PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
14830-11	1977	The carbodiimide-reactive groups were not identical with the two carboxylate groups recently found to react with conduritol-B-epoxide, an active-site-directed inhibitor of sucrase-isomaltase (Quaroni, A. and Semenza, G., 1976, J. Biol.	conduritol epoxide	113-133	sucrase-isomaltase, intestinal	Oryctolagus cuniculus	172-190
33720-2	1979	Injection of a single dose of conduritol B epoxide into mice produced almost complete destruction of glucocerebrosidase (D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45) in liver, spleen, brain, and kidney within 5 h. Restoration of activity became noticeable within 1 day (2 days in the case of brain) and was about 80% of normal within 16 days.	conduritol epoxide	30-50	glucosidase, beta, acid	Mus musculus	101-119
560212-0	1977	Stereospecific ring opening of conduritol-B-epoxide by an active site asparatate residue of sucrase-isomaltase.	conduritol epoxide	31-51	sucrase-isomaltase	Homo sapiens	92-110
560212-1	1977	Conduritol-B-epoxide inactivates sucrase-isomaltase (sucrose alpha-glucohydrolase, EC 3.2.1.48-dextrin 6-alpha-glucohydrolase, EC 3.2.1.10) irreversibly with incorporation of 1 mol inhibitor/mol subunit, the affinity label being bound in both subunits to a beta-carboxyl group of an aspartic acid (Quaroni, A. and Semnza; G. (1976) J. Biol.	conduritol epoxide	0-20	sucrase-isomaltase	Homo sapiens	33-51
27655403-4	2016	A nGD cell model (CBE-N2a) was created by inhibiting acid beta-glucosidase (GCase) in N2a cells with conduritol B epoxide (CBE).	conduritol epoxide	101-121	glucosidase, beta, acid	Mus musculus	76-81
32743826-4	2021	We now induce nGD in mice by injection with conduritol B-epoxide (CBE), an irreversible inhibitor of acid beta-glucosidase (GCase), the enzyme defective in nGD, with or without co-injection with Genz-667161, a prototype for SRT which crosses the BBB.	conduritol epoxide	44-64	glucosidase, beta, acid	Mus musculus	124-129
32743826-4	2021	We now induce nGD in mice by injection with conduritol B-epoxide (CBE), an irreversible inhibitor of acid beta-glucosidase (GCase), the enzyme defective in nGD, with or without co-injection with Genz-667161, a prototype for SRT which crosses the BBB.	conduritol epoxide	66-69	glucosidase, beta, acid	Mus musculus	124-129
28166796-5	2017	Chemically-induced Gaucher macrophages were developed by differentiateing THP-1 monocytes to macrophages by treatment with phorbol 12-myristate 13-acetate (PMA) and then inhibiting intracellular GCase with conduritol B-epoxide (CBE), a specific irreversible inhibitor of GCase activity, and supplementing the medium with exogenous GlcCer.	conduritol epoxide	206-226	glucosylceramidase beta	Homo sapiens	195-200
28242245-4	2017	Using SH-SY5Y cells, complex I deficiency was modelled by using rotenone whilst GBA1 deficiency was modelled by the use of conduritol B epoxide (CBE).	conduritol epoxide	123-143	glucosylceramidase beta	Homo sapiens	80-84
27234572-3	2016	Chemical induction of GD by inhibition of acid beta-glucosidase (GCase) using the irreversible inhibitor conduritol B-epoxide (CBE) is particularly attractive, although few systematic studies examining the effect of CBE on the development of symptoms associated with neurological forms of GD have been performed.	conduritol epoxide	105-125	glucosidase, beta, acid	Mus musculus	47-63
27234572-3	2016	Chemical induction of GD by inhibition of acid beta-glucosidase (GCase) using the irreversible inhibitor conduritol B-epoxide (CBE) is particularly attractive, although few systematic studies examining the effect of CBE on the development of symptoms associated with neurological forms of GD have been performed.	conduritol epoxide	105-125	glucosidase, beta, acid	Mus musculus	65-70
27126635-5	2016	Partial inhibition of glucocerebrosidase activity in PrP-A53T-SNCA mice using the covalent inhibitor conduritol-B-epoxide induced a profound increase in soluble alpha-synuclein in the CNS and exacerbated cognitive and motor deficits.	conduritol epoxide	101-121	glucosidase, beta, acid	Mus musculus	22-40
