PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23144800-7	2012	Moreover, a decrease in intracellular polyamine concentrations stimulated by methylglyoxal-bis(guanylhydrazone) (MGBG) enhanced the ACTD-induced inhibition of c-myc transcription and DNA replication in several cancer cell lines.	Mitoguazone	77-111	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-164
23144800-7	2012	Moreover, a decrease in intracellular polyamine concentrations stimulated by methylglyoxal-bis(guanylhydrazone) (MGBG) enhanced the ACTD-induced inhibition of c-myc transcription and DNA replication in several cancer cell lines.	Mitoguazone	113-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-164
20515262-1	2010	The synthesis of TNF may be inhibited at the transcriptional level by antisense to either TNF or NF-kappaB or at the post-transcriptional level by CNI-1493, a guanylhydrazone compound which inhibits p38 MAP kinase activity.	Mitoguazone	159-174	tumor necrosis factor	Rattus norvegicus	17-20
20202915-6	2010	L864F pol alpha also exhibited increased translesion activity over the abasic, etheno-A, O(4)-methyl-T, and O(6)-methyl-G sites.	Mitoguazone	113-121	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	6-15
20515262-1	2010	The synthesis of TNF may be inhibited at the transcriptional level by antisense to either TNF or NF-kappaB or at the post-transcriptional level by CNI-1493, a guanylhydrazone compound which inhibits p38 MAP kinase activity.	Mitoguazone	159-174	mitogen activated protein kinase 14	Rattus norvegicus	199-202
12624752-0	2003	Polyamine oxidase activity in rats treated with mitoguazone: specific and permanent decrease in thymus.	Mitoguazone	48-59	polyamine oxidase	Rattus norvegicus	0-17
18976929-2	2008	We prepared and characterized the activity of a series of 16 guanylhydrazone small molecules that are designed to block estrogen receptor (ER) activity through a non-traditional mechanism, by directly interfering with coactivator binding to agonist-liganded ER.	Mitoguazone	61-76	estrogen receptor 1	Homo sapiens	120-137
18976929-2	2008	We prepared and characterized the activity of a series of 16 guanylhydrazone small molecules that are designed to block estrogen receptor (ER) activity through a non-traditional mechanism, by directly interfering with coactivator binding to agonist-liganded ER.	Mitoguazone	61-76	estrogen receptor 1	Homo sapiens	139-141
18976929-2	2008	We prepared and characterized the activity of a series of 16 guanylhydrazone small molecules that are designed to block estrogen receptor (ER) activity through a non-traditional mechanism, by directly interfering with coactivator binding to agonist-liganded ER.	Mitoguazone	61-76	estrogen receptor 1	Homo sapiens	258-260
21783704-6	2006	MGBG also blocks the cell cycle transition caused by gamma-radiation (G(2) arrest), which helps protect cells by allowing time for DNA repair before entry into mitosis or apoptosis, via the down regulation of cyclin D1, which mediates the transition from G(1) to S phase of cell cycle, and ataxia telangiectasia mutated, which is involved in the DNA sensing, repair and cell cycle check point.	Mitoguazone	0-4	cyclin D1	Homo sapiens	209-218
15630446-5	2005	Here, we identified the guanylhydrazone CNI-1493 as an efficient inhibitor of human deoxyhypusine synthase (DHS).	Mitoguazone	24-39	deoxyhypusine synthase	Homo sapiens	84-106
15630446-5	2005	Here, we identified the guanylhydrazone CNI-1493 as an efficient inhibitor of human deoxyhypusine synthase (DHS).	Mitoguazone	24-39	deoxyhypusine synthase	Homo sapiens	108-111
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Mitoguazone	41-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Mitoguazone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Mitoguazone	77-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255
18256853-0	2008	The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase.	Mitoguazone	4-19	PBANKA_103000	Plasmodium berghei ANKA	150-172
17314043-1	2007	The guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde, 1, with an IC(50) of 840 nM against the CCR5 receptor was identified using high-throughput screening.	Mitoguazone	4-19	C-C motif chemokine receptor 5	Homo sapiens	106-110
17081751-0	2007	CCR5 receptor antagonists: discovery and SAR study of guanylhydrazone derivatives.	Mitoguazone	54-69	C-C motif chemokine receptor 5	Homo sapiens	0-4
17081751-1	2007	High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist.	Mitoguazone	65-80	C-C motif chemokine receptor 5	Homo sapiens	131-135
17081751-4	2007	Replacement of the guanylhydrazone group led to the discovery of a novel series of CCR5 antagonists.	Mitoguazone	19-34	C-C motif chemokine receptor 5	Homo sapiens	83-87
16544571-10	2006	18 cv.seedlings with methylglyoxyl-bis (guanylhydrazone) (MGBG), an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), aggravated osmotic stress injury to this cultivar, coupled with market decreases of the NCC-Spm and NCC-Spd levels.	Mitoguazone	58-62	S-adenosylmethionine decarboxylase proenzyme	Triticum aestivum	81-115
16544571-10	2006	18 cv.seedlings with methylglyoxyl-bis (guanylhydrazone) (MGBG), an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), aggravated osmotic stress injury to this cultivar, coupled with market decreases of the NCC-Spm and NCC-Spd levels.	Mitoguazone	58-62	S-adenosylmethionine decarboxylase proenzyme	Triticum aestivum	117-122
15541750-0	2004	Effect of mitoguazone on polyamine oxidase activity in rat liver.	Mitoguazone	10-21	polyamine oxidase	Rattus norvegicus	25-42
15541750-5	2004	Mitoguazone administration induced hepatic polyamine oxidase activity starting at 4 h after administration, and the enzyme returned to basal levels 96 h after treatment.	Mitoguazone	0-11	polyamine oxidase	Rattus norvegicus	43-60
15541750-8	2004	Therefore, we hypothesized that the enzyme involved in mitoguazone response of the liver is the polyamine oxidase, which acts on acetylated polyamines as substrate.	Mitoguazone	55-66	polyamine oxidase	Rattus norvegicus	96-113
15078871-5	2004	TAF7-deficient cells had decreased capacity for polyamine uptake (20% of CHO cells), decreased AP-1 activation, as well as resistance to MGBG-induced apoptosis.	Mitoguazone	137-141	transcription initiation factor TFIID subunit 7	Cricetulus griseus	0-4
15078871-6	2004	Stable expression of TAF7 in TAF7-deficient cells restored transport activity (55% of CHO cells), AP-1 gene transactivation (100% of CHO cells), and sensitivity to MGBG-induced apoptosis.	Mitoguazone	164-168	transcription initiation factor TFIID subunit 7	Cricetulus griseus	21-25
15078871-6	2004	Stable expression of TAF7 in TAF7-deficient cells restored transport activity (55% of CHO cells), AP-1 gene transactivation (100% of CHO cells), and sensitivity to MGBG-induced apoptosis.	Mitoguazone	164-168	transcription initiation factor TFIID subunit 7	Cricetulus griseus	29-33
15078871-9	2004	Decreased TAF7 expression, by RNA interference, in androgen-independent human prostate cancer LN-CaP104-R1 cells resulted in lower polyamine transport activity (25% of control) and resistance to MGBG-induced growth arrest.	Mitoguazone	195-199	TATA-box binding protein associated factor 7	Homo sapiens	10-14
