) specific, the results suggested that apo E genotypes have a significant effect on LDL-C, TG, and Lp(a) levels.	Thioguanine	179-181	apolipoprotein E	Homo sapiens	127-132
7577474-4	1995	To circumvent the problem, HPRT- [6-thioguanine (6-TG)-resistant] clones were isolated by inactivating all hprt genes with methylnitrosourea.	Thioguanine	33-47	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	27-31
7577474-4	1995	To circumvent the problem, HPRT- [6-thioguanine (6-TG)-resistant] clones were isolated by inactivating all hprt genes with methylnitrosourea.	Thioguanine	33-47	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	107-111
7577474-4	1995	To circumvent the problem, HPRT- [6-thioguanine (6-TG)-resistant] clones were isolated by inactivating all hprt genes with methylnitrosourea.	Thioguanine	49-53	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	27-31
7577474-4	1995	To circumvent the problem, HPRT- [6-thioguanine (6-TG)-resistant] clones were isolated by inactivating all hprt genes with methylnitrosourea.	Thioguanine	49-53	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	107-111
7577474-9	1995	The frequency of mutations arising in vivo in the marker hprt gene could be estimated by culturing explanted tumour cells in the presence of 6-TG, using G418 selection to distinguish tumour from host cells.	Thioguanine	141-145	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	57-61
8568921-1	1995	The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG).	Thioguanine	331-344	nerve growth factor	Rattus norvegicus	77-80
8568921-1	1995	The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG).	Thioguanine	331-344	nerve growth factor	Rattus norvegicus	96-99
8568921-1	1995	The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG).	Thioguanine	346-350	nerve growth factor	Rattus norvegicus	77-80
8568921-1	1995	The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG).	Thioguanine	346-350	nerve growth factor	Rattus norvegicus	96-99
8568921-3	1995	Both sphingosine and 6-TG inhibited neurite outgrowth induced by staurosporine and basic fibroblast derived growth factor (bFGF), as well as by NGF; therefore, sphingosine- and 6-TG-sensitive protein kinase steps occur after the convergence of the NGF, bFGF, and staurosporine signal pathways.	Thioguanine	21-25	fibroblast growth factor 2	Rattus norvegicus	83-121
8568921-3	1995	Both sphingosine and 6-TG inhibited neurite outgrowth induced by staurosporine and basic fibroblast derived growth factor (bFGF), as well as by NGF; therefore, sphingosine- and 6-TG-sensitive protein kinase steps occur after the convergence of the NGF, bFGF, and staurosporine signal pathways.	Thioguanine	21-25	fibroblast growth factor 2	Rattus norvegicus	123-127
8568921-3	1995	Both sphingosine and 6-TG inhibited neurite outgrowth induced by staurosporine and basic fibroblast derived growth factor (bFGF), as well as by NGF; therefore, sphingosine- and 6-TG-sensitive protein kinase steps occur after the convergence of the NGF, bFGF, and staurosporine signal pathways.	Thioguanine	21-25	nerve growth factor	Rattus norvegicus	144-147
8568921-3	1995	Both sphingosine and 6-TG inhibited neurite outgrowth induced by staurosporine and basic fibroblast derived growth factor (bFGF), as well as by NGF; therefore, sphingosine- and 6-TG-sensitive protein kinase steps occur after the convergence of the NGF, bFGF, and staurosporine signal pathways.	Thioguanine	21-25	nerve growth factor	Rattus norvegicus	248-251
8568921-3	1995	Both sphingosine and 6-TG inhibited neurite outgrowth induced by staurosporine and basic fibroblast derived growth factor (bFGF), as well as by NGF; therefore, sphingosine- and 6-TG-sensitive protein kinase steps occur after the convergence of the NGF, bFGF, and staurosporine signal pathways.	Thioguanine	21-25	fibroblast growth factor 2	Rattus norvegicus	253-257
7477056-1	1995	The T-cell-cloning assay was established to determine the frequency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutant lymphocytes in the presence of the selective agent 6-thioguanine in peripheral blood from a human control population.	Thioguanine	183-196	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	71-117
7477056-1	1995	The T-cell-cloning assay was established to determine the frequency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutant lymphocytes in the presence of the selective agent 6-thioguanine in peripheral blood from a human control population.	Thioguanine	183-196	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	119-123
7548306-9	1995	In this group, there was a positive and significant association between basal insulin and DBP (r = 0.67; p &lt; 0.01), and between DBP and both TG (r = 0.74; p &lt; 0.01)) and VLDL-C (r = 0.58; p &lt; 0.05).	Thioguanine	144-146	D-box binding PAR bZIP transcription factor	Homo sapiens	131-134
7490018-4	1995	The result of multiple factor analysis showed that apoC III, E, B100/A I, VLDL apoC III and HDL apo C II, E, C II/C III, among 20 factors, were main factors which were related with TG.	Thioguanine	181-183	apolipoprotein C3	Homo sapiens	79-87
7490018-5	1995	Apo C III, VLDL apoC III and LDL apoB100 were main factors which affected VLDL TG.	Thioguanine	79-81	apolipoprotein B	Homo sapiens	33-40
7753096-9	1995	We arrive at an estimate of mutation rate to 6-thioguanine resistance at the hprt locus of about 5 x 10(-7) mutation events per nominal cell division.	Thioguanine	45-58	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	77-81
7603453-1	1995	Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism, catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-methylated nucleobases that are inactive, whereas S-methylated nucleotides of these thiopurines are cytotoxic.	Thioguanine	145-156	thiopurine S-methyltransferase	Homo sapiens	0-30
7603453-1	1995	Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism, catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-methylated nucleobases that are inactive, whereas S-methylated nucleotides of these thiopurines are cytotoxic.	Thioguanine	145-156	thiopurine S-methyltransferase	Homo sapiens	32-36
7603453-1	1995	Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism, catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-methylated nucleobases that are inactive, whereas S-methylated nucleotides of these thiopurines are cytotoxic.	Thioguanine	158-160	thiopurine S-methyltransferase	Homo sapiens	0-30
7603453-1	1995	Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism, catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-methylated nucleobases that are inactive, whereas S-methylated nucleotides of these thiopurines are cytotoxic.	Thioguanine	158-160	thiopurine S-methyltransferase	Homo sapiens	32-36
7603453-2	1995	A yeast-based heterologous expression system was therefore used to characterize human TPMT-catalyzed methylation of MP, TG, and their principal nucleotide metabolites [thioinosine monophosphate (TIMP) and thioguanosine monophosphate (TGMP), respectively].	Thioguanine	120-122	thiopurine S-methyltransferase	Homo sapiens	86-90
7603453-3	1995	MP, TG, TIMP, and TGMP were all substrates for human TPMT, exhibiting similar Michaelis-Menten kinetic parameters (Km, 10.6-27.1 microM; Vmax, 31-59 nmol/min/mg of TPMT).	Thioguanine	4-6	thiopurine S-methyltransferase	Homo sapiens	53-57
7603453-6	1995	These data establish that MP, TG, and their principal nucleotide metabolites are comparable substrates for polymorphic TPMT, and they demonstrate significant differences in the accumulation of active TGN and methylated nucleotides when leukemia cells are treated with MP versus TG.	Thioguanine	30-32	thiopurine S-methyltransferase	Homo sapiens	119-123
7603453-0	1995	Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.	Thioguanine	31-42	thiopurine S-methyltransferase	Homo sapiens	111-141
7628303-2	1995	The structures of adducts formed from in vitro incubation of a drug (tolmetin) glucuronide (TG) and human serum albumin (HSA), and the preferred binding sites on this protein were determined by mass spectrometry.	Thioguanine	92-94	albumin	Homo sapiens	106-119
7537850-2	1995	Many nickel-induced 6-thioguanine-resistant variants spontaneously reverted to actively express gpt, as indicated by both reversion assays and direct enzyme measurements.	Thioguanine	20-33	glutamic--pyruvic transaminase	Homo sapiens	96-99
7537850-4	1995	This was confirmed by demonstrations of increased DNA methylation, as well as by evidence indicating condensed chromatin and heterochromatinization of the gpt integration site in 6-thioguanine-resistant cells.	Thioguanine	179-192	glutamic--pyruvic transaminase	Homo sapiens	155-158
8565710-4	1995	The largest difference between the two groups was observed in HDL2 Cholesterol with a mean of 0.37 mmol/L in patients with CAD as compared with 0.49 mmol/L in normal subjects (P &lt; 0.001) and in TG (1.85 mmol/L vs 1.16 mmol/L) as well.	Thioguanine	197-199	junctophilin 3	Homo sapiens	62-66
7697817-2	1995	Recently, we found an elevated frequency of 6-thioguanine-resistant (TGr) mutations at the hyoxanthine-guanine phosphoribosyltransferase (hprt) gene in T cells of peripheral blood from atomic bomb survivors and a slight, but significant, positive correlation between the frequency of mutation and radiation dose.	Thioguanine	44-57	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	91-136
7697817-2	1995	Recently, we found an elevated frequency of 6-thioguanine-resistant (TGr) mutations at the hyoxanthine-guanine phosphoribosyltransferase (hprt) gene in T cells of peripheral blood from atomic bomb survivors and a slight, but significant, positive correlation between the frequency of mutation and radiation dose.	Thioguanine	44-57	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	138-142
7875043-3	1994	In contrast, high concentrations (33-50% each) of combined goat and mouse sera were required to reduce nonspecific binding and to improve the detection of the F4/80 antigen on PM phi elicited by thioglycollate broth (TG) or activated by maleic anhydride divinyl ether copolymer (MVE-2).	Thioguanine	217-219	adhesion G protein-coupled receptor E1	Mus musculus	159-164
8575415-1	1995	The rat lymphocyte hprt assay measures in vivo mutagenicity by quantifying the frequency of 6-thioguanine-resistant (TGr) spleen lymphocytes cultured in vitro.	Thioguanine	92-105	hypoxanthine phosphoribosyltransferase 1	Rattus norvegicus	19-23
7709602-13	1995	TTF-1 is implicated as a critical autoregulatory component in both positive and negative regulation of the TSHR and appears to be the link between TSH, the TSHR, TSHR-mediated signals, TG and TPO biosynthesis, and thyroid hormone formation.	Thioguanine	185-187	transcription termination factor 1	Homo sapiens	0-5
7700275-1	1995	The 6-thioguanine resistance (TGr) assay in human T-lymphocytes, which detects mutations at the hprt locus, identifies exposures to environmental mutagens.	Thioguanine	4-17	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	96-100
7828367-1	1995	Patients with systemic lupus erythematosus (SLE) have increased percentages of activated T cells and increased numbers of cells with mutations in their hypoxanthineguanine phosphoribosyltransferase (hprt) gene, as judged by growth in the presence of 6-thioguanine.	Thioguanine	250-263	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	152-197
7828367-1	1995	Patients with systemic lupus erythematosus (SLE) have increased percentages of activated T cells and increased numbers of cells with mutations in their hypoxanthineguanine phosphoribosyltransferase (hprt) gene, as judged by growth in the presence of 6-thioguanine.	Thioguanine	250-263	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	199-203
7698112-1	1995	The T-cell cloning assay which combines mitogen- and growth factor-dependent expansion of lymphocyte clones with thioguanine selection of hypoxanthine-guanine phosphoribosyl transferase (hprt)-negative cells has been extensively used for studying human somatic gene mutation in vivo.	Thioguanine	113-124	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	138-185
7698112-1	1995	The T-cell cloning assay which combines mitogen- and growth factor-dependent expansion of lymphocyte clones with thioguanine selection of hypoxanthine-guanine phosphoribosyl transferase (hprt)-negative cells has been extensively used for studying human somatic gene mutation in vivo.	Thioguanine	113-124	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	187-191
7837784-5	1995	RESULTS: Biochemically, ODC activity was still induced 3 and 6 months after total gastrectomy (TG), while it did not change significantly even after 9 months of feeding a Cbl-D diet.	Thioguanine	95-97	ornithine decarboxylase 1	Rattus norvegicus	24-27
7837784-12	1995	CONCLUSIONS: These results suggest: (a) ODC induction is a persistent and inherent feature in the TG-induced SCD of rat SC; (b) an increase in glial fibrillary acidic protein positive astrocytes in rat SC is not mandatorily connected with an increase in polyamine biosynthesis; (c) a mere deficiency of Cbl seems to be not the only key-point in the pathogenesis of the ODC induction and of the SCD-like lesions, both brought about in rat SC by TG.	Thioguanine	98-100	ornithine decarboxylase 1	Rattus norvegicus	40-43
8001247-3	1994	Human CYP2A6, which is known to activate NNK to a mutagen, was lipofected via a retroviral vector into the Chinese hamster ovary AS52 cell line, which contains the bacterial gpt gene and can be mutated to 6-thioguanine resistance.	Thioguanine	205-218	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	6-12
7802704-1	1994	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	120-133	thiopurine S-methyltransferase	Homo sapiens	0-28
7705766-9	1994	The positive correlation of HDL-cholesterol to E2 suggests that estrogens play a major role in lipid metabolism also in males, in spite of their low concentrations; more complex to be explained is the finding of an inverse relationship between Tg and SHBG.	Thioguanine	244-246	sex hormone binding globulin	Homo sapiens	251-255
7802704-1	1994	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	120-133	thiopurine S-methyltransferase	Homo sapiens	30-34
7802704-1	1994	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	135-139	thiopurine S-methyltransferase	Homo sapiens	0-28
7802704-1	1994	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).	Thioguanine	135-139	thiopurine S-methyltransferase	Homo sapiens	30-34
7920025-7	1994	We found that the frequency of 6-thioguanine-resistant hprt-negative T cells was significantly increased among MCTD patients (mean 566/10(6); range 122-2,845/10(6)) versus age- and sex-matched controls (mean 42/10(6); range 21-78/10(6); p &lt; 0.003).	Thioguanine	31-44	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	55-59
7866549-2	1994	TPMT S-methylates the antileukaemic drugs 6-mercaptopurine (6-MP) and 6-thioguanine and enzyme activity is inherited as a genetic trait.	Thioguanine	70-83	thiopurine S-methyltransferase	Homo sapiens	0-4
8033107-4	1994	The induction frequency of 6-thioguanine-resistant cells was significantly declined in AGT cells.	Thioguanine	27-40	angiotensinogen	Homo sapiens	87-90
7526167-2	1994	Presumptive hprt- mutants were isolated by clonal growth in the presence of 6-thioguanine.	Thioguanine	76-89	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	12-16
7526167-3	1994	DNA from 6-thioguanine-resistant colonies was amplified by the polymerase chain reaction using intronic primers flanking hprt exon 8.	Thioguanine	9-22	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	121-125
