PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19494047-8	2009	A peak in 8-OHdG index was observed in testicular fragments treated with 100 microM arsenic and hCG consistent with the TUNEL results.	8-ohdg	10-16	chorionic gonadotropin subunit beta 5	Homo sapiens	96-99
19250857-4	2009	Enhanced expression of CYP1A1 and CYP1B1 isoforms in both human and hamster oral tumours was associated with significantly increased expression of 8-hydroxy 2-deoxyguanosine (8-OHdG) indicating oxidative DNA damage.	8-ohdg	147-173	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	23-29
19450981-0	2009	Selection of a DNA aptamer that binds 8-OHdG using GMP-agarose.	8-ohdg	38-44	5'-nucleotidase, cytosolic II	Homo sapiens	51-54
19450981-3	2009	Therefore, a DNA aptamer binding to 8-OHdG was selected using GMP-agarose as an analogue from a library of about 4(60) random ssDNA sources.	8-ohdg	36-42	5'-nucleotidase, cytosolic II	Homo sapiens	62-65
19250857-4	2009	Enhanced expression of CYP1A1 and CYP1B1 isoforms in both human and hamster oral tumours was associated with significantly increased expression of 8-hydroxy 2-deoxyguanosine (8-OHdG) indicating oxidative DNA damage.	8-ohdg	147-173	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40
19250857-4	2009	Enhanced expression of CYP1A1 and CYP1B1 isoforms in both human and hamster oral tumours was associated with significantly increased expression of 8-hydroxy 2-deoxyguanosine (8-OHdG) indicating oxidative DNA damage.	8-ohdg	175-181	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	23-29
19268524-6	2009	APE1/Ref-1 haploinsufficiency results in a significant decline in the repair of oxidized bases (e.g., 8-OHdG), whereas removal of uracil is increased in liver nuclear extracts of mice using an in vitro BER assay.	8-ohdg	102-108	apurinic/apyrimidinic endonuclease 1	Mus musculus	5-10
19250857-4	2009	Enhanced expression of CYP1A1 and CYP1B1 isoforms in both human and hamster oral tumours was associated with significantly increased expression of 8-hydroxy 2-deoxyguanosine (8-OHdG) indicating oxidative DNA damage.	8-ohdg	175-181	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40
19374330-3	2009	DA, its L-dihydroxyphenylalanine (L-DOPA), precursor, and its dihydroxyphenylacetic acid (DOPAC) metabolite were excellent PHS-1 substrates, resulting in PHS-1-dependent ROS formation that initiated oxidative DNA damage, selectively quantified as 8-oxo-2"-deoxyguanosine.	8-ohdg	247-270	prostaglandin-endoperoxide synthase 1	Bos taurus	123-128
19272447-7	2009	The level of urinary PRL (21.6+/-10.6 micromol/mol of creatinine) significantly correlated with the other oxidative stress markers, 8-oxo-deoxyguanosine, dityrosine, and isoprostanes.	8-ohdg	132-152	prolactin	Homo sapiens	21-24
19146996-11	2009	On the other hand, urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, was significantly elevated in diabetic WT and attenuated in diabetic TRX-Tg.	8-ohdg	40-63	thioredoxin 1	Mus musculus	177-180
19146996-11	2009	On the other hand, urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, was significantly elevated in diabetic WT and attenuated in diabetic TRX-Tg.	8-ohdg	65-71	thioredoxin 1	Mus musculus	177-180
19309085-14	2009	At low levels of oxidative DNA damage, there was an excellent correlation between a comet assay that measured DNA single strand breaks (SSBs) after treatment with human 8-oxo-guanine glycosylase-1 (hOGG1) when compared with 8-oxo-dGuo in the DNA as measured by the stable isotope dilution LC-MRM/MS method.	8-ohdg	224-234	8-oxoguanine DNA glycosylase	Homo sapiens	198-203
19309085-17	2009	In keeping with this concept, inhibition of catechol-O-methyl transferase (COMT)-mediated detoxification of B[a]P-7,8-catechol with Ro 410961 caused increased 8-oxo-dGuo formation in the H358 cell DNA.	8-ohdg	159-169	catechol-O-methyltransferase	Homo sapiens	44-73
19309085-17	2009	In keeping with this concept, inhibition of catechol-O-methyl transferase (COMT)-mediated detoxification of B[a]P-7,8-catechol with Ro 410961 caused increased 8-oxo-dGuo formation in the H358 cell DNA.	8-ohdg	159-169	catechol-O-methyltransferase	Homo sapiens	75-79
19374330-3	2009	DA, its L-dihydroxyphenylalanine (L-DOPA), precursor, and its dihydroxyphenylacetic acid (DOPAC) metabolite were excellent PHS-1 substrates, resulting in PHS-1-dependent ROS formation that initiated oxidative DNA damage, selectively quantified as 8-oxo-2"-deoxyguanosine.	8-ohdg	247-270	prostaglandin-endoperoxide synthase 1	Bos taurus	154-159
19421389-8	2009	Additionally, there were significant negative correlations between salivary levels of 8-OHdG and both salivary SOD and GPx activities as well as between salivary levels of MDA and both salivary SOD and GPx activities (P<.001).	8-ohdg	86-92	superoxide dismutase 1	Homo sapiens	111-114
19407952-10	2009	Ginsenoside Rb1 also inhibited the heme oxygenase (HO-1) and 8-OHdG, two markers of oxidative stress (P<0.05).	8-ohdg	61-67	RB transcriptional corepressor 1	Rattus norvegicus	12-15
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	8-ohdg	78-85	8-oxoguanine DNA glycosylase	Homo sapiens	20-48
19399402-7	2009	It is concluded that HBx gene may inhibit the expression of DNA repair enzyme hMYHalpha mRNA to impair the ability to repair the intracellular DNA oxidative damage, to increase the oxidative DNA-adduct 8-OHdG and to affect the nucleotide excision repair function, thus participate in the occurrence and development of hepatocellular carcinoma.	8-ohdg	202-208	myosin heavy chain 1	Homo sapiens	78-87
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	8-ohdg	78-85	8-oxoguanine DNA glycosylase	Homo sapiens	50-55
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	8-ohdg	78-85	8-oxoguanine DNA glycosylase	Homo sapiens	241-246
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	8-ohdg	221-228	8-oxoguanine DNA glycosylase	Homo sapiens	20-48
19193190-6	2009	Moreover, the human 8-oxoguanine-DNA glycosylase (hOGG1)-mediated cleavage of 8-oxodG was compromised considerably by the presence of a neighboring 5" Tg, whereas the presence of Tg as the adjacent 3" nucleoside enhanced 8-oxodG cleavage by hOGG1.	8-ohdg	221-228	8-oxoguanine DNA glycosylase	Homo sapiens	50-55
19056730-3	2009	Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in base excision repair, a process that repairs 8-OHdG lesions.	8-ohdg	99-105	poly(ADP-ribose) polymerase 1	Homo sapiens	0-29
19056730-3	2009	Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in base excision repair, a process that repairs 8-OHdG lesions.	8-ohdg	99-105	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
19056730-5	2009	Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage.	8-ohdg	142-148	poly(ADP-ribose) polymerase 1	Homo sapiens	14-20
19056730-5	2009	Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage.	8-ohdg	142-148	poly(ADP-ribose) polymerase 1	Homo sapiens	88-94
19056730-5	2009	Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage.	8-ohdg	142-148	poly(ADP-ribose) polymerase 1	Homo sapiens	88-94
18952710-5	2009	Relative to wild-type mice, MIF(-/-) mice also show significantly lower vascular endothelial growth factor (VEGF) concentrations in whole skin and significantly lower 8-oxo-dG adduct concentrations in epidermal DNA following UVB exposure.	8-ohdg	167-175	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	28-31
19462668-5	2009	The addition of a copper chelator caused a decrease in the frequency of 8-oxodGuo and 1,N2-epsilondGuo, indicating the participation of copper ions lost from SOD1 active sites.	8-ohdg	72-81	superoxide dismutase [Cu-Zn]	Bos taurus	158-162
19071211-3	2009	Increased 8-OHdG staining, a marker of oxidative stress, was observed in brain sections from mice deficient in the p62 gene compared to control.	8-ohdg	10-16	nucleoporin 62	Mus musculus	115-118
19182371-5	2009	An increase in the hepatic bile acid concentration in Fxr-null mice fed a cholic acid (CA) diet resulted in an increase in the hepatic levels of hydroperoxides, TBARS and 8OHdG, whereas a decrease in the hepatic concentration in mice fed a diet containing ME3738 (22beta-methoxyolean-12-ene-3beta,24(4beta)-diol) resulted in a decrease in these oxidative stress marker levels.	8-ohdg	171-176	nuclear receptor subfamily 1, group H, member 4	Mus musculus	54-57
19190144-6	2009	Logistic regression analysis also showed that hepatic iron deposit and insulin resistance were independent variables associated with elevated hepatic 8-oxodG.	8-ohdg	150-157	insulin	Homo sapiens	71-78
19204871-4	2009	Moreover, urinary 8-OHdG was positively associated with age (p <0.05) and negatively associated with BMI (p <0.05) and fasting insulin (p <0.001).	8-ohdg	18-24	insulin	Homo sapiens	133-140
19358003-3	2009	It is reported that 8-oxodG was able to effectively inhibit Rac and the Rac-associated functions of MpMphi.	8-ohdg	20-27	thymoma viral proto-oncogene 1	Mus musculus	60-63
19056870-3	2009	This study tested the association of a common GST M1 gene polymorphism [GST M1(-)], known to produce a dysfunctional enzyme, with levels of 8-OHdG in peripheral blood leukocytes and all-cause mortality among MHD patients.	8-ohdg	140-146	glutathione S-transferase mu 1	Homo sapiens	46-52
19056870-3	2009	This study tested the association of a common GST M1 gene polymorphism [GST M1(-)], known to produce a dysfunctional enzyme, with levels of 8-OHdG in peripheral blood leukocytes and all-cause mortality among MHD patients.	8-ohdg	140-146	glutathione S-transferase mu 1	Homo sapiens	72-78
19056870-5	2009	The GST M1(-) genotype was associated with significantly higher levels of leukocyte 8-OHdG compared with the GST M1(+) genotype, even after adjustment for potential confounders (P < 0.001).	8-ohdg	84-90	glutathione S-transferase mu 1	Homo sapiens	4-10
19056870-6	2009	Moreover, GST M1(-) patients who also had a common polymorphism in the DNA repair enzyme 8-oxoguanine DNA glycosylase 1 or who underwent dialysis with a bioincompatible cellulose membrane had the highest median levels of leukocyte 8-OHdG.	8-ohdg	231-237	glutathione S-transferase mu 1	Homo sapiens	10-16
19028566-6	2009	AOPP increased continuously from 4 h (+69%) to 12 h (+216%) of hypoxic exposure while 8-OHdG increased after 6 h (+78%) and remained elevated until 12 h. During the "acute" increase phase of HIF-1 alpha (between 0 and 2 h), 8-OHdG was positively correlated with HIF-1 alpha (r=0.55).	8-ohdg	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-202
19028566-6	2009	AOPP increased continuously from 4 h (+69%) to 12 h (+216%) of hypoxic exposure while 8-OHdG increased after 6 h (+78%) and remained elevated until 12 h. During the "acute" increase phase of HIF-1 alpha (between 0 and 2 h), 8-OHdG was positively correlated with HIF-1 alpha (r=0.55).	8-ohdg	224-230	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-202
19358003-0	2009	Inhibition of Rac and Rac-linked functions by 8-oxo-2"-deoxyguanosine in murine macrophages.	8-ohdg	46-69	thymoma viral proto-oncogene 1	Mus musculus	14-17
19358003-0	2009	Inhibition of Rac and Rac-linked functions by 8-oxo-2"-deoxyguanosine in murine macrophages.	8-ohdg	46-69	thymoma viral proto-oncogene 1	Mus musculus	22-25
19081768-7	2009	MIF was also associated with 8-hydroxy-2-deoxyguanosine (8-OH-dG) levels (rho = 0.26; P = 0.001), a marker of oxidative stress, and ICAM-1 levels (rho = 0.14; P = 0.02), a marker of endothelial activation.	8-ohdg	29-55	macrophage migration inhibitory factor	Homo sapiens	0-3
19081768-7	2009	MIF was also associated with 8-hydroxy-2-deoxyguanosine (8-OH-dG) levels (rho = 0.26; P = 0.001), a marker of oxidative stress, and ICAM-1 levels (rho = 0.14; P = 0.02), a marker of endothelial activation.	8-ohdg	57-64	macrophage migration inhibitory factor	Homo sapiens	0-3
19066606-6	2009	Double immunofluorescence using 8-oxo-dG and manganese superoxide dismutase (MnSOD) antibodies localised cytoplasmic 8-oxo-dG.	8-ohdg	117-125	superoxide dismutase 2	Homo sapiens	45-75
19066606-6	2009	Double immunofluorescence using 8-oxo-dG and manganese superoxide dismutase (MnSOD) antibodies localised cytoplasmic 8-oxo-dG.	8-ohdg	117-125	superoxide dismutase 2	Homo sapiens	77-82
19358003-3	2009	It is reported that 8-oxodG was able to effectively inhibit Rac and the Rac-associated functions of MpMphi.	8-ohdg	20-27	thymoma viral proto-oncogene 1	Mus musculus	72-75
19072863-9	2009	In TRAMP mice, urinary 8-oxodG levels were elevated with increasing age (p < 0.0001) but not changed by the presence of prostate tumours.	8-ohdg	23-30	tumor necrosis factor receptor superfamily, member 25	Mus musculus	3-8
18793663-3	2008	8-Hydroxy-2"-deoxyguanosine (8-OHdG) is one of the most abundant oxidative DNA lesions resulting from ROS, and 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase/lyase enzyme, plays a key role in the removal of 8-OHdG adducts.	8-ohdg	0-27	8-oxoguanine DNA glycosylase	Rattus norvegicus	111-137
18793759-4	2008	Using the hOGG1 comet assay, we herein demonstrate high levels of 8-oxodG and alkali-labile sites (ALS) in cells treated with biologically relevant doses of 6-TG, or Aza, plus UVA.	8-ohdg	66-73	8-oxoguanine DNA glycosylase	Homo sapiens	10-15
18793663-3	2008	8-Hydroxy-2"-deoxyguanosine (8-OHdG) is one of the most abundant oxidative DNA lesions resulting from ROS, and 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase/lyase enzyme, plays a key role in the removal of 8-OHdG adducts.	8-ohdg	222-228	8-oxoguanine DNA glycosylase	Rattus norvegicus	111-137
19064361-0	2008	The association of OGG1 Ser326Cys polymorphism and urinary 8-OHdG levels with lung cancer susceptibility: a hospital-based case-control study in Turkey.	8-ohdg	59-65	N-glycosylase/DNA lyase	Meleagris gallopavo	19-23
19138035-5	2008	8-Oxo-dG is removed from the DNA by base excision repair and from the nucleotide pool by the nucleotide sanitization enzyme hMTH1.	8-ohdg	0-8	nudix hydrolase 1	Homo sapiens	124-129
19138035-7	2008	The aim of this work was to establish the dose-response relationship for radiation-induced extracellular 8-oxo-dG and hMTH1 in the mGy range of gamma rays in three cellular model systems: human whole blood, human fibroblasts and stimulated lymphocytes.	8-ohdg	105-113	nudix hydrolase 1	Homo sapiens	118-123
18793663-3	2008	8-Hydroxy-2"-deoxyguanosine (8-OHdG) is one of the most abundant oxidative DNA lesions resulting from ROS, and 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase/lyase enzyme, plays a key role in the removal of 8-OHdG adducts.	8-ohdg	222-228	8-oxoguanine DNA glycosylase	Rattus norvegicus	139-143
18793663-3	2008	8-Hydroxy-2"-deoxyguanosine (8-OHdG) is one of the most abundant oxidative DNA lesions resulting from ROS, and 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase/lyase enzyme, plays a key role in the removal of 8-OHdG adducts.	8-ohdg	0-27	8-oxoguanine DNA glycosylase	Rattus norvegicus	139-143
18793663-3	2008	8-Hydroxy-2"-deoxyguanosine (8-OHdG) is one of the most abundant oxidative DNA lesions resulting from ROS, and 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase/lyase enzyme, plays a key role in the removal of 8-OHdG adducts.	8-ohdg	29-35	8-oxoguanine DNA glycosylase	Rattus norvegicus	111-137
18793663-3	2008	8-Hydroxy-2"-deoxyguanosine (8-OHdG) is one of the most abundant oxidative DNA lesions resulting from ROS, and 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase/lyase enzyme, plays a key role in the removal of 8-OHdG adducts.	8-ohdg	29-35	8-oxoguanine DNA glycosylase	Rattus norvegicus	139-143
18707137-9	2008	SiRNA knockdown of PARP-1 did not affect the 8-OHdG level induced by arsenic, while it greatly increased the 8-OHdG level produced by hydrogen peroxide indicating that PARP-1 is a molecular target of arsenite.	8-ohdg	109-115	poly(ADP-ribose) polymerase 1	Homo sapiens	19-25
18599524-2	2008	RESEARCH DESIGN AND METHODS: Phosphorylation of Akt and tuberin, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) levels, and 8-oxoG-DNA glycosylase (OGG1) expression were measured in kidney cortical tissue of control and type 1 diabetic animals and in proximal tubular cells incubated with normal or high glucose.	8-ohdg	102-109	TSC complex subunit 2	Rattus norvegicus	56-63
18599524-3	2008	RESULTS: In the renal cortex of diabetic rats, the increase in Akt phosphorylation is associated with enhanced phosphorylation of tuberin, decreased OGG1 protein expression, and 8-oxodG accumulation.	8-ohdg	178-185	AKT serine/threonine kinase 1	Rattus norvegicus	63-66
18585103-1	2008	Human 8-oxoguanine-DNA glycosylase 1 (hOGG1) repairs 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) which results from oxidation of guanine.	8-ohdg	53-88	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
18585103-1	2008	Human 8-oxoguanine-DNA glycosylase 1 (hOGG1) repairs 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) which results from oxidation of guanine.	8-ohdg	90-98	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
18854000-8	2008	Furthermore, the cumulative incidence rate of HCC in 39 patients with high 8-OHdG expression levels was significantly greater than that in 65 patients with low 8-OHdG expression levels (P = 0.043).	8-ohdg	75-81	HCC	Homo sapiens	46-49
18854000-8	2008	Furthermore, the cumulative incidence rate of HCC in 39 patients with high 8-OHdG expression levels was significantly greater than that in 65 patients with low 8-OHdG expression levels (P = 0.043).	8-ohdg	160-166	HCC	Homo sapiens	46-49
18854000-10	2008	CONCLUSIONS: 8-OHdG is a risk factor for the development of HCC in patients with chronic HCV infection.	8-ohdg	13-19	HCC	Homo sapiens	60-63
18854000-11	2008	Patients with chronic HCV who express 8-OHdG should be monitored carefully for the development of HCC.	8-ohdg	38-44	HCC	Homo sapiens	98-101
18300266-2	2008	Ogg1 knockout mice are phenotypically normal, but exhibit elevated levels of 8-OHdG in nuclear and mitochondrial DNA, as well as moderately elevated mutagenesis and spontaneous lung tumors and UV-induced skin tumors.	8-ohdg	77-83	8-oxoguanine DNA-glycosylase 1	Mus musculus	0-4
18300266-9	2008	Using immunohistochemical approaches, Ogg1 (-/-) and (+/-) mice exhibited similar numbers and staining intensities of macrophages in UC areas as seen in Ogg1 (+/+) mice, but markedly increased numbers and staining intensities of 8-OHdG positive inflammatory and epithelial cells.	8-ohdg	229-235	8-oxoguanine DNA-glycosylase 1	Mus musculus	38-42
18328070-7	2008	The time-course analysis showed that ferritin and highly sensitive CRP seemed to decrease first, followed by a decrease of 8-OHdG and 8-IsoPs.	8-ohdg	123-129	C-reactive protein	Homo sapiens	67-70
18331251-2	2008	Hepatic 8-OHdG accumulation was investigated in patients with chronic hepatitis C (CH-C) (n = 77) and chronic hepatitis B (CH-B) (n = 34) by immunohistochemical staining of liver biopsy samples.	8-ohdg	8-14	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	83-87
18331251-3	2008	8-OHdG positive hepatocytes were significantly higher in patients with CH-C compared to CH-B (median 55.0 vs 18.8 cells/10(5) mum(2), P < 0.0001).	8-ohdg	0-6	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	71-75
18331251-4	2008	The number of positive hepatocytes significantly increased with the elevation of serum aminotransferase levels, especially in CH-C patients (8-OHdG vs alanine aminotransferase (ALT)/aspartate aminotrasferase (AST) were r = 0.738/0.720 in CH-C and 0.506/0.515 in CH-B).	8-ohdg	141-147	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	126-130
17912498-0	2008	Sulfotransferase 1A1 and glutathione S-transferase P1 genetic polymorphisms modulate the levels of urinary 8-hydroxy-2"-deoxyguanosine in betel quid chewers.	8-ohdg	107-134	sulfotransferase family 1A member 1	Homo sapiens	0-20
17912498-0	2008	Sulfotransferase 1A1 and glutathione S-transferase P1 genetic polymorphisms modulate the levels of urinary 8-hydroxy-2"-deoxyguanosine in betel quid chewers.	8-ohdg	107-134	glutathione S-transferase pi 1	Homo sapiens	25-53
17912498-8	2008	Our results revealed that urinary 8-OHdG level was higher in chewers with SULT1A1 Arg-His genotype than in chewers with SULT1A1 Arg-Arg genotype.	8-ohdg	34-40	sulfotransferase family 1A member 1	Homo sapiens	74-81
17912498-8	2008	Our results revealed that urinary 8-OHdG level was higher in chewers with SULT1A1 Arg-His genotype than in chewers with SULT1A1 Arg-Arg genotype.	8-ohdg	34-40	sulfotransferase family 1A member 1	Homo sapiens	120-127
17912498-9	2008	Urinary 8-OHdG level was also higher in chewers with GSTP1 Ile-Ile genotype.	8-ohdg	8-14	glutathione S-transferase pi 1	Homo sapiens	53-58
18489080-7	2008	An RP-HPLC-ECD assay was used to detect the formation of 8-oxo-dGuo in p53 cDNA exposed to representative quinones, BP-7,8-dione, BA-3,4-dione, and DMBA-3,4-dione under redox cycling conditions.	8-ohdg	57-67	tumor protein p53	Homo sapiens	71-74
18489080-9	2008	Nanomolar concentrations of PAH o-quinones generated 8-oxo-dGuo (detected by HPLC-ECD) in a concentration dependent manner that correlated in a linear fashion with mutagenic frequency.	8-ohdg	53-63	phenylalanine hydroxylase	Homo sapiens	28-31
18489080-10	2008	By contrast, micromolar concentrations of (+/-)- anti-BPDE generated (+)- trans- anti-BPDE-N (2)-dGuo adducts (detected by stable-isotope dilution LC/MS methodology) in p53 cDNA that correlated in a linear fashion with mutagenic frequency, but no 8-oxo-dGuo was detected.	8-ohdg	247-257	tumor protein p53	Homo sapiens	169-172
18275859-4	2008	In these Pten-deleted MEFs, the basal levels of reactive oxygen species (ROS) were increased, and both the basal level and the ROS-induced oxidative damage of DNA were increased, as evidenced by increased levels of hydrogen peroxide (H2O2), superoxide anion, 8-hydroxy-2"-deoxyguanosine, and DNA double-strand breaks.	8-ohdg	259-286	phosphatase and tensin homolog	Mus musculus	9-13
18613397-8	2008	Expression of iNOS also correlated with 8-OHdG (p = 0.02).	8-ohdg	40-46	nitric oxide synthase 2	Homo sapiens	14-18
18598755-6	2008	Overall, our results suggest that decreased OGG1 activity occurs early in the progression of AD, possibly mediated by 4-hydroxynonenal inactivation and may contribute to elevated 8-OHdG in the brain in MCI and LAD.	8-ohdg	179-185	8-oxoguanine DNA glycosylase	Homo sapiens	44-48
18854000-3	2008	The aim of this study was to determine whether expression of 8-OHdG is a risk factor for the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection.	8-ohdg	61-67	HCC	Homo sapiens	134-137
18854000-7	2008	RESULTS: On multivariate analysis, 8-OHdG and fibrosis were independent and significant risk factors for HCC development (relative risk, 2.48; P = 0.023; relative risk, 5.35; P = 0.001, respectively).	8-ohdg	35-41	HCC	Homo sapiens	105-108
18776649-0	2008	OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2"-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa.	8-ohdg	87-114	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
18776649-0	2008	OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2"-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa.	8-ohdg	87-114	mutY DNA glycosylase	Homo sapiens	6-9
18776649-0	2008	OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2"-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa.	8-ohdg	87-114	nudix hydrolase 1	Homo sapiens	14-18
18300266-1	2008	Ogg1 DNA repair enzyme recognizes and excises oxidative stress-caused 8-hydroxyl-deoxyguanosine (8-OHdG) from GC base-pairs.	8-ohdg	97-103	8-oxoguanine DNA-glycosylase 1	Mus musculus	0-4
18423381-8	2008	The mAOPP levels correlated significantly with the oxidative stress markers 8-oxo-dG and pentosidine, whereas no such correlations were found for oAOPP.	8-ohdg	76-84	peroxiredoxin 5	Mus musculus	4-9
18366059-2	2008	8-OHdG is a sensitive marker of DNA oxidation and is repaired by a polymorphic glycosylase (OGG1) more effectively than by OGG1-Cys(326).	8-ohdg	0-6	8-oxoguanine DNA glycosylase	Homo sapiens	92-96
18366059-3	2008	The aims of this study were to ascertain the respective roles of H. pylori, cagA status and OGG1 polymorphism in determining 8-OHdG levels in benign and premalignant stomach diseases and in gastric cancer (GC).	8-ohdg	125-131	8-oxoguanine DNA glycosylase	Homo sapiens	92-96
18366059-10	2008	OGG1 1245C-->G polymorphism was detected in 54% of IMA patients, but only 16% of controls (p = 0.0004) and coincided with significantly higher 8-OHdG levels.	8-ohdg	146-152	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
18366059-11	2008	In the multivariate analysis, 8-OHdG levels were predicted by histotype and OGG1 status.	8-ohdg	30-36	8-oxoguanine DNA glycosylase	Homo sapiens	76-80
18366059-12	2008	OGG1 1245C-->G polymorphism was common in both GC and IMA, but very rare in controls, and correlated more closely with 8-OHdG levels than do H. pylori infection or cagA status.	8-ohdg	122-128	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
18831917-6	2008	Immunohistochemistry also showed that LPS induced a significant increase in 8-hydroxy-2"-deoxyguanosine formation in the lung as compared to vehicle.	8-ohdg	76-103	toll-like receptor 4	Mus musculus	38-41
18335523-6	2008	Immunostaining for 8-hydroxy-2"-deoxyguanosine (8-OHdG) was performed to examine DNA damage in CA1 neurons in both groups after ischemia, and it was found that 8-OHdG immunoreactivity in both FAD and CD groups peaked at 12 hr after reperfusion, although the immunoreactivity in the FAD group was much greater than that in the CD group.	8-ohdg	160-166	carbonic anhydrase 1	Homo sapiens	95-98
18359049-0	2008	Translesion synthesis of 7,8-dihydro-8-oxo-2"-deoxyguanosine by DNA polymerase eta in vivo.	8-ohdg	25-60	DNA polymerase eta	Homo sapiens	64-82
18489080-0	2008	The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance.	8-ohdg	67-77	tumor protein p53	Homo sapiens	15-18
18489080-0	2008	The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance.	8-ohdg	67-77	phenylalanine hydroxylase	Homo sapiens	39-42
18307122-7	2008	Glutathione S-transferase (GST) mRNA expression and protein production in lung tissues were significantly lower in C57BL/6 mice than in BALB/c mice, and 8-hydroxy-2"-deoxyguanosine (8-OHdG) level in the lung tissues were significantly greater in C57BL/6 mice than in BALB/c mice.	8-ohdg	153-180	hematopoietic prostaglandin D synthase	Mus musculus	27-30
18307122-7	2008	Glutathione S-transferase (GST) mRNA expression and protein production in lung tissues were significantly lower in C57BL/6 mice than in BALB/c mice, and 8-hydroxy-2"-deoxyguanosine (8-OHdG) level in the lung tissues were significantly greater in C57BL/6 mice than in BALB/c mice.	8-ohdg	182-188	hematopoietic prostaglandin D synthase	Mus musculus	27-30
18191270-0	2008	Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.	8-ohdg	57-63	lactotransferrin	Rattus norvegicus	7-18
18707137-9	2008	SiRNA knockdown of PARP-1 did not affect the 8-OHdG level induced by arsenic, while it greatly increased the 8-OHdG level produced by hydrogen peroxide indicating that PARP-1 is a molecular target of arsenite.	8-ohdg	109-115	poly(ADP-ribose) polymerase 1	Homo sapiens	168-174
17710513-7	2008	DTIC-induced photodamage to DNA fragments was partially inhibited by catalase, whereas 8-oxodG formation was significantly increased by catalase.	8-ohdg	87-94	catalase	Bos taurus	136-144
18086242-3	2008	The 8-oxoguanine DNA glycosylase (OGG1) enzyme repairs 8-oxo-dG adducts, suggesting that enhancing its activity in the skin might increase 8-oxo-dG repair thus preventing skin cancer development.	8-ohdg	55-63	8-oxoguanine DNA-glycosylase 1	Mus musculus	34-38
18218111-4	2008	Tuberin downregulates the DNA repair enzyme 8-oxoguanine DNA-glycosylase (OGG1) with important functional consequences, compromising the ability of cells to repair damaged DNA resulting in the accumulation of the mutagenic oxidized DNA, 8-oxo-dG.	8-ohdg	237-245	TSC complex subunit 2	Rattus norvegicus	0-7
18086242-3	2008	The 8-oxoguanine DNA glycosylase (OGG1) enzyme repairs 8-oxo-dG adducts, suggesting that enhancing its activity in the skin might increase 8-oxo-dG repair thus preventing skin cancer development.	8-ohdg	139-147	8-oxoguanine DNA-glycosylase 1	Mus musculus	34-38
18155117-1	2008	The carcinogenic mycotoxin aflatoxin B(1) (AFB(1)) induces 8-hydroxy-2"-deoxyguanosine (8-OHdG) formation in mouse lung, an effect that can be prevented by treatment with polyethylene glycol-conjugated catalase (PEG-CAT).	8-ohdg	88-94	catalase	Mus musculus	202-210
18155117-2	2008	G-->T transversion mutation in K-ras, an early event in AFB(1)-induced mouse lung carcinogenesis, is thought to result from AFB(1)-8,9-exo-epoxide binding to DNA to form AFB(1)-N(7)-guanine, but may also result from formation of 8-OHdG.	8-ohdg	232-238	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	34-39
18314486-9	2008	The level of 8-hydroxy-2"-deoxyguanosine was increased by angiotensin II and conversely decreased by candesartan.	8-ohdg	13-40	angiotensinogen	Homo sapiens	58-72
18155253-3	2008	OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress.	8-ohdg	71-78	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
18155253-3	2008	OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress.	8-ohdg	71-78	nei like DNA glycosylase 1	Homo sapiens	6-11
18155253-3	2008	OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress.	8-ohdg	71-78	mutY DNA glycosylase	Homo sapiens	16-21
18155253-11	2008	Furthermore, we found a positive correlation between OGG1 mRNA expression and urinary excretion of 8-oxodG (RS=0.18; p<0.005).	8-ohdg	99-106	8-oxoguanine DNA glycosylase	Homo sapiens	53-57
18164116-7	2008	Furthermore, BNF enhanced oxidative DNA damage and lipid peroxidation, estimated by the levels of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances.	8-ohdg	98-121	natriuretic peptide B	Rattus norvegicus	13-16
18164116-7	2008	Furthermore, BNF enhanced oxidative DNA damage and lipid peroxidation, estimated by the levels of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances.	8-ohdg	123-129	natriuretic peptide B	Rattus norvegicus	13-16
18218111-4	2008	Tuberin downregulates the DNA repair enzyme 8-oxoguanine DNA-glycosylase (OGG1) with important functional consequences, compromising the ability of cells to repair damaged DNA resulting in the accumulation of the mutagenic oxidized DNA, 8-oxo-dG.	8-ohdg	237-245	8-oxoguanine DNA glycosylase	Rattus norvegicus	74-78
18218111-6	2008	We investigated the distribution of protein expression and the activity of OGG1 and 8-oxo-dG and correlated it with the expression of tuberin in kidneys of wild type and Eker rats and tumor from Eker rat.	8-ohdg	84-92	TSC complex subunit 2	Rattus norvegicus	134-141
18218111-8	2008	On the other hand, 8-oxo-dG levels were highest in the medulla, which expressed the lowest levels of OGG1.	8-ohdg	19-27	8-oxoguanine DNA glycosylase	Rattus norvegicus	101-105
17989114-5	2008	Mouse embryonic fibroblasts deficient in tuberin (TSC2(-/-) and TSC2(+/-)) also had markedly decreased OGG1 mRNA and protein expression, as well as undetectable OGG1 activity accompanied by accumulation of 8-oxodG.	8-ohdg	206-213	TSC complex subunit 2	Mus musculus	41-48
17949751-3	2008	Oxidative products to nucleosides, 8-hydroxy-2"-deoxyguanosine and 8-hydroxyguanosine, were accumulated in the lenticulate nucleus predominantly in DRPLA cases having PME.	8-ohdg	35-62	atrophin 1	Homo sapiens	148-153
17932460-1	2008	The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base.	8-ohdg	53-75	8-oxoguanine DNA glycosylase	Homo sapiens	11-37
17932460-1	2008	The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base.	8-ohdg	53-75	8-oxoguanine DNA glycosylase	Homo sapiens	39-43
17932460-1	2008	The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base.	8-ohdg	85-92	8-oxoguanine DNA glycosylase	Homo sapiens	11-37
17932460-1	2008	The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs 8-oxo-2-deoxyguanosine residue (8-oxodG) an oxidatively damaged promutagenic base.	8-ohdg	85-92	8-oxoguanine DNA glycosylase	Homo sapiens	39-43
18184270-1	2008	AIMS: Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA.	8-ohdg	124-147	nitric oxide synthase 2	Homo sapiens	37-58
17764705-4	2008	8-Oxo-7,8-dihydro-2"-deoxyguanosine is repaired by oxoguanine DNA glycosylase 1 (OGG1); upregulation of this repair system was observed as elevated pulmonary OGG1 mRNA levels after 24 h at both doses of DEP, but not in the colon and liver.	8-ohdg	0-35	8-oxoguanine DNA glycosylase	Rattus norvegicus	81-85
18037125-0	2007	Anti-inflammatory effects of 8-hydroxy-2"-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice.	8-ohdg	29-56	thymoma viral proto-oncogene 1	Mus musculus	104-107
18037125-1	2007	Recently, we observed that 8-hydroxyguanosine triphosphate and 8-hydroxy-2"-deoxyguanosine (oh(8)dG) inactivate Rac and consequently down-regulate the Rac-linked NADPH oxidase, iNOS, and Cox2.	8-ohdg	63-90	thymoma viral proto-oncogene 1	Mus musculus	112-115
18037125-1	2007	Recently, we observed that 8-hydroxyguanosine triphosphate and 8-hydroxy-2"-deoxyguanosine (oh(8)dG) inactivate Rac and consequently down-regulate the Rac-linked NADPH oxidase, iNOS, and Cox2.	8-ohdg	63-90	thymoma viral proto-oncogene 1	Mus musculus	151-154
18037125-1	2007	Recently, we observed that 8-hydroxyguanosine triphosphate and 8-hydroxy-2"-deoxyguanosine (oh(8)dG) inactivate Rac and consequently down-regulate the Rac-linked NADPH oxidase, iNOS, and Cox2.	8-ohdg	63-90	cytochrome c oxidase II, mitochondrial	Mus musculus	187-191
17566060-6	2007	Further analysis exhibited a strong inverse correlation between oxidative DNA lesions [8-oxodeoxyguanosine (8-oxo-dG)] and Ref-1 levels in all JB6 cells.	8-ohdg	87-106	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	123-128
17566060-6	2007	Further analysis exhibited a strong inverse correlation between oxidative DNA lesions [8-oxodeoxyguanosine (8-oxo-dG)] and Ref-1 levels in all JB6 cells.	8-ohdg	108-116	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	123-128
17914985-9	2007	The increase in the number of hepatocytes positive for 4-hydroxynonenal and 8-hydroxy-2"-deoxyguanosine in CDAA-fed rats was significantly prevented by the angiotensin II receptor blocker and the Rho kinase inhibitor.	8-ohdg	76-103	angiotensinogen	Rattus norvegicus	156-170
18203092-7	2008	RESULTS: The patients with type 2 diabetes had significantly higher concentrations of 8-OHdG in their urine than the control subjects (19.6+/-6.7 vs 11.9+/-4.9 ng/mgCr; p<0.05).	8-ohdg	86-92	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	163-167
18203092-9	2008	However, HbA1c values were significantly correlated with 8-OHdG values.	8-ohdg	57-63	hemoglobin subunit alpha 1	Homo sapiens	9-13
18569589-1	2008	Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays an important role in the repair of 8-oxo-7, 8-dihydro-2"-deoxyguanosine (8-oxodGuo), one of the major constituents in DNA damage.	8-ohdg	86-122	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
18569589-1	2008	Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays an important role in the repair of 8-oxo-7, 8-dihydro-2"-deoxyguanosine (8-oxodGuo), one of the major constituents in DNA damage.	8-ohdg	124-133	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
18569589-2	2008	A recent in vitro study showed that the hOGG1 326Cys polymorphism (rs1052133) exhibits reduced 8-oxodGuo repair activity.	8-ohdg	95-104	8-oxoguanine DNA glycosylase	Homo sapiens	40-45
18569589-3	2008	This study aimed to develop a LightCycler (LC) assay to analyze the C>G polymorphism (Ser326Cys) in exon 7 of the hOGG1 gene followed by validation of the method using DNA samples from 260 polycyclic aromatic hydrocarbons(PAH)-exposed workers with known 8-oxodGuo DNA-adduct values measured by HPLC.	8-ohdg	257-266	8-oxoguanine DNA glycosylase	Homo sapiens	117-122
18569589-7	2008	The distribution of 8-oxodGuo adducts for the Ser326Cys variants of hOGG1 revealed geometric means (GM) of 5.83 (CC), 5.27 (CG), and 6.53 (GG) 8-oxodGuo adducts/10(6)dGuo.	8-ohdg	20-29	8-oxoguanine DNA glycosylase	Homo sapiens	68-73
18569589-7	2008	The distribution of 8-oxodGuo adducts for the Ser326Cys variants of hOGG1 revealed geometric means (GM) of 5.83 (CC), 5.27 (CG), and 6.53 (GG) 8-oxodGuo adducts/10(6)dGuo.	8-ohdg	143-152	8-oxoguanine DNA glycosylase	Homo sapiens	68-73
18025045-8	2008	Our data indicate that PNP and RR enable nucleotide salvage of 8-oxodG in MCF-7 cells, a previously unrecognized mechanism that may contribute to mutagenesis and carcinogenesis.	8-ohdg	63-70	purine nucleoside phosphorylase	Homo sapiens	23-26
19016153-6	2008	It has been determined that G-Px activity and urinary 8-OHdG level were lower in the patients treated with angiotensin-converting enzyme (ACE) inhibitor compared to patients treated with calcium channel blocker.	8-ohdg	54-60	angiotensin I converting enzyme	Homo sapiens	107-136
19016153-6	2008	It has been determined that G-Px activity and urinary 8-OHdG level were lower in the patients treated with angiotensin-converting enzyme (ACE) inhibitor compared to patients treated with calcium channel blocker.	8-ohdg	54-60	angiotensin I converting enzyme	Homo sapiens	138-141
17961514-4	2007	Gene expression of P47phox, p67phox, and PU.1 were also activated, accompanying increased 8-OHdG in urine and kidney, demonstrating that glomerular SREBP-1c could directly cause oxidative stress through induced NADPH oxidase.	8-ohdg	90-96	sterol regulatory element binding transcription factor 1	Mus musculus	148-156
18053222-9	2007	APE1 148 glu/glu + asp/glu genotype was associated with a decrease in logged 8-OHdG of 0.40 (95%CI -0.73, -0.07) compared to APE1 148 asp/asp.	8-ohdg	77-83	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
18053222-10	2007	An association between total urinary arsenic and 8-OHdG was observed among women with the GSTM1 null genotype but not in women with GSTM1 positive.	8-ohdg	49-55	glutathione S-transferase mu 1	Homo sapiens	90-95
18053222-13	2007	CONCLUSION: These results suggest the APE1 variant genotype decreases repair of 8-OHdG and that arsenic exposure is associated with oxidative stress in women who lack a functional GSTM1 detoxification enzyme.	8-ohdg	80-86	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	38-42
17725985-0	2007	The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2"-deoxyguanosine.	8-ohdg	146-181	twinkle mtDNA helicase	Homo sapiens	63-66
17954367-7	2007	Urinary levels of L-FABP were correlated with those of 8-OHdG (baseline, P = .0001; after 3 months, P = .008) and the severity of proteinuria (baseline, P = .0015; after 3 months, P = .0001).	8-ohdg	55-61	fatty acid binding protein 1	Homo sapiens	18-24
17724371-3	2007	Urinary AFB1 was also associated with both the urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG) (r > or = 0.479, P < 0.001) and 8-OHdG and hOGG1 levels in peripheral leukocytes (r > or = 0.308, P < or = 0.005).	8-ohdg	93-99	8-oxoguanine DNA glycosylase	Homo sapiens	150-155
17724371-5	2007	In addition, urinary 8-OHdG was correlated with both the level of DNA 8-OHdG (r > or = 0.24, P < or = 0.05) and the expression of hOGG1 in peripheral leukocytes (r > or = 0.429, P < 0.001).	8-ohdg	21-27	8-oxoguanine DNA glycosylase	Homo sapiens	136-141
17893046-4	2007	The relationships between SCC and urinary 8-oxodG were analyzed by conditional logistic regression and those between 8-oxodG and other candidate variables by linear regression, correcting for the effect of SCC.	8-ohdg	42-49	serpin family B member 3	Homo sapiens	26-29
17893046-5	2007	In SCC patients, urinary 8-oxodG was significantly elevated (p=0.03), both pre- and post-tumor development, compared to non-SCC transplant patients.	8-ohdg	25-32	serpin family B member 3	Homo sapiens	3-6
17935603-7	2007	Mice over-expressing GDNF also showed less staining for acrolein, nitrotyrosine, and 8-hydroxydeoxyguanosine, indicating less oxidative damage to lipids, proteins, and DNA.	8-ohdg	85-108	glial cell line derived neurotrophic factor	Mus musculus	21-25
17902103-2	2007	In the present work, evidence is provided from (18)[(1)O(2)] and H(2) (18)O labeling experiments, using HPLC-ESI-MS/MS, that the formation of dSp is explained by the addition of water to a reactive quinonoid intermediate, and a second reaction pathway leading to dSp involves (1)O(2) oxidation of initially generated 8-oxodGuo.	8-ohdg	317-326	dsp	Drosophila melanogaster	142-145
17804481-0	2007	AtNUDX1, an 8-oxo-7,8-dihydro-2"-deoxyguanosine 5"-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis.	8-ohdg	12-47	nudix hydrolase 1	Arabidopsis thaliana	0-7
18184270-1	2008	AIMS: Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA.	8-ohdg	124-147	nitric oxide synthase 2	Homo sapiens	60-64
18184270-1	2008	AIMS: Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA.	8-ohdg	149-155	nitric oxide synthase 2	Homo sapiens	37-58
18184270-1	2008	AIMS: Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA.	8-ohdg	149-155	nitric oxide synthase 2	Homo sapiens	60-64
18184270-7	2008	Immunohistochemical iNOS expression was associated with the 8-OHdG labelling index, iNOS mRNA expression and p53 gene alteration (P < 0.0001, P = 0.016 and 0.0082 respectively).	8-ohdg	60-66	nitric oxide synthase 2	Homo sapiens	20-24
17417784-1	2007	The human oxoguanine glycosylase 1(hOGG1) gene encodes a DNA glycosylase that is involved in excision repair of 8-OH-dG (8-hydroxy-2-deoxyguanine) from oxidatively-damaged DNA.	8-ohdg	112-119	8-oxoguanine DNA glycosylase	Homo sapiens	35-40
17951967-5	2007	Although the ethanol treatment significantly increased the hepatic 8-OHdG generation in only Aldh2 +/+ mice, the level of 8-OHdG was the highest in Aldh2 -/- ethanol treated mice.	8-ohdg	122-128	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	148-153
17951967-6	2007	The increase in the level of 8-OHdG was associated with hepatic expression of cytochrome P450 2E1 (CYP2E1).	8-ohdg	29-35	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	78-97
17951967-6	2007	The increase in the level of 8-OHdG was associated with hepatic expression of cytochrome P450 2E1 (CYP2E1).	8-ohdg	29-35	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	99-105
17951967-7	2007	The levels of Olive tail moment and the hepatic 8-OHdG in the Aldh2 -/- control group were significantly higher than those of the Aldh2 +/+ control group.	8-ohdg	48-54	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	62-67
17541572-9	2007	The urinary NAG activity correlated positively with urinary 8-OHdG.	8-ohdg	60-66	O-GlcNAcase	Homo sapiens	12-15
17541572-10	2007	Multiple linear regression showed that urinary NAG activity was an independent predictor of urinary 8-OHdG level.	8-ohdg	100-106	O-GlcNAcase	Homo sapiens	47-50
17603930-3	2007	The present study documented higher 8-hydroxy-2"-deoxyguanosine levels in PC3 cells than in LNCaP cells.	8-ohdg	36-63	chromobox 8	Homo sapiens	74-77
17445838-7	2007	The interesting finding from this study was the significant negative correlation between the level of 8-oxodG adducts and the level of total PAH (bulky) and B[a]P DNA adducts implying that the repair of oxidative DNA damage may be enhanced.	8-ohdg	102-109	phenylalanine hydroxylase	Homo sapiens	141-144
17567683-8	2007	Inhibition of p53 resulted in excessive oxidation of DNA; control SiHa cells exhibited a more rapid removal of 8-oxo-7,8-dihydro-2"-deoxyguanosine from DNA compared with p53-deficient SiHa cells exposed to the same level of H2O2 challenge.	8-ohdg	111-146	tumor protein p53	Homo sapiens	14-17
17393334-6	2007	8-OHdG level was found to be weakly correlated with age, NO, and SOD.	8-ohdg	0-6	superoxide dismutase 1	Homo sapiens	65-68
17206381-3	2007	Upon exposure to 1 mM 3-morpholinosydnomine N-ethylcarbamide (SIN-1), a generator of peroxynitrite through the reaction between nitric oxide and superoxide anion, to U937 cells, the viability was lower and the protein oxidation, lipid peroxidation and oxidative DNA damage reflected by an increase in 8-hydroxy-2"-deoxyguanosine, were higher in the inhibitor-treated cells as compared to the control cells.	8-ohdg	301-328	MAPK associated protein 1	Homo sapiens	62-67
17445838-9	2007	Furthermore the significant inverse correlation between 8-oxodG and B[a]P DNA adducts was confined to individuals carrying the wild type genotype for both the GSTM1 and the GSTT1 gene (separately and interacting).	8-ohdg	56-63	glutathione S-transferase mu 1	Homo sapiens	159-164
17445838-9	2007	Furthermore the significant inverse correlation between 8-oxodG and B[a]P DNA adducts was confined to individuals carrying the wild type genotype for both the GSTM1 and the GSTT1 gene (separately and interacting).	8-ohdg	56-63	glutathione S-transferase theta 1	Homo sapiens	173-178
17620201-8	2007	Cotreatment with an inhibitor of IL-1beta and TNF-alpha synthesis, pentoxifylline, decreased stilbene estrogen-induced levels of myeloperoxidase (MPO), 8-hydroxydeoxyguanosine formation, and gene mutations, and prevented stilbene estrogen-induced lesions.	8-ohdg	152-175	interleukin 1 beta	Homo sapiens	33-41
17441966-7	2007	At week 4, the levels of DNA 8-OH-dG and cell proliferation were significantly elevated in the lungs of non-treated Ogg1(-/-) as compared to Ogg1(+/+) mice and were strongly enhanced by DMA(V) treatment.	8-ohdg	29-36	8-oxoguanine DNA-glycosylase 1	Mus musculus	116-120
17620201-8	2007	Cotreatment with an inhibitor of IL-1beta and TNF-alpha synthesis, pentoxifylline, decreased stilbene estrogen-induced levels of myeloperoxidase (MPO), 8-hydroxydeoxyguanosine formation, and gene mutations, and prevented stilbene estrogen-induced lesions.	8-ohdg	152-175	tumor necrosis factor	Homo sapiens	46-55
17418105-2	2007	In this study, exposing the presenilin 2 transfected PC12 cells to the 50 microM Abeta(25-35), 30 mM l-glutamate and 50 microM H(2)O(2) resulted in significant increase 8-oxodG and p53 levels of the cells expressing the mutant gene.	8-ohdg	169-176	presenilin 2	Rattus norvegicus	28-40
17576376-7	2007	The amount of 8-OHdG increased and viability decreased in response to increased UV dose in both the y v ma-l and wild-type strains.	8-ohdg	14-20	maroon-like	Drosophila melanogaster	104-108
17510393-4	2007	Introduction of oncogenic H- or N-Ras caused elevated intracellular ROS, accumulation of 8-oxo-2"-deoxyguanosine, and increased number of chromosome breaks in mitotic cells, which were prevented by antioxidant N-acetyl-L-cysteine.	8-ohdg	89-112	NRAS proto-oncogene, GTPase	Homo sapiens	32-37
17575397-6	2007	The levels of 8-OHdG increased dose-dependently in mice of both genotypes, but the degree of increase was higher in Pparalpha-null than in wild-type mice.	8-ohdg	14-20	peroxisome proliferator activated receptor alpha	Mus musculus	116-125
17576376-8	2007	With irradiation of 600 kJ m(-2), 8-OHdG/10(6)dG was 7.2 +/- 3.2 and 6.2 +/- 2.0 in y v ma-l and wild-type strains, respectively, whereas the respective levels were 2.2 +/- 0.6 and 2.3 +/- 0.8 without irradiation.	8-ohdg	34-40	maroon-like	Drosophila melanogaster	88-92
17161978-3	2007	MUTYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2"-deoxyguanosine, one of the most stable products of oxidative DNA damage.	8-ohdg	105-140	mutY DNA glycosylase	Homo sapiens	0-5
16956692-9	2007	A negative correlation between preheparin LPL mass and urinary 8-OHdG was observed.	8-ohdg	63-69	lipoprotein lipase	Homo sapiens	42-45
17414424-5	2007	Histaminase counteracted free radical-mediated tissue injury, as judged by a significant decrease in the plasma and tissue levels of peroxidation and nitration products (oxidized rhodamine, malondialdehyde, nitrotyrosine), DNA damage markers (8-hydroxy-2"-deoxyguanosine, poly-adenosine diphosphate-ribosylated DNA) and consumption of tissue antioxidant enzymes (superoxide dismutase).	8-ohdg	243-270	amine oxidase, copper containing 1	Rattus norvegicus	0-11
17195915-5	2007	RESULTS: Significant positive correlations were observed between the number of CD68+ cells, the amount of HNE protein adducts, and the number of 8-OHdG adducts in liver tissue of patients with HCC and HCV.	8-ohdg	145-151	CD68 molecule	Homo sapiens	79-83
17321545-3	2007	Employing single-turnover kinetic methods, we examined human DNA polymerase beta and its novel X-family homolog, human DNA polymerase lambda, to determine which nucleotide and template base was preferred when encountering 8-oxodG and 8-oxodGTP, respectively.	8-ohdg	222-229	DNA polymerase beta	Homo sapiens	61-80
17321545-3	2007	Employing single-turnover kinetic methods, we examined human DNA polymerase beta and its novel X-family homolog, human DNA polymerase lambda, to determine which nucleotide and template base was preferred when encountering 8-oxodG and 8-oxodGTP, respectively.	8-ohdg	222-229	DNA polymerase lambda	Homo sapiens	119-140
17288454-0	2007	Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5"-Cyclopurine-2"-deoxynucleosides and 8-hydroxy-2"-deoxyguanosine.	8-ohdg	120-147	BRCA1 DNA repair associated	Homo sapiens	27-32
17288454-2	2007	Here, we show that lymphoblasts of women with BRCA1 mutations who had been diagnosed with breast cancer are deficient in the repair of some products of oxidative DNA damage, namely, 8-hydroxy-2"-deoxyguanosine and 8,5"-cyclopurine-2"-deoxynucleosides.	8-ohdg	182-209	BRCA1 DNA repair associated	Homo sapiens	46-51
17364961-2	2007	In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland.	8-ohdg	155-178	transferrin	Homo sapiens	101-112
17154177-9	2007	Furthermore, we observed a genotype-phenotype modification between hOGG1 gene polymorphism (Ser326Cys) and levels of 8-OH-dG.	8-ohdg	117-124	8-oxoguanine DNA glycosylase	Homo sapiens	67-72
17214495-9	2007	Biochemical studies revealed that the PP and SPP groups immediately 5", but not 3", to the 8-oxoguanosine (8oxodG) inhibit translesion synthesis by a DNA polymerase in vitro.	8-ohdg	107-113	histocompatibility minor 13	Homo sapiens	45-48
17053817-4	2007	Moreover, UVA-induced hypertrophy and DNA oxidation (8-oxodeoxyguanosine) were decreased by CAT overexpression.	8-ohdg	53-72	catalase	Homo sapiens	92-95
17210448-4	2007	Remarkably, 8-OHdG levels were also significantly related to body and hepatic iron storage markers (vs serum ferritin, r=0.565, p=0.0004; vs hepatic total iron score, r=0.403, p=0.0119; vs hepatic hepcidin messenger RNA, r=0.516, p=0.0013).	8-ohdg	12-18	hepcidin antimicrobial peptide	Homo sapiens	197-205
17364943-3	2007	DEP exposure increased lung levels of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) in Ogg1-/- mice, whereas no effect on 8-oxodG or oxidized purines in terms of formamidopyrimidine DNA glycosylase (FPG) sites was observed in WT mice.	8-ohdg	75-82	8-oxoguanine DNA-glycosylase 1	Mus musculus	87-91
17364943-6	2007	In conclusion, Ogg1-/- mice have elevated pulmonary levels of FPG sites and accumulate genomic 8-oxodG after repeated inhalations of DEP.	8-ohdg	95-102	8-oxoguanine DNA-glycosylase 1	Mus musculus	15-19
16915393-0	2007	8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype.	8-ohdg	0-23	paraoxonase 1	Homo sapiens	117-130
17651912-8	2007	Expression of R229Q OGG1 sensitized KG-1 cells to killing by menadione and 8-hydroxydeoxyguanosine, but not ionizing radiation.	8-ohdg	75-98	8-oxoguanine DNA glycosylase	Homo sapiens	20-24
17319786-7	2007	Alpha fetoprotein was found to be correlated with G-Px in the gastric cancer group and correlated with 8-OHdG in the colon cancer group.	8-ohdg	103-109	alpha fetoprotein	Homo sapiens	0-17
17582205-11	2007	Moreover, associated with the increased renal expression of Txnip, diabetic conditions increased oxidative stress as determined by urinary excretion of 8-hydroxy-2"-deoxyguanosine and acrolein adduct, which are oxidative stress markers.	8-ohdg	152-179	thioredoxin interacting protein	Mus musculus	60-65
16915393-1	2007	OBJECTIVE: In order to investigate a role of paraoxonase 1 (PON1) polymorphism in organophosphorus (OP)-induced 8-hydroxydeoxyguanosine (8-OHdG) levels, urinary metabolites of OP, PON1 genotypes, and 8-OHdG levels in leukocyte and urine were measured in OP indoor insecticide sprayers and controls in summer and winter.	8-ohdg	137-143	paraoxonase 1	Homo sapiens	60-64
17034359-1	2006	Does inflammation, as assessed by high sensitivity C-reactive protein (hs-CRP), in patients with end-stage renal disease (ESRD) tightly associate with increased serum levels of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8- oxo-dG)?	8-ohdg	177-212	C-reactive protein	Homo sapiens	51-69
17652324-1	2007	The harmfulness of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8oxodG) damage resides on its dual coding potential, as it can pair with the correct dCMP (dC) or the incorrect dAMP (dA).	8-ohdg	19-54	Amphiphysin	Drosophila melanogaster	168-172
17652324-1	2007	The harmfulness of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8oxodG) damage resides on its dual coding potential, as it can pair with the correct dCMP (dC) or the incorrect dAMP (dA).	8-ohdg	56-62	Amphiphysin	Drosophila melanogaster	168-172
17145855-3	2006	Here, we show that TNF-alpha exposure results in increased production of reactive oxygen species (ROS), with a concomitant increase in the production of 8-oxo-deoxyguanosine, a marker for oxidative DNA damage, in human lung bronchial epithelial cells.	8-ohdg	153-173	tumor necrosis factor	Homo sapiens	19-28
18029664-3	2007	For example, 8-oxodG in the syn conformation is complementary to adenine in the hydrogen bonding.	8-ohdg	13-20	synemin	Homo sapiens	28-31
17034359-1	2006	Does inflammation, as assessed by high sensitivity C-reactive protein (hs-CRP), in patients with end-stage renal disease (ESRD) tightly associate with increased serum levels of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8- oxo-dG)?	8-ohdg	214-223	C-reactive protein	Homo sapiens	51-69
17050167-5	2006	The overexpression of MnSOD enhanced the accumulation of 8-oxodGuo by UV.	8-ohdg	57-66	superoxide dismutase 2	Homo sapiens	22-27
16861056-0	2006	Activity of OGG1 variants in the repair of pro-oxidant-induced 8-oxo-2"-deoxyguanosine.	8-ohdg	63-86	8-oxoguanine DNA glycosylase	Homo sapiens	12-16
16861056-3	2006	The 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated base excision repair (BER) pathway operates to remove 8-oxodG lesions.	8-ohdg	106-113	8-oxoguanine DNA glycosylase	Homo sapiens	36-40
17050167-6	2006	The co-overexpression of catalase inhibited the accumulation of 8-oxodGuo by UV in MnSOD-transfectants.	8-ohdg	64-73	catalase	Homo sapiens	25-33
17050167-6	2006	The co-overexpression of catalase inhibited the accumulation of 8-oxodGuo by UV in MnSOD-transfectants.	8-ohdg	64-73	superoxide dismutase 2	Homo sapiens	83-88
17015165-6	2006	In the same retina, MnSOD overexpression also inhibited diabetes-induced increases in the levels of 8-OHdG and nitrotyrosine.	8-ohdg	100-106	superoxide dismutase 2, mitochondrial	Mus musculus	20-25
16511502-8	2006	Hepatocyte growth factor prevented the primary oxidative DNA damage, as was estimated by using anti-8-OHdG (8-hydroxy-2"-deoxyguanosine) antibody.	8-ohdg	100-106	hepatocyte growth factor	Homo sapiens	0-24
16511502-8	2006	Hepatocyte growth factor prevented the primary oxidative DNA damage, as was estimated by using anti-8-OHdG (8-hydroxy-2"-deoxyguanosine) antibody.	8-ohdg	108-135	hepatocyte growth factor	Homo sapiens	0-24
17023266-0	2006	8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia.	8-ohdg	0-23	prostaglandin-endoperoxide synthase 2	Mus musculus	53-58
17023266-0	2006	8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia.	8-ohdg	0-23	Rac family small GTPase 1	Mus musculus	72-76
16678259-1	2006	We previously found that 8-oxo-7,8-dihydro-2"-deoxyguanosine (oh(8)dG) kills KG-1, a human myelocytic leukemic cell line with mutational loss of 8-oxoguanine glycosylase (OGG1) activity in vitro.	8-ohdg	25-60	8-oxoguanine DNA glycosylase	Homo sapiens	171-175
16858012-8	2006	Serum HO-1 levels also correlated inversely with serum 8-hydroxydeoxyguanosine levels and positively with vital capacity and forced expiratory volume in one second in patients with silicosis.	8-ohdg	55-78	heme oxygenase 1	Homo sapiens	6-10
16895796-3	2006	Drosophila DNA glycosylases, dOgg1 and RpS3, were ectopically expressed within the mitochondrial matrix in Drosophila S2 cells, causing a severalfold decrease in the levels of 8-oxodG in mitochondrial DNA.	8-ohdg	176-183	8-oxoguanine DNA glycosylase	Drosophila melanogaster	29-34
16569655-4	2006	hOGG1 is a key enzyme in short patch BER because it recognizes and performs initial excision of the most common form of oxidative DNA base damage, 8-hydroxyguanine (8-oxo-dG).	8-ohdg	165-173	8-oxoguanine DNA glycosylase	Homo sapiens	0-5
17093398-0	2006	Oxidative stress in pterygium: relationship between p53 and 8-hydroxydeoxyguanosine.	8-ohdg	60-83	tumor protein p53	Homo sapiens	52-55
17093398-7	2006	To verify a possible significant association between p53 and 8-OHdG, we examined a series of 31 Ecuadorian pterygia for the expression of the two markers.	8-ohdg	61-67	tumor protein p53	Homo sapiens	53-56
17093398-16	2006	All samples positive for p53 (11/31, 35.48%) were also positive for 8-OHdG immunostaining, and all specimens negative for 8-OHdG (10/31, 32.26%) were also negative for p53.	8-ohdg	68-74	tumor protein p53	Homo sapiens	25-28
17093398-17	2006	When analyzed by Fisher"s exact test, 8-OHdG expression was significantly associated with p53 positivity (p=0.0049).	8-ohdg	38-44	tumor protein p53	Homo sapiens	90-93
17093398-20	2006	CONCLUSIONS: Although pterygium is a lesion with limited local invasion and an inability to metastasize, the concomitant presence of altered p53 in 8-OHdG-immunoreactive cells could provide evidence of apparent genetic instability, which is in contrast to its benign clinical course.	8-ohdg	148-154	tumor protein p53	Homo sapiens	141-144
16624439-7	2006	Addition of the aldose reductase inhibitor SNK-860 dose-dependently decreased the intracellular sorbitol concentration in HUVECs incubated in high glucose medium, and also significantly suppressed the increases in fragmented DNA, caspase-3 activity and 8-OHdG by conditioning with high glucose medium.	8-ohdg	253-259	aldo-keto reductase family 1 member B	Homo sapiens	16-32
16624439-7	2006	Addition of the aldose reductase inhibitor SNK-860 dose-dependently decreased the intracellular sorbitol concentration in HUVECs incubated in high glucose medium, and also significantly suppressed the increases in fragmented DNA, caspase-3 activity and 8-OHdG by conditioning with high glucose medium.	8-ohdg	253-259	polo like kinase 2	Homo sapiens	43-46
16895796-3	2006	Drosophila DNA glycosylases, dOgg1 and RpS3, were ectopically expressed within the mitochondrial matrix in Drosophila S2 cells, causing a severalfold decrease in the levels of 8-oxodG in mitochondrial DNA.	8-ohdg	176-183	Ribosomal protein S3	Drosophila melanogaster	39-43
16797759-5	2006	In vivo, a small subset of hypertrophic reactive astrocytes, often showing a multinucleated morphology, expressed 14-3-3sigma in active demyelinating lesions of multiple sclerosis (MS) and ischemic lesions of cerebral infarction, where the expression of 4-HNE and 8-hydroxy-2"-deoxyguanosine was enhanced in reactive astrocytes.	8-ohdg	264-291	stratifin	Homo sapiens	114-125
16953121-0	2006	Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression.	8-ohdg	29-52	signal transducer and activator of transcription 3	Mus musculus	105-110
16953121-0	2006	Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression.	8-ohdg	29-52	intercellular adhesion molecule 1	Mus musculus	120-153
16707486-5	2006	Simultaneous treatments with PEDF inhibited the AGE-elicited VEGF-mediated permeability by down-regulating mRNA levels of p22(phox) and gp91(phox), membrane components of NADPH oxidase, and subsequently decreasing retinal levels of an oxidative stress marker, 8-hydroxydeoxyguanosine.	8-ohdg	260-283	serpin family F member 1	Rattus norvegicus	29-33
16863995-4	2006	The aim of this work was to investigate the nucleotide pool and the role of the human mutT homologue protein (hMTH1) in the appearance of extracellular 8-oxo-dG in a cellular model system.	8-ohdg	152-160	nudix hydrolase 1	Homo sapiens	110-115
16863995-7	2006	Our results demonstrate the profound effect of both hMTH1 expression and nucleotide pool size on the cellular excretion of 8-oxo-dG, suggesting that the nucleotide pool is a significant target for the formation of extracellular 8-oxo-dG.	8-ohdg	123-131	nudix hydrolase 1	Homo sapiens	52-57
16863995-7	2006	Our results demonstrate the profound effect of both hMTH1 expression and nucleotide pool size on the cellular excretion of 8-oxo-dG, suggesting that the nucleotide pool is a significant target for the formation of extracellular 8-oxo-dG.	8-ohdg	228-236	nudix hydrolase 1	Homo sapiens	52-57
16707486-5	2006	Simultaneous treatments with PEDF inhibited the AGE-elicited VEGF-mediated permeability by down-regulating mRNA levels of p22(phox) and gp91(phox), membrane components of NADPH oxidase, and subsequently decreasing retinal levels of an oxidative stress marker, 8-hydroxydeoxyguanosine.	8-ohdg	260-283	vascular endothelial growth factor A	Rattus norvegicus	61-65
16707486-5	2006	Simultaneous treatments with PEDF inhibited the AGE-elicited VEGF-mediated permeability by down-regulating mRNA levels of p22(phox) and gp91(phox), membrane components of NADPH oxidase, and subsequently decreasing retinal levels of an oxidative stress marker, 8-hydroxydeoxyguanosine.	8-ohdg	260-283	cytochrome b-245 alpha chain	Rattus norvegicus	141-145
16810758-13	2006	There was a significant difference in urinary excretion of 8-OHdG between the CCl4-treated and MA-treated groups.	8-ohdg	59-65	C-C motif chemokine ligand 4	Rattus norvegicus	78-82
16804062-7	2006	The diabetic AR(-/-) mice also excreted less 8-hydroxy-2"-deoxyguanosine in urine than diabetic AR(+/+) mice.	8-ohdg	45-72	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	13-15
16401636-13	2006	The correlations between % change of 8-OHdG and plasma leptin was also significant (partial correlation coefficient r = 0.51, n = 27, P = 0.02).	8-ohdg	37-43	leptin	Homo sapiens	55-61
16517504-2	2006	Our hypothesis is that there should be a positive correlation between the levels of 8-hydroxy-2"-deoxyguanosine (8OHdG) and 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) in major rat tissues.	8-ohdg	84-111	placental growth factor	Rattus norvegicus	161-164
16804401-10	2006	RESULTS: A significant improvement was observed in DAI score and histologic severity as well as in mucosal tissue levels of inflammatory cytokines, 8-OHdG, and MDA of mice treated with the EC-SOD gene as compared with those without gene therapy, not only in a mild colitis model but also in a severe colitis model.	8-ohdg	148-154	superoxide dismutase 3, extracellular	Mus musculus	189-195
16547075-6	2006	The addition of catalase to culture medium reduced 8OHdG levels and the intensity of dichlorofluorescin fluorescence, while 4NQO generated hydroxyl radicals in the cell-free system.	8-ohdg	51-56	catalase	Homo sapiens	16-24
16678011-5	2006	Moreover, the 8-hydoxy-2"-deoxyguanosine (8-OHdG) expression seen in Wt mice after mAb/LPS injection was almost completely inhibited in TRX-Tg mice.	8-ohdg	42-48	thioredoxin 1	Mus musculus	136-139
16472828-3	2006	Our previous study showed that the addition of 8-oxo-dG to culture media caused an accumulation of 8-oxo-Gua in nuclear DNA in several leukemic cells including KG-1, which lack 8-oxoguanine glycosylase 1 (OGG1) activity due to mutational loss.	8-ohdg	47-55	8-oxoguanine DNA glycosylase	Homo sapiens	177-203
16472828-3	2006	Our previous study showed that the addition of 8-oxo-dG to culture media caused an accumulation of 8-oxo-Gua in nuclear DNA in several leukemic cells including KG-1, which lack 8-oxoguanine glycosylase 1 (OGG1) activity due to mutational loss.	8-ohdg	47-55	8-oxoguanine DNA glycosylase	Homo sapiens	205-209
16472828-8	2006	Interestingly, the activity of DNA polymerase beta, which synthesize DNA with low fidelity increased in KG-1 cells treated with 8-oxo-dG, whereas the expression of DNA polymerase alpha decreased.	8-ohdg	128-136	DNA polymerase beta	Homo sapiens	31-50
16472828-10	2006	Thus, our findings address that the insertion of 8-oxo-dG into KG-1 DNA is not due to the direct incorporation of exogenous 8-oxo-dG, but rather to the inaccurate incorporation of endogenous 8-oxo-dGTP by DNA polymerase beta.	8-ohdg	49-57	DNA polymerase beta	Homo sapiens	205-224
16797605-6	2006	Administration of PEDF or pyridoxal phosphate, an AGE inhibitor, decreased retinal levels of 8-OHdG and subsequently suppressed ICAM-1 gene expression and retinal leukostasis in diabetic rats.	8-ohdg	93-99	serpin family F member 1	Rattus norvegicus	18-22
16364924-4	2006	Oxoguanine glycosylase (OGG1) is the base excision enzyme repairing 8-oxodG in DNA by release of 8-oxoguanine.	8-ohdg	68-75	8-oxoguanine DNA glycosylase	Homo sapiens	24-28
16696575-5	2006	The predominant source of AP sites, however, was revealed by coupling the assay with human 8-oxoguanine glycosylase (hOGG1) treatment, showing that 8-oxo-dGuo was the major lesion caused by PAH o-quinones.	8-ohdg	148-158	8-oxoguanine DNA glycosylase	Homo sapiens	117-122
16517504-2	2006	Our hypothesis is that there should be a positive correlation between the levels of 8-hydroxy-2"-deoxyguanosine (8OHdG) and 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) in major rat tissues.	8-ohdg	113-118	placental growth factor	Rattus norvegicus	161-164
16614128-2	2006	OGG1 encodes an 8-oxoguanine DNA glycosylase/AP lyase that catalyzes the removal of 8-oxodeoxyguanosine from DNA.	8-ohdg	84-103	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
