PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24947467-2	2014	For five P-gp substrates (indinavir, quinidine, loperamide, paclitaxel, and verapamil) and one nonsubstrate (diazepam), in vitro P-gp transport activities were determined by measuring transcellular transport across monolayers of cynomolgus monkey P-gp-transfected LLC-PK1 and parental cells.	Diazepam	109-117	phosphoglycolate phosphatase	Homo sapiens	129-133
24947467-2	2014	For five P-gp substrates (indinavir, quinidine, loperamide, paclitaxel, and verapamil) and one nonsubstrate (diazepam), in vitro P-gp transport activities were determined by measuring transcellular transport across monolayers of cynomolgus monkey P-gp-transfected LLC-PK1 and parental cells.	Diazepam	109-117	phosphoglycolate phosphatase	Homo sapiens	129-133
24629451-13	2014	Diazepam alone was associated with increased concentrations of all cytokines except IL-6.	Diazepam	0-8	interleukin 6	Rattus norvegicus	84-88
25031079-6	2014	We report that curcumin has shown comparable binding affinity value vis-a-vis standard, the accessible surface area (ASA) of human serum albumin (uncomplexed) and its docked complex with curcumin at both binding sites was calculated and found to be close to that of warfarin and diazepam respectively.	Diazepam	279-287	albumin	Homo sapiens	131-144
24797330-0	2014	Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment.	Diazepam	106-114	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-19
24797330-8	2014	The diazepam treatment significantly reduced the stress-induced Fos expression in many brain regions including the prefrontal, sensory and motor cortices, septum, medial amygdaloid nucleus, medial and lateral preoptic areas, parvicellular paraventricular hypothalamic nucleus, dorsomedial hypothalamus, perifornical nucleus, tuberomammillary nucleus, association, midline and intralaminar thalami, and median and dorsal raphe nuclei.	Diazepam	4-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-67
24797330-9	2014	In contrast, diazepam increased Fos-IR cells in the central amygdaloid nucleus, medial habenular nucleus, ventromedial hypothalamic nucleus and magnocellular lateral hypothalamus.	Diazepam	13-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-35
24709118-0	2014	KCC2 expression changes in Diazepam-treated neonatal rats with hypoxia-ischaemia brain damage.	Diazepam	27-35	solute carrier family 12 member 5	Rattus norvegicus	0-4
24531568-4	2014	OBJECTIVES: In the current study, we examined whether subchronic zolpidem or diazepam administration produced deficits in zolpidem"s locomotor-impairing effects, anxiety-like behaviors, and changes in GABAAR subunit messenger RNA (mRNA).	Diazepam	77-85	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	201-207
24531568-9	2014	In addition, we found that subchronic treatment of zolpidem and diazepam induced distinct but overlapping GABAAR subunit mRNA changes in the cortex but few changes in the hippocampus, amygdala, or prefrontal cortex.	Diazepam	64-72	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	106-112
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Diazepam	218-226	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	17-22
24500275-2	2014	Cytochrome P450 (CYP) 3A4 and 2C19 metabolize diazepam into the active metabolites: nordiazepam, temazepam and oxazepam.	Diazepam	46-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-34
24403586-6	2014	Notably, when NKR cells were treated with TSPO antagonist PK-11195, Ro5-4864, or diazepam, HIV restriction was completely disrupted, and TSPO knockdown by short hairpin RNAs (shRNAs) achieved a similar effect.	Diazepam	81-89	killer cell lectin like receptor B1	Homo sapiens	14-17
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Diazepam	218-226	solute carrier family 22 member 3	Homo sapiens	18-22
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Diazepam	218-226	solute carrier family 22 member 3	Homo sapiens	39-44
23982114-9	2014	The half maximal inhibitory concentrations of mOCT3 and hOCT3 for TPA(+), serotonin, diazepam, and ketamine are significantly different.	Diazepam	85-93	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	46-51
23982114-9	2014	The half maximal inhibitory concentrations of mOCT3 and hOCT3 for TPA(+), serotonin, diazepam, and ketamine are significantly different.	Diazepam	85-93	solute carrier family 22 member 3	Homo sapiens	56-61
23478657-15	2013	Functionally diazepam appeared to counteract the endogenous down-regulation of GABAA signaling during infection.	Diazepam	13-21	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	79-84
23963779-9	2013	Next, we evaluated the expression of the diazepam-binding inhibitor (DBI) protein and found that the cells expressed DBI in soma and on the surface of cell membrane.	Diazepam	41-49	diazepam binding inhibitor	Mus musculus	69-72
23963779-9	2013	Next, we evaluated the expression of the diazepam-binding inhibitor (DBI) protein and found that the cells expressed DBI in soma and on the surface of cell membrane.	Diazepam	41-49	diazepam binding inhibitor	Mus musculus	117-120
23175271-1	2013	A rapid and sensitive flow-injection chemiluminescence (FI-CL) method is described for the determination of diazepam based on its reaction with N-bromosuccinimide (NBS) in alkaline medium in the presence of dichlorofluorescein (DCF) as an effective energy-transfer agent.	Diazepam	108-116	nibrin	Homo sapiens	164-167
22918984-4	2013	Prolonged treatment of the slice cultures with diazepam or a GABAA receptor antagonist disclosed a homeostatic regulation of both inhibitory synaptic strength and gephyrin cluster size and stability in 4-weeks-old cultures, whereas at 1 week in vitro, the same drug treatments modulated GABAergic postsynapse and gephyrin cluster properties following a Hebbian mode of synaptic plasticity.	Diazepam	47-55	gephyrin	Mus musculus	163-171
22918984-4	2013	Prolonged treatment of the slice cultures with diazepam or a GABAA receptor antagonist disclosed a homeostatic regulation of both inhibitory synaptic strength and gephyrin cluster size and stability in 4-weeks-old cultures, whereas at 1 week in vitro, the same drug treatments modulated GABAergic postsynapse and gephyrin cluster properties following a Hebbian mode of synaptic plasticity.	Diazepam	47-55	gephyrin	Mus musculus	313-321
23881097-7	2013	A low dose of diazepam promotes eFS in P13-P14 rat pups, whereas seizures are blocked at higher concentrations that suppress breathing.	Diazepam	14-22	SUB1 regulator of transcription	Rattus norvegicus	43-46
23698091-9	2013	Analysis of cultured Baiap3 KO hypothalamus slices revealed an increase in basal network activity and an altered response to diazepam withdrawal.	Diazepam	125-133	BAI1 associated protein 3	Homo sapiens	21-27
23478657-16	2013	Consistent with augmented GABAA signaling, diazepam provoked intracellular acidosis in macrophage, leading to impaired cytokine production, bacterial phagocytosis and killing.	Diazepam	43-51	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	26-31
23451919-6	2013	In adult mice, diazepam treatment affected the distribution of cortical interneurons that express parvalbumin or calretinin, and also led to a decrease in the numbers of calretinin-expressing interneurons.	Diazepam	15-23	parvalbumin	Mus musculus	98-109
24029579-7	2013	And the mechanism of sedative-hypnotic diazepam may be operate through an up-regulation of KCC2, a down-regulation of NKCC1 and decreased [Cl(-)]i.	Diazepam	39-47	solute carrier family 12 member 5	Rattus norvegicus	91-95
24029579-7	2013	And the mechanism of sedative-hypnotic diazepam may be operate through an up-regulation of KCC2, a down-regulation of NKCC1 and decreased [Cl(-)]i.	Diazepam	39-47	solute carrier family 12 member 2	Rattus norvegicus	118-123
23396146-2	2013	It was shown that acute doses of diazepam (DZ; 1 and 2 mg/kg) and flunitrazepam (FNZ; 0.05, 0.1 and 0.2 mg/kg) significantly increased the time of transfer latency (TL2) in a retention trial, thus confirming memory impairing effects of BZs.	Diazepam	33-41	brachyury, T-box transcription factor T	Mus musculus	165-168
23396146-2	2013	It was shown that acute doses of diazepam (DZ; 1 and 2 mg/kg) and flunitrazepam (FNZ; 0.05, 0.1 and 0.2 mg/kg) significantly increased the time of transfer latency (TL2) in a retention trial, thus confirming memory impairing effects of BZs.	Diazepam	43-45	brachyury, T-box transcription factor T	Mus musculus	165-168
23451919-6	2013	In adult mice, diazepam treatment affected the distribution of cortical interneurons that express parvalbumin or calretinin, and also led to a decrease in the numbers of calretinin-expressing interneurons.	Diazepam	15-23	calbindin 2	Mus musculus	113-123
23451919-6	2013	In adult mice, diazepam treatment affected the distribution of cortical interneurons that express parvalbumin or calretinin, and also led to a decrease in the numbers of calretinin-expressing interneurons.	Diazepam	15-23	calbindin 2	Mus musculus	170-180
23352481-1	2013	The 18 kDa translocator protein (TSPO) was identified as a discrete receptor for diazepam (1).	Diazepam	81-89	translocator protein	Homo sapiens	11-31
22891744-0	2013	Diazepam reverses the alveolar bone loss and hippocampal interleukin-1beta and interleukin-6 enhanced by conditioned fear stress in ligature-induced periodontal disease in rats.	Diazepam	0-8	interleukin 1 beta	Rattus norvegicus	57-74
22891744-0	2013	Diazepam reverses the alveolar bone loss and hippocampal interleukin-1beta and interleukin-6 enhanced by conditioned fear stress in ligature-induced periodontal disease in rats.	Diazepam	0-8	interleukin 6	Rattus norvegicus	79-92
22891744-11	2013	In addition, diazepam treatment led to decreased IL-1beta and IL-6 levels in the hippocampus.	Diazepam	13-21	interleukin 1 beta	Rattus norvegicus	49-57
22891744-11	2013	In addition, diazepam treatment led to decreased IL-1beta and IL-6 levels in the hippocampus.	Diazepam	13-21	interleukin 6	Rattus norvegicus	62-66
23360771-4	2013	Here we investigate how two distinct anxiolytic agents, buspirone, a partial 5-HT(1A) agonist, and diazepam, a benzodiazepine, influence phosphorylation of GluA1 subunits of AMPA receptors at the potentiating residue Ser(845) and Ser(831) in corticolimbic regions.	Diazepam	99-107	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	156-161
23352481-1	2013	The 18 kDa translocator protein (TSPO) was identified as a discrete receptor for diazepam (1).	Diazepam	81-89	translocator protein	Homo sapiens	33-37
23392308-9	2013	The mRNA expression levels of mGluR2 and mGluR3 were lowered in the cerebral cortex of mice pretreated with diazepam or alprazolam.	Diazepam	108-116	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	30-36
23266380-8	2013	Diazepam attenuated the NECA-induced expression of mRNA encoding for interleukin-8.	Diazepam	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	69-82
23392308-9	2013	The mRNA expression levels of mGluR2 and mGluR3 were lowered in the cerebral cortex of mice pretreated with diazepam or alprazolam.	Diazepam	108-116	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	41-47
21919687-3	2012	In the current study, in vitro and in vivo inhibition effects of benzodiazepine drugs, diazepam and midazolam, on human erythrocytes carbonic anhydrase I and II isozymes were investigated.	Diazepam	87-95	carbonic anhydrase 1	Homo sapiens	133-153
22765995-3	2012	Furthermore, the expression of interleukin-1 and tumor necrosis factor-alpha was assessed in control animals and psychological stress (PS) and stress with diazepam (PS+DI) groups.	Diazepam	155-163	tumor necrosis factor	Rattus norvegicus	31-76
22648560-8	2012	This was confirmed after the incubation of the individual PPIs with human primary hepatocytes (in the presence of human serum) and by monitoring their impact on diazepam N-demethylase activity at a low concentration of diazepam (2 muM).	Diazepam	219-227	latexin	Homo sapiens	231-234
22169949-7	2012	Muscimol, a GABA(A) receptor agonist, and diazepam, an agonist to benzodiazepine-binding site of GABA(A) receptor, blocked retention trial-induced ERK phosphorylation and impaired memory retrieval.	Diazepam	42-50	mitogen-activated protein kinase 1	Mus musculus	147-150
22487868-8	2012	However, after combination therapy with diazepam and mild hypothermia for 8h, the expression of GluR1 was decreased and GluR2 was increased relative to the levels of diazepam alone treated juveniles.	Diazepam	40-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
22487868-8	2012	However, after combination therapy with diazepam and mild hypothermia for 8h, the expression of GluR1 was decreased and GluR2 was increased relative to the levels of diazepam alone treated juveniles.	Diazepam	40-48	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	120-125
22465203-4	2012	In contrast, while administration of diazepam and chlordiazepoxide significantly attenuated fear-potentiated startle (FPS) in wild type mice and alpha3(H126R) mice, the fear-reducing effects of these drugs were absent in both alpha1(H101R) and alpha2(H101R) point mutants, indicating that both alpha1- and alpha2-containing GABA(A) receptors are necessary for BZs to exert their effects on conditioned fear responses.	Diazepam	37-45	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	145-150
22534198-3	2012	Under oxic conditions, the degradation of DZP achieved 96% after 60 min using Fe(0) (25 g L(-1)) pre-treated with H(2)SO(4) in the presence of EDTA (119 mg L(-1)), while mineralization achieved around 60% after the same time.	Diazepam	42-45	immunoglobulin kappa variable 1-16	Homo sapiens	90-95
22517499-5	2012	Herein, we report the study of the Diels-Alder cycloaddition between 1,3-butadiene and all nonequivalent bonds of the Ti(2)C(2)@D(3h)-C(78) metallic carbide endohedral metallofullerene (EMF) at the BP86/TZP//BP86/DZP level of theory.	Diazepam	213-216	PHD finger protein 20	Homo sapiens	203-206
22344744-0	2012	Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress.	Diazepam	24-32	brain derived neurotrophic factor	Homo sapiens	73-106
22344744-7	2012	RESULTS: Plasma BDNF levels under the placebo, diazepam, and tandospirone conditions significantly decreased after the DS task compared with before the task.	Diazepam	47-55	brain derived neurotrophic factor	Homo sapiens	16-20
22226778-2	2012	Here we show the feasibility of a novel drug delivery system (DDS), utilizing L-PGDS, for poorly water-soluble compounds such as diazepam (DZP), a major benzodiazepine anxiolytic drug, and 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione (NBQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and anticonvulsant.	Diazepam	129-137	prostaglandin D2 synthase (brain)	Mus musculus	78-84
22226778-2	2012	Here we show the feasibility of a novel drug delivery system (DDS), utilizing L-PGDS, for poorly water-soluble compounds such as diazepam (DZP), a major benzodiazepine anxiolytic drug, and 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione (NBQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and anticonvulsant.	Diazepam	139-142	prostaglandin D2 synthase (brain)	Mus musculus	78-84
22226778-5	2012	L-PGDS of 500muM increased the solubility of DZP and NBQX 7- and 2-fold, respectively, compared to PBS alone.	Diazepam	45-48	prostaglandin D2 synthase (brain)	Mus musculus	0-6
22534198-3	2012	Under oxic conditions, the degradation of DZP achieved 96% after 60 min using Fe(0) (25 g L(-1)) pre-treated with H(2)SO(4) in the presence of EDTA (119 mg L(-1)), while mineralization achieved around 60% after the same time.	Diazepam	42-45	immunoglobulin kappa variable 1-16	Homo sapiens	156-161
22366010-6	2012	The model group showed significantly diminished GABAA receptor-positive cells and increased NMDAR1-positive cells, which were improved by diazepam and ASF at the medium dose.	Diazepam	138-146	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	92-98
22128345-8	2012	Consequently, the effect of DZP on PRIP-1 knockout mice was reduced.	Diazepam	28-31	phospholipase C-like 1	Mus musculus	35-41
23030612-7	2012	Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans.	Diazepam	179-187	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
21835188-7	2012	Functional mapping of neuronal activity using c-Fos revealed hyper-excitability in the PVN of anxious Mg(2+) deficient mice and its normalisation through diazepam treatment.	Diazepam	154-162	FBJ osteosarcoma oncogene	Mus musculus	46-51
22210490-0	2012	Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study.	Diazepam	99-107	FBJ osteosarcoma oncogene	Mus musculus	111-116
21402137-3	2011	MDMA significantly inhibited hPXR-mediated CYP3A4-reporter gene expression induced by the human PXR activator rifampicin (IC50 1.26 +- 0.36 mM) or the therapeutic drugs paroxetine, fluoxetine, clozapine, diazepam and risperidone.	Diazepam	204-212	nuclear receptor subfamily 1 group I member 2	Homo sapiens	29-33
21978215-6	2011	Intraperitoneal injection of diazepam, an anxiolytic agent, but not indomethacin, an antipyretic, significantly reduced both the stress-induced hyperthermia and Fos expression in these medullary raphe neuronal populations.	Diazepam	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	161-164
21487654-5	2011	In a control experiment, the effect of diazepam (4.0 mg/kg) on the expression of FPS was tested in HAP2 and LAP2 mice.	Diazepam	39-47	leucine aminopeptidase 2, serum	Mus musculus	108-112
21487654-8	2011	Diazepam reduced FPS to a similar extent in both HAP2 and LAP2 mice.	Diazepam	0-8	leucine aminopeptidase 2, serum	Mus musculus	58-62
21561750-7	2011	In addition, the activity of hippocampal GAD(65) of honokiol treated mice was significantly increased than that of the vehicle or diazepam treated groups.	Diazepam	130-138	glutamic acid decarboxylase 2	Mus musculus	41-48
21699965-6	2011	Diazepam at anaesthetic concentrations (25-500 muM) impeded spontaneous network activity in a concentration dependent manner (EC50 80.5+-8.0 muM).	Diazepam	0-8	latexin	Homo sapiens	47-50
21699965-6	2011	Diazepam at anaesthetic concentrations (25-500 muM) impeded spontaneous network activity in a concentration dependent manner (EC50 80.5+-8.0 muM).	Diazepam	0-8	latexin	Homo sapiens	141-144
21699965-7	2011	In the presence of 1 muM acetylcholine the potency of diazepam was not significantly altered (EC50 83.6+-8.4 muM).	Diazepam	54-62	latexin	Homo sapiens	21-24
21636214-9	2011	Hyperalgesia and c-Fos overexpression were blocked only by prestress treatment with diazepam and post-stress treatment with ketamine, whereas changes in GABA and glutamate release were reversed by prestress treatment with diazepam.	Diazepam	84-92	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
22018687-6	2011	On the contrary, a higher dose of diazepam (>2mg/kg) alone was found to be a sedative or locomotor depressant, indicating that the anxiolytic effect of diazepam, at least in part involve TRPV1 receptor.	Diazepam	34-42	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	190-195
21900575-7	2011	Coadministration of diazepam or MK-801 with PTZ inhibited the development of kindling and the increased MMP-9 levels in the hippocampus.	Diazepam	20-28	matrix metallopeptidase 9	Mus musculus	104-109
21561794-4	2011	Results demonstrated that diazepam, triazolam, amitriptyline, mianserin, malathion, fenitrothion, chlorpyrifosmethyl, and probenecid significantly inhibited representative substrates of hOAT1 and para-aminohippuric acid uptake by hOAT1.	Diazepam	26-34	solute carrier family 22 member 6	Homo sapiens	186-191
21561794-4	2011	Results demonstrated that diazepam, triazolam, amitriptyline, mianserin, malathion, fenitrothion, chlorpyrifosmethyl, and probenecid significantly inhibited representative substrates of hOAT1 and para-aminohippuric acid uptake by hOAT1.	Diazepam	26-34	solute carrier family 22 member 6	Homo sapiens	230-235
21557446-0	2011	Binding of delta9-tetrahydrocannabinol and diazepam to human serum albumin.	Diazepam	43-51	albumin	Homo sapiens	61-74
21557446-3	2011	Here, Delta9-tetrahydrocannabinol (THC) and diazepam binding to human serum albumin (HSA) and HSA-heme is reported.	Diazepam	44-52	albumin	Homo sapiens	70-83
21511007-6	2011	Contextually, DZP was also responsible for a very great up-regulated expression of neuritic NR1 and MAP2 together with a great (p<0.01) increase of synaptophysin at DIV7.	Diazepam	14-17	microtubule-associated protein 2	Mesocricetus auratus	100-104
21511007-6	2011	Contextually, DZP was also responsible for a very great up-regulated expression of neuritic NR1 and MAP2 together with a great (p<0.01) increase of synaptophysin at DIV7.	Diazepam	14-17	synaptophysin	Mesocricetus auratus	151-164
21402137-3	2011	MDMA significantly inhibited hPXR-mediated CYP3A4-reporter gene expression induced by the human PXR activator rifampicin (IC50 1.26 +- 0.36 mM) or the therapeutic drugs paroxetine, fluoxetine, clozapine, diazepam and risperidone.	Diazepam	204-212	nuclear receptor subfamily 1 group I member 2	Homo sapiens	30-33
21480876-12	2011	SIGNIFICANCE: DZP and KBr showed potent inhibitory effects against hyperthermia-induced seizures in the Scn1a mutant rats, whereas CBZ exhibited adverse effects.	Diazepam	14-17	sodium voltage-gated channel alpha subunit 1	Rattus norvegicus	104-109
21277878-9	2011	Importantly, the reduced inhibition also operated to enhance NMDARs functions after peripheral inflammation, because spinal injection of diazepam to rescue the inhibition in inflamed mice greatly depressed PKA phosphorylation of NR1-S897, reduced the synaptic concentration of NR1/NR2B and meanwhile, alleviated the inflammatory pain.	Diazepam	137-145	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	229-232
21277878-9	2011	Importantly, the reduced inhibition also operated to enhance NMDARs functions after peripheral inflammation, because spinal injection of diazepam to rescue the inhibition in inflamed mice greatly depressed PKA phosphorylation of NR1-S897, reduced the synaptic concentration of NR1/NR2B and meanwhile, alleviated the inflammatory pain.	Diazepam	137-145	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	277-280
21277878-9	2011	Importantly, the reduced inhibition also operated to enhance NMDARs functions after peripheral inflammation, because spinal injection of diazepam to rescue the inhibition in inflamed mice greatly depressed PKA phosphorylation of NR1-S897, reduced the synaptic concentration of NR1/NR2B and meanwhile, alleviated the inflammatory pain.	Diazepam	137-145	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	281-285
21732488-10	2011	Finally, we show that as in in vitro also in in vivo a short administration of diazepam promotes EGFR expression in prominin(+) stem cells causing activation and cell cycle entry.	Diazepam	79-87	epidermal growth factor receptor	Mus musculus	97-101
21282931-0	2011	Diazepam enhances production of diazepam-binding inhibitor (DBI), a negative saliva secretion regulator, localized in rat salivary gland.	Diazepam	0-8	diazepam binding inhibitor	Rattus norvegicus	32-58
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Diazepam	125-133	translocator protein	Homo sapiens	13-33
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Diazepam	125-133	translocator protein	Homo sapiens	35-39
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Diazepam	125-133	translocator protein	Homo sapiens	144-184
21291396-1	2011	The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)".	Diazepam	125-133	translocator protein	Homo sapiens	186-189
21282931-0	2011	Diazepam enhances production of diazepam-binding inhibitor (DBI), a negative saliva secretion regulator, localized in rat salivary gland.	Diazepam	0-8	diazepam binding inhibitor	Rattus norvegicus	60-63
21282931-3	2011	In this study, we investigated the effect of repetitive administration of diazepam (DZP) on salivary secretion and expression of DBI mRNA and peptide.	Diazepam	74-82	diazepam binding inhibitor	Rattus norvegicus	129-132
21282931-3	2011	In this study, we investigated the effect of repetitive administration of diazepam (DZP) on salivary secretion and expression of DBI mRNA and peptide.	Diazepam	84-87	diazepam binding inhibitor	Rattus norvegicus	129-132
21282931-4	2011	Moreover, mRNA expression of PBR and pituitary adenylate cyclase-activating polypeptide (PACAP), a transcriptional regulator for DBI promoter, was evaluated after repetitive administration of DZP.	Diazepam	192-195	adenylate cyclase activating polypeptide 1	Rattus norvegicus	37-87
21282931-4	2011	Moreover, mRNA expression of PBR and pituitary adenylate cyclase-activating polypeptide (PACAP), a transcriptional regulator for DBI promoter, was evaluated after repetitive administration of DZP.	Diazepam	192-195	adenylate cyclase activating polypeptide 1	Rattus norvegicus	89-94
21282931-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	diazepam binding inhibitor	Rattus norvegicus	142-145
21282931-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	adenylate cyclase activating polypeptide 1	Rattus norvegicus	147-152
21282931-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	translocator protein	Rattus norvegicus	158-161
21282931-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	diazepam binding inhibitor	Rattus norvegicus	224-227
21282931-6	2011	These results suggest that repetitive administration of DZP stimulates DBI production, which may result in an increase in the suppressive effect of DZP on salivary secretion.	Diazepam	56-59	diazepam binding inhibitor	Rattus norvegicus	71-74
32272540-0	2011	Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland.	Diazepam	0-8	diazepam binding inhibitor	Rattus norvegicus	32-58
21720097-0	2011	Possible underlying influence of p38MAPK and NF-kappaB in the diminished anti-anxiety effect of diazepam in stressed mice.	Diazepam	96-104	mitogen-activated protein kinase 14	Mus musculus	33-40
21282931-6	2011	These results suggest that repetitive administration of DZP stimulates DBI production, which may result in an increase in the suppressive effect of DZP on salivary secretion.	Diazepam	148-151	diazepam binding inhibitor	Rattus norvegicus	71-74
32272540-0	2011	Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland.	Diazepam	0-8	diazepam binding inhibitor	Rattus norvegicus	60-63
20943906-5	2010	PAM(+/-) mice presented with anxiety-like behaviors in the zero maze that were alleviated by diazepam.	Diazepam	93-101	peptidylglycine alpha-amidating monooxygenase	Mus musculus	0-3
32272540-3	2011	In this study, we investigated the effect of repetitive administration of diazepam (DZP) on salivary secretion and expression of DBI mRNA and peptide.	Diazepam	74-82	diazepam binding inhibitor	Rattus norvegicus	129-132
32272540-3	2011	In this study, we investigated the effect of repetitive administration of diazepam (DZP) on salivary secretion and expression of DBI mRNA and peptide.	Diazepam	84-87	diazepam binding inhibitor	Rattus norvegicus	129-132
32272540-4	2011	Moreover, mRNA expression of PBR and pituitary adenylate cyclase-activating polypeptide (PACAP), a transcriptional regulator for DBI promoter, was evaluated after repetitive administration of DZP.	Diazepam	192-195	adenylate cyclase activating polypeptide 1	Rattus norvegicus	37-87
32272540-4	2011	Moreover, mRNA expression of PBR and pituitary adenylate cyclase-activating polypeptide (PACAP), a transcriptional regulator for DBI promoter, was evaluated after repetitive administration of DZP.	Diazepam	192-195	adenylate cyclase activating polypeptide 1	Rattus norvegicus	89-94
32272540-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	diazepam binding inhibitor	Rattus norvegicus	142-145
32272540-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	adenylate cyclase activating polypeptide 1	Rattus norvegicus	147-152
32272540-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	translocator protein	Rattus norvegicus	158-161
32272540-5	2011	Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide.	Diazepam	71-74	diazepam binding inhibitor	Rattus norvegicus	224-227
32272540-6	2011	These results suggest that repetitive administration of DZP stimulates DBI production, which may result in an increase in the suppressive effect of DZP on salivary secretion.	Diazepam	56-59	diazepam binding inhibitor	Rattus norvegicus	71-74
32272540-6	2011	These results suggest that repetitive administration of DZP stimulates DBI production, which may result in an increase in the suppressive effect of DZP on salivary secretion.	Diazepam	148-151	diazepam binding inhibitor	Rattus norvegicus	71-74
20846531-10	2010	Diazepam effects were discussed as being related to the number of TSPO sites present on immune cells and/or to the increased levels of serum corticosterone observed after the treatments used.	Diazepam	0-8	translocator protein	Rattus norvegicus	66-70
21720097-0	2011	Possible underlying influence of p38MAPK and NF-kappaB in the diminished anti-anxiety effect of diazepam in stressed mice.	Diazepam	96-104	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	45-54
21720097-1	2011	The present study was designed to explore the possible nitriergic influence and role of p38MAPK and NF-kappaB in the diminished anti-anxiety effect of diazepam in stressed mice, using the elevated plus maze and light/dark box to assess anxiety.	Diazepam	151-159	mitogen-activated protein kinase 14	Mus musculus	88-95
21720097-1	2011	The present study was designed to explore the possible nitriergic influence and role of p38MAPK and NF-kappaB in the diminished anti-anxiety effect of diazepam in stressed mice, using the elevated plus maze and light/dark box to assess anxiety.	Diazepam	151-159	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-109
21720097-15	2011	The observations indicate that the diminished anti-anxiety effect of diazepam in stressed mice may involve strong nitriergic influence and may further be p38MAPK- and NF-kappaB-dependent.	Diazepam	69-77	mitogen-activated protein kinase 14	Mus musculus	154-161
21720097-15	2011	The observations indicate that the diminished anti-anxiety effect of diazepam in stressed mice may involve strong nitriergic influence and may further be p38MAPK- and NF-kappaB-dependent.	Diazepam	69-77	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-176
20670676-10	2010	Neurosteroid withdrawal-induced seizure exacerbation, diazepam insensitivity, and flumazenil efficacy in the kindling model were reversed by inhibition of Egr3.	Diazepam	54-62	early growth response 3	Mus musculus	155-159
20095803-2	2010	This effect was attributed to an action of diazepam on the Translocator Protein (TSPO).	Diazepam	43-51	translocator protein	Rattus norvegicus	59-79
20605909-12	2010	Together, our findings suggest that selective DOR agonists can decrease anxiety-like behavior and are more effective than diazepam at reducing ethanol consumption.	Diazepam	122-130	opioid receptor, delta 1	Mus musculus	46-49
20468063-1	2010	Cytochrome P450 2C19 (CYP2C19) is a polymorphic enzyme active in the metabolism of for example diazepam and the antidepressants sertraline, citalopram, and escitalopram, whereby allelic variants cause increased (CYP2C19*17) or abolished (mainly CYP2C19*2) enzymatic activity in drug metabolism.	Diazepam	95-103	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-20
20468063-1	2010	Cytochrome P450 2C19 (CYP2C19) is a polymorphic enzyme active in the metabolism of for example diazepam and the antidepressants sertraline, citalopram, and escitalopram, whereby allelic variants cause increased (CYP2C19*17) or abolished (mainly CYP2C19*2) enzymatic activity in drug metabolism.	Diazepam	95-103	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	22-29
20468063-1	2010	Cytochrome P450 2C19 (CYP2C19) is a polymorphic enzyme active in the metabolism of for example diazepam and the antidepressants sertraline, citalopram, and escitalopram, whereby allelic variants cause increased (CYP2C19*17) or abolished (mainly CYP2C19*2) enzymatic activity in drug metabolism.	Diazepam	95-103	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	212-219
20468063-1	2010	Cytochrome P450 2C19 (CYP2C19) is a polymorphic enzyme active in the metabolism of for example diazepam and the antidepressants sertraline, citalopram, and escitalopram, whereby allelic variants cause increased (CYP2C19*17) or abolished (mainly CYP2C19*2) enzymatic activity in drug metabolism.	Diazepam	95-103	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	212-219
20095803-2	2010	This effect was attributed to an action of diazepam on the Translocator Protein (TSPO).	Diazepam	43-51	translocator protein	Rattus norvegicus	81-85
20514481-5	2010	Ultrasound-induced c-Fos expression was measured in different periaqueductal gray (PAG) and amygdala subregions after treatment with diazepam or Ro 64-6198.	Diazepam	133-141	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	19-24
20600432-8	2010	Post-trial treatments with SP 1-11, SP 1-7 or ChCl blocked the amnesic effects of SCP and DZP.	Diazepam	90-93	Sp1 transcription factor	Rattus norvegicus	27-34
20514481-8	2010	Diazepam, but not Ro 64-6198, reduced c-Fos expression in the dPAG/dlPAG, while Ro 64-6198, but not diazepam, reduced c-Fos expression in the central amygdala.	Diazepam	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-43
20535452-4	2010	RESULTS: The 5-HT(1A) receptor antagonist WAY-100635 (0.1-1 mg/kg) reversed the SIH-reducing effects of the non-alpha-subunit selective GABA(A) receptor agonist diazepam (1-4 mg/kg) and the GABA(A) receptor alpha(3)-subunit selective agonist TP003 (1 mg/kg), whereas WAY-100635 alone was without effect on the SIH response or basal body temperature.	Diazepam	161-169	5-hydroxytryptamine receptor 1A	Homo sapiens	13-30
19914403-0	2010	Suppressive effect of diazepam on IFN-gamma production by human T cells.	Diazepam	22-30	interferon gamma	Homo sapiens	34-43
20452969-1	2010	Acyl-CoA-binding protein (ACBP) functions both intracellularly as part of fatty acid metabolism and extracellularly as diazepam binding inhibitor, the precursor of endozepine peptides.	Diazepam	119-127	diazepam binding inhibitor	Mus musculus	0-24
20452969-1	2010	Acyl-CoA-binding protein (ACBP) functions both intracellularly as part of fatty acid metabolism and extracellularly as diazepam binding inhibitor, the precursor of endozepine peptides.	Diazepam	119-127	diazepam binding inhibitor	Mus musculus	26-30
20473033-4	2010	One such protein is an evolutionarily conserved, secreted Acyl-CoA binding protein (known as AcbA in Dictyostelium discoideum, Acb1 in yeast and diazepam-binding inhibitor in mammals).	Diazepam	145-153	long-chain fatty acid transporter ACB1	Saccharomyces cerevisiae S288C	127-131
20412381-3	2010	The alpha subunit affects diazepam sensitivity; alpha1, 2, 3, and 5 subunits assemble with any form of beta and the gamma2 subunits to produce diazepam-sensitive receptors, whereas alpha4 or alpha6/beta/gamma2 receptors are diazepam-insensitive.	Diazepam	143-151	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	48-60
20412381-3	2010	The alpha subunit affects diazepam sensitivity; alpha1, 2, 3, and 5 subunits assemble with any form of beta and the gamma2 subunits to produce diazepam-sensitive receptors, whereas alpha4 or alpha6/beta/gamma2 receptors are diazepam-insensitive.	Diazepam	143-151	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	116-122
20412381-4	2010	Here, we investigated how PRIP is implicated in the diazepam-insensitive phenotype using cerebellar granule cells in animals expressing predominantly the alpha6 subunit.	Diazepam	52-60	phospholipase C-like 1	Mus musculus	26-30
20412381-9	2010	PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells.	Diazepam	38-46	phospholipase C-like 1	Mus musculus	0-12
20412381-9	2010	PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells.	Diazepam	94-102	phospholipase C-like 1	Mus musculus	0-12
20412381-9	2010	PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells.	Diazepam	94-102	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	114-127
20412381-9	2010	PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells.	Diazepam	94-102	phospholipase C-like 1	Mus musculus	0-12
20412381-9	2010	PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells.	Diazepam	94-102	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	114-127
20609063-12	2010	CONCLUSIONS: The obtained results suggest that the preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduced the anticonvulsant action of phenytoin and significantly increased the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model.	Diazepam	216-224	prostaglandin-endoperoxide synthase 2	Mus musculus	64-80
20083184-6	2010	DZP of 10 microM significantly increased expression of GABA(A) receptor subunit alpha1, alpha5 and decreased expression of beta2 at 24h treatment, and decreased alpha1, alpha5, beta2 subunits gene expression at 72h treatment.	Diazepam	0-3	gamma-aminobutyric acid type A receptor subunit alpha 1	Rattus norvegicus	55-86
19914403-2	2010	In the present study, we revealed that diazepam, a mixed-type benzodiazepine, inhibited IFN-gamma production by human peripheral blood mononuclear cells (PBMCs) induced by anti-CD3 in dose-dependent manner.	Diazepam	39-47	interferon gamma	Homo sapiens	88-97
19914403-3	2010	Flow cytometry analysis demonstrated that diazepam could inhibit the frequency of IFN-gamma-producing CD4(+) and CD8(+) T cells.	Diazepam	42-50	interferon gamma	Homo sapiens	82-91
19914403-4	2010	The inhibitory effect of diazepam on IFN-gamma production is similar to that of R(0)5-4864, a selective PBRs ligand.	Diazepam	25-33	interferon gamma	Homo sapiens	37-46
19905875-6	2010	In conclusion, the time-dependent inhibition of CYP3A4 by diazepam was attenuated by DMSO, while acetonitrile and methanol had no effect.	Diazepam	58-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-54
19898817-11	2010	In contrast, inhibitory effects of diazepam treatment were observed on putative CYP3A enzyme activity and additionally on CYP3A126 mRNA expression.	Diazepam	35-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-85
