PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 6475100-3 1984 After three days of feeding rats with either geraniol or linalool, liver-microsomal cytochrome P-450 was increased. geraniol 45-53 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 84-100 2611961-2 1989 Initial 2H-NMR studies of the organization of the shorter chain homologues geraniol (C10), farnesol (C15), and solanesol (C45) were carried out by incorporating 2H-acetyl esters of the alcohol or the di-perdeuterome-thylated derivatives of the omega-labeled prenols into multilamellar phosphatidylcholine (PC) vesicles. geraniol 75-83 homeobox C10 Homo sapiens 85-88 4066690-6 1985 Pure isomers of head group 2H-labeled geraniol (C10) and solanesol (C45) gave rise to single splittings while farnesol (C15) gave rise to two sets of splittings due to cis-trans isomerization at the polar terminal double bond. geraniol 38-46 homeobox C10 Homo sapiens 48-51 32666288-3 2020 This study aimed to assess the possible modulatory effect of geraniol on the Akt/mTORC1 pathway in diabetes-induced nephropathy in rats compared to the standard antidiabetic drug gliclazide. geraniol 61-69 AKT serine/threonine kinase 1 Rattus norvegicus 77-80 33547564-6 2021 The deleted mutant on the yca1 gene showed high tolerance to citral and geraniol. geraniol 72-80 Ca(2+)-dependent cysteine protease MCA1 Saccharomyces cerevisiae S288C 26-30 32666288-0 2020 Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats. geraniol 0-8 phosphatase and tensin homolog Rattus norvegicus 73-77 32666288-3 2020 This study aimed to assess the possible modulatory effect of geraniol on the Akt/mTORC1 pathway in diabetes-induced nephropathy in rats compared to the standard antidiabetic drug gliclazide. geraniol 61-69 CREB regulated transcription coactivator 1 Mus musculus 81-87 32666288-0 2020 Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats. geraniol 0-8 AKT serine/threonine kinase 1 Rattus norvegicus 78-81 32666288-9 2020 The current study indicates that geraniol interfered with miRNA-21/ PTEN/AKT/mTORC1 pathway signaling that contributes largely to the progression of mesangial expansion and extracellular matrix deposition in diabetic nephropathy. geraniol 33-41 phosphatase and tensin homolog Rattus norvegicus 68-72 32666288-0 2020 Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats. geraniol 0-8 CREB regulated transcription coactivator 1 Mus musculus 82-88 32666288-9 2020 The current study indicates that geraniol interfered with miRNA-21/ PTEN/AKT/mTORC1 pathway signaling that contributes largely to the progression of mesangial expansion and extracellular matrix deposition in diabetic nephropathy. geraniol 33-41 AKT serine/threonine kinase 1 Rattus norvegicus 73-76 32666288-9 2020 The current study indicates that geraniol interfered with miRNA-21/ PTEN/AKT/mTORC1 pathway signaling that contributes largely to the progression of mesangial expansion and extracellular matrix deposition in diabetic nephropathy. geraniol 33-41 CREB regulated transcription coactivator 1 Mus musculus 77-83 32417955-0 2020 Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia-reperfusion injury. geraniol 0-8 NFE2 like bZIP transcription factor 2 Rattus norvegicus 19-24 33053761-7 2020 Geraniol treatment also activated the Keap1/Nrf2/heme oxygenase-1 (HO-1) pathway, increased antioxidant enzyme activities, modulated the PI3K/Akt/mTOR pathway, and ameliorated myocardial autophagy, inflammation, and apoptosis. geraniol 0-8 kelch like ECH associated protein 1 Homo sapiens 38-43 33053761-7 2020 Geraniol treatment also activated the Keap1/Nrf2/heme oxygenase-1 (HO-1) pathway, increased antioxidant enzyme activities, modulated the PI3K/Akt/mTOR pathway, and ameliorated myocardial autophagy, inflammation, and apoptosis. geraniol 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 33053761-7 2020 Geraniol treatment also activated the Keap1/Nrf2/heme oxygenase-1 (HO-1) pathway, increased antioxidant enzyme activities, modulated the PI3K/Akt/mTOR pathway, and ameliorated myocardial autophagy, inflammation, and apoptosis. geraniol 0-8 heme oxygenase 1 Homo sapiens 49-65 33053761-7 2020 Geraniol treatment also activated the Keap1/Nrf2/heme oxygenase-1 (HO-1) pathway, increased antioxidant enzyme activities, modulated the PI3K/Akt/mTOR pathway, and ameliorated myocardial autophagy, inflammation, and apoptosis. geraniol 0-8 heme oxygenase 1 Homo sapiens 67-71 33053761-7 2020 Geraniol treatment also activated the Keap1/Nrf2/heme oxygenase-1 (HO-1) pathway, increased antioxidant enzyme activities, modulated the PI3K/Akt/mTOR pathway, and ameliorated myocardial autophagy, inflammation, and apoptosis. geraniol 0-8 AKT serine/threonine kinase 1 Homo sapiens 142-145 33053761-7 2020 Geraniol treatment also activated the Keap1/Nrf2/heme oxygenase-1 (HO-1) pathway, increased antioxidant enzyme activities, modulated the PI3K/Akt/mTOR pathway, and ameliorated myocardial autophagy, inflammation, and apoptosis. geraniol 0-8 mechanistic target of rapamycin kinase Homo sapiens 146-150 33086902-7 2021 The IC50 dose of Geraniol decreased Bcl-2 staining significantly, but it significantly increased Bax staining and TUNEL positive cells. geraniol 17-25 BCL2 apoptosis regulator Homo sapiens 36-41 33086902-7 2021 The IC50 dose of Geraniol decreased Bcl-2 staining significantly, but it significantly increased Bax staining and TUNEL positive cells. geraniol 17-25 BCL2 associated X, apoptosis regulator Homo sapiens 97-100 32417955-0 2020 Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia-reperfusion injury. geraniol 0-8 heme oxygenase 1 Rattus norvegicus 25-29 31964529-3 2020 AtuB is a dehydrogenase enzyme responsible for citronellol and geraniol catabolism in the acyclic terpene utilization (Atu) pathway, although its structure and function have not been characterized to date. geraniol 63-71 citronellol catabolism dehydrogenase Pseudomonas aeruginosa PAO1 0-4 32590318-0 2020 Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-kappaB and MAPK signals: In vivo and in vitro studies. geraniol 0-8 thymoma viral proto-oncogene 1 Mus musculus 69-72 32590318-0 2020 Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-kappaB and MAPK signals: In vivo and in vitro studies. geraniol 0-8 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 73-82 32590318-5 2020 In this study, we discussed the anti-inflammatory effects of geraniol in IL-1beta-induced chondrocytes and the anti-cartilage degradation effects in a mouse model of destabilization of the medial meniscus (DMM). geraniol 61-69 interleukin 1 alpha Mus musculus 73-81 32590318-6 2020 In cell experiments, we found that the treatment of geraniol inhibited the expression of IL-1beta-induced PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 by western blot, qRT-PCR and immunofluorescence staining. geraniol 52-60 interleukin 1 alpha Mus musculus 89-97 32590318-6 2020 In cell experiments, we found that the treatment of geraniol inhibited the expression of IL-1beta-induced PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 by western blot, qRT-PCR and immunofluorescence staining. geraniol 52-60 cytochrome c oxidase II, mitochondrial Mus musculus 116-121 32590318-6 2020 In cell experiments, we found that the treatment of geraniol inhibited the expression of IL-1beta-induced PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 by western blot, qRT-PCR and immunofluorescence staining. geraniol 52-60 nitric oxide synthase 2, inducible Mus musculus 123-127 32590318-6 2020 In cell experiments, we found that the treatment of geraniol inhibited the expression of IL-1beta-induced PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 by western blot, qRT-PCR and immunofluorescence staining. geraniol 52-60 tumor necrosis factor Mus musculus 129-138 32590318-6 2020 In cell experiments, we found that the treatment of geraniol inhibited the expression of IL-1beta-induced PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 by western blot, qRT-PCR and immunofluorescence staining. geraniol 52-60 interleukin 6 Mus musculus 143-147 32590318-7 2020 Besides, geraniol inhibited the expression of MMP-9 and ADAMTS-5, and reversed the degradation of aggrecan and type II collagen. geraniol 9-17 matrix metallopeptidase 9 Mus musculus 46-51 32590318-7 2020 Besides, geraniol inhibited the expression of MMP-9 and ADAMTS-5, and reversed the degradation of aggrecan and type II collagen. geraniol 9-17 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) Mus musculus 56-64 32590318-8 2020 Mechanistically, we revealed that geraniol suppressed IL-1beta-stimulated PI3K/Akt/NF-kappaB and MAPK activation. geraniol 34-42 interleukin 1 alpha Mus musculus 54-62 32590318-8 2020 Mechanistically, we revealed that geraniol suppressed IL-1beta-stimulated PI3K/Akt/NF-kappaB and MAPK activation. geraniol 34-42 thymoma viral proto-oncogene 1 Mus musculus 79-82 32590318-8 2020 Mechanistically, we revealed that geraniol suppressed IL-1beta-stimulated PI3K/Akt/NF-kappaB and MAPK activation. geraniol 34-42 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 83-92 32171873-0 2020 Geraniol protects against cyclophosphamide-induced hepatotoxicity in rats: Possible role of MAPK and PPAR-gamma signaling pathways. geraniol 0-8 peroxisome proliferator-activated receptor gamma Rattus norvegicus 101-111 33274899-8 2020 Geraniol diminished the levels of TNF-alpha, NO and myeloperoxidase activity which were prompted by the CCl4 treatment. geraniol 0-8 tumor necrosis factor Rattus norvegicus 34-43 31396887-0 2020 Lipase-Catalyzed Esterification of Geraniol and Citronellol for the Synthesis of Terpenic Esters. geraniol 35-43 PAN0_003d1715 Moesziomyces antarcticus 0-6 31737917-0 2020 Inhibition of GLUT2 transporter by geraniol from Cymbopogon martinii: a novel treatment for diabetes mellitus in streptozotocin-induced diabetic rats. geraniol 35-43 solute carrier family 2 member 2 Rattus norvegicus 14-19 31737917-11 2020 In mRNA studies for 10 days, over expression of GLUT2 was prevented by geraniol. geraniol 71-79 solute carrier family 2 member 2 Rattus norvegicus 48-53 31737917-12 2020 CONCLUSIONS: Inhibition of GLUT2 by geraniol has the potential to reduce hyperglycaemia and prevent secondary complications in diabetes. geraniol 36-44 solute carrier family 2 member 2 Rattus norvegicus 27-32 33274899-11 2020 Geraniol has also increased the activity of hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the rats treated with CCl4. geraniol 0-8 catalase Rattus norvegicus 108-116 33274899-11 2020 Geraniol has also increased the activity of hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the rats treated with CCl4. geraniol 0-8 catalase Rattus norvegicus 118-121 33274899-11 2020 Geraniol has also increased the activity of hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the rats treated with CCl4. geraniol 0-8 glutathione-disulfide reductase Rattus norvegicus 124-145 33274899-11 2020 Geraniol has also increased the activity of hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the rats treated with CCl4. geraniol 0-8 glutathione-disulfide reductase Rattus norvegicus 147-149 33274899-11 2020 Geraniol has also increased the activity of hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the rats treated with CCl4. geraniol 0-8 hematopoietic prostaglandin D synthase Rattus norvegicus 152-177 33274899-11 2020 Geraniol has also increased the activity of hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPx) in the rats treated with CCl4. geraniol 0-8 hematopoietic prostaglandin D synthase Rattus norvegicus 179-182 31323527-7 2019 Esters of geraniol (3d) and adamantol (3e) proved to be highly active and selective inhibitors of hCES2, inhibiting the enzyme in the nanomolar range, whereas esters of borneol (3f) and isoborneol (3g) were more active and selective against hCES1. geraniol 10-18 carboxylesterase 2 Homo sapiens 98-103 31669719-0 2019 Geraniol targets KV1.3 ion channel and exhibits anti-inflammatory activity in vitro and in vivo. geraniol 0-8 potassium voltage-gated channel subfamily A member 3 Homo sapiens 17-22 31669719-4 2019 Our electrophysiological analysis determined that monoterpenes (geraniol, nerol, beta-citronellol, citral and linalool) have inhibitory effects on KV1.3 ion channel. geraniol 64-72 potassium voltage-gated channel subfamily A member 3 Homo sapiens 147-152 31669719-5 