16517504-4	2006	Our results show positive correlations between 8OHdG and 8-iso-PGF(2alpha) for liver, brain and kidney measured by HPLC-UV-ECD (electrochemical detector) and EIA methods, respectively.	8-ohdg	47-52	placental growth factor	Rattus norvegicus	63-66
16614128-2	2006	OGG1 encodes an 8-oxoguanine DNA glycosylase/AP lyase that catalyzes the removal of 8-oxodeoxyguanosine from DNA.	8-ohdg	84-103	8-oxoguanine DNA glycosylase	Homo sapiens	16-44
16596994-3	2006	The formation of 8-hydroxy-2"-deoxyguanosine (8-OH-dG) in calf thymus DNA by SIN-1 was also inhibited by dietary antioxidants.	8-ohdg	17-44	MAPK associated protein 1	Homo sapiens	77-82
16614128-2	2006	OGG1 encodes an 8-oxoguanine DNA glycosylase/AP lyase that catalyzes the removal of 8-oxodeoxyguanosine from DNA.	8-ohdg	84-103	8-oxoguanine DNA glycosylase	Homo sapiens	45-53
17699218-4	2006	Patients with MPO activity greater than the median had significantly (P < 0.05) lower serum albumin levels (33.2 +/- 0.7 versus 35.0 +/- 0.5 g/L), higher 8-hydroxydeoxyguanosine levels (1.26 +/- 0.08 versus 1.05 +/- 0.06 ng/ml), and a lower prevalence of statin treatment (18 versus 36%).	8-ohdg	157-180	myeloperoxidase	Homo sapiens	14-17
16596994-3	2006	The formation of 8-hydroxy-2"-deoxyguanosine (8-OH-dG) in calf thymus DNA by SIN-1 was also inhibited by dietary antioxidants.	8-ohdg	46-53	MAPK associated protein 1	Homo sapiens	77-82
16449021-11	2006	TAS and Gal-1-P inversely correlated to 8-OHdG (r= -0.802, p < 0.001), whereas Gal-1-P positively correlated to 8-OHdG (r = 0.820, p < 0.001) in all the groups.	8-ohdg	115-121	galectin 1	Homo sapiens	82-87
16615267-6	2006	The genotypes of the GPX1 and 8-oxoguanine glycosylase 1 (hOGG1) genes were examined and the concentrations of urinary 1-hydroxypyrene (1-OHP), 2-naphthol and 8-hydroxydeoxyguanosine (8-OH-dG) were measured.	8-ohdg	159-182	8-oxoguanine DNA glycosylase	Homo sapiens	58-63
16615267-6	2006	The genotypes of the GPX1 and 8-oxoguanine glycosylase 1 (hOGG1) genes were examined and the concentrations of urinary 1-hydroxypyrene (1-OHP), 2-naphthol and 8-hydroxydeoxyguanosine (8-OH-dG) were measured.	8-ohdg	184-191	8-oxoguanine DNA glycosylase	Homo sapiens	58-63
16293446-4	2006	We show that the mitochondrial form of Ogg1 is functionally active at processing 8-oxo-dGuo lesions and that Ogg1-deficient cells exhibit nearly six-fold elevated rate of Arg+ mutants under normal growth condition, as compared to the parent.	8-ohdg	81-91	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	39-43
16293446-7	2006	These findings provide in vivo evidence that oxidative stress induces the formation of lesions, most likely 8-oxo-dGuo, which must be repaired by Ogg1, otherwise the lesions can trigger poly(GT) tract instability in the mitochondrial genome.	8-ohdg	108-118	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	146-150
16449021-12	2006	CONCLUSION: a) Low TAS and high Gal-1-P levels are implicated with high 8-OHdG blood levels in galactosaemic patients; b) 8-OHdG may be a sensitive biomarker of DNA damage in patients with classical galactosaemia.	8-ohdg	72-78	galectin 1	Homo sapiens	32-37
16298757-9	2006	4-Hydrazinobenzoic acid increased formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG), a characteristic oxidative DNA lesion, in calf thymus DNA, whereas 4-hydrazinobenzoic acid did not increase the formation of 8-oxodG in the presence of catalase.	8-ohdg	84-91	catalase	Bos taurus	246-254
16085125-4	2006	In a variety of cell lines, we show that ectopic MYC over-expression results in the elevation of intracellular ROS levels and a concomitant increase in oxidative DNA damage, as assessed by levels of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) in the genomic DNA.	8-ohdg	199-234	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-52
16085125-4	2006	In a variety of cell lines, we show that ectopic MYC over-expression results in the elevation of intracellular ROS levels and a concomitant increase in oxidative DNA damage, as assessed by levels of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) in the genomic DNA.	8-ohdg	236-244	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-52
16052517-0	2006	Oh8dG induces G1 arrest in a human acute leukemia cell line by upregulating P21 and blocking the RAS to ERK signaling pathway.	8-ohdg	0-5	H3 histone pseudogene 16	Homo sapiens	76-79
16052517-1	2006	We reported previously that KG-1, a human acute leukemia cell line, has mutational loss of 8-oxoguanine (8-hydroxyguanine; oh8Gua) glycosylase 1 (OGG1) activity and undergoes apoptotic death after treatment with 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodeoxyguanosine, 8-hydroxydeoxyguanosine; oh8dG).	8-ohdg	212-247	8-oxoguanine DNA glycosylase	Homo sapiens	146-150
16052517-1	2006	We reported previously that KG-1, a human acute leukemia cell line, has mutational loss of 8-oxoguanine (8-hydroxyguanine; oh8Gua) glycosylase 1 (OGG1) activity and undergoes apoptotic death after treatment with 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodeoxyguanosine, 8-hydroxydeoxyguanosine; oh8dG).	8-ohdg	249-268	8-oxoguanine DNA glycosylase	Homo sapiens	146-150
16052517-1	2006	We reported previously that KG-1, a human acute leukemia cell line, has mutational loss of 8-oxoguanine (8-hydroxyguanine; oh8Gua) glycosylase 1 (OGG1) activity and undergoes apoptotic death after treatment with 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodeoxyguanosine, 8-hydroxydeoxyguanosine; oh8dG).	8-ohdg	270-293	8-oxoguanine DNA glycosylase	Homo sapiens	146-150
16052517-1	2006	We reported previously that KG-1, a human acute leukemia cell line, has mutational loss of 8-oxoguanine (8-hydroxyguanine; oh8Gua) glycosylase 1 (OGG1) activity and undergoes apoptotic death after treatment with 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodeoxyguanosine, 8-hydroxydeoxyguanosine; oh8dG).	8-ohdg	295-300	8-oxoguanine DNA glycosylase	Homo sapiens	146-150
16052517-3	2006	Simultaneously, oh8dG-treated KG-1 showed an increase in the oh8Gua content of DNA, upregulation of p21 (an inhibitor of cdk), and Ras inactivation.	8-ohdg	16-21	H3 histone pseudogene 16	Homo sapiens	100-103
16052517-9	2006	We report that oh8dG induces the arrest of KG-1 growth at the G1 phase mainly by upregulating p21 and inactivating Ras.	8-ohdg	15-20	H3 histone pseudogene 16	Homo sapiens	94-97
16106417-1	2006	The human OGG1 gene encodes a DNA glycosylase that is involved in the base excision repair of 8-hydroxy-2"-deoxyguanine (8-OH-dG) from oxidatively damaged DNA.	8-ohdg	121-128	8-oxoguanine DNA glycosylase	Homo sapiens	10-14
16187124-6	2006	RESULTS: The lymphocytic 8-OH-dG level showed a negative association with the serum dioxin level (total value of TEQ-PCDD, PCDF, and Co-PCB).	8-ohdg	25-32	pyruvate carboxylase	Homo sapiens	136-139
16084535-4	2006	However, significant differences of regression coefficient were found for the relation between urinary log 1-OHP and urinary 8-OHdG concentrations in the presence of different MnSOD or MPO genotypes by multiple regression after controlling for age, sex, body mass index, cotinine, and smoking.	8-ohdg	125-131	superoxide dismutase 2	Homo sapiens	176-181
16084535-4	2006	However, significant differences of regression coefficient were found for the relation between urinary log 1-OHP and urinary 8-OHdG concentrations in the presence of different MnSOD or MPO genotypes by multiple regression after controlling for age, sex, body mass index, cotinine, and smoking.	8-ohdg	125-131	myeloperoxidase	Homo sapiens	185-188
16094703-6	2005	HIF-1alpha expression was correlated with inducible nitric oxide synthase (iNOS) expression (r = 0.369 and P = 0.025) and 8-oxodG formation (r = 0.398 and P = 0.015).	8-ohdg	122-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
16333523-3	2006	Human 8-oxoguanine glycosylase (hOGG1) is the key component responsible for the removal of 8-OHdG from oxidatively damaged DNA.	8-ohdg	91-97	8-oxoguanine DNA glycosylase	Homo sapiens	32-37
16122734-5	2005	Both replicating and senescing NHOK expressed readily detectable 8-oxo-dG DNA glycosylase (hOGG1), the enzyme responsible for glycosidic cleavage of 8-oxo-dG.	8-ohdg	65-73	8-oxoguanine DNA glycosylase	Homo sapiens	91-96
16122734-5	2005	Both replicating and senescing NHOK expressed readily detectable 8-oxo-dG DNA glycosylase (hOGG1), the enzyme responsible for glycosidic cleavage of 8-oxo-dG.	8-ohdg	149-157	8-oxoguanine DNA glycosylase	Homo sapiens	91-96
16610557-4	2006	At 125 ppm acetaldehyde exposure for 12 d, urinary 8-OHdG levels in Aldh2+/+ mice did not increase.	8-ohdg	51-57	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	68-73
16610557-5	2006	However, urinary 8-OHdG levels in Aldh2-/- mice were slightly increased by the end of the exposure.	8-ohdg	17-23	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	34-39
16610557-7	2006	At 500 ppm, urinary 8-OHdG levels in both Aldh2-/- and Aldh2+/+ mice significantly increased after 6 and 12 d, but there was no genetic difference.	8-ohdg	20-26	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	42-47
16610557-7	2006	At 500 ppm, urinary 8-OHdG levels in both Aldh2-/- and Aldh2+/+ mice significantly increased after 6 and 12 d, but there was no genetic difference.	8-ohdg	20-26	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	55-60
17065072-3	2006	Comparable levels of 8-hydroxydeoxyguanosine (8-OHdG) were present in urine from controls and DPD patients at the age <2 year.	8-ohdg	21-44	dihydropyrimidine dehydrogenase	Homo sapiens	94-97
17065072-3	2006	Comparable levels of 8-hydroxydeoxyguanosine (8-OHdG) were present in urine from controls and DPD patients at the age <2 year.	8-ohdg	46-52	dihydropyrimidine dehydrogenase	Homo sapiens	94-97
17065072-4	2006	In contrast, slightly elevated levels of 8-OHdG were detected in urine from DPD patients with an age >2 year, suggesting the presence of increased oxidative stress.	8-ohdg	41-47	dihydropyrimidine dehydrogenase	Homo sapiens	76-79
16273539-7	2005	Induction of 8-OH-dG was present in both the GCL and INL of the glaucomatous retina at 3 days after the onset of glaucoma before significant neuronal death was observed.	8-ohdg	13-20	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	45-48
16245950-5	2005	Moreover, XRCC1 mutant EM9 cells possess steady-state levels of endogenous 8-OH-dG base damage similar to those of their wild-type counterparts.	8-ohdg	75-82	DNA repair protein XRCC1	Cricetulus griseus	10-15
15885732-4	2005	In contrast, induction of GST-P positive foci and liver tumors tended to be inhibited at a dose of 0.005 ppm, correlating with protein levels of cytochrome P450 2B1 and 3A2 (CYP2B1 and 3A2) and generation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage.	8-ohdg	208-235	glutathione S-transferase pi 1	Rattus norvegicus	26-31
15885732-4	2005	In contrast, induction of GST-P positive foci and liver tumors tended to be inhibited at a dose of 0.005 ppm, correlating with protein levels of cytochrome P450 2B1 and 3A2 (CYP2B1 and 3A2) and generation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage.	8-ohdg	237-243	glutathione S-transferase pi 1	Rattus norvegicus	26-31
15979101-8	2005	8-oxodGuo levels were significantly higher in older mouse liver DNA than younger, and increased significantly with CCl4 treatment.	8-ohdg	0-9	chemokine (C-C motif) ligand 4	Mus musculus	115-119
16157017-6	2005	The total urinary 8-OHdG contents showed significant correlation (r=0.87, p<0.01) with serum S100beta values, which are reportedly related to brain damage.	8-ohdg	18-24	S100 calcium binding protein B	Homo sapiens	96-104
15922295-2	2005	Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets of animal models of Type 2 diabetes, OLETF rats (60 weeks of age) and db/db mice (14 weeks of age), compared with age-matched controls, respectively, correlating with increased levels of oxidative stress marker, 8-hydroxy-deoxyguanosine or 4-hydroxy-2-nonenal modified protein.	8-ohdg	356-380	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	60-67
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	275-310	tyrosine aminotransferase	Homo sapiens	41-44
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	275-310	tyrosine aminotransferase	Homo sapiens	107-110
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	275-310	8-oxoguanine DNA glycosylase	Homo sapiens	146-150
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	275-310	8-oxoguanine DNA glycosylase	Homo sapiens	152-182
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	312-320	tyrosine aminotransferase	Homo sapiens	41-44
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	312-320	tyrosine aminotransferase	Homo sapiens	107-110
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	312-320	8-oxoguanine DNA glycosylase	Homo sapiens	146-150
15929986-1	2005	To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	312-320	8-oxoguanine DNA glycosylase	Homo sapiens	152-182
15929986-5	2005	Interestingly, although Tat induces oxidative stress known to generate 8-oxo-dG, which causes the G:C to T:A transversion, we observed that the amount of 8-oxo-dG was reduced by Tat.	8-ohdg	71-79	tyrosine aminotransferase	Homo sapiens	24-27
15929986-5	2005	Interestingly, although Tat induces oxidative stress known to generate 8-oxo-dG, which causes the G:C to T:A transversion, we observed that the amount of 8-oxo-dG was reduced by Tat.	8-ohdg	71-79	tyrosine aminotransferase	Homo sapiens	178-181
15929986-5	2005	Interestingly, although Tat induces oxidative stress known to generate 8-oxo-dG, which causes the G:C to T:A transversion, we observed that the amount of 8-oxo-dG was reduced by Tat.	8-ohdg	154-162	tyrosine aminotransferase	Homo sapiens	24-27
15929986-5	2005	Interestingly, although Tat induces oxidative stress known to generate 8-oxo-dG, which causes the G:C to T:A transversion, we observed that the amount of 8-oxo-dG was reduced by Tat.	8-ohdg	154-162	tyrosine aminotransferase	Homo sapiens	178-181
15929986-6	2005	When OGG1 was knocked down by small interfering RNA, Tat increased the amount of 8-oxo-dG, thus confirming the role of OGG1 in preventing the formation of 8-oxo-dG.	8-ohdg	81-89	8-oxoguanine DNA glycosylase	Homo sapiens	5-9
15929986-6	2005	When OGG1 was knocked down by small interfering RNA, Tat increased the amount of 8-oxo-dG, thus confirming the role of OGG1 in preventing the formation of 8-oxo-dG.	8-ohdg	81-89	tyrosine aminotransferase	Homo sapiens	53-56
15929986-6	2005	When OGG1 was knocked down by small interfering RNA, Tat increased the amount of 8-oxo-dG, thus confirming the role of OGG1 in preventing the formation of 8-oxo-dG.	8-ohdg	155-163	8-oxoguanine DNA glycosylase	Homo sapiens	5-9
15929986-6	2005	When OGG1 was knocked down by small interfering RNA, Tat increased the amount of 8-oxo-dG, thus confirming the role of OGG1 in preventing the formation of 8-oxo-dG.	8-ohdg	155-163	tyrosine aminotransferase	Homo sapiens	53-56
15929986-6	2005	When OGG1 was knocked down by small interfering RNA, Tat increased the amount of 8-oxo-dG, thus confirming the role of OGG1 in preventing the formation of 8-oxo-dG.	8-ohdg	155-163	8-oxoguanine DNA glycosylase	Homo sapiens	119-123
16323636-12	2005	There was a significant correlation between the urinary levels of 8-OH-dG and 1-OHP in those with the PON1 Q/Q genotype.	8-ohdg	66-73	paraoxonase 1	Homo sapiens	102-106
16024777-0	2005	The 3"->5" exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae.	8-ohdg	76-107	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	29-33
15922295-2	2005	Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets of animal models of Type 2 diabetes, OLETF rats (60 weeks of age) and db/db mice (14 weeks of age), compared with age-matched controls, respectively, correlating with increased levels of oxidative stress marker, 8-hydroxy-deoxyguanosine or 4-hydroxy-2-nonenal modified protein.	8-ohdg	356-380	cytochrome b-245 beta chain	Rattus norvegicus	88-96
15834708-4	2005	Human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a key component of the base excision repair (BER) pathway and catalyzes the removal of 8-OHdG.	8-ohdg	135-141	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
16000635-10	2005	DNA damage, assessed as 8-hydroxy-2-deoxyguanosine and single-stranded DNA, accumulated within injured MNs and was attenuated by nNOS and iNOS deficiency.	8-ohdg	24-50	nitric oxide synthase 1, neuronal	Mus musculus	129-133
15962292-3	2005	Cells staining positively for 8-OHdG were localized to the cytoplasm of hepatocytes adjacent to the TNF-alpha expressing inflammatory cells in the portal areas or in patches surrounded by inflammatory cells in the hepatic sinusoids.	8-ohdg	30-36	tumor necrosis factor	Rattus norvegicus	100-109
15970406-4	2005	Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-D-glucosaminidase activity on day 1, and with those of 8-hydroxy-2"-deoxyguanosine on days 25-30.	8-ohdg	153-180	fatty acid binding protein 1	Homo sapiens	8-14
15962292-8	2005	Studies of hepatocytes cultured from normal rats displayed dose-dependent relationships between TNF-alpha concentration and 8-OHdG and mtDNA mutation.	8-ohdg	124-130	tumor necrosis factor	Rattus norvegicus	96-105
15757539-7	2005	Rank correlation analysis showed that protein expression of 8-OH-dG positively correlated with those of k-ras (RS=0.643, P < 0.01), and p53 (RS=0.827, P < 0.01)u protein expression of k-ras positively correlated with that of p53 (RS=0.897, P < 0.01).	8-ohdg	60-67	KRAS proto-oncogene, GTPase	Homo sapiens	104-109
15716488-7	2005	Formation of 8-hydroxy-2"-deoxyguanosine (8-OHdG) was significantly elevated in group 4 (p < 0.01), along with expression of alpha-smooth muscle actin (alpha-SMA) and stellate cell activation-associated protein (STAP), as determined by RT-PCR analysis (p < 0.01).	8-ohdg	42-48	cytoglobin	Rattus norvegicus	170-213
15716488-7	2005	Formation of 8-hydroxy-2"-deoxyguanosine (8-OHdG) was significantly elevated in group 4 (p < 0.01), along with expression of alpha-smooth muscle actin (alpha-SMA) and stellate cell activation-associated protein (STAP), as determined by RT-PCR analysis (p < 0.01).	8-ohdg	42-48	cytoglobin	Rattus norvegicus	215-219
15721984-2	2005	Mice null for oxoguanine DNA glycosylase (OGG1) are deficient in 8-oxodG removal and accumulate 8-oxodG in mtDNA to levels 20-fold higher than in wild-type mice (N.C. Souza-Pinto et al., 2001, Cancer Res.	8-ohdg	65-72	8-oxoguanine DNA-glycosylase 1	Mus musculus	42-46
15721984-2	2005	Mice null for oxoguanine DNA glycosylase (OGG1) are deficient in 8-oxodG removal and accumulate 8-oxodG in mtDNA to levels 20-fold higher than in wild-type mice (N.C. Souza-Pinto et al., 2001, Cancer Res.	8-ohdg	96-103	8-oxoguanine DNA-glycosylase 1	Mus musculus	42-46
15962938-0	2005	Formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling.	8-ohdg	13-48	phenylalanine hydroxylase	Homo sapiens	65-68
15962938-0	2005	Formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling.	8-ohdg	50-60	phenylalanine hydroxylase	Homo sapiens	65-68
15962938-9	2005	HPLC-ECD analysis revealed that in the presence of NADPH and Cu(II), submicromolar concentrations of PAH o-quinones generated >60.0 8-oxo-dGuo adducts/10(5) dGuo.	8-ohdg	135-145	phenylalanine hydroxylase	Homo sapiens	101-104
15962938-11	2005	The formation of 8-oxo-dGuo by PAH o-quinones was concentration-dependent.	8-ohdg	17-27	phenylalanine hydroxylase	Homo sapiens	31-34
15962938-16	2005	These data showed that the production of 8-oxo-dGuo was dependent on Cu(II)/Cu(I) catalyzed redox cycling of PAH o-quinones to produce ROS and that the immediate oxidant was not hydroxyl radical or Cu(I)OOH and that it is more likely (1)O(2), which can produce a 4,8-endoperoxide-dGuo intermediate.	8-ohdg	41-51	phenylalanine hydroxylase	Homo sapiens	109-112
16181103-4	2005	In Wt mice, Ang II/salt loading increased urinary excretion of 8- hydroxydeoxyguanosine (8-OHdG) and 8-lso-Prostaglandin F2 alpha.	8-ohdg	63-87	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	12-18
16181103-4	2005	In Wt mice, Ang II/salt loading increased urinary excretion of 8- hydroxydeoxyguanosine (8-OHdG) and 8-lso-Prostaglandin F2 alpha.	8-ohdg	89-95	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	12-18
15757539-2	2005	8-hydoxy-2deoxy-guanosine (8-OH-dG), a biomarker of oxidative DNA damage, plays important roles in initiation, progression, and prognosis of lung cancer, and closely relates with mutations of k-ras and p53 genes in carcinogenesis of lung tissue.	8-ohdg	27-34	KRAS proto-oncogene, GTPase	Homo sapiens	192-197
15757539-2	2005	8-hydoxy-2deoxy-guanosine (8-OH-dG), a biomarker of oxidative DNA damage, plays important roles in initiation, progression, and prognosis of lung cancer, and closely relates with mutations of k-ras and p53 genes in carcinogenesis of lung tissue.	8-ohdg	27-34	tumor protein p53	Homo sapiens	202-205
15757539-7	2005	Rank correlation analysis showed that protein expression of 8-OH-dG positively correlated with those of k-ras (RS=0.643, P < 0.01), and p53 (RS=0.827, P < 0.01)u protein expression of k-ras positively correlated with that of p53 (RS=0.897, P < 0.01).	8-ohdg	60-67	tumor protein p53	Homo sapiens	139-142
15757539-7	2005	Rank correlation analysis showed that protein expression of 8-OH-dG positively correlated with those of k-ras (RS=0.643, P < 0.01), and p53 (RS=0.827, P < 0.01)u protein expression of k-ras positively correlated with that of p53 (RS=0.897, P < 0.01).	8-ohdg	60-67	KRAS proto-oncogene, GTPase	Homo sapiens	190-195
15757539-7	2005	Rank correlation analysis showed that protein expression of 8-OH-dG positively correlated with those of k-ras (RS=0.643, P < 0.01), and p53 (RS=0.827, P < 0.01)u protein expression of k-ras positively correlated with that of p53 (RS=0.897, P < 0.01).	8-ohdg	60-67	tumor protein p53	Homo sapiens	231-234
15692461-7	2005	Moreover, human 8-oxoguanine glycosylase (hOGG1) is the key component responsible for the removal of 8-OHdG.	8-ohdg	101-107	8-oxoguanine DNA glycosylase	Homo sapiens	42-47
15692461-12	2005	In pterygium with 8-OHdG staining, there were 4 (4/11, 36.4%) specimens with hOGG1 expression.	8-ohdg	18-24	8-oxoguanine DNA glycosylase	Homo sapiens	77-82
15692461-14	2005	hOGG1 expression was significantly associated with 8-OHdG positive staining.	8-ohdg	51-57	8-oxoguanine DNA glycosylase	Homo sapiens	0-5
15692461-17	2005	The increased level of 8-OHdG in pterygium is not due to decreased expression of hOGG1, while increased levels of 8-OHdG induced the expression of hOGG1.	8-ohdg	114-120	8-oxoguanine DNA glycosylase	Homo sapiens	147-152
15629370-5	2005	Soluble CD40L significantly correlated with 8-OHdG (r=0.85, p <0.0001) and prothrombin F1+2 (r=0.83, p <0.0001); a significant correlation between 8-OHdG and prothrombin F1+2 was also observed (r=0.64, p <0.0001).	8-ohdg	44-50	CD40 ligand	Homo sapiens	8-13
15629370-5	2005	Soluble CD40L significantly correlated with 8-OHdG (r=0.85, p <0.0001) and prothrombin F1+2 (r=0.83, p <0.0001); a significant correlation between 8-OHdG and prothrombin F1+2 was also observed (r=0.64, p <0.0001).	8-ohdg	153-159	CD40 ligand	Homo sapiens	8-13
16366378-1	2005	UNLABELLED: The human OGG1 (hOGG1) gene encodes a DNA glycosylase involved in the excision repair of 8-hydroxy-2"-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA.	8-ohdg	128-135	8-oxoguanine DNA glycosylase	Homo sapiens	22-26
15626539-4	2005	Cases of XPA but not CS demonstrated nuclear deposition of 8-hydroxy-2"-deoxyguanosine and cytoplasmic deposition of 8-hydroxyguanosine, being speculated as oxidative stress-related materials of DNA and RNA, respectively, in the globus pallidus.	8-ohdg	59-86	XPA, DNA damage recognition and repair factor	Homo sapiens	9-12
15576237-11	2004	Formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine was significantly increased by CYP2D6-treated eugenol in the presence of Cu(II).	8-ohdg	13-48	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	80-86
16366378-1	2005	UNLABELLED: The human OGG1 (hOGG1) gene encodes a DNA glycosylase involved in the excision repair of 8-hydroxy-2"-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA.	8-ohdg	128-135	8-oxoguanine DNA glycosylase	Homo sapiens	28-33
15491640-2	2004	Brain cells in Hq mice contain the modified base 8-hydroxydeoxyguanosine (8-OHdG), suggesting that the defect in Aif causes increased DNA oxidation in these cells.	8-ohdg	49-72	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	113-116
15596047-2	2004	8-Hydroxydeoxyguanine (8-OHdG) formation is one of the most common types of oxidative DNA damage, while human oxoguanine glycosylase 1 (hOGG1) is responsible for repairing 8-OHdG lesions.	8-ohdg	23-29	8-oxoguanine DNA glycosylase	Homo sapiens	136-141
15596047-2	2004	8-Hydroxydeoxyguanine (8-OHdG) formation is one of the most common types of oxidative DNA damage, while human oxoguanine glycosylase 1 (hOGG1) is responsible for repairing 8-OHdG lesions.	8-ohdg	172-178	8-oxoguanine DNA glycosylase	Homo sapiens	136-141
15574998-8	2004	Protein and mRNA expressions of p47phox and iNOS were upregulated in KK/Ta kidneys, which also showed increased immunostaining intensities of 8-OHdG and nitrotyrosine.	8-ohdg	142-148	neutrophil cytosolic factor 1	Mus musculus	32-39
15574998-8	2004	Protein and mRNA expressions of p47phox and iNOS were upregulated in KK/Ta kidneys, which also showed increased immunostaining intensities of 8-OHdG and nitrotyrosine.	8-ohdg	142-148	nitric oxide synthase 2, inducible	Mus musculus	44-48
15477005-0	2004	Cellular 8-oxo-7,8-dihydro-2"-deoxyguanosine 5"-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate.	8-ohdg	9-44	nudix (nucleoside diphosphate linked moiety X)-type motif 1	Mus musculus	110-114
15491640-2	2004	Brain cells in Hq mice contain the modified base 8-hydroxydeoxyguanosine (8-OHdG), suggesting that the defect in Aif causes increased DNA oxidation in these cells.	8-ohdg	74-80	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	113-116
15505070-6	2004	IL-1beta also increased the levels of 8-hydroxy-2"-deoxyguanosine (an indicator of oxidative stress) and nitric oxide by more than 40% and activated NF-kappaB by 35% to 55%.	8-ohdg	38-65	interleukin 1 beta	Rattus norvegicus	0-8
15531653-3	2004	The subsequent mechanism ensuring a dC:8-oxo-dG pair, a substrate for 8-oxoguanine DNA glycosylase (OGG1), remains to be elucidated.	8-ohdg	39-47	8-oxoguanine DNA glycosylase	Homo sapiens	70-98
15531653-3	2004	The subsequent mechanism ensuring a dC:8-oxo-dG pair, a substrate for 8-oxoguanine DNA glycosylase (OGG1), remains to be elucidated.	8-ohdg	39-47	8-oxoguanine DNA glycosylase	Homo sapiens	100-104
15736438-2	2004	MATERIALS AND METHODS: We examined the expression of CDKN1A and Gadd45 proteins acting on cell cycle checkpoints and DNA repair in PCa relative to the presence of oxidative DNA damage, as measured by the detection of the DNA adduct 8-hydroxy-2-deoxyguanosine (8-OHdG.).	8-ohdg	232-258	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-59
15736438-2	2004	MATERIALS AND METHODS: We examined the expression of CDKN1A and Gadd45 proteins acting on cell cycle checkpoints and DNA repair in PCa relative to the presence of oxidative DNA damage, as measured by the detection of the DNA adduct 8-hydroxy-2-deoxyguanosine (8-OHdG.).	8-ohdg	232-258	growth arrest and DNA damage inducible alpha	Homo sapiens	64-70
15736438-2	2004	MATERIALS AND METHODS: We examined the expression of CDKN1A and Gadd45 proteins acting on cell cycle checkpoints and DNA repair in PCa relative to the presence of oxidative DNA damage, as measured by the detection of the DNA adduct 8-hydroxy-2-deoxyguanosine (8-OHdG.).	8-ohdg	260-266	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-59
15736438-2	2004	MATERIALS AND METHODS: We examined the expression of CDKN1A and Gadd45 proteins acting on cell cycle checkpoints and DNA repair in PCa relative to the presence of oxidative DNA damage, as measured by the detection of the DNA adduct 8-hydroxy-2-deoxyguanosine (8-OHdG.).	8-ohdg	260-266	growth arrest and DNA damage inducible alpha	Homo sapiens	64-70
15337697-8	2004	Immunohistochemical analysis showed that TRX-1 significantly suppressed cardiac macrophage inflammatory protein (MIP)-1alpha, MIP-2, and 8-hydroxydeoxyguanosine expression and macrophage infiltration into the heart in EAM.	8-ohdg	137-160	thioredoxin 1	Mus musculus	41-46
15520857-5	2004	Emphysema in Nrf2-deficient mice exposed to CS for 6 months was associated with more pronounced bronchoalveolar inflammation; with enhanced alveolar expression of 8-oxo-7,8-dihydro-2"-deoxyguanosine, a marker of oxidative stress; and with an increased number of apoptotic alveolar septal cells--predominantly endothelial and type II epithelial cells--as compared with wild-type mice.	8-ohdg	163-198	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
15304255-7	2004	Catalase inhibited 4-HC-induced DNA damage, including 8-oxodG formation, suggesting the involvement of H(2)O(2).	8-ohdg	54-61	catalase	Homo sapiens	0-8
15288533-8	2004	Parameters of inflammation (percentage of macrophages and TNF-alpha secretion) correlated significantly with the induction of 8-OHdG, 10 weeks after treatment.	8-ohdg	126-132	tumor necrosis factor	Rattus norvegicus	58-67
15178435-3	2004	A significant accumulation of proliferating cell nuclear antigen, a prognostic factor for gastric cancer, was observed in gastric gland epithelial cells in patients with H. pylori infection as compared to those without infection, and its accumulation was closely correlated with the formation of 8-nitroguanine and 8-oxodG.	8-ohdg	315-322	proliferating cell nuclear antigen	Homo sapiens	30-64
15388266-3	2004	We found that 8-hydroxy-2"-deoxyguanosine (8OHdG), which is a product of oxidative DNA damage, increases with age in livers and pancreata of C57BL/6aly/aly (aly/aly) and C57BL/6 wild type (WT) mice.	8-ohdg	14-41	mitogen-activated protein kinase kinase kinase 14	Mus musculus	148-151
15388266-3	2004	We found that 8-hydroxy-2"-deoxyguanosine (8OHdG), which is a product of oxidative DNA damage, increases with age in livers and pancreata of C57BL/6aly/aly (aly/aly) and C57BL/6 wild type (WT) mice.	8-ohdg	14-41	mitogen-activated protein kinase kinase kinase 14	Mus musculus	152-155
15388266-3	2004	We found that 8-hydroxy-2"-deoxyguanosine (8OHdG), which is a product of oxidative DNA damage, increases with age in livers and pancreata of C57BL/6aly/aly (aly/aly) and C57BL/6 wild type (WT) mice.	8-ohdg	14-41	mitogen-activated protein kinase kinase kinase 14	Mus musculus	152-155
15388266-3	2004	We found that 8-hydroxy-2"-deoxyguanosine (8OHdG), which is a product of oxidative DNA damage, increases with age in livers and pancreata of C57BL/6aly/aly (aly/aly) and C57BL/6 wild type (WT) mice.	8-ohdg	43-48	mitogen-activated protein kinase kinase kinase 14	Mus musculus	148-151
15388266-3	2004	We found that 8-hydroxy-2"-deoxyguanosine (8OHdG), which is a product of oxidative DNA damage, increases with age in livers and pancreata of C57BL/6aly/aly (aly/aly) and C57BL/6 wild type (WT) mice.	8-ohdg	43-48	mitogen-activated protein kinase kinase kinase 14	Mus musculus	152-155
15388266-3	2004	We found that 8-hydroxy-2"-deoxyguanosine (8OHdG), which is a product of oxidative DNA damage, increases with age in livers and pancreata of C57BL/6aly/aly (aly/aly) and C57BL/6 wild type (WT) mice.	8-ohdg	43-48	mitogen-activated protein kinase kinase kinase 14	Mus musculus	152-155
15388266-4	2004	The 8OHdG levels in liver, but not in pancreas, of aged aly/aly mice were significantly higher than those in age-matched WT mice.	8-ohdg	4-9	mitogen-activated protein kinase kinase kinase 14	Mus musculus	56-59
15388266-4	2004	The 8OHdG levels in liver, but not in pancreas, of aged aly/aly mice were significantly higher than those in age-matched WT mice.	8-ohdg	4-9	mitogen-activated protein kinase kinase kinase 14	Mus musculus	60-63
15342409-4	2004	Using synthetic DNA containing 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxoG), we showed that p53 was pulled down together with two BER proteins, human 8-oxoguanine glycosylase (hOGG1) and AP endonuclease (APE).	8-ohdg	31-66	tumor protein p53	Homo sapiens	92-95
15342409-4	2004	Using synthetic DNA containing 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxoG), we showed that p53 was pulled down together with two BER proteins, human 8-oxoguanine glycosylase (hOGG1) and AP endonuclease (APE).	8-ohdg	31-66	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	187-202
15342409-4	2004	Using synthetic DNA containing 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxoG), we showed that p53 was pulled down together with two BER proteins, human 8-oxoguanine glycosylase (hOGG1) and AP endonuclease (APE).	8-ohdg	68-74	tumor protein p53	Homo sapiens	92-95
15552932-4	2004	The mean concentration of urinary 8-OHdG in healthy control and patients with liver cirrhosis, chronic hepatitis C, chronic hepatitis B, and autoimmune hepatitis were 10.40+/-3.14, 10.14+/-4.19, 11.79+/-5.58, 14.99+/-4.46, and 13.64+/-3.84 microg/gCr, respectively.	8-ohdg	34-40	nuclear receptor subfamily 3 group C member 1	Homo sapiens	247-250
15552932-6	2004	The mean concentration of urinary 8-OHdG in inveterate drinker was significantly higher than that in non-drinker (16.67+/-4.29 vs. 11.19+/-4.80 microg/gCr, p<0.05).	8-ohdg	34-40	nuclear receptor subfamily 3 group C member 1	Homo sapiens	151-154
15273962-3	2004	In this study, we investigated whether polymorphisms of glutathione S-transferase (GSTM1 and GSTT1) can modulate the relationship between urinary 8-OH-dG and 1-OHP concentrations among the COWs.	8-ohdg	146-153	glutathione S-transferase Mu 1	Bos taurus	83-88
15273962-3	2004	In this study, we investigated whether polymorphisms of glutathione S-transferase (GSTM1 and GSTT1) can modulate the relationship between urinary 8-OH-dG and 1-OHP concentrations among the COWs.	8-ohdg	146-153	glutathione S-transferase theta-1	Bos taurus	93-98
15273962-6	2004	RESULTS: Urinary 1-OHP and 8-OH-dG concentrations (mean +/- SD) in the topside-oven workers with the presence of GSTM1 were 107.2 +/- 107.9 and 15.3 +/- 9.7 ng/ml, respectively, which were not significantly different from those in the absence of GSTM1 (84.1 +/- 104.5 and 12.8 +/- 14.1 ng/ml).	8-ohdg	27-34	glutathione S-transferase Mu 1	Bos taurus	113-118
15253739-7	2004	The decrease in 8-OHdG levels after vitamin C supplementation was also noted in the patients with ferritin <500 or > or =500 microg/L and transferrin saturation (TSAT) <50 or > or =50% (P < 0.05).	8-ohdg	16-22	transferrin	Homo sapiens	144-155
15031674-0	2004	Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells.	8-ohdg	39-58	8-oxoguanine DNA glycosylase	Homo sapiens	80-84
14716324-2	2004	The highly mutagenic 8-hydroxy-2"-deoxyguanosine, a marker for the evaluation of photo-oxidative DNA damage, can be repaired by human 8-oxoguanine glycosylase I (hOGG1).	8-ohdg	21-48	8-oxoguanine DNA glycosylase	Homo sapiens	162-167
15017214-6	2004	Only age was significantly associated with 8-OHdG/Cr in prostate cancer cases among several clinicopathological factors, including serum PSA clinical T stage, metastasis and Gleason score.	8-ohdg	43-49	kallikrein related peptidase 3	Homo sapiens	137-140
14980699-4	2004	We demonstrate here that a subset of mice with partial deficiency of the mitochondrial superoxide dismutase (Sod2(-/+)) show increased incidence of spontaneous and handling-induced seizures that correlates with chronic mitochondrial oxidative stress (increased aconitase inactivation and 8-hydroxy-2"-deoxyguanosine formation in mitochondria) and diminished mitochondrial oxygen utilization.	8-ohdg	288-315	superoxide dismutase 2, mitochondrial	Mus musculus	109-113
14980702-7	2004	Decreases in both the intracellular G6PD activity and the NADPH/NADP(+) ratio were concomitant with an increase in 8-OHdG level in H(2)O(2)-induced senescent cells.	8-ohdg	115-121	glucose-6-phosphate dehydrogenase	Homo sapiens	36-40
15081772-11	2004	There was a linear relationship between ROS production and 8-OHdG formation in cells co-exposed to BaP and UV-A.	8-ohdg	59-65	prohibitin 2	Homo sapiens	99-102
15081772-12	2004	Results of this study suggest that UV-A and BaP act synergistically to enhance ROS production and formation of 8-OHdG, resulting in increased DNA damage.	8-ohdg	111-117	prohibitin 2	Homo sapiens	44-47
15031674-5	2004	APAP significantly reduced the 8- oxodG incision activity in the nucleus by decreasing the activity and content of a DNA repair enzyme, Ogg1.	8-ohdg	31-39	8-oxoguanine DNA glycosylase	Homo sapiens	136-140
15031674-6	2004	These results indicate that APAP in large doses can increase the 8-oxodG level partly through significant reduction of Ogg1 DNA repair enzyme.	8-ohdg	65-72	8-oxoguanine DNA glycosylase	Homo sapiens	119-123
14578299-5	2003	The adding of the PKC inhibitors bisindolylmaleimide-I and LY379196, a specific inhibitor of PKC-beta isoforms, normalized nitrotyrosine and reduced 8-OHdG concentration and cell apoptosis in both stable and intermittent high glucose.	8-ohdg	149-155	protein kinase C beta	Homo sapiens	18-21
20021139-10	2004	Coaddition of superoxide dismutase and catalase along with nicotine reversed the 8-OH-dG generation.	8-ohdg	81-88	catalase isozyme 1	Nicotiana tabacum	39-47
14612962-6	2003	Using a modified Comet assay, to measure DNA damage we have demonstrated that TNF-alpha causes the formation of 8-oxo-deoxyguanosine (8-oxodG), an established marker of oxidative DNA damage, and a lesion associated with chronic hepatitis in human livers.	8-ohdg	112-132	tumor necrosis factor	Mus musculus	78-87
14612962-6	2003	Using a modified Comet assay, to measure DNA damage we have demonstrated that TNF-alpha causes the formation of 8-oxo-deoxyguanosine (8-oxodG), an established marker of oxidative DNA damage, and a lesion associated with chronic hepatitis in human livers.	8-ohdg	134-141	tumor necrosis factor	Mus musculus	78-87
14634453-1	2003	PURPOSE: The human oxoguanine glycosylase 1 (hOGG1) gene encodes a DNA glycosylase that is involved in excision repair of 8-OH-dG (8-hydroxy-2-deoxyguanine) from oxidatively damaged DNA.	8-ohdg	122-129	8-oxoguanine DNA glycosylase	Homo sapiens	45-50
14634453-8	2003	CONCLUSIONS: These results suggest that hOGG1 may have a role in the repair of 8-OH-dG adducts in prostate tissue and hOGG1 Ser326Cys polymorphism is associated with prostate cancer risk.	8-ohdg	79-86	8-oxoguanine DNA glycosylase	Homo sapiens	40-45
12919963-6	2003	However, the mRNA expression of OGG1, encoding an enzyme involved in repair of 8-oxodG, was increased by DEP in both liver and colon.	8-ohdg	79-86	8-oxoguanine DNA glycosylase	Rattus norvegicus	32-36
14679299-3	2003	The Sod2+/- mice have increased oxidative damage as demonstrated by significantly elevated levels of 8-oxo-2-deoxyguanosine (8oxodG) in nuclear DNA in all tissues of Sod2+/- mice studied.	8-ohdg	101-123	superoxide dismutase 2, mitochondrial	Mus musculus	4-8
14679299-3	2003	The Sod2+/- mice have increased oxidative damage as demonstrated by significantly elevated levels of 8-oxo-2-deoxyguanosine (8oxodG) in nuclear DNA in all tissues of Sod2+/- mice studied.	8-ohdg	125-131	superoxide dismutase 2, mitochondrial	Mus musculus	4-8
14679299-3	2003	The Sod2+/- mice have increased oxidative damage as demonstrated by significantly elevated levels of 8-oxo-2-deoxyguanosine (8oxodG) in nuclear DNA in all tissues of Sod2+/- mice studied.	8-ohdg	125-131	superoxide dismutase 2, mitochondrial	Mus musculus	166-170
14679299-4	2003	The levels of 8oxodG in nuclear DNA increased with age in all tissues of Sod2+/- and wild-type (WT) mice, and at 26 mo of age, the levels of 8oxodG in nuclear DNA were significantly higher (from 15% in heart to over 60% in liver) in the Sod2+/- mice compared with WT mice.	8-ohdg	14-20	superoxide dismutase 2, mitochondrial	Mus musculus	73-77
14679299-5	2003	The level of 8oxodG was also higher in mitochondrial DNA isolated from liver and brain in Sod2+/- mice compared with WT mice.	8-ohdg	13-19	superoxide dismutase 2, mitochondrial	Mus musculus	90-94
14646212-2	2003	They showed significant formation of 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA), whereas the oysters that had a low mortality rate from the disease had high activity of superoxide dismutase (SOD) and low amounts of 8-OHdG and MDA.	8-ohdg	231-237	superoxide dismutase 1	Homo sapiens	185-205
14578299-5	2003	The adding of the PKC inhibitors bisindolylmaleimide-I and LY379196, a specific inhibitor of PKC-beta isoforms, normalized nitrotyrosine and reduced 8-OHdG concentration and cell apoptosis in both stable and intermittent high glucose.	8-ohdg	149-155	protein kinase C beta	Homo sapiens	93-101
14578299-6	2003	Similar results were obtained with the MnSOD mimetic Mn(III)tetrakis(4-benzoic acid)porphyrin chloride that normalized nitrotyrosine, 8-OHdG, and apoptosis and inhibited PKC activation.	8-ohdg	134-140	superoxide dismutase 2	Homo sapiens	39-44
14514646-4	2003	Urinary 8-hydroxydeoxyguanosine excretion and its intense immune-reactive staining in the glomeruli were markedly higher in diabetic than in control rats, and these alterations were ameliorated by a treatment with a selective PKC-beta inhibitor, ruboxistaurin (RBX; LY333531) mesylate, without affecting glycemia.	8-ohdg	8-31	protein kinase C, beta	Rattus norvegicus	226-234
14572612-6	2003	In addition, oxidative damage was increased in the MEFs from the Gpx4(+/-) mice, as indicated by increased levels of F(2)-isoprostanes and 8-oxo-2-deoxyguanosine in these cells.	8-ohdg	139-161	glutathione peroxidase 4	Mus musculus	65-69
14653227-5	2003	Lipid peroxide (malondialdehyde) and DNA peroxide (8-hydroxy-2"-deoxyguanosine) levels in the hippocampus of klotho mutant mice increased at the age of 5 weeks, 2 weeks prior to the development of cognition deficits.	8-ohdg	51-78	klotho	Mus musculus	109-115
15012720-5	2003	As a result, the serum 8-OHdG level was strongly correlated with serum levels of urea nitrogen (UN; r = 0.58; P < 0.0001), creatinine (Cr; r = 0.53; P < 0.0001), and beta2-microglobulin (beta2-MG; r = 0.54; P < 0.0001).	8-ohdg	23-29	beta-2-microglobulin	Homo sapiens	172-191
12911319-1	2003	Altered p50 binding affinity and repair shielding by 7,8-dihydro-8-oxo-2"-deoxyguanosine lesions in the NF-kappaB promoter element.	8-ohdg	53-88	nuclear factor kappa B subunit 1	Homo sapiens	8-11
12911319-5	2003	We have used the p50 subunit of the NF-kappaB transcription factor to show that oxidation of guanine to 8-oxo-dG at sites critical for protein recognition impacts transcription factor binding affinity differently depending upon the site of oxidation.	8-ohdg	104-112	nuclear factor kappa B subunit 1	Homo sapiens	17-20
12911319-9	2003	We have observed that substitution of 8-oxo-dG at the G(1) site increases p50 binding affinity by approximately 2.5-fold compared to that of the unmodified DNA sequence, while substitution at G(3) reduces the binding affinity by approximately 4-fold.	8-ohdg	38-46	nuclear factor kappa B subunit 1	Homo sapiens	74-77
12911319-11	2003	Both Escherichia coli fapy glycosylase (Fpg) and human 8-oxo-DNA glycosylase (hOGG1) recognized and cleaved 8-oxo-dG at all four sites within the promoter element.	8-ohdg	108-116	8-oxoguanine DNA glycosylase	Homo sapiens	78-83
12807726-9	2003	Suppression of 8-OHdG formation by PB at low dose might be related to the enhanced mRNA expression of 8-OHdG repair enzyme, oxoguanine glycosylase 1 (Ogg1).	8-ohdg	15-21	8-oxoguanine DNA glycosylase	Rattus norvegicus	124-148
12807726-9	2003	Suppression of 8-OHdG formation by PB at low dose might be related to the enhanced mRNA expression of 8-OHdG repair enzyme, oxoguanine glycosylase 1 (Ogg1).	8-ohdg	15-21	8-oxoguanine DNA glycosylase	Rattus norvegicus	150-154
12807726-9	2003	Suppression of 8-OHdG formation by PB at low dose might be related to the enhanced mRNA expression of 8-OHdG repair enzyme, oxoguanine glycosylase 1 (Ogg1).	8-ohdg	102-108	8-oxoguanine DNA glycosylase	Rattus norvegicus	124-148
12807726-9	2003	Suppression of 8-OHdG formation by PB at low dose might be related to the enhanced mRNA expression of 8-OHdG repair enzyme, oxoguanine glycosylase 1 (Ogg1).	8-ohdg	102-108	8-oxoguanine DNA glycosylase	Rattus norvegicus	150-154
12899941-1	2003	The putative modulation of the base excision repair enzyme, human 8-oxoguanine glycosylase (hOGG1), important in the removal of the potentially mutagenic lesion 8-oxo-2"-deoxyguanosine (8-oxodG), was investigated in human cell culture models.	8-ohdg	161-184	8-oxoguanine DNA glycosylase	Homo sapiens	92-97
12899941-1	2003	The putative modulation of the base excision repair enzyme, human 8-oxoguanine glycosylase (hOGG1), important in the removal of the potentially mutagenic lesion 8-oxo-2"-deoxyguanosine (8-oxodG), was investigated in human cell culture models.	8-ohdg	186-193	8-oxoguanine DNA glycosylase	Homo sapiens	92-97
14632162-11	2003	Increased 8-OHdG levels correlated with diminished SOD activity and decreased GSH content in patients with ED.	8-ohdg	10-16	superoxide dismutase 1	Homo sapiens	51-54
15012720-5	2003	As a result, the serum 8-OHdG level was strongly correlated with serum levels of urea nitrogen (UN; r = 0.58; P < 0.0001), creatinine (Cr; r = 0.53; P < 0.0001), and beta2-microglobulin (beta2-MG; r = 0.54; P < 0.0001).	8-ohdg	23-29	beta-2-microglobulin	Homo sapiens	193-201
12752735-3	2003	AIMS: To ascertain whether cagA-positive H. pylori infection correlates with higher concentrations of 8OHdG and the presence of precancerous changes.	8-ohdg	102-107	S100 calcium binding protein A8	Homo sapiens	27-31
12798451-9	2003	Conversely, 8-OH-dG levels were significantly higher in GSTM1-null than in GSTM1-positive subjects.	8-ohdg	12-19	glutathione S-transferase mu 1	Homo sapiens	56-61
12798451-9	2003	Conversely, 8-OH-dG levels were significantly higher in GSTM1-null than in GSTM1-positive subjects.	8-ohdg	12-19	glutathione S-transferase mu 1	Homo sapiens	75-80
12880480-14	2003	SIN-1 induced the expression of alpha-synuclein, caspase-3, and 8-hydroxy-2-deoxyguanosine, and augmented protein nitration.	8-ohdg	64-90	MAPK associated protein 1	Homo sapiens	0-5
12752735-13	2003	cagA-positive patients had higher 8-hydroxydeoxyguanosine levels than both cagA-negative and H. pylori-negative cases (p = 0.01).	8-ohdg	34-57	S100 calcium binding protein A8	Homo sapiens	0-4
12752735-15	2003	The odds ratio for cagA-positive patients having 8OHdG levels above a cut-off calculated on the basis of the ROC curves were 7.12, overall, reaching 11.25 when only patients younger than 50 were considered.	8-ohdg	49-54	S100 calcium binding protein A8	Homo sapiens	19-23
12706496-9	2003	Colonic epithelium of IL10(-/-) mice with colitis showed moderate immunostaining for 8-hydroxy-2"-deoxyguanosine in the nuclei.	8-ohdg	85-112	interleukin 10	Mus musculus	22-26
12745079-4	2003	In correspondence with the change of 8-OH-dG levels, the hMTH1 mRNA levels of the physically active subjects were significantly higher than those of the sedentary subjects.	8-ohdg	37-44	nudix hydrolase 1	Homo sapiens	57-62
12745079-6	2003	Furthermore, there was a significant negative correlation between the levels of 8-OH-dG and hMTH1 mRNA.	8-ohdg	80-87	nudix hydrolase 1	Homo sapiens	92-97
12870673-12	2003	Damaged myocytes were also positive for 8-OHdG All the 3 cases of DCM positive for TRX stain showed severe left ventricular hypertrophy on electrocardiogram and highly elevated left ventricular end-diastolic pressure (> 24 mmHg), suggesting the overload of oxidative stress by hemodynamic impairment.	8-ohdg	40-46	thioredoxin	Homo sapiens	83-86
14646291-6	2003	The 8-OHdG level was significantly higher in smoking rapid acetylators than in smoking slow or intermediate acetylators, and in individuals with the UGT1A6 wild-type than in those with the UGT1A6 mutant genotype.	8-ohdg	4-10	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	149-155
14646291-6	2003	The 8-OHdG level was significantly higher in smoking rapid acetylators than in smoking slow or intermediate acetylators, and in individuals with the UGT1A6 wild-type than in those with the UGT1A6 mutant genotype.	8-ohdg	4-10	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	189-195
14646291-7	2003	Significant positive correlations between 8-OHdG and 1-OHP concentrations were found in subjects with every genotype of the CYP1A1 and CYP2E1 genes, with the GSTM1 null-type, with the NAT2 genotype of a rapid acetylator, and with the UGT1A6 wild-type, respectively.	8-ohdg	42-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	124-130
14646291-7	2003	Significant positive correlations between 8-OHdG and 1-OHP concentrations were found in subjects with every genotype of the CYP1A1 and CYP2E1 genes, with the GSTM1 null-type, with the NAT2 genotype of a rapid acetylator, and with the UGT1A6 wild-type, respectively.	8-ohdg	42-48	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	135-141
14646291-7	2003	Significant positive correlations between 8-OHdG and 1-OHP concentrations were found in subjects with every genotype of the CYP1A1 and CYP2E1 genes, with the GSTM1 null-type, with the NAT2 genotype of a rapid acetylator, and with the UGT1A6 wild-type, respectively.	8-ohdg	42-48	glutathione S-transferase mu 1	Homo sapiens	158-163
14646291-7	2003	Significant positive correlations between 8-OHdG and 1-OHP concentrations were found in subjects with every genotype of the CYP1A1 and CYP2E1 genes, with the GSTM1 null-type, with the NAT2 genotype of a rapid acetylator, and with the UGT1A6 wild-type, respectively.	8-ohdg	42-48	N-acetyltransferase 2	Homo sapiens	184-188
14646291-7	2003	Significant positive correlations between 8-OHdG and 1-OHP concentrations were found in subjects with every genotype of the CYP1A1 and CYP2E1 genes, with the GSTM1 null-type, with the NAT2 genotype of a rapid acetylator, and with the UGT1A6 wild-type, respectively.	8-ohdg	42-48	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	234-240
14646291-8	2003	The urinary 2-naphthol level significantly correlated with the 8-OHdG level only in subjects with the GSTM1 null-type.	8-ohdg	63-69	glutathione S-transferase mu 1	Homo sapiens	102-107
12686667-0	2003	Blood 8-hydroxy-2"-deoxyguanosine is associated with erythropoietin resistance in haemodialysis patients.	8-ohdg	6-33	erythropoietin	Homo sapiens	53-67
12806963-6	2003	Habitual drinkers with the ALDH2*1/*2 genotype had higher frequencies of sister-chromatid exchange in cultured lymphocytes and higher 8-OHdG levels in polymorphonuclear leukocytes than those with the ALDH2*1/*1 genotype.	8-ohdg	134-140	aldehyde dehydrogenase 2 family member	Homo sapiens	27-32
12628248-2	2003	The Escherichia coli adenine glycosylase MutY and its human homolog (hMYH) play an important role in the prevention of mutations associated with OG by removing misincorporated adenine residues from OG:A mismatches.	8-ohdg	145-147	mutY DNA glycosylase	Homo sapiens	69-73
12655006-0	2003	Influence of DNA torsional rigidity on excision of 7,8-dihydro-8-oxo-2"-deoxyguanosine in the presence of opposing abasic sites by human OGG1 protein.	8-ohdg	51-86	8-oxoguanine DNA glycosylase	Homo sapiens	137-141
12655006-1	2003	The human protein OGG1 (hOGG1) targets the highly mutagenic base 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodG) and shows a high specificity for the opposite DNA base.	8-ohdg	65-100	8-oxoguanine DNA glycosylase	Homo sapiens	18-22
12655006-1	2003	The human protein OGG1 (hOGG1) targets the highly mutagenic base 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodG) and shows a high specificity for the opposite DNA base.	8-ohdg	65-100	8-oxoguanine DNA glycosylase	Homo sapiens	24-29
12655006-1	2003	The human protein OGG1 (hOGG1) targets the highly mutagenic base 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodG) and shows a high specificity for the opposite DNA base.	8-ohdg	102-109	8-oxoguanine DNA glycosylase	Homo sapiens	18-22
12655006-1	2003	The human protein OGG1 (hOGG1) targets the highly mutagenic base 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxodG) and shows a high specificity for the opposite DNA base.	8-ohdg	102-109	8-oxoguanine DNA glycosylase	Homo sapiens	24-29
12655006-4	2003	In order to explore the role of damaged-DNA dynamics in recognition/excision by the hOGG1 repair protein, specific oligonucleotides containing an 8-oxodG opposite an abasic site, at different relative distances on the complementary strand, were synthesized.	8-ohdg	146-153	8-oxoguanine DNA glycosylase	Homo sapiens	84-89
12531391-3	2003	We examined the contents of 8-oxo-2"-deoxyguanosine (8-oxo-dG), which is a major type of oxidative damage in DNA, in the rat kidney during I/R injury, and also investigated the expression level of the OGG1 gene encoding the 8-oxoguanine DNA glycosylase.	8-ohdg	53-61	8-oxoguanine DNA glycosylase	Rattus norvegicus	201-205
12935649-7	2003	Myoglobin was also observed in 60% of 8-OH-dG-positive, in 82% of 4-HNE-positive, and in 78% of SOD-positive cases, respectively.	8-ohdg	38-45	myoglobin	Homo sapiens	0-9
12565832-4	2003	The formation of 8-hydroxy-2(")-deoxyguanosine in calf thymus DNA by peroxynitrite and SIN-1 was also significantly inhibited by SAG.	8-ohdg	17-46	MAPK associated protein 1	Homo sapiens	87-92
12663520-9	2003	Tsc-2(EK/+) rats, with lower constitutive renal OGG1 expression, experience substantially higher levels of 8-oxo-dG than do wild type Tsc-2(+/+) rats.	8-ohdg	107-115	TSC complex subunit 2	Rattus norvegicus	0-5
12663520-12	2003	Coincidentally, 8-oxo-dG levels in Tsc-2(+/+) rats 8 h after treatment with TGHQ are just 5% of those that occur in Tsc-2(EK/+) rats.	8-ohdg	16-24	TSC complex subunit 2	Rattus norvegicus	35-40
12531391-3	2003	We examined the contents of 8-oxo-2"-deoxyguanosine (8-oxo-dG), which is a major type of oxidative damage in DNA, in the rat kidney during I/R injury, and also investigated the expression level of the OGG1 gene encoding the 8-oxoguanine DNA glycosylase.	8-ohdg	53-61	8-oxoguanine DNA glycosylase	Rattus norvegicus	224-252
12531391-9	2003	Thus, the accumulation of 8-oxo-dG in the mitochondrial DNA rather than in nuclear DNA is likely to be involved in the pathogenic responses such as necrosis of renal tubular cells during I/R injury of the kidney, together with an altered level of OGG1 expression.	8-ohdg	26-34	8-oxoguanine DNA glycosylase	Rattus norvegicus	247-251
12612057-1	2003	Our previous study showed that KG-1, a human acute leukemia cell line, has mutational loss of 8-oxoguanine (8-hydroxyguanine; oh(8)Gua) glycosylase 1 (OGG1) activity and that its viability is severely affected by 8-hydroxydeoxyguanosine (8-oxodeoxyguanosine; oh(8)dG).	8-ohdg	213-236	8-oxoguanine DNA glycosylase	Homo sapiens	151-155
12612057-1	2003	Our previous study showed that KG-1, a human acute leukemia cell line, has mutational loss of 8-oxoguanine (8-hydroxyguanine; oh(8)Gua) glycosylase 1 (OGG1) activity and that its viability is severely affected by 8-hydroxydeoxyguanosine (8-oxodeoxyguanosine; oh(8)dG).	8-ohdg	238-257	8-oxoguanine DNA glycosylase	Homo sapiens	151-155
12475907-5	2003	Lipid (malondialdehyde) and DNA (8-hydroxy-2"-deoxyguanosine) peroxide levels in the hippocampus of klotho mutant mice increased at the age of 5 wk, 2 wk before the development of cognition deficits.	8-ohdg	33-61	klotho	Mus musculus	100-106
12691525-1	2003	The expression and activity of 8-oxoguanosine DNA-glycosylase (Ogg1), a key enzyme responsible forthe clearance of the oxidized DNA base 8-hydroxy-2"-deoxyguanosine (oxo8dG), was determined in the cerebellum (CB) and the caudate and the putamen (CP) of male Balb/c, ICR, and C57BL/J mice.	8-ohdg	137-164	8-oxoguanine DNA-glycosylase 1	Mus musculus	63-67
12423653-3	2002	Addition of catalase protected DNA from the gallic acid/copper-dependent strand breaks and the formation of 8-hydroxy-2"-deoxyguanosine, indicating that hydroxyl radical may participate in the DNA damage.	8-ohdg	108-135	catalase	Bos taurus	12-20
20021156-10	2003	The genotype status of GSTM1 and GSTT1 was successfully determined in all patients by analyzing an aliquot of the same DNA used for the 8-OHdG evaluation.	8-ohdg	136-142	glutathione S-transferase mu 1	Homo sapiens	23-28
20021156-10	2003	The genotype status of GSTM1 and GSTT1 was successfully determined in all patients by analyzing an aliquot of the same DNA used for the 8-OHdG evaluation.	8-ohdg	136-142	glutathione S-transferase theta 1	Homo sapiens	33-38
12127986-3	2002	The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG.	8-ohdg	66-74	transcription factor A, mitochondrial	Homo sapiens	44-49
12472901-6	2002	Removal of 8OHdG is accompanied by a spatial increase in rMYH immunoreactivity in the brain and an increase in levels of one of the three mitochondrial MYH isoforms, suggesting that inducible and non-inducible MYH isoforms exist in the brain.	8-ohdg	11-16	mutY DNA glycosylase	Rattus norvegicus	57-61
12472901-6	2002	Removal of 8OHdG is accompanied by a spatial increase in rMYH immunoreactivity in the brain and an increase in levels of one of the three mitochondrial MYH isoforms, suggesting that inducible and non-inducible MYH isoforms exist in the brain.	8-ohdg	11-16	mutY DNA glycosylase	Rattus norvegicus	58-61
12472901-6	2002	Removal of 8OHdG is accompanied by a spatial increase in rMYH immunoreactivity in the brain and an increase in levels of one of the three mitochondrial MYH isoforms, suggesting that inducible and non-inducible MYH isoforms exist in the brain.	8-ohdg	11-16	mutY DNA glycosylase	Rattus norvegicus	152-155
12067583-7	2002	Expression of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, was significantly augmented with complete loss of VDR.	8-ohdg	14-41	vitamin D receptor	Homo sapiens	136-139
12067583-7	2002	Expression of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, was significantly augmented with complete loss of VDR.	8-ohdg	43-49	vitamin D receptor	Homo sapiens	136-139
12089150-6	2002	Insofar as ROS are very reactive and inherently unstable, a more reliable method for measuring changes in their intracellular levels is to measure their damage (e.g. the accumulation of 8-hydroxy-2"-deoxyguanosine (8-OH-dG) in DNA, and oxidative protein carbonylation) or to measure the expression of an oxidative stress-induced gene, e.g. SOD1.	8-ohdg	215-222	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	340-344
12160927-2	2002	For example, 2-OH-dA and a glyoxal-dG adduct were discovered as new types of oxidative DNA damage; 2-OH-dATP was found to induce mutations and to be a good substrate of a nucleotide sanitization enzyme, the MTH1 protein; and efforts were continued to establish standard methodologies for 8-OH-dG analyses in urine and cellular DNA.	8-ohdg	288-295	nudix hydrolase 1	Homo sapiens	207-211
21782621-2	2002	Treatment of human skin fibroblasts with UVA in the presence of BaP induced cytotoxicity in a UVA- and BaP-dose-dependent manner, involving oxidative DNA damage (formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG)).	8-ohdg	175-210	prohibitin 2	Homo sapiens	64-67
21782621-2	2002	Treatment of human skin fibroblasts with UVA in the presence of BaP induced cytotoxicity in a UVA- and BaP-dose-dependent manner, involving oxidative DNA damage (formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG)).	8-ohdg	175-210	prohibitin 2	Homo sapiens	103-106
21782621-2	2002	Treatment of human skin fibroblasts with UVA in the presence of BaP induced cytotoxicity in a UVA- and BaP-dose-dependent manner, involving oxidative DNA damage (formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG)).	8-ohdg	212-220	prohibitin 2	Homo sapiens	64-67
12161006-4	2002	The data on DNA adducts, c-myc mRNA and variant estrogen receptor in patients with HCV- or HBV-related chronic liver disease are suggesting that those positive for variant liver estrogen receptor present higher genomic oxidative damage, as reflected in 8-OHdG levels.	8-ohdg	253-259	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
12127986-3	2002	The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG.	8-ohdg	81-89	transcription factor A, mitochondrial	Homo sapiens	44-49
12161006-4	2002	The data on DNA adducts, c-myc mRNA and variant estrogen receptor in patients with HCV- or HBV-related chronic liver disease are suggesting that those positive for variant liver estrogen receptor present higher genomic oxidative damage, as reflected in 8-OHdG levels.	8-ohdg	253-259	estrogen receptor 1	Homo sapiens	178-195
12127986-3	2002	The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG.	8-ohdg	81-89	transcription factor A, mitochondrial	Homo sapiens	44-49
12127986-3	2002	The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG.	8-ohdg	81-89	transcription factor A, mitochondrial	Homo sapiens	44-49
12509237-2	2002	This hypothesis was addressed by assessing the incision activity and the mRNA level of the DNA repair protein rat 8-oxodeoxyguanosine glycosylase (rOGG1) as well as the level of the oxidative stress biomarker 8-oxodeoxyguanosine (8-oxodG) in rat liver tissue before and after partial hepatectomy.	8-ohdg	114-133	8-oxoguanine DNA glycosylase	Rattus norvegicus	147-152
12106825-1	2002	The enzyme 8-oxoguanine DNA glycosylase 1 participates in the repair of damaged DNA by excising the oxidized base 8-hydroxy-2"-deoxyguanosine.	8-ohdg	114-141	8-oxoguanine DNA-glycosylase 1	Mus musculus	11-41
12117782-1	2002	The human OGG1 (hOGG1) gene encodes a DNA glycosylase that is involved in the excision repair of 8-hydroxy-2"-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA.	8-ohdg	124-131	8-oxoguanine DNA glycosylase	Homo sapiens	10-14
12117782-1	2002	The human OGG1 (hOGG1) gene encodes a DNA glycosylase that is involved in the excision repair of 8-hydroxy-2"-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA.	8-ohdg	124-131	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
12117782-8	2002	These results suggest that hOGG1 may play an important role in the repair of 8-OH-dG adducts in the aerodigestive tract and that the hOGG1 Ser326Cys polymorphism plays an important role in risk for smoking- and alcohol-related orolaryngeal cancer.	8-ohdg	77-84	8-oxoguanine DNA glycosylase	Homo sapiens	27-32
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-2	2002	Treatment of calf thymus DNA with Co(II) at 500 microM hydrogen peroxide resulted in a dose-dependent increase in 8-OHdG, which culminated at 25 microM Co(II) (62.6 modified/10(5) dG) and declined at higher Co(II) concentrations [9.6 modified/10(5) dG at 250 microM Co(II)].	8-ohdg	114-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-158
11996407-5	2002	Exposure of human diploid fibroblasts to Co(II) at 5-250 microM did not result in an increase in 8-OHdG in a dose-dependent manner, although treated cells showed significantly higher 8-OHdG levels than untreated controls (2.026 +/- 0.695 vs. 1.395 +/- 0.433 8-OHdG/10(5) dG) at all concentrations.	8-ohdg	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11996407-5	2002	Exposure of human diploid fibroblasts to Co(II) at 5-250 microM did not result in an increase in 8-OHdG in a dose-dependent manner, although treated cells showed significantly higher 8-OHdG levels than untreated controls (2.026 +/- 0.695 vs. 1.395 +/- 0.433 8-OHdG/10(5) dG) at all concentrations.	8-ohdg	183-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-47
11996407-6	2002	Our data indicate that in the presence of H2O2, Co(II) stimulates the in vitro formation of 8-OHdG.	8-ohdg	92-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
11952337-5	2002	The role of the estrogen receptor in modulating DNA damage was further established in incubations with the ER antagonist tamoxifen, where decreases in 8-oxo-deoxyguanosine were observed.	8-ohdg	151-171	estrogen receptor 1	Equus caballus	16-33
11952335-4	2002	We have shown that PCB metabolism generates ROS in vitro and in cells in culture and this leads to oxidative DNA damage, like DNA strand breaks and 8-oxo-dG formation.	8-ohdg	148-156	pyruvate carboxylase	Homo sapiens	19-22
11870126-6	2002	Patients of groups 1 and 2 with GST M1- genotype had significantly higher 8-OHdG content in sperm DNA and lower protein thiols and ascorbic acid in seminal plasma than those with GST M1+ genotype.	8-ohdg	74-80	glutathione S-transferase mu 1	Homo sapiens	32-38
11989831-10	2002	High expression of 8-OHdG was detected in 14/20 (70%) H. pylori-positive patients (13 CagA+ and 1 CagA-) and in 2/10 (20%) H. pylori-negative patients.	8-ohdg	19-25	S100 calcium binding protein A8	Homo sapiens	86-90
11989831-10	2002	High expression of 8-OHdG was detected in 14/20 (70%) H. pylori-positive patients (13 CagA+ and 1 CagA-) and in 2/10 (20%) H. pylori-negative patients.	8-ohdg	19-25	S100 calcium binding protein A8	Homo sapiens	98-102
11888709-5	2002	The concentrations of urinary 8-OH-dG were significantly elevated in the presence of the MnSOD variant genotype (P=0.04) and in the case of GSTM1 null status (P=0.02) by multivariate regression.	8-ohdg	30-37	superoxide dismutase 2	Homo sapiens	89-94
11888709-5	2002	The concentrations of urinary 8-OH-dG were significantly elevated in the presence of the MnSOD variant genotype (P=0.04) and in the case of GSTM1 null status (P=0.02) by multivariate regression.	8-ohdg	30-37	glutathione S-transferase mu 1	Homo sapiens	140-145
11841836-11	2002	Plasma TRX levels were significantly correlated with urinary excretion of 8-OHdG (P<0.005).	8-ohdg	74-80	thioredoxin	Homo sapiens	7-10
11872643-3	2002	Conspicuous elevation of 8-OHdG and apoptosis in the liver tissue were associated with reduction of the proliferating cell nuclear antigen (PCNA) index after 8 days of PB application.	8-ohdg	25-31	proliferating cell nuclear antigen	Rattus norvegicus	104-138