15078871-10	2004	Taken together, these results reveal a physiological function of TAF7 as a basal regulator for mammalian polyamine transport activity and MGBG-induced apoptosis.	Mitoguazone	138-142	TATA-box binding protein associated factor 7	Homo sapiens	65-69
11781274-2	2002	METHODS: Inhibition of JNK and p38 MAPK activation with CNI-1493, a guanylhydrazone, was tested in vitro.	Mitoguazone	68-83	mitogen-activated protein kinase 8	Homo sapiens	23-26
11781274-2	2002	METHODS: Inhibition of JNK and p38 MAPK activation with CNI-1493, a guanylhydrazone, was tested in vitro.	Mitoguazone	68-83	mitogen-activated protein kinase 14	Homo sapiens	31-34
10782045-6	2000	In mammary gland explants from midpregnant (10-14 days of pregnancy) mice, MGBG at 100 microM abolished the prolactin stimulation of iodide uptake and incorporation into milk proteins, whereas DFMO caused a concentration-dependent inhibition of the PRL response.	Mitoguazone	75-79	prolactin	Mus musculus	108-117
10944598-2	2000	SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG).	Mitoguazone	187-222	adenosylmethionine decarboxylase 1	Homo sapiens	112-117
10944598-2	2000	SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG).	Mitoguazone	224-228	adenosylmethionine decarboxylase 1	Homo sapiens	76-110
10944598-2	2000	SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG).	Mitoguazone	224-228	adenosylmethionine decarboxylase 1	Homo sapiens	112-117
10547152-1	1999	CNI-1493, a newly developed, water-soluble tetravalent guanylhydrazone, is a powerful inhibitor of tumor necrosis factor (TNF) and interleukin-1 (IL-1) synthesis.	Mitoguazone	55-70	tumor necrosis factor	Rattus norvegicus	122-125
10430362-8	1999	The increase in DNA synthesis caused by transforming growth factor-alpha, hepatocyte growth factor, or both was completely inhibited by alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone).	Mitoguazone	188-203	transforming growth factor alpha	Rattus norvegicus	40-72
10066828-6	1999	In addition, the tetravalent guanylhydrazone inhibitor of proinflammatory cytokine production, CNI-1493, can block the activation of p54 and p38 MAP kinases by IL-2 but has no effect on IL-2-driven proliferation of BA/F3 cells, activated primary T cells, or a cytotoxic T cell line.	Mitoguazone	29-44	interferon-induced protein with tetratricopeptide repeats 2	Mus musculus	133-136
10066828-6	1999	In addition, the tetravalent guanylhydrazone inhibitor of proinflammatory cytokine production, CNI-1493, can block the activation of p54 and p38 MAP kinases by IL-2 but has no effect on IL-2-driven proliferation of BA/F3 cells, activated primary T cells, or a cytotoxic T cell line.	Mitoguazone	29-44	mitogen-activated protein kinase 14	Mus musculus	141-144
10066828-6	1999	In addition, the tetravalent guanylhydrazone inhibitor of proinflammatory cytokine production, CNI-1493, can block the activation of p54 and p38 MAP kinases by IL-2 but has no effect on IL-2-driven proliferation of BA/F3 cells, activated primary T cells, or a cytotoxic T cell line.	Mitoguazone	29-44	interleukin 2	Mus musculus	160-164
10430362-8	1999	The increase in DNA synthesis caused by transforming growth factor-alpha, hepatocyte growth factor, or both was completely inhibited by alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone).	Mitoguazone	188-203	myotrophin	Rattus norvegicus	53-66
9933418-1	1999	A recently developed compound, a multivalent guanylhydrazone (CNI-1493) that inhibits TNF-alpha production by suppressing TNF-alpha translational efficiency, was administered in an experimental model of collagen type II-induced arthritis in DA rats.	Mitoguazone	45-60	tumor necrosis factor	Rattus norvegicus	86-95
9933418-1	1999	A recently developed compound, a multivalent guanylhydrazone (CNI-1493) that inhibits TNF-alpha production by suppressing TNF-alpha translational efficiency, was administered in an experimental model of collagen type II-induced arthritis in DA rats.	Mitoguazone	45-60	tumor necrosis factor	Rattus norvegicus	122-131
9361344-4	1997	Similar results were achieved by systemic administration of CNI-1493, a recently described tetravalent guanylhydrazone compound, which effectively inhibited endogenous brain TNF synthesis and conferred significant protection against the development of cerebral infarction (80% reduced infarct volume as compared with vehicle controls treated 1 h postischemia with 10 mg/kg).	Mitoguazone	103-118	tumor necrosis factor-like	Rattus norvegicus	174-177
9880821-9	1998	SAMDC inhibitor, methylglyoxal-bis-guanylhydrazone, induced growth arrest which was not reversed by exogenous putrescine, but only by high concentrations of spermidine.	Mitoguazone	17-50	adenosylmethionine decarboxylase 1	Homo sapiens	0-5
9677309-11	1998	Methylglyoxal-bis(guanylhydrazone) (MGBG), a potent inhibitor of human AdoMetDC, was a poor inhibitor of the T. cruzi enzyme.	Mitoguazone	0-34	adenosylmethionine decarboxylase 1	Homo sapiens	71-79
9677309-11	1998	Methylglyoxal-bis(guanylhydrazone) (MGBG), a potent inhibitor of human AdoMetDC, was a poor inhibitor of the T. cruzi enzyme.	Mitoguazone	36-40	adenosylmethionine decarboxylase 1	Homo sapiens	71-79
9677309-12	1998	This differential sensitivity to MGBG suggests that the two enzymes are sufficiently different to warrant the search for compounds that might interfere with the progression of Chagas" disease by selectively inhibiting T. cruzi AdoMetDC.	Mitoguazone	33-37	adenosylmethionine decarboxylase 1	Homo sapiens	227-235
9539777-0	1998	The tetravalent guanylhydrazone CNI-1493 blocks the toxic effects of interleukin-2 without diminishing antitumor efficacy.	Mitoguazone	16-31	interleukin 2	Rattus norvegicus	69-82
9539777-3	1998	CNI-1493, a tetravalent guanylhydrazone, is an inhibitor of macrophage activation including the synthesis of TNF and other cytokines.	Mitoguazone	24-39	tumor necrosis factor-like	Rattus norvegicus	109-112
9826717-4	1998	In the present studies, we found that fetuin is necessary for macrophages to respond to CNI-1493, a tetravalent guanylhydrazone inhibitor of p38 mitogen-activated protein kinase phosphorylation.	Mitoguazone	112-127	mitogen-activated protein kinase 14	Homo sapiens	141-144
9773808-0	1998	Mitoguazone induces apoptosis via a p53-independent mechanism.	Mitoguazone	0-11	tumor protein p53	Homo sapiens	36-39
9773808-8	1998	The present study demonstrated that mitoguazone induces apoptosis in all the different human cancer cell lines tested in a concentration- and time-dependent way, and triggers a p53-independent programmed cell death in the human breast cancer MCF7 cell line.	Mitoguazone	36-47	tumor protein p53	Homo sapiens	177-180
9527814-0	1998	QacA multidrug efflux pump from Staphylococcus aureus: comparative analysis of resistance to diamidines, biguanidines, and guanylhydrazones.	Mitoguazone	123-139	QacA	Staphylococcus aureus	0-4
9078276-13	1997	CGP 48664 and the parental compound methylglyoxal bis(guanylhydrazone), which is also a potent inhibitor of AdoMetDC, contain one or two AMG-like moieties; the importance of these residues in the inhibition of AdoMetDC is discussed.	Mitoguazone	36-69	S-adenosylmethionine decarboxylase 1	Mus musculus	108-116
9205949-6	1997	Blockade of p38 MAPK expression was achieved using antisense oligonucleotides to p38 MAPK and the guanylhydrazone compound CNI-1493, an inhibitor of p38 MAPK activation.	Mitoguazone	98-113	mitogen-activated protein kinase 14	Homo sapiens	12-15