7923170-1	1994	The thiopurines 6-thioguanine (6TG) and 6-mercaptopurine (6MP) are cytotoxic to proliferating cells by a mechanism involving incorporation into DNA via the purine salvage pathway, and resistance to these agents can be conferred by lack of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase.	Thioguanine	16-29	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	266-312
7923170-1	1994	The thiopurines 6-thioguanine (6TG) and 6-mercaptopurine (6MP) are cytotoxic to proliferating cells by a mechanism involving incorporation into DNA via the purine salvage pathway, and resistance to these agents can be conferred by lack of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase.	Thioguanine	31-34	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	266-312
7923765-0	1994	Tiglylglycine excreted in urine in disorders of isoleucine metabolism and the respiratory chain measured by stable isotope dilution GC-MS. Tiglyglycine (TG), an intermediate product of the catabolism of isoleucine, is increased in the urine of patients with beta-ketothiolase deficiency or with disorders of propionate metabolism.	Thioguanine	153-155	acetyl-CoA acyltransferase 1	Homo sapiens	258-275
7520989-1	1994	A cloning assay with high cloning efficiency has been developed to detect spontaneous and induced 6-thioguanine-resistant T-lymphocytes (HPRT mutants) from the spleen of adult mice.	Thioguanine	98-111	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	137-141
7939219-4	1994	The fate of LPL-derived lypolysis products differs between tissues: for instance, in adipose tissue, LPL-mediated delivery of free fatty acids is rate-limiting for TG storage, whereas in muscle it provides an alternate source of lipid fuel.	Thioguanine	164-166	lipoprotein lipase	Homo sapiens	12-15
8091304-3	1994	SOD-Tg mice had higher maximal binding capacity (Bmax) in the shell division of the nucleus accumbens (NAc-shell) in comparison to Non-Tg littermates.	Thioguanine	4-6	NLR family, pyrin domain containing 1A	Mus musculus	103-106
8023844-5	1994	The generation of DRB1*08042 (Val-86) from DRB1*0802 (Gly-86) in the Cayapa, by a different mechanism than the (GT--&gt;TG) change in the creation of DRB1*08041 (Val-86) from DRB1*0802 in Africa, implicates selection in the convergent evolution of position 86 DR beta variants.	Thioguanine	120-122	major histocompatibility complex, class II, DR beta 1	Homo sapiens	18-22
8023844-5	1994	The generation of DRB1*08042 (Val-86) from DRB1*0802 (Gly-86) in the Cayapa, by a different mechanism than the (GT--&gt;TG) change in the creation of DRB1*08041 (Val-86) from DRB1*0802 in Africa, implicates selection in the convergent evolution of position 86 DR beta variants.	Thioguanine	120-122	major histocompatibility complex, class II, DR beta 1	Homo sapiens	43-47
8023844-5	1994	The generation of DRB1*08042 (Val-86) from DRB1*0802 (Gly-86) in the Cayapa, by a different mechanism than the (GT--&gt;TG) change in the creation of DRB1*08041 (Val-86) from DRB1*0802 in Africa, implicates selection in the convergent evolution of position 86 DR beta variants.	Thioguanine	120-122	major histocompatibility complex, class II, DR beta 1	Homo sapiens	43-47
8023844-5	1994	The generation of DRB1*08042 (Val-86) from DRB1*0802 (Gly-86) in the Cayapa, by a different mechanism than the (GT--&gt;TG) change in the creation of DRB1*08041 (Val-86) from DRB1*0802 in Africa, implicates selection in the convergent evolution of position 86 DR beta variants.	Thioguanine	120-122	major histocompatibility complex, class II, DR beta 1	Homo sapiens	43-47
7516487-0	1994	Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations.	Thioguanine	55-68	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	4-8
7516487-0	1994	Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations.	Thioguanine	55-68	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	34-38
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Thioguanine	73-76	N-acylsphingosine amidohydrolase 1	Homo sapiens	62-65
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Thioguanine	73-76	N-acylsphingosine amidohydrolase 1	Homo sapiens	94-97
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Thioguanine	73-76	endothelin receptor type A	Homo sapiens	204-207
8185629-2	1994	Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively.	Thioguanine	73-76	endothelin receptor type B	Homo sapiens	212-215
7939219-4	1994	The fate of LPL-derived lypolysis products differs between tissues: for instance, in adipose tissue, LPL-mediated delivery of free fatty acids is rate-limiting for TG storage, whereas in muscle it provides an alternate source of lipid fuel.	Thioguanine	164-166	lipoprotein lipase	Homo sapiens	101-104
20692916-2	1994	Genetic endpoints measured were: mutation to 6-thioguanine resistance at the hgprt gene locus and induction of sister chromatid exchange (SCE).	Thioguanine	45-58	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	77-82
8060379-6	1994	Bezafibrate did not affect the plasma level of HDL2-TC but reduced the HDL2-TG concentration significantly (P &lt; 0.001).	Thioguanine	76-78	junctophilin 3	Homo sapiens	71-75
8060379-7	1994	Bezafibrate increased the plasma level of HDL3-TC by 37% and reduced the HDL3-TG level significantly by 20% (P &lt; 0.001).	Thioguanine	78-80	HDL3	Homo sapiens	73-77
7902402-1	1993	Thioguanine resistant CHO cells (HPRT-) were stably cotransfected with pSV2-gpt and pi H3-CD2 vectors using the calcium phosphate coprecipitation technique.	Thioguanine	0-11	T-cell surface antigen CD2	Cricetulus griseus	90-93
8129782-3	1994	An estimate of such mutations may be obtained by focusing on mutations in the hprt gene, which can be screened by assessing relative growth of T cell clones in the presence and absence of 6-thioguanine.	Thioguanine	188-201	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	78-82
8125082-13	1994	Preliminary analysis with the single strand conformational polymorphism (SSCP) procedure following 6-thioguanine (TG) selection, also confirmed the occurrence of Exon 3 mutants of the HPRT gene in cells exposed to morphine plus EMS.	Thioguanine	99-112	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	184-188
8125082-13	1994	Preliminary analysis with the single strand conformational polymorphism (SSCP) procedure following 6-thioguanine (TG) selection, also confirmed the occurrence of Exon 3 mutants of the HPRT gene in cells exposed to morphine plus EMS.	Thioguanine	114-116	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	184-188
7514921-7	1994	TG+Zn mice had higher plasma IGF-I (p &lt; 0.05) and hepatic IGF-I mRNA (p &lt; 0.05) levels as compared to TG-Zn, C+Zn and C-Zn mice.	Thioguanine	0-2	insulin-like growth factor 1	Mus musculus	29-34
7514921-7	1994	TG+Zn mice had higher plasma IGF-I (p &lt; 0.05) and hepatic IGF-I mRNA (p &lt; 0.05) levels as compared to TG-Zn, C+Zn and C-Zn mice.	Thioguanine	0-2	insulin-like growth factor 1	Mus musculus	61-66
7514921-8	1994	Plasma IGF-I and hepatic IGF-I mRNA levels in TG-Zn mice were not different from C+Zn and C-Zn mice.	Thioguanine	46-48	insulin-like growth factor 1	Mus musculus	25-30
7514921-10	1994	Plasma BP-3 and hepatic BP-3 mRNA levels in TG+Zn mice were increased (p &lt; 0.05) as compared to TG-Zn, C-Zn and C+Zn.	Thioguanine	44-46	bone marrow stromal cell antigen 1	Mus musculus	7-28
8309581-2	1994	The ability to assess the frequency of T cells that survive in vitro in the presence of 6-thioguanine is an index of mutation at the HPRT gene locus.	Thioguanine	88-101	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	133-137
8395000-1	1993	Using an in vitro binding-site selection assay, we have demonstrated that c-Myc-Max complexes bind not only to canonical CACGTG or CATGTG motifs that are flanked by variable sequences but also to noncanonical sites that consist of an internal CG or TG dinucleotide in the context of particular variations in the CA--TG consensus.	Thioguanine	125-127	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
7689157-1	1993	The mutant frequency of 6-thioguanine resistance (HPRT locus) in circulating T lymphocytes from 23 Fanconi anemia (FA) patients has been determined.	Thioguanine	24-37	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	50-54
8395000-1	1993	Using an in vitro binding-site selection assay, we have demonstrated that c-Myc-Max complexes bind not only to canonical CACGTG or CATGTG motifs that are flanked by variable sequences but also to noncanonical sites that consist of an internal CG or TG dinucleotide in the context of particular variations in the CA--TG consensus.	Thioguanine	133-135	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
8343498-5	1993	Postheparin LPL activities were significantly lower in the low-HDL and low-HDL/high-TG groups (mean +/- SD, 9.9 +/- 2.9 and 10.4 +/- 3.0 mmol/h per liter, respectively; P &lt; .001 for both) compared with the normal-HDL group (12.5 +/- 3.7 mmol/h per liter).	Thioguanine	84-86	lipoprotein lipase	Homo sapiens	12-15
8234481-4	1993	The average frequency of spontaneous mutation at the hprt locus for control and denV-transfected cells was 3 and 15 6-thioguanine (6-TG)-resistant colonies per 10(6) surviving cells, respectively; there was no statistically significant difference between control and denV-transfected cells.	Thioguanine	116-129	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	53-57
8234481-4	1993	The average frequency of spontaneous mutation at the hprt locus for control and denV-transfected cells was 3 and 15 6-thioguanine (6-TG)-resistant colonies per 10(6) surviving cells, respectively; there was no statistically significant difference between control and denV-transfected cells.	Thioguanine	131-135	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	53-57
8234481-6	1993	After exposure to a fluence of 75 J/m2, the average frequency of UVR-induced mutation at the hprt locus was 166 mutant colonies per 10(6) surviving cells for control cells and 92 mutant colonies for denV-transfected cells; after 150 J/m2, control cells had 205 6-TG-resistant colonies per 10(6) cells, while denV-transfected cells had 61 mutant colonies.	Thioguanine	263-265	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	93-97
7688082-2	1993	PCR analyses of 71 independent, 6-thioguanine (TG)-resistant sublines isolated from Aphr-4-2 or parental V79-743X cells using hprt exon 3- and exon 9-specific oligonucleotide primer pairs revealed the loss of exon 3 or 9 from 6 of 60 Aphr-4-2 derived-, and from 1 of 11 parental V79-derived, TG-resistant mutants.	Thioguanine	47-49	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	126-130
8281308-4	1993	PP90 was phosphorylated under conditions that excluded enzyme activities due to Ca2+/calmodulin kinases, cyclic nucleotide-dependent kinases or protein kinase C. On the other hand, the phosphorylation could be selectively inhibited by the purine analogues adenosine, 2-aminopurine and 6-thioguanine (6-TG).	Thioguanine	285-298	calnexin	Canis lupus familiaris	0-4
8281308-4	1993	PP90 was phosphorylated under conditions that excluded enzyme activities due to Ca2+/calmodulin kinases, cyclic nucleotide-dependent kinases or protein kinase C. On the other hand, the phosphorylation could be selectively inhibited by the purine analogues adenosine, 2-aminopurine and 6-thioguanine (6-TG).	Thioguanine	300-304	calnexin	Canis lupus familiaris	0-4
7688087-0	1993	Coamplification of hprt cDNA and gamma T-cell receptor sequences from 6-thioguanine resistant human T-lymphocytes.	Thioguanine	70-83	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	19-23
8510520-2	1993	The objective of this study was to test the hypothesis that parenteral LCT require more extensive modification via hydrolysis and reesterification (triglyceride-free fatty acid [TG-FFA] recycling) for effective utilization, whereas MCT and SL do not.	Thioguanine	178-180	lactase	Rattus norvegicus	71-74
8367592-2	1993	Four independent experiments yielded approximately 7 x 10(3) and 3.2 x 10(3) initial surviving 6-thioguanine-resistant (6-TGr) mutants in X-ray-treated and untreated cultures, respectively.	Thioguanine	95-108	thioredoxin reductase 3	Homo sapiens	122-125
7686258-2	1993	Hprt- mutants from treated animals were isolated by culturing splenic T-cells in microtiter dishes containing medium supplemented with IL-2, concanavalin A, and 6-thioguanine.	Thioguanine	161-174	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	0-4
8379213-2	1993	The sister chromatid exchange (SCE) assay and the gene mutation assay for 6-thioguanine resistance (HPRT) were carried out with Chinese hamster ovary (CHO) cells.	Thioguanine	74-87	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	100-104
8318412-2	1993	6-Thioguanine (6-TG), a closely related thiopurine, is less affected by that enzyme and so it may be a more reliable drug-at least for patients with constitutionally high TPMT activity.	Thioguanine	0-13	thiopurine S-methyltransferase	Homo sapiens	171-175
8318412-2	1993	6-Thioguanine (6-TG), a closely related thiopurine, is less affected by that enzyme and so it may be a more reliable drug-at least for patients with constitutionally high TPMT activity.	Thioguanine	15-19	thiopurine S-methyltransferase	Homo sapiens	171-175
8352451-3	1993	The first-phase insulin response was increased by 116% in the TG group and decreased by 59% in the TG-DM group.	Thioguanine	62-64	insulin	Homo sapiens	16-23
8352451-3	1993	The first-phase insulin response was increased by 116% in the TG group and decreased by 59% in the TG-DM group.	Thioguanine	99-101	insulin	Homo sapiens	16-23
8352451-5	1993	The mean insulin sensitivity index (SI) was reduced by 50% in the TG group and by 60% in the TG-DM group.	Thioguanine	66-68	insulin	Homo sapiens	9-16
8352451-5	1993	The mean insulin sensitivity index (SI) was reduced by 50% in the TG group and by 60% in the TG-DM group.	Thioguanine	93-95	insulin	Homo sapiens	9-16
7685057-7	1993	Molecular screening of the locus showed that the number of deleted exons was significantly higher in induced than in spontaneous TG-resistant clones, suggesting that the genetic damages induced by electroporation concern the loss of regions well over the size of the hprt locus.	Thioguanine	129-131	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	267-271
7685488-1	1993	Ethylene oxide (EtO)-induced mutations in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene were characterized in 28 independently derived 6-thioguanine-resistant human diploid fibroblast clones using polymerase chain reaction-based techniques and Southern blot analysis.	Thioguanine	152-165	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	94-98
8450767-1	1993	The molecular basis of somatic mutation at the hypoxanthine-guanine phosphoribosyl-transferase (hprt) locus in human 6-thioguanine resistant T-cell clones from 17 individuals has been studied by Southern blot analysis, multiplex PCR (polymerase chain reaction) and direct sequencing of PCR amplified hprt cDNAs or genomic DNA.	Thioguanine	117-130	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	47-94
7681532-0	1993	Hprt activities and RNA phenotypes in 6-thioguanine resistant human T-lymphocytes.	Thioguanine	38-51	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-4
7681532-1	1993	The phenotypic effects of mutation in the hypoxanthine phosphoribosyltransferase (hprt) gene on hprt enzyme activity and hprt mRNA levels were studied in 6-thioguanine (TG) resistant human T-cell clones with various types of hprt mutation.	Thioguanine	154-167	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	82-86
7681532-1	1993	The phenotypic effects of mutation in the hypoxanthine phosphoribosyltransferase (hprt) gene on hprt enzyme activity and hprt mRNA levels were studied in 6-thioguanine (TG) resistant human T-cell clones with various types of hprt mutation.	Thioguanine	169-171	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	82-86
