PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 19006228-4 2009 NTBI levels correlated with transferrin saturation, age, and ALT, and not with serum ferritin or liver iron concentrations. ntbi 0-4 transferrin Homo sapiens 28-39 19006228-5 2009 At a multiple regression analysis, transferrin saturation and heart disease but not age was independent predictors of NTBI. ntbi 118-122 transferrin Homo sapiens 35-46 19021546-4 2008 In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control. ntbi 53-57 transferrin Homo sapiens 63-74 18304722-0 2008 Changes in non-transferrin-bound iron (NTBI) in pregnant women on iron supplements. ntbi 39-43 transferrin Homo sapiens 15-26 18775775-1 2008 Iron release from intravenous iron formulations can increase both non-transferrin-bound iron (NTBI) and oxidative stress. ntbi 94-98 transferrin Homo sapiens 70-81 18297888-5 2007 In view of the importance of non-transferrin-bound plasma iron (NTBI) in iron toxicity and its rapid cellular uptake, it may play an important role in the harmful effects of iron in infection, and this is illustrated by the infectious complications of parenteral iron therapy in tropical countries. ntbi 64-68 transferrin Homo sapiens 33-44 18524764-3 2008 Expression of HFE decreased both TBI and NTBI uptake. ntbi 41-45 homeostatic iron regulator Homo sapiens 14-17 18524764-2 2008 In this study, we investigated the role of HFE in the regulation of both transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI) uptake in HepG2 cells, a human hepatoma cell line. ntbi 134-138 homeostatic iron regulator Homo sapiens 43-46 18524764-5 2008 Zip14 (Slc39a14) is a metal transporter that mediates NTBI into cells (Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., and Cousins, R. J. ntbi 54-58 solute carrier family 39 member 14 Homo sapiens 0-5 18524764-5 2008 Zip14 (Slc39a14) is a metal transporter that mediates NTBI into cells (Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., and Cousins, R. J. ntbi 54-58 solute carrier family 39 member 14 Homo sapiens 7-15 18524764-12 2008 Knockdown of Zip14 with siRNA abolished the effect of HFE on NTBI uptake. ntbi 61-65 solute carrier family 39 member 14 Homo sapiens 13-18 18524764-12 2008 Knockdown of Zip14 with siRNA abolished the effect of HFE on NTBI uptake. ntbi 61-65 homeostatic iron regulator Homo sapiens 54-57 18524764-14 2008 As in HepG2 cells, HFE expression inhibited NTBI uptake by approximately 50% and decreased Zip14 protein levels. ntbi 44-48 homeostatic iron regulator Homo sapiens 19-22 18347019-1 2008 K562 erythroleukemia cells import non-transferrin-bound iron (NTBI) by an incompletely understood process that requires initial iron reduction. ntbi 62-66 transferrin Homo sapiens 38-49 18254965-2 2008 While most iron circulates in blood as transferrin-bound iron, non-transferrin-bound iron (NTBI) also becomes elevated and contributes to toxicity in the setting of iron overload. ntbi 91-95 transferrin Rattus norvegicus 67-78 18254965-18 2008 Changes in cyclin proteins suggest cell cycle disregulation contributes to tumor promotion by NTBI in this liver cell model. ntbi 94-98 proliferating cell nuclear antigen Homo sapiens 11-17 18673149-1 2008 Plasma non-transferrin bound iron (NTBI) is potentially toxic and contributes to the generation of reactive oxygen species (ROS), consequently leading to tissue damage and organ dysfunction. ntbi 35-39 transferrin Rattus norvegicus 11-22 19734120-3 2008 The NADH-dependent system has been suggested to be involved in non-transferrin-bound iron (NTBI) reduction and uptake. ntbi 91-95 transferrin Homo sapiens 67-78 18274990-3 2008 In thalassemia patients, non transferrin bound iron (NTBI) and free hemoglobin (Hb) are present in plasma and may accelerate atherogenesis, but its progression may be inhibited by iron chelators. ntbi 53-57 transferrin Homo sapiens 29-40 17897073-1 2007 Non-transferrin-bound iron (NTBI) is detectable in plasma of beta-thalassemia patients with transfusional iron overload. ntbi 28-32 transferrin Homo sapiens 4-15 17010049-6 2006 A significant 2-fold elevation of non-transferrin bound iron (NTBI) was observed in thalassaemia relative to SCD. ntbi 62-66 transferrin Homo sapiens 38-49 17504202-3 2007 Non-transferrin bound iron (NTBI) detected in thalassemic plasma is highly toxic and chelatable. ntbi 28-32 transferrin Homo sapiens 4-15 17263669-7 2007 The acute phase reactant, haptoglobin (HP) isoforms, showed an approximate fourfold increase in nTBI versus iTBI. ntbi 96-100 haptoglobin Homo sapiens 26-37 17263669-8 2007 In contrast, the levels of prostaglandin D(2) synthase (PGDS) and cystatin C (CC) were 12-fold and sevenfold higher in iTBI versus nTBI, respectively. ntbi 131-135 prostaglandin D2 synthase Homo sapiens 27-54 17263669-8 2007 In contrast, the levels of prostaglandin D(2) synthase (PGDS) and cystatin C (CC) were 12-fold and sevenfold higher in iTBI versus nTBI, respectively. ntbi 131-135 prostaglandin D2 synthase Homo sapiens 56-60 17263669-8 2007 In contrast, the levels of prostaglandin D(2) synthase (PGDS) and cystatin C (CC) were 12-fold and sevenfold higher in iTBI versus nTBI, respectively. ntbi 131-135 cystatin C Homo sapiens 66-76 17263671-5 2007 Victims of inflicted (iTBI) and non-inflicted TBI (nTBI) showed similar (>10-fold) increases in both NSE and S100B versus control. ntbi 51-55 enolase 2 Homo sapiens 104-107 17263671-5 2007 Victims of inflicted (iTBI) and non-inflicted TBI (nTBI) showed similar (>10-fold) increases in both NSE and S100B versus control. ntbi 51-55 S100 calcium binding protein B Homo sapiens 112-117 17263673-8 2007 Significant between-group differences (iTBI vs. nTBI) were found for time to peak NSE (66.48 +/- 53.56 vs.8.11 +/- 11.58), S100B (43.30 +/- 51.41 vs. 8.21 +/- 8.29), and MBP (77.66 +/- 56.77 vs. 21.63 +/- 28.39). ntbi 48-52 enolase 2 Homo sapiens 82-85 17263673-8 2007 Significant between-group differences (iTBI vs. nTBI) were found for time to peak NSE (66.48 +/- 53.56 vs.8.11 +/- 11.58), S100B (43.30 +/- 51.41 vs. 8.21 +/- 8.29), and MBP (77.66 +/- 56.77 vs. 21.63 +/- 28.39). ntbi 48-52 S100 calcium binding protein B Homo sapiens 123-128 17263673-8 2007 Significant between-group differences (iTBI vs. nTBI) were found for time to peak NSE (66.48 +/- 53.56 vs.8.11 +/- 11.58), S100B (43.30 +/- 51.41 vs. 8.21 +/- 8.29), and MBP (77.66 +/- 56.77 vs. 21.63 +/- 28.39). ntbi 48-52 myelin basic protein Homo sapiens 170-173 16950869-4 2006 We analyzed the capability of Zip14 to mediate non-transferrin-bound iron (NTBI) uptake by overexpressing mouse Zip14 in HEK 293H cells and Sf9 insect cells. ntbi 75-79 solute carrier family 39 (zinc transporter), member 14 Mus musculus 30-35 16950869-10 2006 Collectively, these results indicate that Zip14 can mediate the uptake of zinc and NTBI into cells and that it may play a role in zinc and iron metabolism in hepatocytes, where this transporter is abundantly expressed. ntbi 83-87 solute carrier family 39 member 14 Homo sapiens 42-47 16950869-11 2006 Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases. ntbi 8-12 solute carrier family 39 member 14 Homo sapiens 107-112 16950869-11 2006 Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases. ntbi 122-126 solute carrier family 39 member 14 Homo sapiens 107-112 16644642-6 2006 Serum total iron or percent transferrin saturation were very similar among the three groups, yet NTBI was strongly associated with serum total iron (r = 0.74, P < 0.01) and percent transferrin saturation (r = 0.70, P < 0.01) among the patients with known diabetes. ntbi 97-101 transferrin Homo sapiens 184-195 16707273-1 2006 Non-transferrin bound iron (NTBI) in serum is cleared rapidly by hepatocytes, although the mechanisms of NTBI uptake by hepatocytes are poorly understood. ntbi 28-32 transferrin Homo sapiens 4-15 16707273-8 2006 These results indicate that the DMT1 plays an important role in transporting NTBI into cells. ntbi 77-81 solute carrier family 11 member 2 Homo sapiens 32-36 16682004-1 2006 UNLABELLED: Non-transferrin-bound iron (NTBI) is implicated in lipid peroxidation but the relation with oxidative modification of low-density lipoprotein (LDL) is not