9078276-13	1997	CGP 48664 and the parental compound methylglyoxal bis(guanylhydrazone), which is also a potent inhibitor of AdoMetDC, contain one or two AMG-like moieties; the importance of these residues in the inhibition of AdoMetDC is discussed.	Mitoguazone	36-69	S-adenosylmethionine decarboxylase 1	Mus musculus	210-218
8557774-7	1996	Treatment of these cells with methylglyoxal bis(guanylhydrazone) (MGBG), an AdoMetDC inhibitor which enters cell using polyamine transport system, shows no inhibition of cell growth.	Mitoguazone	66-70	adenosylmethionine decarboxylase 1	Homo sapiens	76-84
8930762-1	1996	A reversed-phase (C18) HPLC method with diode-array detection was developed for the separation and determination of methylglyoxal bis(amidinohydrazone) (mitoguazone) and seven closely related aliphatic analogs thereof, namely the bis(amidinohydrazones) of glyoxal, dimethylglyoxal, ethylmethylglyoxal, methylpropylglyoxal, butylmethylglyoxal, diethylglyoxal and dipropylglyoxal.	Mitoguazone	116-151	Bardet-Biedl syndrome 9	Homo sapiens	18-21
8930762-1	1996	A reversed-phase (C18) HPLC method with diode-array detection was developed for the separation and determination of methylglyoxal bis(amidinohydrazone) (mitoguazone) and seven closely related aliphatic analogs thereof, namely the bis(amidinohydrazones) of glyoxal, dimethylglyoxal, ethylmethylglyoxal, methylpropylglyoxal, butylmethylglyoxal, diethylglyoxal and dipropylglyoxal.	Mitoguazone	153-164	Bardet-Biedl syndrome 9	Homo sapiens	18-21
8877009-11	1996	These data demonstrate structure-activity relationships of a series of MGBG derivatives on cell growth, enzyme activities, and polyamine biosynthesis in a hormone-responsive breast cancer cell line and suggest potential application of SAMDC inhibitors as therapeutic agents.	Mitoguazone	71-75	adenosylmethionine decarboxylase 1	Homo sapiens	235-240
8143969-8	1994	On the other hand, methylglyoxal bis(guanylhydrazone) completely inhibited hepatocyte growth factor-induced DNA synthesis to nontreated control level.	Mitoguazone	19-53	hepatocyte growth factor	Homo sapiens	75-99
8205541-1	1994	Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis(guanylhydrazone) (MGBG), have been shown to have significant antitumor activity in several human solid tumor systems (U. Regenass et al., Cancer Res., 52:4712-4718, 1992).	Mitoguazone	105-139	adenosylmethionine decarboxylase 1	Homo sapiens	48-82
8205541-1	1994	Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis(guanylhydrazone) (MGBG), have been shown to have significant antitumor activity in several human solid tumor systems (U. Regenass et al., Cancer Res., 52:4712-4718, 1992).	Mitoguazone	105-139	adenosylmethionine decarboxylase 1	Homo sapiens	84-89
8205541-1	1994	Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis(guanylhydrazone) (MGBG), have been shown to have significant antitumor activity in several human solid tumor systems (U. Regenass et al., Cancer Res., 52:4712-4718, 1992).	Mitoguazone	141-145	adenosylmethionine decarboxylase 1	Homo sapiens	48-82
8205541-1	1994	Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis(guanylhydrazone) (MGBG), have been shown to have significant antitumor activity in several human solid tumor systems (U. Regenass et al., Cancer Res., 52:4712-4718, 1992).	Mitoguazone	141-145	adenosylmethionine decarboxylase 1	Homo sapiens	84-89
7575683-9	1995	In experiments with pure gamma-GT, the oligoamines putrescine, spermidine and spermine, and cystamine proved to be acceptor substrates for gamma-GT, all having similar efficiencies (Vmax/Km); methylglyoxal-bis-(guanyl-hydrazone) and paraquat were not accepted.	Mitoguazone	192-227	gamma-glutamyltransferase 1	Rattus norvegicus	139-147
7634128-11	1995	In vitro, treatment with DL-alpha-difluoromethylornithine (DFMO) or methylglyoxal bis-(guanylhydrazone) (MGBG) led to an increase in AdoMetDC.	Mitoguazone	68-103	S-adenosylmethionine decarboxylase 1	Mus musculus	133-141
7634128-11	1995	In vitro, treatment with DL-alpha-difluoromethylornithine (DFMO) or methylglyoxal bis-(guanylhydrazone) (MGBG) led to an increase in AdoMetDC.	Mitoguazone	105-109	S-adenosylmethionine decarboxylase 1	Mus musculus	133-141
7803479-6	1994	MGBG was shown to inhibit SAMDC II competitively like SAMDC I. Carbonyl and sulfhydryl group specific reagents modified SAMDC II, resulting in the loss of enzymatic activity.	Mitoguazone	0-4	S-adenosylmethionine decarboxylase	Glycine max	26-31
7803479-6	1994	MGBG was shown to inhibit SAMDC II competitively like SAMDC I. Carbonyl and sulfhydryl group specific reagents modified SAMDC II, resulting in the loss of enzymatic activity.	Mitoguazone	0-4	S-adenosylmethionine decarboxylase	Glycine max	54-59
7803479-6	1994	MGBG was shown to inhibit SAMDC II competitively like SAMDC I. Carbonyl and sulfhydryl group specific reagents modified SAMDC II, resulting in the loss of enzymatic activity.	Mitoguazone	0-4	S-adenosylmethionine decarboxylase	Glycine max	54-59
7930996-6	1994	Methylglyoxal bis-(guanylhydrazone), an inhibitor of polyamine biosynthesis, partially alleviated the effect of GH on lipogenesis; this was reversed by addition of spermidine.	Mitoguazone	0-34	somatotropin	Ovis aries	112-114
8143969-9	1994	The inhibitory effect of methylglyoxal bis(guanylhydrazone) on hepatocyte growth factor-induced DNA synthesis was reversed by exogenously added spermidine or spermine.	Mitoguazone	25-58	hepatocyte growth factor	Homo sapiens	63-87
8232285-4	1993	Methylglyoxal bis(guanylhydrazone) (MGBG) is an anti-leukemic agent with a strong inhibitory effect against AdoMetDC.	Mitoguazone	0-34	S-adenosylmethionine decarboxylase 1	Mus musculus	108-116
8232285-4	1993	Methylglyoxal bis(guanylhydrazone) (MGBG) is an anti-leukemic agent with a strong inhibitory effect against AdoMetDC.	Mitoguazone	36-40	S-adenosylmethionine decarboxylase 1	Mus musculus	108-116
8344293-1	1993	A variant cell line, termed SAM-1, which overproduced S-adenosylmethionine decarboxylase (AdoMetDC), was isolated by treatment of mouse FM3A cells with N-methyl-N"-nitro-N-nitrosoguanidine and subsequent incubation with ethylglyoxal bis(guanylhydrazone), an inhibitor of the enzyme.	Mitoguazone	237-252	S-adenosylmethionine decarboxylase 1	Mus musculus	54-88
8344293-1	1993	A variant cell line, termed SAM-1, which overproduced S-adenosylmethionine decarboxylase (AdoMetDC), was isolated by treatment of mouse FM3A cells with N-methyl-N"-nitro-N-nitrosoguanidine and subsequent incubation with ethylglyoxal bis(guanylhydrazone), an inhibitor of the enzyme.	Mitoguazone	237-252	S-adenosylmethionine decarboxylase 1	Mus musculus	90-98
1511437-1	1992	Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC).	Mitoguazone	0-34	adenosylmethionine decarboxylase 1	Homo sapiens	207-241
1480164-8	1992	The specificity of labeling of AdoMetDC by this procedure was confirmed by the prevention of 35S-decarboxylated S-adenosylmethionine (AdoMet) binding in the presence of specific AdoMetDC inhibitors [either methylglyoxal bis(guanylhydrazone (MGBG), a reversible inhibitor, or 5"-deoxy-5"-[(2-hydrazinoethyl)methylamino]adenosine (MHZEA), an irreversible inactivator].	Mitoguazone	206-239	adenosylmethionine decarboxylase 1	Homo sapiens	31-39