19452356-5	2010	The expression data show a significant effect of diazepam treatment on synaptophysin expression, which is reversible by SKF89976A treatment.	Diazepam	49-57	synaptophysin	Rattus norvegicus	71-84
19452356-6	2010	CONCLUSIONS: The increased synaptophysin expression in the hippocampus of diazepam-tolerant rats may indicate a role for modulation of transmitter release, synaptic plasticity and learning in pharmacological tolerance.	Diazepam	74-82	synaptophysin	Rattus norvegicus	27-40
19782064-0	2010	Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo.	Diazepam	65-73	translocator protein	Mus musculus	0-20
19782064-2	2010	TSPO drug ligands (e.g., diazepam) induce or inhibit tumor cell proliferation, depending on the dose and tissue origin.	Diazepam	25-33	translocator protein	Mus musculus	0-4
19782064-11	2010	Taken together, these data suggest that diazepam induces in vivo Ehrlich tumor growth in a TSPO-dependent manner.	Diazepam	40-48	translocator protein	Mus musculus	91-95
20164598-3	2010	In this present experimental study, using state-of-the-art nuclear magnetic resonance, we have monitored the influence of a larger sized intravenous anesthetic, diazepam, as well as diazepam co-administered with halothane, on Abeta.	Diazepam	182-190	amyloid beta precursor protein	Homo sapiens	226-231
20164598-5	2010	However, when diazepam was co-administered with halothane, profound Abeta oligomerization is observed.	Diazepam	14-22	amyloid beta precursor protein	Homo sapiens	68-73
20164598-6	2010	These results strengthen the hypothesis that the presence of smaller molecular sized anesthetic is instrumental in promoting Abeta oligomerization even when co-administered with a larger sized anesthetic, namely diazepam.	Diazepam	212-220	amyloid beta precursor protein	Homo sapiens	125-130
19893285-6	2010	By Western blot analysis, constitutive protein expressions of cytochrome P450 (CYP) 2C11, which is responsible for diazepam N-demethylation, were detected in the 4 strain in both the male and female rats, and the BN rats had lower expression levels of CYP2C11 protein.	Diazepam	115-123	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	62-88
19893285-8	2010	Our results suggested that there was a strain difference in CYP-dependent diazepam N-demethylation in the rat kidney, which is different from the finding in liver microsomes.	Diazepam	74-82	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	60-63
19905875-0	2010	Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.	Diazepam	74-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-70
19905875-2	2010	The inactivation kinetics of CYP3A4 by diazepam dissolved in acetonitrile and methanol were almost equal with k(inact)/K(I) values, 0.095 and 0.15 min(-1) mM(-1) for HLM and 1.1 and 1.4 min(-1) mM(-1) for rCYP3A4, respectively.	Diazepam	39-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
19905875-7	2010	The metabolite formation profile under the conditions tested suggested that DMSO competitively inhibit the formation of the reactive metabolites of diazepam by CYP3A4.	Diazepam	148-156	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	160-166
19905875-2	2010	The inactivation kinetics of CYP3A4 by diazepam dissolved in acetonitrile and methanol were almost equal with k(inact)/K(I) values, 0.095 and 0.15 min(-1) mM(-1) for HLM and 1.1 and 1.4 min(-1) mM(-1) for rCYP3A4, respectively.	Diazepam	39-47	oxysterol binding protein 2	Homo sapiens	166-183
19689220-7	2009	The authors conclude that the metabolic capacities and major metabolic pathways of diazepam are quite different among rat strains and in the Wistar strain due to CYP2D3 genetic polymorphism, which is independent of the debrisoquine polymorphism catalyzed by CYP2D2.	Diazepam	83-91	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	162-168
19905875-4	2010	The formation rate of nordiazepam and temazepam metabolized from diazepam dissolved in DMSO were approximately half of those using substrate dissolved in acetonitrile and methanol in both HLM and rCYP3A4.	Diazepam	25-33	oxysterol binding protein 2	Homo sapiens	188-191
19703932-2	2009	Diazepam increases the conductance of some of these native channels but never those of recombinant receptors, unless they are coexpressed with GABARAP.	Diazepam	0-8	GABA type A receptor-associated protein	Homo sapiens	143-150
19703932-5	2009	Here we report that when applied to inside-out patches, a peptide mimicking the MA helix of the gamma2 subunit (gamma(381-403)) of the GABA(A) receptor abrogates the potentiating effect of diazepam on both endogenous receptors and recombinant GABA(A) receptors coexpressed with GABARAP, by substantially reducing their conductance.	Diazepam	189-197	tryptophanyl-tRNA synthetase 1	Homo sapiens	96-102
19703932-5	2009	Here we report that when applied to inside-out patches, a peptide mimicking the MA helix of the gamma2 subunit (gamma(381-403)) of the GABA(A) receptor abrogates the potentiating effect of diazepam on both endogenous receptors and recombinant GABA(A) receptors coexpressed with GABARAP, by substantially reducing their conductance.	Diazepam	189-197	GABA type A receptor-associated protein	Homo sapiens	278-285
19689220-7	2009	The authors conclude that the metabolic capacities and major metabolic pathways of diazepam are quite different among rat strains and in the Wistar strain due to CYP2D3 genetic polymorphism, which is independent of the debrisoquine polymorphism catalyzed by CYP2D2.	Diazepam	83-91	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	258-264
19523457-1	2009	The in situ brain perfusion technique was used to assess the impact of local capillary density, blood flow rate and P-gp-mediated efflux activity on regional drug exposure for the P-gp substrates colchicine, quinidine, verapamil, and loperamide, the perfusion flow rate marker diazepam, and the vascular volume marker inulin, in mdr1a(+/+) and mdr1a(-/-) mice.	Diazepam	277-285	phosphoglycolate phosphatase	Mus musculus	180-184
19651196-9	2009	Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans.	Diazepam	185-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
19326174-5	2009	Therefore, a randomised controlled trial was conducted to decide whether diazepam would decrease physiological 18F-FDG uptake in the neck and upper chest region (FDG-NUC).	Diazepam	73-81	nucleobindin 1	Homo sapiens	166-169
19775283-10	2009	Western blot analysis showed that tanshinone I reversed the diazepam- and MK-801-induced inhibitions of ERK and CREB activation in hippocampal tissues.	Diazepam	60-68	mitogen-activated protein kinase 1	Mus musculus	104-107
19775283-10	2009	Western blot analysis showed that tanshinone I reversed the diazepam- and MK-801-induced inhibitions of ERK and CREB activation in hippocampal tissues.	Diazepam	60-68	cAMP responsive element binding protein 1	Mus musculus	112-116
19775283-12	2009	CONCLUSIONS AND IMPLICATIONS: Tanshinone I ameliorates the learning and memory impairments induced by diazepam and MK-801 through activation of ERK signalling.	Diazepam	102-110	mitogen-activated protein kinase 1	Mus musculus	144-147
19326174-6	2009	METHODS: A randomised, double-blind, placebo-controlled trial was conducted to assess the effect on FDG-NUC of 5 mg diazepam, given orally 1 h before 18F-FDG injection.	Diazepam	116-124	nucleobindin 1	Homo sapiens	104-107
19326174-12	2009	FDG-NUC was seen in 25% of the patients in the diazepam group versus 29% in the placebo group.	Diazepam	47-55	nucleobindin 1	Homo sapiens	4-7
19371264-1	2009	The ability of obidoxime with atropine and diazepam mixture to reactivate acetylcholinesterase inhibited by the organophosphorus compound chlorfenvinphos was compared in the central nervous system and peripheral tissues of rats.	Diazepam	43-51	acetylcholinesterase	Rattus norvegicus	74-94
19371264-9	2009	The results of the present study show that obidoxime administered separately and jointly with atropine and diazepam 24 hrs after intoxication was effective on reactivation of chlorfenvinphos-inhibited acetylcholinesterase in the central nervous system and in the peripheral tissues.	Diazepam	107-115	acetylcholinesterase	Rattus norvegicus	201-221
19371260-9	2009	Administration of all drugs reduced cell loss in the hippocampus, with best effects observed in brains slices of diazepam-treated animals, which showed less than 30% of loss in the three areas and decreased GFAP immunolabelling.	Diazepam	113-121	glial fibrillary acidic protein	Rattus norvegicus	207-211
19428822-1	2009	The aim of the present investigation was to analyze the molecular mechanism(s) of diazepam neuroprotection in two models of selective neuronal death in CA1 sector of hippocampus: in vivo following transient gerbil brain ischemia and in vitro in rat hippocampal brain slices subjected to glutamatergic (100 microM NMDA) or oxidative (30 microM tertbutyl-hydroksyperoxide (TBH)) stress.	Diazepam	82-90	carbonic anhydrase 1	Rattus norvegicus	152-155
19428822-7	2009	Next, we have shown that diazepam reduced the efflux of cytochrome c out of mitochondria both in compromised CA1 neurons in vitro and in isolated mitochondria treated with 30 microM THB.	Diazepam	25-33	carbonic anhydrase 1	Rattus norvegicus	109-112
19428822-9	2009	We suggest that diazepam evokes neuroprotection through its central receptors located on the GABA(A) receptor complex and, possibly, through its peripheral receptor, the translocator protein TSPO (previously called the peripheral benzodiazepine receptor) located in the outer mitochondrial membrane.	Diazepam	16-24	translocator protein	Rattus norvegicus	191-195
19420124-5	2009	Typical of several drug classes and two cell types, in CA1 pyramidal neurons, the benzodiazepine diazepam doubled the total charge transfer (TCT) of miniature postsynaptic inhibitory currents (mIPSCs), whereas it quadrupled the TCT of tonic currents.	Diazepam	97-105	carbonic anhydrase 1	Rattus norvegicus	55-58
18983865-6	2009	The strong and overlapping inductive role of phenobarbital strengthens the participation of CYP2B6 and CYP3A in diazepam N-demethylation and CYP3A in temazepam formation.	Diazepam	112-120	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-98
19568786-2	2009	We investigated effects of Promethazine, Citalopram, Ziprasidone, Risperidone, and Diazepam on phospholipase A(2) (PLA(2)) and polyphosphoinositide (PPI) metabolism in thrombin-stimulated human platelets.	Diazepam	83-91	phospholipase A2 group IB	Homo sapiens	95-113
19568786-2	2009	We investigated effects of Promethazine, Citalopram, Ziprasidone, Risperidone, and Diazepam on phospholipase A(2) (PLA(2)) and polyphosphoinositide (PPI) metabolism in thrombin-stimulated human platelets.	Diazepam	83-91	phospholipase A2 group IB	Homo sapiens	115-121
19236854-3	2009	Knowing that KCC2 maintains low intracellular Cl(-) concentrations, which drive Cl(-) influx in response to GABA(A) receptor activation, we monitored the behavioural response to the GABA(A) receptor enhancer, diazepam, in mice pre-treated for 7 days with saline or 25 mg/kg of memantine.	Diazepam	209-217	solute carrier family 12, member 5	Mus musculus	13-17
19299782-5	2009	RESULTS: Midazolam, diazepam and flunitrazepam concentration-dependently inhibited UII-evoked norepinephrine release but did not affect [Ca(2+)]i.	Diazepam	20-28	urotensin 2	Rattus norvegicus	83-86
19050992-7	2009	Also like the plant flavonoids, treatment with 10(-6) M concentration of diazepam for 3 days hardly affect the peripheral-type BZD receptor (PBR) messenger RNA (mRNA) expression and inhibited glucose utilization of SNU-C4 cells.	Diazepam	73-81	translocator protein	Homo sapiens	111-139
19050992-7	2009	Also like the plant flavonoids, treatment with 10(-6) M concentration of diazepam for 3 days hardly affect the peripheral-type BZD receptor (PBR) messenger RNA (mRNA) expression and inhibited glucose utilization of SNU-C4 cells.	Diazepam	73-81	translocator protein	Homo sapiens	141-144
19050992-8	2009	Treatment with flavonoids or diazepam for 6 days upregulated PBR mRNA expression and cell cytotoxicity of SNU-C4 cells.	Diazepam	29-37	translocator protein	Homo sapiens	61-64
18971314-4	2009	In our previous study, we determined that a deficiency of CYP2D3 protein, not CYP2D2, was responsible for the inter- and intrastrain differences in diazepam p-hydroxylation (Drug Metab Dispos 33:1657-1660, 2005).	Diazepam	148-156	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	58-64
18971314-6	2009	Nucleotide sequence analysis revealed the insertion of a thymine in exon 8 of the CYP2D3 gene in the poor diazepam metabolizers.	Diazepam	106-114	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	82-88
19022279-0	2009	Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: a comparative study with amphetamine and diazepam.	Diazepam	138-146	neuropeptide S	Mus musculus	0-14
19114084-2	2009	By using real-time PCR, in the present study we investigated whether diazepam elicits gene expression alterations in extracellular matrix (ECM) components, growth factors and gamma-aminobutyric acid receptor (GABRB3), implicated in the coordinate regulation of palate development.	Diazepam	69-77	gamma-aminobutyric acid type A receptor subunit beta3	Homo sapiens	209-215
19091469-0	2009	Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.	Diazepam	37-45	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	73-78
19091469-13	2009	We conclude that systemic diazepam exerts a genuine antihyperalgesic effect, which depends on spinal GABA(A) receptors containing alpha2 and/or alpha3 subunits.	Diazepam	26-34	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	130-150
18983865-6	2009	The strong and overlapping inductive role of phenobarbital strengthens the participation of CYP2B6 and CYP3A in diazepam N-demethylation and CYP3A in temazepam formation.	Diazepam	112-120	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-108
19519385-8	2009	Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans.	Diazepam	179-187	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
19689272-1	2009	The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR), was originally identified as an alternate binding site for the central benzodiazepine receptor (CBR) ligand, diazepam, in the periphery, but has now been distinguished as a novel site.	Diazepam	215-223	translocator protein	Homo sapiens	4-33
19689272-1	2009	The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR), was originally identified as an alternate binding site for the central benzodiazepine receptor (CBR) ligand, diazepam, in the periphery, but has now been distinguished as a novel site.	Diazepam	215-223	translocator protein	Homo sapiens	35-39
19689272-1	2009	The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR), was originally identified as an alternate binding site for the central benzodiazepine receptor (CBR) ligand, diazepam, in the periphery, but has now been distinguished as a novel site.	Diazepam	215-223	translocator protein	Homo sapiens	64-98
19571432-6	2009	When HepG2 cells were infected with adednovirus for CYP3A4 and that for CYP2C19 simultaneously at a ratio of 10:1, the ratio of their apoprotein levels was similar to that observed in human hepatocytes and the metabolic profile of diazepam in the system was almost identical to that observed in hepatocyets.	Diazepam	231-239	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	72-79
19689272-1	2009	The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR), was originally identified as an alternate binding site for the central benzodiazepine receptor (CBR) ligand, diazepam, in the periphery, but has now been distinguished as a novel site.	Diazepam	215-223	translocator protein	Homo sapiens	100-103
19689272-1	2009	The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR), was originally identified as an alternate binding site for the central benzodiazepine receptor (CBR) ligand, diazepam, in the periphery, but has now been distinguished as a novel site.	Diazepam	215-223	cannabinoid receptor 1	Homo sapiens	169-200
19689272-1	2009	The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR), was originally identified as an alternate binding site for the central benzodiazepine receptor (CBR) ligand, diazepam, in the periphery, but has now been distinguished as a novel site.	Diazepam	215-223	cannabinoid receptor 1	Homo sapiens	202-205
19066419-0	2008	Responsiveness of 5-HT2C receptors in repeatedly diazepam-injected rats: a behavioral and neurochemical study.	Diazepam	49-57	5-hydroxytryptamine receptor 2C	Rattus norvegicus	18-24
18834881-0	2008	Diazepam delays the death of hippocampal CA1 neurons following global ischemia.	Diazepam	0-8	carbonic anhydrase 1	Homo sapiens	41-44
18834881-11	2008	Diazepam-treated gerbils exhibited near normal levels of CA1 neurons and MAP2 staining.	Diazepam	0-8	carbonic anhydrase 1	Homo sapiens	57-60
18834881-11	2008	Diazepam-treated gerbils exhibited near normal levels of CA1 neurons and MAP2 staining.	Diazepam	0-8	microtubule associated protein 2	Homo sapiens	73-77
18575801-14	2008	These results demonstrate that endocannabinoid system participates in the modulation of seizure and combination of small doses of exogenous CB1 receptor agonists with diazepam may have effective consequences in seizure control.	Diazepam	167-175	cannabinoid receptor 1 (brain)	Mus musculus	140-143
18846481-8	2008	HepG2-GS-3A4 selectively metabolized substrates of CYP3A4 (diazepam, nordiazepam, lidocaine, atorvastatin, and nifedipine) to a greater degree than control.	Diazepam	59-67	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-57
18706494-0	2008	Methamphetamine and diazepam suppress antigen-specific cytokine expression and antibody production in ovalbumin-sensitized BALB/c mice.	Diazepam	20-28	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	102-111
18706494-7	2008	The results demonstrated that methamphetamine and/or diazepam significantly attenuated the production of OVA-specific IgM, IgG(1) and IgG(2a).	Diazepam	53-61	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	123-129
18706494-7	2008	The results demonstrated that methamphetamine and/or diazepam significantly attenuated the production of OVA-specific IgM, IgG(1) and IgG(2a).	Diazepam	53-61	immunoglobulin heavy variable V1-9	Mus musculus	134-140
18706494-8	2008	Concordantly, splenocytes of mice administered with diazepam and/or methamphetamine produced less IL-4 and IFN-gamma upon ex vivo re-stimulation with OVA, as compared to the vehicle-treated control.	Diazepam	52-60	interleukin 4	Mus musculus	98-102
18706494-8	2008	Concordantly, splenocytes of mice administered with diazepam and/or methamphetamine produced less IL-4 and IFN-gamma upon ex vivo re-stimulation with OVA, as compared to the vehicle-treated control.	Diazepam	52-60	interferon gamma	Mus musculus	107-116
18793688-13	2008	The anxiolytic-like action of diazepam was mimicked by NPS that reduced cumulative burying behavior in a dose dependent manner.	Diazepam	30-38	neuropeptide S	Rattus norvegicus	55-58
18793683-0	2008	Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	95-98
18793683-1	2008	The effect of diazepam, a benzodiazepine derivative, on the post-traumatic hyperactivity of excitatory synaptic transmission was examined in rat hippocampal CA1 area.	Diazepam	14-22	carbonic anhydrase 1	Rattus norvegicus	157-160
18793683-12	2008	These results suggest that administration of diazepam at early post-traumatic period prevents the FPI-induced delayed enhancement of excitatory synaptic transmission in rat hippocampal CA1 neurons.	Diazepam	45-53	carbonic anhydrase 1	Rattus norvegicus	185-188
19066419-2	2008	In view of the withdrawal anxiety associated with repeated diazepam intake, the present study concerns the efficacy of 5-HT2C receptors in rats treated with diazepam.	Diazepam	157-165	5-hydroxytryptamine receptor 2C	Rattus norvegicus	119-125
18481302-1	2008	Acyl-CoA-binding protein (ACBP), also known as the diazepam-binding inhibitor (DBI), has been identified in diverse species and is evolutionarily conserved in plants and animals.	Diazepam	51-59	acyl-CoA binding protein	Bombyx mori	26-30
18499303-15	2008	Collectively, our findings suggest that the effects on anxiety elicited by pentylenetetrazol and diazepam can be counteracted or potentiated in the presence of N/OFQ and nocistatin.	Diazepam	97-105	prepronociceptin	Mus musculus	160-165
18455367-7	2008	Although several antiepileptic drugs, including barbiturates, diazepam, chloralhydrate, and valproic acid, have been shown to inhibit GLUT1 function, the present study demonstrated no inhibitory effect of zonisamide on GLUT1-mediated glucose transport.	Diazepam	62-70	solute carrier family 2 member 1	Homo sapiens	134-139
18418736-6	2008	We also found that SLC38A1 is highly up regulated in the cortex from rats treated with diazepam and that SLC38A2 is significantly down regulated in the same tissue.	Diazepam	87-95	solute carrier family 38, member 1	Rattus norvegicus	19-26
18190907-3	2008	The aim of this study was to examine the effects of some benzodiazepines (bromazepam, chlordiazepoxide, diazepam and flurazepam) able to bind to P-glycoprotein in proteoliposomes on its transport function and ATPase activity in the human cancer cell line, KB-V1.	Diazepam	104-112	ATP binding cassette subfamily B member 1	Homo sapiens	145-159
18255166-8	2008	In FS rats, diazepam did not have effect on GABA release but reduced pain scores and overexpression of c-Fos whereas flumazenil (0.1 mg/kg, i.p.	Diazepam	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-108
18194441-1	2008	Horizontal optokinetic stimulation of rabbit retina in vivo evokes increased expression of acyl coenzyme A-binding protein (ACBP), also known as "diazepam binding inhibitor," from retinal Muller cells.	Diazepam	146-154	acyl-CoA-binding protein	Oryctolagus cuniculus	91-122
18194441-1	2008	Horizontal optokinetic stimulation of rabbit retina in vivo evokes increased expression of acyl coenzyme A-binding protein (ACBP), also known as "diazepam binding inhibitor," from retinal Muller cells.	Diazepam	146-154	acyl-CoA-binding protein	Oryctolagus cuniculus	124-128
18190907-9	2008	Bromazepam, chlordiazepoxide and diazepam behaved as activators of the P-glycoprotein ATPase activity, suggesting a role as transported substrates and did not interfere in the daunorubicin transport.	Diazepam	33-41	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
18190907-9	2008	Bromazepam, chlordiazepoxide and diazepam behaved as activators of the P-glycoprotein ATPase activity, suggesting a role as transported substrates and did not interfere in the daunorubicin transport.	Diazepam	33-41	dynein axonemal heavy chain 8	Homo sapiens	86-92
17805947-4	2008	On the other hand, the docking of diazepam to alpha1/gamma2 interface revealed five multi-member conformational clusters in the binding site and model 1 seemed to represent the correct orientation of diazepam in the binding site.	Diazepam	34-42	adrenoceptor alpha 1D	Homo sapiens	46-59
18239283-6	2008	Like flavonoids, diazepam inhibited the release of vascular endothelial growth factor (VEGF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) into supernatants of cultured in the SNU-C4 and MDA-MB-231 cells.	Diazepam	17-25	vascular endothelial growth factor A	Homo sapiens	51-85
18239283-6	2008	Like flavonoids, diazepam inhibited the release of vascular endothelial growth factor (VEGF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) into supernatants of cultured in the SNU-C4 and MDA-MB-231 cells.	Diazepam	17-25	vascular endothelial growth factor A	Homo sapiens	87-91
18239283-6	2008	Like flavonoids, diazepam inhibited the release of vascular endothelial growth factor (VEGF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) into supernatants of cultured in the SNU-C4 and MDA-MB-231 cells.	Diazepam	17-25	colony stimulating factor 2	Homo sapiens	97-145
18239283-6	2008	Like flavonoids, diazepam inhibited the release of vascular endothelial growth factor (VEGF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) into supernatants of cultured in the SNU-C4 and MDA-MB-231 cells.	Diazepam	17-25	colony stimulating factor 2	Homo sapiens	147-153
17974564-3	2008	Here we have used mutagenesis, radioligand binding, voltage clamp electrophysiology, and homology modeling to probe the role of the F-loop residues Asp(192)-Arg(197) in the GABA(A) receptor gamma(2) subunit in diazepam potentiation of the GABA response.	Diazepam	210-218	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	173-198
17805947-4	2008	On the other hand, the docking of diazepam to alpha1/gamma2 interface revealed five multi-member conformational clusters in the binding site and model 1 seemed to represent the correct orientation of diazepam in the binding site.	Diazepam	200-208	adrenoceptor alpha 1D	Homo sapiens	46-59
20641566-18	2004	The specific binding site II on HSA is located in a hydrophobic cavity of 8-10 A in diameter and has been a preferential binding site for many ligands, such as fenbufen, diazepam, and piroxicam, in drug designs (5).	Diazepam	170-178	albumin	Homo sapiens	32-35
18076219-19	2008	Dosage adjustments may be required for drugs that are substrates of CYP3A4 (e.g. ciclosporin, triazolam) and CYP2C19 enzymes (e.g. diazepam, phenytoin) when administered with armodafinil.	Diazepam	131-139	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74
18076219-19	2008	Dosage adjustments may be required for drugs that are substrates of CYP3A4 (e.g. ciclosporin, triazolam) and CYP2C19 enzymes (e.g. diazepam, phenytoin) when administered with armodafinil.	Diazepam	131-139	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	109-116
18175099-8	2008	CYP3A4 is important in the biotransformation of both midazolam and diazepam.	Diazepam	67-75	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
18175099-9	2008	CYP2C19 is important in the biotransformation of diazepam.	Diazepam	49-57	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
18175099-13	2008	Being metabolized by CYP enzymes, midazolam and diazepam have many clinically significant interactions with inhibitors and inducers of CYP3A4 and 2C19.	Diazepam	48-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	135-150
18240651-1	2007	As a help of elucidate of the pathogenesis of alcohol dependence, we investigated the relationship between the genetic variants of the diazepam biding inhibitor (DBI) gene polymorphism and alcoholism.	Diazepam	135-143	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	162-165
18277461-0	2007	Tolerance in the anxiolytic profile following repeated administration of diazepam but not buspirone is associated with a decrease in the responsiveness of postsynaptic 5-HT-1A receptors.	Diazepam	73-81	5-hydroxytryptamine receptor 1A	Rattus norvegicus	168-175
18277461-5	2007	The results suggest that postsynaptic 5-HT-1A receptor-dependent responses were attenuated following long-term administration of diazepam but not buspirone.	Diazepam	129-137	5-hydroxytryptamine receptor 1A	Rattus norvegicus	38-45
18277461-6	2007	Role of 5-HT-1A receptors in the development of tolerance to the anxiolytic effects of diazepam but not buspirone is discussed.	Diazepam	87-95	5-hydroxytryptamine receptor 1A	Rattus norvegicus	8-15
17669374-0	2007	Brainstem areas activated by diazepam withdrawal as measured by Fos-protein immunoreactivity in rats.	Diazepam	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-67
17561806-4	2007	Immunohistochemical studies revealed that TSPO is localized in mitochondria, and its endogenous ligand, the polypeptide diazepam-binding inhibitor, in the cytosol.	Diazepam	120-128	translocator protein	Homo sapiens	42-46
17601555-7	2007	Co-administration of rolipram or diazepam with morphine during the pre-treatment period significantly reduces the signs of withdrawal symptoms, the enhancement of NA turnover, the increase in cyclic AMP and the Fos expression.	Diazepam	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	211-214
17442049-3	2007	Basal level of both hippocampal and cerebellar [(3)H]muscimol binding was lower and sensitivity to the hypothermic effects of diazepam and pentobarbital was increased in CB1-/- mice.	Diazepam	126-134	cannabinoid receptor 1 (brain)	Mus musculus	170-173
17635335-3	2007	The pharmacokinetics of diazepam, etizolam, quazepam and desmethylclobazam have been shown to be affected by CYP2C19 polymorphism.	Diazepam	24-32	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	109-116
17631921-8	2007	The effects of specific TSPO ligands PK 11195 and Ro5-4864 were reproduced by diazepam, which binds with high affinity both TSPO and central benzodiazepine receptors, but not by clonazepam, which binds exclusively to GABA receptor, and other amphiphilic substances such as DIDS and propranolol.	Diazepam	78-86	translocator protein	Homo sapiens	24-28
17631921-8	2007	The effects of specific TSPO ligands PK 11195 and Ro5-4864 were reproduced by diazepam, which binds with high affinity both TSPO and central benzodiazepine receptors, but not by clonazepam, which binds exclusively to GABA receptor, and other amphiphilic substances such as DIDS and propranolol.	Diazepam	78-86	translocator protein	Homo sapiens	124-128
17631921-8	2007	The effects of specific TSPO ligands PK 11195 and Ro5-4864 were reproduced by diazepam, which binds with high affinity both TSPO and central benzodiazepine receptors, but not by clonazepam, which binds exclusively to GABA receptor, and other amphiphilic substances such as DIDS and propranolol.	Diazepam	78-86	GABA type A receptor-associated protein	Homo sapiens	217-230
29788670-3	2007	PPIs affect the pharmacokinetics of other substrates of CYP2C19, such as warfarin and diazepam.	Diazepam	86-94	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	56-63
17092983-1	2007	Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABA(A) receptors containing either an alpha1, alpha2, alpha3 or alpha5 subunit.	Diazepam	39-47	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	154-178
17164814-5	2007	Furthermore, GAT1(-/-) mice exhibited measurable insensitivity to selected antidepressants and anxiolytics such as fluoxetine, amitriptyline, buspirone, diazepam, and tiagabine in the tail-suspension test and/or the EPM test.	Diazepam	153-161	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	13-17
17087982-2	2007	Most 1,4-BZs like diazepam recognize all GABA(A)/BZ receptors containing the alpha1-3 or alpha5 together with any beta and the gamma2 subunit.	Diazepam	18-26	adrenoceptor alpha 1D	Homo sapiens	77-85
17377772-3	2007	Human embryonic kidney (HEK 293) cells stably expressing recombinant alpha1beta2gamma2s GABA(A) receptors were exposed for 72 h to a high concentration of diazepam (50 microM) in the absence or presence of other drugs.	Diazepam	155-163	adrenoceptor alpha 1D	Homo sapiens	69-86
16936706-5	2007	These KCC2-deficient mice show decreased sensitivity to diazepam-induced sedation and motor impairment consistent with the reported role for KCC2 in fast hyperpolarizing inhibition.	Diazepam	56-64	solute carrier family 12, member 5	Mus musculus	6-10
17284003-3	2007	Diazepam is such a drug that undergoes metabolism by CYP3A4 with sigmoidal dependence.	Diazepam	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	53-59
16257421-9	2006	Particularly, our findings might be due to a direct effect of diazepam on PBRs present on macrophages and tumor cells, or could still be mediated by PBR stimulation within the hypothalamus-pituitary-adrenal (HPA) axis.	Diazepam	62-70	resistance to Paracoccidioides brasiliensis	Mus musculus	74-77
17375979-8	2007	CYP2C19 contributes to the metabolism of diazepam and phenytoin, the latter drug also representing a substrate of CYP2C9, with its predominant variants being defined as *2 and *3.	Diazepam	41-49	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
17375979-8	2007	CYP2C19 contributes to the metabolism of diazepam and phenytoin, the latter drug also representing a substrate of CYP2C9, with its predominant variants being defined as *2 and *3.	Diazepam	41-49	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	114-120
17320309-5	2007	Recent findings indicate that diazepam exerts an inhibitory activity on different isoforms of the enzyme cyclic nucleotide phosphodiesterase, which can be found in the heart muscle and also show that diazepam potentate the positive inotropic effect of both noradrenaline and adrenaline, which subsequently leads to increase in myocardial contractility.	Diazepam	30-38	phosphodiesterase 3B	Homo sapiens	105-140
17320309-5	2007	Recent findings indicate that diazepam exerts an inhibitory activity on different isoforms of the enzyme cyclic nucleotide phosphodiesterase, which can be found in the heart muscle and also show that diazepam potentate the positive inotropic effect of both noradrenaline and adrenaline, which subsequently leads to increase in myocardial contractility.	Diazepam	200-208	phosphodiesterase 3B	Homo sapiens	105-140
16844276-12	2006	Rofecoxib (1 mg/kg) or nimesulide (1 mg/kg) also enhanced the sub-protective effect of diazepam or muscimol showing GABAergic modulation of COX-2 inhibitors.	Diazepam	87-95	cytochrome c oxidase II, mitochondrial	Mus musculus	140-145
17027961-5	2006	They also show that diazepam and Ro5-4864 (peripheral-type benzodiazepine receptor agonists) but not clonazepam (a molecule with low affinity for the peripheral-type benzodiazepine receptor) decreased the percentage of tumor cells in G0-G1 phases and increased that of cells in S-G2-M phases.	Diazepam	20-28	translocator protein	Mus musculus	43-82
17109943-2	2006	In previous experiments, overexpression of enkephalin in the amygdala enhanced the anxiolytic actions of the benzodiazepine agonist diazepam in the elevated plus maze.	Diazepam	132-140	proenkephalin	Rattus norvegicus	43-53
16835366-9	2006	In the CA1 area, the diazepam-sensitive component of tonic inhibition also involved activation of alpha5-GABA(A)Rs and slow phasic and tonic signals shared overlapping pools of receptors.	Diazepam	21-29	carbonic anhydrase 1	Mus musculus	7-10
16774749-7	2006	The cleavage of caspase-8 and Bid increased at 0 h, cytosolic fraction of cytochrome c and Smac/DIABLO increased by 2 h, cleavage of caspase-9 was detected by 4 h, TUNEL-positive neurons appeared at 8 h and reached a maximum at 24 h following administration of diazepam in the ipsilateral CA3 subfield of hippocampus.	Diazepam	261-269	caspase 9	Rattus norvegicus	133-142
16337685-7	2006	Putative endogenous ligands for PBR include protoporphyrin IX, diazepam binding inhibitor (DBI), triakontatetraneuropeptide (TTN), and phospholipase A2 (PLA2).	Diazepam	63-71	translocator protein	Homo sapiens	32-35
17301177-5	2007	Consistent with previous results, sensitivity to diazepam was reduced in electrophysiological and behavioral analyses of PRIP-DKO mice, suggesting an alteration of gamma2 subunit-containing GABA(A) receptors.	Diazepam	49-57	phospholipase C-like 1	Mus musculus	121-125
17301177-6	2007	The surface numbers of diazepam binding sites (alpha/gamma2 subunits) assessed by [3H]flumazenil binding were reduced in the PRIP-DKO mice as compared with those of wild-type mice, whereas the cell surface GABA binding sites (alpha/beta subunits, assessed by [3H]muscimol binding) were increased in PRIP-DKO mice.	Diazepam	23-31	phospholipase C-like 1	Mus musculus	125-129
16881070-9	2006	Increased acute sensitivity to ethanol and diazepam, which was previously reported, was confirmed in PKCepsilon null mice.	Diazepam	43-51	protein kinase C, epsilon	Mus musculus	101-111
16884554-3	2006	METHOD: Amyloid precursor protein concentrations were assessed by semi-quantitative Western-immunoblot in brains of rats following intraperitoneal treatment with diazepam and midazolam.	Diazepam	162-170	amyloid beta precursor protein	Rattus norvegicus	8-33
16884554-5	2006	CONCLUSION: Both diazepam and midazolam are considered to be relatively safe with respect to amyloid precursor protein metabolism.	Diazepam	17-25	amyloid beta precursor protein	Rattus norvegicus	93-118
16438989-2	2006	This effect was attributed to an action of diazepam on the peripheral-type benzodiazepine receptor (PBR) present in the adrenal and/or immune/inflammatory cells.	Diazepam	43-51	translocator protein	Rattus norvegicus	59-98
16438989-2	2006	This effect was attributed to an action of diazepam on the peripheral-type benzodiazepine receptor (PBR) present in the adrenal and/or immune/inflammatory cells.	Diazepam	43-51	translocator protein	Rattus norvegicus	100-103
16438989-7	2006	Most probably, these effects reflect a direct action of diazepam on PBR present in the endothelium of the microvascular ambient and/or on immune/inflammatory cells.	Diazepam	56-64	translocator protein	Rattus norvegicus	68-71
16554486-7	2006	Unexpectedly, we found that the benzodiazepines flunitrazepam and diazepam enhanced extrasynaptic inhibition mediated by delta subunit-containing GABARs in Gabra6(100Q/100Q) rats.	Diazepam	66-74	gamma-aminobutyric acid type A receptor subunit alpha6	Rattus norvegicus	156-162
16537521-2	2006	Behaviorally, socially isolated (SI) mice are resistant to the sedative effects of the positive allosteric GABA(A)-R modulators diazepam (DZP) and zolpidem.	Diazepam	128-136	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	107-116
16537521-2	2006	Behaviorally, socially isolated (SI) mice are resistant to the sedative effects of the positive allosteric GABA(A)-R modulators diazepam (DZP) and zolpidem.	Diazepam	138-141	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	107-116
16684660-0	2006	On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.	Diazepam	75-83	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	101-106
16358339-8	2006	In addition, the anticonvulsant diazepam (intraperitoneal) significantly reduced cell death (P < 0.001) and seizure duration (P < 0.001) induced by AMPA with IL-1, and a significant correlation was found between seizure duration and cell death volume.	Diazepam	32-40	interleukin 1 alpha	Homo sapiens	164-168
16368818-0	2006	Cyclooxygenase-1 inhibition shortens the duration of diazepam-induced loss of righting reflex in mice.	Diazepam	53-61	prostaglandin-endoperoxide synthase 1	Mus musculus	0-16