11872643-3	2002	Conspicuous elevation of 8-OHdG and apoptosis in the liver tissue were associated with reduction of the proliferating cell nuclear antigen (PCNA) index after 8 days of PB application.	8-ohdg	25-31	proliferating cell nuclear antigen	Rattus norvegicus	140-144
11872643-4	2002	Thereafter, 8-OHdG levels decreased with an increase in mRNA expression for the 8-OHdG repair enzyme, DNA glycosylase 1 (Ogg1).	8-ohdg	12-18	8-oxoguanine DNA glycosylase	Rattus norvegicus	121-125
11872643-4	2002	Thereafter, 8-OHdG levels decreased with an increase in mRNA expression for the 8-OHdG repair enzyme, DNA glycosylase 1 (Ogg1).	8-ohdg	80-86	8-oxoguanine DNA glycosylase	Rattus norvegicus	121-125
11872643-7	2002	Increased 8-OHdG formation is caused by developing oxidative stress or apoptotic degradation of DNA and coordinated with enhanced expression of CD1 mRNA and cell proliferation, subsequent increase of p21(WAF1/Cip1) mRNA expression, cell-cycle arrest and apoptosis, while activation of 8-OHdG repair mechanisms contributes to protection of tissue against reactive oxygen species-induced cell death.	8-ohdg	10-16	cyclin D1	Rattus norvegicus	144-147
11872643-7	2002	Increased 8-OHdG formation is caused by developing oxidative stress or apoptotic degradation of DNA and coordinated with enhanced expression of CD1 mRNA and cell proliferation, subsequent increase of p21(WAF1/Cip1) mRNA expression, cell-cycle arrest and apoptosis, while activation of 8-OHdG repair mechanisms contributes to protection of tissue against reactive oxygen species-induced cell death.	8-ohdg	10-16	KRAS proto-oncogene, GTPase	Rattus norvegicus	200-203
11872643-7	2002	Increased 8-OHdG formation is caused by developing oxidative stress or apoptotic degradation of DNA and coordinated with enhanced expression of CD1 mRNA and cell proliferation, subsequent increase of p21(WAF1/Cip1) mRNA expression, cell-cycle arrest and apoptosis, while activation of 8-OHdG repair mechanisms contributes to protection of tissue against reactive oxygen species-induced cell death.	8-ohdg	10-16	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	204-208
11872643-7	2002	Increased 8-OHdG formation is caused by developing oxidative stress or apoptotic degradation of DNA and coordinated with enhanced expression of CD1 mRNA and cell proliferation, subsequent increase of p21(WAF1/Cip1) mRNA expression, cell-cycle arrest and apoptosis, while activation of 8-OHdG repair mechanisms contributes to protection of tissue against reactive oxygen species-induced cell death.	8-ohdg	10-16	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	209-213
11841836-10	2002	By the histological examination for synovial tissue of RA patients, TRX was shown to be present on the surface of synovial lining layer as well as in the leukocytes.Moreover, urinary excretion of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage by endogenously generated oxygen radicals, was significantly higher in RA patients than in healthy subjects (11.55 +/- 4.71 versus 7.76 +/- 2.26 ng/mg creatinine, P<0.0001).	8-ohdg	196-223	thioredoxin	Homo sapiens	68-71
11841836-10	2002	By the histological examination for synovial tissue of RA patients, TRX was shown to be present on the surface of synovial lining layer as well as in the leukocytes.Moreover, urinary excretion of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage by endogenously generated oxygen radicals, was significantly higher in RA patients than in healthy subjects (11.55 +/- 4.71 versus 7.76 +/- 2.26 ng/mg creatinine, P<0.0001).	8-ohdg	225-231	thioredoxin	Homo sapiens	68-71
11927005-1	2002	The object of this study is to investigate the relationship between a typical product of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine (8OHdG), and mutagenesis in V79 cells through a molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) gene mutants.	8-ohdg	111-138	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	209-255
11927005-1	2002	The object of this study is to investigate the relationship between a typical product of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine (8OHdG), and mutagenesis in V79 cells through a molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) gene mutants.	8-ohdg	111-138	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	257-261
11927005-1	2002	The object of this study is to investigate the relationship between a typical product of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine (8OHdG), and mutagenesis in V79 cells through a molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) gene mutants.	8-ohdg	140-145	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	209-255
11927005-1	2002	The object of this study is to investigate the relationship between a typical product of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine (8OHdG), and mutagenesis in V79 cells through a molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) gene mutants.	8-ohdg	140-145	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	257-261
11872643-0	2002	Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.	8-ohdg	13-36	KRAS proto-oncogene, GTPase	Rattus norvegicus	169-172
11872643-0	2002	Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.	8-ohdg	13-36	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	173-177
11872643-0	2002	Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.	8-ohdg	13-36	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	178-182
11872643-0	2002	Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.	8-ohdg	13-36	cyclin D1	Rattus norvegicus	185-194
11872643-0	2002	Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.	8-ohdg	13-36	8-oxoguanine DNA glycosylase	Rattus norvegicus	199-203
11872643-1	2002	To evaluate the risk of exposure to so-called non-genotoxic chemicals and elucidate mechanisms underlying their promoting activity on rat liver carcinogenesis the formation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), cytochrome P-450 (P-450) and hydroxyl radicals induction, DNA repair and alteration to cellular proliferation and apoptosis in the rat liver were investigated during 2 weeks of phenobarbital (PB) administration at a dose of 0.05%.	8-ohdg	205-211	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	214-230
11911490-5	2002	Since human 8-oxoguanine DNA glycosylase 1 (hOGG1) was a repair enzyme for removing 8- OH dG from damaged DNA, we hypothesized that hOGG1 mRNA may be used to assess the risk of oxidative damage induced by the exposure of COF.	8-ohdg	84-92	8-oxoguanine DNA glycosylase	Homo sapiens	44-49
11911490-5	2002	Since human 8-oxoguanine DNA glycosylase 1 (hOGG1) was a repair enzyme for removing 8- OH dG from damaged DNA, we hypothesized that hOGG1 mRNA may be used to assess the risk of oxidative damage induced by the exposure of COF.	8-ohdg	84-92	8-oxoguanine DNA glycosylase	Homo sapiens	132-137
11739311-7	2001	LOX-1 overexpression induced activation of p38 mitogen-activated protein kinase (MAPK) and oxidative stress in cardiac myocytes, as demonstrated by an increase in positive immunostaining for 8-hydroxy-2"-deoxyguanosine.	8-ohdg	191-218	oxidized low density lipoprotein receptor 1	Rattus norvegicus	0-5
11772884-6	2002	In AM(+/-) mice, Ang II/salt loading increased both urinary excretion of 8-hydroxydeoxyguanosine and isoprostane, markers of oxidative stress.	8-ohdg	73-96	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	17-23
11536371-7	2001	Cases also had a significantly higher level of 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase (hOGG1) protein expression in normal breast tissues than controls (P = 0.008).	8-ohdg	47-73	8-oxoguanine DNA glycosylase	Homo sapiens	106-111
11751424-11	2001	This study also determined the level of 8-hydroxydeoxyguanosine (8-OH-dGua), an indicator for oxidative DNA lesions in IL-6-treated or mcl-1-overexpressed AGS cells after treatment with H(2)O(2).	8-ohdg	40-63	interleukin 6	Homo sapiens	119-123
11705706-6	2001	The objective of this study was to determine the effects of dieldrin exposure on the activity of the enzyme responsible for removing 8-oxodGuo, OGG1, from undifferentiated (untreated with NGF) and differentiated (NGF-treated) PC 12 cells.	8-ohdg	133-142	8-oxoguanine DNA glycosylase	Rattus norvegicus	144-148
11675410-0	2001	Effect of human OGG1 1245C-->G gene polymorphism on 8-hydroxy-2"-deoxyguanosine levels of leukocyte DNA among patients undergoing chronic hemodialysis.	8-ohdg	55-82	8-oxoguanine DNA glycosylase	Homo sapiens	16-20
11675410-1	2001	The effects of the human OGG1 gene (hOGG1) 1245C-->G polymorphism on the 8-hydroxy-2"-deoxyguanosine (8-OHdG) contents of peripheral leukocyte DNA were investigated among chronic hemodialysis patients.	8-ohdg	76-103	8-oxoguanine DNA glycosylase	Homo sapiens	25-29
11675410-1	2001	The effects of the human OGG1 gene (hOGG1) 1245C-->G polymorphism on the 8-hydroxy-2"-deoxyguanosine (8-OHdG) contents of peripheral leukocyte DNA were investigated among chronic hemodialysis patients.	8-ohdg	76-103	8-oxoguanine DNA glycosylase	Homo sapiens	36-41
11675410-1	2001	The effects of the human OGG1 gene (hOGG1) 1245C-->G polymorphism on the 8-hydroxy-2"-deoxyguanosine (8-OHdG) contents of peripheral leukocyte DNA were investigated among chronic hemodialysis patients.	8-ohdg	105-111	8-oxoguanine DNA glycosylase	Homo sapiens	25-29
11675410-1	2001	The effects of the human OGG1 gene (hOGG1) 1245C-->G polymorphism on the 8-hydroxy-2"-deoxyguanosine (8-OHdG) contents of peripheral leukocyte DNA were investigated among chronic hemodialysis patients.	8-ohdg	105-111	8-oxoguanine DNA glycosylase	Homo sapiens	36-41
11675410-10	2001	The multivariate regression analysis revealed that hOGG1 1245C-->G polymorphism and dialysis membrane type were the two independent predictors of 8-OHdG contents in leukocyte DNA from hemodialysis patients.	8-ohdg	149-155	8-oxoguanine DNA glycosylase	Homo sapiens	51-56
11559029-2	2001	As several recent studies have shown that various oxidizing agents including peroxynitrite and singlet oxygen react readily with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) to yield further oxidized products, we have studied the reaction of 8-oxodGuo with reagent HOCl and with a myeloperoxidase-H(2)O(2)-Cl(-) system.	8-ohdg	129-164	myeloperoxidase	Homo sapiens	284-299
11559029-2	2001	As several recent studies have shown that various oxidizing agents including peroxynitrite and singlet oxygen react readily with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) to yield further oxidized products, we have studied the reaction of 8-oxodGuo with reagent HOCl and with a myeloperoxidase-H(2)O(2)-Cl(-) system.	8-ohdg	166-175	myeloperoxidase	Homo sapiens	284-299
11559029-2	2001	As several recent studies have shown that various oxidizing agents including peroxynitrite and singlet oxygen react readily with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) to yield further oxidized products, we have studied the reaction of 8-oxodGuo with reagent HOCl and with a myeloperoxidase-H(2)O(2)-Cl(-) system.	8-ohdg	245-254	myeloperoxidase	Homo sapiens	284-299
11559029-8	2001	dSph was also formed by reaction of 8-oxodGuo with myeloperoxidase in the presence of H(2)O(2) and Cl(-).	8-ohdg	36-45	myeloperoxidase	Homo sapiens	51-66
11559029-9	2001	Our results suggest that formation of dSph from 8-oxodGuo is mediated, possibly via an addition of Cl(+) to, or two-electron oxidation of 8-oxodGuo, with HOCl or the myeloperoxidase-H(2)O(2)-Cl(-) system.	8-ohdg	48-57	myeloperoxidase	Homo sapiens	166-181
11873865-3	2001	Significant correlations between 8-OHdG and FT4, and cytochrome c were found.	8-ohdg	33-39	cytochrome c, somatic	Homo sapiens	53-65
11606384-4	2001	We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels.	8-ohdg	356-383	catechol-O-methyltransferase	Homo sapiens	52-56
11606384-4	2001	We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels.	8-ohdg	356-383	catechol-O-methyltransferase	Homo sapiens	109-113
11606384-4	2001	We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels.	8-ohdg	356-383	catechol-O-methyltransferase	Homo sapiens	109-113
11606384-4	2001	We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels.	8-ohdg	385-393	catechol-O-methyltransferase	Homo sapiens	52-56
11606384-4	2001	We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels.	8-ohdg	385-393	catechol-O-methyltransferase	Homo sapiens	109-113
11606384-4	2001	We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels.	8-ohdg	385-393	catechol-O-methyltransferase	Homo sapiens	109-113
11404242-7	2001	The levels of thiobarbituric acid-reactive substances and 8-hydroxy-2"-deoxyguanosine in the lung tissue of CFTR-KO mice were significantly increased compared with those in WT mice.	8-ohdg	58-85	cystic fibrosis transmembrane conductance regulator	Mus musculus	108-112
11437637-7	2001	Importantly, severe hyperplasia and accumulation of the oxidative DNA adduct 8-hydroxydeoxyguanosine were observed in the bronchial epidermis of nrf2(-/-) mice following DE exposure.	8-ohdg	77-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
11454679-0	2001	Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.	8-ohdg	10-29	8-oxoguanine DNA-glycosylase 1	Mus musculus	102-106
11454679-0	2001	Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.	8-ohdg	10-29	8-oxoguanine DNA-glycosylase 1	Mus musculus	170-174
11454679-3	2001	The main pathway for the repair of 8-oxodG is the base excision repair pathway initiated by oxoguanine DNA glycosylase (OGG1).	8-ohdg	35-42	8-oxoguanine DNA-glycosylase 1	Mus musculus	120-124
11454679-6	2001	Using mouse liver mitochondria isolated from ogg1(-/-) mice, we showed that the OGG1 gene encodes for the mitochondrial 8-oxodG glycosylase because these extracts have no incision activity toward an oligonucleotide containing a single 8-oxodG DNA base lesion.	8-ohdg	120-127	8-oxoguanine DNA-glycosylase 1	Mus musculus	45-49
11454679-6	2001	Using mouse liver mitochondria isolated from ogg1(-/-) mice, we showed that the OGG1 gene encodes for the mitochondrial 8-oxodG glycosylase because these extracts have no incision activity toward an oligonucleotide containing a single 8-oxodG DNA base lesion.	8-ohdg	120-127	8-oxoguanine DNA-glycosylase 1	Mus musculus	80-84
11454679-7	2001	Consistent with an important role for the OGG1 protein in the removal of 8-oxodG from the mitochondrial genome, we found that mtDNA isolated from liver from OGG1-null mutant animals contained 20-fold more 8-oxodG than mtDNA from wild-type animals.	8-ohdg	73-80	8-oxoguanine DNA-glycosylase 1	Mus musculus	42-46
11454679-7	2001	Consistent with an important role for the OGG1 protein in the removal of 8-oxodG from the mitochondrial genome, we found that mtDNA isolated from liver from OGG1-null mutant animals contained 20-fold more 8-oxodG than mtDNA from wild-type animals.	8-ohdg	73-80	8-oxoguanine DNA-glycosylase 1	Mus musculus	157-161
11454679-7	2001	Consistent with an important role for the OGG1 protein in the removal of 8-oxodG from the mitochondrial genome, we found that mtDNA isolated from liver from OGG1-null mutant animals contained 20-fold more 8-oxodG than mtDNA from wild-type animals.	8-ohdg	205-212	8-oxoguanine DNA-glycosylase 1	Mus musculus	42-46
11454679-7	2001	Consistent with an important role for the OGG1 protein in the removal of 8-oxodG from the mitochondrial genome, we found that mtDNA isolated from liver from OGG1-null mutant animals contained 20-fold more 8-oxodG than mtDNA from wild-type animals.	8-ohdg	205-212	8-oxoguanine DNA-glycosylase 1	Mus musculus	157-161
11453735-11	2001	Treatment of the particles with metal ion chelator before reacting with DNA or addition of catalase in the incubation mixture, suppressed 8-oxo-dG formation significantly (p < 0.05) in oil-derived fly ash particles only.	8-ohdg	138-146	Catalase	Drosophila melanogaster	91-99
11506893-1	2001	Ceruloplasmin (Cp) was found to promote the oxidative damage to DNA in vitro, as evidenced by the formation of 8-hydroxy-2"-deoxyguanosine and strand breaks, when incubated with a cysteine metal-catalyzed oxidation system (Cys-MCO) comprised of Fe(3+), O(2), and cysteine as an electron donor.	8-ohdg	111-138	ceruloplasmin	Homo sapiens	0-13
11296483-2	2001	8-Oxo-2"-deoxyguanosine (8-oxo-dG) is a major oxidative DNA damage product that can result in mutation, and hMTH1, human MutT homolog protein 1, has been identified as an enzyme that hydrolyzes 8-oxo-dGTP to the monophosphate, thus preventing accumulation of 8-oxo-dG in DNA.	8-ohdg	0-23	nudix hydrolase 1	Homo sapiens	108-113
11320156-3	2001	The analysis of 8-hydroxy-2"-deoxyguanosine (8-OHdG) content in the DNA of untreated cells showed an increased basal level of damage in cells from the complementation groups FA-C and FA-E.	8-ohdg	16-43	FA complementation group C	Homo sapiens	174-178
11320156-3	2001	The analysis of 8-hydroxy-2"-deoxyguanosine (8-OHdG) content in the DNA of untreated cells showed an increased basal level of damage in cells from the complementation groups FA-C and FA-E.	8-ohdg	16-43	FA complementation group E	Homo sapiens	183-187
11320156-3	2001	The analysis of 8-hydroxy-2"-deoxyguanosine (8-OHdG) content in the DNA of untreated cells showed an increased basal level of damage in cells from the complementation groups FA-C and FA-E.	8-ohdg	45-51	FA complementation group C	Homo sapiens	174-178
11320156-3	2001	The analysis of 8-hydroxy-2"-deoxyguanosine (8-OHdG) content in the DNA of untreated cells showed an increased basal level of damage in cells from the complementation groups FA-C and FA-E.	8-ohdg	45-51	FA complementation group E	Homo sapiens	183-187
11409938-8	2001	Experiments with 32P-labeled DNA fragments obtained from the human p53 tumor suppressor gene and the c-Ha-ras-1 protooncogene suggested that KBrO3 induced 8-oxodG formation at 5"-site guanine of GG and GGG sequences of double-stranded DNA in the presence of GSH and that treatment of formamidopyrimidine-DNA glycosylase led to chain cleavages at the guanine residues.	8-ohdg	155-162	HRas proto-oncogene, GTPase	Homo sapiens	101-111
11304122-4	2001	When DNA or nucleosides were incubated with COX-2 and arachidonic acid, a significant increase in the amount of 8-oxo-2"-deoxyguanosine was observed.	8-ohdg	112-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11275476-6	2001	4-ABP(NHOH) dose-dependently induced 8-hydroxy-2"-deoxyguanosine (8-OHdG) formation in the presence of Cu(ll) and NADH.	8-ohdg	37-64	amine oxidase copper containing 1	Homo sapiens	2-5
11275476-6	2001	4-ABP(NHOH) dose-dependently induced 8-hydroxy-2"-deoxyguanosine (8-OHdG) formation in the presence of Cu(ll) and NADH.	8-ohdg	66-72	amine oxidase copper containing 1	Homo sapiens	2-5
11275476-8	2001	Increased amounts of 8-OHdG were found in HL-60 cells compared to the H(2)O(2)-resistant clone HP100 following 4-ABP(NHOH) treatment, further supporting the involvement of H(2)O(2).	8-ohdg	21-27	amine oxidase copper containing 1	Homo sapiens	113-116
11296483-2	2001	8-Oxo-2"-deoxyguanosine (8-oxo-dG) is a major oxidative DNA damage product that can result in mutation, and hMTH1, human MutT homolog protein 1, has been identified as an enzyme that hydrolyzes 8-oxo-dGTP to the monophosphate, thus preventing accumulation of 8-oxo-dG in DNA.	8-ohdg	25-33	nudix hydrolase 1	Homo sapiens	108-113
11296483-2	2001	8-Oxo-2"-deoxyguanosine (8-oxo-dG) is a major oxidative DNA damage product that can result in mutation, and hMTH1, human MutT homolog protein 1, has been identified as an enzyme that hydrolyzes 8-oxo-dGTP to the monophosphate, thus preventing accumulation of 8-oxo-dG in DNA.	8-ohdg	194-202	nudix hydrolase 1	Homo sapiens	108-113
11248442-3	2001	Thirty minutes after ischemia-reperfusion, the intensities of both NR and 8-hydroxy-2"-deoxyguanosine (8-OHdG) immunoreactivities were markedly increased in neurons of CA1.	8-ohdg	74-101	carbonic anhydrase 1	Homo sapiens	168-171
11248442-3	2001	Thirty minutes after ischemia-reperfusion, the intensities of both NR and 8-hydroxy-2"-deoxyguanosine (8-OHdG) immunoreactivities were markedly increased in neurons of CA1.	8-ohdg	103-109	carbonic anhydrase 1	Homo sapiens	168-171
11248442-4	2001	However, NR2A/B and 8-OHdG immunoreactivities were enhanced in CA1 over 24 h after ischemia although NR1 immunoreactivity was decreased.	8-ohdg	20-26	carbonic anhydrase 1	Homo sapiens	63-66
11132608-5	2000	Cellular degeneration induced by AGEs was characterized in terms of intracellular oxidant levels, intracellular total glutathione (GSH) levels, mRNA expression for gamma-glutamylcysteine synthetase (GCS), and a new marker of oxidative stress, 8-hydroxy-2"-deoxyguanosine (8-OHdG) contents.	8-ohdg	243-270	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	199-202
11258973-8	2001	The rate constant of 8-oxo-dG oxidation (k(12)) by the (*)NO2 one-electron oxidant (the (*)NO2/NO2(-) redox potential, E degrees approximately 1.04 V vs NHE) is lower than k(12) for a series of oxidizing aromatic radical cations with known redox potentials.	8-ohdg	21-29	solute carrier family 9 member C1	Homo sapiens	153-156
11258973-9	2001	The k(12) values for 8-oxo-dG oxidation by different aromatic radical cations derived from the photoionization of their parent compounds depend on the redox potentials of the latter, which were in the range of 0.8-1.6 V versus NHE.	8-ohdg	21-29	solute carrier family 9 member C1	Homo sapiens	227-230
11718997-4	2001	In the aged-impaired group, immunoreactivity to 8-hydroxy-2"-deoxyguanosine, an oxidative nucleic acid adduct, was found to be elevated in the dentate gyrus and in area CA1 of the hippocampal formation.	8-ohdg	48-75	carbonic anhydrase 1	Rattus norvegicus	169-172
11327625-9	2001	Hyperglycemia related to insulin resistance in hypertension in Tanzania is associated with increased urinary 8-OHdG.	8-ohdg	109-115	insulin	Homo sapiens	25-32
11162561-1	2001	We have used human single chain Fv (scFv) phage display antibody libraries to isolate recombinant antibodies against the DNA adduct 8-oxo-2"-deoxyguanosine (8-oxodG).	8-ohdg	132-155	immunglobulin heavy chain variable region	Homo sapiens	36-40
11162561-1	2001	We have used human single chain Fv (scFv) phage display antibody libraries to isolate recombinant antibodies against the DNA adduct 8-oxo-2"-deoxyguanosine (8-oxodG).	8-ohdg	157-164	immunglobulin heavy chain variable region	Homo sapiens	36-40
11162561-6	2001	The use of human scFv phage display libraries has thus produced a unique reagent with specificity for 8-oxodG, which may have a role in damage detection and quantitation and in modifying DNA repair activity.	8-ohdg	102-109	immunglobulin heavy chain variable region	Homo sapiens	17-21
11132608-5	2000	Cellular degeneration induced by AGEs was characterized in terms of intracellular oxidant levels, intracellular total glutathione (GSH) levels, mRNA expression for gamma-glutamylcysteine synthetase (GCS), and a new marker of oxidative stress, 8-hydroxy-2"-deoxyguanosine (8-OHdG) contents.	8-ohdg	272-278	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	199-202
11002420-0	2000	Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1.	8-ohdg	91-114	8-oxoguanine DNA glycosylase	Homo sapiens	50-55
11002420-5	2000	Using KG-1 with impaired hOGG1, we demonstrated cytotoxicity of 8ohdG probably due to its incorporation into cellular DNA.	8-ohdg	64-69	8-oxoguanine DNA glycosylase	Homo sapiens	25-30
10814876-6	2000	HC also increased 8-hydroxy-2"-deoxyguanosine formation and apoptosis in BSO-pretreated HepG2 cells and this increase could also be suppressed by catalase.	8-ohdg	18-45	catalase	Homo sapiens	146-154
10916104-9	2000	The leukocyte 8-OHdG level correlated negatively with plasma alpha-tocopherol and blood lipid-adjusted plasma alpha-tocopherol, but correlated positively with serum iron and percentage of transferrin saturation.	8-ohdg	14-20	transferrin	Homo sapiens	188-199
10956030-0	2000	Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells.	8-ohdg	20-51	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	73-96
10956030-1	2000	The repair of the endogenous lesion 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG) was investigated in the nucleotide excision repair mutant xeroderma pigmentosum D (XPD), using human normal or transformed XPD fibroblasts and the Chinese hamster XPD cell line UV5.	8-ohdg	36-67	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	136-159
10956030-1	2000	The repair of the endogenous lesion 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG) was investigated in the nucleotide excision repair mutant xeroderma pigmentosum D (XPD), using human normal or transformed XPD fibroblasts and the Chinese hamster XPD cell line UV5.	8-ohdg	36-67	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	161-164
10956030-1	2000	The repair of the endogenous lesion 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG) was investigated in the nucleotide excision repair mutant xeroderma pigmentosum D (XPD), using human normal or transformed XPD fibroblasts and the Chinese hamster XPD cell line UV5.	8-ohdg	69-76	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	136-159
10956030-1	2000	The repair of the endogenous lesion 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG) was investigated in the nucleotide excision repair mutant xeroderma pigmentosum D (XPD), using human normal or transformed XPD fibroblasts and the Chinese hamster XPD cell line UV5.	8-ohdg	69-76	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	161-164
10956030-1	2000	The repair of the endogenous lesion 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG) was investigated in the nucleotide excision repair mutant xeroderma pigmentosum D (XPD), using human normal or transformed XPD fibroblasts and the Chinese hamster XPD cell line UV5.	8-ohdg	69-76	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	201-204
10956030-1	2000	The repair of the endogenous lesion 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG) was investigated in the nucleotide excision repair mutant xeroderma pigmentosum D (XPD), using human normal or transformed XPD fibroblasts and the Chinese hamster XPD cell line UV5.	8-ohdg	69-76	general transcription and DNA repair factor IIH helicase subunit XPD	Cricetulus griseus	201-204
10956030-4	2000	Repair of 8-oxodG was even slightly (2-3-fold) but reproducibly increased in Chinese hamster XPD mutant UV5 cells, as compared to parental AA8 cells.	8-ohdg	10-17	general transcription and DNA repair factor IIH helicase subunit XPD	Cricetulus griseus	93-96
10826924-1	2000	Ceruloplasmin (Cp) was found to promote the oxidative damage to DNA, as evidenced by the formation of 8-hydroxy-2"-deoxyguanosine and strand breaks, when incubated with H2O2 in vitro.	8-ohdg	102-129	ceruloplasmin	Homo sapiens	0-13
10833429-5	2000	In contrast, in response to menadione-mediated oxidative stress, induction of 8-oxo-dG and DNA strand breaks was much lower in the GPx1-proficient mitochondria (e.g., +14% 8-oxo-dG versus +54% in Hygro-3 after 1-h exposure to 25 microM menadione, P < 0.05).	8-ohdg	78-86	glutathione peroxidase 1	Homo sapiens	131-135
10833429-5	2000	In contrast, in response to menadione-mediated oxidative stress, induction of 8-oxo-dG and DNA strand breaks was much lower in the GPx1-proficient mitochondria (e.g., +14% 8-oxo-dG versus +54% in Hygro-3 after 1-h exposure to 25 microM menadione, P < 0.05).	8-ohdg	172-180	glutathione peroxidase 1	Homo sapiens	131-135
10778969-7	2000	It was found that 8-OHdG-specific lyase activity and hOGG1 expression were significantly up-regulated in carcinoma, and a proportional association between 8-OHdG levels and either 8-OHdG lyase activity (r = 0.641, P < 0.05) or hOGG1 expression (r = 0.702, P < 0.05) was present.	8-ohdg	18-24	8-oxoguanine DNA glycosylase	Homo sapiens	230-235
10810125-10	2000	However, the subjects carrying the CYP2E1 mutant type excreted higher concentrations of 8-OH-dG and there was a marginally significant interaction of GSTT1 with firefighting activity.	8-ohdg	88-95	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	35-41
10783320-0	2000	The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats.	8-ohdg	57-81	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	4-9
10783320-4	2000	The aim of this study was to test the effect of nimesulide, a preferential COX-2 inhibitor, on the DSS-induced 8-oxodGuo increase.	8-ohdg	111-120	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	75-80
10766427-0	2000	Increased formation of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes.	8-ohdg	45-72	glutathione S-transferase pi 1	Homo sapiens	128-133
10766427-0	2000	Increased formation of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes.	8-ohdg	45-72	catechol-O-methyltransferase	Homo sapiens	138-142
10766427-10	2000	Furthermore, patients with genotype of high GSTP1 activity had lower level of 8-OHdG in DNA of breast cancer tissues than others.	8-ohdg	78-84	glutathione S-transferase pi 1	Homo sapiens	44-49
10766427-11	2000	On the contrary, the mean level of 8-OHdG in DNA of breast cancer tissues was higher among patients with genotype of high COMT activity.	8-ohdg	35-41	catechol-O-methyltransferase	Homo sapiens	122-126
10821140-7	2000	The 24-h urinary 8-OHdG of the hypertensive subjects (SBP > or =140 mmHg and/or DBP > or =90 mmHg) was significantly (p < 0.05) higher than that of the normotensive subjects (SBP <140 mmHg and DBP <90 mmHg) after adjusting for age and gender (Hypertensives: 17.31 +/- 2.0 ng/mg creatinine, n=38; Normotensives: 10.10 +/- 2.64 ng/mg creatinine, n=22).	8-ohdg	17-23	spermine binding protein	Rattus norvegicus	54-57
10821140-7	2000	The 24-h urinary 8-OHdG of the hypertensive subjects (SBP > or =140 mmHg and/or DBP > or =90 mmHg) was significantly (p < 0.05) higher than that of the normotensive subjects (SBP <140 mmHg and DBP <90 mmHg) after adjusting for age and gender (Hypertensives: 17.31 +/- 2.0 ng/mg creatinine, n=38; Normotensives: 10.10 +/- 2.64 ng/mg creatinine, n=22).	8-ohdg	17-23	D-box binding PAR bZIP transcription factor	Rattus norvegicus	83-86
10821140-7	2000	The 24-h urinary 8-OHdG of the hypertensive subjects (SBP > or =140 mmHg and/or DBP > or =90 mmHg) was significantly (p < 0.05) higher than that of the normotensive subjects (SBP <140 mmHg and DBP <90 mmHg) after adjusting for age and gender (Hypertensives: 17.31 +/- 2.0 ng/mg creatinine, n=38; Normotensives: 10.10 +/- 2.64 ng/mg creatinine, n=22).	8-ohdg	17-23	spermine binding protein	Rattus norvegicus	184-187
10821140-7	2000	The 24-h urinary 8-OHdG of the hypertensive subjects (SBP > or =140 mmHg and/or DBP > or =90 mmHg) was significantly (p < 0.05) higher than that of the normotensive subjects (SBP <140 mmHg and DBP <90 mmHg) after adjusting for age and gender (Hypertensives: 17.31 +/- 2.0 ng/mg creatinine, n=38; Normotensives: 10.10 +/- 2.64 ng/mg creatinine, n=22).	8-ohdg	17-23	D-box binding PAR bZIP transcription factor	Rattus norvegicus	205-208
10775419-7	2000	The average renal excretion of oxo(8)dG (pmol/day/kg weight) was significantly (P < 0.025) on average 13% higher in CSP (375.5 +/- 27.7) than in BP (333.2 +/- 47.	8-ohdg	31-39	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	119-122
10775419-9	2000	Maximum increase in oxo(8)dG excretion of on average 17% was on the third to fifth day of the CSP.	8-ohdg	20-28	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	94-97
10830871-10	2000	8-Oxo-dGTPase inhibition was accompanied by an increase in the 8-oxo-dG level in testicular DNA.	8-ohdg	63-71	nudix hydrolase 1	Rattus norvegicus	0-13
10741853-4	2000	Two enzymic hydrolysis regimes (DNase I, phosphodiesterases I and II, and alkaline phosphatase; or P1 nuclease and alkaline phosphatase) give similar values for 8-oxodG.	8-ohdg	161-168	deoxyribonuclease 1	Bos taurus	32-68
10693941-3	2000	We found that the OGG activity in nuclear extracts, under the condition in which other nucleases did not destroy the oligodeoxynucleotide duplex, excised oh8dG with the greatest efficiency on the oligodeoxynucleotide duplex containing oh8dG/dC and with less efficiency on the heteroduplex containing oh8dG/dT, oh8dG/dG, or oh8dG/dA.	8-ohdg	154-159	8-oxoguanine DNA-glycosylase 1	Mus musculus	18-21
10802231-8	2000	In control experiments, Fab 166 was incubated with 200 microM purified 8-oxodG or with formamidopyrimidine DNA-glycosylase (Fpg) to remove 8-oxoG lesions in DNA.	8-ohdg	71-78	FA complementation group B	Homo sapiens	24-27
10693941-3	2000	We found that the OGG activity in nuclear extracts, under the condition in which other nucleases did not destroy the oligodeoxynucleotide duplex, excised oh8dG with the greatest efficiency on the oligodeoxynucleotide duplex containing oh8dG/dC and with less efficiency on the heteroduplex containing oh8dG/dT, oh8dG/dG, or oh8dG/dA.	8-ohdg	235-240	8-oxoguanine DNA-glycosylase 1	Mus musculus	18-21
10693941-3	2000	We found that the OGG activity in nuclear extracts, under the condition in which other nucleases did not destroy the oligodeoxynucleotide duplex, excised oh8dG with the greatest efficiency on the oligodeoxynucleotide duplex containing oh8dG/dC and with less efficiency on the heteroduplex containing oh8dG/dT, oh8dG/dG, or oh8dG/dA.	8-ohdg	235-240	8-oxoguanine DNA-glycosylase 1	Mus musculus	18-21
10693941-3	2000	We found that the OGG activity in nuclear extracts, under the condition in which other nucleases did not destroy the oligodeoxynucleotide duplex, excised oh8dG with the greatest efficiency on the oligodeoxynucleotide duplex containing oh8dG/dC and with less efficiency on the heteroduplex containing oh8dG/dT, oh8dG/dG, or oh8dG/dA.	8-ohdg	235-240	8-oxoguanine DNA-glycosylase 1	Mus musculus	18-21
10693941-3	2000	We found that the OGG activity in nuclear extracts, under the condition in which other nucleases did not destroy the oligodeoxynucleotide duplex, excised oh8dG with the greatest efficiency on the oligodeoxynucleotide duplex containing oh8dG/dC and with less efficiency on the heteroduplex containing oh8dG/dT, oh8dG/dG, or oh8dG/dA.	8-ohdg	235-240	8-oxoguanine DNA-glycosylase 1	Mus musculus	18-21
10693941-7	2000	The data suggest a possibility that the OGG1 protein may excise oh8dG in the mouse brain and that the activity of OGG1 may have a functional role in reducing oxidative gene damage in the brain after FblR.	8-ohdg	64-69	8-oxoguanine DNA-glycosylase 1	Mus musculus	40-44
10657953-7	2000	In conclusion, tumours with 3p LOH at loci associated with hOGG1 and GPX1 appear to have compromised oxidative defence mechanisms as measured by reduced GPX1 enzyme activity and elevated 8-OHdG levels and this may affect the prognosis of lung cancer patients.	8-ohdg	187-193	8-oxoguanine DNA glycosylase	Homo sapiens	59-64
10657953-7	2000	In conclusion, tumours with 3p LOH at loci associated with hOGG1 and GPX1 appear to have compromised oxidative defence mechanisms as measured by reduced GPX1 enzyme activity and elevated 8-OHdG levels and this may affect the prognosis of lung cancer patients.	8-ohdg	187-193	glutathione peroxidase 1	Homo sapiens	69-73
10657953-1	2000	Polymorphic genes for the peroxide scavenger glutathione peroxidase I (GPX1) and 8-hydroxydeoxyguanosine (8-OHdG) DNA glycosylase/apurinic (AP) lyase (hOGG1) map to loci on chromosome 3p which are subject to frequent loss of heterozygosity (LOH) in lung tumours.	8-ohdg	106-112	8-oxoguanine DNA glycosylase	Homo sapiens	151-156
10657971-7	2000	P2N also resulted in the formation of 8-aminodeoxyguanosine and increased the level of 8-oxodeoxyguanosine in V79-hP-PST cells, but not in the parental V79-MZ cells, which do not show any sulfotransferase activity.	8-ohdg	87-106	sulfotransferase family 1A member 1	Homo sapiens	117-120
10426816-1	1999	8-Oxo-2"-deoxyguanosine 5"-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) is an enzyme which prevents incorporation into DNA of promutagenic 8-oxo-2"-deoxyguanosine (8-oxo-dG) from a deoxynucleotide pool damaged by endogenous oxidants.	8-ohdg	0-23	nudix hydrolase 1	Rattus norvegicus	62-75
10589547-2	1999	We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8-deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients.	8-ohdg	40-48	nudix hydrolase 1	Homo sapiens	55-102
10589547-2	1999	We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8-deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients.	8-ohdg	40-48	nudix hydrolase 1	Homo sapiens	104-109
10525278-9	1999	Catalase or heat-denatured catalase partially protected the formation of 8-OHdG adducts induced by Cr(VI)/ascorbate, suggesting an effect of proteins.	8-ohdg	73-79	catalase	Homo sapiens	0-8
10525278-9	1999	Catalase or heat-denatured catalase partially protected the formation of 8-OHdG adducts induced by Cr(VI)/ascorbate, suggesting an effect of proteins.	8-ohdg	73-79	catalase	Homo sapiens	27-35
10426816-1	1999	8-Oxo-2"-deoxyguanosine 5"-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) is an enzyme which prevents incorporation into DNA of promutagenic 8-oxo-2"-deoxyguanosine (8-oxo-dG) from a deoxynucleotide pool damaged by endogenous oxidants.	8-ohdg	144-167	nudix hydrolase 1	Rattus norvegicus	62-75
10490241-7	1999	The ratio of SSB/8-OHdG catalyzed by chelated iron, which is twice as high as by unchelated iron, indicates that chelation affects iron-catalyzed oxidative DNA damage in a specific way favoring strand breakage over base modification.	8-ohdg	17-23	small RNA binding exonuclease protection factor La	Homo sapiens	13-16
10443924-0	1999	Higher activity of 8-oxo-2"-deoxyguanosine 5"-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) coincides with lower background levels of 8-oxo-2"-deoxyguanosine in DNA of fetal compared with maternal mouse organs.	8-ohdg	19-42	nudix (nucleoside diphosphate linked moiety X)-type motif 1	Mus musculus	81-94
10454620-5	1999	Our results indicate that whereas a single 8-oxodG was sufficient to inhibit transcription factor binding to AP-1 and Sp1 sequences it had no effect on binding to NF-kappaB, regardless of its position.	8-ohdg	43-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-113
10415406-6	1999	The level of 8-OHdG in CA1 increased significantly (P<0.05) at the end of 30 min after ischemia, but there was no increase within CA2 and CA3 areas.	8-ohdg	13-19	carbonic anhydrase 1	Homo sapiens	23-26
10443924-1	1999	Mammalian homologues of Escherichia coli MutT, a protein having 8-oxo-2"-deoxyguanosine 5"-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity, are thought to play the same role in preventing the incorporation of promutagenic 8-oxo-2"-deoxyguanosine (8-oxo-dG) into DNA.	8-ohdg	64-87	nudix hydrolase 1	Homo sapiens	126-139
10443924-1	1999	Mammalian homologues of Escherichia coli MutT, a protein having 8-oxo-2"-deoxyguanosine 5"-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity, are thought to play the same role in preventing the incorporation of promutagenic 8-oxo-2"-deoxyguanosine (8-oxo-dG) into DNA.	8-ohdg	126-134	nudix (nucleoside diphosphate linked moiety X)-type motif 1	Mus musculus	64-124
10378449-7	1999	In the presence of either NAC (1 mM) or antioxidant enzymes (10 u/ml SOD and 10 u/ml CAT), oh8dG levels returned to the corresponding control levels.	8-ohdg	91-96	X-linked Kx blood group	Homo sapiens	26-29
10480377-4	1999	We have studied the association between the PON genotypes and the urinary excretion of 8-OHdG.	8-ohdg	87-93	paraoxonase 1	Homo sapiens	44-47
10336498-1	1999	8-oxo-7, 8-dihydro-2"-deoxyguanosine causes base substitution errors at neighboring template sites when copied by DNA polymerase beta.	8-ohdg	0-36	DNA polymerase beta	Homo sapiens	114-133
10336498-6	1999	Error rates at sites adjacent to 8-oxo-dG were roughly 1% of the values opposite 8-oxo-dG, potentially generating tandem mutations during in vivo short-gap repair synthesis by pol beta.	8-ohdg	33-41	DNA polymerase beta	Homo sapiens	176-184
10336498-6	1999	Error rates at sites adjacent to 8-oxo-dG were roughly 1% of the values opposite 8-oxo-dG, potentially generating tandem mutations during in vivo short-gap repair synthesis by pol beta.	8-ohdg	81-89	DNA polymerase beta	Homo sapiens	176-184
10220568-6	1999	This study also determines the level of 8-hydroxydeoxyguanosine (8-OH-dGua), an indicator for oxidative DNA damage, in neo- and Bcl-2-overexpressing HL-60 cells after treating with 1,4-hydroquinone or 1,4-benzoquinone.	8-ohdg	40-63	BCL2 apoptosis regulator	Homo sapiens	128-133
10446756-5	1999	Active oxygen scavengers such as superoxide dismutase and catalase effectively blocked the formation of 8-OHdG in culture medium, and deferoxamine, which inhibits hydroxyl radicals production by chelating iron, was also effective in inhibiting the DEP-produced 8-OHdG formation.	8-ohdg	104-110	catalase	Mus musculus	58-66
10446756-5	1999	Active oxygen scavengers such as superoxide dismutase and catalase effectively blocked the formation of 8-OHdG in culture medium, and deferoxamine, which inhibits hydroxyl radicals production by chelating iron, was also effective in inhibiting the DEP-produced 8-OHdG formation.	8-ohdg	261-267	catalase	Mus musculus	58-66
10224318-13	1999	CYP1A2 activity was not affected by driving area but was correlated with the 8-oxodG excretion on the workday (r=0.53; p<0.05).	8-ohdg	77-84	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
9737965-10	1998	Incubation of 2"-deoxyguanosine with phenytoin and PHS-1 resulted in a 5-fold increase in its oxidation to 8-hydroxy-2"-deoxyguanosine.	8-ohdg	107-134	prostaglandin-endoperoxide synthase 1	Homo sapiens	51-56
10027302-10	1999	The content of 8-hydroxydeoxyguanosine (8-OHdG) by which the cellular DNA damage caused by active oxygen species can be assessed was significantly low in the tumours arising from the QR clone with high levels of Mn-SOD and GPchi even if the clone had been co-implanted with gelatin sponge, compared with the arising tumour from the QR clone with low levels of those antioxidative enzymes (P<0.001).	8-ohdg	15-38	superoxide dismutase 2, mitochondrial	Mus musculus	212-218
10027302-10	1999	The content of 8-hydroxydeoxyguanosine (8-OHdG) by which the cellular DNA damage caused by active oxygen species can be assessed was significantly low in the tumours arising from the QR clone with high levels of Mn-SOD and GPchi even if the clone had been co-implanted with gelatin sponge, compared with the arising tumour from the QR clone with low levels of those antioxidative enzymes (P<0.001).	8-ohdg	40-46	superoxide dismutase 2, mitochondrial	Mus musculus	212-218
10202397-5	1999	However, the levels of 8-hydroxydeoxyguanosine (8-OH-dG), a marker of oxidative DNA damage, were significantly suppressed in mice treated with green tea or EGCG.	8-ohdg	23-46	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	149-152
10202397-5	1999	However, the levels of 8-hydroxydeoxyguanosine (8-OH-dG), a marker of oxidative DNA damage, were significantly suppressed in mice treated with green tea or EGCG.	8-ohdg	48-55	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	149-152
10077490-6	1999	Increases in the number of 8-oxo-dG/10(5) dG were significant for each 2-HE2 and 4-HE2.	8-ohdg	27-35	sperm associated antigen 11A	Homo sapiens	73-76
10077490-6	1999	Increases in the number of 8-oxo-dG/10(5) dG were significant for each 2-HE2 and 4-HE2.	8-ohdg	27-35	sperm associated antigen 11A	Homo sapiens	83-86
10672257-5	1999	Immunohistochemical staining for markers of oxidative damage against 3-nitrotyrosine (3-NT) and 8-hydroxydeoxyguanosine (8-OHDG) were significantly more intense around the A beta 42 injection compared to the A beta 40 injection sites.	8-ohdg	96-119	amyloid beta (A4) precursor protein	Mus musculus	172-178
10672257-5	1999	Immunohistochemical staining for markers of oxidative damage against 3-nitrotyrosine (3-NT) and 8-hydroxydeoxyguanosine (8-OHDG) were significantly more intense around the A beta 42 injection compared to the A beta 40 injection sites.	8-ohdg	121-127	amyloid beta (A4) precursor protein	Mus musculus	172-178
9774481-4	1998	The reduction in MnSOD activity in Sod2(-/+) mice was correlated to an increase in oxidative damage to mitochondria: decreased activities of the Fe-S proteins (aconitase and NADH oxidoreductase), increased carbonyl groups in proteins, and increased levels of 8-hydroxydeoxyguanosine in mitochondrial DNA.	8-ohdg	259-282	superoxide dismutase 2, mitochondrial	Mus musculus	17-22
9774481-4	1998	The reduction in MnSOD activity in Sod2(-/+) mice was correlated to an increase in oxidative damage to mitochondria: decreased activities of the Fe-S proteins (aconitase and NADH oxidoreductase), increased carbonyl groups in proteins, and increased levels of 8-hydroxydeoxyguanosine in mitochondrial DNA.	8-ohdg	259-282	superoxide dismutase 2, mitochondrial	Mus musculus	35-39
9657375-2	1998	Expression levels of hMTH1 mRNA were inversely proportional to cellular levels of 8-oxo-deoxyguanosine.	8-ohdg	82-102	nudix hydrolase 1	Homo sapiens	21-26
9702526-7	1998	Previous work has shown that 8-oxodG favours the syn glycosidic conformation due to steric repulsion, whereas dG assumes the anti.	8-ohdg	29-36	synemin	Homo sapiens	49-52
9566706-5	1998	The elevated expression of 8-oxo-dGTPase in human breast ductal carcinoma cells appears to be a general characteristic of breast tumors and may provide the tumor cell with a cellular defense mechanism to prevent the incorporation of 8-hydroxy-deoxyguanosine during DNA replication.	8-ohdg	233-257	nudix hydrolase 1	Homo sapiens	27-40
9350336-9	1997	The contents of lipid peroxides and 8-OH-dG in the spermatozoa were increased from 24.6 +/- 2.4 nmol MDA/1 x 10(7) sperm and 0.17 +/- 0.02% in the untreated group to 30.6 +/- 1.2 nmol MDA/1 x 10(7) sperm and 1.9 +/- 0.47%, respectively, in the sperm treated at 37 degrees C for 1 hr with 2.03 mM H2O2, 1.8 mM ADP and 4.5 mM FeSO4.	8-ohdg	36-43	interleukin 19	Homo sapiens	101-106
9397153-6	1998	Our results clearly demonstrated that the level of 8 ohdG increased in L929 cells in a TNF alpha dose-dependent manner.	8-ohdg	51-57	tumor necrosis factor	Mus musculus	87-96
9397153-9	1998	We found that TNF alpha-induced 8 ohdG was decreased in cells overexpressing exogenous small HSP25.	8-ohdg	32-38	tumor necrosis factor	Mus musculus	14-23
9397153-9	1998	We found that TNF alpha-induced 8 ohdG was decreased in cells overexpressing exogenous small HSP25.	8-ohdg	32-38	heat shock protein 1	Mus musculus	93-98
9327726-9	1997	These findings suggest that CYP2A5 contributes to the superoxide production and 8-hydroxydeoxyguanosine formation, although reactive oxygen species from an unknown source in the hepatocytes leading to CYP2A5 induction or coincidental occurrence of these events are also possibilities.	8-ohdg	80-103	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	28-34
9525279-7	1998	In addition, injection of either anti-ICAM-1 adhesion molecule antibody alone (P < 0.004) or in combination with anti-beta2 integrin antibody (P < 0.001) significantly inhibited TPA-induced production of 7,8-dihydroxy-2"-deoxyguanosine (8-OHdG) immunoreactive proteins by epidermal keratinocytes.	8-ohdg	243-249	intercellular adhesion molecule 1	Mus musculus	38-44
9525279-7	1998	In addition, injection of either anti-ICAM-1 adhesion molecule antibody alone (P < 0.004) or in combination with anti-beta2 integrin antibody (P < 0.001) significantly inhibited TPA-induced production of 7,8-dihydroxy-2"-deoxyguanosine (8-OHdG) immunoreactive proteins by epidermal keratinocytes.	8-ohdg	243-249	hemoglobin, beta adult minor chain	Mus musculus	121-126
9397153-0	1998	Overexpression of HSP25 reduces the level of TNF alpha-induced oxidative DNA damage biomarker, 8-hydroxy-2"-deoxyguanosine, in L929 cells.	8-ohdg	95-122	heat shock protein 1	Mus musculus	18-23
9397153-0	1998	Overexpression of HSP25 reduces the level of TNF alpha-induced oxidative DNA damage biomarker, 8-hydroxy-2"-deoxyguanosine, in L929 cells.	8-ohdg	95-122	tumor necrosis factor	Mus musculus	45-54
9207108-8	1997	The mouse ogg1 gene product acts efficiently on DNA duplexes in which 7, 8-dihydroxy-8-oxo-2"-deoxyguanosine (8-oxodG) is paired with dC, acts weakly on duplexes in which 8-oxodG is paired with dT or dG, and is inactive against duplexes in which 8-oxodG is paired with dA.	8-ohdg	110-117	8-oxoguanine DNA-glycosylase 1	Mus musculus	10-14
9207108-8	1997	The mouse ogg1 gene product acts efficiently on DNA duplexes in which 7, 8-dihydroxy-8-oxo-2"-deoxyguanosine (8-oxodG) is paired with dC, acts weakly on duplexes in which 8-oxodG is paired with dT or dG, and is inactive against duplexes in which 8-oxodG is paired with dA.	8-ohdg	171-178	8-oxoguanine DNA-glycosylase 1	Mus musculus	10-14
9207108-8	1997	The mouse ogg1 gene product acts efficiently on DNA duplexes in which 7, 8-dihydroxy-8-oxo-2"-deoxyguanosine (8-oxodG) is paired with dC, acts weakly on duplexes in which 8-oxodG is paired with dT or dG, and is inactive against duplexes in which 8-oxodG is paired with dA.	8-ohdg	171-178	8-oxoguanine DNA-glycosylase 1	Mus musculus	10-14
9202163-3	1997	An increase in urinary 8-OHdG/creatinine was found in non-small-cell carcinoma (non-SCC) patients during the course of radiotherapy.	8-ohdg	23-29	serpin family B member 3	Homo sapiens	84-87
9177181-1	1997	Consistent with previous observations, proliferating cell nuclear antigen (PCNA) promotes DNA synthesis by calf thymus DNA polymerase delta (pol delta) past several chemically defined template lesions including model abasic sites, 8-oxo-deoxyguanosine (dG) and aminofluorene-dG (but not acetylaminofluorene-dG).	8-ohdg	231-251	proliferating cell nuclear antigen	Bos taurus	39-73
9177181-1	1997	Consistent with previous observations, proliferating cell nuclear antigen (PCNA) promotes DNA synthesis by calf thymus DNA polymerase delta (pol delta) past several chemically defined template lesions including model abasic sites, 8-oxo-deoxyguanosine (dG) and aminofluorene-dG (but not acetylaminofluorene-dG).	8-ohdg	231-251	proliferating cell nuclear antigen	Bos taurus	75-79
9202163-4	1997	SCC patients showed higher levels of urinary 8-OHdG/creatinine than the controls.	8-ohdg	45-51	serpin family B member 3	Homo sapiens	0-3
9202163-5	1997	Furthermore, SCC patients with complete or partial response to the chemotherapy showed a significant decrease in urinary 8-OHdG/creatinine while patients with no change or progressive disease showed an increase.	8-ohdg	121-127	serpin family B member 3	Homo sapiens	13-16
8951230-8	1996	We have therefore examined the abilities of PCB metabolites to induce free radical-mediated oxidative DNA damage using a newly developed, highly sensitive, 32P-postlabeling assay for 8-oxode-oxyguanosine (8-oxodG) [Devanaboyina, U., and Gupta, R. (1996) Carcinogenesis 17, 917-924].	8-ohdg	183-203	pyruvate carboxylase	Homo sapiens	44-47
9358240-5	1997	Catalase, at a concentration of 50 U/ml, reduced the yields of UVA- and UVB-induced 8-oxodGuo formation by approximately 50%, but had little effect on UVC-induced 8-oxodGuo production.	8-ohdg	84-93	catalase	Bos taurus	0-8
9118876-5	1996	Habitual alcohol intake appeared to increase 8-OHdG in PMN from ALDH2-deficient subjects.	8-ohdg	45-51	aldehyde dehydrogenase 2 family member	Homo sapiens	64-69
8951230-8	1996	We have therefore examined the abilities of PCB metabolites to induce free radical-mediated oxidative DNA damage using a newly developed, highly sensitive, 32P-postlabeling assay for 8-oxode-oxyguanosine (8-oxodG) [Devanaboyina, U., and Gupta, R. (1996) Carcinogenesis 17, 917-924].	8-ohdg	205-212	pyruvate carboxylase	Homo sapiens	44-47
8951230-10	1996	Substituting CuCl(2) (100 microM) for lactoperoxidase/H2O2, however, resulted in a substantial increase in 8-oxodG content (2669 8-oxodG/10(6) nucleotides).	8-ohdg	107-114	lactoperoxidase	Bos taurus	38-53
8951230-10	1996	Substituting CuCl(2) (100 microM) for lactoperoxidase/H2O2, however, resulted in a substantial increase in 8-oxodG content (2669 8-oxodG/10(6) nucleotides).	8-ohdg	129-136	lactoperoxidase	Bos taurus	38-53
8951230-12	1996	The addition of catalase (100 U/mL) and sodium azide (0.1 M) reduced the effect of CuCl(2) (849 and 896 8-oxodG/10(6) nucleotides, respectively), while superoxide dismutase (600 U/mL) moderately stimulated and glutathione (100 microM) substantially stimulated 8-oxodG formation (3014 and 4415 8-oxodG/10(6) nucleotides, respectively).	8-ohdg	104-111	catalase	Homo sapiens	16-24
8951230-12	1996	The addition of catalase (100 U/mL) and sodium azide (0.1 M) reduced the effect of CuCl(2) (849 and 896 8-oxodG/10(6) nucleotides, respectively), while superoxide dismutase (600 U/mL) moderately stimulated and glutathione (100 microM) substantially stimulated 8-oxodG formation (3014 and 4415 8-oxodG/10(6) nucleotides, respectively).	8-ohdg	260-267	catalase	Homo sapiens	16-24
8951230-12	1996	The addition of catalase (100 U/mL) and sodium azide (0.1 M) reduced the effect of CuCl(2) (849 and 896 8-oxodG/10(6) nucleotides, respectively), while superoxide dismutase (600 U/mL) moderately stimulated and glutathione (100 microM) substantially stimulated 8-oxodG formation (3014 and 4415 8-oxodG/10(6) nucleotides, respectively).	8-ohdg	260-267	catalase	Homo sapiens	16-24
8687011-2	1996	Extensive fragmentation of mtDNA was detected in association with increased 8-hydroxydeoxyguanosine content in the heart mitochondrial DNA (mtDNA) from a patient with premature aging and mitochondrial cardiomyopathy, who carried a mutation within the mitochondrial tRNA(Asp) gene.	8-ohdg	76-99	assembly factor for spindle microtubules	Homo sapiens	251-274
8761434-5	1996	The observation that K-ras mutations occurred only at G:C base pairs is in agreement with N7-guanine being the primary site of AFB1-DNA adduct formation and with guanine residues being targets for AFB1-induced oxidative DNA damage via formation of 8-hydroxydeoxyguanosine (8-OHdG).	8-ohdg	248-271	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	21-26
8761434-5	1996	The observation that K-ras mutations occurred only at G:C base pairs is in agreement with N7-guanine being the primary site of AFB1-DNA adduct formation and with guanine residues being targets for AFB1-induced oxidative DNA damage via formation of 8-hydroxydeoxyguanosine (8-OHdG).	8-ohdg	273-279	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	21-26
8836981-2	1996	The molar ratio of 8-OH-dG/deoxyguanosine in skeletal muscle from PEO or KSS patients was significantly higher than the control value.	8-ohdg	19-26	twinkle mtDNA helicase	Homo sapiens	66-69
8836981-5	1996	Our findings suggest that overproduction of 8-OH-dG and mitochondrial dysfunction with gene deletions are associated with each other in muscle cells of patients with PEO or KSS, and that free radicals may play an important role in the pathophysiology of mitochondrial encephalomyopathies.	8-ohdg	44-51	twinkle mtDNA helicase	Homo sapiens	166-169
8640938-1	1996	Oxidative damage from reactive oxygen species including free radicals has been considered to play a vital role in many degenerative diseases and measurement of 8-hydroxy-2"-deoxyguanosine (Oh8dG) in tissue DNA has been used as a benchmark for oxidative DNA damage.	8-ohdg	189-194	dacapo	Drosophila melanogaster	4-5
8640938-1	1996	Oxidative damage from reactive oxygen species including free radicals has been considered to play a vital role in many degenerative diseases and measurement of 8-hydroxy-2"-deoxyguanosine (Oh8dG) in tissue DNA has been used as a benchmark for oxidative DNA damage.	8-ohdg	189-194	dacapo	Drosophila melanogaster	11-12
8637871-1	1996	Induction of cytochrome P4501A1 (CYP1A1) in the hepatoma Hepa1c1c7 cell line results in an elevation in the excretion rate of 8-oxoguanine (oxo8Gua), a biomarker of oxidative DNA damage and the major repair product of 8-oxo-2"-deoxyguanosine (oxo8dG) residues in DNA.	8-ohdg	218-241	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-31
8637871-1	1996	Induction of cytochrome P4501A1 (CYP1A1) in the hepatoma Hepa1c1c7 cell line results in an elevation in the excretion rate of 8-oxoguanine (oxo8Gua), a biomarker of oxidative DNA damage and the major repair product of 8-oxo-2"-deoxyguanosine (oxo8dG) residues in DNA.	8-ohdg	218-241	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
8603471-8	1995	Together with our previous findings of DNA adducts and 8-hydroxydeoxyguanosine formation in the early stage of EE-induced carcinogenesis resulting in DNA damage, the present results suggest that estrogen enhanced ODC activity which was followed by increased DNA synthesis (DNA replication).	8-ohdg	55-78	ornithine decarboxylase 1	Rattus norvegicus	213-216
8834359-3	1996	Catalase and formate inhibited the 8-OHdG formation while superoxide dismutase enhanced it.	8-ohdg	35-41	catalase	Homo sapiens	0-8
8571399-4	1996	Catalase and formate inhibited the 8-OHdG formation while superoxide dismutase enhanced it.	8-ohdg	35-41	catalase	Homo sapiens	0-8
8568912-8	1996	HPLC measurements showed that .OH radicals and 1O2 generated by Co(II) reactions caused 2"-deoxyguanosine hydroxylation to form 8-hydroxy-2"-deoxyguanosine.	8-ohdg	128-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
7826371-3	1995	The content of 8-hydroxydeoxyguanosine in nuclear DNA increased during the early period of exposure to hydrogen peroxide, that is, it peaked at 1 h in the cells treated with 1 mM hydrogen peroxide and then declined, but not to the control levels within 4 h. Interestingly, immunofluorescence staining of treated cells revealed that cytoplasmic hsp70 protein translocated transiently into the nucleus, which was most remarkable around 30 min after the addition of 1 mM hydrogen peroxide into the culture medium.	8-ohdg	15-38	heat shock protein family A (Hsp70) member 4	Homo sapiens	344-349
7797567-3	1995	Overexpression of Cu,Zn-SOD and catalase caused a retardation in the accumulation of 8-hydroxydeoxyguanosine during aging and in response to the exposure of live flies to x-rays.	8-ohdg	85-108	Superoxide dismutase 1	Drosophila melanogaster	18-27
7797567-3	1995	Overexpression of Cu,Zn-SOD and catalase caused a retardation in the accumulation of 8-hydroxydeoxyguanosine during aging and in response to the exposure of live flies to x-rays.	8-ohdg	85-108	Catalase	Drosophila melanogaster	32-40
7646926-3	1995	By use of the electrochemical detector, a suitable retention time interval is set for collection of the fraction containing 8OHdG from the chromatography on the first column; this fraction is collected in a 2 mL loop and injected onto the C18 column.	8-ohdg	124-129	Bardet-Biedl syndrome 9	Homo sapiens	239-242
7998936-11	1994	Moreover, the glycation of Cu,Zn-SOD caused the substantial formation of 8-OH-dG in DNA.	8-ohdg	73-80	superoxide dismutase 1	Homo sapiens	27-36
7811268-1	1994	Calyculin A(CA) induced 8-hydroxydeoxyguanosine (8OHdG), typical of mutagenic oxidative DNA damage, in N-Formyl-Methionyl-Leucyl-Phenylalanine (FMLP)-stimulated dimethyl sulfoxide(DMSO)-differentiated HL60(DMSO-HL60), which has characteristics similar to those of human neutrophils.	8-ohdg	24-47	formyl peptide receptor 1	Homo sapiens	144-148
2114224-2	1990	Both the formation of hydrogen peroxide and that of 8-OHdG in DNA was significantly decreased when catalase or tyrosinase was added to the smoke condensates, and this also occurred when pure hydroquinone or catechol, two major constitutes in cigarette smoke, was used instead of smoke condensate.	8-ohdg	52-58	catalase	Homo sapiens	99-107
1383778-8	1992	In ss DNA 8-oxo-dG seemed to be a more prominent product than in the case of reaction of 1O2 with free dGp.	8-ohdg	10-18	dacapo	Drosophila melanogaster	32-33
1383778-12	1992	A preference for G(C) to T(A) transversions can be observed for which 8-oxo-dG might have been responsible.	8-ohdg	70-78	dacapo	Drosophila melanogaster	0-1
1383778-12	1992	A preference for G(C) to T(A) transversions can be observed for which 8-oxo-dG might have been responsible.	8-ohdg	70-78	Calbindin 53E	Drosophila melanogaster	19-20
1383778-12	1992	A preference for G(C) to T(A) transversions can be observed for which 8-oxo-dG might have been responsible.	8-ohdg	70-78	dacapo	Drosophila melanogaster	27-28
8012524-0	1994	8-Hydroxydeoxyguanosine in DNA from TPA-stimulated human granulocytes.	8-ohdg	0-23	plasminogen activator, tissue type	Homo sapiens	36-39
8012524-9	1994	We conclude that the amount of 8-OHdG produced in the DNA of TPA-stimulated human granulocytes is indistinguishable from that seen in control (unstimulated) cells (less than one 8-OHdG/10(5) dG).	8-ohdg	31-37	plasminogen activator, tissue type	Homo sapiens	61-64
8012524-9	1994	We conclude that the amount of 8-OHdG produced in the DNA of TPA-stimulated human granulocytes is indistinguishable from that seen in control (unstimulated) cells (less than one 8-OHdG/10(5) dG).	8-ohdg	178-184	plasminogen activator, tissue type	Homo sapiens	61-64
1315708-6	1992	The formation of 8-OH-dG in DNA by autooxidized methyl linolenate was dependent on the presence of the transition metal ions Cu or Fe and was inhibited by various scavengers, including superoxide dismutase and catalase.	8-ohdg	17-24	catalase	Bos taurus	210-218
2029751-4	1991	The antibodies, raised in rabbits following immunization with protein carrier-hapten conjugates prepared by covalently linking periodate-treated 8-hydroxyguanosine (oh8G) to bovine serum albumin (BSA) or casein, bind oh8dG with high affinity and selectivity, as measured by a competitive radioimmunoassay (RIA).	8-ohdg	217-222	albumin	Oryctolagus cuniculus	181-200
2114224-2	1990	Both the formation of hydrogen peroxide and that of 8-OHdG in DNA was significantly decreased when catalase or tyrosinase was added to the smoke condensates, and this also occurred when pure hydroquinone or catechol, two major constitutes in cigarette smoke, was used instead of smoke condensate.	8-ohdg	52-58	tyrosinase	Homo sapiens	111-121
33767351-6	2021	The numbers of cells stained for neutrophil elastase and F4/80-positive inflammatory cells were significantly decreased, with levels of interleukin(IL)-1beta, IL-6, tumor necrosis factor(TNF)-alpha, and total ROS/RNS amounts markedly reduced in the 8-oxo-dG, FML, and PDE groups (each p < 0.05).	8-ohdg	249-257	elastase, neutrophil expressed	Mus musculus	33-52
34939720-7	2022	Interestingly, 128.75 and 172.8 microM capsaicin treatment increased SIRT1 expression levels in HL-7702 cells, resulting in an increase in GSH levels and a decrease in TOS, CYC, CAPS3, and 8-OHdG levels through NOX4 inhibition.	8-ohdg	189-195	sirtuin 1	Homo sapiens	69-74
34799157-8	2022	Furthermore, a 1-unit increase in CRP was associated with decreases of - 0.765 to - 0.254 in MNF, - 0.400 to - 0.051 in urinary 8-OHdG.	8-ohdg	128-134	C-reactive protein	Homo sapiens	34-37
34799157-10	2022	11.58% of the relationship between concentration of blood Cr and urinary 8-OHdG was mediated by C1q.	8-ohdg	73-79	complement C1q A chain	Homo sapiens	96-99
34969250-10	2022	Moreover, for the same concentration of HN1/2/3 exposure groups, as the cytotoxicity increased according to the order of HN3 < HN1 < HN2, the contents of 8-oxo-dG, 5-m-dC, 5-hm-dC, and N6-Me-dA increased, whereas the content of O6-Me-dG decreased.	8-ohdg	154-162	MT-RNR2 like 2 (pseudogene)	Homo sapiens	133-136
34619205-7	2022	In addition, rs4656116 (1p22.3/CACL1), rs16958760 (17p11.2/between USP43 and DHRS7C) and rs11651078 (17p11.2/LOC339260) showed significant gene-TCS interactions with 8-OHdG (all P < 5 x 10-8).	8-ohdg	166-172	ubiquitin specific peptidase 43	Homo sapiens	67-72
34619205-7	2022	In addition, rs4656116 (1p22.3/CACL1), rs16958760 (17p11.2/between USP43 and DHRS7C) and rs11651078 (17p11.2/LOC339260) showed significant gene-TCS interactions with 8-OHdG (all P < 5 x 10-8).	8-ohdg	166-172	dehydrogenase/reductase 7C	Homo sapiens	77-83
34969250-10	2022	Moreover, for the same concentration of HN1/2/3 exposure groups, as the cytotoxicity increased according to the order of HN3 < HN1 < HN2, the contents of 8-oxo-dG, 5-m-dC, 5-hm-dC, and N6-Me-dA increased, whereas the content of O6-Me-dG decreased.	8-ohdg	154-162	Jupiter microtubule associated homolog 1	Homo sapiens	40-47
34969250-10	2022	Moreover, for the same concentration of HN1/2/3 exposure groups, as the cytotoxicity increased according to the order of HN3 < HN1 < HN2, the contents of 8-oxo-dG, 5-m-dC, 5-hm-dC, and N6-Me-dA increased, whereas the content of O6-Me-dG decreased.	8-ohdg	154-162	MT-RNR2 like 3 (pseudogene)	Homo sapiens	121-124
34969250-10	2022	Moreover, for the same concentration of HN1/2/3 exposure groups, as the cytotoxicity increased according to the order of HN3 < HN1 < HN2, the contents of 8-oxo-dG, 5-m-dC, 5-hm-dC, and N6-Me-dA increased, whereas the content of O6-Me-dG decreased.	8-ohdg	154-162	Jupiter microtubule associated homolog 1	Homo sapiens	127-130
34582115-8	2022	We observed higher levels of 8-OHdG in patients with MnSOD and XRCC1 mutant genotypes and higher XRCC1 levels in patients with NOX p22 fox mutant genotypes rather than controls.	8-ohdg	29-35	superoxide dismutase 2	Homo sapiens	53-58
34582115-8	2022	We observed higher levels of 8-OHdG in patients with MnSOD and XRCC1 mutant genotypes and higher XRCC1 levels in patients with NOX p22 fox mutant genotypes rather than controls.	8-ohdg	29-35	X-ray repair cross complementing 1	Homo sapiens	63-68
34939720-7	2022	Interestingly, 128.75 and 172.8 microM capsaicin treatment increased SIRT1 expression levels in HL-7702 cells, resulting in an increase in GSH levels and a decrease in TOS, CYC, CAPS3, and 8-OHdG levels through NOX4 inhibition.	8-ohdg	189-195	NADPH oxidase 4	Homo sapiens	211-215
34977005-6	2021	In addition, both serum MDA and 8-OHdG levels were significantly correlated with CXCL10 expression in patients with NSV.	8-ohdg	32-38	C-X-C motif chemokine ligand 10	Homo sapiens	81-87