1480164-8	1992	The specificity of labeling of AdoMetDC by this procedure was confirmed by the prevention of 35S-decarboxylated S-adenosylmethionine (AdoMet) binding in the presence of specific AdoMetDC inhibitors [either methylglyoxal bis(guanylhydrazone (MGBG), a reversible inhibitor, or 5"-deoxy-5"-[(2-hydrazinoethyl)methylamino]adenosine (MHZEA), an irreversible inactivator].	Mitoguazone	241-245	adenosylmethionine decarboxylase 1	Homo sapiens	31-39
1480164-9	1992	As compared to human AdoMetDC, the trypanosomal enzyme showed weaker binding to a column of MGBG-Sepharose and also was significantly less sensitive to inhibition by MGBG and its congener ethylglyoxal bis(guanylhydrazone) (EGBG).	Mitoguazone	92-96	adenosylmethionine decarboxylase 1	Homo sapiens	21-29
1480164-9	1992	As compared to human AdoMetDC, the trypanosomal enzyme showed weaker binding to a column of MGBG-Sepharose and also was significantly less sensitive to inhibition by MGBG and its congener ethylglyoxal bis(guanylhydrazone) (EGBG).	Mitoguazone	166-170	adenosylmethionine decarboxylase 1	Homo sapiens	21-29
1511437-1	1992	Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC).	Mitoguazone	0-34	adenosylmethionine decarboxylase 1	Homo sapiens	243-248
1511437-1	1992	Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC).	Mitoguazone	36-40	adenosylmethionine decarboxylase 1	Homo sapiens	207-241
1511437-1	1992	Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC).	Mitoguazone	36-40	adenosylmethionine decarboxylase 1	Homo sapiens	243-248
1511437-2	1992	A series of four SAMDC inhibitors with structural features similar to MGBG have been found to have improved potency and specificity toward the target enzyme, SAMDC.	Mitoguazone	70-74	adenosylmethionine decarboxylase 1	Homo sapiens	17-22
1511437-2	1992	A series of four SAMDC inhibitors with structural features similar to MGBG have been found to have improved potency and specificity toward the target enzyme, SAMDC.	Mitoguazone	70-74	adenosylmethionine decarboxylase 1	Homo sapiens	158-163
1511437-3	1992	Relative to MGBG, the new derivatives were much more effective in inhibiting partially purified preparations of SAMDC (50% inhibitory concentration, 10 to 100 nM), much less effective at inhibiting diamine oxidase, and inactive toward ornithine decarboxylase.	Mitoguazone	12-16	adenosylmethionine decarboxylase 1	Homo sapiens	112-117
1507205-3	1992	In addition, AdoMet-DC activity could not be restored following extensive dialysis of the enzyme-inhibitor complex, and the enzyme was protected from irreversible inactivation by the known competitive inhibitor methylglyoxal bis(guanylhydrazone).	Mitoguazone	229-244	adenosylmethionine decarboxylase 1	Homo sapiens	13-22
1637820-1	1992	Human S-adenosylmethionine decarboxylase (AdoMetDC) was expressed in high yield in Escherichia coli using the pIN-III(lppP-5) expression vector and purified to apparent homogeneity using affinity chromatography on methylglyoxal bis(guanylhydrazone)-Sepharose.	Mitoguazone	214-248	adenosylmethionine decarboxylase 1	Homo sapiens	6-40
1637820-1	1992	Human S-adenosylmethionine decarboxylase (AdoMetDC) was expressed in high yield in Escherichia coli using the pIN-III(lppP-5) expression vector and purified to apparent homogeneity using affinity chromatography on methylglyoxal bis(guanylhydrazone)-Sepharose.	Mitoguazone	214-248	adenosylmethionine decarboxylase 1	Homo sapiens	42-50
2571411-0	1989	Non-p-glycoprotein-mediated multidrug resistance in detransformed rat cells selected for resistance to methylglyoxal bis(guanylhydrazone).	Mitoguazone	103-136	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	4-18
1618323-3	1992	In the studies reported here, it was found that inhibitors of polyamine biosynthesis, methylglyoxal-bis[quanylhydrazone] (MGBG) and difluoromethylornithine (DFMO), prevent mitogen-induced accumulation of mRNAs encoding major cytoskeletal components, beta-actin and alpha-tubulin, in mouse splenocytes.	Mitoguazone	122-126	actin, beta	Mus musculus	250-260
1764068-1	1991	S-Adenosylmethionine decarboxylase (EC 4.1.1.19) was purified to homogeneity from the cytosol of soybean (Glycine max) axes by ammonium sulfate fractionation, DEAE-Sepharose and methylglyoxalbis(guanylhydrazone)-Sepharose 6B chromatographies.	Mitoguazone	178-210	S-adenosylmethionine decarboxylase	Glycine max	0-34
34415722-6	2021	These guanylhydrazone-based inhibitor complexes showed for the first time an active site-directed binding mode to furin"s OFF-state conformation.	Mitoguazone	6-21	furin, paired basic amino acid cleaving enzyme	Homo sapiens	114-119
34415722-10	2021	We also tested the proprotein convertases PC5/6 and PC7 for inhibition by guanylhydrazones and found an up to 7-fold lower potency for PC7.	Mitoguazone	74-90	proprotein convertase subtilisin/kexin type 5	Homo sapiens	42-47
34415722-10	2021	We also tested the proprotein convertases PC5/6 and PC7 for inhibition by guanylhydrazones and found an up to 7-fold lower potency for PC7.	Mitoguazone	74-90	proprotein convertase subtilisin/kexin type 7	Homo sapiens	52-55
34415722-10	2021	We also tested the proprotein convertases PC5/6 and PC7 for inhibition by guanylhydrazones and found an up to 7-fold lower potency for PC7.	Mitoguazone	74-90	proprotein convertase subtilisin/kexin type 7	Homo sapiens	135-138
3143363-3	1988	By contrast, polyamine uptake was markedly increased in N-myc-transfected cells, as indicated by their enhanced sensitivity to the antiproliferative and enzyme regulatory effects of the polyamine analog, N1, N12-bis(ethyl)spermine (BESm), their intracellular accumulation of BESm and by their increased sensitivity to the growth inhibitory effects of methylglyoxalbis(guanylhydrazone)--another analog which utilizes the polyamine transport mechanism.	Mitoguazone	368-383	MYCN proto-oncogene, bHLH transcription factor	Rattus norvegicus	56-61
2759031-6	1989	However, the spermidine synthesis inhibitor methylglyoxal-(bis)-guanylhydrazone does inhibit alpha-casein accumulation in a concentration-dependent and spermidine-recoverable manner in cells stimulated by PRL and linoleic acid.	Mitoguazone	44-79	casein alpha s1	Mus musculus	93-105
2924752-3	1989	alpha-Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits squamous metaplasia caused by asbestos or vitamin A deficiency, whereas addition of methylglyoxal bis(guanylhydrazone) (MGBG), a structural analog of spermidine and inhibitor of S-adenosylmethionine decarboxylase, causes an enhancement of metaplasia under both circumstances.	Mitoguazone	191-225	ornithine decarboxylase 1	Homo sapiens	92-95
2924752-3	1989	alpha-Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits squamous metaplasia caused by asbestos or vitamin A deficiency, whereas addition of methylglyoxal bis(guanylhydrazone) (MGBG), a structural analog of spermidine and inhibitor of S-adenosylmethionine decarboxylase, causes an enhancement of metaplasia under both circumstances.	Mitoguazone	227-231	ornithine decarboxylase 1	Homo sapiens	92-95
2463788-2	1989	The activity of SAT was induced by stimulation with phytohemagglutinin (PHA), calcium ionophore A23187, sodium n-butyrate, or methylglyoxal bis(guanylhydrazone) (MGBG).	Mitoguazone	126-160	spermidine/spermine N1-acetyltransferase 1	Bos taurus	16-19
