PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8831778-5	1996	Receptor binding results suggest that the preferred topography of the Trp30 residue for CCK-B receptor binding may be the 2S,3S (erythro-L) configuration whereas for the delta-opioid receptor it may be the 2S,3R (threo-L) configuration.	3s	125-127	cholecystokinin B receptor	Homo sapiens	88-102
10086984-1	1999	The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome preparations.	3s	43-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	114-139
1448494-1	1992	3S(-)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-yl) -1H-indole-2-carboxamide (devazepide), a potent and selective cholecystokininA (CCKA) antagonist, has been shown to reverse the inhibitory effect of exogenously administered CCK-8 on food intake.	3s	0-2	cholecystokinin	Rattus norvegicus	153-156
1648137-5	1991	For example, [(2S,3S)-beta-MePhe4]DPDPE (2) is 1800-fold selective in binding to the delta vs mu receptor, making it one of the most selective delta opioid receptor ligands in the enkephalin series as assessed by the rat brain binding assay, whereas the corresponding (2R,3R)-beta-Me-p-NO2Phe-containing analogue 9 is only 4.5-fold selective (nonselective) in this same assay.	3s	18-20	proenkephalin	Rattus norvegicus	180-190
29653168-6	2018	The activities of caspase-3 and caspase-9 were also increased in GAP-3S-treated MCF-7 cells compared to untreated cells.	3s	69-71	caspase 3	Homo sapiens	18-27
3014520-1	1986	3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepine-3-yl)-1H-indole-2-carboxamide (L-364,718) interacted in a competitive manner with rat pancreatic cholecystokinin (CCK) receptors as determined by Scatchard analysis of the specific binding of 125I-labeled CCK.	3s	0-2	cholecystokinin	Rattus norvegicus	182-185
3014520-1	1986	3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepine-3-yl)-1H-indole-2-carboxamide (L-364,718) interacted in a competitive manner with rat pancreatic cholecystokinin (CCK) receptors as determined by Scatchard analysis of the specific binding of 125I-labeled CCK.	3s	0-2	cholecystokinin	Rattus norvegicus	273-276
238846-16	1975	The malate formed from 3S-3-hydroxy[2-3H2]butyryl-CoA on incubation with fumarase lost nearly 50%, that derived from 2R,3S-3-hydroxy[2-2H1,3H1]butyryl-CoA (plus 3R-diastereomer) retained about 26% and that derived from 2S,3S-3-hydroxy[2-1H1,3H1]butyryl-CoA retained about 78% of its total tritium content.	3s	23-25	fumarate hydratase	Homo sapiens	73-81
29653168-6	2018	The activities of caspase-3 and caspase-9 were also increased in GAP-3S-treated MCF-7 cells compared to untreated cells.	3s	69-71	caspase 9	Homo sapiens	32-41
27151651-6	2016	In the present study, we show that deletion of a triple serine (3S) motif (Ser-359 to Ser-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17, but not ADAM10.	3s	64-66	interleukin 6 receptor	Homo sapiens	150-155
28716707-7	2017	3S is more effective than fr-HMGB1 in stimulating hcFbs migration and Src phosphorylation being active at lower concentrations and in oxidizing conditions.	3s	0-2	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
28716707-9	2017	Interestingly, 3S interacts with CXCR4 and induces a different receptor conformation than CXCL12.	3s	15-17	C-X-C motif chemokine receptor 4	Homo sapiens	33-38
27151651-6	2016	In the present study, we show that deletion of a triple serine (3S) motif (Ser-359 to Ser-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17, but not ADAM10.	3s	64-66	ADAM metallopeptidase domain 17	Homo sapiens	168-174
27151651-6	2016	In the present study, we show that deletion of a triple serine (3S) motif (Ser-359 to Ser-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17, but not ADAM10.	3s	64-66	ADAM metallopeptidase domain 10	Homo sapiens	184-190
24152899-8	2013	Among the compounds tested, 2-phenyl-3-(5-styryl- -1,3,4-thiadiazol-2-yl)-thiazolidin-4-one (3s) elicited superior antioxidant activity with IC50 of 161.93 mumol L-1.	3s	93-95	immunoglobulin kappa variable 1-16	Homo sapiens	162-165
27031925-1	2016	A series of 12 analogues of the Cer transfer protein (CERT) antagonist HPA-12 with long aliphatic chains were prepared as their (1R,3S)-syn and (1R,3R)-anti stereoisomers from pivotal chiral oxoamino acids.	3s	132-134	ceramide transporter 1	Homo sapiens	32-52
27031925-1	2016	A series of 12 analogues of the Cer transfer protein (CERT) antagonist HPA-12 with long aliphatic chains were prepared as their (1R,3S)-syn and (1R,3R)-anti stereoisomers from pivotal chiral oxoamino acids.	3s	132-134	ceramide transporter 1	Homo sapiens	54-58