2019 Representatively, geraniol reversibly blocked KV1.3 currents in a voltage-dependent manner with an IC50 of 490.50 +- 1.04 muM at +40 mV in HEK293T cells. geraniol 18-26 potassium voltage-gated channel subfamily A member 3 Homo sapiens 46-51 31669719-6 2019 At the effective concentrations, geraniol also inhibited cytokine secretion of activated human T cells, including IL-2, TNF-alpha and IFN-gamma. geraniol 33-41 interleukin 2 Homo sapiens 114-118 31669719-6 2019 At the effective concentrations, geraniol also inhibited cytokine secretion of activated human T cells, including IL-2, TNF-alpha and IFN-gamma. geraniol 33-41 tumor necrosis factor Homo sapiens 120-129 31669719-6 2019 At the effective concentrations, geraniol also inhibited cytokine secretion of activated human T cells, including IL-2, TNF-alpha and IFN-gamma. geraniol 33-41 interferon gamma Homo sapiens 134-143 31669719-8 2019 Together, our findings not only suggest that monoterpenes may serve as lead molecules for the development of KV1.3 inhibitors, but also indicate that geraniol could be considered as a promising therapeutic candidate to treat autoimmune diseases. geraniol 150-158 potassium voltage-gated channel subfamily A member 3 Homo sapiens 109-114 31323527-7 2019 Esters of geraniol (3d) and adamantol (3e) proved to be highly active and selective inhibitors of hCES2, inhibiting the enzyme in the nanomolar range, whereas esters of borneol (3f) and isoborneol (3g) were more active and selective against hCES1. geraniol 10-18 carboxylesterase 1 Homo sapiens 241-246 31047895-0 2019 Thymoquinone and geraniol alleviate cisplatin-induced neurotoxicity in rats through downregulating the p38 MAPK/STAT-1 pathway and oxidative stress. geraniol 17-25 signal transducer and activator of transcription 1 Rattus norvegicus 112-118 31000033-2 2019 For HxAc and HpAc, the binding of SPI and the flavors decreased in the order nature > 80 C > 90 C > 100 C PSPI, for LiFo, LiAc, geraniol, and linalool, nature < 80 C < 90 C < 100 C PSPI. geraniol 140-148 chromogranin A Homo sapiens 34-37 31047895-5 2019 KEY FINDINGS: Our results demonstrated that simultaneous treatment with either TQ or Ger and CP significantly abrogated oxidative stress and downregulated the apoptotic markers p38 mitogen-activated protein kinase (MAPK), STAT-1, p53, p21 and MMP9; FMO3, however, was insignificantly decreased. geraniol 85-88 mitogen activated protein kinase 14 Rattus norvegicus 177-213 31047895-5 2019 KEY FINDINGS: Our results demonstrated that simultaneous treatment with either TQ or Ger and CP significantly abrogated oxidative stress and downregulated the apoptotic markers p38 mitogen-activated protein kinase (MAPK), STAT-1, p53, p21 and MMP9; FMO3, however, was insignificantly decreased. geraniol 85-88 signal transducer and activator of transcription 1 Rattus norvegicus 222-228 31047895-5 2019 KEY FINDINGS: Our results demonstrated that simultaneous treatment with either TQ or Ger and CP significantly abrogated oxidative stress and downregulated the apoptotic markers p38 mitogen-activated protein kinase (MAPK), STAT-1, p53, p21 and MMP9; FMO3, however, was insignificantly decreased. geraniol 85-88 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 230-233 31047895-5 2019 KEY FINDINGS: Our results demonstrated that simultaneous treatment with either TQ or Ger and CP significantly abrogated oxidative stress and downregulated the apoptotic markers p38 mitogen-activated protein kinase (MAPK), STAT-1, p53, p21 and MMP9; FMO3, however, was insignificantly decreased. geraniol 85-88 KRAS proto-oncogene, GTPase Rattus norvegicus 235-238 31047895-5 2019 KEY FINDINGS: Our results demonstrated that simultaneous treatment with either TQ or Ger and CP significantly abrogated oxidative stress and downregulated the apoptotic markers p38 mitogen-activated protein kinase (MAPK), STAT-1, p53, p21 and MMP9; FMO3, however, was insignificantly decreased. geraniol 85-88 matrix metallopeptidase 9 Rattus norvegicus 243-247 31047895-5 2019 KEY FINDINGS: Our results demonstrated that simultaneous treatment with either TQ or Ger and CP significantly abrogated oxidative stress and downregulated the apoptotic markers p38 mitogen-activated protein kinase (MAPK), STAT-1, p53, p21 and MMP9; FMO3, however, was insignificantly decreased. geraniol 85-88 flavin containing dimethylaniline monoxygenase 3 Rattus norvegicus 249-253 30506710-6 2019 We also detected a lower expression level of Bcl-2 and upregulation of BAX and caspase in the presence of geraniol and lupeol. geraniol 106-114 BCL2 apoptosis regulator Homo sapiens 45-50 31186357-5 2019 We first established a lower IPA pathway for the conversion of IPAs to isoprenoid pyrophosphate intermediates that enabled the production of greater than 2 g/L geraniol from prenol as well as limonene, farnesol, diaponeurosporene, and lycopene. geraniol 160-168 hypoxia inducible factor 3 subunit alpha Homo sapiens 63-67 31005848-4 2019 We here evaluated the potential beneficial effect of geraniol or vitamin C supplementation, natural compounds with anti-inflammatory and anti-oxidant properties, in reverse fructose-induced Mrp2 alterations. geraniol 53-61 ATP binding cassette subfamily C member 2 Rattus norvegicus 190-194 31005848-6 2019 Decreased expression of Mrp2 protein and mRNA due to fructose administration was reversed by geraniol and by vitamin C, consistent with restoration of Mrp2 activity evaluated in everted intestinal sacs. geraniol 93-101 ATP binding cassette subfamily C member 2 Rattus norvegicus 24-28 31005848-7 2019 Concomitantly, increased intestinal IL-1beta and IL-6 levels induced by fructose were totally and partially counterbalanced, respectively, by geraniol administration. geraniol 142-150 interleukin 1 alpha Rattus norvegicus 36-44 31005848-7 2019 Concomitantly, increased intestinal IL-1beta and IL-6 levels induced by fructose were totally and partially counterbalanced, respectively, by geraniol administration. geraniol 142-150 interleukin 6 Rattus norvegicus 49-53 31005848-9 2019 The restoration effects exhibited by geraniol and vitamin C suggest that local inflammatory response and OS generated under MetS-like conditions represent important mediators of the intestinal Mrp2 down-regulation. geraniol 37-45 ATP binding cassette subfamily C member 2 Rattus norvegicus 193-197 30506710-6 2019 We also detected a lower expression level of Bcl-2 and upregulation of BAX and caspase in the presence of geraniol and lupeol. geraniol 106-114 BCL2 associated X, apoptosis regulator Homo sapiens 71-74 30506710-7 2019 RESULTS: Furthermore, geraniol or lupeol also altered the phosphorylation level of extracellular signal-regulated protein kinase, P38, and c-Jun NH2-terminal kinases, suggesting involvement in mitogen-activated protein kinase signaling. geraniol 22-30 mitogen-activated protein kinase 14 Homo sapiens 130-133 30506710-7 2019 RESULTS: Furthermore, geraniol or lupeol also altered the phosphorylation level of extracellular signal-regulated protein kinase, P38, and c-Jun NH2-terminal kinases, suggesting involvement in mitogen-activated protein kinase signaling. geraniol 22-30 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 139-144 30318983-3 2019 The exposure of larvae to geraniol showed a dose dependent decrease in the activity of beta-galactosidase, tissue damage and oxidative stress markers. geraniol 26-34 beta galactosidase Drosophila melanogaster 87-105 30832389-6 2019 Moreover, relevant geraniol amounts were detected in the cerebrospinal fluid following the G-CS-OA-2% nasal administration (AUC values in the cerebrospinal fluid were 10,778 +- 477 microg mL-1 min and 5571 +- 290 microg mL-1 min after nasal administration of 4 mg/kg or 1 mg/kg, respectively). geraniol 19-27 L1 cell adhesion molecule Mus musculus 188-192 30832389-6 2019 Moreover, relevant geraniol amounts were detected in the cerebrospinal fluid following the G-CS-OA-2% nasal administration (AUC values in the cerebrospinal fluid were 10,778 +- 477 microg mL-1 min and 5571 +- 290 microg mL-1 min after nasal administration of 4 mg/kg or 1 mg/kg, respectively). geraniol 19-27 L1 cell adhesion molecule Mus musculus 220-224 30550845-0 2019 Geraniol protects against lipopolysaccharide and D-galactosamine-induced fulminant hepatic failure by activating PPARgamma. geraniol 0-8 peroxisome proliferator activated receptor gamma Mus musculus 113-122 30984275-7 2019 Interestingly, when using a lower concentration of nerol (30 muM), it was not possible to clearly observe any significant ECG signal alterations but a small reduction of ventricular contractility was observed. geraniol 51-56 latexin Homo sapiens 61-64 30984275-8 2019 In addition, 300 muM nerol promoted a significant decrease on the cardiac rate and contractility. geraniol 21-26 latexin Homo sapiens 17-20 30984275-9 2019 Important to note is the fact that in isolated cardiomyocytes, peak ICa,L was reduced by 58.9 +- 6.31% after perfusing 300 muM nerol (n=7, p<0.05). geraniol 127-132 latexin Homo sapiens 123-126 30984275-10 2019 Nerol, at 30 and 300 muM, delayed the time of onset of ouabain-triggered arrhythmias and provoked a decrease in the diastolic tension induced by the presence of ouabain (50 muM). geraniol 0-5 latexin Homo sapiens 21-24 30984275-10 2019 Nerol, at 30 and 300 muM, delayed the time of onset of ouabain-triggered arrhythmias and provoked a decrease in the diastolic tension induced by the presence of ouabain (50 muM). geraniol 0-5 latexin Homo sapiens 173-176 28334550-5 2017 Treatment of SCI rats with geraniol increased NeuN-positive cells, suppressed expression of glial fibrillary acidic protein, and reduced activity of caspase-3 in the injured region. geraniol 27-35 caspase 3 Rattus norvegicus 149-158 29902782-4 2018 Furthermore, overexpression of COQ1 in the same genetic context but with a mutated farnesyl pyrophosphate synthetase (erg20 mutation K197E), results in statistically significant higher levels of linalool (above 750 mug/L), geraniol, alpha-terpineol, and the sesquiterpenes, farnesol and nerolidol (total concentration of volatile isoprenoids surpasses 1300 mug/L). geraniol 223-231 trans-hexaprenyltranstransferase Saccharomyces cerevisiae S288C 31-35 30223562-10 2018 TB-EO and geraniol at a concentration of 15 microg/mL showed prominent inhibitory activities against ACE with % of inhibition 95.4% and 92.2%, respectively, compared with that of standard inhibitor captopril (99.8%; 15 microg/mL). geraniol 10-18 angiotensin I converting enzyme Homo sapiens 101-104 30254419-4 2018 Geraniol was found to inhibit both TNF-alpha, IL-1beta and IL-6 protein and mRNA expressions at concentrations of 40, 80, 160 muM. geraniol 0-8 tumor necrosis factor Homo sapiens 35-44 30254419-4 2018 Geraniol was found to inhibit both TNF-alpha, IL-1beta and IL-6 protein and mRNA expressions at concentrations of 40, 80, 160 muM. geraniol 0-8 interleukin 1 beta Homo sapiens 46-54 30254419-4 2018 Geraniol was found to inhibit both TNF-alpha, IL-1beta and IL-6 protein and mRNA expressions at concentrations of 40, 80, 160 muM. geraniol 0-8 interleukin 6 Homo sapiens 59-63 30254419-5 2018 In OVA-induced AR models, geraniol treatment was able to suppress AR biomarkers (OVA-specific IgE and IL-1beta as well as histamine) and nasal rub scores. geraniol 26-34 interleukin 1 beta Homo sapiens 102-110 30254419-6 2018 Interestingly, p38, a member of the mitogen-activated protein kinase (MAPK) signaling family, was found to be increasingly hypophosphorylated as geraniol dose was increased. geraniol 145-153 mitogen-activated protein kinase 14 Homo sapiens 15-18 30254419-8 2018 Conclusion: Our data highlights that the anti-inflammatory properties of geraniol on AR-related markers in activated HCM-1 cells and OVA-induced AR models may be mediated through the regulation of the MAPK/NF-kappaB signaling pathway. geraniol 73-81 nuclear factor kappa B subunit 1 Homo sapiens 206-215 28817314-3 2018 Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. geraniol 137-145 hematopoietic prostaglandin D synthase Rattus norvegicus 35-60 28817314-3 2018 Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. geraniol 137-145 glutathione-disulfide reductase Rattus norvegicus 62-83 28817314-3 2018 Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. geraniol 164-172 hematopoietic prostaglandin D synthase Rattus norvegicus 