2463788-2	1989	The activity of SAT was induced by stimulation with phytohemagglutinin (PHA), calcium ionophore A23187, sodium n-butyrate, or methylglyoxal bis(guanylhydrazone) (MGBG).	Mitoguazone	162-166	spermidine/spermine N1-acetyltransferase 1	Bos taurus	16-19
2463788-3	1989	When the cells were treated with a combination of PHA with either MGBG or butyrate, the increase in SAT was synergistic.	Mitoguazone	66-70	spermidine/spermine N1-acetyltransferase 1	Bos taurus	100-103
2463788-5	1989	The elevation in SAT caused by PHA or A23187 was inhibited by the simultaneous addition of 25 microM H-7, a protein kinase C inhibitor; the induction of the enzyme activity by MGBG or butyrate was slightly enhanced in the presence of H-7.	Mitoguazone	176-180	spermidine/spermine N1-acetyltransferase 1	Bos taurus	17-20
2496768-1	1989	It was established that difluoromethylornithine (DFMO) and methylglyoxal-bis(guanylhydrazone) blocked the mitogenic response of hepatocytes to epidermal growth factor.	Mitoguazone	59-93	epidermal growth factor	Homo sapiens	143-166
3778524-0	1986	Ornithine decarboxylase and spermidine/spermine N1-acetyltransferase are induced in K562 cells by S-adenosylmethionine decarboxylase inhibitor methylglyoxal bis(guanylhydrazone) but not by analogous methylglyoxal bis(butylamidinohydrazone).	Mitoguazone	143-176	ornithine decarboxylase 1	Homo sapiens	0-23
3579940-3	1987	The induction of ODC activity by TPA was specifically blocked by methylglyoxal bis(butylamidinohydrazone) (MGBB), a competitive inhibitor of ODC and S-adenosylmethionine decarboxylase, but not by the analog methylglyoxal bis(guanylhydrazone) (MGBG).	Mitoguazone	207-241	ornithine decarboxylase, structural 1	Mus musculus	17-20
3579940-3	1987	The induction of ODC activity by TPA was specifically blocked by methylglyoxal bis(butylamidinohydrazone) (MGBB), a competitive inhibitor of ODC and S-adenosylmethionine decarboxylase, but not by the analog methylglyoxal bis(guanylhydrazone) (MGBG).	Mitoguazone	243-247	ornithine decarboxylase, structural 1	Mus musculus	17-20
3815342-5	1987	Two variant clones (G1 and G2) were isolated and characterized: they were 5-fold more resistant to methylglyoxal bis(guanylhydrazone); they had a stable phenotype; they showed decreased drug uptake; they had a reduced ability to grow in soft agar, low serum, and nude mice; there was no detectable change in the restriction pattern of integrated viral genes or in the expression of the E1a and E1b proteins.	Mitoguazone	117-132	NADH:ubiquinone oxidoreductase subunit C2	Mus musculus	20-29
3819806-1	1987	Based on encouraging results of two previous ifosfamide-VP-16 salvage combinations, methyl-gag was added to ifosfamide, methotrexate, and etoposide (VP-16).	Mitoguazone	84-94	host cell factor C1	Homo sapiens	56-61
3819806-1	1987	Based on encouraging results of two previous ifosfamide-VP-16 salvage combinations, methyl-gag was added to ifosfamide, methotrexate, and etoposide (VP-16).	Mitoguazone	84-94	host cell factor C1	Homo sapiens	149-154
3341033-8	1988	In contrast, methylglyoxal bis(guanylhydrazone) inhibited the induction of both ODC and heme oxygenase evoked by DEM.	Mitoguazone	13-47	ornithine decarboxylase 1	Rattus norvegicus	80-83
2848638-3	1988	It was therefore best to give the melarsoprol towards the end of the DFMO regimen, and as a guanylhydrazone (TBG) also blocks trypanothione (polyamine) biosynthesis, if TBG/DFMO are given together the treatment period can be reduced to 8 days.	Mitoguazone	92-107	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	Mus musculus	109-112
2848638-3	1988	It was therefore best to give the melarsoprol towards the end of the DFMO regimen, and as a guanylhydrazone (TBG) also blocks trypanothione (polyamine) biosynthesis, if TBG/DFMO are given together the treatment period can be reduced to 8 days.	Mitoguazone	92-107	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	Mus musculus	169-172
3827937-17	1987	MGBG also inhibited purified pigeon breast carnitine acetyltransferase (CAT; Ki = 1.6 mM).	Mitoguazone	0-4	carnitine O-acetyltransferase	Rattus norvegicus	43-70
3827937-17	1987	MGBG also inhibited purified pigeon breast carnitine acetyltransferase (CAT; Ki = 1.6 mM).	Mitoguazone	0-4	carnitine O-acetyltransferase	Rattus norvegicus	72-75
3827937-18	1987	While MGBG appeared to be competitive with l-carnitine for both CPT and CAT, MGBG also exhibits a number of effects which may be mediated through membrane interaction and which are not reversed by carnitine.	Mitoguazone	6-10	carnitine O-acetyltransferase	Rattus norvegicus	72-75
3778524-0	1986	Ornithine decarboxylase and spermidine/spermine N1-acetyltransferase are induced in K562 cells by S-adenosylmethionine decarboxylase inhibitor methylglyoxal bis(guanylhydrazone) but not by analogous methylglyoxal bis(butylamidinohydrazone).	Mitoguazone	143-176	adenosylmethionine decarboxylase 1	Homo sapiens	98-132
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	189-223	ornithine decarboxylase 1	Homo sapiens	18-41
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	189-223	ornithine decarboxylase 1	Homo sapiens	43-46
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	189-223	adenosylmethionine decarboxylase 1	Homo sapiens	133-167
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	189-223	adenosylmethionine decarboxylase 1	Homo sapiens	169-177
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	225-229	ornithine decarboxylase 1	Homo sapiens	18-41
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	225-229	ornithine decarboxylase 1	Homo sapiens	43-46
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	225-229	adenosylmethionine decarboxylase 1	Homo sapiens	133-167
3778524-1	1986	The activities of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) were increased by the addition of S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor methylglyoxal bis(guanylhydrazone) (MGBG) in cultured human erythroid leukemia K 562 cells.	Mitoguazone	225-229	adenosylmethionine decarboxylase 1	Homo sapiens	169-177
3778524-4	1986	The increases of both ODC and SAT activities produced by MGBG were blocked by treatment with cycloheximide, suggesting that the increase of enzyme activity resulted from the synthesis of new enzyme proteins.	Mitoguazone	57-61	ornithine decarboxylase 1	Homo sapiens	22-25
3778524-6	1986	On the other hand, methylglyoxal bis(butylamidinohydrazone) (MGBB), a derivative of MGBG inhibiting AdoMetDC effectively, did not induce ODC or SAT activities.	Mitoguazone	84-88	adenosylmethionine decarboxylase 1	Homo sapiens	100-108
3528175-0	1986	Selective increase of c-myc mRNA levels by methylglyoxal-bis (guanylhydrazone) and novobiocin in serum-stimulated fibroblasts.	Mitoguazone	43-77	myc proto-oncogene protein	Mesocricetus auratus	22-27
3528175-6	1986	We found that 100 microM MGBG induced an overaccumulation of c-myc RNA while H3 RNA was decreased, and the steady-state levels of all other RNAs were the same as in cells stimulated without the drug.	Mitoguazone	25-29	myc proto-oncogene protein	Mesocricetus auratus	61-66
3800910-5	1986	brucei AdoMet decarboxylase activity was apparently irreversibly inhibited in vitro by Berenil and reversibly by pentamidine and methylglyoxal bis(guanylhydrazone).	Mitoguazone	129-162	methionine adenosyltransferase 1A	Rattus norvegicus	7-13