34650811-8	2021	Cytoplasmic TERT expression was markedly associated with hepatitis B surface antigen, poor tumor differentiation, and expression levels of DNA-PKcs and 8-OHdG.	8-ohdg	152-158	telomerase reverse transcriptase	Homo sapiens	12-16
34975397-6	2021	The CARMIL3(+) neurons and neurites in the mismatch and T2(+) areas were larger than those in the control area, and associated with (1) increased expression of sulfonylurea receptor 1 (SUR1), indicating edema, (2) accumulation of p62, indicating impaired autophagy, and (3) increase in 8-hydroxy-2"-deoxyguanosine (8-OHdG), indicating oxidative stress.	8-ohdg	315-321	capping protein regulator and myosin 1 linker 3	Rattus norvegicus	4-11
34666282-7	2021	Flow cytometry and immunnofluorescence showed that ATF3 deficiency inhibited H2O2-induced ROS production and the expression of 8 OHdG and 4-HNE.	8-ohdg	127-133	activating transcription factor 3	Homo sapiens	51-55
34975397-6	2021	The CARMIL3(+) neurons and neurites in the mismatch and T2(+) areas were larger than those in the control area, and associated with (1) increased expression of sulfonylurea receptor 1 (SUR1), indicating edema, (2) accumulation of p62, indicating impaired autophagy, and (3) increase in 8-hydroxy-2"-deoxyguanosine (8-OHdG), indicating oxidative stress.	8-ohdg	286-313	capping protein regulator and myosin 1 linker 3	Rattus norvegicus	4-11
34769136-10	2021	Moreover, CRIF1-KO sham mice had increased 8-OHDG-positive cell recruitment compared with WT-sham mice.	8-ohdg	43-49	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	10-15
34754366-10	2021	QR increased the reduction of the brain-derived neurotrophic factor that was elicited by RB-Ed and acts as an anti-inflammatory agent by reducing the proinflammatory marker, interleukin 1 beta and DNA damage markers, heat shock protein 70, and 8-hydroxydeoxyguanosine.	8-ohdg	244-267	brain-derived neurotrophic factor	Rattus norvegicus	34-67
34769136-11	2021	CRIF1-KO-UUO kidneys had increased recruitment of 8-OHDG-positive cells compared with WT-UUO kidneys.	8-ohdg	50-56	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	0-5
34769136-9	2021	In sham mice, urinary 8-hydroxydeoxyguanosine (8-OHDG) was higher in CRIF1-KO mice than in WT mice.	8-ohdg	22-45	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	69-74
34439496-6	2021	Old miR-29a transgenic mice showed fewer osteoporosis signs, less 5mC, and less 8-OHdG formation than age-matched wild-type mice.	8-ohdg	80-86	microRNA 29a	Mus musculus	4-11
34769136-9	2021	In sham mice, urinary 8-hydroxydeoxyguanosine (8-OHDG) was higher in CRIF1-KO mice than in WT mice.	8-ohdg	47-53	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	69-74
34480417-6	2021	More importantly, TH588-mediated MTH1 inhibition could destroy the ROS-defensing system of tumor cells by preventing the elimination of 8-oxo-2"-deoxyguanosine triphosphate (8-oxo-dG), thereby exacerbating the oxidative DNA damage induced by the photodynamic therapy (PDT) of Ce6 under light irradiation.	8-ohdg	174-182	nudix hydrolase 1	Homo sapiens	33-37
34485154-8	2021	5-FU promoted the expression of Keap1 and increased the binding to NF-E2-related factor 2 (Nrf2) to reduce the nuclear translocation of Nrf2, thereby weakening the transcriptional activity of Nrf2 to inhibit the expression of HO-1; reducing the activity of GSH, SOD, and CAT to increase ROS content; and aggravating DNA damage (indicated by the increase in 8-OHdG).	8-ohdg	357-363	NFE2 like bZIP transcription factor 2	Homo sapiens	67-89
34485154-8	2021	5-FU promoted the expression of Keap1 and increased the binding to NF-E2-related factor 2 (Nrf2) to reduce the nuclear translocation of Nrf2, thereby weakening the transcriptional activity of Nrf2 to inhibit the expression of HO-1; reducing the activity of GSH, SOD, and CAT to increase ROS content; and aggravating DNA damage (indicated by the increase in 8-OHdG).	8-ohdg	357-363	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
34535612-7	2021	Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164-222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199-1.52, p = 0.013) but not in women with EGWG.	8-ohdg	90-97	adiponectin, C1Q and collagen domain containing	Homo sapiens	74-85
34248629-7	2021	More importantly, in a nonhuman primate model of spontaneous stage III DKD, TBN increased the estimated glomerular filtration rate, decreased serum 3-nitrotyrosine, malonaldehyde and 8-hydroxy-2"-deoxyguanosine levels, and improved metabolic abnormalities.	8-ohdg	183-210	TATA-box binding protein associated factor 8	Rattus norvegicus	76-79
35472412-4	2022	The PPAR-gamma activation normalizes testicular lipid peroxidation, but its inhibition reduces lipid peroxidation and oxidative DNA damage (8-oxo-dG) in diabetic mice.	8-ohdg	140-148	peroxisome proliferator activated receptor gamma	Mus musculus	4-14
35427698-7	2022	Downregulating of midkine inhibited the increases of oxidative stress markers 8-OHdG, superoxide anions and MDA in the heart of mice or in the Ang II-treated HL-1 cells.	8-ohdg	78-84	midkine	Mus musculus	18-25
35512617-7	2022	Activation of NRF2 by sulforaphane significantly upregulated NRF2 levels in the BRCA1-depleted cells, and restored proliferation, apoptosis and 8-OXo-2"-deoxyguanosine level in a dose-dependent manner.	8-ohdg	144-167	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
35512617-6	2022	RESULTS: BRCA1 knockdown downregulated NRF2 and its target genes, increased proliferation rates, reduced apoptosis, and increased 8-OXo-2"-deoxyguanosine levels compared to the control.	8-ohdg	130-153	BRCA1 DNA repair associated	Homo sapiens	9-14
35527257-14	2022	The 8-oxodG formation was inhibited by catalase, methional and bathocuproine, suggesting that Cu(I)-hydroperoxide, which was generated via Cu(I) and H2O2, caused oxidative DNA base damage.	8-ohdg	4-11	catalase	Homo sapiens	39-47
35625933-10	2022	UVC/SK2 also caused DNA damage by detecting gammaH2AX and 8-hydroxy-2"-deoxyguanosine in oral cancer cells.	8-ohdg	58-85	sphingosine kinase 2	Homo sapiens	4-7
35303529-12	2022	Maternal 8-OHdG demonstrated 38.5-65.5% mediating effects in the negative association of IMI, ACE, 2-CTCA with head circumference.	8-ohdg	9-15	angiotensin I converting enzyme	Homo sapiens	94-97
35565198-10	2022	We suggest that 8-oxo-dG accumulates following increased oxidative stress due to hepatic tissue iron deposition; this may activate Wnt/beta-catenin signaling and trigger carcinogenesis.	8-ohdg	16-24	catenin beta 1	Homo sapiens	135-147
35398885-5	2022	We used the modified comet assay with the repair enzymes hOGG1 and T4endonucleaseV to detect the DNA damage associated with 8-oxo-7,8-dihydro-2"-deoxyguanosine and cyclobutane pyrimidine dimers lesions, respectively.	8-ohdg	124-159	8-oxoguanine DNA glycosylase	Homo sapiens	57-62
35234932-0	2022	8-oxodG accumulation within super-enhancers marks fragile CTCF-mediated chromatin loops.	8-ohdg	0-7	CCCTC-binding factor	Homo sapiens	58-62
35378954-8	2022	Oxidative modifications of lipids (4-hydroxynonenal) and nucleic acids (8-hydroxy-2"-deoxyguanosine (8-OHdG)) also increase with age.	8-ohdg	72-99	renin binding protein	Homo sapiens	129-132
35409327-4	2022	Colocalization of the oxidative stress marker 8-OHdG (8-hydroxyguanosine; 8-OHdG), with TH in the LC was performed.	8-ohdg	46-52	tyrosine hydroxylase	Rattus norvegicus	88-90
35409327-7	2022	The expression of 8-OHdG was increased in the LC neurons, with higher co-localization in TH-immunoreactive neurons.	8-ohdg	18-24	tyrosine hydroxylase	Rattus norvegicus	89-91
34988794-8	2022	Besides, PM2.5 significantly elevated OGG1 expression and suppressed MTH1 expression, which was correlated to oxidative stress and partially mediated by reducing OGG1 DNA methylation status and increasing miRNAs expression related to MTH1 in DNA damage with increases of gamma-H2AX, 8-OHdG and GADD153.	8-ohdg	283-289	8-oxoguanine DNA glycosylase	Rattus norvegicus	38-42
34988794-8	2022	Besides, PM2.5 significantly elevated OGG1 expression and suppressed MTH1 expression, which was correlated to oxidative stress and partially mediated by reducing OGG1 DNA methylation status and increasing miRNAs expression related to MTH1 in DNA damage with increases of gamma-H2AX, 8-OHdG and GADD153.	8-ohdg	283-289	nudix hydrolase 1	Rattus norvegicus	69-73
34988794-8	2022	Besides, PM2.5 significantly elevated OGG1 expression and suppressed MTH1 expression, which was correlated to oxidative stress and partially mediated by reducing OGG1 DNA methylation status and increasing miRNAs expression related to MTH1 in DNA damage with increases of gamma-H2AX, 8-OHdG and GADD153.	8-ohdg	283-289	nudix hydrolase 1	Rattus norvegicus	234-238
35378954-8	2022	Oxidative modifications of lipids (4-hydroxynonenal) and nucleic acids (8-hydroxy-2"-deoxyguanosine (8-OHdG)) also increase with age.	8-ohdg	101-107	renin binding protein	Homo sapiens	129-132
35273682-0	2022	A novel signal enhancement strategy for the detection of DNA oxidative damage biomarker 8-OHdG based on the synergy between beta-CD-CuNCs and multi-walled carbon nanotubes.	8-ohdg	88-94	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	124-131
35235741-0	2022	The influence of cdG on 8-oxodG excision by OGG1 and FPG glycosylases.	8-ohdg	24-31	8-oxoguanine DNA glycosylase	Homo sapiens	44-48
35121264-1	2022	OBJECTIVE: To evaluate the oxidative DNA damage, through 8-hydroxy-2"-deoxyguanosine (8-OHdG), and its repair by base excision repair pathway (Redox factor-1 (Ref-1); X-ray Repair Cross Complementing-1 (XRCC-1)) in different epithelial dysplasia degrees in oral leukoplakia.	8-ohdg	57-84	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	143-157
35121264-1	2022	OBJECTIVE: To evaluate the oxidative DNA damage, through 8-hydroxy-2"-deoxyguanosine (8-OHdG), and its repair by base excision repair pathway (Redox factor-1 (Ref-1); X-ray Repair Cross Complementing-1 (XRCC-1)) in different epithelial dysplasia degrees in oral leukoplakia.	8-ohdg	57-84	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	159-164
35121264-1	2022	OBJECTIVE: To evaluate the oxidative DNA damage, through 8-hydroxy-2"-deoxyguanosine (8-OHdG), and its repair by base excision repair pathway (Redox factor-1 (Ref-1); X-ray Repair Cross Complementing-1 (XRCC-1)) in different epithelial dysplasia degrees in oral leukoplakia.	8-ohdg	57-84	X-ray repair cross complementing 1	Homo sapiens	167-201
35121264-1	2022	OBJECTIVE: To evaluate the oxidative DNA damage, through 8-hydroxy-2"-deoxyguanosine (8-OHdG), and its repair by base excision repair pathway (Redox factor-1 (Ref-1); X-ray Repair Cross Complementing-1 (XRCC-1)) in different epithelial dysplasia degrees in oral leukoplakia.	8-ohdg	57-84	X-ray repair cross complementing 1	Homo sapiens	203-209
35121264-1	2022	OBJECTIVE: To evaluate the oxidative DNA damage, through 8-hydroxy-2"-deoxyguanosine (8-OHdG), and its repair by base excision repair pathway (Redox factor-1 (Ref-1); X-ray Repair Cross Complementing-1 (XRCC-1)) in different epithelial dysplasia degrees in oral leukoplakia.	8-ohdg	86-92	X-ray repair cross complementing 1	Homo sapiens	167-201
35121264-1	2022	OBJECTIVE: To evaluate the oxidative DNA damage, through 8-hydroxy-2"-deoxyguanosine (8-OHdG), and its repair by base excision repair pathway (Redox factor-1 (Ref-1); X-ray Repair Cross Complementing-1 (XRCC-1)) in different epithelial dysplasia degrees in oral leukoplakia.	8-ohdg	86-92	X-ray repair cross complementing 1	Homo sapiens	203-209
35268676-10	2022	Furthermore, SK2 caused DNA damage (gammaH2AX and 8-hydroxy-2"-deoxyguanosine).	8-ohdg	50-77	sphingosine kinase 2	Homo sapiens	13-16
35273682-1	2022	OBJECTIVE: To propose a novel signal enhancement strategy based on the synergy between beta-CD-CuNCs and multi-walled carbon nanotubes (MWCNTs) for the detection of DNA oxidative damage biomarker 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	196-223	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	87-94
35273682-1	2022	OBJECTIVE: To propose a novel signal enhancement strategy based on the synergy between beta-CD-CuNCs and multi-walled carbon nanotubes (MWCNTs) for the detection of DNA oxidative damage biomarker 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	225-231	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	87-94
35273682-2	2022	METHODS: The sensor was constructed with the beta-CD-CuNCs-MWCNTs-nafion film and successfully used for the quantitative detection of 8-OhdG in the presence of biomolecules such as ascorbic acid (AA) and uric acid (UA).	8-ohdg	134-140	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	45-52
33965877-5	2021	In addition, and independently of the first mechanism, 8-oxodG initiated a decline of the gene expression, which was mediated by the specific DNA glycosylase OGG1.	8-ohdg	55-62	8-oxoguanine DNA glycosylase	Homo sapiens	158-162
3729941-4	1986	Superoxide dismutase and catalase caused a marked decrease in the levels of 8-OHdG in the cellular DNA.	8-ohdg	76-82	catalase	Homo sapiens	25-33
33965877-6	2021	For the different 8-oxodG positions, the magnitude of this effect reflected the excision preferences of OGG1.	8-ohdg	18-25	8-oxoguanine DNA glycosylase	Homo sapiens	104-108
33852931-9	2021	Suppression of sestrin2 expression by siRNA enhanced Abeta25-35- and Abeta1-42-induced production of reactive oxygen species (ROS), lipid peroxidation, and formation of 8-hydroxy-2-deoxyguanosine (8-OH-dG).	8-ohdg	169-195	sestrin 2	Rattus norvegicus	15-23
33852931-9	2021	Suppression of sestrin2 expression by siRNA enhanced Abeta25-35- and Abeta1-42-induced production of reactive oxygen species (ROS), lipid peroxidation, and formation of 8-hydroxy-2-deoxyguanosine (8-OH-dG).	8-ohdg	197-204	sestrin 2	Rattus norvegicus	15-23
33758207-2	2021	MTH1 hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby avoiding 8-oxo-dG incorporation into DNA.	8-ohdg	16-24	nudix (nucleoside diphosphate linked moiety X)-type motif 1	Mus musculus	0-4
33621788-5	2021	Each SOD2 T allele was associated with an odds ratio of being mutation-positive of 1.69 (95%CI: 1.12-2.55, p = 0.013) through 8-oxodG.	8-ohdg	126-133	superoxide dismutase 2	Homo sapiens	5-9
33907247-5	2021	Oxidative stress, represented by urinary 8-hydroxy-2"-deoxyguanosine (8-OHdG), were higher in the octn1 knockout mice.	8-ohdg	41-68	solute carrier family 22 (organic cation transporter), member 4	Mus musculus	98-103
33907247-5	2021	Oxidative stress, represented by urinary 8-hydroxy-2"-deoxyguanosine (8-OHdG), were higher in the octn1 knockout mice.	8-ohdg	70-76	solute carrier family 22 (organic cation transporter), member 4	Mus musculus	98-103
33870811-6	2021	In brain tissue, while AChE enzyme activity was decreased depending on concentration, caspase-3 activity increased with 8-OHdG level.	8-ohdg	120-126	caspase-3b	Oncorhynchus mykiss	86-95
33897435-7	2021	The mechanical allodynia and thermal hyperalgesia in SNI rats were ameliorated by intrathecal injection of Nrf2 agonist tBHQ, which normalized expression of Nrf2 and NQO1 and reversed SNI-induced decrease in antioxidant enzyme superoxide dismutase (SOD) and increase in oxidative stress marker 8-hydroxy-2"-deoxyguanosine (8-OHdG) in the spinal cord.	8-ohdg	294-321	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
33897435-7	2021	The mechanical allodynia and thermal hyperalgesia in SNI rats were ameliorated by intrathecal injection of Nrf2 agonist tBHQ, which normalized expression of Nrf2 and NQO1 and reversed SNI-induced decrease in antioxidant enzyme superoxide dismutase (SOD) and increase in oxidative stress marker 8-hydroxy-2"-deoxyguanosine (8-OHdG) in the spinal cord.	8-ohdg	323-329	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
33450725-4	2021	MTH1 inhibition has variously been shown to induce genomic 8-oxo-dG elevation, genotoxic strand breaks in p53-functional cells, and tumor-inhibitory outcomes.	8-ohdg	59-67	nudix hydrolase 1	Homo sapiens	0-4
33450725-5	2021	Genomically incorporated 8-oxo-dG is excised by the base excision repair enzyme, 8-oxo-dG glycosylase 1 (OGG1).	8-ohdg	25-33	8-oxoguanine DNA glycosylase	Homo sapiens	81-103
33450725-5	2021	Genomically incorporated 8-oxo-dG is excised by the base excision repair enzyme, 8-oxo-dG glycosylase 1 (OGG1).	8-ohdg	25-33	8-oxoguanine DNA glycosylase	Homo sapiens	105-109
33836581-2	2021	There is also evidence suggesting that inhibition of the BER enzyme 8-oxoguanine DNA glycosylase-1 (OGG1), which initiates repair of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy-dG), could be useful in treating certain cancers.	8-ohdg	133-168	8-oxoguanine DNA glycosylase	Homo sapiens	100-104
33836581-2	2021	There is also evidence suggesting that inhibition of the BER enzyme 8-oxoguanine DNA glycosylase-1 (OGG1), which initiates repair of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy-dG), could be useful in treating certain cancers.	8-ohdg	170-178	8-oxoguanine DNA glycosylase	Homo sapiens	100-104
33836581-7	2021	The mechanism for this preferential toxicity was addressed using in vitro replication assays in which DNA polymerase delta was shown to insert Ara-C opposite 8-oxo-dG, resulting in termination of DNA synthesis.	8-ohdg	158-166	DNA polymerase delta 1, catalytic subunit	Homo sapiens	102-122
33522955-14	2021	In human HCC tissues, FOXC1 expression was positively correlated with oxidative damage marker 8-hydroxy-2"-deoxyguanosine (8-OHdG), p-ELK1 and DNMT3B expression, but negatively correlated with CTH expression.	8-ohdg	94-121	forkhead box C1	Homo sapiens	22-27
33251678-7	2021	RAD21 overexpression reduced culture medium 8-OHdG concentration and decreased the protein levels of gammaH2AX and ATM, suggesting that RAD21 overexpression attenuated IR treatment-induced DNA damage to HCC cells.	8-ohdg	44-50	RAD21 cohesin complex component	Homo sapiens	0-5
33522955-14	2021	In human HCC tissues, FOXC1 expression was positively correlated with oxidative damage marker 8-hydroxy-2"-deoxyguanosine (8-OHdG), p-ELK1 and DNMT3B expression, but negatively correlated with CTH expression.	8-ohdg	123-129	forkhead box C1	Homo sapiens	22-27
33060043-8	2021	Noticeably, only the 8-OHdG decrease correlated with steatosis amelioration and with the increase of IL-10 levels.	8-ohdg	21-27	interleukin 10	Homo sapiens	101-106
33373677-9	2021	Overexpressed PGC-1alpha results in a remarkable increase in the levels of VDR associated with a significant reduction in the expression of Abeta plaques and of 8-oxo-dG in 2xTg-AD mice.	8-ohdg	161-169	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	14-24
33373677-9	2021	Overexpressed PGC-1alpha results in a remarkable increase in the levels of VDR associated with a significant reduction in the expression of Abeta plaques and of 8-oxo-dG in 2xTg-AD mice.	8-ohdg	161-169	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	75-78
33290564-1	2021	8-Oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway.	8-ohdg	0-35	8-oxoguanine DNA glycosylase	Homo sapiens	110-115
33290564-1	2021	8-Oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway.	8-ohdg	0-35	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	120-124
33290564-1	2021	8-Oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway.	8-ohdg	37-46	8-oxoguanine DNA glycosylase	Homo sapiens	110-115
33290564-1	2021	8-Oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway.	8-ohdg	37-46	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	120-124
33290564-2	2021	In this work, we studied coordinated BER of 8-oxodGuo by hOGG1 and APE1 in nucleosome core particles and found that histones transiently formed DNA-protein cross-links (DPCs) with active repair intermediates such as 3"-phospho-alpha,beta-unsaturated aldehyde (PUA) and 5"-deoxyribosephosphate (dRP).	8-ohdg	44-53	8-oxoguanine DNA glycosylase	Homo sapiens	57-62
33290564-2	2021	In this work, we studied coordinated BER of 8-oxodGuo by hOGG1 and APE1 in nucleosome core particles and found that histones transiently formed DNA-protein cross-links (DPCs) with active repair intermediates such as 3"-phospho-alpha,beta-unsaturated aldehyde (PUA) and 5"-deoxyribosephosphate (dRP).	8-ohdg	44-53	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	67-71
33129239-1	2021	Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2"-deoxyguanosine (8-OHdG) mutagenicity.	8-ohdg	193-220	8-oxoguanine DNA glycosylase	Homo sapiens	47-77
33129239-1	2021	Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2"-deoxyguanosine (8-OHdG) mutagenicity.	8-ohdg	193-220	8-oxoguanine DNA glycosylase	Homo sapiens	79-83
33129239-1	2021	Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2"-deoxyguanosine (8-OHdG) mutagenicity.	8-ohdg	222-228	8-oxoguanine DNA glycosylase	Homo sapiens	47-77
33129239-1	2021	Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2"-deoxyguanosine (8-OHdG) mutagenicity.	8-ohdg	222-228	8-oxoguanine DNA glycosylase	Homo sapiens	79-83
33129239-7	2021	DNA damage, as measured by 8-OHdG and tail moment content, was found to be significantly higher in OGG1 homozygous mutants (mt/mt; 18.81 +- 3.34; 6.04 +- 0.52) as compared to wild-type genotypes (wt/wt; 10.34 +- 2.25; 5.19 +- 2.50) and heterozygous (wt/mt) mutants (12.82 +- 2.81; 6.04 +- 0.93) in the exposed group.	8-ohdg	27-33	8-oxoguanine DNA glycosylase	Homo sapiens	99-103
32914844-4	2020	However, the ligation efficiency of the LIG1 variants for DNA polymerase-promoted mutagenesis products with 3"-DNA mismatches or 8-oxo-2"-deoxyguanosine (8-oxodG) remains undefined.	8-ohdg	129-152	DNA ligase 1	Homo sapiens	40-44
32914844-4	2020	However, the ligation efficiency of the LIG1 variants for DNA polymerase-promoted mutagenesis products with 3"-DNA mismatches or 8-oxo-2"-deoxyguanosine (8-oxodG) remains undefined.	8-ohdg	154-161	DNA ligase 1	Homo sapiens	40-44
33055205-8	2020	Higher 8-oxo-dG correlated with markers of AD-related neurodegeneration including lower CSF Abeta-42 (r = -0.34; p = 0.012) and higher CSF NFL (r = 0.39; p = 0.0091) and total tau (r = 0.6696; p < 0.0001).	8-ohdg	7-15	neurofilament light chain	Homo sapiens	139-142
33055205-8	2020	Higher 8-oxo-dG correlated with markers of AD-related neurodegeneration including lower CSF Abeta-42 (r = -0.34; p = 0.012) and higher CSF NFL (r = 0.39; p = 0.0091) and total tau (r = 0.6696; p < 0.0001).	8-ohdg	7-15	microtubule associated protein tau	Homo sapiens	176-179
33372419-1	2021	BACKGROUND: The human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene encodes a DNA glycosylase that removes 8-hydroxy-2-deoxyguanine (8-OH-dG) DNA damage to protect against gene mutations.	8-ohdg	131-138	8-oxoguanine DNA glycosylase	Homo sapiens	54-59
33372419-2	2021	The association of hOGG1 Ser326Cys polymorphism with lung cancer risk has predicted that hOGG1-Cys variants are less effective at removing 8-OH-dG damage from DNA; therefore, these variants might show an increased occurrence of tumor suppressor gene and oncogene mutations.	8-ohdg	139-146	8-oxoguanine DNA glycosylase	Homo sapiens	19-24
33372419-2	2021	The association of hOGG1 Ser326Cys polymorphism with lung cancer risk has predicted that hOGG1-Cys variants are less effective at removing 8-OH-dG damage from DNA; therefore, these variants might show an increased occurrence of tumor suppressor gene and oncogene mutations.	8-ohdg	139-146	8-oxoguanine DNA glycosylase	Homo sapiens	89-94
32920340-4	2020	Under optimal conditions, 8-OHdG, 8-oxoG and IS were separated very well and exhibited a good linearity in the range of 0.5-50 ng mL-1, with correlation coefficients of R2 > 0.996.	8-ohdg	26-32	L1 cell adhesion molecule	Mus musculus	130-134
32330605-7	2020	RESULTS: In culture, TGF-beta1-pretreated human hepatic stellate cells (HHSteCs) exhibited lowered CYGB levels together with increased NADPH oxidase 4 (NOX4) expression and were primed for H2O2-triggered OH production and 8-OHdG generation.	8-ohdg	222-228	transforming growth factor beta 1	Homo sapiens	21-30
33048602-5	2020	Moreover, levels of klotho were negatively correlated with levels of 8-OHdG and IL-6, but positively correlated with levels of TSA and IL-10.	8-ohdg	69-75	klotho	Homo sapiens	20-26
32659346-8	2020	Lipid peroxides and 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels were much lower in organs from mice with depleted Casp3 than in those of wild type animals.	8-ohdg	20-47	caspase 3	Mus musculus	114-119
32659346-8	2020	Lipid peroxides and 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels were much lower in organs from mice with depleted Casp3 than in those of wild type animals.	8-ohdg	49-55	caspase 3	Mus musculus	114-119
32535241-8	2020	The study also highlights interaction between diabetes, oxidative stress and inflammation by examining the increased pro-inflammatory cytokines e.g. TNF-alpha and C-reactive protein (CRP) promotes DNA damage e.g. oxidation of 8-hydroxy-2-deoxyguanosine (8-OHdG) in chronic hyperglycaemia.	8-ohdg	226-252	tumor necrosis factor	Rattus norvegicus	149-158
32535241-8	2020	The study also highlights interaction between diabetes, oxidative stress and inflammation by examining the increased pro-inflammatory cytokines e.g. TNF-alpha and C-reactive protein (CRP) promotes DNA damage e.g. oxidation of 8-hydroxy-2-deoxyguanosine (8-OHdG) in chronic hyperglycaemia.	8-ohdg	226-252	C-reactive protein	Rattus norvegicus	163-181
32535241-8	2020	The study also highlights interaction between diabetes, oxidative stress and inflammation by examining the increased pro-inflammatory cytokines e.g. TNF-alpha and C-reactive protein (CRP) promotes DNA damage e.g. oxidation of 8-hydroxy-2-deoxyguanosine (8-OHdG) in chronic hyperglycaemia.	8-ohdg	226-252	C-reactive protein	Rattus norvegicus	183-186
32535241-8	2020	The study also highlights interaction between diabetes, oxidative stress and inflammation by examining the increased pro-inflammatory cytokines e.g. TNF-alpha and C-reactive protein (CRP) promotes DNA damage e.g. oxidation of 8-hydroxy-2-deoxyguanosine (8-OHdG) in chronic hyperglycaemia.	8-ohdg	254-260	tumor necrosis factor	Rattus norvegicus	149-158
32535241-8	2020	The study also highlights interaction between diabetes, oxidative stress and inflammation by examining the increased pro-inflammatory cytokines e.g. TNF-alpha and C-reactive protein (CRP) promotes DNA damage e.g. oxidation of 8-hydroxy-2-deoxyguanosine (8-OHdG) in chronic hyperglycaemia.	8-ohdg	254-260	C-reactive protein	Rattus norvegicus	163-181
32535241-8	2020	The study also highlights interaction between diabetes, oxidative stress and inflammation by examining the increased pro-inflammatory cytokines e.g. TNF-alpha and C-reactive protein (CRP) promotes DNA damage e.g. oxidation of 8-hydroxy-2-deoxyguanosine (8-OHdG) in chronic hyperglycaemia.	8-ohdg	254-260	C-reactive protein	Rattus norvegicus	183-186
33841550-4	2020	LCB alone and in combination with FnC60 significantly decreased DNA fragmentation, oxidative DNA damage (8-hydroxy-2"-deoxyguanosine levels), APE1/Ref-1, CDK-4, retinoblastoma, B- cell lymphoma-2 (Bcl-2), B-cell lymphoma-xL (Bcl-xL), and beta-arrestin-2 mRNA expression, and APE1/Ref-1 and CDK-4 protein expression.	8-ohdg	105-132	clathrin, light chain B	Rattus norvegicus	0-3
32330605-13	2020	Consistent with those observations in cultured HHSteCs, CYGB expression was negligible, but 8-OHdG was abundant, in activated alphaSMA+pSMAD2+- and alphaSMA+NOX4+-positive hepatic stellate cells from human NASH patients with advanced fibrosis.	8-ohdg	92-98	actin alpha 1, skeletal muscle	Homo sapiens	126-134
33072095-3	2020	To gain insight into this biology, we interrogated the role of oxyguanine glycosylase 1 (OGG1), which repairs oxidized guanine 8-Oxo-2"-deoxyguanosine (8-OH-dG), in the pristane-induced mouse model of SLE.	8-ohdg	152-159	8-oxoguanine DNA-glycosylase 1	Mus musculus	63-87
33072095-3	2020	To gain insight into this biology, we interrogated the role of oxyguanine glycosylase 1 (OGG1), which repairs oxidized guanine 8-Oxo-2"-deoxyguanosine (8-OH-dG), in the pristane-induced mouse model of SLE.	8-ohdg	152-159	8-oxoguanine DNA-glycosylase 1	Mus musculus	89-93
33015093-13	2020	Moreover, the stress marker 8-oxo-dG was independently associated with NAFLD after adjustment for mtDNAcn, IL-6, glucose tolerance status, and other conventional NAFLD risk factors (OR = 1.707, 95% CI =1.142-2.550, P = 0.009).	8-ohdg	28-36	interleukin 6	Homo sapiens	107-111
32942546-4	2020	Results indicated a significant 130% excess of 8-oxodG at -TGC- position of p53 codon 176 in HCV-HCC cases as compared to controls, after correction for age and gender, whereas a not significant increment of 5-OHC at -TGC- position was found.	8-ohdg	47-54	tumor protein p53	Homo sapiens	76-79
32924615-4	2020	According to the results obtained, the marker of DNA damage in tissues of 8-OHdG was determined to be significantly reduced in brain tissue of the OR1 and OR2 groups compared to the NC group.	8-ohdg	74-80	olfactory receptor 1750	Rattus norvegicus	147-150
32924615-4	2020	According to the results obtained, the marker of DNA damage in tissues of 8-OHdG was determined to be significantly reduced in brain tissue of the OR1 and OR2 groups compared to the NC group.	8-ohdg	74-80	olfactory receptor 1749	Rattus norvegicus	155-158
33533416-7	2020	In women with TIF, we also found significantly lower values of all tested markers in the FF, except for 8-OHdG and AMH.	8-ohdg	104-110	TYRO3 protein tyrosine kinase	Homo sapiens	14-17
32361133-8	2020	The correlation between DHBMA, CIMT, and 8-OHdG was more evident when the levels of CD31+/CD42a - or CD62 P were above 50%.	8-ohdg	41-47	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-88
32361133-8	2020	The correlation between DHBMA, CIMT, and 8-OHdG was more evident when the levels of CD31+/CD42a - or CD62 P were above 50%.	8-ohdg	41-47	glycoprotein IX platelet	Homo sapiens	90-95
32361133-8	2020	The correlation between DHBMA, CIMT, and 8-OHdG was more evident when the levels of CD31+/CD42a - or CD62 P were above 50%.	8-ohdg	41-47	selectin P	Homo sapiens	101-107
32374188-8	2020	Compared with the CD diet, the CRHP diet increased 24-hour urinary excretion of 8-oxoGuo by 9.3% (38.6 +- 12.6 vs. 35.3 +- 11.0 nmol/24 h, p = .03), whereas 8-oxodG did not differ between diets (24.0 +- 9.5 vs. 24.8 +- 11.1 nmol/24 h, p = .17).	8-ohdg	157-164	cysteine rich protein 1	Homo sapiens	31-35
32882839-6	2020	Irisin treatment upregulated autophagy, 8-OHdG and apoptosis in chondrocytes of the injured cartilage.	8-ohdg	40-46	fibronectin type III domain containing 5	Homo sapiens	0-6
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	196-223	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	225-231	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32312836-0	2020	MTH1 inhibitor TH588 disturbs mitotic progression and induces mitosis-dependent accumulation of genomic 8-oxodG.	8-ohdg	104-111	nudix hydrolase 1	Homo sapiens	0-4
32312836-4	2020	Here we show that replacement of one of the main DNA replicases in human cells, DNA polymerase delta (Pol delta), with an error-prone variant allows increased 8-oxodG accumulation into DNA following treatment with TH588, a dual MTH1 inhibitor (MTH1i) and microtubule targeting agent.	8-ohdg	159-166	DNA polymerase delta 1, catalytic subunit	Homo sapiens	80-100
32312836-4	2020	Here we show that replacement of one of the main DNA replicases in human cells, DNA polymerase delta (Pol delta), with an error-prone variant allows increased 8-oxodG accumulation into DNA following treatment with TH588, a dual MTH1 inhibitor (MTH1i) and microtubule targeting agent.	8-ohdg	159-166	nudix hydrolase 1	Homo sapiens	228-232
32756181-7	2020	Serum 8-OHdG level was correlated with serum ACE2, Ang(1-7) expression.	8-ohdg	6-12	angiotensin converting enzyme 2	Homo sapiens	45-49
32419286-2	2020	8-hydroxy-deoxyguanosine (8-OHdG) DNA glycosylase (OGG1) enhances the repair of 8-OHdG, which is the primary oxidative stress-induced mutation that leads to malignant alterations.	8-ohdg	0-24	8-oxoguanine DNA glycosylase	Homo sapiens	51-55
32419286-2	2020	8-hydroxy-deoxyguanosine (8-OHdG) DNA glycosylase (OGG1) enhances the repair of 8-OHdG, which is the primary oxidative stress-induced mutation that leads to malignant alterations.	8-ohdg	26-32	8-oxoguanine DNA glycosylase	Homo sapiens	51-55
32419286-2	2020	8-hydroxy-deoxyguanosine (8-OHdG) DNA glycosylase (OGG1) enhances the repair of 8-OHdG, which is the primary oxidative stress-induced mutation that leads to malignant alterations.	8-ohdg	80-86	8-oxoguanine DNA glycosylase	Homo sapiens	51-55
32419286-7	2020	The 8-OHdG was negatively correlated with OGG1 expression in HCC patients.	8-ohdg	4-10	8-oxoguanine DNA glycosylase	Homo sapiens	42-46
32756181-7	2020	Serum 8-OHdG level was correlated with serum ACE2, Ang(1-7) expression.	8-ohdg	6-12	angiopoietin 1	Homo sapiens	51-58
32487750-2	2020	Consistent with detection of characteristic oxidized guanine lesions (8-oxodG) in the treated cells, we observed significantly increased relative cII mutant frequency in the treated pre-senescent cells which was augmented in their immortalized counterparts.	8-ohdg	70-77	lambda CII family protein	Escherichia virus Lambda	146-149
32821650-3	2020	MUTYH functionally cooperates with OGG1 that eliminates 8-oxodG derived from excessive reactive oxygen species production.	8-ohdg	56-63	mutY DNA glycosylase	Homo sapiens	0-5
32821650-3	2020	MUTYH functionally cooperates with OGG1 that eliminates 8-oxodG derived from excessive reactive oxygen species production.	8-ohdg	56-63	8-oxoguanine DNA glycosylase	Homo sapiens	35-39
32616062-9	2020	Additionally, significantly positive dose-response relationships of  OH-PAHs,  HMW OH-PAH and  LMW OH-PAHs with urinary 8-OHdG or 8-iso-PGF2alpha, as well as an inverse dose-response relationship between urinary 8-OHdG and FVC, were observed (all P for trend < 0.05).	8-ohdg	120-126	cilia and flagella associated protein 97	Homo sapiens	79-82
32616062-9	2020	Additionally, significantly positive dose-response relationships of  OH-PAHs,  HMW OH-PAH and  LMW OH-PAHs with urinary 8-OHdG or 8-iso-PGF2alpha, as well as an inverse dose-response relationship between urinary 8-OHdG and FVC, were observed (all P for trend < 0.05).	8-ohdg	212-218	cilia and flagella associated protein 97	Homo sapiens	79-82
32616062-10	2020	Mediation analysis indicated that urinary 8-OHdG mediated 14.22% of the association between  HMW OH-PAH and FVC.	8-ohdg	42-48	cilia and flagella associated protein 97	Homo sapiens	93-96
32604721-5	2020	Following 3-month astaxanthin supplementation, dROM level decreased from 385.6 +- 82.6 U.CARR to 346.5 +- 56.9 U.CARR (p = 0.041) despite no changes in BAP and urinary 8-OHdG levels.	8-ohdg	168-174	Drosomycin	Drosophila melanogaster	47-51
32377713-11	2020	Furthermore, alpha2M pretreatment suppressed the expression of 8-hydroxy-2"-deoxyguanosine in mandibular bone and tongue paraffin embedded sections, which is a marker of oxidative damage, and increased SOD2 expression in mucosa and tongue paraffin embedded sections.	8-ohdg	63-90	alpha-2-macroglobulin	Rattus norvegicus	13-20
32628320-4	2020	During conditions of elevated oxidative stress, oxidative DNA damage such as modification by 8-hydroxydeoxyguanosine (8OHdG) is repaired by 8-oxoguanine glycosylase-1 (OGG-1).	8-ohdg	93-116	8-oxoguanine DNA-glycosylase 1	Mus musculus	140-166
32628320-4	2020	During conditions of elevated oxidative stress, oxidative DNA damage such as modification by 8-hydroxydeoxyguanosine (8OHdG) is repaired by 8-oxoguanine glycosylase-1 (OGG-1).	8-ohdg	93-116	8-oxoguanine DNA-glycosylase 1	Mus musculus	168-173
32443248-5	2020	Each ln-unit (ln-transformed unit) increase in  OH-PAHs in the whole year corresponded to a 34%, 16% or 23% increase in urinary 8-OHdG levels at lag0, lag1 or lag2 day as well as a 26% increase in urinary 8-OHdG levels at lag0-2 days (cumulative effects).	8-ohdg	128-134	granulysin	Homo sapiens	159-163
32547324-8	2020	Enhanced expression of 8-OHdG, HIF-1alpha was found in osteocytes following the addition of glucocorticoid in a hypoxic environment.	8-ohdg	23-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
32552911-11	2020	A significant positive relationship was found of 5-HT with SIRT3 and 8-OHdG irrespective of the gestational age and the mode of delivery.	8-ohdg	69-75	sirtuin 3	Homo sapiens	59-64
32066060-7	2020	SFPQ suppression resulted in a 36%-53% decrease in ROS generation, leading to enhanced cellular damage determined by 8-OHdG, comet tail moment, and micronucleus analysis.	8-ohdg	117-123	splicing factor proline and glutamine rich	Homo sapiens	0-4
31907970-0	2020	Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signaling.	8-ohdg	10-33	Rac family small GTPase 1	Rattus norvegicus	87-91
31907970-1	2020	BACKGROUND AND AIM: Exogenous 8-hydroxydeoxyguanosine (8-OHdG) was suggested as an inhibitor of Rac1 and NADPH oxidase (NOX).	8-ohdg	30-53	Rac family small GTPase 1	Rattus norvegicus	96-100
31907970-1	2020	BACKGROUND AND AIM: Exogenous 8-hydroxydeoxyguanosine (8-OHdG) was suggested as an inhibitor of Rac1 and NADPH oxidase (NOX).	8-ohdg	55-61	Rac family small GTPase 1	Rattus norvegicus	96-100
31907970-10	2020	RESULTS: The 8-OHdG treatment in BDL rats reduced the NOX1 and NOX2 protein expression which overlapped with alpha-SMA compared to BDL rats.	8-ohdg	13-19	NADPH oxidase 1	Rattus norvegicus	54-58
31907970-10	2020	RESULTS: The 8-OHdG treatment in BDL rats reduced the NOX1 and NOX2 protein expression which overlapped with alpha-SMA compared to BDL rats.	8-ohdg	13-19	cytochrome b-245 beta chain	Rattus norvegicus	63-67
31907970-10	2020	RESULTS: The 8-OHdG treatment in BDL rats reduced the NOX1 and NOX2 protein expression which overlapped with alpha-SMA compared to BDL rats.	8-ohdg	13-19	actin gamma 2, smooth muscle	Rattus norvegicus	115-118
31907970-11	2020	The 8-OHdG treatment in BDL rats significantly decreased the mRNA expression of NOX1, NOX2, alpha-SMA, TGF-beta1, and collagen Ialpha, and fibrotic contents.	8-ohdg	4-10	NADPH oxidase 1	Rattus norvegicus	80-84
31907970-11	2020	The 8-OHdG treatment in BDL rats significantly decreased the mRNA expression of NOX1, NOX2, alpha-SMA, TGF-beta1, and collagen Ialpha, and fibrotic contents.	8-ohdg	4-10	cytochrome b-245 beta chain	Rattus norvegicus	86-90
31907970-11	2020	The 8-OHdG treatment in BDL rats significantly decreased the mRNA expression of NOX1, NOX2, alpha-SMA, TGF-beta1, and collagen Ialpha, and fibrotic contents.	8-ohdg	4-10	actin gamma 2, smooth muscle	Rattus norvegicus	98-101
31907970-11	2020	The 8-OHdG treatment in BDL rats significantly decreased the mRNA expression of NOX1, NOX2, alpha-SMA, TGF-beta1, and collagen Ialpha, and fibrotic contents.	8-ohdg	4-10	transforming growth factor, beta 1	Rattus norvegicus	103-112
31907970-12	2020	Increases of reactive oxygen species (ROS) production, Rac1 activation, NOX1, NOX2, and fibronectin expression induced by angiotensin II in HSCs were attenuated by 8-OHdG.	8-ohdg	164-170	Rac family small GTPase 1	Rattus norvegicus	55-59
31907970-12	2020	Increases of reactive oxygen species (ROS) production, Rac1 activation, NOX1, NOX2, and fibronectin expression induced by angiotensin II in HSCs were attenuated by 8-OHdG.	8-ohdg	164-170	NADPH oxidase 1	Rattus norvegicus	72-76
31907970-12	2020	Increases of reactive oxygen species (ROS) production, Rac1 activation, NOX1, NOX2, and fibronectin expression induced by angiotensin II in HSCs were attenuated by 8-OHdG.	8-ohdg	164-170	cytochrome b-245 beta chain	Rattus norvegicus	78-82
31907970-12	2020	Increases of reactive oxygen species (ROS) production, Rac1 activation, NOX1, NOX2, and fibronectin expression induced by angiotensin II in HSCs were attenuated by 8-OHdG.	8-ohdg	164-170	fibronectin 1	Rattus norvegicus	88-99
31907970-12	2020	Increases of reactive oxygen species (ROS) production, Rac1 activation, NOX1, NOX2, and fibronectin expression induced by angiotensin II in HSCs were attenuated by 8-OHdG.	8-ohdg	164-170	angiotensinogen	Rattus norvegicus	122-136
31907970-14	2020	The 8-OHdG ameliorates liver fibrosis through the inhibition of Rac1 activation and NOX-derived ROS.	8-ohdg	4-10	Rac family small GTPase 1	Rattus norvegicus	64-68
32519072-4	2020	Bovine serum albumin (BSA) was designed as carrier protein for 8-OHdG to form 8-OHdG-BSA conjugate as the capture probe.	8-ohdg	63-69	albumin	Homo sapiens	7-20
32519072-4	2020	Bovine serum albumin (BSA) was designed as carrier protein for 8-OHdG to form 8-OHdG-BSA conjugate as the capture probe.	8-ohdg	78-84	albumin	Homo sapiens	7-20
32547733-6	2020	In results, in the process of LIRI, the levels of microRNA-155 were amplified in the vagal afferent nerves and cNTS, and this was accompanied with increases of IL-1beta, IL-6 and TNF-alpha; and 8-iso PGF2alpha and 8-OHdG.	8-ohdg	214-220	microRNA 155	Rattus norvegicus	50-62
32547733-7	2020	Application of microRNA-155 inhibitor, but not its scramble, attenuated the elevation of proinflammatory cytokines and amplification of 8-iso PGF2alpha and 8-OHdG in those nerve tissues.	8-ohdg	156-162	microRNA 155	Rattus norvegicus	15-27
32633379-0	2020	Inhibition of lncRNA-PAX8-AS1-N directly associated with VEGF/TGF-beta1/8-OhdG enhances podocyte apoptosis in diabetic nephropathy.	8-ohdg	72-78	vascular endothelial growth factor A	Homo sapiens	57-61
32633379-5	2020	In our study, we aimed to verify whether lncRNA PAX8-AS1-N involved in protecting podocyte apoptosis and directly associated with VEGF/TGF-beta1/8-OhdG levels in DN, and further investigated the detailed mechanism that PAX8-AS1-N regulated the pathological process.	8-ohdg	145-151	paired box 8	Homo sapiens	48-52
32633379-5	2020	In our study, we aimed to verify whether lncRNA PAX8-AS1-N involved in protecting podocyte apoptosis and directly associated with VEGF/TGF-beta1/8-OhdG levels in DN, and further investigated the detailed mechanism that PAX8-AS1-N regulated the pathological process.	8-ohdg	145-151	prostaglandin D2 receptor	Homo sapiens	53-56
32633379-11	2020	RESULTS: We found that the lncRNA PAX8-AS1-N was lowly expressed and high expression of VEGF/TGF-beta1/8-OhdG and high level of albuminuria in DN patients and high-glucose-treated MPC5.	8-ohdg	103-109	paired box 8	Homo sapiens	34-38
32633379-11	2020	RESULTS: We found that the lncRNA PAX8-AS1-N was lowly expressed and high expression of VEGF/TGF-beta1/8-OhdG and high level of albuminuria in DN patients and high-glucose-treated MPC5.	8-ohdg	103-109	prostaglandin D2 receptor	Homo sapiens	39-42
32633379-11	2020	RESULTS: We found that the lncRNA PAX8-AS1-N was lowly expressed and high expression of VEGF/TGF-beta1/8-OhdG and high level of albuminuria in DN patients and high-glucose-treated MPC5.	8-ohdg	103-109	vascular endothelial growth factor A	Homo sapiens	88-92
32633379-12	2020	Besides, we proved that LV-PAX8-AS1-N decreased MPC5 apoptosis and suppressed the expression of VEGF/TGF-beta1/8-OhdG in vitro experiment.	8-ohdg	111-117	paired box 8	Homo sapiens	27-31
32633379-12	2020	Besides, we proved that LV-PAX8-AS1-N decreased MPC5 apoptosis and suppressed the expression of VEGF/TGF-beta1/8-OhdG in vitro experiment.	8-ohdg	111-117	prostaglandin D2 receptor	Homo sapiens	32-35
32633379-12	2020	Besides, we proved that LV-PAX8-AS1-N decreased MPC5 apoptosis and suppressed the expression of VEGF/TGF-beta1/8-OhdG in vitro experiment.	8-ohdg	111-117	vascular endothelial growth factor A	Homo sapiens	96-100
32062073-6	2020	Furthermore, OVA challenge elevated the activation of NLRP3 inflammasome with higher protein expression of NLRP3, caspase1 and IL-1beta, enhanced oxidative stress with higher expression of 8-OHdG, nitrotyrosine and SOD2, increased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1).	8-ohdg	189-195	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	13-16
31928237-9	2020	MiRNA-21 was strongly positively correlated to the area % of 8-OHdG, while miRNA-29 was strongly positively correlated to the area % of Van Gieson staining.	8-ohdg	61-67	microRNA 21	Rattus norvegicus	0-8
32086080-10	2020	Moreover, GSTM1-null genotype enhanced O3-induced increases, albeit insignificant, in levels of serum hs-CRP, 8-OHdG, and t-PA compared with GSTM1-sufficient genotype.	8-ohdg	110-116	glutathione S-transferase mu 1	Homo sapiens	10-15
32248837-12	2020	HIF1alpha overexpression in ADSCs alleviated high glucose-induced defects in MAEC proliferation and migration and significantly suppressed ADSC ROS and 8-OHdG levels, thereby decreasing apoptosis and enhancing survival.	8-ohdg	152-158	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-9
32062073-6	2020	Furthermore, OVA challenge elevated the activation of NLRP3 inflammasome with higher protein expression of NLRP3, caspase1 and IL-1beta, enhanced oxidative stress with higher expression of 8-OHdG, nitrotyrosine and SOD2, increased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1).	8-ohdg	189-195	NLR family, pyrin domain containing 3	Mus musculus	54-59
32062372-2	2020	We aimed to investigate changes in urine 8-Oxo-2"-deoxyguanosine (8-oxo-dG) and gene expression levels of 8-Oxoguanine DNA glycosylase 1 (OGG1) during a current depressive episode and after remission in bipolar and unipolar disorders.	8-ohdg	66-74	8-oxoguanine DNA glycosylase	Homo sapiens	138-142
31995668-9	2020	Urine GRP levels correlated with duration of NICU ventilatory and oxygen support and with biomarkers of oxidative stress: allantoin and 8-hydroxydeoxyguanosine.	8-ohdg	136-159	gastrin releasing peptide	Homo sapiens	6-9
31969622-3	2020	Moreover, our results point to a role of pol mu in mediating ligation during the mutagenic bypass of 8-oxodG, while 3"-preinserted noncanonical base pairs (3"-rA or 3"-rC) on NHEJ repair intermediates compromise the end joining by DNA ligase I or the DNA ligase IV/XRCC4 complex.	8-ohdg	101-108	DNA polymerase mu	Homo sapiens	41-47
31699484-9	2020	Morpholino knockdown confirmed that AHR mediated the TCE-induced ROS and 8-OHdG generation in the heart of zebrafish embryos.	8-ohdg	73-79	aryl hydrocarbon receptor 1a	Danio rerio	36-39
32183600-5	2020	Multiple distinct mechanisms work together to decrease the genomic level of 8-OHdG through the enzymatic activities of Mutyh, Ogg1 and Mth1.	8-ohdg	76-82	mutY DNA glycosylase	Homo sapiens	119-124
32183600-5	2020	Multiple distinct mechanisms work together to decrease the genomic level of 8-OHdG through the enzymatic activities of Mutyh, Ogg1 and Mth1.	8-ohdg	76-82	8-oxoguanine DNA glycosylase	Homo sapiens	126-130
32183600-5	2020	Multiple distinct mechanisms work together to decrease the genomic level of 8-OHdG through the enzymatic activities of Mutyh, Ogg1 and Mth1.	8-ohdg	76-82	nudix hydrolase 1	Homo sapiens	135-139
31932477-5	2020	Genetic Nrf2 induction in AppNLGF mice markedly suppressed the elevation of the oxidative stress marker 8-OHdG and Iba1-positive microglial cell number.	8-ohdg	104-110	nuclear factor, erythroid derived 2, like 2	Mus musculus	8-12
31969622-0	2020	Pol mu ribonucleotide insertion opposite 8-oxodG facilitates the ligation of premutagenic DNA repair intermediate.	8-ohdg	41-48	DNA polymerase mu	Homo sapiens	0-6
31969622-2	2020	Here, we report that the pol mu insertion products of ribonucleotides (rATP or rCTP), instead of deoxyribonucleotides, opposite 8-oxo-2"-deoxyguanosine (8-oxodG) are efficiently ligated and the presence of Mn2+ stimulates this coupled reaction in vitro.	8-ohdg	128-151	DNA polymerase mu	Homo sapiens	25-31
32183375-8	2020	The enlarged cystic kidneys of PCK rats exhibited significant accumulation of 8-hydroxyguanosine (8-OHdG) as early as 4 weeks of age, which became more pronounced at 12 weeks.	8-ohdg	98-104	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	31-34
32006457-11	2020	We also detected an apparent link between SAA and 8-OHdG.	8-ohdg	50-56	serum amyloid A1 cluster	Homo sapiens	42-45
33346410-9	2020	The expression of 8-OHdG was also higher in the PRDX4 knockout than in the wild-type control group at 5 weeks, but with no statistically significant difference (P > 0.05).	8-ohdg	18-24	peroxiredoxin 4	Mus musculus	48-53
31969622-2	2020	Here, we report that the pol mu insertion products of ribonucleotides (rATP or rCTP), instead of deoxyribonucleotides, opposite 8-oxo-2"-deoxyguanosine (8-oxodG) are efficiently ligated and the presence of Mn2+ stimulates this coupled reaction in vitro.	8-ohdg	128-151	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	79-83
31463191-13	2019	Stimulation of SP6 decreased the immobility time of the FST and altered the ER stress and oxidative stress marker proteins, such as 8-OHDG, BiP, pJNK, PDI, Ero1-Ia and Calnexin.	8-ohdg	132-138	Sp6 transcription factor	Rattus norvegicus	15-18
31969622-2	2020	Here, we report that the pol mu insertion products of ribonucleotides (rATP or rCTP), instead of deoxyribonucleotides, opposite 8-oxo-2"-deoxyguanosine (8-oxodG) are efficiently ligated and the presence of Mn2+ stimulates this coupled reaction in vitro.	8-ohdg	153-160	DNA polymerase mu	Homo sapiens	25-31
31969622-2	2020	Here, we report that the pol mu insertion products of ribonucleotides (rATP or rCTP), instead of deoxyribonucleotides, opposite 8-oxo-2"-deoxyguanosine (8-oxodG) are efficiently ligated and the presence of Mn2+ stimulates this coupled reaction in vitro.	8-ohdg	153-160	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	79-83
32405345-9	2020	Conclusion: The lowered frequency of K-ras mutations correlated with decreased formation of hydroxyl radicals, O5-meG and 8-OH-dG levels in phytate-supplemented animals with lowered tumor burden.	8-ohdg	122-129	KRAS proto-oncogene, GTPase	Rattus norvegicus	37-42
31366457-7	2019	Knockdown of ZEB1 in CRC cells inhibited 8-oxo-dG induction by oxidative stress (H2O2) and inflammatory cytokines (interleukin (IL)1beta).	8-ohdg	41-49	zinc finger E-box binding homeobox 1	Mus musculus	13-17
31366457-7	2019	Knockdown of ZEB1 in CRC cells inhibited 8-oxo-dG induction by oxidative stress (H2O2) and inflammatory cytokines (interleukin (IL)1beta).	8-ohdg	41-49	interleukin 1 beta	Mus musculus	115-136
31016687-7	2019	A blockade of miR-155 also attenuated expression of NOX subtype 4 (NOX4) and thereby decreased the levels of 8-iso PGF2alpha/8-OHdG in the dorsal horn of OXL rats.	8-ohdg	125-131	microRNA 155	Rattus norvegicus	14-21
31228599-5	2019	Investigation of the role of oxidative stress pathways showed that DBP exposure could lead to a significant increase in levels of reactive oxygen species (ROS), malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and nuclear factor-kappaB (NF-kappaB), while a decrease in glutathione (GSH) levels were observed.	8-ohdg	212-218	D site albumin promoter binding protein	Mus musculus	67-70
32038143-10	2019	Results: The expression of NLRP3 and ASC were upregulated after SAH associated with elevated expression of MDA, 8-OHdG, 4-HNE, HO-1, TLR4/NF-kappaB, inflammatory and apoptotic makers.	8-ohdg	112-118	NLR family, pyrin domain containing 3	Rattus norvegicus	27-32
32038143-10	2019	Results: The expression of NLRP3 and ASC were upregulated after SAH associated with elevated expression of MDA, 8-OHdG, 4-HNE, HO-1, TLR4/NF-kappaB, inflammatory and apoptotic makers.	8-ohdg	112-118	PYD and CARD domain containing	Rattus norvegicus	37-40
31699373-0	2020	Presence of metalloproteinases 2 and 9 and 8-OHdG in the fibrotic process in skeletal muscle of Mdx mice.	8-ohdg	43-49	dystrophin, muscular dystrophy	Mus musculus	96-99
31699373-6	2020	Histopathological findings related to centralized nuclei increase were related to higher 8-OHdG immunomarked nuclei in Mdx, which signalizes oxidative stress associated with DNA damage provoked by DMD.	8-ohdg	89-95	dystrophin, muscular dystrophy	Mus musculus	119-122
31814473-7	2020	Compared to optimal health NTN-PW, levels of PlGF, VEGF-A and TAC were significantly (p &lt; 0.05) reduced and negatively associated with SHS whilst sEng, sFlt-1, 8-epiPGF2alpha, 8-OHdG, and combined ratios of sFlt-1/PlGF, 8-epiPGF2alpha/PlGF, 8-OHdG/PlGF, and sEng/PlGF were significantly increased and positively associated with SHS.	8-ohdg	179-185	placental growth factor	Homo sapiens	45-49
31814473-7	2020	Compared to optimal health NTN-PW, levels of PlGF, VEGF-A and TAC were significantly (p &lt; 0.05) reduced and negatively associated with SHS whilst sEng, sFlt-1, 8-epiPGF2alpha, 8-OHdG, and combined ratios of sFlt-1/PlGF, 8-epiPGF2alpha/PlGF, 8-OHdG/PlGF, and sEng/PlGF were significantly increased and positively associated with SHS.	8-ohdg	244-250	placental growth factor	Homo sapiens	45-49
31661292-6	2019	This is paralleled by inactivation of the AMPK and activation of the mammalian target of rapamycin (mTOR) C1 signaling pathways, resulting in 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) accumulation, induction of DNA damage, and exacerbation of cancer cell aggressiveness, thus contributing to the genomic instability and predisposition to increased tumorigenesis in the diabetic milieu.	8-ohdg	142-177	mechanistic target of rapamycin kinase	Homo sapiens	69-98
31661292-6	2019	This is paralleled by inactivation of the AMPK and activation of the mammalian target of rapamycin (mTOR) C1 signaling pathways, resulting in 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) accumulation, induction of DNA damage, and exacerbation of cancer cell aggressiveness, thus contributing to the genomic instability and predisposition to increased tumorigenesis in the diabetic milieu.	8-ohdg	142-177	mechanistic target of rapamycin kinase	Homo sapiens	100-104
31661292-6	2019	This is paralleled by inactivation of the AMPK and activation of the mammalian target of rapamycin (mTOR) C1 signaling pathways, resulting in 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) accumulation, induction of DNA damage, and exacerbation of cancer cell aggressiveness, thus contributing to the genomic instability and predisposition to increased tumorigenesis in the diabetic milieu.	8-ohdg	179-186	mechanistic target of rapamycin kinase	Homo sapiens	69-98
31661292-6	2019	This is paralleled by inactivation of the AMPK and activation of the mammalian target of rapamycin (mTOR) C1 signaling pathways, resulting in 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) accumulation, induction of DNA damage, and exacerbation of cancer cell aggressiveness, thus contributing to the genomic instability and predisposition to increased tumorigenesis in the diabetic milieu.	8-ohdg	179-186	mechanistic target of rapamycin kinase	Homo sapiens	100-104
31661292-7	2019	Pharmacologic activation of AMPK, inhibition of mTORC1, or blockade of Nox4 reduce ROS production, restore the homeostatic signaling of 8-oxoguanine DNA glycosylase/8-oxodG, and lessen the progression of CRC malignancy in a diabetic milieu.	8-ohdg	165-172	NADPH oxidase 4	Homo sapiens	71-75
31400119-2	2019	In protein-free DNA, 8-oxodG adopts the syn conformation more frequently than the anti one.	8-ohdg	21-28	synemin	Homo sapiens	40-43
31400119-3	2019	In the syn conformation, 8-oxodG base pairs with dA.	8-ohdg	25-32	synemin	Homo sapiens	7-10
31400119-4	2019	The equilibrium between the anti and syn conformations of the adduct are known to be altered by the enzyme recognizing 8-oxodG.	8-ohdg	119-126	synemin	Homo sapiens	37-40
31611883-8	2019	We also showed higher oxidative damage to DNA ( 8-OHdG), proteins ( AGE,  AOPP), and lipids ( 4-HNE,  8-isop) in both AT and NBS patients.	8-ohdg	48-54	nibrin	Homo sapiens	125-128
31611883-10	2019	However, in AT children, we showed a positive correlation between 8-OHdG and the alpha-fetoprotein level as well as a negative correlation between 8-OHdG and IgA.	8-ohdg	66-72	alpha fetoprotein	Homo sapiens	81-98
31637265-11	2019	Urinary NGAL and RBP both correlated negatively with eGFR and positively with plasma IL-6 and 8-OHdG.	8-ohdg	94-100	lipocalin 2	Homo sapiens	8-12
31637265-11	2019	Urinary NGAL and RBP both correlated negatively with eGFR and positively with plasma IL-6 and 8-OHdG.	8-ohdg	94-100	retinol binding protein 4	Homo sapiens	17-20
31134485-8	2019	Mechanistically, TBN suppressed the increase in 3-nitrotyrosine and 8-hydroxy-2-deoxyguanosine immuno-positive cells in the cortex of SAH rat brain.	8-ohdg	68-94	TATA-box binding protein associated factor 8	Rattus norvegicus	17-20
31284679-5	2019	Notably, ZNF423 expression was positively correlated with 8-oxodG formation.	8-ohdg	58-65	zinc finger protein 423	Homo sapiens	9-15
31371780-5	2019	Male HFD-Hhip +/+ mice had more large islets in which insulin content was reduced; islet architecture was disordered; and markers of oxidative stress (8-OHdG and Nox 2) were increased.	8-ohdg	151-157	Hedgehog-interacting protein	Mus musculus	9-13
31358014-9	2019	There was a significant relationship between CYP1A1 hypomethylation and high 8-OHdG (1st vs. 3rd tertile = 1.58, 95% CI: 1.01-2.47, P for trend = 0.046).	8-ohdg	77-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
31358014-10	2019	In addition, mediation analysis suggested CYP1A1 hypomethylation could explain 13.6% of effect of high 8-OHdG related to smoking and 1-OHP co-exposure.	8-ohdg	103-109	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	42-48
31164636-6	2019	Moreover, MI-743 could not only inhibit cell proliferation in up to 16 cancer cell lines, especially gastric cancer cells HGC-27 and MGC-803, but also significantly induce MTH1-related 8-oxo-dG accumulation and DNA damage.	8-ohdg	185-193	nudix hydrolase 1	Homo sapiens	172-176
30712392-8	2019	F. communis extract decreased CCl4 induced 8-OHdG formation and caspase 3 activation significantly in hepatocytes, especially at the 150 mg/kg dose.	8-ohdg	43-49	C-C motif chemokine ligand 4	Rattus norvegicus	30-34
31199854-11	2019	In human kidney biopsies, KLOTHO expression was inversely correlated with levels of oxidative stress markers (8-hydroxy-2"-deoxyguanosine: rho = -0.38, P = 0.026; 4-hydroxy-2-hexenal: rho = -0.35, P = 0.038) and miR-200c (rho = -0.34, P = 0.043).	8-ohdg	110-137	klotho	Homo sapiens	26-32
31325295-9	2019	Carriers of the variant allele (Gln) of XRCC1 had the highest levels of 1-OHP, DNA adducts and 8-OHdG, and the lowest level of CYP2E1 gene expression.	8-ohdg	95-101	X-ray repair cross complementing 1	Homo sapiens	40-45
31354343-0	2019	Urinary 8-hydroxydeoxyguanosine in relation to XRCC1 rs25487 G/A (Arg399Gln) and OGG1 rs1052133 C/G (Ser326Cys) DNA repair genes polymorphisms in patients with chronic hepatitis C and related hepatocellular carcinoma.	8-ohdg	8-31	X-ray repair cross complementing 1	Homo sapiens	47-52
31354343-0	2019	Urinary 8-hydroxydeoxyguanosine in relation to XRCC1 rs25487 G/A (Arg399Gln) and OGG1 rs1052133 C/G (Ser326Cys) DNA repair genes polymorphisms in patients with chronic hepatitis C and related hepatocellular carcinoma.	8-ohdg	8-31	8-oxoguanine DNA glycosylase	Homo sapiens	81-85
31354343-3	2019	The current study aimed to evaluate urinary 8-OHdG levels in patients with chronic hepatitis C virus (HCV) and its related hepatocellular (HCC) and correlate its level to XRCC1 rs25487 G/A and OGG1 rs1052133 C/G gene polymorphisms.	8-ohdg	44-50	X-ray repair cross complementing 1	Homo sapiens	171-176
31354343-3	2019	The current study aimed to evaluate urinary 8-OHdG levels in patients with chronic hepatitis C virus (HCV) and its related hepatocellular (HCC) and correlate its level to XRCC1 rs25487 G/A and OGG1 rs1052133 C/G gene polymorphisms.	8-ohdg	44-50	8-oxoguanine DNA glycosylase	Homo sapiens	193-197
31354343-11	2019	Additionally, XRCC1 (AA) and OGG1 (GG) genotypes had significantly increased urinary 8-OHdG levels among patients (P&lt;0.05).	8-ohdg	85-91	X-ray repair cross complementing 1	Homo sapiens	14-19
31354343-11	2019	Additionally, XRCC1 (AA) and OGG1 (GG) genotypes had significantly increased urinary 8-OHdG levels among patients (P&lt;0.05).	8-ohdg	85-91	8-oxoguanine DNA glycosylase	Homo sapiens	29-33
31354343-12	2019	Conclusions: XRCC1 (AA) and OGG1 (GG) could be considered as possible genotypic risk factors for HCV- related HCC development which were associated with significantly high urinary 8-hydroxy-deoxyguanosine levels, thus urinary 8-OHdG could be considered as non-invasive marker in follow-up chronic HCV progression into HCC.	8-ohdg	180-204	X-ray repair cross complementing 1	Homo sapiens	13-18
31354343-12	2019	Conclusions: XRCC1 (AA) and OGG1 (GG) could be considered as possible genotypic risk factors for HCV- related HCC development which were associated with significantly high urinary 8-hydroxy-deoxyguanosine levels, thus urinary 8-OHdG could be considered as non-invasive marker in follow-up chronic HCV progression into HCC.	8-ohdg	180-204	8-oxoguanine DNA glycosylase	Homo sapiens	28-32
31354343-12	2019	Conclusions: XRCC1 (AA) and OGG1 (GG) could be considered as possible genotypic risk factors for HCV- related HCC development which were associated with significantly high urinary 8-hydroxy-deoxyguanosine levels, thus urinary 8-OHdG could be considered as non-invasive marker in follow-up chronic HCV progression into HCC.	8-ohdg	226-232	8-oxoguanine DNA glycosylase	Homo sapiens	28-32
30684126-12	2019	Moreover, activation of the PI3K/Akt pathway through over-expression of Trem2 alleviated oxidative stress, as shown by the increased expression of SOD and GSH-Px and the decreased expression of MDA and 8-OHdG.	8-ohdg	202-208	thymoma viral proto-oncogene 1	Mus musculus	33-36
30684126-12	2019	Moreover, activation of the PI3K/Akt pathway through over-expression of Trem2 alleviated oxidative stress, as shown by the increased expression of SOD and GSH-Px and the decreased expression of MDA and 8-OHdG.	8-ohdg	202-208	triggering receptor expressed on myeloid cells 2	Mus musculus	72-77
30889508-5	2019	Herein, we evidenced that PrimPol Glu116 contributes to error-prone tolerance of 8oxodG more markedly when both Mg2+ and Mn2+ ions are present.	8-ohdg	81-87	primase and DNA directed polymerase	Homo sapiens	26-33
31077211-0	2019	Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population.	8-ohdg	64-88	lipase C, hepatic type	Homo sapiens	27-31
31077211-8	2019	Subgroup analyses revealed that the association of the LIPC SNPs with the levels of serum TG, HDL-C, and urinary 8-OHdG were predominantly observed in the men but not in the women.	8-ohdg	113-119	lipase C, hepatic type	Homo sapiens	55-59
30683611-8	2019	Significant positive correlations between 8-OHdG and both carcinoembryonic antigen (r = 0.63; P &lt; .001) and cancer antigen 15-3 (r = 0.51; P &lt; .001) were noticed.	8-ohdg	42-48	mucin 1, cell surface associated	Homo sapiens	111-130
31117842-9	2019	This study underlined the prognostic significance of the oxidative stress marker 8-OH-dG and BER pathway genes, especially hOGG1 and XRCC1, in gallbladder anomalies and GBC, as well as stated their potential for therapeutic targeting.	8-ohdg	81-88	8-oxoguanine DNA glycosylase	Homo sapiens	123-128
31117842-9	2019	This study underlined the prognostic significance of the oxidative stress marker 8-OH-dG and BER pathway genes, especially hOGG1 and XRCC1, in gallbladder anomalies and GBC, as well as stated their potential for therapeutic targeting.	8-ohdg	81-88	X-ray repair cross complementing 1	Homo sapiens	133-138
30575123-8	2019	8-oxo-2"-deoxyguanosine (8-OHdG) levels were higher in tumors of the IH-1 group than in that of the N and IH-2 groups.	8-ohdg	0-23	RWD domain containing 1	Mus musculus	69-73
30575123-8	2019	8-oxo-2"-deoxyguanosine (8-OHdG) levels were higher in tumors of the IH-1 group than in that of the N and IH-2 groups.	8-ohdg	25-31	RWD domain containing 1	Mus musculus	69-73
30575123-9	2019	Gene expression related to reactive oxygen species production was higher in the IH-1 group than in the N and IH-2 groups, and it showed a positive correlation with 8-OHdG levels.	8-ohdg	164-170	RWD domain containing 1	Mus musculus	80-84
30917489-9	2019	Forced miR-29a expression reduced the MCD diet exaggeration of reactive oxygen species (ROS) production by immunohistochemically staining 8-OHdG.	8-ohdg	138-144	microRNA 29a	Mus musculus	7-14
30930781-6	2019	The release of this cytokine was caspase-1- and caspase-4-dependent and correlated to higher levels of 8-OH-dG in COPD compared to non-smoker and smoker-derived PBMCs.	8-ohdg	103-110	caspase 1	Homo sapiens	33-42
30930781-6	2019	The release of this cytokine was caspase-1- and caspase-4-dependent and correlated to higher levels of 8-OH-dG in COPD compared to non-smoker and smoker-derived PBMCs.	8-ohdg	103-110	caspase 4	Homo sapiens	48-57
30703483-6	2019	OGG1, H3K9me3 and HP1alpha expression in BlCa tissues were positively correlated with 8-OHdG levels.	8-ohdg	86-92	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
30703483-6	2019	OGG1, H3K9me3 and HP1alpha expression in BlCa tissues were positively correlated with 8-OHdG levels.	8-ohdg	86-92	chromobox 5	Homo sapiens	18-26
30760709-4	2019	We found that the master hypoxia-associated miRNA miR-210-3p was increased in stromal and glandular cells of ectopic lesions compared with that of eutopic and normal endometria and was consistent with the expression of HIF-1alpha and the local oxidative stress-induced DNA damage predictor 8-OHdG.	8-ohdg	290-296	hypoxia inducible factor 1 subunit alpha	Homo sapiens	219-229
30762093-7	2019	Additionally, further analysis revealed that 8-OHdG was negatively correlated with FEV1, FEV1% predicted, and FEV1/FVC and positively correlated with C-reactive protein, procalcitonin, and neutrophil CD64.	8-ohdg	45-51	C-reactive protein	Homo sapiens	150-168
30762093-7	2019	Additionally, further analysis revealed that 8-OHdG was negatively correlated with FEV1, FEV1% predicted, and FEV1/FVC and positively correlated with C-reactive protein, procalcitonin, and neutrophil CD64.	8-ohdg	45-51	Fc gamma receptor Ia	Homo sapiens	200-204
30428137-10	2019	Moreover, 8-OHdG was expressed in the nuclei of CD31- and alpha smooth muscle actin-immunopositive cells, and the up-regulated mRNA expressions of aortic nitric oxide synthase 3 and platelet-derived growth factors were only observed in the KO mice on AD with EtOH treatment.	8-ohdg	10-16	platelet/endothelial cell adhesion molecule 1	Mus musculus	48-52
