PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21436262-5 2011 Metabolic labeling of C-terminally tagged proaugurin in AtT-20 and AtT-20/PC2 cells resulted in a major 15-kDa tagged form on SDS-PAGE, which likely corresponds to the 9.7-kDa in vitro fragment, with the added tag, its linker, and posttranslational modification(s). proaugurin 42-52 minisatellite 6 hypermutable 3 Mus musculus 74-77 21436262-7 2011 Incubation of cells with the furin inhibitor nona-d-arginine resulted in impaired cleavage of proaugurin, whereas metalloprotease inhibitors did not affect proaugurin proteolysis. proaugurin 94-104 furin (paired basic amino acid cleaving enzyme) Mus musculus 29-34 21436262-8 2011 These data support the idea that proaugurin is cleaved by furin and secreted via the constitutive secretory pathway. proaugurin 33-43 furin (paired basic amino acid cleaving enzyme) Mus musculus 58-63 21436262-10 2011 Proliferation assays with three different tumor cell lines demonstrated that only furin-cleaved proaugurin could suppress cell proliferation, suggesting that proteolytic cleavage is a posttranslational requirement for proaugurin to suppress cell proliferation. proaugurin 96-106 furin (paired basic amino acid cleaving enzyme) Mus musculus 82-87 21436262-10 2011 Proliferation assays with three different tumor cell lines demonstrated that only furin-cleaved proaugurin could suppress cell proliferation, suggesting that proteolytic cleavage is a posttranslational requirement for proaugurin to suppress cell proliferation. proaugurin 218-228 furin (paired basic amino acid cleaving enzyme) Mus musculus 82-87