3754136-11	1986	Methylglyoxal bis(guanylhydrazone), an inhibitor of S-adenosylmethionine decarboxylase, significantly inhibited the Co2+-mediated induction of both ODC and haem oxygenase.	Mitoguazone	0-33	ornithine decarboxylase 1	Rattus norvegicus	148-151
3931086-4	1985	At concentrations of 1 microM and above methylglyoxal bis(guanylhydrazone) (MGBG), which inhibits S-adenosylmethionine decarboxylase and hence the conversion of putrescine to spermidine and spermine, abolished the mitogenic action of prolactin.	Mitoguazone	40-74	prolactin	Homo sapiens	234-243
3455877-1	1986	Methylglyoxal bis(butylamidinohydrazone) (MGBB) inhibited S-adenosylmethionine decarboxylase (SAMDC) activity competitively with S-adenosylmethionine (SAM) showing the Ki value of 1.8 X 10(-5) M. MGBB showed less SAMDC-stabilizing effect in rat liver in vivo than did methylglyoxal bis-(guanylhydrazone) (MGBG).	Mitoguazone	268-303	adenosylmethionine decarboxylase 1	Homo sapiens	58-92
3455877-1	1986	Methylglyoxal bis(butylamidinohydrazone) (MGBB) inhibited S-adenosylmethionine decarboxylase (SAMDC) activity competitively with S-adenosylmethionine (SAM) showing the Ki value of 1.8 X 10(-5) M. MGBB showed less SAMDC-stabilizing effect in rat liver in vivo than did methylglyoxal bis-(guanylhydrazone) (MGBG).	Mitoguazone	268-303	adenosylmethionine decarboxylase 1	Homo sapiens	94-99
3455877-1	1986	Methylglyoxal bis(butylamidinohydrazone) (MGBB) inhibited S-adenosylmethionine decarboxylase (SAMDC) activity competitively with S-adenosylmethionine (SAM) showing the Ki value of 1.8 X 10(-5) M. MGBB showed less SAMDC-stabilizing effect in rat liver in vivo than did methylglyoxal bis-(guanylhydrazone) (MGBG).	Mitoguazone	305-309	adenosylmethionine decarboxylase 1	Homo sapiens	58-92
3455877-1	1986	Methylglyoxal bis(butylamidinohydrazone) (MGBB) inhibited S-adenosylmethionine decarboxylase (SAMDC) activity competitively with S-adenosylmethionine (SAM) showing the Ki value of 1.8 X 10(-5) M. MGBB showed less SAMDC-stabilizing effect in rat liver in vivo than did methylglyoxal bis-(guanylhydrazone) (MGBG).	Mitoguazone	305-309	adenosylmethionine decarboxylase 1	Homo sapiens	94-99
2872008-0	1986	Effects of phenylated compounds of methylglyoxal bis(guanylhydrazone) on diamine oxidase activity from rat small intestine.	Mitoguazone	35-69	amine oxidase, copper containing 1	Rattus norvegicus	73-88
2872008-1	1986	Two phenylated compounds of methylglyoxal bis(guanylhydrazone), potentially inhibitors of diamine oxidase activity, have been synthesized: phenylglyoxal bis(guanylhydrazone) and diphenylglyoxal bis(guanylhydrazone).	Mitoguazone	28-61	amine oxidase, copper containing 1	Rattus norvegicus	90-105
3931086-4	1985	At concentrations of 1 microM and above methylglyoxal bis(guanylhydrazone) (MGBG), which inhibits S-adenosylmethionine decarboxylase and hence the conversion of putrescine to spermidine and spermine, abolished the mitogenic action of prolactin.	Mitoguazone	76-80	prolactin	Homo sapiens	234-243
3878657-1	1985	The activity of coumarin 7-hydroxylase (coumarin 7-hydroxylation) was inhibited in B6 mouse liver after a single injection of methylglyoxal bis(guanylhydrazone (MGBG).	Mitoguazone	126-159	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	16-38
4052449-7	1985	These results indicate that methylglyoxal bis(guanylhydrazone) affects cellular polyamine levels not only by means of its inhibitory effect on S-adenosylmethionine decarboxylase and diamine oxidase but also by the induction of spermidine/spermine N1-acetyltransferase.	Mitoguazone	28-62	amine oxidase, copper containing 1	Rattus norvegicus	182-197
3878657-1	1985	The activity of coumarin 7-hydroxylase (coumarin 7-hydroxylation) was inhibited in B6 mouse liver after a single injection of methylglyoxal bis(guanylhydrazone (MGBG).	Mitoguazone	161-165	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	16-38
3878657-3	1985	The amount of cytochrome P-450 also was decreased in MGBG-treated livers with the same time-dependency as the inhibition of coumarin 7-hydroxylation.	Mitoguazone	53-57	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	14-30
3878657-4	1985	MGBG and its close derivative 1,1"-[methylethanediylidene)dinitrilo)bis(3-aminoguanidine) (MBAG) inhibited the activity in vitro of coumarin 7-hydroxylase, benzo(a)pyrene hydroxylase and 7-ethoxy 0-de-ethylase when microsomes were prepared from livers of untreated B6 mice.	Mitoguazone	0-4	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	132-154
6420041-4	1984	Since alpha-difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG) are irreversible and competitive inhibitors of ODC and SAMDC, respectively, they were tested as single agents and in combination on a transplantable rapidly growing and hormone-resistant G subline of the Dunning R-3327 rat prostatic adenocarcinoma.	Mitoguazone	82-86	ornithine decarboxylase 1	Rattus norvegicus	135-138
6426466-0	1984	Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation.	Mitoguazone	96-129	amine oxidase, copper-containing 1	Mus musculus	53-68
6426466-1	1984	Several congeners of methylglyoxal bis(guanylhydrazone) were tested for their ability to inhibit eukaryotic putrescine-activated S-adenosylmethionine decarboxylase (EC 4.1.1.50) and intestinal diamine oxidase (EC 1.4.3.6).	Mitoguazone	21-55	amine oxidase, copper-containing 1	Mus musculus	193-208
3982412-2	1985	In this study, we have shown by segregation analysis of intraspecific somatic cell hybrids that the hemizygous gene locus associated with resistance to methylglyoxalbisguanyl hydrazone (MBG) in CHO cells is linked to the hemizygous IDH2 locus on chromosome Z3.	Mitoguazone	152-184	isocitrate dehydrogenase [NADP], mitochondrial	Cricetulus griseus	232-236
6509066-0	1984	Stabilization of ornithine decarboxylase and N1-spermidine acetyltransferase in rat liver by methylglyoxal bis(guanylhydrazone).	Mitoguazone	93-126	ornithine decarboxylase 1	Rattus norvegicus	17-40
6509066-1	1984	The activities of ornithine decarboxylase and spermidine N1-acetyltransferase started to rise in normal rat liver 4 h after the intraperitoneal injection of methylglyoxal bis(guanylhydrazone) (MGBG; 80 mg/kg).	Mitoguazone	157-191	ornithine decarboxylase 1	Rattus norvegicus	18-41
6509066-1	1984	The activities of ornithine decarboxylase and spermidine N1-acetyltransferase started to rise in normal rat liver 4 h after the intraperitoneal injection of methylglyoxal bis(guanylhydrazone) (MGBG; 80 mg/kg).	Mitoguazone	193-197	ornithine decarboxylase 1	Rattus norvegicus	18-41
6509066-3	1984	Measurement of the apparent half-life of ornithine decarboxylase after MGBG treatment revealed a clear decrease in the decay rate of the enzyme in both normal and regenerating rat liver.	Mitoguazone	71-75	ornithine decarboxylase 1	Rattus norvegicus	41-64
6509066-6	1984	In the case of ornithine decarboxylase, studies with a specific antibody against mouse kidney ornithine decarboxylase showed that the rise in ornithine decarboxylase activity after MGBG application was not due to the appearance of an immunologically different isozyme.	Mitoguazone	181-185	ornithine decarboxylase, structural 1	Mus musculus	15-38