known. ntbi 40-44 transferrin Homo sapiens 16-27 16460863-1 2006 BACKGROUND: Under conditions of iron overload non-transferrin-bound iron (NTBI) occurs in the circulation and is mainly cleared by the liver. ntbi 74-78 transferrin Rattus norvegicus 50-61 16460863-8 2006 NTBI uptake was specific for iron, partly inhibited by gallium citrate, diferric transferrin and completely inhibited by apotransferrin in control and gallium-treated cells. ntbi 0-4 transferrin Rattus norvegicus 81-92 16460863-9 2006 In iron-loaded cells, inhibition of NTBI uptake by diferric transferrin completely disappeared within 2 hours. ntbi 36-40 transferrin Rattus norvegicus 60-71 16368718-4 2006 Measured by a recently developed high-throughput fluorescence-based assay, serum NTBI was found to be higher in both homozygotes of HFE C282Y mutation of hereditary hemochromatosis (7.9+/-0.6 microM, n=9, P<0.001) and heterozygotes (4.0+/-0.5 microM, n=8, P<0.001), compared with controls (1.6+/-0.2 microM, n=21). ntbi 81-85 homeostatic iron regulator Homo sapiens 132-135 16618820-2 2006 We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might be more suitable for establishing correlations with CHD. ntbi 89-93 transferrin Homo sapiens 65-76 16368718-7 2006 For the three groups combined, the expression of adhesion molecules, ICAM-1, VCAM-1, and E-selectin, was positively correlated to NTBI levels but not to the inflammatory marker C-reactive protein. ntbi 130-134 intercellular adhesion molecule 1 Homo sapiens 69-75 16368718-7 2006 For the three groups combined, the expression of adhesion molecules, ICAM-1, VCAM-1, and E-selectin, was positively correlated to NTBI levels but not to the inflammatory marker C-reactive protein. ntbi 130-134 vascular cell adhesion molecule 1 Homo sapiens 77-83 16368718-7 2006 For the three groups combined, the expression of adhesion molecules, ICAM-1, VCAM-1, and E-selectin, was positively correlated to NTBI levels but not to the inflammatory marker C-reactive protein. ntbi 130-134 selectin E Homo sapiens 89-99 15979061-1 2005 BACKGROUND: Non-transferrin bound iron (NTBI) has been found to be raised in end stage renal disease (ESRD) patients on hemodialysis (HD) receiving intravenous (IV) iron. ntbi 40-44 transferrin Homo sapiens 16-27 16809897-2 2006 The purpose of this study was to determine if S. aureus growth is enhanced after administration of IV iron sucrose and to establish a relationship between the appearance of non-transferrin-bound iron (NTBI) and S. aureus growth. ntbi 201-205 transferrin Homo sapiens 177-188 16809897-8 2006 NTBI was present more frequently in patients with baseline transferrin saturation values >30% (p < 0.05). ntbi 0-4 transferrin Homo sapiens 59-70 16943655-6 2006 Initial NSE concentration was highest after nTBI. ntbi 44-48 enolase 2 Homo sapiens 8-11 16540419-3 2006 In humans, iron-deficiency results in anemia, while excess iron can lead to organ damage as a result of a build-up of non-transferrin-bound iron (NTBI). ntbi 146-150 transferrin Homo sapiens 122-133 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. ntbi 120-124 RoBo-1 Rattus norvegicus 0-28 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. ntbi 120-124 RoBo-1 Rattus norvegicus 30-34 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. ntbi 120-124 transferrin receptor Rattus norvegicus 40-60 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. ntbi 120-124 transferrin receptor Rattus norvegicus 62-65 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. ntbi 120-124 transferrin Rattus norvegicus 40-51 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. ntbi 120-124 transferrin Rattus norvegicus 96-107 16137791-2 2005 Recent studies demonstrated that nerve growth factor (NGF)-treated PC12 cells (the neuronal phenotype) have higher NTBI as well as Tf-Fe uptake compared with untreated cells (the undifferentiated cells). ntbi 115-119 nerve growth factor Rattus norvegicus 33-52 16137791-2 2005 Recent studies demonstrated that nerve growth factor (NGF)-treated PC12 cells (the neuronal phenotype) have higher NTBI as well as Tf-Fe uptake compared with untreated cells (the undifferentiated cells). ntbi 115-119 nerve growth factor Rattus norvegicus 54-57 16137791-3 2005 We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR. ntbi 28-32 nerve growth factor Rattus norvegicus 61-64 16137791-3 2005 We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR. ntbi 28-32 RoBo-1 Rattus norvegicus 128-132 16137791-3 2005 We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR. ntbi 28-32 transferrin receptor Rattus norvegicus 137-140 16122007-12 2005 CONCLUSIONS: Serum NSE, S100B, or myelin basic protein are increased in the majority of children with acute nTBI and iTBI, including well-appearing children with iTBI in whom the diagnosis might otherwise have been missed. ntbi 108-112 enolase 2 Homo sapiens 19-22 16085060-6 2005 In turn, Al did induce upregulation of non-Tf bound Fe (NTBI) uptake. ntbi 56-60 transferrin Homo sapiens 43-45 15671444-1 2005 Labile plasma iron (LPI) represents the redox active component of non-transferrin-bound iron (NTBI). ntbi 94-98 transferrin Homo sapiens 70-81 15907869-1 2005 Non-transferrin-bound iron (NTBI) appears in the circulation of patients with iron overload. ntbi 28-32 transferrin Homo sapiens 4-15 15737890-1 2005 Labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox-active and chelatable, capable of permeating into organs and inducing tissue iron overload. ntbi 79-83 transferrin Homo sapiens 55-66 15389541-0 2005 Mouse HFE inhibits Tf-uptake and iron accumulation but induces non-transferrin bound iron (NTBI)-uptake in transformed mouse fibroblasts. ntbi 91-95 homeostatic iron regulator Mus musculus 6-9 12791678-3 2003 HBE cells that constitutively express AE2 mRNA by reverse transcriptase-polymerase chain reaction and AE2 protein by Western analysis avidly transported NTBI after exposure to either Fe2+ or Fe3+, but reduction of Fe3+ to Fe2+ was first required. ntbi 153-157 solute carrier family 4 member 2 Homo sapiens 38-41 14640978-1 2004 Cells take up transferrin-bound iron or NTBI (non-transferrin-bound iron). ntbi 40-44 transferrin Rattus norvegicus 50-61 14640978-2 2004 After treatment with NGF (nerve growth factor), PC12 cells exhibited a neuronal phenotype and an increase in the NTBI uptake (55Fe2+ or 55Fe3+). ntbi 113-117 nerve growth factor Rattus norvegicus 21-24 14640978-2 2004 After treatment with NGF (nerve growth factor), PC12 cells exhibited a neuronal phenotype and an increase in the NTBI uptake (55Fe2+ or 55Fe3+). ntbi 113-117 nerve growth factor Rattus norvegicus 26-45 14640978-4 2004 When examined using calcein fluorescence or radioactive iron, DAG (diacylglycerol)-stimulated NTBI entry was more in NGF-treated PC12 cells compared with untreated cells. ntbi 94-98 nerve growth factor Rattus norvegicus 117-120 14640978-8 2004 To verify that increased NTBI uptake depended on TRPC6, we examined whether transfecting HEK-293 (human embryonic kidney 293) cells with TRPC6 also increased the NTBI (55Fe) uptake. ntbi 162-166 transient receptor potential cation channel subfamily C member 6 Homo sapiens 137-142 14640978-11 2004 However, when iron (Fe2+ and Fe3+) was added before adding phenylephrine or DAG, the fluorescence intensity decreased more rapidly in transfected cells compared with untransfected cells, thereby indicating a greater stimulation of the NTBI uptake in cells expressing TRPC6. ntbi 235-239 transient receptor potential cation channel, subfamily C, member 6 Rattus norvegicus 267-272 14640978-12 2004 We postulate that the increase in the NTBI entry into neuronal PC12 cells is through TRPC6, a pathway that is unique since it is receptor-stimulated. ntbi 38-42 transient receptor potential cation channel, subfamily C, member 6 Rattus norvegicus 85-90 12791678-2 2003 We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-reductase activity involving anion exchange protein 2 (AE2) and extracellular bicarbonate (HCO3-). ntbi 104-108 transferrin Homo sapiens 80-91 12791678-2 2003 We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-reductase activity involving anion exchange protein 2 (AE2) and