30567668-4	2019	Combine the high dispersed Pt NCs with high specific surface area and high conductivity of NGR, the CQD@PDA@PtNCs-NGR shows excellent electrocatalytic performance towards the biosensing of DNA damage biomarker- 8-Hydroxy-2"-deoxyguanosine (8-OH-dG).	8-ohdg	211-238	reticulon 4 receptor	Homo sapiens	91-94
30584969-5	2019	Adiponectin inhibited great levels of eotaxin, myeloperoxidase, tumor necrosis factor-alpha, 8-hydroxy-2"-deoxyguanosine, and nitric oxide in obesity-related asthma mice.	8-ohdg	93-120	adiponectin, C1Q and collagen domain containing	Mus musculus	0-11
30567668-4	2019	Combine the high dispersed Pt NCs with high specific surface area and high conductivity of NGR, the CQD@PDA@PtNCs-NGR shows excellent electrocatalytic performance towards the biosensing of DNA damage biomarker- 8-Hydroxy-2"-deoxyguanosine (8-OH-dG).	8-ohdg	211-238	reticulon 4 receptor	Homo sapiens	114-117
30567668-4	2019	Combine the high dispersed Pt NCs with high specific surface area and high conductivity of NGR, the CQD@PDA@PtNCs-NGR shows excellent electrocatalytic performance towards the biosensing of DNA damage biomarker- 8-Hydroxy-2"-deoxyguanosine (8-OH-dG).	8-ohdg	240-247	reticulon 4 receptor	Homo sapiens	91-94
30567668-4	2019	Combine the high dispersed Pt NCs with high specific surface area and high conductivity of NGR, the CQD@PDA@PtNCs-NGR shows excellent electrocatalytic performance towards the biosensing of DNA damage biomarker- 8-Hydroxy-2"-deoxyguanosine (8-OH-dG).	8-ohdg	240-247	reticulon 4 receptor	Homo sapiens	114-117
30567668-6	2019	The fabricated CQD@PDA@PtNCs-NGR realized the detection of 8-OH-dG in human urine practical sample.	8-ohdg	59-66	reticulon 4 receptor	Homo sapiens	29-32
30567668-7	2019	Furthermore, CQD@PDA@PtNCs-NGR was applied for the determination of 8-OH-dG generated from damaged DNA and damaged guanine (G), respectively.	8-ohdg	68-75	reticulon 4 receptor	Homo sapiens	27-30
30621167-5	2019	In addition, K36 ameliorated 8-hydroxy-2"-deoxyguanosine (8-OHdG) induced by UVA irradiation.	8-ohdg	29-56	keratin 36	Homo sapiens	13-16
30621167-5	2019	In addition, K36 ameliorated 8-hydroxy-2"-deoxyguanosine (8-OHdG) induced by UVA irradiation.	8-ohdg	58-64	keratin 36	Homo sapiens	13-16
30621196-9	2019	Also, elevation of Nkx2.1 expression was positively correlated with service length, 8-OHdG, PARP, hOGG1 and pSmad2 levels in nickel smelters.	8-ohdg	84-90	NK2 homeobox 1	Homo sapiens	19-25
30445054-8	2019	Expression of the ER stress protein glucose-regulated protein 78 (GRP78) increased in Pb-exposed rats, which was associated with high levels of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in rat brains after Pb exposure in PNW3 and PNW70 rats.	8-ohdg	144-171	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	36-64
30836777-2	2019	We aimed to investigate the role of Androgen Receptor and NKX3.1 in 8-OHdG formation and repair activation by quantitating the DNA damage using Aklides.NUK system.	8-ohdg	68-74	androgen receptor	Homo sapiens	36-53
30836777-2	2019	We aimed to investigate the role of Androgen Receptor and NKX3.1 in 8-OHdG formation and repair activation by quantitating the DNA damage using Aklides.NUK system.	8-ohdg	68-74	NK3 homeobox 1	Homo sapiens	58-64
30836777-3	2019	The data demonstrated that the loss of NKX3.1 resulted in increased oxidative DNA damage and its overexpression contributes to the removal of menadione-induced 8-OHdG damage even under oxidative stress conditions.	8-ohdg	160-166	NK3 homeobox 1	Homo sapiens	39-45
30627800-4	2019	The presence of hOGG1 leads to the division of DNA HP1 (containing 8-oxo-dG) and formation of DNA fragments 1 and 2.	8-ohdg	67-75	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
30627800-4	2019	The presence of hOGG1 leads to the division of DNA HP1 (containing 8-oxo-dG) and formation of DNA fragments 1 and 2.	8-ohdg	67-75	chromobox 5	Homo sapiens	51-54
30445054-8	2019	Expression of the ER stress protein glucose-regulated protein 78 (GRP78) increased in Pb-exposed rats, which was associated with high levels of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in rat brains after Pb exposure in PNW3 and PNW70 rats.	8-ohdg	144-171	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	66-71
30445054-8	2019	Expression of the ER stress protein glucose-regulated protein 78 (GRP78) increased in Pb-exposed rats, which was associated with high levels of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in rat brains after Pb exposure in PNW3 and PNW70 rats.	8-ohdg	173-179	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	36-64
30445054-8	2019	Expression of the ER stress protein glucose-regulated protein 78 (GRP78) increased in Pb-exposed rats, which was associated with high levels of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in rat brains after Pb exposure in PNW3 and PNW70 rats.	8-ohdg	173-179	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	66-71
30098377-7	2018	The diabetes-induced increase in urinary level of 8-hydroxydeoxyguanosine (8-OHdG) was attenuated in NLRP3 KO mice.	8-ohdg	50-73	NLR family, pyrin domain containing 3	Mus musculus	101-106
30098377-7	2018	The diabetes-induced increase in urinary level of 8-hydroxydeoxyguanosine (8-OHdG) was attenuated in NLRP3 KO mice.	8-ohdg	75-81	NLR family, pyrin domain containing 3	Mus musculus	101-106
29787640-8	2018	Proportions of 8-OHdG and PARK7/DJ-1 expressing cells were elevated in both peri-implantitis (P = .025 for 8-OHdG and P = .014 for PARK7/DJ-1) and periodontitis (P = .038 for 8-OHdG and P = .012 for PARK7/DJ-1) groups in comparison with controls.	8-ohdg	15-21	Parkinsonism associated deglycase	Homo sapiens	131-136
30248604-8	2018	A significant association between AhR expression and high 8-OHdG was also found (4th vs. 1st quartile = 2.44, 95% CI: 1.05-5.70, P for trend = 0.027).	8-ohdg	58-64	aryl hydrocarbon receptor	Homo sapiens	34-37
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	8-ohdg	13-20	fibromodulin	Homo sapiens	78-80
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	8-ohdg	13-20	fibromodulin	Homo sapiens	84-86
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	8-ohdg	125-132	fibromodulin	Homo sapiens	78-80
29603266-8	2018	RESULTS: The 8-oxodG/creatinine ratio was significantly higher in infants fed FM vs FM/BM (38.7 +- 28.7 vs 16.7 +- 12.2 nmol 8-oxodG/mmol creatinine, P < 0.0001) or BM (11.6 +- 10.4 nmol 8-oxodG/mmol creatinine, P < 0.0001).	8-ohdg	125-132	fibromodulin	Homo sapiens	78-80
30519358-2	2018	8-Hydroxydeoxyguanine (8-OH-dG) formation is a common seen type of oxidative DNA damage, which could be repaired by human oxoguanine glycosylase 1 (hOGG1).	8-ohdg	23-30	8-oxoguanine DNA glycosylase	Homo sapiens	148-153
30310528-3	2018	An increase in mtDNA damage in M-LPH-KO HepG2 cells was demonstrated by PCR-based quantitation and 8-hydroxy-2"-deoxyguanosine (8-OHdG) measurement.	8-ohdg	99-126	melanophilin	Homo sapiens	31-36
30310528-3	2018	An increase in mtDNA damage in M-LPH-KO HepG2 cells was demonstrated by PCR-based quantitation and 8-hydroxy-2"-deoxyguanosine (8-OHdG) measurement.	8-ohdg	128-134	melanophilin	Homo sapiens	31-36
29884908-8	2018	Furthermore, our study revealed that TXNIP deficiency inhibited the expression of 8-OHdG, heme oxygenase-1 (HO-1) and NADPH oxidase 4 (Nox4) in UUO kidney.	8-ohdg	82-88	thioredoxin interacting protein	Mus musculus	37-42
29758174-3	2018	Here, in 9-month-old, female cardiomyocyte-specific GPER knockout (KO) mice vs sex- and age-matched wild-type (WT) mice, we found increased cardiac oxidative stress and oxidant damage, measured as a decreased ratio of reduced glutathione to oxidized glutathione, increased 4-hydroxynonenal and 8-hydroxy-2"-deoxyguanosine (8-oxo-DG) staining, and increased expression of oxidative stress-related genes.	8-ohdg	294-321	G protein-coupled estrogen receptor 1	Mus musculus	52-56
29758174-3	2018	Here, in 9-month-old, female cardiomyocyte-specific GPER knockout (KO) mice vs sex- and age-matched wild-type (WT) mice, we found increased cardiac oxidative stress and oxidant damage, measured as a decreased ratio of reduced glutathione to oxidized glutathione, increased 4-hydroxynonenal and 8-hydroxy-2"-deoxyguanosine (8-oxo-DG) staining, and increased expression of oxidative stress-related genes.	8-ohdg	323-331	G protein-coupled estrogen receptor 1	Mus musculus	52-56
29879444-9	2018	Mitochondrial extracts from cells expressing hOGG1S326C were deficient in mitochondrial 8-oxodG incision activity, which was rescued by the OGG1 activators.	8-ohdg	88-95	8-oxoguanine DNA glycosylase	Homo sapiens	46-50
29787640-8	2018	Proportions of 8-OHdG and PARK7/DJ-1 expressing cells were elevated in both peri-implantitis (P = .025 for 8-OHdG and P = .014 for PARK7/DJ-1) and periodontitis (P = .038 for 8-OHdG and P = .012 for PARK7/DJ-1) groups in comparison with controls.	8-ohdg	15-21	Parkinsonism associated deglycase	Homo sapiens	131-136
29787640-8	2018	Proportions of 8-OHdG and PARK7/DJ-1 expressing cells were elevated in both peri-implantitis (P = .025 for 8-OHdG and P = .014 for PARK7/DJ-1) and periodontitis (P = .038 for 8-OHdG and P = .012 for PARK7/DJ-1) groups in comparison with controls.	8-ohdg	107-113	Parkinsonism associated deglycase	Homo sapiens	26-31
29787640-8	2018	Proportions of 8-OHdG and PARK7/DJ-1 expressing cells were elevated in both peri-implantitis (P = .025 for 8-OHdG and P = .014 for PARK7/DJ-1) and periodontitis (P = .038 for 8-OHdG and P = .012 for PARK7/DJ-1) groups in comparison with controls.	8-ohdg	107-113	Parkinsonism associated deglycase	Homo sapiens	32-36
29787640-8	2018	Proportions of 8-OHdG and PARK7/DJ-1 expressing cells were elevated in both peri-implantitis (P = .025 for 8-OHdG and P = .014 for PARK7/DJ-1) and periodontitis (P = .038 for 8-OHdG and P = .012 for PARK7/DJ-1) groups in comparison with controls.	8-ohdg	107-113	Parkinsonism associated deglycase	Homo sapiens	26-31
29787640-8	2018	Proportions of 8-OHdG and PARK7/DJ-1 expressing cells were elevated in both peri-implantitis (P = .025 for 8-OHdG and P = .014 for PARK7/DJ-1) and periodontitis (P = .038 for 8-OHdG and P = .012 for PARK7/DJ-1) groups in comparison with controls.	8-ohdg	107-113	Parkinsonism associated deglycase	Homo sapiens	32-36
30420132-14	2018	For example, UCHL1 increased 9.4% (1.8%, 17%) in blood 21-h post exposure to ascorbate-related OP, while urinary malondialdehyde increased 19% (3.6%, 35%) and 8-hydroxy-deoxy-guanosine increased 24% (2.9%, 48%) 21-h post exposure to ascorbate- and glutathione-related OP, respectively.	8-ohdg	159-184	ubiquitin C-terminal hydrolase L1	Homo sapiens	13-18
30272261-8	2018	The levels of nuclear Nrf2, and the mRNA levels of Nrf2-regulated antioxidant genes, were downregulated in the auditory cortex of aging rats, which was accompanied by an increase in 8-hydroxy-2"-deoxyguanosine formation, an accumulation of mtDNA 4,834-bp deletion, and neuron degeneration.	8-ohdg	182-209	NFE2 like bZIP transcription factor 2	Rattus norvegicus	51-55
30222205-5	2018	8-OHdG was significantly overexpressed in AK and BD lesions compared with surrounding non-lesional tissue, SCC lesions and the healthy controls.	8-ohdg	0-6	serpin family B member 3	Homo sapiens	107-110
29923862-7	2018	The expressions of F4/80 and neutrophil elastase-positive inflammatory cells and IL-1 and TNF-alpha cytokine levels were significantly reduced in the 8-oxo-dG group compared with the PBS group (each P &lt; 0.01).	8-ohdg	150-158	adhesion G protein-coupled receptor E1	Mus musculus	19-24
29923862-7	2018	The expressions of F4/80 and neutrophil elastase-positive inflammatory cells and IL-1 and TNF-alpha cytokine levels were significantly reduced in the 8-oxo-dG group compared with the PBS group (each P &lt; 0.01).	8-ohdg	150-158	interleukin 1 complex	Mus musculus	81-85
29923862-7	2018	The expressions of F4/80 and neutrophil elastase-positive inflammatory cells and IL-1 and TNF-alpha cytokine levels were significantly reduced in the 8-oxo-dG group compared with the PBS group (each P &lt; 0.01).	8-ohdg	150-158	tumor necrosis factor	Mus musculus	90-99
30214615-7	2018	The present study demonstrated a positive correlation between 8-OHdG and HO-1 levels (P=0.012).	8-ohdg	62-68	heme oxygenase 1	Homo sapiens	73-77
30154478-9	2018	In addition, CD46 engagement decreased the expressions of PRO-IL-1beta and NLRP3, enhanced the expression of scaffold protein GOPC, and diminished hydrogen peroxide-induced 8-OHdG, IL-1beta and IL-6 production.	8-ohdg	173-179	CD46 molecule	Homo sapiens	13-17
30233855-9	2018	OVA challenge resulted in robust increase in 3-NT, 8-isoprostane and 8OHdG in lungs, which represented oxidative damage level.	8-ohdg	69-74	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-3
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	53-80	8-oxoguanine DNA glycosylase	Homo sapiens	207-211
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	53-80	mutY DNA glycosylase	Homo sapiens	237-242
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	53-80	nudix hydrolase 1	Homo sapiens	305-319
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	53-80	nudix hydrolase 1	Homo sapiens	321-325
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	82-88	8-oxoguanine DNA glycosylase	Homo sapiens	207-211
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	82-88	mutY DNA glycosylase	Homo sapiens	237-242
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	82-88	nudix hydrolase 1	Homo sapiens	305-319
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	82-88	nudix hydrolase 1	Homo sapiens	321-325
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	183-189	8-oxoguanine DNA glycosylase	Homo sapiens	207-211
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	183-189	mutY DNA glycosylase	Homo sapiens	237-242
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	183-189	nudix hydrolase 1	Homo sapiens	305-319
30008864-1	2018	Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1).	8-ohdg	183-189	nudix hydrolase 1	Homo sapiens	321-325
29020797-9	2018	hEC-SOD also improved oxidative stress and resulted in increased renal and urinary 8-hydroxy-2"-deoxyguanosine and 8-isoprostane levels in db/db mice.	8-ohdg	83-110	superoxide dismutase 3	Homo sapiens	0-7
29704805-7	2018	Statistically significant associations were found between urinary concentrations of 8OHDG and BPA, MeP, 3,4-DHB, OH-MeP, OH-EtP, TCS, BP3, 2,4-DCP, and 2,5-DCP.	8-ohdg	84-89	BP3	Homo sapiens	134-137
29704805-10	2018	When 8OHDG was removed from the dataset, predictability of exposure variables increased in the order of: OH-EtP &gt; OH-MeP &gt; 3,4-DHB &gt; BPA &gt; 2,4-DCP &gt; MeP &gt; TCS &gt; EtP &gt; BP1 &gt; 2,5-DCP.	8-ohdg	5-10	BP1	Homo sapiens	191-194
30069482-9	2018	A positive correlation between UPIIIa/GSTpi and 8-OHdG/GSTpi was observed, but no UPIIIa/8-OHdG correlation was noted.	8-ohdg	48-54	uroplakin 3A	Homo sapiens	31-37
29732888-9	2018	The animal experiment demonstrated that Nano-C3G could effectively reduce the UVB-induced lipid peroxidation, malondialdehyde, and 8-hydroxy-2"-deoxyguanosine contents; downregulate p53, Bcl-2-associated X (Bax), and caspase-3 and -9 expression; and balance the B-cell lymphoma-2/leukemia-2 ratio.	8-ohdg	131-158	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	45-48
29582449-7	2018	Patients in groups 1 and 2 with hOGG1 Cys/Cys genotype had significantly higher 8-OHdG content in sperm DNA, lower mitochondrial copy number in spermatozoa and lower TAC in seminal plasma than those with Ser/Ser or Ser/Cys genotype.	8-ohdg	80-86	8-oxoguanine DNA glycosylase	Homo sapiens	32-37
29581224-5	2018	Brain endothelial cells displayed increased E-selectin immunoreactivity, which was accompanied by increased amyloid-beta1-42 accumulation in piriform cortex and increased cortical oxidative stress (8-OHdG immunoreactivity).	8-ohdg	198-204	selectin, endothelial cell	Mus musculus	44-54
29867441-8	2018	Our secondary objectives were to examine the associations of lamp2"s CSF concentration with CSF levels of the molecular chaperone heat shock 70-kDa protein (HSPA8), which interacts with lamp2a in CMA, and oxidative stress markers 8-hydroxy-2"-deoxyguanosine (8-OHdG), 8-isoprostane (8-ISO) and Total Antioxidant Capacity (TAC) in healthy subjects.	8-ohdg	230-257	lysosomal associated membrane protein 2	Homo sapiens	61-66
29867441-8	2018	Our secondary objectives were to examine the associations of lamp2"s CSF concentration with CSF levels of the molecular chaperone heat shock 70-kDa protein (HSPA8), which interacts with lamp2a in CMA, and oxidative stress markers 8-hydroxy-2"-deoxyguanosine (8-OHdG), 8-isoprostane (8-ISO) and Total Antioxidant Capacity (TAC) in healthy subjects.	8-ohdg	259-265	lysosomal associated membrane protein 2	Homo sapiens	61-66
29867441-8	2018	Our secondary objectives were to examine the associations of lamp2"s CSF concentration with CSF levels of the molecular chaperone heat shock 70-kDa protein (HSPA8), which interacts with lamp2a in CMA, and oxidative stress markers 8-hydroxy-2"-deoxyguanosine (8-OHdG), 8-isoprostane (8-ISO) and Total Antioxidant Capacity (TAC) in healthy subjects.	8-ohdg	259-265	heat shock protein family A (Hsp70) member 8	Homo sapiens	157-162
29463878-7	2018	In a combined analysis of GPX4 and 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, there was a negative correlation between GPX4 and 8-hydroxydeoxyguanosine (P = 0.0009).	8-ohdg	35-58	glutathione peroxidase 4	Homo sapiens	138-142
29463878-7	2018	In a combined analysis of GPX4 and 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, there was a negative correlation between GPX4 and 8-hydroxydeoxyguanosine (P = 0.0009).	8-ohdg	60-66	glutathione peroxidase 4	Homo sapiens	138-142
29463878-7	2018	In a combined analysis of GPX4 and 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, there was a negative correlation between GPX4 and 8-hydroxydeoxyguanosine (P = 0.0009).	8-ohdg	147-170	glutathione peroxidase 4	Homo sapiens	138-142
29185011-5	2018	We tested associations between 8-OHdG concentrations and urinary albumin concentration (UAC) or eGFR at baseline, and the risk of ESRD or all-cause mortality during follow-up.	8-ohdg	31-37	epidermal growth factor receptor	Homo sapiens	96-100
28826042-5	2018	significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2"-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).	8-ohdg	76-103	V-set and immunoglobulin domain containing 2	Mus musculus	202-205
28826042-5	2018	significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2"-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).	8-ohdg	105-113	V-set and immunoglobulin domain containing 2	Mus musculus	202-205
29765508-5	2018	Notably, OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes.	8-ohdg	40-47	8-oxoguanine DNA glycosylase	Homo sapiens	9-13
29765508-5	2018	Notably, OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes.	8-ohdg	40-47	microRNA 200a	Homo sapiens	78-86
29765508-6	2018	The 8-OH-dG accumulation displays a significant linear relationship with the aging biomarker p16 expression during keratinocyte senescence.	8-ohdg	4-11	cyclin dependent kinase inhibitor 2A	Homo sapiens	93-96
29497302-7	2018	A positive correlation was found between the 8-OHdG and CAT levels in both the total stroke patients (r=0.320, P&lt;0.001) and the depressed patients (r=0.300, P=0.012).	8-ohdg	45-51	catalase	Homo sapiens	56-59
29615894-2	2018	In this study, we showed that TRPC1 deletion caused striatal neuronal loss and significantly increased TUNEL-positive and 8-hydroxy-2"-deoxyguanosine (8-OHdG) staining in the striatum.	8-ohdg	122-149	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	30-35
29615894-2	2018	In this study, we showed that TRPC1 deletion caused striatal neuronal loss and significantly increased TUNEL-positive and 8-hydroxy-2"-deoxyguanosine (8-OHdG) staining in the striatum.	8-ohdg	151-157	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	30-35
29615894-6	2018	Based on the proteomic data, we revealed by Western-blot analysis that TRPC1 deletion caused ER stress as evidenced by the dysregulation of GRP78 and PERK activation-related signaling pathway, and elevated oxidative stress as suggested by increased 8-OHdG staining, increased NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUV2) and decreased protein deglycase (DJ-1), two oxidative stress-related proteins.	8-ohdg	249-255	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	71-76
29391196-8	2018	In the NOX4-/- mice, expression of these oxidative stress markers, 8-OHdG, 4-HNE, and nitrotyrosine were significantly attenuated at both timepoints.	8-ohdg	67-73	NADPH oxidase 4	Mus musculus	7-11
29497302-10	2018	Conclusion: Higher serum 8-OHdG levels at admission were found to be correlated with PSD 1 month after stroke.	8-ohdg	25-31	pleckstrin and Sec7 domain containing	Homo sapiens	85-90
29063946-8	2018	GSTM1 null genotype was associated with a positive correlation between NO x and 8-OHdG levels (p &lt; 0.05).	8-ohdg	80-86	glutathione S-transferase mu 1	Homo sapiens	0-5
29120493-8	2018	RESULTS: A significant positive correlation was found between CYP2E1 and epsilondA (p < 0.0001) as well as between CYP2E1 and 8-OHdG (p = 0.039).	8-ohdg	126-132	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	115-121
29063946-7	2018	GSTP1 was significantly associated with the south region, where the variant (AG+GG) genotype was associated with increased 8-OHdG levels as a result of NO x exposure (p &lt; 0.05).	8-ohdg	123-129	glutathione S-transferase pi 1	Homo sapiens	0-5
28039864-10	2018	In induced apical periodontitis, osteoblastic expression of SIRT6 was significantly suppressed (P = 0.001) which was associated with significantly elevated levels of LDHA (P = 0.003) and 8-OHdG (P = 0.004) and significantly enhanced recruitment of macrophages (P = 0.004).	8-ohdg	187-193	sirtuin 6	Rattus norvegicus	60-65
29129468-4	2018	Furthermore, the levels of p-PI3K, p-Akt and p-mTOR increased, while 8-OHdG, ROS production and Bcl-2/Rac1 complex formation in mitochondria reduced in both Rac1-shRNA- and NSC23766-treated rats.	8-ohdg	69-75	Rac family small GTPase 1	Rattus norvegicus	157-161
29350093-9	2018	Also, in the maternal risk group, independent associations of DBP (R2 = 0.273; beta = 0.289; p = .040) and uACR (R2 = 0.283; beta = 0.268; p = .027) with 8-OHdG were indicated.	8-ohdg	154-160	D-box binding PAR bZIP transcription factor	Homo sapiens	62-65
29434805-9	2018	The mRNA and protein expression levels of acyl-coenzyme A oxidase 3 and monocyte chemotactic protein 1, and the protein expression levels of 8-hydroxy-2"-deoxyguanosine and 4-hydroxynonenal were upregulated in the H-FABP overexpression group, while the mRNA and protein expression of peroxisome proliferator activated receptor alpha was downregulated.	8-ohdg	141-168	fatty acid binding protein 3	Homo sapiens	214-220
29434805-9	2018	The mRNA and protein expression levels of acyl-coenzyme A oxidase 3 and monocyte chemotactic protein 1, and the protein expression levels of 8-hydroxy-2"-deoxyguanosine and 4-hydroxynonenal were upregulated in the H-FABP overexpression group, while the mRNA and protein expression of peroxisome proliferator activated receptor alpha was downregulated.	8-ohdg	141-168	peroxisome proliferator activated receptor alpha	Homo sapiens	284-332
30448843-15	2018	This may implicate that HBx may act as a tumor promoter through facilitating the mutational potential of 8-oxodG thus connecting a possible link between HBV infection and liver carcinogenesis.	8-ohdg	105-112	X protein	Hepatitis B virus	24-27
29576848-2	2018	8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), which originate from DNA and RNA oxidation, were the most widely used indicators for oxidative stress.	8-ohdg	0-35	gelsolin	Homo sapiens	44-47
30448843-0	2018	Hepatitis B Virus X Protein Increases 8-Oxo-7,8-Dihydro-2"-Deoxyguanosine (8-Oxodg) Level via Repressing MTH1/ MTH2 Expression in Hepatocytes.	8-ohdg	38-73	nudix hydrolase 1	Homo sapiens	105-109
29307370-8	2018	The present study also show that CBMN cyt assay parameters and 8-OHdG levels could be affected by some endocrine hormones such as E2, fT3, fT4, GH, IGF-1, FSH, LH, TSH, PRL, but not be related to ACTH and tT levels in acute OPs poisoning.	8-ohdg	63-69	insulin like growth factor 1	Homo sapiens	148-153
30448843-0	2018	Hepatitis B Virus X Protein Increases 8-Oxo-7,8-Dihydro-2"-Deoxyguanosine (8-Oxodg) Level via Repressing MTH1/ MTH2 Expression in Hepatocytes.	8-ohdg	38-73	nudix hydrolase 15	Homo sapiens	111-115
30448843-0	2018	Hepatitis B Virus X Protein Increases 8-Oxo-7,8-Dihydro-2"-Deoxyguanosine (8-Oxodg) Level via Repressing MTH1/ MTH2 Expression in Hepatocytes.	8-ohdg	75-82	nudix hydrolase 1	Homo sapiens	105-109
30448843-0	2018	Hepatitis B Virus X Protein Increases 8-Oxo-7,8-Dihydro-2"-Deoxyguanosine (8-Oxodg) Level via Repressing MTH1/ MTH2 Expression in Hepatocytes.	8-ohdg	75-82	nudix hydrolase 15	Homo sapiens	111-115
30448843-6	2018	However, little is known as to whether HBx can regulate the expression of those enzymes and modulate the formation and accumulation of 8-oxodG in hepatocytes.	8-ohdg	135-142	X protein	Hepatitis B virus	39-42
30448843-10	2018	RESULTS: In comparison with controls, significantly higher levels of 8-oxodG were detected in the genome and culture supernatant of stable HBV-producing HepG2.2.15 cells, in the sera and liver tissues of HBV infectious mice and HBV or HBx transgenic mice, and in the sera of HBV-infected patients.	8-ohdg	69-76	X protein	Hepatitis B virus	235-238
30448843-11	2018	Expression of HBx in hepatocytes significantly increased 8-oxodG level and reduced the expression of MTH1 and MTH2 at both mRNA and protein levels.	8-ohdg	57-64	X protein	Hepatitis B virus	14-17
30448843-13	2018	Furthermore, enhancement of 8-oxodG production by HBx was reversible by overexpression of MTH1 and MTH2.	8-ohdg	28-35	X protein	Hepatitis B virus	50-53
30448843-13	2018	Furthermore, enhancement of 8-oxodG production by HBx was reversible by overexpression of MTH1 and MTH2.	8-ohdg	28-35	nudix hydrolase 1	Homo sapiens	90-94
30448843-13	2018	Furthermore, enhancement of 8-oxodG production by HBx was reversible by overexpression of MTH1 and MTH2.	8-ohdg	28-35	nudix hydrolase 15	Homo sapiens	99-103
30448843-14	2018	CONCLUSION: Our data show that HBx expression results in the accumulation of 8-oxodG in hepatocytes through inhibiting the expression of MTH1 and MTH2.	8-ohdg	77-84	X protein	Hepatitis B virus	31-34
30448843-14	2018	CONCLUSION: Our data show that HBx expression results in the accumulation of 8-oxodG in hepatocytes through inhibiting the expression of MTH1 and MTH2.	8-ohdg	77-84	nudix hydrolase 1	Homo sapiens	137-141
30448843-14	2018	CONCLUSION: Our data show that HBx expression results in the accumulation of 8-oxodG in hepatocytes through inhibiting the expression of MTH1 and MTH2.	8-ohdg	77-84	nudix hydrolase 15	Homo sapiens	146-150
28719075-4	2017	Host-derived CD133 + 8-hydroxy-2"-deoxyguanosine (8-OHdG) cells were significantly increased in livers recovered from both alcohol-fed and control recipients, but only alcohol-fed recipients demonstrated co-staining (a marker of oxidative DNA damage).	8-ohdg	21-48	prominin 1	Rattus norvegicus	13-18
30157359-5	2018	RESULTS: The concentration of CD45+ leukocytes was correlated significantly with those of CD14+ and HLA-DR+ cells in the semen (P &lt;0.01), but not that of leukocyte subsets with routine semen parameters, sperm DFI, or the percentage of 8-OHdG-positive cells.	8-ohdg	238-244	protein tyrosine phosphatase receptor type C	Homo sapiens	30-34
29259392-7	2017	Significant positive correlations were observed between the levels of HMGB1 and the levels of 8-OHdG (r = 0.422; p = 0.001) and sVAP-1 (r = 0.354; p = 0.004) and between the levels of 8-OHdG and the levels of sVAP-1 (r = 0.598; p&lt;0.0001).	8-ohdg	94-100	high mobility group box 1	Homo sapiens	70-75
29259392-7	2017	Significant positive correlations were observed between the levels of HMGB1 and the levels of 8-OHdG (r = 0.422; p = 0.001) and sVAP-1 (r = 0.354; p = 0.004) and between the levels of 8-OHdG and the levels of sVAP-1 (r = 0.598; p&lt;0.0001).	8-ohdg	184-190	high mobility group box 1	Homo sapiens	70-75
29259392-13	2017	Treatment of HRMECs with HMGB1 increased leukocyte adhesion and induced the upregulation of 8-OHdG and HO-1 and the membranous translocation of VAP-1.	8-ohdg	92-98	high mobility group box 1	Homo sapiens	25-30
32188183-6	2017	RESULTS: Ginsenoside Rb1 inhibited high glucose-induced oxidative stress by decreasing ROS and 8-OHdG levels as well as mitochondrial depolarization in SCs.	8-ohdg	95-101	RB transcriptional corepressor 1	Homo sapiens	21-24
28719075-4	2017	Host-derived CD133 + 8-hydroxy-2"-deoxyguanosine (8-OHdG) cells were significantly increased in livers recovered from both alcohol-fed and control recipients, but only alcohol-fed recipients demonstrated co-staining (a marker of oxidative DNA damage).	8-ohdg	50-56	prominin 1	Rattus norvegicus	13-18
28719075-7	2017	Culture of CD133 + cells from normal rats with medium containing 3% ethanol for 48 hours resulted in elevated mitochondrial 8-OHdG and mtDNA deletion, and ethanol exposure diminished CD133 expression but dramatically increased alpha-SMA expression.	8-ohdg	124-130	prominin 1	Rattus norvegicus	11-16
28754587-1	2017	8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, has been recently shown to exert anti-inflammatory effects through inhibition of Rac1.	8-ohdg	0-26	Rac family small GTPase 1	Mus musculus	152-156
28972162-7	2017	In addition, hpol eta, as well as another Y-family DNA polymerase, hpol kappa, accommodates RNA as one of the two strands during primer extension, mainly by inserting dNMPs opposite unmodified templates or DNA lesions, such as 8-oxo-2"-deoxyguanosine or cyclobutane pyrimidine dimer, even in the presence of an equal amount of the DNA/DNA substrate.	8-ohdg	227-250	endothelin receptor type A	Homo sapiens	18-21
27748315-6	2017	Sperm count was significantly lower whereas the fraction of sperm with abnormal morphology, the level of 8-hydroxy-2-deoxyguanosine, and sperm DNA fragmentation were significantly higher in rats treated with leptin only.	8-ohdg	105-131	leptin	Rattus norvegicus	208-214
29123531-6	2017	Moreover, lower mRNA expression of the repairing enzyme OGG1 was associated with the higher levels of 8-OH-dG compared with non-smoker and smokers.	8-ohdg	102-109	8-oxoguanine DNA glycosylase	Homo sapiens	56-60
28936535-1	2017	In DNA, 2"-deoxyguanosine (dG) is susceptible to oxidative modification by reactive oxygen species (ROS) yielding many products, one of which is 8-oxo-7,8-dihydro-2"-deoxyguanosine (dOG).	8-ohdg	145-180	dog	Drosophila melanogaster	182-185
28882896-6	2017	POLRMT also shows a high C A error rate on 8-oxo-dG templates (~10-4).	8-ohdg	43-51	RNA polymerase mitochondrial	Homo sapiens	0-6
28418604-6	2017	A single dose of UVB resulted in a significant increase in reactive oxygen species (ROS) and 8-dihydroxyguanosine (8-oxo-dG) lesions in INK4a/Arf-/- mice compared to WT mice.	8-ohdg	115-123	cyclin dependent kinase inhibitor 2A	Mus musculus	136-141
29387865-5	2017	RAGE-aptamer significantly reduced levels of 8-hydroxy-2"-deoxy-guanosine, AGEs, RAGE, proliferating nuclear antigen, cyclin D1, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), and CD31 and Mac-3, respective markers of endothelial cells and macrophages in tumors of nude mice and suppressed the proliferation and liver metastasis of malignant melanoma.	8-ohdg	45-73	MOK protein kinase	Mus musculus	0-4
29075149-10	2017	The miR-485-5p/NUDT1 axis could lead to the changes of 8-oxo-dG in GC cells.	8-ohdg	55-63	microRNA 485	Homo sapiens	4-11
29075149-10	2017	The miR-485-5p/NUDT1 axis could lead to the changes of 8-oxo-dG in GC cells.	8-ohdg	55-63	nudix hydrolase 1	Homo sapiens	15-20
28754587-1	2017	8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, has been recently shown to exert anti-inflammatory effects through inhibition of Rac1.	8-ohdg	28-34	Rac family small GTPase 1	Mus musculus	152-156
28754587-4	2017	In cultured adipocytes, 8-OHdG inhibited adipogenesis and reversed TNFalpha-induced insulin resistance.	8-ohdg	24-30	tumor necrosis factor	Mus musculus	67-75
28754587-9	2017	Both in vivo and in vitro results showed that 8-OHdG induces AMPK activation and reduces JNK activation in adipocytes.	8-ohdg	46-52	mitogen-activated protein kinase 8	Mus musculus	89-92
28615249-9	2017	In addition, urinary level of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a marker of oxidative stress, was markedly increased in aged Pod-Sirt1RNAi mice compared with aged Pod-LuciRNAi mice.	8-ohdg	30-57	sirtuin 1	Mus musculus	129-142
28615249-9	2017	In addition, urinary level of 8-hydroxy-2"-deoxyguanosine (8-OHdG), a marker of oxidative stress, was markedly increased in aged Pod-Sirt1RNAi mice compared with aged Pod-LuciRNAi mice.	8-ohdg	59-65	sirtuin 1	Mus musculus	129-142
28602912-4	2017	8-OHdG inhibits cell migration by inactivating ERM and Rho-GTPase proteins, and inhibiting focal adhesion kinase (FAK) and matrix metalloproteinases (MMPs).	8-ohdg	0-6	protein tyrosine kinase 2	Homo sapiens	91-112
28602912-4	2017	8-OHdG inhibits cell migration by inactivating ERM and Rho-GTPase proteins, and inhibiting focal adhesion kinase (FAK) and matrix metalloproteinases (MMPs).	8-ohdg	0-6	protein tyrosine kinase 2	Homo sapiens	114-117
28602912-8	2017	8-OHdG significantly decreased DCF-DA activation in Panc-1 pancreatic cancer cells and down-regulated NOXs (nox-1, nox-2, and nox-3).	8-ohdg	0-6	NADPH oxidase 1	Homo sapiens	108-113
28602912-8	2017	8-OHdG significantly decreased DCF-DA activation in Panc-1 pancreatic cancer cells and down-regulated NOXs (nox-1, nox-2, and nox-3).	8-ohdg	0-6	cytochrome b-245 beta chain	Homo sapiens	115-120
28602912-8	2017	8-OHdG significantly decreased DCF-DA activation in Panc-1 pancreatic cancer cells and down-regulated NOXs (nox-1, nox-2, and nox-3).	8-ohdg	0-6	NADPH oxidase 3	Homo sapiens	126-131
28602912-9	2017	Finally, all of these anti-migration actions of 8-OHdG resulted in significant inhibition of EMT, as evidenced by the up-regulation of ZO-1 and claudin-1 and down-regulation of vimentin.	8-ohdg	48-54	tight junction protein 1	Homo sapiens	135-139
28602912-9	2017	Finally, all of these anti-migration actions of 8-OHdG resulted in significant inhibition of EMT, as evidenced by the up-regulation of ZO-1 and claudin-1 and down-regulation of vimentin.	8-ohdg	48-54	claudin 1	Homo sapiens	144-153
28129013-11	2017	There was a significant negative correlation between the expression levels of PARP1 and OGG1 with plasma and aqueous 8-OHdG.	8-ohdg	117-123	poly(ADP-ribose) polymerase 1	Homo sapiens	78-83
29018782-9	2017	We also found a positive correlation between changes of urinary 8-OHdG and of DNA methylation at the MTHFR or the DNMT1 (P &lt; 0.05).	8-ohdg	64-70	methylenetetrahydrofolate reductase	Homo sapiens	101-106
29018782-9	2017	We also found a positive correlation between changes of urinary 8-OHdG and of DNA methylation at the MTHFR or the DNMT1 (P &lt; 0.05).	8-ohdg	64-70	DNA methyltransferase 1	Homo sapiens	114-119
28129013-11	2017	There was a significant negative correlation between the expression levels of PARP1 and OGG1 with plasma and aqueous 8-OHdG.	8-ohdg	117-123	8-oxoguanine DNA glycosylase	Homo sapiens	88-92
28625358-8	2017	The concentrations of blood and urine 8-OHdG, and the expressions of MCP-1 and TNF-alpha mRNA were increased significantly in the XOR+/+IR mice compared to those in the XOR+/-IR mice.	8-ohdg	38-44	xanthine dehydrogenase	Mus musculus	130-133
28820464-1	2017	The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2"-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice.	8-ohdg	94-121	8-oxoguanine DNA-glycosylase 1	Mus musculus	26-50
28820464-1	2017	The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2"-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice.	8-ohdg	94-121	8-oxoguanine DNA-glycosylase 1	Mus musculus	52-56
28820464-1	2017	The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2"-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice.	8-ohdg	94-121	MOB kinase activator 2	Mus musculus	58-61
28820464-1	2017	The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2"-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice.	8-ohdg	123-129	8-oxoguanine DNA-glycosylase 1	Mus musculus	26-50
28820464-1	2017	The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2"-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice.	8-ohdg	123-129	8-oxoguanine DNA-glycosylase 1	Mus musculus	52-56
28820464-1	2017	The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2"-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice.	8-ohdg	123-129	MOB kinase activator 2	Mus musculus	58-61
28624767-7	2017	Simultaneously, knockdown of NRF1 suppressed the transcription and translation levels of SOD, GPx and CAT, decreased glutathione level and increased 8-OHdG level.	8-ohdg	149-155	nuclear respiratory factor 1	Capra hircus	29-33
28319890-10	2017	The observed changes of urinary 8-oxo-dG levels correlate positively with its serum concentration, the lipid peroxidation products MDA and F2-IsoPs, triglycerides, glucose, insulin, HOMA index and body weight and negatively with the percentage of weight and BMI loss and antioxidant activities.	8-ohdg	32-40	insulin	Homo sapiens	173-180
28342843-7	2017	We found that the 8-OHdG level in the islets from NR4A1 knockout mice fed with high-fat diet was much higher than that in the islets from parental control mice; and higher apoptotic rate was observed in the islets from NR4A1 KO mice compared to control mice.	8-ohdg	18-24	nuclear receptor subfamily 4, group A, member 1	Mus musculus	50-55
28750017-9	2017	A significant decrease of 8-OHdG levels was observed in Tg mice treated with CRFR1 antagonist.	8-ohdg	26-32	corticotropin releasing hormone receptor 1	Mus musculus	77-82
28342843-7	2017	We found that the 8-OHdG level in the islets from NR4A1 knockout mice fed with high-fat diet was much higher than that in the islets from parental control mice; and higher apoptotic rate was observed in the islets from NR4A1 KO mice compared to control mice.	8-ohdg	18-24	nuclear receptor subfamily 4, group A, member 1	Mus musculus	219-224
28617334-6	2017	The decrease of the NIS protein level observed in the cells subjected to the lowest absorbed dose was paralleled by a significant increase in 8-oxo-dG concentrations (p &lt; 0.01) and followed by late activation of the DNA repair pathways.	8-ohdg	142-150	solute carrier family 5 member 5	Homo sapiens	20-23
28465655-10	2017	3-nitrotyrosine, advanced glycation end products (AGEs), and 8-hydroxy-2"-deoxyguanosine (8-OHdG), markers for oxidatively damaged proteins and DNA, were also found to accumulate in the RPE of these mice.	8-ohdg	61-88	ribulose-5-phosphate-3-epimerase	Mus musculus	186-189
28641500-2	2017	8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) are oxidatively generated products of DNA and RNA, respectively.	8-ohdg	0-35	gelsolin	Homo sapiens	44-47
29440786-8	2017	Levels of 8-OHdG and HbA1c in CP-D patients also showed a greater reduction, 3 months after SRP when compared to CP patients (P &lt; 0.05).	8-ohdg	10-16	carboxypeptidase D	Homo sapiens	30-34
29440786-9	2017	Conclusions: GCF 8-OHdG levels, HbA1c levels, and clinical parameters were reduced significantly in CP and CP-D patients, with maximum reduction achieved in CP-D patients 3 months after SRP.	8-ohdg	17-23	carboxypeptidase D	Homo sapiens	107-111
28174045-10	2017	Statistically significant positive associations were found between 8OHDG and the concentration of the sum of phthalate metabolites, sum of DEHP metabolites, mEP, mIBP, mBP, monomethyl phthalate, mono(3-carboxypropyl) phthalate, monobenzyl phthalate, monocarboxyoctyl phthalate, monocarboxynonyl phthalate, monoisopentyl phthalate, and mono-n-propyl phthalate.	8-ohdg	67-72	myelin basic protein	Mus musculus	168-171
28486105-4	2017	CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to interact with the damage-induced base 8-hydroxydeoxyguanosine (8-OHdG), while ZMYND8 recruits it to double-strand breaks.	8-ohdg	116-139	chromodomain helicase DNA binding protein 4	Homo sapiens	0-4
28486105-4	2017	CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to interact with the damage-induced base 8-hydroxydeoxyguanosine (8-OHdG), while ZMYND8 recruits it to double-strand breaks.	8-ohdg	116-139	8-oxoguanine DNA glycosylase	Homo sapiens	49-53
28486105-4	2017	CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to interact with the damage-induced base 8-hydroxydeoxyguanosine (8-OHdG), while ZMYND8 recruits it to double-strand breaks.	8-ohdg	141-147	chromodomain helicase DNA binding protein 4	Homo sapiens	0-4
28486105-4	2017	CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to interact with the damage-induced base 8-hydroxydeoxyguanosine (8-OHdG), while ZMYND8 recruits it to double-strand breaks.	8-ohdg	141-147	8-oxoguanine DNA glycosylase	Homo sapiens	49-53
28266569-2	2017	Oxidative DNA bases modified by reactive oxygen species (ROS), primarily as 7, 8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG), which is repaired by 8-oxoguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.	8-ohdg	76-112	8-oxoguanine DNA glycosylase	Homo sapiens	144-173
28420983-5	2017	8-OHdG and 8-ISO levels were increased in LRRK2 CTL subjects, while TAC was similar between groups.	8-ohdg	0-6	leucine rich repeat kinase 2	Homo sapiens	42-47
28175985-3	2017	Hence, we investigated associations (1) between PAH exposure and IgE levels and asthma in children and (2) between PAH exposure and the oxidative stress marker 8OHdG potentially involved in disease pathogenesis stratifying by (3) sex-based differences.	8-ohdg	160-165	phenylalanine hydroxylase	Homo sapiens	115-118
28175985-8	2017	A mediation analysis was conducted to evaluate whether the risk of increased IgE and asthma related to PAH exposure is explained by 8OHdG changes.	8-ohdg	132-137	immunoglobulin heavy constant epsilon	Homo sapiens	77-80
28175985-8	2017	A mediation analysis was conducted to evaluate whether the risk of increased IgE and asthma related to PAH exposure is explained by 8OHdG changes.	8-ohdg	132-137	phenylalanine hydroxylase	Homo sapiens	103-106
28175985-13	2017	It is estimated that 35% of the effect of PAH exposure on asthma is mediated by 8OHdG levels.	8-ohdg	80-85	phenylalanine hydroxylase	Homo sapiens	42-45
28266569-2	2017	Oxidative DNA bases modified by reactive oxygen species (ROS), primarily as 7, 8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG), which is repaired by 8-oxoguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.	8-ohdg	76-112	8-oxoguanine DNA glycosylase	Homo sapiens	175-179
27840165-1	2017	OBJECTIVE: To investigate whether a single nucleotide polymorphism (SNP) rs1136410 in the poly (ADP-ribose) polymerase-1 (PARP-1) gene was associated with PARP activities, 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels, and the risk of age-related cataract (ARC) in a Chinese Han population.	8-ohdg	172-199	poly(ADP-ribose) polymerase 1	Homo sapiens	122-128
28344559-6	2017	Angiotensin II infusion significantly increased plasma oxidative stress compared to baseline (8-hydroxydeoxyguanosine; +17%; advanced oxidation protein products; +16%), nitrotyrosine (+76%).	8-ohdg	94-117	angiotensinogen	Homo sapiens	0-14
28069523-6	2017	Contrary to our hypothesis, 24h excretion of 8-oxodG/8-oxoGuo (markers of DNA/RNA damage from oxidation) was reduced in CORT-treated young animals, whereas old animals showed no significant differences.	8-ohdg	45-52	cortistatin	Rattus norvegicus	120-124
27840165-1	2017	OBJECTIVE: To investigate whether a single nucleotide polymorphism (SNP) rs1136410 in the poly (ADP-ribose) polymerase-1 (PARP-1) gene was associated with PARP activities, 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels, and the risk of age-related cataract (ARC) in a Chinese Han population.	8-ohdg	172-199	poly(ADP-ribose) polymerase 1	Homo sapiens	122-126
27840165-1	2017	OBJECTIVE: To investigate whether a single nucleotide polymorphism (SNP) rs1136410 in the poly (ADP-ribose) polymerase-1 (PARP-1) gene was associated with PARP activities, 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels, and the risk of age-related cataract (ARC) in a Chinese Han population.	8-ohdg	201-207	poly(ADP-ribose) polymerase 1	Homo sapiens	90-120
27840165-1	2017	OBJECTIVE: To investigate whether a single nucleotide polymorphism (SNP) rs1136410 in the poly (ADP-ribose) polymerase-1 (PARP-1) gene was associated with PARP activities, 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels, and the risk of age-related cataract (ARC) in a Chinese Han population.	8-ohdg	201-207	poly(ADP-ribose) polymerase 1	Homo sapiens	122-128
27840165-1	2017	OBJECTIVE: To investigate whether a single nucleotide polymorphism (SNP) rs1136410 in the poly (ADP-ribose) polymerase-1 (PARP-1) gene was associated with PARP activities, 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels, and the risk of age-related cataract (ARC) in a Chinese Han population.	8-ohdg	201-207	poly(ADP-ribose) polymerase 1	Homo sapiens	122-126
27321203-9	2017	The TA IL-6 was positively correlated with 8-OHdG levels on the 1st day (r = 0.64, p &lt; 0.05) and 28th day of life (r = 0.76, p &lt; 0.05).	8-ohdg	43-49	interleukin 6	Homo sapiens	7-11
28203077-3	2017	The device was able to detect 8-OHdG concentrations in phosphate buffer saline as low as 1.73 ng mL-1 with a dynamic range of 1-200 ng mL-1.	8-ohdg	30-36	L1 cell adhesion molecule	Mus musculus	97-101
28203077-3	2017	The device was able to detect 8-OHdG concentrations in phosphate buffer saline as low as 1.73 ng mL-1 with a dynamic range of 1-200 ng mL-1.	8-ohdg	30-36	L1 cell adhesion molecule	Mus musculus	135-139
27862062-0	2017	Paper-based solid-phase microextraction for analysis of 8-hydroxy-2"-deoxyguanosine in urine sample by CE-LIF.	8-ohdg	56-83	LIF interleukin 6 family cytokine	Homo sapiens	106-109
27862062-1	2017	An easy-to-do paper-based solid-phase microextraction (p-SPME) was developed for determination of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine sample by CE-LIF.	8-ohdg	98-125	LIF interleukin 6 family cytokine	Homo sapiens	157-160
27862062-1	2017	An easy-to-do paper-based solid-phase microextraction (p-SPME) was developed for determination of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine sample by CE-LIF.	8-ohdg	127-133	LIF interleukin 6 family cytokine	Homo sapiens	157-160
27862062-5	2017	Comparing with the untreated sample, the p-SPME can significantly reduce the interference to the separation of 8-OHdG by CE-LIF.	8-ohdg	111-117	LIF interleukin 6 family cytokine	Homo sapiens	124-127
28161061-9	2017	8OHdG was only significantly lower in preterm controls compared to term controls (p = 0.01) and correlated with SIRT1 in all samples (r = 0.27).	8-ohdg	0-5	sirtuin 1	Homo sapiens	112-117
27814627-5	2017	High IL-10 (p=0.014), IL-23 (p&lt;0.001), IFN-gamma (p&lt;0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p&lt;0.001), INF-gamma (p&lt;0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA.	8-ohdg	106-112	interleukin 10	Homo sapiens	5-10
27815257-5	2017	TGF-beta1 treatment also caused depletion of endogenous SIRT3, which paralleled with increased production of reactive oxygen species (ROS), DNA damage, and subsequent reduction in levels of 8-oxoguanine DNA glycosylase (OGG1), an enzyme that hydrolyzes oxidized guanine (8-oxo-dG) and thus protects DNA from oxidative damage.	8-ohdg	271-279	transforming growth factor, beta 1	Mus musculus	0-9
27815257-5	2017	TGF-beta1 treatment also caused depletion of endogenous SIRT3, which paralleled with increased production of reactive oxygen species (ROS), DNA damage, and subsequent reduction in levels of 8-oxoguanine DNA glycosylase (OGG1), an enzyme that hydrolyzes oxidized guanine (8-oxo-dG) and thus protects DNA from oxidative damage.	8-ohdg	271-279	sirtuin 3	Mus musculus	56-61
27814627-5	2017	High IL-10 (p=0.014), IL-23 (p&lt;0.001), IFN-gamma (p&lt;0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p&lt;0.001), INF-gamma (p&lt;0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA.	8-ohdg	106-112	interferon gamma	Homo sapiens	42-51
27814627-5	2017	High IL-10 (p=0.014), IL-23 (p&lt;0.001), IFN-gamma (p&lt;0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p&lt;0.001), INF-gamma (p&lt;0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA.	8-ohdg	106-112	C-C motif chemokine ligand 2	Homo sapiens	69-74
27814627-5	2017	High IL-10 (p=0.014), IL-23 (p&lt;0.001), IFN-gamma (p&lt;0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p&lt;0.001), INF-gamma (p&lt;0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA.	8-ohdg	106-112	interleukin 23 subunit alpha	Homo sapiens	122-127
27814627-5	2017	High IL-10 (p=0.014), IL-23 (p&lt;0.001), IFN-gamma (p&lt;0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p&lt;0.001), INF-gamma (p&lt;0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA.	8-ohdg	106-112	C-X-C motif chemokine ligand 10	Homo sapiens	166-171
27814627-5	2017	High IL-10 (p=0.014), IL-23 (p&lt;0.001), IFN-gamma (p&lt;0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p&lt;0.001), INF-gamma (p&lt;0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA.	8-ohdg	106-112	C-C motif chemokine ligand 2	Homo sapiens	186-191
28785378-1	2017	The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA glycosylase (Ogg1) responsible for the repair of 8-hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	212-239	8-oxoguanine DNA-glycosylase 1	Mus musculus	176-180
28660009-5	2017	Baseline (T0) 8-oxodG was higher in CAD than in CTR (p = 0.035).	8-ohdg	12-21	calcitonin receptor	Homo sapiens	48-51
28010926-6	2017	Multiple regression analysis between DNA methylation, DNA damage, and PM10 exposure showed that PM10 was significantly associated with oxidative DNA damage; a 1% increase in 5mC at all CpG sites in PARP1 promoter was associated with a 35% increase in 8-OHdG, while a 1% increase at 1, 2, and 3 CpG sites resulted in 38, 9, and 56% increments, respectively.	8-ohdg	251-257	poly(ADP-ribose) polymerase 1	Homo sapiens	198-203
28785378-4	2017	This was coordinated with PB-induced significant elevation of 8-OHdG formation in DNA and cell proliferation in adjacent liver of Ogg1-/- mice.	8-ohdg	62-68	8-oxoguanine DNA-glycosylase 1	Mus musculus	130-134
28785378-1	2017	The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA glycosylase (Ogg1) responsible for the repair of 8-hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	241-247	8-oxoguanine DNA-glycosylase 1	Mus musculus	176-180
28250323-4	2017	Human oxoguanine glycosylase (hOGG1) shows base excision activity for 8-oxo-dG in duplex DNA.	8-ohdg	70-78	8-oxoguanine DNA glycosylase	Homo sapiens	30-35
28798861-7	2017	The protein expression of Brg1 in lung tissue decreased to a minimum at 6 h. Overexpression of Brg1 alleviated lung injury and decreased the amounts of oxidative products, including the levels of 8-isoprostane and ROS, as well as the percentage of positive cells for 4-hydroxynonenal (4-HNE) and 8-oxo-2"-deoxyguanosine (8-OHdG).	8-ohdg	296-319	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	26-30
28798861-7	2017	The protein expression of Brg1 in lung tissue decreased to a minimum at 6 h. Overexpression of Brg1 alleviated lung injury and decreased the amounts of oxidative products, including the levels of 8-isoprostane and ROS, as well as the percentage of positive cells for 4-hydroxynonenal (4-HNE) and 8-oxo-2"-deoxyguanosine (8-OHdG).	8-ohdg	296-319	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	95-99
28798861-7	2017	The protein expression of Brg1 in lung tissue decreased to a minimum at 6 h. Overexpression of Brg1 alleviated lung injury and decreased the amounts of oxidative products, including the levels of 8-isoprostane and ROS, as well as the percentage of positive cells for 4-hydroxynonenal (4-HNE) and 8-oxo-2"-deoxyguanosine (8-OHdG).	8-ohdg	321-327	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	26-30
28798861-7	2017	The protein expression of Brg1 in lung tissue decreased to a minimum at 6 h. Overexpression of Brg1 alleviated lung injury and decreased the amounts of oxidative products, including the levels of 8-isoprostane and ROS, as well as the percentage of positive cells for 4-hydroxynonenal (4-HNE) and 8-oxo-2"-deoxyguanosine (8-OHdG).	8-ohdg	321-327	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	95-99
29362666-7	2017	From the perspective of hepatoprotection, VCAF exhibited a significant protective effect on t-BHP-induced HepG2 cell injury, as indicated by reductions in cytotoxicity and the levels of ROS, 8-hydroxydeoxyguanosine (8-OHdG), and protein carbonyls.	8-ohdg	191-214	host cell factor C1	Homo sapiens	42-46
29362666-7	2017	From the perspective of hepatoprotection, VCAF exhibited a significant protective effect on t-BHP-induced HepG2 cell injury, as indicated by reductions in cytotoxicity and the levels of ROS, 8-hydroxydeoxyguanosine (8-OHdG), and protein carbonyls.	8-ohdg	216-222	host cell factor C1	Homo sapiens	42-46
27816939-2	2016	A prevalent lesion that occurs in mtDNA damage is the formation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), which can cause mutations when not repaired properly by 8-oxoguanine DNA glycosylase (Ogg1).	8-ohdg	67-94	8-oxoguanine DNA-glycosylase 1	Mus musculus	191-195
27816939-2	2016	A prevalent lesion that occurs in mtDNA damage is the formation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), which can cause mutations when not repaired properly by 8-oxoguanine DNA glycosylase (Ogg1).	8-ohdg	96-102	8-oxoguanine DNA-glycosylase 1	Mus musculus	191-195
27816939-7	2016	In vitro experiments demonstrated that O-GlcNAcylation inhibits Ogg1 activity, which could explain the mtDNA lesion accumulation observed in vivo Reducing Ogg1 O-GlcNAcylation in vivo by introducing a dominant negative O-GlcNAc transferase mutant (F460A) restored Ogg1 enzymatic activity and, consequently, reduced 8-OHdG and mtDNA damage despite the adverse hyperglycemic milieu.	8-ohdg	315-321	8-oxoguanine DNA-glycosylase 1	Mus musculus	64-68
27816939-7	2016	In vitro experiments demonstrated that O-GlcNAcylation inhibits Ogg1 activity, which could explain the mtDNA lesion accumulation observed in vivo Reducing Ogg1 O-GlcNAcylation in vivo by introducing a dominant negative O-GlcNAc transferase mutant (F460A) restored Ogg1 enzymatic activity and, consequently, reduced 8-OHdG and mtDNA damage despite the adverse hyperglycemic milieu.	8-ohdg	315-321	8-oxoguanine DNA-glycosylase 1	Mus musculus	155-159
27816939-7	2016	In vitro experiments demonstrated that O-GlcNAcylation inhibits Ogg1 activity, which could explain the mtDNA lesion accumulation observed in vivo Reducing Ogg1 O-GlcNAcylation in vivo by introducing a dominant negative O-GlcNAc transferase mutant (F460A) restored Ogg1 enzymatic activity and, consequently, reduced 8-OHdG and mtDNA damage despite the adverse hyperglycemic milieu.	8-ohdg	315-321	8-oxoguanine DNA-glycosylase 1	Mus musculus	155-159
27769710-12	2016	8-Oxo-dG levels positively correlated with R-cdA and S-cdA levels for prediabetes and newly diagnosed T2DM.	8-ohdg	0-8	cytidine deaminase	Homo sapiens	45-48
27995963-7	2016	Knockout of Ogg1 in detrusor cells resulted in accumulation of reactive oxygen mediated 8-Oxo-dG and spontaneous pyroptotic signaling.	8-ohdg	88-96	8-oxoguanine DNA-glycosylase 1	Mus musculus	12-16
27927222-11	2016	Tollip deletion also aggravated LPS-induced oxidative and nitrosative damages, as indicated by an increase of 8-oxo-2"-deoxyguanosine and nitrotyrosine immunostaining, respectively.	8-ohdg	110-133	toll interacting protein	Mus musculus	0-6
27808329-6	2016	The geometric mean concentrations of urinary BPA, TCS and 8-OHdG were 1.08 mug L-1, 1.34 mug L-1 and 1.90 mug L-1, respectively.	8-ohdg	58-64	immunoglobulin kappa variable 1-16	Homo sapiens	79-82
27808329-6	2016	The geometric mean concentrations of urinary BPA, TCS and 8-OHdG were 1.08 mug L-1, 1.34 mug L-1 and 1.90 mug L-1, respectively.	8-ohdg	58-64	immunoglobulin kappa variable 1-16	Homo sapiens	93-102
27808329-6	2016	The geometric mean concentrations of urinary BPA, TCS and 8-OHdG were 1.08 mug L-1, 1.34 mug L-1 and 1.90 mug L-1, respectively.	8-ohdg	58-64	immunoglobulin kappa variable 1-16	Homo sapiens	93-96
27769710-12	2016	8-Oxo-dG levels positively correlated with R-cdA and S-cdA levels for prediabetes and newly diagnosed T2DM.	8-ohdg	0-8	cytidine deaminase	Homo sapiens	55-58
27906613-6	2016	In contrast to the elevated levels of UA, the daily excretion of 8-OHdG, an oxidative stress marker, was lower in Uox KO mice.	8-ohdg	65-71	urate oxidase	Mus musculus	114-117
27158980-7	2016	Also TXN expression level was negatively correlated with serum 8-OHdG and tail moment in both AML (P = 0.042 and 0.047, respectively) and ALL (P &lt; 0.001 and P = 0.02, respectively) while it showed no correlation with treatment outcome in either groups.	8-ohdg	63-69	thioredoxin	Homo sapiens	5-8
27660390-14	2016	These results suggest that the different sugar backbones between 8-oxo-rG and 8-oxo-dG alter the capacity of TLS and repair of 8-oxoguanine.	8-ohdg	78-86	FUS RNA binding protein	Homo sapiens	109-112
27435790-8	2016	There was also a statistically significant correlation between the individual values of the plasma 8-OHdG (POP2) versus IL-1beta (POP2) for the MC and LC patients (r = 0.25, p = 0.01).	8-ohdg	99-105	pyrin domain containing 2	Homo sapiens	107-111
27435790-10	2016	A new finding with possible clinical relevance is a correlation between the individual plasma values of the 8-OHdG versus anti-inflammatory interleukin IL-10 and 8-OHdG versus IL-1beta (proinflammatory) in the MC and LC patients suggesting that inflammation and oxidative stress are related.	8-ohdg	108-114	interleukin 10	Homo sapiens	152-157
27435790-10	2016	A new finding with possible clinical relevance is a correlation between the individual plasma values of the 8-OHdG versus anti-inflammatory interleukin IL-10 and 8-OHdG versus IL-1beta (proinflammatory) in the MC and LC patients suggesting that inflammation and oxidative stress are related.	8-ohdg	108-114	interleukin 1 beta	Homo sapiens	176-184
27153514-4	2016	The 8-hydroxy-2"-deoxyguanosine (8-OHdG) expression identified spermatozoa with DNA oxidative adducts while terminal deoxynucleotidyl transferase (TdT)-mediated fluorescein-dUTP nick end labeling (TUNEL) assay detected spermatozoa with DNA fragmentation.	8-ohdg	4-31	DNA nucleotidylexotransferase	Homo sapiens	147-150
27903993-12	2016	The levels of klotho were negatively correlated with 8-hydroxydeoxyguanosine and malondialdehyde levels.	8-ohdg	53-76	Klotho	Rattus norvegicus	14-20
27041572-8	2016	Consequently, HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2"-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 and/or Sirt6.	8-ohdg	72-99	poly(ADP-ribose) polymerase 1	Homo sapiens	162-167
27722009-7	2016	Finally, loss of SIRT3 in cisplatin-exposed cells removed the protective effect of PARP1 inhibition against oxidative stress, represented by the concentration of lipid hydroperoxide and 8-hydroxy-2"-deoxyguanosine; and necrotic cell death represented by a percentage of propidium iodide-positively stained cells.	8-ohdg	186-213	sirtuin 3	Homo sapiens	17-22
27722009-7	2016	Finally, loss of SIRT3 in cisplatin-exposed cells removed the protective effect of PARP1 inhibition against oxidative stress, represented by the concentration of lipid hydroperoxide and 8-hydroxy-2"-deoxyguanosine; and necrotic cell death represented by a percentage of propidium iodide-positively stained cells.	8-ohdg	186-213	poly(ADP-ribose) polymerase 1	Homo sapiens	83-88
28033692-7	2016	There was a statistical relationship between the presence of cagA, babA factors, and high serum level of 8-OHdG (P&lt;0.05).	8-ohdg	105-111	S100 calcium binding protein A8	Homo sapiens	61-65
28033692-8	2016	The presence of cagA and babA virulence factors may be associated with increased serum 8-OHdG in dyspeptic patients and may induce the damage to gastric cells.	8-ohdg	87-93	S100 calcium binding protein A8	Homo sapiens	16-20
27575995-5	2016	Multiple linear regression analysis was used to examine the relationship between log-transformed urinary 8-OH-dG and total PA (TPA) and PA of moderate/vigorous intensity (MVPA; &gt;=3 metabolic equivalents), with adjustment for age, body mass index, energy intake, alcohol consumption, smoking status, daily coffee drinking, menopause status (in women), and TPA (for MVPA).	8-ohdg	105-112	plasminogen activator, tissue type	Homo sapiens	127-130
27575995-6	2016	On multivariate adjustment, urinary 8-OH-dG levels were inversely correlated with TPA (beta = -0.020, P &lt; 0.01) in women, and this correlation was not changed by PA intensity.	8-ohdg	36-43	plasminogen activator, tissue type	Homo sapiens	82-85
27575995-9	2016	In conclusion, greater TPA in women and greater MVPA in men were correlated with reduction in urinary 8-OH-dG, suggesting sex-specific effects of MVPA and TPA on protection from oxidative DNA damage.	8-ohdg	102-109	plasminogen activator, tissue type	Homo sapiens	23-26
27575995-9	2016	In conclusion, greater TPA in women and greater MVPA in men were correlated with reduction in urinary 8-OH-dG, suggesting sex-specific effects of MVPA and TPA on protection from oxidative DNA damage.	8-ohdg	102-109	plasminogen activator, tissue type	Homo sapiens	155-158
27693327-4	2016	In this study, the interactions between the Nrf2-ARE signalling pathway and SVCV replication were investigated, which demonstrated that SVCV infection induced accumulation of ROS as well as protein carbonyl groups and 8-OHdG, accompanied by the up-regulation of Nrf2 and its downstream genes.	8-ohdg	218-224	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
27803873-6	2016	We concluded that the observed increase in MDA and 8-OHdG levels may be correlated with decreased PON1 activity.	8-ohdg	51-57	paraoxonase 1	Homo sapiens	98-102
27585947-11	2016	The urinary 8-oxodGuo levels from the MTH1 mice (both knock-out and hMTH1-Tg) were not significantly different to the wild-type mice.	8-ohdg	12-21	nudix (nucleoside diphosphate linked moiety X)-type motif 1	Mus musculus	38-42
27533346-2	2016	We detected a strong NOX2 immunoreactivity, mainly in cortical GABAergic neurons and astrocytes, with a minor presence in microglia, glutamatergic and dopaminergic neurons as well as a significant immunostaining for other markers of oxidative stress (8OhDG, HSP70, HSP90, and NF-kappaB) and apoptotic phenomena.	8-ohdg	251-256	cytochrome b-245 beta chain	Homo sapiens	21-25
27451029-7	2016	Treatment by DNC, showing superiority to curcumin, effectively counteracted these effects and reduced DNA damage as determined via 8-OHdG levels and lipid peroxidation as measured by the level of TBARS (as well as lipid hydroperoxides and 8-isoprostane).	8-ohdg	131-137	solute carrier family 25 member 19	Homo sapiens	13-16
27481934-0	2016	A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG.	8-ohdg	76-84	DNA polymerase lambda	Homo sapiens	24-45
27481934-2	2016	In order to maintain genomic integrity, post-replicative 8-oxo-dG:dA mispairs are removed through DNA polymerase lambda (Pol lambda)-dependent MUTYH-initiated base excision repair (BER).	8-ohdg	57-65	DNA polymerase lambda	Homo sapiens	98-119
27481934-2	2016	In order to maintain genomic integrity, post-replicative 8-oxo-dG:dA mispairs are removed through DNA polymerase lambda (Pol lambda)-dependent MUTYH-initiated base excision repair (BER).	8-ohdg	57-65	mutY DNA glycosylase	Homo sapiens	143-148
27481934-4	2016	We demonstrate that Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn-conformation.	8-ohdg	76-84	synemin	Homo sapiens	108-111
27465136-11	2016	Oxidative DNA damage (8-oxodG) increased in young Sod(-/-) mice and with age in all mice.	8-ohdg	22-29	superoxide dismutase 1, soluble	Mus musculus	50-53
27239406-8	2016	GDF-15 levels were associated with 8-oxo-dG in the circulation of patients consistent with a role for oxidative stress in the production of this protein.	8-ohdg	35-43	growth differentiation factor 15	Homo sapiens	0-6
26875698-7	2016	RESULTS: We found that aspartate aminotransferase/alanine aminotransferase ratio, the fibrosis-4 index, and serum alpha-fetoprotein (AFP) level were associated with degree of 8-OHdG, and AFP was an independent factor among them (P = 0.0271).	8-ohdg	175-181	alpha fetoprotein	Homo sapiens	114-131
26875698-7	2016	RESULTS: We found that aspartate aminotransferase/alanine aminotransferase ratio, the fibrosis-4 index, and serum alpha-fetoprotein (AFP) level were associated with degree of 8-OHdG, and AFP was an independent factor among them (P = 0.0271).	8-ohdg	175-181	alpha fetoprotein	Homo sapiens	133-136
26875698-7	2016	RESULTS: We found that aspartate aminotransferase/alanine aminotransferase ratio, the fibrosis-4 index, and serum alpha-fetoprotein (AFP) level were associated with degree of 8-OHdG, and AFP was an independent factor among them (P = 0.0271).	8-ohdg	175-181	alpha fetoprotein	Homo sapiens	187-190
27383448-9	2016	8-Hydroxy-2"-deoxyguanosine was formed in the cells treated with AgNPs, which was augmented by UVA irradiation, suggesting that intracellular oxidation caused oxidative DNA damage, leading to the enhanced formation of DSBs and gamma-H2AX.	8-ohdg	0-27	H2A.X variant histone	Homo sapiens	227-237
