PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20723590-3	2010	MATERIALS AND METHODS: The inhibitory activities of 1-O-MFF were examined by melanin synthesis, tyrosinase activity assay, Western blot and flow cytometric analyses in B16F0 mouse melanoma cells.	methylfructoside	52-59	tyrosinase	Mus musculus	96-106
20723590-4	2010	RESULTS: 1-O-MFF significantly inhibited both melanin synthesis and tyrosinase activity in a concentration-dependent manner, and reduced the expression of melanogenic proteins including microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein-1.	methylfructoside	9-16	tyrosinase	Mus musculus	68-78
20723590-4	2010	RESULTS: 1-O-MFF significantly inhibited both melanin synthesis and tyrosinase activity in a concentration-dependent manner, and reduced the expression of melanogenic proteins including microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein-1.	methylfructoside	9-16	melanogenesis associated transcription factor	Mus musculus	155-232
20723590-4	2010	RESULTS: 1-O-MFF significantly inhibited both melanin synthesis and tyrosinase activity in a concentration-dependent manner, and reduced the expression of melanogenic proteins including microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein-1.	methylfructoside	9-16	melanogenesis associated transcription factor	Mus musculus	234-238
20723590-4	2010	RESULTS: 1-O-MFF significantly inhibited both melanin synthesis and tyrosinase activity in a concentration-dependent manner, and reduced the expression of melanogenic proteins including microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein-1.	methylfructoside	9-16	tyrosinase	Mus musculus	241-251
20723590-4	2010	RESULTS: 1-O-MFF significantly inhibited both melanin synthesis and tyrosinase activity in a concentration-dependent manner, and reduced the expression of melanogenic proteins including microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein-1.	methylfructoside	9-16	tyrosinase	Mus musculus	241-251
20723590-5	2010	1-O-MFF phosphorylated and activated melanogenesis inhibitory proteins such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and Akt.	methylfructoside	0-7	midkine	Mus musculus	79-118
20723590-5	2010	1-O-MFF phosphorylated and activated melanogenesis inhibitory proteins such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and Akt.	methylfructoside	0-7	midkine	Mus musculus	120-123
20723590-5	2010	1-O-MFF phosphorylated and activated melanogenesis inhibitory proteins such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and Akt.	methylfructoside	0-7	mitogen-activated protein kinase 1	Mus musculus	164-167
20723590-5	2010	1-O-MFF phosphorylated and activated melanogenesis inhibitory proteins such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and Akt.	methylfructoside	0-7	thymoma viral proto-oncogene 1	Mus musculus	173-176
20723590-6	2010	Flow cytometry confirmed that 1-O-MFF phosphorylated ERK and Akt proteins and recovered partially phosphorylated forms in cells treated with the MEK/ERK inhibitor compound PD98059 and the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor compound LY294002.	methylfructoside	30-37	mitogen-activated protein kinase 1	Mus musculus	53-56
20723590-6	2010	Flow cytometry confirmed that 1-O-MFF phosphorylated ERK and Akt proteins and recovered partially phosphorylated forms in cells treated with the MEK/ERK inhibitor compound PD98059 and the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor compound LY294002.	methylfructoside	30-37	thymoma viral proto-oncogene 1	Mus musculus	61-64
20723590-6	2010	Flow cytometry confirmed that 1-O-MFF phosphorylated ERK and Akt proteins and recovered partially phosphorylated forms in cells treated with the MEK/ERK inhibitor compound PD98059 and the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor compound LY294002.	methylfructoside	30-37	midkine	Mus musculus	145-148
20723590-6	2010	Flow cytometry confirmed that 1-O-MFF phosphorylated ERK and Akt proteins and recovered partially phosphorylated forms in cells treated with the MEK/ERK inhibitor compound PD98059 and the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor compound LY294002.	methylfructoside	30-37	mitogen-activated protein kinase 1	Mus musculus	149-152
20723590-6	2010	Flow cytometry confirmed that 1-O-MFF phosphorylated ERK and Akt proteins and recovered partially phosphorylated forms in cells treated with the MEK/ERK inhibitor compound PD98059 and the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor compound LY294002.	methylfructoside	30-37	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	188-217
20723590-6	2010	Flow cytometry confirmed that 1-O-MFF phosphorylated ERK and Akt proteins and recovered partially phosphorylated forms in cells treated with the MEK/ERK inhibitor compound PD98059 and the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor compound LY294002.	methylfructoside	30-37	thymoma viral proto-oncogene 1	Mus musculus	225-228
20723590-7	2010	CONCLUSIONS: The suppressive effects of 1-O-MFF on melanogenesis may involve down-regulation of MITF and its downstream signal pathway via the activation of MEK/ERK or PI3K/Akt.	methylfructoside	40-47	melanogenesis associated transcription factor	Mus musculus	96-100
20723590-7	2010	CONCLUSIONS: The suppressive effects of 1-O-MFF on melanogenesis may involve down-regulation of MITF and its downstream signal pathway via the activation of MEK/ERK or PI3K/Akt.	methylfructoside	40-47	midkine	Mus musculus	157-160
20723590-7	2010	CONCLUSIONS: The suppressive effects of 1-O-MFF on melanogenesis may involve down-regulation of MITF and its downstream signal pathway via the activation of MEK/ERK or PI3K/Akt.	methylfructoside	40-47	mitogen-activated protein kinase 1	Mus musculus	161-164
20723590-7	2010	CONCLUSIONS: The suppressive effects of 1-O-MFF on melanogenesis may involve down-regulation of MITF and its downstream signal pathway via the activation of MEK/ERK or PI3K/Akt.	methylfructoside	40-47	thymoma viral proto-oncogene 1	Mus musculus	173-176