extracellular bicarbonate (HCO3-). ntbi 104-108 solute carrier family 4 member 2 Homo sapiens 172-196 12791678-2 2003 We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-reductase activity involving anion exchange protein 2 (AE2) and extracellular bicarbonate (HCO3-). ntbi 104-108 solute carrier family 4 member 2 Homo sapiens 198-201 15543932-1 2004 Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR) through iron-regulatory mRNA-binding proteins (IRPs), and may additionally regulate uptake and accumulation of non-transferrin-bound iron (NTBI). ntbi 292-296 transferrin receptor Homo sapiens 148-151 15321958-1 2004 OBJECTIVE: To confirm the increase in non-transferrin bound iron (NTBI) after packed red cell (PRC) transfusion and to evaluate the association with increased oxidative stress in preterm infants. ntbi 66-70 transferrin Homo sapiens 42-53 15155457-4 2004 Plasma NTBI levels were increased 2.5-fold in Hfe knockout mice compared with control mice. ntbi 7-11 homeostatic iron regulator Mus musculus 46-49 15155457-9 2004 We conclude that NTBI uptake by hepatocytes from Hfe knockout mice contributed to hepatic iron loading. ntbi 17-21 homeostatic iron regulator Mus musculus 49-52 15155457-11 2004 Inhibition of uptake by divalent metals and up-regulation of DMT1 expression suggested that NTBI uptake was mediated by DMT1. ntbi 92-96 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus 61-65 15155457-11 2004 Inhibition of uptake by divalent metals and up-regulation of DMT1 expression suggested that NTBI uptake was mediated by DMT1. ntbi 92-96 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus 120-124 12791678-3 2003 HBE cells that constitutively express AE2 mRNA by reverse transcriptase-polymerase chain reaction and AE2 protein by Western analysis avidly transported NTBI after exposure to either Fe2+ or Fe3+, but reduction of Fe3+ to Fe2+ was first required. ntbi 153-157 solute carrier family 4 member 2 Homo sapiens 102-105 12791678-7 2003 We thus disclose a novel ferri-reductase mechanism of NTBI uptake by human lung cells that employs superoxide exchange for HCO3- by AE2 protein in the plasma membrane. ntbi 54-58 solute carrier family 4 member 2 Homo sapiens 132-135 12805056-1 2003 Plasma non-transferrin-bound-iron (NTBI) is believed to be responsible for catalyzing the formation of reactive radicals in the circulation of iron overloaded subjects, resulting in accumulation of oxidation products. ntbi 35-39 transferrin Homo sapiens 11-22 12767048-2 2003 NTBI uptake by heart cells might be mediated by divalent metal transporter 1 (DMT1). ntbi 0-4 RoBo-1 Rattus norvegicus 48-76 12767048-2 2003 NTBI uptake by heart cells might be mediated by divalent metal transporter 1 (DMT1). ntbi 0-4 RoBo-1 Rattus norvegicus 78-82 12522003-5 2003 IFN-gamma and LPS dose-dependently increased the cellular expression of divalent metal transporter-1, a transmembrane transporter of ferrous iron, and stimulated the uptake of nontransferrin bound iron (NTBI) into cells. ntbi 203-207 interferon gamma Homo sapiens 0-9 12522003-8 2003 Our results demonstrate that the proinflammatory stimuli IFN-gamma and LPS increase the uptake of NTBI via stimulation of divalent metal transporter-1 expression and cause retention of the metal within monocytes by down-regulating ferroportin synthesis. ntbi 98-102 interferon gamma Homo sapiens 57-66 12406099-1 2002 Myeloablative treatment results in iron accumulation and the appearance of non-transferrin-bound iron (NTBI) in the circulation, which may contribute to treatment-related organ damage and susceptibility to infections. ntbi 103-107 transferrin Homo sapiens 79-90 11826241-16 2002 After nTBI, a transient peak in NSE was seen at a median of 11 hours after injury (range: 5-20 hours). ntbi 6-10 enolase 2 Homo sapiens 32-35 11805012-9 2002 In patient samples, NTBI exceeded the detection limits only when transferrin saturation was >80%. ntbi 20-24 transferrin Homo sapiens 65-76 11952985-1 2002 BACKGROUND AND OBJECTIVES: Non-transferrin bound iron (NTBI) is associated with increased morbidity in a number of transfusion-dependent disease states such as the severe haemoglobinopathies. ntbi 55-59 transferrin Homo sapiens 31-42 11826241-18 2002 The magnitude of peak NSE was similar in nTBI and iTBI. ntbi 41-45 enolase 2 Homo sapiens 22-25 11826241-21 2002 S100B showed a single peak at 27 hours (range: 5-63 hours) after both nTBI and iTBI. ntbi 70-74 S100 calcium binding protein B Homo sapiens 0-5 11826241-26 2002 NSE and S100B may also be useful as markers to identify occult iTBI, help differentiate nTBI and iTBI, and assist in determining the time of injury in cases of iTBI. ntbi 88-92 enolase 2 Homo sapiens 0-3 11380478-1 2001 Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. ntbi 68-72 transferrin Homo sapiens 44-55 11730343-1 2001 We introduce a method for monitoring non-transferrin-bound iron (NTBI), a labile and potentially toxic form of serum iron associated with imbalanced iron metabolism. ntbi 65-69 transferrin Homo sapiens 41-52 11564086-2 2001 Excessive transfusions may lead high non-transferrin-bound iron (NTBI). ntbi 65-69 transferrin Homo sapiens 41-52 11380478-2 2001 The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. The transferrin saturation reached 99% on d -4 and remained > 80% thereafter. ntbi 18-22 transferrin Homo sapiens 114-125 11380478-4 2001 High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. ntbi 74-78 transferrin Homo sapiens 5-16 11157499-1 2001 This study introduces a method for monitoring a component of serum non-transferrin-bound iron (NTBI), termed "desferrioxamine-chelatable iron" (DCI). ntbi 95-99 transferrin Homo sapiens 71-82 10029292-2 1999 Non-transferrin-bound iron (NTBI) has been described in most forms of iron overload, but has not been studied in African dietary iron overload. ntbi 28-32 transferrin Homo sapiens 4-15 11099894-1 2000 The concept of non-transferrin bound iron (NTBI) was introduced 22 years ago by Hershko et al. ntbi 43-47 transferrin Homo sapiens 19-30 11099894-6 2000 In accordance with this assumption, NTBI was initially looked for and detected in patients with > or = 100% Tf-saturation. ntbi 36-40 transferrin Homo sapiens 111-113 11099894-7 2000 As techniques for its detection became more sophisticated and sensitive, NTBI was also found in conditions where Tf was not fully saturated, leading to a revision of the original view of NTBI as a simple spillover phenomenon. ntbi 73-77 transferrin Homo sapiens 113-115 10692002-4 2000 In iron overload conditions, non-transferrin-bound iron (NTBI) is found in serum, which can catalyze lipid peroxidation. ntbi 57-61 transferrin Homo sapiens 33-44 10469492-1 1999 Non-transferrin-bound iron (NTBI) has been reported to be associated with several clinical states such as thalassemia, hemochromatosis, and in patients receiving chemotherapy. ntbi 28-32 transferrin Homo sapiens 4-15 9989781-10 1999 Concentration dependence revealed that NTBI uptake into cells, cytosol, stroma, and the nonheme fraction had an apparent low affinity for iron; heme incorporation behaved like a high-affinity process, as did an expression assay for DMT1. ntbi 39-43 solute carrier family 11 member 2 Rattus norvegicus 232-236 9989781-11 1999 DMT1 serves in both apparent high-affinity NTBI membrane transport and the exit of iron from the endosome during Tf delivery of iron in rat reticulocytes; the low-affinity membrane transporter, however, exhibits little dependence on DMT1. ntbi 43-47 solute carrier family 11 member 2 Rattus norvegicus 0-4 10906140-1 2000 Non-transferrin-bound iron (NTBI) uptake has been reported to follow two pathways, Ca(2+)-dependent and Ca(2+)-independent (Wright, T. L., Brissot, P., Ma, W. L., and Weisiger, R. A. ntbi 28-32 transferrin Rattus norvegicus 4-15 10444519-11 1999 Coexposure to TNF-alpha and NTBI, but not to TBI, induced MDA accumulation and greater cytotoxicity (MTT and lactate dehydrogenase release) than TNF-alpha alone. ntbi 28-32 tumor necrosis factor Homo sapiens 145-154 10444519-12 1999 These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis. ntbi 122-126 tumor necrosis factor Homo sapiens 29-38 10444519-12 