16714778-1	2006	The in vitro effect of digoxin, verapamil, propranolol, carbamazepine, diazepam and promethazine were investigated on the ecto-ATPase activity of synaptosomal plasma membranes from the rat brain.	Diazepam	71-79	CEA cell adhesion molecule 1	Rattus norvegicus	122-133
16842193-1	2006	The peripheral benzodiazepine receptor (PBR) initially characterised as a high affinity binding site for diazepam, is densely distributed in most peripheral organs whilst only moderately expressed in the healthy brain.	Diazepam	105-113	translocator protein	Homo sapiens	4-38
16842193-1	2006	The peripheral benzodiazepine receptor (PBR) initially characterised as a high affinity binding site for diazepam, is densely distributed in most peripheral organs whilst only moderately expressed in the healthy brain.	Diazepam	105-113	translocator protein	Homo sapiens	40-43
16684660-2	2006	In rats, diazepam and oxazepam induced CYP2B, and were as effective as phenobarbital despite lacking phenobarbital"s tumor-promoting effect in rats.	Diazepam	9-17	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	39-44
16684660-3	2006	In mice, diazepam and oxazepam induced both CYP2B and CYP4A at dietary doses associated with liver tumor formation.	Diazepam	9-17	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	44-49
16684660-3	2006	In mice, diazepam and oxazepam induced both CYP2B and CYP4A at dietary doses associated with liver tumor formation.	Diazepam	9-17	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	54-59
16684660-4	2006	It remains to be determined why diazepam and oxazepam induce CYP4A in mice but not rats and whether this difference accounts for the apparent species difference in the tumor-promoting activity of diazepam and oxazepam.	Diazepam	32-40	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	61-66
16257728-6	2005	The equilibrium geometry parameters of CTMS obtained in this work at the MP2/DZP+diff level are closer to the experimental values than previous predictions.	Diazepam	77-80	tryptase pseudogene 1	Homo sapiens	73-76
16307177-1	2006	CYP2C19 is a clinically important enzyme involved in the metabolism of therapeutic drugs such as (S)-mephenytoin, omeprazole, proguanil, and diazepam.	Diazepam	141-149	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
16771600-12	2006	Other drugs metabolized by CYP2C19 are diazepam and omeprazole.	Diazepam	39-47	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	27-34
16338280-0	2005	CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia.	Diazepam	25-33	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
16338280-11	2005	CONCLUSION: We found that the CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia and that the slow-emergence group possesses lower levels of CYP3A4 mRNA than are found in the rapid-emergence group.	Diazepam	55-63	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	30-37
16081673-0	2005	Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats.	Diazepam	40-48	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	14-20
16081673-6	2005	Comparing the expression levels of the CYP2D subfamily in liver microsomes from various strains of rats using anti-CYP2D2 antibody, we found that there was a band of protein that was consistent with the phenotype of diazepam p-hydroxylation.	Diazepam	216-224	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	115-121
16081673-7	2005	N-terminal amino acid sequences of the specific protein exactly corresponded to those of CYP2D3, indicating that CYP2D3 might be involved in diazepam p-hydroxylation.	Diazepam	141-149	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	89-95
16081673-7	2005	N-terminal amino acid sequences of the specific protein exactly corresponded to those of CYP2D3, indicating that CYP2D3 might be involved in diazepam p-hydroxylation.	Diazepam	141-149	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	113-119
16081673-10	2005	On the other hand, diazepam p-hydroxylation was catalyzed by CYP2D3.	Diazepam	19-27	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	61-67
16081673-11	2005	CYP2D4 had high activity toward diazepam N-desmethylation, but not p-hydroxylation.	Diazepam	32-40	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	0-6
16081673-12	2005	In conclusion, the polymorphic expression of CYP2D3 caused the inter- or intrastrain differences in diazepam p-hydroxylation among rat strains or individuals.	Diazepam	100-108	cytochrome P450, family 2, subfamily d, polypeptide 3	Rattus norvegicus	45-51
16168444-6	2006	Prior administration of GABA(A) receptor agonists muscimol (25 ng/rat, icv) and diazepam (0.5 mg/kg, ip) at subeffective doses significantly potentiated the hyperphagic effect of orexin-A (30 nM/rat, icv).	Diazepam	80-88	hypocretin neuropeptide precursor	Rattus norvegicus	179-187
20641363-3	2004	CBRs have been studied in vivo by positron emission tomography (PET) and single photon emission computed tomography, and the existence of a specific benzodiazepine receptor linked to the gamma-aminobutyric acid (GABA) receptor/chloride ionophore has been shown by use of diazepam (4).	Diazepam	271-279	GABA type A receptor-associated protein	Homo sapiens	187-226
16339017-9	2005	However, in alpha1beta2gamma2S transfections in which stoichiometry was not fixed, GABARAP-EGFP altered desensitization, deactivation, and diazepam potentiation of GABA-mediated currents.	Diazepam	139-147	GABA type A receptor-associated protein	Homo sapiens	83-90
16184188-1	2005	Classical benzodiazepines (BZs), such as diazepam, bind to GABAA receptors containing alpha1, alpha2, alpha3 or alpha5 subunits that are therefore described as diazepam-sensitive (DS) receptors.	Diazepam	41-49	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	94-118
16184188-1	2005	Classical benzodiazepines (BZs), such as diazepam, bind to GABAA receptors containing alpha1, alpha2, alpha3 or alpha5 subunits that are therefore described as diazepam-sensitive (DS) receptors.	Diazepam	160-168	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	94-118
16048486-0	2005	The bioreactor with CYP3A4- and glutamine synthetase-introduced HepG2 cells: treatment of hepatic failure dog with diazepam overdosage.	Diazepam	115-123	cytochrome P450 3A12	Canis lupus familiaris	20-26
16085363-6	2005	Catalase activity was also determined after pretreatment with the anticonvulsant drug, diazepam, alone or injected before cocaine 90 mg/kg, and after seizures induced by a high dose of bupropion, a known inhibitor of NE and DA reuptake used for comparison.	Diazepam	87-95	catalase	Mus musculus	0-8
16141545-5	2005	In addition, the metabolic activities of diazepam, clotiazepam, and etizolam in human liver microsomes were inhibited by 2.5 microM ketoconazole, a CYP3A4 inhibitor, by 97.5%, 65.1%, and 83.5%, respectively, and the imipramine metabolism was not detected after the addition of 1 or 10 microM quinidine, a CYP2D6 inhibitor.	Diazepam	41-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	148-154
16141545-5	2005	In addition, the metabolic activities of diazepam, clotiazepam, and etizolam in human liver microsomes were inhibited by 2.5 microM ketoconazole, a CYP3A4 inhibitor, by 97.5%, 65.1%, and 83.5%, respectively, and the imipramine metabolism was not detected after the addition of 1 or 10 microM quinidine, a CYP2D6 inhibitor.	Diazepam	41-49	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	305-311
16125698-8	2005	Strong induction of Fos in the paraventricular nucleus was found in response to zolpidem, diazepam, and zopiclone, but not after L-838,417.	Diazepam	90-98	FBJ osteosarcoma oncogene	Mus musculus	20-23
16048486-2	2005	Its usefulness in a large-scale culture with a circulatory bioreactor in vitro and in dog models of ischemic hepatic failure with acute diazepam (DZP, a substrate of CYP3A4) overdosage was further examined.	Diazepam	146-149	cytochrome P450 3A12	Canis lupus familiaris	166-172
15341600-2	2004	Using mice, which carry a point mutation that renders specific subtypes of GABA A receptors diazepam insensitive, it was recently discovered that particular types of GABA A receptors are involved in specific, behaviorally relevant signaling pathways.	Diazepam	92-100	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	75-81
15912137-5	2005	Consistent with this prediction, diazepam increased the efficacy of the GABA(A) receptor partial agonist kojic amine in chick spinal cord neurons.	Diazepam	33-41	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	72-88
16168624-0	2005	Long-term effects of diazepam treatment of epileptic GABAA receptor beta3 subunit knockout mouse in early life.	Diazepam	21-29	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	68-73
16168624-4	2005	The EEG of control mice remained unaffected under all conditions, but the EEG of beta3 (-/-) injected with diazepam in week 1 was worsened, showing increased oscillatory activity at 5-6Hz, and more myoclonic jerks, particularly among males.	Diazepam	107-115	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	81-86
16168624-5	2005	For beta3 (-/-) injected with diazepam in week 2, the EEG was normalized in half the mice but worsened similarly to week 1 in the other half.	Diazepam	30-38	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	4-9
16168624-6	2005	Neonatal diazepam injection had a long-term normalizing effect on behavior of beta3 (-/-) mice injected in week 1, but diazepam treatment in week 2 did not affect the hyperactive and circling behavior characteristic of the beta3 knockout mouse.	Diazepam	9-17	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	78-83
16168624-7	2005	Diazepam treatment in postnatal week 2 significantly decreased anxiety in the adult beta3 group.	Diazepam	0-8	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	84-89
16168624-8	2005	Diazepam treatment in both postnatal weeks 1 and 2 improved the motor coordination of beta3 (-/-) on the rotarod, although performance of control mice injected with diazepam in postnatal week 2 was significantly impaired.	Diazepam	0-8	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	86-91
15976032-10	2005	Histochemical examination showed that activation of caspase-3 was accompanied by apoptotic cell death of granule cells that was induced by sensory deprivation or diazepam administration.	Diazepam	162-170	caspase 3	Mus musculus	52-61
16045030-7	2005	Diazepam inhibited the serum levels of ALT, AST, TNF-alpha and IL-1, and reduced levels of MDA, NO and NOS and increased levels of GR and SOD in the liver.	Diazepam	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	39-42
16045030-7	2005	Diazepam inhibited the serum levels of ALT, AST, TNF-alpha and IL-1, and reduced levels of MDA, NO and NOS and increased levels of GR and SOD in the liver.	Diazepam	0-8	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	44-47
16045030-7	2005	Diazepam inhibited the serum levels of ALT, AST, TNF-alpha and IL-1, and reduced levels of MDA, NO and NOS and increased levels of GR and SOD in the liver.	Diazepam	0-8	tumor necrosis factor	Mus musculus	49-58
16045030-7	2005	Diazepam inhibited the serum levels of ALT, AST, TNF-alpha and IL-1, and reduced levels of MDA, NO and NOS and increased levels of GR and SOD in the liver.	Diazepam	0-8	interleukin 1 complex	Mus musculus	63-67
16045030-9	2005	CONCLUSION: Treatment with diazepam may suppress the D-GalN/LPS-induced acute hepatic failure and modafinil may facilitate the acute hepatic failure.	Diazepam	27-35	galanin and GMAP prepropeptide	Mus musculus	55-59
15613639-4	2005	Whole-cell GABA receptor currents were moderately sensitive to GABAA and were modulated by diazepam.	Diazepam	91-99	GABA type A receptor-associated protein	Homo sapiens	11-24
15713338-8	2005	Furthermore, treatment with a combination of diazepam and atropine maintained IL-1beta levels at normal when administered at the onset of the seizures following soman exposure.	Diazepam	45-53	interleukin 1 beta	Rattus norvegicus	78-86
16059654-3	2005	Here, we attempted to enhance hypericin-induced photocytotoxicity and apoptosis by diazepam, a non-selective ligand of peripheral benzodiazepine receptors (PBR) which seem to play an important role in apoptosis regulation.	Diazepam	83-91	translocator protein	Homo sapiens	119-154
16059654-3	2005	Here, we attempted to enhance hypericin-induced photocytotoxicity and apoptosis by diazepam, a non-selective ligand of peripheral benzodiazepine receptors (PBR) which seem to play an important role in apoptosis regulation.	Diazepam	83-91	translocator protein	Homo sapiens	156-159
15304513-5	2004	Immunodepletion studies indicated that the His to Arg point mutation solely rendered those GABAA receptors totally insensitive to diazepam binding that contain two mutated alpha subunits in the receptor complex, whereas receptors containing one mutated and one heterologous alpha subunit not carrying the mutation remained sensitive to diazepam binding.	Diazepam	336-344	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	91-96
15304513-6	2004	This feature permitted a quantitative analysis of native GABAA receptors containing heterologous alpha subunits by comparing the diazepam-insensitive binding sites in mutant mouse lines containing one mutated alpha subunit with those present in mouse lines containing two different mutated alpha subunits.	Diazepam	129-137	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	57-62
15349957-7	2004	Solubilization of diazepam was greater with DSPE-PEG 2000 than DSPE-PEG 5000 simple micelles as determined by RP-HPLC.	Diazepam	18-26	progestagen associated endometrial protein	Homo sapiens	49-52
15349957-7	2004	Solubilization of diazepam was greater with DSPE-PEG 2000 than DSPE-PEG 5000 simple micelles as determined by RP-HPLC.	Diazepam	18-26	progestagen associated endometrial protein	Homo sapiens	68-71
15714225-0	2005	Stress-induced c-Fos expression is differentially modulated by dexamethasone, diazepam and imipramine.	Diazepam	78-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	15-20
15714225-12	2005	We conclude that dexamethasone, diazepam and imipramine differentially modulate stress-induced Fos expression.	Diazepam	32-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-98
15926867-1	2005	Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of GABA at GABA(A) receptors containing either an alpha1, -2, -3 or -5 subunit.	Diazepam	77-85	adrenoceptor alpha 1D	Homo sapiens	177-197
15924675-8	2005	The relative expressions of MMP-9 mRNA in the cells of the blank control group and those with diazepam at final concentrations of 0.1, 10 micromol/L were all time dependent, in another word, the expressions gradually increased over time.	Diazepam	94-102	matrix metallopeptidase 9	Homo sapiens	28-33
15924675-10	2005	In the blank control group and group with diazepam at final concentration of 0.1 micromol/L, the MMP-9 contents in supernatant showed a time dependent increase, with a significant difference between the two groups (P < 0.05).	Diazepam	42-50	matrix metallopeptidase 9	Homo sapiens	97-102
15319337-4	2004	However, the expression levels of cytochrome P450 CYP2D1, the reported enzyme for diazepam p-hydroxylation, did not cosegregate with the activity.	Diazepam	82-90	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	50-56
15319337-7	2004	In agreement with this, DA rat liver microsomes had a higher expression of CYP3A2, which is responsible for diazepam 3-hydroxylation and partly responsible for N-desmethylation.	Diazepam	108-116	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	75-81
15341600-2	2004	Using mice, which carry a point mutation that renders specific subtypes of GABA A receptors diazepam insensitive, it was recently discovered that particular types of GABA A receptors are involved in specific, behaviorally relevant signaling pathways.	Diazepam	92-100	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	166-172
15341600-6	2004	Based on the different responses to diazepam, we found that IPSCs in the lateral/basolateral amygdala were mediated by both alpha2- and alpha1-subunit-containing GABA A receptors whereas those in the central amygdala were mediated only by alpha2-subunit-containing GABA A receptors.	Diazepam	36-44	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	162-168
15341600-11	2004	Mice with specific diazepam-insensitive GABA A receptor subtypes therefore provide a novel tool to investigate GABA A receptor distribution and the organization of inhibitory circuits at a functional level.	Diazepam	19-27	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	111-117
15148255-0	2004	Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport.	Diazepam	67-75	thyrotropin releasing hormone	Homo sapiens	14-17
15354722-5	2004	Although epilepsy-like symptoms occurred at the first course of VIP therapy, these symptoms immediately improved by diazepam administration.	Diazepam	116-124	vasoactive intestinal peptide	Homo sapiens	64-67
15193532-4	2004	Post-ischemic diazepam reduces CA1 injury.	Diazepam	14-22	carbonic anhydrase 1	Homo sapiens	31-34
14726306-1	2004	Previous studies have demonstrated that gastric mucosa contained high levels of the polypeptide diazepam binding inhibitor, the endogenous ligand of the peripheral-type benzodiazepine receptor (PBR).	Diazepam	96-104	translocator protein	Rattus norvegicus	153-192
14726306-1	2004	Previous studies have demonstrated that gastric mucosa contained high levels of the polypeptide diazepam binding inhibitor, the endogenous ligand of the peripheral-type benzodiazepine receptor (PBR).	Diazepam	96-104	translocator protein	Rattus norvegicus	194-197
15148255-3	2004	This paper shows that nootropic drugs like piracetam (2-oxo 1 pyrrolidine acetamide) and levetiracetam and neuropeptides like TRH antagonise the inhibition of glucose transport by barbiturates, diazepam, melatonin and endogenous neuropeptide galanin in human erythrocytes in vitro.	Diazepam	194-202	thyrotropin releasing hormone	Homo sapiens	126-129
15148255-10	2004	Mapped on a 3D template of GLUT1, these homologies suggest that the site of diazepam and piracetam interaction is a pocket outside the central hydrophilic pore region.	Diazepam	76-84	solute carrier family 2 member 1	Homo sapiens	27-32
15081382-0	2004	MK-801 prevents the increased NMDA-NR1 and NR2B subunits mRNA expression observed in the hippocampus of rats tolerant to diazepam.	Diazepam	121-129	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	43-47
15007071-2	2004	Furthermore, the conductance of some native GABA(A) channels can be increased by diazepam or pentobarbital, which are effects not reported for expressed GABA(A) channels.	Diazepam	81-89	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	44-51
15007071-2	2004	Furthermore, the conductance of some native GABA(A) channels can be increased by diazepam or pentobarbital, which are effects not reported for expressed GABA(A) channels.	Diazepam	81-89	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	153-160
15007071-6	2004	In contrast, in cells expressing the same three subunits together with GABARAP, channel conductance could be significantly higher than 40 pS, and channel conductance was increased by diazepam and pentobarbital.	Diazepam	183-191	gamma-aminobutyric acid receptor associated protein	Mus musculus	71-78
15197128-8	2004	Median cumulative dose of diazepam (PRE: 20.0 vs POST: 10.0 mg; P < 0.05) decreased.	Diazepam	26-34	solute carrier family 35 member G1	Homo sapiens	49-53
15081382-5	2004	Our results demonstrate that the development of tolerance to the hypolocomotive effect of diazepam, along with the increased hippocampal synaptic plasticity and the associated over expression of the mRNA NR1 and NR2B N-methyl-D-aspartate receptor subunits, were blocked by previous MK-801 administration.	Diazepam	90-98	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	204-207
15081382-5	2004	Our results demonstrate that the development of tolerance to the hypolocomotive effect of diazepam, along with the increased hippocampal synaptic plasticity and the associated over expression of the mRNA NR1 and NR2B N-methyl-D-aspartate receptor subunits, were blocked by previous MK-801 administration.	Diazepam	90-98	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	212-216
15067703-7	2004	We examined the expression levels of CYP2D1, which was reported to catalyze diazepam p-hydroxylation in Wistar rats to find no differences in the expression levels of CYP2D1 between EM and PM rats.	Diazepam	76-84	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	37-43
15128862-11	2004	Here, we added diazepam early after oxygen-glucose deprivation and prevented the downregulation of KCC2 and the accumulation of [Cl-]i. Consequently, both GABA(A) responses and synaptic transmission within the hippocampus were restored.	Diazepam	15-23	solute carrier family 12 member 5	Rattus norvegicus	99-103
15220017-1	2004	BACKGROUND: It has been previously demonstrated that diazepam inhibits the cyclic nucleotide phosphodiesterase type 4 isozyme (PDE4).	Diazepam	53-61	phosphodiesterase 4A	Homo sapiens	127-131
15220017-11	2004	CONCLUSION: In this preliminary study, diazepam increased cAMP plasma levels in anesthetized patients, presumably through inhibition of PDE4 activity.	Diazepam	39-47	phosphodiesterase 4A	Homo sapiens	136-140
15067703-12	2004	The current results infer polymorphic expression of new diazepam p-hydroxylating enzyme with lower K(m) than CYP2D1 in EM Wistar rats.	Diazepam	56-64	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	109-115
15048936-4	2004	Termination of seizures by lorazepam was more effective than diazepam in both strains, largely restricting neuronal loss to the CA3 sector.	Diazepam	61-69	carbonic anhydrase 3	Mus musculus	128-131
14749435-6	2004	At all of the ages, selective stimulation of PBR by diazepam in the presence of flumazenil prolonged GABA(A) mIPSCs in a PK11195- and finasteride-sensitive manner.	Diazepam	52-60	translocator protein	Rattus norvegicus	45-48
15009662-4	2004	In wild-type animals, diazepam reduced the expression levels of the alpha subunit of the calcium/calmodulin-dependent protein kinase II, as well as brain-derived neurotrophic factor, MAP kinase phosphatase, transcription factor GIF, c-fos and nerve growth factor induced gene-A.	Diazepam	22-30	brain derived neurotrophic factor	Mus musculus	148-181
15009662-4	2004	In wild-type animals, diazepam reduced the expression levels of the alpha subunit of the calcium/calmodulin-dependent protein kinase II, as well as brain-derived neurotrophic factor, MAP kinase phosphatase, transcription factor GIF, c-fos and nerve growth factor induced gene-A.	Diazepam	22-30	FBJ osteosarcoma oncogene	Mus musculus	233-238
15009662-4	2004	In wild-type animals, diazepam reduced the expression levels of the alpha subunit of the calcium/calmodulin-dependent protein kinase II, as well as brain-derived neurotrophic factor, MAP kinase phosphatase, transcription factor GIF, c-fos and nerve growth factor induced gene-A.	Diazepam	22-30	nerve growth factor	Mus musculus	243-262
14723961-1	2004	Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed.	Diazepam	112-120	translocator protein	Rattus norvegicus	10-44
14723961-1	2004	Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed.	Diazepam	112-120	translocator protein	Rattus norvegicus	46-49
15072265-5	2004	Diazepam-insensitive [3H]Ro 15-4513 binding was decreased by 89% in accordance with very low amount of alpha6 subunit mRNA present.	Diazepam	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	103-109
14660012-2	2003	Exposure (48 and/or 96 h) of human embryonic kidney (HEK 293) cells stably expressing recombinant alpha1beta2gamma2s GABA(A) receptors for gamma-aminobutyric (GABA, 1 mM) and muscimol (100 microM), but not for diazepam (1 microM), enhanced the maximum number (B(max)) of [3H]flunitrazepam binding sites without affecting their affinity (K(d)).	Diazepam	210-218	adrenoceptor alpha 1D	Homo sapiens	98-115
15111236-3	2004	The AT1 subtype receptor is involved because pretreatment with losartan, an AT1 antagonist, prevents Ang II, diazepam, and ethanol impairment of LTP as well as their effects on behavior.	Diazepam	109-117	angiotensin II receptor, type 1a	Rattus norvegicus	4-7
15111236-3	2004	The AT1 subtype receptor is involved because pretreatment with losartan, an AT1 antagonist, prevents Ang II, diazepam, and ethanol impairment of LTP as well as their effects on behavior.	Diazepam	109-117	angiotensin II receptor, type 1a	Rattus norvegicus	76-79
14643840-5	2003	Prior administration of diazepam and muscimol that promote the function of GABA(A) receptors reversed the anxiogenic response and decreased food intake elicited by alpha-MSH.	Diazepam	24-32	proopiomelanocortin	Rattus norvegicus	164-173
12876104-5	2003	Two independent predictors of relapse were identified by Cox regression analysis: use of more than 10 mg diazepam equivalent (RR = 2.4 [1.2 - 4.7]) and poor general health perception (RR = 0.98 [0.97 - 0.99]).	Diazepam	105-113	cytochrome c oxidase subunit 8A	Homo sapiens	57-60
14597328-2	2003	When expressed in Xenopus oocytes, the gamma2 subunit R43Q mutation abolished current enhancement by the benzodiazepine, diazepam, and the gamma2 subunit K289M mutation decreased current amplitudes.	Diazepam	121-129	tryptophanyl-tRNA synthetase 1	Homo sapiens	39-45
12946602-0	2003	NMDA-NR1 and -NR2B subunits mRNA expression in the hippocampus of rats tolerant to Diazepam.	Diazepam	83-91	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	5-8
12946602-0	2003	NMDA-NR1 and -NR2B subunits mRNA expression in the hippocampus of rats tolerant to Diazepam.	Diazepam	83-91	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	14-18
12946602-4	2003	The results of the present investigation show that the development of tolerance to hypolocomotor action of DZ (5 mg/kg/day) for 4 days results in a significant increase in the hybridization signals for mRNA for N-methyl-D-aspartate (NMDA) glutamatergic receptor NR1 and NR2B subunits in the hippocampal dentate gyrus.	Diazepam	107-109	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	262-265
12920172-3	2003	CYP2B11 and CYP3A12 effectively catalyzed the N1-demethylation and C3-hydroxylation of diazepam (and its derivatives), whereas CYP3A12 and CYP2D15 catalyzed exclusively the N- and O-demethylation, respectively, of dextromethorphan.	Diazepam	87-95	cytochrome P450 2B11	Canis lupus familiaris	0-7
12920172-3	2003	CYP2B11 and CYP3A12 effectively catalyzed the N1-demethylation and C3-hydroxylation of diazepam (and its derivatives), whereas CYP3A12 and CYP2D15 catalyzed exclusively the N- and O-demethylation, respectively, of dextromethorphan.	Diazepam	87-95	cytochrome P450 3A12	Canis lupus familiaris	12-19
12920172-3	2003	CYP2B11 and CYP3A12 effectively catalyzed the N1-demethylation and C3-hydroxylation of diazepam (and its derivatives), whereas CYP3A12 and CYP2D15 catalyzed exclusively the N- and O-demethylation, respectively, of dextromethorphan.	Diazepam	87-95	cytochrome P450 3A12	Canis lupus familiaris	127-134
12920172-3	2003	CYP2B11 and CYP3A12 effectively catalyzed the N1-demethylation and C3-hydroxylation of diazepam (and its derivatives), whereas CYP3A12 and CYP2D15 catalyzed exclusively the N- and O-demethylation, respectively, of dextromethorphan.	Diazepam	87-95	cytochrome P450 2D15	Canis lupus familiaris	139-146
14550784-0	2003	Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.	Diazepam	66-74	carbonic anhydrase 1	Rattus norvegicus	78-81
14659475-5	2003	Specifically, we demonstrate that (1) psychogenic stressors influence the in vivo release of CRH at the central nucleus of the amygdala (CeA); (2) although CRH changes within the CeA are exquisitely sensitive to stressors, they are also elicited by positive stimuli; and (3) while treatment with diazepam attenuates behavioral signs of anxiety, the CRH release associated with a stressor is unaffected by the treatment.	Diazepam	296-304	corticotropin releasing hormone	Homo sapiens	93-96
14659475-5	2003	Specifically, we demonstrate that (1) psychogenic stressors influence the in vivo release of CRH at the central nucleus of the amygdala (CeA); (2) although CRH changes within the CeA are exquisitely sensitive to stressors, they are also elicited by positive stimuli; and (3) while treatment with diazepam attenuates behavioral signs of anxiety, the CRH release associated with a stressor is unaffected by the treatment.	Diazepam	296-304	CEA cell adhesion molecule 3	Homo sapiens	179-182
12946602-4	2003	The results of the present investigation show that the development of tolerance to hypolocomotor action of DZ (5 mg/kg/day) for 4 days results in a significant increase in the hybridization signals for mRNA for N-methyl-D-aspartate (NMDA) glutamatergic receptor NR1 and NR2B subunits in the hippocampal dentate gyrus.	Diazepam	107-109	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	270-274
12708941-13	2003	Diazepam is one example of a drug that is extensively metabolized by CYP2C19 and could potentially influence phenytoin elimination by acting as an alternate substrate for this isoenzyme.	Diazepam	0-8	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	69-76
12869636-1	2003	CYP2C19 is an important human drug-metabolizing enzyme that metabolizes a number of clinically used drugs including the antiulcer drug omeprazole, the anxiolytic drug diazepam, the beta-blocker propranolol, the antimalarial drug proguanil, certain antidepressants and barbiturates, and the prototype substrate S-mephenytoin.	Diazepam	167-175	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
12931769-12	2003	The eta2 value of 0.124 suggested a moderate effect favoring the diazepam treatment.	Diazepam	65-73	DNA polymerase iota	Homo sapiens	4-8
12931769-14	2003	However, the eta2 value of 0.24 for treatment effect (diazepam versus no diazepam) suggested a meaningful difference between groups.	Diazepam	54-62	DNA polymerase iota	Homo sapiens	13-17
12931769-14	2003	However, the eta2 value of 0.24 for treatment effect (diazepam versus no diazepam) suggested a meaningful difference between groups.	Diazepam	73-81	DNA polymerase iota	Homo sapiens	13-17
12717139-5	2003	In the presence or absence of diazepam or midazolam, cells were stimulated by corticotropin-releasing hormone (CRH) or forskolin.	Diazepam	30-38	corticotropin releasing hormone	Mus musculus	78-109
12717139-8	2003	RESULTS: Diazepam and midazolam dose-dependently increased the proopiomelanocortin gene expression induced by CRH or forskolin.	Diazepam	9-17	pro-opiomelanocortin-alpha	Mus musculus	63-82
12717139-8	2003	RESULTS: Diazepam and midazolam dose-dependently increased the proopiomelanocortin gene expression induced by CRH or forskolin.	Diazepam	9-17	corticotropin releasing hormone	Mus musculus	110-113
12717139-10	2003	Cyclic AMP efflux induced by CRH or forskolin was also enhanced by diazepam and midazolam.	Diazepam	67-75	corticotropin releasing hormone	Mus musculus	29-32
12890762-3	2003	Diazepam (DZ) or vehicle solution was infused daily before and/or during 4 d of MD in GAD65 knock-out mice.	Diazepam	0-8	glutamic acid decarboxylase 2	Mus musculus	86-91
12804891-1	2003	Human serum albumin (HSA) was immobilized on the surface of colloidal Au and exposed to diazepam.	Diazepam	88-96	albumin	Homo sapiens	6-25
12804891-6	2003	Cyclic voltammetry and electrochemical impedance techniques were used to investigate the immobilization of HSA and the interaction between HSA and diazepam.	Diazepam	147-155	albumin	Homo sapiens	139-142
12708941-16	2003	CONCLUSIONS: Phenytoin is a known inducer of drugs metabolized by CYP2C, CYP2D, and CYP3A, but its own metabolism may be altered by drugs influencing CYP2C9 or CYP2C19, such as diazepam.	Diazepam	177-185	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	150-156
12716027-0	2003	Tolerance to diazepam-induced motor impairment: a study with GABAA receptor alpha6 subunit knockout mice.	Diazepam	13-21	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	61-66
12729947-0	2003	Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.	Diazepam	92-100	5-hydroxytryptamine receptor 1A	Rattus norvegicus	119-125
12716027-0	2003	Tolerance to diazepam-induced motor impairment: a study with GABAA receptor alpha6 subunit knockout mice.	Diazepam	13-21	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	76-82
12716027-2	2003	The alpha6 -/- mice were more impaired by the initial challenge doses of diazepam (5 or 10 mg/kg) than their controls, but acquired partial tolerance by the second tests with the same doses 4-7 days later.	Diazepam	73-81	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	4-10
12711385-3	2003	Mouse and human PAP7 share an 85% amino acid identity and contain a conserved acyl-CoA-binding protein/diazepam binding inhibitor (ACBP/DBI) motif.	Diazepam	103-111	acyl-CoA binding domain containing 3	Homo sapiens	16-20
12691780-5	2003	Chronic anxiolytic treatment with the selective CCK-B (CCK(2)) receptor antagonist, Ci-988 (0.3 mg/kg/day ip) or diazepam (2 mg/kg/day ip), induced numerous effects throughout the central nervous system (CNS), with Ci-988 inducing significant changes in the density of dopamine D(2) receptors, and diazepam producing marked changes in both dopamine D(2) and CCK-B receptor binding density as well as preproCCK mRNA expression.	Diazepam	298-306	cholecystokinin B receptor	Rattus norvegicus	55-71
12639701-7	2003	Data were discussed in the light of peripheral benzodiazepine receptor site (PBR) activation within adrenal gland cells by diazepam, thereby increasing the serum levels of corticosterone and thus reducing CIPE.	Diazepam	123-131	translocator protein	Rattus norvegicus	77-80
12711385-3	2003	Mouse and human PAP7 share an 85% amino acid identity and contain a conserved acyl-CoA-binding protein/diazepam binding inhibitor (ACBP/DBI) motif.	Diazepam	103-111	diazepam binding inhibitor	Mus musculus	131-135
12650970-1	2003	Sardinian alcohol non-preferring (sNP) rats, selected for their low ethanol preference and consumption, carry a point mutation (R100Q) in the gene coding for GABA(A) receptor alpha(6) subunit, which becomes more sensitive to diazepam-evoked GABA currents.	Diazepam	225-233	gamma-aminobutyric acid type A receptor subunit alpha6	Rattus norvegicus	158-191
12464799-1	2002	CYP2C19 is a clinically important enzyme responsible for the metabolism of a number of therapeutic drugs, such as mephenytoin, omeprazole, diazepam, proguanil, propranolol and certain antidepressants.	Diazepam	139-147	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
12540783-3	2003	In cultured rat astrocytes, diazepam, PK11195, Ro5-4864, and the benzodiazepine binding inhibitor (DBI), which acts on peripheral-type benzodiazepine receptors, induced PTN.	Diazepam	28-36	pleiotrophin	Rattus norvegicus	169-172
12540783-6	2003	Diazepam-induced PTN was insensitive to NOS inhibition and uric acid but was blunted by MK-801, BAPTA-AM, W13, and catalase, suggesting an involvement of NMDA-receptor activation, elevation of the cytosolic Ca(2+) concentration [Ca(2+)](i), and hydrogen peroxide.	Diazepam	0-8	pleiotrophin	Rattus norvegicus	17-20
12540783-9	2003	Astroglial PTN is also found in brains from rats challenged with diazepam, indicating the in vivo relevance of the present findings.	Diazepam	65-73	pleiotrophin	Rattus norvegicus	11-14
12464248-0	2003	Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling.	Diazepam	57-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	79-85
12464248-1	2003	The structural basis for the cooperativity of diazepam oxidation catalyzed by human cytochrome P450 3A4 (CYP3A4) and 40 mutants has been investigated.	Diazepam	46-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-103
12464248-1	2003	The structural basis for the cooperativity of diazepam oxidation catalyzed by human cytochrome P450 3A4 (CYP3A4) and 40 mutants has been investigated.	Diazepam	46-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-111
12600694-4	2003	CART-(55-102)-induced anxiogenic-like behavior in this task was attenuated by widely prescribed anxiolytics such as diazepam and buspirone.	Diazepam	116-124	CART prepropeptide	Mus musculus	0-4
12600694-6	2003	Both diazepam and buspirone significantly reversed CART-(55-102)-induced anxiogenic-like behavior in social interaction tests.	Diazepam	5-13	CART prepropeptide	Mus musculus	51-55
12494402-10	2003	Diazepam with affinity for alpha1, alpha2, alpha3, and alpha5 subunits inhibited the binding in all brain regions.	Diazepam	0-8	adrenoceptor alpha 1D	Homo sapiens	27-61
12548383-8	2003	Ethanol, diazepam, and chloralhydrate significantly inhibited GLUT1 function.	Diazepam	9-17	solute carrier family 2 member 1	Homo sapiens	62-67
12548383-10	2003	Diazepam, chloralhydrate, and ethanol are inhibitors of GLUT1 function in vitro and might potentiate the effects of GLUT1-mediated glucose transport in patients with GLUT1 deficiency syndrome.	Diazepam	0-8	solute carrier family 2 member 1	Homo sapiens	56-61
12548383-10	2003	Diazepam, chloralhydrate, and ethanol are inhibitors of GLUT1 function in vitro and might potentiate the effects of GLUT1-mediated glucose transport in patients with GLUT1 deficiency syndrome.	Diazepam	0-8	solute carrier family 2 member 1	Homo sapiens	116-121
24930414-6	2003	Although there is insufficient evidence, a substantial inhibition of CYP 3A3/4 by venlafaxine could result in a meaningful increase in plasma levels of venlafaxine, O-desmethylvenlafaxine, alprazolam and diazepam, particularly in patients who are CYP 2D6 deficient.	Diazepam	204-212	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-76
14626449-1	2003	High levels of peripheral-type benzodiazepine receptor (PBR), the alternative-binding site for diazepam, are part of the aggressive human breast cancer cell phenotype in vitro.	Diazepam	95-103	translocator protein	Homo sapiens	15-54
14626449-1	2003	High levels of peripheral-type benzodiazepine receptor (PBR), the alternative-binding site for diazepam, are part of the aggressive human breast cancer cell phenotype in vitro.	Diazepam	95-103	translocator protein	Homo sapiens	56-59