35-60 28817314-3 2018 Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. geraniol 164-172 glutathione-disulfide reductase Rattus norvegicus 62-83 28334550-6 2017 Treatment of SCI rats with geraniol reduced levels of malondialdehyde and 3-nitrotyrosine, upregulated protein expression of nuclear factor-erythroid 2-related factor 2 and heme oxygenase 1, and suppressed expression of inducible nitric oxide synthase in the injured region. geraniol 27-35 NFE2 like bZIP transcription factor 2 Rattus norvegicus 125-168 28334550-6 2017 Treatment of SCI rats with geraniol reduced levels of malondialdehyde and 3-nitrotyrosine, upregulated protein expression of nuclear factor-erythroid 2-related factor 2 and heme oxygenase 1, and suppressed expression of inducible nitric oxide synthase in the injured region. geraniol 27-35 heme oxygenase 1 Rattus norvegicus 173-189 28334550-7 2017 In addition, treatment of SCI rats with geraniol downregulated protein expression of N-methyl-d-aspartate receptor 1 and reduced the number of CD68-positive cells and protein levels of TNF-alpha in the injured region. geraniol 40-48 Cd68 molecule Rattus norvegicus 143-147 28334550-7 2017 In addition, treatment of SCI rats with geraniol downregulated protein expression of N-methyl-d-aspartate receptor 1 and reduced the number of CD68-positive cells and protein levels of TNF-alpha in the injured region. geraniol 40-48 tumor necrosis factor Rattus norvegicus 185-194 28359705-0 2017 Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae. geraniol 34-42 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C 24-29 29070885-4 2017 Using a human-derived enteroendocrine L cell line, we discovered the geraniol- and citronellal-mediated stimulation of glucagon-like peptide-1 (GLP-1) secretion and elucidated the corresponding cellular downstream signaling pathways. geraniol 69-77 glucagon Homo sapiens 119-142 29070885-4 2017 Using a human-derived enteroendocrine L cell line, we discovered the geraniol- and citronellal-mediated stimulation of glucagon-like peptide-1 (GLP-1) secretion and elucidated the corresponding cellular downstream signaling pathways. geraniol 69-77 glucagon Homo sapiens 144-149 29070885-5 2017 The geraniol-stimulated GLP-1 secretion event in the enteroendocrine cell line was mediated by the olfactory-type G protein, the activation of adenylyl cyclase, increased intracellular cAMP levels, and extracellular calcium influx. geraniol 4-12 glucagon Mus musculus 24-29 29070885-7 2017 In a type 2 diabetes mellitus mouse model (db/db), oral administration of geraniol improved glucose homeostasis by increasing plasma GLP-1 and insulin levels. geraniol 74-82 glucagon Mus musculus 133-138 29070885-8 2017 This insulinotropic action of geraniol was GLP-1 receptor-mediated, and also was glucose-dependent. geraniol 30-38 glucagon-like peptide 1 receptor Mus musculus 43-57 29050341-0 2017 Geraniol alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis. geraniol 0-8 toll-like receptor 4 Mus musculus 20-23 28359705-2 2017 In our study, by manipulation of the key enzymes geraniol synthase (GES) and farnesyl diphosphate synthase (Erg20), geraniol (a valuable acyclic monoterpene alcohol) overproduction was achieved in Saccharomyces cerevisiae with truncated 3-hydroxy-3-methylglutaryl-coenzyme reductase (tHMGR) and isopentenyl diphosphate isomerase (IDI1) overexpressed. geraniol 49-57 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C 108-113 28359705-2 2017 In our study, by manipulation of the key enzymes geraniol synthase (GES) and farnesyl diphosphate synthase (Erg20), geraniol (a valuable acyclic monoterpene alcohol) overproduction was achieved in Saccharomyces cerevisiae with truncated 3-hydroxy-3-methylglutaryl-coenzyme reductase (tHMGR) and isopentenyl diphosphate isomerase (IDI1) overexpressed. geraniol 49-57 isopentenyl-diphosphate delta-isomerase IDI1 Saccharomyces cerevisiae S288C 330-334 28358702-9 2017 TNFalpha and IL6 gene expression levels were elevated in geraniol-treated groups. geraniol 57-65 tumor necrosis factor Rattus norvegicus 0-8 28105094-10 2016 Furthermore, the inflammatory response, oxidative stress, and the caspase-9 and -3 activities were significantly suppressed upon treatment with geraniol. geraniol 144-152 caspase 9 Rattus norvegicus 66-82 28358702-9 2017 TNFalpha and IL6 gene expression levels were elevated in geraniol-treated groups. geraniol 57-65 interleukin 6 Rattus norvegicus 13-16 28358702-11 2017 Our results suggest that geraniol plays a significant role during liver regeneration, which involves the elevated expression of TNFalpha and IL6 48 h after PH. geraniol 25-33 tumor necrosis factor Rattus norvegicus 128-136 28358702-11 2017 Our results suggest that geraniol plays a significant role during liver regeneration, which involves the elevated expression of TNFalpha and IL6 48 h after PH. geraniol 25-33 interleukin 6 Rattus norvegicus 141-144 28137282-5 2017 The deletion of OYE2 (encoding an NADPH oxidoreductase) or ATF1 (encoding an alcohol acetyltransferase) both involving endogenous conversion of geraniol to other terpenoids, improved geraniol production by 1.7-fold or 1.6-fold in batch fermentation, respectively. geraniol 144-152 alcohol O-acetyltransferase Saccharomyces cerevisiae S288C 59-63 28137282-5 2017 The deletion of OYE2 (encoding an NADPH oxidoreductase) or ATF1 (encoding an alcohol acetyltransferase) both involving endogenous conversion of geraniol to other terpenoids, improved geraniol production by 1.7-fold or 1.6-fold in batch fermentation, respectively. geraniol 183-191 NADPH dehydrogenase Saccharomyces cerevisiae S288C 16-20 28137282-5 2017 The deletion of OYE2 (encoding an NADPH oxidoreductase) or ATF1 (encoding an alcohol acetyltransferase) both involving endogenous conversion of geraniol to other terpenoids, improved geraniol production by 1.7-fold or 1.6-fold in batch fermentation, respectively. geraniol 183-191 alcohol O-acetyltransferase Saccharomyces cerevisiae S288C 59-63 28137282-7 2017 Therefore, we explored dynamic control of ERG20 expression to redistribute the precursor geranyl diphosphate flux and achieved a 3.4-fold increase in geraniol production after optimizing carbon source feeding. geraniol 150-158 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C 42-47 28137282-8 2017 Furthermore, the combination of dynamic control of ERG20 expression and OYE2 deletion in LEU2 prototrophic strain increased geraniol production up to 1.69 g/L with pure ethanol feeding in fed-batch fermentation, which is the highest reported production in engineered yeast. geraniol 124-132 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C 51-56 28137282-8 2017 Furthermore, the combination of dynamic control of ERG20 expression and OYE2 deletion in LEU2 prototrophic strain increased geraniol production up to 1.69 g/L with pure ethanol feeding in fed-batch fermentation, which is the highest reported production in engineered yeast. geraniol 124-132 NADPH dehydrogenase Saccharomyces cerevisiae S288C 72-76 28137282-8 2017 Furthermore, the combination of dynamic control of ERG20 expression and OYE2 deletion in LEU2 prototrophic strain increased geraniol production up to 1.69 g/L with pure ethanol feeding in fed-batch fermentation, which is the highest reported production in engineered yeast. geraniol 124-132 3-isopropylmalate dehydrogenase Saccharomyces cerevisiae S288C 89-93 28137282-0 2017 Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae. geraniol 127-135 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C 19-24 28137282-5 2017 The deletion of OYE2 (encoding an NADPH oxidoreductase) or ATF1 (encoding an alcohol acetyltransferase) both involving endogenous conversion of geraniol to other terpenoids, improved geraniol production by 1.7-fold or 1.6-fold in batch fermentation, respectively. geraniol 144-152 NADPH dehydrogenase Saccharomyces cerevisiae S288C 16-20 26695085-4 2016 RESULTS: Treatment with geraniol reduced histological scores, fibrosis, and apoptosis in livers, lowered activities of alanine aminotransferase and aspartate aminotransferase in serum, and attenuated hepatic fat accumulation in rats fed with MCD diet. geraniol 24-32 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 148-174 27683099-0 2016 Geraniol suppresses prostate cancer growth through down-regulation of E2F8. geraniol 0-8 E2F transcription factor 8 Mus musculus 70-74 27683099-5 2016 Master regulator analysis using the prostate cancer-specific regulatory interactome identified that the transcription factor E2F8 as a specific target molecule regulates geraniol-specific cell cycle signatures. geraniol 170-178 E2F transcription factor 8 Mus musculus 125-129 27683099-6 2016 Subsequent experiments confirmed that geraniol down-regulated E2F8 expression and the knockdown of E2F8 was sufficient to suppress cell growth by inducing G2 /M arrest. geraniol 38-46 E2F transcription factor 8 Mus musculus 62-66 26695085-6 2016 Treatment with geraniol reduced uncoupling protein 2 protein expression, and enhanced protein expression of prohibitin, mRNA expression of peroxisome proliferator-activated receptor alpha, and activity of mitochondrial carnitine palmitoyl transferase-I in livers of rats fed with MCD diet. geraniol 15-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 139-187 26695085-7 2016 Treatment with geraniol abated oxidative stress, evidenced by reduced malondialdehyde and 3-nitrotyrosine formation, enhanced activity of glutathione S-epoxide transferase, and down-regulated expression of inducible nitric oxide synthase and cytochrome P450 2E1 in livers of rats fed with MCD diet. geraniol 15-23 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 242-261 28163957-8 2017 However, hepatic catalase (CAT) activities were significantly higher in H2O2, geraniol, and geraniol+H2O2 groups than control group. geraniol 78-86 catalase Rattus norvegicus 27-30 28163957-8 2017 However, hepatic catalase (CAT) activities were significantly higher in H2O2, geraniol, and geraniol+H2O2 groups than control group. geraniol 92-100 catalase Rattus norvegicus 27-30 28163957-13 2017 Geraniol can partly restore oxidative hepatic damage because it cannot completely reverse the H2O2-induced increase in hepatic CAT activities. geraniol 0-8 catalase Rattus norvegicus 127-130 26695085-6 2016 Treatment with geraniol reduced uncoupling protein 2 protein expression, and enhanced protein expression of prohibitin, mRNA expression of peroxisome proliferator-activated receptor alpha, and activity of mitochondrial carnitine palmitoyl transferase-I in livers of rats fed with MCD diet. geraniol 15-23 uncoupling protein 2 Rattus norvegicus 32-52 26695085-8 2016 Treatment with geraniol reduced myeloperoxidase activity and protein expression of tumor necrosis factor alpha and IL-6 in livers of rats fed with MCD diet. geraniol 15-23 myeloperoxidase Rattus norvegicus 32-47 26695085-8 2016 Treatment with geraniol reduced myeloperoxidase activity and protein expression of tumor necrosis factor alpha and IL-6 in livers of rats fed with MCD diet. geraniol 15-23 tumor necrosis factor Rattus norvegicus 83-110 26695085-6 2016 Treatment with geraniol reduced uncoupling protein 2 protein expression, and enhanced protein expression of prohibitin, mRNA expression of peroxisome proliferator-activated receptor alpha, and activity of mitochondrial carnitine palmitoyl transferase-I in livers of rats fed with MCD diet. geraniol 15-23 prohibitin 1 Rattus norvegicus 108-118 26695085-8 2016 Treatment with geraniol reduced myeloperoxidase activity and protein expression of tumor necrosis factor alpha and IL-6 in livers of rats fed with MCD diet. geraniol 15-23 interleukin 6 Rattus norvegicus 115-119 27117312-0 2016 Effect of treatment with geraniol on ovalbumin-induced allergic asthma in mice. geraniol 25-33 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 37-46 27117312-4 2016 RESULTS: Treatment of ovalbumin-sensitized/challenged mice with geraniol significantly decreased airway hyperresponsiveness to inhaled methacholine. geraniol 64-72 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 22-31 27117312-5 2016 Geraniol treatment reduced eotaxin levels in bronchoalveolar lavage fluid and attenuated infiltration of eosinophils induced by ovalbumin. geraniol 0-8 chemokine (C-C motif) ligand 11 Mus musculus 27-34 27117312-5 2016 Geraniol