27126635-5	2016	Partial inhibition of glucocerebrosidase activity in PrP-A53T-SNCA mice using the covalent inhibitor conduritol-B-epoxide induced a profound increase in soluble alpha-synuclein in the CNS and exacerbated cognitive and motor deficits.	conduritol epoxide	101-121	prion protein	Mus musculus	53-56
27126635-5	2016	Partial inhibition of glucocerebrosidase activity in PrP-A53T-SNCA mice using the covalent inhibitor conduritol-B-epoxide induced a profound increase in soluble alpha-synuclein in the CNS and exacerbated cognitive and motor deficits.	conduritol epoxide	101-121	synuclein, alpha	Mus musculus	62-66
27126635-5	2016	Partial inhibition of glucocerebrosidase activity in PrP-A53T-SNCA mice using the covalent inhibitor conduritol-B-epoxide induced a profound increase in soluble alpha-synuclein in the CNS and exacerbated cognitive and motor deficits.	conduritol epoxide	101-121	synuclein, alpha	Mus musculus	161-176
26909767-6	2016	We established that zebrafish has endogenous beta-glucosidase activity toward lipid- and water-soluble GBA2 substrates, which can be inhibited by miglustat, N-butyldeoxygalactonojirimycin, and conduritol B epoxide.	conduritol epoxide	193-213	glucosidase, beta (bile acid) 2	Danio rerio	103-107
26995090-4	2016	Additionally, three dimensional cultured skin was incubated with SM-L and the beta-GCase inhibitor conduritol B epoxide (CBE) and the ceramide content determined by high performance thin layer chromatography.	conduritol epoxide	99-119	glucosylceramidase beta	Homo sapiens	78-88
26104567-5	2015	Conversely, we could show that inhibition of GCase activity with conduritol-B-epoxide (CBE) enhances both alpha-Syn and MPP(+) induced toxicity in vitro.	conduritol epoxide	65-85	glucosidase, beta, acid	Mus musculus	45-50
26104567-5	2015	Conversely, we could show that inhibition of GCase activity with conduritol-B-epoxide (CBE) enhances both alpha-Syn and MPP(+) induced toxicity in vitro.	conduritol epoxide	65-85	synuclein, alpha	Mus musculus	106-115
26104567-5	2015	Conversely, we could show that inhibition of GCase activity with conduritol-B-epoxide (CBE) enhances both alpha-Syn and MPP(+) induced toxicity in vitro.	conduritol epoxide	87-90	glucosidase, beta, acid	Mus musculus	45-50
26104567-5	2015	Conversely, we could show that inhibition of GCase activity with conduritol-B-epoxide (CBE) enhances both alpha-Syn and MPP(+) induced toxicity in vitro.	conduritol epoxide	87-90	synuclein, alpha	Mus musculus	106-115
24599400-9	2014	In cultured wild-type brain cortical neural cells, the GCase-irreversible inhibitor, conduritol B epoxide (CBE), reproduced the APP/alpha-synuclein aggregation and the accumulation of GC/GS.	conduritol epoxide	85-105	synuclein, alpha	Mus musculus	132-147
23880767-4	2013	We have addressed the ambiguity surrounding one of the defining characteristics of GBA2, which is its sensitivity to inhibition by conduritol B epoxide (CBE).	conduritol epoxide	131-151	glucosidase beta 2	Mus musculus	83-87
24211208-8	2013	In addition, purified recombinant GBA1 exhibits conduritol B-epoxide-sensitive cholesterol glucosylation activity.	conduritol epoxide	48-68	glucosylceramidase beta	Homo sapiens	34-38
23880767-4	2013	We have addressed the ambiguity surrounding one of the defining characteristics of GBA2, which is its sensitivity to inhibition by conduritol B epoxide (CBE).	conduritol epoxide	153-156	glucosidase beta 2	Mus musculus	83-87
22451348-4	2012	Similarly, conduritol B epoxide, an inhibitor of beta-glucocerebrosidase, significantly down-regulated SC ceramide levels and significantly increased glucosylceramide levels.	conduritol epoxide	11-31	glucosylceramidase beta	Homo sapiens	49-72
19587377-5	2009	Transcriptome analysis on normal MSCs treated with the glucocerebrosidase inhibitor conduritol B epoxide showed an up-regulation of an array of inflammatory mediators, including CCL2, and other differentially regulated pathways.	conduritol epoxide	84-104	C-C motif chemokine ligand 2	Homo sapiens	178-182