12369258-3	2002	The anxiolytic action of the acute treatment with DZP was inhibited by the central administration of NKA and Trp-7 but not by SP.	Diazepam	50-53	tachykinin 1	Mus musculus	101-104
12228192-5	2002	Quinidine, a stimulant of CYP3A4-mediated diclofenac 5-hydroxylation, did not affect the inactivation of CYP3A4 assessed by testosterone 6 beta-hydroxylation activity but accelerated the inactivation assessed by diazepam 3-hydroxylation activity.	Diazepam	212-220	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	26-32
12227198-4	2002	When the effects of the aqueous extract of CLE (100 mg/kg) was compared to diazepam, it showed similar sedative and anticonvulsant effects to those produced by diazepam (5 mg/kg).	Diazepam	160-168	RNA transcription, translation and transport factor	Homo sapiens	43-46
12097476-4	2002	We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (-/-) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (-/-) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice.	Diazepam	279-287	glutamic acid decarboxylase 2	Mus musculus	106-112
12097476-4	2002	We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (-/-) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (-/-) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice.	Diazepam	279-287	glutamic acid decarboxylase 2	Mus musculus	186-192
12097476-4	2002	We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (-/-) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (-/-) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice.	Diazepam	279-287	glutamic acid decarboxylase 2	Mus musculus	186-192
12369258-3	2002	The anxiolytic action of the acute treatment with DZP was inhibited by the central administration of NKA and Trp-7 but not by SP.	Diazepam	50-53	transient receptor potential cation channel, subfamily C, member 7	Mus musculus	109-114
11919649-0	2002	Diazepam potentiates the effects of endogenous catecholamines on contractility and cyclic AMP levels in rat ventricular myocardium.	Diazepam	0-8	transmembrane serine protease 5	Rattus norvegicus	90-93
11927837-1	2002	CYP2C19 is a polymorphically expressed cytochrome P450 responsible for the metabolism of several clinically used drugs, including some barbiturates, diazepam, proguanil, propranolol and several proton pump inhibitors.	Diazepam	149-157	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
11867528-5	2002	Electrophysiological analysis revealed that the modulation of GABA-induced Cl- current by Zn2+ or diazepam, both of which act at GABA(A) receptors containing gamma subunits, is impaired in hippocampal neurons of p130 knockout mice.	Diazepam	98-106	nucleolar and coiled-body phosphoprotein 1	Mus musculus	212-216
11893390-1	2002	In our earlier communication on urea denaturation of bovine serum albumin (BSA), we showed significant unfolding of domain III along with domain I prior to intermediate formation around 4.6-5.2 M urea based on the binding results of domain specific ligands:chloroform, bilirubin and diazepam for domains I, II and III, respectively.	Diazepam	283-291	albumin	Homo sapiens	60-73
11888910-4	2002	We show that, in vitro, the three mPBR ligands tested (RO5-4864, PK11195, and diazepam) enhanced apoptosis induced by anti-CD95 antibody in Jurkat cells, as demonstrated by mitochondrial transmembrane potential drop and DNA fragmentation.	Diazepam	78-86	Fas cell surface death receptor	Homo sapiens	123-127
12222994-16	2002	Diazepam clearance is clearly diminished in PMs or when inhibitors of CYP2C19 are coprescribed, but the clinical consequences are generally minimal.	Diazepam	0-8	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	70-77
11809931-4	2001	The CD2 variant with two Gly linkers has been shown to have the strongest metal binding affinity to Ca(II) and La(III).	Diazepam	111-118	CD2 molecule	Homo sapiens	4-7
12020046-1	2002	The study investigated in vitro effects of halothane, isoflurane, ketamine, sevoflurane, prilocaine, diazepam, and midazolam on enzymatic activity of human red blood cell glucose-6-phosphate dehydrogenase (G6PD; E.C.	Diazepam	101-109	glucose-6-phosphate dehydrogenase	Homo sapiens	171-204
11717184-0	2001	Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.	Diazepam	79-87	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
11717184-3	2001	We have investigated the hypothesis that CYP3A4 may bind multiple molecules simultaneously using diazepam (DZ) and testosterone (TS).	Diazepam	97-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
11717184-3	2001	We have investigated the hypothesis that CYP3A4 may bind multiple molecules simultaneously using diazepam (DZ) and testosterone (TS).	Diazepam	107-109	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
11587356-3	2001	Diazepam was eluted at ambient temperatures from a reversed-phase C18 column with an acidic (pH 3.5) aqueous mobile phase (10 mM KH2PO4-acetonitrile, 69:31, v/v).	Diazepam	0-8	Bardet-Biedl syndrome 9	Homo sapiens	66-69
11694260-4	2001	CYP2C19 genotype is a major determined factor for metabolisms of S-mephenytoin (S-MP), diazepam, and omeprazole (OP).	Diazepam	87-95	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
11560871-0	2001	Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status.	Diazepam	78-86	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-17
11560871-1	2001	Diazepam is metabolized by CYP2C19 and CYP3A4 in the liver.	Diazepam	0-8	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	27-34
11560871-1	2001	Diazepam is metabolized by CYP2C19 and CYP3A4 in the liver.	Diazepam	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-45
11560871-3	2001	The aim of this study was to assess the effect of diltiazem, a CYP3A4 inhibitor, on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status.	Diazepam	117-125	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-69
11560871-3	2001	The aim of this study was to assess the effect of diltiazem, a CYP3A4 inhibitor, on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status.	Diazepam	117-125	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	141-148
11560871-9	2001	Diltiazem affects the pharmacokinetics of diazepam in the PM and EM groups of CYP2C19.	Diazepam	42-50	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	78-85
11560871-10	2001	Inhibition of CYP3A4 by a concomitant substrate drug like diltiazem may cause a pharmacokinetic interaction with diazepam irrespective of CYP2C19 genotype status, but whether this interaction would reflect a pharmacodynamic change of diazepam remains unconfirmed by our study.	Diazepam	113-121	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20
11560871-10	2001	Inhibition of CYP3A4 by a concomitant substrate drug like diltiazem may cause a pharmacokinetic interaction with diazepam irrespective of CYP2C19 genotype status, but whether this interaction would reflect a pharmacodynamic change of diazepam remains unconfirmed by our study.	Diazepam	234-242	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20
11595754-6	2001	Furthermore, following treatment with antidepressants belonging to several different classes (amitriptyline, clomipramine, mianserin, fluoxetine and paroxetine) significantly increased GDNF release, but which did not occur after treatment with non-antidepressant psychotropic drugs (haloperidol, diazepam and diphenhydramine).	Diazepam	296-304	glial cell derived neurotrophic factor	Rattus norvegicus	185-189
11493022-2	2001	Caspase-8 is a key initiator of apoptosis via extrinsic, death receptor-mediated pathways; we therefore investigated its role in mediating seizure-induced neuronal death evoked by unilateral kainic acid injection into the amygdala of the rat, terminated after 40 min by diazepam.	Diazepam	270-278	caspase 8	Rattus norvegicus	0-9
11575786-0	2001	Application of solid-phase microextraction in the determination of diazepam binding to human serum albumin.	Diazepam	67-75	albumin	Homo sapiens	93-106
11575786-1	2001	In this paper, protein-drug interactions were studied by solid-phase microextraction (SPME) using diazepam binding to human serum albumin as a model system.	Diazepam	98-106	albumin	Homo sapiens	124-137
11842605-5	2001	Based on our data, we suggest that the NPY system is involved in antianxiety effects of diazepam and buspirone.	Diazepam	88-96	neuropeptide Y	Homo sapiens	39-42
11483250-2	2001	Exposure of cells to 10 microM diazepam for 5 days significantly reduced the amounts of alpha(1) and gamma(2) subunit mRNAs, and had no effect on the amount of alpha(4) mRNA.	Diazepam	31-39	crystallin, gamma E	Rattus norvegicus	101-109
11483250-5	2001	Withdrawal of diazepam or imidazenil induced a marked increase in the amount of alpha(4) mRNA; withdrawal of imidazenil also reduced the amounts of alpha(1) and gamma(2) mRNAs.	Diazepam	14-22	crystallin, gamma E	Rattus norvegicus	161-169
11408831-2	2001	Diazepam-induced migration and phagocytosis were inhibited by the peripheral benzodiazepine receptor (PBR) antagonist PK11195 (10 micromol/l).	Diazepam	0-8	translocator protein	Homo sapiens	66-100
11408831-8	2001	Diazepam-induced [Ca2+]i changes depend on a PBR-operated, L-verapamil-sensitive increase in the plasma membrane permeability and subsequent extracellular Ca2+ entry, and contribute to diazepam-induced phagocytosis.	Diazepam	185-193	translocator protein	Homo sapiens	45-48
11408831-2	2001	Diazepam-induced migration and phagocytosis were inhibited by the peripheral benzodiazepine receptor (PBR) antagonist PK11195 (10 micromol/l).	Diazepam	0-8	translocator protein	Homo sapiens	102-105
11408831-8	2001	Diazepam-induced [Ca2+]i changes depend on a PBR-operated, L-verapamil-sensitive increase in the plasma membrane permeability and subsequent extracellular Ca2+ entry, and contribute to diazepam-induced phagocytosis.	Diazepam	0-8	translocator protein	Homo sapiens	45-48
11340971-1	2001	Human serum albumin (HSA) was immobilised on the gold surface of a quartz crystal resonance sensor (QCRS) and exposed to warfarin and diazepam.	Diazepam	134-142	albumin	Homo sapiens	6-25
11468031-0	2001	Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line.	Diazepam	0-8	small nucleolar RNA, C/D box 87	Homo sapiens	52-56
11468031-4	2001	In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells.	Diazepam	90-98	host cell factor C1	Homo sapiens	66-71
11468031-4	2001	In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells.	Diazepam	90-98	translocator protein	Homo sapiens	78-81
11468031-4	2001	In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells.	Diazepam	90-98	small nucleolar RNA, C/D box 87	Homo sapiens	107-111
11468031-4	2001	In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells.	Diazepam	100-102	host cell factor C1	Homo sapiens	66-71
11468031-4	2001	In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells.	Diazepam	100-102	translocator protein	Homo sapiens	78-81
11468031-4	2001	In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells.	Diazepam	100-102	small nucleolar RNA, C/D box 87	Homo sapiens	107-111
11306694-6	2001	Of the diazepam-sensitive GABA(A) receptors (alpha1, alpha2, alpha3, alpha5), alpha5 showed the most divergence, being discriminated by zolpidem in terms of very low affinity, and CL218,872 and CGS9895 with different efficacies.	Diazepam	7-15	adrenoceptor alpha 1D	Homo sapiens	45-51
11353839-0	2001	Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype.	Diazepam	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	55-62
11353839-2	2001	BZs such as diazepam (Dz) potentiate GABA(A) receptor activation.	Diazepam	12-20	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	37-44
11353839-2	2001	BZs such as diazepam (Dz) potentiate GABA(A) receptor activation.	Diazepam	22-24	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	37-44
11417852-10	2001	These results suggest a relevant role of PBR and corticosterone on diazepam-induced changes in inflammation.	Diazepam	67-75	translocator protein	Rattus norvegicus	41-44
11326275-6	2001	We found that the mutation in GABRG2 (encoding the gamma2-subunit) abolished in vitro sensitivity to diazepam, raising the possibility that endozepines do in fact exist and have a physiological role in preventing seizures.	Diazepam	101-109	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	30-36
11349394-7	2001	CONCLUSIONS: Our results suggest that the inhibition of melatonin production induced by diazepam in vivo may be due to a direct action of this benzodiazepine on the pineal gland, through its action on NAT, the key enzyme of melatonin synthesis, and that the control of melatonin production in the Harderian glands may be different from that observed in the pineal gland.	Diazepam	88-96	N-acetyltransferase 1	Rattus norvegicus	201-204
11349394-5	2001	Diazepam reduced the pineal melatonin content (by a factor of 2) and the activity of N-acetyltransferase (NAT) (by a factor of 3.5), as well as plasma melatonin levels (by a factor of 1.5), but had no effects on pineal hydroxyindole-O-methyltransferase activity.	Diazepam	0-8	N-acetyltransferase 1	Rattus norvegicus	85-104
11349394-5	2001	Diazepam reduced the pineal melatonin content (by a factor of 2) and the activity of N-acetyltransferase (NAT) (by a factor of 3.5), as well as plasma melatonin levels (by a factor of 1.5), but had no effects on pineal hydroxyindole-O-methyltransferase activity.	Diazepam	0-8	N-acetyltransferase 1	Rattus norvegicus	106-109
11259499-8	2001	A time-dependent increase in BDNF immunoreactivity was also found by western blot analysis in rats treated with diazepam + pentobarbital.	Diazepam	112-120	brain-derived neurotrophic factor	Rattus norvegicus	29-33
11267656-6	2001	In addition, we found that diazepam inhibited cyclic AMP hydrolysis by the mouse PDE4 subtypes.	Diazepam	27-35	phosphodiesterase 4A	Homo sapiens	81-85
11267656-7	2001	Interestingly, PDE4B was significantly more sensitive to inhibition by both rolipram and diazepam than the PDE4A subtype.	Diazepam	89-97	phosphodiesterase 4B, cAMP specific	Mus musculus	15-20
11594168-8	2001	The aims of this study were to determine the IL1 levels in vivo and in the supernatants of cultures of peripheral blood mononuclear cells (PBMC) stimulated or not with LPS in children with FC and in children with fever without FC and to evaluate the influence of ADH and diazepam (DZ) on IL1 production.	Diazepam	271-279	interleukin 1 alpha	Homo sapiens	45-48
11594168-8	2001	The aims of this study were to determine the IL1 levels in vivo and in the supernatants of cultures of peripheral blood mononuclear cells (PBMC) stimulated or not with LPS in children with FC and in children with fever without FC and to evaluate the influence of ADH and diazepam (DZ) on IL1 production.	Diazepam	281-283	interleukin 1 alpha	Homo sapiens	45-48
11179437-3	2001	To identify the GABA(A) receptor subtypes mediating the action of diazepam on muscle tone, we have assessed the myorelaxant properties of diazepam in alpha2(H101R) and alpha3(H126R) knock-in mice harboring diazepam-insensitive alpha2 or alpha3 GABA(A) receptors, respectively.	Diazepam	138-146	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	150-155
11179437-3	2001	To identify the GABA(A) receptor subtypes mediating the action of diazepam on muscle tone, we have assessed the myorelaxant properties of diazepam in alpha2(H101R) and alpha3(H126R) knock-in mice harboring diazepam-insensitive alpha2 or alpha3 GABA(A) receptors, respectively.	Diazepam	138-146	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	150-155
11179437-4	2001	Whereas in alpha2(H101R) mice the myorelaxant action of diazepam was almost completely abolished at doses up to 10 mg/kg, the same dose induced myorelaxation in both wild-type and alpha3(H126R) mice.	Diazepam	56-64	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	11-16
11179437-5	2001	It was only at a very high dose (30 mg/kg diazepam) that alpha2(H101R) mice showed partial myorelaxation and alpha3(H126R) mice were partially protected from myorelaxation compared with wild-type mice.	Diazepam	42-50	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	57-62
11166325-3	2001	GABA(A)-Rs were tested for their sensitivity to diazepam and PB before and after incubation in phorbol 12-myristate 13-acetate (PMA).	Diazepam	48-56	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	0-7
11167168-9	2001	The percentage of phagocytosing PMNs was less reduced with 20 microg ml(-1) LCT/MCT-diazepam (85.2+/-6.9) than with the same concentration of benzyl-alcohol diluted diazepam (68.8+/-12.2) compared to the control.	Diazepam	84-92	solute carrier family 16 member 1	Homo sapiens	80-83
11222088-4	2001	While bath application of muscimol, DZP, or baclofen suppressed spontaneous activity in CA1 neurons not previously exposed to TMPP, subsequent application of TMPP (10 microM) reversed the actions of muscimol and diazepam, but not baclofen.	Diazepam	36-39	carbonic anhydrase 1	Rattus norvegicus	88-91
11179861-6	2001	Regarding PMN immune functions, diazepam significantly decreased superoxide anion (O(2)(-)) and hydrogen peroxide production (H(2)O(2)) and myeloperoxidase activity (MPO) while ala-gln significantly increased PMN immune functions.	Diazepam	32-40	myeloperoxidase	Homo sapiens	140-155
11510629-6	2001	In drug interaction studies with diazepam, phenytoin and (R)-warfarin, it was shown that esomeprazole has the potential to interact with CYP2C19.	Diazepam	33-41	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	137-144
11523208-4	2001	The comparison between the ischemia group and diazepam-treated group showed that diazepam could obviously decrease the production of glutamate, asparate, MDA and increase the synthesis and release of GABA, SOD and GSH-PX.	Diazepam	46-54	glutathione peroxidase 1	Rattus norvegicus	214-220
11523208-4	2001	The comparison between the ischemia group and diazepam-treated group showed that diazepam could obviously decrease the production of glutamate, asparate, MDA and increase the synthesis and release of GABA, SOD and GSH-PX.	Diazepam	81-89	glutathione peroxidase 1	Rattus norvegicus	214-220
11179861-6	2001	Regarding PMN immune functions, diazepam significantly decreased superoxide anion (O(2)(-)) and hydrogen peroxide production (H(2)O(2)) and myeloperoxidase activity (MPO) while ala-gln significantly increased PMN immune functions.	Diazepam	32-40	myeloperoxidase	Homo sapiens	166-169
10882844-0	2000	Diazepam attenuation of somatostatin binding and effect of somatostatin on accumulation of inositol 1,4,5-trisphosphate in the rat frontoparietal cortex.	Diazepam	0-8	somatostatin	Rattus norvegicus	24-36
11152384-6	2000	GABAergic allosteric modulators (3 or 12 mg/kg diazepam and 50 mg/kg phenobarbital) blocked the appearance of seizure and reduced almost completely the death caused by BAL.	Diazepam	47-55	poly (ADP-ribose) polymerase family, member 9	Mus musculus	168-171
11152384-12	2000	The results reported here demonstrate that GABAergic allosteric modulators (diazepam and phenobarbital) and carbamazepine, a compound that acts by prolonging the recovery of voltage-activated ion channels from inactivation, are able to abolish BAL-induced seizures, while the NMDA antagonist (MK-801) prolonged the latencies for onset of seizures suggesting that modulators of this subtype of glutamate receptor have a modest role on BAL-induced seizures.	Diazepam	76-84	poly (ADP-ribose) polymerase family, member 9	Mus musculus	244-247
11152384-12	2000	The results reported here demonstrate that GABAergic allosteric modulators (diazepam and phenobarbital) and carbamazepine, a compound that acts by prolonging the recovery of voltage-activated ion channels from inactivation, are able to abolish BAL-induced seizures, while the NMDA antagonist (MK-801) prolonged the latencies for onset of seizures suggesting that modulators of this subtype of glutamate receptor have a modest role on BAL-induced seizures.	Diazepam	76-84	poly (ADP-ribose) polymerase family, member 9	Mus musculus	434-437
11113582-0	2000	Diazepam induces FGF-2 mRNA in the hippocampus and striatum.	Diazepam	0-8	fibroblast growth factor 2	Homo sapiens	17-22
11113582-1	2000	starting by 6 h following diazepam injection and returning to approximately control values by 24 h. In situ hybridization showed elevated FGF-2 mRNA labeling in the hippocampal formation, mostly in the pyramidal layer of the CA1 and CA2 subfields and in the dentate gyrus hilar region.	Diazepam	26-34	fibroblast growth factor 2	Homo sapiens	138-143
11113582-2	2000	These results indicate that diazepam treatment up-regulates FGF-2 expression in select regions of the brain and suggest that GABA may promote neuroplasticity in concert with FGF-2.	Diazepam	28-36	fibroblast growth factor 2	Homo sapiens	60-65
11113582-2	2000	These results indicate that diazepam treatment up-regulates FGF-2 expression in select regions of the brain and suggest that GABA may promote neuroplasticity in concert with FGF-2.	Diazepam	28-36	fibroblast growth factor 2	Homo sapiens	174-179
11100148-3	2000	Here we show that, with low concentrations of GABA, diazepam produces a biphasic potentiation for the alpha1beta2gamma2-receptor channel, with distinct components in the nanomolar and micromolar concentration ranges.	Diazepam	52-60	adrenoceptor alpha 1D	Homo sapiens	102-119
11038161-7	2000	Tolbutamide was metabolized by CYP2C9 (70%) and CYP2C19 (30%), diazepam by CYP2C19 (100%), ibuprofen by CYP2C9 (90%) and CYP2C19 (10%), and omeprazole by CYP2C19 (68%) and CYP3A4 (32%).	Diazepam	63-71	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	75-82
11038161-7	2000	Tolbutamide was metabolized by CYP2C9 (70%) and CYP2C19 (30%), diazepam by CYP2C19 (100%), ibuprofen by CYP2C9 (90%) and CYP2C19 (10%), and omeprazole by CYP2C19 (68%) and CYP3A4 (32%).	Diazepam	63-71	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	75-82
11038161-7	2000	Tolbutamide was metabolized by CYP2C9 (70%) and CYP2C19 (30%), diazepam by CYP2C19 (100%), ibuprofen by CYP2C9 (90%) and CYP2C19 (10%), and omeprazole by CYP2C19 (68%) and CYP3A4 (32%).	Diazepam	63-71	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	75-82
11038248-0	2000	Induction of NGFI-B mRNA following contextual fear conditioning and its blockade by diazepam.	Diazepam	84-92	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	13-19
11038248-6	2000	In a subsequent experiment, the effects of pretreatment with the anxiolytic drug, diazepam, on fear conditioning and the concomitant increases in NGFI-B mRNA were investigated.	Diazepam	82-90	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	146-152
11038248-9	2000	Although diazepam blocked fear conditioning while the 40% propylene glycol, 10% ethanol vehicle solution did not, both diazepam and the vehicle reduced the conditioning-induced increase in NGFI-B expression in the LaDL.	Diazepam	119-127	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	189-195
11038248-10	2000	In contrast, the fear-conditioning-induced NGFI-B increase in the neocortex was blocked by diazepam, but not by the vehicle.	Diazepam	91-99	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	43-49
10856435-12	2000	PBR and its putative endogenous ligand diazepam-binding inhibitor are possibly involved in the regulation of cell proliferation of human breast cancer cell lines.	Diazepam	39-47	translocator protein	Homo sapiens	0-3
10973530-4	2000	Conversely, both doses of diazepam significantly improved the acquisition of CAR in estrous rats and in OVX rats injected with estradiol.	Diazepam	26-34	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	77-80
10882844-2	2000	In view of the important role of brain somatostatin (SRIF) in the cognitive function of rats, this study sought to determine if the benzodiazepine, diazepam, alters somatostatinergic system in the rat frontoparietal cortex.	Diazepam	148-156	somatostatin	Rattus norvegicus	39-51
10856895-0	2000	Diazepam-binding inhibitor/acyl-CoA-binding protein mRNA and peripheral benzodiazepine receptor mRNA in endocrine and immune tissues after prenatal diazepam exposure of male and female rats.	Diazepam	148-156	diazepam binding inhibitor	Rattus norvegicus	0-51
10856895-5	2000	Prenatal diazepam increased DBI/ACBP mRNA expression in male fetal adrenal and in fetal and PN14 testis.	Diazepam	9-17	diazepam binding inhibitor	Rattus norvegicus	28-31
10856895-5	2000	Prenatal diazepam increased DBI/ACBP mRNA expression in male fetal adrenal and in fetal and PN14 testis.	Diazepam	9-17	diazepam binding inhibitor	Rattus norvegicus	32-36
10856895-9	2000	The effects of prenatal diazepam were superimposed on treatment-independent sex differences in DBI/ACBP mRNA and PBR mRNA expression.	Diazepam	24-32	diazepam binding inhibitor	Rattus norvegicus	95-98
10856895-9	2000	The effects of prenatal diazepam were superimposed on treatment-independent sex differences in DBI/ACBP mRNA and PBR mRNA expression.	Diazepam	24-32	diazepam binding inhibitor	Rattus norvegicus	99-103
10856895-9	2000	The effects of prenatal diazepam were superimposed on treatment-independent sex differences in DBI/ACBP mRNA and PBR mRNA expression.	Diazepam	24-32	translocator protein	Rattus norvegicus	113-116
10886465-8	2000	CYP2C19 enzyme participates in the metabolism of omeprazole, propranolol and psychotropic drugs such as hexobarbital, diazepam, citalopram, imipramine, clomipramine and amitriptyline.	Diazepam	118-126	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
10959491-7	2000	Our results suggest that, although diazepam and the new benzodiazepines have chemical differences, they both presented an inhibitory effect on acetylcholinesterase and ATPDase activities.	Diazepam	35-43	acetylcholinesterase	Rattus norvegicus	143-163
10959491-7	2000	Our results suggest that, although diazepam and the new benzodiazepines have chemical differences, they both presented an inhibitory effect on acetylcholinesterase and ATPDase activities.	Diazepam	35-43	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	168-175
10757990-2	2000	Enzyme kinetics for diazepam, erythromycin, nifedipine, and testosterone metabolism have been determined for both mutants and wild-type CYP3A4.	Diazepam	20-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	136-142
11021974-7	2000	The effect of diazepam on both behaviour and NPY-LI was antagonized by flumazenil (15 mg/kg).	Diazepam	14-22	neuropeptide Y	Rattus norvegicus	45-48
11021974-8	2000	Apart from supporting the role of the NPY system in fear and anxiety, the results of this study suggest that NPY is involved in the anxiolytic effects of diazepam and buspirone and that the effect of diazepam is mediated by benzodiazepine receptors.	Diazepam	154-162	neuropeptide Y	Rattus norvegicus	109-112
11021974-8	2000	Apart from supporting the role of the NPY system in fear and anxiety, the results of this study suggest that NPY is involved in the anxiolytic effects of diazepam and buspirone and that the effect of diazepam is mediated by benzodiazepine receptors.	Diazepam	200-208	neuropeptide Y	Rattus norvegicus	38-41
10859494-8	2000	Induction of the PACAP gene expression following KA-induced seizure was significantly reduced by pretreatment with diazepam or MK-801 (nonselective N-methly-D-aspartate receptor antagonist).	Diazepam	115-123	adenylate cyclase activating polypeptide 1	Rattus norvegicus	17-22
10771285-3	2000	Our results showed that CYP3A4/5 contributes to testosterone 6beta-hydroxylation, taxol phenol formation, diazepam 3-hydroxylation, diazepam N-demethylation, and aflatoxin B1 3-hydroxylation in human liver by 79.2%, 81.5%, 73.	Diazepam	106-114	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-30
10771285-3	2000	Our results showed that CYP3A4/5 contributes to testosterone 6beta-hydroxylation, taxol phenol formation, diazepam 3-hydroxylation, diazepam N-demethylation, and aflatoxin B1 3-hydroxylation in human liver by 79.2%, 81.5%, 73.	Diazepam	132-140	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-30
10771285-5	2000	CYP2E1 contributes to chlorzoxazone 6-hydroxylation, p-nitroanisole O-demethylation, and toluene hydroxylation by 45.8%, 27.7% and 44.2% respectively, and CYP2C8/9/19 contribute to diazepam N-demethylation by 30.6%.	Diazepam	181-189	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
10771285-6	2000	The additive contribution (75.3%) of human CYP3A and CYP2C to diazepam N-demethylation was also observed in the presence of both anti-CYP3A4/5 and anti-CYP2C8/9/19 monoclonal antibodies.	Diazepam	62-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-48
10771285-6	2000	The additive contribution (75.3%) of human CYP3A and CYP2C to diazepam N-demethylation was also observed in the presence of both anti-CYP3A4/5 and anti-CYP2C8/9/19 monoclonal antibodies.	Diazepam	62-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	134-140
10771285-6	2000	The additive contribution (75.3%) of human CYP3A and CYP2C to diazepam N-demethylation was also observed in the presence of both anti-CYP3A4/5 and anti-CYP2C8/9/19 monoclonal antibodies.	Diazepam	62-70	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	152-158
10727623-0	2000	Differential expression of EGR-1 mRNA in the amygdala following diazepam in contextual fear conditioning.	Diazepam	64-72	early growth response 1	Rattus norvegicus	27-32
10762378-0	2000	Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal-induced c-fos expression in nucleus accumbens.	Diazepam	47-55	FBJ osteosarcoma oncogene	Mus musculus	143-148
10727623-4	2000	It was therefore hypothesized that diazepam would block both contextual fear and the concomitant increase in EGR-1 mRNA expression in the LA induced by fear conditioning.	Diazepam	35-43	early growth response 1	Rattus norvegicus	109-114
10727623-6	2000	Diazepam blocked the fear-conditioning-induced increase in EGR-1 expression in the LA.	Diazepam	0-8	early growth response 1	Rattus norvegicus	59-64
10727623-7	2000	In addition, diazepam significantly increased EGR-1 mRNA expression in the central nucleus of the amygdala (CeA) in a dose-dependent manner.	Diazepam	13-21	early growth response 1	Rattus norvegicus	46-51
10727623-7	2000	In addition, diazepam significantly increased EGR-1 mRNA expression in the central nucleus of the amygdala (CeA) in a dose-dependent manner.	Diazepam	13-21	carcinoembryonic antigen gene family 4	Rattus norvegicus	108-111
10727623-8	2000	The results reveal differential regulation of EGR-1 by diazepam in the central and lateral nuclei of the amygdala suggesting that these two amygdala nuclei act in a reciprocal manner during the anxiolytic and amnesic action of the benzodiazepine agonist.	Diazepam	55-63	early growth response 1	Rattus norvegicus	46-51
10821163-5	2000	Ketoconazole exhibited potent inhibition of both CYP3A4-catalysed metabolism of phenanthrene, testosterone, diazepam (IC50 = 0.03-0.5 microM) and CYP1A1-catalysed deethylation of 7-ethoxycoumarin (0.33 microM).	Diazepam	108-116	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55
10724170-7	2000	Short-term presynaptic dynamics reflected a synaptic reorganization in GAD65 knockout mice after chronic diazepam treatment.	Diazepam	105-113	glutamic acid decarboxylase 2	Mus musculus	71-76
10728882-10	2000	Cells transfected with alpha1 and gamma2S cDNAs displayed small diazepam and loreclezole responsive GABA-activated currents.	Diazepam	64-72	adrenoceptor alpha 1D	Homo sapiens	23-41
10566958-7	2000	Injection of gamma2 subunit aODNs increased the GABA Emax; reversed the modulatory efficacy of diazepam from enhancement to inhibition of GABA-stimulation; and reduced the antagonist effect of bicuculline.	Diazepam	95-103	crystallin, gamma E	Rattus norvegicus	13-19
10594919-4	2000	Whereas the mitochondrial benzodiazepine/diazepam binding inhibitor (DBI) receptor (MBR) was below the immunohistochemical detection limit in normal mice (except in the choroid plexus and ependyma cells), it was significantly expressed in many reactive astrocytes of jp and shi mice brains.	Diazepam	41-49	diazepam binding inhibitor	Mus musculus	69-72
10659949-12	2000	The metabolism of diazepam was also investigated with baculovirus-expressed human CYP enzymes (2C8, 2C9-ARG, 2C9-CYS, 2C19, 3A4, 3A4+cytochrome b5 and 3A5) and evidence was obtained to suggest the formation of temazepam and oxazepam by enzymes of the CYP3A subfamily.	Diazepam	18-26	peptidylprolyl isomerase G	Homo sapiens	82-85
11015034-4	2000	Diazepam decreased the amplitude of the middle-latency P30 component and increased the amplitudes of the late-latency N60 and P67 components.	Diazepam	0-8	methionyl aminopeptidase 2	Rattus norvegicus	126-129
10633493-5	2000	The enhancement of diazepam action by SHPE was naloxone reversible, region-specific, and correlated with the time course of preproenkephalin expression.	Diazepam	19-27	proenkephalin	Homo sapiens	124-140
10659949-5	2000	Diazepam, another CYP monooxygenase substrate, was also metabolized by porcine hepatocytes but not with porcine enterocytes, thus indicating differences in the metabolic competence of the liver and the gut.	Diazepam	0-8	peptidylprolyl isomerase G	Homo sapiens	18-21
10659949-12	2000	The metabolism of diazepam was also investigated with baculovirus-expressed human CYP enzymes (2C8, 2C9-ARG, 2C9-CYS, 2C19, 3A4, 3A4+cytochrome b5 and 3A5) and evidence was obtained to suggest the formation of temazepam and oxazepam by enzymes of the CYP3A subfamily.	Diazepam	18-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	251-256
10674919-2	1999	Using either the calcium channel blocker verapamil or anti-calmodulin drugs (diazepam, trifluoperazine,) the cytoprotective effect of prostacyclin can be inhibited.	Diazepam	77-85	calmodulin 1	Rattus norvegicus	59-69
10613621-1	1999	OBJECTIVE: To determine whether the gene dosage of CYP2C19 affects the metabolism of diazepam and desmethyldiazepam in healthy Chinese subjects.	Diazepam	85-93	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	51-58
10613621-7	1999	CONCLUSION: The presence of a single-nucleotide polymorphism (G681A) of the CYP2C19 gene cosegregates with the impaired metabolism of diazepam and desmethyldiazepam among Chinese subjects in a gene-dosage effect manner.	Diazepam	134-142	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	76-83
10594078-6	1999	Finally, long-term potentiation (LTP), not found in the dentate gyrus of Tg-SOD-1 mice, could be restored by local blockade of inhibition and could be blocked in control mice by injection of diazepam, which amplifies inhibition.	Diazepam	191-199	superoxide dismutase 1, soluble	Mus musculus	76-81
10602344-8	1999	High-dose administration of diazepam (10 mg kg-1) or triazolam (1 mg kg-1) reduced mPer1 mRNA level 1 h after treatment in the cerebellum.	Diazepam	28-36	period circadian clock 1	Mus musculus	83-88
10602344-10	1999	Reduced expression of mPer1 by diazepam treatment was transient.	Diazepam	31-39	period circadian clock 1	Mus musculus	22-27
10602344-17	1999	Diazepam and tandospirone inhibited the expression of mPer1 mRNA in the primary cultured cerebellum granule cells.	Diazepam	0-8	period circadian clock 1	Mus musculus	54-59
10657538-3	1999	Amygdala NPY-LI decreased after acute diazepam (3 mg/kg) or buspirone (1.5 mg/kg) and increased after subchronic treatment with both doses of diazepam and after chronic buspirone (1.5 mg/kg) treatment.	Diazepam	38-46	neuropeptide Y	Rattus norvegicus	9-12
10657538-3	1999	Amygdala NPY-LI decreased after acute diazepam (3 mg/kg) or buspirone (1.5 mg/kg) and increased after subchronic treatment with both doses of diazepam and after chronic buspirone (1.5 mg/kg) treatment.	Diazepam	142-150	neuropeptide Y	Rattus norvegicus	9-12
10657538-4	1999	Both diazepam and buspirone given in subchronic and chronic doses decreased NPY-LI levels in the nucleus accumbens.	Diazepam	5-13	neuropeptide Y	Rattus norvegicus	76-79
10657538-5	1999	Hypothalamic NPY-LI changed only after chronic treatment: it decreased after diazepam and increased after buspirone (5 mg/kg).	Diazepam	77-85	neuropeptide Y	Rattus norvegicus	13-16
10657538-6	1999	NPY-LI content in the frontal cortex decreased after subchronic diazepam (3 mg/kg) treatment and slightly increased after buspirone.	Diazepam	64-72	neuropeptide Y	Rattus norvegicus	0-3
10657538-7	1999	The study has shown that both diazepam and buspirone affect NPY-LI levels in rats.	Diazepam	30-38	neuropeptide Y	Rattus norvegicus	60-63
10525096-7	1999	Therefore, mAb(3A4a) was used to assess the quantitative role of CYP3A4/5 to the metabolism of testosterone and diazepam in five human liver microsomes.	Diazepam	112-120	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-71
10525096-8	1999	The results showed that CYP3A4 and CYP3A5 contribute >95% to both testosterone 6beta-hydroxylation and diazepam 3-hydroxylation and 52 to 73% to diazepam N-demethylation, respectively.	Diazepam	106-114	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-30
10525096-8	1999	The results showed that CYP3A4 and CYP3A5 contribute >95% to both testosterone 6beta-hydroxylation and diazepam 3-hydroxylation and 52 to 73% to diazepam N-demethylation, respectively.	Diazepam	106-114	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	35-41
10525096-8	1999	The results showed that CYP3A4 and CYP3A5 contribute >95% to both testosterone 6beta-hydroxylation and diazepam 3-hydroxylation and 52 to 73% to diazepam N-demethylation, respectively.	Diazepam	148-156	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-30
10525096-8	1999	The results showed that CYP3A4 and CYP3A5 contribute >95% to both testosterone 6beta-hydroxylation and diazepam 3-hydroxylation and 52 to 73% to diazepam N-demethylation, respectively.	Diazepam	148-156	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	35-41
10525096-11	1999	The selectivity of ketoconazole, a chemical inhibitor of CYP3A4, was probed with mAb(3A4a) and was shown to be highly concentration dependent in the diazepam N-demethylation by human liver microsomes.	Diazepam	149-157	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	57-63
10440734-3	1999	Anxiety-like behavior was reduced in both NCAM+/+ and NCAM-/- mice by systemic administration of the benzodiazepine agonist diazepam and the 5-HT1A receptor agonists buspirone and 8-OH-DPAT.	Diazepam	124-132	neural cell adhesion molecule 1	Mus musculus	42-46