8319643-4	1993	In addition, we examined the adducts present in spleen lymphocytes and assayed for the induction of mutations at the hypoxanthine-guanine phosphoribosyltransferase locus in these cells, as measured by the frequency of 6-thioguanine-resistant (TGr) T-lymphocytes.	Thioguanine	218-231	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	117-163
8450767-1	1993	The molecular basis of somatic mutation at the hypoxanthine-guanine phosphoribosyl-transferase (hprt) locus in human 6-thioguanine resistant T-cell clones from 17 individuals has been studied by Southern blot analysis, multiplex PCR (polymerase chain reaction) and direct sequencing of PCR amplified hprt cDNAs or genomic DNA.	Thioguanine	117-130	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	96-100
1461142-1	1992	We have recently reported that the apolipoprotein (apo) B-100-apo(a) complex, the protein moiety of lipoprotein(a) [Lp(a)], has a high affinity for triglyceride(TG)-rich particles (TRP) and that this complex can affiliate with endogenous TG-rich lipoproteins.	Thioguanine	161-163	lipoprotein(a)	Homo sapiens	100-114
7680248-2	1993	The analogue 6-thioguanine (6-TG) has been shown to inhibit with high specificity protein kinase N (PKN), a serine/threonine protein kinase activated by NGF in several cellular systems.	Thioguanine	13-26	protein kinase N1	Rattus norvegicus	82-98
7680248-2	1993	The analogue 6-thioguanine (6-TG) has been shown to inhibit with high specificity protein kinase N (PKN), a serine/threonine protein kinase activated by NGF in several cellular systems.	Thioguanine	13-26	protein kinase N1	Rattus norvegicus	100-103
7680248-2	1993	The analogue 6-thioguanine (6-TG) has been shown to inhibit with high specificity protein kinase N (PKN), a serine/threonine protein kinase activated by NGF in several cellular systems.	Thioguanine	28-32	protein kinase N1	Rattus norvegicus	82-98
7680248-2	1993	The analogue 6-thioguanine (6-TG) has been shown to inhibit with high specificity protein kinase N (PKN), a serine/threonine protein kinase activated by NGF in several cellular systems.	Thioguanine	28-32	protein kinase N1	Rattus norvegicus	100-103
7680248-6	1993	The analogue 6-TG inhibited the NGF-inducible p75-associated kinase activity with an IC50 in the range of 15-35 microM.	Thioguanine	13-17	nerve growth factor receptor	Rattus norvegicus	46-49
7680248-9	1993	Application of either 2-aminopurine or 6-TG to intact cells only slightly inhibit the NGF-dependent induction of the purine-analogue-inhibited p75-associated kinase activity.	Thioguanine	39-43	nerve growth factor receptor	Rattus norvegicus	143-146
1461142-1	1992	We have recently reported that the apolipoprotein (apo) B-100-apo(a) complex, the protein moiety of lipoprotein(a) [Lp(a)], has a high affinity for triglyceride(TG)-rich particles (TRP) and that this complex can affiliate with endogenous TG-rich lipoproteins.	Thioguanine	161-163	lipoprotein(a)	Homo sapiens	116-121
1434805-7	1992	These data suggest a possible new explanation of the synergism of HDMTX and 6-thiopurines, for example 6-mercaptopurine and 6-thioguanine, since plasma Hx is considered to counteract 6-thiopurine toxicity through competition at the level of HGPRT.	Thioguanine	124-137	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	241-246
1306134-1	1992	Molecular characterization of in vivo mutation at the human hypoxanthine phosphoribosyltransferase (hprt) locus has revealed a broad spectrum of mutation, both with regard to germ-line mutation in Lesch-Nyhan and gout patients, and somatic mutation in 6-thioguanine resistant T-lymphocytes from healthy individuals.	Thioguanine	252-265	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	60-98
1306134-1	1992	Molecular characterization of in vivo mutation at the human hypoxanthine phosphoribosyltransferase (hprt) locus has revealed a broad spectrum of mutation, both with regard to germ-line mutation in Lesch-Nyhan and gout patients, and somatic mutation in 6-thioguanine resistant T-lymphocytes from healthy individuals.	Thioguanine	252-265	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-104
1568789-1	1992	Decreased activity of hypoxanthine-guanine phosphoribosyl-transferase (HGPRT), responsible for the conversion of 6-mercaptopurine and 6-thioguanine (6-TG) to their cytotoxic nucleotides, may cause resistance to these thiopurines in experimental leukemic systems.	Thioguanine	134-147	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	22-69
1518807-2	1992	Hprt- mutants were isolated by culturing splenic T cells in microtiter dishes containing medium supplemented with interleukin 2, concanavalin A, and 6-thioguanine.	Thioguanine	149-162	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	0-4
1584799-2	1992	An average of 1.6 x 10(4) 6-thioguanine-resistant mutants were created per experiment and the kinds, positions, and numbers of the most frequent mutations were examined in exon 3 of the HPRT gene by using a high-fidelity polymerase chain reaction and denaturing gradient gel electrophoresis.	Thioguanine	26-39	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	186-190
1279353-2	1992	Cerebellar Purkinje neurons, long considered to be GABAergic, showed high levels of TH mRNA in the caudal vermis and the lateral hemispheres of the cerebellum of tg/tg, tg/tgla, and tgla/tgla mice.	Thioguanine	162-164	tyrosine hydroxylase	Mus musculus	84-86
1279353-2	1992	Cerebellar Purkinje neurons, long considered to be GABAergic, showed high levels of TH mRNA in the caudal vermis and the lateral hemispheres of the cerebellum of tg/tg, tg/tgla, and tgla/tgla mice.	Thioguanine	165-167	tyrosine hydroxylase	Mus musculus	84-86
1279353-2	1992	Cerebellar Purkinje neurons, long considered to be GABAergic, showed high levels of TH mRNA in the caudal vermis and the lateral hemispheres of the cerebellum of tg/tg, tg/tgla, and tgla/tgla mice.	Thioguanine	165-167	tyrosine hydroxylase	Mus musculus	84-86
1638685-2	1992	In the present study we determined (i) loss of colony-forming ability and frequency of mutants resistant to 6-thioguanine (6TG) on exposure to the SN1 alkylating agent methylnitrosourea (MNU) and (ii) amount of O6-methylguanine-DNA methyltransferase (MGMT), the protein responsible for repairing O6-methylguanine (O6mG) produced by MNU, in GM11 cells compared to GM10, a Mer+ human fetal fibroblast strain.	Thioguanine	108-121	solute carrier family 38 member 3	Homo sapiens	147-150
1638685-2	1992	In the present study we determined (i) loss of colony-forming ability and frequency of mutants resistant to 6-thioguanine (6TG) on exposure to the SN1 alkylating agent methylnitrosourea (MNU) and (ii) amount of O6-methylguanine-DNA methyltransferase (MGMT), the protein responsible for repairing O6-methylguanine (O6mG) produced by MNU, in GM11 cells compared to GM10, a Mer+ human fetal fibroblast strain.	Thioguanine	123-126	solute carrier family 38 member 3	Homo sapiens	147-150
1638685-2	1992	In the present study we determined (i) loss of colony-forming ability and frequency of mutants resistant to 6-thioguanine (6TG) on exposure to the SN1 alkylating agent methylnitrosourea (MNU) and (ii) amount of O6-methylguanine-DNA methyltransferase (MGMT), the protein responsible for repairing O6-methylguanine (O6mG) produced by MNU, in GM11 cells compared to GM10, a Mer+ human fetal fibroblast strain.	Thioguanine	123-126	O-6-methylguanine-DNA methyltransferase	Homo sapiens	211-249
1638685-2	1992	In the present study we determined (i) loss of colony-forming ability and frequency of mutants resistant to 6-thioguanine (6TG) on exposure to the SN1 alkylating agent methylnitrosourea (MNU) and (ii) amount of O6-methylguanine-DNA methyltransferase (MGMT), the protein responsible for repairing O6-methylguanine (O6mG) produced by MNU, in GM11 cells compared to GM10, a Mer+ human fetal fibroblast strain.	Thioguanine	123-126	O-6-methylguanine-DNA methyltransferase	Homo sapiens	251-255
1639404-1	1992	We have determined the nucleotide sequences of 10 intragenic human HPRT gene deletion junctions isolated from thioguanine-resistant PSV811 Werner syndrome fibroblasts or from HL60 myeloid leukemia cells.	Thioguanine	110-121	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	67-71
1639404-5	1992	Each mutant contained the deletion of one or more HPRT exon, thus explaining the thioguanine-resistant cellular phenotype.	Thioguanine	81-92	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	50-54
1568789-1	1992	Decreased activity of hypoxanthine-guanine phosphoribosyl-transferase (HGPRT), responsible for the conversion of 6-mercaptopurine and 6-thioguanine (6-TG) to their cytotoxic nucleotides, may cause resistance to these thiopurines in experimental leukemic systems.	Thioguanine	134-147	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	71-76
1568789-1	1992	Decreased activity of hypoxanthine-guanine phosphoribosyl-transferase (HGPRT), responsible for the conversion of 6-mercaptopurine and 6-thioguanine (6-TG) to their cytotoxic nucleotides, may cause resistance to these thiopurines in experimental leukemic systems.	Thioguanine	149-153	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	22-69
1568789-1	1992	Decreased activity of hypoxanthine-guanine phosphoribosyl-transferase (HGPRT), responsible for the conversion of 6-mercaptopurine and 6-thioguanine (6-TG) to their cytotoxic nucleotides, may cause resistance to these thiopurines in experimental leukemic systems.	Thioguanine	149-153	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	71-76
1568789-12	1992	We conclude that: (a) HGPRT is lower in T- than in B-lineage ALL and is constant in sequential differentiation stages of B-lineage ALL; (b) HGPRT activity is inversely related to tumor load; (c) low HGPRT activities are correlated with a poorer prognosis in precursor B-ALL but this cannot be explained by thiopurine resistance because (d) there is no relation between HGPRT activity and in vitro 6-TG resistance.	Thioguanine	397-401	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	22-27
1311636-3	1992	The end point used was the induction of mutations in the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus, selected using 6-thioguanine resistance (TGr).	Thioguanine	134-147	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	57-103
1397477-5	1992	The marked BZF-induced Tg reduction was associated with a proportional decrease in Apo B, while an increase in total HDL-, HDL2 and HDL3-CHOL, together with a significant increase in Apo AI, was observed.	Thioguanine	23-25	apolipoprotein B	Homo sapiens	83-88
1311306-1	1992	Human B lymphoblast lines severely deficient in hypoxanthine-guanine phosphoribosyltransferase (HGPRT) were selected for resistance to 6-thioguanine from cloned normal and phosphoribosylpyrophosphate (PP-Rib-P) synthetase-superactive cell lines and were compared with their respective parental cell lines with regard to growth and PP-Rib-P and purine nucleotide metabolism.	Thioguanine	135-148	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	48-94
1311306-1	1992	Human B lymphoblast lines severely deficient in hypoxanthine-guanine phosphoribosyltransferase (HGPRT) were selected for resistance to 6-thioguanine from cloned normal and phosphoribosylpyrophosphate (PP-Rib-P) synthetase-superactive cell lines and were compared with their respective parental cell lines with regard to growth and PP-Rib-P and purine nucleotide metabolism.	Thioguanine	135-148	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	96-101
1318283-2	1992	The amounts of plasma VLDL and VLDL-triglycerides (VLDL-TG) were significantly higher in the fat line than in the lean one.	Thioguanine	56-58	very low density lipoprotein receptor	Gallus gallus	22-26
1318283-2	1992	The amounts of plasma VLDL and VLDL-triglycerides (VLDL-TG) were significantly higher in the fat line than in the lean one.	Thioguanine	56-58	very low density lipoprotein receptor	Gallus gallus	31-35
1318283-2	1992	The amounts of plasma VLDL and VLDL-triglycerides (VLDL-TG) were significantly higher in the fat line than in the lean one.	Thioguanine	56-58	very low density lipoprotein receptor	Gallus gallus	31-35
1318283-6	1992	A positive correlation between plasma VLDL-TG concentration and hepatic delta 9 desaturase activity in the fat line animals strongly suggests that availability of monoenoic fatty acids is involved in the control of VLDL assembly and secretion.	Thioguanine	43-45	very low density lipoprotein receptor	Gallus gallus	38-42
1318283-6	1992	A positive correlation between plasma VLDL-TG concentration and hepatic delta 9 desaturase activity in the fat line animals strongly suggests that availability of monoenoic fatty acids is involved in the control of VLDL assembly and secretion.	Thioguanine	43-45	stearoyl-CoA desaturase	Gallus gallus	72-90
1318283-6	1992	A positive correlation between plasma VLDL-TG concentration and hepatic delta 9 desaturase activity in the fat line animals strongly suggests that availability of monoenoic fatty acids is involved in the control of VLDL assembly and secretion.	Thioguanine	43-45	very low density lipoprotein receptor	Gallus gallus	215-219
1373820-8	1992	The suitability of the hprt gene as target for mutational analysis is demonstrated by the fact that amino acid changes in at least 151 of the 218 amino acid residues of the hprt protein result in a 6-thioguanine-resistant phenotype.	Thioguanine	198-211	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	23-27
1373820-8	1992	The suitability of the hprt gene as target for mutational analysis is demonstrated by the fact that amino acid changes in at least 151 of the 218 amino acid residues of the hprt protein result in a 6-thioguanine-resistant phenotype.	Thioguanine	198-211	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	173-177
1311636-3	1992	The end point used was the induction of mutations in the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus, selected using 6-thioguanine resistance (TGr).	Thioguanine	134-147	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	105-110
1572065-1	1992	Hippocampal CA3 pyramidal neurons in the adult epileptic mutant mouse tottering (tg) show normal intrinsic membrane properties, yet fire abnormally prolonged paroxysmal depolarizing shifts (PDS) during in vitro exposure to elevated extracellular potassium solutions.	Thioguanine	81-83	carbonic anhydrase 3	Mus musculus	12-15
1579070-3	1992	This paper shows that the 200 degrees C extract also causes mutations at the hprt locus in normal human fibroblasts, as demonstrated by a dose-dependent increase of 6-thioguanine resistant mutants.	Thioguanine	165-178	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	77-81
1542591-0	1992	Dinucleotide repeat (TG)23 polymorphism in the MAOB gene.	Thioguanine	21-23	monoamine oxidase B	Homo sapiens	47-51
1540146-6	1992	Secondly, we compared seven aza-adenine-resistant and 14 thioguanine-resistant mutants of AT3-2 and found significant differences in control and insulin-stimulated rates of protein turnover both within and between mutant populations.	Thioguanine	57-68	insulin	Cricetulus griseus	145-152
1505529-4	1992	The induction of 6-thioguanine resistant mutants was evaluated using the well-established CHO/hypoxanthine-guanine phosphoribosyl transferase (HGPRT) assay.	Thioguanine	17-30	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	143-148
1309569-2	1992	Purine analogs, such as 6-thioguanine and 2-aminopurine, have been found to inhibit PKN in vitro.	Thioguanine	24-37	protein kinase N1	Rattus norvegicus	84-87
