PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18637345-1	2008	Flocculation of kaolin suspensions using ternary polymerization flocculant (CAS) synthesized by chitosan (CTS), acrylamide and ethyl acrylate quaternary ammonium salt was investigated in lab-scale.	Acrylamide	112-122	BCAR1 scaffold protein, Cas family member	Homo sapiens	76-79
18457989-4	2008	RESULTS: We demonstrated that the relative position of the VP7 gene of three G2 strains varied depending upon the concentration of acrylamide in a PAGE gel, which occurred not only in a homologous G2 virus gene background but also in a heterologous G3 virus gene background; and the VP7 gene bearing G1, G3, G4 or G9 specificity did not display this phenomenon when the PAGE running conditions were varied.	Acrylamide	131-141	chromosome 6 open reading frame 47	Homo sapiens	283-316
21791377-2	2008	The effects of bacterial lipopolysaccharide, chloroquine diphosphate and acrylamide were studied on GFAP expression and LPS, chloroquine diphosphate, ethanol, trimethyltin chloride (TMTC) and acrylamide were examined on interleukin-6 (IL-6) release in the U373-MG line only.	Acrylamide	73-83	glial fibrillary acidic protein	Homo sapiens	100-104
18418580-0	2008	Human CYP2E1 mediates the formation of glycidamide from acrylamide.	Acrylamide	56-66	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	6-12
27873843-0	2008	A Voltammetric Biosensor Based on Glassy Carbon Electrodes Modified with Single-Walled Carbon Nanotubes/Hemoglobin for Detection of Acrylamide in Water Extracts from Potato Crisps.	Acrylamide	132-142	hemoglobin	Solanum tuberosum	104-114
27873843-3	2008	Acrylamide forms adduct with hemoglobin (Hb) as a result of the reaction the -NH2 group of the Nterminal valine with acrylamide.	Acrylamide	0-10	hemoglobin	Solanum tuberosum	29-39
27873843-3	2008	Acrylamide forms adduct with hemoglobin (Hb) as a result of the reaction the -NH2 group of the Nterminal valine with acrylamide.	Acrylamide	117-127	hemoglobin	Solanum tuberosum	29-39
18624432-1	2008	Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA).	Acrylamide	0-10	hemoglobin subunit gamma 1	Homo sapiens	275-279
18624432-4	2008	A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively.	Acrylamide	23-33	hemoglobin subunit gamma 1	Homo sapiens	124-128
18624434-0	2008	Inhibition of rat testicular nuclear kinesins (krp2; KIFC5A) by acrylamide as a basis for establishing a genotoxicity threshold.	Acrylamide	64-74	kinesin family member 2C	Rattus norvegicus	47-51
18624434-3	2008	Two kinesin motors, KIFC5A and KRP2, which are responsible for spindle assembly and disassembly of kinetochore MT, respectively, are inhibited by acrylamide.	Acrylamide	146-156	kinesin family member 2C	Rattus norvegicus	31-35
18624451-3	2008	Further biochemical studies showed that acrylamide could significantly inactivate creatine kinase and glutathione S-transferase and deplete glutathione.	Acrylamide	40-50	glutathione S-transferase kappa 1	Homo sapiens	102-127
18407966-0	2008	Acrylamide-induced molecular mutation spectra at HPRT locus in human promyelocytic leukaemia HL-60 and NB4 cell lines.	Acrylamide	0-10	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	49-53
18023302-1	2007	By DNA microarray and protein 2-DE screens for Caenorhabditis elegans genes up-regulated by acrylamide, we selected the gst-4 gene and constructed a gst::gfp fusion gene, which was used to transform C. elegans into a biosensor for acrylamide.	Acrylamide	92-102	Glutathione S-transferase 4	Caenorhabditis elegans	120-125
18543763-1	2008	The effect of inhibitors, 1-deazaadenosine (1-dAdo) and erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA), on the conformation of adenosine deaminase was studied using the method of selective quenching of fluorescence emission by acrylamide, I- and Cs+.	Acrylamide	224-234	adenosine deaminase	Homo sapiens	124-143
17660004-0	2008	Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion.	Acrylamide	37-47	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	97-103
18303190-1	2008	When human neuroblastoma cells (SH-SY5Y) were exposed to 0.5 - 5 mM acrylamide for 18 hr, the levels of heat shock proteins (HSPs) of 90, 70 and 27 kDa (Hsp90, Hsp70, and Hsp27, respectively) were elevated in the incubation media depending on the dose of acrylamide whereas only the Hsp70 level increased within cells.	Acrylamide	68-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	153-158
17989133-7	2008	Although all encoded GST and were more than twofold upregulated by acrylamide treatment, their expression patterns were varied, and their regulation involved the transcription factor SKN-1 (a C. elegans homolog of Nuclear factor E2-related factors 1 and 2).	Acrylamide	67-77	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	183-188
17989133-8	2008	We then selected the gst-4::gfp-transformed C. elegans to study the detoxification rate of acrylamide and its metabolite glycidimide in living animals.	Acrylamide	91-101	Glutathione S-transferase 4	Caenorhabditis elegans	21-26
18048324-2	2007	alpha-1-Acid glycoprotein (AGP) was isolated from the sera of severely septic patients by HPLC and acrylamide gel electrophoresis and identified by mass spectrometry.	Acrylamide	99-109	orosomucoid 1	Rattus norvegicus	27-30
17979661-2	2007	In particular, cytochrome P450 2E1 (CYP2E1) is implicated in the oxidative bioactivation of a variety of small hydrophobic chemicals including a number of epoxide-forming drugs and environmentally important toxicants including urethane, acrylamide, acrylonitrile, benzene, vinyl chloride, styrene, 1-bromopropane, trichloroethylene, dichloroethylene, acetaminophen, and butadiene.	Acrylamide	237-247	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	15-34
17913331-5	2007	The trajectory shows myosin transduction of free energy to mechanical work giving evidence for: (i) a causal relationship between product release and work production in the native isoform that is correctly disrupted in a chemically modified protein, (ii) the molecular basis of ATP-sensitive tryptophan fluorescence enhancement and acrylamide quenching, (iii) an actin-binding site peptide containing the free-energy barrier to ATPase product release defining the rate limiting step and, (iv) a scenario for actin-activation of myosin ATPase.	Acrylamide	332-342	myosin heavy chain 14	Homo sapiens	21-27
17913331-5	2007	The trajectory shows myosin transduction of free energy to mechanical work giving evidence for: (i) a causal relationship between product release and work production in the native isoform that is correctly disrupted in a chemically modified protein, (ii) the molecular basis of ATP-sensitive tryptophan fluorescence enhancement and acrylamide quenching, (iii) an actin-binding site peptide containing the free-energy barrier to ATPase product release defining the rate limiting step and, (iv) a scenario for actin-activation of myosin ATPase.	Acrylamide	332-342	myosin heavy chain 14	Homo sapiens	528-534
18049993-3	2007	Acrylamide is neurotoxic and is metabolized by cytochrome P-450 (CYP) 2E1 to a mutagenic epoxide, glycidamide.	Acrylamide	0-10	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	47-73
18049993-9	2007	Early life immaturities tended to exert a greater effect on acrylamide than glycidamide dosimetry because immaturities in CYP2E1 and glutathione counteract one another for glycidamide AUC, but both lead to greater acrylamide dose.	Acrylamide	60-70	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	122-128
17979661-6	2007	Data presented in this review demonstrated that the most comprehensive studies using Cyp2e1-/- mice, encompassing the entire paradigm of metabolism to toxicity, genotoxicity, and carcinogenicity were possible when a substrate was primarily metabolized via CYP2E1 (e.g. urethane and acrylamide).	Acrylamide	282-292	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	85-91
17979661-6	2007	Data presented in this review demonstrated that the most comprehensive studies using Cyp2e1-/- mice, encompassing the entire paradigm of metabolism to toxicity, genotoxicity, and carcinogenicity were possible when a substrate was primarily metabolized via CYP2E1 (e.g. urethane and acrylamide).	Acrylamide	282-292	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	256-262
17979661-2	2007	In particular, cytochrome P450 2E1 (CYP2E1) is implicated in the oxidative bioactivation of a variety of small hydrophobic chemicals including a number of epoxide-forming drugs and environmentally important toxicants including urethane, acrylamide, acrylonitrile, benzene, vinyl chloride, styrene, 1-bromopropane, trichloroethylene, dichloroethylene, acetaminophen, and butadiene.	Acrylamide	237-247	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	36-42
17676886-10	2007	Calmodulin binding to fesselin altered the environment of the tryptophan residues so that they became less sensitive to the quencher acrylamide.	Acrylamide	133-143	calmodulin 2	Gallus gallus	0-10
17685646-1	2007	The interaction of hydrophobically modified copolymers of acrylamide and acrylic acid, designated as PAM-C12-AA (X%) (X% indicates the percentage of acrylic acid unit and X = 5, 10, 20), with dimyristoylphosphatidylcholine (DMPC) vesicles has been studied.	Acrylamide	58-68	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	101-104
17434939-6	2007	The extent of quenching of lysozyme tryptophan fluorescence by acrylamide decreased upon membrane binding, revealing a conformational transition for the protein upon its surface association, resulting in a diminished access of the fluorophore to the aqueous phase.	Acrylamide	63-73	lysozyme C, tracheal isozyme	Bos taurus	27-35
17350247-7	2007	FTIR study confirmed the complexation between Cu(II)-MIIP and Cu(II) metal ion through carbonyl oxygen of acryl amide.	Acrylamide	106-117	migration and invasion inhibitory protein	Homo sapiens	53-57
17506977-4	2007	Stopped-flow light-scattering measurements indicated high UT-B permeability to urea and chemical analogues formamide, acetamide, methylurea, methylformamide, ammonium carbamate, and acrylamide, each with P(s)>5.0 x 10(-6) cm/s at 10 degrees C. UT-B genetic knockout and phloretin treatment of wildtype erythrocytes similarly reduced urea analogue permeabilities.	Acrylamide	182-192	solute carrier family 14 (urea transporter), member 1	Mus musculus	58-62
17506977-5	2007	Strong temperature dependencies of formamide, acetamide, acrylamide and butyramide transport across UT-B-null membranes (E(a)>10 kcal/mol) suggested efficient diffusion of these amides across lipid bilayers.	Acrylamide	57-67	solute carrier family 14 (urea transporter), member 1	Mus musculus	100-104
16932918-2	2007	The caspase-3 activity and cell population in sub-G(1) phase were elevated and peaked on exposure to 3 mM acrylamide, while both were less so at higher dose (4 and 5 mM).	Acrylamide	106-116	caspase 3	Homo sapiens	4-13
17456423-6	2007	Performance tests of TNT imprinted polymer beads showed that acrylamide (AA) and more pronounced also methacrylic acid (MAA) possessed an enhanced adsorption tendency for gaseous TNT.	Acrylamide	61-71	chromosome 16 open reading frame 82	Homo sapiens	21-24
17456423-6	2007	Performance tests of TNT imprinted polymer beads showed that acrylamide (AA) and more pronounced also methacrylic acid (MAA) possessed an enhanced adsorption tendency for gaseous TNT.	Acrylamide	61-71	chromosome 16 open reading frame 82	Homo sapiens	179-182
17033922-5	2007	The two analogs, which have an acrylamide or a methyl vinyl ketone replacing the acrylic acid group of GW7604, display lower binding affinity for ER alpha than GW7604, but show similar antagonism of estradiol-induced activation of ER alpha-mediated transcription as GW7604 and inhibit estradiol-induced proliferation of the MCF-7 cell line with a similar potency as GW7604.	Acrylamide	31-41	estrogen receptor 1	Homo sapiens	146-154
16932918-5	2007	Thus, although mechanisms other than caspase-dependent apoptosis may be involved, apoptotic process seems to take place in the genesis of toxicity of acrylamide in SH-SY5Y cells through ERK pathway and activation of caspase-3.	Acrylamide	150-160	mitogen-activated protein kinase 1	Homo sapiens	186-189
16932918-5	2007	Thus, although mechanisms other than caspase-dependent apoptosis may be involved, apoptotic process seems to take place in the genesis of toxicity of acrylamide in SH-SY5Y cells through ERK pathway and activation of caspase-3.	Acrylamide	150-160	caspase 3	Homo sapiens	216-225
17010649-1	2006	Acrylamide, a known disrupter of intermediate filaments, has been used to produce the collapse of vimentin filaments in bovine lens epithelial (BEL) cells, and its potential modulation of staurosporine-induced apoptosis has been investigated.	Acrylamide	0-10	vimentin	Bos taurus	98-106
17267090-2	2007	As the intestinal mechanisms of acrylamide absorption are poorly investigated we studied the transport of acrylamide in differentiated Caco-2 cells and its effects on biotransformation enzymes (CYP2E1 and glutathione S-transferase) and glutathione levels.	Acrylamide	106-116	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	194-200
17267090-2	2007	As the intestinal mechanisms of acrylamide absorption are poorly investigated we studied the transport of acrylamide in differentiated Caco-2 cells and its effects on biotransformation enzymes (CYP2E1 and glutathione S-transferase) and glutathione levels.	Acrylamide	106-116	glutathione S-transferase kappa 1	Homo sapiens	205-230
17010649-2	2006	In BEL cells, short treatments with acrylamide caused the collapse of vimentin filaments and microtubules and the almost complete disappearance of stress fibers, with thick f-actin bundles remaining in the cell periphery.	Acrylamide	36-46	vimentin	Bos taurus	70-78
17010649-2	2006	In BEL cells, short treatments with acrylamide caused the collapse of vimentin filaments and microtubules and the almost complete disappearance of stress fibers, with thick f-actin bundles remaining in the cell periphery.	Acrylamide	36-46	actin epsilon 1	Bos taurus	175-180
17010649-3	2006	Actin organization was less affected in cells pretreated with colchicine and in spreading cells, suggesting that extended microtubules and vimentin filaments are required for acrylamide to produce its maximal effects.	Acrylamide	175-185	actin epsilon 1	Bos taurus	0-5
17010649-3	2006	Actin organization was less affected in cells pretreated with colchicine and in spreading cells, suggesting that extended microtubules and vimentin filaments are required for acrylamide to produce its maximal effects.	Acrylamide	175-185	vimentin	Bos taurus	139-147
16876394-7	2006	Vimentin intermediate filaments were disrupted in high-density monolayer articular chondrocyte cultures using acrylamide for 7 days.	Acrylamide	110-120	vimentin	Homo sapiens	0-8
16803457-4	2006	Quenching of intrinsic Pgp tryptophan fluorescence by acrylamide, iodide and caesium indicated that conformational changes took place upon formation of the trapped complexes.	Acrylamide	54-64	ATP binding cassette subfamily B member 1	Homo sapiens	23-26
16803457-5	2006	Trapping with V(i) and ATP led to a 6-fold increase in the acrylamide quenching constant, K(SV), suggesting that large conformational changes take place in the Pgp transmembrane regions on trapping in the forward direction.	Acrylamide	59-69	ATP binding cassette subfamily B member 1	Homo sapiens	160-163
16942069-1	2006	CdS/PAM nanocomposites have been successfully synthesized in situ via a ultrasound-assisted route under ambient condition, employing CdCl(2) and Na(2)S(2)O(3) as Cd(2+) and S(2-) ion sources and acrylamide (AM) and (NH(4))(2)S(2)O(8) as organic monomers and initiating reagents, respectively.	Acrylamide	195-205	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
16942069-1	2006	CdS/PAM nanocomposites have been successfully synthesized in situ via a ultrasound-assisted route under ambient condition, employing CdCl(2) and Na(2)S(2)O(3) as Cd(2+) and S(2-) ion sources and acrylamide (AM) and (NH(4))(2)S(2)O(8) as organic monomers and initiating reagents, respectively.	Acrylamide	195-205	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	4-7
16866500-10	2006	In addition, coupling of the Pfp ester of Cbz-protected phenylalanine with an acrylamide leads only to reduction of the acrylamide and recovered ester, whereas the same coupling with the N-acyl oxazolidinone derivative provides the gamma-keto amides.	Acrylamide	78-88	perforin 1	Homo sapiens	29-32
16866500-10	2006	In addition, coupling of the Pfp ester of Cbz-protected phenylalanine with an acrylamide leads only to reduction of the acrylamide and recovered ester, whereas the same coupling with the N-acyl oxazolidinone derivative provides the gamma-keto amides.	Acrylamide	120-130	perforin 1	Homo sapiens	29-32
16421929-5	2006	Fluorescence quenching experiments by acrylamide show that while Trp6 in the native protein is less solvent-exposed, its accessibility is increased significantly at low urea concentration indicating that the early intermediate state is partially unfolded.	Acrylamide	38-48	transient receptor potential cation channel subfamily C member 6	Homo sapiens	65-69
16343728-8	2006	The concentration of thiobarbituric acid reactive substances, and the activities of glutathione S-transferase and superoxide dismutase in plasma, liver, testes, brain, and kidney were increased in acrylamide-treated rats.	Acrylamide	197-207	hematopoietic prostaglandin D synthase	Rattus norvegicus	84-109
16180010-0	2006	Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide.	Acrylamide	183-193	mitogen-activated protein kinase 1	Homo sapiens	19-64
16180010-0	2006	Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide.	Acrylamide	183-193	tumor protein p53	Homo sapiens	95-98
16180010-1	2006	Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined.	Acrylamide	52-62	tumor protein p53	Homo sapiens	66-69
16180010-2	2006	Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2).	Acrylamide	0-10	transformation related protein 53, pseudogene	Mus musculus	21-24
16180010-2	2006	Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2).	Acrylamide	0-10	transformation related protein 53, pseudogene	Mus musculus	41-44
16180010-2	2006	Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2).	Acrylamide	0-10	tumor protein p53	Homo sapiens	41-44
16180010-2	2006	Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2).	Acrylamide	0-10	transformed mouse 3T3 cell double minute 2	Mus musculus	97-101
16180010-4	2006	Among mitogen-activated protein kinases (MAPKs), acrylamide caused phosphorylation of extracellular signal-regulated protein kinase (ERK) and p38 but not c-Jun NH(2)-terminal kinase.	Acrylamide	49-59	mitogen-activated protein kinase 1	Homo sapiens	86-131
16180010-4	2006	Among mitogen-activated protein kinases (MAPKs), acrylamide caused phosphorylation of extracellular signal-regulated protein kinase (ERK) and p38 but not c-Jun NH(2)-terminal kinase.	Acrylamide	49-59	mitogen-activated protein kinase 1	Homo sapiens	133-136
16180010-4	2006	Among mitogen-activated protein kinases (MAPKs), acrylamide caused phosphorylation of extracellular signal-regulated protein kinase (ERK) and p38 but not c-Jun NH(2)-terminal kinase.	Acrylamide	49-59	mitogen-activated protein kinase 14	Homo sapiens	142-145
16180010-9	2006	Hence, acrylamide increases p53 protein and its phosphorylation at Ser15 through ERK and/or PIKK pathways.	Acrylamide	7-17	tumor protein p53	Homo sapiens	28-31
16180010-9	2006	Hence, acrylamide increases p53 protein and its phosphorylation at Ser15 through ERK and/or PIKK pathways.	Acrylamide	7-17	mitogen-activated protein kinase 1	Homo sapiens	81-84
16180010-11	2006	Thus, ERK pathway seems to play a role both in causing the phosphorylation of p53 at Ser15 and in the cytotoxicity of acrylamide in SH-SY5Y cells.	Acrylamide	118-128	mitogen-activated protein kinase 1	Homo sapiens	6-9
16480393-1	2006	A functional immunoadsorption wall for removal of beta-2-microglobulin has been made by partially incomplete two-stage copolymerization of acrylamide with immunoadsorbent.	Acrylamide	139-149	beta-2-microglobulin	Homo sapiens	50-70
16190863-9	2006	The tryptophan residues in CYP2D6 appeared to be less accessible for the external quenchers iodide and acrylamide in presence of MAMC, indicating a tightening of the enzyme structure upon substrate binding.	Acrylamide	103-113	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	27-33
16242231-0	2006	Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system.	Acrylamide	33-43	BCL2, apoptosis regulator	Rattus norvegicus	73-78
16372102-1	2006	3-Hydroxy-2-methylpropionamide, an important intermediate in the synthesis of methyl methacrylate, has been obtained with excellent conversion and high selectivity from acrylamide by a tandem hydroformylation-hydrogenation sequence catalysed by Rh/PPh3 and Raney Ni, respectively.	Acrylamide	169-179	caveolin 1	Homo sapiens	248-252
16242231-0	2006	Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system.	Acrylamide	33-43	BCL2 associated X, apoptosis regulator	Rattus norvegicus	80-83
16242231-0	2006	Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system.	Acrylamide	33-43	caspase 3	Rattus norvegicus	88-97
16328246-2	2006	In this study, bovine serum albumin-imprinted soft-wet polyacrylamide gel beads were prepared via inverse-phase suspension polymerization, using acrylamide and N,N"-methylene diacrylamide as polymeric matrix components and methacrylic acid as functional monomer.	Acrylamide	59-69	albumin	Homo sapiens	22-35
16129430-7	2005	Also, several HSPs (Hsp90, Hsc70, Hsp70, Hsp60, Hsp47, Hsp40, and Hsp27) were detected outside of the cells after the treatment with acrylamide, indicating that these HSPs are released from necrotically dead cells.	Acrylamide	133-143	heat shock protein 90 alpha family class A member 1	Homo sapiens	20-25
16141435-0	2005	Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts.	Acrylamide	37-47	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	8-14
16300400-7	2005	The position of the maximum intrinsic tryptophan fluorescence and titration with hydrophilic collisional quenchers KI, acrylamide, and trichloroethanol suggested that most of Trps in hSGLT1 in solution are in a hydrophobic environment.	Acrylamide	119-129	solute carrier family 5 member 1	Homo sapiens	183-189
16129430-7	2005	Also, several HSPs (Hsp90, Hsc70, Hsp70, Hsp60, Hsp47, Hsp40, and Hsp27) were detected outside of the cells after the treatment with acrylamide, indicating that these HSPs are released from necrotically dead cells.	Acrylamide	133-143	heat shock protein family A (Hsp70) member 8	Homo sapiens	27-32
16129430-7	2005	Also, several HSPs (Hsp90, Hsc70, Hsp70, Hsp60, Hsp47, Hsp40, and Hsp27) were detected outside of the cells after the treatment with acrylamide, indicating that these HSPs are released from necrotically dead cells.	Acrylamide	133-143	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
16129430-7	2005	Also, several HSPs (Hsp90, Hsc70, Hsp70, Hsp60, Hsp47, Hsp40, and Hsp27) were detected outside of the cells after the treatment with acrylamide, indicating that these HSPs are released from necrotically dead cells.	Acrylamide	133-143	heat shock protein family D (Hsp60) member 1	Homo sapiens	41-46
16129430-7	2005	Also, several HSPs (Hsp90, Hsc70, Hsp70, Hsp60, Hsp47, Hsp40, and Hsp27) were detected outside of the cells after the treatment with acrylamide, indicating that these HSPs are released from necrotically dead cells.	Acrylamide	133-143	serpin family H member 1	Homo sapiens	48-53
16129430-7	2005	Also, several HSPs (Hsp90, Hsc70, Hsp70, Hsp60, Hsp47, Hsp40, and Hsp27) were detected outside of the cells after the treatment with acrylamide, indicating that these HSPs are released from necrotically dead cells.	Acrylamide	133-143	DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1	Homo sapiens	55-60
16129430-7	2005	Also, several HSPs (Hsp90, Hsc70, Hsp70, Hsp60, Hsp47, Hsp40, and Hsp27) were detected outside of the cells after the treatment with acrylamide, indicating that these HSPs are released from necrotically dead cells.	Acrylamide	133-143	heat shock protein family B (small) member 1	Homo sapiens	66-71
16101137-4	2005	The expression of MnSOD and, less strongly, Cu/ZnSOD activity, as assessed by acrylamide gel electrophoresis, was inhibited by EUG, suggesting mitochondrial dysfunction.	Acrylamide	78-88	superoxide dismutase 2	Homo sapiens	18-23
15982677-1	2005	Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activity of acrylamide.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	164-170
15982677-1	2005	Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activity of acrylamide.	Acrylamide	283-293	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	164-170
15982677-9	2005	In those experiments, dose-related increases in dominant lethal mutations were detected in uterine contents of female mice mated to acrylamide-treated wild-type males but not CYP2E1-null males, clearly implicating CYP2E1-mediated formation of glycidamide in the induction of genetic damage in male germ cells.	Acrylamide	132-142	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	214-220
15982677-15	2005	These results support the hypothesis that genetic damage in somatic and germ cells of mice-treated with acrylamide is dependent upon metabolism of the parent compound by CYP2E1.	Acrylamide	104-114	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	170-176
15982677-17	2005	CYP2E1 polymorphisms and variability in CYP2E1 activity associated with, for example, diabetes, obesity, starvation, and alcohol consumption, may result in altered metabolic efficiencies leading to differential susceptibilities to acrylamide toxicities in humans.	Acrylamide	231-241	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
15982677-17	2005	CYP2E1 polymorphisms and variability in CYP2E1 activity associated with, for example, diabetes, obesity, starvation, and alcohol consumption, may result in altered metabolic efficiencies leading to differential susceptibilities to acrylamide toxicities in humans.	Acrylamide	231-241	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	40-46
16161713-9	2005	The limited stratum-specific numbers showed that the exposed workers with the GSTM1-/GSTT1-genotype had nonsignificantly higher frequencies of all the effect parameters than the unexposed workers; this finding indicates that individual susceptibility related to the detoxification of acrylamide and N-methylolacrylamide may have played a role in the observed effect.	Acrylamide	284-294	glutathione S-transferase mu 1	Homo sapiens	78-83
16179550-2	2005	In this study, 24-h acrylamide treatment significantly increased the initial rate of l-[G-3H]glutamine uptake in astrocyte cultures derived from the acrylamide-sensitive Fischer 344 rat, and this effect could be fully inhibited by histidine, a model substrate for the amino acid transport system N. RT-PCR analysis revealed that acrylamide treatment caused a significant increase in the astrocytic expression of the mRNA coding for the major system N protein, SNAT3, which is specifically overexpressed in malignant gliomas in situ.	Acrylamide	20-30	solute carrier family 38, member 3	Rattus norvegicus	460-465
16161713-9	2005	The limited stratum-specific numbers showed that the exposed workers with the GSTM1-/GSTT1-genotype had nonsignificantly higher frequencies of all the effect parameters than the unexposed workers; this finding indicates that individual susceptibility related to the detoxification of acrylamide and N-methylolacrylamide may have played a role in the observed effect.	Acrylamide	284-294	glutathione S-transferase theta 1	Homo sapiens	85-90
15668107-4	2005	Enzymes that enhance conjugation with glutathione (GSH), the glutathione transferases (GSTs), may influence the detoxification of both acrylamide and glycidamide, whereas the enzyme epoxide hydrolase (EH) should only catalyse the hydrolysis of glycidamide.	Acrylamide	135-145	glutathione S-transferase mu 1	Homo sapiens	87-91
15848178-6	2005	Tryptophan intrinsic fluorescence increase, fluorescence quenching by both acrylamid and hypocrellin B decrease, and MIANS fluorescence decrease, indicate that the conformation of PMCA embedded in lipid l(o) phase is more compact than in lipid l(d) phase.	Acrylamide	75-84	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	180-184
15720385-4	2005	We applied the iodide and acrylamide fluorescence quenching method in order to study how different DNA sequences and cAMP binding induce the conformational changes in the CRP molecule.	Acrylamide	26-36	catabolite gene activator protein	Escherichia coli	171-174
15668113-1	2005	Micronucleus (MN) induction in erythrocytes of multiple intestinal neoplasia (Min) mice with heterozygous Apc mutation was measured after s.c. injections of acrylamide, glycidamide, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and colchicine, and compared with wild-type (wt) mice.	Acrylamide	157-167	APC, WNT signaling pathway regulator	Mus musculus	47-76
15628884-4	2005	Reduced SP-Br exhibited higher structural flexibility than native SP-B, as indicated by a higher susceptibility of fluorescence emission to quenching by acrylamide and biphasic behavior during interaction of the protein with lipid bilayers and monolayers.	Acrylamide	153-163	surfactant protein B	Homo sapiens	8-12
16438288-16	2005	Treatment with a sulfhydryl donor compound (NAC) reduced acrylamide transformation while depletion of GSH (BSO) resulted in an enhancement of transformation.	Acrylamide	57-67	synuclein alpha	Homo sapiens	44-47
16438295-5	2005	The dose of acrylamide or glycidamide has been measured in blood samples from individuals with defined genotypes for the glutathione transferases GSTT1 and GSTM1 after in vitro incubation with these compounds.	Acrylamide	12-22	glutathione S-transferase theta 1	Homo sapiens	146-151
16438295-5	2005	The dose of acrylamide or glycidamide has been measured in blood samples from individuals with defined genotypes for the glutathione transferases GSTT1 and GSTM1 after in vitro incubation with these compounds.	Acrylamide	12-22	glutathione S-transferase mu 1	Homo sapiens	156-161
16438297-5	2005	An alternative proposal is that the corresponding decarboxylated Amadori compound may release acrylamide by a beta-elimination reaction.	Acrylamide	94-104	amyloid beta precursor protein	Homo sapiens	108-114
15556356-2	2004	Glucose oxidase (GOx) and the water-dispersed polypyrrole complex were entrapped within polyacrylamide microgels by polymerization of acrylamide in the dispersed phase of concentrated emulsions containing GOx and PPy.	Acrylamide	92-102	hydroxyacid oxidase 1	Homo sapiens	0-15
15355880-0	2005	Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect.	Acrylamide	89-99	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	45-51
15355880-5	2005	A key oxidative metabolite of acrylamide is the epoxide glycidamide, generated by cytochrome P4502E1 (CYP2E1).	Acrylamide	30-40	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	82-100
15355880-5	2005	A key oxidative metabolite of acrylamide is the epoxide glycidamide, generated by cytochrome P4502E1 (CYP2E1).	Acrylamide	30-40	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	102-108
15355880-10	2005	No changes in any fertility parameters were seen in females mated to acrylamide-treated CYP2E1-null mice.	Acrylamide	69-79	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	88-94
15355880-11	2005	Our results constitute the first unequivocal demonstration that acrylamide-induced germ cell mutations in male mice require CYP2E1-mediated epoxidation of acrylamide.	Acrylamide	64-74	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	124-130
15355880-11	2005	Our results constitute the first unequivocal demonstration that acrylamide-induced germ cell mutations in male mice require CYP2E1-mediated epoxidation of acrylamide.	Acrylamide	155-165	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	124-130
15355880-12	2005	Thus, CYP2E1 polymorphisms in human populations, resulting in variable enzyme metabolic activities, may produce differential susceptibilities to acrylamide toxicities.	Acrylamide	145-155	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	6-12
15556356-2	2004	Glucose oxidase (GOx) and the water-dispersed polypyrrole complex were entrapped within polyacrylamide microgels by polymerization of acrylamide in the dispersed phase of concentrated emulsions containing GOx and PPy.	Acrylamide	92-102	hydroxyacid oxidase 1	Homo sapiens	17-20
15003292-0	2004	Upregulation of the pro-opiomelanocortin gene in motoneurones after acrylamide administration in mice.	Acrylamide	68-78	pro-opiomelanocortin-alpha	Mus musculus	20-40
15501435-4	2004	We also investigated effect of acrylamide on caspase-3 activity as well as its influence on the repair process of hydrogen peroxide-induced DNA damage.	Acrylamide	31-41	caspase 3	Homo sapiens	45-54
15501435-9	2004	Acrylamide impaired the repair of DNA damaged by hydrogen peroxide and increased the activity of caspase-3, which may indicate its potential to induce apoptosis.	Acrylamide	0-10	caspase 3	Homo sapiens	97-106
15240786-6	2004	RESULTS: Acrylamide and glycidamide formed DNA adducts at similar specific locations within TP53 and cII, and DNA adduct formation was more pronounced after glycidamide treatment than after acrylamide treatment at all doses tested.	Acrylamide	9-19	tumor protein p53	Homo sapiens	92-96
15240786-6	2004	RESULTS: Acrylamide and glycidamide formed DNA adducts at similar specific locations within TP53 and cII, and DNA adduct formation was more pronounced after glycidamide treatment than after acrylamide treatment at all doses tested.	Acrylamide	9-19	lambda CII family protein	Escherichia virus Lambda	101-104
15081597-6	2004	In a separate study, subcutaneous injections of FK506 (2 or 10 mg/kg) for 2 weeks markedly increased heat shock protein-70 (Hsp-70) immunostaining in sensory neurons, motor neurons, Purkinje cells, and other regions of the brain (in particular, the amygdala) from nonintoxicated and AC-intoxicated rats compared to controls.	Acrylamide	283-285	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	124-130
15081597-7	2004	In contrast, AC-intoxicated animals not given FK506 demonstrated reduced Hsp-70 staining.	Acrylamide	13-15	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	73-79
14985092-3	2004	The fluorescence quenching efficiencies of iodide and acrylamide are substantially reduced, indicating a shielding of phenylalanine residue of bradykinin from aqueous environment.	Acrylamide	54-64	kininogen 1	Homo sapiens	143-153
15003292-3	2004	It seems likely that upregulation of the POMC gene precedes acrylamide-induced neuropathy.	Acrylamide	60-70	pro-opiomelanocortin-alpha	Mus musculus	41-45
15043924-8	2004	The accessibility of the single tryptophan in Rev monomer to acrylamide quenching increases with decreasing protein concentration.	Acrylamide	61-71	Rev	Human immunodeficiency virus 1	46-49
13678149-9	2003	The source of PAM derivatives is the unpolymerized acrylamide formed during electrophoresis.	Acrylamide	51-61	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	14-17
14617531-7	2004	Disruption of intermediate filaments with acrylamide did prevent the fluid shear stress-induced increase in cyclooxygenase-2 but also prevented a PGE(2)-induced increase in cyclooxygenase-2.	Acrylamide	42-52	prostaglandin-endoperoxide synthase 2	Mus musculus	108-124
14617531-7	2004	Disruption of intermediate filaments with acrylamide did prevent the fluid shear stress-induced increase in cyclooxygenase-2 but also prevented a PGE(2)-induced increase in cyclooxygenase-2.	Acrylamide	42-52	prostaglandin-endoperoxide synthase 2	Mus musculus	173-189
14757316-0	2004	Reactions of acrylamide with glutathione and serum albumin.	Acrylamide	13-23	albumin	Homo sapiens	45-58
14757316-1	2004	Rate constants of 0.0054 and 0.021 M(-1)s(-1) for the reactions of acrylamide with human serum albumin (HSA) and glutathione (GSH), respectively, were determined under physiological conditions by following the loss of their thiol groups in the presence of excess acrylamide.	Acrylamide	67-77	albumin	Homo sapiens	89-102
14757316-1	2004	Rate constants of 0.0054 and 0.021 M(-1)s(-1) for the reactions of acrylamide with human serum albumin (HSA) and glutathione (GSH), respectively, were determined under physiological conditions by following the loss of their thiol groups in the presence of excess acrylamide.	Acrylamide	263-273	albumin	Homo sapiens	89-102
14597854-7	2003	METHODS: eNOS protein expression was evaluated by separating the monomeric from the active dimeric form by low-temperature sodium dodecyl sulphate poly-acrylamide gel electrophoresis (SDS-PAGE), and mRNA was analyzed by semi-quantitative reverse transcriptase (RT)-polymerase chain reaction (PCR).	Acrylamide	152-162	nitric oxide synthase 3	Homo sapiens	9-13
14637024-8	2003	Analysis of the quenching of tryptophan residues in CYP11A1 by acrylamide indicates that at least one and probably two tryptophans are involved in membrane binding.	Acrylamide	63-73	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	52-59
14622964-6	2003	Thus, despite their small size (2-4kDa) and minor differences between their lengths, the Abeta peptides display a wide separation in this low-porosity (12% acrylamide) gel.	Acrylamide	156-166	amyloid beta precursor protein	Homo sapiens	89-94
12853321-3	2003	Statistically significant changes in acrylamide treated astrocytes were noted for GS (0.1 mM) and GLAST (1.0 mM) mRNA expression levels.	Acrylamide	37-47	solute carrier family 1 member 3	Rattus norvegicus	98-103
14690247-2	2003	Human plasma Fn HOCl/OCl(-)-mediated modification was monitored with differential OD method and with measurements of tryptophan fluorescence followed by acrylamide quenching of tryptophan emission.	Acrylamide	153-163	fibronectin 1	Homo sapiens	13-15
12661070-5	2003	A correlation was shown between the accessibility of tyrosines to acrylamide quenching and the degree of association of the insulin mutants.	Acrylamide	66-76	insulin	Homo sapiens	124-131
12705381-8	2003	The separation efficiency of cytochrome c and phycocyanin in both acrylamide and HMDS coated capillaries corresponded to a plate number of 19600 which compares favourably with capillary electrophoresis of neurotransmitters with amperometric detection.	Acrylamide	66-76	cytochrome c, somatic	Homo sapiens	29-41
12579844-5	2002	Fluorescence quenching experiments with NaI and acrylamide as quenchers showed that the KSVs (the slope of Strm-Volmer equation) of insulin were more similar to that with added liposome, indicating low interaction between insulin with liposome.	Acrylamide	48-58	insulin	Homo sapiens	132-139
12061792-7	2002	The disorganization of cellular cytoskeleton by cytochalasin D, colchicine, or acrylamide treatment disrupts CAS-stimulated HT-29 cell polarization.	Acrylamide	79-89	chromosome segregation 1 like	Homo sapiens	109-112
12113838-1	2002	To overcome the low bioavailability of our substituted acrylamide P1 benzamidine factor Xa inhibitors reported previously, neutral and less basic groups were used to replace the benzamidine.	Acrylamide	55-65	coagulation factor X	Homo sapiens	81-90
12579844-5	2002	Fluorescence quenching experiments with NaI and acrylamide as quenchers showed that the KSVs (the slope of Strm-Volmer equation) of insulin were more similar to that with added liposome, indicating low interaction between insulin with liposome.	Acrylamide	48-58	insulin	Homo sapiens	222-229
11835157-6	2002	We used the Hoffman degradation reaction to convert the amide groups of acrylamide to amine groups, and then we used ethylene glycol diglycidyl ether to attach biomolecules of interest inside the holes: secreted protein acidic and rich in cysteine (SPARC) peptide Lys-Gly-His-Lys (KGHK; angiogenic), thrombospondin-2 (TSP; antiangiogenic), or albumin (rat; neutral).	Acrylamide	72-82	secreted protein acidic and cysteine rich	Rattus norvegicus	203-247
11812921-7	2002	Cotreatment with acrylamide and N-acetyl-L-cysteine (NAC), a sulfhydryl group donor, resulted in the reduction of acrylamide-induced morphological transformation in SHE cells.	Acrylamide	17-27	X-linked Kx blood group	Homo sapiens	53-56
11812921-7	2002	Cotreatment with acrylamide and N-acetyl-L-cysteine (NAC), a sulfhydryl group donor, resulted in the reduction of acrylamide-induced morphological transformation in SHE cells.	Acrylamide	114-124	X-linked Kx blood group	Homo sapiens	53-56
11812921-9	2002	Cotreatment with acrylamide and DL-buthionone-[S,R]-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, increased the percent of morphologically transformed colonies compared to acrylamide treatment alone.	Acrylamide	17-27	glutamate-cysteine ligase catalytic subunit	Homo sapiens	96-129
11812921-10	2002	Acrylamide reduced GSH levels in SHE cells, and cotreatment with acrylamide and NAC prevented the acrylamide-induced reduction of GSH.	Acrylamide	98-108	X-linked Kx blood group	Homo sapiens	80-83
11967996-0	2002	Acrylamide disturbs the subcellular distribution of GABAA receptor in brain neurons.	Acrylamide	0-10	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	52-66
11967996-1	2002	Mechanisms underlying the action of acrylamide on neurons were studied by monitoring the expression of GABA(A) receptor (R) in cultured brain neurons derived from chicken embryos.	Acrylamide	36-46	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	103-119
11779407-0	2001	Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathies.	Acrylamide	122-132	neurotrophin 3	Rattus norvegicus	23-37
11779407-7	2001	Acrylamide-intoxicated rats treated with NT-3 had higher than control levels of muscle choline acetyltransferase activity (p < 0.05), suggesting greater muscle innervation.	Acrylamide	0-10	choline O-acetyltransferase	Rattus norvegicus	87-112
11478917-2	2001	Here we show that acrylamide induces morphological changes and tyrosine phosphorylation of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), a member of the FAK subfamily, in human differentiating neuroblastoma SH-SY5Y cells.	Acrylamide	18-28	protein tyrosine kinase 2	Homo sapiens	91-112
11479320-10	2001	Furthermore, acrylamide quenching experiments indicate that RNA binding creates heterogeneity in the solvent accessibility of ADAR2 tryptophan residues, with one out of five tryptophans more solvent-accessible in the ADAR2.RNA complex.	Acrylamide	13-23	adenosine deaminase RNA specific B1	Homo sapiens	126-131
11479320-10	2001	Furthermore, acrylamide quenching experiments indicate that RNA binding creates heterogeneity in the solvent accessibility of ADAR2 tryptophan residues, with one out of five tryptophans more solvent-accessible in the ADAR2.RNA complex.	Acrylamide	13-23	adenosine deaminase RNA specific B1	Homo sapiens	217-222
11488610-1	2001	Cofactor and tryptophan accessibility of the 65-kDa form of rat brain glutamate decarboxylase (GAD) was investigated by fluorescence quenching measurements using acrylamide, I-, and Cs+ as the quenchers.	Acrylamide	162-172	glutamate-ammonia ligase	Rattus norvegicus	70-93
11488610-1	2001	Cofactor and tryptophan accessibility of the 65-kDa form of rat brain glutamate decarboxylase (GAD) was investigated by fluorescence quenching measurements using acrylamide, I-, and Cs+ as the quenchers.	Acrylamide	162-172	glutamate-ammonia ligase	Rattus norvegicus	95-98
11478917-2	2001	Here we show that acrylamide induces morphological changes and tyrosine phosphorylation of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), a member of the FAK subfamily, in human differentiating neuroblastoma SH-SY5Y cells.	Acrylamide	18-28	protein tyrosine kinase 2	Homo sapiens	114-117
11478917-2	2001	Here we show that acrylamide induces morphological changes and tyrosine phosphorylation of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), a member of the FAK subfamily, in human differentiating neuroblastoma SH-SY5Y cells.	Acrylamide	18-28	protein tyrosine kinase 2 beta	Homo sapiens	123-153
11478917-2	2001	Here we show that acrylamide induces morphological changes and tyrosine phosphorylation of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), a member of the FAK subfamily, in human differentiating neuroblastoma SH-SY5Y cells.	Acrylamide	18-28	protein tyrosine kinase 2 beta	Homo sapiens	155-159
11478917-2	2001	Here we show that acrylamide induces morphological changes and tyrosine phosphorylation of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), a member of the FAK subfamily, in human differentiating neuroblastoma SH-SY5Y cells.	Acrylamide	18-28	protein tyrosine kinase 2	Homo sapiens	178-181
11018473-8	2000	Fluorescence quenching experiments performed with acrylamide determined phospholipase C-gamma1 incubated at pH 5.0 had a larger collisional quenching constant than enzyme incubated at pH 7.0.	Acrylamide	50-60	phospholipase C gamma 1	Homo sapiens	72-94
11042609-6	2000	The Trp-36 residue remained fully quenchable by acrylamide after desorption of hIFNgamma from the liposomes.	Acrylamide	48-58	interferon gamma	Homo sapiens	79-88
11476329-5	2001	Cellulose acetate identified more alleles at Ak and Fum, and resolved better at Pgm, whereas acrylamide identified more alleles at Gpi, Mdh, and Me.	Acrylamide	93-103	glucose-6-phosphate isomerase	Homo sapiens	131-134
11476329-5	2001	Cellulose acetate identified more alleles at Ak and Fum, and resolved better at Pgm, whereas acrylamide identified more alleles at Gpi, Mdh, and Me.	Acrylamide	93-103	malate dehydrogenase 2	Homo sapiens	136-139
11035811-4	2000	These findings, along with the discovery that the exposed heme edge of cytochrome c is involved in the cytochrome c.Apaf-1 interaction, are confirmed through enhanced chemiluminescence visualization of native PAGE gels and through acrylamide fluorescence quenching experiments.	Acrylamide	231-241	cytochrome c, somatic	Homo sapiens	71-83
11035811-4	2000	These findings, along with the discovery that the exposed heme edge of cytochrome c is involved in the cytochrome c.Apaf-1 interaction, are confirmed through enhanced chemiluminescence visualization of native PAGE gels and through acrylamide fluorescence quenching experiments.	Acrylamide	231-241	cytochrome c, somatic	Homo sapiens	103-115
11035811-4	2000	These findings, along with the discovery that the exposed heme edge of cytochrome c is involved in the cytochrome c.Apaf-1 interaction, are confirmed through enhanced chemiluminescence visualization of native PAGE gels and through acrylamide fluorescence quenching experiments.	Acrylamide	231-241	apoptotic peptidase activating factor 1	Homo sapiens	116-122
10995218-1	2000	The I28 immunoglobulin (Ig)-like module of human cardiac titin, an elastic muscle protein, was used to cross-link acrylamide (AAm) copolymers into hybrid hydrogels.	Acrylamide	114-124	titin	Homo sapiens	57-62
10995218-1	2000	The I28 immunoglobulin (Ig)-like module of human cardiac titin, an elastic muscle protein, was used to cross-link acrylamide (AAm) copolymers into hybrid hydrogels.	Acrylamide	126-129	titin	Homo sapiens	57-62
10965033-8	2000	Matrilysin contains four tryptophyls, and their states were examined by fluorescence-quenching with iodide and cesium ions and acrylamide.	Acrylamide	127-137	matrix metallopeptidase 7	Homo sapiens	0-10
10987507-1	2000	The immunohistochemical analysis of the HNK-1 epitope presence in the liver and upper digestive tract nerves was carried out in 12- to 18-day-old rat embryos embedded in acrylamide-agarose and observed with laser scanning confocal microscopy.	Acrylamide	170-180	beta-1,3-glucuronyltransferase 1	Rattus norvegicus	40-45
10898730-4	2000	Similar results were obtained from measurements on wild-type fibroblasts and endothelial cells after vimentin IFs were disrupted by acrylamide.	Acrylamide	132-142	vimentin	Homo sapiens	101-109
10615596-1	1999	A high-performance liquid chromatography method using C18 and ion-exchange columns in series is developed for the determination of acrylamide and acrylic acid monomers in polymeric samples.	Acrylamide	131-141	Bardet-Biedl syndrome 9	Homo sapiens	54-57
10885034-1	2000	Neuro-, hepato- and geno-toxic effects of the industrial xenobiotic, acrylamide, were studied in intact rats and in rats with induced phenobarbital- and 3-methylholanthren-dependent isoforms of cytochrome P-450.	Acrylamide	69-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	194-210
10720481-0	2000	Acrylamide quenching of apo- and holo-alpha-lactalbumin in guanidine hydrochloride.	Acrylamide	0-10	lactalbumin alpha	Homo sapiens	38-55
10720481-1	2000	We have examined the fluorescence properties and acrylamide quenching of calcium-loaded (holo) and calcium-depleted (apo) alpha-lactalbumin (alpha-LA) as a function of guanidine hydrochloride (GDN/HCl) concentration.	Acrylamide	49-59	lactalbumin alpha	Homo sapiens	122-139
10720481-9	2000	The results for apo-alpha-LA in dilute GDN/HCl suggest that acrylamide can penetrate the protein molecule (as judged by the collision quenching) but is unable to form a stable complex within the quenching domain for the tryptophans (as judged by the absence of the static quench constant).	Acrylamide	60-70	lactalbumin alpha	Homo sapiens	20-28
10739349-1	2000	Glutamate dehydrogenase (GDH) and lactate dehydrogenase (LDH) activity of 13 cold-adapted strains, isolated from cold soils and showing GDH and/or LDH activity in spectrophotometric assays, were revealed by the use of electrophoresis on a nondenaturing acrylamide gel (zymogram).	Acrylamide	253-263	glutamate dehydrogenase 1	Homo sapiens	0-23
10678756-1	2000	Using the rat pheochromocytoma cell line (PC12), we present molecular evidence that the neurotoxicant acrylamide directly induces neurofilament gene expression, and the signaling pathways are initially distinctive from, but eventually merged into, that for nerve growth factor (NGF)-induced neurofilament expression.	Acrylamide	102-112	nerve growth factor	Rattus norvegicus	257-276
10678756-1	2000	Using the rat pheochromocytoma cell line (PC12), we present molecular evidence that the neurotoxicant acrylamide directly induces neurofilament gene expression, and the signaling pathways are initially distinctive from, but eventually merged into, that for nerve growth factor (NGF)-induced neurofilament expression.	Acrylamide	102-112	nerve growth factor	Rattus norvegicus	278-281
10678756-6	2000	Dexamethasone reversed the effects of both NGF and acrylamide on neurofilament protein levels and synthesis indicated that there is a dexamethasone-sensitive signaling step upon which NGF and acrylamide merge, suggesting involvement of transcription-activating proteins like AP-1.	Acrylamide	51-61	nerve growth factor	Rattus norvegicus	184-187
10678756-6	2000	Dexamethasone reversed the effects of both NGF and acrylamide on neurofilament protein levels and synthesis indicated that there is a dexamethasone-sensitive signaling step upon which NGF and acrylamide merge, suggesting involvement of transcription-activating proteins like AP-1.	Acrylamide	192-202	nerve growth factor	Rattus norvegicus	43-46
9889368-8	1999	Fluorescence quenching studies indicated that incorporation of oleic acid or digestion of membrane phospholipids with PLA2 elevated the accessibility of fluorophores for acrylamide.	Acrylamide	170-180	phospholipase A2 group IB	Rattus norvegicus	118-122
10563837-0	1999	Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice.	Acrylamide	49-59	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	8-27
10547622-9	1999	Acrylamide seems to be a specific inhibitor of GAPDH and NSE, whereas the inhibition caused by HgCl(2) on the enzymes was more general.	Acrylamide	0-10	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	47-52
10547622-9	1999	Acrylamide seems to be a specific inhibitor of GAPDH and NSE, whereas the inhibition caused by HgCl(2) on the enzymes was more general.	Acrylamide	0-10	enolase 2	Rattus norvegicus	57-60
10362843-4	1999	The N22Q-V2R expressed in transfected cells migrated in denaturing acrylamide gels as two protein bands with a difference of 7000 Da.	Acrylamide	67-77	arginine vasopressin receptor 2	Homo sapiens	9-12
10362843-6	1999	Sialidase treatment of membranes from cells expressing the N22Q-V2R or of immunoprecipitated metabolically labeled V2R accelerated the migration of the protein in acrylamide gels demonstrating the existence of O-glycosylation, the first time this type of glycosylation has been found in a G protein coupled receptor.	Acrylamide	163-173	arginine vasopressin receptor 2	Homo sapiens	64-67
10362843-6	1999	Sialidase treatment of membranes from cells expressing the N22Q-V2R or of immunoprecipitated metabolically labeled V2R accelerated the migration of the protein in acrylamide gels demonstrating the existence of O-glycosylation, the first time this type of glycosylation has been found in a G protein coupled receptor.	Acrylamide	163-173	arginine vasopressin receptor 2	Homo sapiens	115-118