6509066-6	1984	In the case of ornithine decarboxylase, studies with a specific antibody against mouse kidney ornithine decarboxylase showed that the rise in ornithine decarboxylase activity after MGBG application was not due to the appearance of an immunologically different isozyme.	Mitoguazone	181-185	ornithine decarboxylase, structural 1	Mus musculus	94-117
6509066-6	1984	In the case of ornithine decarboxylase, studies with a specific antibody against mouse kidney ornithine decarboxylase showed that the rise in ornithine decarboxylase activity after MGBG application was not due to the appearance of an immunologically different isozyme.	Mitoguazone	181-185	ornithine decarboxylase, structural 1	Mus musculus	94-117
6743338-4	1984	In combination with inhibitors of polyamine biosynthesis, growth inhibition was greatly increased with methylglyoxal bis(guanylhydrazone), an inhibitor of AdoMet decarboxylase, but only slightly increased with alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase.	Mitoguazone	103-136	ornithine decarboxylase, structural 1	Mus musculus	257-280
6424664-3	1984	The frequently reported restoration of difluoromethylornithine-induced polyamine depletion on administration of methylglyoxal bis(guanylhydrazone) is in all likelihood attributable to a profound inhibition of intestinal diamine oxidase (EC 1.4.3.6), resulting in an enhanced entry of intestinal (bacterial) diamines into general circulation and finally into tumour cells.	Mitoguazone	130-145	amine oxidase, copper-containing 1	Mus musculus	220-235
6538500-0	1984	Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.	Mitoguazone	97-130	methionine adenosyltransferase 1A	Rattus norvegicus	149-172
6420041-4	1984	Since alpha-difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG) are irreversible and competitive inhibitors of ODC and SAMDC, respectively, they were tested as single agents and in combination on a transplantable rapidly growing and hormone-resistant G subline of the Dunning R-3327 rat prostatic adenocarcinoma.	Mitoguazone	82-86	adenosylmethionine decarboxylase 1	Rattus norvegicus	143-148
6318594-0	1983	Assay of mono ADP-ribosyltransferase activity by using guanylhydrazones.	Mitoguazone	55-71	ecto-ADP-ribosyltransferase 3	Oryctolagus cuniculus	9-36
6435895-0	1984	CNS toxicity and CSF pharmacokinetics of intraventricular DFMO and MGBG in beagle dogs.	Mitoguazone	67-71	colony stimulating factor 2	Canis lupus familiaris	17-20
6195664-2	1983	This is supported by the fact that (MGBG) methylglyoxal bis(guanylhydrazone), a drug that inhibits the conversion of putrescine to spermidine, abolishes the effects of PRL on casein and lipid biosynthesis; the inhibitory effects of MGBG are reversed by the addition of spermidine to the culture medium.	Mitoguazone	42-75	prolactin	Mus musculus	168-171
6195664-2	1983	This is supported by the fact that (MGBG) methylglyoxal bis(guanylhydrazone), a drug that inhibits the conversion of putrescine to spermidine, abolishes the effects of PRL on casein and lipid biosynthesis; the inhibitory effects of MGBG are reversed by the addition of spermidine to the culture medium.	Mitoguazone	36-40	prolactin	Mus musculus	168-171
6786360-2	1981	Putrescine and spermidine depletion produced by alpha-difluoromethylornithine, an irreversible inhibitor or ornithine decarboxylase (EC 4.1.1.17), resulted in a strikingly enhanced cellular uptake of methylglyoxal bis(guanylhydrazone) in cultured Ehrlich ascites carcinoma cells and human lymphocytic leukemia cells.	Mitoguazone	200-233	ornithine decarboxylase, structural 1	Mus musculus	108-131
6401860-2	1983	Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated with significant antitumor effect.	Mitoguazone	135-168	ornithine decarboxylase 1	Homo sapiens	21-44
6401860-2	1983	Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated with significant antitumor effect.	Mitoguazone	171-175	ornithine decarboxylase 1	Homo sapiens	21-44
6896674-1	1982	The ability of methylglyoxal-bis(guanylhydrazone) (MGBG) and 4,4"-diacetyldiphenylurea-bis(guanylhydrazone) to interact with the hypoglycemic agent, phenethylbiguanide (DBI), in affecting the bioenergetic functions of isolated rat liver mitochondria was studied.	Mitoguazone	15-49	diazepam binding inhibitor	Rattus norvegicus	169-172
6896674-2	1982	DBI was found to increase markedly the inhibitory effect of either 4,4"-diacetyldiphenylurea-bis(guanylhydrazone) or MGBG on respiration of isolated rat liver mitochondria.	Mitoguazone	117-121	diazepam binding inhibitor	Rattus norvegicus	0-3
6896674-4	1982	As with MGBG and 4,4"-diacetyldiphenylurea-bis(guanylhydrazone), the potassium cationophore, valinomycin, increased the sensitivity of mitochondrial respiration to DBI.	Mitoguazone	8-12	diazepam binding inhibitor	Rattus norvegicus	164-167
6896674-6	1982	This drug interaction was extended to the level of antiproliferative activity in which DBI was found to potentiate the growth-inhibitory effects of MGBG on murine L1210 leukemia in vivo.	Mitoguazone	148-152	diazepam binding inhibitor	Mus musculus	87-90
7214342-5	1981	[14C]MGBG underwent no in vivo metabolism; it disappeared from the plasma with an average terminal t 1/2 of 4.1 hr.	Mitoguazone	5-9	interleukin 1 receptor like 1	Homo sapiens	99-111
7388796-8	1980	injection of MGBG (50 mg/kg), S-adenosylmethionine decarboxylase activity increased markedly, especially in the crypt region (approximately 50-fold), while ornithine decarboxylase activity also increased but to a lesser extent.	Mitoguazone	13-17	ornithine decarboxylase 1	Rattus norvegicus	156-179
14392887-0	1955	[The effects of hydrazine and guanylhydrazone derivatives on the activity of monoamine oxidase, diamine oxidase, DOPA decarboxylase and histidine decarboxylase].	Mitoguazone	30-45	amine oxidase copper containing 1	Homo sapiens	96-111
884669-2	1977	When excess putrescine accumulation in the presence of methylglyoxal bis(guanylhydrazone) was inhibited with alpha-methylornithine, a competitive inhibitor of ornithine decarboxylase, the inhibition of DNA replication was accentuated, with still no effect on protein or RNA synthesis.	Mitoguazone	55-88	ornithine decarboxylase 1	Homo sapiens	159-182
4205354-7	1973	Injection of methylglyoxal bis(guanylhydrazone) into the rat also markedly decreased the activity of diamine oxidase (EC 1.4.3.6) in thymus.	Mitoguazone	13-47	amine oxidase, copper containing 1	Rattus norvegicus	101-116
4205354-13	1973	In the diamine oxidase reaction, with putrescine as the substrate, methylglyoxal bis(guanylhydrazone) was a non-competitive inhibitor for putrescine.	Mitoguazone	67-100	amine oxidase, copper containing 1	Rattus norvegicus	7-22
14392887-0	1955	[The effects of hydrazine and guanylhydrazone derivatives on the activity of monoamine oxidase, diamine oxidase, DOPA decarboxylase and histidine decarboxylase].	Mitoguazone	30-45	dopa decarboxylase	Homo sapiens	113-131
33310703-6	2021	Interestingly, ATP13A3 complemented the putrescine transport deficiency and MGBG resistance of CHO-MG cells, whereas its knockdown in wild-type cells induced a CHO-MG phenotype, demonstrating a decrease in putrescine uptake and MGBG sensitivity.	Mitoguazone	76-80	probable cation-transporting ATPase 13A3	Cricetulus griseus	15-22
33310703-6	2021	Interestingly, ATP13A3 complemented the putrescine transport deficiency and MGBG resistance of CHO-MG cells, whereas its knockdown in wild-type cells induced a CHO-MG phenotype, demonstrating a decrease in putrescine uptake and MGBG sensitivity.	Mitoguazone	228-232	probable cation-transporting ATPase 13A3	Cricetulus griseus	15-22