1734447-6	1992	Mutations were scored at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus using 6-thio-guanine (6-TG) for selection.	Thioguanine	96-110	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	29-76
1734447-6	1992	Mutations were scored at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus using 6-thio-guanine (6-TG) for selection.	Thioguanine	96-110	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	78-82
1734447-6	1992	Mutations were scored at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus using 6-thio-guanine (6-TG) for selection.	Thioguanine	112-116	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	29-76
1734447-6	1992	Mutations were scored at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus using 6-thio-guanine (6-TG) for selection.	Thioguanine	112-116	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	78-82
1505529-4	1992	The induction of 6-thioguanine resistant mutants was evaluated using the well-established CHO/hypoxanthine-guanine phosphoribosyl transferase (HGPRT) assay.	Thioguanine	17-30	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	90-141
1370727-3	1992	Alterations in the HPRT gene of at least 10 independent 6-thioguanine-resistant (TGr) clones mutated by each chemical were analyzed using 8 different restriction endonucleases; Hind III, EcoRI, BamHI, XbaI, Hae III, XhoI, MspI and PstI, and a full-length HPRT cDNA as a probe in molecular hybridization.	Thioguanine	56-69	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	19-23
1317271-0	1992	[Establishment and characteristics of a lymphoblastoid cell line (CKM) resistant to 6-TG and ouabain].	Thioguanine	84-88	creatine kinase, M-type	Homo sapiens	66-69
1317271-8	1992	CKM-8 has been modified to be resistant to both thioguanine (30 micrograms/ml) and Ouabain (10(-5)) for the production of human-human hybridomas.	Thioguanine	48-59	creatine kinase, M-type	Homo sapiens	0-3
1730527-2	1992	Mutations at the hypoxanthine-guanine phophoribosyltransferase (HPRT) locus were quantified by determining the 6-thioguanine resistance.	Thioguanine	111-124	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-62
1730527-2	1992	Mutations at the hypoxanthine-guanine phophoribosyltransferase (HPRT) locus were quantified by determining the 6-thioguanine resistance.	Thioguanine	111-124	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	64-68
1732105-1	1992	Molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) cDNA from 6-thioguanine-resistant T-lymphocytes cloned from smoking and non-smoking adult donors showed that 35% of these mutants were defective in splicing of hprt mRNA.	Thioguanine	86-99	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	22-68
1732105-1	1992	Molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) cDNA from 6-thioguanine-resistant T-lymphocytes cloned from smoking and non-smoking adult donors showed that 35% of these mutants were defective in splicing of hprt mRNA.	Thioguanine	86-99	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	70-74
1834524-2	1991	This construct permits cell growth in hypoxanthine/aminopterin/thymidine media and confers 6-thioguanine sensitivity upon mouse Hprt- embryonic stem cells, allowing either positive or negative selection in gene-targeting experiments.	Thioguanine	91-104	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	128-132
1355109-4	1992	The latter elevations actually induced significantly smaller increases in the CA1 synaptic responses of tg/tg as compared to normal slices.	Thioguanine	104-106	carbonic anhydrase 1	Mus musculus	78-81
1355109-4	1992	The latter elevations actually induced significantly smaller increases in the CA1 synaptic responses of tg/tg as compared to normal slices.	Thioguanine	107-109	carbonic anhydrase 1	Mus musculus	78-81
1722592-6	1991	This novel pattern of methylation showed no preference for CpG dinucleotides, but was nevertheless found capable of silencing HPRT gene expression and producing a condition of resistance to 6-thioguanine.	Thioguanine	190-203	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	126-130
1759989-8	1991	Linear regression analysis showed that positive correlates of the serum CETP levels in all subjects were: IDL-EC (r = 0.463), HDL-TG (r = 0.603) and VLDL- and IDL-EC/TG ratio (r = 0.698 and 0.843).	Thioguanine	130-132	cholesteryl ester transfer protein	Homo sapiens	72-76
1759989-8	1991	Linear regression analysis showed that positive correlates of the serum CETP levels in all subjects were: IDL-EC (r = 0.463), HDL-TG (r = 0.603) and VLDL- and IDL-EC/TG ratio (r = 0.698 and 0.843).	Thioguanine	166-168	cholesteryl ester transfer protein	Homo sapiens	72-76
1922146-1	1991	The clonal assay was used to measure frequencies of 6-thioguanine-resistant (HPRT) T-lymphocytes in 111 donors from the following 5 control populations: 55 adult healthy volunteers; 20 untreated cancer patients; 8 healthy hospital workers serving as controls for 9 hospital workers sterilizing equipment with ethylene oxide; 15 factory workers serving as controls for 15 workers occupationally exposed to high doses of ethylene oxide; 13 pretreatment samples from donors undergoing a diagnostic test with Technetium-99m for an analysis of heart function.	Thioguanine	52-65	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	77-81
1712423-2	1991	43% of the BLM-induced thioguanine-resistant mutants suffer from large alterations of hprt DNA sequences.	Thioguanine	23-34	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	86-90
1895953-6	1991	VLDL-TG from fructose and VLDL-TG from glucose donors was lipolyzed with PHP LPL and HL from normal rats.	Thioguanine	5-7	lipoprotein lipase	Rattus norvegicus	77-80
1940062-6	1991	Multiple regression analysis in PCO women, after adjustment for age, body mass index and the levels of insulin and sex hormones, showed a strong positive correlation between the fasting insulin levels and total triglycerides and VLDL-TG, while a negative correlation was found between fasting insulin levels and apo A-I.	Thioguanine	234-236	insulin	Homo sapiens	103-110
1940062-6	1991	Multiple regression analysis in PCO women, after adjustment for age, body mass index and the levels of insulin and sex hormones, showed a strong positive correlation between the fasting insulin levels and total triglycerides and VLDL-TG, while a negative correlation was found between fasting insulin levels and apo A-I.	Thioguanine	234-236	insulin	Homo sapiens	186-193
1940062-6	1991	Multiple regression analysis in PCO women, after adjustment for age, body mass index and the levels of insulin and sex hormones, showed a strong positive correlation between the fasting insulin levels and total triglycerides and VLDL-TG, while a negative correlation was found between fasting insulin levels and apo A-I.	Thioguanine	234-236	insulin	Homo sapiens	186-193
1712425-1	1991	HPRT mutant clones of V79 Chinese hamster cells, isolated after 6-thioguanine (6TG) selection, normally exhibit sensitivity to growth in medium containing the folic acid inhibitor aminopterin or the glutamine analogue L-azaserine (e.g., HAT or HAsT medium).	Thioguanine	64-77	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	0-4
1712425-1	1991	HPRT mutant clones of V79 Chinese hamster cells, isolated after 6-thioguanine (6TG) selection, normally exhibit sensitivity to growth in medium containing the folic acid inhibitor aminopterin or the glutamine analogue L-azaserine (e.g., HAT or HAsT medium).	Thioguanine	79-82	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	0-4
1827755-4	1991	Leukosialin from RA-resistant and 6-TG-resistant HL-60 sublines migrated much more slowly than those from wild-type HL-60 cells when applied to sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Thioguanine	34-38	LOC105369247	Homo sapiens	0-11
1827755-9	1991	Among them, Gal beta 1----3GalNAc alpha 2----3sialyltransferase and Gal beta 1----4(3)GlcNAc alpha 2----3sialyltransferase were much lower in the RA- or 6-TG-resistant HL-60 subline than in wild-type HL-60 cells.	Thioguanine	153-157	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	12-63
1891494-4	1991	The extract also showed decreased mutation frequency when mutagenicity was examined using V79 cells at the hypoxanthine-guanine phosphoribosyl transferase locus as resistance to 6-thioguanine after exposure to methyl methanesulfonate.	Thioguanine	178-191	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	107-154
1892484-7	1991	The reduction rates of plasma TC, TG and apo A-I levels of HDL2 were 43.0%, 43.6% and 47.0%.	Thioguanine	34-36	junctophilin 3	Homo sapiens	59-63
2066754-2	1991	Remission induction therapy consisted of two courses of daunorubicin, cytarabine (Ara-C), and thioguanine (DAT).	Thioguanine	94-105	solute carrier family 6 member 3	Homo sapiens	107-110
1645462-4	1991	6-Thioguanine, an inhibitor of NGF-activated protein kinase N, blocked the survival effects of both NGF and CM on sympathetic neurons, but a dose required for the half-maximal inhibition for the survival effect of CM was 10 times higher than that for NGF.	Thioguanine	0-13	nerve growth factor	Gallus gallus	31-34
1672367-6	1991	Induced mutations at the HPRT locus as determined by 6-thioguanine resistance in normal primary HMEC were not observed following UV radiation.	Thioguanine	53-66	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	25-29
1762116-3	1991	Mutant T-lymphocyte frequency of the HPRT locus detected as resistant to 6-thioguanine significantly increased with DS86 dose however the slope was very shallow compared with that of in vitro study.	Thioguanine	73-86	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	37-41
1645462-4	1991	6-Thioguanine, an inhibitor of NGF-activated protein kinase N, blocked the survival effects of both NGF and CM on sympathetic neurons, but a dose required for the half-maximal inhibition for the survival effect of CM was 10 times higher than that for NGF.	Thioguanine	0-13	nerve growth factor	Gallus gallus	100-103
1645462-4	1991	6-Thioguanine, an inhibitor of NGF-activated protein kinase N, blocked the survival effects of both NGF and CM on sympathetic neurons, but a dose required for the half-maximal inhibition for the survival effect of CM was 10 times higher than that for NGF.	Thioguanine	0-13	nerve growth factor	Gallus gallus	100-103
1702632-0	1990	Inhibition of c-myc expression in human promyelocytic leukemia and colon adenocarcinoma cells by 6-thioguanine.	Thioguanine	97-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-19
1988936-3	1991	The ability of 6-TG to induce differentiation correlates with c-myc mRNA down-regulation, but queuine has no effect on this parameter.	Thioguanine	15-19	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	62-67
1988936-5	1991	Nonetheless, when cells are treated with queuine and 6-TG, they maintain the promyelocytic morphology and are capable of being induced down the monocytic pathway by phorbol 12-myristate 13-acetate as indicated by stabilization of c-fms mRNA and cell adherence.	Thioguanine	53-57	colony stimulating factor 1 receptor	Homo sapiens	230-235
1789219-0	1991	Action and sequence dependent interaction of acivicin and 6-thioguanine in human derived malignant T-ALL and CALLA+ cell lines.	Thioguanine	58-71	membrane metalloendopeptidase	Homo sapiens	109-114
1748085-3	1991	In 1989, we [Yang et al: Gene 83:347-354] described a method to copy mRNA of the hypoxanthine (guanine) phosphoribosyl transferase (HPRT) gene directly from the lysate of a clone of 6-thioguanine-resistant mutant diploid human fibroblasts without the need for RNA extraction or DNA template purification.	Thioguanine	182-195	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	81-130
1748085-3	1991	In 1989, we [Yang et al: Gene 83:347-354] described a method to copy mRNA of the hypoxanthine (guanine) phosphoribosyl transferase (HPRT) gene directly from the lysate of a clone of 6-thioguanine-resistant mutant diploid human fibroblasts without the need for RNA extraction or DNA template purification.	Thioguanine	182-195	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	132-136
1986259-3	1991	The APRT-deficient subclones were, however, significantly more sensitive than wild-type cells to mutagenesis to 5-bromo-2-deoxyuridine resistance and 6-thioguanine resistance by EMS and MMS.	Thioguanine	150-163	adenine phosphoribosyl transferase	Mus musculus	4-8
1702632-6	1990	These actions of TG and inosine on c-myc were also observed in the human colon carcinoma cell line COLO 320, further dissociating some of the effects of TG on c-myc expression from granylocytic differentiation.	Thioguanine	17-19	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	35-40
1702632-6	1990	These actions of TG and inosine on c-myc were also observed in the human colon carcinoma cell line COLO 320, further dissociating some of the effects of TG on c-myc expression from granylocytic differentiation.	Thioguanine	17-19	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-164
1702632-2	1990	In this manner, the treatment of a hypoxanthine phosphoribosyltransferase (HPRT)-deficient HL-60 variant (HL-60/var) with 6-thioguanine (TG) was accompanied by lower c-myc mRNA levels.	Thioguanine	122-135	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	35-73
1702632-2	1990	In this manner, the treatment of a hypoxanthine phosphoribosyltransferase (HPRT)-deficient HL-60 variant (HL-60/var) with 6-thioguanine (TG) was accompanied by lower c-myc mRNA levels.	Thioguanine	122-135	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	75-79
1702632-2	1990	In this manner, the treatment of a hypoxanthine phosphoribosyltransferase (HPRT)-deficient HL-60 variant (HL-60/var) with 6-thioguanine (TG) was accompanied by lower c-myc mRNA levels.	Thioguanine	122-135	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	166-171
1702632-2	1990	In this manner, the treatment of a hypoxanthine phosphoribosyltransferase (HPRT)-deficient HL-60 variant (HL-60/var) with 6-thioguanine (TG) was accompanied by lower c-myc mRNA levels.	Thioguanine	137-139	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	35-73
1702632-2	1990	In this manner, the treatment of a hypoxanthine phosphoribosyltransferase (HPRT)-deficient HL-60 variant (HL-60/var) with 6-thioguanine (TG) was accompanied by lower c-myc mRNA levels.	Thioguanine	137-139	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	75-79
1702632-2	1990	In this manner, the treatment of a hypoxanthine phosphoribosyltransferase (HPRT)-deficient HL-60 variant (HL-60/var) with 6-thioguanine (TG) was accompanied by lower c-myc mRNA levels.	Thioguanine	137-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	166-171
1702632-4	1990	Paradoxically, inhibition of c-myc expression in the wild type HL-60 (HL-60/wt) cell, which is only weakly induced to differentiate by TG, was 5-fold more sensitive to the thiopurine (IC50 = 35 microM).	Thioguanine	135-137	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	29-34
2086495-11	1990	In boys there was a relationship with TG (r = 0.49), with apo B (r = 0.33) and with the apo A-I to apo B ratio (r = -0.24); in girls with TG (r = 0.25), HDL-C (r = -0.39), apo A-I (r = -0.28) and with the HDL-C to TC ratio (r = -0.31); P less than 0.05 for all correlations.	Thioguanine	138-140	apolipoprotein B	Homo sapiens	99-104
2223577-2	1990	The thioguanine-resistant and HAT-sensitive heteromyeloma HAB-1 neither secretes nor contains cytoplasmatic immunoglobulins, the cells being EBV negative but positively stained for HLA-BC and the human proliferation marker Ki-67.	Thioguanine	4-15	HAB1	Homo sapiens	58-63