11593553-4	1999	The Ssp1-digested products were loaded on a gradient acrylamide gel and run for 3 hours.	Acrylamide	53-63	SUMO specific peptidase 6	Homo sapiens	4-8
9925666-5	1999	The electrophoretic mobility of the recombinant apo[a] isoforms expressed by these cells in a hollow-fiber bioreactor was determined after reduction by SDS-gel (agarose, acrylamide or a mixture of both) electrophoresis and immunoblotting using an antibody specific for human apo[a].	Acrylamide	170-180	aminopeptidase O (putative)	Homo sapiens	48-51
9800329-10	1998	A gradient of 10-15% acrylamide combined with a 15-50% ureaformamide gradient was successfully used to separate BoLA-DRB3 alleles in all individuals examined.	Acrylamide	21-31	major histocompatibility complex, class II, DRB3	Bos taurus	112-121
10919716-12	1999	Cytochalasin D and acrylamide were found to inhibit Tyr-phosphorylation of FAK and paxillin, whereas microtubule disrupting agents at low but not high concentrations increased phosphorylation of these focal adhesion proteins.	Acrylamide	19-29	protein tyrosine kinase 2	Homo sapiens	75-78
10830921-4	1999	The patients" multimeric vWF pattern was analyzed by sodium dodecylsulfate (SDS)-agarose-acrylamide electrophoresis, Western blot, and densitometric analysis.	Acrylamide	89-99	von Willebrand factor	Homo sapiens	25-28
10523783-1	1999	Delayed-extraction matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry, in both linear and reflectron modes, has been used to examine the alkylation of bovine beta-lactoglobulin-bound cysteines exposed to various molar concentrations (0.5-30 mM) of acrylamide and a number of its N-substituted monomers.	Acrylamide	286-296	beta-lactoglobulin	Bos taurus	196-214
10189590-1	1998	Activity of LDH isozymes was evaluated electrophoretically on 7% acrylamide gel in semen of 37 leprosy patients (15 with borderline, 12 with borderline tuberculoid and ten with lepromatous leprosy) and ten fertile men of 30-45 years of age.	Acrylamide	65-75	lactate dehydrogenase C	Homo sapiens	12-15
9748657-8	1998	A similar decrease in fluorescence was also observed when p47phox was phosphorylated with protein kinase C. Furthermore, a red shift of emission maximum and an increase of quenching by ionic quenchers and acrylamide were observed in the presence of activators.	Acrylamide	205-215	neutrophil cytosolic factor 1	Homo sapiens	58-65
9513813-6	1998	The extent of quenching of tryptophan fluorescence by acrylamide is less in acid and in NaClO4 solutions of IFN gamma compared to its native form.	Acrylamide	54-64	interferon gamma	Homo sapiens	108-117
9729823-2	1998	The use of formamide and a low concentration of acrylamide increased resolution and sharpness of HUMARA alleles in silver-stained polyacrylamide gels.	Acrylamide	48-58	androgen receptor	Homo sapiens	97-103
9698945-3	1998	Quenching studies demonstrated that Trp 6 and Trp 113 are "buried" to acrylamide, iodide ions and caesium ions.	Acrylamide	70-80	transient receptor potential cation channel subfamily C member 6	Homo sapiens	36-41
9601048-6	1998	However, the fluorescence of Tyr-6 in the cytoplasmic domain of PLB changed significantly upon PLB phosphorylation: phosphorylation increased the fluorescence quantum yield and decreased the quenching efficiency by acrylamide, suggesting a local structural change that decreases the solvent accessibility of Tyr-6.	Acrylamide	215-225	phospholamban	Homo sapiens	64-67
9601048-6	1998	However, the fluorescence of Tyr-6 in the cytoplasmic domain of PLB changed significantly upon PLB phosphorylation: phosphorylation increased the fluorescence quantum yield and decreased the quenching efficiency by acrylamide, suggesting a local structural change that decreases the solvent accessibility of Tyr-6.	Acrylamide	215-225	phospholamban	Homo sapiens	95-98
9691273-3	1998	Acrylamide quenching of tryptophan fluorescence in hsp90 is also principally collisional and identifies two classes of residues, one readily accessible to quenching the other less accessible.	Acrylamide	0-10	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-56
9658576-3	1998	A novel series of nonpeptide angiotensin II antagonists containing the acrylamide group at the 4-position of the imidazole ring was synthesized and their antagonistic activity was examined by functional assay in rabbit aorta.	Acrylamide	71-81	angiotensinogen	Rattus norvegicus	29-43
9446603-12	1998	Although the studies have yet to establish definitively that nkx-2.8 is the AFP gene regulator PCF, the two factors share a common DNA binding site, gel shift behavior, migration on SDS-acrylamide gels, and cellular distribution.	Acrylamide	186-196	NK2 homeobox 8	Homo sapiens	61-68
9283077-8	1997	First, the electrophoretic mobility variation induced by Fos and Jun was proportional to that caused by an intrinsic bend over a broad range of acrylamide concentrations.	Acrylamide	144-154	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-60
9711577-9	1998	This is consistent with the observation that human Pgp expressed in NIH 3T3 cells migrates faster compared to the protein from KB-V1 cells on 8-10% acrylamide gel.	Acrylamide	148-158	phosphoglycolate phosphatase	Homo sapiens	51-54
9355744-4	1997	Both methods of reconstitution led to the extensive interaction of SP-B with PC bilayers as demonstrated by co-migration during centrifugation, marked protection against proteolysis, change in the fluorescence emission intensity of SP-B, and protection of SP-B tryptophan fluorescence from quenching by acrylamide.	Acrylamide	303-313	surfactant protein B	Homo sapiens	67-71
9420175-13	1997	In conclusion, we present the first 10% and 15% acrylamide 2-D gel protein databases of neonatal rat islets of Langerhans and demonstrate its usage to identify proteins altered in expression by IL-1beta.	Acrylamide	48-58	interleukin 1 beta	Rattus norvegicus	194-202
9398290-4	1997	Comparison of the accessibility of the three lifetime classes to the fluorescence quenchers acrylamide and iodide with the computed solvent accessibility of the three Trp residues in the crystal structure of NE indicates that the main, if not the sole, contribution to the 2.28 ns lifetime class is brought about by the fully buried Trp 141 residue.	Acrylamide	92-102	elastase, neutrophil expressed	Homo sapiens	208-210
8995261-7	1997	Stern-Volmer analysis of the quenching by acrylamide and I- indicates that phi29 SSB tyrosines are surrounded by a negatively charged environment and located in a relatively exposed protein domain, accessible to the solvent and, likely, to ssDNA.	Acrylamide	42-52	single stranded DNA-binding protein	Bacillus phage phi29	81-84
22062129-6	1997	Using the sensitive test with cyanide and hydrogen peroxide, the acrylamide gel of the SOD showed this enzyme was of the Cu Zn  type.	Acrylamide	65-75	superoxide dismutase 1	Homo sapiens	87-90
9054401-5	1997	Intracellular GLUT4-containing vesicles were immunoisolated from low density microsomes by using monoclonal anti-GLUT4 (1F8) or anti-SCAMP antibodies (3F8) coupled to either agarose or acrylamide.	Acrylamide	185-195	solute carrier family 2 member 4	Rattus norvegicus	14-19
9130383-3	1997	The efficiency of quenching of membrane-bound cytochrome P450 with acrylamide also increased after freezing.	Acrylamide	67-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-61
8740660-6	1996	In the submucous plexus, the acrylamide treatment caused a decrease in calcitonin gene-related peptide immunoreactivity and an increase in vasoactive intestinal polypeptide and neuropeptide Y immunoreactivity.	Acrylamide	29-39	pyroglutamylated RFamide peptide	Rattus norvegicus	177-189
8909941-3	1996	The SSCP patterns of DRB1-DR52 group-specific products were defined in cell lines representing the DRB1*1101-06 alleles, using non-denaturing acrylamide gel electrophoresis and silver staining.	Acrylamide	142-152	major histocompatibility complex, class II, DR beta 1	Homo sapiens	21-25
8806767-5	1996	Our data demonstrate that fluorescence quenching of the proMMP-2/TIMP-2 complex by either acrylamide or iodide is significantly increased following mercurial activation.	Acrylamide	90-100	TIMP metallopeptidase inhibitor 2	Homo sapiens	65-71
8924055-8	1996	Oxygen radical-induced damage on apolipoprotein-B100 was evaluated by acrylamide and agarose gel electrophoresis.	Acrylamide	70-80	apolipoprotein B	Homo sapiens	33-52
8683730-6	1996	Cleavage of PTHrP 1-141 by PSA generated fragments on Coomassie-stained acrylamide gels that migrated with mobilities that corresponded to 19.5, 17, 15 and < 7 kd.	Acrylamide	72-82	parathyroid hormone-like peptide	Mus musculus	12-17
8683730-6	1996	Cleavage of PTHrP 1-141 by PSA generated fragments on Coomassie-stained acrylamide gels that migrated with mobilities that corresponded to 19.5, 17, 15 and < 7 kd.	Acrylamide	72-82	kallikrein B, plasma 1	Mus musculus	27-30
8856736-0	1996	Decreased GAP-43 accumulation in neurite tips of cultured hippocampal neurons by acrylamide.	Acrylamide	81-91	growth associated protein 43	Homo sapiens	10-16
9025922-3	1997	Reverse zymography is an electrophoretic technique used to identify TIMP inhibitory activity within acrylamide gels.	Acrylamide	100-110	TIMP metallopeptidase inhibitor 1	Homo sapiens	68-72
8918253-2	1996	In this work we moved to a eukaryotic system, to produce one of the most immunogenic HCMV antigens, ppUL44 (also called pp52 due to its apparent molecular size on acrylamide gels), as a non-fusion protein, in an attempt to eliminate some non-specific reactivity of human sera with bacterial carrier proteins.	Acrylamide	163-173	lymphocyte specific protein 1	Homo sapiens	120-124
8738336-4	1996	One of these monomers (N-acryloylaminopropanol, AAP) was found indeed to be extremely hydrophilic (with a partition coefficient P of only 0.10, vs. P = 0.13 for N-acryloylaminoethoxyethanol and P = 0.20 for acrylamide) and to possess excellent stability to alkaline hydrolysis.	Acrylamide	207-217	serpin family F member 2	Homo sapiens	48-51
8738336-5	1996	Its hydrolysis constant (0.008 L mol-1 min-1), as a free monomer, in an alkaline milieu, was found to be about one order of magnitude lower than conventional acrylamide (0.05 L mol-1 min-1).	Acrylamide	158-168	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
8577222-5	1995	Alterations in dehydroergosterol lifetime, SCP-2 tryptophan lifetime, and SCP-2 tryptophan quenching by acrylamide upon cholesterol binding demonstrated a shielding of the SCP-2 tryptophan from the aqueous solvent by bound sterol.	Acrylamide	104-114	sterol carrier protein 2	Homo sapiens	74-79
8845857-6	1996	Expressed CYP3A18 protein in COS-1 cells migrated at a position identical to that of purified P450(6)beta-2 on sodium dodecyl sulfate-acrylamide gel electrophoresis and catalyzed 16 beta- and 6 alpha-hydroxylations of testosterone.	Acrylamide	134-144	cytochrome P450, family 3, subfamily a, polypeptide 18	Rattus norvegicus	10-17
8845857-6	1996	Expressed CYP3A18 protein in COS-1 cells migrated at a position identical to that of purified P450(6)beta-2 on sodium dodecyl sulfate-acrylamide gel electrophoresis and catalyzed 16 beta- and 6 alpha-hydroxylations of testosterone.	Acrylamide	134-144	cytochrome P450, family 3, subfamily a, polypeptide 18	Rattus norvegicus	94-107
7499207-12	1995	Acrylamide gel electrophoresis of the protein bands corresponding to the integrin alpha L beta 2, followed by immunoblotting using monoclonal antibodies to phosphotyrosine, permitted us to demonstrate that, prior to stimulation by type I collagen, there was no phosphorylation, whereas after stimulation, both alpha L and beta 2 chains were stained by anti-phosphotyrosine antibodies.	Acrylamide	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	90-96
8746812-2	1995	When rat cerebral cortical membranes were resolved on separating gels containing 9% acrylamide and 8 M urea, three electrophoretically distinct G alpha o-immunoreactive proteins were evident.	Acrylamide	84-94	G protein subunit alpha o1	Homo sapiens	144-153
8577222-5	1995	Alterations in dehydroergosterol lifetime, SCP-2 tryptophan lifetime, and SCP-2 tryptophan quenching by acrylamide upon cholesterol binding demonstrated a shielding of the SCP-2 tryptophan from the aqueous solvent by bound sterol.	Acrylamide	104-114	sterol carrier protein 2	Homo sapiens	74-79
7779817-7	1995	Changes in the accessibility of aqueous soluble quenchers (I- and acrylamide) to GLUT-1 Trp and Tyr residues suggested that ligand binding causes interfacial fluorophores to move closer to ionic groups in the lipid head group region of the membrane.	Acrylamide	66-76	solute carrier family 2 member 1	Homo sapiens	81-87
7813487-1	1994	The cytochrome P450scc tryptophan fluorescence was studied by the use of the three quenchers acrylamide, 25-doxyl-27-nor-cholesterol (CNO) and potassium iodide (KI).	Acrylamide	93-103	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	15-22
8590598-2	1995	The iodide and acrylamide quenching data show that in CRP one tryptophan residue, Trp-85, is buried within the protein matrix and the other, Trp-13, is moderately exposed on the surface of the protein.	Acrylamide	15-25	catabolite gene activator protein	Escherichia coli	54-57
8590598-7	1995	In the CRP-cAMP complex the Trp-85, previously buried in the apoprotein becomes totally exposed to the iodide and acrylamide quenchers.	Acrylamide	114-124	catabolite gene activator protein	Escherichia coli	7-10
7639849-10	1995	Native acrylamide gel electrophoresis of plasma from six individuals, followed by 2F8/2E7 sandwich immunoblotting, showed CETP migrating within a size range of 170-220 kilodaltons.	Acrylamide	7-17	cholesteryl ester transfer protein	Homo sapiens	122-126
7864806-3	1995	N-terminal analysis of the enzyme activity protein band, electroblotted from a SDS-acrylamide gel and with an assessed molecular mass of 19 kDa, showed an identical sequence to that of alpha-chain of human C3 complement component, suggesting the presence in this band of a complex formed by a complement C3-derived anaphylatoxin (C3a)-related fragment and the PLA2 linked side-by-side.	Acrylamide	83-93	Fc gamma receptor and transporter	Homo sapiens	185-196
7723622-5	1995	In distal regions of acrylamide- and isoniazid-intoxicated nerves, NGFR-mRNA was elevated at least 2 days prior to visible signs of axonal degeneration as assayed by morphological techniques utilizing light microscopy.	Acrylamide	21-31	nerve growth factor receptor	Homo sapiens	67-71
7723622-6	1995	NGFR-mRNA was also elevated in proximal regions of axotomized and acrylamide-intoxicated nerves prior to signs of axonal degeneration.	Acrylamide	66-76	nerve growth factor receptor	Homo sapiens	0-4
7851423-7	1995	The LC17 dimer cross-linked with Nbs2 was resolved into three distinct bands on urea/PAGE using a 4% acrylamide gel.	Acrylamide	101-111	myosin light chain 6	Homo sapiens	4-8
7737089-6	1995	Acrylamide concentration for gels stained for MDH were 8.7%, gels stained for 6-PGD and PGI were 7.5%, while gels stained for SkDH had an acrylamide concentration of 5.0%.	Acrylamide	0-10	malic enzyme 1	Homo sapiens	46-49
7813487-0	1994	Interaction of tryptophan residues of cytochrome P450scc with a highly specific fluorescence quencher, a substrate analogue, compared to acrylamide and iodide.	Acrylamide	137-147	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	49-56
7607246-1	1995	The DNA-binding domain of Drosophila c-Myb protein has been studied using different spectroscopic probes, namely CD, fluorescence, acrylamide quenching and NMR, to determine the structure of some of its sub-domains and their relative stabilities in aqueous solutions.	Acrylamide	131-141	Myb oncogene-like	Drosophila melanogaster	37-42
7744774-11	1995	Tryptophan fluorescence lifetime values of 1.9 and 3.9 ns for the native and 3.5 ns for the NBS-modified epimerase, complemented by a linear Stern-Volmer plot (effective Stern-Volmer constant = 2.85 M-1) of acrylamide quenching, suggest that the two key tryptophans are buried close to an intrinsic quencher, presumably NAD.	Acrylamide	207-217	nibrin	Homo sapiens	92-95
7740544-12	1995	Acrylamide inhibited activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in sciatic and tibial nerves, as well as in brain.	Acrylamide	0-10	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	33-73
7740544-12	1995	Acrylamide inhibited activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in sciatic and tibial nerves, as well as in brain.	Acrylamide	0-10	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	75-80
7873593-4	1995	Subsequent binding of CT-B to the PC-GM1 composite vesicles causes no further change in the pyrene fluorescence emission spectrum but does appear to increase acrylamide accessibility.	Acrylamide	158-168	phosphate cytidylyltransferase 1B, choline	Homo sapiens	22-26
7813487-3	1994	Whereas a strong interaction (static quenching) between acrylamide and tryptophan in the active site had been found previously for cytochrome P450c21 [Narasimhulu, S. (1988) Biochemistry 27, 1147-1153], in the case of P450scc the temperature dependence of the slope of the linear Stern-Volmer plots indicated a dynamic quenching mechanism.	Acrylamide	56-66	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	218-225
7898611-0	1994	Attenuation of glyceraldehyde-3-phosphate dehydrogenase activity and ATP levels in rat brain synaptosomes by acrylamide.	Acrylamide	109-119	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	15-55
7833440-0	1994	Adsorption of bovine serum albumin onto acrylamide-maleic acid hydrogels.	Acrylamide	40-50	albumin	Homo sapiens	21-34
7969750-3	1994	Acrylamide given acutely (100 mg/kg, single intraperitoneal injection) causes a selective increase in NF-M mRNA (approximately 50%) compared to controls.	Acrylamide	0-10	neurofilament medium chain	Rattus norvegicus	102-106
7845318-2	1994	The apparent molecular weight (M(r)) of the oligomeric 200-kDa YadA species detected by SDS-PAGE varied from 152,000 to 240,000 depending on the respective acrylamide concentration.	Acrylamide	156-166	Adhesin	Yersinia enterocolitica	63-67
7845318-4	1994	In contrast, the apparent M(r) of 53,000 of the YadA monomer was independent of the acrylamide concentration.	Acrylamide	84-94	Adhesin	Yersinia enterocolitica	48-52
7969750-5	1994	In contrast, chronic treatment with acrylamide [0.03% (w/v) in drinking water for 4 weeks] induces a modest but significant increase (approximately 22%) in NF-L mRNA compared to controls.	Acrylamide	36-46	neurofilament light chain	Rattus norvegicus	156-160
7679116-2	1993	Here we use a technique involving elution and renaturation of proteins from SDS-acrylamide gels to identify a DNA-binding component of NF-AT (NF-ATp) that is present in hypotonic extracts of T cells prior to activation and appears in nuclear extracts when T cells are activated.	Acrylamide	80-90	nuclear factor of activated T cells 1	Bos taurus	135-140
8218257-5	1993	There was weak quenching of CHIP28 tryptophan fluorescence by the polar compounds iodide and acrylamide, with Stern-Volmer constants of 0.13 and 0.71 M-1, respectively.	Acrylamide	93-103	aquaporin 1 (Colton blood group)	Homo sapiens	28-34
8218257-6	1993	HgCl2 inhibited water permeability by > 95% at 50 microM and quenched CHIP28 fluorescence reversibly by up to 70% with a biphasic concentration dependence; quenching by HgCl2 and acrylamide was not additive.	Acrylamide	182-192	aquaporin 1 (Colton blood group)	Homo sapiens	73-79
8218257-7	1993	The membrane-associated n-AF probes quenched CHIP28 fluorescence by up to 80% with the greatest quenching for n = 2 and 12; addition of HgCl2 or acrylamide after n-AF caused a small, anthroyloxy-position-dependent increase in quenching which was greatest at n = 6.	Acrylamide	145-155	aquaporin 1 (Colton blood group)	Homo sapiens	45-51
7689863-7	1993	Quenching by acrylamide was more efficient for delta-MSH than for alpha-MSH, while the opposite was true for quenching by CCl4.	Acrylamide	13-23	proopiomelanocortin	Homo sapiens	53-56
7689863-7	1993	Quenching by acrylamide was more efficient for delta-MSH than for alpha-MSH, while the opposite was true for quenching by CCl4.	Acrylamide	13-23	proopiomelanocortin	Homo sapiens	66-75
8388334-1	1993	Circular dichroism (CD) and acrylamide quenching studies of Na+,K(+)-ATPase from human placenta showed that its incorporation into phosphatidylcholine vesicles increased the enzymic activity by 55%.	Acrylamide	28-38	dynein axonemal heavy chain 8	Homo sapiens	69-75
8499444-2	1993	The fluorescence of the single tryptophan of annexin V was used to monitor Ca2+ and/or phospholipid binding in terms of emission wavelength, emission intensity, and susceptibility to acrylamide quenching.	Acrylamide	183-193	annexin A5	Homo sapiens	45-54
8499444-4	1993	The Stern-Volmer quenching constant due to acrylamide was only 5.2 M-1 for annexin V alone, indicating limited aqueous exposure of the tryptophan, but 36 M-1 for a Ca(2+)-bound form, indicating full exposure.	Acrylamide	43-53	annexin A5	Homo sapiens	75-84
7909364-5	1994	Genomic DNA was obtained from leukocytes; amplification of the repeat region of the androgen receptor gene was performed and the products sized on an acrylamide gel.	Acrylamide	150-160	androgen receptor	Homo sapiens	84-101
8119921-5	1994	The fluorescence intensity, anisotropy, and quenching by acrylamide provide information about the DNA environment in the complexes with RecA.	Acrylamide	57-67	RAD51 recombinase	Homo sapiens	136-140
8119921-6	1994	In the absence of extra DNA, binding of RecA to BPDE-poly(dA) only slightly affects both the intensity of the BPDE fluorescence and the accessibility of BPDE to acrylamide.	Acrylamide	161-171	RAD51 recombinase	Homo sapiens	40-44
8280055-6	1993	In addition, we demonstrated a shielding of the tryptophan fluorescence from quenching by acrylamide on interaction of porcine SP-A with DPPC, DPPG or LPC.	Acrylamide	90-100	surfactant protein A1	Homo sapiens	127-131
8390468-3	1993	This protein showed an anomalous behavior in SDS-polyacrylamide gel electrophoresis as that observed in case of GAP-43 (neuromodulin, F1, pp46, p57, B-50) and MARCKS (p87, p80), namely shifts of apparent molecular weights under different acrylamide concentrations.	Acrylamide	53-63	growth associated protein 43	Rattus norvegicus	112-118
8390468-3	1993	This protein showed an anomalous behavior in SDS-polyacrylamide gel electrophoresis as that observed in case of GAP-43 (neuromodulin, F1, pp46, p57, B-50) and MARCKS (p87, p80), namely shifts of apparent molecular weights under different acrylamide concentrations.	Acrylamide	53-63	growth associated protein 43	Rattus norvegicus	120-132
8390468-3	1993	This protein showed an anomalous behavior in SDS-polyacrylamide gel electrophoresis as that observed in case of GAP-43 (neuromodulin, F1, pp46, p57, B-50) and MARCKS (p87, p80), namely shifts of apparent molecular weights under different acrylamide concentrations.	Acrylamide	53-63	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	159-165
8390468-3	1993	This protein showed an anomalous behavior in SDS-polyacrylamide gel electrophoresis as that observed in case of GAP-43 (neuromodulin, F1, pp46, p57, B-50) and MARCKS (p87, p80), namely shifts of apparent molecular weights under different acrylamide concentrations.	Acrylamide	53-63	TATA-box binding protein associated factor 6	Rattus norvegicus	172-175
8508307-1	1993	Northern blot analysis was used to study the effects of acrylamide, a potent neurotoxin, on the induction of c-fos and c-jun mRNA in rat brain.	Acrylamide	56-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-114
8508307-4	1993	Acute administration of acrylamide caused a statistically significant increase in the expression of c-fos (approx.	Acrylamide	24-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	100-105
8508307-7	1993	By contrast, the level of c-fos mRNA in chronic acrylamide treatment was not altered significantly, but the expression of c-jun mRNA was increased almost 100% as compared to control.	Acrylamide	48-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
8489704-4	1993	In contrast, acrylamide is less able to permeate this conformational state of RBP.	Acrylamide	13-23	retinol binding protein 4	Homo sapiens	78-81
8489704-5	1993	Fluorescence of tryptophan residues in riboflavin-RBP complex and chemically N-bromosucinimide-modified RBP was quenched by iodide and acrylamide.	Acrylamide	135-145	retinol binding protein 4	Homo sapiens	50-53
8489704-5	1993	Fluorescence of tryptophan residues in riboflavin-RBP complex and chemically N-bromosucinimide-modified RBP was quenched by iodide and acrylamide.	Acrylamide	135-145	retinol binding protein 4	Homo sapiens	104-107
8507302-0	1993	Effect of acrylamide on the distribution of microtubule-associated proteins (MAP1 and MAP2) in selected regions of rat brain.	Acrylamide	10-20	Blood pressure QTL 196	Rattus norvegicus	77-81
8507302-1	1993	The effect of acrylamide treatment on the immunocytochemical localization of microtubule-associated proteins (MAP1 and MAP2) was studied in different brain regions (cerebellum, cerebral cortex, and hippocampus) of adult rats.	Acrylamide	14-24	Blood pressure QTL 196	Rattus norvegicus	110-114
8507302-1	1993	The effect of acrylamide treatment on the immunocytochemical localization of microtubule-associated proteins (MAP1 and MAP2) was studied in different brain regions (cerebellum, cerebral cortex, and hippocampus) of adult rats.	Acrylamide	14-24	microtubule-associated protein 2	Rattus norvegicus	119-123
8507302-6	1993	Treatment of animals with acrylamide reduced immunoreactivity for both MAP1 and MAP2 in hippocampus and cerebellum, with relatively little change in cerebral cortex.	Acrylamide	26-36	Blood pressure QTL 196	Rattus norvegicus	71-75
8507302-6	1993	Treatment of animals with acrylamide reduced immunoreactivity for both MAP1 and MAP2 in hippocampus and cerebellum, with relatively little change in cerebral cortex.	Acrylamide	26-36	microtubule-associated protein 2	Rattus norvegicus	80-84
7679116-2	1993	Here we use a technique involving elution and renaturation of proteins from SDS-acrylamide gels to identify a DNA-binding component of NF-AT (NF-ATp) that is present in hypotonic extracts of T cells prior to activation and appears in nuclear extracts when T cells are activated.	Acrylamide	80-90	nuclear factor of activated T cells 1	Bos taurus	142-148
8442002-1	1993	Conjugation with glutathione (GSH) is a mechanism of detoxification of acrylamide (ACR); hence, prior depletion of GSH might be expected to exacerbate ACR"s neurotoxicity.	Acrylamide	71-81	acrosin	Rattus norvegicus	83-86
8442002-1	1993	Conjugation with glutathione (GSH) is a mechanism of detoxification of acrylamide (ACR); hence, prior depletion of GSH might be expected to exacerbate ACR"s neurotoxicity.	Acrylamide	71-81	acrosin	Rattus norvegicus	151-154
1495848-2	1992	Esterase pattern analysis using acrylamide-agar gel electrophoresis and determination of the antimicrobial resistance profile (agar diffusion method) were performed for A. faecalis (34 strains).	Acrylamide	32-42	alpha/beta hydrolase	Alcaligenes faecalis	0-8
8448647-0	1993	Acrylamide-induced depletion of microtubule-associated proteins (MAP1 and MAP2) in the rat extrapyramidal system.	Acrylamide	0-10	Blood pressure QTL 196	Rattus norvegicus	65-69
8448647-0	1993	Acrylamide-induced depletion of microtubule-associated proteins (MAP1 and MAP2) in the rat extrapyramidal system.	Acrylamide	0-10	microtubule-associated protein 2	Rattus norvegicus	74-78
8448647-1	1993	Acrylamide, an occupational neurotoxicant, reduced MAP1 and MAP2 distribution in different regions of rat brain.	Acrylamide	0-10	Blood pressure QTL 196	Rattus norvegicus	51-55
8448647-1	1993	Acrylamide, an occupational neurotoxicant, reduced MAP1 and MAP2 distribution in different regions of rat brain.	Acrylamide	0-10	microtubule-associated protein 2	Rattus norvegicus	60-64
8448647-2	1993	Different components of the extrapyramidal system (caudate-putamen, globus pallidus, substantia nigra and red nucleus) revealed differential distribution of MAP1 and MAP2 in acrylamide-treated animals.	Acrylamide	174-184	Blood pressure QTL 196	Rattus norvegicus	157-161
8448647-2	1993	Different components of the extrapyramidal system (caudate-putamen, globus pallidus, substantia nigra and red nucleus) revealed differential distribution of MAP1 and MAP2 in acrylamide-treated animals.	Acrylamide	174-184	microtubule-associated protein 2	Rattus norvegicus	166-170
8448647-5	1993	Acrylamide caused a near-total loss of MAP1 and MAP2 immunoreactivity in caudate-putamen.	Acrylamide	0-10	Blood pressure QTL 196	Rattus norvegicus	39-43
8448647-5	1993	Acrylamide caused a near-total loss of MAP1 and MAP2 immunoreactivity in caudate-putamen.	Acrylamide	0-10	microtubule-associated protein 2	Rattus norvegicus	48-52
8215586-8	1993	Casein-acrylamide electrophoresis showed that the molecular weight of this serine protease was about 30 kDa.	Acrylamide	7-17	coagulation factor II, thrombin	Homo sapiens	75-90
1454060-2	1992	The relative migration of Ro52, the 56K autoantigen and calreticulin increased with reduced acrylamide:bisacrylamide ratios in contrast to that of Ro60, La and Jo-1.	Acrylamide	92-102	tripartite motif containing 21	Homo sapiens	26-30
1454060-2	1992	The relative migration of Ro52, the 56K autoantigen and calreticulin increased with reduced acrylamide:bisacrylamide ratios in contrast to that of Ro60, La and Jo-1.	Acrylamide	92-102	calreticulin	Homo sapiens	56-68
1442202-4	1992	Using gel overlay assays, the binding between soluble 125I-OPN and OCN immobilized in acrylamide gels was visualized.	Acrylamide	86-96	secreted phosphoprotein 1	Rattus norvegicus	59-62
1442202-4	1992	Using gel overlay assays, the binding between soluble 125I-OPN and OCN immobilized in acrylamide gels was visualized.	Acrylamide	86-96	bone gamma-carboxyglutamate protein	Rattus norvegicus	67-70
8448647-8	1993	The depletion of MAP1 and MAP2 immunoreactivity by acrylamide appears to be an early biochemical event preceding peripheral neuropathy.	Acrylamide	51-61	Blood pressure QTL 196	Rattus norvegicus	17-21
8448647-8	1993	The depletion of MAP1 and MAP2 immunoreactivity by acrylamide appears to be an early biochemical event preceding peripheral neuropathy.	Acrylamide	51-61	microtubule-associated protein 2	Rattus norvegicus	26-30
8433098-5	1993	Another group of mice (A2), given acrylamide at a higher dose (50 mg/kg, 5 days per week, 5 weeks), showed abnormalities on the rotarod by 11 days, a progressive decrease of muscle action potential (CMAP) amplitude, and significantly decreased number of reactive SG from 15 days, with respect to controls.	Acrylamide	34-44	cystatin F (leukocystatin)	Mus musculus	199-203
1429756-1	1992	An acrylamide derivative of a thrombin inhibitor was synthesized and graft polymerized to the surfaces of polymer membranes.	Acrylamide	3-13	coagulation factor II, thrombin	Homo sapiens	30-38
1319319-6	1992	Acrylamide stimulation of steroidogenesis is additive with that produced by either colchicine or ACTH, implying that acrylamide, ACTH, and colchicine act at different rate-limiting steps in steroidogenesis.	Acrylamide	0-10	pro-opiomelanocortin-alpha	Mus musculus	129-133
1319319-6	1992	Acrylamide stimulation of steroidogenesis is additive with that produced by either colchicine or ACTH, implying that acrylamide, ACTH, and colchicine act at different rate-limiting steps in steroidogenesis.	Acrylamide	117-127	pro-opiomelanocortin-alpha	Mus musculus	97-101
1734283-3	1992	From studies on the kinetics of transcription initiation, on the composition of transcription initiation complexes fractionated by acrylamide gel electrophoresis, and on template competition experiments, TFIIF is known to act at an intermediate stage in initiation complex formation.	Acrylamide	131-141	general transcription factor IIF subunit 1	Homo sapiens	204-209
1541817-7	1992	Specific labeling of the sialoglycoproteins of RDM-4 cells indicates that leukosialin, the most intensely labeled protein, comigrates with the sulfated protein on SDS-PAGE at varying acrylamide concentrations.	Acrylamide	183-193	sialophorin	Mus musculus	74-85
1346962-0	1992	Inactivation of placental factor XIIIa by acrylamide.	Acrylamide	42-52	coagulation factor XIII A chain	Homo sapiens	26-38
1346962-1	1992	Acrylamide rapidly and irreversibly inactivates thrombin activated Factor XIIIa, without affecting neither the intact zymogen nor its proteolytic activation.	Acrylamide	0-10	coagulation factor II, thrombin	Homo sapiens	48-56
1346962-1	1992	Acrylamide rapidly and irreversibly inactivates thrombin activated Factor XIIIa, without affecting neither the intact zymogen nor its proteolytic activation.	Acrylamide	0-10	coagulation factor XIII A chain	Homo sapiens	67-79
1892827-5	1991	Quenching of DR1[NAT] and DR1[REL] using the neutral quencher acrylamide results in a 20% increase in total accessibility of the nine-residue Trp population whereas quenching by iodide yields only a 5% increase.	Acrylamide	62-72	down-regulator of transcription 1	Homo sapiens	13-16
1603853-0	1992	Acrylamide quenching of the fluorescence of glyceraldehyde-3-phosphate dehydrogenase: reversible and irreversible effects.	Acrylamide	0-10	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	44-84
1603853-1	1992	The acrylamide quenching of the tryptophan fluorescence of apo and holo glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was studied.	Acrylamide	4-14	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	72-112
1603853-1	1992	The acrylamide quenching of the tryptophan fluorescence of apo and holo glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was studied.	Acrylamide	4-14	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	114-119
1818075-1	1991	The tryptic map of horse myoglobin was analysed through capillary electrophoresis using capillaries modified by a monolayer of acrylamide.	Acrylamide	127-137	myoglobin	Equus caballus	25-34
1892827-5	1991	Quenching of DR1[NAT] and DR1[REL] using the neutral quencher acrylamide results in a 20% increase in total accessibility of the nine-residue Trp population whereas quenching by iodide yields only a 5% increase.	Acrylamide	62-72	down-regulator of transcription 1	Homo sapiens	26-29
1892836-0	1991	Inhibition of substrate binding to the adrenal cytochrome P450C-21 by acrylamide and its implications for solvent accessibility of the binding site in the microsomes.	Acrylamide	70-80	steroid 21-hydroxylase	Bos taurus	63-66
1892836-1	1991	The present study offers evidence indicating that acrylamide, a highly polar molecule and an efficient quencher of tryptophanyl fluorescence, inhibits substrate binding to P450C-21 in bovine adrenocortical microsomes, in a competitive manner similar to that in the purified enzyme.	Acrylamide	50-60	steroid 21-hydroxylase	Bos taurus	177-180
1894608-5	1991	Fatty acid binding also blocked the accessibility of L-FABP tyrosine and I-FABP tryptophan to Stern-Volmer quenching by acrylamide, indicating that these amino acids were present in the fatty acid-binding pocket.	Acrylamide	120-130	fatty acid binding protein 1	Homo sapiens	53-59
1894608-5	1991	Fatty acid binding also blocked the accessibility of L-FABP tyrosine and I-FABP tryptophan to Stern-Volmer quenching by acrylamide, indicating that these amino acids were present in the fatty acid-binding pocket.	Acrylamide	120-130	fatty acid binding protein 2	Homo sapiens	73-79
1878370-4	1991	The difference in response of the fluorescence characteristics of the bound NPM for temperature variation between the control and peroxidized membranes was also observed in the quenching efficiency with acrylamide.	Acrylamide	203-213	nucleophosmin 1	Homo sapiens	76-79
1956583-2	1991	Incubation of brain slices under oxygen in artificial cerebrospinal fluid containing acrylamide produced a dose and time dependent inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH).	Acrylamide	85-95	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	145-185
2060214-5	1991	Acrylamide electrophoresis (SDS-PAGE) and isoelectric focusing (IEF) showed that the purified BMP was homogeneous.	Acrylamide	0-10	bone morphogenetic protein 1	Homo sapiens	94-97
1954037-2	1991	The electrophoretic mobility of the major component of the new Hbb was identical to that of Hbbs on cellulose acetate plate, although it was almost identical to that of Hbbd or Hbbp on acrylamide gel.	Acrylamide	185-195	hemoglobin beta chain complex	Mus musculus	63-66
1956583-2	1991	Incubation of brain slices under oxygen in artificial cerebrospinal fluid containing acrylamide produced a dose and time dependent inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH).	Acrylamide	85-95	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	187-192
1956583-5	1991	Incubation with acrylamide depleted glutathione levels in slices, and the addition of glutathione to the incubation medium prevented acrylamide induced inhibition of GAPDH and lysosomal enzymes.	Acrylamide	133-143	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	166-171
2032208-4	1991	Acrylamide gel electrophoresis suggested that Mn-SOD activity is higher in B16F1 cells.	Acrylamide	0-10	superoxide dismutase 2, mitochondrial	Mus musculus	46-52
1940019-2	1991	Histochemical studies showed that acrylamide caused different degrees of damage to different nerve fibre types: calcitonin gene-related peptide (CGRP)-immunoreactive (IR) nerves showed the greatest reduction in intensity and number; noradrenaline (NA)-containing nerves were somewhat less affected; substance P (SP)-IR nerves were reduced in number, but this was not significant.	Acrylamide	34-44	calcitonin-related polypeptide alpha	Rattus norvegicus	112-143
1940019-2	1991	Histochemical studies showed that acrylamide caused different degrees of damage to different nerve fibre types: calcitonin gene-related peptide (CGRP)-immunoreactive (IR) nerves showed the greatest reduction in intensity and number; noradrenaline (NA)-containing nerves were somewhat less affected; substance P (SP)-IR nerves were reduced in number, but this was not significant.	Acrylamide	34-44	calcitonin-related polypeptide alpha	Rattus norvegicus	145-149
2029538-1	1991	The technique of fluorescence quenching by the non-ionic quenchers acrylamide and nicotinamide has been used to probe the accessibility of the environmentally sensitive N-(bromoacetyl)-N"-(1-sulpho-5-naphthyl) ethylenediamine (1,5-Br-AEDANS) fluorophore attached to either Cys-177 of the A1-light chain or the SH1 thiol (Cys-707) of the myosin subfragment (S1) heavy chain.	Acrylamide	67-77	myosin heavy chain 14	Homo sapiens	337-343
1716922-5	1991	The relative mobility of the phospholipase B during electrophoresis in sodium dodecyl sulphate gels was dramatically affected by the percentage of acrylamide and the presence or absence of reducing agents in the gels.	Acrylamide	147-157	phospholipase B1	Rattus norvegicus	29-44
2133091-3	1990	Contradictory results as to the role of cytochrome P-450 mediated metabolism of acrylamide in the induction of neurotoxic effects prompted us to investigate the possible formation of glycidamide, a reactive epoxide metabolite.	Acrylamide	80-90	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	40-56
1879377-1	1991	The present study offers evidence indicating that acrylamide a polar molecule inhibits substrate-binding to P450C-21 in a competitive manner and quenches tryptophanyl fluorescence in bovine adrenocortical microsomes, similar to that in the purified lipid-free enzyme.	Acrylamide	50-60	steroid 21-hydroxylase	Bos taurus	113-116
1979364-2	1990	The entire coding region of the dystrophin mRNA was amplified in 10 sections by reverse transcription and nested polymerase chain reaction, and the products were directly visualised on acrylamide minigels with ethidium staining.	Acrylamide	185-195	dystrophin	Homo sapiens	32-42
33761747-6	2021	In the context of the BTK inhibitor ibrutinib, these electrophiles showed lower intrinsic thiol reactivity than the unsubstituted ibrutinib acrylamide.	Acrylamide	140-150	Bruton tyrosine kinase	Homo sapiens	22-25
2205814-4	1990	The protein bands of the acrylamide gels were divided according to their molecular weights into six groups which have been defined in the literature from tear analyses by electrophoretic techniques and include lysozyme, proteins migrating faster than albumin (PMFA), protein G, albumin, lactoferrin, and other proteins heavier than albumin such as Ig-G and secretory Ig-A.	Acrylamide	25-35	lipocalin 1	Homo sapiens	260-264
2367567-0	1990	The interaction of acrylamide with glyceraldehyde-3-phosphate dehydrogenase.	Acrylamide	19-29	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	35-75
2367567-2	1990	The interaction of acrylamide with rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GPDH) has been investigated in Tris buffer, pH 7.5.	Acrylamide	19-29	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	49-89
2367567-2	1990	The interaction of acrylamide with rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GPDH) has been investigated in Tris buffer, pH 7.5.	Acrylamide	19-29	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	91-95
2367567-3	1990	When GPDH containing about 1 mol NAD per mol of tetramer is incubated with acrylamide (0.01-0.1 M), the tryptophan emission of GPDH, initially quenched by acrylamide, slowly increases to a value exceeding that recorded before the addition of acrylamide.	Acrylamide	75-85	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	5-9
2367567-3	1990	When GPDH containing about 1 mol NAD per mol of tetramer is incubated with acrylamide (0.01-0.1 M), the tryptophan emission of GPDH, initially quenched by acrylamide, slowly increases to a value exceeding that recorded before the addition of acrylamide.	Acrylamide	75-85	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	127-131
2367567-3	1990	When GPDH containing about 1 mol NAD per mol of tetramer is incubated with acrylamide (0.01-0.1 M), the tryptophan emission of GPDH, initially quenched by acrylamide, slowly increases to a value exceeding that recorded before the addition of acrylamide.	Acrylamide	155-165	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	5-9
2367567-3	1990	When GPDH containing about 1 mol NAD per mol of tetramer is incubated with acrylamide (0.01-0.1 M), the tryptophan emission of GPDH, initially quenched by acrylamide, slowly increases to a value exceeding that recorded before the addition of acrylamide.	Acrylamide	155-165	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	127-131
2367567-3	1990	When GPDH containing about 1 mol NAD per mol of tetramer is incubated with acrylamide (0.01-0.1 M), the tryptophan emission of GPDH, initially quenched by acrylamide, slowly increases to a value exceeding that recorded before the addition of acrylamide.	Acrylamide	155-165	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	5-9
2367567-3	1990	When GPDH containing about 1 mol NAD per mol of tetramer is incubated with acrylamide (0.01-0.1 M), the tryptophan emission of GPDH, initially quenched by acrylamide, slowly increases to a value exceeding that recorded before the addition of acrylamide.	Acrylamide	155-165	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	127-131
2367567-4	1990	This effect is not observed in apoenzyme solutions, indicating that the enhancement of fluorescence results from the dissociation of some NAD from the acrylamide treated GPDH.	Acrylamide	151-161	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	170-174
2367567-5	1990	Acrylamide inactivates GPDH but 1 mM NAD protects the enzyme from inactivation.	Acrylamide	0-10	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	23-27
1706224-1	1990	Treatment of PtK1 cells with 5 mM acrylamide for 4 hr induces reversible dephosphorylation of keratin in concert with reversible aggregation of intermediate filaments (Eckert and Yeagle, Cell Motil.	Acrylamide	34-44	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	13-17
1706224-3	1990	We have examined this phenomenon by 1) in vitro phosphorylation of isolated PtK1 keratin filaments and 2) combined treatments of PtK1 cells with both acrylamide and agents which elevate intracellular cAMP levels.	Acrylamide	150-160	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	76-80
1706224-3	1990	We have examined this phenomenon by 1) in vitro phosphorylation of isolated PtK1 keratin filaments and 2) combined treatments of PtK1 cells with both acrylamide and agents which elevate intracellular cAMP levels.	Acrylamide	150-160	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	129-133
1706224-13	1990	These observations suggest that 1) PtK1 keratins are phosphorylated by cAMP-dependent kinase and an endogenous, cAMP-independent kinase and 2) alteration of levels of cAMP-dependent phosphorylation may be involved in aggregation of keratin filaments in response to acrylamide.	Acrylamide	265-275	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	35-39
2400913-0	1990	The effect of acrylamide on the induction of ornithine decarboxylase in the dorsal root ganglion of the rat.	Acrylamide	14-24	ornithine decarboxylase 1	Rattus norvegicus	45-68
2400913-3	1990	In order to confirm the relationship between altered axonal transport and ODC induction we treated rats with acrylamide i.p.	Acrylamide	109-119	ornithine decarboxylase 1	Rattus norvegicus	74-77
2367567-6	1990	The addition of acrylamide to GPDH, labeled with fluorescein-5-isothiocyanate (GPDH-FITC) increases the fluorescence and decreases the polarization of fluorescein.	Acrylamide	16-26	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	30-34
2367567-6	1990	The addition of acrylamide to GPDH, labeled with fluorescein-5-isothiocyanate (GPDH-FITC) increases the fluorescence and decreases the polarization of fluorescein.	Acrylamide	16-26	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	79-83
2367567-8	1990	This reagent, however, fails to react with GPDH preincubated with acrylamide and the titration of acrylamide treated GPDH with the sulfhydryl reagent 5,5"-dithiobis(2-nitrobenzoic acid) indicates the loss of up to 7 cysteine residues per tetramer.	Acrylamide	98-108	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	117-121
2367567-9	1990	Acrylamide also decreases the heat stability of GPDH.	Acrylamide	0-10	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	48-52
2367567-10	1990	Altogether, the data indicate that acrylamide covalently reacts with the active site cysteine residues of GPDH and subsequently induces a conformational change in the enzyme.	Acrylamide	35-45	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	106-110
2150904-3	1990	Moreover, quenching of the ATPase intrinsic fluorescence by acrylamide indicated that, depending on the enzyme conformational status, the accessibility of its tryptophan residues is influenced by direct interaction with CaM at micromolar Ca2+ concentration.	Acrylamide	60-70	dynein axonemal heavy chain 8	Homo sapiens	27-33
4190683-0	1969	Demonstration of inherited ceruloplasmin variants in human Serum by acrylamide electrophoresis.	Acrylamide	68-78	ceruloplasmin	Homo sapiens	27-40
33588031-0	2021	Vitamin E and 5-amino salicylic acid ameliorates acrylamide-induced peripheral neuropathy by inhibiting caspase-3 and inducible nitric oxide synthase immunoexpression.	Acrylamide	49-59	caspase 3	Rattus norvegicus	104-113
33588031-0	2021	Vitamin E and 5-amino salicylic acid ameliorates acrylamide-induced peripheral neuropathy by inhibiting caspase-3 and inducible nitric oxide synthase immunoexpression.	Acrylamide	49-59	nitric oxide synthase 2	Rattus norvegicus	118-149
33588031-13	2021	Abnormal gait score was also recorded in acrylamide rats with significant improvement in Vit.	Acrylamide	41-51	vitrin	Rattus norvegicus	89-92
33588031-25	2021	E and 5-ASA protect against acrylamide-induced peripheral neuropathy through downregulation of both caspase-3 and iNOS immunoexpression.	Acrylamide	28-38	caspase 3	Rattus norvegicus	100-109
33588031-25	2021	E and 5-ASA protect against acrylamide-induced peripheral neuropathy through downregulation of both caspase-3 and iNOS immunoexpression.	Acrylamide	28-38	nitric oxide synthase 2	Rattus norvegicus	114-118
33802998-5	2021	We found that the urokinase-type plasminogen activator (uPA) substrate, end-modified with acrylamide groups at sufficient distances from the enzymatic cleavage site, can be successfully used as a cleavable crosslinker of SAP.	Acrylamide	90-100	plasminogen activator, urokinase	Homo sapiens	18-54
33809276-0	2021	Simultaneously Mitigation of Acrylamide, 5-Hydroxymethylfurfural, and Oil Content in Fried Dough Twist via Different Ingredients Combination and Infrared-Assisted Deep-Frying.	Acrylamide	29-39	twist family bHLH transcription factor 1	Homo sapiens	97-102
34896750-3	2022	In this study, seven BTK-inhibitor drugs containing acrylamide warheads were incubated with human serum albumin (HSA) and analyzed using an LC-MS/MS peptide mapping approach to determine the amino acid sites of drug covalent binding.	Acrylamide	52-62	Bruton tyrosine kinase	Homo sapiens	21-24
34416489-0	2022	MiR-27a-5p regulates acrylamide-induced mitochondrial dysfunction and intrinsic apoptosis via targeting Btf3 in rats.	Acrylamide	21-31	microRNA 27a	Rattus norvegicus	0-7
34416489-0	2022	MiR-27a-5p regulates acrylamide-induced mitochondrial dysfunction and intrinsic apoptosis via targeting Btf3 in rats.	Acrylamide	21-31	basic transcription factor 3	Rattus norvegicus	104-108
34896238-6	2022	Moreover, ACR exposure significantly increased levels of MDA and COX-2), decreased GSH level and antioxidant enzyme activity (SOD, GSH-PX and CAT) by downregulating expression of Nrf2 and Keap1 in diabetic mice.	Acrylamide	10-13	cytochrome c oxidase II, mitochondrial	Mus musculus	65-70
34896238-6	2022	Moreover, ACR exposure significantly increased levels of MDA and COX-2), decreased GSH level and antioxidant enzyme activity (SOD, GSH-PX and CAT) by downregulating expression of Nrf2 and Keap1 in diabetic mice.	Acrylamide	10-13	catalase	Mus musculus	142-145
34896238-6	2022	Moreover, ACR exposure significantly increased levels of MDA and COX-2), decreased GSH level and antioxidant enzyme activity (SOD, GSH-PX and CAT) by downregulating expression of Nrf2 and Keap1 in diabetic mice.	Acrylamide	10-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	179-183
34896238-6	2022	Moreover, ACR exposure significantly increased levels of MDA and COX-2), decreased GSH level and antioxidant enzyme activity (SOD, GSH-PX and CAT) by downregulating expression of Nrf2 and Keap1 in diabetic mice.	Acrylamide	10-13	kelch-like ECH-associated protein 1	Mus musculus	188-193
34742913-2	2022	l-Asparaginase helps in removing acrylamide found in fried and baked foods that is carcinogenic in nature.	Acrylamide	33-43	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
34906654-5	2022	The expression levels of Hsd3b1, Cyp11a1 and Star mRNA markedly reduced in acrylamide-treated ovaries.	Acrylamide	75-85	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Mus musculus	25-31
34906654-5	2022	The expression levels of Hsd3b1, Cyp11a1 and Star mRNA markedly reduced in acrylamide-treated ovaries.	Acrylamide	75-85	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	33-40
34906654-5	2022	The expression levels of Hsd3b1, Cyp11a1 and Star mRNA markedly reduced in acrylamide-treated ovaries.	Acrylamide	75-85	steroidogenic acute regulatory protein	Mus musculus	45-49
34906654-6	2022	Furthermore, acrylamide exposure obviously suppressed the activities of catalase and superoxide dismutase, but increased the levels of H2O2 and malondialdehyde.	Acrylamide	13-23	catalase	Mus musculus	72-80
34906654-7	2022	Additionally, acrylamide treatment significantly inhibited luteal angiogenesis and induced the apoptosis of ovarian cells by up-regulation of P53 and Bax protein and down-regulation of Bcl-2 protein.	Acrylamide	14-24	transformation related protein 53, pseudogene	Mus musculus	142-145
34906654-7	2022	Additionally, acrylamide treatment significantly inhibited luteal angiogenesis and induced the apoptosis of ovarian cells by up-regulation of P53 and Bax protein and down-regulation of Bcl-2 protein.	Acrylamide	14-24	BCL2-associated X protein	Mus musculus	150-153
34906654-7	2022	Additionally, acrylamide treatment significantly inhibited luteal angiogenesis and induced the apoptosis of ovarian cells by up-regulation of P53 and Bax protein and down-regulation of Bcl-2 protein.	Acrylamide	14-24	B cell leukemia/lymphoma 2	Mus musculus	185-190
33802998-5	2021	We found that the urokinase-type plasminogen activator (uPA) substrate, end-modified with acrylamide groups at sufficient distances from the enzymatic cleavage site, can be successfully used as a cleavable crosslinker of SAP.	Acrylamide	90-100	plasminogen activator, urokinase	Homo sapiens	56-59
34668566-11	2021	In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene and xylene were positively associated with alkaline phosphatase (ALP).	Acrylamide	67-77	alkaline phosphatase, placental	Homo sapiens	161-181