24094148-4	2014	RESULTS: Nonoxidizable HMGB1 with a triple cysteine-to-serine replacement (3S-HMGB1) was ineffective on NMDA response.	3s	75-77	high mobility group box 1	Mus musculus	78-83
23696512-2	2013	We previously identified 3S, a critical conserved motif of gp41 that induces the NKp44L ligand of an activating NK receptor.	3s	25-27	lysine methyltransferase 2E (inactive)	Homo sapiens	81-87
21862335-5	2011	The basis of significant inhibition of xanthine oxidase by 3s was rationalized by its molecular docking into catalytic site of xanthine oxidase.	3s	59-61	xanthine dehydrogenase	Mus musculus	127-143
22989687-3	2012	We have shown that 3S, a unique motif of gp41, is highly conserved in HIV-1 strains and specifically induces NKp44L, a ligand of the natural cytotoxicity receptor NKp44, on CD4(+) T cells, rendering them sensitive to NK lysis.	3s	19-21	lysine methyltransferase 2E (inactive)	Homo sapiens	109-115
22989687-3	2012	We have shown that 3S, a unique motif of gp41, is highly conserved in HIV-1 strains and specifically induces NKp44L, a ligand of the natural cytotoxicity receptor NKp44, on CD4(+) T cells, rendering them sensitive to NK lysis.	3s	19-21	CD4 molecule	Homo sapiens	173-176
21862335-5	2011	The basis of significant inhibition of xanthine oxidase by 3s was rationalized by its molecular docking into catalytic site of xanthine oxidase.	3s	59-61	xanthine dehydrogenase	Mus musculus	39-55
22732471-2	2012	We previously showed that 3S, a unique motif of the HIV-1 gp41 envelop protein, is highly conserved in HIV-1 strains and induces expression of NKp44L, rendering CD4 cells sensitive to NK killing.	3s	26-28	CD4 molecule	Homo sapiens	161-164
22869893-5	2012	A nonoxidizable HMGB1 mutant in which serines replace all cysteines (3S-HMGB1) does not promote cytokine production, but is more effective than wild-type HMGB1 in recruiting leukocytes in vivo.	3s	69-71	high mobility group box 1	Homo sapiens	16-21
22869893-5	2012	A nonoxidizable HMGB1 mutant in which serines replace all cysteines (3S-HMGB1) does not promote cytokine production, but is more effective than wild-type HMGB1 in recruiting leukocytes in vivo.	3s	69-71	high mobility group box 1	Homo sapiens	72-77
22869893-5	2012	A nonoxidizable HMGB1 mutant in which serines replace all cysteines (3S-HMGB1) does not promote cytokine production, but is more effective than wild-type HMGB1 in recruiting leukocytes in vivo.	3s	69-71	high mobility group box 1	Homo sapiens	72-77
19718985-7	2009	NKp44L ligand expression is strongly induced by the highly conserved 3S motif of the HIV-1 envelope protein gp41.	3s	69-71	lysine methyltransferase 2E (inactive)	Homo sapiens	0-6
20617170-3	2010	We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD4(+) T cells, rendering them susceptible to autologous NK killing.	3s	30-32	lysine methyltransferase 2E (inactive)	Homo sapiens	83-89
20617170-3	2010	We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD4(+) T cells, rendering them susceptible to autologous NK killing.	3s	30-32	CD4 molecule	Homo sapiens	164-167
20617170-4	2010	However, the mechanism of the 3S mediated NKp44L surface expression on CD4(+) T cells remains unknown.	3s	30-32	lysine methyltransferase 2E (inactive)	Homo sapiens	42-48
20617170-4	2010	However, the mechanism of the 3S mediated NKp44L surface expression on CD4(+) T cells remains unknown.	3s	30-32	CD4 molecule	Homo sapiens	71-74
20617170-5	2010	Here, using immunoprecipitation, ELISA and blocking antibodies, we demonstrate that the 3S motif of HIV-1 gp41 binds to gC1qR on CD4(+) T cells.	3s	88-90	complement C1q binding protein	Homo sapiens	120-125
20617170-5	2010	Here, using immunoprecipitation, ELISA and blocking antibodies, we demonstrate that the 3S motif of HIV-1 gp41 binds to gC1qR on CD4(+) T cells.	3s	88-90	CD4 molecule	Homo sapiens	129-132
20617170-8	2010	Using plasmid encoding wild type or mutated form of p190 RhoGAP, we show that 3S mediated NKp44L surface expression on CD4(+) T cells is dependent on p190 RhoGAP.	3s	78-80	Rho GTPase activating protein 35	Homo sapiens	52-63
20617170-8	2010	Using plasmid encoding wild type or mutated form of p190 RhoGAP, we show that 3S mediated NKp44L surface expression on CD4(+) T cells is dependent on p190 RhoGAP.	3s	78-80	lysine methyltransferase 2E (inactive)	Homo sapiens	90-96