26567049-6	2016	Furthermore, the renal cortex of DN (Dahl salt-resistant normotensive) + IS, DH (Dahl salt-sensitive hypertensive), and DH + IS rats showed increased expression of NF-kappaB p65, CYP24, 8-hydroxydeoxyguanosine (8-OHdG), a marker of ROS and macrophage infiltration compared with DN rats.	8-ohdg	211-217	nuclear factor kappa B subunit 1	Homo sapiens	164-173
27436759-7	2016	Statistically significant increases were observed for 8-oxo-dG and 1,N(6)-epsilondA concentrations in hepatic DNA of female rats exposed to the binary mixture (1000 ng/kg/day + 1000 mug/kg/day) but not in rats exposed to PCB 126 (1000 ng/kg/day) or PCB 153 (1000 mug/kg/day) for 14 and 31 wks.	8-ohdg	54-62	pyruvate carboxylase	Rattus norvegicus	221-224
27436759-7	2016	Statistically significant increases were observed for 8-oxo-dG and 1,N(6)-epsilondA concentrations in hepatic DNA of female rats exposed to the binary mixture (1000 ng/kg/day + 1000 mug/kg/day) but not in rats exposed to PCB 126 (1000 ng/kg/day) or PCB 153 (1000 mug/kg/day) for 14 and 31 wks.	8-ohdg	54-62	pyruvate carboxylase	Rattus norvegicus	249-252
26359225-9	2016	The findings are especially meaningful for participants with risk factors such as high urinary total arsenic, inefficient arsenic methylation indices, high urinary 8-OHdG, and the high-risk G-G haplotype of hOGG1 which are all associated with an increased UC risk.	8-ohdg	164-170	8-oxoguanine DNA glycosylase	Homo sapiens	207-212
26438402-2	2016	Our previous work demonstrated that environmentally relevant arsenic exposures generate an accelerated accumulation of pre-carcinogen 8-OH-dG DNA lesions under Ogg1-deficient backgrounds, but it remains unproved whether this observed arsenic-induced oxidative DNA damage (ODD) is certainly important in terms of cancer.	8-ohdg	134-141	8-oxoguanine DNA glycosylase	Homo sapiens	160-164
26980281-4	2016	We demonstrate that during BER of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP with the formation of 8-oxodG:C and 8-oxodG:A mispairs.	8-ohdg	48-55	polymerase (DNA directed), beta	Mus musculus	75-94
27260513-0	2016	8-Oxo-7,8-dihydro-2"-deoxyguanosine and other lesions along the coding strand of the exon 5 of the tumour suppressor gene P53 in a breast cancer case-control study.	8-ohdg	0-35	tumor protein p53	Homo sapiens	122-125
27260513-3	2016	We detected a significant "in vitro" generation of 8-oxodG between the codons 163 and 175, corresponding to a TP53 region with high mutation prevalence, after treatment with xanthine plus xanthine oxidase, a ROS-generating system.	8-ohdg	51-58	tumor protein p53	Homo sapiens	110-114
27268735-6	2016	T2DM classification accuracy increased if 8-hydroxy-2-deoxyguanosine (8-OhdG), an oxidative stress marker, was included in the algorithm from 78.71% for HbA1c at 6.5% to 86.64%.	8-ohdg	42-68	hemoglobin subunit alpha 1	Homo sapiens	153-157
27268735-6	2016	T2DM classification accuracy increased if 8-hydroxy-2-deoxyguanosine (8-OhdG), an oxidative stress marker, was included in the algorithm from 78.71% for HbA1c at 6.5% to 86.64%.	8-ohdg	70-76	hemoglobin subunit alpha 1	Homo sapiens	153-157
27507943-3	2016	This study investigated age-related alteration in cerebrospinal fluid (CSF) concentrations of heat shock 70-kDa protein 8 (HSPA8), a molecular chaperone involved in proteostatic mechanisms including chaperone-mediated autophagy, and its associations with indicators of oxidative stress (8-hydroxy-2"-deoxyguanosine [8-OHdG] and 8-isoprostane) and total anti-oxidant capacity.	8-ohdg	287-314	heat shock protein family A (Hsp70) member 8	Homo sapiens	94-121
27507943-3	2016	This study investigated age-related alteration in cerebrospinal fluid (CSF) concentrations of heat shock 70-kDa protein 8 (HSPA8), a molecular chaperone involved in proteostatic mechanisms including chaperone-mediated autophagy, and its associations with indicators of oxidative stress (8-hydroxy-2"-deoxyguanosine [8-OHdG] and 8-isoprostane) and total anti-oxidant capacity.	8-ohdg	287-314	heat shock protein family A (Hsp70) member 8	Homo sapiens	123-128
27507943-3	2016	This study investigated age-related alteration in cerebrospinal fluid (CSF) concentrations of heat shock 70-kDa protein 8 (HSPA8), a molecular chaperone involved in proteostatic mechanisms including chaperone-mediated autophagy, and its associations with indicators of oxidative stress (8-hydroxy-2"-deoxyguanosine [8-OHdG] and 8-isoprostane) and total anti-oxidant capacity.	8-ohdg	316-322	heat shock protein family A (Hsp70) member 8	Homo sapiens	94-121
27507943-3	2016	This study investigated age-related alteration in cerebrospinal fluid (CSF) concentrations of heat shock 70-kDa protein 8 (HSPA8), a molecular chaperone involved in proteostatic mechanisms including chaperone-mediated autophagy, and its associations with indicators of oxidative stress (8-hydroxy-2"-deoxyguanosine [8-OHdG] and 8-isoprostane) and total anti-oxidant capacity.	8-ohdg	316-322	heat shock protein family A (Hsp70) member 8	Homo sapiens	123-128
27507943-7	2016	HSPA8 was moderately negatively associated with 8-OHdG (rho = -0.58; p = 0.0004).	8-ohdg	48-54	heat shock protein family A (Hsp70) member 8	Homo sapiens	0-5
26980281-4	2016	We demonstrate that during BER of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP with the formation of 8-oxodG:C and 8-oxodG:A mispairs.	8-ohdg	48-55	polymerase (DNA directed), beta	Mus musculus	96-104
26980281-4	2016	We demonstrate that during BER of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP with the formation of 8-oxodG:C and 8-oxodG:A mispairs.	8-ohdg	122-129	polymerase (DNA directed), beta	Mus musculus	75-94
26980281-4	2016	We demonstrate that during BER of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP with the formation of 8-oxodG:C and 8-oxodG:A mispairs.	8-ohdg	122-129	polymerase (DNA directed), beta	Mus musculus	96-104
26980281-4	2016	We demonstrate that during BER of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP with the formation of 8-oxodG:C and 8-oxodG:A mispairs.	8-ohdg	122-129	polymerase (DNA directed), beta	Mus musculus	75-94
26980281-4	2016	We demonstrate that during BER of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP with the formation of 8-oxodG:C and 8-oxodG:A mispairs.	8-ohdg	122-129	polymerase (DNA directed), beta	Mus musculus	96-104
27294914-7	2016	Moreover, ginsenoside Rg1 down-regulated advanced glycation end products (AGEs), 4-hydroxynonenal (4-HNE), phospho-histone H2A.X (r-H2A.X), 8-OHdG, p16(Ink4a), Rb, p21(Cip1/Waf1) and p53 in senescent Sca-1+ HSC/HPCs.	8-ohdg	140-146	protein phosphatase 1, regulatory subunit 3A	Mus musculus	22-25
26899729-6	2016	In the short-term study, although 8-hydroxydeoxyguanosine (8-OHdG) levels in the epithelial DNA of Nrf2(-/-) mice at the high dose were significantly lower than those of the corresponding Nrf2(+/+) mice, the difference was very small.	8-ohdg	34-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
27070823-7	2016	Levels of 8-hydroxy-deoxyguanosine were increased in periodontal lesions of Nrf2(-/-) mice, indicating high oxidative damage.	8-ohdg	10-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
26899729-6	2016	In the short-term study, although 8-hydroxydeoxyguanosine (8-OHdG) levels in the epithelial DNA of Nrf2(-/-) mice at the high dose were significantly lower than those of the corresponding Nrf2(+/+) mice, the difference was very small.	8-ohdg	59-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
26489884-6	2016	In addition, modified nucleosides such as 7-methylguanosine, 8-hydroxyguanosine (8-OHG) and 8-hydroxydeoxyguanosine (8-OHdG) activated TLR7 with ORNs.	8-ohdg	92-115	toll like receptor 7	Homo sapiens	135-139
26489884-6	2016	In addition, modified nucleosides such as 7-methylguanosine, 8-hydroxyguanosine (8-OHG) and 8-hydroxydeoxyguanosine (8-OHdG) activated TLR7 with ORNs.	8-ohdg	117-123	toll like receptor 7	Homo sapiens	135-139
26489884-9	2016	In conclusion, our results provide evidence that G, dG, 8-OHG and 8-OHdG are novel endogenous ligands for TLR7.	8-ohdg	66-72	toll like receptor 7	Homo sapiens	106-110
26654345-3	2016	In this study, the associations between salivary 8-OHdG and IL-17 levels and clinical and microbial parameters before and after non-surgical treatment are investigated.	8-ohdg	49-55	interleukin 17A	Homo sapiens	60-65
27107066-9	2016	There was a significant inverse correlation between the individual values of the plasma hs-CRP and 8-OHdG in patients with benign disease and cancer (r=-0.40, p=0.02).	8-ohdg	99-105	C-reactive protein	Homo sapiens	91-94
27107066-12	2016	A new finding with possible clinical relevance is a significant inverse correlation between the individual plasma values of the hs-CRP and 8-OHdG in patients with benign disease and cancer.	8-ohdg	139-145	C-reactive protein	Homo sapiens	131-134
26654345-13	2016	CONCLUSIONS: There was a strong association between salivary 8-OHdG and IL-17 levels and periodontitis.	8-ohdg	61-67	interleukin 17A	Homo sapiens	72-77
27032448-8	2016	MMC exposure resulted in oxidative DNA damage, evidenced by accumulation of 8-oxo-2"-deoxyguanosine (8-oxodG) and a decrease in the level of 8-oxodG repair protein OGG1 in the PFC of female animals 3 weeks after treatment.	8-ohdg	141-148	8-oxoguanine DNA-glycosylase 1	Mus musculus	164-168
27316582-0	2016	Correlating blood levels of 8-hydroxydeoxyguanosine to hOGG1 genotypes and the incidence of ischemic cardiomyopathy.	8-ohdg	28-51	8-oxoguanine DNA glycosylase	Homo sapiens	55-60
26984527-5	2016	In addition, PolDIP2 stimulates both the efficiency and error-free bypass of 8-oxo-7,8-dihydrodeoxyguanosine (8-oxoG) lesions by PrimPol.	8-ohdg	77-108	DNA polymerase delta interacting protein 2	Homo sapiens	13-20
26984527-5	2016	In addition, PolDIP2 stimulates both the efficiency and error-free bypass of 8-oxo-7,8-dihydrodeoxyguanosine (8-oxoG) lesions by PrimPol.	8-ohdg	77-108	primase and DNA directed polymerase	Homo sapiens	129-136
26984527-5	2016	In addition, PolDIP2 stimulates both the efficiency and error-free bypass of 8-oxo-7,8-dihydrodeoxyguanosine (8-oxoG) lesions by PrimPol.	8-ohdg	110-116	DNA polymerase delta interacting protein 2	Homo sapiens	13-20
26984527-5	2016	In addition, PolDIP2 stimulates both the efficiency and error-free bypass of 8-oxo-7,8-dihydrodeoxyguanosine (8-oxoG) lesions by PrimPol.	8-ohdg	110-116	primase and DNA directed polymerase	Homo sapiens	129-136
26942876-5	2016	8-OHdG expression was associated with the TNM stages.	8-ohdg	0-6	teneurin transmembrane protein 1	Homo sapiens	42-45
26873966-10	2016	Along with Sirt3, we also observed a concomitant decrease in levels of oxoguanine-DNA glycosylase-1 (OGG1), a major DNA glycosylase that hydrolyzes oxidized-guanine (8-oxo-dG) to guanine.	8-ohdg	166-174	8-oxoguanine DNA-glycosylase 1	Mus musculus	71-99
26873966-10	2016	Along with Sirt3, we also observed a concomitant decrease in levels of oxoguanine-DNA glycosylase-1 (OGG1), a major DNA glycosylase that hydrolyzes oxidized-guanine (8-oxo-dG) to guanine.	8-ohdg	166-174	8-oxoguanine DNA-glycosylase 1	Mus musculus	101-105
27069125-0	2016	Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2"-deoxyguanosine and Nitrotyrosine in Melanoma.	8-ohdg	62-89	kelch like ECH associated protein 1	Homo sapiens	5-10
26629949-4	2016	Untreated +/- brca1-deficient embryos developed normally, but when exposed to EtOH exhibited increased levels of oxidatively damaged DNA, measured as 8-oxo-2"-deoxyguanosine, gammaH2AX, which is a marker of DNA double strand breaks that can result from 8-oxo-2"-deoxyguanosine, formation, and embryopathies at EtOH concentrations that did not affect their brca1-normal littermates.	8-ohdg	150-173	BRCA1 DNA repair associated	Homo sapiens	14-19
27073625-2	2016	Glycosylase hOGG1 can remove the mutagenic lesion 8-oxodG from DNA.	8-ohdg	50-57	8-oxoguanine DNA glycosylase	Homo sapiens	12-17
25731970-1	2016	The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2"-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100).	8-ohdg	195-222	X-ray repair cross complementing 1	Homo sapiens	117-157
25731970-1	2016	The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2"-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100).	8-ohdg	224-230	X-ray repair cross complementing 1	Homo sapiens	117-157
26629949-4	2016	Untreated +/- brca1-deficient embryos developed normally, but when exposed to EtOH exhibited increased levels of oxidatively damaged DNA, measured as 8-oxo-2"-deoxyguanosine, gammaH2AX, which is a marker of DNA double strand breaks that can result from 8-oxo-2"-deoxyguanosine, formation, and embryopathies at EtOH concentrations that did not affect their brca1-normal littermates.	8-ohdg	253-276	BRCA1 DNA repair associated	Homo sapiens	14-19
26872394-3	2016	The 2"-deoxyadenosine derivative with a diazaphenoxazine skeleton at the 6-amino group (Adap) was shown to be selective for 8-oxo-dG in DNA.	8-ohdg	124-132	FYN binding protein 1	Homo sapiens	88-92
26740629-6	2016	Here, we show that hpol eta maintains base selectivity when incorporating rNTPs opposite undamaged DNA and the DNA lesions 7,8-dihydro-8-oxo-2"-deoxyguanosine and cyclobutane pyrimidine dimer but with rates that are 10(3)-fold lower than for inserting the corresponding dNTPs.	8-ohdg	123-158	endothelin receptor type A	Homo sapiens	24-27
26740629-7	2016	X-ray crystal structures show that the hpol eta scaffolds the incoming rNTP to pair with the template base (dG) or 7,8-dihydro-8-oxo-2"-deoxyguanosine with a significant propeller twist.	8-ohdg	115-150	endothelin receptor type A	Homo sapiens	44-47
26732620-16	2016	In both animal models the protection provided by the novel antioxidant was statistically significant (P &lt; 0.01 for the reduction of 8OHdG in the spermatozoa of Gpx5 KO mice and P &lt; 0.05 for increase in fertility in the scrotal heat stress model).	8-ohdg	135-140	glutathione peroxidase 5	Mus musculus	163-167
26885927-7	2016	Furthermore, immunostaining intensity of 4-HNE and 8-OHdG, markers of oxidative stress damage attenuated by Keap1-tat peptide as compared with vehicle group in CA1 region.	8-ohdg	51-57	carbonic anhydrase 1	Rattus norvegicus	160-163
25354798-8	2016	Oxidatively damaged DNA determined as 8-oxo-2"-deoxyguanosine (8-oxodGuo), which is repaired by OGG1, was measured in single embryos in vivo after maternal EtOH treatment (4 g/kg i.p).	8-ohdg	38-61	8-oxoguanine DNA-glycosylase 1	Mus musculus	96-100
25354798-8	2016	Oxidatively damaged DNA determined as 8-oxo-2"-deoxyguanosine (8-oxodGuo), which is repaired by OGG1, was measured in single embryos in vivo after maternal EtOH treatment (4 g/kg i.p).	8-ohdg	63-72	8-oxoguanine DNA-glycosylase 1	Mus musculus	96-100
25354798-9	2016	EtOH increased embryonic 8-oxodGuo in an ogg1 gene-dependent fashion, with the highest levels in -/- embryos.	8-ohdg	25-34	8-oxoguanine DNA-glycosylase 1	Mus musculus	41-45
27980269-3	2016	Simultaneous with an increase in the expression of Wilms" Tumor 1 (WT1) gene in the peripheral blood, the serum dROM level was elevated, and this increase was observed earlier than the increases in ferritin and 8-OHdG.	8-ohdg	211-217	WT1 transcription factor	Homo sapiens	51-65
26799210-8	2016	In addition, the inhibition of NOS2 and NOS3 resulted in a significant decrease in VEGF-induced hemosiderin, nitrotyrosine- and 8-OHdG positive cells at PN7.	8-ohdg	128-134	nitric oxide synthase 2, inducible	Mus musculus	31-35
26799210-8	2016	In addition, the inhibition of NOS2 and NOS3 resulted in a significant decrease in VEGF-induced hemosiderin, nitrotyrosine- and 8-OHdG positive cells at PN7.	8-ohdg	128-134	nitric oxide synthase 3, endothelial cell	Mus musculus	40-44
26799210-8	2016	In addition, the inhibition of NOS2 and NOS3 resulted in a significant decrease in VEGF-induced hemosiderin, nitrotyrosine- and 8-OHdG positive cells at PN7.	8-ohdg	128-134	vascular endothelial growth factor A	Mus musculus	83-87
26729415-7	2016	However, a DCFH-DA assay and 8OHdG staining revealed that LCN2 reduced intracellular levels of reactive oxygen species and DNA damage.	8-ohdg	29-34	lipocalin 2	Homo sapiens	58-62
26408804-7	2016	Finally, TERT was localized in mitochondria in tumor and peritumor samples, with 8-OHdG levels significantly lower in mitochondrial than those in genomic DNA (P = 0.0003).	8-ohdg	81-87	telomerase reverse transcriptase	Homo sapiens	9-13
30090390-4	2016	Compared with the NBE population, the STAT3 methylation level (P = 0.001), Platelets (PLTs) (P = 0.002) and 8-isoprostane-PGFs (8-iso-PGF2a) (P = 0.001) manifested a significant reduction, while ALT (P = 0.002) and 8-hydroxy-2 deoxyguanosine (8-OHdG) (P = 0.002) showed a significant rise in the LDBE population.	8-ohdg	215-241	signal transducer and activator of transcription 3	Homo sapiens	38-43
30090390-4	2016	Compared with the NBE population, the STAT3 methylation level (P = 0.001), Platelets (PLTs) (P = 0.002) and 8-isoprostane-PGFs (8-iso-PGF2a) (P = 0.001) manifested a significant reduction, while ALT (P = 0.002) and 8-hydroxy-2 deoxyguanosine (8-OHdG) (P = 0.002) showed a significant rise in the LDBE population.	8-ohdg	243-249	signal transducer and activator of transcription 3	Homo sapiens	38-43
30090390-5	2016	In addition, a significant correlation was observed between STAT3 methylation and oxidative stress, namely 8-OhdG and 8-iso-PGF2a.	8-ohdg	107-113	signal transducer and activator of transcription 3	Homo sapiens	60-65
26650478-3	2016	Herein, we present an ADC(2)-s ab initio study of the neutral and the anionic form of 8-oxo-deoxyguanosine, for each of which we have considered the intramolecularly 5"-O-H   N3 hydrogen-bonded syn conformer.	8-ohdg	86-106	synemin	Homo sapiens	194-197
27980269-3	2016	Simultaneous with an increase in the expression of Wilms" Tumor 1 (WT1) gene in the peripheral blood, the serum dROM level was elevated, and this increase was observed earlier than the increases in ferritin and 8-OHdG.	8-ohdg	211-217	WT1 transcription factor	Homo sapiens	67-70
27980269-3	2016	Simultaneous with an increase in the expression of Wilms" Tumor 1 (WT1) gene in the peripheral blood, the serum dROM level was elevated, and this increase was observed earlier than the increases in ferritin and 8-OHdG.	8-ohdg	211-217	Drosomycin	Drosophila melanogaster	112-116
27980269-4	2016	Throughout the clinical course, dROM and 8-OHdG correlated significantly with WT1 and with ferritin, suggesting that changes in the oxidative stress marker levels reflect not only iron overload but also disease progression of MDS.	8-ohdg	41-47	WT1 transcription factor	Homo sapiens	78-81
25384549-4	2016	Intracellular levels of reactive oxygen species, 8-hydroxy-2"-deoxyguanosine, malondialdehyde, and carbonyl were significantly enhanced, and activities of respiratory complexes I and III and ATP level were significantly decreased in NaDC3-infected cells.	8-ohdg	49-76	solute carrier family 13 member 3	Homo sapiens	233-238
27213030-4	2016	The older XPA patients demonstrated an increase in the urinary levels of 8-hydroxy-2"-deoxyguanosine and hexanoyl-lysine, a marker of oxidative DNA damage and lipid peroxidation, having a robust peak at 6:00 and 18:00, respectively.	8-ohdg	73-100	XPA, DNA damage recognition and repair factor	Homo sapiens	10-13
26635910-0	2016	Higher Urinary Levels of 8-Hydroxy-2"-deoxyguanosine Are Associated with a Worse RANKL/OPG Ratio in Postmenopausal Women with Osteopenia.	8-ohdg	25-52	TNF superfamily member 11	Homo sapiens	81-86
26635910-0	2016	Higher Urinary Levels of 8-Hydroxy-2"-deoxyguanosine Are Associated with a Worse RANKL/OPG Ratio in Postmenopausal Women with Osteopenia.	8-ohdg	25-52	TNF receptor superfamily member 11b	Homo sapiens	87-90
26635910-4	2016	In the attempt to address this issue, we sought to determine if OxS, as assessed by 8-hydroxy-2-deoxyguanosine (8-OHdG), may influence the level of receptor activator of nuclear factor-kappab ligand (RANKL)/osteoprotegerin (OPG) ratio (a central regulator of bone metabolism) in a sample (n = 124), including postmenopausal women with osteoporosis, osteopenia and normal bone mass density (BMD).	8-ohdg	84-110	TNF superfamily member 11	Homo sapiens	148-198
26635910-4	2016	In the attempt to address this issue, we sought to determine if OxS, as assessed by 8-hydroxy-2-deoxyguanosine (8-OHdG), may influence the level of receptor activator of nuclear factor-kappab ligand (RANKL)/osteoprotegerin (OPG) ratio (a central regulator of bone metabolism) in a sample (n = 124), including postmenopausal women with osteoporosis, osteopenia and normal bone mass density (BMD).	8-ohdg	84-110	TNF superfamily member 11	Homo sapiens	200-205
26635910-4	2016	In the attempt to address this issue, we sought to determine if OxS, as assessed by 8-hydroxy-2-deoxyguanosine (8-OHdG), may influence the level of receptor activator of nuclear factor-kappab ligand (RANKL)/osteoprotegerin (OPG) ratio (a central regulator of bone metabolism) in a sample (n = 124), including postmenopausal women with osteoporosis, osteopenia and normal bone mass density (BMD).	8-ohdg	84-110	TNF receptor superfamily member 11b	Homo sapiens	207-222
26635910-4	2016	In the attempt to address this issue, we sought to determine if OxS, as assessed by 8-hydroxy-2-deoxyguanosine (8-OHdG), may influence the level of receptor activator of nuclear factor-kappab ligand (RANKL)/osteoprotegerin (OPG) ratio (a central regulator of bone metabolism) in a sample (n = 124), including postmenopausal women with osteoporosis, osteopenia and normal bone mass density (BMD).	8-ohdg	84-110	TNF receptor superfamily member 11b	Homo sapiens	224-227
26635910-4	2016	In the attempt to address this issue, we sought to determine if OxS, as assessed by 8-hydroxy-2-deoxyguanosine (8-OHdG), may influence the level of receptor activator of nuclear factor-kappab ligand (RANKL)/osteoprotegerin (OPG) ratio (a central regulator of bone metabolism) in a sample (n = 124), including postmenopausal women with osteoporosis, osteopenia and normal bone mass density (BMD).	8-ohdg	112-118	TNF superfamily member 11	Homo sapiens	148-198
26454081-9	2015	Inhibition of mGluR5 protected against neurotoxicity by mitigating oxidative stress-related DNA damage associated with 8-hydroxy-2"-deoxyguanosine production and also reduced p-ERK activity and Trx2 expression.	8-ohdg	119-146	glutamate receptor, ionotropic, kainate 1	Mus musculus	14-20
27648120-10	2016	The increase of CatB was accompanied with an increase of 8-hydroxy-2"-deoxyguanosine (8-OHdG) and a decrease of IkappaBalpha.	8-ohdg	57-84	cathepsin B	Homo sapiens	16-20
27648120-10	2016	The increase of CatB was accompanied with an increase of 8-hydroxy-2"-deoxyguanosine (8-OHdG) and a decrease of IkappaBalpha.	8-ohdg	86-92	cathepsin B	Homo sapiens	16-20
30090359-4	2016	Free radicals could then attack guanine and induce 8-hydroxy-deoxyguanine (8-OHdG) generation, causing DNA strand breakage, the inhibition of topoisomerase II (topo II) activity, and alter PCNA, Gadd45 and topo II gene expression.	8-ohdg	75-81	proliferating cell nuclear antigen	Homo sapiens	189-193
26520687-9	2015	It was also demonstrated that T2DM patients with higher median of urinary 8-OHdG had significantly elevated levels of IL-6, TNF-alpha and HOMA-IR, and decreased IL-10 levels.	8-ohdg	74-80	interleukin 6	Homo sapiens	118-122
26520687-9	2015	It was also demonstrated that T2DM patients with higher median of urinary 8-OHdG had significantly elevated levels of IL-6, TNF-alpha and HOMA-IR, and decreased IL-10 levels.	8-ohdg	74-80	tumor necrosis factor	Homo sapiens	124-133
26520687-9	2015	It was also demonstrated that T2DM patients with higher median of urinary 8-OHdG had significantly elevated levels of IL-6, TNF-alpha and HOMA-IR, and decreased IL-10 levels.	8-ohdg	74-80	interleukin 10	Homo sapiens	161-166
26520687-10	2015	Our findings showed that T2DM patients with higher urinary 8-OHdG levels showed a greater inflammatory degree and higher insulin resistance.	8-ohdg	59-65	insulin	Homo sapiens	121-128
26577825-5	2015	Probiotic soy milk significantly decreased promoter methylation in proximal and distal MLH1 promoter region (P &lt; 0.01 and P &lt; 0.0001, respectively) compared with the baseline values, while plasma concentration of 8-hydroxy-2"-deoxyguanosine (8-OHdG) decreased significantly compared with soy milk (P &lt; 0.05).	8-ohdg	219-246	mutL homolog 1	Homo sapiens	87-91
26604653-10	2015	The reduction of urinary 8-OHdG was significantly correlated with decreased levels of both ALT and gamma-GTP [ 8-OHdG and  ALT: Spearman r (r) 0.514 and P = 0.012,  8-OHdG and  gamma-GTP: r = 0.496 and P = 0.016].	8-ohdg	25-31	inactive glutathione hydrolase 2	Homo sapiens	99-108
26604653-10	2015	The reduction of urinary 8-OHdG was significantly correlated with decreased levels of both ALT and gamma-GTP [ 8-OHdG and  ALT: Spearman r (r) 0.514 and P = 0.012,  8-OHdG and  gamma-GTP: r = 0.496 and P = 0.016].	8-ohdg	25-31	inactive glutathione hydrolase 2	Homo sapiens	177-186
26604653-10	2015	The reduction of urinary 8-OHdG was significantly correlated with decreased levels of both ALT and gamma-GTP [ 8-OHdG and  ALT: Spearman r (r) 0.514 and P = 0.012,  8-OHdG and  gamma-GTP: r = 0.496 and P = 0.016].	8-ohdg	111-117	inactive glutathione hydrolase 2	Homo sapiens	99-108
26604653-10	2015	The reduction of urinary 8-OHdG was significantly correlated with decreased levels of both ALT and gamma-GTP [ 8-OHdG and  ALT: Spearman r (r) 0.514 and P = 0.012,  8-OHdG and  gamma-GTP: r = 0.496 and P = 0.016].	8-ohdg	111-117	inactive glutathione hydrolase 2	Homo sapiens	177-186
26604653-10	2015	The reduction of urinary 8-OHdG was significantly correlated with decreased levels of both ALT and gamma-GTP [ 8-OHdG and  ALT: Spearman r (r) 0.514 and P = 0.012,  8-OHdG and  gamma-GTP: r = 0.496 and P = 0.016].	8-ohdg	111-117	inactive glutathione hydrolase 2	Homo sapiens	99-108
26604653-10	2015	The reduction of urinary 8-OHdG was significantly correlated with decreased levels of both ALT and gamma-GTP [ 8-OHdG and  ALT: Spearman r (r) 0.514 and P = 0.012,  8-OHdG and  gamma-GTP: r = 0.496 and P = 0.016].	8-ohdg	111-117	inactive glutathione hydrolase 2	Homo sapiens	177-186
26556340-9	2015	We found that sestrin2 siRNA further augmented the formation of 8-OHdG induced by TGI with reperfusion for 4 h. Consistently, sestrin2 siRNA also enhanced apoptosis induced by TGI with reperfusion for 48 h based on the analysis of DNA fragmentation by agarose gel electrophoresis, DNA fragmentation sandwich ELISA, and the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay.	8-ohdg	64-70	sestrin 2	Homo sapiens	14-22
26438356-3	2015	The main oxidative lesion, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG), which is a pre-mutagenic lesion, can be detected by the comet assay coupled with the hOGG1 DNA repair enzyme.	8-ohdg	27-62	8-oxoguanine DNA glycosylase	Homo sapiens	159-164
26438356-3	2015	The main oxidative lesion, 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG), which is a pre-mutagenic lesion, can be detected by the comet assay coupled with the hOGG1 DNA repair enzyme.	8-ohdg	64-71	8-oxoguanine DNA glycosylase	Homo sapiens	159-164
26438356-11	2015	As the level of hOGG1 sensitive sites was increased in Cd and BaP exposed mussels, it seems that these chemicals induce 8-oxo-dG.	8-ohdg	120-128	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
26577825-5	2015	Probiotic soy milk significantly decreased promoter methylation in proximal and distal MLH1 promoter region (P &lt; 0.01 and P &lt; 0.0001, respectively) compared with the baseline values, while plasma concentration of 8-hydroxy-2"-deoxyguanosine (8-OHdG) decreased significantly compared with soy milk (P &lt; 0.05).	8-ohdg	248-254	mutL homolog 1	Homo sapiens	87-91
26452228-1	2015	Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant defense mechanism has not been locally investigated in the brain.	8-ohdg	100-126	klotho	Mus musculus	0-6
26362204-10	2015	The intensity of immunostaining for iNOS/nitrotyrosine correlated with 8-OHdG expression in cardiomyocyte nuclei.	8-ohdg	71-77	nitric oxide synthase 2	Homo sapiens	36-40
26338705-4	2015	POL beta incorporated rAMP and rCMP opposite 7,8-dihydro-8-oxoguanine (8-oxodG) and extended both mispairs.	8-ohdg	71-78	DNA polymerase beta	Homo sapiens	0-8
26338705-8	2015	In particular, MUTYH activity on 8-oxodG:rA mispairs is fully inhibited, although its binding capacity is retained.	8-ohdg	33-40	mutY DNA glycosylase	Homo sapiens	15-20
25710927-6	2015	Moreover, an inverse correlation was found between 8-oxodGuo in kidney DNA and circulating Adp levels in normoglycemic and diabetic rats.	8-ohdg	51-60	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	91-94
26224570-7	2015	Finally, using an in vivo murine model we confirmed the major role of TWEAK in oxidative stress, as genetic silencing of Tnfsf12 in an ApoE(-/-) background reduces the number of DHE and 8-hydroxydeoxyguanosine-positive macrophages by 50%.	8-ohdg	186-209	tumor necrosis factor (ligand) superfamily, member 12	Mus musculus	121-128
26224570-7	2015	Finally, using an in vivo murine model we confirmed the major role of TWEAK in oxidative stress, as genetic silencing of Tnfsf12 in an ApoE(-/-) background reduces the number of DHE and 8-hydroxydeoxyguanosine-positive macrophages by 50%.	8-ohdg	186-209	apolipoprotein E	Mus musculus	135-139
26412311-7	2015	Renal superoxide, 8-hydroxy deoxyguanosine, nitrotyrosine and the plasma Cys34-cysteinylated albumin were clearly suppressed by the HSA-Trx treatment.	8-ohdg	18-42	thioredoxin 1	Mus musculus	136-139
26234752-4	2015	Specifically, fertilization initiates post-translational modification to BER enzymes such as OGG1 and XRCC1, causing nuclear localisation and accelerated 8OHdG excision.	8-ohdg	154-159	8-oxoguanine DNA-glycosylase 1	Mus musculus	93-97
26234752-4	2015	Specifically, fertilization initiates post-translational modification to BER enzymes such as OGG1 and XRCC1, causing nuclear localisation and accelerated 8OHdG excision.	8-ohdg	154-159	X-ray repair complementing defective repair in Chinese hamster cells 1	Mus musculus	102-107
26234752-6	2015	The major limitation of the characterised 8OHdG repair system is the relatively low level of OGG1 expression in the oocyte, in contrast to the male germ line where it is the only constituent of the BER pathway.	8-ohdg	42-47	8-oxoguanine DNA-glycosylase 1	Mus musculus	93-97
26464256-6	2015	Correlation analysis showed positive correlations between 8-OHdG and hOGG1 levels (r=0.413; P&lt;0.01).	8-ohdg	58-64	8-oxoguanine DNA glycosylase	Homo sapiens	69-74
26315598-0	2015	Transcriptional mutagenesis by 8-oxodG in alpha-synuclein aggregation and the pathogenesis of Parkinson"s disease.	8-ohdg	31-38	synuclein alpha	Homo sapiens	42-57
25269426-10	2015	Sperm concentration was significantly lower but fraction of abnormal spermatozoa, and levels of 8-hydroxy-2-deoxyguanosine were significantly higher in leptin-treated rats on day 1 of recovery.	8-ohdg	96-122	leptin	Rattus norvegicus	152-158
26151194-9	2015	8-OHdG immunoreactivity was measured in the motor cortex, the magnocellular red nucleus (RMC) and the accessory oculomotor nucleus (MA3).	8-ohdg	0-6	tubulin, alpha 3A	Mus musculus	132-135
25947374-0	2015	Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2"-deoxyguanosine.	8-ohdg	96-131	DNA polymerase eta	Homo sapiens	45-63
26245656-10	2015	The results showed shorter 5- and 10-year survival in patients with 8-oxodG positive tumour cells (5-year survival, n=138, Mantel-Cox, chi-square 4.116, degree of freedom (df)=1, p&lt;0.05; 10-year survival, n=134, Mantel-Cox, chi-square 4.374, df=1, p&lt;0.05).	8-ohdg	68-75	cytochrome c oxidase subunit 8A	Homo sapiens	130-133
26245656-10	2015	The results showed shorter 5- and 10-year survival in patients with 8-oxodG positive tumour cells (5-year survival, n=138, Mantel-Cox, chi-square 4.116, degree of freedom (df)=1, p&lt;0.05; 10-year survival, n=134, Mantel-Cox, chi-square 4.374, df=1, p&lt;0.05).	8-ohdg	68-75	cytochrome c oxidase subunit 8A	Homo sapiens	222-225
25159108-9	2015	Pretreatment of MCF-7 and MCF-10F cells with and inhibitor of catechol-O-methyltransferase (COMT) followed by treatment with E2 or 4-OH E2 caused increased oxidative DNA damage (8-oxo-dG) and depurinating DNA adducts showing the importance of E2-catechol O-methylation by COMT as a protective pathway.	8-ohdg	178-186	catechol-O-methyltransferase	Homo sapiens	62-90
25159108-9	2015	Pretreatment of MCF-7 and MCF-10F cells with and inhibitor of catechol-O-methyltransferase (COMT) followed by treatment with E2 or 4-OH E2 caused increased oxidative DNA damage (8-oxo-dG) and depurinating DNA adducts showing the importance of E2-catechol O-methylation by COMT as a protective pathway.	8-ohdg	178-186	catechol-O-methyltransferase	Homo sapiens	92-96
26079740-10	2015	Anti-HMGB1 IgY reduced the number of 8-hydroxy-deoxyguanosine (8-OHdG)-positive cells induced by intravitreal NMDA.	8-ohdg	37-61	high mobility group box 1	Rattus norvegicus	5-10
26079740-10	2015	Anti-HMGB1 IgY reduced the number of 8-hydroxy-deoxyguanosine (8-OHdG)-positive cells induced by intravitreal NMDA.	8-ohdg	63-69	high mobility group box 1	Rattus norvegicus	5-10
25947374-1	2015	Like the other Y-family DNA polymerases, human DNA polymerase eta (hpol eta) has relatively low fidelity and is able to tolerate damage during DNA synthesis, including 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG), one of the most abundant DNA lesions in the genome.	8-ohdg	168-203	DNA polymerase eta	Homo sapiens	47-65
25947374-1	2015	Like the other Y-family DNA polymerases, human DNA polymerase eta (hpol eta) has relatively low fidelity and is able to tolerate damage during DNA synthesis, including 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG), one of the most abundant DNA lesions in the genome.	8-ohdg	168-203	endothelin receptor type A	Homo sapiens	62-65
25947374-1	2015	Like the other Y-family DNA polymerases, human DNA polymerase eta (hpol eta) has relatively low fidelity and is able to tolerate damage during DNA synthesis, including 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG), one of the most abundant DNA lesions in the genome.	8-ohdg	205-211	DNA polymerase eta	Homo sapiens	47-65
25947374-1	2015	Like the other Y-family DNA polymerases, human DNA polymerase eta (hpol eta) has relatively low fidelity and is able to tolerate damage during DNA synthesis, including 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG), one of the most abundant DNA lesions in the genome.	8-ohdg	205-211	endothelin receptor type A	Homo sapiens	62-65
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	8-ohdg	247-253	X-ray repair cross complementing 1	Homo sapiens	22-27
28962422-8	2015	Results indicated the significantly increasing expression of ROS and 8-OHdG which accompanied with STAT3 hypomethylation in 1,4-BQ-treated AHH-1 cells.	8-ohdg	69-75	signal transducer and activator of transcription 3	Homo sapiens	99-104
25900576-3	2015	We have developed 8-halogenated-7-deaza-2"-deoxyguanosine derivatives that resemble 8-oxo-dG in that they adopt the syn conformation.	8-ohdg	84-92	synemin	Homo sapiens	116-119
25900576-7	2015	The benefits of the high binding affinities and low reactivities of 8-oxo-dG analogues with hOGG1 have been successfully applied to the competitive inhibition of the excision of 8-oxoguanine from duplex DNA by hOGG1.	8-ohdg	68-76	8-oxoguanine DNA glycosylase	Homo sapiens	92-97
25900576-7	2015	The benefits of the high binding affinities and low reactivities of 8-oxo-dG analogues with hOGG1 have been successfully applied to the competitive inhibition of the excision of 8-oxoguanine from duplex DNA by hOGG1.	8-ohdg	68-76	8-oxoguanine DNA glycosylase	Homo sapiens	210-215
25701431-7	2015	Nox1 deficiency significantly reduced the levels of renal thiobarbituric acid-reacting substances and 8-hydroxydeoxyguanosine, membranous translocation of PKCalpha/beta, activity of PKC, and phosphorylation of p38 mitogen-activated protein kinase in the diabetic kidney.	8-ohdg	102-125	NADPH oxidase 1	Mus musculus	0-4
25724107-5	2015	Simultaneously, the level of 8-oxo-deoxyguanosine, an indicator of oxidative damage, was markedly lowered in SFN-treated diabetic rats, together with a significant reduction in activity of the GSK-3beta/Fyn axis and an evident activation of Nrf2 signaling.	8-ohdg	29-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	241-245
25938407-1	2015	The aim of this study was to examine the associations between the combined effects of urinary 8-Hydroxydeoxyguanine (8-OHdG) level and polymorphisms of XRCC1 Arg194Trp and XRCC1 Arg399Gln on the risk of urothelial carcinoma (UC).	8-ohdg	117-123	X-ray repair cross complementing 1	Homo sapiens	152-157
25938407-1	2015	The aim of this study was to examine the associations between the combined effects of urinary 8-Hydroxydeoxyguanine (8-OHdG) level and polymorphisms of XRCC1 Arg194Trp and XRCC1 Arg399Gln on the risk of urothelial carcinoma (UC).	8-ohdg	117-123	X-ray repair cross complementing 1	Homo sapiens	172-177
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	8-ohdg	247-253	X-ray repair cross complementing 1	Homo sapiens	85-90
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	8-ohdg	110-116	X-ray repair cross complementing 1	Homo sapiens	22-27
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	8-ohdg	110-116	X-ray repair cross complementing 1	Homo sapiens	85-90
26023673-7	2015	However, immunoreactivity of PLCzeta showed a significant negative relationship with 8-OHdG immunoreactivity (r=-0.404, P=0.009).	8-ohdg	85-91	phospholipase C zeta 1	Homo sapiens	29-36
25791474-5	2015	The PINK1 siRNA also aggravated the TGI-induced oxidative DNA damage with an increased 8-hydroxy-deoxyguanosine (8-OHdG) content in hippocampal CA1 subfield.	8-ohdg	87-111	PTEN induced kinase 1	Homo sapiens	4-9
25791474-5	2015	The PINK1 siRNA also aggravated the TGI-induced oxidative DNA damage with an increased 8-hydroxy-deoxyguanosine (8-OHdG) content in hippocampal CA1 subfield.	8-ohdg	87-111	carbonic anhydrase 1	Homo sapiens	144-147
25791474-5	2015	The PINK1 siRNA also aggravated the TGI-induced oxidative DNA damage with an increased 8-hydroxy-deoxyguanosine (8-OHdG) content in hippocampal CA1 subfield.	8-ohdg	113-119	PTEN induced kinase 1	Homo sapiens	4-9
25791474-5	2015	The PINK1 siRNA also aggravated the TGI-induced oxidative DNA damage with an increased 8-hydroxy-deoxyguanosine (8-OHdG) content in hippocampal CA1 subfield.	8-ohdg	113-119	carbonic anhydrase 1	Homo sapiens	144-147
25612631-7	2015	CONCLUSIONS: In this study, serum MDA and 8-OHdG were found to be highest in the HLp group.	8-ohdg	42-48	HLP	Homo sapiens	81-84
25612631-8	2015	The increased levels of MDA and 8-OHdG in HLp patients may be a result of a harmful oxidative status in association with hyperlipidemia and periodontitis.	8-ohdg	32-38	HLP	Homo sapiens	42-45
25879528-7	2015	RESULTS: Nuclear 8-OHdG associated with cytoplasmic Keap1 expression (p = 0.031) and was overexpressed in patients with smaller tumors (p = 0.016) and in tumors without lymph node involvement (p = 0.051).	8-ohdg	17-23	kelch like ECH associated protein 1	Homo sapiens	52-57
25105541-5	2015	Furthermore, AGE-aptamer significantly suppressed the increase in adipocyte size and prevented the elevation in AGEs, RAGE, and an oxidative stress marker, 8-hydroxydeoxyguanosine (8-OHdG), levels in adipose tissues of fructose-fed rats at 14-week-old, while it restored the decrease in adiponectin mRNA levels.	8-ohdg	156-179	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	287-298
25105541-5	2015	Furthermore, AGE-aptamer significantly suppressed the increase in adipocyte size and prevented the elevation in AGEs, RAGE, and an oxidative stress marker, 8-hydroxydeoxyguanosine (8-OHdG), levels in adipose tissues of fructose-fed rats at 14-week-old, while it restored the decrease in adiponectin mRNA levels.	8-ohdg	181-187	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	287-298
25542138-3	2015	We found higher levels of 8-OHdG and PC in the NTD group than in the control group; however, we did not observe a statistically significant difference in 8-iso-PGF2alpha levels between the NTD and the control groups.	8-ohdg	26-32	fuzzy planar cell polarity protein	Homo sapiens	47-50
25741586-0	2015	Unlike catalyzing error-free bypass of 8-oxodGuo, DNA polymerase lambda is responsible for a significant part of Fapy dG-induced G   T mutations in human cells.	8-ohdg	39-48	DNA polymerase lambda	Homo sapiens	50-71
25741997-10	2015	Furthermore, we found a significant interaction effect between PON1 rs662 and smoking status on urinary 8-OHdG levels in lung cancer patients.	8-ohdg	104-110	paraoxonase 1	Homo sapiens	63-67
25671815-0	2015	The role of hOGG1 C1245G polymorphism in the susceptibility to lupus nephritis and modulation of the plasma 8-OHdG in patients with systemic lupus erythematosus.	8-ohdg	108-114	8-oxoguanine DNA glycosylase	Homo sapiens	12-17
24584621-6	2015	The HD modality (standard beta = 0.57, p &lt; 0.001) and dialysis vintage (standard beta = 0.12, p = 0.02) were independent predictors of serum 8-OHdG in a multivariable linear regression model including age, sex, body mass index, dialysis modality (HD or PD), preceding time on dialysis (dialysis vintage), PEW, comorbidity score, IL-6, and use of angiotensin converting-enzyme inhibitors or angiotensin II receptor blockers or statins.	8-ohdg	144-150	interleukin 6	Homo sapiens	332-336
25671815-1	2015	We investigated whether the C1245G polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) gene confers the susceptibility to systemic lupus erythematosus (SLE) occurrence of lupus nephritis and affects the plasma level of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in patients with SLE.	8-ohdg	224-251	8-oxoguanine DNA glycosylase	Homo sapiens	85-90
25671815-1	2015	We investigated whether the C1245G polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) gene confers the susceptibility to systemic lupus erythematosus (SLE) occurrence of lupus nephritis and affects the plasma level of 8-hydroxy-2"-deoxyguanosine (8-OHdG) in patients with SLE.	8-ohdg	253-259	8-oxoguanine DNA glycosylase	Homo sapiens	85-90
25671815-8	2015	We conclude that the C1245G polymorphism of hOGG1 may be one of the factors that confer the susceptibility to lupus nephritis and modulate the plasma level of 8-OHdG in patients with SLE.	8-ohdg	159-165	8-oxoguanine DNA glycosylase	Homo sapiens	44-49
25534136-3	2015	One driver of oxidative stress that can induce 8-oxodG is inflammation, which can be initiated by the cytokine tumor necrosis factor alpha (TNF-alpha).	8-ohdg	47-54	tumor necrosis factor	Homo sapiens	111-138
25483558-9	2015	We also found that levels or immunoreactivities of superoxide anion, 8-hydroxy-2"-deoxyguanosine and 4-hydroxy-2-nonenal were significantly decreased in the CA1 of both IPC+sham-operated- and IPC+ischemia-operated groups.	8-ohdg	69-96	carbonic anhydrase 1	Homo sapiens	157-160
25534136-3	2015	One driver of oxidative stress that can induce 8-oxodG is inflammation, which can be initiated by the cytokine tumor necrosis factor alpha (TNF-alpha).	8-ohdg	47-54	tumor necrosis factor	Homo sapiens	140-149
25534136-5	2015	8-oxodG is excised by 8-oxoguanine glycosylase 1 (OGG1).	8-ohdg	0-7	8-oxoguanine DNA glycosylase	Homo sapiens	22-48
25534136-5	2015	8-oxodG is excised by 8-oxoguanine glycosylase 1 (OGG1).	8-ohdg	0-7	8-oxoguanine DNA glycosylase	Homo sapiens	50-54
25534136-14	2015	Physiologically relevant levels of TNF-alpha simultaneously induce 8-oxodG and inactivate S326C-OGG1.	8-ohdg	67-74	tumor necrosis factor	Homo sapiens	35-44
25922551-5	2015	The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-alpha, 8-hydroxy-2"-deoxyguanosine, and nitrite/nitrate.	8-ohdg	231-258	pentraxin 3	Homo sapiens	39-43
26308756-11	2015	RESULTS: The CCl4 induced (1) significant hepatic-function damage; (2) elevated levels of the measures of the liver fibrosis index, TGF-beta1, inflammatory cytokines, MDA, and 8-OHdG; (3) a reduction in the activities of T-SOD and T-AOC; and (4) no effect on the level of expression of hepatic Ang 2.	8-ohdg	176-182	C-C motif chemokine ligand 4	Rattus norvegicus	13-17
25479043-12	2015	Pretreatment with p38 inhibitor (SB203580) abolished the protective effect of COS on retinal oxidative damage, as indicated by increased retinal 8-OHdG stains, and significantly increased the expression of inflammatory mediators (TNF-alpha, MCP-1, iNOS, ICAM-1) in I/R-injured rats.	8-ohdg	145-151	mitogen activated protein kinase 14	Rattus norvegicus	18-21
26161003-8	2015	CONCLUSION: We discovered an important relationship between hsCRP, 8-oxodG, and BDNF in women at hsCRP levels &gt;3 mg/L.	8-ohdg	67-74	brain derived neurotrophic factor	Homo sapiens	80-84
26160410-0	2015	Tumor Necrosis Factor-Alpha and 8-Hydroxy-2"-Deoxyguanosine are Associated with Elevated Urinary Angiopoietin-2 Level in Type 2 Diabetic Patients with Albuminuria.	8-ohdg	32-59	angiopoietin 2	Homo sapiens	97-111
26160410-6	2015	RESULTS: Serum and urine TNF-alpha, IL-18 and 8-OHdG levels increased significantly with the degree of albuminuria, and were positively correlated with increased Ang-2.	8-ohdg	46-52	angiopoietin 2	Homo sapiens	162-167
26160410-8	2015	Multivariable linear regression analysis revealed that serum Ang-2 level was independently associated with serum levels of TNF-alpha (P&lt;0.001), 8-OHdG (P=0.001), and IL-18 (P=0.003).	8-ohdg	147-153	angiopoietin 2	Homo sapiens	61-66
26160410-9	2015	Urinary Ang-2 level was independently associated with urinary TNF-alpha (P&lt;0.001) and 8-OHdG (P=0.004) levels.	8-ohdg	89-95	angiopoietin 2	Homo sapiens	8-13
26160410-10	2015	CONCLUSION: TNF-alpha and 8-OHdG are associated with elevated urinary Angiopoietin-2 levels in type 2 diabetic patients with albuminuria.	8-ohdg	26-32	angiopoietin 2	Homo sapiens	70-84
25876967-4	2015	RESULTS: In the experiments to detect the effect of TGF-beta1 on pulmonary fibroblasts, compared with control, TGF-beta1 significantly stimulated pulmonary fibroblast proliferation and increased collagen I and III protein, p-JNK and 8-OHdG levels.	8-ohdg	233-239	transforming growth factor beta 1	Homo sapiens	52-61
25876967-4	2015	RESULTS: In the experiments to detect the effect of TGF-beta1 on pulmonary fibroblasts, compared with control, TGF-beta1 significantly stimulated pulmonary fibroblast proliferation and increased collagen I and III protein, p-JNK and 8-OHdG levels.	8-ohdg	233-239	transforming growth factor beta 1	Homo sapiens	111-120
26676080-5	2015	RESULTS: Status of markers of oxidative stress (malondialdehyde, protein carbonyl and 8-hydroxy-2-deoxy guanosine) showed a significant increase with depleted levels of total antioxidant capacity in neonatal RDS when compared to healthy newborns.	8-ohdg	86-113	peripherin 2	Homo sapiens	208-211
25526641-10	2014	Aforementioned result may suggest that the diseased cells with polymorphic OGG1 recruit more PARP protein, which is necessary to remove 8-oxodGuo.	8-ohdg	136-145	8-oxoguanine DNA glycosylase	Homo sapiens	75-79
25526641-10	2014	Aforementioned result may suggest that the diseased cells with polymorphic OGG1 recruit more PARP protein, which is necessary to remove 8-oxodGuo.	8-ohdg	136-145	poly(ADP-ribose) polymerase 1	Homo sapiens	93-97
25526641-11	2014	Thus, patients with decreased activity of OGG1/polymorphism of the OGG1 gene and higher 8-oxodGuo level may be more susceptible to treatment with PARP-1 inhibitors.	8-ohdg	88-97	8-oxoguanine DNA glycosylase	Homo sapiens	42-46
25526641-11	2014	Thus, patients with decreased activity of OGG1/polymorphism of the OGG1 gene and higher 8-oxodGuo level may be more susceptible to treatment with PARP-1 inhibitors.	8-ohdg	88-97	8-oxoguanine DNA glycosylase	Homo sapiens	67-71
25526641-11	2014	Thus, patients with decreased activity of OGG1/polymorphism of the OGG1 gene and higher 8-oxodGuo level may be more susceptible to treatment with PARP-1 inhibitors.	8-ohdg	88-97	poly(ADP-ribose) polymerase 1	Homo sapiens	146-152
25423485-5	2014	The increase in 8-oxodG and 5mC content was associated with a markedly reduced expression of the 8-oxoguanine DNA-glycosylase 1 (Ogg1) and increased expression of de novo DNA methyltransferases 3a and 3b (Dnmt3a and Dnmt3b).	8-ohdg	16-23	8-oxoguanine DNA-glycosylase 1	Mus musculus	97-127
25423485-5	2014	The increase in 8-oxodG and 5mC content was associated with a markedly reduced expression of the 8-oxoguanine DNA-glycosylase 1 (Ogg1) and increased expression of de novo DNA methyltransferases 3a and 3b (Dnmt3a and Dnmt3b).	8-ohdg	16-23	8-oxoguanine DNA-glycosylase 1	Mus musculus	129-133
25423485-5	2014	The increase in 8-oxodG and 5mC content was associated with a markedly reduced expression of the 8-oxoguanine DNA-glycosylase 1 (Ogg1) and increased expression of de novo DNA methyltransferases 3a and 3b (Dnmt3a and Dnmt3b).	8-ohdg	16-23	DNA methyltransferase 3A	Mus musculus	171-203
25423485-5	2014	The increase in 8-oxodG and 5mC content was associated with a markedly reduced expression of the 8-oxoguanine DNA-glycosylase 1 (Ogg1) and increased expression of de novo DNA methyltransferases 3a and 3b (Dnmt3a and Dnmt3b).	8-ohdg	16-23	DNA methyltransferase 3A	Mus musculus	205-211
25423485-5	2014	The increase in 8-oxodG and 5mC content was associated with a markedly reduced expression of the 8-oxoguanine DNA-glycosylase 1 (Ogg1) and increased expression of de novo DNA methyltransferases 3a and 3b (Dnmt3a and Dnmt3b).	8-ohdg	16-23	DNA methyltransferase 3B	Mus musculus	216-222
25397406-7	2014	Exogenous NGF supplementation and endogenous NGF overexpression effectively protected hepatocytes against TGF-beta1- and oxidative stress-induced cell death in vitro, along with reduced formation of oxidative adducted proteins modified by 4-HNE and 8-OHdG.	8-ohdg	249-255	nerve growth factor	Rattus norvegicus	10-13
25397406-7	2014	Exogenous NGF supplementation and endogenous NGF overexpression effectively protected hepatocytes against TGF-beta1- and oxidative stress-induced cell death in vitro, along with reduced formation of oxidative adducted proteins modified by 4-HNE and 8-OHdG.	8-ohdg	249-255	nerve growth factor	Rattus norvegicus	45-48
24819310-11	2014	Increased levels in 8-hydroxy-2-deoxy guanosine and histone acetyltransferase activities, decreased histone deacetylase activities, and DNA breakage detected in nuclear extracts showed that CCl4 intoxication induces oxidative stress and apoptosis in rat liver.	8-ohdg	20-47	C-C motif chemokine ligand 4	Rattus norvegicus	190-194
25414704-8	2014	The HSA-Trx treatment significantly decreased the level of 8-hydroxy-2"-deoxyguanosine and 3-nitrotyrosine, but failed to inhibit inducible nitric oxide synthase expression, in the lungs of the virus-infected mice.	8-ohdg	59-86	thioredoxin 1	Mus musculus	8-11
25127756-8	2014	Following the treatment with H2O2, the 8-oxo-dG levels in the DNA of hOGG1 gene knockdown cells were 3.1-fold higher than those in untreated HFL cells, and 1.67-fold higher than those in H2O2-treated wild-type cells.	8-ohdg	39-47	8-oxoguanine DNA glycosylase	Homo sapiens	69-74
25096646-8	2014	Single and partial regression analyses indicated a negative association between urinary 8-oxodG levels with SBP, DBP and PP only in African men.	8-ohdg	88-95	selenium binding protein 1	Homo sapiens	108-111
24722438-9	2014	Mafb transgenic glomeruli also overexpressed glutathione peroxidase, an antioxidative stress enzyme, and levels of the oxidative stress marker 8-hydroxydeoxyguanosine decreased in the urine of diabetic Mafb transgenic mice.	8-ohdg	143-166	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	Mus musculus	0-4
24722438-9	2014	Mafb transgenic glomeruli also overexpressed glutathione peroxidase, an antioxidative stress enzyme, and levels of the oxidative stress marker 8-hydroxydeoxyguanosine decreased in the urine of diabetic Mafb transgenic mice.	8-ohdg	143-166	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	Mus musculus	202-206
25294835-1	2014	Human DNA polymerase kappa (hpol kappa) is the only Y-family member to preferentially insert dAMP opposite 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxo-dG) during translesion DNA synthesis.	8-ohdg	107-142	DNA polymerase kappa	Homo sapiens	6-26
25294835-1	2014	Human DNA polymerase kappa (hpol kappa) is the only Y-family member to preferentially insert dAMP opposite 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxo-dG) during translesion DNA synthesis.	8-ohdg	144-152	DNA polymerase kappa	Homo sapiens	6-26
25294835-2	2014	We have studied the mechanism of action by which hpol kappa activity is modulated by the Werner syndrome protein (WRN), a RecQ helicase known to influence repair of 8-oxo-dG.	8-ohdg	165-173	WRN RecQ like helicase	Homo sapiens	89-112
25294835-2	2014	We have studied the mechanism of action by which hpol kappa activity is modulated by the Werner syndrome protein (WRN), a RecQ helicase known to influence repair of 8-oxo-dG.	8-ohdg	165-173	WRN RecQ like helicase	Homo sapiens	114-117
25294835-3	2014	Here we show that WRN stimulates the 8-oxo-dG bypass activity of hpol kappa in vitro by enhancing the correct base insertion opposite the lesion, as well as extension from dC:8-oxo-dG base pairs.	8-ohdg	37-45	WRN RecQ like helicase	Homo sapiens	18-21
25294835-3	2014	Here we show that WRN stimulates the 8-oxo-dG bypass activity of hpol kappa in vitro by enhancing the correct base insertion opposite the lesion, as well as extension from dC:8-oxo-dG base pairs.	8-ohdg	175-183	WRN RecQ like helicase	Homo sapiens	18-21
25294835-4	2014	Steady-state kinetic analysis reveals that WRN improves hpol kappa-catalyzed dCMP insertion opposite 8-oxo-dG ~10-fold and extension from dC:8-oxo-dG by 2.4-fold.	8-ohdg	101-109	WRN RecQ like helicase	Homo sapiens	43-46
25294835-4	2014	Steady-state kinetic analysis reveals that WRN improves hpol kappa-catalyzed dCMP insertion opposite 8-oxo-dG ~10-fold and extension from dC:8-oxo-dG by 2.4-fold.	8-ohdg	141-149	WRN RecQ like helicase	Homo sapiens	43-46
25294835-7	2014	Thus, WRN limits the error-prone bypass of 8-oxo-dG by hpol kappa, which could influence the sensitivity to oxidative damage that has previously been observed for Werner"s syndrome cells.	8-ohdg	43-51	WRN RecQ like helicase	Homo sapiens	6-9
24664859-8	2014	The presence of cagA gene and high expression of 8-OHdG was highly correlated with severe gastric inflammation and gastric cancer particularly, in cases with infiltration of chronic inflammatory cells (36.8 % cagA + ve, 18 %), neutrophilic activity (47.2 %, 25.5 %), intestinal metaplasia (77.7 %, 35.7 %) and intestinal type gastric cancer (95 %, 95.4 %) (p &lt;= 0.01).	8-ohdg	49-55	S100 calcium binding protein A8	Homo sapiens	209-213
25255211-0	2014	Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2"-deoxyguanosine.	8-ohdg	129-164	primase and DNA directed polymerase	Homo sapiens	26-33
25255211-7	2014	PrimPol inserts dCMP opposite 8-oxo-dG with 2- (Mn2+) to 6-fold (Mg2+) greater efficiency than dAMP misinsertion.	8-ohdg	30-38	primase and DNA directed polymerase	Homo sapiens	0-7
25255211-8	2014	PrimPol-catalyzed dCMP insertion opposite 8-oxo-dG proceeds at ~25% efficiency relative to unmodified template dG, and PrimPol readily extends from dC:8-oxo-dG base pairs (bps) with ~2-fold greater efficiency than dA:8-oxo-dG bps.	8-ohdg	42-50	primase and DNA directed polymerase	Homo sapiens	0-7
25255211-8	2014	PrimPol-catalyzed dCMP insertion opposite 8-oxo-dG proceeds at ~25% efficiency relative to unmodified template dG, and PrimPol readily extends from dC:8-oxo-dG base pairs (bps) with ~2-fold greater efficiency than dA:8-oxo-dG bps.	8-ohdg	151-159	primase and DNA directed polymerase	Homo sapiens	0-7
25255211-8	2014	PrimPol-catalyzed dCMP insertion opposite 8-oxo-dG proceeds at ~25% efficiency relative to unmodified template dG, and PrimPol readily extends from dC:8-oxo-dG base pairs (bps) with ~2-fold greater efficiency than dA:8-oxo-dG bps.	8-ohdg	151-159	primase and DNA directed polymerase	Homo sapiens	119-126
25255211-8	2014	PrimPol-catalyzed dCMP insertion opposite 8-oxo-dG proceeds at ~25% efficiency relative to unmodified template dG, and PrimPol readily extends from dC:8-oxo-dG base pairs (bps) with ~2-fold greater efficiency than dA:8-oxo-dG bps.	8-ohdg	151-159	primase and DNA directed polymerase	Homo sapiens	0-7
25255211-8	2014	PrimPol-catalyzed dCMP insertion opposite 8-oxo-dG proceeds at ~25% efficiency relative to unmodified template dG, and PrimPol readily extends from dC:8-oxo-dG base pairs (bps) with ~2-fold greater efficiency than dA:8-oxo-dG bps.	8-ohdg	151-159	primase and DNA directed polymerase	Homo sapiens	119-126
25255211-10	2014	In summary, PrimPol exhibits the fidelity typical of other TLS pols, is rather unusual in the degree of activation afforded by Mn2+, and accurately bypasses 8-oxo-dG, a DNA lesion of special relevance to mitochondrial DNA replication and transcription.	8-ohdg	157-165	primase and DNA directed polymerase	Homo sapiens	12-19
25127756-9	2014	The 8-oxo-dG levels in hMTH1 gene knockdown cells were 2.3-fold higher than those in untreated human embryonic pulmonary fibroblast cells, but did not differ significantly from those in H2O2-treated wild-type cells.	8-ohdg	4-12	nudix hydrolase 1	Homo sapiens	23-28
25017967-4	2014	Ischemia/reperfusion induced a significant increase in NADPH oxidase 4 (NOX-4) expression at the tubular level, an upregulation of NOX-2 expression in infiltrating monocytes and myeloid dendritic cells, and 8-oxo-7,8-dihydro-2"-deoxyguanosine synthesis along with a marked upregulation of NADPH-dependent superoxide generation.	8-ohdg	207-242	cytochrome b-245 heavy chain	Sus scrofa	131-136
24906089-6	2014	8-OHdG, PC, and MDA were negatively correlated with expression of TLR-9 and TAS levels.	8-ohdg	0-6	toll like receptor 9	Homo sapiens	66-71
24846010-6	2014	In DM1, stage VII-IX tubules showed more cytoplasmic expression of 8-oxo-7, 8-dihydro-2"-deoxyguanosine in all germ cell types and the Sertoli cells than did the other stage tubules, which suggested mitochondrial DNA damage.	8-ohdg	67-103	immunoglobulin heavy diversity 1-7	Homo sapiens	3-6
24976129-4	2014	Synergistic exposure of CEES and LPS provoked significant increase in phosphorylation of MAPKs, Akt, tuberin, that down regulate OGG1 expression and 8-OHdG accumulations.	8-ohdg	149-155	thymoma viral proto-oncogene 1	Mus musculus	96-99
24976129-4	2014	Synergistic exposure of CEES and LPS provoked significant increase in phosphorylation of MAPKs, Akt, tuberin, that down regulate OGG1 expression and 8-OHdG accumulations.	8-ohdg	149-155	TSC complex subunit 2	Mus musculus	101-108
24976129-7	2014	Collectively, our results indicate that exposure of CEES and LPS induces oxidative stress and the activation of tuberin, and 8-OHdG accumulation via upstream signaling pathways including Akt and ERK1/2MAPK pathway in macrophages but not the down regulation of OGG1.	8-ohdg	125-131	thymoma viral proto-oncogene 1	Mus musculus	187-190
25090023-9	2014	High ID3 protein expression correlated with a greater degree of malignancy and oxidative DNA damage marker 8-OHdG in blood vessels from human subjects.	8-ohdg	107-113	inhibitor of DNA binding 3, HLH protein	Homo sapiens	5-8
25182986-1	2014	OBJECTIVE: To study the excision repair capacity of human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) for 8-OH-dG and the oxidative DNA damage among workers exposed to nickel in stainless steel production environment.	8-ohdg	103-110	8-oxoguanine DNA glycosylase	Homo sapiens	92-97
25182986-5	2014	Pearson correlation was used to analyze the correlation between urinary 8-OH-dG level and hOGG1 mRNA level.	8-ohdg	72-79	8-oxoguanine DNA glycosylase	Homo sapiens	90-95
25182986-10	2014	Pearson correlation analysis showed that urinary 8-OH-dG level was positively correlated with hOGG1 mRNA level (r = 0.993) in different types of nickel-exposed workers, and the correlation was significant at alpha = 0.01 (P &lt; 0.05); urinary 8-OH-dG level also showed a positive correlation with hOGG1 mRNA level in nickel-exposed workers with different working years (r = 0.968), and the correlation was significant at alpha = 0.01 (P &lt; 0.05).	8-ohdg	49-56	8-oxoguanine DNA glycosylase	Homo sapiens	94-99
25182986-10	2014	Pearson correlation analysis showed that urinary 8-OH-dG level was positively correlated with hOGG1 mRNA level (r = 0.993) in different types of nickel-exposed workers, and the correlation was significant at alpha = 0.01 (P &lt; 0.05); urinary 8-OH-dG level also showed a positive correlation with hOGG1 mRNA level in nickel-exposed workers with different working years (r = 0.968), and the correlation was significant at alpha = 0.01 (P &lt; 0.05).	8-ohdg	49-56	8-oxoguanine DNA glycosylase	Homo sapiens	298-303
25182986-11	2014	CONCLUSION: Exposure to nickel increases oxidative DNA damage among steel workers, and hOGG1 shows active excision repair capacity for 8-OH-dG.	8-ohdg	135-142	8-oxoguanine DNA glycosylase	Homo sapiens	87-92
25036934-5	2014	Electrophoretic gel motility shift assay showed that two continuous CpG loci located five bases upstream of the TATA-box were, when methylated, a target of methyl CpG binding protein 2 (MeCP2) that was sequestered upon induction of 8-hydroxy-2-deoxyguanosine, a biomarker of oxidative damage to DNA.	8-ohdg	232-258	methyl CpG binding protein 2	Mus musculus	156-184
25036934-5	2014	Electrophoretic gel motility shift assay showed that two continuous CpG loci located five bases upstream of the TATA-box were, when methylated, a target of methyl CpG binding protein 2 (MeCP2) that was sequestered upon induction of 8-hydroxy-2-deoxyguanosine, a biomarker of oxidative damage to DNA.	8-ohdg	232-258	methyl CpG binding protein 2	Mus musculus	186-191
24972137-4	2014	The apoE-/- group exhibited increases in body weight and serum lipid levels in addition to high-density lipoprotein, and increases in 24-h urinary 8-hydroxy-2-deoxyguanosine and albuminuria excretion.	8-ohdg	147-173	apolipoprotein E	Mus musculus	4-8
24634198-0	2014	Determination of 8-hydroxy-2"- deoxyguanosine derivatized with 4-chloro-7- nitrobenzofurazan in urine by CE-LIF.	8-ohdg	17-45	LIF interleukin 6 family cytokine	Homo sapiens	108-111
24634198-4	2014	In this study, a simple and sensitive method was developed for the determination of 8-OHdG in urine by using CE-LIF and precapillary derivatization of 8-OHdG with 4-chloro-7-nitrobenzofurazan (NBD-Cl).	8-ohdg	84-90	LIF interleukin 6 family cytokine	Homo sapiens	112-115
24569162-1	2014	The MUTYH DNA glycosylase counteracts mutagenesis by removing adenine misincorporated opposite DNA 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG).	8-ohdg	99-134	mutY DNA glycosylase	Homo sapiens	4-9
24569162-1	2014	The MUTYH DNA glycosylase counteracts mutagenesis by removing adenine misincorporated opposite DNA 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG).	8-ohdg	136-143	mutY DNA glycosylase	Homo sapiens	4-9
24720662-10	2014	NGR1 prevented oxidative stress by suppressing NADPH oxidase- and mitochondrion-derived superoxide and inhibiting production of malondialdehyde, protein carbonyl, and 8-hydroxydeoxyguanosine in vivo and in vitro.	8-ohdg	167-190	reticulon 4 receptor	Rattus norvegicus	0-4
24759104-0	2014	Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2"-deoxyguanosine bypass by human DNA polymerase eta.	8-ohdg	38-73	DNA polymerase eta	Homo sapiens	90-108
24922645-9	2014	DNA damage in SOD3-overexpressing cells was confirmed by 8-OHdG elevation.	8-ohdg	57-63	superoxide dismutase 3	Homo sapiens	14-18
24712752-6	2014	CCl4-treated rats exhibited significant increases in the following parameters as compared to non-treated rats: fat droplets in the liver, liver injury (ALT, AST), and DNA damage (8-OHdG).	8-ohdg	179-185	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
24779885-2	2014	Replicative DNA polymerases poorly traverse this highly mutagenic lesion, suggesting that the replication fork may switch to a polymerase specialized for translesion DNA synthesis (TLS) to catalyze 8-oxodG bypass in vivo.	8-ohdg	198-205	FUS RNA binding protein	Homo sapiens	181-184
24733353-5	2014	The device was able to detect 8-OHdG concentrations in PBS as low as 2.07 ng mL(-1) by the colorimetric method and 3.11 ng mL(-1) by the electrochemical method.	8-ohdg	30-36	L1 cell adhesion molecule	Mus musculus	77-83
24733353-6	2014	Furthermore, the device was successfully utilized to detect 8-OHdG in urine with a detection limit of 5.76 ng mL(-1) (colorimetric method) and 8.85 ng mL(-1) (electrochemical method), respectively.	8-ohdg	60-66	L1 cell adhesion molecule	Mus musculus	110-116
24733353-6	2014	Furthermore, the device was successfully utilized to detect 8-OHdG in urine with a detection limit of 5.76 ng mL(-1) (colorimetric method) and 8.85 ng mL(-1) (electrochemical method), respectively.	8-ohdg	60-66	L1 cell adhesion molecule	Mus musculus	151-157
24779885-4	2014	Primer extension assays revealed that the times required for hPoleta, hRev1, hPolkappa, and hPoliota to bypass 50% of the 8-oxodG lesions encountered (t50(bypass)) were 0.58, 0.86, 108, and 670 s, respectively.	8-ohdg	122-129	DNA polymerase mu	Homo sapiens	92-100
23902537-3	2014	8-OHdG is excision-repaired by 8-OHdG DNA glycosylase (OGG1).	8-ohdg	0-6	8-oxoguanine DNA glycosylase	Homo sapiens	55-59
24779885-5	2014	Although hRev1 bypassed 8-oxodG efficiently, hRev1 failed to catalyze the extension step of TLS, and a second polymerase was required to extend the lesion bypass products.	8-ohdg	24-31	REV1 DNA directed polymerase	Homo sapiens	9-14
24779885-9	2014	The combination of hRev1 and hPolkappa was most accurate opposite 8-oxodG (92.3%), whereas hPolkappa alone was the least accurate (18.5%).	8-ohdg	66-73	REV1 DNA directed polymerase	Homo sapiens	19-24