1999 These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis. ntbi 122-126 interleukin 1 beta Homo sapiens 43-51 17312669-2 1999 Since desferrioxamine administration attenuates this syndrome, non-transferrin-bound-iron (NTBI) released into the perfusing medium during CABG was implicated as a catalyst for oxygen radical formation. ntbi 91-95 transferrin Homo sapiens 67-78 17312675-2 1999 When blood circulates through the fibers having pores with 30 kD cut-off, non-transferrin-bound-iron (NTBI) crosses the fiber pores and is chelated by the immobilized desferrioxamine. ntbi 102-106 transferrin Homo sapiens 78-89 9252093-1 1997 BACKGROUND/AIMS: It is well documented that levels of plasma non-transferrin-bound iron (NTBI), a particularly toxic form of iron, are increased in iron overload disorders. ntbi 89-93 transferrin Rattus norvegicus 65-76 9375751-1 1997 Previous studies have suggested that non-transferrin-bound plasma iron (NTBI) is present in patients undergoing cytotoxic chemotherapy, and that this may exacerbate untoward organ damage and increase the risk of bacterial infections following chemotherapy. ntbi 72-76 transferrin Homo sapiens 41-52 9375751-6 1997 The appearance of NTBI was associated with a sudden rise in transferrin saturation, but NTBI was detected on four occasions in the absence of full transferrin saturation. ntbi 18-22 transferrin Homo sapiens 60-71 9375751-9 1997 The appearance of NTBI following chemotherapy was inverserely related to the fall in reticulocytes and serum transferrin receptor (TfR) levels, suggesting that NTBI formation is a consequence of suspension of erythropoietic activity. ntbi 18-22 transferrin receptor Homo sapiens 109-129 9375751-9 1997 The appearance of NTBI following chemotherapy was inverserely related to the fall in reticulocytes and serum transferrin receptor (TfR) levels, suggesting that NTBI formation is a consequence of suspension of erythropoietic activity. ntbi 18-22 transferrin receptor Homo sapiens 131-134 9375751-9 1997 The appearance of NTBI following chemotherapy was inverserely related to the fall in reticulocytes and serum transferrin receptor (TfR) levels, suggesting that NTBI formation is a consequence of suspension of erythropoietic activity. ntbi 160-164 transferrin receptor Homo sapiens 109-129 9375751-9 1997 The appearance of NTBI following chemotherapy was inverserely related to the fall in reticulocytes and serum transferrin receptor (TfR) levels, suggesting that NTBI formation is a consequence of suspension of erythropoietic activity. ntbi 160-164 transferrin receptor Homo sapiens 131-134 7485509-1 1995 Non-transferrin-bound iron (NTBI) plays an important role in the hepatocellular injury induced by iron overload. ntbi 28-32 transferrin Rattus norvegicus 4-15 9185768-1 1997 In iron overload, non-transferrin-bound iron (NTBI) is found in plasma and is rapidly removed by hepatocytes. ntbi 46-50 transferrin Rattus norvegicus 22-33 9185768-8 1997 The results show that in healthy (recipient) rats, duodenal infusion of 55Fe from NTBI was followed by increased plasma 55Fe when transferrin was unsaturated, or by biliary excretion of 55Fe when transferrin was saturated, indicating intestinal absorption of 55Fe. ntbi 82-86 transferrin Rattus norvegicus 130-141 9185768-8 1997 The results show that in healthy (recipient) rats, duodenal infusion of 55Fe from NTBI was followed by increased plasma 55Fe when transferrin was unsaturated, or by biliary excretion of 55Fe when transferrin was saturated, indicating intestinal absorption of 55Fe. ntbi 82-86 transferrin Rattus norvegicus 196-207 7773198-1 1995 A simple method for direct quantitation of non-transferrin-bound iron (NTBI) in serum is introduced. ntbi 71-75 transferrin Homo sapiens 47-58 34302234-2 2021 Iron surplus load to increase non-transferrin bound iron (NTBI), and NTBI promotes cancer progression and influences microbiota. ntbi 58-62 transferrin Homo sapiens 34-45 8206903-1 1994 Non-transferrin-bound iron (NTBI) uptake occurs in a variety of cells by a saturable, specific and temperature-sensitive process. ntbi 28-32 transferrin Homo sapiens 4-15 8027374-1 1994 AIMS: To investigate and characterise the appearance of non-transferrin bound iron (NTBI) in the serum of patients after cytotoxic chemotherapy and to compare this with the onset and duration of neutropenia. ntbi 84-88 transferrin Homo sapiens 60-71 8320489-3 1993 Fe loading with low-molecular-weight Fe (ferric ammonium citrate) promoted a dose- and time-dependent increase in the rate of uptake of non-transferrin-bound Fe (NTBI) that was positively correlated (R = 0.9, p < 0.005) with cellular iron content. ntbi 162-166 transferrin Homo sapiens 140-151 1419825-1 1992 Non-transferrin-bound iron (NTBI) in plasma is toxic due to its ability to participate in free radical formation with resultant peroxidation and damage to cell membranes and other biomolecules. ntbi 28-32 transferrin Homo sapiens 4-15 1419825-6 1992 The NTBI correlated significantly with serum ferritin (r = 0.467, P < 0.001), total serum iron (r = 0.608, P < 0.001) and transferrin saturation (r = 0.481, P < 0.005). ntbi 4-8 transferrin Homo sapiens 128-139 34637551-1 2022 Non-transferrin bound iron (NTBI) has been classically used to denote a potentially toxic component of plasma detected in systemic iron overload and implicated in end-organ iron accumulation and biological damage. ntbi 28-32 transferrin Homo sapiens 4-15 34801431-3 2022 When iron loading exceeds transferrin binding capacity, labile, non-transferrin-bound iron (NTBI) appears and causes organ injury. ntbi 92-96 transferrin Homo sapiens 26-37 34801431-3 2022 When iron loading exceeds transferrin binding capacity, labile, non-transferrin-bound iron (NTBI) appears and causes organ injury. ntbi 92-96 transferrin Homo sapiens 68-79 34726258-1 2022 Transfusion of storage-damaged red blood cells (RBCs) increases non-transferrin-bound iron (NTBI) levels in humans. ntbi 92-96 transferrin Homo sapiens 68-79 3792614-1 1986 Nontransferrin-bound iron (NTBI) was separated from transferrin bound iron (TBI) by DEAE-Sephadex-CDS filtration. ntbi 27-31 transferrin Homo sapiens 3-14 34204310-1 2021 OBJECTIVE: The aim of this study was to evaluate non-transferrin-bound iron (NTBI) and labile plasma iron (LPI) levels and other parameters of iron metabolism in children undergoing therapy for acute leukemia or after hematopoietic cell transplantation (HCT), in the context of iron overload. ntbi 77-81 transferrin Homo sapiens 53-64 35487763-1 2022 Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. ntbi 171-175 RoBo-1 Rattus norvegicus 59-63 35487763-1 2022 Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. ntbi 171-175 RoBo-1 Rattus norvegicus 108-112 35487763-1 2022 Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. ntbi 171-175 transferrin Rattus norvegicus 147-158 35487763-3 2022 These findings led us to hypothesize that the LVDCC blocker-induced reduction in NTBI uptake might result not only from the inhibition of LVDCC-mediated NTBI uptake but also from the suppression of DMT1-mediated NTBI uptake. ntbi 81-85 RoBo-1 Rattus norvegicus 198-202 35487763-3 2022 These findings led us to hypothesize that the LVDCC blocker-induced reduction in NTBI uptake might result not only from the inhibition of LVDCC-mediated NTBI uptake but also from the suppression of DMT1-mediated NTBI uptake. ntbi 212-216 RoBo-1 Rattus norvegicus 198-202 35487763-6 2022 Our findings imply that the verapamil-induced reduction in NTBI uptake by H9C2 cells is not associated with DMT1 and also indicate that verapamil stimulates rather than inhibits DMT1 expression and DMT1-mediated iron uptake by heart cells. ntbi 59-63 RoBo-1 Rattus norvegicus 178-182 35487763-6 2022 Our findings imply that the verapamil-induced reduction in NTBI uptake by H9C2 cells is not associated with DMT1 and also indicate that verapamil stimulates rather than inhibits DMT1 expression and DMT1-mediated iron uptake by heart cells. ntbi 59-63 RoBo-1 Rattus norvegicus 198-202 35294743-1 2022 Plasma non-transferrin-bound iron (NTBI) exists when the plasma iron content exceeds the carrying capacity of transferrin and