treatment reduced eotaxin levels in bronchoalveolar lavage fluid and attenuated infiltration of eosinophils induced by ovalbumin. geraniol 0-8 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 128-137 27117312-6 2016 Geraniol treatment reduced TH2 cytokines (including interleukins 4, 5, and 13), increased TH1 cytokine interferon gamma in bronchoalveolar lavage fluid, and reduced ovalbumin-specific IgE in serum. geraniol 0-8 heart and neural crest derivatives expressed 2 Mus musculus 27-30 27117312-6 2016 Geraniol treatment reduced TH2 cytokines (including interleukins 4, 5, and 13), increased TH1 cytokine interferon gamma in bronchoalveolar lavage fluid, and reduced ovalbumin-specific IgE in serum. geraniol 0-8 negative elongation factor complex member C/D, Th1l Mus musculus 90-93 27117312-6 2016 Geraniol treatment reduced TH2 cytokines (including interleukins 4, 5, and 13), increased TH1 cytokine interferon gamma in bronchoalveolar lavage fluid, and reduced ovalbumin-specific IgE in serum. geraniol 0-8 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 165-174 27117312-7 2016 In addition, treatment of ovalbumin-sensitized/challenged mice with geraniol enhanced T-bet (TH1 response) messenger RNA expression and reduced GATA-3 (TH2 response) messenger RNA expression in lungs. geraniol 68-76 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 26-35 27117312-7 2016 In addition, treatment of ovalbumin-sensitized/challenged mice with geraniol enhanced T-bet (TH1 response) messenger RNA expression and reduced GATA-3 (TH2 response) messenger RNA expression in lungs. geraniol 68-76 negative elongation factor complex member C/D, Th1l Mus musculus 93-96 27117312-7 2016 In addition, treatment of ovalbumin-sensitized/challenged mice with geraniol enhanced T-bet (TH1 response) messenger RNA expression and reduced GATA-3 (TH2 response) messenger RNA expression in lungs. geraniol 68-76 GATA binding protein 3 Mus musculus 144-150 27117312-7 2016 In addition, treatment of ovalbumin-sensitized/challenged mice with geraniol enhanced T-bet (TH1 response) messenger RNA expression and reduced GATA-3 (TH2 response) messenger RNA expression in lungs. geraniol 68-76 heart and neural crest derivatives expressed 2 Mus musculus 152-155 27117312-8 2016 Furthermore, treatment of ovalbumin -sensitized/challenged mice with geraniol further enhanced Nrf2 protein expression and activated Nrf2-directed antioxidant pathways, such as glutamate-cysteine ligase, superoxide dismutase, and glutathione S-transferase, and enhanced formation of reduced glutathione and reduced formation of malondialdehyde in lungs. geraniol 69-77 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 26-35 27117312-8 2016 Furthermore, treatment of ovalbumin -sensitized/challenged mice with geraniol further enhanced Nrf2 protein expression and activated Nrf2-directed antioxidant pathways, such as glutamate-cysteine ligase, superoxide dismutase, and glutathione S-transferase, and enhanced formation of reduced glutathione and reduced formation of malondialdehyde in lungs. geraniol 69-77 nuclear factor, erythroid derived 2, like 2 Mus musculus 95-99 27117312-8 2016 Furthermore, treatment of ovalbumin -sensitized/challenged mice with geraniol further enhanced Nrf2 protein expression and activated Nrf2-directed antioxidant pathways, such as glutamate-cysteine ligase, superoxide dismutase, and glutathione S-transferase, and enhanced formation of reduced glutathione and reduced formation of malondialdehyde in lungs. geraniol 69-77 nuclear factor, erythroid derived 2, like 2 Mus musculus 133-137 27117312-8 2016 Furthermore, treatment of ovalbumin -sensitized/challenged mice with geraniol further enhanced Nrf2 protein expression and activated Nrf2-directed antioxidant pathways, such as glutamate-cysteine ligase, superoxide dismutase, and glutathione S-transferase, and enhanced formation of reduced glutathione and reduced formation of malondialdehyde in lungs. geraniol 69-77 hematopoietic prostaglandin D synthase Mus musculus 230-255 27117312-9 2016 CONCLUSION: Geraniol attenuated important features of allergic asthma in mice, possibly through the modulation of TH1/TH2 balance and activation the of Nrf2/antioxidant response element pathway. geraniol 12-20 negative elongation factor complex member C/D, Th1l Mus musculus 114-117 27117312-9 2016 CONCLUSION: Geraniol attenuated important features of allergic asthma in mice, possibly through the modulation of TH1/TH2 balance and activation the of Nrf2/antioxidant response element pathway. geraniol 12-20 heart and neural crest derivatives expressed 2 Mus musculus 118-121 27117312-9 2016 CONCLUSION: Geraniol attenuated important features of allergic asthma in mice, possibly through the modulation of TH1/TH2 balance and activation the of Nrf2/antioxidant response element pathway. geraniol 12-20 nuclear factor, erythroid derived 2, like 2 Mus musculus 152-156 27107694-0 2016 Geraniol improves endothelial function by inhibiting NOX-2 derived oxidative stress in high fat diet fed mice. geraniol 0-8 cytochrome b-245, beta polypeptide Mus musculus 53-58 27107694-7 2016 Geraniol improved endothelial function in HFD fed mice, as evidenced by its: 1. restoring endothelial dependent vasorelaxation induced by Ach, and reversing increased VCAM-1 and ICAM-1 expression; 2. attenuating HFD induced increased serum TBARS and aortic ROS generation; and 3. downregulating aortic NOX-2 expression in both HFD fed mice and in palmitic acid treated endothelial cells. geraniol 0-8 vascular cell adhesion molecule 1 Mus musculus 167-173 27107694-8 2016 Geraniol therefore protects against endothelial dysfunction induced by HFD through reducing NOX-2 associated ROS generation. geraniol 0-8 cytochrome b-245, beta polypeptide Mus musculus 92-97 27107694-7 2016 Geraniol improved endothelial function in HFD fed mice, as evidenced by its: 1. restoring endothelial dependent vasorelaxation induced by Ach, and reversing increased VCAM-1 and ICAM-1 expression; 2. attenuating HFD induced increased serum TBARS and aortic ROS generation; and 3. downregulating aortic NOX-2 expression in both HFD fed mice and in palmitic acid treated endothelial cells. geraniol 0-8 intercellular adhesion molecule 1 Mus musculus 178-184 27107694-7 2016 Geraniol improved endothelial function in HFD fed mice, as evidenced by its: 1. restoring endothelial dependent vasorelaxation induced by Ach, and reversing increased VCAM-1 and ICAM-1 expression; 2. attenuating HFD induced increased serum TBARS and aortic ROS generation; and 3. downregulating aortic NOX-2 expression in both HFD fed mice and in palmitic acid treated endothelial cells. geraniol 0-8 cytochrome b-245, beta polypeptide Mus musculus 302-307 25618865-6 2015 We were able to capture the overall functional differences between the two conditions at the metabolic level and predict an important activity for the fluorobenzoate degradation pathway in CN1 and for geraniol metabolism in CN2. geraniol 201-209 5'-nucleotidase, cytosolic IA Homo sapiens 189-192 26883346-6 2016 The results showed that overexpressing ERG20 (WW) and strengthening the mevalonate pathway significantly improved geraniol production, while expressing heterologous GPP synthase genes or down-regulating endogenous ERG20 expression did not show positive effect. geraniol 114-122 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C 39-44 26004525-0 2015 Geraniol attenuates fibrosis and exerts anti-inflammatory effects on diet induced atherogenesis by NF-kappaB signaling pathway. geraniol 0-8 nuclear factor kappa B subunit 1 Homo sapiens 99-108 26190278-8 2015 The amount of pro-inflammatory cytokines, specifically TNF-alpha, IL-1beta and IL-6 and the activity of myeloperoxidase in colon tissue were significantly decreased in geraniol pre-treated mice. geraniol 168-176 tumor necrosis factor Mus musculus 55-64 26190278-8 2015 The amount of pro-inflammatory cytokines, specifically TNF-alpha, IL-1beta and IL-6 and the activity of myeloperoxidase in colon tissue were significantly decreased in geraniol pre-treated mice. geraniol 168-176 interleukin 1 beta Mus musculus 66-74 26190278-8 2015 The amount of pro-inflammatory cytokines, specifically TNF-alpha, IL-1beta and IL-6 and the activity of myeloperoxidase in colon tissue were significantly decreased in geraniol pre-treated mice. geraniol 168-176 interleukin 6 Mus musculus 79-83 26190278-8 2015 The amount of pro-inflammatory cytokines, specifically TNF-alpha, IL-1beta and IL-6 and the activity of myeloperoxidase in colon tissue were significantly decreased in geraniol pre-treated mice. geraniol 168-176 myeloperoxidase Mus musculus 104-119 26190278-9 2015 Western blot analyses revealed that geraniol interfered with NF-kappaB signaling by inhibiting NF-kappaB (p65)-DNA binding, and IkappaBalpha phosphorylation, degradation and subsequent increase in nuclear translocation. geraniol 36-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 26190278-9 2015 Western blot analyses revealed that geraniol interfered with NF-kappaB signaling by inhibiting NF-kappaB (p65)-DNA binding, and IkappaBalpha phosphorylation, degradation and subsequent increase in nuclear translocation. geraniol 36-44 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 128-140 26190278-10 2015 Moreover, the expressions of downstream target pro-inflammatory enzymes such as iNOS and COX-2 were significantly reduced by geraniol. geraniol 125-133 nitric oxide synthase 2, inducible Mus musculus 80-84 26190278-10 2015 Moreover, the expressions of downstream target pro-inflammatory enzymes such as iNOS and COX-2 were significantly reduced by geraniol. geraniol 125-133 cytochrome c oxidase II, mitochondrial Mus musculus 89-94 26165751-0 2015 Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 0-8 Wnt family member 2 Rattus norvegicus 58-61 26165751-0 2015 Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 0-8 catenin beta 1 Rattus norvegicus 62-74 26165751-0 2015 Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 0-8 mitogen activated protein kinase 14 Rattus norvegicus 76-83 26165751-0 2015 Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 0-8 peroxisome proliferator-activated receptor gamma Rattus norvegicus 99-108 26165751-5 2015 TNBS induced apoptosis and inflammatory cell infiltration, whereas geraniol curtailed these effects by diminishing the levels of caspase-3, intercellular adhesion molecule-1, and myeloperoxidase. geraniol 67-75 caspase 3 Rattus norvegicus 129-194 26165751-7 2015 In order to delve into the anti-colitic signaling pathways, geraniol inhibited the content/expression of glycogen synthase kinase (GSK)-3beta, beta-catenin, p38 mitogen activated protein kinase (p38MAPK), and nuclear factor kappa B (NFkappaB), but upregulated that of peroxisome proliferator activated receptor gamma (PPARgamma). geraniol 60-68 glycogen synthase kinase 3 beta Rattus norvegicus 105-141 26165751-7 2015 In order to delve into the anti-colitic signaling pathways, geraniol inhibited the content/expression of glycogen synthase kinase (GSK)-3beta, beta-catenin, p38 mitogen activated protein kinase (p38MAPK), and nuclear factor kappa B (NFkappaB), but upregulated that of peroxisome proliferator activated receptor gamma (PPARgamma). geraniol 60-68 catenin beta 1 Rattus norvegicus 143-155 26165751-7 2015 In order to delve into the anti-colitic signaling pathways, geraniol inhibited the content/expression of glycogen synthase kinase (GSK)-3beta, beta-catenin, p38 mitogen activated protein kinase (p38MAPK), and nuclear factor kappa B (NFkappaB), but upregulated that of peroxisome proliferator activated receptor gamma (PPARgamma). geraniol 60-68 mitogen activated protein kinase 14 Rattus norvegicus 157-193 26165751-7 2015 In order to delve into the anti-colitic signaling pathways, geraniol inhibited the content/expression of glycogen synthase kinase (GSK)-3beta, beta-catenin, p38 mitogen activated protein kinase (p38MAPK), and nuclear factor kappa B (NFkappaB), but upregulated that of peroxisome proliferator activated receptor gamma (PPARgamma). geraniol 60-68 mitogen activated protein kinase 14 Rattus norvegicus 195-202 26165751-7 2015 In order to delve into the anti-colitic signaling pathways, geraniol inhibited the content/expression of glycogen synthase kinase (GSK)-3beta, beta-catenin, p38 mitogen activated protein kinase (p38MAPK), and nuclear factor kappa B (NFkappaB), but upregulated that of peroxisome proliferator activated receptor gamma (PPARgamma). geraniol 60-68 peroxisome proliferator-activated receptor gamma Rattus norvegicus 268-316 26165751-7 2015 In order to delve into the anti-colitic signaling pathways, geraniol inhibited the content/expression of glycogen synthase kinase (GSK)-3beta, beta-catenin, p38 mitogen activated protein kinase (p38MAPK), and nuclear factor kappa B (NFkappaB), but upregulated that of peroxisome proliferator activated receptor gamma (PPARgamma). geraniol 60-68 peroxisome proliferator-activated receptor gamma Rattus norvegicus 318-327 26165751-9 2015 SIGNIFICANCE: Geraniol in the current study improved experimental colitis partly via its antioxidant, anti-inflammatory, and immunosuppressive potentials, possibly by modulating the Wnt/GSK-3beta/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 14-22 Wnt family member 2 Rattus norvegicus 182-185 26165751-9 2015 SIGNIFICANCE: Geraniol in the current study improved experimental colitis partly via its antioxidant, anti-inflammatory, and immunosuppressive potentials, possibly by modulating the Wnt/GSK-3beta/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 14-22 glycogen synthase kinase 3 beta Rattus norvegicus 186-195 26165751-9 2015 SIGNIFICANCE: Geraniol in the current study improved experimental colitis partly via its antioxidant, anti-inflammatory, and immunosuppressive potentials, possibly by modulating the Wnt/GSK-3beta/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 14-22 catenin beta 1 Rattus norvegicus 196-208 26165751-9 2015 SIGNIFICANCE: Geraniol in the current study improved experimental colitis partly via its antioxidant, anti-inflammatory, and immunosuppressive potentials, possibly by modulating the Wnt/GSK-3beta/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 14-22 mitogen activated protein kinase 14 Rattus norvegicus 210-217 26165751-9 2015 SIGNIFICANCE: Geraniol in the current study improved experimental colitis partly via its antioxidant, anti-inflammatory, and immunosuppressive potentials, possibly by modulating the Wnt/GSK-3beta/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways. geraniol 14-22 peroxisome proliferator-activated receptor gamma Rattus norvegicus 233-242 27046949-9 2016 Percentages of both PCNA- and GST-P- positive area were significantly decreased in G3 and in G4 compared to in G2 (P < 0.001, respectively), suggesting anti-hepatocarcinogenic effects of geraniol. geraniol 190-198 proliferating cell nuclear antigen Rattus norvegicus 20-24 27046949-9 2016 Percentages of both PCNA- and GST-P- positive area were significantly decreased in G3 and in G4 compared to in G2 (P < 0.001, respectively), suggesting anti-hepatocarcinogenic effects of geraniol. geraniol 190-198 glutathione S-transferase pi 1 Rattus norvegicus 30-35 26154255-0 2015 Geraniol Suppresses Angiogenesis by Downregulating Vascular Endothelial Growth Factor (VEGF)/VEGFR-2 Signaling. geraniol 0-8 vascular endothelial growth factor A Mus musculus 51-85 26154255-0 2015 Geraniol Suppresses Angiogenesis by Downregulating Vascular Endothelial Growth Factor (VEGF)/VEGFR-2 Signaling. geraniol 0-8 vascular endothelial growth factor A Mus musculus 87-91 26154255-0 2015 Geraniol Suppresses Angiogenesis by Downregulating Vascular Endothelial Growth Factor (VEGF)/VEGFR-2 Signaling. geraniol 0-8 kinase insert domain protein receptor Mus musculus 93-100 26154255-4 2015 Western blot analyses further revealed that geraniol downregulates proliferating cell nuclear antigen (PCNA) and upregulates cleaved caspase-3 (Casp-3) expression in eEND2 cells. geraniol 44-52 proliferating cell nuclear antigen Mus musculus 67-101 26154255-4 2015 Western blot analyses further revealed that geraniol downregulates proliferating cell nuclear antigen (PCNA) and upregulates cleaved caspase-3 (Casp-3) expression in eEND2 cells. geraniol 44-52 proliferating cell nuclear antigen Mus musculus 103-107 26154255-4 2015 Western blot analyses further revealed that geraniol downregulates proliferating cell nuclear antigen (PCNA) and upregulates cleaved caspase-3 (Casp-3) expression in eEND2 cells. geraniol 44-52 caspase 3 Mus musculus 133-142 26154255-4 2015 Western blot analyses further revealed that geraniol downregulates proliferating cell nuclear antigen (PCNA) and upregulates cleaved caspase-3 (Casp-3) expression in eEND2 cells. geraniol 44-52 caspase 3 Mus musculus 144-150 26154255-5 2015 Moreover, geraniol blocked vascular endothelial growth factor (VEGF)/VEGFR-2 signal transduction, resulting in a suppression of downstream AKT and ERK signaling pathways. geraniol 10-18 vascular endothelial growth factor A Mus musculus 27-61 26154255-5 2015 Moreover, geraniol blocked vascular endothelial growth factor (VEGF)/VEGFR-2 signal transduction, resulting in a suppression of downstream AKT and ERK signaling pathways. geraniol 10-18 vascular endothelial growth factor A Mus musculus 63-67 26154255-5 2015 Moreover, geraniol blocked vascular endothelial growth factor (VEGF)/VEGFR-2 signal transduction, resulting in a suppression of downstream AKT and ERK signaling pathways. geraniol 10-18 kinase insert domain protein receptor Mus musculus 69-76 26154255-5 2015 Moreover, geraniol blocked vascular endothelial growth factor (VEGF)/VEGFR-2 signal transduction, resulting in a suppression of downstream AKT and ERK signaling pathways. geraniol 10-18 thymoma viral proto-oncogene 1 Mus musculus 139-142 26154255-8 2015 Immunohistochemical analyses confirmed a decreased number of Ki67-positive cells and CD31-positive microvessels with reduced VEGFR-2 expression within geraniol-treated tumors. geraniol 151-159 kinase insert domain protein receptor Mus musculus 125-132 25618865-6 2015 We were able to capture the overall functional differences between the two conditions at the metabolic level and predict an important activity for the fluorobenzoate degradation pathway in CN1 and for geraniol metabolism in CN2. geraniol 201-209 carnosine dipeptidase 2 Homo sapiens 224-227 25679220-12 2015 Similar effects were reached by the combination of GO with PIO5; however, a potentiative interaction was noted on fasting serum insulin level, while synergistic effects were reflected as improved insulin sensitivity, as well as reduced RAGE and triglycerides. geraniol 51-53 advanced glycosylation end product-specific receptor Rattus norvegicus 236-240 24752813-4 2014 Considering the compartments of these TPS proteins and available substrates, the linalool peak induced by geraniol might be attributed to TPS5 and TPS37, both of them putatively localized in the plastids where high levels of monoterpene substrate geranyl diphosphate exist. geraniol 106-114 linalool synthase Solanum lycopersicum 138-142 25532298-9 2014 The combinations savory oil-chloramphenicol, savory oil-tetracycline and geraniol-chloramphenicol produced predominantly synergistic interactions (FIC indices in the range 0.21-0.87) and substantial reductions in the MIC values of antimicrobials against Gram-negative bacteria, the pharmacological treatment of which is very difficult nowadays. geraniol 73-81 C-C motif chemokine ligand 7 Homo sapiens 147-150 24752813-4 2014 Considering the compartments of these TPS proteins and available substrates, the linalool peak induced by geraniol might be attributed to TPS5 and TPS37, both of them putatively localized in the plastids where high levels of monoterpene substrate geranyl diphosphate exist. geraniol 106-114 (3S,6E)-nerolidol synthase 1-like Solanum lycopersicum 147-152 24831707-5 2014 NDPS1 transgenic fruits produced NPP-derived monoterpenes, including nerol, neral and geranial, while displaying reduced lycopene content. geraniol 69-74 dimethylallylcistransferase CPT1, chloroplastic Solanum lycopersicum 0-5 24768735-0 2014 Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson"s disease. geraniol 60-68 B cell leukemia/lymphoma 2 Mus musculus 30-34 24768735-0 2014 Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson"s disease. geraniol 60-68 BCL2-associated X protein Mus musculus 36-39 24161921-5 2013 The results obtained revealed that the IDI1-encoded isopentenyl diphosphate isomerase is a rate-limiting enzyme in the biosynthesis of geraniol in S. cerevisiae, and overexpression of MAF1, a negative regulator in tRNA biosynthesis, is another effective method to increase geraniol production in S. cerevisiae. geraniol 273-281 RNA polymerase III-inhibiting protein MAF1 Saccharomyces cerevisiae S288C 184-188 24337826-4 2014 Analysis of the gastric tissue of rats treated with geraniol (7.50 mg/kg) revealed that total glutathione content levels (GSH) increased and levels of myeloperoxidase (MPO) decreased in the gastric mucosa. geraniol 52-60 myeloperoxidase Rattus norvegicus 151-166 24337826-4 2014 Analysis of the gastric tissue of rats treated with geraniol (7.50 mg/kg) revealed that total glutathione content levels (GSH) increased and levels of myeloperoxidase (MPO) decreased in the gastric mucosa. geraniol 52-60 myeloperoxidase Rattus norvegicus 168-171 24337826-6 2014 The action of geraniol was mediated by the activation of defensive mucosa-protective factors such as the nitric oxide (NO) pathway, endogenous prostaglandins, increased mucus production, increased sulfhydryl compounds, antioxidant properties and the stimulation of calcitonin gene-related peptide (CGRP) release through the activation of transient receptor potential vanilloid (TRPV). geraniol 14-22 calcitonin-related polypeptide alpha Rattus norvegicus 265-296 24337826-6 2014 The action of geraniol was mediated by the activation of defensive mucosa-protective factors such as the nitric oxide (NO) pathway, endogenous prostaglandins, increased mucus production, increased sulfhydryl compounds, antioxidant properties and the stimulation of calcitonin gene-related peptide (CGRP) release through the activation of transient receptor potential vanilloid (TRPV). geraniol 14-22 calcitonin-related polypeptide alpha Rattus norvegicus 298-302 24269531-7 2014 YjgB was demonstrated to be the major one responsible for geraniol dehydrogenization. geraniol 58-66 oxidoreductase Escherichia coli 0-4 24269531-8 2014 Deletion of yjgB increased geraniol production to 129.7mg/L. geraniol 27-35 oxidoreductase Escherichia coli 12-16 24269531-9 2014 Introduction of the whole mevalonate pathway for enhanced building block synthesis from endogenously synthesized mevalonate improved geraniol production up to 182.5mg/L in the yjgB mutant after 48h of culture, which was a double of that obtained in the wild type control (96.5mg/L). geraniol 133-141 oxidoreductase Escherichia coli 176-180 24161921-5 2013 The results obtained revealed that the IDI1-encoded isopentenyl diphosphate isomerase is a rate-limiting enzyme in the biosynthesis of geraniol in S. cerevisiae, and overexpression of MAF1, a negative regulator in tRNA biosynthesis, is another effective method to increase geraniol production in S. cerevisiae. geraniol 135-143 isopentenyl-diphosphate delta-isomerase IDI1 Saccharomyces cerevisiae S288C 39-43 24161921-5 2013 The results obtained revealed that the IDI1-encoded isopentenyl diphosphate isomerase is a rate-limiting enzyme in the biosynthesis of geraniol in S. cerevisiae, and overexpression of MAF1, a negative regulator in tRNA biosynthesis, is another effective method to increase geraniol production in S. cerevisiae. geraniol 135-143 RNA polymerase III-inhibiting protein MAF1 Saccharomyces cerevisiae S288C 184-188 24161921-5 2013 The results obtained revealed that the IDI1-encoded isopentenyl diphosphate isomerase is a rate-limiting enzyme in the biosynthesis of geraniol in S. cerevisiae, and overexpression of MAF1, a negative regulator in tRNA biosynthesis, is another effective method to increase geraniol production in S. cerevisiae. geraniol 273-281 isopentenyl-diphosphate delta-isomerase IDI1 Saccharomyces cerevisiae S288C 39-43 23933465-3 2013 The first geraniol hydroxylation step has been reported to be catalyzed by cytochrome P450 enzymes such as CYP76B6 from Catharanthus roseus and CYP76C1 from Arabidopsis thaliana. geraniol 10-18 cytochrome P450, family 76, subfamily C, polypeptide 1 Arabidopsis thaliana 144-151 24103762-0 2013 Geraniol attenuates alpha-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner. geraniol 0-8 