20617170-8	2010	Using plasmid encoding wild type or mutated form of p190 RhoGAP, we show that 3S mediated NKp44L surface expression on CD4(+) T cells is dependent on p190 RhoGAP.	3s	78-80	CD4 molecule	Homo sapiens	119-122
20617170-8	2010	Using plasmid encoding wild type or mutated form of p190 RhoGAP, we show that 3S mediated NKp44L surface expression on CD4(+) T cells is dependent on p190 RhoGAP.	3s	78-80	Rho GTPase activating protein 35	Homo sapiens	150-161
18078582-5	2007	In an earlier communication, we have shown that both human serum transferrin and lactoferrin bind to 3S-gel.	3s	101-103	transferrin	Homo sapiens	65-76
16621578-4	2006	Among the compounds tested, N-[4-(benzofuran-2-yl)benzoyl] 4-amino-4S-hydroxymethylbutyric acid hydroxamates derived from L-glutamic acid demonstrated more potent inhibitory activity against MMP-2 and MMP-9 compared with the corresponding 2S-hydroxy analogs or 3S-hydroxy analogs, respectively, which were derived from (-)-malic acid.	3s	261-263	matrix metallopeptidase 2	Homo sapiens	191-196
16954720-3	2006	The objectives were to determine whether anti-3S antibodies were produced, could counteract 3S-CD4 interactions and were correlated to CD4 cell count and NKp44L expression in HIV-infected patients.	3s	46-48	CD4 molecule	Homo sapiens	95-98
16954720-3	2006	The objectives were to determine whether anti-3S antibodies were produced, could counteract 3S-CD4 interactions and were correlated to CD4 cell count and NKp44L expression in HIV-infected patients.	3s	46-48	CD4 molecule	Homo sapiens	135-138
16954720-3	2006	The objectives were to determine whether anti-3S antibodies were produced, could counteract 3S-CD4 interactions and were correlated to CD4 cell count and NKp44L expression in HIV-infected patients.	3s	46-48	lysine methyltransferase 2E (inactive)	Homo sapiens	154-160
17178770-5	2007	The results of kinetic analysis of DHEA and DHEA-3S 16alpha-hydroxylations by CYP3A7, CYP3A4, and CYP3A chimeras suggested that the amino acid residues from Leu(210) to Glu(279) were important to express the specificity for substrates as CYP3A7.	3s	49-51	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	78-84
17178770-5	2007	The results of kinetic analysis of DHEA and DHEA-3S 16alpha-hydroxylations by CYP3A7, CYP3A4, and CYP3A chimeras suggested that the amino acid residues from Leu(210) to Glu(279) were important to express the specificity for substrates as CYP3A7.	3s	49-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
17178770-5	2007	The results of kinetic analysis of DHEA and DHEA-3S 16alpha-hydroxylations by CYP3A7, CYP3A4, and CYP3A chimeras suggested that the amino acid residues from Leu(210) to Glu(279) were important to express the specificity for substrates as CYP3A7.	3s	49-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-83
16464863-11	2006	These data are used to review chromophore biosynthesis and propose that NinaG acts in the conversion of (3R)-3-hydroxyretinol to the 3S enantiomer.	3s	133-135	ninaG	Drosophila melanogaster	72-77
12966080-2	2003	The flavoenzyme medium-chain acyl-CoA dehydrogenase (MCAD) eliminates the alpha-proton of the substrate analog, 3-thiaoctanoyl-CoA (3S-C8-CoA), to form a charge-transfer complex with deprotonated 3S-C8-CoA.	3s	132-134	acyl-CoA dehydrogenase medium chain	Homo sapiens	16-51
12966080-2	2003	The flavoenzyme medium-chain acyl-CoA dehydrogenase (MCAD) eliminates the alpha-proton of the substrate analog, 3-thiaoctanoyl-CoA (3S-C8-CoA), to form a charge-transfer complex with deprotonated 3S-C8-CoA.	3s	132-134	acyl-CoA dehydrogenase medium chain	Homo sapiens	53-57
12966080-2	2003	The flavoenzyme medium-chain acyl-CoA dehydrogenase (MCAD) eliminates the alpha-proton of the substrate analog, 3-thiaoctanoyl-CoA (3S-C8-CoA), to form a charge-transfer complex with deprotonated 3S-C8-CoA.	3s	196-198	acyl-CoA dehydrogenase medium chain	Homo sapiens	16-51
12966080-2	2003	The flavoenzyme medium-chain acyl-CoA dehydrogenase (MCAD) eliminates the alpha-proton of the substrate analog, 3-thiaoctanoyl-CoA (3S-C8-CoA), to form a charge-transfer complex with deprotonated 3S-C8-CoA.	3s	196-198	acyl-CoA dehydrogenase medium chain	Homo sapiens	53-57
15369342-3	2003	Chiral HPLC comparisons of racemic 1 (from biomimetic cyclization of N-pivaloyl-4) with the LUP1 product and authentic 1 established the absolute stereochemistry of petromindole (3S) as that of cyclic triterpenes.	3s	179-181	lupeol synthase 1	Arabidopsis thaliana	92-96