24345202-4	2014	The increase in plasma 8-OHdG was correlated positively with the elevation of leucocyte expression of the genes encoding hOGG1 (P &lt; 0 05), anti-oxidant enzymes (P &lt; 0 05), several mitochondrial biogenesis-related proteins (P &lt; 0 05) and glycolytic enzymes (P &lt; 0 05) in lupus patients.	8-ohdg	23-29	8-oxoguanine DNA glycosylase	Homo sapiens	121-126
24345202-5	2014	The patients, whose leucocyte mtDNA harboured D310 heteroplasmy, exhibited a positive correlation between the mtDNA copy number and expression of ND1, ND6 and ATPase 6 (P &lt; 0 05) and a negative correlation between mtDNA copy number and systemic lupus erythematosus disease activity index (SLEDAI) (P &lt; 0 05), as well as plasma 8-OHdG (P &lt; 0 05).	8-ohdg	333-339	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	146-149
24797175-5	2014	In addition, decrease in tuberin expression resulted in a significant decrease in protein expression of OGG1 and increased in oxidative DNA damage, 8-oxodG in kidney tissues from patients with cancer or cancer+diabetes.	8-ohdg	148-155	TSC complex subunit 2	Homo sapiens	25-32
24644288-8	2014	Furthermore, the expression level of 8-hydroxydeoxyguanosine, an oxidative stress marker, was enhanced in the beta-cells of HFD-treated TRalpha-deficient mice.	8-ohdg	37-60	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	136-143
23676441-9	2014	Consistent with the antioxidative function of Nrf2, a DNA oxidative damage marker (8OHdG) dramatically increased in oesophageal epithelial cells of Nrf2(-/-) mice compared with those of wild-type mice.	8-ohdg	83-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
23676441-9	2014	Consistent with the antioxidative function of Nrf2, a DNA oxidative damage marker (8OHdG) dramatically increased in oesophageal epithelial cells of Nrf2(-/-) mice compared with those of wild-type mice.	8-ohdg	83-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-152
23902537-8	2014	An increase of OGG1 expression in normal epithelium was observed as 8-OHdG levels increased (P = 0.0011).	8-ohdg	68-74	8-oxoguanine DNA glycosylase	Homo sapiens	15-19
24437944-4	2014	In this study, NGR1 preconditioning provided neuroprotective effects via suppressing H2O2-induced the intracellular ROS accumulation, the increase in the product of lipid peroxidation (MDA), protein oxidation (protein carbonyl), and DNA fragmentation (8-OHdG), and mitochondrial membrane depolarization as well as caspase-3 activation.	8-ohdg	252-258	reticulon 4 receptor	Rattus norvegicus	15-19
24555497-5	2014	These miRNAs interacted antagonistically with SigmaOH-PAHs and BPDE-Alb adducts (betainteraction &lt; 0) and synergistically with drinking status (betainteraction &gt; 0) to influence 8-OH-dG, while they interacted synergistically with BPDE-Alb adducts (betainteraction &gt; 0) and antagonistically with smoking status (betainteraction &lt; 0) to influence 8-iso-PGF2alpha.	8-ohdg	184-191	albumin	Homo sapiens	68-71
24555497-5	2014	These miRNAs interacted antagonistically with SigmaOH-PAHs and BPDE-Alb adducts (betainteraction &lt; 0) and synergistically with drinking status (betainteraction &gt; 0) to influence 8-OH-dG, while they interacted synergistically with BPDE-Alb adducts (betainteraction &gt; 0) and antagonistically with smoking status (betainteraction &lt; 0) to influence 8-iso-PGF2alpha.	8-ohdg	184-191	albumin	Homo sapiens	241-244
24720751-0	2014	Expression of airway remodeling proteins in mast cell activated by TGF-beta released in OVA-induced allergic responses and their inhibition by low-dose irradiation or 8-oxo-dG.	8-ohdg	167-175	transforming growth factor, beta 1	Mus musculus	67-75
24720751-11	2014	The data suggest that mast cells induce expression of ECM proteins through TGF-beta produced in inflammatory cells of OVA mice and that post treatment of irradiation or 8-oxo-dG after OVA-challenge may reduce airway remodeling through down-regulating mast cell re-activation by TGF-beta/Smad signals.	8-ohdg	169-177	transforming growth factor, beta 1	Mus musculus	75-83
24720751-11	2014	The data suggest that mast cells induce expression of ECM proteins through TGF-beta produced in inflammatory cells of OVA mice and that post treatment of irradiation or 8-oxo-dG after OVA-challenge may reduce airway remodeling through down-regulating mast cell re-activation by TGF-beta/Smad signals.	8-ohdg	169-177	transforming growth factor, beta 1	Mus musculus	278-286
24347047-5	2014	The results suggest that p38 MAPK/PMK-1 plays protective role against AgNP-mediated toxicity, reduced viability and greater accumulation of 8OHdG was observed in AgNP-treated KD cells, and in pmk-1 mutant worms compared with their WT counterparts, respectively.	8-ohdg	140-145	mitogen-activated protein kinase 14	Homo sapiens	25-28
24190502-8	2014	The persistent accumulation of DNA 8-OH-dG lesions in Ogg1-/- cells during the complete course of the exposure suggests a relevant role in arsenic-associated carcinogenic risk in turn.	8-ohdg	35-42	8-oxoguanine DNA glycosylase	Homo sapiens	54-58
24361613-8	2014	Changes in superoxide, 8-OHdG, glutathione and nitrotyrosine levels indicated that HSA-Trx significantly suppressed renal oxidative stress.	8-ohdg	23-29	thioredoxin 1	Mus musculus	87-90
24347047-5	2014	The results suggest that p38 MAPK/PMK-1 plays protective role against AgNP-mediated toxicity, reduced viability and greater accumulation of 8OHdG was observed in AgNP-treated KD cells, and in pmk-1 mutant worms compared with their WT counterparts, respectively.	8-ohdg	140-145	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	34-39
24347047-5	2014	The results suggest that p38 MAPK/PMK-1 plays protective role against AgNP-mediated toxicity, reduced viability and greater accumulation of 8OHdG was observed in AgNP-treated KD cells, and in pmk-1 mutant worms compared with their WT counterparts, respectively.	8-ohdg	140-145	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	192-197
24347047-7	2014	Interestingly, the absence or depletion of p38 MAPK/PMK-1 caused impaired and additive effects in AgNP-induced ndx-4(ok1003); pmk-1(RNAi) mutant survival, and hOGG1 and NDX-4 expression and enzyme activity, which may lead to higher accumulation of 8OHdG.	8-ohdg	248-253	mitogen-activated protein kinase 14	Homo sapiens	43-46
24347047-7	2014	Interestingly, the absence or depletion of p38 MAPK/PMK-1 caused impaired and additive effects in AgNP-induced ndx-4(ok1003); pmk-1(RNAi) mutant survival, and hOGG1 and NDX-4 expression and enzyme activity, which may lead to higher accumulation of 8OHdG.	8-ohdg	248-253	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	52-57
24516391-7	2014	Moreover, a loss-of-function mutation in Ogg1, which encodes a DNA repair enzyme that removes oxidatively damaged deoxyguanosine residues (8-hydroxy-2"-deoxyguanosine), did not significantly influence the somatic mtDNA mutation frequency of Sod2 mutants.	8-ohdg	139-166	8-oxoguanine DNA glycosylase	Drosophila melanogaster	41-45
24844833-9	2014	The DNA 8-oxo-dG levels in hOGG1 gene-deficient cells (2.48 +- 0.54) was 3.1 times compared with it in the control group (0.80 +- 0.16), the difference showed statistical significance (P &lt; 0.01).	8-ohdg	8-16	8-oxoguanine DNA glycosylase	Homo sapiens	27-32
24844833-10	2014	Whereas the 8-oxo-dG levels in hMTH1 gene-deficient cells (1.84 +- 0.46) was 2.3 times of it in the control group, the difference also showed statistical significance (P &lt; 0.01).	8-ohdg	12-20	nudix hydrolase 1	Homo sapiens	31-36
24333420-4	2014	8-Oxo-2"-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages.	8-ohdg	0-23	Rac family small GTPase 1	Mus musculus	93-97
24288393-7	2014	RESULTS: Staining of treated limbal tissue demonstrated the presence of 8-OHdG within p63 positive basal limbal cells.	8-ohdg	72-78	tumor protein p63	Homo sapiens	86-89
24451144-3	2014	Human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a key enzyme of the BER pathway and catalyzes the removal of 8-OHdG.	8-ohdg	109-115	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
24451144-12	2014	Urine 8-OHdG levels were significantly higher in subjects carrying the hOGG1 Ser variant than in those with the Cys/Cys genotype (p &lt; 0.03).	8-ohdg	6-12	8-oxoguanine DNA glycosylase	Homo sapiens	71-76
24424315-5	2014	We also demonstrated a protective effect of all three LF molecules against 8-hydroxydeoxyguanosine (8-OHdG) formation in calf thymus DNA following ultraviolet (UV) irradiation with H2O2.	8-ohdg	75-98	lactotransferrin	Bos taurus	54-56
24424315-5	2014	We also demonstrated a protective effect of all three LF molecules against 8-hydroxydeoxyguanosine (8-OHdG) formation in calf thymus DNA following ultraviolet (UV) irradiation with H2O2.	8-ohdg	100-106	lactotransferrin	Bos taurus	54-56
24304833-3	2014	8-Oxoguanosine DNA glycosylase-1 (OGG1) recognizes and removes 8-OHdG to prevent further DNA damage.	8-ohdg	63-69	8-oxoguanine DNA glycosylase	Rattus norvegicus	0-32
24304833-3	2014	8-Oxoguanosine DNA glycosylase-1 (OGG1) recognizes and removes 8-OHdG to prevent further DNA damage.	8-ohdg	63-69	8-oxoguanine DNA glycosylase	Rattus norvegicus	34-38
24304833-5	2014	The levels of mtDNA 8-OHdG and the presence of apurinic/apyrimidinic (AP) sites were decreased by 30% and 35%, respectively, in Adv-Ogg1 transduced cells (P &lt; 0.0001 and P &lt; 0.005, respectively).	8-ohdg	20-26	8-oxoguanine DNA glycosylase	Rattus norvegicus	132-136
24333420-4	2014	8-Oxo-2"-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages.	8-ohdg	0-23	Rac family small GTPase 2	Mus musculus	102-106
24333420-4	2014	8-Oxo-2"-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages.	8-ohdg	25-33	Rac family small GTPase 1	Mus musculus	93-97
24333420-4	2014	8-Oxo-2"-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages.	8-ohdg	25-33	Rac family small GTPase 2	Mus musculus	102-106
23888942-9	2014	Expression of miR-21 was negatively correlated with T-AOC, SOD and CAT, but positively correlated with 8-OHdG and hOGG1mRNA.	8-ohdg	103-109	microRNA 21	Homo sapiens	14-20
25038989-5	2014	Circulating mononuclear cells of patients with high cholesterol levels, insulin resistance, metabolic syndrome or obesity present lower levels of antioxidant enzymes and increased concentrations of oxidative stress by-products such as isoprostanes or the DNA oxidized and highly mutagenic base 8-oxo-7,8-dihydro-2"-deoxyguanosine.	8-ohdg	294-329	insulin	Homo sapiens	72-79
24035314-9	2014	Moreover, renal superoxide production and 8-hydroxydeoxyguanosine (8-OHdG) staining were more decreased in the SHR + PIN group than SHRs.	8-ohdg	42-65	dynein light chain LC8-type 1	Rattus norvegicus	117-120
24035314-9	2014	Moreover, renal superoxide production and 8-hydroxydeoxyguanosine (8-OHdG) staining were more decreased in the SHR + PIN group than SHRs.	8-ohdg	67-73	dynein light chain LC8-type 1	Rattus norvegicus	117-120
24314116-6	2013	RESULTS: There was a statistically significant association between first and last-day average PM2.5 and 8-OHdG (21% increase, 95% CI: 2, 42%) and first and last-day average OC and IL-6 levels (18% increase 95% CI: 1, 37%) per IQR in exposure.	8-ohdg	104-110	interleukin 6	Homo sapiens	180-184
22833520-8	2014	Induction of GSTP1 activity lowered endogenous ROS levels in LNCaP-pLPCX-GSTP1 cells, and when exposed to H2 O2 , these cells exhibited significantly reduced production of ROS and 8-OHdG levels, compared to vector control LNCaP-pLPCX cells.	8-ohdg	180-186	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-5	2014	We found significantly elevated (103%; P &lt; 0.0001) levels of 8-oxo-2"-deoxogunosine (8-OHdG), an oxidative DNA damage marker, in adenocarcinomas, compared to benign counterparts, which positively correlated (r = 0.2) with loss of GSTP1 activity (34%; P &lt; 0.0001).	8-ohdg	88-94	glutathione S-transferase pi 1	Homo sapiens	233-238
24321741-10	2013	This high prevalence of GST-P-positive hepatocytes was accompanied by higher levels of 8-hydroxydeoxyguanosine in serum and liver tissue.	8-ohdg	87-110	glutathione S-transferase pi 1	Rattus norvegicus	24-29
23917144-8	2013	Quantitative analysis of 8-oxodG revealed significantly increased levels in CD133- and/or Oct3/4-positive tumor tissues compared to negative tumor tissues, as well as 8-nitroguanine formation detected by immunohistochemistry.	8-ohdg	25-32	prominin 1	Homo sapiens	76-81
24084170-5	2013	XPC has additionally been implicated in recognition of bulky (e.g. cyclopurines) and non-bulky DNA damage (8-oxodG).	8-ohdg	107-114	xeroderma pigmentosum, complementation group C	Mus musculus	0-3
22941157-0	2013	Cigarette smoking and hOGG1 Ser326Cys polymorphism are associated with 8-OHdG accumulation on mitochondrial DNA in thoracic esophageal squamous cell carcinoma.	8-ohdg	71-77	8-oxoguanine DNA glycosylase	Homo sapiens	22-27
23455180-8	2013	Keap1 [estimate, 0.49; 95% confidence interval (CI), 0.19-0.79] and Bach1 (estimate, 0.24; 95% CI, 0.11-0.38) were significant predictors for the expression of 8-OHdG and had the closest proximity to Nrf2 in the cluster dendrogram of the tumor and distant normal tissues, respectively.	8-ohdg	160-166	kelch like ECH associated protein 1	Homo sapiens	0-5
23455180-8	2013	Keap1 [estimate, 0.49; 95% confidence interval (CI), 0.19-0.79] and Bach1 (estimate, 0.24; 95% CI, 0.11-0.38) were significant predictors for the expression of 8-OHdG and had the closest proximity to Nrf2 in the cluster dendrogram of the tumor and distant normal tissues, respectively.	8-ohdg	160-166	BTB domain and CNC homolog 1	Homo sapiens	68-73
23455180-8	2013	Keap1 [estimate, 0.49; 95% confidence interval (CI), 0.19-0.79] and Bach1 (estimate, 0.24; 95% CI, 0.11-0.38) were significant predictors for the expression of 8-OHdG and had the closest proximity to Nrf2 in the cluster dendrogram of the tumor and distant normal tissues, respectively.	8-ohdg	160-166	NFE2 like bZIP transcription factor 2	Homo sapiens	200-204
23917144-8	2013	Quantitative analysis of 8-oxodG revealed significantly increased levels in CD133- and/or Oct3/4-positive tumor tissues compared to negative tumor tissues, as well as 8-nitroguanine formation detected by immunohistochemistry.	8-ohdg	25-32	POU class 5 homeobox 1	Homo sapiens	90-96
23329365-7	2013	RESULTS: The 8-OHdG content in the liver tissue of NASH-HCC patients was significantly different from that in the other patients.	8-ohdg	13-19	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	51-55
24337843-6	2013	In particular, levels of Hsp70 were inversely correlated with 8-OHdG, DNA damage and cell apoptosis.	8-ohdg	62-68	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
24090815-3	2013	Significant increase of P450 total content and hydroxyl radical levels by low, high doses of ETBE and PB treatments at weeks 1 and 2, and 8-OHdG formation at week 2, accompanied accumulation of CYP2B1/2B2, CYP3A1/3A2 and CYP2C6, and downregulation of DNA oxoguanine glycosylase 1, induction of apoptosis and cell cycle arrest in hepatocytes, respectively.	8-ohdg	138-144	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	194-200
24090815-3	2013	Significant increase of P450 total content and hydroxyl radical levels by low, high doses of ETBE and PB treatments at weeks 1 and 2, and 8-OHdG formation at week 2, accompanied accumulation of CYP2B1/2B2, CYP3A1/3A2 and CYP2C6, and downregulation of DNA oxoguanine glycosylase 1, induction of apoptosis and cell cycle arrest in hepatocytes, respectively.	8-ohdg	138-144	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	206-212
23329365-9	2013	Multivariate analysis using hepatic 8-OHdG content as a factor in addition to age and fasting blood sugar revealed a significant difference in clinicopathological factors between NASH-HCC and NASH without HCC cases.	8-ohdg	36-42	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	179-187
23329365-9	2013	Multivariate analysis using hepatic 8-OHdG content as a factor in addition to age and fasting blood sugar revealed a significant difference in clinicopathological factors between NASH-HCC and NASH without HCC cases.	8-ohdg	36-42	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	179-183
23369609-2	2013	Human 8-oxoguanine glycosylase 1 (hOGG1), a key DNA repair gene, recognizes and excises 8-OHdG from damaged DNA accurately; however, a c.977C&gt;G (Ser326Cys) polymorphism in hOGG1 can inhibit the gene"s ability to remove 8-OHdG.	8-ohdg	88-94	8-oxoguanine DNA glycosylase	Homo sapiens	34-39
23815362-4	2013	Here, we show that administration of the Growth Hormone Releasing Hormone (GHRH) agonist JI-34 attenuates IH-induced neurocognitive deficits, anxiety, and depression in mice along with reduction in oxidative stress markers such as MDA and 8-hydroxydeoxyguanosine, and increases in hypoxia inducible factor-1alpha DNA binding and up-regulation of insulin growth factor-1 and erythropoietin expression.	8-ohdg	239-262	growth hormone releasing hormone	Mus musculus	41-73
23815362-4	2013	Here, we show that administration of the Growth Hormone Releasing Hormone (GHRH) agonist JI-34 attenuates IH-induced neurocognitive deficits, anxiety, and depression in mice along with reduction in oxidative stress markers such as MDA and 8-hydroxydeoxyguanosine, and increases in hypoxia inducible factor-1alpha DNA binding and up-regulation of insulin growth factor-1 and erythropoietin expression.	8-ohdg	239-262	growth hormone releasing hormone	Mus musculus	75-79
24499054-5	2013	Linear regression analysis was used to examine the associations of urinary 8-OHdG with TC, HDL-C and LDL-C levels with adjustment for sex, age, smoking and body mass index.	8-ohdg	75-81	component of oligomeric golgi complex 2	Homo sapiens	101-106
24499054-8	2013	RESULTS: After multivariate adjustment, urinary 8-OHdG levels were inversely associated with serum TC levels (beta = -0.0015, p &lt; 0.05) and LDL-C levels (beta = -0.0012, p = 0.07).	8-ohdg	48-54	component of oligomeric golgi complex 2	Homo sapiens	143-148
24165045-3	2013	Present work aims to investigate whether the expression of 8-OHdG and its key repair gene hOGG1 play distinctive role in two types of serous ovarian cancer.	8-ohdg	59-65	8-oxoguanine DNA glycosylase	Homo sapiens	90-95
23369609-2	2013	Human 8-oxoguanine glycosylase 1 (hOGG1), a key DNA repair gene, recognizes and excises 8-OHdG from damaged DNA accurately; however, a c.977C&gt;G (Ser326Cys) polymorphism in hOGG1 can inhibit the gene"s ability to remove 8-OHdG.	8-ohdg	88-94	8-oxoguanine DNA glycosylase	Homo sapiens	175-180
23369609-2	2013	Human 8-oxoguanine glycosylase 1 (hOGG1), a key DNA repair gene, recognizes and excises 8-OHdG from damaged DNA accurately; however, a c.977C&gt;G (Ser326Cys) polymorphism in hOGG1 can inhibit the gene"s ability to remove 8-OHdG.	8-ohdg	222-228	8-oxoguanine DNA glycosylase	Homo sapiens	34-39
23369609-2	2013	Human 8-oxoguanine glycosylase 1 (hOGG1), a key DNA repair gene, recognizes and excises 8-OHdG from damaged DNA accurately; however, a c.977C&gt;G (Ser326Cys) polymorphism in hOGG1 can inhibit the gene"s ability to remove 8-OHdG.	8-ohdg	222-228	8-oxoguanine DNA glycosylase	Homo sapiens	175-180
23714170-8	2013	There were statistically significant positive correlations between the salivary 8-OHdG levels and GI in the DS-1, DS-2 and C-2 groups, but not in the C-1.	8-ohdg	80-86	mitochondrial ribosomal protein L58	Homo sapiens	108-112
23797467-8	2013	Levels of 8-oxo-dG were correlated with EGFR mutations (36% vs 16%; P = .012).	8-ohdg	10-18	epidermal growth factor receptor	Homo sapiens	40-44
23714170-8	2013	There were statistically significant positive correlations between the salivary 8-OHdG levels and GI in the DS-1, DS-2 and C-2 groups, but not in the C-1.	8-ohdg	80-86	complement C2	Homo sapiens	123-126
23907605-6	2013	In addition, AFG1 increased 8-OHdG and gammaH2AX in the nuclies and induced S phase arrest and DNA damage in B-2A13 cells, and the proteins related to DNA damage responses, such as ATM, ATR, Chk2, p53, BRCA1, and gammaH2AX, were activated.	8-ohdg	28-34	AFG1 like ATPase	Homo sapiens	13-17
23714170-9	2013	There were also statistically significant positive correlations between salivary 8-OHdG levels and PD in the DS-2 and C-2 groups, but not in the DS-1 or C-1 groups.	8-ohdg	81-87	complement C2	Homo sapiens	118-121
23714170-10	2013	The salivary levels of 8-OHdG of DS-1 and DS-2 groups were significantly higher than in the C-l and C-2 groups, respectively.	8-ohdg	23-29	mitochondrial ribosomal protein L58	Homo sapiens	33-37
23872129-4	2013	Etoposide induced a significant down-regulation of mRNA expression of the OGG1 repair gene and marked biochemical alterations characteristic of oxidative DNA stress, including increased 8-OHdG, enhanced lipid peroxidation and reduction in reduced glutathione.	8-ohdg	186-192	8-oxoguanine DNA-glycosylase 1	Mus musculus	74-78
24416632-8	2013	Those with GSTM1 coding for the functional antioxidant enzyme Glutathione S-transferase (GST), had higher CD4 cell count (beta=3.48, p=0.034), lower HIV viral load (beta=-0.536, p=0.018), and lower mitochondrial 8-oxo-dG (beta=-0.28, p=0.03).	8-ohdg	212-220	glutathione S-transferase mu 1	Homo sapiens	11-16
23859636-8	2013	RESULTS: the treatment of diabetic rats with the anti-TNF-alpha caused a significant decrease in the TNF-alpha mRNA expression, which were paralleled with the decreased levels of TNF-alpha, IL-6, MOP, HSP-70, ICAM-1, VCAM-1, troponin-t and 8-OHdG in the blood serum.	8-ohdg	240-246	tumor necrosis factor	Rattus norvegicus	54-63
23859636-8	2013	RESULTS: the treatment of diabetic rats with the anti-TNF-alpha caused a significant decrease in the TNF-alpha mRNA expression, which were paralleled with the decreased levels of TNF-alpha, IL-6, MOP, HSP-70, ICAM-1, VCAM-1, troponin-t and 8-OHdG in the blood serum.	8-ohdg	240-246	tumor necrosis factor	Rattus norvegicus	101-110
23859636-8	2013	RESULTS: the treatment of diabetic rats with the anti-TNF-alpha caused a significant decrease in the TNF-alpha mRNA expression, which were paralleled with the decreased levels of TNF-alpha, IL-6, MOP, HSP-70, ICAM-1, VCAM-1, troponin-t and 8-OHdG in the blood serum.	8-ohdg	240-246	tumor necrosis factor	Rattus norvegicus	101-110
23859636-11	2013	CONCLUSION: these new findings suggested that targeting TNF-alpha could effectively reduce expressions of MCP-1, HSP-70, troponin-t, 8-OHdG and VCAM- 1, along with prominent reduction in MPO and IL-6 levels.	8-ohdg	133-139	tumor necrosis factor	Rattus norvegicus	56-65
24416632-8	2013	Those with GSTM1 coding for the functional antioxidant enzyme Glutathione S-transferase (GST), had higher CD4 cell count (beta=3.48, p=0.034), lower HIV viral load (beta=-0.536, p=0.018), and lower mitochondrial 8-oxo-dG (beta=-0.28, p=0.03).	8-ohdg	212-220	glutathione S-transferase kappa 1	Homo sapiens	62-87
24416632-8	2013	Those with GSTM1 coding for the functional antioxidant enzyme Glutathione S-transferase (GST), had higher CD4 cell count (beta=3.48, p=0.034), lower HIV viral load (beta=-0.536, p=0.018), and lower mitochondrial 8-oxo-dG (beta=-0.28, p=0.03).	8-ohdg	212-220	glutathione S-transferase kappa 1	Homo sapiens	11-14
24416632-10	2013	HIV/HCV co-infected participants with the GSTM1 coding for the functional antioxidant enzyme also had lower HIV viral load, lower 8-oxo-dG and lower rate of apoptosis, but also higher oxidized glutathione.	8-ohdg	130-138	glutathione S-transferase mu 1	Homo sapiens	42-47
23936466-2	2013	The polymorphic AluYb8 insertion in the 15(th) intron of the MUTYH gene (AluYb8MUTYH) has been shown to associate with an aggregated 8-hydroxy-2"-deoxyguanosine (8-OH-dG) lesion in genomic DNA and to serve as a risk factor for age-related diseases.	8-ohdg	133-160	mutY DNA glycosylase	Homo sapiens	61-66
23678040-4	2013	Inhibition of the mTOR pathway resulted in downregulation of renal tissue p53 expression, associated downstream signaling, and decreased number of sclerosed glomeruli, tubular microcysts, and apoptosed and 8-hydroxy deoxyguanosine (8-OHdG)-positive (+ve) cells in Tg26 mice.	8-ohdg	206-230	mechanistic target of rapamycin kinase	Mus musculus	18-22
23678040-4	2013	Inhibition of the mTOR pathway resulted in downregulation of renal tissue p53 expression, associated downstream signaling, and decreased number of sclerosed glomeruli, tubular microcysts, and apoptosed and 8-hydroxy deoxyguanosine (8-OHdG)-positive (+ve) cells in Tg26 mice.	8-ohdg	232-238	mechanistic target of rapamycin kinase	Mus musculus	18-22
23936466-2	2013	The polymorphic AluYb8 insertion in the 15(th) intron of the MUTYH gene (AluYb8MUTYH) has been shown to associate with an aggregated 8-hydroxy-2"-deoxyguanosine (8-OH-dG) lesion in genomic DNA and to serve as a risk factor for age-related diseases.	8-ohdg	162-169	mutY DNA glycosylase	Homo sapiens	61-66
23658396-9	2013	CONCLUSIONS: We observed positive association between 8-oxodG excretion and risk of especially ER-positive breast cancer.	8-ohdg	54-61	estrogen receptor 1	Homo sapiens	95-97
23712533-2	2013	The purpose of this study was to develop a sensitive method to accurately and rapidly quantify the 8-OHdG by using CE-LIF detection.	8-ohdg	99-105	leukemia inhibitory factor	Mus musculus	118-121
23813448-2	2013	The senescence-accelerated mouse prone 8 (SAMP8) is a mouse model containing a suite of naturally occurring mutations resulting in an accelerated senescence phenotype largely mediated by oxidative stress, which is further enhanced by a mutation in the Ogg1 gene, greatly reducing the ability of the enzyme to excise 8-hydroxy,2"-deoxyguanosine (8OHdG) adducts.	8-ohdg	316-343	8-oxoguanine DNA-glycosylase 1	Mus musculus	252-256
23813448-2	2013	The senescence-accelerated mouse prone 8 (SAMP8) is a mouse model containing a suite of naturally occurring mutations resulting in an accelerated senescence phenotype largely mediated by oxidative stress, which is further enhanced by a mutation in the Ogg1 gene, greatly reducing the ability of the enzyme to excise 8-hydroxy,2"-deoxyguanosine (8OHdG) adducts.	8-ohdg	345-350	8-oxoguanine DNA-glycosylase 1	Mus musculus	252-256
23745771-3	2013	We found that the total concentration of urinary PAH metabolites and plasma BPDE-Alb adducts were both significantly associated with increased 8-OHdG and 8-iso-PGF2alpha in both smokers and nonsmokers (all p &lt; 0.05).	8-ohdg	143-149	albumin	Homo sapiens	81-84
23765754-13	2013	Fetuin A was found to be positively correlated with HOMA-IR (r:0,40, P&lt;0.05) and negatively correlated with 8-hydroxydeoxyguanosine (r:-0,52, P&lt;0.01).	8-ohdg	111-134	alpha-2-HS-glycoprotein	Mus musculus	0-8
23765754-15	2013	In conclusion, serum level of fetuin A is high in morbidly obese subjects and is negatively associated with 8-hydroxydeoxyguanosine level in peripheral circulation.	8-ohdg	108-131	alpha-2-HS-glycoprotein	Mus musculus	30-38
23622820-2	2013	Anti-CD40 Ab and 8-oxo-dG reduced EAE scores, mast cell numbers, expression of adhesion molecules, OX40L and Act1, levels of TNF-alpha, LTs, expression of cytokines, and co-localization of Treg cells and mast cells, all of which are increased in EAE-brain tissues.	8-ohdg	17-25	TNF superfamily member 4	Homo sapiens	99-104
23622820-2	2013	Anti-CD40 Ab and 8-oxo-dG reduced EAE scores, mast cell numbers, expression of adhesion molecules, OX40L and Act1, levels of TNF-alpha, LTs, expression of cytokines, and co-localization of Treg cells and mast cells, all of which are increased in EAE-brain tissues.	8-ohdg	17-25	TRAF3 interacting protein 2	Homo sapiens	109-113
23622820-2	2013	Anti-CD40 Ab and 8-oxo-dG reduced EAE scores, mast cell numbers, expression of adhesion molecules, OX40L and Act1, levels of TNF-alpha, LTs, expression of cytokines, and co-localization of Treg cells and mast cells, all of which are increased in EAE-brain tissues.	8-ohdg	17-25	tumor necrosis factor	Homo sapiens	125-134
23622820-5	2013	The data suggest that IL-10- and IL-35-producing Foxp3+-Treg cells, enhanced by anti-CD40 Ab or 8-oxo-dG, suppress migration of mast cells through down-regulating the expression of adhesion molecules, and suppress mast cell activation through cell-to-cell cross-talk via OX40/OX40L in EAE development.	8-ohdg	96-104	interleukin 10	Homo sapiens	22-38
23622820-5	2013	The data suggest that IL-10- and IL-35-producing Foxp3+-Treg cells, enhanced by anti-CD40 Ab or 8-oxo-dG, suppress migration of mast cells through down-regulating the expression of adhesion molecules, and suppress mast cell activation through cell-to-cell cross-talk via OX40/OX40L in EAE development.	8-ohdg	96-104	forkhead box P3	Homo sapiens	49-54
23874641-10	2013	Since 8-oxodG level in sperm DNA is inversely correlated with urinary excretion rate of 8-oxoGua, which is the product of OGG1 activity, we hypothesize that integrity of spermatozoa DNA may be highly dependent on OGG1 activity.	8-ohdg	6-13	8-oxoguanine DNA glycosylase	Homo sapiens	122-126
23874641-10	2013	Since 8-oxodG level in sperm DNA is inversely correlated with urinary excretion rate of 8-oxoGua, which is the product of OGG1 activity, we hypothesize that integrity of spermatozoa DNA may be highly dependent on OGG1 activity.	8-ohdg	6-13	8-oxoguanine DNA glycosylase	Homo sapiens	213-217
23491024-1	2013	OBJECTIVES: In this study, we explored the association between a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), and genetic polymorphism of the carcinogen-metabolizing enzyme N-acetyltransferase 2 (NAT2) among 4,4"-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.	8-ohdg	93-116	N-acetyltransferase 2	Homo sapiens	190-211
23491024-1	2013	OBJECTIVES: In this study, we explored the association between a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), and genetic polymorphism of the carcinogen-metabolizing enzyme N-acetyltransferase 2 (NAT2) among 4,4"-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.	8-ohdg	118-124	N-acetyltransferase 2	Homo sapiens	190-211
23491024-1	2013	OBJECTIVES: In this study, we explored the association between a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), and genetic polymorphism of the carcinogen-metabolizing enzyme N-acetyltransferase 2 (NAT2) among 4,4"-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.	8-ohdg	118-124	N-acetyltransferase 2	Homo sapiens	213-217
23491024-6	2013	RESULTS: NAT2 polymorphism influenced the plasma 8-OHdG levels of MBOCA-exposed workers, but not of non-exposed workers.	8-ohdg	49-55	N-acetyltransferase 2	Homo sapiens	9-13
23491024-11	2013	We suggest that the impact of the NAT2 acetylator status is low, if at all, on the generation of the oxidative stress marker 8-OHdG in the investigated exposed group.	8-ohdg	125-131	N-acetyltransferase 2	Homo sapiens	34-38
23369758-5	2013	Furthermore, serum 8-OHdG levels were elevated in the APE1-148Glu allele carriers (Asp/Glu+Glu/Glu), in an allele dose-response manner, with the risk of vitiligo (Ptrend&lt;0.05).	8-ohdg	19-25	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	54-58
23536494-10	2013	In accordance with its induction of Nrf2 activation, genistein exerted a robust attenuation of oxidative DNA damage and lipid peroxidative damage in hippocampal CA1 neurons after GCI, as measured by immunofluorescence staining of the oxidative stress markers, 8-hydroxy-2-deoxyguanosine (8-OHdG) and 4-Hydroxynonenal (4-HNE).	8-ohdg	260-286	NFE2 like bZIP transcription factor 2	Rattus norvegicus	36-40
23536494-10	2013	In accordance with its induction of Nrf2 activation, genistein exerted a robust attenuation of oxidative DNA damage and lipid peroxidative damage in hippocampal CA1 neurons after GCI, as measured by immunofluorescence staining of the oxidative stress markers, 8-hydroxy-2-deoxyguanosine (8-OHdG) and 4-Hydroxynonenal (4-HNE).	8-ohdg	288-294	NFE2 like bZIP transcription factor 2	Rattus norvegicus	36-40
23129268-6	2013	The level of 8-hydroxy-2-deoxyguanosine, a marker of oxidative stress, was significantly greater in the DM group compared to the control group and it was significantly reduced in the C3G treated group.	8-ohdg	13-39	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	183-186
23369758-6	2013	In addition, we found that the APE1-148Glu variant increased the 8-OHdG levels of cultured human melanocytes treated with H2O2, without any impact on the endonuclease activity.	8-ohdg	65-71	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	31-35
23376476-5	2013	Our results demonstrated that both cigarette smoking and OGG1 polymorphism can affect the sperm 8-OHdG levels.	8-ohdg	96-102	8-oxoguanine DNA glycosylase	Homo sapiens	57-61
23536361-4	2013	Oxidative stress induced by chronic isoproterenol, detected by 8-OhDG was 15% greater, P=0.007, in AC5 Tg hearts, whereas protein expression of manganese superoxide dismutase (MnSOD) was reduced by 38%, indicating that the susceptibility of AC5 Tg to cardiomyopathy may be attributable to decreased MnSOD expression.	8-ohdg	63-69	adenylate cyclase 5	Mus musculus	99-102
23273867-8	2013	In the survival/agony period, urinary L-FABP/Cr under the cut-off value 31.3 might show that the survival/agony period was within 1 h. Under the cut-off value of urinary 8-OHdG/Cr, 17.8, might indicate that it is within 24 h. CONCLUSION: Urinary L-FABP/Cr may rise within a relatively short survival/agony period, and urinary 8-OHdG/Cr may increase when the damage continues longer.	8-ohdg	170-176	fatty acid binding protein 1	Homo sapiens	38-44
23273867-8	2013	In the survival/agony period, urinary L-FABP/Cr under the cut-off value 31.3 might show that the survival/agony period was within 1 h. Under the cut-off value of urinary 8-OHdG/Cr, 17.8, might indicate that it is within 24 h. CONCLUSION: Urinary L-FABP/Cr may rise within a relatively short survival/agony period, and urinary 8-OHdG/Cr may increase when the damage continues longer.	8-ohdg	326-332	fatty acid binding protein 1	Homo sapiens	38-44
23671725-9	2013	Hepatocellular nuclear APE-1 levels were positively correlated with hepatocellular 8-OHdG levels in both the HBV and HCV groups (HBV, r = 0.34, P &lt; 0.05; HCV, r = 0.54, P &lt; 0.01).	8-ohdg	83-89	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	23-28
23376476-7	2013	Stratified analysis found that the association between OGG1 polymorphism and sperm 8-OHdG levels was only observed among smokers with pack-years &gt;=5 but not among those subjects with pack-years&lt;5 (pack-years=packs smoked per dayxyears as a smoker).	8-ohdg	83-89	8-oxoguanine DNA glycosylase	Homo sapiens	55-59
23460202-1	2013	The MUTYH DNA-glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-2"-deoxyguanine (8-oxodG) lesion by removing adenine erroneously incorporated opposite the oxidized purine.	8-ohdg	114-121	mutY DNA glycosylase	Mus musculus	4-9
23466236-10	2013	RESULTS: In UVB-irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen-activated protein kinase (MAPK), ATF-2, and c-Jun, and MMP expression.	8-ohdg	40-48	activating transcription factor 2	Homo sapiens	141-146
23466236-10	2013	RESULTS: In UVB-irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen-activated protein kinase (MAPK), ATF-2, and c-Jun, and MMP expression.	8-ohdg	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
23283135-7	2013	Changes in the markers 8-hydroxy deoxyguanosine and malondialdehyde indicated that HSA-Trx significantly suppressed renal oxidative stress.	8-ohdg	23-47	thioredoxin	Homo sapiens	87-90
23496811-9	2013	DN+IS, DH, and DH+IS rats showed decreased renal expression of Nrf2 and its downstream target genes, heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1), and increased renal expression of 8-hydroxydeoxyguanosine (8-OHdG), a marker of reactive oxygen species (ROS), compared with DN.	8-ohdg	204-227	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
23496811-9	2013	DN+IS, DH, and DH+IS rats showed decreased renal expression of Nrf2 and its downstream target genes, heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1), and increased renal expression of 8-hydroxydeoxyguanosine (8-OHdG), a marker of reactive oxygen species (ROS), compared with DN.	8-ohdg	229-235	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
23524455-7	2013	CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG.	8-ohdg	106-112	ceruloplasmin	Homo sapiens	0-2
23507534-1	2013	MUTYH, a human ortholog of MutY, is a post-replicative DNA glycosylase, highly conserved throughout evolution, involved in the correction of mismatches resulting from a faulty replication of the oxidized base 8-hydroxyguanine (8-oxodG).	8-ohdg	227-234	mutY DNA glycosylase	Homo sapiens	0-5
23507534-2	2013	In particular removal of adenine from A:8-oxodG mispairs by MUTYH activity is followed by error-free base excision repair (BER) events, leading to the formation of C:8-oxodG base pairs.	8-ohdg	40-47	mutY DNA glycosylase	Homo sapiens	60-65
23507534-2	2013	In particular removal of adenine from A:8-oxodG mispairs by MUTYH activity is followed by error-free base excision repair (BER) events, leading to the formation of C:8-oxodG base pairs.	8-ohdg	166-173	mutY DNA glycosylase	Homo sapiens	60-65
23507534-3	2013	These are the substrate of another BER enzyme, the OGG1 DNA glycosylase, which then removes 8-oxodG from DNA.	8-ohdg	92-99	8-oxoguanine DNA glycosylase	Homo sapiens	51-55
22704122-10	2013	CD80 mRNA mucosal levels were directly correlated with 8-OHdG mucosal levels (tau=0.26, p=0.04), TLR4 protein expression (tau=0.45, p&lt;0.01) and NF-kappaB mRNA expression and activity (tau=0.24, p=0.02; tau=0.34, p=0.02, respectively).	8-ohdg	55-61	CD80 molecule	Homo sapiens	0-4
23022769-5	2013	Whereas Fenton reaction substrates, used separately, did not affect lipid peroxidation, they increased 8-oxodG level for the highest H(2)O(2) concentration (100mM) and in Fe(2+) concentration-dependent manner (300, 150, 30 and 15 muM).	8-ohdg	103-110	latexin	Homo sapiens	230-233
22939515-7	2013	Collectively, our data indicated that TCS reduced the levels of GDM and down-regulated the MBD2, MBD3, and MeCP2 gene expression by increasing 8-OHdG levels and inhibiting the DNMT1 activity in HepG2 cells.	8-ohdg	143-149	methyl-CpG binding domain protein 2	Homo sapiens	91-95
23788962-6	2013	A significant relation was found between 8-OHdG and HIF-1alpha in the patient group (p &lt; 0.01).	8-ohdg	41-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
22704122-11	2013	CD80 protein expression, instead, was directly correlated with 8-OHdG mucosal levels (tau=0.19, p=0.05) and inversely correlated with TLR4 mRNA expression (tau=-0.25, p=0.03).	8-ohdg	63-69	CD80 molecule	Homo sapiens	0-4
23293967-4	2013	We investigated the levels of 8- hydroxydeoxyguanosine (8-OHdG), one of the most sensitive biomarkers for measuring OS and the association between polymorphisms in Cytochrome P450 (CYP) and Glutathione S-Transferase (GST) genes that are known to play a significant role in the activation and detoxification of xenobiotics.	8-ohdg	56-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	181-184
23293967-9	2013	The results showed a significant increase in urinary 8-OHdG levels in mutated CYP1A1m1 (p &lt; 0.007) and null GSTM1 (p &lt; 0.01) genotypes.	8-ohdg	53-59	glutathione S-transferase mu 1	Homo sapiens	111-116
23738036-2	2013	For this purpose, we established an accurate and sensitive isotope-diluted LC-MS/MS method to determine the levels of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dGsn) in DNA and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) in RNA.	8-ohdg	118-153	gelsolin	Rattus norvegicus	162-165
22944044-5	2013	Antioxidant TEMPOL almost completely inhibited AGE3-induced TNF-alpha secretion, whereas NF-kappaB inhibitor PDTC partly suppressed AGE3-induced 8-OHdG production.	8-ohdg	145-151	nuclear factor kappa B subunit 1	Homo sapiens	89-98
23295371-9	2013	A significant correlation was found between the concentrations of AF EPO and meta-tyrosine/phenylalanine ratio (p &lt; 0.001), nitro-tyrosine (p &lt; 0.01) and 8-oxo-dG/2dG ratio (p &lt; 0.001).	8-ohdg	160-168	erythropoietin	Homo sapiens	69-72
23555748-7	2013	Both urine and serum 8-hydroxydeoxyguanosine(8-OHdG) levels were higher in the CsA+hATMSCs group than in the CsA group (P&lt;0.05).	8-ohdg	21-44	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	79-82
24062877-3	2013	In this study, 8-hydroxy-2-deoxy guanosine (8-OH-dG), a marker of oxidative stress, was used to assess the level of oxidative stress, and thioredoxin reductase 1 (TrxR1) and glutathione peroxidase 1 (GPx1) were assessed to reflect the level of selenoproteins.	8-ohdg	44-51	thioredoxin reductase 1	Homo sapiens	163-168
24062877-3	2013	In this study, 8-hydroxy-2-deoxy guanosine (8-OH-dG), a marker of oxidative stress, was used to assess the level of oxidative stress, and thioredoxin reductase 1 (TrxR1) and glutathione peroxidase 1 (GPx1) were assessed to reflect the level of selenoproteins.	8-ohdg	44-51	glutathione peroxidase 1	Homo sapiens	174-198
24062877-3	2013	In this study, 8-hydroxy-2-deoxy guanosine (8-OH-dG), a marker of oxidative stress, was used to assess the level of oxidative stress, and thioredoxin reductase 1 (TrxR1) and glutathione peroxidase 1 (GPx1) were assessed to reflect the level of selenoproteins.	8-ohdg	44-51	glutathione peroxidase 1	Homo sapiens	200-204
23555748-7	2013	Both urine and serum 8-hydroxydeoxyguanosine(8-OHdG) levels were higher in the CsA+hATMSCs group than in the CsA group (P&lt;0.05).	8-ohdg	45-51	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	79-82
23883737-9	2013	DSS-induced DNA damage and subsequent repair activity were evaluated by staining for 8-hydroxy-deoxyguanosine (8-OHdG) and APE1, respectively; 8-OHdG immunoreactivity increased throughout the colonic mucosa, while APE1 levels in the surface epithelium increased at an earlier timepoint.	8-ohdg	143-149	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	123-127
23883737-9	2013	DSS-induced DNA damage and subsequent repair activity were evaluated by staining for 8-hydroxy-deoxyguanosine (8-OHdG) and APE1, respectively; 8-OHdG immunoreactivity increased throughout the colonic mucosa, while APE1 levels in the surface epithelium increased at an earlier timepoint.	8-ohdg	143-149	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	214-218
23267669-9	2012	RESULTS: Both Fenton reaction substrates, used separately, increased 8-oxodG level for the highest H2O2 concentration of 100 mM and in Fe2+ concentration-dependent manner [300, 150, and 30 muM].When Fe2+ and H2O2 were applied together, Fe2+ enhanced H2O2 damaging effect to a higher degree than did H2O2 on Fe2+ effect.	8-ohdg	69-76	latexin	Homo sapiens	189-192
23394311-6	2013	A significant effect of combined GSTM1 and GSTA1 genotypes on the extent of oxidative damage was found only for 8-OHdG (P=0.018).	8-ohdg	112-118	glutathione S-transferase mu 1	Homo sapiens	33-38
23394311-6	2013	A significant effect of combined GSTM1 and GSTA1 genotypes on the extent of oxidative damage was found only for 8-OHdG (P=0.018).	8-ohdg	112-118	glutathione S-transferase alpha 1	Homo sapiens	43-48
23394311-7	2013	In addition, TCC patients with the most malignant tumors exhibited significantly higher frequencies of GSTM1-null or GSTA1-low activity genotypes, associated with a twofold increase in urinary 8-OHdG concentration (P=0.044).	8-ohdg	193-199	glutathione S-transferase mu 1	Homo sapiens	103-108
23394311-7	2013	In addition, TCC patients with the most malignant tumors exhibited significantly higher frequencies of GSTM1-null or GSTA1-low activity genotypes, associated with a twofold increase in urinary 8-OHdG concentration (P=0.044).	8-ohdg	193-199	glutathione S-transferase alpha 1	Homo sapiens	117-122
23085521-9	2012	After paraquat treatment, obvious 8-hydroxy-2"-deoxyguanosine and 4-hydroxy-2-nonenal reactivity was detected in the lungs of the xCT-deficient mice.	8-ohdg	34-61	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	130-133
22941760-2	2012	The aim of this study was to verify whether urinary 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, is a biomarker for SBMA.	8-ohdg	52-75	androgen receptor	Homo sapiens	133-137
22829015-11	2012	OGG1 mutations were found to accumulate more of 8-OHdG in smokers, which may serve as a biomarker for early diagnosis of laryngeal cancer.	8-ohdg	48-54	8-oxoguanine DNA glycosylase	Homo sapiens	0-4
23190830-6	2012	Zmpste24(-/-) wounds had decreased proliferation, increased 8-hydroxy-2"-deoxyguanosine levels, increased proapoptotic signaling (i.e., p53, PUMA, BAX), decreased antiapoptotic signaling (i.e., Bcl-2), and increased DNA fragmentation.	8-ohdg	60-87	zinc metallopeptidase, STE24	Mus musculus	0-8
22982460-4	2012	8-oxodG was positively correlated with systolic blood pressure, pulse pressure, and interleukin-23.	8-ohdg	0-7	interleukin 37	Homo sapiens	84-98
22941760-2	2012	The aim of this study was to verify whether urinary 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, is a biomarker for SBMA.	8-ohdg	77-83	androgen receptor	Homo sapiens	133-137
22941760-3	2012	METHODS: We measured the levels of urinary 8-OHdG in 33 genetically confirmed SBMA patients and 32 age-matched controls over a 24-month period at 6-month intervals.	8-ohdg	43-49	androgen receptor	Homo sapiens	78-82
22941760-4	2012	RESULTS: Urinary 8-OHdG levels in SBMA patients were significantly elevated compared with those of controls and correlated well with motor function scores.	8-ohdg	17-23	androgen receptor	Homo sapiens	34-38
22941760-7	2012	CONCLUSIONS: Urinary 8-OHdG is a biomarker for SBMA, reflecting the severity and possibly predicting the deterioration of motor function.	8-ohdg	21-27	androgen receptor	Homo sapiens	47-51
25538758-4	2012	Enzyme linked immunosorbent assay showed that 8-hydroxy-2-deoxy guanosine levels in Schwann cells decreased following ginsenoside Rb1 treatment.	8-ohdg	46-73	RB transcriptional corepressor 1	Homo sapiens	130-133
22989268-1	2012	A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2"-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study.	8-ohdg	63-86	8-oxoguanine DNA glycosylase	Homo sapiens	166-171
22541685-7	2012	RESULTS: Hepcidin-25 was associated positively with ferritin, high-sensitive C-reactive protein (hsCRP) and 8-OHdG, and negatively with eGFR and hemoglobin.	8-ohdg	108-114	hepcidin antimicrobial peptide	Homo sapiens	9-17
22841817-4	2012	Accumulation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) increased in photoreceptor cells, and especially within their nuclei, in rd10 mice as well as in Royal College of Surgeons rats, another model of RP caused by different genetic mutations.	8-ohdg	16-51	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	136-140
22841817-4	2012	Accumulation of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG) increased in photoreceptor cells, and especially within their nuclei, in rd10 mice as well as in Royal College of Surgeons rats, another model of RP caused by different genetic mutations.	8-ohdg	53-61	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	136-140
22841817-6	2012	Transgenic overexpression of human MutT homolog-1, which hydrolyzes oxidized purine nucleoside triphosphates in the nucleotide pool, significantly attenuated 8-oxo-dG accumulation in nuclear DNA and photoreceptor cell death in rd10 mice, in addition to suppressing DNA single-strand break formation, poly(ADP-ribose) polymerase activation, and nuclear translocation of apoptosis-inducing factor.	8-ohdg	158-166	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	227-231
22551092-5	2012	The results showed that the level of 8-OHdG in both SIF groups was significantly decreased compared to the Abeta1-42-treated group (p &lt; 0.05), while the mRNA and protein expression of OGG1 in the SIF + Abeta1-42 groups were up-regulated compared with the Abeta1-42-treated groups (p &lt; 0.05).	8-ohdg	37-43	8-oxoguanine DNA glycosylase	Rattus norvegicus	187-191
22568890-8	2012	Immunohistochemical intensity of 8-hydroxy-2"-deoxyguanosine was strikingly reduced in recombinant human TRX-injected mouse.	8-ohdg	33-60	thioredoxin	Homo sapiens	105-108
23259321-8	2012	Elevated 8-oxodG levels were observed in subjects with CYP1A1 CAC haplotype and GSTT1 null variant.	8-ohdg	9-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	55-61
23259321-8	2012	Elevated 8-oxodG levels were observed in subjects with CYP1A1 CAC haplotype and GSTT1 null variant.	8-ohdg	9-16	carbonic anhydrase 2	Homo sapiens	62-65
23259321-8	2012	Elevated 8-oxodG levels were observed in subjects with CYP1A1 CAC haplotype and GSTT1 null variant.	8-ohdg	9-16	glutathione S-transferase theta 1	Homo sapiens	80-85
22580124-0	2012	8-Hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation.	8-ohdg	0-26	Rac family small GTPase 1	Mus musculus	113-117
22764135-6	2012	UV-induced DNA damage, in the form of cyclopyrimidine dimers and 8-oxo-deoxyguanosine adducts, was eliminated earlier from CDC25A-deficient epidermis.	8-ohdg	65-85	cell division cycle 25A	Mus musculus	123-129
22641385-1	2012	The base excision repair gene MUTYH encodes glycosylase which removes adenine             residues mispaired with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-OHG).	8-ohdg	114-149	mutY DNA glycosylase	Homo sapiens	30-35
22641385-1	2012	The base excision repair gene MUTYH encodes glycosylase which removes adenine             residues mispaired with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-OHG).	8-ohdg	151-156	mutY DNA glycosylase	Homo sapiens	30-35
22580124-1	2012	8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, has been recently rediscovered to inhibit Rac1 in neutrophils and macrophages, thereby inhibiting Rac1-linked functions of these cells, including reactive oxygen species production through NADPH oxidase activation, phagocytosis, chemotaxis, and cytokine release.	8-ohdg	0-26	Rac family small GTPase 1	Mus musculus	109-113
22580124-1	2012	8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, has been recently rediscovered to inhibit Rac1 in neutrophils and macrophages, thereby inhibiting Rac1-linked functions of these cells, including reactive oxygen species production through NADPH oxidase activation, phagocytosis, chemotaxis, and cytokine release.	8-ohdg	0-26	Rac family small GTPase 1	Mus musculus	165-169
22580124-1	2012	8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, has been recently rediscovered to inhibit Rac1 in neutrophils and macrophages, thereby inhibiting Rac1-linked functions of these cells, including reactive oxygen species production through NADPH oxidase activation, phagocytosis, chemotaxis, and cytokine release.	8-ohdg	28-34	Rac family small GTPase 1	Mus musculus	109-113
22580124-1	2012	8-Hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, has been recently rediscovered to inhibit Rac1 in neutrophils and macrophages, thereby inhibiting Rac1-linked functions of these cells, including reactive oxygen species production through NADPH oxidase activation, phagocytosis, chemotaxis, and cytokine release.	8-ohdg	28-34	Rac family small GTPase 1	Mus musculus	165-169
22580124-4	2012	Partially ligated ApoE knockout mice, a more physiologically relevant model of low and oscillatory flow, developed an advanced lesion in 2 weeks, and orally administered 8-OHdG significantly reduced plaque formation along with reduced superoxide formation, monocyte/macrophage infiltration, and extracellular matrix (ECM) accumulation.	8-ohdg	170-176	apolipoprotein E	Mus musculus	18-22
22580124-6	2012	Also, angiotensin II-induced Rac1 activity in VSMCs was significantly inhibited by 8-OHdG, and transfection of constitutively active Rac1 reversed the inhibitory effect of 8-OHdG on VSMC activation.	8-ohdg	83-89	Rac family small GTPase 1	Mus musculus	29-33
22580124-6	2012	Also, angiotensin II-induced Rac1 activity in VSMCs was significantly inhibited by 8-OHdG, and transfection of constitutively active Rac1 reversed the inhibitory effect of 8-OHdG on VSMC activation.	8-ohdg	172-178	Rac family small GTPase 1	Mus musculus	29-33
22580124-6	2012	Also, angiotensin II-induced Rac1 activity in VSMCs was significantly inhibited by 8-OHdG, and transfection of constitutively active Rac1 reversed the inhibitory effect of 8-OHdG on VSMC activation.	8-ohdg	172-178	Rac family small GTPase 1	Mus musculus	133-137
22580124-7	2012	Molecular docking study showed that 8-OHdG stabilizes Rac1-GEF complex, indicating the physical contact of 8-OHdG with Rac1.	8-ohdg	36-42	Rac family small GTPase 1	Mus musculus	54-58
22580124-7	2012	Molecular docking study showed that 8-OHdG stabilizes Rac1-GEF complex, indicating the physical contact of 8-OHdG with Rac1.	8-ohdg	36-42	Rac family small GTPase 1	Mus musculus	119-123
22580124-7	2012	Molecular docking study showed that 8-OHdG stabilizes Rac1-GEF complex, indicating the physical contact of 8-OHdG with Rac1.	8-ohdg	107-113	Rac family small GTPase 1	Mus musculus	54-58
22580124-7	2012	Molecular docking study showed that 8-OHdG stabilizes Rac1-GEF complex, indicating the physical contact of 8-OHdG with Rac1.	8-ohdg	107-113	Rac family small GTPase 1	Mus musculus	119-123
22580124-8	2012	These findings highly suggest that the antiatherosclerotic effect of 8-OHdG is mediated by inhibition of Rac1 activity.	8-ohdg	69-75	Rac family small GTPase 1	Mus musculus	105-109
22580124-9	2012	In conclusion, our results show a novel action of orally active 8-OHdG in suppressing atherosclerotic plaque formation in vivo and VSMC activation in vitro through inhibition of Rac1, which emphasizes a new therapeutic avenue to benefit atherosclerosis.	8-ohdg	64-70	Rac family small GTPase 1	Mus musculus	178-182
22473985-10	2012	In addition, the content of 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) in transgenic seeds was reduced compared to wild-type seeds, indicating a DNA damage-repair function of AtOGG1 in vivo.	8-ohdg	57-65	8-oxoguanine-DNA glycosylase 1	Arabidopsis thaliana	171-177
22386653-6	2012	Further, full-length PEDF protein and P5-3 peptide significantly decreased 8-hydroxy-2"-deoxyguanosine and vascular endothelial growth factor (VEGF) levels in the corneal.	8-ohdg	75-102	serpin family F member 1	Rattus norvegicus	21-25
22386653-6	2012	Further, full-length PEDF protein and P5-3 peptide significantly decreased 8-hydroxy-2"-deoxyguanosine and vascular endothelial growth factor (VEGF) levels in the corneal.	8-ohdg	75-102	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-42
22451681-6	2012	Assessment of OGG1 activity using a 7,8-dihydro-8-oxodeoxyguanine (8-oxo dG) containing molecular beacon demonstrated that the activity of both Ser326- and Cys326-hOGG1 was increased following oxidative treatment but with different kinetics.	8-ohdg	67-75	8-oxoguanine DNA glycosylase	Homo sapiens	14-18
22451681-6	2012	Assessment of OGG1 activity using a 7,8-dihydro-8-oxodeoxyguanine (8-oxo dG) containing molecular beacon demonstrated that the activity of both Ser326- and Cys326-hOGG1 was increased following oxidative treatment but with different kinetics.	8-ohdg	67-75	8-oxoguanine DNA glycosylase	Homo sapiens	163-168
22579575-8	2012	The efficiency of 8-OH-dG repair was increased which could be related to increased activity of DNA glycosylase I (hOgg1).	8-ohdg	18-25	8-oxoguanine DNA glycosylase	Homo sapiens	114-119
22473985-10	2012	In addition, the content of 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) in transgenic seeds was reduced compared to wild-type seeds, indicating a DNA damage-repair function of AtOGG1 in vivo.	8-ohdg	28-55	8-oxoguanine-DNA glycosylase 1	Arabidopsis thaliana	171-177
22344408-7	2012	NCX 466, at the highest dose, was significantly more effective than naproxen in reducing the levels of the profibrotic cytokine transforming growth factor-beta and the oxidative stress markers thiobarbituric acid reactive substance and 8-hydroxy-2"-deoxyguanosine.	8-ohdg	236-263	T cell leukemia, homeobox 2	Mus musculus	0-3
22469707-9	2012	The lower lever of hOGG1 in CAG and GC with higher level of 8-OHdG implies that hOGG1 is closely related to oxidative DNA damage and may lead to carcinoma.	8-ohdg	60-66	8-oxoguanine DNA glycosylase	Homo sapiens	19-24
22469707-9	2012	The lower lever of hOGG1 in CAG and GC with higher level of 8-OHdG implies that hOGG1 is closely related to oxidative DNA damage and may lead to carcinoma.	8-ohdg	60-66	8-oxoguanine DNA glycosylase	Homo sapiens	80-85
22587342-8	2012	A positive correlation was observed among 8-OHdG levels, disease stage, telomerase activity, OGG1 polymorphisms and ALT/GGT levels.	8-ohdg	42-48	8-oxoguanine DNA glycosylase	Homo sapiens	93-97
22587342-9	2012	In HCC, miR-92 expression correlated positively with telomerase activity, 8-OHdG levels and Bad/Bax mRNA.	8-ohdg	74-80	microRNA 9-2	Homo sapiens	8-14
22348977-1	2012	A sensitive and accurate isotope-diluted LC-MS/MS method was developed for determination of 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dGsn), derived from DNA, and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), derived from RNA, in various tissue specimens obtained from normal SAMR1 and senescence-accelerated SAMP8 mice.	8-ohdg	92-127	gelsolin	Mus musculus	136-139
22146192-5	2012	The eventual enhancement of CK2 inhibition under ischemic injury strongly increased 8-hydroxy-2"-deoxyguanosine and phosphorylation of H2A.X.	8-ohdg	84-111	casein kinase 2, alpha prime polypeptide	Mus musculus	28-31
22285433-6	2012	The microsomal extracts and the individual catechols of alpha-ZAL, ZAN, E2 and E1 were found to induce oxidative DNA damage, as measured by the formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine in a cell-free system.	8-ohdg	157-192	zonadhesin	Homo sapiens	67-70
22285433-6	2012	The microsomal extracts and the individual catechols of alpha-ZAL, ZAN, E2 and E1 were found to induce oxidative DNA damage, as measured by the formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine in a cell-free system.	8-ohdg	157-192	cystatin 12, pseudogene	Homo sapiens	72-81
22115963-5	2012	There was a significant increase in the occurrence of the mutagenic base 8-oxo-2"-deoxiguanosine (8-oxo-dG) in the lymphocytes and urine of MBL and CLL patients compared with controls.	8-ohdg	98-106	mannose binding lectin 2	Homo sapiens	140-143
22444586-1	2012	MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine.	8-ohdg	147-182	mutY DNA glycosylase	Homo sapiens	29-34
22342844-5	2012	Both binding of oxidized mtDNA to the NLRP3 inflammasome and IL-1beta secretion could be competitively inhibited by the oxidized nucleoside 8-OH-dG.	8-ohdg	140-147	NLR family pyrin domain containing 3	Homo sapiens	38-43
22342844-5	2012	Both binding of oxidized mtDNA to the NLRP3 inflammasome and IL-1beta secretion could be competitively inhibited by the oxidized nucleoside 8-OH-dG.	8-ohdg	140-147	interleukin 1 beta	Homo sapiens	61-69
22206979-7	2012	Moreover, linear regression analysis showed that individuals carrying the PON1 Arg192Glu (rs662) or SOD2 Val16Ala (rs4880) variants have significantly higher levels of sperm DNA fragmentation and 8-OHdG.	8-ohdg	196-202	paraoxonase 1	Homo sapiens	74-78
21546615-8	2012	The percentage of TUNEL-positive sperm and the  levels of 8-OH-dG, MDA, and NO were higher but the sperm concentration and  motility and the TAC were lower in the patients with the GSTM1,  GSTT1, and GSTM1/T1 null genotypes than those in  the patients with the GSTM1, GSTT1, and  GSTM1/T1 present genotypes (P &lt; .05).	8-ohdg	58-65	glutathione S-transferase mu 1	Homo sapiens	181-186
23210982-6	2012	RESULTS: Strong 8-OHdG immunostaining intensity was associated with extranodal involvement (p = 0.00002), a high International Prognostic Index (p = 0.002) and strong Trx (p = 0.011) and GCL (p = 0.0003) expression.	8-ohdg	16-22	thioredoxin	Homo sapiens	167-170
23210982-6	2012	RESULTS: Strong 8-OHdG immunostaining intensity was associated with extranodal involvement (p = 0.00002), a high International Prognostic Index (p = 0.002) and strong Trx (p = 0.011) and GCL (p = 0.0003) expression.	8-ohdg	16-22	glutamate-cysteine ligase catalytic subunit	Homo sapiens	187-190
22240151-8	2012	Administration of AAV-SOD2 significantly reduced the levels of superoxide ion, MDA, 8-OHdG, and nitrotyrosine and prevented the damage to RGCs and IPL.	8-ohdg	84-90	superoxide dismutase 2	Rattus norvegicus	22-26
22268645-8	2012	Urinary levels of 5-meC were significantly positively correlated with N7-meG, N3-meA, and 8-oxodG.	8-ohdg	90-97	C-C motif chemokine ligand 28	Homo sapiens	20-23
22206979-7	2012	Moreover, linear regression analysis showed that individuals carrying the PON1 Arg192Glu (rs662) or SOD2 Val16Ala (rs4880) variants have significantly higher levels of sperm DNA fragmentation and 8-OHdG.	8-ohdg	196-202	superoxide dismutase 2	Homo sapiens	100-104
22009068-5	2012	Thus, the hOGG1 enzyme seems to be more specific towards oxidative DNA damage, such as 8-oxodG than Fpg.	8-ohdg	87-94	8-oxoguanine DNA glycosylase	Homo sapiens	10-15
22052073-10	2012	Furthermore, 8-OHdG/creatinine correlated with TNF-alpha, sTNF-R1, sTNF-R2 (P &lt; 0.0001), and with IL-6 (P &lt; 0.05).	8-ohdg	13-19	tumor necrosis factor	Homo sapiens	47-56
22052073-10	2012	Furthermore, 8-OHdG/creatinine correlated with TNF-alpha, sTNF-R1, sTNF-R2 (P &lt; 0.0001), and with IL-6 (P &lt; 0.05).	8-ohdg	13-19	interleukin 6	Homo sapiens	101-105
22052073-11	2012	A multivariate linear regression analysis showed that gender, smoking, and TNF-alpha were independent factors of 8-OHdG/creatinine.	8-ohdg	113-119	tumor necrosis factor	Homo sapiens	75-84
22052073-14	2012	TNF-alpha is an independent factor of 8-OHdG.	8-ohdg	38-44	tumor necrosis factor	Homo sapiens	0-9
22108520-2	2012	Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal.	8-ohdg	83-90	8-oxoguanine DNA glycosylase	Homo sapiens	32-37
22036650-6	2012	GLO-1-MCs had lower intracellular levels of MG accumulation, 8-hydroxy-deoxyguanosine (an oxidative DNA damage marker), 4-hydroxyl-2-nonenal (a lipid peroxidation product), and nitrosylated protein (a marker of oxidative-nitrosative stress) compared to control cells.	8-ohdg	61-85	glyoxalase 1	Mus musculus	0-5
21710244-7	2012	Additionally, we found that sex, smoking status, age, and c-reactive protein were related to urinary excretion of 8-oxoGuo and 8-oxodG in colorectal cancer patients.	8-ohdg	127-134	C-reactive protein	Homo sapiens	58-76
21987236-11	2012	The linear association between BNIP3 and 8-oxodG substantiates the role of BNIP3 as redox sensor as well as prognostic marker in breast cancer.	8-ohdg	41-48	BCL2 interacting protein 3	Homo sapiens	31-36
21987236-11	2012	The linear association between BNIP3 and 8-oxodG substantiates the role of BNIP3 as redox sensor as well as prognostic marker in breast cancer.	8-ohdg	41-48	BCL2 interacting protein 3	Homo sapiens	75-80
22081374-8	2012	A negative Spearmen correlation between XRCC1 vs. 8-OHdG in cases was observed.	8-ohdg	50-56	X-ray repair cross complementing 1	Homo sapiens	40-45
22009068-8	2012	The comet-hOGG1 assay will be used to detect oxidative DNA lesions (8-oxodG) in mussels exposed in situ.	8-ohdg	68-75	8-oxoguanine DNA glycosylase	Homo sapiens	10-15
22363173-3	2012	Our results with the colocalization of phosphorylated ATM and gamma-H2AX with 8-oxodG and 8-nitroguanine in inflammation-related cancer tissues suggest that DNA base damage leads to double-stranded breaks.	8-ohdg	78-85	ATM serine/threonine kinase	Homo sapiens	54-57
23244125-8	2012	However, posttreatment serum HIF-1alpha ve 8-OHdG levels was found lower than pretreatment levels in patients receiving metformin, but not with pioglitazone.	8-ohdg	43-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
22334795-7	2012	The 8-OHdG level was also significantly correlated with MMP-2 level (r = 0.551, P &lt; 0.05), but it was not correlated with the age of subjects, the duration of PD, or blood pressure.	8-ohdg	4-10	matrix metallopeptidase 2	Homo sapiens	56-61
21986195-4	2011	Furthermore, we found a significant increase in salivary cell 8-OHdG with respect to Ser/Cys and Cys/Cys genotypes of OGG1 in SCCHN cases, when compared to Ser/Ser and Ser/Cys genotypes of the control population.	8-ohdg	62-68	8-oxoguanine DNA glycosylase	Homo sapiens	118-122
22720119-5	2012	The average 8-OHdG/10(6) dG value was significantly higher in patients with the OGG1 c.977G, MUTYH c.972G or AluYb8MUTYH alleles (P &lt; 0.001 via ANOVA).	8-ohdg	12-18	8-oxoguanine DNA glycosylase	Homo sapiens	80-84
22720119-5	2012	The average 8-OHdG/10(6) dG value was significantly higher in patients with the OGG1 c.977G, MUTYH c.972G or AluYb8MUTYH alleles (P &lt; 0.001 via ANOVA).	8-ohdg	12-18	mutY DNA glycosylase	Homo sapiens	93-98
22720119-6	2012	Further analysis showed that combination of MUTYH c.972GG with OGG1 c.977GG or AluYb8MUTYH increased both the risk for ESRD and leukocyte DNA 8-OHdG levels in HD patients.	8-ohdg	142-148	mutY DNA glycosylase	Homo sapiens	44-49
22720119-6	2012	Further analysis showed that combination of MUTYH c.972GG with OGG1 c.977GG or AluYb8MUTYH increased both the risk for ESRD and leukocyte DNA 8-OHdG levels in HD patients.	8-ohdg	142-148	8-oxoguanine DNA glycosylase	Homo sapiens	63-67
23226323-5	2012	In response to genotoxic agents, cells depleted of annexin A2 show enhanced phospho-histone H2AX and p53 levels, increased numbers of p53-binding protein 1 nuclear foci and increased levels of nuclear 8-oxo-2"-deoxyguanine, suggesting that annexin A2 plays a role in protecting DNA from damage.	8-ohdg	201-222	annexin A2	Homo sapiens	51-61
23049824-8	2012	Se-lactoferrin eye drops suppressed the up-regulated expression of heme oxygenase-1, cyclooxygenase-2, matrix metallopeptidase-9, and interleukin-6 and also suppressed 8-OHdG production in the cornea induced by surgical removal of the lacrimal glands.	8-ohdg	168-174	lactotransferrin	Rattus norvegicus	3-14