synuclein, alpha Mus musculus 20-35 24103762-3 2013 In the present study, we investigated the effect of geraniol (GE) against alpha-Syn aggregation on MPTP induced mouse model of PD in dose dependant manner. geraniol 52-60 synuclein, alpha Mus musculus 74-83 23933465-5 2013 This disproved CYP76C1 activity and led to the characterization of CYP76C4 from A. thaliana as a geraniol 9- or 8-hydroxylase. geraniol 97-105 cytochrome P450, family 76, subfamily C, polypeptide 1 Arabidopsis thaliana 15-22 23933465-5 2013 This disproved CYP76C1 activity and led to the characterization of CYP76C4 from A. thaliana as a geraniol 9- or 8-hydroxylase. geraniol 97-105 cytochrome P450, family 76, subfamily C, polypeptide 4 Arabidopsis thaliana 67-74 23499697-2 2013 The present study was aimed to analyze the effect of geraniol administration on the activity of phase I and phase II carcinogen metabolizing enzymes through the nuclear factor erythroid 2-related factor-2 (Nrf2) activation against 4-niroquinoline-1-oxide (4NQO) induced oral carcinogenesis. geraniol 53-61 NFE2 like bZIP transcription factor 2 Homo sapiens 161-204 32481130-4 2013 In the TPS-g subfamily, only one of the genes characterised for linalool synthases showed major transcript abundance in ripening berries, whereas the only geraniol synthase had a peak of expression in green berries and at the beginning of ripening, when geraniol concentration started to increase and overcome the linalool concentration. geraniol 155-163 terpene synthase Vitis vinifera 7-10 23399806-0 2013 Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-kappaB. geraniol 0-8 mitogen-activated protein kinase 14 Mus musculus 137-140 23399806-0 2013 Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-kappaB. geraniol 0-8 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 156-165 23668785-0 2013 Transcriptional and posttranscriptional inhibition of HMGCR and PC biosynthesis by geraniol in 2 Hep-G2 cell proliferation linked pathways. geraniol 83-91 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 54-59 23499697-2 2013 The present study was aimed to analyze the effect of geraniol administration on the activity of phase I and phase II carcinogen metabolizing enzymes through the nuclear factor erythroid 2-related factor-2 (Nrf2) activation against 4-niroquinoline-1-oxide (4NQO) induced oral carcinogenesis. geraniol 53-61 NFE2 like bZIP transcription factor 2 Homo sapiens 206-210 21391209-7 2011 The results obtained with up to 5 mg/L geraniol suggest a major improvement compared with previous available expression systems like Escherichia coli or yeast strains with an unmodified ERG20 gene that respectively delivered amounts in the 10 and 500 microg/L range or even a previously characterized K197E mutation that delivered amounts in the 1 mg/L range. geraniol 39-47 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Saccharomyces cerevisiae S288C 186-191 22200837-6 2012 At a molecular level, geraniol inhibited AKT signaling and activated AMPK signaling, resulting in mTOR inhibition. geraniol 22-30 AKT serine/threonine kinase 1 Homo sapiens 41-44 22200837-6 2012 At a molecular level, geraniol inhibited AKT signaling and activated AMPK signaling, resulting in mTOR inhibition. geraniol 22-30 mechanistic target of rapamycin kinase Homo sapiens 110-114 23200656-8 2013 We also demonstrated that OYE2 is the enzyme involved in geraniol to citronellol reduction. geraniol 57-65 NADPH dehydrogenase Saccharomyces cerevisiae S288C 26-30 23200656-10 2013 Moreover lab strain over-expressing OYE2 allows 87% geraniol to citronellol reduction in bioconversion experiment compared to about 50% conversion with control strain. geraniol 52-60 NADPH dehydrogenase Saccharomyces cerevisiae S288C 36-40 22715299-7 2012 Essential oils such as citral, citronellal, geranial, geraniol, and thymol were screened for their inhibitory activity on elastase produced by neutrophil, skin, and Pseudomonas aeruginosa by docking and were analyzed for their subcutaneous ADMET properties by ADME - TOX - Web server. geraniol 54-62 chymotrypsin like elastase 1 Homo sapiens 122-130 18824010-7 2008 In the present study, we used this system to investigate CYP-mediated activation of geraniol. geraniol 84-92 peptidyl-prolyl isomerase G (cyclophilin G) Mus musculus 57-60 21371438-3 2011 Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. geraniol 0-8 B cell leukemia/lymphoma 2 Mus musculus 71-76 21597168-2 2011 Citronellol and geraniol, the major components of rose oil, activated PPARalpha and gamma, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARgamma-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil. geraniol 298-306 peroxisome proliferator activated receptor gamma Homo sapiens 172-181 21597168-2 2011 Citronellol and geraniol, the major components of rose oil, activated PPARalpha and gamma, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARgamma-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil. geraniol 298-306 prostaglandin-endoperoxide synthase 2 Homo sapiens 207-212 21282739-0 2011 Geraniol rescues inflammation in cellular and animal models of mevalonate kinase deficiency. geraniol 0-8 mevalonate kinase Mus musculus 63-80 20686244-6 2010 The dose-response curves for TRPV1 activation by the essential oils revealed a rank order potency [the half-maximal effective concentration (EC(50))] of rose>palmarosa>thyme geraniol>tolu balsam, and rank order efficiency (% activity in response to 1 microM capsaicin) of tolu balsam>rose>palmarosa>thyme geraniol. geraniol 180-188 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 20686244-6 2010 The dose-response curves for TRPV1 activation by the essential oils revealed a rank order potency [the half-maximal effective concentration (EC(50))] of rose>palmarosa>thyme geraniol>tolu balsam, and rank order efficiency (% activity in response to 1 microM capsaicin) of tolu balsam>rose>palmarosa>thyme geraniol. geraniol 323-331 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 20686244-7 2010 Moreover, the dose-response curves for TRPV1 activation by citronellol (main constituent of rose oil) and geraniol (main constituent of thyme geraniol and palmarosa oils) were consistent with the potency and efficiency of each essential oil. geraniol 106-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 39-44 20686244-7 2010 Moreover, the dose-response curves for TRPV1 activation by citronellol (main constituent of rose oil) and geraniol (main constituent of thyme geraniol and palmarosa oils) were consistent with the potency and efficiency of each essential oil. geraniol 142-150 transient receptor potential cation channel subfamily V member 1 Homo sapiens 39-44 20686244-9 2010 In this first-of-its-kind study, we successfully investigated the role of some essential oils in promoting human TRPV1 activation, and also identified two monoterpenes, citronellol and geraniol, as new human TRPV1 agonists. geraniol 185-193 transient receptor potential cation channel subfamily V member 1 Homo sapiens 208-213 18824010-13 2008 It is likely that CYP1A1 and CYP3A5 are mainly responsible for the metabolic activation of geraniol in the skin, as they are expressed constitutively at significantly higher levels than CYP2B6. geraniol 91-99 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 18-24 21597168-0 2011 Citronellol and geraniol, components of rose oil, activate peroxisome proliferator-activated receptor alpha and gamma and suppress cyclooxygenase-2 expression. geraniol 16-24 peroxisome proliferator activated receptor alpha Homo sapiens 59-107 21597168-0 2011 Citronellol and geraniol, components of rose oil, activate peroxisome proliferator-activated receptor alpha and gamma and suppress cyclooxygenase-2 expression. geraniol 16-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 131-147 21597168-2 2011 Citronellol and geraniol, the major components of rose oil, activated PPARalpha and gamma, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARgamma-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil. geraniol 16-24 peroxisome proliferator activated receptor alpha Homo sapiens 70-79 21597168-2 2011 Citronellol and geraniol, the major components of rose oil, activated PPARalpha and gamma, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARgamma-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil. geraniol 16-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 118-123 21597168-2 2011 Citronellol and geraniol, the major components of rose oil, activated PPARalpha and gamma, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARgamma-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil. geraniol 16-24 peroxisome proliferator activated receptor gamma Homo sapiens 172-181 21597168-2 2011 Citronellol and geraniol, the major components of rose oil, activated PPARalpha and gamma, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARgamma-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil. geraniol 16-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 207-212 18611395-0 2008 The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity. geraniol 30-38 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 66-72 17573873-8 2007 One of these, geraniol, is present in FM I and two others, citronellol and hexyl cinnamal, in FM II, thus tested as part of the British Standard patch test series. geraniol 14-22 protein tyrosine phosphatase receptor type U Homo sapiens 38-42 17138864-10 2007 Given similar findings in this cell line and in BxPC-3 human pancreatic adenocarcinoma cells, we conclude that the chemotherapeutic isoprenoid compounds perillyl alcohol, farnesol, and geraniol invoke a p21(Cip1)- and p27(Kip1)-dependent antiproliferative mechanism in human pancreatic adenocarcinoma cells. geraniol 185-193 cyclin dependent kinase inhibitor 1A Homo sapiens 203-206 17138864-10 2007 Given similar findings in this cell line and in BxPC-3 human pancreatic adenocarcinoma cells, we conclude that the chemotherapeutic isoprenoid compounds perillyl alcohol, farnesol, and geraniol invoke a p21(Cip1)- and p27(Kip1)-dependent antiproliferative mechanism in human pancreatic adenocarcinoma cells. geraniol 185-193 cyclin dependent kinase inhibitor 1A Homo sapiens 207-211 17138864-0 2007 Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. geraniol 55-63 cyclin dependent kinase inhibitor 1A Homo sapiens 93-96 17138864-10 2007 Given similar findings in this cell line and in BxPC-3 human pancreatic adenocarcinoma cells, we conclude that the chemotherapeutic isoprenoid compounds perillyl alcohol, farnesol, and geraniol invoke a p21(Cip1)- and p27(Kip1)-dependent antiproliferative mechanism in human pancreatic adenocarcinoma cells. geraniol 185-193 interferon alpha inducible protein 27 Homo sapiens 218-221 17138864-0 2007 Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. geraniol 55-63 cyclin dependent kinase inhibitor 1A Homo sapiens 97-101 17138864-10 2007 Given similar findings in this cell line and in BxPC-3 human pancreatic adenocarcinoma cells, we conclude that the chemotherapeutic isoprenoid compounds perillyl alcohol, farnesol, and geraniol invoke a p21(Cip1)- and p27(Kip1)-dependent antiproliferative mechanism in human pancreatic adenocarcinoma cells. geraniol 185-193 cyclin dependent kinase inhibitor 1B Homo sapiens 222-226 17138864-0 2007 Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. geraniol 55-63 interferon alpha inducible protein 27 Homo sapiens 107-110 16719518-4 2006 Geraniol, linalool, methyl salicylate, benzyl alcohol, and 2-phenylethanol exhibited significant antifungal activities toward Colletorichum camelliae Massea, although cis-3-hexenol and linalool oxides showed weaker activities by comparison. geraniol 0-8 suppressor of cytokine signaling 3 Homo sapiens 167-172 17138864-0 2007 Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. geraniol 55-63 cyclin dependent kinase inhibitor 1B Homo sapiens 111-115 16332721-0 2006 Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. geraniol 13-21 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 219-235 16000717-5 2005 Disruption of moeA2 in P. aeruginosa PAO1 wild-type by insertion mutagenesis resulted in the same geraniol-minus phenotype. geraniol 98-106 molybdenum cofactor biosynthesis protein A Pseudomonas aeruginosa PAO1 14-19 16462894-4 2006 Up to 100 micromol geraniol/L inhibited