10707884-2	1999	This CCK-RF was found to be identical to the porcine diazepam binding inhibitor by peptide sequencing and mass spectrometry analysis.	Diazepam	53-61	cholecystokinin	Homo sapiens	5-8
10440734-3	1999	Anxiety-like behavior was reduced in both NCAM+/+ and NCAM-/- mice by systemic administration of the benzodiazepine agonist diazepam and the 5-HT1A receptor agonists buspirone and 8-OH-DPAT.	Diazepam	124-132	neural cell adhesion molecule 1	Mus musculus	54-58
10483511-5	1999	The interaction studies showed that oleamide potentiated the inhibitory effect of diazepam (CAS 439-14-5) and antagonized the stimulatory effect of ethanol, methamphetamine, and caffeine, respectively.	Diazepam	82-90	breast cancer anti-estrogen resistance 1	Mus musculus	92-95
10411572-1	1999	Cytochrome P-450 (CYP) 2C19 is responsible for the metabolism of a number of therapeutic agents such as S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.	Diazepam	164-172	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-27
10462056-3	1999	Attempts were made to characterize its binding site using as competitors warfarin, phenylbutazone and diazepam, which bind in a specific site or region on the HSA.	Diazepam	102-110	albumin	Homo sapiens	159-162
10462056-4	1999	Fluorescence polarization measurements and spectrofluorimetric results suggest that diazepam and Promen bind at different but interacting binding sites on the HSA.	Diazepam	84-92	albumin	Homo sapiens	159-162
10418969-2	1999	Enzyme induction was assessed through the use of several diagnostic markers, i.e. testosterone, midazolam (MDZ), diazepam (DZP) and 7-ethoxyresorufin for CYP-dependent enzyme reactions; and AZT for UGT-dependent enzyme reactions.	Diazepam	113-121	peptidylprolyl isomerase G	Homo sapiens	154-157
10418961-3	1999	When human serum albumin (HSA) was incubated with 0.5 M glucose for 5 days, the unbound fractions of diazepam and warfarin were increased by 41 and 35%, respectively, less than that caused by glucuronic acid which increased the unbound fractions by 90% for diazepam and 420% for warfarin.	Diazepam	257-265	albumin	Homo sapiens	11-24
10458100-11	1999	These results imply that dopamine D2 receptor is involved in the induction of hyperphagia by DZP.	Diazepam	93-96	dopamine receptor D2	Mus musculus	25-45
10359672-0	1999	Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.	Diazepam	139-147	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	74-93
10359672-5	1999	In the present study, diazepam, temazepam and nordiazepam were employed as substrates of CYP3A4 to propose a kinetic model.	Diazepam	22-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	89-95
10418969-9	1999	DZP one, which is governed by various CYPs, including CYP3A, was also investigated.	Diazepam	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-59
10418961-3	1999	When human serum albumin (HSA) was incubated with 0.5 M glucose for 5 days, the unbound fractions of diazepam and warfarin were increased by 41 and 35%, respectively, less than that caused by glucuronic acid which increased the unbound fractions by 90% for diazepam and 420% for warfarin.	Diazepam	101-109	albumin	Homo sapiens	11-24
10418969-2	1999	Enzyme induction was assessed through the use of several diagnostic markers, i.e. testosterone, midazolam (MDZ), diazepam (DZP) and 7-ethoxyresorufin for CYP-dependent enzyme reactions; and AZT for UGT-dependent enzyme reactions.	Diazepam	123-126	peptidylprolyl isomerase G	Homo sapiens	154-157
10394992-11	1999	Overall, the present findings indicate that except for one RA behaviour and escape responses, the 5-HT1A receptor ligands studied modified the same defensive behaviours as diazepam, suggesting potential therapeutic efficacy in the management of anxiety disorders.	Diazepam	172-180	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	98-113
11819434-3	1999	The amount of CL-1 cells was 2.13X10(8) and the total amount of albumin synthesis reached 71.23&mgr;g,urea synthesis 23.32mg and diazepam transformation 619.7ug respectively.	Diazepam	133-141	adhesion G protein-coupled receptor L1	Homo sapiens	14-18
11819434-5	1999	The amounts of albumin synthesis, urea synthesis and diazepam transformation were 39.8 times, 41.6 times and 33.3 times those of conventional cultivation, respec-tively.CONCLUSION:The human liver cell line CL-1 can be cultivated to a high density with Cytodex-3 and has better biological functions.	Diazepam	53-61	adhesion G protein-coupled receptor L1	Homo sapiens	206-210
10343173-5	1999	The effect of diazepam on the stress-induced decrease in hippocampal glucocorticoid receptor mRNA was reversed by Ro-15-1788, suggesting that it is mediated by central benzodiazepine receptors, i.e. GABA-A.	Diazepam	14-22	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	69-92
10070046-0	1999	Diazepam-binding inhibitor33-50 elicits Ca2+ oscillation and CCK secretion in STC-1 cells via L-type Ca2+ channels.	Diazepam	0-8	cholecystokinin	Rattus norvegicus	61-64
10363938-0	1999	Diazepam induces FGF-2 and its mRNA in the spinal cord.	Diazepam	0-8	fibroblast growth factor 2	Rattus norvegicus	17-22
10363938-2	1999	The GABA agonist diazepam was systemically injected in adult rats, and the expression of FGF-2 was examined in the cervical spinal cord region between 6 h and 7 days post-injection.	Diazepam	17-25	fibroblast growth factor 2	Rattus norvegicus	89-94
10363938-5	1999	Results showing that diazepam up-regulates FGF-2 expression in the spinal cord suggest that GABA may promote neuroplasticity in concert with FGF-2.	Diazepam	21-29	fibroblast growth factor 2	Rattus norvegicus	43-48
10363938-5	1999	Results showing that diazepam up-regulates FGF-2 expression in the spinal cord suggest that GABA may promote neuroplasticity in concert with FGF-2.	Diazepam	21-29	fibroblast growth factor 2	Rattus norvegicus	141-146
10221756-1	1999	In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an "anxiogenic" drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam.	Diazepam	304-312	cholecystokinin	Rattus norvegicus	27-42
10221756-1	1999	In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an "anxiogenic" drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam.	Diazepam	304-312	cholecystokinin	Rattus norvegicus	44-47
10221756-1	1999	In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an "anxiogenic" drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam.	Diazepam	304-312	cholecystokinin	Rattus norvegicus	220-223
9974124-1	1999	Peripheral benzodiazepine receptors (PBR) and their endogenous ligands, the diazepam-binding inhibitor derived-peptides, are present in Schwann cells in the peripheral nervous system.	Diazepam	76-84	translocator protein	Rattus norvegicus	0-35
10227577-5	1999	In human and rat liver, CYP3A isoforms have been implicated in mifepristone clearance and mifepristone administration to rats has also been shown to induce CYP3A enzymes and the associated diazepam C3-hydroxylase activity (Cheesman, Mason and Reilly, J.	Diazepam	189-197	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	24-29
9990087-4	1999	Additionally, GAD65-deficient mice have a diminished response to the anxiolytics diazepam and pentobarbital, both of which interact with GABA-A receptors in a GABA-dependent fashion to facilitate GABAergic neurotransmission.	Diazepam	81-89	glutamic acid decarboxylase 2	Mus musculus	14-19
10190045-0	1999	Human, rat and crocodile liver microsomal monooxygenase activities measured using diazepam and nifedipine: effects of CYP3A inhibitors and relationship to immunochemically detected CYP3A apoprotein.	Diazepam	82-90	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	31-55
10190045-5	1999	Enzyme inhibition studies showed that diazepam C3-hydroxylase of male rat liver was attributable to CYP3A but corresponding results for female rats suggested a contribution from non-CYP3A enzyme.	Diazepam	38-46	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	100-105
10190045-6	1999	Western blotting with immunochemical detection using anti-CYP3A4 IgG suggested the presence of putative CYP3A apoprotein in male and female crocodile liver samples and inhibition studies with diazepam as substrate suggested the presence of CYP3A subfamily monooxygenase activity in these enzyme preparations.	Diazepam	192-200	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	104-109
9974124-1	1999	Peripheral benzodiazepine receptors (PBR) and their endogenous ligands, the diazepam-binding inhibitor derived-peptides, are present in Schwann cells in the peripheral nervous system.	Diazepam	76-84	translocator protein	Rattus norvegicus	37-40
20575772-0	1999	Effect of diazepam on growth hormone secretion in abstinent alcoholic men.	Diazepam	10-18	growth hormone 1	Homo sapiens	22-36
10579469-7	1999	The present data were explained on the basis of a synergistically action for diazepam through peripheral type binding sites (PBR) present in both adrenals and macrophages, stimulating adrenal glucocorticoid production and altering the macrophage cytokine network.	Diazepam	77-85	resistance to Paracoccidioides brasiliensis	Mus musculus	125-128
9987027-9	1999	Diazepam-induced ataxia in alpha 6 -/- mice could be reversed by the benzodiazepine site antagonist flumazenil, indicating the involvement of the remaining alpha 1 beta 2/3 gamma 2 GABAA receptors of the granule cells.	Diazepam	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	27-36
9843158-4	1998	At low micromolar concentrations, the PBR antagonist PK 11195, atrial natriuretic peptide, and protoporhyrin IX, which are known to interact with the PBR, attenuated (16-100%) the effects of ammonia, whereas the PBR agonists Ro5-4864, diazepam binding inhibitor (DBI51-70), and octadecaneuropeptide exacerbated (10-15%) the effects of ammonia.	Diazepam	235-243	translocator protein	Homo sapiens	38-41
9843158-4	1998	At low micromolar concentrations, the PBR antagonist PK 11195, atrial natriuretic peptide, and protoporhyrin IX, which are known to interact with the PBR, attenuated (16-100%) the effects of ammonia, whereas the PBR agonists Ro5-4864, diazepam binding inhibitor (DBI51-70), and octadecaneuropeptide exacerbated (10-15%) the effects of ammonia.	Diazepam	235-243	translocator protein	Homo sapiens	150-153
9843158-4	1998	At low micromolar concentrations, the PBR antagonist PK 11195, atrial natriuretic peptide, and protoporhyrin IX, which are known to interact with the PBR, attenuated (16-100%) the effects of ammonia, whereas the PBR agonists Ro5-4864, diazepam binding inhibitor (DBI51-70), and octadecaneuropeptide exacerbated (10-15%) the effects of ammonia.	Diazepam	235-243	translocator protein	Homo sapiens	150-153
9843158-5	1998	At micromolar concentrations, diazepam, which interacts with both the PBR and the central-type benzodiazepine receptor (CBR), increased swelling by 11%, whereas flumazenil, a CBR antagonist, had no effect.	Diazepam	30-38	translocator protein	Homo sapiens	70-73
9843158-5	1998	At micromolar concentrations, diazepam, which interacts with both the PBR and the central-type benzodiazepine receptor (CBR), increased swelling by 11%, whereas flumazenil, a CBR antagonist, had no effect.	Diazepam	30-38	cannabinoid receptor 1	Homo sapiens	82-118
9843158-5	1998	At micromolar concentrations, diazepam, which interacts with both the PBR and the central-type benzodiazepine receptor (CBR), increased swelling by 11%, whereas flumazenil, a CBR antagonist, had no effect.	Diazepam	30-38	cannabinoid receptor 1	Homo sapiens	120-123
9843158-5	1998	At micromolar concentrations, diazepam, which interacts with both the PBR and the central-type benzodiazepine receptor (CBR), increased swelling by 11%, whereas flumazenil, a CBR antagonist, had no effect.	Diazepam	30-38	cannabinoid receptor 1	Homo sapiens	175-178
9776385-4	1998	However, 39 h following subchronic 5-day administration of diazepam twice daily (bid) at 3.0 mg/kg, diazepam was devoid of anxiolytic activity at 1.0 mg/kg, as measured by no difference in open arm exploration time compared to vehicle control, while the 3.0 mg/kg dose still produced a significant (P < 0.05) 175% increase in open arm exploration time.	Diazepam	59-67	BH3 interacting domain death agonist	Rattus norvegicus	81-84
9776316-5	1998	Furthermore, administration of either the benzodiazepine receptor agonist diazepam or the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine prevented the increase in urinary isatin excretion induced by acute food deprivation, whereas the dopamine-beta-hydroxylase inhibitor diethyldithiocarbamate proved ineffective.	Diazepam	74-82	dopamine beta-hydroxylase	Rattus norvegicus	243-268
9792215-8	1998	AChE activity was altered by imipramine (1.0-2.0 mM) and by diazepam (0.5-2.0 mM).	Diazepam	60-68	acetylcholinesterase	Rattus norvegicus	0-4
9817074-4	1998	Two Pb-binding polypeptides were identified, thymosin beta 4 (T beta 4, 5 kDa) and acyl-CoA binding protein (ACBP, 9 kDa, also known as diazepam binding inhibitor, DBI).	Diazepam	136-144	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	83-107
9817074-4	1998	Two Pb-binding polypeptides were identified, thymosin beta 4 (T beta 4, 5 kDa) and acyl-CoA binding protein (ACBP, 9 kDa, also known as diazepam binding inhibitor, DBI).	Diazepam	136-144	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	109-113
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	39-47	angiotensinogen	Homo sapiens	194-208
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	39-47	angiotensinogen	Homo sapiens	210-216
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	39-47	angiogenin	Homo sapiens	210-213
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	39-47	angiotensin II receptor type 1	Homo sapiens	287-290
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	49-51	angiotensinogen	Homo sapiens	194-208
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	49-51	angiotensinogen	Homo sapiens	210-216
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	49-51	angiogenin	Homo sapiens	210-213
9665310-1	1998	We had previously discovered that both diazepam (DZ) and ethanol inhibited long-term potentiation (LTP) in medial perforant path-dentate granule cell synapses and the inhibition was mediated by angiotensin II (Ang II) because it could be blocked by pretreatment with losartan, an Ang II AT1 receptor antagonist.	Diazepam	49-51	angiotensin II receptor type 1	Homo sapiens	287-290
9666160-3	1998	The purpose of the present study was to determine the comparative abilities of PNU-101017 versus the full agonist diazepam to attenuate post-ischemic CA1 damage.	Diazepam	114-122	carbonic anhydrase 1	Homo sapiens	150-153
9923577-11	1998	CONCLUSIONS: Fluvoxamine is a fairly potent inhibitor of CYP2C19 and it has the potential for causing drug-drug interactions with substrates for CYP2C19 such as imipramine, clomipramine, amitriptyline and diazepam.	Diazepam	205-213	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	145-152
9685600-3	1998	In the CA3 area, extracellular glutamate started to increase soon after the KA injection and returned to the control level at about 1.5 h. A decrease and then slight increase of the extracellular glutamate level in CA3 followed the diazepam injection.	Diazepam	232-240	carbonic anhydrase 3	Rattus norvegicus	7-10
9685600-3	1998	In the CA3 area, extracellular glutamate started to increase soon after the KA injection and returned to the control level at about 1.5 h. A decrease and then slight increase of the extracellular glutamate level in CA3 followed the diazepam injection.	Diazepam	232-240	carbonic anhydrase 3	Rattus norvegicus	215-218
9633999-1	1998	The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene.	Diazepam	76-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	10-29
9712181-0	1998	Regulation of the action of the novel cholecystokinin-releasing peptide diazepam binding inhibitor by inhibitory hormones and taurocholate.	Diazepam	72-80	cholecystokinin	Rattus norvegicus	38-53
9591847-1	1998	The ability of diazepam, a benzodiazepine full agonist, and imidazenil, a benzodiazepine partial agonist, to protect hippocampal area CA1 neurons from death for at least 35 days after cerebral ischemia was investigated.	Diazepam	15-23	carbonic anhydrase 1	Homo sapiens	134-137
9591847-2	1998	Diazepam (10 mg/kg) administered to gerbils 30 and 90 minutes after forebrain ischemia produced significant protection of hippocampal area CA1 pyramidal neurons 7 days later.	Diazepam	0-8	carbonic anhydrase 1	Homo sapiens	139-142
9591847-16	1998	There was a significant, but weak, negative correlation between the degree of CA1 pyramidal cell survival and the number of working errors in both the diazepam and imidazenil groups.	Diazepam	151-159	carbonic anhydrase 1	Homo sapiens	78-81
9579292-0	1998	Pilot investigation of thyrotropin-releasing hormone-induced thyrotropin and prolactin release in anxious patients treated with diazepam.	Diazepam	128-136	thyrotropin releasing hormone	Homo sapiens	23-52
9610920-4	1998	These same 5-HT1A compounds, at subthreshold doses, produced an important reduction in burying behavior when combined with diazepam (0.25 mg/kg).	Diazepam	123-131	5-hydroxytryptamine receptor 1A	Rattus norvegicus	11-17
9582452-0	1998	Continuous treatment with nicotine increases diazepam binding inhibitor (DBI) and its mRNA in the mouse brain.	Diazepam	45-53	diazepam binding inhibitor	Mus musculus	73-76
9594523-6	1998	It is suggested that the memory disorder is the TGA due to various causes including transient hypertension, operative stress, postoperative pain and diazepam.	Diazepam	149-157	T-box transcription factor 1	Homo sapiens	48-51
9579292-0	1998	Pilot investigation of thyrotropin-releasing hormone-induced thyrotropin and prolactin release in anxious patients treated with diazepam.	Diazepam	128-136	prolactin	Homo sapiens	77-86
9579292-2	1998	The current study investigates basal and thyrotropin-releasing hormone (TRH)-stimulated TSH and PRL release in anxious patients treated with diazepam.	Diazepam	141-149	thyrotropin releasing hormone	Homo sapiens	41-70
9579292-2	1998	The current study investigates basal and thyrotropin-releasing hormone (TRH)-stimulated TSH and PRL release in anxious patients treated with diazepam.	Diazepam	141-149	thyrotropin releasing hormone	Homo sapiens	72-75
9521547-6	1998	Whilst diazepam produced a typical anxiolytic effect in intracranially-injected CSF rats, increasing open arm exploration, pentylenetetrazole displayed an opposite anxiogenic profile.	Diazepam	7-15	colony stimulating factor 2	Rattus norvegicus	80-83
9533812-5	1998	Diazepam binding inhibitor and luminal CCK-releasing factor are likely candidates for CCK-releasing peptides in the negative feedback process in the absence of pancreatic juice.	Diazepam	0-8	cholecystokinin	Homo sapiens	86-89
9576607-1	1998	Recently, an 86-amino acid polypeptide with high affinity for diazepam binding sites, termed diazepam-binding inhibitor (DBI), has been found in the rat brain.	Diazepam	62-70	diazepam binding inhibitor	Rattus norvegicus	93-119
9576607-1	1998	Recently, an 86-amino acid polypeptide with high affinity for diazepam binding sites, termed diazepam-binding inhibitor (DBI), has been found in the rat brain.	Diazepam	62-70	diazepam binding inhibitor	Rattus norvegicus	121-124
11672059-2	1998	Energy barriers for these translocation reactions of between 120.0 (1,7-iodine transfer) and 191.0 kJ mol(-)(1) (1,5-chlorine transfer) are predicted at the MP2/DZP level of theory; QCISD/DZP (single-point) calculations predict similar energy barriers.	Diazepam	161-164	tryptase pseudogene 1	Homo sapiens	157-160
11672059-2	1998	Energy barriers for these translocation reactions of between 120.0 (1,7-iodine transfer) and 191.0 kJ mol(-)(1) (1,5-chlorine transfer) are predicted at the MP2/DZP level of theory; QCISD/DZP (single-point) calculations predict similar energy barriers.	Diazepam	188-191	tryptase pseudogene 1	Homo sapiens	157-160
9543260-2	1998	The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats.	Diazepam	95-103	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	26-29
9543260-2	1998	The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats.	Diazepam	95-103	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	34-38
9543260-3	1998	Therefore, an increase in the NR1 and NR2B subunit proteins may be responsible for both the previously observed upregulation of [3H]dizocilpine binding in the cerebral cortex and the appearance of diazepam withdrawal signs.	Diazepam	197-205	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	30-33
9543260-3	1998	Therefore, an increase in the NR1 and NR2B subunit proteins may be responsible for both the previously observed upregulation of [3H]dizocilpine binding in the cerebral cortex and the appearance of diazepam withdrawal signs.	Diazepam	197-205	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	38-42
9570345-1	1998	We investigated the role of the mitochondrial diazepam binding inhibitor receptor (MDR) in diazepam-withdrawal seizure.	Diazepam	46-54	malic enzyme complex, mitochondrial	Mus musculus	83-86
9597158-17	1998	It is believed that the supersensitivity to kainic acid, convulsions and anxiety, and the increased expression of GLuR1, R2, and R3 may be parts of the mechanism of diazepam dependence.	Diazepam	165-173	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-119
9361326-1	1997	The abilities of the central (CBR) and the peripheral (PBR) benzodiazepine receptor antagonists, flumazenil (FLU) and PK 11195 (PK), to precipitate an abstinence syndrome in diazepam (DZ)-dependent rats have been evaluated.	Diazepam	174-182	translocator protein	Rattus norvegicus	55-58
9570345-8	1998	These findings suggest that the sensitivity of MDR-mediated pathways in the brain may be decreased during diazepam withdrawal.	Diazepam	106-114	malic enzyme complex, mitochondrial	Mus musculus	47-50
9435993-20	1997	CYP2C19 and CYP1A2, the metabolism of several benzodiazepines, including alprazolam, bromazepam and diazepam.	Diazepam	100-108	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
9435993-20	1997	CYP2C19 and CYP1A2, the metabolism of several benzodiazepines, including alprazolam, bromazepam and diazepam.	Diazepam	100-108	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	12-18
9435993-21	1997	Fluoxetine increases the plasma concentrations of alprazolam and diazepam by inhibiting CYP3A and CYP2C19, respectively.	Diazepam	65-73	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	98-105
9429229-4	1997	In adult liver preparations, the hydroxylation of diazepam correlated well with the CYP3 A content of microsomes (r = 0.858, p < 0.01) and with the 6 beta hydroxylation of testosterone (r = 0.830, p < 0.005), whereas demethylation was related to the bulk of CYP2C proteins (r = 0.865, p < 0.005).	Diazepam	50-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90
9429229-4	1997	In adult liver preparations, the hydroxylation of diazepam correlated well with the CYP3 A content of microsomes (r = 0.858, p < 0.01) and with the 6 beta hydroxylation of testosterone (r = 0.830, p < 0.005), whereas demethylation was related to the bulk of CYP2C proteins (r = 0.865, p < 0.005).	Diazepam	50-58	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	264-269
9404938-0	1997	Modulation of c-fos expression in the rat striatum by diazepam.	Diazepam	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
9404938-3	1997	Intraperitoneal administration of diazepam increased Fos protein levels in the striatum, but not in the hippocampus.	Diazepam	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-56
9404938-6	1997	The possible mechanisms underlying the modulatory effects of diazepam on c-fos expression in the brain are discussed.	Diazepam	61-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
9421826-0	1997	Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia.	Diazepam	12-20	carbonic anhydrase 1	Rattus norvegicus	52-55
9884116-10	1998	The anxiolytic agents diazepam (benzodiazepine), buspirone and ipsapirone (5-HT1A agonists) as well as ritanserin (5-HT2 antagonist) selectively impaired inhibitory avoidance while leaving one-way escape unchanged.	Diazepam	22-30	5-hydroxytryptamine receptor 1A	Rattus norvegicus	75-81
9401775-10	1997	The 5-HT4 receptor antagonists SDZ205-557, GR113808 and SB204070 caused dose-related reductions in the disinhibitory effect of diazepam, returning values to those shown in vehicle treated controls.	Diazepam	127-135	hypothermia due to alcohol sensitivity 4	Mus musculus	6-9
9276023-8	1997	Site specific human serum albumin (HSA) binding studies indicated a direct correlation between the ability of the compound to bind to the diazepam binding site (albumin site II) and the in vivo photosensitizing efficacy.	Diazepam	138-146	albumin	Mus musculus	20-33
9288408-9	1997	This revealed that the P300 was reduced in the 250-574 ms window in the diazepam group.	Diazepam	72-80	E1A binding protein p300	Homo sapiens	23-27
9385589-3	1997	Long-term treatment of mice with full allosteric modulator (triazolam 0.25 mg/kg/day for 8 days) or selective allosteric modulator (diazepam 20 mg/kg/day for 21 days) of GABAA receptor induced tolerance to behavioral sedation on actimeter and anxiolytic effects on plus-maze, and produced a marked withdrawal anxiety and hyperactivity syndrome upon abrupt cessation of treatment, respectively.	Diazepam	132-140	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	170-175
9263374-2	1997	However, no study has examined the relationship between the metabolism of triazolam and CYP2C19, which is involved in the metabolism of diazepam.	Diazepam	136-144	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	88-95
16414799-0	1997	Effect of dextran 70 blood substitute on diazepam binding by human serum albumin.	Diazepam	41-49	albumin	Homo sapiens	67-80
16414799-1	1997	Diazepam binding studies with dextran 70 and human serum albumin (HSA) were carried out using centrifugation and a membrane ultrafiltration technique to separate the drug protein complex and the free microsolute.	Diazepam	0-8	albumin	Homo sapiens	51-64
9145922-2	1997	To gain further insight into the mechanism of action of BZs on GABA receptors, we have been investigating structural determinants required for the actions of the BZ diazepam (dzp) on recombinant alpha1 beta2 gamma2 GABA(A) receptors.	Diazepam	165-173	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	202-207
9219899-6	1997	In binding studies we have characterized binding sites on microsomal membranes for the ACAT substrate oleoyl-CoA and the ACAT inhibitor diazepam.	Diazepam	136-144	sterol O-acyltransferase 1	Homo sapiens	87-91
9219899-6	1997	In binding studies we have characterized binding sites on microsomal membranes for the ACAT substrate oleoyl-CoA and the ACAT inhibitor diazepam.	Diazepam	136-144	sterol O-acyltransferase 1	Homo sapiens	121-125
9145922-2	1997	To gain further insight into the mechanism of action of BZs on GABA receptors, we have been investigating structural determinants required for the actions of the BZ diazepam (dzp) on recombinant alpha1 beta2 gamma2 GABA(A) receptors.	Diazepam	175-178	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	202-207
9128832-0	1997	Effects of chronic diazepam treatment on pre- and postsynaptic 5-HT1A receptors in the rat brain.	Diazepam	19-27	5-hydroxytryptamine receptor 1A	Rattus norvegicus	63-69
9042784-1	1997	The diazepam-binding inhibitor (DBI) was originally isolated as an endogenous competitor of diazepam for mammalian central nervous system binding sites.	Diazepam	4-12	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	32-35
9140695-10	1997	On the other hand, the increase in c-fos mRNA produced by the stress of the injection was inhibited in the cerebral cortex by diazepam or propranolol and in the hippocampus only by diazepam.	Diazepam	126-134	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
9140695-10	1997	On the other hand, the increase in c-fos mRNA produced by the stress of the injection was inhibited in the cerebral cortex by diazepam or propranolol and in the hippocampus only by diazepam.	Diazepam	181-189	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
9113346-4	1997	Each stereoisomer of troglitazone displaced dansylsarcosine, a typical specific fluorescent probe for the diazepam binding site on human serum albumin (HSA).	Diazepam	106-114	albumin	Mus musculus	137-150
9027410-0	1997	Amphetamine-induced preprodynorphin mRNA expression and kappa-opioid receptor binding in basal ganglia of adult rats after prenatal exposure to diazepam.	Diazepam	144-152	prodynorphin	Rattus norvegicus	20-35
9137871-5	1997	We speculate that the ALS originates in the midline structures, spreading bilaterally and synchronously to the "dysfunctional" cortex; the sustained discharges were a manifestation of associated reticular lesions, and we believe that intravenous diazepam suppressed the spread of ALS to the "dysfunctional cortex," leading to the appearance of the suppression-burst pattern.	Diazepam	246-254	superoxide dismutase 1	Homo sapiens	22-25
9137871-5	1997	We speculate that the ALS originates in the midline structures, spreading bilaterally and synchronously to the "dysfunctional" cortex; the sustained discharges were a manifestation of associated reticular lesions, and we believe that intravenous diazepam suppressed the spread of ALS to the "dysfunctional cortex," leading to the appearance of the suppression-burst pattern.	Diazepam	246-254	superoxide dismutase 1	Homo sapiens	280-283
9073163-9	1997	Pretreatment with diazepam blocked the seizures as well as the elevation of BDNF mRNA.	Diazepam	18-26	brain-derived neurotrophic factor	Rattus norvegicus	76-80
9029042-6	1997	At a substrate concentration of 10 microM, diazepam N-demethylation in a panel of human liver microsomes was inhibited 42 +/- 12% (mean +/- SD, N = 6) by a polyclonal anti-CYP2C antibody.	Diazepam	43-51	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	172-177
9015987-4	1996	Most PRN medication was given orally and the most frequently administered drugs were procyclidine, lorazepam, ibuprofen, diazepam and droperidol.	Diazepam	121-129	cytosolic iron-sulfur assembly component 3	Homo sapiens	5-8
9022045-1	1997	The diazepam binding inhibitor [DBI, also known as acyl-CoA-binding protein, (ACBP), or endozepine] is a 10-kD protein that has been suggested to be involved in the regulation of several biological processes such as acyl-CoA metabolism, steroidogenesis, insulin secretion, and gamma-aminobutyric acid type A (GABA(A))/benzodiazepine receptor modulation.	Diazepam	4-12	diazepam binding inhibitor	Rattus norvegicus	32-35
9022045-1	1997	The diazepam binding inhibitor [DBI, also known as acyl-CoA-binding protein, (ACBP), or endozepine] is a 10-kD protein that has been suggested to be involved in the regulation of several biological processes such as acyl-CoA metabolism, steroidogenesis, insulin secretion, and gamma-aminobutyric acid type A (GABA(A))/benzodiazepine receptor modulation.	Diazepam	4-12	diazepam binding inhibitor	Rattus norvegicus	78-82
9022045-1	1997	The diazepam binding inhibitor [DBI, also known as acyl-CoA-binding protein, (ACBP), or endozepine] is a 10-kD protein that has been suggested to be involved in the regulation of several biological processes such as acyl-CoA metabolism, steroidogenesis, insulin secretion, and gamma-aminobutyric acid type A (GABA(A))/benzodiazepine receptor modulation.	Diazepam	4-12	diazepam binding inhibitor	Rattus norvegicus	88-98
9042377-1	1997	beta-carboline-3-carboxylate-t-butyl ester (beta CCT) is the most selective antagonist for the alpha 1 beta 2 gamma 2 benzodiazepine (BZ) receptor subtype which blocks anticonvulsant and antipunishment (anxiolytic) but not sedative and myorelaxant effects of diazepam.	Diazepam	259-267	t-complex protein 1	Mus musculus	49-52
9029710-4	1997	We also showed that the polypeptide diazepam binding inhibitor (DBI), an endogenous PBR ligand, stimulates cholesterol transport and promotes loading of cholesterol to P450scc in vitro, and that its presence is vital for hCG-induced steroidogenesis by Leydig cells.	Diazepam	36-44	translocator protein	Homo sapiens	84-87
9029710-4	1997	We also showed that the polypeptide diazepam binding inhibitor (DBI), an endogenous PBR ligand, stimulates cholesterol transport and promotes loading of cholesterol to P450scc in vitro, and that its presence is vital for hCG-induced steroidogenesis by Leydig cells.	Diazepam	36-44	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	168-175
8948091-2	1996	We have examined the metabolism of diazepam by ten human cytochrome P450 forms (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4 and 3A5) expressed in HepG2 cells using a recombinant vaccinia virus system.	Diazepam	35-43	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
8922750-15	1996	Sev, like pentobarbitone (PB), pregnanolone (PGN) or diazepam (DZP), potentiated the 10(-6) M GABA-induced response without shifting the reversal potential of IGABA.	Diazepam	53-61	kallikrein 1-related peptidase C9	Rattus norvegicus	0-3
8922750-15	1996	Sev, like pentobarbitone (PB), pregnanolone (PGN) or diazepam (DZP), potentiated the 10(-6) M GABA-induced response without shifting the reversal potential of IGABA.	Diazepam	63-66	kallikrein 1-related peptidase C9	Rattus norvegicus	0-3
8922750-17	1996	ISev was augmented by PB, PGN, or DZP at concentrations that maximally potentiated IGABA, suggesting that Sev enhanced IGABA at a binding site distinct from that for PB, PGN, or DZP.	Diazepam	34-37	kallikrein 1-related peptidase C9	Rattus norvegicus	1-4
8948091-2	1996	We have examined the metabolism of diazepam by ten human cytochrome P450 forms (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4 and 3A5) expressed in HepG2 cells using a recombinant vaccinia virus system.	Diazepam	35-43	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	80-86
8948091-4	1996	Among the P450 forms tested, diazepam was significantly demethylated by CYP2B6, 2C9, 2C19, 3A4 and 3A5, with 2C19 exhibiting the highest rate at concentrations < 0.1 mM, and hydroxylated only by the latter three enzymes, with 3A5 being the most active.	Diazepam	29-37	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	10-14
8948091-4	1996	Among the P450 forms tested, diazepam was significantly demethylated by CYP2B6, 2C9, 2C19, 3A4 and 3A5, with 2C19 exhibiting the highest rate at concentrations < 0.1 mM, and hydroxylated only by the latter three enzymes, with 3A5 being the most active.	Diazepam	29-37	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	72-78
8948091-13	1996	Our results suggest that in the human liver, the metabolism of diazepam to nordiazepam is mediated by CYP3A4, which has been reported as the most abundant P450 form in human liver as well as 2C19, which has been reported as a polymorphic enzyme.	Diazepam	63-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	102-108
8948091-13	1996	Our results suggest that in the human liver, the metabolism of diazepam to nordiazepam is mediated by CYP3A4, which has been reported as the most abundant P450 form in human liver as well as 2C19, which has been reported as a polymorphic enzyme.	Diazepam	63-71	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	155-159
8819520-13	1996	Other agents were less effective, which suggested a possible role for the diazepam-insensitive GABA-A sites that are recognized by Ro15-4513.	Diazepam	74-82	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	95-101
8873559-0	1996	Halothane and diazepam inhibit ketamine-induced c-fos expression in the rat cingulate cortex.	Diazepam	14-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
8873559-4	1996	METHODS: The effects of diazepam and halothane on c-Fos expression induced by ketamine were studied.	Diazepam	24-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-55
8873559-10	1996	Diazepam suppressed the ketamine-induced c-Fos-like immunoreactivity in the cingulate and retrosplenial cortices in a dose-dependent manner, leaving the thalamus and neocortex less affected.	Diazepam	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-46
8873559-12	1996	CONCLUSION: Halothane and diazepam inhibited ketamine-induced c-Fos expression in the cingulate and retrosplenial cortices, leaving the thalamus relatively unaffected.	Diazepam	26-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
8904619-11	1996	These results are compatible with the conclusion that both diazepam and desmethyldiazepam are metabolized by cytochrome P450 CYP2C19 in the Chinese population.	Diazepam	59-67	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	125-132
8930576-4	1996	The substrates and inhibitors of CYP2C19 and CYP3A4 and the known genetic polymorphism of CYP2C19 explain some but not all of the interactions of lansoprazole, and particularly the interactions of omeprazole with carbamazepine, diazepam, phenytoin and theophylline or caffeine.	Diazepam	228-236	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	33-40
8930576-4	1996	The substrates and inhibitors of CYP2C19 and CYP3A4 and the known genetic polymorphism of CYP2C19 explain some but not all of the interactions of lansoprazole, and particularly the interactions of omeprazole with carbamazepine, diazepam, phenytoin and theophylline or caffeine.	Diazepam	228-236	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51
8930576-4	1996	The substrates and inhibitors of CYP2C19 and CYP3A4 and the known genetic polymorphism of CYP2C19 explain some but not all of the interactions of lansoprazole, and particularly the interactions of omeprazole with carbamazepine, diazepam, phenytoin and theophylline or caffeine.	Diazepam	228-236	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	90-97
8923565-7	1996	The elevation in plasma concentrations of zotepine after coadministration of diazepam may be a result of competitive inhibition of zotepine metabolism by diazepam via other isoenzyme than CYP2C19, e.g., CYP3A4.	Diazepam	77-85	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	188-195