2233282-2	1990	The patient was homozygous for apolipoprotein (apo) E2, and her very-low-density lipoprotein (VLDL)-cholesterol/serum-triglyceride (TG) ratio of 0.63 was unusually high.	Thioguanine	132-134	apolipoprotein E	Homo sapiens	31-54
2272307-5	1990	We found that the growth of hprt-deficient T-cells is supported in the presence of thioguanine-inactivated wild-type splenocytes up to a cell density of 5 x 10(5) cells per well.	Thioguanine	83-94	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	28-32
2124638-4	1990	The activity of TPA showed no correlation with serum lipids including apolipoproteins, while the levels of PAI-1 antigen showed a positive correlation between TG and beta-Lp (r = 0.292, p less than 0.01, r = 0.211, p less than 0.05).	Thioguanine	159-161	serpin family E member 1	Homo sapiens	107-112
2385237-3	1990	HPRT mutants were selected en masse by resistance to 6-thioguanine.	Thioguanine	53-66	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-4
2318691-5	1990	The dose modification factor of single dose 6-TG (10 mg/kg) is estimated to be 1.47 for Meth-A tumor and 1.25 for RIF tumor.	Thioguanine	44-48	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	Mus musculus	88-106
2162830-12	1990	Epidermal growth factor (EGF) and cAMP derivatives also induce ODC activity in PC12 cells, and these effects were suppressed by 6-TG and 2-AP at concentrations similar to those that affect responses to NGF.	Thioguanine	128-132	epidermal growth factor like 1	Rattus norvegicus	0-23
2162830-12	1990	Epidermal growth factor (EGF) and cAMP derivatives also induce ODC activity in PC12 cells, and these effects were suppressed by 6-TG and 2-AP at concentrations similar to those that affect responses to NGF.	Thioguanine	128-132	epidermal growth factor like 1	Rattus norvegicus	25-28
2162830-12	1990	Epidermal growth factor (EGF) and cAMP derivatives also induce ODC activity in PC12 cells, and these effects were suppressed by 6-TG and 2-AP at concentrations similar to those that affect responses to NGF.	Thioguanine	128-132	ornithine decarboxylase 1	Rattus norvegicus	63-66
2119445-2	1990	In particular, apolipoproteins C-II and C-III (apo C-II and apo C-III) are rapidly transferred from high-density lipoprotein (HDL) to exo TG, and return to HDL after the hydrolysis of exo TG.	Thioguanine	138-140	apolipoprotein C3	Homo sapiens	51-69
2358296-1	1990	The frequency of hprt mutants in peripheral blood T-lymphocytes of two putative Lesch-Nyhan individuals and their parents was determined by a cell cloning assay to quantify the frequency of thioguanine-resistant mutants.	Thioguanine	190-201	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-21
2158624-2	1990	Mutations at the sodium/potassium ATPase and hypoxanthine:guanine phosphoribosyltransferase loci were measured by resistance to ouabain and 6-thioguanine (TG).	Thioguanine	140-153	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	45-91
2158624-2	1990	Mutations at the sodium/potassium ATPase and hypoxanthine:guanine phosphoribosyltransferase loci were measured by resistance to ouabain and 6-thioguanine (TG).	Thioguanine	155-157	hypoxanthine-guanine phosphoribosyltransferase	Rattus norvegicus	45-91
2162830-9	1990	This suggests that 6-TG blocks an early step in the NGF mechanism, and that once this step is triggered, the ODC induction pathway is no longer sensitive to this analogue.	Thioguanine	19-23	nerve growth factor	Rattus norvegicus	52-55
2218724-2	1990	HPRT enzyme levels in cells transfected with mouse HPRT antisense RNA expression vectors are reduced to less than 1% of parental cell activity, resulting in resistance to 6-thioguanine (6TG).	Thioguanine	171-184	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	0-4
2218724-2	1990	HPRT enzyme levels in cells transfected with mouse HPRT antisense RNA expression vectors are reduced to less than 1% of parental cell activity, resulting in resistance to 6-thioguanine (6TG).	Thioguanine	171-184	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	51-55
2218724-2	1990	HPRT enzyme levels in cells transfected with mouse HPRT antisense RNA expression vectors are reduced to less than 1% of parental cell activity, resulting in resistance to 6-thioguanine (6TG).	Thioguanine	186-189	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	0-4
2218724-2	1990	HPRT enzyme levels in cells transfected with mouse HPRT antisense RNA expression vectors are reduced to less than 1% of parental cell activity, resulting in resistance to 6-thioguanine (6TG).	Thioguanine	186-189	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	51-55
1973821-1	1990	We have characterized the structural changes in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of 14 UV-induced, 15 gamma-ray-induced and 17 spontaneous mutants of human lymphoblastoid cells selected for 6-thioguanine (6TG) resistance.	Thioguanine	220-233	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	52-98
1973821-1	1990	We have characterized the structural changes in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of 14 UV-induced, 15 gamma-ray-induced and 17 spontaneous mutants of human lymphoblastoid cells selected for 6-thioguanine (6TG) resistance.	Thioguanine	220-233	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-104
1973821-1	1990	We have characterized the structural changes in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of 14 UV-induced, 15 gamma-ray-induced and 17 spontaneous mutants of human lymphoblastoid cells selected for 6-thioguanine (6TG) resistance.	Thioguanine	235-238	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	52-98
1973821-1	1990	We have characterized the structural changes in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of 14 UV-induced, 15 gamma-ray-induced and 17 spontaneous mutants of human lymphoblastoid cells selected for 6-thioguanine (6TG) resistance.	Thioguanine	235-238	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-104
2397544-6	1990	Before and after the treatment, the values of RBC, SI, Hb, SIBC, MCH in 20 cases of TG turned significantly better (P less than 0.01), but 17 cases of CG remained unchanged under the principle.	Thioguanine	84-86	pro-melanin concentrating hormone	Homo sapiens	65-68
33762409-4	2021	6-TG and 6-TGo selectively disrupted the synthesis and maturation of IAV glycoproteins hemagglutinin (HA) and neuraminidase (NA) without affecting the levels of the viral RNAs that encode them.	Thioguanine	0-4	neuraminidase 1	Homo sapiens	110-123
1690319-5	1990	The antiproliferative drugs 6-thioguanine and vincristine both antagonized the neutrophil-granulocyte differentiation inducing action of G-CSF.	Thioguanine	28-41	colony stimulating factor 3	Homo sapiens	137-142
1968499-2	1990	Cell survival and the induction of mutation at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus using resistance to 6-thioguanine (TG) were the endpoints in this study.	Thioguanine	133-146	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	51-98
1968499-2	1990	Cell survival and the induction of mutation at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus using resistance to 6-thioguanine (TG) were the endpoints in this study.	Thioguanine	133-146	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	100-105
1968499-2	1990	Cell survival and the induction of mutation at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus using resistance to 6-thioguanine (TG) were the endpoints in this study.	Thioguanine	148-150	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	51-98
1968499-2	1990	Cell survival and the induction of mutation at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus using resistance to 6-thioguanine (TG) were the endpoints in this study.	Thioguanine	148-150	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	100-105
33941028-8	2021	This study uncovers that the IL1B rs1143634 C/T polymorphism may associate with the risk and blood lipid levels of MI in an Eastern Chinese Han population.Abbreviations: MI: myocardial infarction; IL-1: Interleukin-1; SNP: single nucleotide polymorphism; BMI: Body Mass Index; HDL: high-density lipoprotein; TC: total cholesterol; TG: triglyceride; LDL: low-density lipoprotein; PCR: polymerase chain reaction; 95% CI: 95% confidence interval; OR: odds ratio.	Thioguanine	331-333	interleukin 1 beta	Homo sapiens	29-33
33762409-9	2021	Genetic deletion of PERK enhanced the antiviral effect of 6-TG without causing overt cytotoxicity, suggesting that while UPR activation correlates with diminished viral glycoprotein accumulation, PERK could limit the antiviral effects of drug-induced ER stress.	Thioguanine	58-62	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	20-24
1689076-5	1990	Eleven of 258 thioguanine-resistant (hprt-) T cell clones from five of the six MS patients who were tested proliferated in response to human myelin basic protein without prior in vitro exposure to this antigen.	Thioguanine	14-25	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	37-41
1689076-5	1990	Eleven of 258 thioguanine-resistant (hprt-) T cell clones from five of the six MS patients who were tested proliferated in response to human myelin basic protein without prior in vitro exposure to this antigen.	Thioguanine	14-25	myelin basic protein	Homo sapiens	141-161
2120352-5	1990	Therefore, unmethylation of these CG sites can contribute in preventing mCG----TG/CA changes in this region, which would lead to extensive alterations of the secondary structure of the 5" portion of the HLA-DR alpha MRNA.	Thioguanine	79-81	major histocompatibility complex, class II, DR alpha	Homo sapiens	203-215
30455723-8	2018	Serum SHBG levels were inversely correlated with WHR, trunk fat percentage, glucose, HOMA-IR, TG, UA and DHEAS, and were positively correlated with HDL-C levels (all p &lt;  0.001).	Thioguanine	94-96	sex hormone binding globulin	Homo sapiens	6-10
9092930-4	1997	A HAT (hypoxanthine, aminopterin, thymidine) sensitivity test allowed us to infer that Hprt- clones, selected as 6-thioguanine-resistant clones, possessed mutations at the Hprt locus after 532 nm Nd:YAG laser irradiation.	Thioguanine	113-126	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	87-91
26399628-9	2015	These results demonstrated that SCC and LCB were efficacious in suppressing hepatic SREBP-1c mediated lipogenesis, inhibiting lipid uptake and increasing TG catabolism in the adipose tissue.	Thioguanine	154-156	clathrin, light polypeptide (Lcb)	Mus musculus	40-43
8921909-6	1996	6-Thioguanine (6-TG) resistant colonies were obtained from all the "in-step" cell lines tested at frequencies of 10(-5) to 10(-4), but the frequency of physical loss of the HPRT sequences accompanied by retention of the modified Apob sequence was variable, indicating that mechanisms other than a simple excision are responsible for the generation of 6-TG resistance.	Thioguanine	0-13	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	173-177
8921909-6	1996	6-Thioguanine (6-TG) resistant colonies were obtained from all the "in-step" cell lines tested at frequencies of 10(-5) to 10(-4), but the frequency of physical loss of the HPRT sequences accompanied by retention of the modified Apob sequence was variable, indicating that mechanisms other than a simple excision are responsible for the generation of 6-TG resistance.	Thioguanine	0-13	apolipoprotein B	Homo sapiens	229-233
8921909-6	1996	6-Thioguanine (6-TG) resistant colonies were obtained from all the "in-step" cell lines tested at frequencies of 10(-5) to 10(-4), but the frequency of physical loss of the HPRT sequences accompanied by retention of the modified Apob sequence was variable, indicating that mechanisms other than a simple excision are responsible for the generation of 6-TG resistance.	Thioguanine	15-19	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	173-177
8921909-6	1996	6-Thioguanine (6-TG) resistant colonies were obtained from all the "in-step" cell lines tested at frequencies of 10(-5) to 10(-4), but the frequency of physical loss of the HPRT sequences accompanied by retention of the modified Apob sequence was variable, indicating that mechanisms other than a simple excision are responsible for the generation of 6-TG resistance.	Thioguanine	15-19	apolipoprotein B	Homo sapiens	229-233
25371035-3	2015	The present study explicates the manner in which interval and continuous exercise regimens affect neutrophil-derived microparticle (NDMP) formation and neutrophil/NDMP-mediated thrombin generation (TG) under hypoxic condition.	Thioguanine	198-200	coagulation factor II, thrombin	Homo sapiens	177-185
19447173-6	2009	In addition, diquat exposure induced cardiolipin peroxidation in the liver of Wt mice; the levels of cardiolipin peroxidation were reduced in Tg(GPX4(+/0)) mice but elevated in Gpx4+/- mice.	Thioguanine	142-144	glutathione peroxidase 4	Mus musculus	145-149
9092930-4	1997	A HAT (hypoxanthine, aminopterin, thymidine) sensitivity test allowed us to infer that Hprt- clones, selected as 6-thioguanine-resistant clones, possessed mutations at the Hprt locus after 532 nm Nd:YAG laser irradiation.	Thioguanine	113-126	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	172-176
1383700-1	1992	Molecular alterations were examined in the hypoxanthine guanine phosphoribosyltransferase (hprt) gene of 41 independent X-ray-induced thioguanine-resistant (TGR) Chinese hamster ovary (CHO) cell clones.	Thioguanine	134-145	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	91-95
8422793-8	1993	Total and VLDL TG concentrations were found to be inversely related to rates of insulin-mediated glucose disposal, and HDL cholesterol concentrations were positively related to glucose disposal.	Thioguanine	15-17	insulin	Homo sapiens	80-87
34929517-6	2022	Herein, we describe the design, optimization and biological evaluation studies of a series of novel non-nucleotidic thioguanine based small molecule inhibitors of ENPP1.	Thioguanine	116-127	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	163-168
34763028-10	2022	Combined treatment with 6-TG and DSF/Cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR), suggesting that DSF/Cu promoted 6-TG-induced DNA damage by suppressing ATR protein kinases, therefore enhancing cell apoptosis.	Thioguanine	24-28	ATR serine/threonine kinase	Homo sapiens	108-161
34763028-10	2022	Combined treatment with 6-TG and DSF/Cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR), suggesting that DSF/Cu promoted 6-TG-induced DNA damage by suppressing ATR protein kinases, therefore enhancing cell apoptosis.	Thioguanine	24-28	ATR serine/threonine kinase	Homo sapiens	163-166
34763028-10	2022	Combined treatment with 6-TG and DSF/Cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR), suggesting that DSF/Cu promoted 6-TG-induced DNA damage by suppressing ATR protein kinases, therefore enhancing cell apoptosis.	Thioguanine	24-28	ATR serine/threonine kinase	Homo sapiens	240-243
34763028-10	2022	Combined treatment with 6-TG and DSF/Cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR), suggesting that DSF/Cu promoted 6-TG-induced DNA damage by suppressing ATR protein kinases, therefore enhancing cell apoptosis.	Thioguanine	201-205	ATR serine/threonine kinase	Homo sapiens	108-161
34763028-10	2022	Combined treatment with 6-TG and DSF/Cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR), suggesting that DSF/Cu promoted 6-TG-induced DNA damage by suppressing ATR protein kinases, therefore enhancing cell apoptosis.	Thioguanine	201-205	ATR serine/threonine kinase	Homo sapiens	163-166
34763028-10	2022	Combined treatment with 6-TG and DSF/Cu synergistically reduced the levels of both phosphorylated and total ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR), suggesting that DSF/Cu promoted 6-TG-induced DNA damage by suppressing ATR protein kinases, therefore enhancing cell apoptosis.	Thioguanine	201-205	ATR serine/threonine kinase	Homo sapiens	240-243
