PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 26876578-5 2016 Two p53 binding sites were mapped in the STAT5A gene and named PBS1 and PBS2; these sites were sufficient to confer p53 responsiveness in a luciferase reporter gene. pbs2 72-76 tumor protein p53 Homo sapiens 4-7 810487-10 1975 We propose that infection at high pH prevents the PBS2-induced dUTPase inhibitor from blocking the B. subtilis dUTPase activity, thereby allowing the degradation of dUTP and the synthesis of dTTP (both of which are DNA polymerase substrates), so that thymine replaces some of the uracil normally found in PBS2 DNA. pbs2 50-54 Deoxyuridine triphosphatase Drosophila melanogaster 63-70 810487-10 1975 We propose that infection at high pH prevents the PBS2-induced dUTPase inhibitor from blocking the B. subtilis dUTPase activity, thereby allowing the degradation of dUTP and the synthesis of dTTP (both of which are DNA polymerase substrates), so that thymine replaces some of the uracil normally found in PBS2 DNA. pbs2 50-54 Deoxyuridine triphosphatase Drosophila melanogaster 111-118 810487-10 1975 We propose that infection at high pH prevents the PBS2-induced dUTPase inhibitor from blocking the B. subtilis dUTPase activity, thereby allowing the degradation of dUTP and the synthesis of dTTP (both of which are DNA polymerase substrates), so that thymine replaces some of the uracil normally found in PBS2 DNA. pbs2 305-309 Deoxyuridine triphosphatase Drosophila melanogaster 63-70 810487-10 1975 We propose that infection at high pH prevents the PBS2-induced dUTPase inhibitor from blocking the B. subtilis dUTPase activity, thereby allowing the degradation of dUTP and the synthesis of dTTP (both of which are DNA polymerase substrates), so that thymine replaces some of the uracil normally found in PBS2 DNA. pbs2 305-309 Deoxyuridine triphosphatase Drosophila melanogaster 111-118 28076898-1 2017 High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. pbs2 213-217 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 129-133 28076898-1 2017 High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. pbs2 213-217 mitogen-activated protein kinase kinase kinase SSK2 Saccharomyces cerevisiae S288C 168-172 28076898-1 2017 High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. pbs2 213-217 mitogen-activated protein kinase kinase kinase SSK22 Saccharomyces cerevisiae S288C 173-178 28076898-1 2017 High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. pbs2 213-217 mitogen-activated protein kinase kinase kinase STE11 Saccharomyces cerevisiae S288C 183-188 27413009-6 2016 We show that these variants are phosphorylated at their activation loop in mkk1 mkk2 and mkk1 mkk2 pbs2 ste7 cells, suggesting that they autophosphorylate. pbs2 100-104 mitogen-activated protein kinase kinase MKK1 Saccharomyces cerevisiae S288C 75-79 27413009-6 2016 We show that these variants are phosphorylated at their activation loop in mkk1 mkk2 and mkk1 mkk2 pbs2 ste7 cells, suggesting that they autophosphorylate. pbs2 100-104 mitogen-activated protein kinase kinase MKK1 Saccharomyces cerevisiae S288C 90-94 27413009-6 2016 We show that these variants are phosphorylated at their activation loop in mkk1 mkk2 and mkk1 mkk2 pbs2 ste7 cells, suggesting that they autophosphorylate. pbs2 100-104 putative mitogen-activated protein kinase kinase MKK2 Saccharomyces cerevisiae S288C 95-99 26876578-5 2016 Two p53 binding sites were mapped in the STAT5A gene and named PBS1 and PBS2; these sites were sufficient to confer p53 responsiveness in a luciferase reporter gene. pbs2 72-76 signal transducer and activator of transcription 5A Homo sapiens 41-47 26876578-5 2016 Two p53 binding sites were mapped in the STAT5A gene and named PBS1 and PBS2; these sites were sufficient to confer p53 responsiveness in a luciferase reporter gene. pbs2 72-76 tumor protein p53 Homo sapiens 116-119 26876578-6 2016 Chromatin immunoprecipitation experiments revealed that PBS2 has constitutive p53 bound to it, while p53 binding to PBS1 required DNA damage. pbs2 56-60 tumor protein p53 Homo sapiens 78-81 25492886-7 2014 We observed a pheromone-induced down-regulation of Hog1 phosphorylation due to Gpd1, Ste20, Ptp2, Pbs2, and Ptc1. pbs2 98-102 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 51-55 22984552-4 2012 Here we show however, that the yeast MAPK Hog1, known to be activated by the MAP2K Pbs2, is activated in pbs2Delta cells via an autophosphorylation activity that is induced by osmotic pressure. pbs2 83-87 methionine aminopeptidase Saccharomyces cerevisiae S288C 77-81 15773992-5 2005 Moreover, hyperactivation of Hog1p by deletion of protein phosphatase PTP2 enhanced the response, while blocking the pathway by deletion of the MAPKK PBS2 had a negative effect. pbs2 150-154 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 29-34 12519763-9 2003 The proteins binding to PBS2 and PBS4 were identified as the Sp1/Sp3 family of transcription factors and YY1, respectively. pbs2 24-28 trans-acting transcription factor 3 Mus musculus 65-68 12519763-9 2003 The proteins binding to PBS2 and PBS4 were identified as the Sp1/Sp3 family of transcription factors and YY1, respectively. pbs2 24-28 YY1 transcription factor Mus musculus 105-108 12006652-9 2002 The PKL amino terminus, containing the PIX-binding site, but lacking paxillin-binding subdomain 2 (PBS2), was unable to localize to focal adhesions and also abrogated PAK localization. pbs2 99-103 GIT ArfGAP 2 Homo sapiens 4-7 12006652-12 2002 These results suggest a GTP-Cdc42/GTP-Rac triggered multistep activation cascade leading to the stimulation of the adaptor function of PAK, which through interaction with PIX provokes a functional PKL PBS2-paxillin LD4 association and consequent recruitment to focal adhesions. pbs2 201-205 cell division cycle 42 Homo sapiens 28-33 12006652-12 2002 These results suggest a GTP-Cdc42/GTP-Rac triggered multistep activation cascade leading to the stimulation of the adaptor function of PAK, which through interaction with PIX provokes a functional PKL PBS2-paxillin LD4 association and consequent recruitment to focal adhesions. pbs2 201-205 GIT ArfGAP 2 Homo sapiens 197-200 12006652-12 2002 These results suggest a GTP-Cdc42/GTP-Rac triggered multistep activation cascade leading to the stimulation of the adaptor function of PAK, which through interaction with PIX provokes a functional PKL PBS2-paxillin LD4 association and consequent recruitment to focal adhesions. pbs2 201-205 paxillin Homo sapiens 206-214 11126771-3 2000 Atlantic cUNG is inhibited by the specific UNG inhibitor (Ugi) from the Bacillus subtilis bacteriophage (PBS2), and has a 2-fold higher activity for single-stranded DNA than for double-stranded DNA. pbs2 105-109 uracil DNA glycosylase Homo sapiens 10-13 7493921-5 1995 In contrast, wild-type CSBP2 is constitutively active but dependent on the upstream kinase, Pbs2. pbs2 92-96 mitogen-activated protein kinase 14 Homo sapiens 23-28 3011743-6 1986 lon strains carrying pZAQ could stably maintain a multicopy plasmid carrying sulA (pBS2), which cannot otherwise be introduced into lon mutants. pbs2 83-87 putative ATP-dependent Lon protease Escherichia coli 0-3