can be quickly cleared by the liver, pancreas, and other organs. ntbi 35-39 transferrin Mus musculus 11-22 35294743-1 2022 Plasma non-transferrin-bound iron (NTBI) exists when the plasma iron content exceeds the carrying capacity of transferrin and can be quickly cleared by the liver, pancreas, and other organs. ntbi 35-39 transferrin Mus musculus 110-121 35294743-10 2022 Determination of 7 cytokines in the duodenum were further conducted, which demonstrated that the anti-inflammatory factors interferon (IL)-4 and IL-10 in the duodenum were significantly decreased after NTBI uptake. ntbi 202-206 interleukin 4 Mus musculus 123-140 35294743-10 2022 Determination of 7 cytokines in the duodenum were further conducted, which demonstrated that the anti-inflammatory factors interferon (IL)-4 and IL-10 in the duodenum were significantly decreased after NTBI uptake. ntbi 202-206 interleukin 10 Mus musculus 145-150 35335148-2 2022 However, in several diseases and clinical conditions, hazardous non-transferrin-bound iron (NTBI) species occur. ntbi 92-96 transferrin Homo sapiens 68-79 35335148-8 2022 The currently accepted hypotheses suggest that NTBI is mostly iron bound to citric acid and iron bound to serum albumin, but the chemistry of this system remains fuzzy. ntbi 47-51 albumin Homo sapiens 106-119 3083076-1 1986 Non-transferrin-bound iron (NTBI), a potentially toxic compound, is increased in the serum of patients with iron overload and fully saturated transferrin. ntbi 28-32 transferrin Homo sapiens 4-15 3083076-1 1986 Non-transferrin-bound iron (NTBI), a potentially toxic compound, is increased in the serum of patients with iron overload and fully saturated transferrin. ntbi 28-32 transferrin Homo sapiens 142-153 34480898-2 2021 However, in conditions of iron overload when the iron-binding capacity of transferrin is exceeded, non-transferrin-bound iron (NTBI) appears in plasma. ntbi 127-131 transferrin Homo sapiens 74-85 34480898-2 2021 However, in conditions of iron overload when the iron-binding capacity of transferrin is exceeded, non-transferrin-bound iron (NTBI) appears in plasma. ntbi 127-131 transferrin Homo sapiens 103-114 34480898-5 2021 We modeled in vitro the effects of systemic iron overload on endothelial cells by treating primary human umbilical vein endothelial cells (HUVECs) with NTBI (ferric ammonium citrate, FAC). ntbi 152-156 FA complementation group C Homo sapiens 183-186 35398023-1 2022 Non-transferrin-bound iron (NTBI) is an important biomarker related to the iron loading status of patients with certain diseases. ntbi 28-32 transferrin Homo sapiens 4-15 32115591-1 2020 A novel, micelle-based fluorescence system capable of selective and sensitive signal transduction for non-transferrin-bound iron (NTBI) in serum was devised. ntbi 130-134 transferrin Homo sapiens 106-117 33038380-11 2020 SIGNIFICANCE: Prolactin can be used peripherally and centrally, and exerts its neuro regenerative effects against further damage post-TBI and NTBI. ntbi 142-146 prolactin Homo sapiens 14-23 30903157-6 2020 NTBI causes iron overload, induces reactive oxygen species production and apoptosis in cultured vascular cells, and stimulates massive MCP-1-mediated monocyte recruitment, well-established mechanisms contributing to atherosclerosis. ntbi 0-4 mast cell protease 1 Mus musculus 135-140 30903157-7 2020 NTBI-mediated toxicity is prevented by transferrin- or chelator-mediated iron scavenging. ntbi 0-4 transferrin Mus musculus 39-50 33607814-2 2021 Under iron overload, labile free non-transferrin-bound iron (NTBI) can induce cardiovascular damage with increased oxidative stress. ntbi 61-65 transferrin Homo sapiens 37-48 33607814-7 2021 d-ROM and BNP showed significant trends across NTBI quartiles. ntbi 47-51 natriuretic peptide B Homo sapiens 10-13 33607814-9 2021 In logistic regression analysis, NTBI was independently associated with a combination of higher levels of both d-ROM and BNP than the upper quartiles after adjustment for possible confounding factors.Serum NTBI concentration is detectable in the general population and shows significant inverse associations with oxidative stress and cardiac load. ntbi 33-37 natriuretic peptide B Homo sapiens 121-124 33607814-9 2021 In logistic regression analysis, NTBI was independently associated with a combination of higher levels of both d-ROM and BNP than the upper quartiles after adjustment for possible confounding factors.Serum NTBI concentration is detectable in the general population and shows significant inverse associations with oxidative stress and cardiac load. ntbi 206-210 natriuretic peptide B Homo sapiens 121-124 31434871-4 2019 Herein, we investigated the cellular response of p53-inactivated and telomerase-expressing (immortalized) FTSECs (Pax8+/FoxJ1-) to NTBI (presented as ferric ammonium citrate (FAC), supplemented in media for >2 months) in order to assess its ability to promote the transition to a tumor-like phenotype; this cellular response was compared with immortalized FTSECs transformed with H-RasV12A and c-MycT58A. ntbi 131-135 paired box 8 Homo sapiens 114-118 31434871-4 2019 Herein, we investigated the cellular response of p53-inactivated and telomerase-expressing (immortalized) FTSECs (Pax8+/FoxJ1-) to NTBI (presented as ferric ammonium citrate (FAC), supplemented in media for >2 months) in order to assess its ability to promote the transition to a tumor-like phenotype; this cellular response was compared with immortalized FTSECs transformed with H-RasV12A and c-MycT58A. ntbi 131-135 forkhead box J1 Homo sapiens 120-125 31231185-2 2019 The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI). ntbi 259-263 solute carrier family 11 member 2 Homo sapiens 168-196 31231185-2 2019 The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI). ntbi 259-263 solute carrier family 11 member 2 Homo sapiens 198-202 31231185-2 2019 The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by Divalent Metal Transporter 1 (DMT1), responsible for Non-Transferrin Bound Iron transport (NTBI). ntbi 259-263 transferrin Homo sapiens 225-236 31309086-1 2019 An increase in biochemical concentrations of non-transferrin bound iron (NTBI) within the patients with an increase in serum iron concentration was evaluated with the following objectives: (a) Iron overloading diseases/conditions with free radicle form of "iron containing" reactive oxygen species (ROS) and its imbalance mediated mortality, and (b) Intervention with iron containing drugs in context to increased redox iron concentration and treatment induced mortality. ntbi 73-77 transferrin Homo sapiens 49-60 31143309-15 2019 Conclusions: Elevated Hgb and Hct levels in HH may be secondary to increased iron uptake by erythroid cell precursors in the bone marrow, in setting of increased availability of both transferrin-bound as well as non-transferrin-bound iron (NTBI). ntbi 240-244 transferrin Homo sapiens 183-194 30201907-2 2018 Plasma non-transferrin-bound iron (NTBI) is potentially harmful due to the generation of free radicals that cause tissue damage in vascular and other diseases. ntbi 35-39 transferrin Homo sapiens 11-22 30316781-6 2019 A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6. ntbi 44-48 transferrin Homo sapiens 75-86 30316781-6 2019 A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6. ntbi 44-48 solute carrier family 39 member 14 Homo sapiens 119-124 30316781-6 2019 A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6. ntbi 44-48 doublesex and mab-3 related transcription factor 1 Homo sapiens 162-166 30316781-6 2019 A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6. ntbi 44-48 solute carrier family 39 member 8 Homo sapiens 168-172 30316781-6 2019 A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6. ntbi 44-48 transient receptor potential cation channel subfamily C member 6 Homo sapiens 178-183 30510932-2 2018 Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron (NTBI). ntbi 200-204 transferrin Homo sapiens 176-187 30996139-7 2019 Consequently, classical monocytes displayed superior scavenging capabilities of potentially toxic NTBI, which were augmented by blocking iron export via hepcidin. ntbi 98-102 hepcidin