34856413-5	2022	In the in vitro cultured chicken primary hepatocytes, adipocytes, and myoblasts, ghrelin suppressed glucose uptake, stimulated fatty acids uptake and oxidation, and decreased TG content.	Thioguanine	175-177	ghrelin/obestatin prepropeptide	Gallus gallus	81-88
34896109-10	2022	This differential mRNA expression was associated with altered SERCA3 protein expression and cytosolic calcium levels with TG exposure.	Thioguanine	122-124	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	62-68
34688878-1	2022	Glycosylation of ApoC-III modulates its function in TG metabolism, with some variants being associated with a more atherogenic lipid profile.	Thioguanine	52-54	apolipoprotein C3	Homo sapiens	17-25
34688878-3	2022	In this study, we aimed to measure the relative content of ApoC-III glycoforms in each lipoprotein fraction as a potential biomarker for TG metabolism and cardiovascular risk.	Thioguanine	137-139	apolipoprotein C3	Homo sapiens	59-67
34688878-12	2022	SIGNIFICANCE: Apo CIII has an important role on plasma TG metabolism through different mechanisms and it is also involved in type 1 and type 2 Diabetes Mellitus.	Thioguanine	55-57	apolipoprotein C3	Homo sapiens	14-22
34956872-0	2021	The Inhibitory Effects of 6-Thioguanine and 6-Mercaptopurine on the USP2a Target Fatty Acid Synthase in Human Submaxillary Carcinoma Cells.	Thioguanine	26-39	fatty acid synthase	Homo sapiens	81-100
34951313-3	2022	Herein, by real-time observation of radical intermediates using time-resolved UV-vis absorption spectroscopy in conjunction with product analysis by HPLC-MS, we discover that UVA excitation of 6-TG triggers direct covalent cross-linking with tryptophan (TrpH) via an exquisite radical mechanism of electron transfer.	Thioguanine	193-197	tryptophan hydroxylase 1	Homo sapiens	254-258
34951313-4	2022	The photoexcitation prepares the redox-active triplet 36-TG*, which initiates electron transfer with TrpH, creating TrpH + and 6-TG - in the first step.	Thioguanine	57-59	tryptophan hydroxylase 1	Homo sapiens	101-105
34951313-4	2022	The photoexcitation prepares the redox-active triplet 36-TG*, which initiates electron transfer with TrpH, creating TrpH + and 6-TG - in the first step.	Thioguanine	57-59	tryptophan hydroxylase 1	Homo sapiens	116-120
34951313-4	2022	The photoexcitation prepares the redox-active triplet 36-TG*, which initiates electron transfer with TrpH, creating TrpH + and 6-TG - in the first step.	Thioguanine	127-131	tryptophan hydroxylase 1	Homo sapiens	101-105
34730435-9	2021	Mechanistic study showed that 6-TG inhibited HSV-1 replication by targeting Rac1 activity in HSV-1 infected cells, and the Rac1 is critical in the pathogenesis of HSK.	Thioguanine	30-34	Rac family small GTPase 1	Homo sapiens	76-80
34921821-6	2022	RESULTS: For the LPL-Hind IIIpolymorphism H+H+ genotype group, the triglycerides TG and very-low-density lipoprotein cholesterol VLDL-C concentrations were significantly higher and the high-density lipoprotein cholesterol HDL-C concentration was significantly lower than those of the H-H- genotype.	Thioguanine	81-83	lipoprotein lipase	Homo sapiens	17-20
34956872-6	2021	Western blot analysis showed that levels of two USP2a target proteins, FAS and Mdm2, were dose-dependently decreased in A253 submaxillary carcinoma cells treated with 6-TG or 6-MP.	Thioguanine	167-171	fatty acid synthase	Homo sapiens	71-74
34956872-6	2021	Western blot analysis showed that levels of two USP2a target proteins, FAS and Mdm2, were dose-dependently decreased in A253 submaxillary carcinoma cells treated with 6-TG or 6-MP.	Thioguanine	167-171	MDM2 proto-oncogene	Homo sapiens	79-83
34956872-9	2021	The effects of 6-TG and 6-MP were not cell type-specific, as they elicited similar decreases in FAS protein in leukemia, prostate and cervical cancer cell lines.	Thioguanine	15-19	fatty acid synthase	Homo sapiens	96-99
34956872-10	2021	6-TG and 6-MP had effects on several cell cycle proteins, including another USP2a target protein, cyclin D1.	Thioguanine	0-4	cyclin D1	Homo sapiens	98-107
34956872-14	2021	In summary, these findings suggest 6-TG and 6-MP reduce the stability of some USP2a targets, including FAS and Mdm2, by inhibiting USP2a-catalyzed deubiquitination in some cancer cells.	Thioguanine	35-39	fatty acid synthase	Homo sapiens	103-106
34956872-14	2021	In summary, these findings suggest 6-TG and 6-MP reduce the stability of some USP2a targets, including FAS and Mdm2, by inhibiting USP2a-catalyzed deubiquitination in some cancer cells.	Thioguanine	35-39	MDM2 proto-oncogene	Homo sapiens	111-115
34956872-15	2021	Our work also provides repurposing evidence supporting 6-TG and 6-MP as target therapeutic drugs, such as USP2a/FAS in this study.	Thioguanine	55-59	fatty acid synthase	Homo sapiens	112-115
34946118-9	2021	The HFHC diet containing beef fat rich in VA had a mild insulin sensitizing effect (p < 0.05, slope of curve), increased plasma HDL cholesterol (p < 0.05, +28%), reduced postprandial plasma TG (p < 0.05), and showed protection from HFHC-induced changes to gut microbial composition in LBW pigs as compared to HFHC diet containing standard beef fat.	Thioguanine	190-192	FAT atypical cadherin 1	Bos taurus	30-33
34887672-7	2021	HCG18 expression in NAFLD patients was related to BMI, HOMA-IR, ALT, FBG, TC, and TG.	Thioguanine	82-84	HLA complex group 18	Homo sapiens	0-5
34097230-6	2021	TG/HDL-C ratio was associated to CETP (p < 0.01) and Lp-PLA2 (p < 0.05).	Thioguanine	0-2	cholesteryl ester transfer protein	Homo sapiens	33-37
34281481-11	2021	Dp3-Sam decreased intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells.	Thioguanine	32-34	APC regulator of WNT signaling pathway	Homo sapiens	0-3
34592905-10	2021	The expression levels of IL-1beta, TNF-alpha, NO, p-P38, P38, p-IkappaBalpha, Caspase1, COX2, and iNOS were measured using ELISAs, qRT-PCR, and western blotting.TG significantly improved the spatial memory and learning abilities of AD mice.	Thioguanine	161-163	interleukin 1 alpha	Mus musculus	25-33
34592905-10	2021	The expression levels of IL-1beta, TNF-alpha, NO, p-P38, P38, p-IkappaBalpha, Caspase1, COX2, and iNOS were measured using ELISAs, qRT-PCR, and western blotting.TG significantly improved the spatial memory and learning abilities of AD mice.	Thioguanine	161-163	tumor necrosis factor	Mus musculus	35-44
34592905-10	2021	The expression levels of IL-1beta, TNF-alpha, NO, p-P38, P38, p-IkappaBalpha, Caspase1, COX2, and iNOS were measured using ELISAs, qRT-PCR, and western blotting.TG significantly improved the spatial memory and learning abilities of AD mice.	Thioguanine	161-163	mitogen-activated protein kinase 14	Mus musculus	52-55
34592905-10	2021	The expression levels of IL-1beta, TNF-alpha, NO, p-P38, P38, p-IkappaBalpha, Caspase1, COX2, and iNOS were measured using ELISAs, qRT-PCR, and western blotting.TG significantly improved the spatial memory and learning abilities of AD mice.	Thioguanine	161-163	mitogen-activated protein kinase 14	Mus musculus	57-76
34592905-10	2021	The expression levels of IL-1beta, TNF-alpha, NO, p-P38, P38, p-IkappaBalpha, Caspase1, COX2, and iNOS were measured using ELISAs, qRT-PCR, and western blotting.TG significantly improved the spatial memory and learning abilities of AD mice.	Thioguanine	161-163	caspase 1	Mus musculus	78-86
34592905-10	2021	The expression levels of IL-1beta, TNF-alpha, NO, p-P38, P38, p-IkappaBalpha, Caspase1, COX2, and iNOS were measured using ELISAs, qRT-PCR, and western blotting.TG significantly improved the spatial memory and learning abilities of AD mice.	Thioguanine	161-163	cytochrome c oxidase II, mitochondrial	Mus musculus	88-92
34592905-10	2021	The expression levels of IL-1beta, TNF-alpha, NO, p-P38, P38, p-IkappaBalpha, Caspase1, COX2, and iNOS were measured using ELISAs, qRT-PCR, and western blotting.TG significantly improved the spatial memory and learning abilities of AD mice.	Thioguanine	161-163	nitric oxide synthase 2, inducible	Mus musculus	98-102
34592905-14	2021	In summary, TG may exert a neuroprotective effect by suppressing the release of inflammatory factors and microglial activity and inhibiting the phosphorylation of IkappaBalpha and p38 MAPK.	Thioguanine	12-14	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	163-175
34592905-14	2021	In summary, TG may exert a neuroprotective effect by suppressing the release of inflammatory factors and microglial activity and inhibiting the phosphorylation of IkappaBalpha and p38 MAPK.	Thioguanine	12-14	mitogen-activated protein kinase 14	Mus musculus	180-188
34410632-5	2021	Slit2 decreased the levels of LDH, CK-MB, cTnI, TG, TC and LDL-C and increased HDL-C level in CHD rats.	Thioguanine	48-50	slit guidance ligand 2	Rattus norvegicus	0-5
34097230-0	2021	Increased Cholesteryl Ester Transfer Protein and Lipoprotein-Associated Phospholipase A2 Activities in Children and Adolescents Presenting High Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio.	Thioguanine	195-197	cholesteryl ester transfer protein	Homo sapiens	10-44
34097230-0	2021	Increased Cholesteryl Ester Transfer Protein and Lipoprotein-Associated Phospholipase A2 Activities in Children and Adolescents Presenting High Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio.	Thioguanine	195-197	phospholipase A2 group VII	Homo sapiens	49-88
34097230-6	2021	TG/HDL-C ratio was associated to CETP (p < 0.01) and Lp-PLA2 (p < 0.05).	Thioguanine	0-2	phospholipase A2 group VII	Homo sapiens	53-60
34678755-1	2021	BACKGROUND: Clinical data on the relationship between TG/HDL ratio and IR suggests that TG/HDL ratio may be a risk factor for insulin resistance.	Thioguanine	54-56	insulin	Homo sapiens	126-133
34800147-8	2021	DX and TG also promoted cell death in OC cells which also increased CRT release.	Thioguanine	7-9	calreticulin	Homo sapiens	68-71
34788284-4	2021	We first found that overexpression of the LD-coating proteins Perilipin 1 or 2 (dPlin1/2), which limit the access of lipases to LDs, markedly increased triacylglyclerol (TG) loaded LDs in neurons.	Thioguanine	170-172	Lipid storage droplet-2	Drosophila melanogaster	62-78
34788284-4	2021	We first found that overexpression of the LD-coating proteins Perilipin 1 or 2 (dPlin1/2), which limit the access of lipases to LDs, markedly increased triacylglyclerol (TG) loaded LDs in neurons.	Thioguanine	170-172	Lipid storage droplet-1	Drosophila melanogaster	80-88
34784445-9	2022	TG in PRP had lower peak height and velocity in DVT+PE and iPE against iDVT.	Thioguanine	0-2	prion protein	Homo sapiens	6-9
34822586-8	2021	Furthermore, downregulation or inhibition of CD36, a known of PPARgamma, alleviated OTA-induced lipid droplets deposition and TG accumulation.	Thioguanine	126-128	peroxisome proliferator activated receptor gamma	Homo sapiens	62-71
34627956-9	2021	CONCLUSION: Ghrelin secretion is modulated in a nutrient-specific manner by proteins and lipids, with TG and AG displaying independent responses to the same stimuli.	Thioguanine	102-104	ghrelin	Mus musculus	12-19
34775377-12	2021	Silencing PVT1 decreased levels of TG, TC, LDL, IL-6, IL-1beta, TNF-alpha, MMP-2, MMP-9, CRP, TIMP-1, MAPK, and NF-kappaB, increased HDL, reduced atherosclerotic plaques and macrophage content in mice, inhibited viability, clones and EdU positive rates in HA-VSMCs, but promoted apoptosis and cell cycle arrest.	Thioguanine	35-37	Pvt1 oncogene	Mus musculus	10-14
34812265-12	2021	The levels of Hcy, MIF, and hs-CRP all shared positive correlations with the TG level and negative correlations with the HDL-C level (all p < 0.001).	Thioguanine	77-79	macrophage migration inhibitory factor	Homo sapiens	19-22
34812265-12	2021	The levels of Hcy, MIF, and hs-CRP all shared positive correlations with the TG level and negative correlations with the HDL-C level (all p < 0.001).	Thioguanine	77-79	C-reactive protein	Homo sapiens	31-34
34480209-9	2021	DNA-incorporated dTG significantly accumulated to a greater extent in lymphocytes from NUDT15 variants when co-cultured with 6-TG ex vivo than in those from non-variants and was associated with decreased proliferation and increased apoptosis.	Thioguanine	125-129	nudix hydrolase 15	Homo sapiens	87-93
34480209-6	2021	The pro-apoptotic effect of DNA-incorporated dTG was examined ex vivo in association with NUDT15 genotypes by co-culturing patient-derived peripheral CD4+ T lymphocytes with 6-thioguanine (6-TG).	Thioguanine	189-193	CD4 molecule	Homo sapiens	150-153
34867822-9	2021	Results: In MetS patients, serum CTRP7 concentrations were significantly higher than in healthy controls, and was positively correlated with WC, BP, FBG, 2h-BG and TG, but negatively correlated with HDL-C and APN.	Thioguanine	164-166	ETS variant transcription factor 3	Homo sapiens	12-16
34867822-9	2021	Results: In MetS patients, serum CTRP7 concentrations were significantly higher than in healthy controls, and was positively correlated with WC, BP, FBG, 2h-BG and TG, but negatively correlated with HDL-C and APN.	Thioguanine	164-166	C1q and TNF related 7	Homo sapiens	33-38
34636169-6	2021	Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration.	Thioguanine	111-122	nudix hydrolase 15	Homo sapiens	5-11
34636169-6	2021	Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration.	Thioguanine	111-122	5'-nucleotidase, cytosolic II	Homo sapiens	33-38
34636169-6	2021	Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration.	Thioguanine	111-122	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	43-48
34636169-6	2021	Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration.	Thioguanine	148-159	nudix hydrolase 15	Homo sapiens	5-11
34636169-6	2021	Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration.	Thioguanine	148-159	5'-nucleotidase, cytosolic II	Homo sapiens	33-38
34636169-6	2021	Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration.	Thioguanine	148-159	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	43-48
34391825-3	2021	Alterations in the TG concentration and the AG/DAG ratio may be implicated in conditions involving energy imbalances and insulin resistant states (e.g., metabolic syndrome or Type 2 diabetes mellitus).	Thioguanine	19-21	insulin	Homo sapiens	121-128
34708625-8	2021	These results identify a critical role of TG-RPR in proliferation and apoptosis of HepG2 cells via modulating PTEN/PI3K/Akt signaling pathway.	Thioguanine	42-44	phosphatase and tensin homolog	Homo sapiens	110-114
34632326-0	2021	6-Thioguanine Blocks SARS-CoV-2 Replication by Inhibition of PLpro.	Thioguanine	0-13	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	61-66
34632326-4	2021	6-TG also inhibited PLpro-catalyzed polyprotein cleavage and de-ISGylation in cells and inhibited proteolytic activity of the purified PLpro domain in vitro.	Thioguanine	0-4	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	20-25
34632326-4	2021	6-TG also inhibited PLpro-catalyzed polyprotein cleavage and de-ISGylation in cells and inhibited proteolytic activity of the purified PLpro domain in vitro.	Thioguanine	0-4	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	135-140
34396783-10	2021	Our data suggest that hepatocyte ANGPTL4 does not directly regulate triglyceride partitioning, but that loss of liver-derived ANGPTL4 may be protective from HFD-induced glucose intolerance and influence plasma TG metabolism during prolonged fasting.	Thioguanine	210-212	angiopoietin-like 4	Mus musculus	33-40
34396783-10	2021	Our data suggest that hepatocyte ANGPTL4 does not directly regulate triglyceride partitioning, but that loss of liver-derived ANGPTL4 may be protective from HFD-induced glucose intolerance and influence plasma TG metabolism during prolonged fasting.	Thioguanine	210-212	angiopoietin-like 4	Mus musculus	126-133