the growth rate and 3-hydroxymethylglutaryl coenzyme A reductase (HMG-CoA) reductase activity of these cells. geraniol 19-27 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 106-124 16000717-6 2005 The ability to utilize geraniol was restored to the mutant by conjugative transfer of PCR-cloned wild-type moeA2 on a broad-host-range plasmid. geraniol 23-31 molybdenum cofactor biosynthesis protein A Pseudomonas aeruginosa PAO1 107-112 15374632-1 2004 We investigated on colon cancer cells the effect of geraniol on thymidylate synthase and thymidine kinase expression, two enzymes related to 5-fluorouracil cytotoxicity. geraniol 52-60 thymidylate synthetase Homo sapiens 64-84 15374632-3 2004 Geraniol (150 microM) but not 5-fluorouracil caused a 2-fold reduction of thymidylate synthase and thymidine kinase expression in cancer cells. geraniol 0-8 thymidylate synthetase Homo sapiens 74-94 12514264-8 2003 Geraniol, an acyclic monoterpene, suppressed HMG-CoA reductase synthesis by 98% and lowered mRNA levels by 66% (P < 0.05). geraniol 0-8 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 45-62 15450939-0 2004 Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. geraniol 0-8 cyclin dependent kinase 2 Homo sapiens 76-101 15450939-8 2004 Both beta-ionone and geraniol inhibited CDK 2 activity and dose-dependently decreased the expression of cyclins D1, E, and A, and CDK 2 and 4, without changing the expression of p21cip1 or p27kip1. geraniol 21-29 cyclin dependent kinase 2 Homo sapiens 40-45 15450939-8 2004 Both beta-ionone and geraniol inhibited CDK 2 activity and dose-dependently decreased the expression of cyclins D1, E, and A, and CDK 2 and 4, without changing the expression of p21cip1 or p27kip1. geraniol 21-29 cyclin D1 Homo sapiens 104-117 15450939-8 2004 Both beta-ionone and geraniol inhibited CDK 2 activity and dose-dependently decreased the expression of cyclins D1, E, and A, and CDK 2 and 4, without changing the expression of p21cip1 or p27kip1. geraniol 21-29 cyclin dependent kinase 2 Homo sapiens 130-141 15450939-8 2004 Both beta-ionone and geraniol inhibited CDK 2 activity and dose-dependently decreased the expression of cyclins D1, E, and A, and CDK 2 and 4, without changing the expression of p21cip1 or p27kip1. geraniol 21-29 cyclin dependent kinase inhibitor 1B Homo sapiens 189-196 11866100-0 2002 Geraniol-inducible glutathione S-transferase in cultured soybean cells. geraniol 0-8 glutathione S-transferase Glycine max 19-44 12530055-4 2002 After 48 hours of treatment with farnesol geraniol or perillyl alcohol, human BxPC3 pancreatic cancer cells exhibited a 3 to 10-fold increase in apoptosis and higher Bak expression than the controls. geraniol 42-50 BCL2 antagonist/killer 1 Homo sapiens 166-169 12388655-6 2002 After 16 h of incubation, geraniol decreased by 50% the amount of active forms of p44/p42 extracellular signal-regulated protein kinases (ERK). geraniol 26-34 interferon induced protein 44 Homo sapiens 82-85 12388655-6 2002 After 16 h of incubation, geraniol decreased by 50% the amount of active forms of p44/p42 extracellular signal-regulated protein kinases (ERK). geraniol 26-34 cyclin dependent kinase 20 Homo sapiens 86-89 12388655-8 2002 These results indicate that the antiproliferative effect of geraniol on Caco-2 cells was not related to a limitation of the mevalonate pool but was directly linked to the perturbation of cell membrane function leading to the reduction of PKC activity and to the decreased expression of p44/p42 ERK active forms. geraniol 60-68 interferon induced protein 44 Homo sapiens 286-289 12388655-8 2002 These results indicate that the antiproliferative effect of geraniol on Caco-2 cells was not related to a limitation of the mevalonate pool but was directly linked to the perturbation of cell membrane function leading to the reduction of PKC activity and to the decreased expression of p44/p42 ERK active forms. geraniol 60-68 cyclin dependent kinase 20 Homo sapiens 290-293 11866100-3 2002 The GST mRNA level and GST activity were elevated to maxima at 4-6 h and 8 h, respectively, after treatment of the cultures with geraniol. geraniol 129-137 glutathione S-transferase Glycine max 4-7 11866100-3 2002 The GST mRNA level and GST activity were elevated to maxima at 4-6 h and 8 h, respectively, after treatment of the cultures with geraniol. geraniol 129-137 glutathione S-transferase Glycine max 23-26 11866100-4 2002 These indicate that GST is one of the geraniol-responsive factors in soybean cells. geraniol 38-46 glutathione S-transferase Glycine max 20-23 11408542-5 2001 Geraniol caused a 50% decrease of ornithine decarboxylase activity, a key enzyme of polyamine biosynthesis, which is enhanced in cancer growth. geraniol 0-8 ornithine decarboxylase 1 Homo sapiens 34-57 9081680-6 1997 The inhibitory effect of fluvastatin on TF activity and antigen was fully reversible by coincubation with 100 mumol/L mevalonate or 10 mumol/L all-trans-geranylgeraniol but not with dolichol, farnesol, or geraniol. geraniol 160-168 coagulation factor III, tissue factor Homo sapiens 40-42 11299356-0 2001 The cyclization of farnesyl diphosphate and nerolidyl diphosphate by a purified recombinant delta-cadinene synthase. geraniol 44-65 (+)-delta-cadinene synthase Gossypium hirsutum 92-115 33826182-5 2021 Geraniol inhibits the proliferation of PC-3, A431, and A549 cells (~50%) and suppresses the activity of ornithine decarboxylase (15.42 +- 0.61 muM) and hyaluronidase (57.61 +- 8.53 muM) in A549 cells; LOX-5 (25.44 +- 3.50 muM) and hyaluronidase (90.71 +- 2.38 muM) in A431 cells. geraniol 0-8 ornithine decarboxylase 1 Homo sapiens 104-127 33826182-5 2021 Geraniol inhibits the proliferation of PC-3, A431, and A549 cells (~50%) and suppresses the activity of ornithine decarboxylase (15.42 +- 0.61 muM) and hyaluronidase (57.61 +- 8.53 muM) in A549 cells; LOX-5 (25.44 +- 3.50 muM) and hyaluronidase (90.71 +- 2.38 muM) in A431 cells. geraniol 0-8 arachidonate 5-lipoxygenase Homo sapiens 201-206 34773764-0 2022 Time trend of the exposure to geraniol in 24-h urine samples derived from the German Environmental Specimen Bank from 2004 to 2018. geraniol 30-38 B cell scaffold protein with ankyrin repeats 1 Homo sapiens 108-112 34944045-0 2021 Exploring the Binding Pattern of Geraniol with Acetylcholinesterase through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Enzyme Inhibition Kinetics Studies. geraniol 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 34944045-2 2021 Here, the inhibitory potential of geraniol and its mechanism of inhibition against AChE were elucidated in vitro and validated via an in silico study. geraniol 34-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 34944045-3 2021 Our in vitro enzyme inhibition kinetics results show that at increasing concentrations of geraniol and substrate, Vmax did not change significantly, but Km increased, which indicates that geraniol is a competitive inhibitor against AChE with an IC50 value 98.06 +- 3.92 microM. geraniol 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 34944045-3 2021 Our in vitro enzyme inhibition kinetics results show that at increasing concentrations of geraniol and substrate, Vmax did not change significantly, but Km increased, which indicates that geraniol is a competitive inhibitor against AChE with an IC50 value 98.06 +- 3.92 microM. geraniol 188-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 34944045-5 2021 A docking study showed that the binding energy of geraniol (-5.6 kcal mol-1) was lower than that of acetylcholine (-4.1 kcal mol-1) with AChE, which exhibited around a 12.58-fold higher binding affinity of geraniol. geraniol 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 34944045-5 2021 A docking study showed that the binding energy of geraniol (-5.6 kcal mol-1) was lower than that of acetylcholine (-4.1 kcal mol-1) with AChE, which exhibited around a 12.58-fold higher binding affinity of geraniol. geraniol 206-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 34944045-6 2021 Furthermore, molecular dynamics simulation revealed that the RMSD of AChE alone or in complex with geraniol fluctuated within acceptable limits throughout the simulation. geraniol 99-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 34944045-10 2021 These findings suggest that geraniol remained inside the binding cavity of AChE in a stable conformation. geraniol 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 34889889-0 2021 Geraniol Averts Methotrexate-Induced Acute Kidney Injury via Keap1/Nrf2/HO-1 and MAPK/NF-kappaB Pathways. geraniol 0-8 Kelch-like ECH-associated protein 1 Rattus norvegicus 61-66 34889889-0 2021 Geraniol Averts Methotrexate-Induced Acute Kidney Injury via Keap1/Nrf2/HO-1 and MAPK/NF-kappaB Pathways. geraniol 0-8 NFE2 like bZIP transcription factor 2 Rattus norvegicus 67-71 34889889-0 2021 Geraniol Averts Methotrexate-Induced Acute Kidney Injury via Keap1/Nrf2/HO-1 and MAPK/NF-kappaB Pathways. geraniol 0-8 heme oxygenase 1 Rattus norvegicus 72-76 35608392-0 2022 Geraniol enhances peroxiredoxin-1, and prevents isoproterenol-induced oxidative stress and inflammation associated with myocardial infarction in experimental animal models. geraniol 0-8 peroxiredoxin 1 Rattus norvegicus 18-33 35608392-1 2022 This study has explored the fact that geraniol prevents isoproterenol (ISO)-induced oxidative stress and inflammation-mediated myocardial infarction (MI) through enhanced expression of peroxiredoxin-1 (Prdx-1) in experimental animal models. geraniol 38-46 peroxiredoxin 1 Rattus norvegicus 185-200 35608392-1 2022 This study has explored the fact that geraniol prevents isoproterenol (ISO)-induced oxidative stress and inflammation-mediated myocardial infarction (MI) through enhanced expression of peroxiredoxin-1 (Prdx-1) in experimental animal models. geraniol 38-46 peroxiredoxin 1 Rattus norvegicus 202-208 35608392-6 2022 Furthermore, gene expression results revealed that geraniol treatment inhibited the mitogen-activated protein kinase (MAPK) proteins, inflammatory responder (tumor necrosis factor-alpha, interleukin 6, nuclear factor-kappaB), and cardiac fibrotic proteins (matrix metalloproteinase-2(MMP-2), MMP-9) in ISO directed rats. geraniol 51-59 interleukin 6 Rattus norvegicus 187-200 35608392-6 2022 Furthermore, gene expression results revealed that geraniol treatment inhibited the mitogen-activated protein kinase (MAPK) proteins, inflammatory responder (tumor necrosis factor-alpha, interleukin 6, nuclear factor-kappaB), and cardiac fibrotic proteins (matrix metalloproteinase-2(MMP-2), MMP-9) in ISO directed rats. geraniol 51-59 matrix metallopeptidase 2 Rattus norvegicus 257-283 35608392-6 2022 Furthermore, gene expression results revealed that geraniol treatment inhibited the mitogen-activated protein kinase (MAPK) proteins, inflammatory responder (tumor necrosis factor-alpha, interleukin 6, nuclear factor-kappaB), and cardiac fibrotic proteins (matrix metalloproteinase-2(MMP-2), MMP-9) in ISO directed rats. geraniol 51-59 matrix metallopeptidase 2 Rattus norvegicus 284-289 35608392-6 2022 Furthermore, gene expression results revealed that geraniol treatment inhibited the mitogen-activated protein kinase (MAPK) proteins, inflammatory responder (tumor necrosis factor-alpha, interleukin 6, nuclear factor-kappaB), and cardiac fibrotic proteins (matrix metalloproteinase-2(MMP-2), MMP-9) in ISO directed rats. geraniol 51-59 matrix metallopeptidase 9 Rattus norvegicus 292-297 35608392-9 2022 In this study, an elevated expression of Prdx1 was noticed in geraniol treated with ISO-directed rats. geraniol 62-70 peroxiredoxin 1 Rattus norvegicus 41-46 35608392-10 2022 Hence, we concluded that geraniol is considered a potential phytodrug, and it prevents ISO-directed MAPKs, inflammation, and cardiac markers by enhancing the expression of Prdx1. geraniol 25-33 peroxiredoxin 1 Rattus norvegicus 172-177 35517879-0 2022 Autophagy/ Apoptosis Induced by Geraniol through HIF-1alpha/BNIP3/Beclin-1 Signaling Pathway in A549 CoCl2 Treated Cells. geraniol 32-40 hypoxia inducible factor 1 subunit alpha Homo sapiens 49-59 35517879-0 2022 Autophagy/ Apoptosis Induced by Geraniol through HIF-1alpha/BNIP3/Beclin-1 Signaling Pathway in A549 CoCl2 Treated Cells. geraniol 32-40 BCL2 interacting protein 3 Homo sapiens 60-65 35517879-0 2022 Autophagy/ Apoptosis Induced by Geraniol