8923565-7	1996	The elevation in plasma concentrations of zotepine after coadministration of diazepam may be a result of competitive inhibition of zotepine metabolism by diazepam via other isoenzyme than CYP2C19, e.g., CYP3A4.	Diazepam	77-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	203-209
8819520-14	1996	The failure of diazepam to suppress NK activity also suggests that increased chloride flux through diazepam-sensitive GABA-A receptors (which is caused by EtOH as well as diazepam) does not mediate NK suppression in this model.	Diazepam	99-107	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	118-124
8819520-14	1996	The failure of diazepam to suppress NK activity also suggests that increased chloride flux through diazepam-sensitive GABA-A receptors (which is caused by EtOH as well as diazepam) does not mediate NK suppression in this model.	Diazepam	99-107	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	118-124
8780034-0	1996	Stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat: prevention by diazepam but not ondansetron.	Diazepam	119-127	cholecystokinin	Rattus norvegicus	41-56
8700104-6	1996	alpha 5 beta 3 gamma 2L receptors were zinc and diazepam sensitive but zolpidem insensitive.	Diazepam	48-56	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	8-14
8819299-4	1996	Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazepam were form-selective substrates towards CYP2A6, the CYP1A subfamily, CYP2B6, the CYP2C subfamily, CYP2E1 and the CYP3A subfamily respectively.	Diazepam	76-84	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	124-130
8819299-4	1996	Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazepam were form-selective substrates towards CYP2A6, the CYP1A subfamily, CYP2B6, the CYP2C subfamily, CYP2E1 and the CYP3A subfamily respectively.	Diazepam	76-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	153-159
8819299-4	1996	Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazepam were form-selective substrates towards CYP2A6, the CYP1A subfamily, CYP2B6, the CYP2C subfamily, CYP2E1 and the CYP3A subfamily respectively.	Diazepam	76-84	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	182-188
8873112-0	1996	Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH) and diazepam-binding inhibitor (DBI) during alcohol withdrawal and abstinence.	Diazepam	80-88	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	108-111
8873112-1	1996	The neuropeptides diazepam binding inhibitor (DBI) and corticotropin-releasing hormone (CRH) elicit anxietylike symptoms when administered intracerebroventricularly to laboratory animals.	Diazepam	18-26	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	46-49
8886934-3	1996	Diazepam but not majonoside-R2 exhibited a protective activity against convulsion caused by the GABAA antagonists bicuculline and picrotoxin.	Diazepam	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	96-101
8886934-4	1996	These results indicate that GABAA systems are involved in the effect of majonoside-R2 on the opioid-induced antinociception and suggest that the mechanisms of action of majonoside-R2 may differ from those of diazepam.	Diazepam	208-216	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	28-33
8755579-8	1996	Similarly, diazepam binding inhibitor33-52 [corrected] also stimulated CCK release and pancreatic secretion in a dose-dependent manner although it was 100 times less potent than the whole peptide.	Diazepam	11-19	cholecystokinin	Rattus norvegicus	71-74
8903430-5	1996	This confirms diazepam C3-hydroxylase as a useful and easily measured index of CYP3A monooxygenase content in female rat liver microsomes.	Diazepam	14-22	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	79-84
8905790-9	1996	As a plausible explanation for this, the metabolism of zotepine and diazepam may be commonly mediated not by CYP2C19 but by cytochrome P450 3A4, and the pharmacokinetic interactions may result from competitive inhibition between these two drugs.	Diazepam	68-76	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	109-116
8728564-6	1996	Diazepam alone increased Fos IS in PVN and in SON as well as in ACe.	Diazepam	0-8	angiotensin I converting enzyme	Rattus norvegicus	64-67
8728564-7	1996	In diazepam- and nicotine-treated rats Fos IS was increased in PVN and SON as well as in MT and i.p..	Diazepam	3-11	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-42
8728564-9	1996	of diazepam and nicotine-treated rats Fos IS was similar to that induced by nicotine alone, and in PVN and SON of these rats Fos IS in ACe.	Diazepam	3-11	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-41
8728564-10	1996	Taken together, diazepam induced Fos IS in all stress-related areas studied (PVN, SON, ACe), but not in central visual structures, where nicotine induces Fos IS (MT, i.p.).	Diazepam	16-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-36
8728564-10	1996	Taken together, diazepam induced Fos IS in all stress-related areas studied (PVN, SON, ACe), but not in central visual structures, where nicotine induces Fos IS (MT, i.p.).	Diazepam	16-24	angiotensin I converting enzyme	Rattus norvegicus	87-90
8728564-10	1996	Taken together, diazepam induced Fos IS in all stress-related areas studied (PVN, SON, ACe), but not in central visual structures, where nicotine induces Fos IS (MT, i.p.).	Diazepam	16-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	154-157
8728564-0	1996	Expression of Fos protein in various rat brain areas following acute nicotine and diazepam.	Diazepam	82-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
8728564-6	1996	Diazepam alone increased Fos IS in PVN and in SON as well as in ACe.	Diazepam	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-28
8905790-9	1996	As a plausible explanation for this, the metabolism of zotepine and diazepam may be commonly mediated not by CYP2C19 but by cytochrome P450 3A4, and the pharmacokinetic interactions may result from competitive inhibition between these two drugs.	Diazepam	68-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-143
17451291-9	1996	These results suggest that malaria infection and fever have no effect on the activities of the CYP3A isozymes thought to be involved in the metabolism of diazepam and ethosuximide.	Diazepam	154-162	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	95-100
8624588-0	1996	[The effect of diazepam and flumazenil on pulsatile secretion of prolactin and LH in women].	Diazepam	15-23	prolactin	Homo sapiens	65-74
8624588-7	1996	Diazepam caused in 3 of 4 women in the luteal phase of the cycle a significant rise of the prolactin secretion (p < 0.001), in the remaining women in the luteal phase and 3 women in the follicular stage a rise of prolactin was recorded but it did not reach statistical significance.	Diazepam	0-8	prolactin	Homo sapiens	91-100
8624588-7	1996	Diazepam caused in 3 of 4 women in the luteal phase of the cycle a significant rise of the prolactin secretion (p < 0.001), in the remaining women in the luteal phase and 3 women in the follicular stage a rise of prolactin was recorded but it did not reach statistical significance.	Diazepam	0-8	prolactin	Homo sapiens	216-225
8706205-5	1995	[3H]-diazepam radioligand binding assays demonstrated that the number of receptors in the septic rats was increased in the forebrain (CLP rats; 2.37 +/- 0.04 pmol x mg(-1) protein, control rats; 1.45 +/- 0.02 pmol x mg(-1) protein, sham-operated rats; 1.49 +/- 0.03 pmol x mg(-1) protein), cerebellum (CLP rats; 1.55 +/- 0.05 pmol x mg(-1) protein, control rats; 1.05 +/- 0.02 pmol x mg(-1) protein, sham-operated rats: 1.09 +/- 0.02 pmol x mg(-1) protein) and brain stem (CLP rats; 1.21 +/- 0.04 pmol x mg(-1) protein, control rats; 0.61 +/- 0.02 pmol x mg(-1) protein, sham-operated rats; 0.63 +/- 0.02 pmol x mg(-1) protein) compared with the control and sham-operated rats (P< 0.05).	Diazepam	5-13	coactosin-like F-actin binding protein 1	Rattus norvegicus	134-137
8592140-6	1996	The alpha 1 subunit contributes the high-affinity binding of [3H]Ro 15-1788 (flumazenil) and the diazepam-sensitive binding of [3H]Ro 15-4513.	Diazepam	97-105	adrenoceptor alpha 1D	Homo sapiens	4-11
9328629-3	1996	Also the potentiation of the anticonvulsive effect of diazepam, phenobarbital and valproic acid (VPA) was observed in BCCA and AOAA (CD97, 150 mg/kg) treated animals.	Diazepam	54-62	adhesion G protein-coupled receptor E5	Mus musculus	133-137
8540894-4	1995	The best probabilities of linkage were found between the variables characterizing response to diazepam and loci on chromosomes 1 (Xmv-41) and 10 (D10Mit2) and between the sensitivity to the convulsant actions of beta-CCM and locus D15Mit5 on chromosome 15.	Diazepam	94-102	xenotropic murine leukemia virus 41	Mus musculus	130-136
9014155-8	1996	These findings and analysis by computer modeling indicated that diazepam likely enhances GABA receptor currents primarily by accelerating GABA association to its receptor at the first agonist binding site.	Diazepam	64-72	GABA type A receptor-associated protein	Homo sapiens	89-102
9014161-3	1996	This study investigates the effects of chronic diazepam and abecarnil treatment on expression of GABAA receptor alpha 1-6 beta 1-3 and gamma 1-3 subunit isoform mRNAs in rat cortex.	Diazepam	47-55	crystallin, gamma E	Rattus norvegicus	135-144
9014161-7	1996	Gamma 2-Subunit mRNA was significantly decreased after 14 days of either diazepam or abecarnil exposure.	Diazepam	73-81	crystallin, gamma E	Rattus norvegicus	0-7
7485498-2	1995	In this study, cholescintigraphy (under ketamine and diazepam anesthesia) was used to determine gallbladder emptying rate and ejection fraction in response to cholecystokinin (CCK) in eight male and six female prairie dogs fed a nonlithogenic diet.	Diazepam	53-61	cholecystokinin	Canis lupus familiaris	176-179
7675878-3	1995	In addition, pretreatment with ICV injection of histamine H3-receptor antagonist, thioperamide, and histamine H3-receptor agonist, (R) alpha methylhistamine, enhanced and inhibited diazepam-induced hyperphagia (1 mg/kg, SC) in nondeprived rats, respectively.	Diazepam	181-189	histamine receptor H3	Rattus norvegicus	48-69
8519435-2	1995	When ALDH activity assays were carried out spectrophotometrically on a hemoglobin-free lysate of human erythrocytes with propionaldehyde as substrate, addition of diazepam (10 mumol/l) did not affect the enzyme activity.	Diazepam	163-171	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	5-9
8519435-5	1995	Diazepam inhibited the rat liver mitochondrial low Km ALDH activity by about 50%.	Diazepam	0-8	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	54-58
8521680-9	1995	While CYP2D6 catalyses the metabolism of lipophilic bases only, CYP2C19 is involved in the metabolism of acids (e.g. S-mephenytoin), bases (e.g. imipramine and omeprazole) and neutral drugs (e.g. diazepam).	Diazepam	196-204	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	6-12
8521680-9	1995	While CYP2D6 catalyses the metabolism of lipophilic bases only, CYP2C19 is involved in the metabolism of acids (e.g. S-mephenytoin), bases (e.g. imipramine and omeprazole) and neutral drugs (e.g. diazepam).	Diazepam	196-204	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	64-71
8521680-13	1995	Diazepam is partially demethylated by CYP2C19, and the high frequency of mutated alleles in Orientals is probably the reason why such populations have a slower metabolism and are treated with lower doses of diazepam than Caucasians.	Diazepam	0-8	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	38-45
8528572-4	1995	In tubocurarine (0.6-0.8 microM)-partially paralyzed preparations, diazepam (35 microM) and Ro 5-4864 (3-30 microM), a peripheral type benzodiazepine receptor agonist, potentiated the inhibitory effect of adenosine on indirect twitch responses.	Diazepam	67-75	translocator protein	Mus musculus	119-158
7675878-3	1995	In addition, pretreatment with ICV injection of histamine H3-receptor antagonist, thioperamide, and histamine H3-receptor agonist, (R) alpha methylhistamine, enhanced and inhibited diazepam-induced hyperphagia (1 mg/kg, SC) in nondeprived rats, respectively.	Diazepam	181-189	histamine receptor H3	Rattus norvegicus	100-121
7675878-6	1995	Furthermore, enhancement or inhibition of diazepam-induced hyperphagia by histamine H3-receptor antagonist or agonist may occur via histamine H3-receptors localized in the other neurons in the rat brain.	Diazepam	42-50	histamine receptor H3	Rattus norvegicus	74-95
7628184-1	1995	OBJECTIVES: To compare the effect of omeprazole, a substrate and inhibitor of CYP2C19, on diazepam metabolism in white and Chinese subjects.	Diazepam	90-98	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	78-85
7556974-4	1995	Tritiated glyburide, C14 albumin or C14-labelled diazepam were injected into 13, 9 and 11 pregnant rats, respectively and the radioactivity was measured thereafter in maternal blood and in whole fetal extracts.	Diazepam	49-57	anti-Mullerian hormone receptor type 2	Rattus norvegicus	36-39
7550130-1	1995	Possible involvement of the peripheral-type benzodiazepine receptor (PBR) in hemin/protoporphyrin-induced erythroid differentiation of human leukemia K562 cells was investigated by the use of the ligands, diazepam and PK11195.	Diazepam	205-213	translocator protein	Homo sapiens	69-72
7670003-2	1995	Recently, an 86-amino acid polypeptide with high affinity for diazepam binding sites, termed diazepam-binding inhibitor (DBI), has been found in the rat brain.	Diazepam	62-70	diazepam binding inhibitor	Rattus norvegicus	93-119
7670003-2	1995	Recently, an 86-amino acid polypeptide with high affinity for diazepam binding sites, termed diazepam-binding inhibitor (DBI), has been found in the rat brain.	Diazepam	62-70	diazepam binding inhibitor	Rattus norvegicus	121-124
7550130-3	1995	The PBR-specific antagonist, PK11195, dose-dependently inhibited both diazepam-induced and hemin/protoporphyrin-induced K562 cell differentiation.	Diazepam	70-78	translocator protein	Homo sapiens	4-7
7542903-7	1995	The naturally occurring diazepam-binding inhibitor stimulates in vivo steroidogenesis via binding to PBR.	Diazepam	24-32	translocator protein	Homo sapiens	101-104
7544471-1	1995	Diazepam binding inhibitor (DBI1-86) is a peptide that is present in large amounts in the intestine and pancreas and which inhibits glucose-stimulated insulin release from both perfused pancreas and isolated islets in low nanomolar concentrations.	Diazepam	0-8	insulin	Mesocricetus auratus	151-158
7626442-3	1995	We demonstrated that a key element in the regulation of cholesterol transport is the mitochondrial peripheral-type benzodiazepine receptor (PBR) and that the presence of the polypeptide diazepam binding inhibitor (DBI) was vital for steroidogenesis.	Diazepam	186-194	translocator protein	Homo sapiens	140-143
7626442-3	1995	We demonstrated that a key element in the regulation of cholesterol transport is the mitochondrial peripheral-type benzodiazepine receptor (PBR) and that the presence of the polypeptide diazepam binding inhibitor (DBI) was vital for steroidogenesis.	Diazepam	186-194	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	214-217
8562316-3	1995	Moreover, after bicuculline treatment we observed an earlier increase of trkC mRNA level, which peaked after 3 h and returned back to normal levels by 12 h. In contrast, the kainic acid treatment produced a delayed increase of trkC mRNA, which initiated after 6 h, peaked at 12 h, and returned to normal levels at 24 h. This increase, which involves also trkC mRNA receptor with tyrosine kinase activity, was mediated by non-NMDA receptors and counteracted by GABA potentiating agent diazepam.	Diazepam	484-492	neurotrophic receptor tyrosine kinase 3	Rattus norvegicus	73-77
7779243-4	1995	Compared with untreated patients, alprazolam-treated patients displayed significantly less diazepam-induced change in peak saccadic velocity, saccade latency, growth hormone secretion, memory, and self-rated levels of sedation.	Diazepam	91-99	growth hormone 1	Homo sapiens	159-173
8806399-5	1995	The remaining interactions (felbamate, omeprazole, cimetidine, fluoxetine, imipramine, and diazepam) were attributed to inhibition of CYP2C19.	Diazepam	91-99	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	134-141
7566474-4	1995	At normal therapeutic concentrations, diazepam, carbamazepine and phenobarbital occupy respectively 70, 30 and 10% of PBR sites in human lymphocytes.	Diazepam	38-46	translocator protein	Homo sapiens	118-121
7796139-2	1995	It was found that diazepam inhibited the ability of basic fibroblast growth factor (bFGF) to stimulate [3H]thymidine incorporation; the IC50 was approximately 5 microM.	Diazepam	18-26	fibroblast growth factor 2	Rattus norvegicus	52-82
7796139-2	1995	It was found that diazepam inhibited the ability of basic fibroblast growth factor (bFGF) to stimulate [3H]thymidine incorporation; the IC50 was approximately 5 microM.	Diazepam	18-26	fibroblast growth factor 2	Rattus norvegicus	84-88
7796139-5	1995	In addition, diazepam reduced the stimulation of DNA synthesis caused by epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), polypeptide growth factors coupled to receptor tyrosine kinases, as well as thrombin, an activator of G protein-coupled receptors.	Diazepam	13-21	myotrophin	Rattus norvegicus	83-96
7796139-5	1995	In addition, diazepam reduced the stimulation of DNA synthesis caused by epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), polypeptide growth factors coupled to receptor tyrosine kinases, as well as thrombin, an activator of G protein-coupled receptors.	Diazepam	13-21	myotrophin	Rattus norvegicus	124-137
7796139-5	1995	In addition, diazepam reduced the stimulation of DNA synthesis caused by epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), polypeptide growth factors coupled to receptor tyrosine kinases, as well as thrombin, an activator of G protein-coupled receptors.	Diazepam	13-21	coagulation factor II	Rattus norvegicus	222-230
7883264-3	1995	Phenytoin, ketoconazole, and cyproterone acetat modify the secretion of cortisol; opiates and diazepam inhibit that of ACTH.	Diazepam	94-102	proopiomelanocortin	Homo sapiens	119-123
7895812-5	1995	Likewise, DZP induced marked decreases (19-45%) in LCMRglcs in most structures studied at P10, P14, and P21.	Diazepam	10-13	S100 calcium binding protein A9	Rattus norvegicus	95-98
7895812-5	1995	Likewise, DZP induced marked decreases (19-45%) in LCMRglcs in most structures studied at P10, P14, and P21.	Diazepam	10-13	KRAS proto-oncogene, GTPase	Rattus norvegicus	104-107
7823161-9	1995	In addition, diazepam prevented the loss of 35S-TBPS binding sites in the striatum and in the dendritic fields of the CA1 hippocampus following ischemia.	Diazepam	13-21	carbonic anhydrase 1	Rattus norvegicus	118-121
8562316-3	1995	Moreover, after bicuculline treatment we observed an earlier increase of trkC mRNA level, which peaked after 3 h and returned back to normal levels by 12 h. In contrast, the kainic acid treatment produced a delayed increase of trkC mRNA, which initiated after 6 h, peaked at 12 h, and returned to normal levels at 24 h. This increase, which involves also trkC mRNA receptor with tyrosine kinase activity, was mediated by non-NMDA receptors and counteracted by GABA potentiating agent diazepam.	Diazepam	484-492	neurotrophic receptor tyrosine kinase 3	Rattus norvegicus	227-231
7823161-11	1995	Diazepam was microinjected into the CA1 hippocampus 1 and 2 hr following ischemia, and rats remained normothermic.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	36-39
7823174-9	1995	Diazepam also produced dose-related decreases in conditioned stress-induced c-fos expression in all but one structure, the effects being statistically significant in 38 of 60 sampled structures.	Diazepam	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-81
7823174-10	1995	Diazepam dose dependently increased fear-induced c-fos expression in the central nucleus of the amygdala.	Diazepam	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
7823174-13	1995	The extent to which diazepam decreased conditioned stress-induced c-fos expression was unrelated to previous estimates of benzodiazepine receptor density in the sampled structures.	Diazepam	20-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-71
8562316-3	1995	Moreover, after bicuculline treatment we observed an earlier increase of trkC mRNA level, which peaked after 3 h and returned back to normal levels by 12 h. In contrast, the kainic acid treatment produced a delayed increase of trkC mRNA, which initiated after 6 h, peaked at 12 h, and returned to normal levels at 24 h. This increase, which involves also trkC mRNA receptor with tyrosine kinase activity, was mediated by non-NMDA receptors and counteracted by GABA potentiating agent diazepam.	Diazepam	484-492	neurotrophic receptor tyrosine kinase 3	Rattus norvegicus	227-231
7704038-1	1994	Metabolism of diazepam was studied in vitro to identify the forms of cytochrome P450 (CYP) responsible for N-demethylation (nordazepam formation) and 3-hydroxylation (temazepam formation), using liver microsomes obtained from extensive (EM) and poor metabolizers (PM) for S-mephenytoin 4"-hydroxylation.	Diazepam	14-22	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-84
7658920-3	1995	Both diazepam and clonazepam pre-treatment reversed the effects of noise on CBR binding, confirming a role of these receptors in the response to noise stress.	Diazepam	5-13	cannabinoid receptor 1	Rattus norvegicus	76-79
7888293-16	1994	A decrease of arousal could be found in the alpha 2-range, whereas in the beta 2 and the theta-range the power density increased under diazepam.	Diazepam	135-143	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	74-80
7711467-8	1994	FD subjects treated with fludrocortisone, had elevated supine and erect noradrenaline (p < 0.05 and p = 0.06); and those on diazepam had lower erect and post exercise noradrenaline (p < 0.05), but ANP levels were similar.	Diazepam	124-132	natriuretic peptide A	Homo sapiens	197-200
8841564-5	1995	Its activity for the ApA hydrolysis is 100-fold greater than that of free La(III) ion.	Diazepam	74-81	glutamyl aminopeptidase	Homo sapiens	21-24
7550425-1	1994	Diazepam increased the carboxypeptidase H activity and decreased the angiotensin converting enzyme activity in the rat brain.	Diazepam	0-8	carboxypeptidase E	Rattus norvegicus	23-41
7550425-2	1994	Joint action of diazepam and emotional stress changed the carboxypeptidase H activity to the least extent and the angiotensin converting enzyme activity to the utmost extent as compared to the agents" separate effects.	Diazepam	16-24	carboxypeptidase E	Rattus norvegicus	58-76
7704038-1	1994	Metabolism of diazepam was studied in vitro to identify the forms of cytochrome P450 (CYP) responsible for N-demethylation (nordazepam formation) and 3-hydroxylation (temazepam formation), using liver microsomes obtained from extensive (EM) and poor metabolizers (PM) for S-mephenytoin 4"-hydroxylation.	Diazepam	14-22	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	86-89
7704038-5	1994	An antibody raised against CYP2C9 (anti-human CYP2C) strongly inhibited diazepam N-demethylation in EM liver microsomes at a low substrate concentration (20 microM).	Diazepam	72-80	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	27-33
7704038-5	1994	An antibody raised against CYP2C9 (anti-human CYP2C) strongly inhibited diazepam N-demethylation in EM liver microsomes at a low substrate concentration (20 microM).	Diazepam	72-80	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	27-32
7898662-6	1994	Administration of diazepam blocked the kainate-induced seizures and prevented DNA fragmentation in CA3 but not in the amygdala.	Diazepam	18-26	carbonic anhydrase 3	Homo sapiens	99-102
7965056-5	1994	Like the rho 1 subunit, the currents generated by rho 2 are insensitive to GABAA receptor modulators including bicuculline, hexobarbital, and diazepam and can be reversibly inhibited by ZnCl2.	Diazepam	142-150	gamma-aminobutyric acid type A receptor subunit rho2	Homo sapiens	50-55
7929453-9	1994	Thus, the subunit combinations alpha 1 beta 2 gamma 2 and alpha 2 beta 3 gamma 2 represent two main GABAA receptor subtypes, which together amount to 75-85% of the diazepam-sensitive GABAA receptors.	Diazepam	164-172	adrenoceptor alpha 1D	Homo sapiens	31-38
7929453-9	1994	Thus, the subunit combinations alpha 1 beta 2 gamma 2 and alpha 2 beta 3 gamma 2 represent two main GABAA receptor subtypes, which together amount to 75-85% of the diazepam-sensitive GABAA receptors.	Diazepam	164-172	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-45
7929453-9	1994	Thus, the subunit combinations alpha 1 beta 2 gamma 2 and alpha 2 beta 3 gamma 2 represent two main GABAA receptor subtypes, which together amount to 75-85% of the diazepam-sensitive GABAA receptors.	Diazepam	164-172	tryptophanyl-tRNA synthetase 1	Homo sapiens	46-53
7929453-9	1994	Thus, the subunit combinations alpha 1 beta 2 gamma 2 and alpha 2 beta 3 gamma 2 represent two main GABAA receptor subtypes, which together amount to 75-85% of the diazepam-sensitive GABAA receptors.	Diazepam	164-172	tryptophanyl-tRNA synthetase 1	Homo sapiens	73-80
7845588-3	1994	Several neurotransmitter receptor antagonists inhibited induction of HSP70 produced by phencyclidine (50 mg/kg): haloperidol (ED50 = 0.8 mg/kg), clozapine (ED50 = 1 mg/kg), valium (ED50 = 1 mg/kg), SCH 23390 (ED50 = 7 mg/kg) and muscimol (ED50 = 3 mg/kg).	Diazepam	173-179	heat shock protein family A (Hsp70) member 4	Homo sapiens	69-74
7699563-0	1994	Gastrointestinal effects of diazepam-withdrawal are linked to activation of central cholecystokinin-ergic pathways in rats.	Diazepam	28-36	cholecystokinin	Rattus norvegicus	84-99
7699563-5	1994	It is concluded that in rats precipitated diazepam-withdrawal altered intestinal motility and colonic transit and that these effects are mediated by central release of cholecystokinin (CCK) or activation of CCK-ergic neurons.	Diazepam	42-50	cholecystokinin	Rattus norvegicus	168-183
7699563-5	1994	It is concluded that in rats precipitated diazepam-withdrawal altered intestinal motility and colonic transit and that these effects are mediated by central release of cholecystokinin (CCK) or activation of CCK-ergic neurons.	Diazepam	42-50	cholecystokinin	Rattus norvegicus	185-188
7699563-5	1994	It is concluded that in rats precipitated diazepam-withdrawal altered intestinal motility and colonic transit and that these effects are mediated by central release of cholecystokinin (CCK) or activation of CCK-ergic neurons.	Diazepam	42-50	cholecystokinin	Rattus norvegicus	207-210
20693072-2	1994	Considerable alterations in mitogen-stimulated cytokine production in rats exposed to diazepam prenatally have now been observed: TNF-alpha liberation by splenocytes of diazepam-exposed rats was reduced at 2 wk of age and increased above control values at 8 wk, and interleukin (IL)-6 was depressed in the offspring at 2 and 8 wk of age.	Diazepam	86-94	tumor necrosis factor	Rattus norvegicus	130-139
20693072-2	1994	Considerable alterations in mitogen-stimulated cytokine production in rats exposed to diazepam prenatally have now been observed: TNF-alpha liberation by splenocytes of diazepam-exposed rats was reduced at 2 wk of age and increased above control values at 8 wk, and interleukin (IL)-6 was depressed in the offspring at 2 and 8 wk of age.	Diazepam	86-94	interleukin 6	Rattus norvegicus	266-284
20693072-2	1994	Considerable alterations in mitogen-stimulated cytokine production in rats exposed to diazepam prenatally have now been observed: TNF-alpha liberation by splenocytes of diazepam-exposed rats was reduced at 2 wk of age and increased above control values at 8 wk, and interleukin (IL)-6 was depressed in the offspring at 2 and 8 wk of age.	Diazepam	169-177	tumor necrosis factor	Rattus norvegicus	130-139
20693072-2	1994	Considerable alterations in mitogen-stimulated cytokine production in rats exposed to diazepam prenatally have now been observed: TNF-alpha liberation by splenocytes of diazepam-exposed rats was reduced at 2 wk of age and increased above control values at 8 wk, and interleukin (IL)-6 was depressed in the offspring at 2 and 8 wk of age.	Diazepam	169-177	interleukin 6	Rattus norvegicus	266-284
7817789-6	1994	DZP decreased plasma glucose concentrations by 6-12% at P5, P14 and P21, whereas undernutrition did not change plasma glucose concentrations, except for a 7% decrease at P14.	Diazepam	0-3	S100 calcium binding protein A9	Rattus norvegicus	60-63
7981013-0	1994	Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.	Diazepam	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-101
7981013-2	1994	The primary metabolism of diazepam was studied in human liver microsomes in order to investigate the kinetics and to identify the cytochrome P450 (CYP) isoforms responsible for the formation of the main diazepam metabolites, temazepam and N-desmethyldiazepam.	Diazepam	26-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	130-145
7981013-2	1994	The primary metabolism of diazepam was studied in human liver microsomes in order to investigate the kinetics and to identify the cytochrome P450 (CYP) isoforms responsible for the formation of the main diazepam metabolites, temazepam and N-desmethyldiazepam.	Diazepam	26-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	147-150
7981013-2	1994	The primary metabolism of diazepam was studied in human liver microsomes in order to investigate the kinetics and to identify the cytochrome P450 (CYP) isoforms responsible for the formation of the main diazepam metabolites, temazepam and N-desmethyldiazepam.	Diazepam	203-211	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	130-145
7981013-2	1994	The primary metabolism of diazepam was studied in human liver microsomes in order to investigate the kinetics and to identify the cytochrome P450 (CYP) isoforms responsible for the formation of the main diazepam metabolites, temazepam and N-desmethyldiazepam.	Diazepam	203-211	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	147-150
7817789-8	1994	The conversion of [14C]glucose into cerebral amino acids was reduced by DZP at P5 and P10.	Diazepam	72-75	protein disulfide isomerase family A, member 6	Rattus norvegicus	79-89
7817789-10	1994	After [U-14C]glucose injection, specific radioactivities of cerebral amino acids were mostly decreased by DZP from P5 to P14 and significantly increased at P21.	Diazepam	106-109	S100 calcium binding protein A9	Rattus norvegicus	121-124
7817789-12	1994	In conclusion, P5 and P10 rats appear to be most sensitive to DZP effects whereas some tolerance to the drug seems to develop by P21.	Diazepam	62-65	protein disulfide isomerase family A, member 6	Rattus norvegicus	15-25
7936097-9	1994	Diazepam (3 mg/kg) reduced the duration of the discharge and also reduced the amplitude of population spikes recorded in CA1.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	121-124
7952860-13	1994	For instance,diazepam only in the alpha 1 beta2 gamma 2 and alpha 3 beta 2 gamma 2 subtypes, and 5 alpha-THDOC in all the subtypes enhanced TBPS binding in the absence of GABA, and intensified the inhibitory effect of GABA.	Diazepam	13-21	crystallin, gamma E	Rattus norvegicus	48-55
7952860-13	1994	For instance,diazepam only in the alpha 1 beta2 gamma 2 and alpha 3 beta 2 gamma 2 subtypes, and 5 alpha-THDOC in all the subtypes enhanced TBPS binding in the absence of GABA, and intensified the inhibitory effect of GABA.	Diazepam	13-21	crystallin, gamma E	Rattus norvegicus	75-82
8168866-0	1994	Diazepam binding inhibitor fragment 33-50 (octadecaneuropeptide) immunoreactivity in the cerebellar cortex is restricted to glial cells.	Diazepam	0-8	diazepam binding inhibitor	Rattus norvegicus	43-63
8179134-0	1994	Delayed ACTH response to human corticotropin releasing hormone during cardiopulmonary bypass under diazepam-high dose fentanyl anaesthesia.	Diazepam	99-107	proopiomelanocortin	Homo sapiens	8-12
8179134-0	1994	Delayed ACTH response to human corticotropin releasing hormone during cardiopulmonary bypass under diazepam-high dose fentanyl anaesthesia.	Diazepam	99-107	corticotropin releasing hormone	Homo sapiens	31-62
8185192-0	1994	The CCK-B antagonist LY288513 blocks diazepam-withdrawal-induced increases in auditory startle response.	Diazepam	37-45	cholecystokinin B receptor	Homo sapiens	4-9
8145733-7	1994	The apparent potency of GABA was increased 2-fold by diazepam with alpha 1 beta 2 gamma 2 receptors, 3-fold with alpha 3 beta 2 gamma 2 receptors, and 5-fold with alpha 1 alpha 3 beta 2 gamma 2 receptors.	Diazepam	53-61	adrenoceptor alpha 1D	Homo sapiens	67-89
8145733-7	1994	The apparent potency of GABA was increased 2-fold by diazepam with alpha 1 beta 2 gamma 2 receptors, 3-fold with alpha 3 beta 2 gamma 2 receptors, and 5-fold with alpha 1 alpha 3 beta 2 gamma 2 receptors.	Diazepam	53-61	adrenoceptor alpha 1D	Homo sapiens	67-74
8110193-1	1994	Acyl-CoA-binding protein (ACBP), also named diazepam-binding inhibitor or endozepine, is a 10 kDa protein for which a surprisingly large number of biological activities has been suggested.	Diazepam	44-52	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-24
8110193-1	1994	Acyl-CoA-binding protein (ACBP), also named diazepam-binding inhibitor or endozepine, is a 10 kDa protein for which a surprisingly large number of biological activities has been suggested.	Diazepam	44-52	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	26-30
8125973-6	1994	The induction of PBR/IBP mRNA was also observed in MEL cells induced with diazepam.	Diazepam	74-82	translocator protein	Mus musculus	21-24
8085710-6	1994	Nevertheless, some neuro-endocrine effects of BZD are mediated through actions on BZD receptors in the pituitary gland: we reported an inhibition of TRH induced PRL release by diazepam (treatment of 7 days) in anxious patients.	Diazepam	176-184	thyrotropin releasing hormone	Homo sapiens	149-152
8159805-1	1994	This report describes the purification and characterization from rat brain of DBI39-75, a novel, biologically active processing product of diazepam binding inhibitor (DBI).	Diazepam	139-147	diazepam binding inhibitor	Rattus norvegicus	78-81
7770620-3	1994	Several neurotransmitter antagonists, including haloperidol, clozapine, SCH-22390, diazepam, and muscimol, inhibited induction of HSP70 produced by PCP.	Diazepam	83-91	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	130-135
7903909-8	1994	Conversely, the formation of metabolite M5 remained unaffected by antibodies against CYP3A and by CYP3A substrates but was sensitive to diazepam inhibition, a preferential substrate of CYP2C.	Diazepam	136-144	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	185-190
7911985-0	1994	Increase of tyrosine hydroxylase and its mRNA in the rat substantia nigra pars reticulata by diazepam and picrotoxin.	Diazepam	93-101	tyrosine hydroxylase	Rattus norvegicus	12-32
7911985-2	1994	The number of TH-positive cells was increased for both ISH and IMHC 8 h after a single administration of benzodiazepine diazepam, which facilitates GABAA-receptor-mediated transmission and reduces dopamine release in the substantia nigra (SN).	Diazepam	120-128	tyrosine hydroxylase	Rattus norvegicus	14-16
7911985-3	1994	Such increase in TH staining was suppressed when a dopamine D2 receptor agonist quinpirole was administered 10 min after diazepam.	Diazepam	121-129	tyrosine hydroxylase	Rattus norvegicus	17-19
7911985-4	1994	Co-administration of diazepam with a dopamine antagonist haloperidol did not further elevate, but rather, reduced haloperidol-induced increases in TH labeling.	Diazepam	21-29	tyrosine hydroxylase	Rattus norvegicus	147-149
7911985-5	1994	These results suggest that haloperidol and diazepam regulate TH gene expression in the SNr commonly by depressing dopaminergic transmission, and that diazepam activates TH expression in a group of SNr neurons which express this gene after haloperidol treatment.	Diazepam	43-51	tyrosine hydroxylase	Rattus norvegicus	61-63
7911985-5	1994	These results suggest that haloperidol and diazepam regulate TH gene expression in the SNr commonly by depressing dopaminergic transmission, and that diazepam activates TH expression in a group of SNr neurons which express this gene after haloperidol treatment.	Diazepam	150-158	tyrosine hydroxylase	Rattus norvegicus	169-171
7888420-0	1994	CSF levels of diazepam-binding inhibitor correlate with REM latency in schizophrenia, a pilot study.	Diazepam	14-22	colony stimulating factor 2	Homo sapiens	0-3
8148870-0	1993	Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.	Diazepam	39-47	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
7761789-8	1994	Following treatment of dichlorvos poisoning with atropine, obidoxime and diazepam, the delayed and lower increase of TAT activity was observed.	Diazepam	73-81	tyrosine aminotransferase	Rattus norvegicus	117-120
8298983-4	1993	CRH induced a significant (P &lt; 0.01) reduction of splenic natural killer cell activity which was completely antagonized by pretreatment with either diazepam or alprazolam.	Diazepam	151-159	corticotropin releasing hormone	Homo sapiens	0-3
7908973-0	1993	Human serum albumin conformational changes as induced by tenoxicam and modified by simultaneous diazepam binding.	Diazepam	96-104	albumin	Homo sapiens	6-19
8148870-0	1993	Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.	Diazepam	39-47	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	87-92
8153057-0	1993	Diazepam treatment of pregnant rats differentially affects interleukin-1 and interleukin-2 secretion in their offspring during different phases of postnatal development.	Diazepam	0-8	interleukin 2	Rattus norvegicus	77-90
8148870-2	1993	Microsomal 3-hydroxylation was the major pathway of DZP metabolism in rats and was inhibited by anti-CYP3A antibodies.	Diazepam	52-55	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	101-106
