PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2519725-0	1989	2-ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine.	2-Naphthylamine	103-118	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	61-77
2737182-5	1989	Induction of MPCE in the bone marrow by four other compounds--benzo(a)pyrene, 2-naphthylamine, mitomycin C, and vincristine--was also increased by pretreatment with erythropoietin.	2-Naphthylamine	78-93	erythropoietin	Mus musculus	165-179
2495173-6	1989	Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole.	2-Naphthylamine	69-84	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	9-12
748018-2	1978	The beta-naphthylamide of Phe-Pro-Ala, modeled after the NH2-terminal tripeptide sequence of the phenylalanyl monomer of bovine growth hormone, was cleaved by the peptidase into the tripeptide and B-naphthylamine and served as a substrate for assay of the eznyme.	2-Naphthylamine	197-212	gonadotropin releasing hormone receptor	Rattus norvegicus	128-142
3706731-3	1986	The linear dynamic range for the aminopeptidase technique has been increased by achieving a reduced lower limit of detection of the fluorescent tag, beta-naphthylamine.	2-Naphthylamine	149-167	aminopeptidase	Agrobacterium tumefaciens	33-47
3919738-3	1985	Glucuronidation by Triton X-100 activated microsomes of the N-hydroxy derivative of 2-AN was approximately 1.5 and 1.8 times faster than the corresponding derivatives of 2-aminofluorene (2-AF) and 4-aminobiphenyl (4-ABP) respectively.	2-Naphthylamine	84-88	glutamate receptor interacting protein 2	Rattus norvegicus	216-219
3919738-4	1985	However, glucuronidation of the N-hydroxy-N-acetyl derivative of 2-AN was 40 and 17 times faster than the corresponding derivatives of 2-AF and 4-ABP respectively.	2-Naphthylamine	65-69	glutamate receptor interacting protein 2	Rattus norvegicus	146-149
7272282-3	1981	It was shown that the enzyme activities resulting in hydrolysis of the tyrosine residue of ([3,5-3H2]Tyr)Met-enkephalin and formation of beta-naphthylamine from Tyr-beta-naphthylamide copurified.	2-Naphthylamine	137-155	proenkephalin	Rattus norvegicus	109-119
3297038-2	1987	Our results indicate that, not only enteropeptidase, but also the concerted action of the aminopeptidases of the rat small intestine, can rapidly release 2-naphthylamine from the substrate.	2-Naphthylamine	154-169	transmembrane serine protease 15	Rattus norvegicus	36-51
3800318-6	1986	It is concluded that the metabolic activation of 2-naphthylamine proceeds via N-hydroxylation which is preferentially catalysed by the 3-methylcholanthrene inducible forms of cytochrome P-450, whereas ring-hydroxylation appears to be a deactivation pathway.	2-Naphthylamine	49-64	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	175-191
30387604-10	2018	Wide-SIM/MS2 detected multiple DNA adducts of 2-NA, 2-MA, and, 2,6-DMA, when calf thymus DNA was modified with reactive intermediates of these carcinogens.	2-Naphthylamine	46-50	MS2	Homo sapiens	9-12
32275370-15	2020	In the BNA+EA group, the DRG level of HDAC1 was decreased compared with the MT group and the sham BNA group (P<0.01, P<0.05), while the level of MOR was increased (P<0.01).	2-Naphthylamine	7-10	histone deacetylase 1	Homo sapiens	38-43
32275370-15	2020	In the BNA+EA group, the DRG level of HDAC1 was decreased compared with the MT group and the sham BNA group (P<0.01, P<0.05), while the level of MOR was increased (P<0.01).	2-Naphthylamine	7-10	opioid receptor mu 1	Homo sapiens	145-148