antimicrobial peptide Homo sapiens 153-161 30806852-2 2019 In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury. ntbi 114-118 transferrin Homo sapiens 90-101 30806852-10 2019 Our data suggest that human proximal tubular epithelial cells take up TBI and NTBI, where ZIP8 and ZIP14 are both involved in NTBI uptake, but ZIP14, not ZIP8, mediates TBI-derived iron uptake. ntbi 78-82 solute carrier family 39 member 8 Homo sapiens 90-94 30806852-10 2019 Our data suggest that human proximal tubular epithelial cells take up TBI and NTBI, where ZIP8 and ZIP14 are both involved in NTBI uptake, but ZIP14, not ZIP8, mediates TBI-derived iron uptake. ntbi 78-82 solute carrier family 39 member 14 Homo sapiens 99-104 30806852-10 2019 Our data suggest that human proximal tubular epithelial cells take up TBI and NTBI, where ZIP8 and ZIP14 are both involved in NTBI uptake, but ZIP14, not ZIP8, mediates TBI-derived iron uptake. ntbi 126-130 solute carrier family 39 member 8 Homo sapiens 90-94 30806852-10 2019 Our data suggest that human proximal tubular epithelial cells take up TBI and NTBI, where ZIP8 and ZIP14 are both involved in NTBI uptake, but ZIP14, not ZIP8, mediates TBI-derived iron uptake. ntbi 126-130 solute carrier family 39 member 14 Homo sapiens 99-104 28261264-2 2017 BPAN is a movement disorder with Non Transferrin Bound Iron (NTBI) accumulation in the basal ganglia as common hallmark between NBIA classes (Hayflick et al., 2013). ntbi 61-65 transferrin Homo sapiens 37-48 29966105-3 2018 Excess iron in the form of non-transferrin-bound iron (NTBI) causes injury and is readily uptaken by cardiomyocytes, pancreatic islet cells, and hepatocytes. ntbi 55-59 transferrin Homo sapiens 31-42 29610275-4 2018 We found that these cells preferentially take up NTBI in response to the proinflammatory stimulus lipopolysaccharide (LPS) or beta-amyloid (Abeta). ntbi 49-53 amyloid beta (A4) precursor protein Mus musculus 126-146 29266790-10 2018 CONCLUSION: Alcohol-induced cardiac injury is associated with excessive NTBI uptake mediated by Ang II-LTCC activation which may be mediated by quercetin against ethanol cardiotoxicity. ntbi 72-76 angiotensinogen Rattus norvegicus 96-102 28694024-10 2017 The influx of NTBI seems to be mediated by ZIP14 transporter in the liver and by calcium channels in the cardiomyocytes. ntbi 14-18 solute carrier family 39 member 14 Homo sapiens 43-48 29735522-6 2018 We further found that the presence of non-transferrin-bound iron (NTBI) in the circulation is more important than total plasma or tissue iron in rendering mice susceptible to infection and mortality. ntbi 66-70 transferrin Mus musculus 42-53 29735522-7 2018 Postinfection treatment of HKO mice with just two doses of the hepcidin agonist PR73 abolished NTBI and completely prevented sepsis-associated mortality. ntbi 95-99 hepcidin antimicrobial peptide Mus musculus 63-71 29808889-1 2018 Blood contains a poorly characterized pool of labile iron called non-transferrin-bound iron (NTBI). ntbi 93-97 transferrin Homo sapiens 69-80 29490098-11 2018 Studies with 65Zn, 59Fe [nontransferrin-bound iron (NTBI)] and 54Mn show that ZIP14 transports these metals. ntbi 52-56 solute carrier family 39 (zinc transporter), member 14 Mus musculus 78-83 29490098-12 2018 At a steady state, the plasma concentrations of zinc, NTBI, and manganese are such that zinc ions are the major substrate available for ZIP14 at the cell surface. ntbi 54-58 solute carrier family 39 (zinc transporter), member 14 Mus musculus 136-141 28465342-3 2017 Using mouse models, we show that hepcidin was selectively protective against siderophilic extracellular pathogens (Yersinia enterocolitica O9) by controlling non-transferrin-bound iron (NTBI) rather than iron-transferrin concentration. ntbi 186-190 hepcidin antimicrobial peptide Mus musculus 33-41 27917462-5 2017 NTBI correlated with soluble transferrin receptor (sTfR), labile plasma iron (LPI) and nucleated red blood cells (NRBCs), with elevations generally confined to previously transfused patients. ntbi 0-4 transferrin receptor Homo sapiens 29-49 27903581-6 2017 We found that overexpression of ZIP14 and ZIP8, but not DMT1, resulted in increased NTBI uptake by betalox5 cells, a human beta-cell line. ntbi 84-88 solute carrier family 39 member 14 Homo sapiens 32-37 27903581-6 2017 We found that overexpression of ZIP14 and ZIP8, but not DMT1, resulted in increased NTBI uptake by betalox5 cells, a human beta-cell line. ntbi 84-88 solute carrier family 39 member 8 Homo sapiens 42-46 27903581-7 2017 Conversely, siRNA-mediated knockdown of ZIP14, but not ZIP8, resulted in 50% lower NTBI uptake in betalox5 cells. ntbi 83-87 solute carrier family 39 member 14 Homo sapiens 40-45 27903581-8 2017 In primary human islets, knockdown of ZIP14 also reduced NTBI uptake by 50%. ntbi 57-61 solute carrier family 39 member 14 Homo sapiens 38-43 27903581-11 2017 Collectively, these observations identify ZIP14 as a major contributor to NTBI uptake by beta-cells and suggest differential regulation of ZIP14 in primary human islets compared with other cell types such as hepatocytes. ntbi 74-78 solute carrier family 39 member 14 Homo sapiens 42-47 28573162-3 2016 The measurement of tissue transferrin- and non-transferrin-bound iron (TBI and NTBI, respectively) uptake in vivo can be achieved via intravenous administration of 59Fe-labeled TBI or NTBI followed by gamma counting of various organs. ntbi 79-83 transferrin Mus musculus 26-37 28157471-4 2017 RESULTS: Circulating levels of Ang-1, Ang-2 and Tie-2 were significantly higher in PTB than in individuals with LTBI or NTBI. ntbi 120-124 TEK receptor tyrosine kinase Homo sapiens 48-53 27696454-1 2017 BACKGROUND: Transfusion of a single unit of stored red blood cells (RBCs) has been hypothesized to induce supra-physiological levels of non-transferrin bound iron (NTBI), which may enhance inflammation and act as a nutrient for bacteria. ntbi 164-168 transferrin Homo sapiens 140-151 27344508-1 2016 Nontransferrin-bound iron (NTBI) is a heterogeneously speciated plasma iron, typically detectable when transferrin saturation (TfSat) exceeds 75%. ntbi 27-31 transferrin Homo sapiens 3-14 28573162-3 2016 The measurement of tissue transferrin- and non-transferrin-bound iron (TBI and NTBI, respectively) uptake in vivo can be achieved via intravenous administration of 59Fe-labeled TBI or NTBI followed by gamma counting of various organs. ntbi 79-83 transferrin Mus musculus 47-58 28573162-3 2016 The measurement of tissue transferrin- and non-transferrin-bound iron (TBI and NTBI, respectively) uptake in vivo can be achieved via intravenous administration of 59Fe-labeled TBI or NTBI followed by gamma counting of various organs. ntbi 184-188 transferrin Mus musculus 26-37 25435028-0 2015 Non transferrin bound iron (NTBI) in acute leukemias throughout conventional intensive chemotherapy: kinetics of its appearance and potential predictive role in infectious complications. ntbi 28-32 transferrin Homo sapiens 4-15 25964094-3 2015 Non-transferrin-bound iron (NTBI) is a form of free-plasma iron that is a good indicator of iron overload. ntbi 28-32 transferrin Homo sapiens 4-15 26241638-2 2015 Non-Transferrin Bound Iron (NTBI) induces cardiac toxicity through the production of reactive oxygen species and lipid peroxidation. ntbi 28-32 transferrin Homo sapiens 4-15 26028554-2 2015 These tissues preferentially load iron because they take up non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload. ntbi 88-92 transferrin Mus musculus 64-75 26028554-4 2015 We report that ablation of Slc39a14, the gene coding for solute carrier SLC39A14 (also called ZIP14), in mice markedly reduced the uptake of plasma NTBI by the liver and pancreas. ntbi 148-152 solute carrier family 39 (zinc transporter), member 14 Mus musculus 27-35 26028554-4 2015 We report that ablation of Slc39a14, the gene coding for solute carrier SLC39A14 (also called ZIP14), in mice markedly reduced the uptake of plasma NTBI by the liver and pancreas. ntbi 148-152 solute carrier family 39 (zinc transporter), member 14 Mus musculus 72-80 26028554-4 2015 We report that ablation of Slc39a14, the gene coding for solute carrier