34661852-5	2022	Pups with ACR consumption showed signs of neuronal degeneration and reduced Nr4a2 expression.	Acrylamide	10-13	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	76-81
34661852-6	2022	On the other hand, pups with ACR + DC consumption showed relative signs of neuronal restoration and enhanced Nr4a2 expression.	Acrylamide	29-32	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	109-114
34668566-11	2021	In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene and xylene were positively associated with alkaline phosphatase (ALP).	Acrylamide	67-77	alkaline phosphatase, placental	Homo sapiens	183-186
34851334-8	2021	Conclusion: The ratio of glycidamide and acrylamide (HbGA/HbAA) was associated with COPD.	Acrylamide	41-51	hemoglobin subunit gamma 1	Homo sapiens	53-57
34174194-7	2021	Application against an existing SARS-CoV Mpro reversible inhibitor led to an acrylamide inhibitor series with low micromolar IC50 values against SARS-CoV-2 Mpro.	Acrylamide	77-87	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	41-45
34174194-7	2021	Application against an existing SARS-CoV Mpro reversible inhibitor led to an acrylamide inhibitor series with low micromolar IC50 values against SARS-CoV-2 Mpro.	Acrylamide	77-87	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	156-160
34783530-8	2021	Acrylamide quenching of the tryptophan fluorescence of Y310W-tau, 1-anilino-8-naphthalene sulfonate (ANS) fluorescence experiment, and far-UV circular dichroism analysis indicated that Fe3+ decreased the solvent exposure of the tryptophan residue, perturbed the hydrophobic surface arrangement, and disrupted the secondary structure of tau, respectively.	Acrylamide	0-10	microtubule associated protein tau	Homo sapiens	61-64
34783530-8	2021	Acrylamide quenching of the tryptophan fluorescence of Y310W-tau, 1-anilino-8-naphthalene sulfonate (ANS) fluorescence experiment, and far-UV circular dichroism analysis indicated that Fe3+ decreased the solvent exposure of the tryptophan residue, perturbed the hydrophobic surface arrangement, and disrupted the secondary structure of tau, respectively.	Acrylamide	0-10	microtubule associated protein tau	Homo sapiens	336-339
34715575-4	2021	KP-14 bound to KRAS G12C through the acrylamide warhead and recruited the E3 ligase CRBN, causing rapid and sustained KRAS G12C degradation which led to suppression of MAPK signaling pathway in NCI-H358 cells.	Acrylamide	37-47	KRAS proto-oncogene, GTPase	Homo sapiens	15-19
34561000-3	2021	In the opaque PPy@CNF suspension, acrylamide monomers (AM) were dissolved and radical-polymerized to construct the PPy@CNF-PAM hydrogel with the in-situ formation of PPy nanofibrils in the presence of excess ammonium persulfate (APS).	Acrylamide	34-44	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	123-126
34817026-1	2021	PURPOSE: Reactive oxygen species (ROS), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) have been shown in the pathogenesis of acrylamide neurotoxicity.	Acrylamide	152-162	interleukin 1 beta	Rattus norvegicus	40-57
34569336-9	2021	Moreover, ACR exposure increased LC3-positive signals, early apoptosis rate, aberrant ATG3, ATG5, LC3, Beclin1, and mTOR mRNA expression.	Acrylamide	10-13	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	33-36
34569336-9	2021	Moreover, ACR exposure increased LC3-positive signals, early apoptosis rate, aberrant ATG3, ATG5, LC3, Beclin1, and mTOR mRNA expression.	Acrylamide	10-13	autophagy related 3	Mus musculus	86-90
34569336-9	2021	Moreover, ACR exposure increased LC3-positive signals, early apoptosis rate, aberrant ATG3, ATG5, LC3, Beclin1, and mTOR mRNA expression.	Acrylamide	10-13	autophagy related 5	Mus musculus	92-96
34569336-9	2021	Moreover, ACR exposure increased LC3-positive signals, early apoptosis rate, aberrant ATG3, ATG5, LC3, Beclin1, and mTOR mRNA expression.	Acrylamide	10-13	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	98-101
34569336-9	2021	Moreover, ACR exposure increased LC3-positive signals, early apoptosis rate, aberrant ATG3, ATG5, LC3, Beclin1, and mTOR mRNA expression.	Acrylamide	10-13	beclin 1, autophagy related	Mus musculus	103-110
34569336-9	2021	Moreover, ACR exposure increased LC3-positive signals, early apoptosis rate, aberrant ATG3, ATG5, LC3, Beclin1, and mTOR mRNA expression.	Acrylamide	10-13	mechanistic target of rapamycin kinase	Mus musculus	116-120
34747428-0	2021	Procyanidin A1 and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway.	Acrylamide	50-60	myosin light chain kinase	Homo sapiens	122-126
34747428-4	2021	Our findings show that both A1 and D-A1 significantly increased the transepithelial electrical resistance (TEER) value; decreased FITC-dextran 4 kDa (FITC-4 kDa) permeability, apoptosis and lactic dehydrogenase (LDH) release; and enhanced the expression of claudin-1, occludin and zonula occludens-1 (ZO-1) in ACR-induced Caco-2 cell monolayer membrane.	Acrylamide	310-313	tight junction protein 1	Homo sapiens	281-299
34747428-4	2021	Our findings show that both A1 and D-A1 significantly increased the transepithelial electrical resistance (TEER) value; decreased FITC-dextran 4 kDa (FITC-4 kDa) permeability, apoptosis and lactic dehydrogenase (LDH) release; and enhanced the expression of claudin-1, occludin and zonula occludens-1 (ZO-1) in ACR-induced Caco-2 cell monolayer membrane.	Acrylamide	310-313	tight junction protein 1	Homo sapiens	301-305
34747428-6	2021	Finally, A1 and D-A1 inhibited the myosin light chain kinase (MLCK) signaling pathway, thereby maintaining normal intestinal barrier functions, similar to the MLCK inhibitor in ACR-induced Caco-2 cell monolayer membrane.	Acrylamide	177-180	myosin light chain kinase	Homo sapiens	159-163
34747428-7	2021	These findings indicate that A1 can alleviate ACR-induced intestinal barrier dysfunction via inhibiting the MAPK/MLCK signaling pathway, and it still has excellent inhibitory effects after digestion.	Acrylamide	46-49	myosin light chain kinase	Homo sapiens	113-117
34817026-1	2021	PURPOSE: Reactive oxygen species (ROS), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) have been shown in the pathogenesis of acrylamide neurotoxicity.	Acrylamide	152-162	interleukin 1 alpha	Rattus norvegicus	59-67
34817026-1	2021	PURPOSE: Reactive oxygen species (ROS), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) have been shown in the pathogenesis of acrylamide neurotoxicity.	Acrylamide	152-162	tumor necrosis factor	Rattus norvegicus	73-100
34817026-1	2021	PURPOSE: Reactive oxygen species (ROS), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) have been shown in the pathogenesis of acrylamide neurotoxicity.	Acrylamide	152-162	tumor necrosis factor	Rattus norvegicus	102-111
34147750-4	2021	EXPERIMENTS: The effect of a water-soluble monomer (acrylamide) on the structure and rheological properties of giant WLMs of an anionic surfactant potassium oleate at different salt content was investigated by combined experimental (SANS, rheometry, fluorescence and NMR spectroscopy, tensiometry) and molecular dynamics simulations studies.	Acrylamide	52-62	USH1 protein network component sans	Homo sapiens	233-237
34761522-3	2022	Here, polyacrylamide/copper-alginate double network (PAM/Cu-alg DN) hydrogel electrolyte was successfully synthesized by radiation-induced polymerization and cross-linking process of acrylamide with N, N"-methylene-bis-acrylamide and subsequent cupric ion (Cu2+ ) crosslinking of alginate.	Acrylamide	183-193	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-56
34117542-1	2021	This study was aimed at elucidating the protective effects of 18beta-glycyrrhetinic acid (18betaGA) against acrylamide (Acr)-induced cellular damage in diabetic rats.	Acrylamide	108-118	acrosin	Rattus norvegicus	120-123
34120280-7	2021	Furthermore, ACR exposure increased hydroxy deoxyguanosine (8-OHdG), tumor necrosis factor-alpha (TNF-alpha), and amyloid protein (AB1-42).	Acrylamide	13-16	tumor necrosis factor	Rattus norvegicus	69-96
34120280-7	2021	Furthermore, ACR exposure increased hydroxy deoxyguanosine (8-OHdG), tumor necrosis factor-alpha (TNF-alpha), and amyloid protein (AB1-42).	Acrylamide	13-16	tumor necrosis factor	Rattus norvegicus	98-107
34120280-8	2021	Finally, the mRNA transcripts of brain Keap-1, Nrf2, and NF-kB were upregulated after ACR intoxication.	Acrylamide	86-89	Kelch-like ECH-associated protein 1	Rattus norvegicus	39-45
34120280-8	2021	Finally, the mRNA transcripts of brain Keap-1, Nrf2, and NF-kB were upregulated after ACR intoxication.	Acrylamide	86-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	47-51
34120280-8	2021	Finally, the mRNA transcripts of brain Keap-1, Nrf2, and NF-kB were upregulated after ACR intoxication.	Acrylamide	86-89	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	57-62
34661844-6	2022	After adjusting for potentially confounding factors, vitamin D had strong negative associations with serum concentrations of acrylamide hemoglobin adducts (HbAA, HbGA, and HbAA + HbGA).	Acrylamide	125-135	hemoglobin subunit gamma 1	Homo sapiens	162-166
34771226-6	2021	When the mass ratio of acrylamide to acrylic acid is 1:2, the obtained P(AM-co-AA) endows the resulting flame-retardant hydrogel applied in fireproof glass with the lowest light transmittance of 81.3% and lowest backside temperature of 131.4  C at 60 min among the samples, which is attributed to the formation of a more dense and expanded char to prevent the heat transfer during combustion, as supported by the digital photos of char residues.	Acrylamide	23-33	ribonuclease P/MRP subunit p21	Homo sapiens	243-250
34771226-9	2021	Especially, when the mass ratio of acrylamide to acrylic acid in P(AM-co-AA) is 4:1, the resulting transparent flame-retardant hydrogel shows a light transmittance of 82.9% and backside temperature of 173.1  C at 60 min after 7 aging cycles, exhibiting the best comprehensive properties among the samples.	Acrylamide	35-45	ribonuclease P/MRP subunit p21	Homo sapiens	208-215
34661844-6	2022	After adjusting for potentially confounding factors, vitamin D had strong negative associations with serum concentrations of acrylamide hemoglobin adducts (HbAA, HbGA, and HbAA + HbGA).	Acrylamide	125-135	hemoglobin subunit gamma 1	Homo sapiens	179-183
34491037-1	2021	The dynamics and structure of water in polyacrylamide hydrogels (PAAm-HG), polyacrylamide, and acrylamide solutions are investigated using ultrafast infrared experiments on the OD stretch of dilute HOD/H2O and molecular dynamics simulations.	Acrylamide	95-105	HOP homeobox	Homo sapiens	198-201
34551652-5	2021	Moreover, ACR induced U87-MG cell apoptosis and autophagy via ROS-triggered expression in the mitochondrial apoptosis pathway, NF-kappaB activation, and autophagosome accumulation.	Acrylamide	10-13	nuclear factor kappa B subunit 1	Homo sapiens	127-136
34868254-3	2021	When the organoids were exposed to foodborne carcinogens-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) and acrylamide (AA)-in the presence of metabolic activation systems, mutation frequencies (MFs) occurring in the gpt gene dose-dependently increased.	Acrylamide	116-126	glutamic pyruvic transaminase, soluble	Mus musculus	225-228
34605515-4	2021	The sensing principle of the microcapsular biosensor is based on the competitive sequence displacement of target miR-141 with the bridging DNA in the microcapsule"s shell, leading to the unlocking of DNA-acrylamide hydrogel microcapsules and the release of the readout signal provided by fluorescent quantum dots.	Acrylamide	204-214	microRNA 141	Homo sapiens	113-120
34605515-6	2021	While miR-141 was directly measured by DNA-acrylamide hydrogel microcapsules, the linear range for the detection of miR-141 is 2.5 to 50 muM and the limit of detection is 1.69 muM.	Acrylamide	43-53	microRNA 141	Homo sapiens	6-13
34605515-6	2021	While miR-141 was directly measured by DNA-acrylamide hydrogel microcapsules, the linear range for the detection of miR-141 is 2.5 to 50 muM and the limit of detection is 1.69 muM.	Acrylamide	43-53	microRNA 141	Homo sapiens	116-123
34636023-7	2021	Substructures such as anilinopyrimidine, acrylamide, amino phenyl, methoxy phenyl, and thienopyrimidinyl amide appeared more in highly active inhibitors against double-mutant EGFR.	Acrylamide	41-51	epidermal growth factor receptor	Homo sapiens	175-179
34625024-9	2021	Inflammation was also a key transcriptomic response to acrylamide, with the cytokine, Colony stimulating factor 2 (Csf2) identified as a top-ranked upstream driver and inflammatory mediator associated with recovery of homeostasis.	Acrylamide	55-65	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	86-113
34625024-9	2021	Inflammation was also a key transcriptomic response to acrylamide, with the cytokine, Colony stimulating factor 2 (Csf2) identified as a top-ranked upstream driver and inflammatory mediator associated with recovery of homeostasis.	Acrylamide	55-65	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	115-119
34625024-11	2021	Additionally, acrylamide treatment led to subtle changes in the expression of genes that encode proteins secreted by the seminal vesicle, including the complement regulator, Complement factor b (Cfb).	Acrylamide	14-24	complement factor B	Mus musculus	174-193
34625024-11	2021	Additionally, acrylamide treatment led to subtle changes in the expression of genes that encode proteins secreted by the seminal vesicle, including the complement regulator, Complement factor b (Cfb).	Acrylamide	14-24	complement factor B	Mus musculus	195-198
34606550-4	2021	PA exhibited the strongest inhibition activity for protein glycation products, and the content of 5-HMF and acrylamide decreased from 277.44 and 10.60 mug mL-1 to 208.37 and 5.46 mug mL-1, respectively, at 30.08 x 10-5 M compared with the control group.	Acrylamide	108-118	L1 cell adhesion molecule	Mus musculus	155-159
34606550-4	2021	PA exhibited the strongest inhibition activity for protein glycation products, and the content of 5-HMF and acrylamide decreased from 277.44 and 10.60 mug mL-1 to 208.37 and 5.46 mug mL-1, respectively, at 30.08 x 10-5 M compared with the control group.	Acrylamide	108-118	L1 cell adhesion molecule	Mus musculus	183-187
34399322-0	2021	Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC).	Acrylamide	17-27	epidermal growth factor receptor	Homo sapiens	83-87
34399322-4	2021	In an attempt to develop potent and selective EGFR T790M inhibitors, we have designed and synthesized two series of novel acrylamide linked quinazolines.	Acrylamide	122-132	epidermal growth factor receptor	Homo sapiens	46-50
34120003-8	2021	CONCLUSIONS: A decrease in cord plasma insulin levels may be (a marker of) a mechanism by which gestational acrylamide exposure is associated with decreased fetal growth.	Acrylamide	108-118	insulin	Homo sapiens	39-46
34509579-10	2021	AChE staining showed that the number of MEPs was significantly reduced after exposure to ACR, the shape became small, and the AChE content decreased in a dose-dependent manner.	Acrylamide	89-92	acetylcholinesterase	Rattus norvegicus	0-4
34509579-10	2021	AChE staining showed that the number of MEPs was significantly reduced after exposure to ACR, the shape became small, and the AChE content decreased in a dose-dependent manner.	Acrylamide	89-92	acetylcholinesterase	Rattus norvegicus	126-130
34509579-11	2021	Immunohistochemistry and western blot analysis results of the expression levels of AchE and CGRP showed a decreasing trend as compared to the control group with increasing ACR exposure dose.	Acrylamide	172-175	calcitonin-related polypeptide alpha	Rattus norvegicus	92-96
34450424-8	2021	The results of Western blot showed that ACR treatment elevated protein levels of Beclin1, LC3-II/LC3-I, p-PERK/t-PERK, ATF4 and CHOP, indicating the initiation of autophagy, the activation of PERK pathway in ERS.	Acrylamide	40-43	beclin 1	Rattus norvegicus	81-88
34574293-0	2021	HS-SPME Gas Chromatography Approach for Underivatized Acrylamide Determination in Biscuits.	Acrylamide	54-64	gastrin	Homo sapiens	8-11
34511841-5	2021	In this study, we developed an integrated hollow core-shell-shell hydrogel tube of gelatin/alginate/acrylamide-bacterial nanocellulose(GAA) that meets the anticoagulant requirements for the inner tubing layer as well as the highly elastic soft material needed for the outer layer.	Acrylamide	100-110	alpha glucosidase	Homo sapiens	135-138
34450424-8	2021	The results of Western blot showed that ACR treatment elevated protein levels of Beclin1, LC3-II/LC3-I, p-PERK/t-PERK, ATF4 and CHOP, indicating the initiation of autophagy, the activation of PERK pathway in ERS.	Acrylamide	40-43	activating transcription factor 4	Rattus norvegicus	119-123
34450424-8	2021	The results of Western blot showed that ACR treatment elevated protein levels of Beclin1, LC3-II/LC3-I, p-PERK/t-PERK, ATF4 and CHOP, indicating the initiation of autophagy, the activation of PERK pathway in ERS.	Acrylamide	40-43	DNA-damage inducible transcript 3	Rattus norvegicus	128-132
34443616-6	2021	beta-CD-methacrylate, which could function as a crosslinker, was then copolymerized with acrylamide monomer via free-radical copolymerization to form beta-CD-polyacrylamide (beta-CD-PAAm) hydrogel.	Acrylamide	89-99	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	0-7
34243628-6	2021	In the acrylamide group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) levels were found to be high, total glutathione (tGSH) levels were found to be low, and there was severe interstitial haemorrhage; additionally, tubular necrosis, tubular atrophy, leucocyte infiltration, and glomerular structures with expanded Bowman"s space were observed.	Acrylamide	7-17	tumor necrosis factor	Rattus norvegicus	78-87
34191505-5	2021	Furthermore, acrylamide decreased the expression of mitochondrial biogenesis- and dynamics-related genes, including PGC-1alpha, TFAM, Mfn2, and Opa1, and altered the expression of mitochondrial DNA (mtDNA)-encoded mitochondrial respiratory chain complexes, along with the inhibited mitochondrial respiration.	Acrylamide	13-23	PPARG coactivator 1 alpha	Rattus norvegicus	116-126
34191505-5	2021	Furthermore, acrylamide decreased the expression of mitochondrial biogenesis- and dynamics-related genes, including PGC-1alpha, TFAM, Mfn2, and Opa1, and altered the expression of mitochondrial DNA (mtDNA)-encoded mitochondrial respiratory chain complexes, along with the inhibited mitochondrial respiration.	Acrylamide	13-23	transcription factor A, mitochondrial	Rattus norvegicus	128-132
34191505-5	2021	Furthermore, acrylamide decreased the expression of mitochondrial biogenesis- and dynamics-related genes, including PGC-1alpha, TFAM, Mfn2, and Opa1, and altered the expression of mitochondrial DNA (mtDNA)-encoded mitochondrial respiratory chain complexes, along with the inhibited mitochondrial respiration.	Acrylamide	13-23	mitofusin 2	Rattus norvegicus	134-138
34191505-5	2021	Furthermore, acrylamide decreased the expression of mitochondrial biogenesis- and dynamics-related genes, including PGC-1alpha, TFAM, Mfn2, and Opa1, and altered the expression of mitochondrial DNA (mtDNA)-encoded mitochondrial respiratory chain complexes, along with the inhibited mitochondrial respiration.	Acrylamide	13-23	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	144-148
34191505-7	2021	Further in vivo experiments confirmed that acrylamide decreased the expressions of PGC-1alpha, TFAM, Mfn2, and Opa1 in rat brain tissues.	Acrylamide	43-53	PPARG coactivator 1 alpha	Rattus norvegicus	83-93
34191505-7	2021	Further in vivo experiments confirmed that acrylamide decreased the expressions of PGC-1alpha, TFAM, Mfn2, and Opa1 in rat brain tissues.	Acrylamide	43-53	transcription factor A, mitochondrial	Rattus norvegicus	95-99
34191505-7	2021	Further in vivo experiments confirmed that acrylamide decreased the expressions of PGC-1alpha, TFAM, Mfn2, and Opa1 in rat brain tissues.	Acrylamide	43-53	mitofusin 2	Rattus norvegicus	101-105
34191505-7	2021	Further in vivo experiments confirmed that acrylamide decreased the expressions of PGC-1alpha, TFAM, Mfn2, and Opa1 in rat brain tissues.	Acrylamide	43-53	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	111-115
34233550-11	2021	Acrylamide induced oxidative stress, testicular NF-kappaB/p65 expression, and down-regulated the expression of occludin, all of which can contribute to its testicular toxicity, while TQ or capsaicin removes all of these toxicity signs.	Acrylamide	0-10	synaptotagmin 1	Rattus norvegicus	58-61
34233550-11	2021	Acrylamide induced oxidative stress, testicular NF-kappaB/p65 expression, and down-regulated the expression of occludin, all of which can contribute to its testicular toxicity, while TQ or capsaicin removes all of these toxicity signs.	Acrylamide	0-10	occludin	Rattus norvegicus	111-119
34243628-6	2021	In the acrylamide group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) levels were found to be high, total glutathione (tGSH) levels were found to be low, and there was severe interstitial haemorrhage; additionally, tubular necrosis, tubular atrophy, leucocyte infiltration, and glomerular structures with expanded Bowman"s space were observed.	Acrylamide	7-17	interleukin 1 beta	Rattus norvegicus	94-112
34243628-6	2021	In the acrylamide group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) levels were found to be high, total glutathione (tGSH) levels were found to be low, and there was severe interstitial haemorrhage; additionally, tubular necrosis, tubular atrophy, leucocyte infiltration, and glomerular structures with expanded Bowman"s space were observed.	Acrylamide	7-17	interleukin 1 alpha	Rattus norvegicus	114-122
34243628-8	2021	This suggests that Taxifolin would prevent kidney tissue from acrylamide-induced damage would be effective in treating acrylamide-induced nephrotoxicity, inhibiting the increase of MDA, IL-1beta and TNF-alpha, and decreasing tGSH associated with acrylamide.	Acrylamide	62-72	interleukin 1 alpha	Rattus norvegicus	186-194
34243628-8	2021	This suggests that Taxifolin would prevent kidney tissue from acrylamide-induced damage would be effective in treating acrylamide-induced nephrotoxicity, inhibiting the increase of MDA, IL-1beta and TNF-alpha, and decreasing tGSH associated with acrylamide.	Acrylamide	62-72	tumor necrosis factor	Rattus norvegicus	199-208
34107465-0	2021	Evaluation of acrylamide-based molecularly imprinted polymer thin-sheets for specific protein capture - a myoglobin model.	Acrylamide	14-24	myoglobin	Homo sapiens	106-115
34107465-1	2021	We evaluate a series of thin-sheet hydrogel molecularly imprinted polymers (MIPs), using a family of acrylamide-based monomers, selective for the target protein myoglobin (Mb).	Acrylamide	101-111	myoglobin	Homo sapiens	161-170
34107465-1	2021	We evaluate a series of thin-sheet hydrogel molecularly imprinted polymers (MIPs), using a family of acrylamide-based monomers, selective for the target protein myoglobin (Mb).	Acrylamide	101-111	myoglobin	Homo sapiens	172-174
34206048-0	2021	Nrf2 Activation Attenuates Acrylamide-Induced Neuropathy in Mice.	Acrylamide	27-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
35364817-5	2022	Acrylamide increased reactive oxygen species and malondialdehyde formation and reduced glutathione levels, catalase, and total antioxidant capacity activity, which caused a succession of events associated with oxidative damage, including glial cell activation.	Acrylamide	0-10	catalase	Rattus norvegicus	107-115
35381387-7	2022	Acrylamide, a reagent that disrupts vimentin intermediate filaments, prevented histamine/OS-induced SNAP23 translocation, as well as VWF secretion.	Acrylamide	0-10	vimentin	Homo sapiens	36-44
35381387-7	2022	Acrylamide, a reagent that disrupts vimentin intermediate filaments, prevented histamine/OS-induced SNAP23 translocation, as well as VWF secretion.	Acrylamide	0-10	synaptosome associated protein 23	Homo sapiens	100-106
35381387-7	2022	Acrylamide, a reagent that disrupts vimentin intermediate filaments, prevented histamine/OS-induced SNAP23 translocation, as well as VWF secretion.	Acrylamide	0-10	von Willebrand factor	Homo sapiens	133-136
35088269-6	2022	Moreover, ACR caused neurological defects associated with gait abnormality and neuronal loss while suppressing the acetylcholine (ACh) and dopamine (DA) levels and increasing the protein expression of alpha-synuclein (alpha-syn), further inhibiting cholinergic and dopaminergic neuronal function.	Acrylamide	10-13	synuclein, alpha	Mus musculus	201-216
35088269-6	2022	Moreover, ACR caused neurological defects associated with gait abnormality and neuronal loss while suppressing the acetylcholine (ACh) and dopamine (DA) levels and increasing the protein expression of alpha-synuclein (alpha-syn), further inhibiting cholinergic and dopaminergic neuronal function.	Acrylamide	10-13	synuclein, alpha	Mus musculus	218-227
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-86
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	NLR family, pyrin domain containing 3	Mus musculus	150-177
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	NLR family, pyrin domain containing 3	Mus musculus	179-184
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	NLR family, pyrin domain containing 3	Mus musculus	215-220
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	PYD and CARD domain containing	Mus musculus	313-368
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	PYD and CARD domain containing	Mus musculus	370-373
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	interleukin 1 beta	Mus musculus	408-425
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	interleukin 1 alpha	Mus musculus	427-435
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	interleukin 18	Mus musculus	442-447
35512804-0	2022	Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A.	Acrylamide	28-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	141-159
35442627-0	2022	Subchronic Acrylamide Exposure Activates PERK-eIF2alpha Signaling Pathway and Induces Synaptic Impairment in Rat Hippocampus.	Acrylamide	11-21	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	41-45
35442627-0	2022	Subchronic Acrylamide Exposure Activates PERK-eIF2alpha Signaling Pathway and Induces Synaptic Impairment in Rat Hippocampus.	Acrylamide	11-21	eukaryotic translation initiation factor 2A	Rattus norvegicus	46-55
35442627-6	2022	The present study is designed to explore the effect of subchronic ACR exposure on the PERK signaling and the synaptic impairment to elucidate the potential mechanism of ACR-induced cognitive dysfunction in rat.	Acrylamide	66-69	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	86-90
35442627-6	2022	The present study is designed to explore the effect of subchronic ACR exposure on the PERK signaling and the synaptic impairment to elucidate the potential mechanism of ACR-induced cognitive dysfunction in rat.	Acrylamide	169-172	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	86-90
35442627-9	2022	ACR also excessively activates the PERK-eIF2alpha signaling, resulting in overexpression of C/EBP homologous protein (CHOP) and activating transcription factor 4 (ATF4).	Acrylamide	0-3	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	35-39
35442627-9	2022	ACR also excessively activates the PERK-eIF2alpha signaling, resulting in overexpression of C/EBP homologous protein (CHOP) and activating transcription factor 4 (ATF4).	Acrylamide	0-3	eukaryotic translation initiation factor 2A	Rattus norvegicus	40-49
35442627-9	2022	ACR also excessively activates the PERK-eIF2alpha signaling, resulting in overexpression of C/EBP homologous protein (CHOP) and activating transcription factor 4 (ATF4).	Acrylamide	0-3	DNA-damage inducible transcript 3	Rattus norvegicus	92-116
35442627-9	2022	ACR also excessively activates the PERK-eIF2alpha signaling, resulting in overexpression of C/EBP homologous protein (CHOP) and activating transcription factor 4 (ATF4).	Acrylamide	0-3	DNA-damage inducible transcript 3	Rattus norvegicus	118-122
35442627-9	2022	ACR also excessively activates the PERK-eIF2alpha signaling, resulting in overexpression of C/EBP homologous protein (CHOP) and activating transcription factor 4 (ATF4).	Acrylamide	0-3	activating transcription factor 4	Rattus norvegicus	128-161
35442627-9	2022	ACR also excessively activates the PERK-eIF2alpha signaling, resulting in overexpression of C/EBP homologous protein (CHOP) and activating transcription factor 4 (ATF4).	Acrylamide	0-3	activating transcription factor 4	Rattus norvegicus	163-167
35247543-4	2022	Remibrutinib is a covalent inhibitor of Bruton"s Tyrosine kinase (BTKi) carrying a reactive acrylamide moiety (warhead), thus the potential contribution of covalent binding (off-target) to observed interactions was investigated as this could lead to prolonged and more potent drug interactions.	Acrylamide	92-102	Bruton tyrosine kinase	Homo sapiens	66-70
35390441-6	2022	Not only that, subsequent cellular responses resulting from methylglyoxal accumulation, such as oxidative stress, activation of ERK, upregulation of NF-kappaB inflammatory signaling pathway, and elevated pro-inflammatory factor TNF-alpha, were found in the acrylamide-treated cell model.	Acrylamide	257-267	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
35390441-6	2022	Not only that, subsequent cellular responses resulting from methylglyoxal accumulation, such as oxidative stress, activation of ERK, upregulation of NF-kappaB inflammatory signaling pathway, and elevated pro-inflammatory factor TNF-alpha, were found in the acrylamide-treated cell model.	Acrylamide	257-267	tumor necrosis factor	Mus musculus	228-237
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	53-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	53-63	tumor necrosis factor	Mus musculus	193-220
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	53-63	tumor necrosis factor	Mus musculus	222-231
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	53-63	nitric oxide synthase 2, inducible	Mus musculus	237-268
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	53-63	nitric oxide synthase 2, inducible	Mus musculus	270-274
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	153-163	tumor necrosis factor	Mus musculus	193-220
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	153-163	tumor necrosis factor	Mus musculus	222-231
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	153-163	nitric oxide synthase 2, inducible	Mus musculus	237-268
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	Acrylamide	153-163	nitric oxide synthase 2, inducible	Mus musculus	270-274
34206048-6	2021	The results demonstrate that activation of the Nrf2 signaling pathway by co-treatment of sulforaphane provides protection against acrylamide-induced neurotoxicity through suppression of oxidative stress and inflammation.	Acrylamide	130-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-51
34206048-7	2021	Nrf2 remains an important target for the strategic prevention of acrylamide-induced neurotoxicity.	Acrylamide	65-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
35486963-0	2022	Acrylamide exposure increases cardiovascular risk of general adult population probably by inducing oxidative stress, inflammation, and TGF-beta1: A prospective cohort study.	Acrylamide	0-10	transforming growth factor beta 1	Homo sapiens	135-144
35486963-7	2022	Furthermore, 8-OHdG, 8-iso-PGF2alpha, MPV, CRP, and TGF-beta1 were found to significantly mediate 8.06-48.92% of the ACR metabolites-associated 10-year CVD risk increment.	Acrylamide	117-120	C-reactive protein	Homo sapiens	43-46
35486963-7	2022	Furthermore, 8-OHdG, 8-iso-PGF2alpha, MPV, CRP, and TGF-beta1 were found to significantly mediate 8.06-48.92% of the ACR metabolites-associated 10-year CVD risk increment.	Acrylamide	117-120	transforming growth factor beta 1	Homo sapiens	52-61
35486963-8	2022	In summary, daily ACR exposure of general adults was cross-sectionally and longitudinally associated with increased cardiovascular risk, which was partly mediated by oxidative stress, inflammation, and TGF-beta1, suggesting for the first time that ACR exposure may well increase cardiovascular risk of general adult population partly by mechanisms of inducing oxidative stress, inflammation, and TGF-beta1.	Acrylamide	18-21	transforming growth factor beta 1	Homo sapiens	202-211
35486963-8	2022	In summary, daily ACR exposure of general adults was cross-sectionally and longitudinally associated with increased cardiovascular risk, which was partly mediated by oxidative stress, inflammation, and TGF-beta1, suggesting for the first time that ACR exposure may well increase cardiovascular risk of general adult population partly by mechanisms of inducing oxidative stress, inflammation, and TGF-beta1.	Acrylamide	18-21	transforming growth factor beta 1	Homo sapiens	396-405
35486963-8	2022	In summary, daily ACR exposure of general adults was cross-sectionally and longitudinally associated with increased cardiovascular risk, which was partly mediated by oxidative stress, inflammation, and TGF-beta1, suggesting for the first time that ACR exposure may well increase cardiovascular risk of general adult population partly by mechanisms of inducing oxidative stress, inflammation, and TGF-beta1.	Acrylamide	248-251	transforming growth factor beta 1	Homo sapiens	202-211
35486963-8	2022	In summary, daily ACR exposure of general adults was cross-sectionally and longitudinally associated with increased cardiovascular risk, which was partly mediated by oxidative stress, inflammation, and TGF-beta1, suggesting for the first time that ACR exposure may well increase cardiovascular risk of general adult population partly by mechanisms of inducing oxidative stress, inflammation, and TGF-beta1.	Acrylamide	248-251	transforming growth factor beta 1	Homo sapiens	396-405
35489137-0	2022	Stimulating the expression of sphingosine kinase 1 (SphK1) is beneficial to reduce acrylamide-induced nerve cell damage.	Acrylamide	83-93	sphingosine kinase 1	Homo sapiens	30-50
35489137-0	2022	Stimulating the expression of sphingosine kinase 1 (SphK1) is beneficial to reduce acrylamide-induced nerve cell damage.	Acrylamide	83-93	sphingosine kinase 1	Homo sapiens	52-57
35489137-3	2022	The purpose of this study was to investigate the role and potential mechanism of SphK1 in ACR-induced nerve injury.	Acrylamide	90-93	sphingosine kinase 1	Homo sapiens	81-86
35489137-7	2022	The results of the population study showed that the contents of SphK1 and S1P in the ACR-exposed occupational contact group were lower than in the non-exposed group.	Acrylamide	85-88	sphingosine kinase 1	Homo sapiens	64-69
35489137-8	2022	The results of in vitro experiments showed that expression of SphK1 decreased with the increase in ACR concentration.	Acrylamide	99-102	sphingosine kinase 1	Homo sapiens	62-67
35489137-11	2022	These results suggest that activating SphK1 can protect against nerve cell damage caused by ACR.	Acrylamide	92-95	sphingosine kinase 1	Homo sapiens	38-43
35398057-3	2022	Herein, we presented a SPI-based polymer electrolyte by grafting modification with the hydrophilic functional monomer acrylamide (AM).	Acrylamide	118-128	chromogranin A	Homo sapiens	23-26
35587148-5	2022	Using the scaffold of the Bruton"s tyrosine kinase (BTK) inhibitor Ibrutinib for our proof-of-concept, we reasoned that increasing the steric bulk of fumarate-based electrophiles on Ibrutinib should improve selectivity via the steric exclusion of off-targets but retain rates of cysteine reactivity comparable to that of an acrylamide.	Acrylamide	324-334	Bruton tyrosine kinase	Homo sapiens	26-50
35587148-5	2022	Using the scaffold of the Bruton"s tyrosine kinase (BTK) inhibitor Ibrutinib for our proof-of-concept, we reasoned that increasing the steric bulk of fumarate-based electrophiles on Ibrutinib should improve selectivity via the steric exclusion of off-targets but retain rates of cysteine reactivity comparable to that of an acrylamide.	Acrylamide	324-334	Bruton tyrosine kinase	Homo sapiens	52-55
35257727-1	2022	Sodium alginate/krill protein/polyacrylamide (SA/AKP/PAM) hydrogel with "covalent bond-ion complex-hydrogen bond" multi-network structure was prepared by covalent cross-linking and complexion ion crosslinking using SA, AKP, and acrylamide (AM) as raw materials.	Acrylamide	228-238	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-56
35512804-7	2022	Finally, utilizing GSH trapping and high-resolution mass spectrometry, we illuminated that while the acrylamide moiety in FUT could nonenzymatically conjugate to GSH via Michael addition, it was not implicated in the covalent inactivation of CYP3A.	Acrylamide	101-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	242-247
35512804-8	2022	Rather, we surmised that it likely stemmed from the metabolic activation of its acrylamide covalent warhead to a highly electrophilic epoxide intermediate that could covalently modify CYP3A and culminate in its catalytic inactivation.	Acrylamide	80-90	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-189
35394754-1	2022	In the present work, a multiple-stimuli-responsive hydrogel has been synthesized via polymerization of acrylamide (AAm) and N-hydroxy methyl acrylamide (HMAm) on beta-cyclodextrin (beta-CD).	Acrylamide	103-113	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	181-188
35394754-1	2022	In the present work, a multiple-stimuli-responsive hydrogel has been synthesized via polymerization of acrylamide (AAm) and N-hydroxy methyl acrylamide (HMAm) on beta-cyclodextrin (beta-CD).	Acrylamide	115-118	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	181-188
35187760-12	2022	Thymoquinone and quercetin not only reduced acrylamide-induced apoptosis in annexin V and caspase 3/7 assays but also morphological deformations in microscopic examinations.	Acrylamide	44-54	annexin A5	Rattus norvegicus	76-85
35187760-12	2022	Thymoquinone and quercetin not only reduced acrylamide-induced apoptosis in annexin V and caspase 3/7 assays but also morphological deformations in microscopic examinations.	Acrylamide	44-54	caspase 3	Rattus norvegicus	90-101
35187760-14	2022	As for Nrf2 expression, it was observed that acrylamide increased Nrf2 expression, and thymoquinone and quercetin pretreatments increased it even further.	Acrylamide	45-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	7-11
35187760-14	2022	As for Nrf2 expression, it was observed that acrylamide increased Nrf2 expression, and thymoquinone and quercetin pretreatments increased it even further.	Acrylamide	45-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-70
35061330-6	2022	We found several chloroacetamide and acrylamide fragments that inhibited Ral GTPase exchange by Rgl2.	Acrylamide	37-47	RAS like proto-oncogene A	Homo sapiens	73-76
35061330-6	2022	We found several chloroacetamide and acrylamide fragments that inhibited Ral GTPase exchange by Rgl2.	Acrylamide	37-47	ral guanine nucleotide dissociation stimulator like 2	Homo sapiens	96-100
35250264-2	2022	Acrylamide is metabolized by the CYP2E1 enzyme in the body to form glycidamides, an epoxide that is reactive to DNA and can form carcinogenic adducts.	Acrylamide	0-10	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	33-39
35250264-11	2022	Theoretically, acrylamide and glycidamide concentration should correlate to each other; however in reality, there are other factors (such as CYP2E1 polymorphism, dietary intake, etc) that can cause variation in their respective concentration.	Acrylamide	15-25	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	141-147
35139711-5	2022	Most studies (69.7%) evaluated acrylamide in bread, cookies, and pasta, while PAHs (26.2%) were determined mainly in wheat grains and pasta.	Acrylamide	31-41	solute carrier family 45 member 1	Homo sapiens	65-70
35295848-7	2022	Further analysis showed that ACR exposure reduced the fluorescence intensity of Rps3 and abnormal distribution of the endoplasmic reticulum, indicating that ACR affected protein synthesis and modification in mouse oocytes.	Acrylamide	29-32	ribosomal protein S3	Mus musculus	80-84
35295848-7	2022	Further analysis showed that ACR exposure reduced the fluorescence intensity of Rps3 and abnormal distribution of the endoplasmic reticulum, indicating that ACR affected protein synthesis and modification in mouse oocytes.	Acrylamide	157-160	ribosomal protein S3	Mus musculus	80-84
35295848-8	2022	We found the negative effects of ACR on the distribution of the Golgi apparatus; in addition, fluorescence intensity of vesicle transporter Rab8A decreased, suggesting the decrease in protein transport capacity of oocytes.	Acrylamide	33-36	RAB8A, member RAS oncogene family	Mus musculus	140-145
35295848-9	2022	Furthermore, the simultaneous increase in lysosomes and LAMP2 fluorescence intensity was also observed, suggesting that ACR affected protein degradation in oocytes.	Acrylamide	120-123	lysosomal-associated membrane protein 2	Mus musculus	56-61
35216144-19	2022	There are many scientific reports indicating the harmful effects of ACR on AChE.	Acrylamide	68-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
35216144-20	2022	Most of them indicate that ACR reduces the concentration and activity of AChE.	Acrylamide	27-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77
35164330-0	2022	AQP4 Attenuated TRAF6/NFkappaB Activation in Acrylamide-Induced Neurotoxicity.	Acrylamide	45-55	aquaporin 4	Rattus norvegicus	0-4
35164330-0	2022	AQP4 Attenuated TRAF6/NFkappaB Activation in Acrylamide-Induced Neurotoxicity.	Acrylamide	45-55	TNF receptor associated factor 6	Rattus norvegicus	16-21
35164330-0	2022	AQP4 Attenuated TRAF6/NFkappaB Activation in Acrylamide-Induced Neurotoxicity.	Acrylamide	45-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-30
35164330-7	2022	Matrix metalloproteinase (MMP9) expression was higher in the ACR-treated group than in the control group.	Acrylamide	61-64	matrix metallopeptidase 9	Rattus norvegicus	26-30
35164330-8	2022	ACR induced MMP-9 and AQP4 protein expression in the brain tissues of the rats, which subsequently presented with neurotoxicity.	Acrylamide	0-3	matrix metallopeptidase 9	Rattus norvegicus	12-17
35164330-8	2022	ACR induced MMP-9 and AQP4 protein expression in the brain tissues of the rats, which subsequently presented with neurotoxicity.	Acrylamide	0-3	aquaporin 4	Rattus norvegicus	22-26
35164231-4	2022	The results showed that acrylamide decreased AChE activity in the examined brain samples by about 25% in comparison to the control group, and this effect was decreased by administering alpha-tocopherol.	Acrylamide	24-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
35164193-1	2022	L-asparaginase (ASNase) is an amidohydrolase that can be used as a biopharmaceutical, as an agent for acrylamide reduction, and as an active molecule for L-asparagine detection.	Acrylamide	102-112	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
35164193-1	2022	L-asparaginase (ASNase) is an amidohydrolase that can be used as a biopharmaceutical, as an agent for acrylamide reduction, and as an active molecule for L-asparagine detection.	Acrylamide	102-112	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-22
35237426-7	2022	On administration of acrylamide for 10 days, neurotoxicity was observed in terms of decreased acetylcholinesterase activity and oxidative stress was observed in terms of increased lipid peroxidation, declined level of reduced glutathione, antioxidant enzymes (superoxide dismutase and catalase) in liver, kidney and brain.	Acrylamide	21-31	catalase	Rattus norvegicus	285-293
3053716-6	1988	Comparative lifetime and acrylamide quenching studies suggest that there are differences in the conformations of apo-CRBP and apo-CRBP II.	Acrylamide	25-35	retinol binding protein 1	Rattus norvegicus	117-121
35164330-10	2022	Using a combination of in vivo and in vitro experiments, this study revealed that depressive symptoms associated with ACR-induced neurotoxicity are associated with downregulation of AQP4 and induction of the TRAF6 pathway.	Acrylamide	118-121	aquaporin 4	Mus musculus	182-186
35164330-10	2022	Using a combination of in vivo and in vitro experiments, this study revealed that depressive symptoms associated with ACR-induced neurotoxicity are associated with downregulation of AQP4 and induction of the TRAF6 pathway.	Acrylamide	118-121	TNF receptor-associated factor 6	Mus musculus	208-213
2684641-2	1989	Like the mammalian factor, the yeast protein does not bind DNA, alters the size of the TFIID DNase I footprint at the adenovirus major late promoter, and forms specific TFIIA-TFIID-DNA complexes which are stable during electrophoresis in native acrylamide gels.	Acrylamide	245-255	general transcription factor IIA subunit 1	Homo sapiens	169-174
2730902-5	1989	This interpretation was further supported by an elevation of the transition temperature of the anisotropy, a decrease in the quenching rate constant of the fluorescence with acrylamide and a decrease in the SH reactivity of the membrane proteins for NPM by lipid peroxidation.	Acrylamide	174-184	nucleophosmin 1	Homo sapiens	250-253
2737261-8	1989	Acrylamide quenching constants for the long-lived components of gamma-II and III were roughly equal, while the short-lived tryptophans of gamma-III were an order of magnitude more accessible than those of gamma-II.	Acrylamide	0-10	G protein subunit gamma 7	Bos taurus	64-72
2707264-2	1989	The enzyme, alcohol dehydrogenase, was first activated, then polypeptide arms of known composition were quantitatively grafted and finally the enzyme was covalently immobilized by co-polymerization of the activated ends of the peptide arms with acrylamide monomers.	Acrylamide	245-255	aldo-keto reductase family 1 member A1	Homo sapiens	12-33
2723544-2	1989	The inhibitory effect of this acylamide was specific for cholesterol esterification catalyzed by ACAT; the rates of triglyceride, phospholipid, and cholesterol synthesis were not inhibited by this agent.	Acrylamide	30-39	sterol O-acyltransferase 1	Homo sapiens	97-101
2706245-4	1989	Quenching experiments with acrylamide are consistent with the view that Trp-89 is exposed in the native protein and becomes less accessible upon formation of the complex with PRI.	Acrylamide	27-37	ribonuclease/angiogenin inhibitor 1	Homo sapiens	175-178
2653644-7	1989	Exposure of the injected cells to nocadazole or acrylamide caused the desmin network to collapse and form a perinuclear cap that was indistinguishable from vimentin caps in the same cells.	Acrylamide	48-58	desmin	Gallus gallus	70-76
35131362-5	2022	By using immunofluorescence, we found that AC (0.5, 1 and 5 mM) induced the formation of both phosphorylated form of the histone H2 variant H2AX (gH2AX) and p53-binding protein 1 (53BP1) foci.	Acrylamide	43-45	H2A.X variant histone	Homo sapiens	140-144
35131362-5	2022	By using immunofluorescence, we found that AC (0.5, 1 and 5 mM) induced the formation of both phosphorylated form of the histone H2 variant H2AX (gH2AX) and p53-binding protein 1 (53BP1) foci.	Acrylamide	43-45	tumor protein p53 binding protein 1	Homo sapiens	157-178
35131362-5	2022	By using immunofluorescence, we found that AC (0.5, 1 and 5 mM) induced the formation of both phosphorylated form of the histone H2 variant H2AX (gH2AX) and p53-binding protein 1 (53BP1) foci.	Acrylamide	43-45	tumor protein p53 binding protein 1	Homo sapiens	180-185
35057627-3	2022	Vinylsulfonamides showed complementary advantages over the well-developed vinylamides or vinylcarbamates for this Rh(II)-catalyzed cyclopropanation strategy.	Acrylamide	74-85	Rh blood group D antigen	Homo sapiens	114-120
34473322-2	2022	This revealed acrylamide-intoxicated control group had significant higher levels of malondialdehyde, tumor necrosis factor-alpha (TNF-alpha), high-sensitive C-reactive protein (hs-CRP), leptin and alanine transaminase, and lower levels of total antioxidant capacity compared to the negative control group.	Acrylamide	14-24	tumor necrosis factor	Rattus norvegicus	130-139
34473322-2	2022	This revealed acrylamide-intoxicated control group had significant higher levels of malondialdehyde, tumor necrosis factor-alpha (TNF-alpha), high-sensitive C-reactive protein (hs-CRP), leptin and alanine transaminase, and lower levels of total antioxidant capacity compared to the negative control group.	Acrylamide	14-24	C-reactive protein	Rattus norvegicus	180-183
34473322-2	2022	This revealed acrylamide-intoxicated control group had significant higher levels of malondialdehyde, tumor necrosis factor-alpha (TNF-alpha), high-sensitive C-reactive protein (hs-CRP), leptin and alanine transaminase, and lower levels of total antioxidant capacity compared to the negative control group.	Acrylamide	14-24	leptin	Rattus norvegicus	186-192
2621691-1	1989	Two isoenzymes of oxytocinase activity were fractionated from human seminal plasma by acrylamide-agarose gel chromatography and partly characterized using S-benzyl-L-cysteine-p-nitroanilide (BCN) and L-leucine-p-nitroanilide (LN) separately as substrates.	Acrylamide	86-96	leucyl and cystinyl aminopeptidase	Homo sapiens	18-29
2552989-11	1989	Finally, the alcohol enhanced the quenching of the intrinsic fluorescence of EF-G caused by either acrylamide or KI.	Acrylamide	99-109	G elongation factor mitochondrial 1	Homo sapiens	77-81
2598317-4	1989	Perturbation of the microenvironment around NPM-labeled SH groups associated with desialylation by the enzyme treatment was also determined by measuring the increase of fluorescence anisotropy and decrease of quenching efficiency with acrylamide or CH3COOTl of the complex.	Acrylamide	235-245	nucleophosmin 1	Homo sapiens	44-47
2775753-2	1989	Tryptophan 99 fluoresces with a maximum around 348 nm and is easily quenched by fluorescence quenchers such as acrylamide, indicating that the chromophore is in a polar environment and well exposed to the solvent, a location which has been reported previously for tyrosine 99 in mammalian calmodulin [Kilhoffer, M. C., Demaille, J. G., & Gerard, D. (1981) Biochemistry 20, 4407-4414].	Acrylamide	111-121	calmodulin 1	Homo sapiens	289-299
18588114-0	1989	Biotransformation of acrylonitrile to acrylamide using immobilized whole cells of Brevibacterium CH1 in a recycle fed-batch reactor.	Acrylamide	38-48	SUN domain containing ossification factor	Homo sapiens	97-100
18588114-1	1989	Acrylamide was produced from acrylonitrile using immobilized Brevibacterium CH1 cells that were isolated from soil and found to possess nitrile hydratase activity.	Acrylamide	0-10	SUN domain containing ossification factor	Homo sapiens	76-79
2721786-2	1989	Acrylamide was extracted into ethyl acetate after derivatization by bromination to 2,3-dibromopropionamide (2,3-DBPA).	Acrylamide	0-10	Y-box binding protein 3	Homo sapiens	112-116
2464860-0	1989	Cytoskeletal effects of acrylamide and 2,5-hexanedione: selective aggregation of vimentin filaments.	Acrylamide	24-34	vimentin	Homo sapiens	81-89
2464860-6	1989	Both acrylamide and 2,5-HD caused aggregation of vimentin filaments in a concentration-dependent fashion; these effects occurred at a lower concentration than alterations in other cytoskeletal filaments.	Acrylamide	5-15	vimentin	Homo sapiens	49-57
2464860-11	1989	These results suggest that both acrylamide and 2,5-HD cause a primary collapse of vimentin intermediate filaments in cultured cells.	Acrylamide	32-42	vimentin	Homo sapiens	82-90
2694444-0	1989	Fibronectin network recovery in confluent PtK2 cells after acrylamide treatment.	Acrylamide	59-69	fibronectin 1	Homo sapiens	0-11
2694444-0	1989	Fibronectin network recovery in confluent PtK2 cells after acrylamide treatment.	Acrylamide	59-69	protein tyrosine kinase 2	Homo sapiens	42-46
2694444-1	1989	Confluent PtK2 cells 4 hr treated with 5 mM acrylamide were FN-detected by indirect immunofluorescence.	Acrylamide	44-54	protein tyrosine kinase 2	Homo sapiens	10-14
3053716-6	1988	Comparative lifetime and acrylamide quenching studies suggest that there are differences in the conformations of apo-CRBP and apo-CRBP II.	Acrylamide	25-35	retinol binding protein 2	Rattus norvegicus	130-137
3178832-4	1988	The band containing this insert (separated by acrylamide gel electrophoresis) was lost when the DNA was incubated with purified PKC preparations.	Acrylamide	46-56	proline rich transmembrane protein 2	Homo sapiens	128-131
2901342-3	1988	Affinity labeling of these membrane receptors by covalent attachment to [125I]TGF beta with bis-(sulfosuccinimidyl)suberate and subsequent electrophoretic analysis of the labeled complexes revealed the specific binding of [125I]TGF beta to a macromolecule that predominantly migrates as a 260,000 mol wt band in 7.5% acrylamide gels.	Acrylamide	317-327	transforming growth factor, beta 1	Rattus norvegicus	228-236
3219335-6	1988	The binding of the peptide to CaM 78-148 also caused a significant loss of the accessibility of the peptide tryptophan to the fluorescence quencher acrylamide.	Acrylamide	148-158	calmodulin 1	Homo sapiens	30-33