33310703-7	2021	Taken together, our findings identify ATP13A3 as a major component of the mammalian PTS that confers sensitivity to MGBG and that has been previously genetically linked with pulmonary arterial hypertension.	Mitoguazone	116-120	ATPase 13A3	Homo sapiens	38-45
28462488-8	2017	MGBG treatment significantly diminished DRG histopathology and reduced the number of CD68+ and CD163+ macrophages in DRG tissue.	Mitoguazone	0-4	CD68 molecule	Macaca mulatta	85-89
29538412-0	2018	Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes.	Mitoguazone	0-33	secreted phosphoprotein 1	Homo sapiens	43-54
29538412-6	2018	We demonstrate that MGBG is a potent inhibitor of secreted OPN (sOPN) in cultured monocytes with 50% inhibition achieved at 0.1 muM of the drug.	Mitoguazone	20-24	secreted phosphoprotein 1	Homo sapiens	59-62
29538412-9	2018	MGBG inhibited both activities at similar doses to those regulating OPN expression.	Mitoguazone	0-4	secreted phosphoprotein 1	Homo sapiens	68-71
29538412-11	2018	The inhibition of differentiation and anti-OPN effects of MGBG were specific for monocytes in that differentiated macrophages were nearly resistant to MGBG activities.	Mitoguazone	58-62	secreted phosphoprotein 1	Homo sapiens	43-46
31020307-5	2019	The results are consistent and point to a significant contribution of the guanylhydrazone residue to the complexation process for AG1 and AG2 with beta-cyclodextrin.	Mitoguazone	74-89	thioredoxin domain containing 12	Homo sapiens	130-133
31020307-5	2019	The results are consistent and point to a significant contribution of the guanylhydrazone residue to the complexation process for AG1 and AG2 with beta-cyclodextrin.	Mitoguazone	74-89	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	138-141
26558640-0	2016	Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase.	Mitoguazone	37-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-117
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	CD163 molecule	Homo sapiens	47-52
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	CD68 molecule	Homo sapiens	66-70
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	mannose receptor C-type 1	Homo sapiens	84-89
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	S100 calcium binding protein A9	Homo sapiens	107-113
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	CD163 molecule	Homo sapiens	187-192
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	CD68 molecule	Homo sapiens	206-210
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	S100 calcium binding protein A9	Homo sapiens	224-230
28141779-8	2017	RESULTS: MGBG treatment resulted in 2.19-fold (CD163), 1.86-fold (CD68), 2.31-fold (CD206), and 2.12-fold (MAC387) decreases in macrophages in carotid arteries and significant 2.07-fold (CD163), 1.61-fold (CD68), 1.95-fold (MAC387), and 1.62-fold (CD206) decreases in macrophages in cardiac tissues.	Mitoguazone	9-13	mannose receptor C-type 1	Homo sapiens	248-253
26558640-4	2016	The most effective AChE inhibitor discovered was the guanylhydrazone derived from 2,4-dinitrobenzaldehyde and was compared with tacrine, displaying similar activity to this reference material.	Mitoguazone	53-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	19-23
26046259-8	2015	Methyl-G increased the intracellular concentration of a known Pgp substrate, Rhodamine 123 in SF-295 cells.	Mitoguazone	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	62-65
26725082-2	2016	The guanylhydrazone CNI-1493, a potent inhibitor of the deoxyhypusine synthase (DHS), prevents the activation of the cellular factor eIF-5A and thereby suppresses HIV replication and a number of other diseases.	Mitoguazone	4-19	deoxyhypusine synthase	Homo sapiens	56-78
26725082-2	2016	The guanylhydrazone CNI-1493, a potent inhibitor of the deoxyhypusine synthase (DHS), prevents the activation of the cellular factor eIF-5A and thereby suppresses HIV replication and a number of other diseases.	Mitoguazone	4-19	deoxyhypusine synthase	Homo sapiens	80-83
26725082-2	2016	The guanylhydrazone CNI-1493, a potent inhibitor of the deoxyhypusine synthase (DHS), prevents the activation of the cellular factor eIF-5A and thereby suppresses HIV replication and a number of other diseases.	Mitoguazone	4-19	eukaryotic translation initiation factor 5A	Homo sapiens	133-139
26867487-12	2016	On the basis of computational docking experiments using both human and cytochrome P450 from Candida it was concluded that the most active guanylhydrazones had minimal structural prerequisites to interact with the cytochrome P450 14alpha-demethylase (CYP51).	Mitoguazone	138-154	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	213-248
26867487-12	2016	On the basis of computational docking experiments using both human and cytochrome P450 from Candida it was concluded that the most active guanylhydrazones had minimal structural prerequisites to interact with the cytochrome P450 14alpha-demethylase (CYP51).	Mitoguazone	138-154	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	250-255
24877669-2	2014	Salt stress resulted in the deterioration of plant growth and photosynthesis, and treatment of plantlets with methylglyoxal-bis(guanylhydrazone) (MGBG), a S-adenosylmethionine decarboxylase (SAMDC) inhibitor, enhanced the salt stress effect.	Mitoguazone	110-144	S-adenosylmethionine decarboxylase proenzyme	Vitis vinifera	155-189
25046760-5	2014	Methylglyoxal-bis(guanylhydrazone) (MGBG), an inhibitor of SAMDC resulting in the inability of activated cells to synthesize Spd and Spm, exacerbates the negative effects induced by drought.	Mitoguazone	0-34	adenosylmethionine decarboxylase 1	Homo sapiens	59-64
25046760-5	2014	Methylglyoxal-bis(guanylhydrazone) (MGBG), an inhibitor of SAMDC resulting in the inability of activated cells to synthesize Spd and Spm, exacerbates the negative effects induced by drought.	Mitoguazone	36-40	adenosylmethionine decarboxylase 1	Homo sapiens	59-64
24877669-2	2014	Salt stress resulted in the deterioration of plant growth and photosynthesis, and treatment of plantlets with methylglyoxal-bis(guanylhydrazone) (MGBG), a S-adenosylmethionine decarboxylase (SAMDC) inhibitor, enhanced the salt stress effect.	Mitoguazone	110-144	S-adenosylmethionine decarboxylase proenzyme	Vitis vinifera	191-196
24877669-2	2014	Salt stress resulted in the deterioration of plant growth and photosynthesis, and treatment of plantlets with methylglyoxal-bis(guanylhydrazone) (MGBG), a S-adenosylmethionine decarboxylase (SAMDC) inhibitor, enhanced the salt stress effect.	Mitoguazone	146-150	S-adenosylmethionine decarboxylase proenzyme	Vitis vinifera	155-189
24877669-6	2014	MGBG alone or in combination with salt stress increased monodehydroascorbate reductase (MDHAR), SOD and POX activities and surprisingly no accumulation of DHA was noticed following treatment with MGBG.	Mitoguazone	0-4	monodehydroascorbate reductase	Vitis vinifera	56-86
24877669-6	2014	MGBG alone or in combination with salt stress increased monodehydroascorbate reductase (MDHAR), SOD and POX activities and surprisingly no accumulation of DHA was noticed following treatment with MGBG.	Mitoguazone	0-4	monodehydroascorbate reductase	Vitis vinifera	88-93