PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33512718-7	2021	In addition, we have observed that more serum pro-inflammatory cytokines TNF-alpha and IL-6 in the lincRNA-EPS-/- NaTc-SAP mice and more extracellular HMGB1 around injured acinar cells in the pancreas from lincRNA-EPS-/- NaTc-SAP mice, compared to their respective controls.	natc	114-118	SH2 domain containing 1A	Mus musculus	119-122
19202195-4	2009	In contrast, ABCB4 mediates the secretion of phospholipids and cholesterol in the presence of sodium taurocholate (NaTC) but not in the presence of apoA-I.	natc	115-119	ATP binding cassette subfamily B member 4	Homo sapiens	13-18
29626482-4	2018	Molecular dynamic simulations of lipase-colipase complex, lipase and colipase were performed in the presence of a model bile salt, sodium taurocholate (NaTC), at its near-CMC and supra-micellar concentrations.	natc	152-156	colipase	Homo sapiens	40-48
28291657-11	2017	Mediated by PPARgamma, oxPOPC (50 muM) inhibited the CCL2 overexpression found in NaTc-treated acini.	natc	82-86	peroxisome proliferator activated receptor gamma	Homo sapiens	12-21
28291657-11	2017	Mediated by PPARgamma, oxPOPC (50 muM) inhibited the CCL2 overexpression found in NaTc-treated acini.	natc	82-86	latexin	Homo sapiens	34-37
28291657-11	2017	Mediated by PPARgamma, oxPOPC (50 muM) inhibited the CCL2 overexpression found in NaTc-treated acini.	natc	82-86	C-C motif chemokine ligand 2	Homo sapiens	53-57
26964921-10	2016	The values of binding constant for sodium cholate (NaC) and sodium taurocholate (NaTC) are 2.66 x 10(5) and 2.72 x 10(4) M(-1) respectively.	natc	81-85	synuclein alpha	Homo sapiens	51-54
25549008-1	2015	The present study demonstrates a detailed characterization of the interaction of a series of bile salts, sodium deoxycholate (NaDC), sodium cholate (NaC), and sodium taurocholate (NaTC), with a model transport protein, human serum albumin (HSA).	natc	180-184	albumin	Homo sapiens	225-238
32187959-11	2020	RESULTS: Ductal perfusion of NaTC caused significant increases in serum lipase, amylase and pancreatic histopathology (inflammatory cell infiltration, interstitial edema, and acinar cell necrosis).	natc	29-33	lipase G, endothelial type	Rattus norvegicus	72-78
32187959-13	2020	Moreover, apoptotic cell death markers (caspase-9, cleaved-caspase-3, and TUNEL) and kidney ER stress proteins (BIP, IRE1-alpha, XBP1s, and CHOP) were elevated after NaTC administration.	natc	166-170	caspase 9	Homo sapiens	40-49
32187959-13	2020	Moreover, apoptotic cell death markers (caspase-9, cleaved-caspase-3, and TUNEL) and kidney ER stress proteins (BIP, IRE1-alpha, XBP1s, and CHOP) were elevated after NaTC administration.	natc	166-170	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	117-127
27555049-2	2016	The Saccharomyces cerevisiae protein Arl3 depends on interaction with Sys1 for its localization to the Golgi and this targeting strictly requires NatC-mediated N-terminal acetylation of Arl3.	natc	146-150	Arf family GTPase ARL3	Saccharomyces cerevisiae S288C	37-41
27555049-2	2016	The Saccharomyces cerevisiae protein Arl3 depends on interaction with Sys1 for its localization to the Golgi and this targeting strictly requires NatC-mediated N-terminal acetylation of Arl3.	natc	146-150	Sys1p	Saccharomyces cerevisiae S288C	70-74
27555049-2	2016	The Saccharomyces cerevisiae protein Arl3 depends on interaction with Sys1 for its localization to the Golgi and this targeting strictly requires NatC-mediated N-terminal acetylation of Arl3.	natc	146-150	Arf family GTPase ARL3	Saccharomyces cerevisiae S288C	186-190
23583191-9	2013	MMP-2 was found to be inhibited more with doxycycline if NaTC is present in the formulation.	natc	57-61	matrix metallopeptidase 2	Homo sapiens	0-5
23617462-2	2013	The bile salts that contain a conjugated amino acid (NaTC and NaGDC) were considerably more efficient at displacing both WPC and SCN proteins from the emulsion droplet interface, even though they are known to have a hydrophobicity lower than that of NaC and NaDC.	natc	53-57	synuclein alpha	Homo sapiens	250-253
22990529-3	2013	We analyzed the expression of IL-17A during the pathogenesis of ANP in vivo induced by 3 % sodium taurocholate (NaTc), by microarray test, quantitative real-time PCR, Western blotting, enzyme-linked immunosorbent assay, and immunohistochemistry.	natc	112-116	interleukin 17A	Rattus norvegicus	30-36
19202195-5	2009	In this study, we analyzed apoA-I binding and NaTC-dependent lipid efflux by ABCA1.	natc	46-50	ATP binding cassette subfamily A member 1	Homo sapiens	77-82
19202195-6	2009	ABCA1 mediated the efflux of cholesterol and phospholipids in the presence of NaTC as well as in the presence of apoA-I in an ATP-dependent manner.	natc	78-82	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