3383851-3	1988	125I-alpha-thrombin was detected in high-molecular-mass complexes (a) at the top of a 3% acrylamide stacking gel and (b) with a Mr approximately equal to 400,000.	Acrylamide	89-99	coagulation factor II, thrombin	Homo sapiens	11-19
3140894-7	1988	KI-depolymerized acto-S-1 complexes cross-linked by EDC, GA, or EEDQ were digested by thrombin which cuts only actin, releasing S-1 heavy chain-actin peptide cross-linked complexes migrating on acrylamide gels with Mr 100K (EDC), 110K and 105K (GA), and 102K (EEDQ); these were fluorescent only when fluorescent S-1 was used.	Acrylamide	194-204	coagulation factor II, thrombin	Homo sapiens	86-94
3376145-5	1988	In contrast, both acrylamide and 2,5-hexanedione caused a perinuclear redistribution of vimentin filaments with sparing of microtubules.	Acrylamide	18-28	vimentin	Homo sapiens	88-96
3372590-3	1988	To study this in greater detail, MAP1.2 in PC12 cell lysates was resolved by SDS-PAGE in gels containing 3.25% acrylamide/4 M urea and identified by comigration with material immunoprecipitated from the lysates by MAP1 antibodies.	Acrylamide	111-121	Blood pressure QTL 196	Rattus norvegicus	33-37
3376145-7	1988	Selective action of both acrylamide and 2,5-hexanedione on vimentin filaments and the similarity of effects suggest that a common mechanism of damage may occur whereby these compounds act directly on both vimentin and neurofilaments.	Acrylamide	25-35	vimentin	Homo sapiens	59-67
3376145-7	1988	Selective action of both acrylamide and 2,5-hexanedione on vimentin filaments and the similarity of effects suggest that a common mechanism of damage may occur whereby these compounds act directly on both vimentin and neurofilaments.	Acrylamide	25-35	vimentin	Homo sapiens	205-213
3608982-3	1987	The major products made in bacteria as well as the products of in vitro translation of zeste RNA migrate anomalously upon SDS--acrylamide gel electrophoresis.	Acrylamide	127-137	zeste	Drosophila melanogaster	87-92
3259146-1	1988	Quenching of the tryptophanyl fluorescence of cytochrome P-450C-21 by acrylamide and its relationship to substrate binding are investigated by using steady-state and time-resolved data.	Acrylamide	70-80	steroid 21-hydroxylase	Bos taurus	46-66
3280332-3	1988	The purified proteinase showed a major protein band having molecular weight of 17,000 on sodium dodecyl sulfate-polyacrylamide-gel electrophoresis (SDS-PAGE) and an active band on a non-denaturing acrylamide gel.	Acrylamide	116-126	endogenous retrovirus group K member 25	Homo sapiens	13-23
3301839-2	1987	Tryptophans 44,200, and 312 of recombinant human renin were found to be totally inaccessible to the ionic quenchers cesium and iodide and only partially accessible to the penetrating quencher acrylamide.	Acrylamide	192-202	renin	Homo sapiens	49-54
3651415-9	1987	Solute quenching experiments with the neutral polar quencher acrylamide reveal that upon lowering the pH to 5.0 a marked increase in the exposure of the lone Trp-88 residue in each beta-polypeptide chain of CT B occurs.	Acrylamide	61-71	phosphate cytidylyltransferase 1B, choline	Homo sapiens	207-211
2463103-0	1988	Acrylamide treatment of PtK1 cells causes dephosphorylation of keratin polypeptides.	Acrylamide	0-10	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	24-28
2829226-5	1988	The CSF released from marrow cells by low pH revealed two peaks of radioactivity on SDS-acrylamide gel.	Acrylamide	88-98	colony stimulating factor 2	Homo sapiens	4-7
3694262-2	1987	Similarities in molecular weight (43-47 kDa), pI (4.3-4.5), and aberrant behavior in acrylamide gels suggested that GAP-43 might be related or identical to protein F1, a protein kinase C substrate that has been shown to undergo a change in phosphorylation state during long-term potentiation in the hippocampus.	Acrylamide	85-95	growth associated protein 43	Homo sapiens	116-122
2433402-6	1987	Two-dimensional separations of the labelled proteins revealed increased labelling of growth-associated protein 43 in acrylamide-treated animals, but again this was less pronounced than in regenerating nerves.	Acrylamide	117-127	growth associated protein 43	Rattus norvegicus	85-113
3565751-7	1987	Bovine serum albumin, having an acidic isoelectric point, and the basic protein cytochrome c were treated with different acrylamide concentrations at alkaline pH yielding modified protein molecules with altered electrophoretic mobilities in different polyacrylamide gel electrophoresis systems.	Acrylamide	121-131	cytochrome c, somatic	Homo sapiens	80-92
3103704-1	1986	We have studied the viscosity dependence of the acrylamide quenching of the fluorescence on the internal tryptophan residues in cod parvalbumin and ribonuclease T1, as well as the model systems.	Acrylamide	48-58	parvalbumin	Homo sapiens	132-143
3301467-5	1987	Characterization of the expressed proteins by acrylamide gel electrophoresis followed by immunological detection indicated that the proteins were produced as hybrids linked to the bacterial beta-galactosidase.	Acrylamide	46-56	galactosidase, beta 1	Rattus norvegicus	190-208
3577066-1	1987	Content of cytochrome P-450 was decreased in rat liver microsomes, pretreated with phenobarbital, after incubation with acrylamide, methyl methacrylate and butyl methacrylate in presence of NADPH in vitro.	Acrylamide	120-130	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	11-27
3723019-0	1986	Separation of apolipoprotein B species by agarose-acrylamide gel electrophoresis.	Acrylamide	50-60	apolipoprotein B	Homo sapiens	14-30
3521726-2	1986	We find that the pentameric form of egg nucleoplasmin exhibits an apparent molecular mass approximately 15 000 daltons larger than its oocyte counterpart upon sodium dodecyl sulfate (SDS)-acrylamide gel electrophoresis.	Acrylamide	188-198	nucleophosmin/nucleoplasmin 2 S homeolog	Xenopus laevis	40-53
3008946-4	1986	In vitro, GST activity was also inhibited as a function of acrylamide concentration.	Acrylamide	59-69	hematopoietic prostaglandin D synthase	Rattus norvegicus	10-13
3008946-6	1986	Repeated administration of either acrylamide or bis-acrylamide in rats (50 mg/kg X 10 days) decreased GSH content in the brain but GST activity was inhibited only by acrylamide and not by bis-acrylamide.	Acrylamide	34-44	hematopoietic prostaglandin D synthase	Rattus norvegicus	131-134
3008946-6	1986	Repeated administration of either acrylamide or bis-acrylamide in rats (50 mg/kg X 10 days) decreased GSH content in the brain but GST activity was inhibited only by acrylamide and not by bis-acrylamide.	Acrylamide	52-62	hematopoietic prostaglandin D synthase	Rattus norvegicus	131-134
3099838-2	1986	In aqueous solution, the bimolecular quenching constants (k*) for lipid-free apo A-I fluorescence quenching by oxygen and acrylamide are 2.4 X 10(9) and 0.38 X 10(9) M-1 s-1, respectively.	Acrylamide	122-132	apolipoprotein A1	Homo sapiens	77-84
2430627-4	1986	Dynamic quenching of the conjugated pyrene moiety by acrylamide, and iodide ions is markedly reduced upon reaction of the protease with alpha 2-macroglobulin, indicating a reduced accessibility of the protease active center in the complex.	Acrylamide	53-63	alpha-2-macroglobulin	Homo sapiens	136-157
3732207-0	1986	Interaction of acrylamide with bovine serum albumin.	Acrylamide	15-25	albumin	Homo sapiens	38-51
3732207-1	1986	The binding of acrylamide (ACR) with purified bovine serum albumin (BSA) was studied.	Acrylamide	15-25	albumin	Homo sapiens	53-66
3732207-1	1986	The binding of acrylamide (ACR) with purified bovine serum albumin (BSA) was studied.	Acrylamide	27-30	albumin	Homo sapiens	53-66
3723019-4	1986	We have developed an agarose-acrylamide gel electrophoretic method to separate the two major apoB forms.	Acrylamide	29-39	apolipoprotein B	Homo sapiens	93-97
4047509-0	1985	Inhibition of glyceraldehyde-3-phosphate dehydrogenase in tissues of the rat by acrylamide and related compounds.	Acrylamide	80-90	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	14-54
3008946-0	1986	Effect of single and repeated doses of acrylamide and bis-acrylamide on glutathione-S-transferase and dopamine receptors in rat brain.	Acrylamide	39-49	hematopoietic prostaglandin D synthase	Rattus norvegicus	72-97
3964650-4	1986	The quenching of LpL fluorescence by acrylamide and iodide ion was decreased only slightly by addition of C14-ether-PC vesicles.	Acrylamide	37-47	lipoprotein lipase	Homo sapiens	17-20
3271050-8	1986	Stern-Volmer plots were linear and yield for the coat protein dimer with acrylamide a quenching constant of 4.5* 10(8) M-1 sec-1.	Acrylamide	73-83	secretory blood group 1, pseudogene	Homo sapiens	123-128
3006758-1	1986	The receptor for vasoactive intestinal peptide (VIP) was identified in rat liver plasma membranes after covalent cross-linking to 125I-VIP by three different agents [disuccinimido dithiobis(propionate), disuccinimido suberate, and succinimido 4-azidobenzoate] and examined by sodium dodecyl sulfate-acrylamide electrophoresis.	Acrylamide	299-309	vasoactive intestinal peptide	Rattus norvegicus	17-46
3006758-1	1986	The receptor for vasoactive intestinal peptide (VIP) was identified in rat liver plasma membranes after covalent cross-linking to 125I-VIP by three different agents [disuccinimido dithiobis(propionate), disuccinimido suberate, and succinimido 4-azidobenzoate] and examined by sodium dodecyl sulfate-acrylamide electrophoresis.	Acrylamide	299-309	vasoactive intestinal peptide	Rattus norvegicus	48-51
3080204-1	1986	The activity of protein kinase has been assayed in neurofilament preparations from spinal cords of rats treated with acrylamide.	Acrylamide	117-127	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	16-30
3698106-0	1986	Alteration of the distribution of intermediate filaments in PtK1 cells by acrylamide.	Acrylamide	74-84	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	60-64
3956794-2	1986	It was shown that butylated hydroxyanisole, acrylonitrile, vinylpyrrolidone and acrylamide have the capacity to increase rat liver ODC activity, while butylated hydroxytoluene, acrylic acid and sodium cyclamate did not affect ODC activity.	Acrylamide	80-90	ornithine decarboxylase 1	Rattus norvegicus	131-134
3956794-2	1986	It was shown that butylated hydroxyanisole, acrylonitrile, vinylpyrrolidone and acrylamide have the capacity to increase rat liver ODC activity, while butylated hydroxytoluene, acrylic acid and sodium cyclamate did not affect ODC activity.	Acrylamide	80-90	ornithine decarboxylase 1	Rattus norvegicus	226-229
4062287-3	1985	Homogeneity of the purified mucin was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis at varying concentrations of acrylamide, lectin affinity chromatography, and Western blot analysis.	Acrylamide	79-89	solute carrier family 13 member 2	Rattus norvegicus	28-33
4047509-2	1985	The present study examines the characteristics of the in vitro inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and compares the in vivo effects of acrylamide on GAPDH activity to other analogs.	Acrylamide	162-172	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	176-181
4047509-3	1985	Inhibition of GAPDH produced by acrylamide was characteristic of an irreversible or slowly reversible mechanism.	Acrylamide	32-42	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	14-19
4047509-4	1985	In vivo, GAPDH activity was determined in sciatic nerve, brain, skeletal muscle and liver after cumulative doses of 250, 350 or 500 mg/kg of acrylamide.	Acrylamide	141-151	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	9-14
4047509-7	1985	Specific activity of GAPDH was decreased in medulla pons, cerebellum and the rest of the brain after a 350 mg/kg cumulative dose of acrylamide, although protein concentrations were not different from those in controls.	Acrylamide	132-142	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	21-26
3004383-1	1985	The effect of acrylamide and six analogues on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and enolase in sciatic nerve was examined in rats after their prolonged administration in drinking water.	Acrylamide	14-24	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	46-86
3004383-1	1985	The effect of acrylamide and six analogues on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and enolase in sciatic nerve was examined in rats after their prolonged administration in drinking water.	Acrylamide	14-24	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	88-93
3718526-3	1986	Upon cross-linking with dimethylpimelimidate and acrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), the enzyme exhibited molecular weight forms from monomeric to heptameric BDH as well as higher molecular weight aggregates that did not much penetrate the gels.	Acrylamide	49-59	3-hydroxybutyrate dehydrogenase 1	Bos taurus	202-205
4027645-4	1985	GAPDH activity in Schwann cells in denervated P and T nerves of acrylamide-treated cats was markedly reduced (56% and 61% of untreated denervated nerves, respectively).	Acrylamide	64-74	glyceraldehyde-3-phosphate dehydrogenase	Felis catus	0-5
4027645-6	1985	Acrylamide (0.5 and 20 mM) inhibited GAPDH activity in denervated nerve homogenates by 67% and 29%, respectively.	Acrylamide	0-10	glyceraldehyde-3-phosphate dehydrogenase	Felis catus	37-42
4027645-7	1985	This study demonstrates that acrylamide inhibits GAPDH in Schwann cells.	Acrylamide	29-39	glyceraldehyde-3-phosphate dehydrogenase	Felis catus	49-54
4027645-8	1985	The significance of GAPDH inhibition by acrylamide in denervated nerves and its relation to distal axonopathy has been discussed.	Acrylamide	40-50	glyceraldehyde-3-phosphate dehydrogenase	Felis catus	20-25
4052574-3	1985	Solute quenching studies of the tryptophan fluorescence of parvalbumin reveal dynamic quenching rate constants, kq, of 1.1 X 10(8) and 2.3 X 10(9) M-1 s-1 (at 25 degrees C) with acrylamide and oxygen, respectively, as quenchers.	Acrylamide	178-188	parvalbumin	Homo sapiens	59-70
2996058-1	1985	Two isoenzymes of oxytocinase (EC 3.4.11.3) activity were fractionated from human amniotic fluid samples between the 14th and 22nd weeks of gestation by Ultrogel acrylamide-agarose gel filtration and partially characterized.	Acrylamide	162-172	leucyl and cystinyl aminopeptidase	Homo sapiens	18-29
3158653-1	1985	The tryptophan intrinsic fluorescence of the (Ca2+ + Mg2+)-ATPase from sarcoplasmic reticulum was quenched by acrylamide at different temperatures.	Acrylamide	110-120	dynein axonemal heavy chain 8	Homo sapiens	59-65
4033869-3	1985	Proteins from the acrylamide gels were transferred to nitrocellulose sheets which were treated with anti-bovine GFAP serum and GFAP was identified by the immunoblot technique.	Acrylamide	18-28	glial fibrillary acidic protein	Rattus norvegicus	112-116
4033869-3	1985	Proteins from the acrylamide gels were transferred to nitrocellulose sheets which were treated with anti-bovine GFAP serum and GFAP was identified by the immunoblot technique.	Acrylamide	18-28	glial fibrillary acidic protein	Rattus norvegicus	127-131
2411559-0	1985	Alteration of intermediate filament distribution in PtK1 cells by acrylamide.	Acrylamide	66-76	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	52-56
2411559-1	1985	PtK1 cells were treated with low concentrations of acrylamide resulting in disruption of intermediate filament networks.	Acrylamide	51-61	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	0-4
2411559-2	1985	An optimum treatment, 5 mM acrylamide in culture medium for 4 h, resulted in formation of a juxtanuclear aggregate containing both keratin and vimentin intermediate filaments.	Acrylamide	27-37	vimentin	Homo sapiens	143-151
2411559-4	1985	Cells recovered when acrylamide was washed out of the cultures, and normal keratin and vimentin networks reappeared.	Acrylamide	21-31	vimentin	Homo sapiens	87-95
3985992-4	1985	Our results suggest that an intermediate formed by the cytochrome P-450 system may be responsible for acrylamide neurotoxicity.	Acrylamide	102-112	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	55-71
3986181-1	1985	The accessibility of protein tryptophan fluorescence to the quenching agent acrylamide has been studied in adenosine deaminase and in binary complexes of the enzyme with ground-state or transition-state analogues.	Acrylamide	76-86	adenosine deaminase	Homo sapiens	107-126
3918018-2	1985	Cells transformed with a plasmid carrying either the STA1 or STA3 gene secreted glucoamylases having the same enzymatic and immunological properties and the same electrophoretic mobilities in acrylamide gel electrophoresis as those of authentic glucoamylases.	Acrylamide	192-202	Wsc2p	Saccharomyces cerevisiae S288C	61-65
2981375-2	1985	The in vivo activities of two glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase and nerve-specific enolase, were resistant to acrylamide.	Acrylamide	137-147	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	50-90
2990610-2	1985	The human active granulocyte-macrophage colony-stimulating factor (GM-CSF) for day 7 CFU-GM and the GM-DF for WEHI-3B(D+) and for HL-60 are not separable by acrylamide agarose column chromatography, eluting at an apparent molecular weight between 20,000 and 35,000 daltons, or by isoelectric focusing (isoelectric point, pH 5.4).	Acrylamide	157-167	colony stimulating factor 2	Homo sapiens	67-73
6523524-5	1984	Glutathione-S-transferase (GST) activity using acrylamide and 1-chloro 2,4-dinitrobenzene (CDNB) as substrates followed the order: liver greater than kidney greater than brain greater than erythrocytes.	Acrylamide	47-57	hematopoietic prostaglandin D synthase	Rattus norvegicus	0-25
6523524-5	1984	Glutathione-S-transferase (GST) activity using acrylamide and 1-chloro 2,4-dinitrobenzene (CDNB) as substrates followed the order: liver greater than kidney greater than brain greater than erythrocytes.	Acrylamide	47-57	hematopoietic prostaglandin D synthase	Rattus norvegicus	27-30
6140964-4	1983	Acrylamide-gel electrophoresis patterns of soluble tyrosinase from the Ab melanoma cells cultured in vitro consisted of two bands, similarly as soluble tyrosinase from the Ma melanotic melanoma cells freshly isolated from solid tumors.	Acrylamide	0-10	tyrosinase	Homo sapiens	51-61
6491156-1	1984	The quenching of intrinsic fluorescence of human serum albumin and pigeon liver malic enzyme by acrylamide was studied after the proteins were denatured to different stages.	Acrylamide	96-106	albumin	Homo sapiens	55-62
6442037-1	1984	A complex, exhibiting the maximal absorption at 385-388 nm and minimal at 414-420 nm, was formed after interaction between cytochrome P-450 and methylmethacrylate and acrylamide at 5 mM concentration.	Acrylamide	167-177	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	123-139
6474510-5	1984	These results suggest that cathepsin-D and beta-glucuronidase may be involved in the acrylamide-induced degeneration of nervous tissues and can serve as useful markers for the detection of chemical-induced neuropathies.	Acrylamide	85-95	cathepsin D	Rattus norvegicus	27-38
6474510-5	1984	These results suggest that cathepsin-D and beta-glucuronidase may be involved in the acrylamide-induced degeneration of nervous tissues and can serve as useful markers for the detection of chemical-induced neuropathies.	Acrylamide	85-95	glucuronidase, beta	Rattus norvegicus	43-61
6238021-4	1984	Fluorescence emission and acrylamide quenching studies revealed that the hydrophobicity of environment around the fluorophore and the degree of its burial in the protein vary with the base structure of NDP.	Acrylamide	26-36	norrin cystine knot growth factor NDP	Homo sapiens	202-205
6421997-6	1984	Neurotoxic chemicals (ammonia, methionine sulfoximine, acrylamide, carbon tetrachloride, and anisomycin) also increased brain ODC activity, whereas other chemicals (mannitol and valine) did not.	Acrylamide	55-65	ornithine decarboxylase 1	Rattus norvegicus	126-129
6470884-5	1984	The degree of crosslinking in soluble collagen was assessed by acrylamide gel electrophoresis and shown to be decreased in infected tissues.	Acrylamide	63-73	collagen, putative	Brugia malayi	38-46
6704549-0	1984	Effect of acrylamide on glutathione-S-transferase activity in different regions of rat brain.	Acrylamide	10-20	hematopoietic prostaglandin D synthase	Rattus norvegicus	24-49
6418745-3	1983	The lysosomal enzymes beta-glucuronidase and beta-galactosidase were isolated from each fraction by immunoprecipitation and electrophoresis on sodium dodecyl sulfate-acrylamide gels.	Acrylamide	166-176	glucuronidase, beta	Mus musculus	22-40
6418745-3	1983	The lysosomal enzymes beta-glucuronidase and beta-galactosidase were isolated from each fraction by immunoprecipitation and electrophoresis on sodium dodecyl sulfate-acrylamide gels.	Acrylamide	166-176	galactosidase, beta 1	Mus musculus	45-63
6227626-6	1983	Calmodulin was found to bind to seven specific granule membrane proteins after diffusion of 125I-labeled calmodulin into an acrylamide gel of membrane proteins separated by electrophoresis in the presence of sodium dodecyl sulfate.	Acrylamide	124-134	calmodulin	Bos taurus	0-10
6383574-2	1984	This report provides evidence that the 40 A insulin receptor migrates on dodecyl sulfate - acrylamide gel electrophoresis as a 90 000 dalton protein and that this protein is a single polypeptide chain.	Acrylamide	91-101	insulin receptor	Rattus norvegicus	44-60
6744626-0	1984	Determination of placental alkaline phosphatase phenotypes by starch-gel and acrylamide gel electrophoresis.	Acrylamide	77-87	alkaline phosphatase, placental	Homo sapiens	27-47
6744626-3	1984	All the placental ALP phenotypes detected had the same molecular mass by gradient acrylamide electrophoresis.	Acrylamide	82-92	alkaline phosphatase, placental	Homo sapiens	18-21
6328538-1	1984	Ultrogel acrylamide-agarose chromatography was employed for fractionation of oxytocinase isoenzymes from serum of pregnant women and from human placenta.	Acrylamide	9-19	leucyl and cystinyl aminopeptidase	Homo sapiens	77-88
6232867-2	1984	By examining the affects of urea concentration and acrylamide concentration upon the electrophoretic mobilities of the polypeptides comprising the nF1 enzyme, we have obtained conditions under which all five subunits are simultaneously resolved when the discontinuous buffer system of Laemmli is used (U. K. Laemmli (1970) Nature (London) 277, 680-685).	Acrylamide	51-61	neurofibromin 1	Homo sapiens	147-150
6083845-4	1984	After comparing their acrylamide electrophoresis and the action of several inhibitors upon the PAP and the alkaline phosphatase of various organ extracts, it is suggested that the two isoenzymes of PAP (indicated by heat inhibition) probably arise from bone and liver.	Acrylamide	22-32	phospholipid phosphatase 1	Mus musculus	198-201
6193841-4	1983	In contrast, acrylamide treatment causes major increases of retinal Met-enkephalin and neurotensin concentrations.	Acrylamide	13-23	neurotensin	Gallus gallus	87-98
6190267-0	1983	Altered retrograde axonal transport of nerve growth factor after single and repeated doses of acrylamide in the rat.	Acrylamide	94-104	nerve growth factor	Rattus norvegicus	39-58
20488078-4	1984	Analysis of purified choline acetyltransferase on polyacrylamide gel electrophoresis in sodium lauryl sulfate (15% acrylamide) revealed the presence of an additional polypeptide at 13 K Daltons.	Acrylamide	54-64	Choline acetyltransferase	Drosophila melanogaster	21-46
6883577-3	1983	In liver both acrylamide and styrene caused an increase in lipid peroxidation and decrease in glutathione contents and activity of glutathione-S-transferase in a dose dependent manner, while in brain only acrylamide produced a decrease in glutathione content.	Acrylamide	14-24	hematopoietic prostaglandin D synthase	Rattus norvegicus	131-156
6883577-3	1983	In liver both acrylamide and styrene caused an increase in lipid peroxidation and decrease in glutathione contents and activity of glutathione-S-transferase in a dose dependent manner, while in brain only acrylamide produced a decrease in glutathione content.	Acrylamide	205-215	hematopoietic prostaglandin D synthase	Rattus norvegicus	131-156
6883577-9	1983	The inhibition of glutathione-S-transferase activity by acrylamide and styrene suggests that detoxication of these neurotoxic compounds could be suppressed following acute exposure.	Acrylamide	56-66	hematopoietic prostaglandin D synthase	Rattus norvegicus	18-43
6190267-1	1983	The retrograde axoplasmic transport of iodinated nerve growth factor (125I-NGF) was markedly altered by systemic acrylamide treatment.	Acrylamide	113-123	nerve growth factor	Rattus norvegicus	49-68
6824774-1	1983	The effects of the antituberculous drugs, isoniazide, phthivazide, streptomycin and PAS, on the isoform content of rat liver microsomal cytochrome P-450 was studied by electrophoresis in acrylamide concentration gradient (5-15%) in the presence of sodium dodecyl sulphate.	Acrylamide	187-197	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	136-152
6224508-3	1983	When acrylamide was used as the quencher, the apparent Stern-Volmer quenching constant Ksv" for Tm was measured to be 5.78 M-1 and the quenching rate constant kq to be 3.20 X 10(8) M-1 s-1.	Acrylamide	5-15	tropomyosin alpha-1 chain	Oryctolagus cuniculus	96-98
6188440-6	1983	Changes in neuropeptide levels were only detected in the hypothalamus where a single acrylamide treatment caused elevated levels of beta-endorphin and substance P, and in frontal cortex where met-enkephalin levels were higher after repeated acrylamide injection.	Acrylamide	85-95	pyroglutamylated RFamide peptide	Rattus norvegicus	11-23
6188440-6	1983	Changes in neuropeptide levels were only detected in the hypothalamus where a single acrylamide treatment caused elevated levels of beta-endorphin and substance P, and in frontal cortex where met-enkephalin levels were higher after repeated acrylamide injection.	Acrylamide	241-251	pyroglutamylated RFamide peptide	Rattus norvegicus	11-23
6684458-0	1983	Effect of oral CDP-choline on acrylamide-induced lesion.	Acrylamide	30-40	cut-like homeobox 1	Mus musculus	15-18
6684458-1	1983	Administration of low doses of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) (50 mg/kg) to mice and rats has proved to be effective in preventing acrylamide-induced neurological syndrome.	Acrylamide	165-175	cut-like homeobox 1	Mus musculus	61-64
18548549-1	1983	A stable immobilized preparation of fumarase (EC 4.2.1.2) was obtained by entrapment of rat liver mitochondria in acrylamide polymerized by using gamma irradiation (100 kR).	Acrylamide	114-124	fumarate hydratase	Rattus norvegicus	36-44
6205971-1	1983	Spleen cells from BALB/c mice, immunized with SDS-acrylamide gel purified human fibroblast interferon (HuIFN-beta) were fused with mouse myeloma cells.	Acrylamide	50-60	interferon beta 1	Homo sapiens	80-101
6223924-1	1983	In order to obtain information about the actin-induced conformational change around the subfragment-1/subfragment-2 link region of myosin, measurements of the fluorescence quenching by acrylamide were made on cardiac myosin and its heavy meromyosin, in which the reactive lysyl residue located in the link region was labeled with an extrinsic fluorophore, the N-methyl-2-anilino-6-naphthalenesulfonyl group.	Acrylamide	185-195	myosin heavy chain 14	Homo sapiens	131-137
6757252-3	1982	By direct assay and by unidimensional and two-dimensional acrylamide electrophoretic separations the following T4-coded enzymes were shown to be associated with the complex: ribonucleoside diphosphate reductase, dCMP deaminase, dCTP/dUTPase, dCMP hydroxymethylase, dTMP synthetase, and DNA polymerase.	Acrylamide	58-68	cut up	Drosophila melanogaster	228-240
6819859-5	1982	Homogeneous LDH preparations exhibit one band on neutral acrylamide gels when the substrate is either DL-lactic acid or L-(+)-lactate.	Acrylamide	57-67	Lactate dehydrogenase	Drosophila melanogaster	12-15
7153455-7	1982	Ion exchange of acrylamide in a mixed resin, and recrystallization of bisacrylamide, were found necessary to avoid absorption from very dilute protein solutions as CSF.	Acrylamide	16-26	colony stimulating factor 2	Homo sapiens	164-167
6979358-6	1982	Following iodination, each purified pool of CSF revealed a major 63,000-dalton peak of radioactivity that comigrated with CSF activity in SDS-acrylamide gels.	Acrylamide	142-152	colony stimulating factor 2	Homo sapiens	44-47
6811833-2	1982	ApoA-I and apoE were demonstrated to be specific products by immunoprecipitation and fractionation on sodium dodecyl sulfate acrylamide gels.	Acrylamide	125-135	apolipoprotein A1	Rattus norvegicus	0-6
6811833-2	1982	ApoA-I and apoE were demonstrated to be specific products by immunoprecipitation and fractionation on sodium dodecyl sulfate acrylamide gels.	Acrylamide	125-135	apolipoprotein E	Rattus norvegicus	11-15
7135341-3	1982	Our studies showed that tryptophan residues of core fragments D and E are much more exposed to quenching effects of acrylamide and ions than intact fibrinogen, which may be caused by conformational changes occurring over the domains during plasmin digestion of fibrinogen molecule.	Acrylamide	116-126	fibrinogen beta chain	Homo sapiens	261-271
6979358-6	1982	Following iodination, each purified pool of CSF revealed a major 63,000-dalton peak of radioactivity that comigrated with CSF activity in SDS-acrylamide gels.	Acrylamide	142-152	colony stimulating factor 2	Homo sapiens	122-125
6890183-4	1982	Prolactin levels were significantly lower in acrylamide-exposed nonhandled animals.	Acrylamide	45-55	prolactin	Rattus norvegicus	0-9
6178969-0	1982	Acrylamide neuropathy and changes in the axonal transport and muscular content of the molecular forms of acetylcholinesterase.	Acrylamide	0-10	acetylcholinesterase (Cartwright blood group)	Gallus gallus	105-125
6178969-2	1982	In the sciatic nerve of acrylamide-poisoned chickens, the anterograde axonal transport of A12 AChE was reduced by 60%, and that of G4 by 21%, compared to control values whereas the slow axoplasmic transport of G1 and G2 was unaffected.	Acrylamide	24-34	acetylcholinesterase (Cartwright blood group)	Gallus gallus	94-98
6178969-4	1982	In acrylamide poisoning, the AChE molecular forms were considered as very sensitive markers of both axonal transport phases and of the innervation state.	Acrylamide	3-13	acetylcholinesterase (Cartwright blood group)	Gallus gallus	29-33
7080078-4	1982	The magnitude of these changes was related to the concentration of CS2 and the alterations were similar to those observed in the sciatic nerve of rats intoxicated with acrylamide.	Acrylamide	168-178	calsyntenin 2	Rattus norvegicus	67-70
7043462-4	1982	Second, NaDodSO4/acrylamide gel electrophoresis revealed that crotalase cleaves the plasma kallikrein-susceptible bonds in human high molecular weight kininogen, producing an intermediate with procoagulant activity.	Acrylamide	17-27	kallikrein related peptidase 4	Homo sapiens	91-101
6795195-3	1981	The purified mucin gave a single band upon electrophoresis in either 5% acrylamide or 1% agarose gels.	Acrylamide	72-82	LOC100508689	Homo sapiens	13-18
6212531-1	1982	Eleven Southern African populations (representing European, Asian and Negroid populations) have been typed for the first locus phosphoglucomutase (PGM1) using isoelectric focusing (pH range 5.0-8.0) in acrylamide gels.	Acrylamide	202-212	phosphoglucomutase 1	Homo sapiens	147-151
7309799-3	1981	This heat-shock polypeptide was identified as histone H2b by two criteria: (a) it comigrated with authentic histone H2b in Triton-urea-acetic acid acrylamide gel electrophoresis after solubilization from nuclei with acid; and (b) partial proteolysis peptide maps of the basic heat-shock protein and histone H2b were identical.	Acrylamide	147-157	histone H2B	Drosophila melanogaster	46-57
7309799-3	1981	This heat-shock polypeptide was identified as histone H2b by two criteria: (a) it comigrated with authentic histone H2b in Triton-urea-acetic acid acrylamide gel electrophoresis after solubilization from nuclei with acid; and (b) partial proteolysis peptide maps of the basic heat-shock protein and histone H2b were identical.	Acrylamide	147-157	histone H2B	Drosophila melanogaster	108-119
7309799-3	1981	This heat-shock polypeptide was identified as histone H2b by two criteria: (a) it comigrated with authentic histone H2b in Triton-urea-acetic acid acrylamide gel electrophoresis after solubilization from nuclei with acid; and (b) partial proteolysis peptide maps of the basic heat-shock protein and histone H2b were identical.	Acrylamide	147-157	histone H2B	Drosophila melanogaster	108-119
6268632-3	1981	Gel filtration on acrylamide agarose (AcA-22) at 23 degrees C in the absence of transferrin indicates the transferrin receptor has a Stokes radius of 4.6 nm.	Acrylamide	18-28	transferrin	Homo sapiens	106-117
7302987-0	1981	Reduction in cutaneous and hepatic glutathione contents, glutathione S-transferase and aryl hydrocarbon hydroxylase activities following topical application of acrylamide to mouse.	Acrylamide	160-170	hematopoietic prostaglandin D synthase	Mus musculus	57-82
6268632-3	1981	Gel filtration on acrylamide agarose (AcA-22) at 23 degrees C in the absence of transferrin indicates the transferrin receptor has a Stokes radius of 4.6 nm.	Acrylamide	18-28	small nucleolar RNA, H/ACA box 22	Homo sapiens	38-44
6456573-0	1981	The etiology of acrylamide neuropathy: enolase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase activities in peripheral nerve, spinal cord, brain, and skeletal muscle of acrylamide-intoxicated cats.	Acrylamide	189-199	glyceraldehyde-3-phosphate dehydrogenase	Felis catus	73-113
6269648-3	1981	On a 4.6% gel (acrylamide:bisacrylamide, 20:1), the material migrated as a diffuse band to a position between those of beta-galactosidase (Mr 130 000) and myosin (Mr 200 000).	Acrylamide	15-25	myosin heavy chain 14	Homo sapiens	155-161
6453524-2	1981	A method for isoelectric focusing of phosphoglucomutase (PGM1) using agarose was found to have significant advantages over published acrylamide technics.	Acrylamide	133-143	phosphoglucomutase 1	Homo sapiens	57-61
6269648-3	1981	On a 4.6% gel (acrylamide:bisacrylamide, 20:1), the material migrated as a diffuse band to a position between those of beta-galactosidase (Mr 130 000) and myosin (Mr 200 000).	Acrylamide	15-25	galactosidase beta 1	Homo sapiens	119-137
6784794-5	1981	When the acrylamide concentration in the gels was increased to 2.5%, bands with a faster mobility than IgM and fibronectin were now evident.	Acrylamide	9-19	fibronectin 1	Homo sapiens	111-122
7460835-1	1981	Disc electrophoretic analysis of prolactin (PRL) in the rat pituitary is usually performed using a 7.5% concentration of acrylamide gel.	Acrylamide	121-131	prolactin	Rattus norvegicus	33-42
7018580-7	1981	Neutral alpha-glucosidase AB migrates more rapidly to the anode than alpha-glucosidase C when agarose, Cellogel, acrylamide or starch are used as support media.	Acrylamide	113-123	glucosidase II alpha subunit	Homo sapiens	0-28
7018580-7	1981	Neutral alpha-glucosidase AB migrates more rapidly to the anode than alpha-glucosidase C when agarose, Cellogel, acrylamide or starch are used as support media.	Acrylamide	113-123	sucrase-isomaltase	Homo sapiens	8-25
7460835-1	1981	Disc electrophoretic analysis of prolactin (PRL) in the rat pituitary is usually performed using a 7.5% concentration of acrylamide gel.	Acrylamide	121-131	prolactin	Rattus norvegicus	44-47
7448422-1	1981	The behavior of rat transferrin has been investigated employing acrylamide gel electrophoresis and isoelectric focusing.	Acrylamide	64-74	transferrin	Rattus norvegicus	20-31
7018024-0	1981	In vitro inhibition of alcohol dehydrogenase by acrylamide: interaction with enzyme-SH groups.	Acrylamide	48-58	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
7018024-1	1981	Acrylamide, a reactive electrophile, caused a concentration-dependent inhibition of alcohol dehydrogenase (ADH) activity (purified) which was reversed by prior addition of glutathione.	Acrylamide	0-10	aldo-keto reductase family 1 member A1	Homo sapiens	84-105
7018024-1	1981	Acrylamide, a reactive electrophile, caused a concentration-dependent inhibition of alcohol dehydrogenase (ADH) activity (purified) which was reversed by prior addition of glutathione.	Acrylamide	0-10	aldo-keto reductase family 1 member A1	Homo sapiens	107-110
7018024-4	1981	The results demonstrate that acrylamide-induced inhibition of purified ADH activity is mediated through its specific interaction with -SH groups in the enzyme molecule.	Acrylamide	29-39	aldo-keto reductase family 1 member A1	Homo sapiens	71-74
6166195-3	1981	Subsequent studies of cholinesterase isozymes by acrylamide electrophoresis showed an abnormal acetylcholinesterase band in each of the three amniotic fluids.	Acrylamide	49-59	butyrylcholinesterase	Homo sapiens	22-36
6795605-7	1981	SDS-gel electrophoresis of the enzyme in different concentrations of acrylamide indicated that the subunit molecular weight of histaminase was about 90,000.	Acrylamide	69-79	amine oxidase copper containing 1	Homo sapiens	127-138
6306643-3	1981	Gel filtration on acrylamide agarose (AcA-22) at 21 degrees C in the absence of transferrin indicates that the transferrin-binding protein has a Stokes" radius of 4.6 nm.	Acrylamide	18-28	small nucleolar RNA, H/ACA box 22	Homo sapiens	38-44
6306643-3	1981	Gel filtration on acrylamide agarose (AcA-22) at 21 degrees C in the absence of transferrin indicates that the transferrin-binding protein has a Stokes" radius of 4.6 nm.	Acrylamide	18-28	transferrin	Homo sapiens	111-122
7222094-0	1981	Acrylamide induced inhibition of hepatic glutathione-S-transferase activity in rats.	Acrylamide	0-10	hematopoietic prostaglandin D synthase	Rattus norvegicus	41-66
7222094-2	1981	with acrylamide (50 mg/kg/day) for 5 days showed a significant inhibition of hepatic glutathione-S-transferase (GST) activity; maximum inhibition occurred in 15-day-old rats in which early development of hind limb paralysis was noted.	Acrylamide	5-15	hematopoietic prostaglandin D synthase	Rattus norvegicus	85-110
7222094-2	1981	with acrylamide (50 mg/kg/day) for 5 days showed a significant inhibition of hepatic glutathione-S-transferase (GST) activity; maximum inhibition occurred in 15-day-old rats in which early development of hind limb paralysis was noted.	Acrylamide	5-15	hematopoietic prostaglandin D synthase	Rattus norvegicus	112-115
7222094-3	1981	Addition of acrylamide in vitro to the assay system also inhibited GST activity.	Acrylamide	12-22	hematopoietic prostaglandin D synthase	Rattus norvegicus	67-70
6448665-3	1980	The order of increasing sensitivity to 2,5-hexanedione was enolase -- GAPDH -- PFK and to acrylamide the order was PFK -- enolase -- GAPDH.	Acrylamide	90-100	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	133-138
7000190-0	1980	Effects of glucose and magnesium ion on the quenching of yeast hexokinase fluorescence by acrylamide.	Acrylamide	90-100	hexokinase	Saccharomyces cerevisiae S288C	63-73
7000190-2	1980	Acrylamide was used as a quenching titrant in the absence and in the presence of glucose and Mg2+ singly and together at pH 5.5 and 8.3 at 20 degrees C. The four tryptophan residues of the monomeric subunit of yeast hexokinase may be classified as two surface residues, one being highly accessible to dissolved I- and one with restricted accessibility to I-, one glucose-quenchable residue in the cleft, and one buried (Kramp, D.C. and Feldman, I.	Acrylamide	0-10	hexokinase	Saccharomyces cerevisiae S288C	216-226
7370804-0	1980	The etiology of acrylamide neuropathy: possible involvement of neuron specific enolase.	Acrylamide	16-26	enolase 2	Rattus norvegicus	63-86
6105878-8	1980	By means of histochemical activity staining in acrylamide gels it was shown that the purified ATPase preparation could be inhibited by Cd2+ and Zn2+ salts, p-chloromercuribenzoate and N-ethylmaleimide, known inhibitors of membrane endocytosis.	Acrylamide	47-57	dynein axonemal heavy chain 8	Homo sapiens	94-100
7448199-2	1980	Amastatin, a specific inhibitor of aminopeptidase A (L-alpha-aspartyl(L-alpha-glutamyl)-peptide hydrolase, EC 3.4.11.7), was linked to an agarose matrix and by this affinity chromatography aminopeptidase A of pig kidneys was purified as a single protein shown by acrylamide gel electrophoresis.	Acrylamide	263-273	glutamyl aminopeptidase	Sus scrofa	35-51
7370804-1	1980	The effect of monomeric acrylamide, a potent neurotoxic agent, on total and neuron specific enolase activity was studied in vitro and in vivo.	Acrylamide	24-34	enolase 2	Rattus norvegicus	76-99
7370804-4	1980	In rats chronically treated with acrylamide (550 mg/kg total) and exhibiting marked symptoms of neurotoxicity, neuron specific enolase activity was not detectable in sciatic nerves and was only 60% of control activity in brain.	Acrylamide	33-43	enolase 2	Rattus norvegicus	111-134
6153276-2	1980	Antithrombin III-heparin cofactor has been isolated from normal rat plasma, purified to homogeneity on acrylamide gel electrophoresis and used to prepare a monospecific antiserum in rabbits.	Acrylamide	103-113	serpin family C member 1	Rattus norvegicus	0-16
6244854-1	1980	Isozymes of adenylate kinase (ATP:AMP phosphotransferase, EC 2.7.4.3) were purified from skeletal muscle and liver of rats to essentially homogeneous states by acrylamide gel electrophoresis and sodium dodecyl sulfate gel electrophoresis.	Acrylamide	160-170	adenylate kinase 2	Rattus norvegicus	30-56
7358641-2	1980	D-Erythrulose reductase from chicken liver has been purified to homogeneity as judged by acrylamide gel electrophoresis and ultracentrifugation.	Acrylamide	89-99	dicarbonyl and L-xylulose reductase	Gallus gallus	0-23
305893-3	1978	A study of the physico-chemical properties of the LCEF revealed that it is a nondialyzable, heat-labile molecule which migrates in the haptoglobin (2--2) post-transferrin region in acrylamide electrophoresis.	Acrylamide	181-191	transferrin	Homo sapiens	159-170
112098-2	1979	Coomassie blue staining of stroma components separated by sodium dodecyl sulfate-acrylamide gel electrophoresis indicates that treatment of red cells with endo-beta-galactosidase converts Protein 3, the anion transporter of the erythrocyte, to a more compact staining band.	Acrylamide	81-91	galactosidase beta 1	Homo sapiens	160-178
436762-7	1979	Analytical acrylamide disc gel electrophoresis at pH 4.3 demonstrated that CM1 and CM2 had different electrophoretic mobilities.	Acrylamide	11-21	Cardiac mass QTL 1	Rattus norvegicus	75-78
758695-2	1979	The purity of the lipase and colipase preparations was established by acrylamide gel electrophoresis.	Acrylamide	70-80	colipase	Canis lupus familiaris	29-37
33344-1	1978	Two different molecular forms of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1) have been isolated from the brain and adrenal glands of the rat as indicated by certain of their physicochemical properties, such as: molecular weight estimated on the basis of gel chromatography of Sephadex G-100; pH optima; electrophoretic mobility on acrylamide gel; and steady-state kinetic parameters.	Acrylamide	343-353	phenylethanolamine-N-methyltransferase	Rattus norvegicus	33-71
33344-1	1978	Two different molecular forms of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1) have been isolated from the brain and adrenal glands of the rat as indicated by certain of their physicochemical properties, such as: molecular weight estimated on the basis of gel chromatography of Sephadex G-100; pH optima; electrophoretic mobility on acrylamide gel; and steady-state kinetic parameters.	Acrylamide	343-353	phenylethanolamine-N-methyltransferase	Rattus norvegicus	73-77
716947-0	1978	Qualitative alterations of cytochrome P-450 in mouse liver microsomes after administration of acrylamide and methylmethacrylate.	Acrylamide	94-104	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	27-43
716947-1	1978	Cytochrome P-450 in mouse liver microsomes was characterized by SDS-polyacrylamide gel electrophoresis after intraperitoneal injection of 80 mg phenobarbital, 4.5 and 45 mg acrylamide and 60 and 600 mg methylmethacrylate per kg body weight each day for four days.	Acrylamide	72-82	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
716947-3	1978	The amount of cytochrome P-450 with a molecular weight of 47,000 (MLvMcP-450(47) decreased in the phenobarbital group and in both acrylamide groups.	Acrylamide	130-140	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	14-30
295043-1	1979	An acrylamide gel electrophoretic procedure is described which allows the separation of human quinoid-dihydropteridine reductase (QDPR), EC 1.6.5.1) from the homologous enzyme expressed in established rodent cell lines.	Acrylamide	3-13	quinoid dihydropteridine reductase	Homo sapiens	94-128
295043-1	1979	An acrylamide gel electrophoretic procedure is described which allows the separation of human quinoid-dihydropteridine reductase (QDPR), EC 1.6.5.1) from the homologous enzyme expressed in established rodent cell lines.	Acrylamide	3-13	quinoid dihydropteridine reductase	Homo sapiens	130-134
366841-2	1978	The mode and degree of tryptophanyl orientation relative to muscle fiber axes within hydrophobic and hydrophylic sites of myosin macromolecule in the presence of a fluorescence quencher (acrylamide, NO-3) during rigor and relaxation of glycerinated muscle fibers were studied using the polarized ultraviolet fluorescent microscopy.	Acrylamide	187-197	myosin heavy chain 14	Homo sapiens	122-128
211778-6	1978	Disc electrophoresis with an acrylamide gel indicated that big ACTH is strongly basic while small ACTH is more acidic than pH 8.3.	Acrylamide	29-39	proopiomelanocortin	Homo sapiens	63-67
686071-1	1978	Ovarian tumor-associated antigen isolated from human tumor tissue was shown to have a different mobility from that of carcinoembryonic antigen (CEA) in both acrylamide gel electrophoresis and immunoelectrophoresis in agarose.	Acrylamide	157-167	CEA cell adhesion molecule 3	Homo sapiens	118-142
686071-1	1978	Ovarian tumor-associated antigen isolated from human tumor tissue was shown to have a different mobility from that of carcinoembryonic antigen (CEA) in both acrylamide gel electrophoresis and immunoelectrophoresis in agarose.	Acrylamide	157-167	CEA cell adhesion molecule 3	Homo sapiens	144-147
78970-0	1978	Studies on axoplasmic transport of individual proteins: 1--Acetylcholinesterase (AChE) in acrylamide neuropathy.	Acrylamide	90-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-79
78970-0	1978	Studies on axoplasmic transport of individual proteins: 1--Acetylcholinesterase (AChE) in acrylamide neuropathy.	Acrylamide	90-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
308033-1	1978	A group of 202 unrelated Italians were screened for alpha1-antitrypsin using agarose-acrylamide electrophoresis and isoelectric focusing.	Acrylamide	85-95	serpin family A member 1	Homo sapiens	52-70
197021-6	1977	This method was also used to isolate a form of enterotoxin that has a mobility, relative to bromophenol blue tracking dye, of 0.87 to 0.90 in 7% acrylamide gels.	Acrylamide	145-155	cpe	Clostridium perfringens	47-58
908740-3	1977	Acrylamide gel electrophoresis of crude G6PD preparations revealed three distinct bands of enzymatic activity.	Acrylamide	0-10	glucose-6-phosphate dehydrogenase	Homo sapiens	40-44
20997-0	1977	[Dependence of thrombin- and trypsin-catalyzed hydrolysis of N-alpha-arylsulfonyl-L-arginine methyl esters on the structure of acylamide part of substrates].	Acrylamide	127-136	coagulation factor II, thrombin	Homo sapiens	15-23
617802-2	1977	Lymphotactin has been isolated and purified by ethanol fractionation, ultrafiltration, isoelectric focusing, and preparative acrylamide gel electrophoresis.	Acrylamide	125-135	lymphotactin	Bos taurus	0-12
891540-6	1977	The "freezing" of the conformation of apohemoglobin upon binding to haptoglobin has been studied by fluorescence quenching experiments carried out in the presence of 8 M acrylamide.	Acrylamide	170-180	haptoglobin	Homo sapiens	68-79
192733-12	1977	Dodecyl sulfate-acrylamide gel electrophoresis of immunoprecipitated 3H-VLDL reveals three major apopepetides of 300,000, 11,000, and 8,000 daltons corresponding to those of purified chicken VLDL.	Acrylamide	16-26	very low density lipoprotein receptor	Gallus gallus	72-76
192733-12	1977	Dodecyl sulfate-acrylamide gel electrophoresis of immunoprecipitated 3H-VLDL reveals three major apopepetides of 300,000, 11,000, and 8,000 daltons corresponding to those of purified chicken VLDL.	Acrylamide	16-26	very low density lipoprotein receptor	Gallus gallus	191-195
839187-1	1977	Several isozymes of acetylcholinesterase are separated by 10% acrylamide gel electrophoresis of mouse blood, brain, heart, muscle and tongue tissues.	Acrylamide	62-72	acetylcholinesterase	Mus musculus	20-40
1069994-3	1976	The peptides produced by cyanogen bromide digestion of the collagen are identical to those from authentic type II collagen from cartilage in charge properties, as determined by carboxymethyl-cellulose chromatography, and size distribution, as determined by sodium dodecyl sulfate-acrylamide gel electrophoresis.	Acrylamide	280-290	collagen type II alpha 1 chain	Gallus gallus	106-122
1001880-1	1976	Acrylamide gel electrophoresis was performed on the enzyme xanthine dehydrogenase in sixty isochromosomal lines of Drosophila persimilis from three geographic populations.	Acrylamide	0-10	xanthine dehydrogenase	Drosophila persimilis	59-81
10292-4	1976	Analyses of subunits in the purified myosin were carried out on 3.5% acrylamide gel with 0.1% SDS.	Acrylamide	69-79	myosin X	Sus scrofa	37-43
184460-6	1976	PC1 is inactive with the initiation factor, but phosphorylates 40S subunits at a single major site that migrates as a 31,000-dalton band in sodium dodecyl sulfate-acrylamide gels; phosphorylation requires cyclic AMP.	Acrylamide	163-173	proprotein convertase subtilisin/kexin type 1	Bos taurus	0-3
986157-2	1976	This highly purified myosin mRNP-tcRNA is shown to have a molecular weight of 10 000 on formamide-acrylamide gels, and reacts stoichometrically (on a 1:1 mole ratio) with myosin mRNA.	Acrylamide	98-108	myosin, heavy chain 15	Gallus gallus	21-27
133717-5	1976	The ATPase has an apparent molecular weight of approximately 100 000 as determined by electrophoresis in acrylamide gels containing dodecyl sulphate.	Acrylamide	105-115	dynein axonemal heavy chain 8	Homo sapiens	4-10
177416-11	1976	In sodium dodecyl sulfate-acrylamide gel scans of the complex, the subunits of F1, OSCP, and three other major bands with apparent molecular weights of 32,000, 23,000, and about 11,000 were noted.	Acrylamide	26-36	ATP synthase peripheral stalk subunit OSCP	Bos taurus	83-87
175830-2	1976	When analyzed by dodecyl sulfate acrylamide electrophoresis this molecule forms two PAS-stainable bands (PAS-U and PAS-2) which are reversibly interconvertible.	Acrylamide	33-43	glycophorin A (MNS blood group)	Homo sapiens	115-120
24194428-2	1976	This MIF could be purified by precipitation with 70% ethanol, concentrated by ultrafiltration between 30,000 and 50,000 daltons, isoelectrically focused at pH 6.8-7.1, and electrophoresed on preparative acrylamide gels.	Acrylamide	203-213	macrophage migration inhibitory factor	Homo sapiens	5-8
28325-4	1978	Electrophoresis of the immunoprecipitates on sodium didecyl sulfate-acrylamide gels isolates the subunit of glutamine synthetase and permits the radioactivity in the glutamine synthetase band to be quantitated.	Acrylamide	68-78	glutamate-ammonia ligase	Rattus norvegicus	108-128
28325-4	1978	Electrophoresis of the immunoprecipitates on sodium didecyl sulfate-acrylamide gels isolates the subunit of glutamine synthetase and permits the radioactivity in the glutamine synthetase band to be quantitated.	Acrylamide	68-78	glutamate-ammonia ligase	Rattus norvegicus	166-186
24271248-2	1976	Incubation with calf brain cathepsin D did not result in a significant relese of acid-soluble peptides as measured by ninhydrin analysis but was accompanied by a large loss of myelin proteins as determined on SDS-acrylamide gels.	Acrylamide	213-223	cathepsin D	Bos taurus	27-38
1061124-2	1976	A product was synthesized which was immunologically related to growth hormone, but which migrated more slowly than growth hormone upon sodium dodecyl sulfate-acrylamide gel electrophoresis.	Acrylamide	158-168	gonadotropin releasing hormone receptor	Rattus norvegicus	115-129
985-3	1975	A 3 1/2-year-old girl with progressive mental and physical deterioration had decreased activities of arylsulfatases A and B in the leukocytes, shown by acylamide gel electrophoresis.	Acrylamide	152-161	arylsulfatase A	Homo sapiens	101-123
171259-5	1975	In the third step, the six cytochrome c oxidase subunits were separated from each other by dodecyl sulfate-acrylamide gel electrophoresis and scanned for radioactivity.	Acrylamide	107-117	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	27-47