19651460-0	2010	Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness.	conduritol epoxide	66-86	CD1d molecule	Homo sapiens	19-23
19651460-4	2010	We also show that retinoic acid (RA) and the beta-glucocerebrosidase inhibitor conduritol-B-epoxide (CBE) lead to upregulation of CD1d expression by THP-1 cells, which correlated with an increase in mRNA expression.	conduritol epoxide	79-99	glucosylceramidase beta	Homo sapiens	45-68
19651460-4	2010	We also show that retinoic acid (RA) and the beta-glucocerebrosidase inhibitor conduritol-B-epoxide (CBE) lead to upregulation of CD1d expression by THP-1 cells, which correlated with an increase in mRNA expression.	conduritol epoxide	79-99	CD1d molecule	Homo sapiens	130-134
19576930-3	2009	We inhibited glucocerebrosidase (GCase) with conduritol B epoxide (CBE) in neuroblastoma cells and mice to test whether a biological link exists between GCase activity and alpha-syn.	conduritol epoxide	45-65	glucosidase, beta, acid	Mus musculus	13-31
19576930-3	2009	We inhibited glucocerebrosidase (GCase) with conduritol B epoxide (CBE) in neuroblastoma cells and mice to test whether a biological link exists between GCase activity and alpha-syn.	conduritol epoxide	45-65	glucosidase, beta, acid	Mus musculus	33-38
15890646-4	2005	Here, we show that apoA-I-mediated cholesterol efflux was inhibited (by up to 53% over 8 h) when fibroblasts were treated with lactosylceramide or the glucocerebrosidase inhibitor conduritol B epoxide.	conduritol epoxide	180-200	apolipoprotein A1	Homo sapiens	19-25
18346921-4	2008	Conduritol B epoxide (CBE, a covalent inhibitor of GCase) treatment (for 8-12 days) of wild type, D409H, D409V or V394L homozygotes recapitulated the CNS phenotype of the kn-9H mice with seizures, tail arching, shaking, tremor, quadriparesis, extensive neuronal degeneration loss and apoptosis, and death by the age of 14 days.	conduritol epoxide	0-20	glucosidase, beta, acid	Mus musculus	51-56
17482853-2	2007	We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis.	conduritol epoxide	54-74	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	146-185
17482853-2	2007	We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis.	conduritol epoxide	54-74	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	187-190
15817452-0	2005	X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide.	conduritol epoxide	67-87	glucosylceramidase beta	Homo sapiens	25-46
15916690-3	2005	We now show that GluCerase-deficient monocytes from GD patients or monocytes from healthy subjects treated with conduritol-B-epoxide (CBE), an irreversible inhibitor of GluCerase activity, display high levels of surface expression of the lipid-binding molecule CD1d.	conduritol epoxide	112-132	CD1d molecule	Homo sapiens	261-265
10037475-2	1999	Incubation of NG108-15 cells with conduritol-B-epoxide, a covalent inhibitor of glucosylceramidase, raised the intracellular concentration of glucosylceramide (GC) by more than fourfold, indicating a glycolipid composition equivalent to that of Gaucher"s cells.	conduritol epoxide	34-54	glucosidase, beta, acid	Mus musculus	80-98
12401882-5	2002	Treatment of fibroblasts or RAW macrophages with conduritol B epoxide, an inhibitor of lysosomal glucocerebrosidase, resulted in a change in the endocytic targeting of lactosylceramide from the Golgi to the lysosomes.	conduritol epoxide	49-69	glucosylceramidase beta	Homo sapiens	87-115
1386724-8	1992	Conduritol B epoxide is also known to inhibit glucocerebrosidase and induce Gaucher"s like-disease in mice by repetitive injection.	conduritol epoxide	0-20	glucosidase, beta, acid	Mus musculus	46-64
7769132-5	1995	Topical applications of conduritol B epoxide, a specific irreversible inhibitor of beta-glucocerebrosidase, increased epidermal GlcCer levels twofold, an alteration localized largely to the basal, proliferative cell layer (fourfold increase); and stimulated epidermal proliferation (2.3-fold elevation in [3H]thymidine incorporation; P < or = 0.001), localized autoradiographically again to the basal layer, and resulting in epidermal hyperplasia.	conduritol epoxide	24-44	glucosidase, beta, acid	Mus musculus	83-106