19202195-7	2009	The Tangier disease mutation W590S, which resides in the extracellular domain and impairs apoA-I-dependent lipid efflux, greatly decreased NaTC-dependent cholesterol and phospholipid efflux.	natc	139-143	apolipoprotein A1	Homo sapiens	90-96
15077113-3	2004	Here we show that Arl3p is not myristoylated like most members of the Arf family, but is instead amino-terminally acetylated by the NatC complex.	natc	132-136	ADP ribosylation factor like GTPase 3	Homo sapiens	18-23
15464833-7	2004	In conclusion, the permeability of insulin was increased across Caco-2 cell monolayer when the liposome sodium taurocholate (NaTC) formulation was used.	natc	125-129	insulin	Homo sapiens	35-42
11699836-8	2001	When the effect of sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC) was studied, it was found that an insulin suppository containing 100 mg of either NaTC or NaTDC produced an RH equivalent to that produced previouslY with a mixture of NaDC (100 mg) and NaC (50 mg).	natc	40-44	insulin	Canis lupus familiaris	117-124
11790502-7	2002	It was demonstrated that NaTC (present in FASSIF) had a P-gp inhibitory activity, as inclusion of NaTC in the apical compartment resulted in an increased absorptive and decreased secretory transport of CsA.	natc	25-29	phosphoglycolate phosphatase	Homo sapiens	56-60
12356421-1	2002	The effects of sodium taurocholate (NaTC) on the absorption of inhaled insulin was investigated using both in vivo and in vitro experiments.	natc	36-40	insulin	Homo sapiens	71-78
12356421-4	2002	In a similar concentration interval (20-25 mM) NaTC decreased the transepithelial electrical resistance (TEER) across Caco-2 cell monolayers leading to an increased permeability of insulin.	natc	47-51	insulin	Homo sapiens	181-188
12356421-6	2002	Furthermore, we show that NaTC in the concentration range 2-15 mM gradually decreases the aggregation state of insulin, i.e., produces mono- or dimeric insulin from hexameric insulin.	natc	26-30	insulin	Homo sapiens	111-118
12356421-6	2002	Furthermore, we show that NaTC in the concentration range 2-15 mM gradually decreases the aggregation state of insulin, i.e., produces mono- or dimeric insulin from hexameric insulin.	natc	26-30	insulin	Homo sapiens	152-159
12356421-6	2002	Furthermore, we show that NaTC in the concentration range 2-15 mM gradually decreases the aggregation state of insulin, i.e., produces mono- or dimeric insulin from hexameric insulin.	natc	26-30	insulin	Homo sapiens	152-159
12356421-7	2002	In conclusion, NaTC increases the bioavailability of nebulized insulin, increases the permeability of insulin across Caco-2 cell monolayers, and decreases the aggregation state of insulin at similar concentrations.	natc	15-19	insulin	Homo sapiens	63-70
12356421-7	2002	In conclusion, NaTC increases the bioavailability of nebulized insulin, increases the permeability of insulin across Caco-2 cell monolayers, and decreases the aggregation state of insulin at similar concentrations.	natc	15-19	insulin	Homo sapiens	102-109
12356421-7	2002	In conclusion, NaTC increases the bioavailability of nebulized insulin, increases the permeability of insulin across Caco-2 cell monolayers, and decreases the aggregation state of insulin at similar concentrations.	natc	15-19	insulin	Homo sapiens	102-109
12356421-8	2002	We suggest that the main mechanisms behind the absorption enhancement of inhaled insulin by NaTC are the production of insulin monomers and an opening of tight junctions between adjacent airway epithelial cells.	natc	92-96	insulin	Homo sapiens	81-88
12356421-8	2002	We suggest that the main mechanisms behind the absorption enhancement of inhaled insulin by NaTC are the production of insulin monomers and an opening of tight junctions between adjacent airway epithelial cells.	natc	92-96	insulin	Homo sapiens	119-126
11699836-8	2001	When the effect of sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC) was studied, it was found that an insulin suppository containing 100 mg of either NaTC or NaTDC produced an RH equivalent to that produced previouslY with a mixture of NaDC (100 mg) and NaC (50 mg).	natc	165-169	insulin	Canis lupus familiaris	117-124
3734584-8	1986	Amiloride caused intracellular acidification, and the reduction of pHi by amiloride was enhanced in the presence of NaTC, although this enhancement is difficult to interpret because of the large effects of amiloride on pHi relative to those of NaTC.	natc	116-120	glucose-6-phosphate isomerase	Rattus norvegicus	67-70
3734584-8	1986	Amiloride caused intracellular acidification, and the reduction of pHi by amiloride was enhanced in the presence of NaTC, although this enhancement is difficult to interpret because of the large effects of amiloride on pHi relative to those of NaTC.	natc	116-120	glucose-6-phosphate isomerase	Rattus norvegicus	219-222
9299086-7	1997	The effect of NaTC is greatest for lysozyme, inducing a higher degree of order and helicity in the enzyme structure.	natc	14-18	lysozyme	Homo sapiens	35-43