22432007-7	2012	A transient increased expression of 8-OHdG, genes and proteins related to oxidative stress (OGG1, GPX, NFE2L2), was determined in ocular cells and corneas by HPLC, qRT-PCR and Western blot analysis.	8-ohdg	36-42	8-oxoguanine DNA glycosylase	Homo sapiens	92-96
22432007-7	2012	A transient increased expression of 8-OHdG, genes and proteins related to oxidative stress (OGG1, GPX, NFE2L2), was determined in ocular cells and corneas by HPLC, qRT-PCR and Western blot analysis.	8-ohdg	36-42	NFE2 like bZIP transcription factor 2	Homo sapiens	103-109
22433441-7	2012	However, in the DM + C3G group, 8-OHdG was statistically significantly reduced compared with the DM group.	8-ohdg	32-38	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	21-24
22906265-5	2012	Serum GGT levels were increased in all cases with ALD, NASH and fatty liver, and correlated significantly with serum levels of 8-OHdG in ALD and NASH, but not in simple fatty liver.	8-ohdg	127-133	inactive glutathione hydrolase 2	Homo sapiens	6-9
22906265-6	2012	CONCLUSIONS: Levels  of GGT in fatty liver patients may compensate for mild oxidative stress by repressing 8-OHdG levels and preventing progression to NASH; however further oxidative stress leads to increased levels of 8-OHdG and the development of NASH.	8-ohdg	107-113	inactive glutathione hydrolase 2	Homo sapiens	24-27
22906265-6	2012	CONCLUSIONS: Levels  of GGT in fatty liver patients may compensate for mild oxidative stress by repressing 8-OHdG levels and preventing progression to NASH; however further oxidative stress leads to increased levels of 8-OHdG and the development of NASH.	8-ohdg	219-225	inactive glutathione hydrolase 2	Homo sapiens	24-27
23155470-12	2012	As COX-2 and inflammatory mediators induce DNA oxidation, we measured 8-hydroxydeoxyguanosine (8-OHdG) in quiescent vs. proliferative fibroblasts.	8-ohdg	70-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	3-8
22479365-10	2012	Serum concentrations of 8-OHdG and HEL in the lactoferrin group were lower than those in the control group and were associated with attenuated 8-OHdG immunostaining of the lacrimal glands.	8-ohdg	24-30	lactotransferrin	Mus musculus	46-57
22479365-10	2012	Serum concentrations of 8-OHdG and HEL in the lactoferrin group were lower than those in the control group and were associated with attenuated 8-OHdG immunostaining of the lacrimal glands.	8-ohdg	143-149	lactotransferrin	Mus musculus	46-57
21908221-1	2011	BACKGROUND: The 8-hydroxydeoxyguanosine (8-OHdG) is widely used for determination of DNA damage since it is excised from oxidative damaged DNA with endonuclease repair enzymes coded by 8-oxoguanine DNA N-glycosylase gene (OGG1).	8-ohdg	41-47	8-oxoguanine DNA glycosylase	Homo sapiens	222-226
22001743-8	2011	An increase in 8-hydroxy-2"-deoxyguanosine, which is a marker of oxidative DNA damage, was detected only in areas where CYP1A1 was expressed, whereas the level of hexanoyl-lysine adduct, which is an initial marker of oxidative damage of phospholipids, did not increase.	8-ohdg	15-42	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	120-126
21908221-2	2011	The present study aimed at investigating whether hormone therapy (HT) may influence on the blood/urinary 8-OHdG levels and whether the level of 8-OHdG is different according to OGG1 S326C polymorphism in postmenopausal women receiving HT.	8-ohdg	144-150	8-oxoguanine DNA glycosylase	Homo sapiens	177-181
21908221-0	2011	The 8-hydroxydeoxyguanosine concentrations according to hormone therapy and S326C polymorphism of OGG1 gene in postmenopausal women.	8-ohdg	4-27	8-oxoguanine DNA glycosylase	Homo sapiens	98-102
21908221-1	2011	BACKGROUND: The 8-hydroxydeoxyguanosine (8-OHdG) is widely used for determination of DNA damage since it is excised from oxidative damaged DNA with endonuclease repair enzymes coded by 8-oxoguanine DNA N-glycosylase gene (OGG1).	8-ohdg	16-39	8-oxoguanine DNA glycosylase	Homo sapiens	222-226
21720711-5	2011	CSC induced 8-oxodG in a dose- (p=0.03) and time (p=0.002)-dependent fashion in ECT1/E6 E7 cells as determined by flow cytometry.	8-ohdg	12-19	fibroblast growth factor receptor 2	Homo sapiens	80-84
22196370-9	2011	Such 8-oxo-2"-deoxy-guanosine or 8-bromo-2"-deoxy-guanosine modifications of the first guanosine in GU-rich single-stranded RNAs convert the immune response to include TLR9 activation and demonstrate strong additive effects for type I IFN immune responses in human primary cells.	8-ohdg	5-29	toll like receptor 9	Homo sapiens	168-172
22196370-9	2011	Such 8-oxo-2"-deoxy-guanosine or 8-bromo-2"-deoxy-guanosine modifications of the first guanosine in GU-rich single-stranded RNAs convert the immune response to include TLR9 activation and demonstrate strong additive effects for type I IFN immune responses in human primary cells.	8-ohdg	5-29	interferon alpha 1	Homo sapiens	235-238
21827816-3	2011	A single dose of BaP to normal mice increased the level of 8-oxo-2"-deoxyguanosine (8-oxo-dG) content and % DNA in the comet tail in the lungs and liver.	8-ohdg	59-82	prohibitin 2	Mus musculus	17-20
21827816-3	2011	A single dose of BaP to normal mice increased the level of 8-oxo-2"-deoxyguanosine (8-oxo-dG) content and % DNA in the comet tail in the lungs and liver.	8-ohdg	84-92	prohibitin 2	Mus musculus	17-20
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	8-ohdg	135-143	prohibitin 2	Mus musculus	93-96
21997177-2	2011	Human 8-oxoguanine DNA glycosylase (hOGG1) is the key defense enzyme against mutation by the cellular 8-OHdG in duplex DNA.	8-ohdg	102-108	8-oxoguanine DNA glycosylase	Homo sapiens	6-34
21997177-2	2011	Human 8-oxoguanine DNA glycosylase (hOGG1) is the key defense enzyme against mutation by the cellular 8-OHdG in duplex DNA.	8-ohdg	102-108	8-oxoguanine DNA glycosylase	Homo sapiens	36-41
21864556-4	2011	Individuals with hOGG1 326Cys/Cys showed significantly higher urinary 8-OHdG concentrations than did those with 326 Ser/Cys and Ser/Ser.	8-ohdg	70-76	8-oxoguanine DNA glycosylase	Homo sapiens	17-22
21864556-5	2011	As for APE1 Asp148Glu, heterozygous subjects showed significantly higher urinary 8-OHdG concentrations than did those homozygous for Asp/Asp.	8-ohdg	81-87	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	7-11
22098435-11	2011	There was a negative correlation between 8-OHdG levels and PON1 activity only in the patient group (r=-0.536).	8-ohdg	41-47	paraoxonase 1	Homo sapiens	59-63
21873502-5	2011	OGG1 transgenic mice demonstrated significantly lower cardiac mitochondrial levels of the DNA guanine oxidation product 7,8-dihydro-8-oxoguanine (8-oxo-dG) under basal conditions, after doxorubicin administration, or after transaortic constriction (TAC), but the transgene produced no detectable reduction in nuclear 8-oxo-dG content.	8-ohdg	146-154	8-oxoguanine DNA-glycosylase 1	Mus musculus	0-4
21873502-5	2011	OGG1 transgenic mice demonstrated significantly lower cardiac mitochondrial levels of the DNA guanine oxidation product 7,8-dihydro-8-oxoguanine (8-oxo-dG) under basal conditions, after doxorubicin administration, or after transaortic constriction (TAC), but the transgene produced no detectable reduction in nuclear 8-oxo-dG content.	8-ohdg	317-325	8-oxoguanine DNA-glycosylase 1	Mus musculus	0-4
21824472-9	2011	Pretreatment of AAV-CAT significantly decreased the levels of H(2)O(2), MDA, 8-OHdG and nitrotyrosine, increased the catalase activity, and prevented the reduction of a- and b- waves in the I/R with AAV-CAT group compare with the I/R with vehicle group (p&lt;0.01).	8-ohdg	77-83	catalase	Rattus norvegicus	20-23
21763744-3	2011	Exposure to IL-1beta for 10 days increased (i) accumulation of 8-OHdG - a key biomarker of oxidative DNA damage; (ii) DNA damage response (DDR) indicators gammaH2AX, ATM and DNA-PK; (iii) nuclear and cytoplasmic p53 and COX-2 levels and (iv) interaction between COX-2 and p53.	8-ohdg	63-69	interleukin 1 beta	Homo sapiens	12-20
21778425-9	2011	Moreover, compared to streptozotocin-induced wild-type diabetic mice, endothelium-specific SIRT1 transgenic diabetic mice had decreased p66Shc expression at both the mRNA and the protein levels, improved endothelial function, and reduced accumulation of nitrotyrosine and 8-OHdG (markers of oxidative stress).	8-ohdg	272-278	sirtuin 1	Mus musculus	91-96
21620911-6	2011	Instead, the production of nitrotyrosine, 8-nitro-cGMP, and 8-hydroxy-2"-deoxyguanosine downstream to the iNOS has been inhibited.	8-ohdg	60-87	nitric oxide synthase 2, inducible	Mus musculus	106-110
21875576-4	2011	Immunohistochemical analysis revealed that mutagenic 8-nitroguanine and 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) were apparently formed in adenocarcinoma caused by mutated K-ras.	8-ohdg	72-107	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	177-182
21875576-4	2011	Immunohistochemical analysis revealed that mutagenic 8-nitroguanine and 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG) were apparently formed in adenocarcinoma caused by mutated K-ras.	8-ohdg	109-116	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	177-182
21733838-4	2011	8-OHdG treatment groups significantly reduced pathologic grade of DSS-induced colitis as well as various inflammatory mediators such as TNF-alpha, IL-6, COX-2, and iNOS in a dose-dependent manner.	8-ohdg	0-6	tumor necrosis factor	Mus musculus	136-145
21733838-4	2011	8-OHdG treatment groups significantly reduced pathologic grade of DSS-induced colitis as well as various inflammatory mediators such as TNF-alpha, IL-6, COX-2, and iNOS in a dose-dependent manner.	8-ohdg	0-6	interleukin 6	Mus musculus	147-151
21733838-4	2011	8-OHdG treatment groups significantly reduced pathologic grade of DSS-induced colitis as well as various inflammatory mediators such as TNF-alpha, IL-6, COX-2, and iNOS in a dose-dependent manner.	8-ohdg	0-6	cytochrome c oxidase II, mitochondrial	Mus musculus	153-158
21733838-4	2011	8-OHdG treatment groups significantly reduced pathologic grade of DSS-induced colitis as well as various inflammatory mediators such as TNF-alpha, IL-6, COX-2, and iNOS in a dose-dependent manner.	8-ohdg	0-6	nitric oxide synthase 2, inducible	Mus musculus	164-168
21733838-7	2011	Rac1 activity and phosphorylated STAT3 level were significantly attenuated in the 8-OHdG-treated group.	8-ohdg	82-88	Rac family small GTPase 1	Mus musculus	0-4
21733838-7	2011	Rac1 activity and phosphorylated STAT3 level were significantly attenuated in the 8-OHdG-treated group.	8-ohdg	82-88	signal transducer and activator of transcription 3	Mus musculus	33-38
21733838-8	2011	Significantly decreased levels of malondialdehyde, monocyte chemotactic protein-1, matrix metalloproteinasess, COX-2, NOX4, and beta-catenin nuclear accumulation were responsible for cancer prevention effects of exogenous 8-OHdG.	8-ohdg	222-228	chemokine (C-C motif) ligand 2	Mus musculus	51-81
21733838-8	2011	Significantly decreased levels of malondialdehyde, monocyte chemotactic protein-1, matrix metalloproteinasess, COX-2, NOX4, and beta-catenin nuclear accumulation were responsible for cancer prevention effects of exogenous 8-OHdG.	8-ohdg	222-228	cytochrome c oxidase II, mitochondrial	Mus musculus	111-116
21733838-8	2011	Significantly decreased levels of malondialdehyde, monocyte chemotactic protein-1, matrix metalloproteinasess, COX-2, NOX4, and beta-catenin nuclear accumulation were responsible for cancer prevention effects of exogenous 8-OHdG.	8-ohdg	222-228	NADPH oxidase 4	Mus musculus	118-122
21733838-8	2011	Significantly decreased levels of malondialdehyde, monocyte chemotactic protein-1, matrix metalloproteinasess, COX-2, NOX4, and beta-catenin nuclear accumulation were responsible for cancer prevention effects of exogenous 8-OHdG.	8-ohdg	222-228	catenin (cadherin associated protein), beta 1	Mus musculus	128-140
21415844-3	2011	RESULTS: Positive 8OHdG staining was significantly more frequent in the syncytiotrophoblasts from PIH pregnancies compared to normal pregnancies matched for maternal age/gestational age at delivery.	8-ohdg	18-23	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	98-101
21668583-1	2011	Human 8-oxoguanine DNA glycosylase-1 (hOGG1) is the key DNA repair enzyme responsible for initiating repair of UV radiation-induced 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	169-177	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
21668583-8	2011	Using comet assay we found that both hOGG1 and CSB knockdown reduced repair of both UVA- and UVB-induced 8-oxo-dG, consistent with CSB downregulation of hOGG1 mRNA and protein.	8-ohdg	105-113	8-oxoguanine DNA glycosylase	Homo sapiens	37-42
21668583-8	2011	Using comet assay we found that both hOGG1 and CSB knockdown reduced repair of both UVA- and UVB-induced 8-oxo-dG, consistent with CSB downregulation of hOGG1 mRNA and protein.	8-ohdg	105-113	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	47-50
21668583-10	2011	In engineered human skin, repair of UVA-induced 8-oxo-dG was inhibited by both hOGG1 and CSB knockdown, confirming the functional role of both proteins in cells with 3-D cellular contacts.	8-ohdg	48-56	8-oxoguanine DNA glycosylase	Homo sapiens	79-84
21668583-10	2011	In engineered human skin, repair of UVA-induced 8-oxo-dG was inhibited by both hOGG1 and CSB knockdown, confirming the functional role of both proteins in cells with 3-D cellular contacts.	8-ohdg	48-56	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	89-92
21668583-13	2011	Cockayne syndrome B could therefore be required for 8-oxo-dG repair due to its regulatory effect on hOGG1 expression.	8-ohdg	52-60	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	0-19
21668583-13	2011	Cockayne syndrome B could therefore be required for 8-oxo-dG repair due to its regulatory effect on hOGG1 expression.	8-ohdg	52-60	8-oxoguanine DNA glycosylase	Homo sapiens	100-105
21668583-1	2011	Human 8-oxoguanine DNA glycosylase-1 (hOGG1) is the key DNA repair enzyme responsible for initiating repair of UV radiation-induced 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	8-ohdg	132-167	8-oxoguanine DNA glycosylase	Homo sapiens	38-43
21113812-9	2011	GSE (50-100 mug/mL) attenuated TNF-alpha (20 ng/mL)-induced 8-OHdG production, THP-1 adhesion, the expression of IkappaB degradation, ICAM-1 and COX-2, and the production of PGE(2) in a dose-dependent manner.	8-ohdg	60-66	tumor necrosis factor	Homo sapiens	31-40
21696973-1	2011	In plants, 8-oxoguanine DNA glycosylase/lyase (OGG1) and formamidopyrimidine-DNA glycosylase (FPG) play similar roles within the base excision repair (BER) pathway involved in the removal of oxidized bases, e.g. 7,8-dihydro-8-oxoguanine (8-oxo-dG) and formamidopyrimidine (FAPy) lesions.	8-ohdg	238-246	formamidopyrimidine-DNA glycosylase	Medicago truncatula	57-92
21696973-1	2011	In plants, 8-oxoguanine DNA glycosylase/lyase (OGG1) and formamidopyrimidine-DNA glycosylase (FPG) play similar roles within the base excision repair (BER) pathway involved in the removal of oxidized bases, e.g. 7,8-dihydro-8-oxoguanine (8-oxo-dG) and formamidopyrimidine (FAPy) lesions.	8-ohdg	238-246	formamidopyrimidine-DNA glycosylase	Medicago truncatula	94-97
21684294-13	2011	We suggest that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations; elevated vitamin C and E levels in the Ostrava subjects decrease the levels of 8-oxodG.	8-ohdg	259-266	X-ray repair cross complementing 5	Homo sapiens	48-53
21718232-5	2011	Immunohistochemical signals of 8-OHdG were detected mainly in syncytiotrophoblasts and vascular endothelial cells, and co-localized with those for IDO.	8-ohdg	31-37	indoleamine 2,3-dioxygenase 1	Homo sapiens	147-150
21718232-6	2011	Furthermore, a significant inverse correlation was found between the IDO activity and 8-OhdG levels.	8-ohdg	86-92	indoleamine 2,3-dioxygenase 1	Homo sapiens	69-72
21415844-4	2011	Comparison of 8OHdG positive and negative PIH patients revealed that antenatal serum uric acid (UA) was significantly higher, gestational age at delivery was significantly lower and early onset PIH was more frequent in patients with 8OHdG positive staining in the placenta.	8-ohdg	233-238	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	194-197
21524692-6	2011	The number of terminal deoxynucleotidyl transferase (TdT)-mediated dNTP nick end labeling (TUNEL) and an oxidative stress marker, 8-hydroxy-2"-deoxyguanosine (8-OHdG) positive cells, were higher in HB-EGF KO mice than in WT mice.	8-ohdg	130-157	heparin-binding EGF-like growth factor	Mus musculus	198-204
21765606-3	2011	Mice treated with copper and peroxisome proliferator-activated receptor beta/delta agonist GW0742 had significantly less body weight loss, less serum alanine aminotransferase increase, less tumor necrosis factor alpha, macrophage inflammatory protein-2 and 8-hydroxy-2"-deoxyguanosine upregulation than copper treated mice.	8-ohdg	257-284	peroxisome proliferator activator receptor delta	Mus musculus	29-76
21691217-0	2011	Glycine N-methyltransferase affects urinary 1-hydroxypyrene and 8-hydroxy-2"-deoxyguanosine levels after PAH exposure.	8-ohdg	64-91	glycine N-methyltransferase	Homo sapiens	0-27
21691217-1	2011	OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs).	8-ohdg	178-205	glycine N-methyltransferase	Homo sapiens	102-129
21691217-1	2011	OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs).	8-ohdg	178-205	glycine N-methyltransferase	Homo sapiens	131-135
21691217-1	2011	OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs).	8-ohdg	207-213	glycine N-methyltransferase	Homo sapiens	102-129
21691217-1	2011	OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs).	8-ohdg	207-213	glycine N-methyltransferase	Homo sapiens	131-135
21691217-4	2011	RESULTS: Urinary 1-OHP level, GNMT STRP1 genotype, and worksite were significant predictors of urinary 8-OHdG levels after adjustments were made for covariates.	8-ohdg	103-109	glycine N-methyltransferase	Homo sapiens	30-34
21691217-5	2011	CONCLUSIONS: This study suggests that GNMT STRP1 could modulate urinary 1-OHP and 8-OHdG levels in coke-oven workers exposed to PAHs.	8-ohdg	82-88	glycine N-methyltransferase	Homo sapiens	38-42
21421019-7	2011	The expression levels of hMTH1 mRNA are highly correlated with hepatic levels of 8-oxo-dG and tail moment, suggesting that hMTH1 gene expression represents a molecular marker of oxidative DNA damage.	8-ohdg	81-89	nudix hydrolase 1	Homo sapiens	25-30
21421019-7	2011	The expression levels of hMTH1 mRNA are highly correlated with hepatic levels of 8-oxo-dG and tail moment, suggesting that hMTH1 gene expression represents a molecular marker of oxidative DNA damage.	8-ohdg	81-89	nudix hydrolase 1	Homo sapiens	123-128
21455019-7	2011	Therefore, AtRev1 possibly inserts dC opposite an AP site or 8-oxo-dG, which results in G to T transversions.	8-ohdg	61-69	DNA-directed DNA polymerase	Arabidopsis thaliana	11-17
21436346-9	2011	The statistically significant positive correlation between serum 8-OHdG and body mass index in the diabetic group indicates that obesity has an additive effect to increased BGL contributing to oxidative DNA damage.	8-ohdg	65-71	LPS responsive beige-like anchor protein	Homo sapiens	173-176
20875051-7	2011	To determine whether oxidation of dopamine by monoamine oxidase (MAO) is relevant in its genotoxicity, we inhibited MAO, which reduced the formation of micronuclei and of the oxidative DNA adduct 8-oxodG.	8-ohdg	196-203	monoamine oxidase A	Rattus norvegicus	65-68
20875051-7	2011	To determine whether oxidation of dopamine by monoamine oxidase (MAO) is relevant in its genotoxicity, we inhibited MAO, which reduced the formation of micronuclei and of the oxidative DNA adduct 8-oxodG.	8-ohdg	196-203	monoamine oxidase A	Rattus norvegicus	116-119
20488846-0	2011	Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes.	8-ohdg	49-55	glutathione S-transferase mu 1	Homo sapiens	91-96
21327395-4	2011	Tel administration resulted in the increased expression of liver peroxisome proliferator-activated receptor-gamma, carnitine palmitoyltransferase 1 and acyl-CoA oxidase 1 and decreased the number of 8-hydroxydeoxyguanosine-positive hepatocytes and the migration of macrophages positive for diastase-periodic-acid-Schiff.	8-ohdg	199-222	peroxisome proliferator-activated receptor gamma	Oryzias latipes	65-113
20488846-0	2011	Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes.	8-ohdg	49-55	glutathione S-transferase theta 1	Homo sapiens	98-103
20488846-0	2011	Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes.	8-ohdg	49-55	aldehyde dehydrogenase 2 family member	Homo sapiens	109-114
20488846-9	2011	This study shows that the relationship between urinary HA and 8-OHdG concentration is modified by genetic polymorphisms of some metabolizing enzymes such as GSTM1, GSTT1, and ALDH2.	8-ohdg	62-68	glutathione S-transferase mu 1	Homo sapiens	157-162
20488846-9	2011	This study shows that the relationship between urinary HA and 8-OHdG concentration is modified by genetic polymorphisms of some metabolizing enzymes such as GSTM1, GSTT1, and ALDH2.	8-ohdg	62-68	glutathione S-transferase theta 1	Homo sapiens	164-169
20488846-9	2011	This study shows that the relationship between urinary HA and 8-OHdG concentration is modified by genetic polymorphisms of some metabolizing enzymes such as GSTM1, GSTT1, and ALDH2.	8-ohdg	62-68	aldehyde dehydrogenase 2 family member	Homo sapiens	175-180
21104149-3	2011	The 8-oxoguanine glycosylase (hOGG1) and hMTH1, which have several polymorphisms, remove 8-OHdG from the nucleotide pool.	8-ohdg	89-95	8-oxoguanine DNA glycosylase	Homo sapiens	30-35
21104149-3	2011	The 8-oxoguanine glycosylase (hOGG1) and hMTH1, which have several polymorphisms, remove 8-OHdG from the nucleotide pool.	8-ohdg	89-95	nudix hydrolase 1	Homo sapiens	41-46
20339958-2	2011	Nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS), has been suggested to cause nitrative and oxidative stress, leading to the accumulation of 8-nitroguanine (8-NitroG) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) and the subsequent transversion mutation of DNA.	8-ohdg	192-219	nitric oxide synthase 2	Homo sapiens	31-62
21487522-11	2011	8OHdG associated with nuclear trx positivity (p=0.002), inversely with prx 1 (p=0.025) and with keap1 (p=0.020).	8-ohdg	0-5	thioredoxin	Homo sapiens	30-33
21178785-11	2011	Furthermore, the CC genotype of the c.891C&gt;T polymorphism in the GPX1 gene was associated with higher values of 8-oxo-dG and GPX activity levels as compared to those for the CT-TT genotype.	8-ohdg	115-123	glutathione peroxidase 1	Homo sapiens	68-72
20339958-2	2011	Nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS), has been suggested to cause nitrative and oxidative stress, leading to the accumulation of 8-nitroguanine (8-NitroG) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) and the subsequent transversion mutation of DNA.	8-ohdg	192-219	nitric oxide synthase 2	Homo sapiens	64-68
20339958-2	2011	Nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS), has been suggested to cause nitrative and oxidative stress, leading to the accumulation of 8-nitroguanine (8-NitroG) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) and the subsequent transversion mutation of DNA.	8-ohdg	221-227	nitric oxide synthase 2	Homo sapiens	31-62
21487522-11	2011	8OHdG associated with nuclear trx positivity (p=0.002), inversely with prx 1 (p=0.025) and with keap1 (p=0.020).	8-ohdg	0-5	peroxiredoxin 1	Homo sapiens	71-76
20339958-2	2011	Nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS), has been suggested to cause nitrative and oxidative stress, leading to the accumulation of 8-nitroguanine (8-NitroG) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) and the subsequent transversion mutation of DNA.	8-ohdg	221-227	nitric oxide synthase 2	Homo sapiens	64-68
21487522-11	2011	8OHdG associated with nuclear trx positivity (p=0.002), inversely with prx 1 (p=0.025) and with keap1 (p=0.020).	8-ohdg	0-5	kelch like ECH associated protein 1	Homo sapiens	96-101
20813770-10	2011	Klotho expression was correlated with angiotensinogen and renin expression, tubulointerstitial fibrosis score and urinary 8-OHdG excretion.	8-ohdg	122-128	klotho	Mus musculus	0-6
21104990-6	2011	Fibroblasts from Ogg1 KO mice accumulated 8-oxodG following acute exposure to the renal carcinogen potassium bromate (KBrO(3) ; 2.0 mM) but did not accumulate 8-oxodG following exposure to 125 mM MeOH 6 h post-treatment.	8-ohdg	42-49	8-oxoguanine DNA-glycosylase 1	Mus musculus	17-21
21104990-7	2011	Ogg1 KO mice accumulated 8-oxodG in bone marrow and spleen with age but not following exposure to MeOH.	8-ohdg	25-32	8-oxoguanine DNA-glycosylase 1	Mus musculus	0-4
21609530-8	2011	CONCLUSION: Combined mixed-tocopherols + EPA use enhanced the inhibiting effects on the secretion of 8-OHDG and IL-6 in oxLDL stimulated HUVECs which might be linked with increased SOD activity and reduced p-PKC activity.	8-ohdg	101-107	superoxide dismutase 1	Homo sapiens	181-184
21720543-5	2011	The superoxide production is associated with oxidative DNA damage as indicated by colocalization of the dihydroethidium (DHE) signal with 8-OHdG fluorescence in SOD2(-/+) mice.	8-ohdg	138-144	superoxide dismutase 2, mitochondrial	Mus musculus	161-165
20189611-7	2011	AST-120 treatment (6 g/d), but not control treatment, for 12 months significantly reduced IL-6, proteinuria, and urinary excretion levels of L-FABP and 8-OHdG, and inhibited the increase in serum creatinine in CRF patients.	8-ohdg	152-158	solute carrier family 17 member 5	Homo sapiens	0-3
21145906-3	2011	The base excision repair (BER) pathway is the major mechanism for the repair of oxidative DNA base lesions, and we have shown an up-regulation of 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase involved in the removal of 8-hydroxy-2"-deoxyguanosine (8-OHdG) adducts, following aniline exposure.	8-ohdg	235-262	8-oxoguanine DNA glycosylase	Rattus norvegicus	146-172
21145906-3	2011	The base excision repair (BER) pathway is the major mechanism for the repair of oxidative DNA base lesions, and we have shown an up-regulation of 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase involved in the removal of 8-hydroxy-2"-deoxyguanosine (8-OHdG) adducts, following aniline exposure.	8-ohdg	235-262	8-oxoguanine DNA glycosylase	Rattus norvegicus	174-178
21145906-3	2011	The base excision repair (BER) pathway is the major mechanism for the repair of oxidative DNA base lesions, and we have shown an up-regulation of 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase involved in the removal of 8-hydroxy-2"-deoxyguanosine (8-OHdG) adducts, following aniline exposure.	8-ohdg	264-270	8-oxoguanine DNA glycosylase	Rattus norvegicus	146-172
21145906-3	2011	The base excision repair (BER) pathway is the major mechanism for the repair of oxidative DNA base lesions, and we have shown an up-regulation of 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase involved in the removal of 8-hydroxy-2"-deoxyguanosine (8-OHdG) adducts, following aniline exposure.	8-ohdg	264-270	8-oxoguanine DNA glycosylase	Rattus norvegicus	174-178
20189611-8	2011	In univariate analyses, L-FABP levels were correlated with age, proteinuria, 8-OHdG, and IL-6.	8-ohdg	77-83	fatty acid binding protein 1	Homo sapiens	24-30
20189611-9	2011	In multiple stepwise regression analysis, proteinuria and urinary 8-OHdG levels were independently related to L-FABP levels (R2 = 0.605).	8-ohdg	66-72	fatty acid binding protein 1	Homo sapiens	110-116
21114981-10	2011	These results indicate that 8-oxo-dG can inhibit allergy-induced inflammation and remodeling in airway and lung tissues through Rac inactivation.	8-ohdg	28-36	thymoma viral proto-oncogene 1	Mus musculus	128-131
20951653-3	2011	7,8-Dihydro-8-oxogaunine (8-oxodG) is one of the most abundant oxidative guanine lesions, and 8-oxoguanine DNA glycosylase (OGG1) is involved in its removal.	8-ohdg	26-33	8-oxoguanine DNA glycosylase	Homo sapiens	124-128
21112374-0	2011	AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population.	8-ohdg	59-65	mutY DNA glycosylase	Homo sapiens	24-29
20950637-5	2011	These results were corroborated in DNA repair-deficient oxoguanine glycosylase 1 (Ogg1) knockout (KO) mice, which accumulated 8-oxodG in lung, kidney and liver with age, but exhibited no increase following MeOH, despite a 2-fold increase in renal 8-oxodG in Ogg1 KO mice following treatment with a ROS-initiating positive control, the renal carcinogen potassium bromate (KBrO3; 100 mg/kg ip).	8-ohdg	126-133	8-oxoguanine DNA-glycosylase 1	Mus musculus	82-86
20950637-5	2011	These results were corroborated in DNA repair-deficient oxoguanine glycosylase 1 (Ogg1) knockout (KO) mice, which accumulated 8-oxodG in lung, kidney and liver with age, but exhibited no increase following MeOH, despite a 2-fold increase in renal 8-oxodG in Ogg1 KO mice following treatment with a ROS-initiating positive control, the renal carcinogen potassium bromate (KBrO3; 100 mg/kg ip).	8-ohdg	247-254	8-oxoguanine DNA-glycosylase 1	Mus musculus	82-86
21114981-1	2011	We previously reported that 8-oxo-2"-deoxyguanosine (8-oxo-dG) suppressed airway hyperresponsiveness and allergy-associated immune responses in ovalbumin-induced allergic mice by inactivating Rac.	8-ohdg	28-51	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	144-153
21114981-1	2011	We previously reported that 8-oxo-2"-deoxyguanosine (8-oxo-dG) suppressed airway hyperresponsiveness and allergy-associated immune responses in ovalbumin-induced allergic mice by inactivating Rac.	8-ohdg	28-51	thymoma viral proto-oncogene 1	Mus musculus	192-195
21114981-1	2011	We previously reported that 8-oxo-2"-deoxyguanosine (8-oxo-dG) suppressed airway hyperresponsiveness and allergy-associated immune responses in ovalbumin-induced allergic mice by inactivating Rac.	8-ohdg	53-61	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	144-153
21114981-1	2011	We previously reported that 8-oxo-2"-deoxyguanosine (8-oxo-dG) suppressed airway hyperresponsiveness and allergy-associated immune responses in ovalbumin-induced allergic mice by inactivating Rac.	8-ohdg	53-61	thymoma viral proto-oncogene 1	Mus musculus	192-195
21114981-9	2011	However, 8-oxo-dG suppressed all these inflammatory and tissue remodeling signs as well as activation of Rac1 and 2.	8-ohdg	9-17	Rac family small GTPase 1	Mus musculus	105-115
20951653-6	2011	We also showed that the 8-oxodG-incision activity of OGG1 is similar in telomeric and non-telomeric double-stranded substrates.	8-ohdg	24-31	8-oxoguanine DNA glycosylase	Homo sapiens	53-57
20951653-8	2011	Yet, 8-oxodG in some telomere structures (e.g., fork-opening, 3"-overhang, and D-loop) were less effectively excised by OGG1, depending upon its position in these substrates.	8-ohdg	5-12	8-oxoguanine DNA glycosylase	Homo sapiens	120-124
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	NADPH oxidase 1	Mus musculus	81-85
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	NADPH oxidase organizer 1	Mus musculus	87-92
20816670-7	2011	Similarly, 8-OHdG attenuated hypoxia-induced angiogenesis and platelet endothelial cell adhesion molecule-1 (PECAM-1), COX-2, iNOS, IL-8, and VEGF expressions in HUVEC cells.	8-ohdg	11-17	nitric oxide synthase 2, inducible	Mus musculus	126-130
20816670-7	2011	Similarly, 8-OHdG attenuated hypoxia-induced angiogenesis and platelet endothelial cell adhesion molecule-1 (PECAM-1), COX-2, iNOS, IL-8, and VEGF expressions in HUVEC cells.	8-ohdg	11-17	chemokine (C-X-C motif) ligand 15	Mus musculus	132-136
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	NADPH oxidase activator 1	Mus musculus	98-103
20816670-7	2011	Similarly, 8-OHdG attenuated hypoxia-induced angiogenesis and platelet endothelial cell adhesion molecule-1 (PECAM-1), COX-2, iNOS, IL-8, and VEGF expressions in HUVEC cells.	8-ohdg	11-17	vascular endothelial growth factor A	Mus musculus	142-146
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	cytochrome c oxidase II, mitochondrial	Mus musculus	195-200
20816670-8	2011	At transcriptional level, 8-OHdG inhibited the nuclear translocation of NF-kappaB, inhibitory kappaB kinase (IKK) beta kinase activation, and decreased phospho-IkappaBalpha levels.	8-ohdg	26-32	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	160-172
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	nitric oxide synthase 2, inducible	Mus musculus	202-206
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	interleukin 1 beta	Mus musculus	208-216
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	interleukin 6	Mus musculus	222-226
20816670-7	2011	Similarly, 8-OHdG attenuated hypoxia-induced angiogenesis and platelet endothelial cell adhesion molecule-1 (PECAM-1), COX-2, iNOS, IL-8, and VEGF expressions in HUVEC cells.	8-ohdg	11-17	platelet/endothelial cell adhesion molecule 1	Mus musculus	62-107
20816670-7	2011	Similarly, 8-OHdG attenuated hypoxia-induced angiogenesis and platelet endothelial cell adhesion molecule-1 (PECAM-1), COX-2, iNOS, IL-8, and VEGF expressions in HUVEC cells.	8-ohdg	11-17	platelet/endothelial cell adhesion molecule 1	Mus musculus	109-116
20816670-7	2011	Similarly, 8-OHdG attenuated hypoxia-induced angiogenesis and platelet endothelial cell adhesion molecule-1 (PECAM-1), COX-2, iNOS, IL-8, and VEGF expressions in HUVEC cells.	8-ohdg	11-17	cytochrome c oxidase II, mitochondrial	Mus musculus	119-124
21519150-9	2011	Nuclear staining of 8-hydroxydeoxyguanosine was also increased in CRP/DM compared with Wt/DM.	8-ohdg	20-43	C-reactive protein	Homo sapiens	66-69
21322094-2	2011	A frequently occurring mutagenic base lesion produced by ROS is 8-oxo deoxyguanine (8-oxo dG) and the major enzyme for repair of 8-oxo dG is 8-oxoguanine-DNA glycosylase 1 (OGG1).	8-ohdg	84-92	8-oxoguanine DNA glycosylase	Homo sapiens	141-171
21921413-10	2011	Moreover, urinary 8-OHdG and L-FABP levels at baseline (13.5+-5.1 and 41.7+-26.1 ng/mgCr, respectively) decreased significantly at 6 months (11.5+-4.0 and 26.9+-13.4 ng/mgCr, respectively), and there was a significant correlation (r = 0.48, p &lt; 0.01).	8-ohdg	18-24	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	84-88
21921413-10	2011	Moreover, urinary 8-OHdG and L-FABP levels at baseline (13.5+-5.1 and 41.7+-26.1 ng/mgCr, respectively) decreased significantly at 6 months (11.5+-4.0 and 26.9+-13.4 ng/mgCr, respectively), and there was a significant correlation (r = 0.48, p &lt; 0.01).	8-ohdg	18-24	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	169-173
22181980-6	2011	This study aimed to elucidate the role of tea against arsenic-induced formation of 8-hydroxy-2"-deoxyguanosine (8OHdG) and arsenic-suppressed DNA repair in Swiss albino mice.	8-ohdg	83-110	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	42-45
22181980-6	2011	This study aimed to elucidate the role of tea against arsenic-induced formation of 8-hydroxy-2"-deoxyguanosine (8OHdG) and arsenic-suppressed DNA repair in Swiss albino mice.	8-ohdg	112-117	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	42-45
21322094-2	2011	A frequently occurring mutagenic base lesion produced by ROS is 8-oxo deoxyguanine (8-oxo dG) and the major enzyme for repair of 8-oxo dG is 8-oxoguanine-DNA glycosylase 1 (OGG1).	8-ohdg	84-92	8-oxoguanine DNA glycosylase	Homo sapiens	173-177
21322094-2	2011	A frequently occurring mutagenic base lesion produced by ROS is 8-oxo deoxyguanine (8-oxo dG) and the major enzyme for repair of 8-oxo dG is 8-oxoguanine-DNA glycosylase 1 (OGG1).	8-ohdg	129-137	8-oxoguanine DNA glycosylase	Homo sapiens	141-171
21322094-2	2011	A frequently occurring mutagenic base lesion produced by ROS is 8-oxo deoxyguanine (8-oxo dG) and the major enzyme for repair of 8-oxo dG is 8-oxoguanine-DNA glycosylase 1 (OGG1).	8-ohdg	129-137	8-oxoguanine DNA glycosylase	Homo sapiens	173-177
21541882-5	2011	In response to oxidative DNA base damage, 8-oxoguanine DNA glycosylase 1 (OGG1) plays a vital role in repair of 8-hydroxy-2"-deoxyguanosine (8-OhdG) via the base-excision repair (BER) process.	8-ohdg	112-139	8-oxoguanine DNA glycosylase	Homo sapiens	42-72
21541882-5	2011	In response to oxidative DNA base damage, 8-oxoguanine DNA glycosylase 1 (OGG1) plays a vital role in repair of 8-hydroxy-2"-deoxyguanosine (8-OhdG) via the base-excision repair (BER) process.	8-ohdg	112-139	8-oxoguanine DNA glycosylase	Homo sapiens	74-78
21709422-7	2011	Urinary excretion of 8-OHdG was also significantly lower in the OLM and OLM+Ang II groups compared to the OLM+PD group.	8-ohdg	21-27	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	76-79
20870805-9	2010	EPO also ameliorated oxidative stress and myocardial injury, as assessed by plasma 8-hydroxydeoxyguanosine and troponin-T, respectively.	8-ohdg	83-106	erythropoietin	Canis lupus familiaris	0-3
21541882-5	2011	In response to oxidative DNA base damage, 8-oxoguanine DNA glycosylase 1 (OGG1) plays a vital role in repair of 8-hydroxy-2"-deoxyguanosine (8-OhdG) via the base-excision repair (BER) process.	8-ohdg	141-147	8-oxoguanine DNA glycosylase	Homo sapiens	42-72
21541882-5	2011	In response to oxidative DNA base damage, 8-oxoguanine DNA glycosylase 1 (OGG1) plays a vital role in repair of 8-hydroxy-2"-deoxyguanosine (8-OhdG) via the base-excision repair (BER) process.	8-ohdg	141-147	8-oxoguanine DNA glycosylase	Homo sapiens	74-78
21541882-7	2011	Suppression of 8-OhdG formation by triphlorethol-A was related to enhanced OGG1 protein expression.	8-ohdg	15-21	8-oxoguanine DNA glycosylase	Homo sapiens	75-79
20735435-4	2010	Time-dependent and statistically significant increases in 8-OHdG levels were observed in the PBO treatment group along with significant increases in proliferating cell nuclear antigen (PCNA)-positive hepatocytes at 4 weeks, while no increase in 8-OHdG levels was found in PhB-treated rats.	8-ohdg	58-64	proliferating cell nuclear antigen	Rattus norvegicus	185-189
21060073-8	2010	The level of oxidative stress after I/R, as evaluated by anti-8-hydroxydeoxyguanosine staining, was negatively regulated by Sirt1.	8-ohdg	62-85	sirtuin 1	Mus musculus	124-129
20735435-7	2010	CYP 1A1 and 1A2 induction may be responsible for elevated levels of 8-OHdG in PBO-treated rats.	8-ohdg	68-74	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-15
20833163-5	2010	Chromogranin A was increased in uremic, peritoneal and haemodialysis patients (p&lt;0.01), showing a positive correlation to 8-OHdG (p&lt;0.01).	8-ohdg	125-131	chromogranin A	Homo sapiens	0-14
20660821-7	2010	Daily urinary excretion of 8-hydroxy-2"-deoxyguanosine, a parameter of oxidative stress, and dihydroethidium-positive spots, indicating superoxide production in the myocardium, were markedly increased in Ang II-treated HCII(+/-) mice compared to those in HCII(+/+) mice.	8-ohdg	27-54	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	204-210
20719976-8	2010	These protective effects of Cygb were associated with a decrease in nitrotyrosine deposition in the kidney and urinary 8-hydroxy-2"-deoxyguanosine (8-OHdG) excretion as a marker of oxidative stress.	8-ohdg	119-146	cytoglobin	Rattus norvegicus	28-32
20719976-8	2010	These protective effects of Cygb were associated with a decrease in nitrotyrosine deposition in the kidney and urinary 8-hydroxy-2"-deoxyguanosine (8-OHdG) excretion as a marker of oxidative stress.	8-ohdg	148-154	cytoglobin	Rattus norvegicus	28-32
20854248-4	2010	Plasmin and t-PA damaged rat brain with the most prominent injury in t-PA group on 4-HNE, HEL, and 8-OHdG immunostainings.	8-ohdg	99-105	plasminogen activator, tissue type	Rattus norvegicus	12-16
20854248-4	2010	Plasmin and t-PA damaged rat brain with the most prominent injury in t-PA group on 4-HNE, HEL, and 8-OHdG immunostainings.	8-ohdg	99-105	plasminogen activator, tissue type	Rattus norvegicus	69-73
20724227-2	2010	MUTYH is a DNA glycosylase that removes adenine (A) misinserted opposite 8-oxo-7,8-dihydro-2"-deoxyguanosine (OG).	8-ohdg	73-108	mutY DNA glycosylase	Homo sapiens	0-5
20667409-2	2010	In humans, 8-hydroxydeoxyguanosine is repaired by the enzyme 8-oxoguanine glycosylase I (hOGG1).	8-ohdg	11-34	8-oxoguanine DNA glycosylase	Homo sapiens	89-94
20830300-6	2010	Oxidative stress damage in the hippocampal CA1 after ischemia/reperfusion was also significantly attenuated by NSC23766 treatment, as evidenced by a marked attenuation of immunostaining for the oxidative stress damage markers, 4-HNE, 8-OHdG and H2AX at 24 h in the hippocampal CA1 region following cerebral ischemia.	8-ohdg	234-240	carbonic anhydrase 1	Rattus norvegicus	43-46
20847286-7	2010	A marker of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine, colocalized to mitochondria, indicating that the mitochondrial genome is the specific target of oxidative stress in FECD.	8-ohdg	34-61	collagen type VIII alpha 2 chain	Homo sapiens	179-183
20837600-4	2010	A complete deficiency in tuberin is associated with loss of AP4 and OGG1 expression in kidney tumour from Eker rats and the accumulation of significant levels of 8-oxo-deoxyguanosine.	8-ohdg	162-182	TSC complex subunit 2	Rattus norvegicus	25-32
19084291-4	2010	8-OHdG co-localized with the mitochondrial enzyme superoxide dismutase (MnSOD), suggesting damage to mtDNA.	8-ohdg	0-6	superoxide dismutase 2	Homo sapiens	29-70
19084291-4	2010	8-OHdG co-localized with the mitochondrial enzyme superoxide dismutase (MnSOD), suggesting damage to mtDNA.	8-ohdg	0-6	superoxide dismutase 2	Homo sapiens	72-77
20660821-7	2010	Daily urinary excretion of 8-hydroxy-2"-deoxyguanosine, a parameter of oxidative stress, and dihydroethidium-positive spots, indicating superoxide production in the myocardium, were markedly increased in Ang II-treated HCII(+/-) mice compared to those in HCII(+/+) mice.	8-ohdg	27-54	serine (or cysteine) peptidase inhibitor, clade D, member 1	Mus musculus	219-223
20562008-1	2010	hOGG1 protein excises the 8-hydroxy-2"-deoxyguanine (8-OHdG) which is associated with type 2 diabetes mellitus (T2DM).	8-ohdg	53-59	8-oxoguanine DNA glycosylase	Homo sapiens	0-5
20537331-9	2010	BMP-2 serum levels were inversely associated with eGFR (r=-0.3; p=0.01) and directly correlated with 8-OHdG serum concentrations (r=-0.3; p=0.03).	8-ohdg	101-107	bone morphogenetic protein 2	Homo sapiens	0-5
20718982-4	2010	METHODS: In the current study we elucidate the association between plasma levels of 8-OHdG and the OGG1 repair capacity.	8-ohdg	84-90	8-oxoguanine DNA glycosylase	Homo sapiens	99-103
20143344-7	2010	Since OGG1 is a specific repair enzyme for 8-oxo-deoxyguanosine (8-oxo-dG), these findings indicated that 8-oxo-dG was involved.	8-ohdg	43-63	8-oxoguanine DNA glycosylase	Homo sapiens	6-10
20621990-5	2010	A higher 8-OHdG concentration was significantly associated with lower global cognitive scores, after adjustment for age, education, status of the gene for apolipoprotein E (APOE), and other covariates (P(trend) = 0.01).	8-ohdg	9-15	apolipoprotein E	Homo sapiens	155-171
20458166-4	2010	Increased 8-hydroxy-2"-deoxyguanosine, an adduct indicating oxidative damage, was found in liver and prostate tissues at 2 and 12 mo Sod1 (+/-) mice compared to controls.	8-ohdg	10-37	superoxide dismutase 1, soluble	Mus musculus	133-137
20334614-8	2010	Expression of VEGF-R2 was identified to be co-localized with 8-OHdG after TBI.	8-ohdg	61-67	kinase insert domain protein receptor	Mus musculus	14-21
20621990-5	2010	A higher 8-OHdG concentration was significantly associated with lower global cognitive scores, after adjustment for age, education, status of the gene for apolipoprotein E (APOE), and other covariates (P(trend) = 0.01).	8-ohdg	9-15	apolipoprotein E	Homo sapiens	173-177
20562737-9	2010	There was a strong correlation between KLOTHO expression and urinary 8-OHdG excretion (r=-0.893; P&lt;0.001).	8-ohdg	69-75	klotho	Mus musculus	39-45
20236686-0	2010	The close correlation between 8-hydroxy-2"-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancer.	8-ohdg	30-57	epidermal growth factor receptor	Homo sapiens	62-94
20236686-6	2010	In non-small cell lung cancer patients, nuclear 8-hydroxy-2"-deoxyguanosine expression was strongly associated with these epidermal growth factor receptor mutations.	8-ohdg	48-75	epidermal growth factor receptor	Homo sapiens	122-154
20236686-9	2010	Thus, activating mutations of the epidermal growth factor receptor gene in non-small cell lung cancer were closely associated with a decrease in the damage repair process for 8-hydroxy-2"-deoxyguanosine in oxidized DNA.	8-ohdg	175-202	epidermal growth factor receptor	Homo sapiens	34-66
20143344-7	2010	Since OGG1 is a specific repair enzyme for 8-oxo-deoxyguanosine (8-oxo-dG), these findings indicated that 8-oxo-dG was involved.	8-ohdg	65-73	8-oxoguanine DNA glycosylase	Homo sapiens	6-10
20143344-7	2010	Since OGG1 is a specific repair enzyme for 8-oxo-deoxyguanosine (8-oxo-dG), these findings indicated that 8-oxo-dG was involved.	8-ohdg	106-114	8-oxoguanine DNA glycosylase	Homo sapiens	6-10
19844955-9	2010	The current results demonstrate a lag in excretion of urinary 8-OHdG relative to 1-OHP and 3-PHBaP after dietary PAH exposure.	8-ohdg	62-68	phenylalanine hydroxylase	Homo sapiens	113-116
19817625-0	2010	Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation.	8-ohdg	63-69	NADPH oxidase 4	Mus musculus	0-5
20072135-6	2010	Ang1 prevented H(2)O(2)-induced increases in damage to DNA (8-hydroxy-2"-deoxyguanosine) and proteins (nitrotyrosinylation).	8-ohdg	60-87	angiopoietin 1	Homo sapiens	0-4
20351271-3	2010	Elevated GLS2 facilitates glutamine metabolism and lowers intracellular reactive oxygen species (ROS) levels, resulting in an overall decrease in DNA oxidation as determined by measurement of 8-OH-dG content in both normal and stressed cells.	8-ohdg	192-199	glutaminase 2	Homo sapiens	9-13
19844955-10	2010	These relationships highlight the importance of sampling time when assessing PAH-related DNA lesions through urinary 8-OHdG.	8-ohdg	117-123	phenylalanine hydroxylase	Homo sapiens	77-80
20067818-9	2010	These data suggest that ROS mediated MAPK activation is involved in the molecular mechanisms of BrO(3)(-)-induced cell cycle arrest, which occurs independently of 8-OH-dG production.	8-ohdg	163-170	mitogen-activated protein kinase 3	Homo sapiens	37-41
23105898-8	2010	The urinary 8-OHdG was independently correlated with serum TAS.	8-ohdg	12-18	THAS	Homo sapiens	59-62
23105898-9	2010	Decreased TAS levels, which reflect to increased oxidative stress, may be the reason of increased urinary 8-OHdG in South Indian hypertensive patients.	8-ohdg	106-112	THAS	Homo sapiens	10-13
20167745-8	2010	Significant associations were noted between plasma concentrations of the DYS14 gene and the levels of urinary 8-OHdG and plasma 8-isoprostane, suggesting an association between the breakdown of syncytiotrophoblast and maternal oxidative stress during pregnancy.	8-ohdg	110-116	testis specific protein Y-linked 1	Homo sapiens	73-78
20019361-12	2010	IL-1beta and TNFalpha showed a significant correlation with 8-OHdG-stained cell counts.	8-ohdg	60-66	interleukin 1 beta	Homo sapiens	0-8
20019361-12	2010	IL-1beta and TNFalpha showed a significant correlation with 8-OHdG-stained cell counts.	8-ohdg	60-66	tumor necrosis factor	Homo sapiens	13-21
20036649-12	2010	In school children, PAH levels also correlated significantly with 8-OHdG levels, DNA strand breaks and DNA repair capacity.	8-ohdg	66-72	phenylalanine hydroxylase	Homo sapiens	20-23
20042377-2	2010	To assess the location and intracellular activity of the OGG1 protein in response to oxidative stress, we have utilised a fluorescence-quench molecular beacon switch containing a 8-oxo-dG:C base pair and a fluorescent and quencher molecule at opposite ends of a hairpin oligonucleotide.	8-ohdg	179-187	8-oxoguanine DNA glycosylase	Homo sapiens	57-61
20018843-11	2010	UVB induced an increase in cutaneous levels of cyclobutane pyrimidine dimers and 8-hydroxy-2"-deoxyguanosine, both of which were suppressed in transgenic mice expressing HSP70.	8-ohdg	81-108	heat shock protein 1B	Mus musculus	170-175
19932167-1	2010	We describe a common mutation of the MYH gene, which is involved in the repair of oxidative damage to DNA, and its relationship to age, levels of 8-OHdG, and circulating levels of interleukin-1.	8-ohdg	146-152	mutY DNA glycosylase	Homo sapiens	37-40
19932167-5	2010	Because the MYH gene is involved in DNA repair we assessed whether homozygous carriage of this gene was associated with increased levels of 8-OHdG in the leukocytic DNA of carriers.	8-ohdg	140-146	mutY DNA glycosylase	Homo sapiens	12-15
19853637-3	2010	However, previous results from this laboratory demonstrated huge increases in tail intensity by modifying the method to include incubation with either human 8-oxodeoxyguanosine DNA glycosylase-1 (hOGG1) or bacterial formamidopyrimidine DNA glycosylase (FPG) indicating that, as expected, significant amounts of 8-oxodeoxyguanosine (8-OHdG) were induced.	8-ohdg	157-176	8-oxoguanine DNA glycosylase	Homo sapiens	196-201
20095848-4	2010	Importantly, HIF1alpha levels paralleled oxidative stress (8-OHdG), tissue hypoxia (pimonidazole and CA IX), and macrophage accumulation consistent with inflammatory response.	8-ohdg	59-65	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	13-22
20124500-7	2010	There was a marked association between CYP2E1 expression and DNA oxidation (8-oxo-dG) in areas of centrilobular hepatocyte necrosis seen after a single dose.	8-ohdg	76-84	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	39-45
19853637-3	2010	However, previous results from this laboratory demonstrated huge increases in tail intensity by modifying the method to include incubation with either human 8-oxodeoxyguanosine DNA glycosylase-1 (hOGG1) or bacterial formamidopyrimidine DNA glycosylase (FPG) indicating that, as expected, significant amounts of 8-oxodeoxyguanosine (8-OHdG) were induced.	8-ohdg	332-338	8-oxoguanine DNA glycosylase	Homo sapiens	196-201
19734539-0	2009	Telomeric D-loops containing 8-oxo-2"-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1.	8-ohdg	29-52	protection of telomeres 1	Homo sapiens	135-139
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	DNA methyltransferase 1	Homo sapiens	155-160
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	DNA methyltransferase 3 beta	Homo sapiens	162-168
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	thioredoxin reductase 1	Homo sapiens	171-194
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	thioredoxin reductase 1	Homo sapiens	196-202
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	thioredoxin reductase 2	Homo sapiens	211-217
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	glutaredoxin	Homo sapiens	223-235
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	glutaredoxin	Homo sapiens	237-241
20040097-4	2009	Downregulation of tuberin results in a marked decrease of OGG1 and accumulation of oxidative DNA damage, (8-oxodG) in cultured cells.	8-ohdg	106-113	TSC complex subunit 2	Homo sapiens	18-25
20040097-6	2009	Deficiency in tuberin results in decreased OGG1 and NF-YA protein expression and increased 8-oxodG in kidney tumor from TSC patients.	8-ohdg	91-98	TSC complex subunit 2	Homo sapiens	14-21
19845673-1	2009	BACKGROUND AND PURPOSE: Earlier we reported that 7,8-dihydro-8-oxo-deoxyguanosine (8-oxo-dG), an oxidatively modified guanine nucleoside, exerted anti-inflammatory activity through inactivation of the GTP binding protein, Rac.	8-ohdg	83-91	thymoma viral proto-oncogene 1	Mus musculus	222-225
19845673-2	2009	In the present study, the effects of 8-oxo-dG were investigated on responses to antigen challenge in sensitized mice, as Rac is also involved at several steps of the immune process including antigen-induced release of mediators from mast cells.	8-ohdg	37-45	thymoma viral proto-oncogene 1	Mus musculus	121-124
19845673-7	2009	Furthermore, 8-oxo-dG suppressed allergy-associated immune responses, such as raised anti- ovalbumin IgE antibody in serum, increased expression of CD40 and CD40 ligand in lung, increased interleukin-4, -5, -13, interferon-gamma and tumour necrosis factor-alpha in BALF and mRNA levels of these cytokines in BALF cells, dose-dependently.	8-ohdg	13-21	CD40 antigen	Mus musculus	148-152
19845673-7	2009	Furthermore, 8-oxo-dG suppressed allergy-associated immune responses, such as raised anti- ovalbumin IgE antibody in serum, increased expression of CD40 and CD40 ligand in lung, increased interleukin-4, -5, -13, interferon-gamma and tumour necrosis factor-alpha in BALF and mRNA levels of these cytokines in BALF cells, dose-dependently.	8-ohdg	13-21	CD40 antigen	Mus musculus	157-161
19845673-7	2009	Furthermore, 8-oxo-dG suppressed allergy-associated immune responses, such as raised anti- ovalbumin IgE antibody in serum, increased expression of CD40 and CD40 ligand in lung, increased interleukin-4, -5, -13, interferon-gamma and tumour necrosis factor-alpha in BALF and mRNA levels of these cytokines in BALF cells, dose-dependently.	8-ohdg	13-21	interleukin 4	Mus musculus	188-205
19845673-7	2009	Furthermore, 8-oxo-dG suppressed allergy-associated immune responses, such as raised anti- ovalbumin IgE antibody in serum, increased expression of CD40 and CD40 ligand in lung, increased interleukin-4, -5, -13, interferon-gamma and tumour necrosis factor-alpha in BALF and mRNA levels of these cytokines in BALF cells, dose-dependently.	8-ohdg	13-21	interferon gamma	Mus musculus	212-261
19845673-9	2009	Finally, 8-oxo-dG, but not 8-oxo-guanine, inhibited the increased Rac activity in sensitized and challenged mice.	8-ohdg	9-17	thymoma viral proto-oncogene 1	Mus musculus	66-69
19845673-10	2009	CONCLUSION AND IMPLICATIONS: 8-Oxo-dG had anti-allergic actions that might be mediated by Rac inactivation.	8-ohdg	29-37	thymoma viral proto-oncogene 1	Mus musculus	90-93
19905978-5	2009	In the CAD group, 8-OHdG and biopyrrins levels increased with the severity of the New York Heart Association (NYHA) functional class and log BNP levels correlated with 8-OHdG and biopyrrins levels.	8-ohdg	168-174	natriuretic peptide B	Homo sapiens	141-144
19737572-4	2009	Using formamido-pyrimidine glycosylase (FPG) comet assay, we found that 1-h DHP (10nM) treatment before X-irradiation considerably reduced the initial level of FPG-recognized DNA base damage, which was consistent with decreased 8-oxo-7,8-dihydro-2"-deoxyguanosine content and mutation frequency lowered by about 40%.	8-ohdg	228-263	dihydropyrimidinase	Homo sapiens	76-79
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	76-112
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	114-119
19896490-9	2010	A genetic influence on 8-oxodG concentrations was seen for polymorphisms in apurinic/apyrimidinic endonuclease 1 (APEX1), DNA-methyltransferases 1 and 3b (DNMT1, DNMT3B), thioredoxin reductase 1 (TXNRD1) and 2 (TXNRD2) and glutaredoxin (GLRX).	8-ohdg	23-30	DNA methyltransferase 1	Homo sapiens	122-153
20595787-9	2010	3) High-sensitive c-reactive protein in serum and heart rate variability (HRV) were useful biomarkers of not only exposure to ultrafine particles but disorder of cardiovascular disease, 8-hydroxydeoxyguanosine in urine is a biomarker of acute lung injury by welder fume, and VEGF and CA15-3 are highly sensitive and specific biomarkers of pulmonary fibrosis.	8-ohdg	186-209	C-reactive protein	Homo sapiens	18-36
20595787-9	2010	3) High-sensitive c-reactive protein in serum and heart rate variability (HRV) were useful biomarkers of not only exposure to ultrafine particles but disorder of cardiovascular disease, 8-hydroxydeoxyguanosine in urine is a biomarker of acute lung injury by welder fume, and VEGF and CA15-3 are highly sensitive and specific biomarkers of pulmonary fibrosis.	8-ohdg	186-209	vascular endothelial growth factor A	Homo sapiens	275-279
20595787-9	2010	3) High-sensitive c-reactive protein in serum and heart rate variability (HRV) were useful biomarkers of not only exposure to ultrafine particles but disorder of cardiovascular disease, 8-hydroxydeoxyguanosine in urine is a biomarker of acute lung injury by welder fume, and VEGF and CA15-3 are highly sensitive and specific biomarkers of pulmonary fibrosis.	8-ohdg	186-209	mucin 1, cell surface associated	Homo sapiens	284-290
19659742-4	2009	Pretreatment of melanocytes with alpha-melanocortin (alpha-MSH) reduced the UV-induced generation of 7,8-dihydro-8-oxyguanine (8-oxodG), a major form of oxidative DNA damage.	8-ohdg	127-134	proopiomelanocortin	Homo sapiens	53-62
19659742-6	2009	The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.	8-ohdg	27-34	proopiomelanocortin	Homo sapiens	14-23
19659742-6	2009	The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.	8-ohdg	27-34	melanocortin 1 receptor	Homo sapiens	79-102
19659742-6	2009	The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.	8-ohdg	27-34	melanocortin 1 receptor	Homo sapiens	104-108
19659742-6	2009	The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.	8-ohdg	27-34	melanocortin 1 receptor	Homo sapiens	171-175
19659742-6	2009	The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.	8-ohdg	27-34	agouti signaling protein	Homo sapiens	232-256
19659742-6	2009	The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.	8-ohdg	27-34	agouti signaling protein	Homo sapiens	258-262
19843683-3	2009	To assess whether supplementation of BRCA1 mutation carriers with selenium have a beneficial effect concerning oxidative stress/DNA damage in the present double-blinded placebo control study, we determined 8-oxodG level in cellular DNA and urinary excretion of 8-oxodG and 8-oxoGua in the mutation carriers.	8-ohdg	206-213	BRCA1 DNA repair associated	Homo sapiens	37-42
19592468-6	2009	However, Nrf2(-/-) mice after TAC developed pathological cardiac hypertrophy, significant myocardial fibrosis and apoptosis, overt heart failure, and increased mortality, which were associated with elevated myocardial levels of 4-hydroxy-2-nonenal and 8-hydroxydeoxyguanosine and a complete blockade of the myocardial expression of several antioxidant genes.	8-ohdg	252-275	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
19843683-3	2009	To assess whether supplementation of BRCA1 mutation carriers with selenium have a beneficial effect concerning oxidative stress/DNA damage in the present double-blinded placebo control study, we determined 8-oxodG level in cellular DNA and urinary excretion of 8-oxodG and 8-oxoGua in the mutation carriers.	8-ohdg	261-268	BRCA1 DNA repair associated	Homo sapiens	37-42
19843683-4	2009	We found that 8-oxodG level in leukocytes DNA is significantly higher in BRCA1 mutation carriers.	8-ohdg	14-21	BRCA1 DNA repair associated	Homo sapiens	73-78
19843683-5	2009	In the distinct subpopulation of BRCA1 mutation carriers without symptoms of cancer who underwent adnexectomy and were supplemented with selenium, the level of 8-oxodG in DNA decreased significantly in comparison with the subgroup without supplementation.	8-ohdg	160-167	BRCA1 DNA repair associated	Homo sapiens	33-38
19843683-9	2009	Altogether, these results suggest that BRCA1 deficiency contributes to 8-oxodG accumulation in cellular DNA, which in turn may be a factor responsible for cancer development in women with mutations, and that the risk to developed breast cancer in BRCA1 mutation carriers may be reduced in selenium-supplemented patients who underwent adnexectomy.	8-ohdg	71-78	BRCA1 DNA repair associated	Homo sapiens	39-44
19631197-0	2009	Butin decreases oxidative stress-induced 8-hydroxy-2"-deoxyguanosine levels via activation of oxoguanine glycosylase 1.	8-ohdg	41-68	8-oxoguanine DNA glycosylase	Homo sapiens	94-118
19623658-0	2009	Elevated level of 8-oxo-7,8-dihydro-2"-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.	8-ohdg	18-53	BRCA1 DNA repair associated	Homo sapiens	71-76
19726680-0	2009	Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2"-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione.	8-ohdg	60-83	aryl hydrocarbon receptor	Homo sapiens	0-25
19726680-12	2009	The decrease in 8-oxo-dGuo levels in AhR-deficient Hepa cells and AhR knockdown H358 cells was validated by immunoaffinity capture stable isotope dilution ([(15)N(5)]8-oxo-dGuo) liquid chromatography-electrospray ionization/multiple reaction monitoring/mass spectrometry.	8-ohdg	16-26	aryl hydrocarbon receptor	Homo sapiens	37-40
19726680-12	2009	The decrease in 8-oxo-dGuo levels in AhR-deficient Hepa cells and AhR knockdown H358 cells was validated by immunoaffinity capture stable isotope dilution ([(15)N(5)]8-oxo-dGuo) liquid chromatography-electrospray ionization/multiple reaction monitoring/mass spectrometry.	8-ohdg	166-176	aryl hydrocarbon receptor	Homo sapiens	37-40
19631197-1	2009	In response to oxidative DNA base damage, oxoguanine glycosylase 1 (OGG1), in a base-excision repair (BER) pathway in mammals, plays a vital role in the repair of 8-hydroxy-2"-deoxyguanosine (8-OHdG), which is a reliable marker of reactive oxygen species (ROS)-induced DNA base modification and contributes to the pathologic process of cancer.	8-ohdg	163-190	8-oxoguanine DNA glycosylase	Homo sapiens	42-66
19631197-1	2009	In response to oxidative DNA base damage, oxoguanine glycosylase 1 (OGG1), in a base-excision repair (BER) pathway in mammals, plays a vital role in the repair of 8-hydroxy-2"-deoxyguanosine (8-OHdG), which is a reliable marker of reactive oxygen species (ROS)-induced DNA base modification and contributes to the pathologic process of cancer.	8-ohdg	163-190	8-oxoguanine DNA glycosylase	Homo sapiens	68-72
19631197-1	2009	In response to oxidative DNA base damage, oxoguanine glycosylase 1 (OGG1), in a base-excision repair (BER) pathway in mammals, plays a vital role in the repair of 8-hydroxy-2"-deoxyguanosine (8-OHdG), which is a reliable marker of reactive oxygen species (ROS)-induced DNA base modification and contributes to the pathologic process of cancer.	8-ohdg	192-198	8-oxoguanine DNA glycosylase	Homo sapiens	42-66
19631197-1	2009	In response to oxidative DNA base damage, oxoguanine glycosylase 1 (OGG1), in a base-excision repair (BER) pathway in mammals, plays a vital role in the repair of 8-hydroxy-2"-deoxyguanosine (8-OHdG), which is a reliable marker of reactive oxygen species (ROS)-induced DNA base modification and contributes to the pathologic process of cancer.	8-ohdg	192-198	8-oxoguanine DNA glycosylase	Homo sapiens	68-72
19631197-5	2009	Suppression of 8-OHdG formation by butin was related to the enhanced mRNA and protein expression of OGG1, which was detected by RT-PCR and Western blot analysis.	8-ohdg	15-21	8-oxoguanine DNA glycosylase	Homo sapiens	100-104
19563869-7	2009	Subjects bearing the hOGG1 Ser/Ser genotype showed lower values of 8-oxodGuo/10(5) dGuo in WBC than those with at least one variant Cys allele (0.34+/-0.16 vs 0.45+/-0.21, p=0.008).	8-ohdg	67-76	8-oxoguanine DNA glycosylase	Homo sapiens	21-26
20049736-5	2009	Methotrexate treatment caused the accumulation of potentially lethal 8-hydroxy-2"-deoxyguanosine (8-OHdG) oxidative DNA lesions in both MSH2 deficient and proficient cells.	8-ohdg	69-96	mutS homolog 2	Homo sapiens	136-140
19542228-0	2009	Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2"-deoxyguanosine adduct.	8-ohdg	130-165	DNA polymerase kappa	Homo sapiens	96-116
19542228-2	2009	Here, we present a detailed analysis of the activity and specificity of hPol kappa bypass opposite the major oxidative adduct 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG).	8-ohdg	126-161	DNA polymerase lambda	Homo sapiens	72-82
19542228-2	2009	Here, we present a detailed analysis of the activity and specificity of hPol kappa bypass opposite the major oxidative adduct 7,8-dihydro-8-oxo-2"-deoxyguanosine (8-oxoG).	8-ohdg	163-169	DNA polymerase lambda	Homo sapiens	72-82
18767135-7	2009	DNA damage measured by DNA migration and the formation of 8-hydroxy-2"-deoxyguanosine (8-OHdG) also increased in cells exposed to BaP, but not in cells exposed to aroclor1254.	8-ohdg	58-85	prohibitin 2	Homo sapiens	130-133
18767135-7	2009	DNA damage measured by DNA migration and the formation of 8-hydroxy-2"-deoxyguanosine (8-OHdG) also increased in cells exposed to BaP, but not in cells exposed to aroclor1254.	8-ohdg	87-93	prohibitin 2	Homo sapiens	130-133
18767135-8	2009	Under the Aroclor 1254 pretreatment condition, BaP-induced EROD activities was enhanced in cells exposed to the medium and high concentrations of aroclor1254 (P &lt; 0.01 for both), whereas in all pretreatment groups aroclor1254 significantly increased BaP-induced DNA migration (P &lt; 0.01 for all) and the 8-OHdG formation (P &lt; 0.05 for all).	8-ohdg	309-315	prohibitin 2	Homo sapiens	47-50
19357934-7	2009	The content of 8-OH-dG in cerebellar DNA isolated by the proteinase K method was measured using an enzyme-linked immunosorbent assay (ELISA); neurotrophin-3 (NT-3) levels in cerebellar homogenates were measured using NT-3 ELISA.	8-ohdg	15-22	neurotrophin 3	Homo sapiens	142-156
20049736-5	2009	Methotrexate treatment caused the accumulation of potentially lethal 8-hydroxy-2"-deoxyguanosine (8-OHdG) oxidative DNA lesions in both MSH2 deficient and proficient cells.	8-ohdg	98-104	mutS homolog 2	Homo sapiens	136-140
20049736-6	2009	In MSH2 proficient cells, these lesions were rapidly cleared, while in MSH2 deficient cells 8-OHdG lesions persisted, potentially explaining the selectivity of methotrexate.	8-ohdg	92-98	mutS homolog 2	Homo sapiens	71-75
20049736-7	2009	Short interfering (si)RNA mediated silencing of the target of methotrexate, dihydrofolate reductase (DHFR), was also selective for MSH2 deficiency and also caused an accumulation of 8-OHdG.	8-ohdg	182-188	dihydrofolate reductase	Homo sapiens	76-99
20049736-7	2009	Short interfering (si)RNA mediated silencing of the target of methotrexate, dihydrofolate reductase (DHFR), was also selective for MSH2 deficiency and also caused an accumulation of 8-OHdG.	8-ohdg	182-188	dihydrofolate reductase	Homo sapiens	101-105