7766184-1	1995	The modification of amino acid residues in sugar beet alpha-glucosidase with conduritol B epoxide (CBE), an affinity labeling reagent, inactivated the enzyme.	conduritol epoxide	77-97	alpha-glucosidase	Beta vulgaris subsp. vulgaris	54-71
1386724-9	1992	Cyclophellitol was shown to be more potent than conduritol B epoxide in inhibition of glucocerebrosidase and in induction of the neural abnormality.	conduritol epoxide	48-68	glucosidase, beta, acid	Mus musculus	86-104
3087971-3	1986	Conduritol B epoxide (CBE) and its brominated derivative are mechanism-based inhibitors which bind covalently to the catalytic site of acid beta-glucosidase.	conduritol epoxide	0-20	glucosylceramidase beta	Homo sapiens	135-156
1731615-2	1992	The role of glucosylceramide metabolism was explored further by exposing Madin-Darby canine kidney (MDCK) cells to the beta-glucosidase inhibitor conduritol B epoxide, which produced time-dependent and concentration-dependent increases in glucosylceramide levels and decreased bradykinin-stimulated inositol trisphosphate formation from isolated MDCK cell membranes.	conduritol epoxide	146-166	kininogen 1	Canis lupus familiaris	277-287
34459538-5	2021	Here we show that the xylopyranose preference also holds up for covalent inhibitors: xylose-configured cyclophellitol and cyclophellitol aziridines selectively react with GBA over GBA2 and GBA3 in vitro and in vivo , and that the xylose-configured cyclophellitol is more potent and more selective for GBA than the classical GBA inhibitor, conduritol B-epoxide (CBE).	conduritol epoxide	339-359	glucosylceramidase beta	Homo sapiens	171-174
34459538-5	2021	Here we show that the xylopyranose preference also holds up for covalent inhibitors: xylose-configured cyclophellitol and cyclophellitol aziridines selectively react with GBA over GBA2 and GBA3 in vitro and in vivo , and that the xylose-configured cyclophellitol is more potent and more selective for GBA than the classical GBA inhibitor, conduritol B-epoxide (CBE).	conduritol epoxide	339-359	glucosylceramidase beta	Homo sapiens	324-327
34459538-5	2021	Here we show that the xylopyranose preference also holds up for covalent inhibitors: xylose-configured cyclophellitol and cyclophellitol aziridines selectively react with GBA over GBA2 and GBA3 in vitro and in vivo , and that the xylose-configured cyclophellitol is more potent and more selective for GBA than the classical GBA inhibitor, conduritol B-epoxide (CBE).	conduritol epoxide	361-364	glucosylceramidase beta	Homo sapiens	171-174
34459538-5	2021	Here we show that the xylopyranose preference also holds up for covalent inhibitors: xylose-configured cyclophellitol and cyclophellitol aziridines selectively react with GBA over GBA2 and GBA3 in vitro and in vivo , and that the xylose-configured cyclophellitol is more potent and more selective for GBA than the classical GBA inhibitor, conduritol B-epoxide (CBE).	conduritol epoxide	361-364	glucosylceramidase beta	Homo sapiens	324-327
1856189-2	1991	The substrate analogue conduritol B epoxide (CBE) is demonstrated to be an active site-directed inhibitor of human lysosomal alpha-glucosidase.	conduritol epoxide	23-43	alpha glucosidase	Homo sapiens	115-142
3943537-1	1986	The kinetics of glucocerebrosidase synthesis and degradation in rat peritoneal macrophages and in human fibroblasts have been studied using conduritol B epoxide (CBE), an irreversible and specific inhibitor of mammalian glucocerebrosidase.	conduritol epoxide	140-160	glucosylceramidase beta	Rattus norvegicus	220-238
6693432-5	1984	These effectors also increased the reactivity of glucocerebrosidase to the inhibitor conduritol B epoxide; HSF alone had no effect (t1/2 = 19 +/- 0.5 min) whereas the maximum rate of inactivation (t1/2 = 4.0 min) by conduritol B epoxide was achieved in the presence of a mixture of PS (1 microgram) and HSF (3 micrograms).	conduritol epoxide	85-105	interleukin 6	Homo sapiens	107-110