34598675-8	2021	The mean values of BMI, SBP, DBP, TC, TG, and LDL-C were found to be increased with elevated levels of serum ALT and AST in the quartiles (P for trend < 0.05).	Thioguanine	38-40	solute carrier family 17 member 5	Homo sapiens	117-120
34452592-1	2021	INTRODUCTION: Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, such as mercaptopurine and tioguanine (TG), fundamental chemotherapeutic agents used in the treatment of acute lymphoblastic leukemia (ALL).	Thioguanine	121-131	thiopurine S-methyltransferase	Homo sapiens	14-42
34452592-1	2021	INTRODUCTION: Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, such as mercaptopurine and tioguanine (TG), fundamental chemotherapeutic agents used in the treatment of acute lymphoblastic leukemia (ALL).	Thioguanine	121-131	thiopurine S-methyltransferase	Homo sapiens	44-48
34452592-1	2021	INTRODUCTION: Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, such as mercaptopurine and tioguanine (TG), fundamental chemotherapeutic agents used in the treatment of acute lymphoblastic leukemia (ALL).	Thioguanine	133-135	thiopurine S-methyltransferase	Homo sapiens	14-42
34452592-1	2021	INTRODUCTION: Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, such as mercaptopurine and tioguanine (TG), fundamental chemotherapeutic agents used in the treatment of acute lymphoblastic leukemia (ALL).	Thioguanine	133-135	thiopurine S-methyltransferase	Homo sapiens	44-48
34435580-7	2021	In addition, the data revealed that different genotype carriers of the CD14 C-260 T polymorphism showed significantly distinct TG levels in MI patients.	Thioguanine	127-129	CD14 molecule	Homo sapiens	71-75
34708625-8	2021	These results identify a critical role of TG-RPR in proliferation and apoptosis of HepG2 cells via modulating PTEN/PI3K/Akt signaling pathway.	Thioguanine	42-44	AKT serine/threonine kinase 1	Homo sapiens	120-123
34556022-10	2021	6-thioguanine, Doxazosin, and Emetine had potential value in the clinical application of drugs targeting GINS4.	Thioguanine	0-13	GINS complex subunit 4	Homo sapiens	105-110
34521801-0	2021	Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine.	Thioguanine	158-171	thiopurine S-methyltransferase	Homo sapiens	21-51
34587962-11	2021	The levels of TG, TC, LDL-C and Apo-B depended significantly on AF and APOE allele groups, and statistically significant interactions between AF and APOE allele were observed in the above 4 variables, although the APOE gene SNPs (rs429358 and rs7412) were no significant risk for AF incidence.	Thioguanine	14-16	apolipoprotein E	Homo sapiens	71-75
34587962-11	2021	The levels of TG, TC, LDL-C and Apo-B depended significantly on AF and APOE allele groups, and statistically significant interactions between AF and APOE allele were observed in the above 4 variables, although the APOE gene SNPs (rs429358 and rs7412) were no significant risk for AF incidence.	Thioguanine	14-16	apolipoprotein E	Homo sapiens	149-153
34419063-10	2021	Moreover, serum asprosin levels directly correlated with BMI, FBG, HOMA-IR, TG and TC.	Thioguanine	76-78	fibrillin 1	Homo sapiens	16-24
34499590-4	2022	Linear regression was used to examine the association between overall insulin resistance measured by the mean triglyceride to HDL cholesterol ratio (TG:HDL), and change in TG:HDL over time for each participant with echocardiographic RV function.	Thioguanine	149-151	insulin	Homo sapiens	70-77
34462238-6	2021	RESULTS: After GH withdrawal, we found a reduction in fasting plasma TRL concentration (significant decrease in TRL-TG, TRL-cholesterol, TRL-apoB-100, TRL-apoC-III and TRL-apoC-II) but not in postprandial TRL response.	Thioguanine	116-118	growth hormone 1	Homo sapiens	15-17
34252412-5	2021	In male and female hPPARalpha mice, PFOA increased total liver TG and TG substituted with saturated and monounsaturated fatty acids.	Thioguanine	70-72	peroxisome proliferator activated receptor alpha	Homo sapiens	19-29
34252412-7	2021	In hPPARalpha mice, PFOA neither significantly increased nor decreased serum TG; however, there was a modest increase in TG associated with very low-density cholesterol particles in both sexes.	Thioguanine	121-123	peroxisome proliferator activated receptor alpha	Homo sapiens	3-13
34252412-8	2021	Intriguingly, in female PPARalpha null mice, PFOA significantly increased serum TG, with a similar trend in males.	Thioguanine	80-82	peroxisome proliferator activated receptor alpha	Mus musculus	24-33
34252412-9	2021	PFOA also modified fatty acid and TG homeostasis-related gene expression in liver, in a hPPARalpha-dependent manner, but not in adipose.	Thioguanine	34-36	peroxisome proliferator activated receptor alpha	Homo sapiens	88-98
34228493-6	2021	FAN1 also contributes towards MMR in vivo: cells lacking both EXO1 and FAN1 have a MMR defect and display resistance to N-methyl-N-nitrosourea (MNU) and 6-thioguanine (TG).	Thioguanine	153-166	exonuclease 1	Mus musculus	62-66
34228493-6	2021	FAN1 also contributes towards MMR in vivo: cells lacking both EXO1 and FAN1 have a MMR defect and display resistance to N-methyl-N-nitrosourea (MNU) and 6-thioguanine (TG).	Thioguanine	153-166	FANCD2/FANCI-associated nuclease 1	Mus musculus	71-75
34228493-6	2021	FAN1 also contributes towards MMR in vivo: cells lacking both EXO1 and FAN1 have a MMR defect and display resistance to N-methyl-N-nitrosourea (MNU) and 6-thioguanine (TG).	Thioguanine	168-170	FANCD2/FANCI-associated nuclease 1	Mus musculus	0-4
34228493-6	2021	FAN1 also contributes towards MMR in vivo: cells lacking both EXO1 and FAN1 have a MMR defect and display resistance to N-methyl-N-nitrosourea (MNU) and 6-thioguanine (TG).	Thioguanine	168-170	exonuclease 1	Mus musculus	62-66
34228493-6	2021	FAN1 also contributes towards MMR in vivo: cells lacking both EXO1 and FAN1 have a MMR defect and display resistance to N-methyl-N-nitrosourea (MNU) and 6-thioguanine (TG).	Thioguanine	168-170	FANCD2/FANCI-associated nuclease 1	Mus musculus	71-75
34375910-9	2021	Decreased eGFR and presence of proteinuria were independently associated with higher risks for new-onset of High-TG, Low-HDL-C, and High-TG/HDL-C ratios.	Thioguanine	113-115	epidermal growth factor receptor	Homo sapiens	10-14
34375910-9	2021	Decreased eGFR and presence of proteinuria were independently associated with higher risks for new-onset of High-TG, Low-HDL-C, and High-TG/HDL-C ratios.	Thioguanine	137-139	epidermal growth factor receptor	Homo sapiens	10-14
34228493-6	2021	FAN1 also contributes towards MMR in vivo: cells lacking both EXO1 and FAN1 have a MMR defect and display resistance to N-methyl-N-nitrosourea (MNU) and 6-thioguanine (TG).	Thioguanine	153-166	FANCD2/FANCI-associated nuclease 1	Mus musculus	0-4
34330502-2	2021	A high triglyceride to high density lipoprotein cholesterol (Tg/HDL c) ratio has been associated with reduced insulin sensitivity, metabolic syndrome and adverse cardiovascular events.	Thioguanine	61-63	insulin	Homo sapiens	110-117
34490378-2	2021	This study aimed to investigate the effects of the triglyceride to high-density lipid (HDL)-cholesterol ratio (TG/HDL-C), which could reflect insulin resistance from the beginning, on the incident risk of ischemic heart disease (IHD).	Thioguanine	111-113	insulin	Homo sapiens	142-149
34212939-11	2021	Vit E/ (TG+TC) was also significantly lower in diabetics or those with elevated levels of high sensitive C-reactive protein (hs-CRP).	Thioguanine	8-10	vitrin	Homo sapiens	0-3
34165172-11	2021	The present results also revealed that overexpression of Twist1 increased podocyte apoptosis, although this was decreased after TG treatment, indicating that TG may exhibit a protective effect on podocytes by inhibiting the Twist1 signaling pathway.	Thioguanine	128-130	twist family bHLH transcription factor 1	Homo sapiens	224-230
34165172-11	2021	The present results also revealed that overexpression of Twist1 increased podocyte apoptosis, although this was decreased after TG treatment, indicating that TG may exhibit a protective effect on podocytes by inhibiting the Twist1 signaling pathway.	Thioguanine	158-160	twist family bHLH transcription factor 1	Homo sapiens	57-63
34165172-11	2021	The present results also revealed that overexpression of Twist1 increased podocyte apoptosis, although this was decreased after TG treatment, indicating that TG may exhibit a protective effect on podocytes by inhibiting the Twist1 signaling pathway.	Thioguanine	158-160	twist family bHLH transcription factor 1	Homo sapiens	224-230
34361001-6	2021	FliiTg/Tg led to increased symmetrical cell division of EpSCs with increased cell proliferation rate, an elevated epidermal SOX9, Flap1 and beta-cat expression, a thinner epidermis, but increased hair follicle number and depth.	Thioguanine	7-9	SRY (sex determining region Y)-box 9	Mus musculus	124-128
34361001-6	2021	FliiTg/Tg led to increased symmetrical cell division of EpSCs with increased cell proliferation rate, an elevated epidermal SOX9, Flap1 and beta-cat expression, a thinner epidermis, but increased hair follicle number and depth.	Thioguanine	7-9	leucine rich repeat (in FLII) interacting protein 1	Mus musculus	130-135
34361001-6	2021	FliiTg/Tg led to increased symmetrical cell division of EpSCs with increased cell proliferation rate, an elevated epidermal SOX9, Flap1 and beta-cat expression, a thinner epidermis, but increased hair follicle number and depth.	Thioguanine	7-9	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	140-148
34326769-10	2021	It was worth noting that hydroxysteroid 17beta-dehydrogenase 13 (HSD17beta13) as a critical element of increasing blood lipid biomarker-triglyceride (TG), was decreased markedly by DSS.	Thioguanine	150-152	hydroxysteroid (17-beta) dehydrogenase 13	Rattus norvegicus	25-63
34356426-4	2021	It was found that the relaxation of the configurational entropy of MD corresponds to the effective cooling rate of 6.3 x 106 Ks-1 and its extrapolation to 0.33 Ks-1 mimics the glass transition with Tg; close to the experimental value.	Thioguanine	198-200	zinc finger protein 382	Homo sapiens	125-129
34356426-4	2021	It was found that the relaxation of the configurational entropy of MD corresponds to the effective cooling rate of 6.3 x 106 Ks-1 and its extrapolation to 0.33 Ks-1 mimics the glass transition with Tg; close to the experimental value.	Thioguanine	198-200	zinc finger protein 382	Homo sapiens	160-164
34212939-12	2021	Additionally, there was a significant association between Vit E/ (TG + Total Cho) and the number of components of the metabolic syndrome (p= 0.02) Conclusions.	Thioguanine	66-68	vitrin	Homo sapiens	58-61
34212939-14	2021	Moreover, a significantly lower Vit E/ (TC+TG) was observed along with individuals with increasing numbers of components of the MetS.	Thioguanine	43-45	vitrin	Homo sapiens	32-35
34155967-11	2021	Additionally, the (AA+AG) group was significantly related to PUFA intake in terms of MetS (P=0.04), TG (P=0.02), glucose (P=0.02), and HOMA-IR (P= 0.01).	Thioguanine	100-102	pumilio RNA binding family member 3	Homo sapiens	61-65
34198561-2	2021	Thus, we investigated the association of serum ALP level with surrogate markers of insulin resistance such as triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C ratio) and triglyceride and glucose (TyG) index in the general population.	Thioguanine	170-172	alkaline phosphatase, placental	Homo sapiens	47-50
34220941-10	2021	Specific gene variants were associated with altered placental transfer of PFAS (ALAD Lys59Asn, ABCG2 Gln141Lys), THg (UGT Tyr85Asp, GSTT1del, ABCC1 rs246221) and Pb (GSTP1 Ala114Val).	Thioguanine	113-116	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	118-121
34071097-7	2021	(3) Results: RARRES2rs17173608 (TT, TG, and GG polymorphisms in the preliminary analysis; TG and GG polymorphisms in a secondary analysis) was associated with insulin resistance and the severity of CAD in both the preliminary and secondary analysis (all p-values were < 0.05).	Thioguanine	36-38	insulin	Homo sapiens	159-166
34116656-12	2021	Cmap showed that apigenin, thioguanine and trichostatin A might be used to treat CC(P < 0.05).	Thioguanine	27-38	cystatin F	Homo sapiens	0-4
34082596-11	2021	RBC, HGB, HDL values, and HDL/LDL ratio were found to be significantly higher in the HAG (P < 0.001) whereas LDL, TG, and TC values were significantly higher in the SLG (P < 0.001).	Thioguanine	114-116	sialic acid binding Ig like lectin 12	Homo sapiens	165-168
33949005-7	2021	Large scale metabolomic analysis of liver tissue confirms that both methionine and methionine-sulfoxide are significantly more elevated in Tg-G307S Cbs-/- animals, along with significant differences in several other metabolites including hexoses, amino acids, other amines, lipids, and carboxylic acids.	Thioguanine	139-141	cystathionine beta-synthase	Mus musculus	148-151
34071097-7	2021	(3) Results: RARRES2rs17173608 (TT, TG, and GG polymorphisms in the preliminary analysis; TG and GG polymorphisms in a secondary analysis) was associated with insulin resistance and the severity of CAD in both the preliminary and secondary analysis (all p-values were < 0.05).	Thioguanine	90-92	insulin	Homo sapiens	159-166
34177084-10	2021	There is significant negative correlation between insulin resistance and TG level (r2=0.0529, p=0.01).	Thioguanine	73-75	insulin	Homo sapiens	50-57
34074372-15	2021	Adipocyte factor LEP was positively correlated with the content of FBG, TG, TC and LDL-C, with r values of 0.	Thioguanine	72-74	leptin	Mus musculus	17-20
34085012-9	2020	RESULTS: This meta-analysis found that MDM2 309T>G polymorphism was significantly associated with Rb risk in the dominant model, TG+GG versus TT (OR = 1.43, 95% CI = 1.11-1.84, P = 0.006).	Thioguanine	129-131	MDM2 proto-oncogene	Homo sapiens	39-43
34085012-9	2020	RESULTS: This meta-analysis found that MDM2 309T>G polymorphism was significantly associated with Rb risk in the dominant model, TG+GG versus TT (OR = 1.43, 95% CI = 1.11-1.84, P = 0.006).	Thioguanine	129-131	RB transcriptional corepressor 1	Mus musculus	98-100
34064531-5	2021	The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-).	Thioguanine	99-101	tumor necrosis factor	Homo sapiens	33-42
34064531-5	2021	The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-).	Thioguanine	99-101	interleukin 1 alpha	Homo sapiens	44-52
34064531-5	2021	The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-).	Thioguanine	99-101	interleukin 6	Homo sapiens	58-62
34064531-5	2021	The inflammatory adipocytokines, TNF-alpha, IL-1beta, and IL-6, were increased in the salt-treated Tg(+/+) WAT, but an anti-inflammation biomarker, the adiponectin/leptin ratio, was reduced in Tg(+/+), to tenth of that in Tg(-/-).	Thioguanine	193-195	adiponectin, C1Q and collagen domain containing	Homo sapiens	152-163
35472854-3	2022	The SRA-induced flipping of mC was found to strongly increase the fluorescence intensity of thG, but this increase was much larger when thG was flanked in 3" by a C residue as compared to an A residue.	Thioguanine	92-95	macrophage scavenger receptor 1	Homo sapiens	4-7
35591906-2	2022	The four non-insulin-based indexes of insulin resistance (IR) include the glucose and triglycerides index (TyG), TyG index with body mass index (TyG-BMI), ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and metabolic score for insulin resistance (METS-IR).	Thioguanine	219-221	insulin	Homo sapiens	38-45
35524581-4	2022	Hepatocyte-specific deletion of MDM2 protects against high-fat high-cholesterol diet-induced hepatic steatosis and inflammation, accompanied by a significant elevation in TG-VLDL secretion.	Thioguanine	171-173	transformed mouse 3T3 cell double minute 2	Mus musculus	32-36
