PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21164388-8 2011 A significant (P<0.05) decrease (approximately 25%) in glucuronidation activity (Vmax/KM) was observed against all polycyclic aromatic hydrocarbons substrates for the UGT2A1(75Lys308Gly) variant compared with homogenates from wildtype UGT2A1(75Lys308Gly); no activity was observed for cell homogenates overexpressing the UGT2A1 variant for all substrates tested. 75lys308gly 177-188 UDP glucuronosyltransferase 2 family, polypeptide A1 Mus musculus 170-176 21164388-8 2011 A significant (P<0.05) decrease (approximately 25%) in glucuronidation activity (Vmax/KM) was observed against all polycyclic aromatic hydrocarbons substrates for the UGT2A1(75Lys308Gly) variant compared with homogenates from wildtype UGT2A1(75Lys308Gly); no activity was observed for cell homogenates overexpressing the UGT2A1 variant for all substrates tested. 75lys308gly 177-188 UDP glucuronosyltransferase 2 family, polypeptide A1 Mus musculus 238-244 21164388-8 2011 A significant (P<0.05) decrease (approximately 25%) in glucuronidation activity (Vmax/KM) was observed against all polycyclic aromatic hydrocarbons substrates for the UGT2A1(75Lys308Gly) variant compared with homogenates from wildtype UGT2A1(75Lys308Gly); no activity was observed for cell homogenates overexpressing the UGT2A1 variant for all substrates tested. 75lys308gly 177-188 UDP glucuronosyltransferase 2 family, polypeptide A1 Mus musculus 238-244 21164388-8 2011 A significant (P<0.05) decrease (approximately 25%) in glucuronidation activity (Vmax/KM) was observed against all polycyclic aromatic hydrocarbons substrates for the UGT2A1(75Lys308Gly) variant compared with homogenates from wildtype UGT2A1(75Lys308Gly); no activity was observed for cell homogenates overexpressing the UGT2A1 variant for all substrates tested. 75lys308gly 245-256 UDP glucuronosyltransferase 2 family, polypeptide A1 Mus musculus 170-176 21164388-6 2011 Cell homogenates prepared from wildtype UGT2A1(75Lys308Gly) overexpressing HEK293 cells showed significant glucuronidation activity against a variety of polycyclic aromatic hydrocarbons including, 1-hydroxy-benzo(a)pyrene, benzo(a)pyrene-7,8-diol, and 5-methylchrysene-1,2-diol. 75lys308gly 47-58 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 40-46