through HIF-1alpha/BNIP3/Beclin-1 Signaling Pathway in A549 CoCl2 Treated Cells. geraniol 32-40 beclin 1 Homo sapiens 66-74 22760862-0 2013 Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis. geraniol 0-8 cytochrome c oxidase II, mitochondrial Mus musculus 58-63 22760862-0 2013 Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis. geraniol 0-8 mitogen-activated protein kinase 3 Mus musculus 80-86 34942558-0 2022 Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach. geraniol 0-8 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 66-71 34942558-8 2022 The best docking score was possessed by Geraniol and its constituent (geldanamycin >= -4.93 kcal/mol) (a known antifungal and antitumor against HSP90) in all the above species. geraniol 40-48 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 144-149 34942558-9 2022 Lemongrass oil and the combination of Geraniol and Citral at concentrations of 80 mug/mL showed the maximum inhibition of ATPase and HSP90-ATPase activity compared to their individual treatment. geraniol 38-46 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 133-138 34942558-10 2022 Therefore, both in silico and in vitro studies provide clear evidence of specific inhibitory action of lemongrass oil, Geraniol, and Citral against the ATPase and HSP90-ATPase activities and might show potential as antifungal and antitumor drugs. geraniol 119-127 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 163-168 34968469-3 2022 We aimed to evaluate if geraniol, which can modulate both PPARgamma and Wnt signaling, could protect against CsA-induced nephrotoxicity. geraniol 24-32 peroxisome proliferator-activated receptor gamma Rattus norvegicus 58-67 34968469-3 2022 We aimed to evaluate if geraniol, which can modulate both PPARgamma and Wnt signaling, could protect against CsA-induced nephrotoxicity. geraniol 24-32 Wnt family member 4 Rattus norvegicus 72-75 34968469-11 2022 SIGNIFICANCE: The down-regulation of Wnt/beta-catenin and the increase in PPARgamma by geraniol suggest that both pathways are involved in its renoprotective potential. geraniol 87-95 Wnt family member 4 Rattus norvegicus 37-40 34968469-11 2022 SIGNIFICANCE: The down-regulation of Wnt/beta-catenin and the increase in PPARgamma by geraniol suggest that both pathways are involved in its renoprotective potential. geraniol 87-95 catenin beta 1 Rattus norvegicus 41-53 34968469-11 2022 SIGNIFICANCE: The down-regulation of Wnt/beta-catenin and the increase in PPARgamma by geraniol suggest that both pathways are involved in its renoprotective potential. geraniol 87-95 peroxisome proliferator-activated receptor gamma Rattus norvegicus 74-83 34889889-3 2021 This study investigated the efficacy of geraniol to prevent methotrexate-induced acute kidney injury and via scrutinizing the Keap1/Nrf2/HO-1, P38MAPK/NF-kappaB and Bax/Bcl2/caspase-3 and -9 pathways. geraniol 40-48 BCL2 associated X, apoptosis regulator Rattus norvegicus 165-168 34889889-3 2021 This study investigated the efficacy of geraniol to prevent methotrexate-induced acute kidney injury and via scrutinizing the Keap1/Nrf2/HO-1, P38MAPK/NF-kappaB and Bax/Bcl2/caspase-3 and -9 pathways. geraniol 40-48 caspase 3 Rattus norvegicus 174-190 34889889-5 2021 RESULTS: Geraniol effectively reduced the serum levels of creatinine, urea and Kim-1 with an increase in the serum level of albumin when compared to the methotrexate-treated group. geraniol 9-17 hepatitis A virus cellular receptor 1 Rattus norvegicus 79-84 34889889-6 2021 Geraniol reduced Keap1, escalated Nrf2 and HO-1, enhanced the antioxidant parameters GSH, SOD, CAT and GSHPx and reduced MDA and NO. geraniol 0-8 Kelch-like ECH-associated protein 1 Rattus norvegicus 17-22 34889889-6 2021 Geraniol reduced Keap1, escalated Nrf2 and HO-1, enhanced the antioxidant parameters GSH, SOD, CAT and GSHPx and reduced MDA and NO. geraniol 0-8 NFE2 like bZIP transcription factor 2 Rattus norvegicus 34-38 34889889-6 2021 Geraniol reduced Keap1, escalated Nrf2 and HO-1, enhanced the antioxidant parameters GSH, SOD, CAT and GSHPx and reduced MDA and NO. geraniol 0-8 heme oxygenase 1 Rattus norvegicus 43-47 34889889-6 2021 Geraniol reduced Keap1, escalated Nrf2 and HO-1, enhanced the antioxidant parameters GSH, SOD, CAT and GSHPx and reduced MDA and NO. geraniol 0-8 catalase Rattus norvegicus 95-98 34889889-6 2021 Geraniol reduced Keap1, escalated Nrf2 and HO-1, enhanced the antioxidant parameters GSH, SOD, CAT and GSHPx and reduced MDA and NO. geraniol 0-8 glutathione peroxidase 1 Rattus norvegicus 103-108 34889889-7 2021 Geraniol decreased renal P38 MAPK and NF-kappaB and ameliorated the inflammatory mediators TNF-alpha, IL-1beta, IL-6 and IL-10. geraniol 0-8 tumor necrosis factor Rattus norvegicus 91-100 34889889-7 2021 Geraniol decreased renal P38 MAPK and NF-kappaB and ameliorated the inflammatory mediators TNF-alpha, IL-1beta, IL-6 and IL-10. geraniol 0-8 interleukin 1 alpha Rattus norvegicus 102-110 34889889-7 2021 Geraniol decreased renal P38 MAPK and NF-kappaB and ameliorated the inflammatory mediators TNF-alpha, IL-1beta, IL-6 and IL-10. geraniol 0-8 interleukin 6 Rattus norvegicus 112-116 34889889-7 2021 Geraniol decreased renal P38 MAPK and NF-kappaB and ameliorated the inflammatory mediators TNF-alpha, IL-1beta, IL-6 and IL-10. geraniol 0-8 interleukin 10 Rattus norvegicus 121-126 34889889-8 2021 Geraniol negatively regulated the apoptotic mediators Bax and caspase-3 and -9 and increased Bcl2. geraniol 0-8 BCL2 associated X, apoptosis regulator Rattus norvegicus 54-57 34889889-8 2021 Geraniol negatively regulated the apoptotic mediators Bax and caspase-3 and -9 and increased Bcl2. geraniol 0-8 caspase 3 Rattus norvegicus 62-78 34889889-8 2021 Geraniol negatively regulated the apoptotic mediators Bax and caspase-3 and -9 and increased Bcl2. geraniol 0-8 BCL2, apoptosis regulator Rattus norvegicus 93-97 34333419-3 2021 In this study, a series of structural optimizations were introduced to displace the unstable coumarin and geraniol scaffolds of auraptene (AUR), a novel and safe FXR agonist. geraniol 106-114 nuclear receptor subfamily 1 group H member 4 Homo sapiens 162-165 34075659-0 2021 Inhibiting the JNK/ERK signaling pathway with geraniol for attenuating the proliferation of human gastric adenocarcinoma AGS cells. geraniol 46-54 mitogen-activated protein kinase 8 Homo sapiens 15-18 34075659-0 2021 Inhibiting the JNK/ERK signaling pathway with geraniol for attenuating the proliferation of human gastric adenocarcinoma AGS cells. geraniol 46-54 mitogen-activated protein kinase 1 Homo sapiens 19-22 34075659-6 2021 Also, geraniol potently diminished caspase-9, Bax, Bcl-2, and caspase-3 expression in AGS cells. geraniol 6-14 caspase 9 Homo sapiens 35-44 34075659-6 2021 Also, geraniol potently diminished caspase-9, Bax, Bcl-2, and caspase-3 expression in AGS cells. geraniol 6-14 BCL2 associated X, apoptosis regulator Homo sapiens 46-49 34075659-6 2021 Also, geraniol potently diminished caspase-9, Bax, Bcl-2, and caspase-3 expression in AGS cells. geraniol 6-14 BCL2 apoptosis regulator Homo sapiens 51-56 34075659-6 2021 Also, geraniol potently diminished caspase-9, Bax, Bcl-2, and caspase-3 expression in AGS cells. geraniol 6-14 caspase 3 Homo sapiens 62-71 34075659-8 2021 Moreover, the present study depicted that geraniol-induced cell death through mitochondrial ROS production and inhibited the phosphorylation form of mitogen-activated protein kinase (p38, MAPK, JNK, and ERK1/2) signaling pathway. geraniol 42-50 mitogen-activated protein kinase 1 Homo sapiens 183-186 34075659-8 2021 Moreover, the present study depicted that geraniol-induced cell death through mitochondrial ROS production and inhibited the phosphorylation form of mitogen-activated protein kinase (p38, MAPK, JNK, and ERK1/2) signaling pathway. geraniol 42-50 mitogen-activated protein kinase 8 Homo sapiens 194-197 34075659-8 2021 Moreover, the present study depicted that geraniol-induced cell death through mitochondrial ROS production and inhibited the phosphorylation form of mitogen-activated protein kinase (p38, MAPK, JNK, and ERK1/2) signaling pathway. geraniol 42-50 mitogen-activated protein kinase 3 Homo sapiens 203-209 35458182-0 2022 Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-kappaB and Nrf2/Ho-1. geraniol 0-8 NFE2 like bZIP transcription factor 2 Rattus norvegicus 160-164 35458182-0 2022 Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-kappaB and Nrf2/Ho-1. geraniol 0-8 heme oxygenase 1 Rattus norvegicus 165-169 35312192-0 2022 Geraniol ameliorates the progression of high fat-diet/streptozotocin-induced type 2 diabetes mellitus in rats via regulation of caspase-3, Bcl-2, and Bax expression. geraniol 0-8 caspase 3 Rattus norvegicus 128-137 35312192-0 2022 Geraniol ameliorates the progression of high fat-diet/streptozotocin-induced type 2 diabetes mellitus in rats via regulation of caspase-3, Bcl-2, and Bax expression. geraniol 0-8 BCL2, apoptosis regulator Rattus norvegicus 139-144 35312192-0 2022 Geraniol ameliorates the progression of high fat-diet/streptozotocin-induced type 2 diabetes mellitus in rats via regulation of caspase-3, Bcl-2, and Bax expression. geraniol 0-8 BCL2 associated X, apoptosis regulator Rattus norvegicus 150-153 35312192-6 2022 Also, geraniol treatment prompted a significant reduction in the expression levels of caspase-3 (Casp3) and Bax mRNA. geraniol 6-14 caspase 3 Rattus norvegicus 86-95 35312192-6 2022 Also, geraniol treatment prompted a significant reduction in the expression levels of caspase-3 (Casp3) and Bax mRNA. geraniol 6-14 caspase 3 Rattus norvegicus 97-102 35312192-6 2022 Also, geraniol treatment prompted a significant reduction in the expression levels of caspase-3 (Casp3) and Bax mRNA. geraniol 6-14 BCL2 associated X, apoptosis regulator Rattus norvegicus 108-111 35312192-7 2022 In conclusion, geraniol ameliorates the progress of HFD/STZ-induced type 2 diabetes mellitus in rats via dependently upregulating the expression of Bcl-2 and downregulating Casp3 and Bax expression. geraniol 15-23 BCL2, apoptosis regulator Rattus norvegicus 148-153 35312192-7 2022 In conclusion, geraniol ameliorates the progress of HFD/STZ-induced type 2 diabetes mellitus in rats via dependently upregulating the expression of Bcl-2 and downregulating Casp3 and Bax expression. geraniol 15-23 caspase 3 Rattus norvegicus 173-178 35312192-7 2022 In conclusion, geraniol ameliorates the progress of HFD/STZ-induced type 2 diabetes mellitus in rats via dependently upregulating the expression of Bcl-2 and downregulating Casp3 and Bax expression. geraniol 15-23 BCL2 associated X, apoptosis regulator Rattus norvegicus 183-186 35203751-7 2022 Thymol, carvacrol and geraniol exhibited the best antibacterial and anti-biofilm activities against uropathogenic NDM-1-producing K. pneumoniae isolates. geraniol 22-30 NDM-1 Klebsiella pneumoniae 114-119 35517879-6 2022 Results: GE and CoCl2 combination therapy downregulated the expression of HIF-1alpha thatsuppressed A549 cell growth through downregulation of BNIP3 and beclin-1 gene expression.This resulted in autophagy and apoptotic cell death, in addition to the downregulation of NF-kBand VEGF expression. geraniol 9-11 hypoxia inducible factor 1 subunit alpha Homo sapiens 74-84 35517879-6 2022 Results: GE and CoCl2 combination therapy downregulated the expression of HIF-1alpha thatsuppressed A549 cell growth through downregulation of BNIP3 and beclin-1 gene expression.This resulted in autophagy and apoptotic cell death, in addition to the downregulation of NF-kBand VEGF expression. geraniol 9-11 BCL2 interacting protein 3 Homo sapiens 143-148 35517879-6 2022 Results: GE and CoCl2 combination therapy downregulated the expression of HIF-1alpha thatsuppressed A549 cell growth through downregulation of BNIP3 and beclin-1 gene expression.This resulted in autophagy and apoptotic cell death, in addition to the downregulation of NF-kBand VEGF expression. geraniol 9-11 beclin 1 Homo sapiens 153-161 35517879-6 2022 Results: GE and CoCl2 combination therapy downregulated the expression of HIF-1alpha thatsuppressed A549 cell growth through downregulation of BNIP3 and beclin-1 gene expression.This resulted in autophagy and apoptotic cell death, in addition to the downregulation of NF-kBand VEGF expression. geraniol 9-11 vascular endothelial growth factor A Homo sapiens 277-281