35524581-4	2022	Hepatocyte-specific deletion of MDM2 protects against high-fat high-cholesterol diet-induced hepatic steatosis and inflammation, accompanied by a significant elevation in TG-VLDL secretion.	Thioguanine	171-173	CD320 antigen	Mus musculus	174-178
35505157-5	2022	In conclusion, HDAC11-AS1 plays an anti-atherogenic role through adropin to induce LPL expressions, thereby enhancing TG metabolism.	Thioguanine	118-120	histone deacetylase 11	Mus musculus	15-21
35505157-5	2022	In conclusion, HDAC11-AS1 plays an anti-atherogenic role through adropin to induce LPL expressions, thereby enhancing TG metabolism.	Thioguanine	118-120	arylsulfatase B	Mus musculus	22-25
35505157-5	2022	In conclusion, HDAC11-AS1 plays an anti-atherogenic role through adropin to induce LPL expressions, thereby enhancing TG metabolism.	Thioguanine	118-120	energy homeostasis associated	Mus musculus	65-72
35472854-2	2022	To fully exploit the information given by the probe, we carefully re-investigated the thG spectroscopic properties in 12-bp duplexes, when the Set and Ring Associated (SRA) domain of UHRF1 flips its 5" flanking methylcytosine (mC).	Thioguanine	86-89	macrophage scavenger receptor 1	Homo sapiens	168-171
35472854-2	2022	To fully exploit the information given by the probe, we carefully re-investigated the thG spectroscopic properties in 12-bp duplexes, when the Set and Ring Associated (SRA) domain of UHRF1 flips its 5" flanking methylcytosine (mC).	Thioguanine	86-89	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	183-188
35472854-3	2022	The SRA-induced flipping of mC was found to strongly increase the fluorescence intensity of thG, but this increase was much larger when thG was flanked in 3" by a C residue as compared to an A residue.	Thioguanine	136-139	macrophage scavenger receptor 1	Homo sapiens	4-7
35472854-4	2022	Surprisingly, the quantum yield and fluorescence lifetime values of thG were nearly constant, regardless of the presence of SRA and the nature of the 3" flanking residue, suggesting that the differences in fluorescence intensities might be related to changes in absorption properties.	Thioguanine	68-71	macrophage scavenger receptor 1	Homo sapiens	124-127
35472854-7	2022	The amplitude of thG red-shifted band strongly increased when its 3" flanking C residue was replaced by an A residue in the free duplex, or when its 5" flanking mC residue was flipped by SRA.	Thioguanine	17-20	macrophage scavenger receptor 1	Homo sapiens	187-190
35472854-8	2022	As only the species associated with the red-shifted band were found to be emissive, the highly unusual finding of this work is that the brightness of thG in free duplexes as well as its changes on SRA-induced mC flipping almost entirely depend on the relative population and/or absorption coefficient of the red-shifted absorbing species.	Thioguanine	150-153	macrophage scavenger receptor 1	Homo sapiens	197-200
35563234-9	2022	Alcohol exposure significantly increased serum levels of TG, ALT, and AST in Elf4-/- mice but not in WT mice.	Thioguanine	57-59	E74-like factor 4 (ets domain transcription factor)	Mus musculus	77-81
35559416-7	2022	The lncRNA NEAT1 expressions in the NAFLD patients presented a remarkable positive correlation with the ALT, GGT, TC, and TG levels (P<0.05).	Thioguanine	122-124	nuclear paraspeckle assembly transcript 1	Homo sapiens	11-16
35189320-6	2022	Significant reduction in plasma TG excursion was observed, thus indicating DGAT1 inhibition in-vivo.	Thioguanine	32-34	diacylglycerol O-acyltransferase 1	Mus musculus	75-80
35516426-4	2022	Here, we show that oral administration of Rb1 significantly decreased serum LDL-c, TG, insulin, and insulin resistance index (HOMA-IR) in mice with a high-fat diet (HFD).	Thioguanine	83-85	RB transcriptional corepressor 1	Mus musculus	42-45
35397046-3	2022	The lowest THg (31.9 microg/kg) and MeHg (0.1 microg/kg) concentrations were found in HSR-1.	Thioguanine	11-14	G protein nucleolar 1 (putative)	Homo sapiens	86-91
35455983-9	2022	(3) Results: The levels of TG in serum and IL-6 protein content in liver tissue in the ALD group were significantly increased compared to the Con group (p < 0.05); compared with ALD, p47phox expression in muscle was increased significantly in the ALD + NOXI group (p < 0.05), and TG in serum decreased in the ALD + Ex group (p < 0.05).	Thioguanine	280-282	neutrophil cytosolic factor 1	Mus musculus	183-190
35351068-8	2022	ApoE rs429358 and rs7412 variants were observed to have the highest serum TC and TG level in the subjects with high serum tHcy level (p <  0.05).	Thioguanine	81-83	apolipoprotein E	Homo sapiens	0-4
35431563-8	2022	Results: Systolic blood pressure (SBP), diabetic retinopathy (DR), hemoglobin (Hb), fasting plasma glucose (FPG) and triglyceride/cystatin C (TG/Cys-C) ratio were independent factors for DN in T2DM patients with proteinuria (P<0.05).	Thioguanine	142-144	cystatin C	Homo sapiens	130-140
35387339-9	2022	The assessment of the association between 6-TG and 6-MMP concentrations with thiopurine S-methyltransferase (TPMT) phenotype and genotype demonstrated a statistically significant difference in the thiopurine metabolite concentrations between the TPMT groups with normal and intermediate activity of 6-MMP (p < 0.0001), while the difference in 6-TG concentrations was statistically not significant (p = 0.096).	Thioguanine	42-46	thiopurine S-methyltransferase	Homo sapiens	77-107
35322811-10	2022	Additionally, we demonstrated that the MGAT activity of DGAT1 only makes a minor contribution to TG synthesis in intact HepG2 cells.	Thioguanine	97-99	diacylglycerol O-acyltransferase 1	Homo sapiens	56-61
35322811-11	2022	Our data demonstrated that the MGAT pathway has a role in hepatic lipid metabolism with MGAT2, more so than MGAT3, contributing to TG synthesis and secretion.	Thioguanine	131-133	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	88-93
35322811-11	2022	Our data demonstrated that the MGAT pathway has a role in hepatic lipid metabolism with MGAT2, more so than MGAT3, contributing to TG synthesis and secretion.	Thioguanine	131-133	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	108-113
35387339-9	2022	The assessment of the association between 6-TG and 6-MMP concentrations with thiopurine S-methyltransferase (TPMT) phenotype and genotype demonstrated a statistically significant difference in the thiopurine metabolite concentrations between the TPMT groups with normal and intermediate activity of 6-MMP (p < 0.0001), while the difference in 6-TG concentrations was statistically not significant (p = 0.096).	Thioguanine	42-46	thiopurine S-methyltransferase	Homo sapiens	109-113
35387339-9	2022	The assessment of the association between 6-TG and 6-MMP concentrations with thiopurine S-methyltransferase (TPMT) phenotype and genotype demonstrated a statistically significant difference in the thiopurine metabolite concentrations between the TPMT groups with normal and intermediate activity of 6-MMP (p < 0.0001), while the difference in 6-TG concentrations was statistically not significant (p = 0.096).	Thioguanine	42-46	thiopurine S-methyltransferase	Homo sapiens	246-250
35387339-9	2022	The assessment of the association between 6-TG and 6-MMP concentrations with thiopurine S-methyltransferase (TPMT) phenotype and genotype demonstrated a statistically significant difference in the thiopurine metabolite concentrations between the TPMT groups with normal and intermediate activity of 6-MMP (p < 0.0001), while the difference in 6-TG concentrations was statistically not significant (p = 0.096).	Thioguanine	343-347	thiopurine S-methyltransferase	Homo sapiens	77-107
35387339-9	2022	The assessment of the association between 6-TG and 6-MMP concentrations with thiopurine S-methyltransferase (TPMT) phenotype and genotype demonstrated a statistically significant difference in the thiopurine metabolite concentrations between the TPMT groups with normal and intermediate activity of 6-MMP (p < 0.0001), while the difference in 6-TG concentrations was statistically not significant (p = 0.096).	Thioguanine	343-347	thiopurine S-methyltransferase	Homo sapiens	109-113
35088229-9	2022	Furthermore, it was discovered that upregulated lnc-HULC was associated with elevated blood lipid levels (TG, LDL-C), inflammatory cytokines (interleukin (IL)-1beta, IL-17A), cell adhesion molecules (VCAM-1), and Gensini score (all P < 0.05) in CHD patients.	Thioguanine	106-108	hepatocellular carcinoma up-regulated long non-coding RNA	Homo sapiens	48-56
35281463-9	2022	As proven by our meta-analysis, TG as adjuvant therapy or monotherapy decreased the BASDAI, BASFI, SP-VAS, serum CRP, and ESR than control in patients suffering from AS.	Thioguanine	32-34	C-reactive protein	Homo sapiens	113-116
35386772-10	2022	When TG levels spiked again, the patient was put on an insulin infusion with heparin, glucose, and potassium to rapidly reduce TG level.	Thioguanine	127-129	insulin	Homo sapiens	55-62
35188037-16	2022	VDBP was higher in women with GT/TG and TT than those with GG, but there was no statistical significance.	Thioguanine	33-35	GC vitamin D binding protein	Homo sapiens	0-4
35368750-9	2022	TG adjuvant MTX also reduced the expression rate of the swollen joint count, tender joint count, erythrocyte sedimentation rate, rheumatoid factor, and C-reactive protein in subgroup analyses with different courses and doses.	Thioguanine	0-2	C-reactive protein	Homo sapiens	152-170
35370951-0	2022	TG: HDL-C Ratio as Insulin Resistance Marker for Metabolic Syndrome in Children With Obesity.	Thioguanine	0-2	insulin	Homo sapiens	19-26
35265126-16	2022	Multiple linear regression analyses of stepwise models implied that TG, LDL-C, and beta-CTX were independently associated with serum irisin concentrations (P < 0.01 or P < 0.05).	Thioguanine	68-70	fibronectin type III domain containing 5	Homo sapiens	133-139
35178098-13	2022	In vitro experiments demonstrated that stigmasterol reduced lipid accumulation and TG levels in HepG2 cells, and the mechanism may have been related to the activation of the PPARgamma-UCP-1 signalling pathway.	Thioguanine	83-85	peroxisome proliferator activated receptor gamma	Homo sapiens	174-183
35178098-13	2022	In vitro experiments demonstrated that stigmasterol reduced lipid accumulation and TG levels in HepG2 cells, and the mechanism may have been related to the activation of the PPARgamma-UCP-1 signalling pathway.	Thioguanine	83-85	uncoupling protein 1	Homo sapiens	184-189
35046484-2	2022	THG are known to suppress Cellular Communication Network factor 1 (CCN1), which regulates collagen homeostasis in the dermis.	Thioguanine	0-3	cellular communication network factor 1	Homo sapiens	26-65
35126125-6	2021	The maximum of TG before insulin treatment was up to 64.62 and TC 20.43 mmol/L, which decreased to 17.34 and 4.92 mmol/L after intervention of the insulin drip.	Thioguanine	15-17	insulin	Homo sapiens	25-32
35126125-10	2021	Conclusion: The use of insulin in the management of gestational hypertriglyceridemia is safe and efficient, and insulin may become a mainstream in the near future to mitigate serum TG and TC levels in the pregnancy period besides regulating the blood glucose level.	Thioguanine	181-183	insulin	Homo sapiens	23-30
35126125-10	2021	Conclusion: The use of insulin in the management of gestational hypertriglyceridemia is safe and efficient, and insulin may become a mainstream in the near future to mitigate serum TG and TC levels in the pregnancy period besides regulating the blood glucose level.	Thioguanine	181-183	insulin	Homo sapiens	112-119
35046484-2	2022	THG are known to suppress Cellular Communication Network factor 1 (CCN1), which regulates collagen homeostasis in the dermis.	Thioguanine	0-3	cellular communication network factor 1	Homo sapiens	67-71
35046484-4	2022	Here we describe a possible mechanism involved in skin aging focusing on the effect of THG on epidermal CCN1.	Thioguanine	87-90	cellular communication network factor 1	Homo sapiens	104-108
35046484-5	2022	This study shows that: (1) THG suppress epidermal CCN1 expression by inhibiting the translocation of Yes-Associated Protein (YAP) to nuclei.	Thioguanine	27-30	cellular communication network factor 1	Homo sapiens	50-54
35046484-5	2022	This study shows that: (1) THG suppress epidermal CCN1 expression by inhibiting the translocation of Yes-Associated Protein (YAP) to nuclei.	Thioguanine	27-30	Yes1 associated transcriptional regulator	Homo sapiens	101-123
35046484-5	2022	This study shows that: (1) THG suppress epidermal CCN1 expression by inhibiting the translocation of Yes-Associated Protein (YAP) to nuclei.	Thioguanine	27-30	Yes1 associated transcriptional regulator	Homo sapiens	125-128
35046484-10	2022	Taken together, THG might be a promising treatment for aged skin by suppressing the aberrant YAP-CCN1 axis.	Thioguanine	16-19	Yes1 associated transcriptional regulator	Homo sapiens	93-96
35046484-10	2022	Taken together, THG might be a promising treatment for aged skin by suppressing the aberrant YAP-CCN1 axis.	Thioguanine	16-19	cellular communication network factor 1	Homo sapiens	97-101
34996463-11	2022	The AUCs (95% confidence interval) were 0.945 (0.884-1.000) for TG/LDL-C ratio and 0.614 (0.463-0.765) for non-HDL-C in patients without statins (P = 0.0002).	Thioguanine	64-66	component of oligomeric golgi complex 2	Homo sapiens	67-72
34996463-12	2022	The AUCs were 0.697 (0.507-0.887) for TG/LDL-C and 0.682 (0.500-0.863) for non-HDL-C in patients treated with statins.	Thioguanine	38-40	component of oligomeric golgi complex 2	Homo sapiens	41-46
34986898-12	2022	Tg-DC-Exo and miR-155-5p stimulated host proinflammatory immune responses including increased production of proinflammatory cytokines IL-6 and TNF-alpha, and proinflammatory marker-inducible nitric oxide synthase (iNOS).	Thioguanine	0-2	5'-3' exoribonuclease 1	Mus musculus	6-9
35111069-6	2021	In comparison to statins, RYR was more effective in lowering TG (MD, -19.90; 95% CI, -32.22 to -7.58; p = 0.002), comparable in lowering LDL-C and elevating HDL-C, and less effective in lowering TC (MD, 12.24; 95% CI, 2.19 to 22.29; p = 0.02).	Thioguanine	61-63	ryanodine receptor 2	Homo sapiens	26-29
35111069-8	2021	Moreover, RYR effectively synergized nutraceutical to further reduce TC (MD, -31.10; 95% CI, -38.83 to -23.36; p < 0.00001), LDL-C (MD, -27.91; 95% CI, -36.58 to -19.24; p < 0.00001), and TG (MD, -26.32; 95% CI, -34.05 to -18.59; p < 0.00001).	Thioguanine	188-190	ryanodine receptor 2	Homo sapiens	10-13
35297474-10	2022	RESULTS: SIRT1 activator negatively regulated the weight and TC, TG and LDL levels, alleviated the lesion conditions and decreased the CD34+/VEGFR2+ density compared to the AS control.	Thioguanine	65-67	sirtuin 1	Mus musculus	9-14
35178989-2	2022	As revealed by the MTT assay, ZXD had no effect on HepG2 activity, but dose-dependently down-regulated alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the liver cell medium induced by PA, and decreased the plasma levels of ALT and AST, and total cholesterol(TC) and triglyceride(TG) levels in the liver.	Thioguanine	300-302	glutamic pyruvic transaminase, soluble	Mus musculus	128-131
35178989-2	2022	As revealed by the MTT assay, ZXD had no effect on HepG2 activity, but dose-dependently down-regulated alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the liver cell medium induced by PA, and decreased the plasma levels of ALT and AST, and total cholesterol(TC) and triglyceride(TG) levels in the liver.	Thioguanine	300-302	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	164-167