32275370-15	2020	In the BNA+EA group, the DRG level of HDAC1 was decreased compared with the MT group and the sham BNA group (P<0.01, P<0.05), while the level of MOR was increased (P<0.01).	2-Naphthylamine	98-101	histone deacetylase 1	Homo sapiens	38-43
32118871-2	2020	Despite the fact that 2-NA is not produced on an industrial scale, it is still used in small quantities as a model bladder carcinogen in laboratories, and also for sewage control, water analysis and oxytocinase assays.	2-Naphthylamine	22-26	leucyl and cystinyl aminopeptidase	Homo sapiens	199-210
28221392-1	2017	A 4,5-quinolimide derivative, BNA, bearing the amide-DPA receptor, was synthesized as a turn-on fluorescent sensor for Cd2+.	2-Naphthylamine	30-33	CD2 molecule	Homo sapiens	119-122
28221392-2	2017	Under physiological conditions, BNA could distinguish Cd2+ from Zn2+, showing turn-on fluorescence behaviour and an increased fluorescence lifetime.	2-Naphthylamine	32-35	CD2 molecule	Homo sapiens	54-57
28221392-4	2017	Furthermore, BNA was utilized for fluorescence imaging of Cd2+ in live cells.	2-Naphthylamine	13-16	CD2 molecule	Homo sapiens	58-61
28066224-8	2016	Results: BNA intraclass correlation values of repeatability ranged between 0.51 and 0.82 for the known ERP components N100, P200, and P300.	2-Naphthylamine	9-12	AT-rich interaction domain 2	Homo sapiens	124-128
28066224-8	2016	Results: BNA intraclass correlation values of repeatability ranged between 0.51 and 0.82 for the known ERP components N100, P200, and P300.	2-Naphthylamine	9-12	E1A binding protein p300	Homo sapiens	134-138
25224404-7	2015	Whereas 2-naphthylamine significantly activated the AhR and induced CYP1A1 expression, its N-acetylated metabolite was less efficient.	2-Naphthylamine	8-23	aryl hydrocarbon receptor	Homo sapiens	52-55
25224404-7	2015	Whereas 2-naphthylamine significantly activated the AhR and induced CYP1A1 expression, its N-acetylated metabolite was less efficient.	2-Naphthylamine	8-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	68-74
22350089-10	2012	Genetic and physical map data infer that this loss-of-function allele has replaced a functional Bna.CCR1 locus on chromosome C8 in GH06 by homoeologous non-reciprocal translocation.	2-Naphthylamine	96-99	cinnamoyl-CoA reductase 1	Brassica rapa	100-104
22360938-3	2012	SULT1 ST9 appeared to be mostly involved in the metabolism and detoxification of xenobiotics such as beta-naphthol, beta-naphthylamine, caffeic acid and gallic acid.	2-Naphthylamine	116-134	sulfotransferase family 1, cytosolic sulfotransferase 9	Danio rerio	0-9
22360938-5	2012	SULT3 ST5 showed weaker, but significant, activities toward endogenous compounds such as DHEA and corticosterone, as well as xenobiotics including mestranol, beta-naphthylamine, beta-naphthol, and butylated hydroxyl anisole (BHA).	2-Naphthylamine	158-176	sulfotransferase family 3, cytosolic sulfotransferase 3	Danio rerio	0-9
26071533-10	2015	Therefore, in addition to its classical function in trichome development, our study reveals a novel role for Bna.TTG2 genes in salt stress responses.	2-Naphthylamine	109-112	WRKY family transcription factor family protein	Arabidopsis thaliana	113-117
22758906-5	2012	(2) The single-electron reduction potential of CAF(+) is much more negative than that of BNA(+) [E(red) = -1.419 V], which means that CAF(+) is not a good electron acceptor.	2-Naphthylamine	89-92	lysine acetyltransferase 2B	Homo sapiens	134-140
23344002-0	2012	Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice.	2-Naphthylamine	31-34	proprotein convertase subtilisin/kexin type 9	Mus musculus	78-83