8153057-4	1993	Lipopolysaccharide-stimulated release of macrophage-derived IL-1 by spleen cells, determined on D10.G4.1 cells, remained in the control range during the preweaning period (postnatal day 6-28), then decreased in prenatally diazepam-exposed offspring, significantly in males during the postweaning period (postnatal day 34-61) and in both sexes in adults (postnatal day 62-83).	Diazepam	222-230	interleukin 1 complex	Mus musculus	60-64
8148870-8	1993	On the other hand, DZP 3-hydroxylation was rather selectively catalysed by a CYP3A P450 at the low and high substrate concentrations.	Diazepam	19-22	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	77-82
8148870-10	1993	These results also suggest that the apparent discrepancy on the role of CYP forms in DZP metabolism in vitro and in vivo may reside in the difference in substrate concentration.	Diazepam	85-88	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	72-75
8111002-0	1993	The CCK-B antagonist LY288513 blocks effects of diazepam withdrawal on auditory startle.	Diazepam	48-56	cholecystokinin B receptor	Homo sapiens	4-9
8258357-3	1993	The mutant alpha 6(Q100)beta 2 gamma 2 recombinant receptors are sensitive to diazepam.	Diazepam	78-86	crystallin, gamma E	Rattus norvegicus	31-38
8301019-13	1993	Spleen cells stimulated with Con A and cultivated with the highest concentration of diazepam and clonazepam formed markedly greater amounts of IL-2 than those cultivated in medium, while at this concentration PK 11195 allowed no formation of the lymphokine.	Diazepam	84-92	interleukin 2	Mus musculus	143-147
7904070-3	1993	The results show that the three 5-HT1A agonists had a smaller anticonflict effect than diazepam.	Diazepam	87-95	5-hydroxytryptamine receptor 1A	Rattus norvegicus	32-38
8258357-7	1993	GABA effects on [35S]TBPS binding were only slightly affected by diazepam in the alpha 6(Q100) beta 2 gamma 2 receptors, while profound effects were seen in the alpha 1 beta 2 gamma 2 receptors in the presence of diazepam.	Diazepam	65-73	crystallin, gamma E	Rattus norvegicus	102-109
8396629-0	1993	Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.	Diazepam	104-112	carbonic anhydrase 1	Homo sapiens	137-140
8510706-6	1993	A survival analysis of the length of time to the first recurrent febrile seizure did not show a significant difference between the treatment groups (P = 0.064 by the log-rank test), but after adjustment for covariates, diazepam was found to have a benefit (P = 0.027 by Cox regression analysis).	Diazepam	219-227	cytochrome c oxidase subunit 8A	Homo sapiens	270-273
8332636-1	1993	The effect of 5-HT3 receptor antagonists such as ondansetron, ICS 205-930, MDL 72222, metoclopramide, and zacopride was investigated on the ethanol as well as diazepam withdrawal phenomena in the present study.	Diazepam	159-167	5-hydroxytryptamine receptor 3A	Rattus norvegicus	14-28
8233052-4	1993	Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA.	Diazepam	0-8	epistatic circling SWR/J	Mus musculus	32-35
8233052-4	1993	Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA.	Diazepam	0-8	heat shock protein 8	Mus musculus	78-83
8304244-0	1993	Alterations in interleukin-6 production by LPS- and Con A-stimulated mixed splenocytes, spleen macrophages and lymphocytes in prenatally diazepam-exposed rats.	Diazepam	137-145	interleukin 6	Rattus norvegicus	15-28
8304244-1	1993	Prenatal exposure to diazepam leads to a suppression of mitogen or allogen-induced lymphocyte proliferation as well as to a reduced production of tumour necrosis factor (TNF)-alpha from rat splenocytes during postnatal development of rats.	Diazepam	21-29	tumor necrosis factor	Rattus norvegicus	146-180
8304244-4	1993	In response to LPS, IL-6 liberation was significantly lower in mixed splenocytes and spleen macrophages of 2 and 8 week old prenatally diazepam-treated rats than in controls.	Diazepam	135-143	interleukin 6	Rattus norvegicus	20-24
8390198-0	1993	Effect of diazepam and baclofen upon alpha-MSH-induced behavior related with cyclic AMP levels in accumbens and caudate putamen.	Diazepam	10-18	proopiomelanocortin	Homo sapiens	37-46
8210691-6	1993	To assess diazepam-effects on collecting tubule response to vasopressin, the effects of desmopressin on concentrating ability in control and diazepam-treated rats were tested.	Diazepam	10-18	arginine vasopressin	Rattus norvegicus	60-71
8232254-1	1993	Acyl-CoA-binding protein has been isolated independently by five different groups based on its ability to (1) displace diazepam from the GABAA receptor, (2) affect cell growth, (3) induce medium-chain acyl-CoA-ester synthesis, (4) stimulate steroid hormone synthesis, and (5) affect glucose-induced insulin secretion.	Diazepam	119-127	diazepam binding inhibitor	Rattus norvegicus	0-24
8100621-3	1993	Diazepam (2 mg/kg) also counteracted the reduction of time spent immobile induced by the MAO inhibitors, toloxatone (256 mg/kg) and selegiline (4 mg/kg) and the 5-HT1A receptor agonist, 8-OH-DPAT (1 mg/kg), but not by the psychostimulant, caffeine (32 mg/kg).	Diazepam	0-8	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	161-176
8332543-0	1993	Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors.	Diazepam	12-20	angiotensinogen	Homo sapiens	66-80
8507349-5	1993	Both responses were completely prevented by a pretreatment with diazepam (5 mg/kg, IP), which suggested that adrenal steroids might be a stimulus underlying the rapid increase in NGF biosynthesis following bicuculline convulsions.	Diazepam	64-72	nerve growth factor	Rattus norvegicus	179-182
8332543-0	1993	Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors.	Diazepam	12-20	angiotensin II receptor type 1	Homo sapiens	85-88
8332543-2	1993	These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII.	Diazepam	94-102	angiotensinogen	Homo sapiens	117-120
8332543-2	1993	These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII.	Diazepam	104-106	angiotensinogen	Homo sapiens	117-120
8491257-2	1993	In cerebral cortex and a subpopulation of hippocampal neurones, CCK mRNA levels were increased after a single injection of diazepam and 24 h after withdrawal from chronic diazepam treatment, but not after chronic diazepam treatment.	Diazepam	123-131	cholecystokinin	Rattus norvegicus	64-67
8101567-3	1993	In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam.	Diazepam	179-187	protein tyrosine phosphatase receptor type U	Homo sapiens	86-89
8491257-2	1993	In cerebral cortex and a subpopulation of hippocampal neurones, CCK mRNA levels were increased after a single injection of diazepam and 24 h after withdrawal from chronic diazepam treatment, but not after chronic diazepam treatment.	Diazepam	171-179	cholecystokinin	Rattus norvegicus	64-67
8491257-2	1993	In cerebral cortex and a subpopulation of hippocampal neurones, CCK mRNA levels were increased after a single injection of diazepam and 24 h after withdrawal from chronic diazepam treatment, but not after chronic diazepam treatment.	Diazepam	171-179	cholecystokinin	Rattus norvegicus	64-67
7681869-7	1993	Whole-cell currents recorded from cells coexpressing alpha 1 beta 1 gamma 2S subunits were three to four times larger than those recorded from cells coexpressing alpha 1 beta 1 subunits, and they were always enhanced by coapplied diazepam.	Diazepam	230-238	adrenoceptor alpha 1D	Homo sapiens	53-60
7681869-7	1993	Whole-cell currents recorded from cells coexpressing alpha 1 beta 1 gamma 2S subunits were three to four times larger than those recorded from cells coexpressing alpha 1 beta 1 subunits, and they were always enhanced by coapplied diazepam.	Diazepam	230-238	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	61-67
7681869-7	1993	Whole-cell currents recorded from cells coexpressing alpha 1 beta 1 gamma 2S subunits were three to four times larger than those recorded from cells coexpressing alpha 1 beta 1 subunits, and they were always enhanced by coapplied diazepam.	Diazepam	230-238	adrenoceptor alpha 1D	Homo sapiens	162-169
7681869-7	1993	Whole-cell currents recorded from cells coexpressing alpha 1 beta 1 gamma 2S subunits were three to four times larger than those recorded from cells coexpressing alpha 1 beta 1 subunits, and they were always enhanced by coapplied diazepam.	Diazepam	230-238	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	170-176
8095340-5	1993	In females, but not males, these calls were reduced in number by gepirone, 5-hydroxytryptamine1A (5-HT1A) agonist, at both 1.0- and 10.0-mg/kg doses and by diazepam, a benzodiazepine, at 3.0 but not 1.0 mg/kg.	Diazepam	156-164	5-hydroxytryptamine receptor 1A	Rattus norvegicus	98-104
8213353-0	1993	The effect of prenatal diazepam exposure on TNF-alpha production by rat splenocytes.	Diazepam	23-31	tumor necrosis factor	Rattus norvegicus	44-53
8213353-4	1993	However, at eight weeks of age, prenatally diazepam-treated animals showed a significantly higher LPS-induced TNF-alpha release than control rats.	Diazepam	43-51	tumor necrosis factor	Rattus norvegicus	110-119
8213353-7	1993	Thus, our data indicate that a disturbance in TNF-alpha release from macrophages is involved in the deficient immune response of prenatally diazepam-exposed rats.	Diazepam	140-148	tumor necrosis factor	Rattus norvegicus	46-55
8471377-5	1993	FMLP-induced PMN chemiluminescence was depressed 10-100 fold more by diazepam and midazolam than zymosan-induced chemiluminescence.	Diazepam	69-77	formyl peptide receptor 1	Homo sapiens	0-4
8388870-4	1993	Moreover, we used a specific radioimmunoassay to identify in these cells the presence of the polypeptide diazepam binding inhibitor (DBI), a putative endogenous ligand for various benzodiazepine receptors including the peripheral type.	Diazepam	105-113	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	133-136
8385255-1	1993	Since their first description as anomalous high affinity diazepam binding sites in rat peripheral tissues, the peripheral-type benzodiazepine receptor (PBR) has been increasingly studied to better understand nonneural effects of the benzodiazepines.	Diazepam	57-65	translocator protein	Rattus norvegicus	111-150
7907456-17	1993	It is demonstrated that administration of diazepam and GABA uptake inhibitors during this period offers postischemic neuron protection in CA1.	Diazepam	42-50	carbonic anhydrase 1	Rattus norvegicus	138-141
8385252-1	1993	High-affinity binding sites for the isoquinoline carboxamide PK 11195 and 4"-chlorodiazepam (4"CD) in human lymphocytes are recognized by two putative endogenous ligands: diazepam binding inhibitor (DBI) and protoporphyrin IX.	Diazepam	83-91	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	199-202
1286434-4	1992	Animals pretreated with diazepam (5 mg/kg, ip) tolerated intraventricular dose of domoic acid 0.4 microgram, but showed a loss of pyramidal neurons mainly in the CA3, CA4, and a part of CA1 areas of the dorsal hippocampus.	Diazepam	24-32	carbonic anhydrase 3	Rattus norvegicus	162-165
1286434-4	1992	Animals pretreated with diazepam (5 mg/kg, ip) tolerated intraventricular dose of domoic acid 0.4 microgram, but showed a loss of pyramidal neurons mainly in the CA3, CA4, and a part of CA1 areas of the dorsal hippocampus.	Diazepam	24-32	carbonic anhydrase 4	Rattus norvegicus	167-170
1286434-4	1992	Animals pretreated with diazepam (5 mg/kg, ip) tolerated intraventricular dose of domoic acid 0.4 microgram, but showed a loss of pyramidal neurons mainly in the CA3, CA4, and a part of CA1 areas of the dorsal hippocampus.	Diazepam	24-32	carbonic anhydrase 1	Rattus norvegicus	186-189
1302786-7	1992	Diazepam reduced this stimulation-induced increase of plasma NPY-IR in a dose-dependent manner.	Diazepam	0-8	neuropeptide Y	Rattus norvegicus	61-64
1344831-4	1992	Omeprazole interacts with the cytochrome P-450 system in the liver: inhibition of several liver mono-oxygenases activities (inhibitory effect on diazepam, phenytoin and R-warfarin metabolism with prolonged elimination); induction of P-450 (IA1 and IA2) enzymes that may potentiate the hepatotoxic effect of phenacetin and acetaminophen or increase the tumorigenic effect of chemical carcinogens (polycyclic aromatic hydrocarbons, arylamines, aflatoxin).	Diazepam	145-153	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-46
1320683-0	1992	Reduction in potency of selective gamma-aminobutyric acidA agonists and diazepam in CA1 region of in vitro hippocampal slices from chronic flurazepam-treated rats.	Diazepam	72-80	carbonic anhydrase 1	Rattus norvegicus	84-87
1323506-2	1992	Five days treatment with the PBR ligands RO 5-4864 or diazepam (DZ) up-regulates kidney PBR.	Diazepam	54-62	translocator protein	Rattus norvegicus	29-32
1323506-2	1992	Five days treatment with the PBR ligands RO 5-4864 or diazepam (DZ) up-regulates kidney PBR.	Diazepam	54-62	translocator protein	Rattus norvegicus	88-91
8098864-6	1993	Administration of diazepam for 3 or 7 days decreased the number of somatostatin receptors in synaptosomes from the hippocampus, without influencing their apparent affinity.	Diazepam	18-26	somatostatin	Rattus norvegicus	67-79
8098864-8	1993	After 2 weeks of daily injections of diazepam the levels of binding of somatostatin in the hippocampus returned to control values, coinciding with the tolerance that develops to chronically-administered benzodiazepine agonists.	Diazepam	37-45	somatostatin	Rattus norvegicus	71-83
1597138-1	1992	Diazepam binding inhibitor-like immunoreactivity (DBI-LI) in normal and hypophysectomized (HPX) rat testis was studied by light and electron microscopic immunohistochemistry.	Diazepam	0-8	diazepam binding inhibitor	Rattus norvegicus	50-53
1317582-2	1992	The steroidogenic capability of this cell line and the regulation of pregnenolone production by 4"-chlorodiazepam (4"CD), a specific ligand for the mitochondrial diazepam binding inhibitor (DBI) receptor (MDR), were investigated.	Diazepam	105-113	malic enzyme complex, mitochondrial	Mus musculus	205-208
1327839-2	1992	The effect of chronic exposure to the benzodiazepine agonist diazepam was also examined on levels of gamma 2 subunit mRNA.	Diazepam	61-69	crystallin, gamma E	Rattus norvegicus	101-108
1327839-9	1992	In rats chronically exposed to diazepam (21 days via silastic implants), levels of gamma 2 subunit mRNA were significantly decreased in cortex, but not changed in either hippocampus or cerebellum.	Diazepam	31-39	crystallin, gamma E	Rattus norvegicus	83-90
1315795-3	1992	All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only.	Diazepam	152-160	interleukin 2	Homo sapiens	101-114
1315795-3	1992	All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only.	Diazepam	152-160	interleukin 2	Homo sapiens	116-120
1302786-12	1992	The obtained results suggest that premedication of diazepam and/or pethidine has the ability to decrease plasma NPY-IR in animals.	Diazepam	51-59	neuropeptide Y	Rattus norvegicus	112-115
1523283-0	1992	Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment?	Diazepam	77-85	5-hydroxytryptamine receptor 3A	Rattus norvegicus	36-50
1329159-0	1992	[Changes in plasma cortisol and ACTH caused by diazepam, bromazepam, triazolam, and alprazolam in oral premedication].	Diazepam	47-55	proopiomelanocortin	Homo sapiens	32-36
1515916-0	1992	Localization and characterization of diazepam-binding inhibitor (DBI)-like peptides in the brain and pituitary of the trout (Salmo gairdneri).	Diazepam	37-45	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	65-68
1515916-1	1992	The distribution of diazepam-binding inhibitor (DBI)-like peptide(s) in the brain and pituitary of the trout was determined by the indirect immunofluorescence technique using an antiserum raised against synthetic rat octadecaneuropeptide (ODN).	Diazepam	20-28	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	48-51
1318081-0	1992	Adrenocorticotropin hormone response to diazepam in healthy young men.	Diazepam	40-48	proopiomelanocortin	Homo sapiens	0-19
1318081-1	1992	The effects of diazepam (DZ) infusions on changes in adrenocorticotropin hormone (ACTH) are a source of debate.	Diazepam	15-23	proopiomelanocortin	Homo sapiens	53-72
1318081-1	1992	The effects of diazepam (DZ) infusions on changes in adrenocorticotropin hormone (ACTH) are a source of debate.	Diazepam	25-27	proopiomelanocortin	Homo sapiens	53-72
1321364-4	1992	Clonazepam (1 and 5 mg/kg) and diazepam (15 mg/kg but not 25 mg/kg) decreased even the TRH-induced PRL levels.	Diazepam	31-39	prolactin	Rattus norvegicus	99-102
1541364-4	1992	The increase in BDNF and NGF mRNA levels were completely prevented by pretreatment with systemic injections of either scopolamine or diazepam.	Diazepam	133-141	brain-derived neurotrophic factor	Rattus norvegicus	16-20
1541364-4	1992	The increase in BDNF and NGF mRNA levels were completely prevented by pretreatment with systemic injections of either scopolamine or diazepam.	Diazepam	133-141	nerve growth factor	Rattus norvegicus	25-28
1541364-8	1992	The increase in BDNF mRNA after cortex injections was attenuated by diazepam but not by scopolamine.	Diazepam	68-76	brain-derived neurotrophic factor	Rattus norvegicus	16-20
1353287-4	1992	Decreasing neuronal activity by administering the anxiolytic, diazepam, appears to decrease the activity of phospholipase A2.	Diazepam	62-70	phospholipase A2 group IB	Homo sapiens	108-124
1739387-4	1992	In contrast, addition of diazepam in vitro to cockerel plasma caused a concentration-dependent inhibition of LCAT activity.	Diazepam	25-33	lecithin-cholesterol acyltransferase	Homo sapiens	109-113
1725995-8	1991	The cefotiam binding site seems to be close to the warfarin site (site I) whereas cyclohexanol probably shares the diazepam site (site II) on HSA.	Diazepam	115-123	albumin	Homo sapiens	142-145
1312958-1	1992	One of the many effects which have been attributed to the peptide endozepine/diazepam binding inhibitor (Ep/DBI) is the stimulation of adrenocortical and testicular Leydig cell mitochondrial steroidogenesis.	Diazepam	77-85	diazepam binding inhibitor	Mus musculus	108-111
1780035-1	1991	Diazepam binding inhibitor (DBI) is a peptide, initially identified for its ability of displacing the binding of diazepam.	Diazepam	113-121	diazepam binding inhibitor	Rattus norvegicus	0-26
1780035-1	1991	Diazepam binding inhibitor (DBI) is a peptide, initially identified for its ability of displacing the binding of diazepam.	Diazepam	113-121	diazepam binding inhibitor	Rattus norvegicus	28-31
1780035-6	1991	Moreover, the biosynthesis of DBI is up-regulated in the cerebellum and cerebral cortex of rats made tolerant to diazepam, suggesting that changes in the biosynthesis of DBI might be one of the mechanisms eliciting tolerance to benzodiazepine.	Diazepam	113-121	diazepam binding inhibitor	Rattus norvegicus	30-33
1664066-0	1991	Immunohistochemistry of diazepam binding inhibitor (DBI) in the central nervous system and peripheral organs: its possible role as an endogenous regulator of different types of benzodiazepine receptors.	Diazepam	24-32	diazepam binding inhibitor	Rattus norvegicus	52-55
1780035-6	1991	Moreover, the biosynthesis of DBI is up-regulated in the cerebellum and cerebral cortex of rats made tolerant to diazepam, suggesting that changes in the biosynthesis of DBI might be one of the mechanisms eliciting tolerance to benzodiazepine.	Diazepam	113-121	diazepam binding inhibitor	Rattus norvegicus	170-173
1664066-1	1991	The distribution of diazepam binding inhibitor (DBI), a multi-function peptide which has recently been discovered, was studied in the rat and human central nervous system and in peripheral organs of the rat by light and electron microscopical immunohistochemistry.	Diazepam	20-28	diazepam binding inhibitor	Rattus norvegicus	48-51
1683477-7	1991	We have examined the possibility that diazepam may exert some of its anticonvulsant effects through cholinergic mechanisms and found that a reduced release of ACh into synapses after diazepam and atropine treatment may account for diazepam"s anticonvulsant activity against soman.	Diazepam	38-46	acyl-CoA thioesterase 12	Rattus norvegicus	159-162
1663497-2	1991	Diazepam also inhibited the superoxide production induced by FMLP, NaF, and A23187, but not that induced by PMA whose stimulant action was insensitive even to 10(-4) M diazepam.	Diazepam	0-8	formyl peptide receptor 1	Homo sapiens	61-65
1663497-2	1991	Diazepam also inhibited the superoxide production induced by FMLP, NaF, and A23187, but not that induced by PMA whose stimulant action was insensitive even to 10(-4) M diazepam.	Diazepam	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
1663497-3	1991	The FMLP-induced superoxide production was most sensitive to diazepam inhibition (ID50 = 2.25 x 10(-6) M diazepam); the effect of NaF was slightly less sensitive (ID50 = 1.34 x 10(-5) M diazepam); and the effect of A23187 was least sensitive as it was suppressed only at 10(-4) M diazepam concentrations.	Diazepam	61-69	formyl peptide receptor 1	Homo sapiens	4-8
1663497-3	1991	The FMLP-induced superoxide production was most sensitive to diazepam inhibition (ID50 = 2.25 x 10(-6) M diazepam); the effect of NaF was slightly less sensitive (ID50 = 1.34 x 10(-5) M diazepam); and the effect of A23187 was least sensitive as it was suppressed only at 10(-4) M diazepam concentrations.	Diazepam	105-113	formyl peptide receptor 1	Homo sapiens	4-8
1663497-3	1991	The FMLP-induced superoxide production was most sensitive to diazepam inhibition (ID50 = 2.25 x 10(-6) M diazepam); the effect of NaF was slightly less sensitive (ID50 = 1.34 x 10(-5) M diazepam); and the effect of A23187 was least sensitive as it was suppressed only at 10(-4) M diazepam concentrations.	Diazepam	105-113	formyl peptide receptor 1	Homo sapiens	4-8
1663497-3	1991	The FMLP-induced superoxide production was most sensitive to diazepam inhibition (ID50 = 2.25 x 10(-6) M diazepam); the effect of NaF was slightly less sensitive (ID50 = 1.34 x 10(-5) M diazepam); and the effect of A23187 was least sensitive as it was suppressed only at 10(-4) M diazepam concentrations.	Diazepam	105-113	formyl peptide receptor 1	Homo sapiens	4-8
1663497-4	1991	Like diazepam, Ro5-4864 inhibited the FMLP-induced superoxide production, and PK-11195 (10(-5) M) significantly antagonized both diazepam and Ro5-4864 inhibition.	Diazepam	5-13	formyl peptide receptor 1	Homo sapiens	38-42
1806290-5	1991	Unexpectedly, however, the combination treatment of DZP and BCL causes an increase in the NAT activity and melatonin content compared with the BCL-alone group.	Diazepam	52-55	N-acetyltransferase 1	Rattus norvegicus	90-93
1806290-6	1991	Incubation with DZP at higher concentrations resulted in an increase of pineal NAT activity in vitro, but this increase was inhibited by preincubation with PPL, PBZ or BCL.	Diazepam	16-19	N-acetyltransferase 1	Rattus norvegicus	79-82
1806290-7	1991	DZP treatment thus appeared to have different effects on pineal NAT activity in vivo and in vitro.	Diazepam	0-3	N-acetyltransferase 1	Rattus norvegicus	64-67
1683477-7	1991	We have examined the possibility that diazepam may exert some of its anticonvulsant effects through cholinergic mechanisms and found that a reduced release of ACh into synapses after diazepam and atropine treatment may account for diazepam"s anticonvulsant activity against soman.	Diazepam	183-191	acyl-CoA thioesterase 12	Rattus norvegicus	159-162
1683477-7	1991	We have examined the possibility that diazepam may exert some of its anticonvulsant effects through cholinergic mechanisms and found that a reduced release of ACh into synapses after diazepam and atropine treatment may account for diazepam"s anticonvulsant activity against soman.	Diazepam	183-191	acyl-CoA thioesterase 12	Rattus norvegicus	159-162
1709566-4	1991	The diazepam-treated patients had also smaller CSF concentrations of noradrenaline (NA) and of the dopamine metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC).	Diazepam	4-12	colony stimulating factor 2	Homo sapiens	47-50
1654136-2	1991	Diazepam caused dose-dependent decreases in cortisol and increases in GH and dose-independent decreases in ACTH.	Diazepam	0-8	proopiomelanocortin	Homo sapiens	107-111
1668366-4	1991	Administration of the anxiogenic beta-carboline FG 7142 also increased the total number of VTA DA neurons expressing Fos protein, whereas pretreatment with an anxiolytic benzodiazepine (diazepam) partially prevented the stress-induced increase in Fos expression.	Diazepam	186-194	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	247-250
1650838-4	1991	The rank order of potency of a series of PBR ligands displacing the binding was PK11195 approximately equal to Ro5-4864 greater than protoporphyrin IX greater than flunitrazepam greater than diazepam much greater than clonazepam.	Diazepam	191-199	translocator protein	Rattus norvegicus	41-44
1656687-5	1991	Furthermore, we demonstrated that postischemic treatment with diazepam (4 x 15 mg/kg) significantly reduced the CA1 neuron loss.	Diazepam	62-70	carbonic anhydrase 1	Rattus norvegicus	112-115
1654530-3	1991	Clonazepam (5 x 10(-6) M), diazepam (10(-5) M), Ro 5-4864 (10(-5) M) or FG 7142 (10(-5) M) attenuated the response of TRH in the rat duodenum.	Diazepam	27-35	thyrotropin releasing hormone	Rattus norvegicus	118-121
1838347-0	1991	Possible involvement of dopamine D-1 and D-2 receptors in diazepam-induced hyperphagia in rats.	Diazepam	58-66	solute carrier family 3 member 1	Rattus norvegicus	24-44
1996962-1	1991	Binding of L-tryptophan, diazepam and octanoate to defatted human serum albumin was studied at pH 7.0 by equilibrium dialysis at low ligand/protein molar ratios.	Diazepam	25-33	albumin	Homo sapiens	66-79
1868356-1	1991	The effectiveness of diazepam alone or in the presence of atropine sulfate in reversing soman-induced convulsions, inhibition of blood and brain cholinesterase (ChE) activity, and elevation of brain acetylcholine (ACh) and choline (Ch) concentrations in rats was studied.	Diazepam	21-29	butyrylcholinesterase	Rattus norvegicus	161-164
1678655-0	1991	Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.	Diazepam	35-43	interleukin 1 alpha	Homo sapiens	109-148
1838347-12	1991	Thus, these findings suggest that hyperphagia to diazepam is mediated in part by both dopamine D-1 and D-2 receptors in non-deprived rats.	Diazepam	49-57	solute carrier family 3 member 1	Rattus norvegicus	86-106
1975695-4	1990	Both CCK-B antagonists were able to suppress the withdrawal anxiogenesis and produce an anxiolytic effect in mice previously made tolerant to diazepam.	Diazepam	142-150	cholecystokinin	Rattus norvegicus	5-8
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Diazepam	140-148	diazepam binding inhibitor	Rattus norvegicus	0-26
1649940-1	1991	Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitochondrial BZD receptor (MBR) located on the outer mitochondrial membrane.	Diazepam	140-148	diazepam binding inhibitor	Rattus norvegicus	28-31
1705675-3	1990	The neuronal perikaryal death produced in the subicular, CA1 and CA2 regions was only partially decreased by intraperitoneal injections of the anticonvulsants diazepam and MK-801; these drugs were without effect in the CA3 or hilar interneuronal regions.	Diazepam	159-167	carbonic anhydrase 1	Rattus norvegicus	57-60
1705675-3	1990	The neuronal perikaryal death produced in the subicular, CA1 and CA2 regions was only partially decreased by intraperitoneal injections of the anticonvulsants diazepam and MK-801; these drugs were without effect in the CA3 or hilar interneuronal regions.	Diazepam	159-167	carbonic anhydrase 2	Rattus norvegicus	65-68
2403378-5	1990	DIAZ and PROB displaced one another, confirming their common binding site (Site II, the benzodiazepine site) on serum albumin.	Diazepam	0-4	albumin	Homo sapiens	112-125
1646996-1	1991	Evidence suggests that endogenous benzodiazepine receptor ligands such as diazepam binding inhibitor (DBI) and its metabolite octadecaneuropeptide (ODN) may be implicated in the pathogenesis of hepatic encephalopathy.	Diazepam	74-82	diazepam binding inhibitor	Rattus norvegicus	126-146
1646996-1	1991	Evidence suggests that endogenous benzodiazepine receptor ligands such as diazepam binding inhibitor (DBI) and its metabolite octadecaneuropeptide (ODN) may be implicated in the pathogenesis of hepatic encephalopathy.	Diazepam	74-82	diazepam binding inhibitor	Rattus norvegicus	148-151
1654706-4	1991	The amplitude of SW2 that correlated with emotional tension and anxiety fell only as a result of the administration of diazepam.	Diazepam	119-127	WD repeat domain 82 pseudogene 1	Homo sapiens	17-20
1982083-2	1990	Diazepam pretreatment increases bupropion effectiveness, prolongs duration of enhanced passive avoidance response retrieval during D-1 and D-2 receptors activation by (+)3-PPP and decreases both characteristics under selective D-2 receptor activation by quinpirole.	Diazepam	0-8	dopamine receptor D2	Mus musculus	139-151
2266962-6	1990	Recently it was discovered that ACBP is identical to a putative neurotransmitter diazepam binding inhibitor.	Diazepam	81-89	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	32-36
1698365-5	1990	Diazepam suppressed both the convulsion and the induction of Interleukin-1 beta mRNA produced by kainic acid.	Diazepam	0-8	interleukin 1 beta	Rattus norvegicus	61-79
2223898-0	1990	[Diazepam metabolism by multiple forms of cytochrome P-450 in rat liver microsomes].	Diazepam	1-9	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	42-58
2175764-4	1990	When diazepam was premedicated intravenously, elevations of ACTH and cortisol were abolished.	Diazepam	5-13	proopiomelanocortin	Homo sapiens	60-64
2175764-5	1990	Plasma beta-endorphin was still increased but significantly blocked by diazepam pretreatment.	Diazepam	71-79	proopiomelanocortin	Homo sapiens	7-21
1963332-0	1990	[Effects of diazepam and N(6)-cyclohexyladenosine on the level of diazepam-binding inhibitor in structures of the hippocampus during immobilization stress].	Diazepam	12-20	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	66-92
1963332-1	1990	The Diazepam-binding inhibitor (DBI) levels were studied under stress-reaction condition and after diazepam and N6-cyclohexyladenosine injections.	Diazepam	99-107	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	32-35
1963332-4	1990	Diazepam and N6-cyclohexyladenosine injection decreased DBI level in these conditions.	Diazepam	0-8	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	56-59
2169426-15	1990	In conclusion, the pharmacological features of muscimol I type GABA receptors are partly comparable to those of mammalian GABAA receptors, except for the influences of bicuculline and diazepam: the features of the baclofen type GABA receptor, which did not occur with muscimol I type receptors in the same neurone, were similar to those of GABAB.	Diazepam	184-192	GABA type A receptor-associated protein	Homo sapiens	63-76
2364909-6	1990	Diazepam (50 mg/kg, ip) slightly modified AchE and abolished hyperglycemia, hyperlactacidemia, and glycogenolytic effects.	Diazepam	0-8	acetylcholinesterase	Rattus norvegicus	42-46
15235982-5	1990	The PEP/LVET ratio was increased by diazepam while the DPTI (diastolic pressure time index)/TTI (tension time index) was reduced by flunitrazepam and midazolam.	Diazepam	36-44	progestagen associated endometrial protein	Homo sapiens	4-7
2183879-0	1990	Growth hormone response to intravenous diazepam and placebo in 82 healthy men.	Diazepam	39-47	growth hormone 1	Homo sapiens	0-14
2251879-6	1990	On the contrary, higher doses of diazepam, 0.94-2.50 mg/kg for F344 and 2.50 mg/kg for LEW, decreased head-dips, head-dipping duration, and rearings.	Diazepam	33-41	coagulation factor II	Rattus norvegicus	63-73
2159487-7	1990	Diazepam also inhibited 5HT-induced CRH release, but was 40 times less potent than alprazolam.	Diazepam	0-8	corticotropin releasing hormone	Rattus norvegicus	36-39
2183879-2	1990	Both diazepam doses had a significant effect on the growth hormone secretion, with peak values occurring between 30 and 60 min postinfusion, after which levels returned to baseline.	Diazepam	5-13	growth hormone 1	Homo sapiens	52-66
2183879-4	1990	Individual GH responses to diazepam were variable and, when a cut-off point of 7.5 ng/ml GH increase before 90 min postdrug administration was used, 1% of the men demonstrated a response after placebo, 17% after low-dose diazepam, and 37% following high-dose diazepam.	Diazepam	27-35	growth hormone 1	Homo sapiens	11-13
2107017-3	1990	Administration of diazepam (10 mg single oral dose) to those cases not responding to bromocriptine induced a decrease in GH in 58% of the cases and an increase in GH in 42%.	Diazepam	18-26	growth hormone 1	Homo sapiens	121-123
2107017-3	1990	Administration of diazepam (10 mg single oral dose) to those cases not responding to bromocriptine induced a decrease in GH in 58% of the cases and an increase in GH in 42%.	Diazepam	18-26	growth hormone 1	Homo sapiens	163-165
2304452-0	1990	Binding of warfarin, salicylate, and diazepam to genetic variants of human serum albumin with known mutations.	Diazepam	37-45	albumin	Homo sapiens	81-88
2304452-1	1990	Possible effects of single point mutations on the ligand-binding capabilities of human serum albumin (Alb) were investigated by studying the interactions between the strongly bound drugs warfarin, salicylate, and diazepam and five structurally characterized genetic variants of the protein.	Diazepam	213-221	albumin	Homo sapiens	93-100
2304452-1	1990	Possible effects of single point mutations on the ligand-binding capabilities of human serum albumin (Alb) were investigated by studying the interactions between the strongly bound drugs warfarin, salicylate, and diazepam and five structurally characterized genetic variants of the protein.	Diazepam	213-221	albumin	Homo sapiens	102-105
12959254-3	1990	Administration of diazepam or oxazepam caused a different response of the rat hepatic microsomal cytochrome P-450 dependent monooxygenase system.	Diazepam	18-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	97-113
2097287-2	1990	On the other hand, microsomal cytochrome b5 is induced by diazepam only.	Diazepam	58-66	cytochrome b5 type A	Rattus norvegicus	30-43
2252845-1	1990	The stereochemistry of an achiral (Diazepam) and two chiral (3-methyl and 3-succinyloxy substituted) 1,4-benzodiazepin-2-ones interacting with human serum albumin (HSA) has been investigated by making use of difference absorption (UV) and circular dichroism (CD) spectroscopies.	Diazepam	35-43	albumin	Homo sapiens	149-162
2097287-1	1990	Among the benzodiazepines tested (diazepam, oxazepam, clonazepam, nitrazepam and chlordiazepoxide ) chlordiazepoxide is the most potent inducer of cytochrome P-450, diazepam is a poor inducer, whereas clonazepam and nitrazepam do not possess a capacity to induce of cytochrome P-450.	Diazepam	34-42	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	147-163
26159874-5	2015	The incidence of PM status by phenotype following administration of omeprazole/esomeprazole (known inhibitors of CYP2C19) was 10-fold higher than those who are genetically PMs in the general population, which could have critical clinical implications for personalizing medications primarily metabolized by CYP2C19, such as clopidogrel, PPI, cyclophosphamide, thalidomide, citalopram, clonazepam, diazepam, phenytoin, etc.	Diazepam	396-404	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	113-120
2203069-8	1990	Importantly, the 5-HT3 receptor antagonists are highly effective to prevent the behavioral syndrome following withdrawal from treatment with diazepam, nicotine, cocaine and alcohol.	Diazepam	141-149	5-hydroxytryptamine receptor 3A	Rattus norvegicus	17-31
1691454-5	1990	However, the diazepam augmentation of beta adrenergic induction of serotonin N-acetyltransferase activity was blocked by isatin.	Diazepam	13-21	aralkylamine N-acetyltransferase	Rattus norvegicus	67-96
34503953-3	2021	Three CYP3A4 substrates, midazolam, ticlopidine, and diazepam, display non-Michaelis-Menten kinetics, form multiple primary metabolites, and are sequentially metabolized to secondary metabolites.	Diazepam	53-61	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	6-12
34791657-0	2022	Global transgenic upregulation of KCC2 confers enhanced diazepam efficacy in treating sustained seizures.	Diazepam	56-64	solute carrier family 12, member 5	Mus musculus	34-38
34791657-7	2022	Overexpression of KCC2 prior to the chemoconvulsant challenge did not affect seizure latency or other measures of seizure severity, but it did increase diazepam"s efficacy in stopping EEG seizures.	Diazepam	152-160	solute carrier family 12, member 5	Mus musculus	18-22
34791657-8	2022	Spike rate, time in seizure, and EEG spectral power following diazepam (5 mg/kg, i.p) were all significantly lower in KCC2 overexpression mice as compared to control mice.	Diazepam	62-70	solute carrier family 12, member 5	Mus musculus	118-122
34719607-0	2021	Diazepam ameliorated myocardial ischemia-reperfusion injury via inhibition of C-C chemokine receptor type 2/Tumor necrosis factor-alpha/Interleukins and Bcl-2-associated X protein/Caspase-3 pathways in experimental rats.	Diazepam	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	153-179
34719607-0	2021	Diazepam ameliorated myocardial ischemia-reperfusion injury via inhibition of C-C chemokine receptor type 2/Tumor necrosis factor-alpha/Interleukins and Bcl-2-associated X protein/Caspase-3 pathways in experimental rats.	Diazepam	0-8	caspase 3	Rattus norvegicus	180-189
34719607-7	2021	In addition, diazepam prominently (P<0.05) improved cardiac Na+K+ATPase, Ca2+ATPase levels and HIF-1alpha (Hypoxia-Inducible Factor-1 alpha) mRNA expression.	Diazepam	13-21	carbonic anhydrase 2	Rattus norvegicus	73-83
34719607-7	2021	In addition, diazepam prominently (P<0.05) improved cardiac Na+K+ATPase, Ca2+ATPase levels and HIF-1alpha (Hypoxia-Inducible Factor-1 alpha) mRNA expression.	Diazepam	13-21	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	95-105
34719607-7	2021	In addition, diazepam prominently (P<0.05) improved cardiac Na+K+ATPase, Ca2+ATPase levels and HIF-1alpha (Hypoxia-Inducible Factor-1 alpha) mRNA expression.	Diazepam	13-21	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	107-139