1182204-3	1975	The antibody-enzyme complex was dissociated and glucose-6-phosphate dehydrogenase was isolated after electrophoresis on sodium dodecyl sulfate-acrylamide gels.	Acrylamide	143-153	glucose-6-phosphate dehydrogenase	Rattus norvegicus	48-81
765256-4	1975	The cyanogen bromide peptide pattern of [alpha1 (III)]3 on sodium dodecylsulfate acrylamide gel electrophoresis differed from that of alpha1 (I), alpha1 (II) and alpha2 chains.	Acrylamide	81-91	adrenoceptor alpha 1D	Homo sapiens	40-55
765256-4	1975	The cyanogen bromide peptide pattern of [alpha1 (III)]3 on sodium dodecylsulfate acrylamide gel electrophoresis differed from that of alpha1 (I), alpha1 (II) and alpha2 chains.	Acrylamide	81-91	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	41-47
1214136-0	1975	Phenotyping of haptoglobin on gradient acrylamide gel slabs using the Beckmann Microzone System.	Acrylamide	39-49	haptoglobin	Homo sapiens	15-26
1160228-4	1975	Its identity with human intestinal CaBP was suggested by acrylamid gel electrophoresis.	Acrylamide	57-66	centrin 1	Homo sapiens	35-39
1138863-4	1975	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated a molecular weight of 180,000 in the peak region of the CEA band for both 10 and 15% acrylamide.	Acrylamide	27-37	CEA cell adhesion molecule 3	Homo sapiens	124-127
123479-5	1975	Polypeptide analysis by acrylamide gel electrophoresis shows essentially the same patterns for F-1 and F-2 and only relatively minor differences between membrane components of tumor and normal tissues.	Acrylamide	24-34	coagulation factor II	Rattus norvegicus	95-106
4152066-0	1974	On the acrylamide disc electrophoresis pattern of human G6PD.	Acrylamide	7-17	glucose-6-phosphate dehydrogenase	Homo sapiens	56-60
1090666-4	1975	On disc gel electrophoresis at pH 9.1, peak LIF activity was eluted from the acrylamide gel fraction containing molecules that migrate with albumin.	Acrylamide	77-87	LIF interleukin 6 family cytokine	Homo sapiens	44-47
4420242-0	1974	[Determination of haptoglobin groups by acrylamide gel disk electrophoresis].	Acrylamide	40-50	haptoglobin	Homo sapiens	18-29
4603595-0	1974	[Identification of hereditary types of alpha-1-antitrypsin by acrylamide-agarose gel electrophoresis at pH 4.8].	Acrylamide	62-72	serpin family A member 1	Homo sapiens	39-58
4207639-0	1974	Visualization of catalase on acrylamide gels.	Acrylamide	29-39	catalase	Homo sapiens	17-25
4465098-0	1974	[Simultaneous determination of the quantity and type of haptoglobin by acrylamide electrophoresis].	Acrylamide	71-81	haptoglobin	Homo sapiens	56-67
4716090-0	1973	Separation of L-cystinyl-di- -naphthylamide hydrolase (oxytocinase) isoenzymes of human amniotic fluid by acrylamide gel electrophoresis.	Acrylamide	106-116	leucyl and cystinyl aminopeptidase	Homo sapiens	55-66
4545636-0	1974	Proceedings: Distribution of cholinesterase activity in the body wall of the annelid by acrylamide gel disc electrophoresis.	Acrylamide	88-98	butyrylcholinesterase	Homo sapiens	29-43
4519648-2	1973	In this study a discontinuous acrylamide-gel system containing sodium dodecyl sulfate was used to separate milligram quantities of alpha- and beta-tubulin from microtubules of chick-embryo brain and from outer doublets of sea-urchin sperm.	Acrylamide	30-40	tubulin alpha-5 chain	Gallus gallus	131-154
4633171-6	1973	Acrylamide gel electrophoresis revealed two bands of activity corresponding in Rx values to the T(1) and T(2) forms of soluble tyrosinase.	Acrylamide	0-10	tyrosinase	Mus musculus	127-137
4677941-0	1972	[Analysis of haptoglobin types by means of acrylamide gel disk vertical electrophoresis.	Acrylamide	43-53	haptoglobin	Homo sapiens	13-24
4689619-0	1973	The reduction of ferric myoglobin by ampholine on acrylamide gel electrofocusing.	Acrylamide	50-60	myoglobin	Homo sapiens	24-33
4115690-0	1972	Separation of L-cystinyl-di- -naphthylamide hydrolase ("oxytocinase") isoenzymes by acrylamide gel electrophoresis of human pregnancy sera.	Acrylamide	84-94	leucyl and cystinyl aminopeptidase	Homo sapiens	56-68
5288238-1	1971	Sodium dodecyl sulfate-acrylamide gel electrophoresis and molecular-sieve chromatography on 8% agarose demonstrate the existence of a very high molecular weight (500,000-600,000), proline-rich protein in cultured 3T6 fibroblasts that appears to be the precursor molecule (procollagen) of collagen.	Acrylamide	23-33	complement component 4 binding protein alpha	Homo sapiens	180-200
4106393-3	1971	Two bands were observed in the alpha-2 macroglobulin region when acrylamide gel electrophoresis was performed with a pH 8.9 running gel.	Acrylamide	65-75	alpha-2-macroglobulin	Homo sapiens	31-52
4106393-5	1971	In both cases, the preaddition of stoichiometric amounts of trypsin or chymotrypsin added to alpha-2 macroglobulin resulted in disappearance of slower bands leaving only one band on acrylamide gel electrophoresis patterns.	Acrylamide	182-192	alpha-2-macroglobulin	Homo sapiens	93-114
4106393-6	1971	Preparative acrylamide gel electrophoresis separated alpha-2 macroglobulin obtained from Bio-Gel into five closely-spaced species.	Acrylamide	12-22	alpha-2-macroglobulin	Homo sapiens	53-74
4106393-8	1971	Preparative acrylamide gel electrophoresis of a mixture of alpha-2 macroglobulin-trypsin complex and alpha-2 macroglobulin revealed that the fast moving component was alpha-2 macroglobulin-trypsin complex and that the slower moving material was unbound alpha-2 macroglobulin.	Acrylamide	12-22	alpha-2-macroglobulin	Homo sapiens	59-80
4106393-8	1971	Preparative acrylamide gel electrophoresis of a mixture of alpha-2 macroglobulin-trypsin complex and alpha-2 macroglobulin revealed that the fast moving component was alpha-2 macroglobulin-trypsin complex and that the slower moving material was unbound alpha-2 macroglobulin.	Acrylamide	12-22	alpha-2-macroglobulin	Homo sapiens	101-122
4106393-8	1971	Preparative acrylamide gel electrophoresis of a mixture of alpha-2 macroglobulin-trypsin complex and alpha-2 macroglobulin revealed that the fast moving component was alpha-2 macroglobulin-trypsin complex and that the slower moving material was unbound alpha-2 macroglobulin.	Acrylamide	12-22	alpha-2-macroglobulin	Homo sapiens	101-122
4106393-8	1971	Preparative acrylamide gel electrophoresis of a mixture of alpha-2 macroglobulin-trypsin complex and alpha-2 macroglobulin revealed that the fast moving component was alpha-2 macroglobulin-trypsin complex and that the slower moving material was unbound alpha-2 macroglobulin.	Acrylamide	12-22	alpha-2-macroglobulin	Homo sapiens	101-122
4106393-13	1971	These results were explained by the acrylamide gels which showed that 1 mole of chymotrypsin was sufficient to convert all the alpha-2 macroglobulin to a species with the fastest mobility which no longer binds additional enzyme.	Acrylamide	36-46	alpha-2-macroglobulin	Homo sapiens	127-148
4254313-0	1971	Acrylamide gel electrophoresis of fibrinogen and fibrin degradation products.	Acrylamide	0-10	fibrinogen beta chain	Homo sapiens	34-44
15776568-9	1971	C3c and C3d are similar to the beta1A and alpha2D produced by the aging of serum but differ in their mobilities in acrylamide gel and in agar.	Acrylamide	115-125	endogenous retrovirus group K member 13	Homo sapiens	8-11
4100685-6	1971	The electrophoretic mobility of purified C1r is that of a beta-globulin on disc acrylamide electrophoresis and on agarose electrophoresis at pH 8.6.	Acrylamide	80-90	complement C1r subcomponent	Oryctolagus cuniculus	41-44
4244455-5	1970	Agarose and acrylamide gel immunoelectrophoresis of a plasmin, inhibitor mixture showed the appearance of an additional precipitin band with immunologic reactivity similar to that of the untreated inhibitor.	Acrylamide	12-22	plasminogen	Homo sapiens	54-61
5163072-0	1971	Resolution by acrylamide gel electrophoresis of alkyl sulphatases and alcohol dehydrogenase.	Acrylamide	14-24	aldo-keto reductase family 1 member A1	Homo sapiens	70-91
5115891-0	1971	A note on disc-electrophoresis of human haptoglobin in acrylamide gel.	Acrylamide	55-65	haptoglobin	Homo sapiens	40-51
4189821-0	1970	Acrylamide gel electrophoresis of the S-sulfo derivatives of fibrinogen.	Acrylamide	0-10	fibrinogen beta chain	Homo sapiens	61-71
4310081-3	1969	After acrylamide gel electrophoresis, two bands exhibiting LDH activity were detected in crude or in partially purified cell-free extracts.	Acrylamide	6-16	AT695_RS04475	Staphylococcus aureus	59-62
5354620-0	1969	[Analysis of the content of somatotropin and LH of the anterior pituitary gland in the androgenized male rats with the aid of electrophoresis on acrylamide gel].	Acrylamide	145-155	growth hormone 1	Rattus norvegicus	28-40
5796334-0	1969	Acrylamide gel electrophoresis of aggregation and degradation products of myosin.	Acrylamide	0-10	myosin heavy chain 14	Homo sapiens	74-80
5758032-0	1968	An improved procedure for H-3 and C-14 counting in acrylamide gels with a nonaqueous scintillation system.	Acrylamide	51-61	H3 clustered histone 14	Homo sapiens	26-38
5240754-0	1968	Preliminary purification of sheep and mouse erythropoietin by vertical flat bed discontinous electrophoresis in acrylamide gel.	Acrylamide	112-122	erythropoietin	Mus musculus	44-58
4295240-7	1968	LDH forms (possibly isoenzymes) for each of 15 strains, which represent the five phage-propagating groups of the International-Blair series, were separated by acrylamide gel electrophoresis.	Acrylamide	159-169	AT695_RS04475	Staphylococcus aureus	0-3
5602977-1	1967	The intrinsic factor content of 263 samples of gastric juice was determined by immunoassay using charcoal absorption and by immunoelectrophoresis on acrylamide gel.	Acrylamide	149-159	cobalamin binding intrinsic factor	Homo sapiens	4-20
5921415-0	1966	Determination of serum-hemoglobin binding capacity and haptoglobin-type by acrylamide gel electrophoresis.	Acrylamide	75-85	haptoglobin	Homo sapiens	55-66
5916019-0	1966	Determination of serum-hemoglobin binding capacity and haptoglobin-type by acrylamide gel electrophoresis.	Acrylamide	75-85	haptoglobin	Homo sapiens	55-66
5897196-0	1965	[The possibilities of electrophoresis in acrylamide gel for the identification of blood stains by haptoglobin groups].	Acrylamide	41-51	haptoglobin	Homo sapiens	98-109
5897204-0	1965	[Demonstration of catalase on blood stains after electrophoresis in acrylamide gel.	Acrylamide	68-78	catalase	Homo sapiens	18-26
14169113-0	1964	A QUANTITATIVE STUDY OF ANTIGEN--ANTIBODY COMBINATION DURING DISK ELECTROPHORESIS IN ACRYLAMIDE GEL USING IODINE-131 LABELLED HUMAN GROWTH HORMONE.	Acrylamide	85-95	growth hormone 1	Homo sapiens	132-146
14072575-0	1963	IDENTIFICATION OF CATALASE FOLLOWING ELECTROPHORESIS ON ACRYLAMIDE GELS.	Acrylamide	56-66	catalase	Homo sapiens	18-26
11344575-8	1974	Acrylamide gel electrophoresis of mixtures of [121I]normal and [125I]abnormal fibrinogens revealed a slight increase in the anodal mobility of fibrinogen Philadelphia.	Acrylamide	0-10	fibrinogen beta chain	Homo sapiens	78-88
34030393-11	2021	We further found that increased CRP significantly (P < 0.05) mediated 6.34-11.1% of the urinary acrylamide metabolites-associated lung function reductions.	Acrylamide	96-106	C-reactive protein	Homo sapiens	32-35
34015226-2	2021	Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized.	Acrylamide	0-10	OTU deubiquitinase with linear linkage specificity	Homo sapiens	57-60
33711552-11	2021	The in vivo study with rat model demonstrated that Ac exposure significantly decline the hematological parameters, brain neurotransmitters concentrations and AChE activity, as well as levels of antioxidant biomarkers but markedly elevate the levels of oxidative stress biomarkers.	Acrylamide	51-53	acetylcholinesterase	Rattus norvegicus	158-162
33492591-6	2021	Furthermore, tissue analysis revealed marked increases in hepatic, renal, and brain MDA and NO, as well as marked reductions in the antioxidant biomarkers (GSH, GSH-Px, SOD, and CAT) in acrylamide-intoxicated rats.	Acrylamide	186-196	catalase	Rattus norvegicus	178-181
33872730-0	2021	Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice.	Acrylamide	59-69	nuclear factor, erythroid derived 2, like 2	Mus musculus	20-24
33872730-4	2021	The aim of this study was to determine the roles of Nrf2 in ACR-induced neurotoxicity including degeneration of monoaminergic axons and sensorimotor dysfunction.	Acrylamide	60-63	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
33872730-7	2021	Relative to the wild type, exposure of Nrf2-knockout mice to acrylamide increased hindlimb splay length, microglial area and process length as well as decreasing the density of NA and 5-HT-immunoreactive axons to a greater extent.	Acrylamide	61-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
34024031-0	2021	Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats.	Acrylamide	125-135	BCL2, apoptosis regulator	Rattus norvegicus	102-107
34024031-0	2021	Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats.	Acrylamide	125-135	BCL2 associated X, apoptosis regulator	Rattus norvegicus	112-115
34015226-11	2021	The results indicated that the A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.	Acrylamide	54-64	OTU deubiquitinase with linear linkage specificity	Homo sapiens	42-45
33722786-17	2021	STATEMENT OF SIGNIFICANCE: A new molecularly imprinted polymer (MIP) using human serum albumin (HSA) as a template was synthesized using N-isopropylacrylamide (NIPAM) as the main monomer; acrylamide (AAm), methacrylic acid (MAA), and dimethylaminoethyl methacrylate (DMAEMA) as functional monomers; and oligoglutamic acid-based peptide crosslinker as a crosslinker and cut into 1-mm cubes.	Acrylamide	148-158	albumin	Homo sapiens	87-94
33965515-7	2021	RESULTS: The data showed that ACR induced redox disruptions as measured by increased MDA levels and inhibition of CAT, SOD, and GPx antioxidant enzyme activities.	Acrylamide	30-33	catalase	Rattus norvegicus	114-117
33965515-9	2021	Furthermore, ACR administration caused a significant elevation of CTSD activity, indicating that ACR could trigger apoptosis or apoptosis-like death.	Acrylamide	13-16	cathepsin D	Rattus norvegicus	66-70
33965515-9	2021	Furthermore, ACR administration caused a significant elevation of CTSD activity, indicating that ACR could trigger apoptosis or apoptosis-like death.	Acrylamide	97-100	cathepsin D	Rattus norvegicus	66-70
34002274-3	2021	An MIP film for lysozyme was prepared by the copolymerization of {[2-(2-methacrylamido)ethyldithio]ethylcarbamoyl}methoxy acetic acid, a functional monomer possessing a modifiable disulfide bond, with acrylamide and N,N"-methylenebisacrylamide in the presence of lysozyme.	Acrylamide	201-211	lysozyme	Homo sapiens	16-24
33582169-0	2021	MiR-193b-5p protects BRL-3A cells from acrylamide-induced cell cycle arrest by targeting FoxO3.	Acrylamide	39-49	microRNA 193b	Rattus norvegicus	0-8
33607138-2	2021	Herein, we proposed an interpenetrating strategy in which N-isopropyl acrylamide (NIPAM) and acrylamide (AM) block copolymers were introduced as the second network into the carboxymethyl cellulose single network gel (CMC gel) to construct a dual-network robust hydrogel (CMC/PNIPAM-co-PAM).	Acrylamide	70-80	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	84-87
34055218-4	2021	Herein we report the development of compound 2, an acrylamide-based inhibitor of p300/CBP that forms a covalent adduct with C1450.	Acrylamide	51-61	E1A binding protein p300	Homo sapiens	81-85
34055218-4	2021	Herein we report the development of compound 2, an acrylamide-based inhibitor of p300/CBP that forms a covalent adduct with C1450.	Acrylamide	51-61	CREB binding protein	Homo sapiens	86-89
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	NAD(P)H dehydrogenase, quinone 1	Mus musculus	83-87
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	superoxide dismutase 1, soluble	Mus musculus	89-94
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	heme oxygenase 1	Mus musculus	99-103
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	arginase, liver	Mus musculus	115-119
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	resistin like alpha	Mus musculus	121-126
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	chitinase-like 3	Mus musculus	128-134
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	interleukin 4 receptor, alpha	Mus musculus	136-146
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	mannose receptor, C type 1	Mus musculus	148-153
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	transforming growth factor, beta 1	Mus musculus	158-166
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	interleukin 1 alpha	Mus musculus	218-226
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	tumor necrosis factor	Mus musculus	228-237
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	43-53	nitric oxide synthase 2, inducible	Mus musculus	242-246
33872730-8	2021	Moreover, deletion of Nrf2 gene suppressed acrylamide-induced mRNA upregulation of NQO1, SOD-1 and HO-1 as well as Arg1, Fizz1, Chi3l3, IL-4Ralpha, CD206 and TGFbeta1 while enhancing acrylamide-induced upregulation of IL-1beta, TNF-alpha and iNOS in the prefrontal cortex.	Acrylamide	183-193	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
33872730-9	2021	The results demonstrate susceptibility of mice lacking the Nrf2 gene to acrylamide-induced neurotoxicity and neuroinflammation with the activation of microglia.	Acrylamide	72-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
33582169-0	2021	MiR-193b-5p protects BRL-3A cells from acrylamide-induced cell cycle arrest by targeting FoxO3.	Acrylamide	39-49	forkhead box O3	Rattus norvegicus	89-94
33439429-8	2021	In addition, PSE markedly attenuated ACR-induced histopathological alterations in the cerebrum, cerebellum, hippocampus and sciatic nerve and downregulated the ACR-inclined GFAP expression.	Acrylamide	37-40	glial fibrillary acidic protein	Rattus norvegicus	173-177
33439429-8	2021	In addition, PSE markedly attenuated ACR-induced histopathological alterations in the cerebrum, cerebellum, hippocampus and sciatic nerve and downregulated the ACR-inclined GFAP expression.	Acrylamide	160-163	glial fibrillary acidic protein	Rattus norvegicus	173-177
33439429-10	2021	PSE upregulated the mRNA expression of protein kinase B (AKT), which resulted in an upsurge in its downstream cAMP response element-binding protein (CREB)/BDNF mRNA expression in the brain tissue of ACR-intoxicated rats.	Acrylamide	199-202	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
33439429-10	2021	PSE upregulated the mRNA expression of protein kinase B (AKT), which resulted in an upsurge in its downstream cAMP response element-binding protein (CREB)/BDNF mRNA expression in the brain tissue of ACR-intoxicated rats.	Acrylamide	199-202	cAMP responsive element binding protein 1	Rattus norvegicus	110-147
33439429-10	2021	PSE upregulated the mRNA expression of protein kinase B (AKT), which resulted in an upsurge in its downstream cAMP response element-binding protein (CREB)/BDNF mRNA expression in the brain tissue of ACR-intoxicated rats.	Acrylamide	199-202	cAMP responsive element binding protein 1	Rattus norvegicus	149-153
33439429-10	2021	PSE upregulated the mRNA expression of protein kinase B (AKT), which resulted in an upsurge in its downstream cAMP response element-binding protein (CREB)/BDNF mRNA expression in the brain tissue of ACR-intoxicated rats.	Acrylamide	199-202	brain-derived neurotrophic factor	Rattus norvegicus	155-159
33439429-12	2021	The current investigation confirmed the neuroprotective capacity of PSE against ACR-induced brain injury, and our findings indicate that AKT/CREB pathways and BDNF synthesis may play an important role in the PSE-mediated protective effects against ACR-triggered neurotoxicity.	Acrylamide	248-251	AKT serine/threonine kinase 1	Rattus norvegicus	137-140
33439429-12	2021	The current investigation confirmed the neuroprotective capacity of PSE against ACR-induced brain injury, and our findings indicate that AKT/CREB pathways and BDNF synthesis may play an important role in the PSE-mediated protective effects against ACR-triggered neurotoxicity.	Acrylamide	248-251	cAMP responsive element binding protein 1	Rattus norvegicus	141-145
33545342-3	2021	In this study, we have examined the interplay between CYP2E1, AMPK, ERK and PKC in acrylamide-induced neurotoxicity associated with autophagy in PC12 cells.	Acrylamide	83-93	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	54-60
33545342-3	2021	In this study, we have examined the interplay between CYP2E1, AMPK, ERK and PKC in acrylamide-induced neurotoxicity associated with autophagy in PC12 cells.	Acrylamide	83-93	Eph receptor B1	Rattus norvegicus	68-71
33545342-3	2021	In this study, we have examined the interplay between CYP2E1, AMPK, ERK and PKC in acrylamide-induced neurotoxicity associated with autophagy in PC12 cells.	Acrylamide	83-93	protein kinase C alpha	Homo sapiens	76-79
33545342-4	2021	Acrylamide-induced cell death was mediated by CYP2E1 expression and the activation of ERK, PKC-alpha and PKC-delta, whereas AMPK knockdown exacerbated the acrylamide-induced neurotoxic effects.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	46-52
33545342-4	2021	Acrylamide-induced cell death was mediated by CYP2E1 expression and the activation of ERK, PKC-alpha and PKC-delta, whereas AMPK knockdown exacerbated the acrylamide-induced neurotoxic effects.	Acrylamide	0-10	Eph receptor B1	Rattus norvegicus	86-89
33545342-4	2021	Acrylamide-induced cell death was mediated by CYP2E1 expression and the activation of ERK, PKC-alpha and PKC-delta, whereas AMPK knockdown exacerbated the acrylamide-induced neurotoxic effects.	Acrylamide	0-10	protein kinase C alpha	Homo sapiens	91-100
33545342-4	2021	Acrylamide-induced cell death was mediated by CYP2E1 expression and the activation of ERK, PKC-alpha and PKC-delta, whereas AMPK knockdown exacerbated the acrylamide-induced neurotoxic effects.	Acrylamide	0-10	protein kinase C delta	Homo sapiens	105-114
33545342-4	2021	Acrylamide-induced cell death was mediated by CYP2E1 expression and the activation of ERK, PKC-alpha and PKC-delta, whereas AMPK knockdown exacerbated the acrylamide-induced neurotoxic effects.	Acrylamide	155-165	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	124-128
33545342-7	2021	Furthermore, acrylamide increased autophagy with impaired autophagic flux, evidenced by the increased beclin-1, LC3-II and p62 protein.	Acrylamide	13-23	beclin 1	Homo sapiens	102-110
33484463-9	2021	Moreover, it is suggested that acrylamide"s molecular effect on SNARE core kinetics is carried out through the adduction of NSF and/or SNARE proteins.	Acrylamide	31-41	small NF90 (ILF3) associated RNA E	Homo sapiens	64-69
33484463-9	2021	Moreover, it is suggested that acrylamide"s molecular effect on SNARE core kinetics is carried out through the adduction of NSF and/or SNARE proteins.	Acrylamide	31-41	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	124-127
33484463-9	2021	Moreover, it is suggested that acrylamide"s molecular effect on SNARE core kinetics is carried out through the adduction of NSF and/or SNARE proteins.	Acrylamide	31-41	small NF90 (ILF3) associated RNA E	Homo sapiens	135-140
33484463-10	2021	Lately, scientists showed disruption of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) cell signaling pathways in human differentiating neuroblastoma SH-SY5Y cells, exposed to acrylamide.	Acrylamide	199-209	protein tyrosine kinase 2	Homo sapiens	40-61
33484463-10	2021	Lately, scientists showed disruption of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) cell signaling pathways in human differentiating neuroblastoma SH-SY5Y cells, exposed to acrylamide.	Acrylamide	199-209	protein tyrosine kinase 2	Homo sapiens	63-66
33484463-10	2021	Lately, scientists showed disruption of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) cell signaling pathways in human differentiating neuroblastoma SH-SY5Y cells, exposed to acrylamide.	Acrylamide	199-209	protein tyrosine kinase 2 beta	Homo sapiens	72-102
33484463-10	2021	Lately, scientists showed disruption of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) cell signaling pathways in human differentiating neuroblastoma SH-SY5Y cells, exposed to acrylamide.	Acrylamide	199-209	protein tyrosine kinase 2 beta	Homo sapiens	104-108
33995942-0	2021	Acrylamide exposure aggravates the development of ulcerative colitis in mice through activation of NF-kappaB, inflammatory cytokines, iNOS, and oxidative stress.	Acrylamide	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
33995942-0	2021	Acrylamide exposure aggravates the development of ulcerative colitis in mice through activation of NF-kappaB, inflammatory cytokines, iNOS, and oxidative stress.	Acrylamide	0-10	nitric oxide synthase 2, inducible	Mus musculus	134-138
33995942-7	2021	The mRNA expression of nuclear factor kappa B (NF-kappaB) and inducible nitric oxide synthase (iNOS) were further increased in colon tissue of mice exposed to acrylamide.	Acrylamide	159-169	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	23-45
33995942-7	2021	The mRNA expression of nuclear factor kappa B (NF-kappaB) and inducible nitric oxide synthase (iNOS) were further increased in colon tissue of mice exposed to acrylamide.	Acrylamide	159-169	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	47-56
33995942-7	2021	The mRNA expression of nuclear factor kappa B (NF-kappaB) and inducible nitric oxide synthase (iNOS) were further increased in colon tissue of mice exposed to acrylamide.	Acrylamide	159-169	nitric oxide synthase 2, inducible	Mus musculus	62-93
33995942-7	2021	The mRNA expression of nuclear factor kappa B (NF-kappaB) and inducible nitric oxide synthase (iNOS) were further increased in colon tissue of mice exposed to acrylamide.	Acrylamide	159-169	nitric oxide synthase 2, inducible	Mus musculus	95-99
33487136-10	2021	The results indicated that ACR can damage neurofilaments by affecting the contents and activities of CaM, CaMKII, PKA, cAMP, PKC, CDK5, and P35, which could result in ACR toxic neuropathy.	Acrylamide	27-30	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	114-117
33487136-10	2021	The results indicated that ACR can damage neurofilaments by affecting the contents and activities of CaM, CaMKII, PKA, cAMP, PKC, CDK5, and P35, which could result in ACR toxic neuropathy.	Acrylamide	27-30	protein kinase C, gamma	Rattus norvegicus	125-128
33487136-10	2021	The results indicated that ACR can damage neurofilaments by affecting the contents and activities of CaM, CaMKII, PKA, cAMP, PKC, CDK5, and P35, which could result in ACR toxic neuropathy.	Acrylamide	27-30	cyclin-dependent kinase 5	Rattus norvegicus	130-134
33487136-10	2021	The results indicated that ACR can damage neurofilaments by affecting the contents and activities of CaM, CaMKII, PKA, cAMP, PKC, CDK5, and P35, which could result in ACR toxic neuropathy.	Acrylamide	167-170	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	114-117
33487136-10	2021	The results indicated that ACR can damage neurofilaments by affecting the contents and activities of CaM, CaMKII, PKA, cAMP, PKC, CDK5, and P35, which could result in ACR toxic neuropathy.	Acrylamide	167-170	protein kinase C, gamma	Rattus norvegicus	125-128
33487136-10	2021	The results indicated that ACR can damage neurofilaments by affecting the contents and activities of CaM, CaMKII, PKA, cAMP, PKC, CDK5, and P35, which could result in ACR toxic neuropathy.	Acrylamide	167-170	cyclin-dependent kinase 5	Rattus norvegicus	130-134
33079732-2	2021	In our previous study, a new class of compounds containing pyrido[3,4-d]pyrimidine scaffold with an acrylamide moiety was designed as irreversible EGFR-tyrosine kinase inhibitors to overcome acquired EGFR-T790M resistance.	Acrylamide	100-110	epidermal growth factor receptor	Homo sapiens	147-151
33079732-2	2021	In our previous study, a new class of compounds containing pyrido[3,4-d]pyrimidine scaffold with an acrylamide moiety was designed as irreversible EGFR-tyrosine kinase inhibitors to overcome acquired EGFR-T790M resistance.	Acrylamide	100-110	epidermal growth factor receptor	Homo sapiens	200-204
33421551-4	2021	This study aims to explore whether microtubule-associated protein tau phosphorylation, excessive activation of protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway and BDNF decline are involved in cerebellar neuron lesions and motor dysfunction after subchronic ACR exposure.	Acrylamide	287-290	microtubule-associated protein tau	Rattus norvegicus	35-69
33421551-9	2021	Furthermore, ACR significantly decreased P-CREB at Ser133 and BDNF expression, which might be related to the inhibition of upstream signals from extracellular signal-related kinase (ERK) and protein kinase B (Akt).	Acrylamide	13-16	cAMP responsive element binding protein 1	Rattus norvegicus	43-47
33421551-9	2021	Furthermore, ACR significantly decreased P-CREB at Ser133 and BDNF expression, which might be related to the inhibition of upstream signals from extracellular signal-related kinase (ERK) and protein kinase B (Akt).	Acrylamide	13-16	brain-derived neurotrophic factor	Rattus norvegicus	62-66
33421551-9	2021	Furthermore, ACR significantly decreased P-CREB at Ser133 and BDNF expression, which might be related to the inhibition of upstream signals from extracellular signal-related kinase (ERK) and protein kinase B (Akt).	Acrylamide	13-16	Eph receptor B1	Rattus norvegicus	145-180
33421551-9	2021	Furthermore, ACR significantly decreased P-CREB at Ser133 and BDNF expression, which might be related to the inhibition of upstream signals from extracellular signal-related kinase (ERK) and protein kinase B (Akt).	Acrylamide	13-16	Eph receptor B1	Rattus norvegicus	182-185
33421551-9	2021	Furthermore, ACR significantly decreased P-CREB at Ser133 and BDNF expression, which might be related to the inhibition of upstream signals from extracellular signal-related kinase (ERK) and protein kinase B (Akt).	Acrylamide	13-16	AKT serine/threonine kinase 1	Rattus norvegicus	209-212
33792166-0	2021	Acrylamide Inhibits Vaccinia Virus Through Vimentin-independent Anti-Viral Granule Formation.	Acrylamide	0-10	vimentin	Homo sapiens	43-51
33792166-4	2021	The collapse of vimentin filaments, using acrylamide, was found to inhibit VACV infection at the level of genome replication, intermediate- and late- gene expression.	Acrylamide	42-52	vimentin	Homo sapiens	16-24
33855116-8	2021	This system presented here differs from the classical assays, in which an endpoint determination is performed via a denaturing acrylamide gel, by the possibility to measure the hOGG1 activity in real-time.	Acrylamide	127-137	8-oxoguanine DNA glycosylase	Homo sapiens	177-182
33545342-7	2021	Furthermore, acrylamide increased autophagy with impaired autophagic flux, evidenced by the increased beclin-1, LC3-II and p62 protein.	Acrylamide	13-23	nucleoporin 62	Homo sapiens	123-126
33545342-9	2021	Interestingly, PKC-delta siRNA, but not PKC-alpha siRNA, dramatically reduced acrylamide-induced beclin-1 and LC3-II levels, whereas AMPK siRNA further increased beclin-1, LC3-II and p62 protein levels.	Acrylamide	78-88	protein kinase C delta	Homo sapiens	15-24
33545342-9	2021	Interestingly, PKC-delta siRNA, but not PKC-alpha siRNA, dramatically reduced acrylamide-induced beclin-1 and LC3-II levels, whereas AMPK siRNA further increased beclin-1, LC3-II and p62 protein levels.	Acrylamide	78-88	beclin 1	Homo sapiens	97-105
33545342-9	2021	Interestingly, PKC-delta siRNA, but not PKC-alpha siRNA, dramatically reduced acrylamide-induced beclin-1 and LC3-II levels, whereas AMPK siRNA further increased beclin-1, LC3-II and p62 protein levels.	Acrylamide	78-88	nucleoporin 62	Homo sapiens	183-186
33545342-11	2021	Taken together, acrylamide- and glycidamide-induced neurotoxicity may involve cytotoxic autophagy, which is mediated by interplay between PKCs and AMPK pathways.	Acrylamide	16-26	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	147-151
33597036-0	2021	Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice.	Acrylamide	70-80	glutamic pyruvic transaminase, soluble	Mus musculus	84-87
33418285-4	2021	Exposure to acrylamide in maternal rats during the lactation period disturbed bone mineral density, serum levels of parathyroid hormone, and the expression of skeletal development-related genes in neonates.	Acrylamide	12-22	parathyroid hormone	Rattus norvegicus	116-135
33418285-6	2021	Furthermore, acrylamide intervention downregulated the expression of chondrocyte and osteoblast differentiation-related genes (sox9a, bmp2, col2a1, and runx2), and upregulated the expression of osteoclast marker genes (rankl and mcsf) in zebrafish and rat embryos at different gestational stages.	Acrylamide	13-23	SRY-box transcription factor 9a	Danio rerio	127-132
33418285-6	2021	Furthermore, acrylamide intervention downregulated the expression of chondrocyte and osteoblast differentiation-related genes (sox9a, bmp2, col2a1, and runx2), and upregulated the expression of osteoclast marker genes (rankl and mcsf) in zebrafish and rat embryos at different gestational stages.	Acrylamide	13-23	bone morphogenetic protein 2a	Danio rerio	134-138
33418285-6	2021	Furthermore, acrylamide intervention downregulated the expression of chondrocyte and osteoblast differentiation-related genes (sox9a, bmp2, col2a1, and runx2), and upregulated the expression of osteoclast marker genes (rankl and mcsf) in zebrafish and rat embryos at different gestational stages.	Acrylamide	13-23	collagen, type II, alpha 1a	Danio rerio	140-146
33418285-6	2021	Furthermore, acrylamide intervention downregulated the expression of chondrocyte and osteoblast differentiation-related genes (sox9a, bmp2, col2a1, and runx2), and upregulated the expression of osteoclast marker genes (rankl and mcsf) in zebrafish and rat embryos at different gestational stages.	Acrylamide	13-23	TNF superfamily member 11	Danio rerio	219-224
33569677-7	2021	Furthermore, the activity of TIMP-1 was measured by reverse zymography, where acrylamide gel was copolymerized with gelatin and recombinant MMP-2.	Acrylamide	78-88	TIMP metallopeptidase inhibitor 1	Homo sapiens	29-35
33569677-7	2021	Furthermore, the activity of TIMP-1 was measured by reverse zymography, where acrylamide gel was copolymerized with gelatin and recombinant MMP-2.	Acrylamide	78-88	matrix metallopeptidase 2	Homo sapiens	140-145
33567502-11	2021	Acrylamide induced histone H3K4 and H3K36 tri-methylation in an SDHA promoter and increased mitophagy-related PINK1 expression, which promoted a M2-like phenotypic switch with increase TGF-beta and CCL2 levels in THP-1 cells.	Acrylamide	0-10	PTEN induced kinase 1	Homo sapiens	110-115
33567502-10	2021	The gene expression of mitochondrial respiratory chain complex II SDHA was increased under acrylamide treatment.	Acrylamide	91-101	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	66-70
33567502-11	2021	Acrylamide induced histone H3K4 and H3K36 tri-methylation in an SDHA promoter and increased mitophagy-related PINK1 expression, which promoted a M2-like phenotypic switch with increase TGF-beta and CCL2 levels in THP-1 cells.	Acrylamide	0-10	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	64-68
33567502-11	2021	Acrylamide induced histone H3K4 and H3K36 tri-methylation in an SDHA promoter and increased mitophagy-related PINK1 expression, which promoted a M2-like phenotypic switch with increase TGF-beta and CCL2 levels in THP-1 cells.	Acrylamide	0-10	transforming growth factor alpha	Homo sapiens	185-193
33567502-11	2021	Acrylamide induced histone H3K4 and H3K36 tri-methylation in an SDHA promoter and increased mitophagy-related PINK1 expression, which promoted a M2-like phenotypic switch with increase TGF-beta and CCL2 levels in THP-1 cells.	Acrylamide	0-10	C-C motif chemokine ligand 2	Homo sapiens	198-202
33567502-12	2021	In conclusion, acrylamide induced ROS production through histone tri-methylation in an SDHA promoter and further increased the expression of mitophagy-related PINK-1, which was associated with a macrophage M2 polarization shift.	Acrylamide	15-25	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	87-91
33567502-12	2021	In conclusion, acrylamide induced ROS production through histone tri-methylation in an SDHA promoter and further increased the expression of mitophagy-related PINK-1, which was associated with a macrophage M2 polarization shift.	Acrylamide	15-25	PTEN induced kinase 1	Homo sapiens	159-165
33387696-0	2021	Design and synthesis of acrylate and acrylamide substituted pyrimidinediones as potential PPO herbicides.	Acrylamide	37-47	protoporphyrinogen oxidase	Homo sapiens	90-93
33387696-2	2021	In lieu with this, this study presents acrylate and acrylamide substituted pyrimidinediones as PPO herbicide candidates.	Acrylamide	52-62	protoporphyrinogen oxidase	Homo sapiens	95-98
33387696-5	2021	The synthesized acrylate and acrylamide substituted pyrimidinediones, especially, 5a could potentially be utilized in the development of commercial protoporphyrinogen oxidase inhibitors with further tests and studies.	Acrylamide	29-39	protoporphyrinogen oxidase	Homo sapiens	148-174
33348049-0	2021	Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver.	Acrylamide	19-29	NLR family, pyrin domain containing 3	Rattus norvegicus	38-43
32788470-2	2021	Brain-derived neurotrophic factor (BDNF) can alleviate acrylamide-induced synaptic injury; however, the underlying mechanism remains unclear.	Acrylamide	55-65	brain derived neurotrophic factor	Homo sapiens	0-33
33545815-6	2021	The monomers QQGWFGAGK(acrylamide) and acrylamide-GAGQQGWF were synthesized after identifying the QQGWF sequence as a binding motif for CD44 by phage display for the first time.	Acrylamide	23-33	CD44 molecule (Indian blood group)	Homo sapiens	136-140
33545815-6	2021	The monomers QQGWFGAGK(acrylamide) and acrylamide-GAGQQGWF were synthesized after identifying the QQGWF sequence as a binding motif for CD44 by phage display for the first time.	Acrylamide	39-49	CD44 molecule (Indian blood group)	Homo sapiens	136-140
33545815-7	2021	Our results demonstrate that UV-crosslinked coatings fabricated using the QQGWFGAGK(acrylamide) monomer are effective at selectively binding hMSC in the presence of HepG2 and HEK293 cells due to the difference in CD44 expression.	Acrylamide	84-94	CD44 molecule (Indian blood group)	Homo sapiens	213-217
32788470-0	2021	Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway.	Acrylamide	51-61	brain derived neurotrophic factor	Homo sapiens	0-33
32788470-0	2021	Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway.	Acrylamide	51-61	neurotrophic receptor tyrosine kinase 2	Homo sapiens	107-111
32788470-0	2021	Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway.	Acrylamide	51-61	mitogen-activated protein kinase 3	Homo sapiens	117-123
32979005-2	2021	During the course of screening more potent and selective BTK inhibitors, we discovered that, MM2-48, an Ibrutinib analogue which contains the alkynyl amide functional group in place of the acrylamide warhead, exhibits a much stronger cytotoxicity.	Acrylamide	189-199	Bruton tyrosine kinase	Homo sapiens	57-60
32788470-2	2021	Brain-derived neurotrophic factor (BDNF) can alleviate acrylamide-induced synaptic injury; however, the underlying mechanism remains unclear.	Acrylamide	55-65	brain derived neurotrophic factor	Homo sapiens	35-39
32788470-5	2021	Exposure of co-cultured NB-1 cells and Schwann cells to 0-100 mug/mL acrylamide for 48 hours resulted in upregulated expression of synapsin I and BDNF, suggesting that Schwann cells can activate self-protection of neurons.	Acrylamide	69-79	synapsin I	Homo sapiens	131-141
32788470-5	2021	Exposure of co-cultured NB-1 cells and Schwann cells to 0-100 mug/mL acrylamide for 48 hours resulted in upregulated expression of synapsin I and BDNF, suggesting that Schwann cells can activate self-protection of neurons.	Acrylamide	69-79	brain derived neurotrophic factor	Homo sapiens	146-150
32788470-9	2021	Therefore, exogenous BDNF may be an effective treatment strategy for acrylamide-induced nerve injury.	Acrylamide	69-79	brain derived neurotrophic factor	Homo sapiens	21-25
32886187-0	2020	Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts.	Acrylamide	16-26	tumor protein p53	Homo sapiens	52-56
33406544-0	2020	[The study of the protection function of the sphingosine kinase 1 in the nerve cell damage caused by acrylamide].	Acrylamide	101-111	sphingosine kinase 1	Homo sapiens	45-65
33406544-1	2020	Objective: To study the protective effect and effect of SphK1 overexpression on the injury of nerve cells induced by acrylamide.	Acrylamide	117-127	sphingosine kinase 1	Homo sapiens	56-61
33406544-13	2020	Conclusion: The SphK1 excessive expression plays the protective function to the nerve cell damage caused by acrylamide.	Acrylamide	108-118	sphingosine kinase 1	Homo sapiens	16-21
32705520-1	2020	Acrylamide/chitosan-based cryogel was fabricated, and a triazine dye, Reactive Green 5, was attached to the cryogel by nucleophilic substitution to build a dye affinity support for adsorption of catalase enzyme.	Acrylamide	0-10	catalase	Homo sapiens	195-203
33399867-14	2020	Cyp2e1, which catalyses the bioactivation of acrylamide to glycidamide, was not induced after acrylamide treatment.	Acrylamide	45-55	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
32886187-7	2020	Mutations induced by glycidamide occurred at specific TP53 codons that have also been found to be mutated in human tumours (i.e., breast, ovary, colorectal, and lung) previously associated with acrylamide exposure.	Acrylamide	194-204	tumor protein p53	Homo sapiens	54-58
32931911-3	2020	We report a crystal structure of MAP2K7 complexed with a potent covalent inhibitor bearing an acrylamide moiety as an electrophile, which discloses a structural basis for producing selective and potent MAP2K7 inhibitors.	Acrylamide	94-104	mitogen-activated protein kinase kinase 7	Homo sapiens	33-39
32592417-15	2020	Also, PUN increased the MBP level which was reduced due to ACR toxicity.	Acrylamide	59-62	myelin basic protein	Rattus norvegicus	24-27
33213219-11	2020	ACR increased Bax/Bcl-2 ratio and cleaved caspase-3.	Acrylamide	0-3	BCL2 associated X, apoptosis regulator	Rattus norvegicus	14-17
33213219-11	2020	ACR increased Bax/Bcl-2 ratio and cleaved caspase-3.	Acrylamide	0-3	BCL2, apoptosis regulator	Rattus norvegicus	18-23
33213219-11	2020	ACR increased Bax/Bcl-2 ratio and cleaved caspase-3.	Acrylamide	0-3	caspase 3	Rattus norvegicus	42-51
33198515-11	2020	Acrylamide at 10 mM concentration, without any significant change at lower concentrations, caused an increase in ubiquitinated protein, LC3B-II, and HSP70 levels and a decrease in mTOR phosphorylation.	Acrylamide	0-10	heat shock protein family A (Hsp70) member 4	Homo sapiens	149-154
33198515-11	2020	Acrylamide at 10 mM concentration, without any significant change at lower concentrations, caused an increase in ubiquitinated protein, LC3B-II, and HSP70 levels and a decrease in mTOR phosphorylation.	Acrylamide	0-10	mechanistic target of rapamycin kinase	Homo sapiens	180-184
33198515-13	2020	Our study showed that acrylamide at high concentration inhibits UPS and mTOR, activates autophagy, and increases HSP70 levels in HepG2 cells, and N-acetylcysteine reduces UPS inhibition and HSP70 levels in acrylamide-treated cells.	Acrylamide	22-32	mechanistic target of rapamycin kinase	Homo sapiens	72-76
33198515-13	2020	Our study showed that acrylamide at high concentration inhibits UPS and mTOR, activates autophagy, and increases HSP70 levels in HepG2 cells, and N-acetylcysteine reduces UPS inhibition and HSP70 levels in acrylamide-treated cells.	Acrylamide	22-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	113-118
33198515-13	2020	Our study showed that acrylamide at high concentration inhibits UPS and mTOR, activates autophagy, and increases HSP70 levels in HepG2 cells, and N-acetylcysteine reduces UPS inhibition and HSP70 levels in acrylamide-treated cells.	Acrylamide	22-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	190-195
32931911-3	2020	We report a crystal structure of MAP2K7 complexed with a potent covalent inhibitor bearing an acrylamide moiety as an electrophile, which discloses a structural basis for producing selective and potent MAP2K7 inhibitors.	Acrylamide	94-104	mitogen-activated protein kinase kinase 7	Homo sapiens	202-208
32827546-7	2020	Morin also alleviated the side effects caused by AC by regulating the PI3K/Akt/mTOR signaling pathway.	Acrylamide	49-51	AKT serine/threonine kinase 1	Rattus norvegicus	75-78
32827546-7	2020	Morin also alleviated the side effects caused by AC by regulating the PI3K/Akt/mTOR signaling pathway.	Acrylamide	49-51	mechanistic target of rapamycin kinase	Rattus norvegicus	79-83
32805340-0	2020	Acrylamide induces NLRP3 inflammasome activation via oxidative stress- and endoplasmic reticulum stress-mediated MAPK pathway in HepG2 cells.	Acrylamide	0-10	NLR family pyrin domain containing 3	Homo sapiens	19-24
33158221-0	2020	Influence of Buffers, Ionic Strength, and pH on the Volume Phase Transition Behavior of Acrylamide-Based Nanogels.	Acrylamide	88-98	phenylalanine hydroxylase	Homo sapiens	42-44
32982756-0	2020	Notoginsenoside R1 Protects Against the Acrylamide-Induced Neurotoxicity via Upregulating Trx-1-Mediated ITGAV Expression: Involvement of Autophagy.	Acrylamide	40-50	thioredoxin 1	Rattus norvegicus	90-95
33028897-0	2020	Acrylamide alters CREB and retinoic acid signalling pathways during differentiation of the human neuroblastoma SH-SY5Y cell line.	Acrylamide	0-10	cAMP responsive element binding protein 1	Homo sapiens	18-22
33028897-5	2020	Next, by qPCR we showed that 1 and 70 microM ACR after 9 days exposure alter the expression of 13 out of 36 genes in the RAR activation pathway and 18 out of 47 in the CREB signalling pathway.	Acrylamide	45-48	cAMP responsive element binding protein 1	Homo sapiens	168-172
32608003-10	2020	Acrylamide intoxication was associated with significant (p < 0.05) increases in serum levels of liver injury biomarkers (alanine transferase, aspartate transferase, and alkaline phosphatase), renal function products (urea, creatinine), DNA oxidative damage biomarker (8-oxo-2"-deoxyguanosine), and pro-inflammatory biomarkers (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha).	Acrylamide	0-10	interleukin 1 beta	Rattus norvegicus	327-344
32608003-10	2020	Acrylamide intoxication was associated with significant (p < 0.05) increases in serum levels of liver injury biomarkers (alanine transferase, aspartate transferase, and alkaline phosphatase), renal function products (urea, creatinine), DNA oxidative damage biomarker (8-oxo-2"-deoxyguanosine), and pro-inflammatory biomarkers (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha).	Acrylamide	0-10	interleukin 6	Rattus norvegicus	346-359
32608003-10	2020	Acrylamide intoxication was associated with significant (p < 0.05) increases in serum levels of liver injury biomarkers (alanine transferase, aspartate transferase, and alkaline phosphatase), renal function products (urea, creatinine), DNA oxidative damage biomarker (8-oxo-2"-deoxyguanosine), and pro-inflammatory biomarkers (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha).	Acrylamide	0-10	tumor necrosis factor	Rattus norvegicus	365-392
32763439-6	2020	The results indicated that exposure to ACR significantly altered the transcriptional profile, increased nuclear factor erythroid 2-related factor 2 (NRF2)-mediated gene expression, induced cell apoptosis, repressed neuronal differentiation, and promoted tau hyperphosphorylation in cerebral organoids, which may contribute to ACR-induced neurodevelopmental toxicity.	Acrylamide	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	104-147
32763439-6	2020	The results indicated that exposure to ACR significantly altered the transcriptional profile, increased nuclear factor erythroid 2-related factor 2 (NRF2)-mediated gene expression, induced cell apoptosis, repressed neuronal differentiation, and promoted tau hyperphosphorylation in cerebral organoids, which may contribute to ACR-induced neurodevelopmental toxicity.	Acrylamide	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
32763439-6	2020	The results indicated that exposure to ACR significantly altered the transcriptional profile, increased nuclear factor erythroid 2-related factor 2 (NRF2)-mediated gene expression, induced cell apoptosis, repressed neuronal differentiation, and promoted tau hyperphosphorylation in cerebral organoids, which may contribute to ACR-induced neurodevelopmental toxicity.	Acrylamide	326-329	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
32786533-2	2020	DOX enhances the polymerization rates of a broad range of monomers, including acrylamide, acrylate and methacrylates, allowing for high monomer conversion and well-defined molecular weights under irradiation with blue LED light (lambdamax = 485 nm, 2.2 mW/cm2).	Acrylamide	78-88	small integral membrane protein 10 like 2A	Homo sapiens	218-221
32597654-4	2020	Two distinct readily available electrophiles, namely Csp2- and Csp3- halides are added simultaneously across a variety of olefins (vinyl amides, vinyl boranes, vinyl phosphates) at room temperature in a highly regio- and enantioselec-tive manner.	Acrylamide	131-143	regulator of calcineurin 2	Homo sapiens	53-57
32339852-0	2020	Exposure to acrylamide and reduced heart rate variability: The mediating role of transforming growth factor-beta.	Acrylamide	12-22	tumor necrosis factor	Homo sapiens	81-112
32339852-6	2020	We found significantly negative dose-response relationships of all urinary acrylamide metabolites and TGF-beta1 with all six HRV indices after adjusting for potential confounders (all P < 0.05).	Acrylamide	75-85	transforming growth factor beta 1	Homo sapiens	102-111
32339852-8	2020	Our findings suggest for the first time that daily exposure of general population to acrylamide is associated with cardiac autonomic dysfunction, where a mechanism involving TGF-beta pathway may be involved.	Acrylamide	85-95	transforming growth factor alpha	Homo sapiens	174-182
32812964-9	2020	AOB-w accelerated the metabolism of hemoglobin adducts of acrylamide and glycidamide in blood of women.	Acrylamide	58-68	hemoglobin	Solanum tuberosum	36-46
32812964-10	2020	Compared with the baseline levels on the beginning day, we observed a significant enhancement of hemoglobin adducts on the 10th day after serving them potato chips, showing 54.5% and 20.9% higher levels of the hemoglobin adducts of acrylamide and glycidamide, respectively, which thus indicated a lower level of glycidamide-to-acrylamide ratio in blood of participants.	Acrylamide	232-242	hemoglobin	Solanum tuberosum	97-107
32812964-10	2020	Compared with the baseline levels on the beginning day, we observed a significant enhancement of hemoglobin adducts on the 10th day after serving them potato chips, showing 54.5% and 20.9% higher levels of the hemoglobin adducts of acrylamide and glycidamide, respectively, which thus indicated a lower level of glycidamide-to-acrylamide ratio in blood of participants.	Acrylamide	232-242	hemoglobin	Solanum tuberosum	210-220
32812964-10	2020	Compared with the baseline levels on the beginning day, we observed a significant enhancement of hemoglobin adducts on the 10th day after serving them potato chips, showing 54.5% and 20.9% higher levels of the hemoglobin adducts of acrylamide and glycidamide, respectively, which thus indicated a lower level of glycidamide-to-acrylamide ratio in blood of participants.	Acrylamide	327-337	hemoglobin	Solanum tuberosum	97-107
32812964-10	2020	Compared with the baseline levels on the beginning day, we observed a significant enhancement of hemoglobin adducts on the 10th day after serving them potato chips, showing 54.5% and 20.9% higher levels of the hemoglobin adducts of acrylamide and glycidamide, respectively, which thus indicated a lower level of glycidamide-to-acrylamide ratio in blood of participants.	Acrylamide	327-337	hemoglobin	Solanum tuberosum	210-220
33078092-0	2020	Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis.	Acrylamide	68-78	dihydroorotate dehydrogenase (quinone)	Homo sapiens	121-149
33078092-2	2020	Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized.	Acrylamide	20-30	dihydroorotate dehydrogenase (quinone)	Homo sapiens	43-48
33178677-0	2020	Covalent Immobilization of L-Asparaginase and Optimization of Its Enzyme Reactor for Reducing Acrylamide Formation in a Heated Food Model System.	Acrylamide	94-104	asparaginase and isoaspartyl peptidase 1	Homo sapiens	27-41
33178677-2	2020	In this work, a food safety immobilization system for L-asparaginase (L-ASNase) consisting of food-grade agarose (Aga) spheres and N-hydroxysuccinimide esters was developed to decrease the formation of acrylamide in a fluid food model system.	Acrylamide	202-212	asparaginase and isoaspartyl peptidase 1	Homo sapiens	54-68