17674211-5	2007	To explain the metabolic dephenylation process, it has been suggested that PBNA is metabolized by cytochrome P-450 (CYP) enzymes to the phenolic derivative 4"-hydroxy-N-phenyl-2-naphthylamine, followed by its further oxidation to the quinone imine, which subsequently hydrolyses to form the dephenylation product 2-naphthylamine.	2-Naphthylamine	176-191	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-114
18989657-7	2008	Next, we studied co-exposures of 2-NA and B[a]P. Similar as for 4-ABP also 2-NA enhanced B[a]P-mediated induction of CYP1A1.	2-Naphthylamine	33-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
18989657-7	2008	Next, we studied co-exposures of 2-NA and B[a]P. Similar as for 4-ABP also 2-NA enhanced B[a]P-mediated induction of CYP1A1.	2-Naphthylamine	75-79	amine oxidase copper containing 1	Homo sapiens	66-69
18989657-7	2008	Next, we studied co-exposures of 2-NA and B[a]P. Similar as for 4-ABP also 2-NA enhanced B[a]P-mediated induction of CYP1A1.	2-Naphthylamine	75-79	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-123
21800401-0	2011	Spectroscopic investigation of the interaction of the toxicant, 2-naphthylamine, with bovine serum albumin.	2-Naphthylamine	64-79	albumin	Homo sapiens	93-106
21800401-1	2011	The mechanism of interaction between bovine serum albumin (BSA) and 2-naphthylamine (2-NA) in aqueous solution was investigated by fluorescence spectroscopy, circular dichroism (CD) spectra, and UV-vis spectroscopy.	2-Naphthylamine	68-83	albumin	Homo sapiens	44-57
21800401-1	2011	The mechanism of interaction between bovine serum albumin (BSA) and 2-naphthylamine (2-NA) in aqueous solution was investigated by fluorescence spectroscopy, circular dichroism (CD) spectra, and UV-vis spectroscopy.	2-Naphthylamine	85-89	albumin	Homo sapiens	44-57
21777516-3	2011	The assay for enteropeptidase has utilized GD(4)K-conjugated 2-naphthylamine (GD(4)K-NA) as a fluorogenic probe over the last 30 years.	2-Naphthylamine	61-76	transmembrane serine protease 15	Homo sapiens	14-29
19248797-3	2009	Arylamine N-acetyltransferases (NAT) are conjugating XMEs that play a key role in the biotransformation of aromatic amine pollutants such as the tobacco-smoke carcinogens 4-aminobiphenyl (4-ABP) and beta-naphthylamine (beta-NA).	2-Naphthylamine	199-217	auxin-binding protein T92	Nicotiana tabacum	190-193
19248797-3	2009	Arylamine N-acetyltransferases (NAT) are conjugating XMEs that play a key role in the biotransformation of aromatic amine pollutants such as the tobacco-smoke carcinogens 4-aminobiphenyl (4-ABP) and beta-naphthylamine (beta-NA).	2-Naphthylamine	219-226	auxin-binding protein T92	Nicotiana tabacum	190-193
18713828-1	2008	Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine.	2-Naphthylamine	108-123	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	0-19
18713828-1	2008	Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine.	2-Naphthylamine	108-123	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	21-27
17674211-5	2007	To explain the metabolic dephenylation process, it has been suggested that PBNA is metabolized by cytochrome P-450 (CYP) enzymes to the phenolic derivative 4"-hydroxy-N-phenyl-2-naphthylamine, followed by its further oxidation to the quinone imine, which subsequently hydrolyses to form the dephenylation product 2-naphthylamine.	2-Naphthylamine	176-191	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	116-119
14528034-4	2003	The activities of prolyl endopeptidase, pyroglutamyl peptidase I, puromycin sensitive aminopeptidase, and aminopeptidase N were assayed using beta-naphthylamine aminoacidic derivatives as substrates.	2-Naphthylamine	142-160	prolyl endopeptidase	Rattus norvegicus	18-38
