PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 20096328-3 2010 Among these derivatives, 15-HAEA has been shown to be an effective (K(i) approximately 0.6 muM) FAAH inhibitor, that blocks also type-1 cannabinoid receptor (CB1R) but not other components of the "endocannabinoid system (ECS)", like the AEA transporter (AMT) or CB2R. 15-hydroxyanandamide 25-32 latexin Homo sapiens 91-94 20096328-3 2010 Among these derivatives, 15-HAEA has been shown to be an effective (K(i) approximately 0.6 muM) FAAH inhibitor, that blocks also type-1 cannabinoid receptor (CB1R) but not other components of the "endocannabinoid system (ECS)", like the AEA transporter (AMT) or CB2R. 15-hydroxyanandamide 25-32 fatty acid amide hydrolase Homo sapiens 96-100 20096328-3 2010 Among these derivatives, 15-HAEA has been shown to be an effective (K(i) approximately 0.6 muM) FAAH inhibitor, that blocks also type-1 cannabinoid receptor (CB1R) but not other components of the "endocannabinoid system (ECS)", like the AEA transporter (AMT) or CB2R. 15-hydroxyanandamide 25-32 cannabinoid receptor 1 Homo sapiens 158-162 20096328-4 2010 Here, we extended the study of the effect of 15-HAEA on the AEA synthetase (NAPE-PLD) and the AEA-binding vanilloid receptor (TRPV1), showing that 15-HAEA activates the former (up to approximately 140% of controls) and inhibits the latter protein (down to approximately 70%). 15-hydroxyanandamide 45-52 N-acyl phosphatidylethanolamine phospholipase D Homo sapiens 76-84 20096328-4 2010 Here, we extended the study of the effect of 15-HAEA on the AEA synthetase (NAPE-PLD) and the AEA-binding vanilloid receptor (TRPV1), showing that 15-HAEA activates the former (up to approximately 140% of controls) and inhibits the latter protein (down to approximately 70%). 15-hydroxyanandamide 45-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 20096328-4 2010 Here, we extended the study of the effect of 15-HAEA on the AEA synthetase (NAPE-PLD) and the AEA-binding vanilloid receptor (TRPV1), showing that 15-HAEA activates the former (up to approximately 140% of controls) and inhibits the latter protein (down to approximately 70%). 15-hydroxyanandamide 147-154 N-acyl phosphatidylethanolamine phospholipase D Homo sapiens 76-84 20096328-4 2010 Here, we extended the study of the effect of 15-HAEA on the AEA synthetase (NAPE-PLD) and the AEA-binding vanilloid receptor (TRPV1), showing that 15-HAEA activates the former (up to approximately 140% of controls) and inhibits the latter protein (down to approximately 70%). 15-hydroxyanandamide 147-154 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 20096328-6 2010 In addition, we synthesized methyl and acetyl derivatives of 15-HAEA (15-MeOAEA and 15-AcOAEA, respectively), in order to check their ability to modulate FAAH and the other ECS elements. 15-hydroxyanandamide 61-68 fatty acid amide hydrolase Homo sapiens 154-158 20096328-10 2010 Further molecular dynamics analysis gave clues to the molecular requirements for the interaction of 15-HAEA and 15-MeOAEA with FAAH. 15-hydroxyanandamide 100-107 fatty acid amide hydrolase Homo sapiens 127-131