33178677-2	2020	In this work, a food safety immobilization system for L-asparaginase (L-ASNase) consisting of food-grade agarose (Aga) spheres and N-hydroxysuccinimide esters was developed to decrease the formation of acrylamide in a fluid food model system.	Acrylamide	202-212	asparaginase and isoaspartyl peptidase 1	Homo sapiens	70-78
32872507-7	2020	Acrylamide reduction in the roasted coffee beans strongly correlated with the change in antioxidant capacities after roasting ( FRAP, 0.858;  DPPH, 0.836).	Acrylamide	0-10	mechanistic target of rapamycin kinase	Homo sapiens	128-132
32811563-15	2020	Maintaining TERT-related anti-apoptotic function might be one mechanism underlying the protective effect of curcumin on ACR-intoxicated brains.	Acrylamide	120-123	telomerase reverse transcriptase	Rattus norvegicus	12-16
32982756-7	2020	NR1 could resist the ACR-induced neurotoxicity by upregulating thioredoxin-1 in PC12 cells and mice.	Acrylamide	21-24	thioredoxin 1	Rattus norvegicus	63-76
32982756-9	2020	Besides, we also found that overexpression of Trx-1 resisted ACR-induced autophagy in PC12 cells and downregulation of Trx-1 triggered autophagy induced by ACR in PC12 cells.	Acrylamide	61-64	thioredoxin 1	Rattus norvegicus	46-51
32982756-9	2020	Besides, we also found that overexpression of Trx-1 resisted ACR-induced autophagy in PC12 cells and downregulation of Trx-1 triggered autophagy induced by ACR in PC12 cells.	Acrylamide	156-159	thioredoxin 1	Rattus norvegicus	119-124
31954377-5	2020	The removal of asparagine by L-asparaginase leads to the reduction of acrylamide formation in fried food items.	Acrylamide	70-80	asparaginase and isoaspartyl peptidase 1	Homo sapiens	29-43
32493819-8	2020	However, chemical disruption of the vimentin network by acrylamide resulted in a significant decrease in viral yield, suggesting that an intact vimentin network is needed for FMDV replication.	Acrylamide	56-66	vimentin	Homo sapiens	36-44
32304918-8	2020	Compared with the control condition, high doses of ACR (50 mg/kg/day) significantly induced the overexpression of INSL3, CYP17a, IGF1, ESR1, ESR2, ATG5, ATG12 and LC3 in the ovary.	Acrylamide	51-54	annexin A3	Rattus norvegicus	163-166
32304918-8	2020	Compared with the control condition, high doses of ACR (50 mg/kg/day) significantly induced the overexpression of INSL3, CYP17a, IGF1, ESR1, ESR2, ATG5, ATG12 and LC3 in the ovary.	Acrylamide	51-54	insulin-like 3	Rattus norvegicus	114-119
32304918-8	2020	Compared with the control condition, high doses of ACR (50 mg/kg/day) significantly induced the overexpression of INSL3, CYP17a, IGF1, ESR1, ESR2, ATG5, ATG12 and LC3 in the ovary.	Acrylamide	51-54	insulin-like growth factor 1	Rattus norvegicus	129-133
32304918-8	2020	Compared with the control condition, high doses of ACR (50 mg/kg/day) significantly induced the overexpression of INSL3, CYP17a, IGF1, ESR1, ESR2, ATG5, ATG12 and LC3 in the ovary.	Acrylamide	51-54	estrogen receptor 1	Rattus norvegicus	135-139
32304918-8	2020	Compared with the control condition, high doses of ACR (50 mg/kg/day) significantly induced the overexpression of INSL3, CYP17a, IGF1, ESR1, ESR2, ATG5, ATG12 and LC3 in the ovary.	Acrylamide	51-54	estrogen receptor 2	Rattus norvegicus	141-145
32304918-8	2020	Compared with the control condition, high doses of ACR (50 mg/kg/day) significantly induced the overexpression of INSL3, CYP17a, IGF1, ESR1, ESR2, ATG5, ATG12 and LC3 in the ovary.	Acrylamide	51-54	autophagy related 5	Rattus norvegicus	147-151
32304918-8	2020	Compared with the control condition, high doses of ACR (50 mg/kg/day) significantly induced the overexpression of INSL3, CYP17a, IGF1, ESR1, ESR2, ATG5, ATG12 and LC3 in the ovary.	Acrylamide	51-54	autophagy related 12	Rattus norvegicus	153-158
32482111-3	2022	The biochemical assays exhibited a significant increase in serum levels of Adiponectin, AST, ALT, ALP of the group treated with acrylamide if compared to the control group and an improvement in their levels of groups V and VI.	Acrylamide	128-138	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	75-86
32482111-3	2022	The biochemical assays exhibited a significant increase in serum levels of Adiponectin, AST, ALT, ALP of the group treated with acrylamide if compared to the control group and an improvement in their levels of groups V and VI.	Acrylamide	128-138	PDZ and LIM domain 3	Rattus norvegicus	98-101
31971015-0	2020	Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.	Acrylamide	71-81	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	27-45
31971015-0	2020	Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.	Acrylamide	71-81	thioredoxin 1	Rattus norvegicus	62-67
31971015-5	2020	Our results have shown that NR1 resisted the neurotoxicity induced by ACR by upregulating the levels of thioredoxin-1 (Trx-1) in Rat adrenal chromaffin cell tumor (PC12) cells.	Acrylamide	70-73	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	28-31
31971015-5	2020	Our results have shown that NR1 resisted the neurotoxicity induced by ACR by upregulating the levels of thioredoxin-1 (Trx-1) in Rat adrenal chromaffin cell tumor (PC12) cells.	Acrylamide	70-73	thioredoxin 1	Rattus norvegicus	104-117
31971015-5	2020	Our results have shown that NR1 resisted the neurotoxicity induced by ACR by upregulating the levels of thioredoxin-1 (Trx-1) in Rat adrenal chromaffin cell tumor (PC12) cells.	Acrylamide	70-73	thioredoxin 1	Rattus norvegicus	119-124
32412754-4	2020	A potent covalent inhibitor of JAK3 kinase was identified with superior selectivity across the kinome and improvements in in vitro pharmacokinetic profile relative to the related acrylamide-based inhibitor.	Acrylamide	179-189	Janus kinase 3	Homo sapiens	31-35
32412754-5	2020	In addition, the use of a novel heterocycle as cysteine reactive warhead is employed to target Cys788 in c-KIT where acrylamide has previously failed to form covalent interactions.	Acrylamide	117-127	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	105-110
32304918-9	2020	Moreover, LC3 mRNA levels significantly increased with increasing doses of ACR (2.5, 10 and 50 mg/kg/day), suggesting that ACR treatment induced autophagy.	Acrylamide	75-78	annexin A3	Rattus norvegicus	10-13
32304918-9	2020	Moreover, LC3 mRNA levels significantly increased with increasing doses of ACR (2.5, 10 and 50 mg/kg/day), suggesting that ACR treatment induced autophagy.	Acrylamide	123-126	annexin A3	Rattus norvegicus	10-13
32366087-1	2020	Novel gas-responsive imprinting hydrogel were fabricated by combining N,N"-dimethylaminoethyl methacrylate (DMAEMA) gas-sensitive monomer, N,N"-methylenebis(acrylamide) (MBAAm) cross-linker and human serum albumin (HSA) template proteins via a free radical polymerization.	Acrylamide	157-167	gastrin	Homo sapiens	6-9
32366087-1	2020	Novel gas-responsive imprinting hydrogel were fabricated by combining N,N"-dimethylaminoethyl methacrylate (DMAEMA) gas-sensitive monomer, N,N"-methylenebis(acrylamide) (MBAAm) cross-linker and human serum albumin (HSA) template proteins via a free radical polymerization.	Acrylamide	157-167	albumin	Homo sapiens	200-213
32014472-0	2020	NLRP3 inflammasome inhibition attenuates subacute neurotoxicity induced by acrylamide in vitro and in vivo.	Acrylamide	75-85	NLR family, pyrin domain containing 3	Mus musculus	0-5
32147541-0	2020	Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment.	Acrylamide	8-18	NLR family, pyrin domain containing 3	Rattus norvegicus	58-63
32147541-4	2020	This study aimed to explore whether chronic acrylamide exposure induced neuronal lesions, microglial activation, NLRP3 inflammasome-mediated neuroinflammation and cognitive impairment.	Acrylamide	44-54	NLR family, pyrin domain containing 3	Rattus norvegicus	113-118
32337443-2	2020	The investigation showed that the adsorption efficiency of Pb(II) was the best when the acrylamide/acrylic acid (AM/AA) mass ratio of composites was 5:5.	Acrylamide	88-98	submaxillary gland androgen regulated protein 3B	Homo sapiens	59-65
31954717-9	2020	Acrylamide quenching of Pgp tryptophan fluorescence to probe the tertiary structure of Pgp suggested that DNR shifts Pgp to a "closed" conformation, while DOX shifts Pgp to an "intermediate" conformation.	Acrylamide	0-10	phosphoglycolate phosphatase	Mus musculus	24-27
31954717-9	2020	Acrylamide quenching of Pgp tryptophan fluorescence to probe the tertiary structure of Pgp suggested that DNR shifts Pgp to a "closed" conformation, while DOX shifts Pgp to an "intermediate" conformation.	Acrylamide	0-10	phosphoglycolate phosphatase	Mus musculus	87-90
31954717-9	2020	Acrylamide quenching of Pgp tryptophan fluorescence to probe the tertiary structure of Pgp suggested that DNR shifts Pgp to a "closed" conformation, while DOX shifts Pgp to an "intermediate" conformation.	Acrylamide	0-10	phosphoglycolate phosphatase	Mus musculus	87-90
31954717-9	2020	Acrylamide quenching of Pgp tryptophan fluorescence to probe the tertiary structure of Pgp suggested that DNR shifts Pgp to a "closed" conformation, while DOX shifts Pgp to an "intermediate" conformation.	Acrylamide	0-10	phosphoglycolate phosphatase	Mus musculus	87-90
32068001-8	2020	Histopathological changes and immunohistochemical expressions of p53, EGFR, nephrin and AQP2 in the ACR-induced liver and kidney tissues were decreased after administration of morin.	Acrylamide	100-103	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	65-68
32068001-8	2020	Histopathological changes and immunohistochemical expressions of p53, EGFR, nephrin and AQP2 in the ACR-induced liver and kidney tissues were decreased after administration of morin.	Acrylamide	100-103	epidermal growth factor receptor	Rattus norvegicus	70-74
32068001-8	2020	Histopathological changes and immunohistochemical expressions of p53, EGFR, nephrin and AQP2 in the ACR-induced liver and kidney tissues were decreased after administration of morin.	Acrylamide	100-103	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	76-83
32068001-8	2020	Histopathological changes and immunohistochemical expressions of p53, EGFR, nephrin and AQP2 in the ACR-induced liver and kidney tissues were decreased after administration of morin.	Acrylamide	100-103	aquaporin 2	Rattus norvegicus	88-92
32068001-10	2020	Morin also affected the protein levels by regulating the PI3K/Akt/mTOR signaling pathway and thus alleviated ACR-induced apoptosis and autophagy.	Acrylamide	109-112	AKT serine/threonine kinase 1	Rattus norvegicus	62-65
32225044-0	2020	Effect of Acrylamide Supplementation on the CART-, VAChT-, and nNOS-Immunoreactive Nervous Structures in the Porcine Stomach.	Acrylamide	10-20	solute carrier family 18 member A3	Homo sapiens	51-56
32225044-0	2020	Effect of Acrylamide Supplementation on the CART-, VAChT-, and nNOS-Immunoreactive Nervous Structures in the Porcine Stomach.	Acrylamide	10-20	nitric oxide synthase 1	Homo sapiens	63-67
32225044-2	2020	The aim of this investigation was to demonstrate the changes in the population of CART-, nNOS-, and VAChT-immunoreactive enteric neurons in the porcine stomach in response to supplementation of low and high acrylamide doses.	Acrylamide	207-217	nitric oxide synthase 1	Homo sapiens	89-93
32225044-2	2020	The aim of this investigation was to demonstrate the changes in the population of CART-, nNOS-, and VAChT-immunoreactive enteric neurons in the porcine stomach in response to supplementation of low and high acrylamide doses.	Acrylamide	207-217	solute carrier family 18 member A3	Homo sapiens	100-105
32225044-5	2020	Using the double immunofluorescence staining method, it was established that supplementation with low and high doses of acrylamide resulted in alterations of the porcine stomach neuron phenotype, which was reflected in an increased number of CART-, VAChT-, and nNOS-immunoreactive neurons.	Acrylamide	120-130	solute carrier family 18 member A3	Homo sapiens	249-254
32225044-5	2020	Using the double immunofluorescence staining method, it was established that supplementation with low and high doses of acrylamide resulted in alterations of the porcine stomach neuron phenotype, which was reflected in an increased number of CART-, VAChT-, and nNOS-immunoreactive neurons.	Acrylamide	120-130	nitric oxide synthase 1	Homo sapiens	261-265
31971015-6	2020	NR1 inhibited the increase in levels of Bax, caspase-9, and caspase-3, which was instigated by ACR.	Acrylamide	95-98	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	0-3
31971015-6	2020	NR1 inhibited the increase in levels of Bax, caspase-9, and caspase-3, which was instigated by ACR.	Acrylamide	95-98	BCL2 associated X, apoptosis regulator	Rattus norvegicus	40-43
31971015-6	2020	NR1 inhibited the increase in levels of Bax, caspase-9, and caspase-3, which was instigated by ACR.	Acrylamide	95-98	caspase 9	Rattus norvegicus	45-54
31971015-6	2020	NR1 inhibited the increase in levels of Bax, caspase-9, and caspase-3, which was instigated by ACR.	Acrylamide	95-98	caspase 3	Rattus norvegicus	60-69
31971015-7	2020	Moreover, NR1 inhibited the decrease in levels of B-cell lymphoma 2 and Trx-1 induced by ACR.	Acrylamide	89-92	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	10-13
31971015-7	2020	Moreover, NR1 inhibited the decrease in levels of B-cell lymphoma 2 and Trx-1 induced by ACR.	Acrylamide	89-92	thioredoxin 1	Rattus norvegicus	72-77
31971015-8	2020	The downregulation of Trx-1 aggravated the mitochondrial-mediated apoptosis and increased the expression of the above molecules, which was induced by ACR.	Acrylamide	150-153	thioredoxin 1	Rattus norvegicus	22-27
31971015-9	2020	In contrast, overexpression of Trx-1 attenuated the mitochondrial-mediated apoptosis and inhibited the expression of the mentioned molecules induced by ACR.	Acrylamide	152-155	thioredoxin 1	Rattus norvegicus	31-36
31971015-10	2020	Our results suggested that NR1 protected ACR-induced mitochondrial apoptosis by upregulating Trx-1.	Acrylamide	41-44	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	27-30
31971015-10	2020	Our results suggested that NR1 protected ACR-induced mitochondrial apoptosis by upregulating Trx-1.	Acrylamide	41-44	thioredoxin 1	Rattus norvegicus	93-98
32383547-0	2020	Protective effect of carnosic acid on acrylamide-induced liver toxicity in rats: Mechanistic approach over Nrf2-Keap1 pathway.	Acrylamide	38-48	Kelch-like ECH-associated protein 1	Rattus norvegicus	112-117
32383547-7	2020	As a result, acrylamide reduced bodyweight, liver weight, catalase, and total antioxidant capacity levels but increased alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, malondialdehyde, total oxidant status, oxidative stress index levels, Nrf2, and Keap1 protein levels.	Acrylamide	13-23	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	146-172
32383547-7	2020	As a result, acrylamide reduced bodyweight, liver weight, catalase, and total antioxidant capacity levels but increased alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, malondialdehyde, total oxidant status, oxidative stress index levels, Nrf2, and Keap1 protein levels.	Acrylamide	13-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	266-270
32383547-7	2020	As a result, acrylamide reduced bodyweight, liver weight, catalase, and total antioxidant capacity levels but increased alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, malondialdehyde, total oxidant status, oxidative stress index levels, Nrf2, and Keap1 protein levels.	Acrylamide	13-23	Kelch-like ECH-associated protein 1	Rattus norvegicus	276-281
32227030-4	2020	To date, the acrylamide group remains the predominantly employed electrophile in CKI development, with its incorporation in the majority of clinical candidates and FDA approved covalent therapies.	Acrylamide	13-23	choline kinase alpha	Homo sapiens	81-84
31818667-0	2020	Exposure to acrylamide inhibits uterine decidualization via suppression of cyclin D3/p21 and apoptosis in mice.	Acrylamide	12-22	cyclin D3	Mus musculus	75-84
31818667-0	2020	Exposure to acrylamide inhibits uterine decidualization via suppression of cyclin D3/p21 and apoptosis in mice.	Acrylamide	12-22	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	85-88
31818667-9	2020	In summary, ACR exposure significantly inhibited uterine endometrial decidualization via the apoptosis and suppression of cyclin D3/p21 in mice.	Acrylamide	12-15	cyclin D3	Mus musculus	122-131
31818667-9	2020	In summary, ACR exposure significantly inhibited uterine endometrial decidualization via the apoptosis and suppression of cyclin D3/p21 in mice.	Acrylamide	12-15	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	132-135
31697219-6	2020	The levels of acrylamide ranged from 16.5 to 79.5 ng mL-1 in instant coffees, from 5.9 to 38.8 ng mL-1 in ready-to-drink (brewed) coffees and from 5.3-54.8 ng mL-1 in Turkish coffee and other traditional coffees.	Acrylamide	14-24	L1 cell adhesion molecule	Mus musculus	53-57
31728856-14	2020	TQ reversed the alterations in the protein contents of MAP kinase and apoptosis signaling pathways as well as MBP and GFAP contents, induced by ACR.	Acrylamide	144-147	myelin basic protein	Rattus norvegicus	110-113
31728856-14	2020	TQ reversed the alterations in the protein contents of MAP kinase and apoptosis signaling pathways as well as MBP and GFAP contents, induced by ACR.	Acrylamide	144-147	glial fibrillary acidic protein	Rattus norvegicus	118-122
31822471-12	2019	Suppression of CK by acrylamide in XtiSCs led to breakdown of membrane-bound beta-catenin but not F-actin and beta-tubulin or cell adhesion proteins (Focal adhesion kinase and integrin beta1).	Acrylamide	21-31	catenin beta 1	Xenopus tropicalis	77-89
32054058-1	2020	Dual antifouling and antibacterial polysulfone(PSf)/polyethersulfone(PES) hybrid membranes were developed by the synergy of capsaicin-mimic N-(5-methyl acrylamide-2,3,4 hydroxy benzyl) acrylamide (AMTHBA) and vinyl triethylene (b-methoxy ethoxy) silane (VTMES).	Acrylamide	140-195	insulin like growth factor binding protein 7	Homo sapiens	47-50
32218969-1	2020	A novel hydrophobic and cationic cyclodextrin-based acrylamide flocculant (AM-beta-CD-DMDAAC) was prepared by chemical oxidative polymerization to adsorb water-soluble dyes in dye wastewater.	Acrylamide	52-62	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
31941973-3	2020	We detected the formation of acrylamide adducts with thiol groups from both metabolites and protein residues, leading to a quasi-complete depletion of glutathione and to the inactivation of different components of the thioredoxin system.	Acrylamide	29-39	thioredoxin	Homo sapiens	218-229
31905027-2	2020	Coffee beverage is one of the most important sources of acrylamide, because the raw bean contains the reaction substrates and it is processed at very high temperature during roasting.	Acrylamide	56-66	brain expressed associated with NEDD4 1	Homo sapiens	84-88
31918398-2	2020	In this study, a new class of thieno[3,2-d]pyrimidines harboring acrylamide pharmacophore were synthesized as potent covalent JAK3 inhibitors (IC50 &lt; 10 nM).	Acrylamide	65-75	Janus kinase 3	Homo sapiens	126-130
31822471-12	2019	Suppression of CK by acrylamide in XtiSCs led to breakdown of membrane-bound beta-catenin but not F-actin and beta-tubulin or cell adhesion proteins (Focal adhesion kinase and integrin beta1).	Acrylamide	21-31	integrin subunit beta 1	Xenopus tropicalis	176-190
31223032-7	2019	In HCE-T cells, the amount of DNA fragments was statistically significantly increased in acridine orange-, ethidium bromide-, hydrogen peroxide-, 4-NQO- and MMS-treated cells but not in paraquat- or acrylamide-treated cells.	Acrylamide	199-209	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	3-6
31294559-0	2019	Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes.	Acrylamide	21-31	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	127-132
31647937-4	2020	ACR induced abnormal gait and elevated serum levels of proinflammatory cytokines (IL-6 and TNF-alpha), brain and spinal cord MDA levels and decreased brain and spinal cord GSH levels.	Acrylamide	0-3	interleukin 6	Rattus norvegicus	82-86
31647937-4	2020	ACR induced abnormal gait and elevated serum levels of proinflammatory cytokines (IL-6 and TNF-alpha), brain and spinal cord MDA levels and decreased brain and spinal cord GSH levels.	Acrylamide	0-3	tumor necrosis factor	Rattus norvegicus	91-100
31775334-2	2019	Current research in this area is focused on the synthesis of poly(acrylamide) grafted Cell@Fe3O4 nanocomposites via oxidative free radical copolymerization of the acrylamide monomer and its application for the removal of Pb(II).	Acrylamide	61-77	submaxillary gland androgen regulated protein 3B	Homo sapiens	221-227
31775334-2	2019	Current research in this area is focused on the synthesis of poly(acrylamide) grafted Cell@Fe3O4 nanocomposites via oxidative free radical copolymerization of the acrylamide monomer and its application for the removal of Pb(II).	Acrylamide	66-76	submaxillary gland androgen regulated protein 3B	Homo sapiens	221-227
31171159-4	2019	The imprinted cocktail polymer ((MIP(PSA, Myo)-SPE)) was synthesized at the SPE surface using acrylamide as monomer, N,N"-methylenebisacrylamide as a crosslinker, and PSA and Myo as the templates, respectively.	Acrylamide	94-104	myoglobin	Homo sapiens	42-45
31747445-7	2019	Given the prevalence of null GST polymorphisms in the human population (approximately 50% for GSTM1 and 20-50% for GSTT1), a substantial portion of the population may also have impaired acrylamide metabolism.	Acrylamide	186-196	hematopoietic prostaglandin D synthase	Mus musculus	29-32
31550155-4	2019	We found that such new agents can effectively and rapidly form a covalent adduct with XIAP-BIR3 in vitro and in cell, approaching the rate of reaction, cellular permeability, and stability that are similar to what attained by acrylamides when targeting Cys residues.	Acrylamide	226-237	X-linked inhibitor of apoptosis	Homo sapiens	86-90
31569795-5	2019	Treatments with withaferin A or acrylamide show that cell motility can be modulated by regulating vimentin assembly.	Acrylamide	32-42	vimentin	Homo sapiens	98-106
31294559-0	2019	Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes.	Acrylamide	21-31	cryptochrome circadian regulator 1	Homo sapiens	137-141
31294559-5	2019	Acrylamide significantly triggered disorders of circadian genes transcription and protein expressions including Bmal1 and Cry 1 in primary hepatocytes, which were prevented by resveratrol pretreatment.	Acrylamide	0-10	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	112-117
31294559-5	2019	Acrylamide significantly triggered disorders of circadian genes transcription and protein expressions including Bmal1 and Cry 1 in primary hepatocytes, which were prevented by resveratrol pretreatment.	Acrylamide	0-10	cryptochrome circadian regulator 1	Homo sapiens	122-127
31294559-6	2019	Moreover, we found that the beneficial effects of resveratrol on stimulating Nrf2/NQO-1 pathway and mitochondrial respiration complex expressions in acrylamide-treated cells were Bmal1-dependent.	Acrylamide	149-159	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	179-184
30516376-0	2018	Correction to Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent Pathway.	Acrylamide	14-24	activating transcription factor 3	Homo sapiens	87-91
31074891-9	2019	Dimeric quaternary models were further culled using acrylamide quenching data of SIKE"s single tryptophan that showed a single, protected environment.	Acrylamide	52-62	suppressor of IKBKE 1	Homo sapiens	81-85
31349581-2	2019	Two monomers, namely methacrylic acid (MAA) and acrylamide (AA), were used in the preparation of MIP receptors.	Acrylamide	48-58	major intrinsic protein of lens fiber	Homo sapiens	97-100
28963442-0	2019	Acrylamide induces HepG2 cell proliferation through upregulation of miR-21 expression.	Acrylamide	0-10	microRNA 21	Homo sapiens	68-74
28963442-3	2019	The present study aimed to investigate the potential mechanism of human hepatocarcinoma HepG2 cell proliferation induced by acrylamide and to explore the antagonistic effects of a natural polyphenol curcumin against acrylamide via miR-21.	Acrylamide	216-226	microRNA 21	Homo sapiens	231-237
28963442-4	2019	The results indicated that acrylamide (&lt;=100 mumol/L) significantly increased HepG2 cell proliferation and miR-21 expression.	Acrylamide	27-37	microRNA 21	Homo sapiens	110-116
28963442-5	2019	In addition, acrylamide reduced the PTEN expression in protein level, while induced the expressions of p-AKT, EGFR and cyclin D1.	Acrylamide	13-23	phosphatase and tensin homolog	Homo sapiens	36-40
28963442-5	2019	In addition, acrylamide reduced the PTEN expression in protein level, while induced the expressions of p-AKT, EGFR and cyclin D1.	Acrylamide	13-23	AKT serine/threonine kinase 1	Homo sapiens	105-108
28963442-5	2019	In addition, acrylamide reduced the PTEN expression in protein level, while induced the expressions of p-AKT, EGFR and cyclin D1.	Acrylamide	13-23	epidermal growth factor receptor	Homo sapiens	110-114
28963442-5	2019	In addition, acrylamide reduced the PTEN expression in protein level, while induced the expressions of p-AKT, EGFR and cyclin D1.	Acrylamide	13-23	cyclin D1	Homo sapiens	119-128
28963442-7	2019	In addition, curcumin effectively reduced acrylamide-induced HepG2 cell proliferation and induced apoptosis through the expression of miR-21.	Acrylamide	42-52	microRNA 21	Homo sapiens	134-140
28963442-8	2019	In conclusion, the results showed that acrylamide increased HepG2 cell proliferation via upregulating miR-21 expression, which may be a new target for the treatment and prevention of cancer.	Acrylamide	39-49	microRNA 21	Homo sapiens	102-108
30594716-7	2019	Expression levels of most placental key genes such as Esx1, Hand1, and Hand2 mRNA dramatically decreased in acrylamide-treated placentas.	Acrylamide	108-118	extraembryonic, spermatogenesis, homeobox 1	Mus musculus	54-58
30594716-7	2019	Expression levels of most placental key genes such as Esx1, Hand1, and Hand2 mRNA dramatically decreased in acrylamide-treated placentas.	Acrylamide	108-118	heart and neural crest derivatives expressed 1	Mus musculus	60-65
30594716-7	2019	Expression levels of most placental key genes such as Esx1, Hand1, and Hand2 mRNA dramatically decreased in acrylamide-treated placentas.	Acrylamide	108-118	heart and neural crest derivatives expressed 2	Mus musculus	71-76
30594716-8	2019	Furthermore, acrylamide treatment inhibited proliferation and induced apoptosis of placentas, as shown by decreased Ki67-positive cells and Bcl-2 protein, and increased the expression of Bax, cleaved-caspase-3, and cleaved-caspase-8 proteins.	Acrylamide	13-23	antigen identified by monoclonal antibody Ki 67	Mus musculus	116-120
30594716-8	2019	Furthermore, acrylamide treatment inhibited proliferation and induced apoptosis of placentas, as shown by decreased Ki67-positive cells and Bcl-2 protein, and increased the expression of Bax, cleaved-caspase-3, and cleaved-caspase-8 proteins.	Acrylamide	13-23	B cell leukemia/lymphoma 2	Mus musculus	140-145
30594716-8	2019	Furthermore, acrylamide treatment inhibited proliferation and induced apoptosis of placentas, as shown by decreased Ki67-positive cells and Bcl-2 protein, and increased the expression of Bax, cleaved-caspase-3, and cleaved-caspase-8 proteins.	Acrylamide	13-23	BCL2-associated X protein	Mus musculus	187-190
30594716-8	2019	Furthermore, acrylamide treatment inhibited proliferation and induced apoptosis of placentas, as shown by decreased Ki67-positive cells and Bcl-2 protein, and increased the expression of Bax, cleaved-caspase-3, and cleaved-caspase-8 proteins.	Acrylamide	13-23	caspase 8	Mus musculus	223-232
30639288-7	2019	The partition coefficient (Kp) obtained indicated a Psd2 partition preference for this vesicles, confirmed by quenching assays using acrylamide and 5/16-doxyl-stearic acid.	Acrylamide	133-143	pleckstrin and Sec7 domain containing 2	Homo sapiens	52-56
30859246-0	2019	Rapid Analysis of Acrylamide in Tap and Well Water Samples by Solvent Terminated Dispersive Liquid-Liquid Microextraction Followed by GC-FID.	Acrylamide	18-28	nuclear RNA export factor 1	Homo sapiens	32-35
30859246-1	2019	A fast, green and low cost method for analysis of acrylamide in tap and well water has been presented for the first time using solvent terminated-dispersive liquid liquid microextraction (ST-DLLME) with a simple equipment which does not need centrifugation step followed by GC-FID.	Acrylamide	50-60	nuclear RNA export factor 1	Homo sapiens	64-67
29445914-0	2019	Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk.	Acrylamide	28-38	estrogen receptor 1	Homo sapiens	71-88
29445914-1	2019	PURPOSE: The association between dietary acrylamide intake and estrogen receptor-positive (ER+) breast cancer risk in epidemiological studies is inconsistent.	Acrylamide	41-51	estrogen receptor 1	Homo sapiens	63-80
29445914-1	2019	PURPOSE: The association between dietary acrylamide intake and estrogen receptor-positive (ER+) breast cancer risk in epidemiological studies is inconsistent.	Acrylamide	41-51	epiregulin	Homo sapiens	91-93
29445914-2	2019	By analyzing gene-acrylamide interactions for ER+ breast cancer risk, we aimed to clarify the role of acrylamide intake in ER+ breast cancer etiology.	Acrylamide	18-28	epiregulin	Homo sapiens	46-48
29445914-2	2019	By analyzing gene-acrylamide interactions for ER+ breast cancer risk, we aimed to clarify the role of acrylamide intake in ER+ breast cancer etiology.	Acrylamide	102-112	epiregulin	Homo sapiens	123-125
29445914-8	2019	RESULTS: Unexpectedly, there was a statistically non-significant inverse association between acrylamide and ER+ breast cancer risk among all women but with no clear dose-response relationship, and no association among never smokers.	Acrylamide	93-103	epiregulin	Homo sapiens	108-110
29445914-9	2019	Among the results for 57 SNPs and 2 gene deletions, rs1056827 in CYP1B1, rs2959008 and rs7173655 in CYP11A1, the GSTT1 gene deletion, and rs1052133 in hOGG1 showed a statistically significant interaction with acrylamide intake for ER+ breast cancer risk.	Acrylamide	209-219	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	100-107
29445914-11	2019	If anything, acrylamide was associated with a decreased ER+ breast cancer risk.	Acrylamide	13-23	epiregulin	Homo sapiens	56-58
29445914-12	2019	The interaction with SNPs in CYP1B1 and CYP11A1 suggests that acrylamide may influence ER+ breast cancer risk through sex hormone pathways.	Acrylamide	62-72	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	29-35
29445914-12	2019	The interaction with SNPs in CYP1B1 and CYP11A1 suggests that acrylamide may influence ER+ breast cancer risk through sex hormone pathways.	Acrylamide	62-72	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	40-47
29445914-12	2019	The interaction with SNPs in CYP1B1 and CYP11A1 suggests that acrylamide may influence ER+ breast cancer risk through sex hormone pathways.	Acrylamide	62-72	epiregulin	Homo sapiens	87-89
30653966-9	2019	Furthermore, when cells were cultured on fibronectin-coated acrylamide substrates of 8 and 50 kPa and then wounded, there was an injury-induced phosphorylation of Y1065 and substrate dependent changes in the number and size of vinculin containing focal adhesions.	Acrylamide	60-70	fibronectin 1	Homo sapiens	41-52
30653966-9	2019	Furthermore, when cells were cultured on fibronectin-coated acrylamide substrates of 8 and 50 kPa and then wounded, there was an injury-induced phosphorylation of Y1065 and substrate dependent changes in the number and size of vinculin containing focal adhesions.	Acrylamide	60-70	vinculin	Homo sapiens	227-235
30735370-1	2019	Using reported glutathione S-transferase omega 1 (GSTO1-1) cocrystal structures, we designed and synthesized acrylamide-containing compounds that covalently bind to Cys32 on the catalytic site.	Acrylamide	109-119	glutathione S-transferase omega 1	Homo sapiens	15-48
30735370-1	2019	Using reported glutathione S-transferase omega 1 (GSTO1-1) cocrystal structures, we designed and synthesized acrylamide-containing compounds that covalently bind to Cys32 on the catalytic site.	Acrylamide	109-119	glutathione S-transferase omega 1	Homo sapiens	50-57
30442651-1	2019	Acalabrutinib is a targeted, covalent inhibitor of Bruton tyrosine kinase (BTK) with a unique 2-butynamide warhead that has relatively lower reactivity than other marketed acrylamide covalent inhibitors.	Acrylamide	172-182	Bruton tyrosine kinase	Homo sapiens	75-78
30472599-1	2019	Second- and third-generation inhibitors of EGFR possess an acrylamide group which alkylates Cys797, allowing to overcome resistance due to insurgence of T790M mutation.	Acrylamide	59-69	epidermal growth factor receptor	Homo sapiens	43-47
30426904-0	2019	Design, Synthesis and Evaluation of Novel 3/4-((Substituted benzamidophenoxy) methyl)-N-hydroxybenzamides/propenamides as Histone Deacetylase Inhibitors and Antitumor Agents.	Acrylamide	106-118	histone deacetylase 9	Homo sapiens	122-141
31264935-8	2019	Similarly, SOD and GPx demonstrated decreased activities 3 h after exposure to ACR, followed by increased activities 48 h after exposure to ACR.	Acrylamide	79-82	peroxiredoxin 6 pseudogene 2	Mus musculus	19-22
31264935-8	2019	Similarly, SOD and GPx demonstrated decreased activities 3 h after exposure to ACR, followed by increased activities 48 h after exposure to ACR.	Acrylamide	140-143	peroxiredoxin 6 pseudogene 2	Mus musculus	19-22
31264935-9	2019	CAT activity was significantly increased 24 and 48 h after exposure to ACR.	Acrylamide	71-74	catalase	Mus musculus	0-3
30028969-0	2018	Schwann cells protect against CaMKII- and PKA-dependent Acrylamide-induced Synapsin I phosphorylation.	Acrylamide	56-66	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	30-36
30028969-0	2018	Schwann cells protect against CaMKII- and PKA-dependent Acrylamide-induced Synapsin I phosphorylation.	Acrylamide	56-66	synapsin I	Homo sapiens	75-85
30028969-1	2018	OBJECTIVES: To explore the effects of Acrylamide (ACR), as well as the influence of Schwann cells (SCs), on the signal transduction pathway and phosphorylation of Synapsin I in a Human neuroblastoma cell line (NB-1).	Acrylamide	38-48	synapsin I	Homo sapiens	163-173
31251477-7	2019	The native acrylamide gel data showed that F51S tended to prevent polymerization of A1AT.	Acrylamide	11-21	serpin family A member 1	Homo sapiens	84-88
31150581-0	2019	Toward Rational Design of Selective Molecularly Imprinted Polymers (MIPs) for Proteins: Computational and Experimental Studies of Acrylamide Based Polymers for Myoglobin.	Acrylamide	130-140	myoglobin	Homo sapiens	160-169
31150581-7	2019	CD spectroscopy was used to determine monomer effects on myoglobin secondary structure, with all monomers except the smallest monomer (acrylamide) causing significant changes.	Acrylamide	135-145	myoglobin	Homo sapiens	57-66
31109687-13	2019	Annexin V-labelled apoptotic cells and caspase 3/7 activity were higher than untreated cells in acrylamide-treated cells.	Acrylamide	96-106	annexin A5	Homo sapiens	0-9
31109687-13	2019	Annexin V-labelled apoptotic cells and caspase 3/7 activity were higher than untreated cells in acrylamide-treated cells.	Acrylamide	96-106	caspase 3	Homo sapiens	39-48
31109687-14	2019	Immunocytochemical examination revealed a marked decrease in Bcl-2, an increase in Bax and Nrf-2 protein staining upon acrylamide treatment.	Acrylamide	119-129	BCL2 associated X, apoptosis regulator	Homo sapiens	83-86
31109687-14	2019	Immunocytochemical examination revealed a marked decrease in Bcl-2, an increase in Bax and Nrf-2 protein staining upon acrylamide treatment.	Acrylamide	119-129	NFE2 like bZIP transcription factor 2	Homo sapiens	91-96
31104099-1	2019	L-asparaginase is an enzyme produced by microorganisms, plants, and animals, which is used clinically for the treatment for acute lymphoblastic leukemia (ALL) and, in the food industry, to control acrylamide formation in baked foods.	Acrylamide	197-207	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
31073625-6	2019	The results showed that 5-week exposure to acrylamide induced inflammatory responses in the cerebral cortex, evident by upregulated mRNA and protein expression of pro-inflammatory cytokines IL-1beta, IL-6, and IL-18.	Acrylamide	43-53	interleukin 1 alpha	Rattus norvegicus	190-198
31073625-6	2019	The results showed that 5-week exposure to acrylamide induced inflammatory responses in the cerebral cortex, evident by upregulated mRNA and protein expression of pro-inflammatory cytokines IL-1beta, IL-6, and IL-18.	Acrylamide	43-53	interleukin 6	Rattus norvegicus	200-204
31073625-6	2019	The results showed that 5-week exposure to acrylamide induced inflammatory responses in the cerebral cortex, evident by upregulated mRNA and protein expression of pro-inflammatory cytokines IL-1beta, IL-6, and IL-18.	Acrylamide	43-53	interleukin 18	Rattus norvegicus	210-215
31073625-7	2019	Acrylamide also induced activation of microglia, indicated by increased expression of microglial markers, CD11b and CD40, and increased CD11b/c-positive microglial area and microglial process length.	Acrylamide	0-10	integrin subunit alpha M	Rattus norvegicus	106-111
31073625-7	2019	Acrylamide also induced activation of microglia, indicated by increased expression of microglial markers, CD11b and CD40, and increased CD11b/c-positive microglial area and microglial process length.	Acrylamide	0-10	integrin subunit alpha M	Rattus norvegicus	136-141
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	NLR family, pyrin domain containing 3	Rattus norvegicus	100-105
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	NLR family, pyrin domain containing 3	Rattus norvegicus	166-171
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	caspase 1	Rattus norvegicus	173-182
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	PYD and CARD domain containing	Rattus norvegicus	188-191
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	NLR family, pyrin domain containing 3	Rattus norvegicus	166-171
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	NLR family, pyrin domain containing 3	Rattus norvegicus	166-171
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	caspase 1	Rattus norvegicus	331-340
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	interleukin 1 alpha	Rattus norvegicus	342-350
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	13-23	interleukin 18	Rattus norvegicus	356-361
31073625-9	2019	Furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the NLRP3 inflammasome pathway, as evident by increased expression of NLRP3, caspase 1, and ASC in the rat cerebral cortex, and by the inhibitory effects of NLRP3 inflammasome inhibitor on the acrylamide-induced upregulation of NLRP3, caspase 1, IL-1beta, and IL-18 in BV-2 microglia.	Acrylamide	289-299	NLR family, pyrin domain containing 3	Rattus norvegicus	100-105
31159410-4	2019	The rheological measurements revealed that the viscoelasticity and stiffness of the P(AAc-co-Am)/PVA DN hydrogels increase as the acrylamide and Fe3+ concentrations increase.	Acrylamide	130-140	glycine-N-acyltransferase	Homo sapiens	86-89
30403487-4	2019	In this review, we summarize the latest developments in FGFR4 inhibitors, including the known pharmacophores, their binding mode, selectivity, and clinical implications, as well as the optimization strategy of introducing an acrylamide into a known pan-FGFR inhibitor targeting Cys552 of FGFR4 to provide selective covalent FGFR4 inhibitors.	Acrylamide	225-235	fibroblast growth factor receptor 4	Homo sapiens	56-61
30403487-4	2019	In this review, we summarize the latest developments in FGFR4 inhibitors, including the known pharmacophores, their binding mode, selectivity, and clinical implications, as well as the optimization strategy of introducing an acrylamide into a known pan-FGFR inhibitor targeting Cys552 of FGFR4 to provide selective covalent FGFR4 inhibitors.	Acrylamide	225-235	fibroblast growth factor receptor 4	Homo sapiens	56-60
30368882-0	2019	MAPKs and NF-kappaB-mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5Y.	Acrylamide	29-39	nuclear factor kappa B subunit 1	Homo sapiens	10-19
30368882-2	2019	In this study, the detrimental effects of ACR on the striatal dopaminergic neurons and the roles of mitogen-activated protein kinases (MAPKs) and nuclear factor kappaB (NF-kappaB) in ACR-induced neuronal apoptosis were investigated.	Acrylamide	183-186	nuclear factor kappa B subunit 1	Homo sapiens	169-178
30368882-6	2019	Specific inhibitors were used to explore the roles of MAPKs and NF-kappaB pathways in ACR-induced apoptosis in SH-SY5Y cells.	Acrylamide	86-89	nuclear factor kappa B subunit 1	Homo sapiens	64-73
30368882-7	2019	Pretreatment with JNK-specific inhibitors SP600125 markedly upregulated the reduced B-cell lymphoma 2 (Bcl-2) content and downregulated the increased Bcl-2-associated X protein (Bax) level and thereby eventually reduced the proportions of early and late apoptotic cells induced by ACR, while p38 suppression by SB202190 only reversed the decrease in Bcl-2 expression.	Acrylamide	281-284	mitogen-activated protein kinase 8	Homo sapiens	18-21
30368882-7	2019	Pretreatment with JNK-specific inhibitors SP600125 markedly upregulated the reduced B-cell lymphoma 2 (Bcl-2) content and downregulated the increased Bcl-2-associated X protein (Bax) level and thereby eventually reduced the proportions of early and late apoptotic cells induced by ACR, while p38 suppression by SB202190 only reversed the decrease in Bcl-2 expression.	Acrylamide	281-284	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181
30368882-8	2019	Inhibition of NF-kappaB by BAY 11-7082 markedly upregulated Bax level and decreased Bcl-2 expression, and eventually increasing the proportions of neuronal apoptosis compared with that in ACR alone.	Acrylamide	188-191	nuclear factor kappa B subunit 1	Homo sapiens	14-23
30368882-9	2019	These results suggested that JNK contributed to ACR-induced apoptosis, while NF-kappaB acted as a protective regulator in response to ACR-induced neuropathy.	Acrylamide	134-137	nuclear factor kappa B subunit 1	Homo sapiens	77-86
30513368-3	2019	The recombinant P. pastoris was inoculated in to BMMY culture medium, incubation with 5 mul/ml absolute methanol for 72 h at 30  C. The TC-1 peptide was concentrated with nickel affinity chromatography and electrophoresis on 16% acrylamide gels.	Acrylamide	229-239	pro-platelet basic protein	Homo sapiens	136-140
30236713-0	2019	An electrochemical biosensor based on hemoglobin-oligonucleotides-modified electrode for detection of acrylamide in potato fries.	Acrylamide	102-112	hemoglobin	Solanum tuberosum	38-48
30236713-2	2019	In this study, an electrochemical sensor for detection of acrylamide using double stranded DNA (dsDNA)/Hemoglobin (Hb)-modified screen printed gold electrode (SPGE) was designed.	Acrylamide	58-68	hemoglobin	Solanum tuberosum	103-113
30516376-0	2018	Correction to Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent Pathway.	Acrylamide	14-24	mitogen-activated protein kinase 14	Homo sapiens	98-101
30516376-0	2018	Correction to Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent Pathway.	Acrylamide	14-24	mitogen-activated protein kinase 8	Homo sapiens	102-105
30196695-0	2018	Acrylamide Defects the Expression Pattern of the Circadian Clock and Mitochondrial Dynamics in C57BL/6J Mice Liver and HepG2 Cells.	Acrylamide	0-10	circadian locomotor output cycles kaput	Mus musculus	59-64
29196268-6	2018	We present a promising histological method based on optical 3D imaging combined with a tissue clearing method, Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging compatible Tissue hYdrogel (CLARITY), adapted for hMRI validation.	Acrylamide	133-143	cell cycle regulator of NHEJ	Homo sapiens	219-223
30392349-2	2018	We identified a noncatalytic cysteine (Cys481 in KDM5A) near the active sites of KDM5 histone H3 lysine 4 demethylases, which is absent in other histone demethylase families, that could be explored for interaction with the cysteine-reactive electrophile acrylamide.	Acrylamide	254-264	lysine demethylase 5A	Homo sapiens	49-54
30655941-0	2019	Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.	Acrylamide	0-10	epidermal growth factor receptor	Homo sapiens	89-93
30222996-0	2018	Changes in VIP-, SP- and CGRP- like immunoreactivity in intramural neurons within the pig stomach following supplementation with low and high doses of acrylamide.	Acrylamide	151-161	vasoactive intestinal peptide	Homo sapiens	11-14
30222996-0	2018	Changes in VIP-, SP- and CGRP- like immunoreactivity in intramural neurons within the pig stomach following supplementation with low and high doses of acrylamide.	Acrylamide	151-161	calcitonin related polypeptide alpha	Homo sapiens	25-29
30222996-3	2018	The aim of this experiment was to determine the influence of acrylamide, administered at doses equivalent to the human tolerable daily intake (TDI, 0.5 mug/kg b.w./day) and ten times higher than the TDI (5 mug/kg b.w./day), on the distribution of vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene related peptide (CGRP) in intramural neurons of the domestic pig stomach.	Acrylamide	61-71	vasoactive intestinal peptide	Homo sapiens	278-281
30222996-3	2018	The aim of this experiment was to determine the influence of acrylamide, administered at doses equivalent to the human tolerable daily intake (TDI, 0.5 mug/kg b.w./day) and ten times higher than the TDI (5 mug/kg b.w./day), on the distribution of vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene related peptide (CGRP) in intramural neurons of the domestic pig stomach.	Acrylamide	61-71	calcitonin related polypeptide alpha	Homo sapiens	339-343
30222996-4	2018	Using double immunofluorescent labelling we revealed that the ENS neurons underwent adaptive changes in response to the supplementation of acrylamide, which manifested themselves as increased expression of VIP, SP and CGRP, both in intramural neurons and by an increase in the nerve density in submucous and muscular layers in the porcine stomach.	Acrylamide	139-149	vasoactive intestinal peptide	Homo sapiens	206-209
30222996-4	2018	Using double immunofluorescent labelling we revealed that the ENS neurons underwent adaptive changes in response to the supplementation of acrylamide, which manifested themselves as increased expression of VIP, SP and CGRP, both in intramural neurons and by an increase in the nerve density in submucous and muscular layers in the porcine stomach.	Acrylamide	139-149	calcitonin related polypeptide alpha	Homo sapiens	218-222
30121557-2	2018	In this synthesis process of T-MIR, 2-acrylamide-2- methylpropanesulfonic acid (AMPS) and acrylamide (AAm) were coupled as zipper-like thermo-responsive monomers, resorcinol, and melamine as hydrophilic monomers, formaldehyde as a cross-linker, and berberine chloride (BerbC) as the template.	Acrylamide	38-48	membrane associated ring-CH-type finger 8	Homo sapiens	31-34
30121557-2	2018	In this synthesis process of T-MIR, 2-acrylamide-2- methylpropanesulfonic acid (AMPS) and acrylamide (AAm) were coupled as zipper-like thermo-responsive monomers, resorcinol, and melamine as hydrophilic monomers, formaldehyde as a cross-linker, and berberine chloride (BerbC) as the template.	Acrylamide	102-105	membrane associated ring-CH-type finger 8	Homo sapiens	31-34
30092978-2	2018	Polyacrylamide grafted cellulose nanocrystal (CNC-g-PAM) was first synthesized by ceric salt initiated surface graft polymerization of acrylamide onto CNC, then incorporated into chemically crosslinked poly(acrylic acid) (PAA) networks to obtain dual-crosslinked CNC-g-PAM/PAA nanocomposite hydrogels.	Acrylamide	4-14	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	52-55
30092978-2	2018	Polyacrylamide grafted cellulose nanocrystal (CNC-g-PAM) was first synthesized by ceric salt initiated surface graft polymerization of acrylamide onto CNC, then incorporated into chemically crosslinked poly(acrylic acid) (PAA) networks to obtain dual-crosslinked CNC-g-PAM/PAA nanocomposite hydrogels.	Acrylamide	4-14	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	269-272
30196695-3	2018	The aim of this research is to investigate whether the circadian clock is involved in the toxicity mechanisms of acrylamide in mice liver.	Acrylamide	113-123	circadian locomotor output cycles kaput	Mus musculus	65-70
30196695-7	2018	Acrylamide blocked circadian protein expression via repressing the phosphorylation of AKT or inducing oxidative stress.	Acrylamide	0-10	thymoma viral proto-oncogene 1	Mus musculus	86-89
30196695-8	2018	Taken together, our work reveals acrylamide as a clock-repressing compound generated through the Maillard browning reaction in certain foods that may possess a toxic effect via circadian clock mechanisms.	Acrylamide	33-43	circadian locomotor output cycles kaput	Mus musculus	49-54
30196695-8	2018	Taken together, our work reveals acrylamide as a clock-repressing compound generated through the Maillard browning reaction in certain foods that may possess a toxic effect via circadian clock mechanisms.	Acrylamide	33-43	circadian locomotor output cycles kaput	Mus musculus	187-192
30229907-1	2018	3-Aminopropanamide (3-APA) is the direct precursor of acrylamide produced in the Maillard reaction between asparagine and reducing sugars.	Acrylamide	54-64	glutamyl aminopeptidase	Homo sapiens	22-25
29722103-2	2018	It is shown that by using sterically large, hydrophilic glycomonomers such as a lactose acrylamide with the charged azo initiator 4,4"-azobis(4-cyanovaleric acid), growing particles are stabilized enough to reproducibly produce well defined (PDi &lt;= 0.1) glycoparticles with diameters below 100 nm.	Acrylamide	88-98	peptidyl arginine deiminase 1	Homo sapiens	242-245
30229907-2	2018	In this research, we found that 3-APA could reduce acrylamide by the formation of adducts between acrylamide and 3-APA via Michael addition.	Acrylamide	51-61	glutamyl aminopeptidase	Homo sapiens	34-37
30229907-2	2018	In this research, we found that 3-APA could reduce acrylamide by the formation of adducts between acrylamide and 3-APA via Michael addition.	Acrylamide	51-61	glutamyl aminopeptidase	Homo sapiens	115-118
30229907-2	2018	In this research, we found that 3-APA could reduce acrylamide by the formation of adducts between acrylamide and 3-APA via Michael addition.	Acrylamide	98-108	glutamyl aminopeptidase	Homo sapiens	34-37
30229907-2	2018	In this research, we found that 3-APA could reduce acrylamide by the formation of adducts between acrylamide and 3-APA via Michael addition.	Acrylamide	98-108	glutamyl aminopeptidase	Homo sapiens	115-118
30229907-3	2018	The effects of temperature, heating duration and 3-APA/acrylamide ratio on the reduction of acrylamide were investigated.	Acrylamide	92-102	glutamyl aminopeptidase	Homo sapiens	51-54
30229907-4	2018	Addition of 3-APA to acrylamide at a molar ratio of 5:3 at 160  C for 20 min reduced acrylamide by up to 47.29%.	Acrylamide	21-31	glutamyl aminopeptidase	Homo sapiens	14-17
30229907-4	2018	Addition of 3-APA to acrylamide at a molar ratio of 5:3 at 160  C for 20 min reduced acrylamide by up to 47.29%.	Acrylamide	85-95	glutamyl aminopeptidase	Homo sapiens	14-17
30229907-7	2018	PRACTICAL APPLICATION: The current study reported 3-APA could reduce acrylamide through the Micheal addition reaction between 3-APA and acrylamide.	Acrylamide	69-79	glutamyl aminopeptidase	Homo sapiens	52-55
30229907-7	2018	PRACTICAL APPLICATION: The current study reported 3-APA could reduce acrylamide through the Micheal addition reaction between 3-APA and acrylamide.	Acrylamide	69-79	glutamyl aminopeptidase	Homo sapiens	128-131
30229907-7	2018	PRACTICAL APPLICATION: The current study reported 3-APA could reduce acrylamide through the Micheal addition reaction between 3-APA and acrylamide.	Acrylamide	136-146	glutamyl aminopeptidase	Homo sapiens	52-55
30229907-7	2018	PRACTICAL APPLICATION: The current study reported 3-APA could reduce acrylamide through the Micheal addition reaction between 3-APA and acrylamide.	Acrylamide	136-146	glutamyl aminopeptidase	Homo sapiens	128-131
29427883-4	2018	To synthesize the molecularly imprinted polymer, monomers of acrylamide and N,N"-methylenebis(acrylamide) were polymerized around the EGFR and VEGF templates, and to characterize the prepared biosensor, electrochemical impedance spectroscopy was used for analyses of surface changes in the engineered electrodes.	Acrylamide	61-71	epidermal growth factor receptor	Homo sapiens	134-138
29944933-0	2018	Acrylamide-induced alterations in the cocaine- and amphetamine-regulated peptide transcript (CART)-like immunoreactivity within the enteric nervous system of the porcine small intestines.	Acrylamide	0-10	CART prepropeptide	Sus scrofa	93-97
29944933-1	2018	The main goal of the present study was to determine the influence of low and high doses of acrylamide on CART-like immunoreactivity within the ENS of the porcine small intestines.	Acrylamide	91-101	CART prepropeptide	Sus scrofa	105-109
29944933-7	2018	Acrylamide intoxication resulted in a significant increase in expression of CART in the intramural neurons of the porcine small intestines, especially in myenteric plexuses.	Acrylamide	0-10	CART prepropeptide	Sus scrofa	76-80