16002239-7	2005	Ana can efficiently hydrolyze a series of cephalosporin analogous amides, including amides with an aninine, p-nitro-aninine, and beta-naphthylamine moiety, while cephalosporin could not serve as its substrate.	2-Naphthylamine	129-147	BTG anti-proliferation factor 3	Homo sapiens	0-3
15057901-11	2004	UGT1A4 P24T and L48V exhibited reduced glucuronidation activities: beta-naphthylamine 30% and 50%, and dihydrotestosterone 50% and 0%, respectively.	2-Naphthylamine	67-85	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	0-6
14528034-4	2003	The activities of prolyl endopeptidase, pyroglutamyl peptidase I, puromycin sensitive aminopeptidase, and aminopeptidase N were assayed using beta-naphthylamine aminoacidic derivatives as substrates.	2-Naphthylamine	142-160	alanyl aminopeptidase, membrane	Rattus norvegicus	106-122
12351147-6	2002	In this work, we have re-examined the feasibility of three proposed p450 oxidation mechanisms by comparing the experimental oxidation yields and rates of 1-naphthylamine (1-NA), 2-naphthylamine (2-NA) and 2-aminofluorene (2-AF).	2-Naphthylamine	178-193	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
12351147-6	2002	In this work, we have re-examined the feasibility of three proposed p450 oxidation mechanisms by comparing the experimental oxidation yields and rates of 1-naphthylamine (1-NA), 2-naphthylamine (2-NA) and 2-aminofluorene (2-AF).	2-Naphthylamine	195-199	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
11233991-0	2001	2-Naphthylamine, a compound found in cigarette smoke, decreases both monoamine oxidase A and B catalytic activity.	2-Naphthylamine	0-15	monoamine oxidase A	Mus musculus	69-88
11233991-6	2001	The results of this study show that 2-naphthylamine has the ability to inhibit mouse brain MAO A and B in vitro by mixed type inhibition (competitive and non-competitive).	2-Naphthylamine	36-51	monoamine oxidase A	Mus musculus	91-96
11233991-8	2001	The inhibitory effect of 2-naphthylamine on both MAO A and B catalytic activity, supports the hypothesis that smoking decreases MAO activity in vivo, instead that smokers with lower MAO activity are more prone to become a smoker.	2-Naphthylamine	25-40	monoamine oxidase A	Mus musculus	49-54
1687013-1	1991	Thermostable phenol sulfotransferase catalyzes the N-sulfation of 2-naphthylamine.	2-Naphthylamine	66-81	sulfotransferase family 1A member 2	Homo sapiens	0-36
9017438-0	1996	Increase in CD57 + CD16-lymphocytes in workers exposed to benzidine and beta-naphthylamine: assessment of natural killer cell subpopulations.	2-Naphthylamine	72-90	beta-1,3-glucuronyltransferase 1	Homo sapiens	12-16
9017438-0	1996	Increase in CD57 + CD16-lymphocytes in workers exposed to benzidine and beta-naphthylamine: assessment of natural killer cell subpopulations.	2-Naphthylamine	72-90	Fc gamma receptor IIIa	Homo sapiens	19-23
9017438-1	1996	Previously, we found a decrease in CD4 + CD45RA + T lymphocytes in workers exposed to the aromatic amines (AAs) [benzidine (BZ) and beta naphthylamine (BNA)].	2-Naphthylamine	132-150	CD4 molecule	Homo sapiens	35-38
9017438-1	1996	Previously, we found a decrease in CD4 + CD45RA + T lymphocytes in workers exposed to the aromatic amines (AAs) [benzidine (BZ) and beta naphthylamine (BNA)].	2-Naphthylamine	152-155	CD4 molecule	Homo sapiens	35-38
7618953-0	1995	Selective decrease of the suppressor-inducer (CD4+CD45RA+) T lymphocytes in workers exposed to benzidine and beta-naphthylamine.	2-Naphthylamine	109-127	CD4 molecule	Homo sapiens	46-49
7618953-1	1995	Previously, we reported a decrease of CD4+ T lymphocytes in workers exposed to benzidine and beta-naphthylamine, which are aromatic amines.	2-Naphthylamine	93-111	CD4 molecule	Homo sapiens	38-41