SLC39A14 (also called ZIP14), in mice markedly reduced the uptake of plasma NTBI by the liver and pancreas. ntbi 148-152 solute carrier family 39 (zinc transporter), member 14 Mus musculus 94-99 25862412-1 2015 Excess circulating iron is stored in the liver, and requires reduction of non-Tf-bound iron (NTBI) and transferrin (Tf) iron at the plasma membrane and endosomes, respectively, by ferrireductase (FR) proteins for transport across biological membranes through divalent metal transporters. ntbi 93-97 transferrin Mus musculus 78-80 25862412-4 2015 Likewise, preferential radiolabeling of circulating NTBI with (59)Fe revealed significantly reduced uptake and storage of NTBI by the liver of PrP(-/-) mice relative to matched PrP(+/+) controls. ntbi 52-56 prion protein Mus musculus 143-146 25862412-4 2015 Likewise, preferential radiolabeling of circulating NTBI with (59)Fe revealed significantly reduced uptake and storage of NTBI by the liver of PrP(-/-) mice relative to matched PrP(+/+) controls. ntbi 122-126 prion protein Mus musculus 143-146 26089776-3 2015 Different calcium permeable channels as well as the divalent metal transporter 1 (DMT1) have been proposed to sustain NTBI entry in neurons and astrocytes even though it remains an open issue. ntbi 118-122 solute carrier family 11 member 2 Homo sapiens 52-80 26089776-3 2015 Different calcium permeable channels as well as the divalent metal transporter 1 (DMT1) have been proposed to sustain NTBI entry in neurons and astrocytes even though it remains an open issue. ntbi 118-122 solute carrier family 11 member 2 Homo sapiens 82-86 25572394-5 2015 Here, we report that PrP(C) promotes the uptake of transferrin (Tf) and non-Tf-bound iron (NTBI) by the kidney in vivo and mainly NTBI by PT cells in vitro. ntbi 91-95 prion protein Mus musculus 21-24 25572394-5 2015 Here, we report that PrP(C) promotes the uptake of transferrin (Tf) and non-Tf-bound iron (NTBI) by the kidney in vivo and mainly NTBI by PT cells in vitro. ntbi 130-134 prion protein Mus musculus 21-24 25572394-10 2015 Furthermore, excess NTBI and hemin caused aggregation of PrP(C) to a detergent-insoluble form, limiting iron uptake. ntbi 20-24 prion protein Mus musculus 57-60 25765800-9 2015 In this review, the iron regulatory peptide-hormone hepcidin and non-transferrin-bound iron (NTBI) are introduced as novel potential biomarkers for iron metabolism. ntbi 93-97 transferrin Homo sapiens 69-80 26029793-3 2015 Although non-transferrin-bound iron (NTBI) is a reliable indicator for iron overload, it is still not universally available. ntbi 37-41 transferrin Homo sapiens 13-24 27428732-5 2016 Our results demonstrated that HFe rats had increased plasma non-transferrin bound iron (NTBI), malondialdehyde (MDA), cardiac iron and MDA levels and cardiac mitochondrial dysfunction, leading to LV dysfunction. ntbi 88-92 homeostatic iron regulator Rattus norvegicus 30-33 25862412-8 2015 Together, these observations indicate that PrP(C) promotes, and possibly regulates, the uptake of NTBI through DMT1 and Zip14 via its FR activity. ntbi 98-102 prion protein Mus musculus 43-49 25862412-8 2015 Together, these observations indicate that PrP(C) promotes, and possibly regulates, the uptake of NTBI through DMT1 and Zip14 via its FR activity. ntbi 98-102 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus 111-115 25862412-8 2015 Together, these observations indicate that PrP(C) promotes, and possibly regulates, the uptake of NTBI through DMT1 and Zip14 via its FR activity. ntbi 98-102 solute carrier family 39 (zinc transporter), member 14 Mus musculus 120-125 25649872-13 2015 Zip8 and Steap2 are strongly expressed in the plasma membrane of both soma and processes, implying a crucial role in iron accumulation from NTBI and transferrin-bound iron (TBI) by hippocampal neurons. ntbi 140-144 solute carrier family 39 member 8 Rattus norvegicus 0-4 25649872-13 2015 Zip8 and Steap2 are strongly expressed in the plasma membrane of both soma and processes, implying a crucial role in iron accumulation from NTBI and transferrin-bound iron (TBI) by hippocampal neurons. ntbi 140-144 STEAP2 metalloreductase Rattus norvegicus 9-15 25624847-3 2014 Overt labile plasma iron (LPI) represents a component of non-transferrin bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload. ntbi 85-89 transferrin Homo sapiens 61-72 25624847-10 2014 In hemodialyzed patients NTBI correlated with hsCRP (r = 0.37, p < 0.01), ferritin (r = 0.41, p < 0.001), IL-6 (r = 0.43, p < 0.001). ntbi 25-29 interleukin 6 Homo sapiens 112-116 25209728-2 2014 Relative mechanisms of plasma non-transferrin bound iron (NTBI) generation may account for these differences. ntbi 58-62 transferrin Homo sapiens 34-45 24960650-1 2014 BACKGROUND: Recent studies have shown large increases in non-transferrin-bound iron (NTBI) and biomarkers of oxidative stress in the extracellular medium of packed red blood cell units during storage. ntbi 85-89 transferrin Homo sapiens 61-72 25093426-1 2014 The reliable measurement of non-transferrin-bound iron (NTBI) in serum has proved to be difficult and generally time consuming. ntbi 56-60 transferrin Homo sapiens 32-43 25072389-7 2014 In this assay, NTBI is chelated by nitrilotriacetic acid (NTA), after which the iron is reduced and transferred to nitroso-PSAP, a chromogen. ntbi 15-19 prosaposin Homo sapiens 123-127 24721683-3 2014 NGAL is also an iron trafficking protein, a member of the non-transferrin-bound iron (NTBI) pool and an alternative to the transferrin-mediated iron-delivery pathway. ntbi 86-90 lipocalin 2 Homo sapiens 0-4 23361852-3 2013 Since iron elicits its effect in a transferrin (Tf)-free environment, in this work we postulate that non-transferrin-bound iron (NTBI) uptake must be involved. ntbi 129-133 transferrin Rattus norvegicus 105-116 24278199-3 2013 In iron overload disorders, however, iron concentrations exceed transferrin binding capacity and iron appears complexed with low molecular weight molecules, known as non-transferrin-bound iron (NTBI). ntbi 194-198 transferrin Homo sapiens 170-181 24616700-1 2014 In iron overload disorders a significant fraction of the total iron circulates in the plasma as low molecular weight complexes not bound to transferrin, known as non-transferrin-bound iron (NTBI). ntbi 190-194 transferrin Homo sapiens 166-177 24616700-8 2014 NTBI retention by T lymphocytes is shown to be critically controlled by the hepcidin-mediated modulation of ferroportin both in vitro and in vivo. ntbi 0-4 hepcidin antimicrobial peptide Homo sapiens 76-84 23475935-2 2013 Non-transferrin bound iron (NTBI) may contribute to TRIM by promoting oxidative damage and pro-inflammatory cytokine release. ntbi 28-32 transferrin Homo sapiens 4-15 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 0-4 interleukin 1 beta Homo sapiens 246-254 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 0-4 interleukin 6 Homo sapiens 256-260 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 0-4 C-X-C motif chemokine ligand 8 Homo sapiens 262-265 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 0-4 tumor necrosis factor Homo sapiens 269-277 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 115-119 interleukin 1 beta Homo sapiens 246-254 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 115-119 interleukin 6 Homo sapiens 256-260 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 115-119 C-X-C motif chemokine ligand 8 Homo sapiens 262-265 23475935-9 2013 NTBI levels were higher after transfusion (p<0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha. ntbi 115-119 tumor necrosis factor Homo sapiens 269-277 23508576-2 2013 DMT1 is also present in the liver, where it has been implicated in the uptake of transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI), which appears in the plasma during iron overload. ntbi 142-146 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus 0-4 22434419-3 2012 We show that hBMVEC actively reduce non-transferrin bound Fe(III) (NTBI) and transferrin-bound Fe(III) (TBI); this activity is associated with one or more ferrireductases. ntbi 67-71 transferrin Homo sapiens 40-51 23151373-7 2013 plasma non-transferrin-bound