31719782-0	2018	Glutathione S-transferase is a good biomarker in acrylamide induced neurotoxicity and genotoxicity.	Acrylamide	49-59	hematopoietic prostaglandin D synthase	Rattus norvegicus	0-25
29499278-6	2018	Acrylamide quenching of tryptophan fluorescence to probe Pgp conformational changes revealed that methadone- and loperamide-induced conformational changes were distinct.	Acrylamide	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	57-60
29734925-6	2018	Then, we treated cells with the IC50 dose of acrylamide for 24 h and determined whether the dominant death mode of NIH/3T3 cells was apoptosis or necrosis by annexin V and caspase 3/7 assays.	Acrylamide	45-55	annexin A5	Mus musculus	158-167
29734925-6	2018	Then, we treated cells with the IC50 dose of acrylamide for 24 h and determined whether the dominant death mode of NIH/3T3 cells was apoptosis or necrosis by annexin V and caspase 3/7 assays.	Acrylamide	45-55	caspase 3	Mus musculus	172-181
29734925-10	2018	Also, caspase 3/7 activities of the acrylamide-treated NIH/3T3 cells were three times greater than those of the untreated NIH/3T3 cells.	Acrylamide	36-46	caspase 3	Mus musculus	6-15
29748789-0	2018	The polymorphism rs2480258 within CYP2E1 is associated with different rates of acrylamide metabolism in vivo in humans.	Acrylamide	79-89	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	34-40
29748789-2	2018	CYP2E1 is the most important enzyme in the metabolism of acrylamide (AA) by operating its oxidation into glycidamide (GA).	Acrylamide	57-67	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
29853340-1	2018	In the present study, a new class of compounds containing pyrido[3,4-d]pyrimidine scaffold with an acrylamide moiety was designed as irreversible EGFR-TKIs to overcome acquired EGFR-T790M resistance.	Acrylamide	99-109	epidermal growth factor receptor	Homo sapiens	146-150
29853340-1	2018	In the present study, a new class of compounds containing pyrido[3,4-d]pyrimidine scaffold with an acrylamide moiety was designed as irreversible EGFR-TKIs to overcome acquired EGFR-T790M resistance.	Acrylamide	99-109	epidermal growth factor receptor	Homo sapiens	177-181
29427883-4	2018	To synthesize the molecularly imprinted polymer, monomers of acrylamide and N,N"-methylenebis(acrylamide) were polymerized around the EGFR and VEGF templates, and to characterize the prepared biosensor, electrochemical impedance spectroscopy was used for analyses of surface changes in the engineered electrodes.	Acrylamide	61-71	vascular endothelial growth factor A	Homo sapiens	143-147
29427883-4	2018	To synthesize the molecularly imprinted polymer, monomers of acrylamide and N,N"-methylenebis(acrylamide) were polymerized around the EGFR and VEGF templates, and to characterize the prepared biosensor, electrochemical impedance spectroscopy was used for analyses of surface changes in the engineered electrodes.	Acrylamide	94-104	epidermal growth factor receptor	Homo sapiens	134-138
29427883-4	2018	To synthesize the molecularly imprinted polymer, monomers of acrylamide and N,N"-methylenebis(acrylamide) were polymerized around the EGFR and VEGF templates, and to characterize the prepared biosensor, electrochemical impedance spectroscopy was used for analyses of surface changes in the engineered electrodes.	Acrylamide	94-104	vascular endothelial growth factor A	Homo sapiens	143-147
29697282-7	2018	With respect to acrylamide-gene interactions, only rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs2301241 in thioredoxin (TXN) showed a nominally statistically significant multiplicative interaction with acrylamide intake for advanced prostate cancer risk.	Acrylamide	16-26	NAD(P)H quinone dehydrogenase 1	Homo sapiens	64-95
28906145-1	2018	This study was designed to evaluate the effect of rutin on PI3K/AKT-signalling in case of acrylamide or gamma-radiation-induced neurotoxicity.	Acrylamide	90-100	AKT serine/threonine kinase 1	Homo sapiens	64-67
28906145-6	2018	It could be concluded that rutin provides protection effect against acrylamide or gamma-radiation-induced neurotoxicity via activation of the PI3K/AKT/GSK-3beta/NRF-2-pathway by altering the phosphorylation state through its ability to scavenge free radicals generation, modulating gene expression and its anti-inflammatory effects.	Acrylamide	68-78	AKT serine/threonine kinase 1	Homo sapiens	147-150
28906145-6	2018	It could be concluded that rutin provides protection effect against acrylamide or gamma-radiation-induced neurotoxicity via activation of the PI3K/AKT/GSK-3beta/NRF-2-pathway by altering the phosphorylation state through its ability to scavenge free radicals generation, modulating gene expression and its anti-inflammatory effects.	Acrylamide	68-78	glycogen synthase kinase 3 beta	Homo sapiens	151-160
29475067-0	2018	Transcriptional profiling of male CD-1 mouse lungs and Harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors.	Acrylamide	121-131	CD1 antigen complex	Mus musculus	34-38
29426002-0	2018	Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-kappaB pathways regulated by MAPKs.	Acrylamide	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
28569085-8	2018	RESULTS: According to the MTT assay results, A549 cell viability decreases proportionally with increasing acrylamide concentrations and IC50 for A549 was 4.6 mM for 24 h. Annexin-V FITC/PI assay results indicated that acrylamide induces apoptosis in 64% of the A549 cells.	Acrylamide	106-116	annexin A5	Homo sapiens	171-180
28569085-8	2018	RESULTS: According to the MTT assay results, A549 cell viability decreases proportionally with increasing acrylamide concentrations and IC50 for A549 was 4.6 mM for 24 h. Annexin-V FITC/PI assay results indicated that acrylamide induces apoptosis in 64% of the A549 cells.	Acrylamide	218-228	annexin A5	Homo sapiens	171-180
29697282-7	2018	With respect to acrylamide-gene interactions, only rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs2301241 in thioredoxin (TXN) showed a nominally statistically significant multiplicative interaction with acrylamide intake for advanced prostate cancer risk.	Acrylamide	215-225	thioredoxin	Homo sapiens	120-131
29524570-4	2018	Results showed that after administration of 30 mg/kg ACR, decreased body weight, attenuated neurobehavioural function, injury of motor neuron, increased protein levels of m-calpain and beta-tubulin, suppressed MAP2 protein level, and no significant changes of mu-calpain and alpha-tubulin protein levels were observed compared with the control group rats.	Acrylamide	53-56	calpain 2	Rattus norvegicus	171-180
29524570-4	2018	Results showed that after administration of 30 mg/kg ACR, decreased body weight, attenuated neurobehavioural function, injury of motor neuron, increased protein levels of m-calpain and beta-tubulin, suppressed MAP2 protein level, and no significant changes of mu-calpain and alpha-tubulin protein levels were observed compared with the control group rats.	Acrylamide	53-56	microtubule-associated protein 2	Rattus norvegicus	210-214
29524570-7	2018	The calpain"s overactivation causes the degrading of MAP2 and eventually leads to the destruction of microtubules (MTs), which may be one of the mechanisms of cytoskeletal damage induced by ACR.	Acrylamide	190-193	microtubule-associated protein 2	Rattus norvegicus	53-57
29584430-2	2018	Specific inhibition of the BimBH3-Bcl2A1 protein-protein interaction was obtained in vitro and in cancer cells by shortening the peptide to 14 residues, inserting two cyclization constraints to stabilize a water-stable alpha-helix, and incorporating an N-terminal acrylamide electrophile for selective covalent bonding to Bcl2A1.	Acrylamide	264-274	BCL2 related protein A1	Homo sapiens	34-40
29636310-9	2018	RESULTS: Acrylamide reduced body (p&lt;0.01) and testis weights (p&lt;0.05), seminiferous tubule diameter (p&lt;0.001) and proliferating cell nuclear antigen expression (p&lt;0.05), while it increased bax protein expression (p&lt;0.01) and the percentage of seminiferous tubules that contain multinucleated giant cells (p&lt;0.001), but did not significantly change serum testosterone levels when compared to control.	Acrylamide	9-19	BCL2 associated X, apoptosis regulator	Rattus norvegicus	201-204
29636310-10	2018	L-cysteine administered with acrylamide decreased multinucleated giant cell number (p&lt;0.001) and reversed the reduced proliferating cell nuclear antigen positivity (p&lt;0.001), but did not restore other parameters compared with the acrylamide alone-treated group.	Acrylamide	29-39	proliferating cell nuclear antigen	Rattus norvegicus	121-155
28956625-0	2018	The influence of demographic, physical, behavioral, and dietary factors on hemoglobin adduct levels of acrylamide and glycidamide in the general U.S. population.	Acrylamide	103-113	hemoglobin	Solanum tuberosum	75-85
29482151-0	2018	New acrylamide-substituted quinazoline derivatives with enhanced potency for the treatment of EGFR T790M-mutant non-small-cell lung cancers.	Acrylamide	4-14	epidermal growth factor receptor	Homo sapiens	94-98
29482151-1	2018	A new class of acrylamide-substituted quinazoline derivatives with enhanced inhibitory activity against mutant EGFR T790M enzyme were synthesized.	Acrylamide	15-25	epidermal growth factor receptor	Homo sapiens	111-115
28956625-1	2018	PURPOSE: This study aims to better understand the individual characteristics and dietary factors that affect the relationship between estimated consumption of acrylamide and measured acrylamide hemoglobin adduct levels (HbAA) and glycidamide hemoglobin adduct levels (HbGA).	Acrylamide	183-193	hemoglobin	Solanum tuberosum	194-204
29576437-7	2018	Colonic EC cells expressed many different types of known and potential GPCR sensors of microbial metabolites including three receptors for SCFAs, i.e. FFAR2, OLF78, and OLF558 and receptors for aromatic acids, GPR35; secondary bile acids GPBAR1; and acyl-amides and lactate, GPR132.	Acrylamide	250-261	G protein-coupled receptor 166 pseudogene	Homo sapiens	71-75
29551216-7	2018	Moreover, L-asparaginase is also of interest in the food industry as it prevents acrylamide formation.	Acrylamide	81-91	asparaginase and isoaspartyl peptidase 1	Homo sapiens	10-24
28956625-1	2018	PURPOSE: This study aims to better understand the individual characteristics and dietary factors that affect the relationship between estimated consumption of acrylamide and measured acrylamide hemoglobin adduct levels (HbAA) and glycidamide hemoglobin adduct levels (HbGA).	Acrylamide	159-169	hemoglobin	Solanum tuberosum	194-204
28956625-1	2018	PURPOSE: This study aims to better understand the individual characteristics and dietary factors that affect the relationship between estimated consumption of acrylamide and measured acrylamide hemoglobin adduct levels (HbAA) and glycidamide hemoglobin adduct levels (HbGA).	Acrylamide	159-169	hemoglobin	Solanum tuberosum	242-252
29224921-2	2018	Acrylamide is metabolized by cytochrome P450 2E1 (CYP2E1) to glycidamide or by direct conjugation with glutathione.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	29-48
29732058-2	2018	It overcomes resistance to first-generation inhibitors by incorporating an acrylamide group which alkylates Cys797 of EGFR T790M.	Acrylamide	75-85	epidermal growth factor receptor	Homo sapiens	118-122
29732058-6	2018	The results show that Gln718 affects the conformational space of the EGFR-osimertinib complex, stabilizing a conformation of acrylamide which prevents reaction with Cys797.	Acrylamide	125-135	epidermal growth factor receptor	Homo sapiens	69-73
29224921-2	2018	Acrylamide is metabolized by cytochrome P450 2E1 (CYP2E1) to glycidamide or by direct conjugation with glutathione.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	50-56
29224921-5	2018	Immunohistochemically stained pancreatic sections revealed that acrylamide induced increase of iNOS and decrease of CYP2E1 protein expression, while expression of antioxidant enzymes was not significantly affected by acrylamide in islets of Langerhans.	Acrylamide	64-74	nitric oxide synthase 2	Rattus norvegicus	95-99
29224921-5	2018	Immunohistochemically stained pancreatic sections revealed that acrylamide induced increase of iNOS and decrease of CYP2E1 protein expression, while expression of antioxidant enzymes was not significantly affected by acrylamide in islets of Langerhans.	Acrylamide	64-74	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	116-122
29224921-7	2018	Increase in the GST activity, lipid peroxidation and nitrite level, and decrease in GSH content, CAT and SOD activities was observed in acrylamide-exposed Rin-5F cells.	Acrylamide	136-146	hematopoietic prostaglandin D synthase	Mus musculus	16-19
29224921-7	2018	Increase in the GST activity, lipid peroxidation and nitrite level, and decrease in GSH content, CAT and SOD activities was observed in acrylamide-exposed Rin-5F cells.	Acrylamide	136-146	catalase	Mus musculus	97-100
29224921-8	2018	Level of mRNA was increased for iNOS, SOD1 and SOD2, and decreased for GSTP1, Nrf2 and CYP2E1 in acrylamide-treated Rin-5F cells.	Acrylamide	97-107	nitric oxide synthase 2, inducible	Mus musculus	32-36
29224921-8	2018	Level of mRNA was increased for iNOS, SOD1 and SOD2, and decreased for GSTP1, Nrf2 and CYP2E1 in acrylamide-treated Rin-5F cells.	Acrylamide	97-107	superoxide dismutase 1, soluble	Mus musculus	38-42
29224921-8	2018	Level of mRNA was increased for iNOS, SOD1 and SOD2, and decreased for GSTP1, Nrf2 and CYP2E1 in acrylamide-treated Rin-5F cells.	Acrylamide	97-107	superoxide dismutase 2, mitochondrial	Mus musculus	47-51
29224921-8	2018	Level of mRNA was increased for iNOS, SOD1 and SOD2, and decreased for GSTP1, Nrf2 and CYP2E1 in acrylamide-treated Rin-5F cells.	Acrylamide	97-107	glutathione S-transferase, pi 1	Mus musculus	71-76
29224921-8	2018	Level of mRNA was increased for iNOS, SOD1 and SOD2, and decreased for GSTP1, Nrf2 and CYP2E1 in acrylamide-treated Rin-5F cells.	Acrylamide	97-107	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
29224921-8	2018	Level of mRNA was increased for iNOS, SOD1 and SOD2, and decreased for GSTP1, Nrf2 and CYP2E1 in acrylamide-treated Rin-5F cells.	Acrylamide	97-107	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	87-93
29223029-6	2018	Docking experiments on HDAC2 isozyme revealed some important features contributing to the inhibitory activity of synthesized compounds, especially for propenamide analogues.	Acrylamide	151-162	histone deacetylase 2	Homo sapiens	23-28
29926741-0	2018	Down-regulation of telomerase reverse transcriptase-related anti-apoptotic function in a rat model of acrylamide induced neurobehavioral deficits.	Acrylamide	102-112	telomerase reverse transcriptase	Rattus norvegicus	19-51
29443080-3	2018	It works by soaking the acrylamide or agarose DNA gel in a solution of 1x (equivalent to 2.0 microM) SYBR Green I (SG I) and 0.20 mM nitro blue tetrazolium that produces a purple precipitate of formazan when exposed to sunlight or specifically blue light.	Acrylamide	24-34	semenogelin 1	Homo sapiens	115-119
29607694-0	2018	Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner.	Acrylamide	19-29	AKT serine/threonine kinase 1	Rattus norvegicus	59-62
30354842-0	2018	Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3beta-dependent pathway.	Acrylamide	19-29	AKT serine/threonine kinase 1	Rattus norvegicus	79-82
30354842-0	2018	Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3beta-dependent pathway.	Acrylamide	19-29	glycogen synthase kinase 3 beta	Rattus norvegicus	83-91
29179065-0	2018	Reaction profiling of a set of acrylamide-based human tissue transglutaminase inhibitors.	Acrylamide	31-41	transglutaminase 2	Homo sapiens	54-77
30097947-3	2018	The acrylamide-pendant Zn2+-Phos-tag provides a phosphate affinity on simple SDS-PAGE gel for detection of mobility shift in phosphorylated proteins as compared to their nonphosphorylated forms.	Acrylamide	4-14	long intergenic non-protein coding RNA 1194	Homo sapiens	33-36
29580927-0	2018	Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain.	Acrylamide	0-10	brain-derived neurotrophic factor	Rattus norvegicus	77-81
30023574-0	2017	Agro Waste Utilization for Cost-Effective Production of l-Asparaginase by Pseudomonas plecoglossicida RS1 with Anticancer and Acrylamide Mitigation Potential.	Acrylamide	126-136	asparaginase and isoaspartyl peptidase 1	Homo sapiens	56-70
30023574-6	2017	Moreover, the purified l-asparaginase showed effective acrylamide mitigation in vitro, at 6 IU, and its effective degradation was also demonstrated by the effect on chemotactic index of Caenorhabditis elegans and the restoration of the cognitive abilities of C. elegans which was coexposed to acrylamide and l-asparaginase compared to that exposed to acrylamide alone.	Acrylamide	55-65	asparaginase and isoaspartyl peptidase 1	Homo sapiens	23-37
30023574-6	2017	Moreover, the purified l-asparaginase showed effective acrylamide mitigation in vitro, at 6 IU, and its effective degradation was also demonstrated by the effect on chemotactic index of Caenorhabditis elegans and the restoration of the cognitive abilities of C. elegans which was coexposed to acrylamide and l-asparaginase compared to that exposed to acrylamide alone.	Acrylamide	293-303	asparaginase and isoaspartyl peptidase 1	Homo sapiens	23-37
30023574-6	2017	Moreover, the purified l-asparaginase showed effective acrylamide mitigation in vitro, at 6 IU, and its effective degradation was also demonstrated by the effect on chemotactic index of Caenorhabditis elegans and the restoration of the cognitive abilities of C. elegans which was coexposed to acrylamide and l-asparaginase compared to that exposed to acrylamide alone.	Acrylamide	293-303	asparaginase and isoaspartyl peptidase 1	Homo sapiens	23-37
29136023-2	2017	The primary MRP which is detected at 60 C is important for Acrylamide content and color/aroma development in foods and also in the field of food biotechnology for controlling the extent of the Maillard reaction with temperature.	Acrylamide	59-69	ATP binding cassette subfamily C member 1	Homo sapiens	12-15
28892787-7	2017	On the contrary, it was also observed that AST, ALT, ALP, SOD and CAT activities and TOS and MDA levels increased as a result of acrylamide administration.	Acrylamide	129-139	PDZ and LIM domain 3	Rattus norvegicus	53-56
28139046-3	2017	Fluorescent hydrogel films (PVAm-g-N-CDs/PAM) were synthesized by interpenetration polymer network polymerization of PVAm-g-N-CDs and acrylamide (AM).	Acrylamide	134-144	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	41-44
29171430-11	2017	The number of neurons, as well as expression of growth associated protein 43 and synaptophysin, was reduced with increasing acrylamide dose in postnatal day 21 weaning rats.	Acrylamide	124-134	growth associated protein 43	Rattus norvegicus	48-76
29171430-11	2017	The number of neurons, as well as expression of growth associated protein 43 and synaptophysin, was reduced with increasing acrylamide dose in postnatal day 21 weaning rats.	Acrylamide	124-134	synaptophysin	Rattus norvegicus	81-94
28771761-4	2017	Group 3 (ACR) was injected IP with acrylamide (50 mg/kg BW/day).	Acrylamide	35-45	acrosin	Rattus norvegicus	9-12
27866376-2	2017	This reaction occurs when carbohydrate-rich foods are heated at temperatures above 120  C. Multiple potato varieties were transformed with potato genomic DNA that results in down-regulation of the expression of the asparagine synthetase-1 gene (Asn1), significantly reducing synthesis of free Asn, and consequently lowering the potential to form acrylamide during cooking.	Acrylamide	346-356	asparagine synthetase [glutamine-hydrolyzing]	Solanum tuberosum	215-238
28825640-2	2017	In this work, xylan-grafted-polyacrylamide (xylan-g-PAM) biopolymers were synthesized by the graft copolymerization of xylan with acrylamide, and their interaction with fibers was also investigated to improve waste newspaper pulp properties with or without cationic fiber fines.	Acrylamide	32-42	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	52-55
30108871-4	2017	In addition, the introduction of an acrylamide into a known FGFR scaffold identified a pan-FGFR inhibitor which reacted with both Cys552 and a second poorly conserved cysteine on the P-loop of FGFR4 at position 477 which is present in all four FGFR family members.	Acrylamide	36-46	fibroblast growth factor receptor 4	Homo sapiens	193-198
27501804-0	2017	Mitochondrion-Mediated Apoptosis Induced by Acrylamide is Regulated by a Balance Between Nrf2 Antioxidant and MAPK Signaling Pathways in PC12 Cells.	Acrylamide	44-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
28352901-4	2017	Through this coupled approach, we discovered a cysteine-reactive acrylamide DKM 3-30 that significantly impaired colorectal cancer cell pathogenicity through targeting C1101 on reticulon 4 (RTN4).	Acrylamide	65-75	reticulon 4	Homo sapiens	177-188
28352901-4	2017	Through this coupled approach, we discovered a cysteine-reactive acrylamide DKM 3-30 that significantly impaired colorectal cancer cell pathogenicity through targeting C1101 on reticulon 4 (RTN4).	Acrylamide	65-75	reticulon 4	Homo sapiens	190-194
28526328-0	2017	Acrylamide-induced neurotoxicity in primary astrocytes and microglia: Roles of the Nrf2-ARE and NF-kappaB pathways.	Acrylamide	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
28526328-0	2017	Acrylamide-induced neurotoxicity in primary astrocytes and microglia: Roles of the Nrf2-ARE and NF-kappaB pathways.	Acrylamide	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
29151073-5	2017	In our research we measured acrylamide"s influence on the acetylcholinesterase activity in hypothalamus, heart muscle, skeletal muscles of the thigh and smooth muscle of the small intestine (males, Swiss strain) in relation to the thiol groups and malondialdehyde concentration.	Acrylamide	28-38	acetylcholinesterase	Mus musculus	58-78
29151073-11	2017	The AChE activity evaluation in mice muscles and hypothalamus was very important because there are many evidences that acrylamide affects directly on the peripheral nerves.	Acrylamide	119-129	acetylcholinesterase	Mus musculus	4-8
28490250-0	2017	Effects of acrylamide graded doses on metallothioneins I and II induction and DNA fragmentation: Bochemical and histomorphological changes in the liver of adult rats.	Acrylamide	11-21	metallothionein 1	Rattus norvegicus	38-63
30970974-3	2017	In this work, a novel thermal-resistant and shear-stable amphoteric polyacrylamide (PASD), prepared from acrylamide (AM), sodium styrene sulfonate (SSS), and acryloxyethyl trimethylammonium chloride (DAC) monomers, was prepared by free-radical polymerization in high-salinity solution.	Acrylamide	72-82	arylacetamide deacetylase	Homo sapiens	200-203
28634368-1	2017	A fibrous adsorbent with amino-terminated hyperbranch structure (PP-AM-HBP-NH2) was prepared by grafting hyperbranched polyamine (HBP-NH2) onto the acrylamide-modified polypropylene (PP) fibers.	Acrylamide	148-158	heme binding protein 1	Homo sapiens	71-74
28634368-1	2017	A fibrous adsorbent with amino-terminated hyperbranch structure (PP-AM-HBP-NH2) was prepared by grafting hyperbranched polyamine (HBP-NH2) onto the acrylamide-modified polypropylene (PP) fibers.	Acrylamide	148-158	heme binding protein 1	Homo sapiens	130-133
28583171-9	2017	Okadaic acid and acrylamide also showed statistically significant toxicity in the P19 neurons, but not in the SH-SY5Y cells or the P12 cells.	Acrylamide	17-27	interleukin 23 subunit alpha	Homo sapiens	82-85
28583171-10	2017	CONCLUSIONS: P19 neurons are more sensitive to detect cytotoxicity of MeHg, okadaic acid and acrylamide than retinoic acid-differentiated SH-SY5Y cells and nerve growth factor-treated PC12 cells.	Acrylamide	93-103	interleukin 23 subunit alpha	Homo sapiens	13-16
28341649-4	2017	We carried out an ethyl methanesulfonate (EMS) mutagenesis screen and isolated six independent mutants with attenuated SKN-1-dependent gene activation in response to acrylamide.	Acrylamide	166-176	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	119-124
28283434-7	2017	Tertiary conformational changes probed by acrylamide quenching of Pgp tryptophan fluorescence with the drugs and a nonhydrolyzable ATP analog implied that the STT-bound Pgp must undergo larger conformational changes to hydrolyze ATP than ETT-bound Pgp.	Acrylamide	42-52	ATP binding cassette subfamily B member 1	Homo sapiens	66-69
28283434-7	2017	Tertiary conformational changes probed by acrylamide quenching of Pgp tryptophan fluorescence with the drugs and a nonhydrolyzable ATP analog implied that the STT-bound Pgp must undergo larger conformational changes to hydrolyze ATP than ETT-bound Pgp.	Acrylamide	42-52	ATP binding cassette subfamily B member 1	Homo sapiens	169-172
28283434-7	2017	Tertiary conformational changes probed by acrylamide quenching of Pgp tryptophan fluorescence with the drugs and a nonhydrolyzable ATP analog implied that the STT-bound Pgp must undergo larger conformational changes to hydrolyze ATP than ETT-bound Pgp.	Acrylamide	42-52	ATP binding cassette subfamily B member 1	Homo sapiens	169-172
28436077-0	2017	Neuroprotective effect of epidermal growth factor in experimental acrylamide neuropathy: an electrophysiological approach.	Acrylamide	66-76	epidermal growth factor like 1	Rattus norvegicus	26-49
28436077-2	2017	We investigated the neuroprotective action of EGF in experimental neuropathy induced by acrylamide (ACR).	Acrylamide	88-98	epidermal growth factor like 1	Rattus norvegicus	46-49
28436077-9	2017	The results show a protective effect of EGF in acrylamide-induced neuropathy and support previous studies concerning the neuroprotective action of this peptide.	Acrylamide	47-57	epidermal growth factor like 1	Rattus norvegicus	40-43
28391539-10	2017	However, there were several nominally statistically significant interactions between acrylamide intake and SNPs in the HSD3B1/B2 gene cluster: (rs4659175 (p interaction = 0.04), rs10923823 (p interaction = 0.06) and its proxy rs7546652 (p interaction = 0.05), rs1047303 (p interaction = 0.005), and rs6428830 (p interaction = 0.05).	Acrylamide	85-95	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	119-125
27713515-7	2016	Interaction between acrylamide and SNPs was assessed with Cox proportional hazards analysis, based on 11.3 years of follow-up.	Acrylamide	20-30	cytochrome c oxidase subunit 8A	Homo sapiens	58-61
28379345-0	2017	Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions .	Acrylamide	43-53	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	11-17
28379345-4	2017	CYP2E1 is the only enzyme responsible for the conversion of acrylamide to the highly reactive metabolite glycidamide, which forms adducts with DNA.	Acrylamide	60-70	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
28379345-8	2017	It was determined that CYP2E1 is additionally expressed within the mouse epididymal epithelium, and this localization is responsible for acrylamide-induced dominant lethality.	Acrylamide	137-147	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	23-29
27840054-4	2017	It works by soaking the acrylamide or agarose DNA gel in SGI and nitro blue tetrazolium (NBT) solution that, when exposed to sunlight, produces a purple insoluble formazan precipitate that remains in the gel after exposure to light.	Acrylamide	24-34	semenogelin 1	Homo sapiens	57-60
28925865-10	2017	Fluorescence quenching by acrylamide demonstrated higher stern-volmer constant for exposed HSA.	Acrylamide	26-36	albumin	Homo sapiens	91-94
27641927-9	2016	The drug binds tightly in the ATP-binding pocket of BTK making salt bridges with residues within the hinge that connects the two lobes of the enzyme; then its unsaturated acrylamide group forms a covalent bond with BTK cysteine 481 to form an inactive adduct.	Acrylamide	171-181	Bruton tyrosine kinase	Homo sapiens	52-55
27641927-9	2016	The drug binds tightly in the ATP-binding pocket of BTK making salt bridges with residues within the hinge that connects the two lobes of the enzyme; then its unsaturated acrylamide group forms a covalent bond with BTK cysteine 481 to form an inactive adduct.	Acrylamide	171-181	Bruton tyrosine kinase	Homo sapiens	215-218
28137608-0	2017	Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells.	Acrylamide	27-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-68
28330312-2	2016	L-Asparaginase helps in removing acrylamide found in fried and baked foods that is carcinogenic in nature.	Acrylamide	33-43	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
27931815-0	2016	Evaluation of mutagenicity of acrylamide using RBC Pig-a and PIGRET assays by single peroral dose in rats.	Acrylamide	30-40	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	51-56
27338305-3	2016	We evaluated the potential of acrylamide to induce structural DNA damage and gene mutations in rodents using highly sensitive flow cytometric analysis of micronucleus and Pig-a mutant frequencies, respectively.	Acrylamide	30-40	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	171-176
27474601-1	2016	In the present work, a new flocculant, polyacrylamide-grafted chitosan nanoparticles (NCS-g-PAM), was synthesized by the copolymerization of acrylamide (AM) and chitosan nanoparticle (NCS) under ultraviolet irradiation using 2-hydroxy-4"-(2-hydroxyethoxy)-2-methylpropiophenone as photo-initiator.	Acrylamide	43-53	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	92-95
27713515-9	2016	However, there were nominally statistically significant interactions for SNPs in acrylamide-metabolizing enzymes: CYP2E1 (rs915906 and rs2480258) and the deletions of GSTM1 and GSTT1.	Acrylamide	81-91	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	114-120
27713515-9	2016	However, there were nominally statistically significant interactions for SNPs in acrylamide-metabolizing enzymes: CYP2E1 (rs915906 and rs2480258) and the deletions of GSTM1 and GSTT1.	Acrylamide	81-91	glutathione S-transferase mu 1	Homo sapiens	167-172
27713515-9	2016	However, there were nominally statistically significant interactions for SNPs in acrylamide-metabolizing enzymes: CYP2E1 (rs915906 and rs2480258) and the deletions of GSTM1 and GSTT1.	Acrylamide	81-91	glutathione S-transferase theta 1	Homo sapiens	177-182
27713515-10	2016	Although in need of confirmation, the interactions between acrylamide intake and CYP2E1 SNPs contribute to the evidence for a causal relationship between acrylamide and endometrial cancer risk.	Acrylamide	59-69	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	81-87
27713515-10	2016	Although in need of confirmation, the interactions between acrylamide intake and CYP2E1 SNPs contribute to the evidence for a causal relationship between acrylamide and endometrial cancer risk.	Acrylamide	154-164	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	81-87
27174446-4	2016	Acrylamide was administered to male CD1 mice for three or six months at a dose of 0.18mg/kg bodyweight/day.	Acrylamide	0-10	CD1 antigen complex	Mus musculus	36-39
27580987-0	2016	Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes.	Acrylamide	8-18	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	115-121
27580987-9	2016	This is significant as CYP2E1 is the sole enzyme responsible for conversion of acrylamide to its harmful metabolite glycidamide.	Acrylamide	79-89	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	23-29
25865363-4	2016	l-Asparaginase is also of prospective use in food industry to reduce the formation of acrylamide in fried, roasted or baked food products.	Acrylamide	86-96	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-14
26990578-0	2016	Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors.	Acrylamide	37-47	NLR family pyrin domain containing 3	Homo sapiens	70-75
26990578-3	2016	In this study, the synthesis of acrylamide derivatives and their pharmaco-toxicological evaluation as potential inhibitors of NLRP3-dependent events was undertaken.	Acrylamide	32-42	NLR family pyrin domain containing 3	Homo sapiens	126-131
27505250-5	2016	By RT-PCR, we found that a number of different CD44 transcripts were expressed in human epidermis, and we obtained all these transcripts from DNA bands in agarose and acrylamide gels by cloning.	Acrylamide	167-177	CD44 molecule (Indian blood group)	Homo sapiens	47-51
27497234-5	2016	In comparison with human CYP2E1, camel CYP2E1 more efficiently binds to small toxins as aniline, benzene, catechol, amides, butadiene, toluene and acrylamide.	Acrylamide	147-157	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	25-31
27497234-5	2016	In comparison with human CYP2E1, camel CYP2E1 more efficiently binds to small toxins as aniline, benzene, catechol, amides, butadiene, toluene and acrylamide.	Acrylamide	147-157	cytochrome P450 2E1	Camelus bactrianus	39-45
27617850-5	2016	A natural juxtaposition of two unique cysteines at the binding interface of the NOXA BH3 helix and BFL-1 pocket informed the development of stapled BH3 peptides bearing acrylamide warheads to irreversibly inhibit BFL-1 by covalent targeting.	Acrylamide	169-179	BCL2 related protein A1	Homo sapiens	99-104
27617850-5	2016	A natural juxtaposition of two unique cysteines at the binding interface of the NOXA BH3 helix and BFL-1 pocket informed the development of stapled BH3 peptides bearing acrylamide warheads to irreversibly inhibit BFL-1 by covalent targeting.	Acrylamide	169-179	BCL2 related protein A1	Homo sapiens	213-218
26776011-6	2016	Acrylamide content has a positive correlation with absorbance values at OD294 and OD420 but a negative correlation with the CIB L(*) value of a solution (p&lt;0.01).	Acrylamide	0-10	calcium and integrin binding 1	Homo sapiens	124-127
27014731-1	2016	We previously reported that dietary acrylamide, at doses (10 and 50 mg/kg diet) known to cause rodent tumors, lowered serum total high density lipoprotein and total testosterone, increased serum lipase, and lowered lymphocytes levels together with other hematological parameters in male F344 rats exposed for 10 weeks (doi: 10.1016/j.etap.2014.11.009 [1]).	Acrylamide	36-46	lipase G, endothelial type	Rattus norvegicus	195-201
25827310-5	2016	Estimated exposure to acrylamide based on AAMA and GAMA levels in the whole group of women was 0.16 mug/kg b.w./day (1.15 mug/kg b.w./day, P95).	Acrylamide	22-32	nibrin	Homo sapiens	139-142
26851085-2	2016	For constructing the molecularly imprinted polymer (MIP) layer, amino acid-based thermoresponsive monomer (N-methacryloyl-L-alanine methyl ester, MA-L-Ala-OMe) was mainly selected for the functional monomer along with N,N"-methylenebis(acrylamide) as the crosslinker.	Acrylamide	236-246	mal, T cell differentiation protein	Homo sapiens	146-150
26823559-7	2016	These interactions correlated to drug-induced conformational changes deduced from acrylamide quenching of Pgp tryptophan fluorescence.	Acrylamide	82-92	ATP binding cassette subfamily B member 1	Homo sapiens	106-109
25573798-6	2015	The prototypical neurotoxicant acrylamide affected primarily neurons, impairing synaptic function; our results suggest that gene expression of the presynaptic marker synaptophysin can be used as sensitive endpoint.	Acrylamide	31-41	synaptophysin	Homo sapiens	166-179
26456723-4	2015	Retarded protein migration into acrylamide gels stained for BChE activity was noted with all copolymers as the copolymer-to-protein ratio was increased.	Acrylamide	32-42	butyrylcholinesterase	Homo sapiens	60-64
26481997-2	2015	To improve the stability and sensitivity of glutamate sensors, an electrode modified with glutamate dehydrogenase (GDH)/Ni-Pd/core-shell nanoparticles was developed using the thermal polymerization of acrylamide (AM) to immobilize the synthesized Ni-Pd/core-shell nanoparticles onto a glassy carbon electrode (GCE).	Acrylamide	201-211	glutamate dehydrogenase 1	Homo sapiens	90-113
26481997-2	2015	To improve the stability and sensitivity of glutamate sensors, an electrode modified with glutamate dehydrogenase (GDH)/Ni-Pd/core-shell nanoparticles was developed using the thermal polymerization of acrylamide (AM) to immobilize the synthesized Ni-Pd/core-shell nanoparticles onto a glassy carbon electrode (GCE).	Acrylamide	201-211	glutamate dehydrogenase 1	Homo sapiens	115-118
26068596-1	2015	In this study, we report a series of novel flavone-based sensors that exhibit a superior fluorescence response when interacting with serum albumin in real serum samples and in acrylamide gels.	Acrylamide	176-186	albumin	Homo sapiens	133-146
27452168-4	2016	The concentration of acrylamide in food can be reduced by deamination of asparagine using l-Asparaginase.	Acrylamide	21-31	asparaginase and isoaspartyl peptidase 1	Homo sapiens	90-104
26571264-3	2015	The kinetics of lysozyme aggregation, monitored by Thioflavin T fluorescence, dynamic light scattering and the quenching of tryptophan fluorescence by acrylamide, is described by a sigmoid curve typical of a nucleation-dependent polymerization process.	Acrylamide	151-161	lysozyme	Homo sapiens	16-24
26341906-6	2015	Farnesol treatment significantly ameliorated ACR-mediated histological aberrations and reactive gliosis by downregulating Glial fibrillary acidic protein (GFAP) and Ionizsed calcium-binding adapter molecule-1 (Iba-1) in the cortex, hippocampus and striatum.	Acrylamide	45-48	glial fibrillary acidic protein	Homo sapiens	122-153
26341906-6	2015	Farnesol treatment significantly ameliorated ACR-mediated histological aberrations and reactive gliosis by downregulating Glial fibrillary acidic protein (GFAP) and Ionizsed calcium-binding adapter molecule-1 (Iba-1) in the cortex, hippocampus and striatum.	Acrylamide	45-48	allograft inflammatory factor 1	Homo sapiens	165-208
26341906-7	2015	Further, ACR stimulated increase in levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible form of nitric oxide synthase (iNOS) were considerably decreased by farnesol.	Acrylamide	9-12	tumor necrosis factor	Homo sapiens	81-108
26341906-7	2015	Further, ACR stimulated increase in levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible form of nitric oxide synthase (iNOS) were considerably decreased by farnesol.	Acrylamide	9-12	tumor necrosis factor	Homo sapiens	110-119
26341906-7	2015	Further, ACR stimulated increase in levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible form of nitric oxide synthase (iNOS) were considerably decreased by farnesol.	Acrylamide	9-12	interleukin 1 beta	Homo sapiens	122-139
26341906-7	2015	Further, ACR stimulated increase in levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible form of nitric oxide synthase (iNOS) were considerably decreased by farnesol.	Acrylamide	9-12	interleukin 1 alpha	Homo sapiens	141-149
26341906-7	2015	Further, ACR stimulated increase in levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible form of nitric oxide synthase (iNOS) were considerably decreased by farnesol.	Acrylamide	9-12	nitric oxide synthase 2	Homo sapiens	196-200
25399803-4	2015	Complete modification with more than five PEG chains is observed after incubation with mPEG5k-vinyl sulfone at pH 9, whereas 96% of the protein remains unmodified after incubation with mPEG5k-acrylamide at pH 4.	Acrylamide	192-202	prolyl 4-hydroxylase, transmembrane	Homo sapiens	206-210
25658136-2	2015	They covalently bind a noncatalytic cysteine (Cys797) at the surface of EGFR active site by an acrylamide warhead.	Acrylamide	95-105	epidermal growth factor receptor	Homo sapiens	72-76
25958286-8	2015	The changes in the hydrophobicity of lactoferrin after heat treatments were determined by fluorescence measurement using acrylamide.	Acrylamide	121-131	lactotransferrin	Bos taurus	37-48
25989052-4	2015	Acrylamide exerts its reproductive toxicity via its metabolite glycidamide, a product which is only formed via the cytochrome P450 detoxifying enzyme CYP2E1.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	150-156
25989052-6	2015	Chronic low dose acrylamide exposure in mice relevant to human exposure levels results in significantly increased levels of DNA damage in terms of glycidamide adducts in spermatocytes, the specific germ cell stage where Cyp2e1 is expressed.	Acrylamide	17-27	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	220-226
25989052-11	2015	Resveratrol is an example of an inhibitor of Cyp2e1 which has shown success in reducing damage caused by acrylamide treatment in mice.	Acrylamide	105-115	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	45-51
26177905-1	2015	The purpose of this study was to study the role of neurofilament (NF) mRNA and calpain in NF reduction of acrylamide (ACR) neuropathy.	Acrylamide	106-116	neurofilament light chain	Rattus norvegicus	66-68
26177905-1	2015	The purpose of this study was to study the role of neurofilament (NF) mRNA and calpain in NF reduction of acrylamide (ACR) neuropathy.	Acrylamide	106-116	neurofilament light chain	Rattus norvegicus	90-92
25531190-0	2015	Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent Pathway.	Acrylamide	0-10	activating transcription factor 3	Homo sapiens	73-77
25648844-6	2015	We show that the intermediate filament, vimentin, is involved in C3 uptake, as indicated by the inhibition of C3 internalization by acrylamide, a known vimentin disruption agent.	Acrylamide	132-142	vimentin	Mus musculus	40-48
25648844-6	2015	We show that the intermediate filament, vimentin, is involved in C3 uptake, as indicated by the inhibition of C3 internalization by acrylamide, a known vimentin disruption agent.	Acrylamide	132-142	vimentin	Mus musculus	152-160
25172687-3	2015	The rate of inhibition of acrylamide formation correlated well with the change of trolox equivalent antioxidant capacity (DeltaTEAC) measured by DPPH (R(2)=0.833), ABTS (R(2)=0.860) or FRAP (R(2)=0.824) assay.	Acrylamide	26-36	mechanistic target of rapamycin kinase	Homo sapiens	185-189
25531190-0	2015	Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent Pathway.	Acrylamide	0-10	mitogen-activated protein kinase 14	Homo sapiens	84-87
25531190-0	2015	Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent Pathway.	Acrylamide	0-10	mitogen-activated protein kinase 8	Homo sapiens	88-91
25352525-0	2015	Associations of acrylamide intake with circulating levels of sex hormones and prolactin in premenopausal Japanese women.	Acrylamide	16-26	prolactin	Homo sapiens	78-87
24380568-7	2015	Protein expression levels of cell adhesion molecules [neural cell adhesion molecule (NCAM) and N-cadherin] and extracellular signal-regulated kinases (ERK) in acrylamide-treated KT98/F1B-GFP and U-1240 MG/F1B-GFP neurospheres demonstrated that NCAM decreased and phospho-ERK (pERK) increased, whereas expression of N-cadherin remained unchanged.	Acrylamide	159-169	neural cell adhesion molecule 1	Mus musculus	54-83
24380568-7	2015	Protein expression levels of cell adhesion molecules [neural cell adhesion molecule (NCAM) and N-cadherin] and extracellular signal-regulated kinases (ERK) in acrylamide-treated KT98/F1B-GFP and U-1240 MG/F1B-GFP neurospheres demonstrated that NCAM decreased and phospho-ERK (pERK) increased, whereas expression of N-cadherin remained unchanged.	Acrylamide	159-169	neural cell adhesion molecule 1	Mus musculus	85-89
24380568-7	2015	Protein expression levels of cell adhesion molecules [neural cell adhesion molecule (NCAM) and N-cadherin] and extracellular signal-regulated kinases (ERK) in acrylamide-treated KT98/F1B-GFP and U-1240 MG/F1B-GFP neurospheres demonstrated that NCAM decreased and phospho-ERK (pERK) increased, whereas expression of N-cadherin remained unchanged.	Acrylamide	159-169	cadherin 2	Mus musculus	95-105
24380568-7	2015	Protein expression levels of cell adhesion molecules [neural cell adhesion molecule (NCAM) and N-cadherin] and extracellular signal-regulated kinases (ERK) in acrylamide-treated KT98/F1B-GFP and U-1240 MG/F1B-GFP neurospheres demonstrated that NCAM decreased and phospho-ERK (pERK) increased, whereas expression of N-cadherin remained unchanged.	Acrylamide	159-169	neural cell adhesion molecule 1	Mus musculus	244-248
24380568-7	2015	Protein expression levels of cell adhesion molecules [neural cell adhesion molecule (NCAM) and N-cadherin] and extracellular signal-regulated kinases (ERK) in acrylamide-treated KT98/F1B-GFP and U-1240 MG/F1B-GFP neurospheres demonstrated that NCAM decreased and phospho-ERK (pERK) increased, whereas expression of N-cadherin remained unchanged.	Acrylamide	159-169	cadherin 2	Mus musculus	315-325
24380568-8	2015	Analysis of AKT (protein kinase B, PKB)/beta-catenin pathway showed decrease in phospho-AKT (p-AKT) and cyclin D1 expression in acrylamide-treated neurospheres of KT98/F1B-GFP.	Acrylamide	128-138	thymoma viral proto-oncogene 1	Mus musculus	12-15
24380568-8	2015	Analysis of AKT (protein kinase B, PKB)/beta-catenin pathway showed decrease in phospho-AKT (p-AKT) and cyclin D1 expression in acrylamide-treated neurospheres of KT98/F1B-GFP.	Acrylamide	128-138	thymoma viral proto-oncogene 1	Mus musculus	35-39
24380568-8	2015	Analysis of AKT (protein kinase B, PKB)/beta-catenin pathway showed decrease in phospho-AKT (p-AKT) and cyclin D1 expression in acrylamide-treated neurospheres of KT98/F1B-GFP.	Acrylamide	128-138	catenin (cadherin associated protein), beta 1	Mus musculus	40-52
24380568-8	2015	Analysis of AKT (protein kinase B, PKB)/beta-catenin pathway showed decrease in phospho-AKT (p-AKT) and cyclin D1 expression in acrylamide-treated neurospheres of KT98/F1B-GFP.	Acrylamide	128-138	thymoma viral proto-oncogene 1	Mus musculus	88-91
24380568-8	2015	Analysis of AKT (protein kinase B, PKB)/beta-catenin pathway showed decrease in phospho-AKT (p-AKT) and cyclin D1 expression in acrylamide-treated neurospheres of KT98/F1B-GFP.	Acrylamide	128-138	thymoma viral proto-oncogene 1	Mus musculus	88-91
24380568-8	2015	Analysis of AKT (protein kinase B, PKB)/beta-catenin pathway showed decrease in phospho-AKT (p-AKT) and cyclin D1 expression in acrylamide-treated neurospheres of KT98/F1B-GFP.	Acrylamide	128-138	cyclin D1	Mus musculus	104-113
24380568-10	2015	Coimmunoprecipitation results of KT98/F1B-GFP cell lysates showed that the complex of NCAM and fibroblast growth factor receptor 1 (FGFR1) is present in the neurosphere, and the amount of this complex decreases after acrylamide treatment.	Acrylamide	217-227	fibroblast growth factor receptor 1	Mus musculus	95-130
24380568-10	2015	Coimmunoprecipitation results of KT98/F1B-GFP cell lysates showed that the complex of NCAM and fibroblast growth factor receptor 1 (FGFR1) is present in the neurosphere, and the amount of this complex decreases after acrylamide treatment.	Acrylamide	217-227	fibroblast growth factor receptor 1	Mus musculus	132-137
26133355-3	2015	The results show that these propenamides potently inhibited HDAC2 with IC50 values in sub-micromolar range, approximately 10-fold lower than that of SAHA (also known as suberoylanilohydroxamic acid).	Acrylamide	28-40	histone deacetylase 2	Homo sapiens	60-65
25473820-4	2015	Acrylamide at the higher doses (10 and 50mg/kg diet) significantly lowered (p&lt;0.05) serum total high density lipoprotein and total testosterone and increased serum lipase in comparison to the control.	Acrylamide	0-10	lipase G, endothelial type	Rattus norvegicus	167-173
26285750-7	2015	Here, we describe the details of Phosphate affinity SDS-PAGE of ERK5 using acrylamide-pendant Phos-tag .	Acrylamide	75-85	mitogen-activated protein kinase 7	Homo sapiens	64-68
26043996-3	2015	When the Ro 60-coated nitrocellulose was laid over the surface of the IEF gel, the antibodies present on the surface of the acrylamide gel bound the Ro antigen on the nitrocellulose.	Acrylamide	124-134	Ro60, Y RNA binding protein	Homo sapiens	9-14
24508089-1	2014	Agar has been modified by microwave assisted grafting with acrylamide monomer, resulting in poly acrylamide grafted agar (Ag-g-PAM).	Acrylamide	59-69	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	127-130
25240868-9	2014	Furthermore, quenching the intrinsic fluorescence of ALAS with acrylamide at pH1.0 and 9.5 yielded subtly different dynamic quenching constants.	Acrylamide	63-73	5'-aminolevulinate synthase 1	Homo sapiens	53-57
25456387-6	2014	On the other hand, compounds 2 and 6 containing acrylamide or vinylsulfonamide groups are reversible towards FLT3 binding, and are potent and selective inhibitors of mutant FLT3-ITD versus wt-FLT3.	Acrylamide	48-58	fms related receptor tyrosine kinase 3	Homo sapiens	109-113
25456387-6	2014	On the other hand, compounds 2 and 6 containing acrylamide or vinylsulfonamide groups are reversible towards FLT3 binding, and are potent and selective inhibitors of mutant FLT3-ITD versus wt-FLT3.	Acrylamide	48-58	fms related receptor tyrosine kinase 3	Homo sapiens	173-177
25456387-6	2014	On the other hand, compounds 2 and 6 containing acrylamide or vinylsulfonamide groups are reversible towards FLT3 binding, and are potent and selective inhibitors of mutant FLT3-ITD versus wt-FLT3.	Acrylamide	48-58	fms related receptor tyrosine kinase 3	Homo sapiens	173-177
24937185-6	2014	Thus, we now developed a second generation compounds that devoid of the acrylamide functionality and possess high potency and improved (&gt;1000-fold) selectivity to EP2 over other prostanoid receptors.	Acrylamide	72-82	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	166-169
24279610-0	2014	Telomerase activity-independent function of telomerase reverse transcriptase is involved in acrylamide-induced neuron damage.	Acrylamide	92-102	telomerase reverse transcriptase	Rattus norvegicus	44-76
24747376-5	2014	Measurement of NOS activities indicated that total NOS (TNOS), iNOS and eNOS activities were significantly increased (P&lt;0.05) with increasing doses of acrylamide.	Acrylamide	154-164	nitric oxide synthase 2, inducible	Mus musculus	63-67
24861763-2	2014	In this study, lysozyme molecularly imprinted polymers (Lys-MIPs) were successfully prepared by the entrapment method with lysozyme as the template molecule, acrylamide as the functional monomer and N,N-methylenebisacrylamide as the cross-linker.	Acrylamide	158-168	lysozyme	Homo sapiens	15-23
25126019-6	2014	RESULTS: The administration of acrylamide resulted in significant elevation in testicular and epididymal malondialdehyde level (MDA) and significant reduction in the level of reduced glutathione (GSH) and the activities of glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GR).	Acrylamide	31-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	223-248
25126019-6	2014	RESULTS: The administration of acrylamide resulted in significant elevation in testicular and epididymal malondialdehyde level (MDA) and significant reduction in the level of reduced glutathione (GSH) and the activities of glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GR).	Acrylamide	31-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	250-253
25126019-6	2014	RESULTS: The administration of acrylamide resulted in significant elevation in testicular and epididymal malondialdehyde level (MDA) and significant reduction in the level of reduced glutathione (GSH) and the activities of glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GR).	Acrylamide	31-41	glutathione-disulfide reductase	Rattus norvegicus	289-310
25126019-6	2014	RESULTS: The administration of acrylamide resulted in significant elevation in testicular and epididymal malondialdehyde level (MDA) and significant reduction in the level of reduced glutathione (GSH) and the activities of glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GR).	Acrylamide	31-41	glutathione-disulfide reductase	Rattus norvegicus	312-314
25095413-1	2014	Cationic Polyacrylamide P(AM-DAC-BA) was synthesized by UV initiation, with acrylamide (AM), acryloyloxyethyl trimethyl ammonium chloride (DAC), butyl acrylate (BA) as the monomers.	Acrylamide	13-23	arylacetamide deacetylase	Homo sapiens	29-32
24508477-6	2014	Only in HepG2 cells, low concentration of acrylamide was able to induce CYP2E1 expression significantly.	Acrylamide	42-52	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	72-78
24508477-7	2014	Knockdown of CYP2E1 restrained acrylamide to increase viability of HepG2 cells.	Acrylamide	31-41	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	13-19
24508477-8	2014	In addition, acrylamide raised expression of epidermal growth factor receptor (EGFR), cyclin D1 and nuclear factor-kappaB (NF-kappaB), which contributed to cell proliferation.	Acrylamide	13-23	epidermal growth factor receptor	Homo sapiens	45-77
24508477-8	2014	In addition, acrylamide raised expression of epidermal growth factor receptor (EGFR), cyclin D1 and nuclear factor-kappaB (NF-kappaB), which contributed to cell proliferation.	Acrylamide	13-23	epidermal growth factor receptor	Homo sapiens	79-83
24508477-8	2014	In addition, acrylamide raised expression of epidermal growth factor receptor (EGFR), cyclin D1 and nuclear factor-kappaB (NF-kappaB), which contributed to cell proliferation.	Acrylamide	13-23	cyclin D1	Homo sapiens	86-121
