PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19229106-5	2009	Here, we report the synthesis and properties of Gamitrinibs, a class of small molecules designed to selectively target Hsp90 in human tumor mitochondria.	gamitrinibs	48-59	heat shock protein 90 alpha family class A member 1	Homo sapiens	119-124
20876793-0	2010	Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer.	gamitrinibs	87-98	heat shock protein, 2	Mus musculus	69-74
20876793-1	2010	PURPOSE: This study aimed to characterize the preclinical activity of the first class of combinatorial, mitochondria-targeted, small molecule heat shock protein-90 (Hsp90) inhibitors, gamitrinibs, in models of hormone-refractory, drug-resistant, localized, and bone metastatic prostate cancer in vivo.	gamitrinibs	184-195	heat shock protein, 2	Mus musculus	142-163
20876793-1	2010	PURPOSE: This study aimed to characterize the preclinical activity of the first class of combinatorial, mitochondria-targeted, small molecule heat shock protein-90 (Hsp90) inhibitors, gamitrinibs, in models of hormone-refractory, drug-resistant, localized, and bone metastatic prostate cancer in vivo.	gamitrinibs	184-195	heat shock protein, 2	Mus musculus	165-170
20876793-7	2010	Mechanistically, gamitrinibs, but not 17-AAG, induced acute mitochondrial dysfunction in prostate cancer cells with loss of organelle membrane potential, release of cytochrome c, and caspase activity, independently of proapoptotic Bcl-2 proteins Bax and Bak.	gamitrinibs	17-28	B cell leukemia/lymphoma 2	Mus musculus	231-236
20876793-7	2010	Mechanistically, gamitrinibs, but not 17-AAG, induced acute mitochondrial dysfunction in prostate cancer cells with loss of organelle membrane potential, release of cytochrome c, and caspase activity, independently of proapoptotic Bcl-2 proteins Bax and Bak.	gamitrinibs	17-28	BCL2-associated X protein	Mus musculus	246-249
20876793-7	2010	Mechanistically, gamitrinibs, but not 17-AAG, induced acute mitochondrial dysfunction in prostate cancer cells with loss of organelle membrane potential, release of cytochrome c, and caspase activity, independently of proapoptotic Bcl-2 proteins Bax and Bak.	gamitrinibs	17-28	BCL2-antagonist/killer 1	Mus musculus	254-257
19306500-5	2009	report the synthesis of Gamitrinibs, which target mitochondrially localized HSP90, specifically killing human cancer cell lines, and provide a fresh approach for cancer treatment.	gamitrinibs	24-35	heat shock protein 90 alpha family class A member 1	Homo sapiens	76-81
19948822-5	2010	Targeting TRAP-1 with a novel class of mitochondria-directed Hsp90 inhibitors, ie, Gamitrinibs, caused rapid and complete killing of androgen-dependent or -independent prostate cancer, but not BPH-1 cells, whereas reintroduction of TRAP-1 in BPH-1 cells conferred sensitivity to Gamitrinib-induced cell death.	gamitrinibs	83-94	TNF receptor associated protein 1	Homo sapiens	10-16
19948822-5	2010	Targeting TRAP-1 with a novel class of mitochondria-directed Hsp90 inhibitors, ie, Gamitrinibs, caused rapid and complete killing of androgen-dependent or -independent prostate cancer, but not BPH-1 cells, whereas reintroduction of TRAP-1 in BPH-1 cells conferred sensitivity to Gamitrinib-induced cell death.	gamitrinibs	83-94	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-66
19948822-5	2010	Targeting TRAP-1 with a novel class of mitochondria-directed Hsp90 inhibitors, ie, Gamitrinibs, caused rapid and complete killing of androgen-dependent or -independent prostate cancer, but not BPH-1 cells, whereas reintroduction of TRAP-1 in BPH-1 cells conferred sensitivity to Gamitrinib-induced cell death.	gamitrinibs	83-94	TNF receptor associated protein 1	Homo sapiens	232-238
19229106-6	2009	Gamitrinibs were shown to accumulate in the mitochondria of human tumor cell lines and to inhibit Hsp90 activity by acting as ATPase antagonists.	gamitrinibs	0-11	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103