iron (NTBI) declined from 3.10+-0.25muM to 2.15+-0.29muM (p=0.028). ntbi 35-39 transferrin Homo sapiens 11-22 22281055-3 2012 Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons. ntbi 265-269 hypoxia inducible factor 1 subunit alpha Homo sapiens 106-116 22198321-5 2012 We herein demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (ferroportin1) proteins, and thus increase tansferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release in astrocytes. ntbi 274-278 hypoxia inducible factor 1 subunit alpha Homo sapiens 107-117 22459167-1 2012 In chronic kidney diseases, NTBI can occur even when total iron levels in serum are low and transferrin is not saturated. ntbi 28-32 transferrin Homo sapiens 92-103 22281055-3 2012 Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons. ntbi 265-269 transferrin Homo sapiens 202-213 21653899-1 2011 Recent studies have shown that overexpression of the transmembrane protein Zrt- and Irt-like protein 14 (Zip14) stimulates the cellular uptake of zinc and nontransferrin-bound iron (NTBI). ntbi 182-186 solute carrier family 39 (zinc transporter), member 14 Mus musculus 105-110 22089858-2 2012 Considerably less is known about the effect of increased plasma levels of redox-reactive non-transferrin bound iron (NTBI) and its impact on pulmonary endothelium. ntbi 117-121 transferrin Rattus norvegicus 93-104 22125177-1 2012 Non-transferrin bound iron (NTBI) is commonly detected in patients with systemic iron overload whose serum iron-binding capacity has been surpassed. ntbi 28-32 transferrin Homo sapiens 4-15 22398912-2 2012 A potential aggravating role of non-transferrin-bound iron (NTBI) has been proposed. ntbi 60-64 transferrin Homo sapiens 36-47 21720715-1 2011 Non-transferrin-bound iron (NTBI) refers to all forms of iron in the plasma that bind to ligands other than transferrin, and is considered to be a marker of iron toxicity. ntbi 28-32 transferrin Homo sapiens 4-15 21996204-3 2011 Overt labile plasma iron (LPI) represents a component of non-transferrin-bound iron (NTBI) that is both redox active and chelatable, capable of permeating into organs and inducing tissue iron overload. ntbi 85-89 transferrin Homo sapiens 61-72 21757620-3 2011 AMH correlated with non-transferrin-bound iron (NTBI), suggesting a role of labile iron in the pathogenesis of decreased reproductive capacity, possibly occurring in parallel to cardiac iron toxicity, as cardiac iron was associated with the presence of amenorrhea and with NTBI levels. ntbi 48-52 anti-Mullerian hormone Homo sapiens 0-3 21757620-3 2011 AMH correlated with non-transferrin-bound iron (NTBI), suggesting a role of labile iron in the pathogenesis of decreased reproductive capacity, possibly occurring in parallel to cardiac iron toxicity, as cardiac iron was associated with the presence of amenorrhea and with NTBI levels. ntbi 273-277 anti-Mullerian hormone Homo sapiens 0-3 21720715-1 2011 Non-transferrin-bound iron (NTBI) refers to all forms of iron in the plasma that bind to ligands other than transferrin, and is considered to be a marker of iron toxicity. ntbi 28-32 transferrin Homo sapiens 108-119 21462111-3 2010 The most likely explanation is the appearance of non-transferrin-bound iron (NTBI) in the plasma. ntbi 77-81 transferrin Homo sapiens 53-64 21177636-5 2011 NTBI was present in fetal serum, CF and AF, presumably as a consequence of low transferrin concentrations in these compartments. ntbi 0-4 transferrin Homo sapiens 79-90 21177636-9 2011 The low transferrin concentrations and the presence of NTBI in CF and AF suggest that transferrin-independent iron transfer is important in early gestation. ntbi 55-59 transferrin Homo sapiens 86-97 21084824-4 2010 This fact indicates that the release of non-transferrin bound iron (NTBI) occurs and then, NTBI binds with transferrin immediately thereafter. ntbi 68-72 transferrin Homo sapiens 44-55 21084824-4 2010 This fact indicates that the release of non-transferrin bound iron (NTBI) occurs and then, NTBI binds with transferrin immediately thereafter. ntbi 91-95 transferrin Homo sapiens 107-118 20704529-1 2010 BACKGROUND: Non-transferrin-bound iron (NTBI) is a powerful promoter of free radical damage and highly toxic to biological systems, resulting in oxidative damage to proteins, lipids and DNA. ntbi 40-44 transferrin Homo sapiens 16-27 21653899-10 2011 Whereas zinc appears to be a preferred substrate under normal conditions, we found that Zip14 is capable of mediating cellular uptake of NTBI characteristic of iron-overload conditions. ntbi 137-141 solute carrier family 39 (zinc transporter), member 14 Mus musculus 88-93 21438013-5 2011 Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1. ntbi 209-213 hepcidin antimicrobial peptide Homo sapiens 60-68 21438013-5 2011 Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1. ntbi 209-213 hepcidin antimicrobial peptide Homo sapiens 94-102 21438013-5 2011 Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1. ntbi 209-213 hepcidin antimicrobial peptide Homo sapiens 94-102 22123642-2 2011 The likely explanation is that the rate of iron influx into the plasma from high-dose oral supplements exceeds the rate of iron binding to transferrin and a quantity of non-transferrin-bound iron (NTBI) is formed. ntbi 197-201 transferrin Homo sapiens 173-184 21462111-4 2010 NTBI forms when the rate of iron influx into the plasma exceeds the rate of iron binding to transferrin. ntbi 0-4 transferrin Homo sapiens 92-103 20607173-1 2010 Accurate estimation of non-transferrin bound iron (NTBI) is an important tool in monitoring effects of chemotherapy and iron chelation therapy in various conditions of iron overload and transfusion related thalassemias. ntbi 51-55 transferrin Homo sapiens 27-38 19152427-3 2009 NTBI can be taken up by hepatocytes through a transferrin-independent pathway. ntbi 0-4 transferrin Mus musculus 46-57 20712765-3 2010 The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of non-transferrin-bound iron (NTBI). ntbi 144-148 transferrin Homo sapiens 76-87 20712765-3 2010 The outpouring of catabolic iron that exceeds the iron-carrying capacity of transferrin results in the emergence of non-transferrin-bound iron (NTBI). ntbi 144-148 transferrin Homo sapiens 120-131 20549524-1 2010 Iron and zinc are essential for normal brain function, yet the mechanisms used by astrocytes to scavenge non-transferrin-bound iron (NTBI) and zinc are not well understood. ntbi 133-137 transferrin Rattus norvegicus 109-120 20549524-4 2010 It was found that astrocytes express mRNA for both divalent metal transporter 1 (DMT1) and Zip14, indicating the potential for these transporters to contribute to the accumulation of NTBI and zinc by these cells. ntbi 183-187 RoBo-1 Rattus norvegicus 51-79 20549524-4 2010 It was found that astrocytes express mRNA for both divalent metal transporter 1 (DMT1) and Zip14, indicating the potential for these transporters to contribute to the accumulation of NTBI and zinc by these cells. ntbi 183-187 RoBo-1 Rattus norvegicus 81-85 19632191-1 2009 Transfusional iron overload associated with thalassemia leads to the appearance of non-transferrin-bound iron (NTBI) in blood that is toxic and causes morbidity and mortality via tissue damage. ntbi 111-115 transferrin Homo sapiens 87-98 18992790-4 2009 The resulting non-transferrin bound iron (NTBI) can catalyze the production of highly reactive oxygen species (ROS) leading to significant and wide spread injury to the liver, heart, and endocrine organs as well as increases in infection. ntbi 42-46 transferrin Homo sapiens 18-29 20627190-0 2010 Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone. ntbi 67-71 transferrin Homo sapiens 43-54 20627190-1 2010 In iron overload conditions, plasma contains non-transferrin bound iron species, collectively referred to as plasma NTBI. ntbi 116-120 transferrin Homo sapiens 49-60 19505594-2 2009 Human serum albumin (HSA) is known as a low affinity iron binding protein and it has been proposed as a ligand for the non-transferrin-bound iron (NTBI) pool existing in the sera of iron-overload patients, but definitive evidence is still lacking. ntbi 147-151 albumin Homo sapiens 6-19