24508477-8	2014	In addition, acrylamide raised expression of epidermal growth factor receptor (EGFR), cyclin D1 and nuclear factor-kappaB (NF-kappaB), which contributed to cell proliferation.	Acrylamide	13-23	nuclear factor kappa B subunit 1	Homo sapiens	123-132
24380568-10	2015	Coimmunoprecipitation results of KT98/F1B-GFP cell lysates showed that the complex of NCAM and fibroblast growth factor receptor 1 (FGFR1) is present in the neurosphere, and the amount of this complex decreases after acrylamide treatment.	Acrylamide	217-227	neural cell adhesion molecule 1	Mus musculus	86-90
25034963-2	2014	Here we report on the imprinting of fluorescently-labeled maltose binding protein (MBP) in acrylamide (AAm)/N-isopropylacrylamide (NIPAm) hydrogels.	Acrylamide	91-101	myelin basic protein	Homo sapiens	58-81
25034963-2	2014	Here we report on the imprinting of fluorescently-labeled maltose binding protein (MBP) in acrylamide (AAm)/N-isopropylacrylamide (NIPAm) hydrogels.	Acrylamide	91-101	myelin basic protein	Homo sapiens	83-86
25034963-2	2014	Here we report on the imprinting of fluorescently-labeled maltose binding protein (MBP) in acrylamide (AAm)/N-isopropylacrylamide (NIPAm) hydrogels.	Acrylamide	103-106	myelin basic protein	Homo sapiens	58-81
25034963-2	2014	Here we report on the imprinting of fluorescently-labeled maltose binding protein (MBP) in acrylamide (AAm)/N-isopropylacrylamide (NIPAm) hydrogels.	Acrylamide	103-106	myelin basic protein	Homo sapiens	83-86
24731346-1	2014	A sol-gel hybrid sorbent, methyltrimethoxysilane-tetraethoxysilane (MTMOS-TEOS) was successfully used as new dispersive solid phase extraction (dSPE) sorbent material in the determination of acrylamide in several Sudanese foods and analysis using GC-MS. Several important dSPE parameters were optimised.	Acrylamide	191-201	Spatzle-Processing Enzyme	Drosophila melanogaster	144-148
24731346-1	2014	A sol-gel hybrid sorbent, methyltrimethoxysilane-tetraethoxysilane (MTMOS-TEOS) was successfully used as new dispersive solid phase extraction (dSPE) sorbent material in the determination of acrylamide in several Sudanese foods and analysis using GC-MS. Several important dSPE parameters were optimised.	Acrylamide	191-201	Spatzle-Processing Enzyme	Drosophila melanogaster	272-276
24731346-6	2014	The proposed MTMOS-TEOS dSPE method is direct and safe for acrylamide analysis, showed reliable method validation performances and good cleanup effects.	Acrylamide	59-69	Spatzle-Processing Enzyme	Drosophila melanogaster	24-28
24928766-4	2014	We show that several days exposure to 1-100 muM acrylamide resulted in altered morphology, irregular contraction patterns, and an increase in the amount of immunoreactive signal for connexin 43 at cell junctions.	Acrylamide	48-58	gap junction protein, alpha 1	Rattus norvegicus	182-193
24282135-9	2014	Under optimal conditions, the limit of detection (S/N = 3) of this method for acrylamide was 2.1 microg kg(-1), and the RSD for five replicate extractions of 50 muL(-1) acrylamide was 4.5%.	Acrylamide	169-179	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	161-167
24967582-8	2014	The involvement of vimentin in uptake of C3 was further supported by the findings that the vimentin disruptor acrylamide blocked uptake of C3.	Acrylamide	110-120	vimentin	Mus musculus	19-27
24967582-8	2014	The involvement of vimentin in uptake of C3 was further supported by the findings that the vimentin disruptor acrylamide blocked uptake of C3.	Acrylamide	110-120	vimentin	Mus musculus	91-99
24788432-4	2014	CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA.	Acrylamide	19-29	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
24788432-4	2014	CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA.	Acrylamide	60-70	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
24788432-5	2014	Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide.	Acrylamide	39-49	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	124-130
24788432-5	2014	Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide.	Acrylamide	150-160	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	124-130
24788432-7	2014	Additionally, CYP2E1 gene expression was upregulated in these cells following in vitro acrylamide exposure (1 microM, 18 h).	Acrylamide	87-97	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	14-20
24398672-0	2014	Dietary acrylamide intake and the risk of colorectal cancer with specific mutations in KRAS and APC.	Acrylamide	8-18	KRAS proto-oncogene, GTPase	Homo sapiens	87-91
24695527-8	2014	Thus vacuolar invertase silencing can minimize a long-standing French fry quality problem while providing consumers with attractive products that reduce health concerns related to dietary acrylamide.	Acrylamide	188-198	beta-fructosidase	Solanum tuberosum	5-23
24318646-0	2014	Cytotoxic effects of acrylamide in nerve growth factor or fibroblast growth factor 1-induced neurite outgrowth in PC12 cells.	Acrylamide	21-31	nerve growth factor	Rattus norvegicus	35-54
24462985-6	2014	Secondly, it decreased activation energy for conversion of 3-aminopropionamide (3-APA) to acrylamide (from 173.2 to 136.6kJ/mol), and enhances deamination from 3-APA.	Acrylamide	90-100	glutamyl aminopeptidase	Homo sapiens	82-85
24318646-0	2014	Cytotoxic effects of acrylamide in nerve growth factor or fibroblast growth factor 1-induced neurite outgrowth in PC12 cells.	Acrylamide	21-31	fibroblast growth factor 1	Rattus norvegicus	58-84
24318646-2	2014	The aims of this study are to investigate the cytotoxicity and neurite outgrowth inhibition of acrylamide in nerve growth factor (NGF)- or fibroblast growth factor 1 (FGF1)-mediated neural development of PC12 cells.	Acrylamide	95-105	nerve growth factor	Rattus norvegicus	109-128
24318646-2	2014	The aims of this study are to investigate the cytotoxicity and neurite outgrowth inhibition of acrylamide in nerve growth factor (NGF)- or fibroblast growth factor 1 (FGF1)-mediated neural development of PC12 cells.	Acrylamide	95-105	nerve growth factor	Rattus norvegicus	130-133
24318646-2	2014	The aims of this study are to investigate the cytotoxicity and neurite outgrowth inhibition of acrylamide in nerve growth factor (NGF)- or fibroblast growth factor 1 (FGF1)-mediated neural development of PC12 cells.	Acrylamide	95-105	fibroblast growth factor 1	Rattus norvegicus	139-165
24318646-2	2014	The aims of this study are to investigate the cytotoxicity and neurite outgrowth inhibition of acrylamide in nerve growth factor (NGF)- or fibroblast growth factor 1 (FGF1)-mediated neural development of PC12 cells.	Acrylamide	95-105	fibroblast growth factor 1	Rattus norvegicus	167-171
24318646-3	2014	MTS assay showed that acrylamide treatment suppresses NGF- or FGF1-induced PC12 cell proliferation in a time- and dose-dependent manner.	Acrylamide	22-32	nerve growth factor	Rattus norvegicus	54-57
24318646-3	2014	MTS assay showed that acrylamide treatment suppresses NGF- or FGF1-induced PC12 cell proliferation in a time- and dose-dependent manner.	Acrylamide	22-32	fibroblast growth factor 1	Rattus norvegicus	62-66
24318646-4	2014	Quantification of neurite outgrowth demonstrated that 0.5 mM acrylamide treatment resulted in significant decrease in differentiation of NGF- or FGF1-stimulated PC12 cells.	Acrylamide	61-71	nerve growth factor	Rattus norvegicus	137-140
24318646-4	2014	Quantification of neurite outgrowth demonstrated that 0.5 mM acrylamide treatment resulted in significant decrease in differentiation of NGF- or FGF1-stimulated PC12 cells.	Acrylamide	61-71	fibroblast growth factor 1	Rattus norvegicus	145-149
24318646-7	2014	Acrylamide (0.5 mM) decreases the NGF-induced activation of AKT-CREB but not ERK-STAT3 within 20 min.	Acrylamide	0-10	nerve growth factor	Rattus norvegicus	34-37
24318646-7	2014	Acrylamide (0.5 mM) decreases the NGF-induced activation of AKT-CREB but not ERK-STAT3 within 20 min.	Acrylamide	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
24318646-7	2014	Acrylamide (0.5 mM) decreases the NGF-induced activation of AKT-CREB but not ERK-STAT3 within 20 min.	Acrylamide	0-10	cAMP responsive element binding protein 1	Rattus norvegicus	64-68
24318646-8	2014	Similarly, acrylamide (0.5 mM) decreases the FGF1-induced activation of AKT-CREB within 20 min.	Acrylamide	11-21	fibroblast growth factor 1	Rattus norvegicus	45-49
24318646-8	2014	Similarly, acrylamide (0.5 mM) decreases the FGF1-induced activation of AKT-CREB within 20 min.	Acrylamide	11-21	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
24318646-8	2014	Similarly, acrylamide (0.5 mM) decreases the FGF1-induced activation of AKT-CREB within 20 min.	Acrylamide	11-21	cAMP responsive element binding protein 1	Rattus norvegicus	76-80
24318646-9	2014	In contrast to the NGF treatment, the ERK-STAT3 activation that was induced by FGF1 was slightly reduced by 0.5 mM acrylamide.	Acrylamide	115-125	nerve growth factor	Rattus norvegicus	19-22
24318646-9	2014	In contrast to the NGF treatment, the ERK-STAT3 activation that was induced by FGF1 was slightly reduced by 0.5 mM acrylamide.	Acrylamide	115-125	signal transducer and activator of transcription 3	Rattus norvegicus	42-47
24318646-9	2014	In contrast to the NGF treatment, the ERK-STAT3 activation that was induced by FGF1 was slightly reduced by 0.5 mM acrylamide.	Acrylamide	115-125	fibroblast growth factor 1	Rattus norvegicus	79-83
24318646-10	2014	We further showed that PI3K inhibitor (LY294002), but not MEK inhibitor (U0126), could synergize with acrylamide (0.5 mM) to reduce the cell viability and neurite outgrowth in NGF- or FGF1-stimulated PC12 cells.	Acrylamide	102-112	nerve growth factor	Rattus norvegicus	176-179
24318646-10	2014	We further showed that PI3K inhibitor (LY294002), but not MEK inhibitor (U0126), could synergize with acrylamide (0.5 mM) to reduce the cell viability and neurite outgrowth in NGF- or FGF1-stimulated PC12 cells.	Acrylamide	102-112	fibroblast growth factor 1	Rattus norvegicus	184-188
24318646-11	2014	Moreover, acrylamide (0.5 mM) increased reactive oxygen species (ROS) activities in NGF- or FGF1-stimulated PC12 cells.	Acrylamide	10-20	nerve growth factor	Rattus norvegicus	84-87
24387079-3	2014	A considerable achievement during the past 2 years was the development of targeted therapies against EGFR using small-molecule inhibitors such as quinazoline derivatives, pyrimidine derivatives, thiazole derivatives, acrylamide derivatives and urea derivatives.	Acrylamide	217-227	epidermal growth factor receptor	Homo sapiens	101-105
25206854-4	2014	Transthyretin levels in cerebrospinal fluid began to decline on day 7 after acrylamide exposure.	Acrylamide	76-86	transthyretin	Rattus norvegicus	0-13
24318646-11	2014	Moreover, acrylamide (0.5 mM) increased reactive oxygen species (ROS) activities in NGF- or FGF1-stimulated PC12 cells.	Acrylamide	10-20	fibroblast growth factor 1	Rattus norvegicus	92-96
24318646-13	2014	Together, our findings reveal that NGF- or FGF1-stimulation of the neuronal differentiation of PC12 cells is attenuated by acrylamide through the inhibition of PI3K-AKT-CREB signaling, along with the production of ROS.	Acrylamide	123-133	nerve growth factor	Rattus norvegicus	35-38
24318646-13	2014	Together, our findings reveal that NGF- or FGF1-stimulation of the neuronal differentiation of PC12 cells is attenuated by acrylamide through the inhibition of PI3K-AKT-CREB signaling, along with the production of ROS.	Acrylamide	123-133	fibroblast growth factor 1	Rattus norvegicus	43-47
24318646-13	2014	Together, our findings reveal that NGF- or FGF1-stimulation of the neuronal differentiation of PC12 cells is attenuated by acrylamide through the inhibition of PI3K-AKT-CREB signaling, along with the production of ROS.	Acrylamide	123-133	AKT serine/threonine kinase 1	Rattus norvegicus	165-168
24318646-13	2014	Together, our findings reveal that NGF- or FGF1-stimulation of the neuronal differentiation of PC12 cells is attenuated by acrylamide through the inhibition of PI3K-AKT-CREB signaling, along with the production of ROS.	Acrylamide	123-133	cAMP responsive element binding protein 1	Rattus norvegicus	169-173
24266513-5	2013	Circular dichroism spectroscopy, acrylamide quenching, and amide hydrogen-deuterium exchange mass spectrometry experiments indicate that the loss of activity is caused by the introduction of local disorder at the active site of GSTP1-1.	Acrylamide	33-43	glutathione S-transferase pi 1	Homo sapiens	228-235
23994668-10	2013	Acrylamide-induced apoptosis may be associated with destruction of vimentin filaments.	Acrylamide	0-10	vimentin	Cavia porcellus	67-75
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	Acrylamide	91-101	galactosidase beta 1	Homo sapiens	13-31
24180271-6	2013	Vinyl amide 2 and vinyl sulfonamide 4 potently inhibit TTR dissociation and amyloid fibril formation in vitro.	Acrylamide	0-11	transthyretin	Homo sapiens	55-58
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	Acrylamide	91-101	lactase	Homo sapiens	33-40
23983241-3	2013	METHODS: We cross-sectionally investigated the relationship between acrylamide intake and plasma levels of sex hormones and sex hormone-binding globulin (SHBG) among 687 postmenopausal and 1,300 premenopausal controls from nested case-control studies within the Nurses" Health Studies.	Acrylamide	68-78	sex hormone binding globulin	Homo sapiens	124-152
23983241-3	2013	METHODS: We cross-sectionally investigated the relationship between acrylamide intake and plasma levels of sex hormones and sex hormone-binding globulin (SHBG) among 687 postmenopausal and 1,300 premenopausal controls from nested case-control studies within the Nurses" Health Studies.	Acrylamide	68-78	sex hormone binding globulin	Homo sapiens	154-158
23665163-9	2013	Interestingly, PADI4 was up-regulated by various stresses such as H2O2, acrylamide, and tunicamycin in neuroblastoma SK-N-SH cells but inhibited by RG.	Acrylamide	72-82	peptidyl arginine deiminase 4	Homo sapiens	15-20
23494399-0	2013	Construction of an improved amperometric acrylamide biosensor based on hemoglobin immobilized onto carboxylated multi-walled carbon nanotubes/iron oxide nanoparticles/chitosan composite film.	Acrylamide	41-51	hemoglobin	Solanum tuberosum	71-81
23494399-1	2013	A method is described for construction of an improved amperometric acrylamide biosensor based on covalent immobilization of hemoglobin (Hb) onto nanocomposite of carboxylated multi-walled carbon nanotubes (cMWCNT) and iron oxide nanoparticles (Fe3O4NPs) electrodeposited onto Au electrode through chitosan (CHIT) film.	Acrylamide	67-77	hemoglobin	Solanum tuberosum	124-134
24031039-6	2013	Two compounds, an acetamide and an acrylamide derivative, exhibited good binding affinities at both the human melatonin (MT) receptors and the serotonin 5-HT2C receptor subtype, with pKi values of 7.96 and 7.95 against MT1, 7.86 and 8.68 against MT2, and 6.64 and 6.44 against 5-HT2C, respectively.	Acrylamide	35-45	5-hydroxytryptamine receptor 2C	Homo sapiens	143-168
24031039-6	2013	Two compounds, an acetamide and an acrylamide derivative, exhibited good binding affinities at both the human melatonin (MT) receptors and the serotonin 5-HT2C receptor subtype, with pKi values of 7.96 and 7.95 against MT1, 7.86 and 8.68 against MT2, and 6.64 and 6.44 against 5-HT2C, respectively.	Acrylamide	35-45	metallothionein 1I, pseudogene	Homo sapiens	219-222
24031039-6	2013	Two compounds, an acetamide and an acrylamide derivative, exhibited good binding affinities at both the human melatonin (MT) receptors and the serotonin 5-HT2C receptor subtype, with pKi values of 7.96 and 7.95 against MT1, 7.86 and 8.68 against MT2, and 6.64 and 6.44 against 5-HT2C, respectively.	Acrylamide	35-45	metallothionein 2A	Homo sapiens	246-249
24031039-6	2013	Two compounds, an acetamide and an acrylamide derivative, exhibited good binding affinities at both the human melatonin (MT) receptors and the serotonin 5-HT2C receptor subtype, with pKi values of 7.96 and 7.95 against MT1, 7.86 and 8.68 against MT2, and 6.64 and 6.44 against 5-HT2C, respectively.	Acrylamide	35-45	5-hydroxytryptamine receptor 2C	Homo sapiens	153-159
23860381-1	2013	The purpose of this study was to investigate the adsorption of lead (Pb(II)) onto acrylamide (AM) doped TiO2 nanocomposites (Ti-AM) using batch techniques for evaluation of isothermal and kinetic properties.	Acrylamide	82-92	submaxillary gland androgen regulated protein 3B	Homo sapiens	69-75
23541560-1	2013	Biodegradable flocculants of Gum ghatti (Gg) with acrylamide (AAm) were prepared through graft co-polymerization technique using potassium persulphate (KPS)-ascorbic acid (ABC) redox pair as initiator and N,N"-methylene-bis-acrylamide (MBA) as a crosslinker.	Acrylamide	50-60	OTU deubiquitinase with linear linkage specificity	Homo sapiens	29-32
23541560-1	2013	Biodegradable flocculants of Gum ghatti (Gg) with acrylamide (AAm) were prepared through graft co-polymerization technique using potassium persulphate (KPS)-ascorbic acid (ABC) redox pair as initiator and N,N"-methylene-bis-acrylamide (MBA) as a crosslinker.	Acrylamide	62-65	OTU deubiquitinase with linear linkage specificity	Homo sapiens	29-32
23287710-4	2013	In conclusion our in vitro results demonstrate that exposure to high doses of glycidamide/acrylamide - exceeding the dietary exposure of the general population by far - can induce genes with growth promoting potential like the oncogene cMYC and genes involved in the MAPK pathway.	Acrylamide	90-100	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	236-240
23519028-7	2013	However, Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised.	Acrylamide	65-75	leucine rich repeat and sterile alpha motif containing 1	Mus musculus	9-15
23421503-7	2013	The results also demonstrated that depression of StvacINV1 activity through overexpression of StInvInh2A and StInvInh2B weakened accumulation of RS and acrylamide in cold-stored tubers and consequently improved the chip quality.	Acrylamide	152-162	cell wall / vacuolar inhibitor of fructosidase 1	Solanum tuberosum	94-104
23256458-0	2013	The role of human cytochrome P450 enzymes in metabolism of acrylamide in vitro.	Acrylamide	59-69	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-33
23463416-4	2013	Up to 45% w/v of glycerol, 8% w/v of acrylamide content, and 25 h of electrophoretic time at 70 V allowed a clear separation of MHC isoforms.	Acrylamide	37-47	major histocompatibility complex, class I, C	Homo sapiens	128-131
23410159-4	2013	The temperature-induced changes induced on LF conformation were analyzed through intrinsic and ANS fluorescence parameters (intensity, maximum position, and parameter A value), the phase diagram method, and quenching experiments using acrylamide and iodide.	Acrylamide	235-245	lactotransferrin	Bos taurus	43-45
23776906-1	2013	OBJECTIVE: To study pregnancy outcomes in relation to thyroid peroxidase antibody (TPOAb) status with optimum thyroxine replacement for subclinical hypothyroidism.	Acrylamide	102-109	thyroid peroxidase	Homo sapiens	54-72
23123033-5	2013	Scanning Electron Microscope (SEM) images indicated that poly(St-co-MMA) particle was lobed morphology coated by cross-linked poly(AAm-co-AAc) shell.	Acrylamide	131-134	glycine-N-acyltransferase	Homo sapiens	138-141
24088175-3	2013	After 48 h, chondrocytes treated with acrylamide showed changes in actin immunolocalisation and shrinkage, loss of tubulin compartmentalisation and vimentin collapse and redistribution.	Acrylamide	38-48	vimentin	Rattus norvegicus	148-156
23229640-4	2013	Under the conditions selected recoveries close to 100% were achieved while LODs and LOQs equal to 5 and 10 mug/L for acrylamide in brewed coffee were obtained.	Acrylamide	117-127	TARBP2 subunit of RISC loading complex	Homo sapiens	84-88
24088175-6	2013	However, it is also possible that HIEO prevents vimentin disorganisation by chemical interaction with acrylamide.	Acrylamide	102-112	vimentin	Rattus norvegicus	48-56
24900424-1	2012	We report a series of irreversible transglutaminase 2 inhibitors starting from a known lysine dipeptide bearing an acrylamide warhead.	Acrylamide	115-125	transglutaminase 2	Homo sapiens	35-53
22734927-5	2013	Here we show that, during cold storage, overexpression of the INH2 vacuolar invertase inhibitor gene in CIS-susceptible potato tubers reduced acid invertase activity, the accumulation of reducing sugars and the generation of acrylamide in subsequent fry tests.	Acrylamide	225-235	cell wall / vacuolar inhibitor of fructosidase 1-like	Solanum tuberosum	62-66
22980859-3	2012	Acrylamide was extracted by 10 mL of water and the extract purified by a single SPE column consisting of 0.5 g of an in-house prepared mixture of C18, strong cation (SCX) and anion exchange (SAX) sorbents in the ratio 2/1.5/1.5 (w/w/w).	Acrylamide	0-10	scleraxis bHLH transcription factor	Homo sapiens	166-169
23100250-3	2012	In this study we analyzed the phosphorylation sites of p57/coronin-1 derived from HL60 human leukemic cells by MALDI-TOF-MS, two-dimensional gel electrophoresis, and Phos-tag  acrylamide gel electrophoresis in combination with site-directed mutagenesis and identified Ser-2 and Thr-412 as major phosphorylation sites.	Acrylamide	176-186	coronin 1A	Homo sapiens	55-58
23069881-0	2012	The modifying effect of CYP2E1, GST, and mEH genotypes on the formation of hemoglobin adducts of acrylamide and glycidamide in workers exposed to acrylamide.	Acrylamide	97-107	epoxide hydrolase 1, microsomal	Mus musculus	41-44
22801078-13	2012	CONCLUSION: Acrylamide could increased the BCB permeability of rats, which may be involved in the central nervous injury induced by ACR.	Acrylamide	12-22	acrosin	Rattus norvegicus	132-135
22392284-0	2012	Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells.	Acrylamide	18-28	glutathione S-transferase kappa 1	Homo sapiens	52-77
22392284-2	2012	Acrylamide is metabolized into glycidamide by CYP2E1.	Acrylamide	0-10	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-52
22392284-3	2012	However, very few studies regarding the effects of acrylamide on cytochrome P450 and Glutathione S-Transferase (GST) isozymes have been pursued.	Acrylamide	51-61	glutathione S-transferase kappa 1	Homo sapiens	85-110
22392284-3	2012	However, very few studies regarding the effects of acrylamide on cytochrome P450 and Glutathione S-Transferase (GST) isozymes have been pursued.	Acrylamide	51-61	glutathione S-transferase kappa 1	Homo sapiens	112-115
22392284-4	2012	The aim of this study is to elucidate the effects of acrylamide on cytochrome P450 and GST isozymes in HepG2 cell line.	Acrylamide	53-63	glutathione S-transferase kappa 1	Homo sapiens	87-90
22392284-7	2012	Similarly, CYP2E1-associated aniline 4-hydroxylase (ANH) activity, protein levels, and mRNA levels increased 2.1- and 2.6-fold, 2.4- and 3.2-fold, and 1.4- and 1.9-fold following 1.25 and 2.5 mM acrylamide treatments, respectively.	Acrylamide	195-205	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	11-17
22392284-8	2012	In addition, GST-mu activity was increased 2.4- and 5.1-fold by acrylamide.	Acrylamide	64-74	glutathione S-transferase kappa 1	Homo sapiens	13-16
22392284-9	2012	Moreover, GST-mu mRNA and protein levels increased twofold as a result of acrylamide treatment.	Acrylamide	74-84	glutathione S-transferase kappa 1	Homo sapiens	10-13
22392284-11	2012	In conclusion, human cell exposure to acrylamide causes an increase in the levels of carcinogenicity and toxicity and a disturbance in drug metabolism, possibly due to complex effects on P450 and GST isozymes.	Acrylamide	38-48	glutathione S-transferase kappa 1	Homo sapiens	196-199
22950636-5	2012	Acrylamide formation and browning index in cookies were considered as the first-order reaction kinetics and the reaction rate constants, k, were in the range of 0.023 to 0.077 (min(-1) ) and 0.019 to 0.063 (min(-1) ), respectively.	Acrylamide	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	177-184
22950636-5	2012	Acrylamide formation and browning index in cookies were considered as the first-order reaction kinetics and the reaction rate constants, k, were in the range of 0.023 to 0.077 (min(-1) ) and 0.019 to 0.063 (min(-1) ), respectively.	Acrylamide	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	207-214
22726556-1	2012	Simultaneous silencing of asparagine synthetase (Ast)-1 and -2 limits asparagine (ASN) formation and, consequently, reduces the acrylamide-forming potential of tubers.	Acrylamide	128-138	asparagine synthetase [glutamine-hydrolyzing]	Solanum tuberosum	26-62
23322975-12	2012	RESULTS AND DISCUSSION: The obtained results revealed that, acrylamide caused significant increases in MDA and decrease of GSH level, SOD and CAT activity due to the oxidative stress induced by acrylamide on membrane polyunsaturated fatty acids in rat"s stomach, liver and kidney while administration of CPF aqueous extract, was significantly ameliorated the increased levels of MDA and decline of GSH, SOD and CAT activity in the stomach, liver and kidney tissues caused by acrylamide toxicity.	Acrylamide	60-70	catalase	Rattus norvegicus	142-145
23322975-12	2012	RESULTS AND DISCUSSION: The obtained results revealed that, acrylamide caused significant increases in MDA and decrease of GSH level, SOD and CAT activity due to the oxidative stress induced by acrylamide on membrane polyunsaturated fatty acids in rat"s stomach, liver and kidney while administration of CPF aqueous extract, was significantly ameliorated the increased levels of MDA and decline of GSH, SOD and CAT activity in the stomach, liver and kidney tissues caused by acrylamide toxicity.	Acrylamide	60-70	catalase	Rattus norvegicus	411-414
23322975-12	2012	RESULTS AND DISCUSSION: The obtained results revealed that, acrylamide caused significant increases in MDA and decrease of GSH level, SOD and CAT activity due to the oxidative stress induced by acrylamide on membrane polyunsaturated fatty acids in rat"s stomach, liver and kidney while administration of CPF aqueous extract, was significantly ameliorated the increased levels of MDA and decline of GSH, SOD and CAT activity in the stomach, liver and kidney tissues caused by acrylamide toxicity.	Acrylamide	194-204	catalase	Rattus norvegicus	411-414
23322975-12	2012	RESULTS AND DISCUSSION: The obtained results revealed that, acrylamide caused significant increases in MDA and decrease of GSH level, SOD and CAT activity due to the oxidative stress induced by acrylamide on membrane polyunsaturated fatty acids in rat"s stomach, liver and kidney while administration of CPF aqueous extract, was significantly ameliorated the increased levels of MDA and decline of GSH, SOD and CAT activity in the stomach, liver and kidney tissues caused by acrylamide toxicity.	Acrylamide	194-204	catalase	Rattus norvegicus	411-414
22687503-5	2012	This change in fluorescence emission was paralleled by a decrease in accessibility toward acrylamide and phospholipids carrying a spin-label at the acyl chain; the tryptophan residue of bovicin HC5 was located near the twelfth position of the membrane phospholipid acyl chains.	Acrylamide	90-100	CYCS pseudogene 1	Homo sapiens	194-197
22543296-7	2012	Acrylamide and SNP reduced ALP activity and collagen type I mRNA levels but mRNA levels for bone sialoprotein and osteopontin increased in SNP treated cells and remained unchanged in acrylamide.	Acrylamide	0-10	alkaline phosphatase, placental	Homo sapiens	27-30
21878450-1	2012	Acrylamide is oxidized by cytochrome P450 2E1 (CYP2E1) to its epoxide form, glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activities.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	26-45
21878450-1	2012	Acrylamide is oxidized by cytochrome P450 2E1 (CYP2E1) to its epoxide form, glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activities.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	47-53
22070093-8	2012	It shows that manipulation of TaGCN2 gene expression could be used to reduce free asparagine accumulation in wheat grain and the risk of acrylamide formation in wheat products.	Acrylamide	137-147	eIF-2-alpha kinase GCN2	Triticum aestivum	30-36
22280453-2	2012	The acrylamide fragment, a commonly employed warhead, effectively alkylates Cys797 of EGFR, but its reactivity can cause rapid metabolic deactivation or nonspecific reactions with off-targets.	Acrylamide	4-14	epidermal growth factor receptor	Homo sapiens	86-90
22280453-4	2012	Some of these compounds proved to be as efficient as their acrylamide analogues in inhibiting EGFR-TK (TK = tyrosine kinase) autophosphorylation in A549 lung cancer cells.	Acrylamide	59-69	epidermal growth factor receptor	Homo sapiens	94-98
22360779-4	2012	On a hydrophilic neutrally charged acrylamide-based hydrogel human intermediate (CD14++ CD16+ ), angiogenically stimulated CD163++ monocytes/macrophages (aMO2) maintained a proangiogenic and noninflammatory status for at least 14 days.	Acrylamide	35-45	CD14 molecule	Homo sapiens	81-85
22360779-4	2012	On a hydrophilic neutrally charged acrylamide-based hydrogel human intermediate (CD14++ CD16+ ), angiogenically stimulated CD163++ monocytes/macrophages (aMO2) maintained a proangiogenic and noninflammatory status for at least 14 days.	Acrylamide	35-45	Fc gamma receptor IIIa	Homo sapiens	88-92
22360779-4	2012	On a hydrophilic neutrally charged acrylamide-based hydrogel human intermediate (CD14++ CD16+ ), angiogenically stimulated CD163++ monocytes/macrophages (aMO2) maintained a proangiogenic and noninflammatory status for at least 14 days.	Acrylamide	35-45	CD163 molecule	Homo sapiens	123-128
22197712-6	2012	First, expression of the Mylpf gene involved in muscle contraction was downregulated in the spinal cord in response to acrylamide.	Acrylamide	119-129	myosin light chain, phosphorylatable, fast skeletal muscle	Rattus norvegicus	25-30
22197712-7	2012	Second, in sciatic nerves, acrylamide repressed the expression of the opioid receptor gene Oprk1 that is known to play a role in neuropathic pain regulation.	Acrylamide	27-37	opioid receptor, kappa 1	Rattus norvegicus	91-96
22197712-8	2012	Finally, in the cerebellum, acrylamide treatment caused a decrease in the expression of the nuclear receptor gene Nr4a2 that is required for development of dopaminergic neurons.	Acrylamide	28-38	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	114-119
21334869-0	2011	Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway.	Acrylamide	56-66	mitogen-activated protein kinase 8	Homo sapiens	156-159
22480170-8	2012	Acrylamide-treated mice also showed significantly higher activity of glutathione S-transferase in association with decreased levels of reduced glutathione (GSH), which may imply an enhanced rate of conjugation of AA with GSH in liver.	Acrylamide	0-10	hematopoietic prostaglandin D synthase	Mus musculus	69-94
22084934-4	2011	To address these data gaps, we incubated purified human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with acrylamide (ACR), acrolein, or methylvinyl ketone (MVK).	Acrylamide	110-120	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	56-96
22084934-4	2011	To address these data gaps, we incubated purified human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with acrylamide (ACR), acrolein, or methylvinyl ketone (MVK).	Acrylamide	110-120	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	98-103
22084934-4	2011	To address these data gaps, we incubated purified human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with acrylamide (ACR), acrolein, or methylvinyl ketone (MVK).	Acrylamide	122-125	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	56-96
22084934-4	2011	To address these data gaps, we incubated purified human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with acrylamide (ACR), acrolein, or methylvinyl ketone (MVK).	Acrylamide	122-125	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	98-103
21978862-2	2011	Acrylamide (AA), a widely distributed xenobiotic compound, is converted to its active metabolite glycidamide (GA) by the CYP2E1 enzyme.	Acrylamide	0-10	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	121-127
21855134-3	2011	By taking advantage of the polymerizable characteristics of the vinyl group, KS1 was polymerized with 2-hydroxyethyl methacrylate (HEMA) and acrylamide (AM) to form K(+) sensing films for extracellular sensing.	Acrylamide	141-151	zinc finger protein 382	Homo sapiens	77-80
21490216-6	2011	We report that BACE1 knock-out and wild-type nerves degenerated at a similar rate after axotomy and to a similar extent in the experimental neuropathies produced by administration of paclitaxel and acrylamide.	Acrylamide	198-208	beta-site APP cleaving enzyme 1	Mus musculus	15-20
22336280-14	2011	CONCLUSION: Neuronal synaptic plasticity was found in damage of nervous system induced by acrylamide in rats, which might be associated with the expression of Synapsin I.	Acrylamide	90-100	synapsin I	Rattus norvegicus	159-169
21633332-18	2011	The gst-4 reporter is also a biosensor for xenobiotic and oxidative chemicals that activate SKN-1 and can be used to detect low levels of contaminants such as acrylamide and methyl-mercury(15-16).	Acrylamide	159-169	Glutathione S-transferase 4	Caenorhabditis elegans	4-9
21633332-18	2011	The gst-4 reporter is also a biosensor for xenobiotic and oxidative chemicals that activate SKN-1 and can be used to detect low levels of contaminants such as acrylamide and methyl-mercury(15-16).	Acrylamide	159-169	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	92-97
21441395-0	2011	Acrylamide genotoxicity in young versus adult gpt delta male rats.	Acrylamide	0-10	glutamic--pyruvic transaminase	Rattus norvegicus	46-49
21402133-0	2011	Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide.	Acrylamide	70-80	epoxide hydrolase 1, microsomal	Mus musculus	31-34
21402133-0	2011	Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide.	Acrylamide	115-125	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	15-21
21402133-0	2011	Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide.	Acrylamide	115-125	epoxide hydrolase 1, microsomal	Mus musculus	31-34
21385599-0	2011	Acrylamide up-regulates cyclooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cells.	Acrylamide	0-10	prostaglandin-endoperoxide synthase 2	Mus musculus	24-40
21385599-0	2011	Acrylamide up-regulates cyclooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cells.	Acrylamide	0-10	midkine	Mus musculus	64-67
21385599-0	2011	Acrylamide up-regulates cyclooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cells.	Acrylamide	0-10	mitogen-activated protein kinase 1	Mus musculus	68-71
22214713-2	2011	On a hydrophilic, acrylamide-based hydrogel human intermediate (CD14++ CD16+) CD163++ monocytes/macrophages (aMO2) which were angiogenically stimulated, maintained a pro-angiogenic and non-inflammatory status for at least 14 days.	Acrylamide	18-28	CD163 molecule	Homo sapiens	78-83
21383158-6	2011	Transduction of Schwann cells with adenovirus AdCA5 encoding a constitutively active form of HIF-1alpha results in amelioration of acrylamide-induced axonal degeneration in an EPO-dependent manner.	Acrylamide	131-141	hypoxia inducible factor 1, alpha subunit	Mus musculus	93-103
21383158-6	2011	Transduction of Schwann cells with adenovirus AdCA5 encoding a constitutively active form of HIF-1alpha results in amelioration of acrylamide-induced axonal degeneration in an EPO-dependent manner.	Acrylamide	131-141	erythropoietin	Mus musculus	176-179
20713430-0	2011	Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells.	Acrylamide	17-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
20713430-4	2011	Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2.	Acrylamide	24-34	nitric oxide synthase 2	Homo sapiens	55-59
20713430-4	2011	Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2.	Acrylamide	24-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
20602472-5	2011	Chondrocytes were embedded in alginate and vimentin networks disrupted with acrylamide.	Acrylamide	76-86	vimentin	Homo sapiens	43-51
21438377-0	2010	[Application of solid phase extraction disk in the determination of acrylamide in tap water].	Acrylamide	68-78	nuclear RNA export factor 1	Homo sapiens	82-85
21049996-0	2010	Tuber-specific silencing of the acid invertase gene substantially lowers the acrylamide-forming potential of potato.	Acrylamide	77-87	beta-fructofuranosidase, insoluble isoenzyme 1-like	Solanum tuberosum	37-46
21049996-8	2010	Importantly, French fries from the low-invertase tubers contained up to 8-fold reduced amounts of acrylamide.	Acrylamide	98-108	beta-fructofuranosidase, insoluble isoenzyme 1-like	Solanum tuberosum	39-48
21438377-2	2010	Using this new technique along with high performance liquid chromatography (HPLC) and ultraviolet spectroscopy (UV) detection, the feasibility of SPE disk method for rapid enrichment was demonstrated in the determination of trace acrylamide in 500 mL tap water.	Acrylamide	230-240	nuclear RNA export factor 1	Homo sapiens	251-254
21438377-10	2010	The recovery for acrylamide spiked into a tap water sample was 79.	Acrylamide	17-27	nuclear RNA export factor 1	Homo sapiens	42-45
21438377-12	2010	The method is simple, fast, sensitive and suitable for the determination of acrylamide in tap water.	Acrylamide	76-86	nuclear RNA export factor 1	Homo sapiens	90-93
20835845-9	2010	Therefore, a combination of FTIR, acrylamide quenching, and ANS was used to investigate the effect of nucleotide binding on the structure of Ssa1.	Acrylamide	34-44	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	141-145
20673609-1	2010	The interactions between bisphenol A (BPA)/acrylamide (AA) and bovine serum albumin (BSA)/deoxyribonucleic acid (DNA) was investigated by the equilibrium dialysis, fluorophotometry, isothermal titration calorimetry (ITC) and circular dichroism (CD).	Acrylamide	43-53	albumin	Homo sapiens	70-83
20708675-0	2010	The inhibitory effect of acrylamide on NCAM expression in human neuroblastoma cells: involvement of CK2/Ikaros signaling pathway.	Acrylamide	25-35	neural cell adhesion molecule 1	Homo sapiens	39-43
20708675-3	2010	We examined the effect of acrylamide on NCAM expression and the mechanisms of its effect in human neuroblastoma cells.	Acrylamide	26-36	neural cell adhesion molecule 1	Homo sapiens	40-44
20708675-4	2010	Treatment with acrylamide resulted in the decrease of NCAM expression, which was reversed by CK2 inhibitor, 4,5,6,7-tetrabromobenzotriazole (TBB).	Acrylamide	15-25	neural cell adhesion molecule 1	Homo sapiens	54-58
20708675-8	2010	Small interfering RNA-mediated depletion of CK2-alpha also increased Ikaros activity in acrylamide-treated cells.	Acrylamide	88-98	casein kinase 2 alpha 2	Homo sapiens	44-53
20708675-9	2010	Overall, these data suggest that acrylamide decreases the Ikaros DNA binding activity via the CK2 pathway, resulting in a decrease of NCAM expression and provide further insight into the mechanisms underlying acrylamide actions.	Acrylamide	33-43	neural cell adhesion molecule 1	Homo sapiens	134-138
20550212-3	2010	On the basis of docking studies with EGFR hit 1s, introduction of acrylamide Michael acceptor group led to 8, which inhibited both the wild and mutant EGFR kinase and also showed antiproliferative activity in HCC827 lung cancer cell line.	Acrylamide	66-76	epidermal growth factor receptor	Homo sapiens	37-41
20427712-12	2010	Knocking-down HSP27 destroys the vimentin filamentous network, and disrupting vimentin filaments with acrylamide increases endothelial permeability.	Acrylamide	102-112	vimentin	Homo sapiens	78-86
19949857-6	2010	Cox proportional hazards analysis was applied to determine hazard ratios in quintiles of dietary acrylamide intake stratifying on estrogen receptor (ER) and progesterone receptor (PR) and smoking status.	Acrylamide	97-107	estrogen receptor 1	Homo sapiens	130-147
19949857-6	2010	Cox proportional hazards analysis was applied to determine hazard ratios in quintiles of dietary acrylamide intake stratifying on estrogen receptor (ER) and progesterone receptor (PR) and smoking status.	Acrylamide	97-107	estrogen receptor 1	Homo sapiens	149-151
20585349-7	2010	CONCLUSIONS/SIGNIFICANCE: Genetic and cellular characterization of xrep-1 mutants suggest that a large number of GSTs and other phase II enzymes induced by acrylamide are under negative regulation by XREP-1 (WDR-23), which is likely to be a functional equivalent of mammalian Keap1 and a regulator of SKN-1, a C. elegans analogue of cap-n-collar Nrf2 (nuclear factor erythroid 2-related factor 2).	Acrylamide	156-166	DDB1 and CUL4 associated factor 11	Homo sapiens	208-214
20585349-7	2010	CONCLUSIONS/SIGNIFICANCE: Genetic and cellular characterization of xrep-1 mutants suggest that a large number of GSTs and other phase II enzymes induced by acrylamide are under negative regulation by XREP-1 (WDR-23), which is likely to be a functional equivalent of mammalian Keap1 and a regulator of SKN-1, a C. elegans analogue of cap-n-collar Nrf2 (nuclear factor erythroid 2-related factor 2).	Acrylamide	156-166	kelch like ECH associated protein 1	Homo sapiens	276-281
20550212-3	2010	On the basis of docking studies with EGFR hit 1s, introduction of acrylamide Michael acceptor group led to 8, which inhibited both the wild and mutant EGFR kinase and also showed antiproliferative activity in HCC827 lung cancer cell line.	Acrylamide	66-76	epidermal growth factor receptor	Homo sapiens	151-155
19652463-0	2009	Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.	Acrylamide	122-132	HRas proto-oncogene, GTPase	Rattus norvegicus	10-15
20465949-0	2010	[Effects of tacrolimus (FK506) on heat-shock proteins 70, Bcl-2 and Bax expression in nervous tissue of acrylamide-induced rat].	Acrylamide	104-114	BCL2 associated X, apoptosis regulator	Rattus norvegicus	68-71
20151670-2	2010	They contain both a driver group, which assures target recognition, and a warhead, generally an acrylamide or propargylamide fragment that binds covalently to Cys797 within the kinase domain of EGFR.	Acrylamide	96-106	epidermal growth factor receptor	Homo sapiens	194-198
20034532-6	2010	The observed trend is likely due to a competitive effect between ethanol and acrylamide as both are substrates for cytochrome P450 2E1.	Acrylamide	77-87	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	115-134
20459032-0	2010	[Effects of acrylamide on the protein expressions of c-fos and c-jun proto-oncogenes in cell L-02].	Acrylamide	12-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-58
20459032-0	2010	[Effects of acrylamide on the protein expressions of c-fos and c-jun proto-oncogenes in cell L-02].	Acrylamide	12-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
20459032-1	2010	OBJECTIVE: To investigate the cell apoptosis and expressions of c-fos and c-jun proteins induced by acrylamide (AA) in L-02 human liver embryo cell.	Acrylamide	100-110	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-69
20459032-1	2010	OBJECTIVE: To investigate the cell apoptosis and expressions of c-fos and c-jun proteins induced by acrylamide (AA) in L-02 human liver embryo cell.	Acrylamide	100-110	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
19862503-8	2010	Acrylamide treatment increased serum alanine aminotransferase and aspartate aminotransferase activities and inhibited alkaline phosphatase activity.	Acrylamide	0-10	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	66-92
20123601-3	2010	OBJECTIVES: The aim of this study was to assess human exposure to acrylamide and glycidamide in the general U.S. population through the measurement of hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA).	Acrylamide	66-76	hemoglobin subunit gamma 1	Homo sapiens	208-212
20218802-2	2010	Genotyping the 102T/C polymorphism of the serotonin 5HT2A receptor gene and the ser9gly polymorphism in exon 1 of the dopamine D3 receptor (DRD3) gene was performed using PCR-RFLP, whereas the dopamine transporter (DAT1) gene variable number of tandem repeats (VNTR) polymorphism was investigated using PCR amplification followed by electrophoresis in an 8% acrylamide gel with a set of size markers.	Acrylamide	358-368	dopamine receptor D3	Homo sapiens	140-144
20113852-0	2010	Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE: acrylamide (CAS No.	Acrylamide	121-131	BCAR1 scaffold protein, Cas family member	Homo sapiens	133-136
19729525-3	2009	The goal of the present study was to test the hypothesis that trace acrylamide exposure might be independently associated with both reduced blood insulin and reduced insulin resistance.	Acrylamide	68-78	insulin	Homo sapiens	146-153
19729525-9	2009	CONCLUSIONS: Acrylamide is associated with reduced serum insulin levels in adults.	Acrylamide	13-23	insulin	Homo sapiens	57-64
19475399-4	2009	It also lowered caspase-3 activities and cell population in the sub-G(1) phase induced by acrylamide.	Acrylamide	90-100	caspase 3	Homo sapiens	16-25
19527682-10	2009	Fluorescence spectroscopy showed that the Trp residues of Bax-C were placed in a microenvironment more hydrophobic and less accessible to quenching by acrylamide when phosphatidylglycerol was present.	Acrylamide	151-161	BCL2 associated X, apoptosis regulator	Homo sapiens	58-63
19303701-2	2009	In this paper, functional monomer acrylamide (AM) was grafted step by step on the surface of silica gel particles, and the grafted particle PAM/SiO(2) with strong adsorption ability for TNT was formed.	Acrylamide	34-44	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	140-143
19708663-2	2009	In a search for small molecule inhibitors of LcrF, an acrylic amide series of N-hydroxybenzimidazoles was synthesized and the SAR (structure-activity relationship) was examined.	Acrylamide	54-67	LCR activator	Yersinia pestis	45-49
19620010-0	2009	Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists.	Acrylamide	61-71	C-C motif chemokine receptor 3	Homo sapiens	93-97
19620010-1	2009	Our laboratory has identified several acrylamide derivatives with potent CCR3 inhibitory activity.	Acrylamide	38-48	C-C motif chemokine receptor 3	Homo sapiens	73-77
19346293-9	2009	Analysis of acrylamide quenching experiments revealed that the binding of metal ions to p53DBD induced a structural modification of the protein and this change provided significant protection against acrylamide quenching.	Acrylamide	12-22	tumor protein p53	Homo sapiens	88-91
19594170-0	2009	Acrylamide quenching of Trp phosphorescence in liver alcohol dehydrogenase: evidence of gated quencher penetration.	Acrylamide	0-10	aldo-keto reductase family 1 member A1	Homo sapiens	53-74
19594170-3	2009	The work examines in some detail acrylamide quenching of Trp phosphorescence in a model protein (liver alcohol dehydrogenase) over an extended submillimolar to molar acrylamide concentration range.	Acrylamide	33-43	aldo-keto reductase family 1 member A1	Homo sapiens	103-124
19346293-9	2009	Analysis of acrylamide quenching experiments revealed that the binding of metal ions to p53DBD induced a structural modification of the protein and this change provided significant protection against acrylamide quenching.	Acrylamide	200-210	tumor protein p53	Homo sapiens	88-91
19361806-0	2009	Novel surface modified molecularly imprinted polymer using acryloyl-beta-cyclodextrin and acrylamide as monomers for selective recognition of lysozyme in aqueous solution.	Acrylamide	90-100	lysozyme	Homo sapiens	142-150
19403668-4	2009	Chemical disruption of the vimentin network with acrylamide, intermediate filament bundling in cells from a patient with giant axonal neuropathy, and absence of vimentin in fibroblasts from vimentin(-/-) mice severely reduced entry of either strain.	Acrylamide	49-59	vimentin	Homo sapiens	27-35
19123476-9	2009	In mice dosed on PNDs 1-8, 0.70 mmol glycidamide caused extensive mortality; each of the other treatments increased the Tk mutant frequency, whereas acrylamide increased the Hprt mutant frequency.	Acrylamide	149-159	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	174-178
19678553-0	2009	Alkylation of adenosine deaminase and thioredoxin by acrylamide in human cell cultures.	Acrylamide	53-63	thioredoxin	Homo sapiens	38-49
19778218-0	2009	Long-term exposure to various types of dietary fat modulates acrylamide-induced preneoplastic lesions of colon mucosa through Wnt/beta-catenin signaling in rats.	Acrylamide	61-71	Wnt family member 2	Rattus norvegicus	126-129
19778218-0	2009	Long-term exposure to various types of dietary fat modulates acrylamide-induced preneoplastic lesions of colon mucosa through Wnt/beta-catenin signaling in rats.	Acrylamide	61-71	catenin beta 1	Rattus norvegicus	130-142
19678553-0	2009	Alkylation of adenosine deaminase and thioredoxin by acrylamide in human cell cultures.	Acrylamide	53-63	adenosine deaminase	Homo sapiens	14-33
19678553-6	2009	Here we identify two novel acrylamide target proteins in human cell cultures (Jurkat, HepG2 and Caco-2), adenosine deaminase and thioredoxin.	Acrylamide	27-37	adenosine deaminase	Homo sapiens	105-124
19678553-6	2009	Here we identify two novel acrylamide target proteins in human cell cultures (Jurkat, HepG2 and Caco-2), adenosine deaminase and thioredoxin.	Acrylamide	27-37	thioredoxin	Homo sapiens	129-140
19344517-12	2009	Two spots analyzed from 2-D focusing/phoresis acrylamide gel showed the correct amino acid sequence of human IGF-1 and the S. aureus Z-tag.	Acrylamide	46-56	insulin like growth factor 1	Homo sapiens	109-114
19233635-2	2009	We have synthesized MIP films (co-polymers of acrylamide and different acrylic acid-based cross-linkers) with specific binding sites for cytochrome c, which were imprinted in the bulk or in the surface.	Acrylamide	46-56	cytochrome c, somatic	Homo sapiens	137-149
19750022-0	2009	Apoptosis induced by acrylamide is suppressed in a 21.5% fat diet through caspase-3-independent pathway in mice testis.	Acrylamide	21-31	caspase 3	Mus musculus	74-83
19115253-9	2009	Additionally, phosphorylated hSGLT1 demonstrated a reduction in tryptophan fluorescence intensity and a higher quenching by the hydrophilic Trp quencher acrylamide, particularly in the presence of D-glucose.	Acrylamide	153-163	solute carrier family 5 member 1	Homo sapiens	29-35
19378044-3	2009	When the Ro 60-coated nitrocellulose was laid over the surface of the IEF gel, the antibodies present on the surface of the acrylamide gel bound the Ro antigen on the nitrocellulose.	Acrylamide	124-134	Ro60, Y RNA binding protein	Homo sapiens	9-14
19061912-3	2009	We studied the inhibitory effects of acrylamide on the brain creatine kinase (CK-BB).	Acrylamide	37-47	creatine kinase B	Homo sapiens	78-83
19061912-4	2009	We found that CK-BB was kinetically inactivated by acrylamide accompanied by the disruption of the hydrophobic surface.	Acrylamide	51-61	creatine kinase B	Homo sapiens	14-19
19061912-5	2009	Acrylamide mainly interacted with the thiol (-SH) residue of CK-BB and resulted in alkylation.	Acrylamide	0-10	creatine kinase B	Homo sapiens	61-66
19061912-6	2009	A computational docking simulation supported that acrylamide directly bound to the active site of CK-BB where cysteine and glycine residues interacted mainly.	Acrylamide	50-60	creatine kinase B	Homo sapiens	98-103
19015201-4	2009	The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors.	Acrylamide	60-70	estrogen receptor 1	Homo sapiens	188-190
19015201-4	2009	The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors.	Acrylamide	60-70	progesterone receptor	Homo sapiens	191-193
19015201-4	2009	The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors.	Acrylamide	60-70	estrogen receptor 1	Homo sapiens	233-235
19015201-4	2009	The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors.	Acrylamide	60-70	progesterone receptor	Homo sapiens	236-238
19015201-4	2009	The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors.	Acrylamide	60-70	estrogen receptor 1	Homo sapiens	233-235
19015201-4	2009	The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors.	Acrylamide	60-70	progesterone receptor	Homo sapiens	236-238
19190172-0	2009	In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.	Acrylamide	79-89	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	16-35
19190172-0	2009	In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.	Acrylamide	79-89	glutathione S-transferase kappa 1	Homo sapiens	40-65
19190172-9	2009	The changes in acrylamide toxicokinetics upon CYP2E1 blockade provide evidence that CYP2E1 is a major but not the only enzyme mediating acrylamide epoxidation in vivo to glycidamide in humans.	Acrylamide	15-25	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-52
19190172-9	2009	The changes in acrylamide toxicokinetics upon CYP2E1 blockade provide evidence that CYP2E1 is a major but not the only enzyme mediating acrylamide epoxidation in vivo to glycidamide in humans.	Acrylamide	15-25	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	84-90
19190172-9	2009	The changes in acrylamide toxicokinetics upon CYP2E1 blockade provide evidence that CYP2E1 is a major but not the only enzyme mediating acrylamide epoxidation in vivo to glycidamide in humans.	Acrylamide	136-146	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	84-90