7628292-5	1995	Carcinogenic primary amines (beta-naphthylamine, benzidine, and 4-aminobiphenyl) also reacted with the expressed UGT1.4 protein at rates approximately 10-fold higher than the rates for quaternary ammonium glucuronide formation.	2-Naphthylamine	29-47	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	113-119
8200119-3	1994	Sample blanks values (0.76 +/- 1.28 g/L) demonstrated that the high Lp(a) levels obtained in the BNA assay are caused by nonspecific precipitation.	2-Naphthylamine	97-100	lipoprotein(a)	Homo sapiens	68-73
8291057-11	1994	The NAT2-dependent expression of N-acetyltransferase activity was evident toward p-aminobenzoic acid, 4-aminophenol, 2-aminofluorene, 4-aminobiphenyl, beta-naphthylamine, and 3,2"-dimethyl-4-amino-biphenyl in liver, kidney, colon, lung, and urinary bladder cytosols.	2-Naphthylamine	151-169	arylamine N-acetyltransferase 2	Mesocricetus auratus	4-8
8102843-0	1993	Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine.	2-Naphthylamine	75-93	CD4 molecule	Homo sapiens	12-15
8247812-2	1993	The binding of complementary sequences to bNA"s (for instance when N = dT, x = 0; y = 10 or x = y = 10 and the complement is dA10) yields transition temperatures (Tm"s) equal to or greater than those of the corresponding linear complexes of similar base composition.	2-Naphthylamine	42-45	antennal protein 10	Drosophila melanogaster	125-129
1687013-7	1991	For example, average temperatures that produced 50% inactivation of TL PST, TS PST, and AANST activities, measured with both 0.05 and 1.0 mM 2-NA as substrate, were 35.0, 40.5, 40.3 and 40.5 degrees C, respectively.	2-Naphthylamine	141-145	sulfotransferase family 1A member 3	Homo sapiens	68-74
1687013-8	1991	IC50 values for the inhibition by DCNP of TL PST, TS PST, and AANST, measured with 0.05 and 1.0 mM 2-NA as substrate, were 110, 1.8, 1.3, and 4.0 microM, respectively.	2-Naphthylamine	99-103	sulfotransferase family 1A member 3	Homo sapiens	42-48
35353990-10	2022	Incubation with the NAT1 inhibitor partially reduced the N-acetylation of beta-naphthylamine and the O-acetylation of N-hydroxy-4-aminobiphenyl consistent with catalysis by both NAT1 and NAT2.	2-Naphthylamine	74-92	N-acetyltransferase 1	Homo sapiens	20-24
35353990-10	2022	Incubation with the NAT1 inhibitor partially reduced the N-acetylation of beta-naphthylamine and the O-acetylation of N-hydroxy-4-aminobiphenyl consistent with catalysis by both NAT1 and NAT2.	2-Naphthylamine	74-92	N-acetyltransferase 1	Homo sapiens	178-182
35353990-10	2022	Incubation with the NAT1 inhibitor partially reduced the N-acetylation of beta-naphthylamine and the O-acetylation of N-hydroxy-4-aminobiphenyl consistent with catalysis by both NAT1 and NAT2.	2-Naphthylamine	74-92	N-acetyltransferase 2	Homo sapiens	187-191
35261232-3	2022	Here, we found that the ectopic expression of any copy of Bna.C09.AGL11, Bna.A03.AGL11, and Bna.A09.AGL11 in A. thaliana led to smaller and curly leaves and promoted leaf senescence.	2-Naphthylamine	58-61	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	66-71
1792953-4	1991	Conversely, in the thalamic lesion group (superficial pain dominant), thalamic BNA was higher in CL than in Vim, and markedly decreased in VC.	2-Naphthylamine	79-82	vimentin	Homo sapiens	108-111
2060039-5	1991	On the contrary, polycyclic aromatic hydrocarbons, polychlorinated biphenyls (Arochlor 1254) and 2-naphthylamine produced a remarkable increase of ALDH.	2-Naphthylamine	97-112	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	147-151