34719607-9	2021	In western blot analysis, IRI-induced myocardial apoptosis was reduced by diazepam treatment reflected by a marked (P<0.05) decreased in Bax (Bcl-2-associated X protein) and Caspase-3 protein expression.	Diazepam	74-82	BCL2 associated X, apoptosis regulator	Rattus norvegicus	137-140
34719607-9	2021	In western blot analysis, IRI-induced myocardial apoptosis was reduced by diazepam treatment reflected by a marked (P<0.05) decreased in Bax (Bcl-2-associated X protein) and Caspase-3 protein expression.	Diazepam	74-82	BCL2 associated X, apoptosis regulator	Rattus norvegicus	142-168
34719607-11	2021	In conclusion, diazepam exerts cardioprotective effect by inhibiting inflammatory release (CCR2, TNF-alpha, and ILs), oxido-nitrosative stress, and apoptosis (Bax and Caspase-3) pathway during myocardial IRI in experimental rats.	Diazepam	15-23	C-C motif chemokine receptor 2	Rattus norvegicus	91-95
34719607-11	2021	In conclusion, diazepam exerts cardioprotective effect by inhibiting inflammatory release (CCR2, TNF-alpha, and ILs), oxido-nitrosative stress, and apoptosis (Bax and Caspase-3) pathway during myocardial IRI in experimental rats.	Diazepam	15-23	tumor necrosis factor	Rattus norvegicus	97-106
34719607-11	2021	In conclusion, diazepam exerts cardioprotective effect by inhibiting inflammatory release (CCR2, TNF-alpha, and ILs), oxido-nitrosative stress, and apoptosis (Bax and Caspase-3) pathway during myocardial IRI in experimental rats.	Diazepam	15-23	BCL2 associated X, apoptosis regulator	Rattus norvegicus	159-162
34719607-11	2021	In conclusion, diazepam exerts cardioprotective effect by inhibiting inflammatory release (CCR2, TNF-alpha, and ILs), oxido-nitrosative stress, and apoptosis (Bax and Caspase-3) pathway during myocardial IRI in experimental rats.	Diazepam	15-23	caspase 3	Rattus norvegicus	167-176
34503953-10	2021	Significance Statement The metabolism of midazolam, ticlopidine, and diazepam by CYP3A4 results in multiple metabolites and sequential metabolism.	Diazepam	69-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
34229248-6	2021	Diazepam was selected to illustrate different levels of drug plasma-protein binding by changing the added concentration of human serum albumin.	Diazepam	0-8	albumin	Rattus norvegicus	129-142
34899279-14	2021	The spine density of hippocampal neurons was decreased by chronic DZP administration in the CA1 of both young and middle-aged mice as well as in the CA3 of middle-aged mice.	Diazepam	66-69	carbonic anhydrase 1	Mus musculus	92-95
34899279-17	2021	The chronic DZP-induced memory retrieval performance impairment in middle-aged mice can likely be attributed to decreased LTP and dendritic spine density in hippocampal neurons in the CA3.	Diazepam	12-15	carbonic anhydrase 3	Mus musculus	184-187
34565656-1	2021	Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABAA receptor, and was thus termed diazepam binding inhibitor (DBI).	Diazepam	129-137	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	183-209
34565656-1	2021	Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABAA receptor, and was thus termed diazepam binding inhibitor (DBI).	Diazepam	129-137	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	211-214
34528073-18	2022	Finally, in an in vivo kainic acid (KA) model of diazepam-resistant SE, WNK463 slowed the onset and reduced the severity of KA-induced status epilepticus.	Diazepam	49-57	squalene epoxidase	Rattus norvegicus	68-70
34528073-21	2022	Our work suggests that agents which act to increase KCC2 activity may be useful adjunct therapeutics to alleviate diazepam-resistant SE.	Diazepam	114-122	solute carrier family 12, member 5	Mus musculus	52-56
34899279-13	2021	LTP was attenuated by DZP administration in the CA1 of young mice and the CA3 of middle-aged mice.	Diazepam	22-25	carbonic anhydrase 1	Mus musculus	48-51
34500037-9	2021	Treatment with diazepam decreased the expression of FosB/DeltaFosB in all analyzed structures of animals subject to UCS and exodontia + UCS, while promoted a reduction in the FosB/DeltaFosB expression in the CeA, PVN and dPAG in animals subject to exodontia.	Diazepam	15-23	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-56
34500037-9	2021	Treatment with diazepam decreased the expression of FosB/DeltaFosB in all analyzed structures of animals subject to UCS and exodontia + UCS, while promoted a reduction in the FosB/DeltaFosB expression in the CeA, PVN and dPAG in animals subject to exodontia.	Diazepam	15-23	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-66
34500037-9	2021	Treatment with diazepam decreased the expression of FosB/DeltaFosB in all analyzed structures of animals subject to UCS and exodontia + UCS, while promoted a reduction in the FosB/DeltaFosB expression in the CeA, PVN and dPAG in animals subject to exodontia.	Diazepam	15-23	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	175-179
34500037-9	2021	Treatment with diazepam decreased the expression of FosB/DeltaFosB in all analyzed structures of animals subject to UCS and exodontia + UCS, while promoted a reduction in the FosB/DeltaFosB expression in the CeA, PVN and dPAG in animals subject to exodontia.	Diazepam	15-23	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	180-189
34500037-9	2021	Treatment with diazepam decreased the expression of FosB/DeltaFosB in all analyzed structures of animals subject to UCS and exodontia + UCS, while promoted a reduction in the FosB/DeltaFosB expression in the CeA, PVN and dPAG in animals subject to exodontia.	Diazepam	15-23	carcinoembryonic antigen gene family 4	Rattus norvegicus	208-211
34720165-0	2021	Effects of CYP2C19*17 Genetic Polymorphisms on the Steady-State Concentration of Diazepam in Patients With Alcohol Withdrawal Syndrome.	Diazepam	81-89	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	11-18
34720165-3	2021	Aim: The purpose of our study was to investigate the effects of CYP2C19*17 genetic polymorphisms on the steady-state concentration of diazepam in patients with AWS.	Diazepam	134-142	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	64-71
34720165-10	2021	Conclusion: Thus, our study enrolling 50 patients with AWS, showed the effects of CYP2C19*17 genetic polymorphisms on the efficacy and safety rates of diazepam.	Diazepam	151-159	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	82-89
34354703-3	2021	We observed that treatment with DZ and Lipopolysaccharide (LPS) on macrophages or dendritic cells (DCs) induced a defective secretion of IL-12, TNF-alpha, IL-6 and a lesser expression of classical activation markers as NO production and CD40 in comparison with LPS condition.	Diazepam	32-34	tumor necrosis factor	Mus musculus	144-153
34354703-3	2021	We observed that treatment with DZ and Lipopolysaccharide (LPS) on macrophages or dendritic cells (DCs) induced a defective secretion of IL-12, TNF-alpha, IL-6 and a lesser expression of classical activation markers as NO production and CD40 in comparison with LPS condition.	Diazepam	32-34	interleukin 6	Mus musculus	155-159
34354703-3	2021	We observed that treatment with DZ and Lipopolysaccharide (LPS) on macrophages or dendritic cells (DCs) induced a defective secretion of IL-12, TNF-alpha, IL-6 and a lesser expression of classical activation markers as NO production and CD40 in comparison with LPS condition.	Diazepam	32-34	CD40 antigen	Mus musculus	237-241
34354703-5	2021	The DZ treatment shifted the LPS-induced pro-inflammatory cytokine production of peritoneal cells (PCs) to an anti-inflammatory profile commanded by IL-10.	Diazepam	4-6	interleukin 10	Mus musculus	149-154
34354703-9	2021	Additionally, DZ reduced the release of IFN-gamma and IL-17 by splenocytes from untreated sick mice in vitro.	Diazepam	14-16	interferon gamma	Mus musculus	40-49
34354703-9	2021	Additionally, DZ reduced the release of IFN-gamma and IL-17 by splenocytes from untreated sick mice in vitro.	Diazepam	14-16	interleukin 17A	Mus musculus	54-59
32956075-6	2021	Toxicological analyses identified in blood several drugs, including diazepam (24 ng/mL) and its major metabolite nordazepam (24 ng/mL), propranolol (57 ng/mL), paliperidone (9 ng/mL), and loxapine (620 ng/mL).	Diazepam	68-76	thrombopoietin	Mus musculus	84-86
35471917-0	2022	CYP3A4*22 and CYP3A5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.	Diazepam	53-61	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
35471917-0	2022	CYP3A4*22 and CYP3A5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.	Diazepam	53-61	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	14-20
35471917-3	2022	Previous studies have shown that diazepam metabolism involves the CYP3A4 and CYP3A5 isoenzymes, whose activity is highly variable between individuals, which may contribute to differences in clinical response.	Diazepam	33-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-72
35471917-3	2022	Previous studies have shown that diazepam metabolism involves the CYP3A4 and CYP3A5 isoenzymes, whose activity is highly variable between individuals, which may contribute to differences in clinical response.	Diazepam	33-41	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	77-83
35471917-4	2022	PURPOSE: The study aimed to investigate the effects of the genetic polymorphisms CYP3A4*22 and CYP3A5*3 on the efficacy and safety of diazepam in patients with AWS.	Diazepam	134-142	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
35471917-4	2022	PURPOSE: The study aimed to investigate the effects of the genetic polymorphisms CYP3A4*22 and CYP3A5*3 on the efficacy and safety of diazepam in patients with AWS.	Diazepam	134-142	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	95-101
35471917-8	2022	RESULTS: Patients who carry CT and TT genotypes by polymorphic marker C > T intron 6 (rs35599367) of the CYP3A4 gene had a higher risk for ADR and demonstrated lower safety of diazepam therapy (p < 0.001; two-way ANOVA).	Diazepam	176-184	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-111
35399296-6	2022	Cyclin D1 (Ccnd1), a gene both causally linked to and sufficient to infer regenerative proliferation activity, was overexpressed after exposures to carbon tetrachloride, aflatoxin B1 and thioacetamide, but not in exposures to diazepam and simvastatin.	Diazepam	226-234	cyclin D1	Rattus norvegicus	0-9
35001019-3	2022	Previous studies have shown that the metabolism of diazepam involves the CYP2C19 isoenzyme, whose activity is highly dependent on polymorphism of the encoding gene.	Diazepam	51-59	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	73-80
35001019-4	2022	OBJECTIVE: The study aimed to investigate the effects of CYP2C19*17 genetic polymorphisms on plasma and saliva concentrations of diazepam as well as its impact on the efficacy and safety rates of therapy in patients with AWS.	Diazepam	129-137	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	57-64
35001019-10	2022	CONCLUSION: Our study showed the effects of CYP2C19*17 genetic polymorphisms on the efficacy and safety rates of diazepam.	Diazepam	113-121	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	44-51
35399296-6	2022	Cyclin D1 (Ccnd1), a gene both causally linked to and sufficient to infer regenerative proliferation activity, was overexpressed after exposures to carbon tetrachloride, aflatoxin B1 and thioacetamide, but not in exposures to diazepam and simvastatin.	Diazepam	226-234	cyclin D1	Rattus norvegicus	11-16
2794052-6	1989	The absence of albumin in the latter increased the unbound fraction of diazepam by almost fivefold; however, in both groups, the ratio of unbound concentrations in brain and blood at equilibrium was equal to unity.	Diazepam	71-79	albumin	Rattus norvegicus	15-22
35049799-10	2022	Diazepam-treated mice showed lower Tbody and Tsc, consistent with reduced anxiety.	Diazepam	0-8	TSC22 domain family, member 1	Mus musculus	45-48
35228700-0	2022	Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).	Diazepam	10-18	translocator protein	Mus musculus	129-149
35228700-0	2022	Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).	Diazepam	10-18	translocator protein	Mus musculus	151-155
35228700-5	2022	Diazepam induces these deficits via the mitochondrial 18 kDa translocator protein (TSPO), rather than classical gamma-aminobutyric acid type A receptors, which alters microglial morphology, and phagocytosis of synaptic material.	Diazepam	0-8	translocator protein	Mus musculus	61-81
35228700-5	2022	Diazepam induces these deficits via the mitochondrial 18 kDa translocator protein (TSPO), rather than classical gamma-aminobutyric acid type A receptors, which alters microglial morphology, and phagocytosis of synaptic material.	Diazepam	0-8	translocator protein	Mus musculus	83-87
2615592-1	1989	Previous studies suggest that a diazepam binding inhibitor (DBI, also referred to as endozepine) present in the brain may function anxiogenically as a modulator of the gamma-aminobutyric acid receptor complex (GABAA).	Diazepam	32-40	diazepam binding inhibitor	Mus musculus	60-63
2615592-1	1989	Previous studies suggest that a diazepam binding inhibitor (DBI, also referred to as endozepine) present in the brain may function anxiogenically as a modulator of the gamma-aminobutyric acid receptor complex (GABAA).	Diazepam	32-40	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	210-215
2544879-8	1989	In this report, we show that the prototypic benzodiazepine, diazepam, effects a stimulation of adrenal mitochondrial cholesterol delivery similar to that observed for endozepine.	Diazepam	60-68	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	167-177
2553994-8	1989	The induction of c-fos by Metrazole is blocked or attenuated by known anticonvulsants such as diazepam and valproate as well as the N-methyl-D-aspartate (NMDA) receptor antagonists, 2-amino-5-phosphonovaleric acid (APV) and MK-801.	Diazepam	94-102	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
2544879-10	1989	The action of diazepam in adrenal mitochondria suggests that the mediation of corticotropin-induced steroidogenesis may be the physiological function of the peripheral-type benzodiazepine receptor.	Diazepam	14-22	translocator protein	Bos taurus	157-196
2540886-0	1989	Diazepam inhibits calcium, calmodulin-dependent protein kinase in primary astrocyte cultures.	Diazepam	0-8	calmodulin 1	Rattus norvegicus	27-37
2540886-1	1989	The effect of the anticonvulsants diazepam, phenytoin, and valproic acid on calcium, calmodulin-dependent protein phosphorylation in astrocytes was investigated.	Diazepam	34-42	calmodulin 1	Rattus norvegicus	85-95
2540886-6	1989	These results indicate that diazepam is capable of inhibiting calcium, calmodulin-dependent protein kinase activity in astrocytes, thereby suggesting a possible site of diazepam action and a potential mechanism for a role of astrocytes in epileptogenesis.	Diazepam	28-36	calmodulin 1	Rattus norvegicus	71-81
2540886-2	1989	We found that diazepam inhibited calcium, calmodulin-stimulated phosphorylation in both supernatant and membrane fractions from primary cultures of rat astrocytes, whereas phenytoin and valproic acid (50-500 microM) had little to no effect.	Diazepam	14-22	calmodulin 1	Rattus norvegicus	42-52
2540886-6	1989	These results indicate that diazepam is capable of inhibiting calcium, calmodulin-dependent protein kinase activity in astrocytes, thereby suggesting a possible site of diazepam action and a potential mechanism for a role of astrocytes in epileptogenesis.	Diazepam	169-177	calmodulin 1	Rattus norvegicus	71-81
2786170-9	1989	In the "inside-out" configuration, the addition of DZP activated GABA-receptor ionophore complexes under subthreshold without changing the single Cl- channel conductance.	Diazepam	51-54	GABA type A receptor-associated protein	Homo sapiens	65-78
2494906-4	1989	Finally, patients in whom the duration of sedation with diazepam was shorter (78 +/- 14 minutes) had a significantly greater decrease in the slope of their hypoxic ventilatory response curve (1.3 +/- 0.8 L.min-1.%sat-1 [-43% from baseline]) than did patients with longer sedation times (145 +/- 37 minutes duration; 2.0 +/- 0.8 L.min-1.%sat-1 [-5% from baseline]).	Diazepam	56-64	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	213-218
2494906-4	1989	Finally, patients in whom the duration of sedation with diazepam was shorter (78 +/- 14 minutes) had a significantly greater decrease in the slope of their hypoxic ventilatory response curve (1.3 +/- 0.8 L.min-1.%sat-1 [-43% from baseline]) than did patients with longer sedation times (145 +/- 37 minutes duration; 2.0 +/- 0.8 L.min-1.%sat-1 [-5% from baseline]).	Diazepam	56-64	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	337-342
2550216-3	1989	Phenobarbital (PB) and the benzodiazepines (BZDs), diazepam (DZP), clonazepam (CZP), and lorazepam (LZP), also reduced SRF, but only at supratherapeutic free serum concentrations achieved in treatment of generalized tonic-clonic status epilepticus.	Diazepam	51-59	serum response factor	Mus musculus	119-122
2495841-9	1989	In addition, increases in ODC-controlled polyamine synthesis in nerve cells may play a significant role in the pathophysiology of the reversible neuronal dysfunction, e.g. diazepam-sensitive seizure-like activity, enhanced glucose utilization, evoked by the intracarotid infusion of hyperosmolal mannitol.	Diazepam	172-180	ornithine decarboxylase 1	Homo sapiens	26-29
2553044-1	1989	We examined the effects of chronic treatment with antidepressants (imipramine or desipramine) or benzodiazepines (diazepam, alprazolam, or adinazolam) on modulation of corticotropin-releasing-factor (CRF) receptors in discrete areas of rat brain and in anterior pituitary.	Diazepam	114-122	corticotropin releasing hormone	Rattus norvegicus	168-198
2492934-4	1989	Treatment with phenytoin resulted in a significant increase in growth hormone release after diazepam and glucagon, whilst sodium valproate reduced the growth hormone response to diazepam.	Diazepam	178-186	growth hormone 1	Homo sapiens	151-165
2533802-15	1989	NCR impairment was observed only after application of ethanol with diazepam.	Diazepam	67-75	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	0-3
2492934-0	1989	Growth hormone response to diazepam, clonidine and glucagon in patients with epilepsy.	Diazepam	27-35	growth hormone 1	Homo sapiens	0-14
2492934-3	1989	There was a reduction in growth hormone response to diazepam in both treated and untreated patients with epilepsy compared to controls.	Diazepam	52-60	growth hormone 1	Homo sapiens	25-39
2492934-4	1989	Treatment with phenytoin resulted in a significant increase in growth hormone release after diazepam and glucagon, whilst sodium valproate reduced the growth hormone response to diazepam.	Diazepam	92-100	growth hormone 1	Homo sapiens	63-77
2550216-3	1989	Phenobarbital (PB) and the benzodiazepines (BZDs), diazepam (DZP), clonazepam (CZP), and lorazepam (LZP), also reduced SRF, but only at supratherapeutic free serum concentrations achieved in treatment of generalized tonic-clonic status epilepticus.	Diazepam	61-64	serum response factor	Mus musculus	119-122
3199597-5	1988	CCK8 (1 microgram/mouse) markedly stimulated the 2-DG uptake in neurons in the various regions of the brain, but the stimulative effects of CCK8 was almost completely suppressed after an intraperitoneal administration of 1.0 mg/kg of DZP or 0.5 mg/kg of ATM.	Diazepam	234-237	cholecystokinin	Mus musculus	0-4
3063133-2	1988	Both diazepam and thiopental, commonly used agents for inducing anaesthesia, show some typical neuroendocrine effects such as liberation of human growth hormone (hGH) in addition to their well-known influences on the cardiovascular system.	Diazepam	5-13	growth hormone 1	Homo sapiens	146-160
3210041-0	1988	Diazepam binding inhibitor-like immunoreactivity (DBI-LI) in human CSF.	Diazepam	0-8	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	50-53
3210041-2	1988	Cerebrospinal fluid (CSF) levels of the anxiogenic neuropeptide diazepam binding inhibitor (DBI) were determined by radioimmunoassay in 281 patients who underwent evaluation for neurological problems.	Diazepam	64-72	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	92-95
3199597-5	1988	CCK8 (1 microgram/mouse) markedly stimulated the 2-DG uptake in neurons in the various regions of the brain, but the stimulative effects of CCK8 was almost completely suppressed after an intraperitoneal administration of 1.0 mg/kg of DZP or 0.5 mg/kg of ATM.	Diazepam	234-237	cholecystokinin	Mus musculus	140-144
3199597-6	1988	Since it has been previously shown that these doses of DZP and ATM almost completely reversed the antinociception produced by 1 microgram/mouse of CCK8, the present results on the 2-DG uptake in the mouse brain are considered to further support the antagonism between CCK8 and DZP or ATM in the central nervous system.	Diazepam	55-58	cholecystokinin	Mus musculus	147-151
3199597-6	1988	Since it has been previously shown that these doses of DZP and ATM almost completely reversed the antinociception produced by 1 microgram/mouse of CCK8, the present results on the 2-DG uptake in the mouse brain are considered to further support the antagonism between CCK8 and DZP or ATM in the central nervous system.	Diazepam	55-58	cholecystokinin	Mus musculus	268-272
3199597-6	1988	Since it has been previously shown that these doses of DZP and ATM almost completely reversed the antinociception produced by 1 microgram/mouse of CCK8, the present results on the 2-DG uptake in the mouse brain are considered to further support the antagonism between CCK8 and DZP or ATM in the central nervous system.	Diazepam	277-280	cholecystokinin	Mus musculus	147-151
3377952-2	1988	The impact of anaesthetic-induced action on enzyme activity and diazepam binding to human serum albumin (HSA) was assessed in protein free and protein containing buffers, respectively.	Diazepam	64-72	albumin	Rattus norvegicus	90-103
3413133-1	1988	Diazepam binding inhibitor (DBI), an endogenous 10-kDa polypeptide was isolated from rat and human brain by monitoring displacement of radioactive diazepam bound to specific recognition sites in brain synaptic and mitochondrial membranes.	Diazepam	147-155	diazepam binding inhibitor	Rattus norvegicus	0-32
3171600-1	1988	To verify the potential in vivo inhibitory effect on liver function of tumor necrosis factor (TNF), also known as cachectin, antipyrine and diazepam were chosen to probe the hepatic mixed-function oxidase system.	Diazepam	140-148	tumor necrosis factor-like	Rattus norvegicus	94-97
3171600-2	1988	A single dose of TNF (30 micrograms/kg) to rats significantly reduced the plasma clearance of antipyrine and diazepam by about 30% and 25%, respectively; this resulted in concomitant prolongation of the elimination half-life (t1/2) of the two drugs, although of borderline significance for the benzodiazepine.	Diazepam	109-117	tumor necrosis factor-like	Rattus norvegicus	17-20
3171600-3	1988	This was probably due to a decrease in hepatic cytochrome P-450 activities that are responsible for antipyrine and diazepam metabolism in TNF-treated rats.	Diazepam	115-123	tumor necrosis factor-like	Rattus norvegicus	138-141
3392659-4	1988	The order of potency in antagonizing the 1.0 mg/kg training dose of diazepam was beta CCtB greater than beta CCM greater than beta CCE much greater than 3 HMC.	Diazepam	68-76	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	86-90
3392659-6	1988	beta CCE and beta CCtB produced dose-related, parallel shifts in the dose-response curve for the discriminative effects of diazepam, but the magnitude of the shifts was limited: the two highest doses of beta CCE and beta CCtB produced shifts that were not significantly different in magnitude.	Diazepam	123-131	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	18-22
2901360-2	1988	A two-week treatment with either diazepam (5 mg/kg per day) or flurazepam (15 mg/kg per day) markedly reduced the excitatory effect of microiontophoretically applied sulphated cholecystokinin octapeptide-(26-33) on rat CA3 hippocampal pyramidal neurons but not that of acetylcholine.	Diazepam	33-41	carbonic anhydrase 3	Rattus norvegicus	219-222
3377952-3	1988	Human serum albumin reduced the elimination of diazepam by 12 and 50% at concentrations of 1 and 10 mg ml-1, respectively.	Diazepam	47-55	albumin	Rattus norvegicus	6-19
3382734-1	1988	It has been shown that glucocorticoid receptor antagonist-cortexolone--increased anxiolytic action of diazepam in alcoholic rats.	Diazepam	102-110	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	23-46
2825044-2	1987	At the GABA-receptor complex the barbiturates inhibited the binding of [35S]t-butylbicyclophosphorothionate ([35S]TBPT) and enhanced the binding of [3H]diazepam.	Diazepam	152-160	GABA type A receptor-associated protein	Homo sapiens	7-20
2895963-0	1988	Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics.	Diazepam	57-65	histamine receptor H2	Homo sapiens	20-41
2895963-1	1988	A double-blind cross-over study of the effects of HOE 760 (histamine H2-receptor blocker) on diazepam pharmacokinetics was conducted in 12 healthy men.	Diazepam	93-101	histamine receptor H2	Homo sapiens	59-80
3124878-1	1988	The diazepam-binding behaviour of a large tryptic and a large peptic fragment of human serum albumin has been studied by circular dichroism and equilibrium dialysis in order to locate the primary diazepam-binding site on the albumin molecule.	Diazepam	4-12	albumin	Homo sapiens	87-100
3124878-1	1988	The diazepam-binding behaviour of a large tryptic and a large peptic fragment of human serum albumin has been studied by circular dichroism and equilibrium dialysis in order to locate the primary diazepam-binding site on the albumin molecule.	Diazepam	196-204	albumin	Homo sapiens	87-100
2450203-3	1988	Limitation of SRF was produced by the anticonvulsant BDZs (diazepam, clonazepam, nitrazepam and lorazepam) at low to mid nanomolar concentrations, by a convulsant BDZ which does not bind to high affinity BDZ receptors (Ro 5-4864) at high nanomolar concentrations and by a BDZ receptor weak partial agonist (Ro 15-1788) at micromolar concentrations.	Diazepam	59-67	serum response factor	Mus musculus	14-17
2450203-6	1988	The limitation of SRF by diazepam was not prevented by inverse or partial agonists at the BDZ receptor, including Ro 15-1788 and the beta CCs.	Diazepam	25-33	serum response factor	Mus musculus	18-21
3689451-4	1987	Only benzodiazepine compounds (chlordiazepoxide, diazepam and Ro 5-4864) inhibited [3H]Ro 5-4864 binding to calmodulin with inhibitory equilibrium dissociation constants (Ki) less than 10 microM.	Diazepam	49-57	calmodulin 1	Homo sapiens	108-118
2825924-0	1987	Inhibition of [3H]diazepam binding in primary cultures of astrocytes by atrial natriuretic peptide and by a cyclic GMP analog.	Diazepam	18-26	natriuretic peptide A	Homo sapiens	72-98
2825924-0	1987	Inhibition of [3H]diazepam binding in primary cultures of astrocytes by atrial natriuretic peptide and by a cyclic GMP analog.	Diazepam	18-26	5'-nucleotidase, cytosolic II	Homo sapiens	115-118
2826190-2	1987	(1) Arachidonate significantly lowered the affinity of the peripheral-type benzodiazepine receptor for R05-4864 and diazepam but did not alter the affinity for PK 11195 and only slightly altered for dipyridamole.	Diazepam	116-124	translocator protein	Rattus norvegicus	59-98
3429058-11	1987	For practical purposes, the change in the free fractions of phenytoin and diazepam can be adequately predicted by the serum creatinine or urea and serum albumin levels.	Diazepam	74-82	albumin	Homo sapiens	153-160
2833243-1	1988	The binding of oleic acid to human serum albumin causes progressive changes in (a) the pK of some amino acid residues, as detected by pH-stat titration and (b) the induced molar ellipticities of albumin-bound drugs (diazepam and oxyphenbutazone), as measured by c.d.	Diazepam	216-224	albumin	Homo sapiens	41-48
2833243-1	1988	The binding of oleic acid to human serum albumin causes progressive changes in (a) the pK of some amino acid residues, as detected by pH-stat titration and (b) the induced molar ellipticities of albumin-bound drugs (diazepam and oxyphenbutazone), as measured by c.d.	Diazepam	216-224	albumin	Homo sapiens	195-202
3129769-3	1988	On the other hand, a slight decrease of drug metabolizing enzyme activity by diazepam (DZP) but not by nitrazepam (NTZ) was enhanced by combined treatment of AMT, whereas the enhancement of UDP-GT activity by DZP or NTZ was suppressed by coadministration of AMT.	Diazepam	209-212	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	190-196
2908516-13	1988	Blunting of the growth hormone response to diazepam was the most sensitive and reliable method of detecting tolerance to the benzodiazepines.	Diazepam	43-51	growth hormone 1	Homo sapiens	16-30
3691639-8	1987	These results suggest that diazepam suppresses the spread of kainic acid-induced seizure activity from the proposed CA3 epileptogenic focus.	Diazepam	27-35	carbonic anhydrase 3	Rattus norvegicus	116-119
2820823-1	1987	The peripheral-type benzodiazepine receptor is a site identified by its nanomolar affinity for [3H]diazepam, similar to the affinity of diazepam for the central-type benzodiazepine receptor in the brain.	Diazepam	99-107	translocator protein	Homo sapiens	4-43
3670557-0	1987	Effect of a cholecystokinin antagonist on some effects of diazepam.	Diazepam	58-66	cholecystokinin	Homo sapiens	12-27
3670557-3	1987	The data presented are consistent with a role for cholecystokinin in some effects of diazepam.	Diazepam	85-93	cholecystokinin	Homo sapiens	50-65
3628621-0	1987	Diazepam alters brain 5-HT function in man: implications for the acute and chronic effects of benzodiazepines.	Diazepam	0-8	POU class 6 homeobox 1	Homo sapiens	16-23
3628621-1	1987	The effect of diazepam on brain 5-HT-mediated neuroendocrine responses was studied in healthy male volunteers.	Diazepam	14-22	POU class 6 homeobox 1	Homo sapiens	26-33
2443932-0	1987	The effects of diazepam on brain 5-HT and 5-HIAA in stressed and unstressed rats.	Diazepam	15-23	POU class 6 homeobox 1	Rattus norvegicus	27-34
3114732-0	1987	Placental and blood-CSF transfer of orally administered diazepam in the same person.	Diazepam	56-64	colony stimulating factor 2	Homo sapiens	20-23
3628621-2	1987	An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan.	Diazepam	17-25	prolactin	Homo sapiens	63-72
3628621-2	1987	An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan.	Diazepam	17-25	growth hormone 1	Homo sapiens	77-91
2821428-5	1987	Tolerance to diazepam increased the dynamic state of an octadecaneuropeptide (ODN), derived from DBI, in the cerebellum and cortex.	Diazepam	13-21	diazepam binding inhibitor	Rattus norvegicus	97-100
3114732-1	1987	Both placental and blood-lumbar CSF transfer of diazepam (5 mg orally) and its two metabolites, N-desmethyldiazepam and unconjugated oxazepam, was measured (by GLC) in 15 patients undergoing Caesarean section under spinal analgesia.	Diazepam	48-56	colony stimulating factor 2	Homo sapiens	32-35
3629520-10	1987	Despite pharmacological similarities between DAZ and phenytoin, comparison of cleft palate frequencies following administration of DAZ to various strains of mice of different H-2 haplotypes indicated that genes associated with the H-2 locus do not regulate DAZ-induced cleft palate in these strains.	Diazepam	45-48	histocompatibility-2, MHC	Mus musculus	231-234
3629520-10	1987	Despite pharmacological similarities between DAZ and phenytoin, comparison of cleft palate frequencies following administration of DAZ to various strains of mice of different H-2 haplotypes indicated that genes associated with the H-2 locus do not regulate DAZ-induced cleft palate in these strains.	Diazepam	131-134	histocompatibility-2, MHC	Mus musculus	231-234
3629520-10	1987	Despite pharmacological similarities between DAZ and phenytoin, comparison of cleft palate frequencies following administration of DAZ to various strains of mice of different H-2 haplotypes indicated that genes associated with the H-2 locus do not regulate DAZ-induced cleft palate in these strains.	Diazepam	131-134	histocompatibility-2, MHC	Mus musculus	231-234
3036301-6	1987	Ro 15-1788 blocked the decreases both in inactivity and in plasma ACTH and cortisol concentrations caused by diazepam, suggesting that these effects are mediated through benzodiazepine receptors.	Diazepam	109-117	proopiomelanocortin	Homo sapiens	66-70
3555508-8	1987	The GABA transaminase inhibition method resulted in a 27% and a 17% decrease in GABA turnover for diazepam and morphine respectively.	Diazepam	98-106	4-aminobutyrate aminotransferase	Rattus norvegicus	4-21
3593949-1	1987	The influence of ACTH (200 micrograms/kg), corticosterone (20 mg/kg) and cortexolone (20 mg/kg) on the anxiolytic activity of diazepam was studied.	Diazepam	126-134	proopiomelanocortin	Homo sapiens	17-21
3593949-2	1987	ACTH partly and corticosterone completely blocked the action of diazepam.	Diazepam	64-72	proopiomelanocortin	Homo sapiens	0-4
3023221-0	1986	Evidence for the involvement of the opiate-receptors in the diazepam-induced human growth hormone secretion.	Diazepam	60-68	growth hormone 1	Homo sapiens	83-97
2883283-4	1987	The displacement study showed that tolmetin caused a significant increase in the affinity of diazepam to HSA whereas it decreased the binding of warfarin to HSA.	Diazepam	93-101	albumin	Homo sapiens	105-108
3474983-5	1987	The activity of hypothalamic glutamate decarboxylase, the enzyme taking part in GABA synthesis, was affected neither by the acute nor by repeated stress and/or diazepam treatment.	Diazepam	160-168	glutamate-ammonia ligase	Rattus norvegicus	29-52
2836493-1	1987	Diazepam (DZP) inhibited in vitro in a concentration-dependent manner superoxide anion generation and chemiluminescence from human neutrophils stimulated by the formylated oligopeptide FMLP and by the calcium ionophore A23187.	Diazepam	0-8	formyl peptide receptor 1	Homo sapiens	185-189
2836493-1	1987	Diazepam (DZP) inhibited in vitro in a concentration-dependent manner superoxide anion generation and chemiluminescence from human neutrophils stimulated by the formylated oligopeptide FMLP and by the calcium ionophore A23187.	Diazepam	10-13	formyl peptide receptor 1	Homo sapiens	185-189
3023014-1	1986	The perifusion technique was used to investigate the action of diazepam (DZ), a benzodiazepine molecule known to compete for TRH receptor binding in rat pituitary, on TRH-induced TSH and GH release.	Diazepam	63-71	thyrotropin releasing hormone	Rattus norvegicus	125-128
3023014-1	1986	The perifusion technique was used to investigate the action of diazepam (DZ), a benzodiazepine molecule known to compete for TRH receptor binding in rat pituitary, on TRH-induced TSH and GH release.	Diazepam	63-71	thyrotropin releasing hormone	Rattus norvegicus	167-170
3023014-1	1986	The perifusion technique was used to investigate the action of diazepam (DZ), a benzodiazepine molecule known to compete for TRH receptor binding in rat pituitary, on TRH-induced TSH and GH release.	Diazepam	73-75	thyrotropin releasing hormone	Rattus norvegicus	125-128
3023014-1	1986	The perifusion technique was used to investigate the action of diazepam (DZ), a benzodiazepine molecule known to compete for TRH receptor binding in rat pituitary, on TRH-induced TSH and GH release.	Diazepam	73-75	thyrotropin releasing hormone	Rattus norvegicus	167-170
3561897-0	1987	Comparative seizure inducing properties of various cholinesterase inhibitors: antagonism by diazepam and midazolam.	Diazepam	92-100	butyrylcholinesterase	Homo sapiens	51-65
3589146-0	1987	Albumin as a potential membrane transport barrier for hepatic clearance of diazepam studied by a universal organ clearance approach.	Diazepam	75-83	albumin	Rattus norvegicus	0-7
3589146-1	1987	Published data on the effect of albumin binding on hepatic extraction of diazepam in isolated perfused rat livers were analyzed by a simple universal organ clearance approach proposed earlier by this author.	Diazepam	73-81	albumin	Rattus norvegicus	32-39
3029781-2	1987	We used a cDNA probe complementary to DBI mRNA and a specific antibody for rat DBI to study in rat brain how the dynamic state of DBI can be affected after protracted (three times a day for 10 days) treatment with diazepam and chlordiazepoxide by oral gavage.	Diazepam	214-222	diazepam binding inhibitor	Rattus norvegicus	38-41
3029781-2	1987	We used a cDNA probe complementary to DBI mRNA and a specific antibody for rat DBI to study in rat brain how the dynamic state of DBI can be affected after protracted (three times a day for 10 days) treatment with diazepam and chlordiazepoxide by oral gavage.	Diazepam	214-222	diazepam binding inhibitor	Rattus norvegicus	79-82
3029781-2	1987	We used a cDNA probe complementary to DBI mRNA and a specific antibody for rat DBI to study in rat brain how the dynamic state of DBI can be affected after protracted (three times a day for 10 days) treatment with diazepam and chlordiazepoxide by oral gavage.	Diazepam	214-222	diazepam binding inhibitor	Rattus norvegicus	79-82
20501141-4	1987	On the other hand, a marked decrease in GABA-T activity is observed during continuous treatment up to 15 days with both diazepam and oxazepam but during discontinuation phase, the decreased GABA-T activity tends to increase and attain normal value much earlier in case of oxazepam than diazepam.	Diazepam	120-128	4-aminobutyrate aminotransferase	Rattus norvegicus	40-46
20501141-4	1987	On the other hand, a marked decrease in GABA-T activity is observed during continuous treatment up to 15 days with both diazepam and oxazepam but during discontinuation phase, the decreased GABA-T activity tends to increase and attain normal value much earlier in case of oxazepam than diazepam.	Diazepam	120-128	4-aminobutyrate aminotransferase	Rattus norvegicus	190-196
20501141-4	1987	On the other hand, a marked decrease in GABA-T activity is observed during continuous treatment up to 15 days with both diazepam and oxazepam but during discontinuation phase, the decreased GABA-T activity tends to increase and attain normal value much earlier in case of oxazepam than diazepam.	Diazepam	286-294	4-aminobutyrate aminotransferase	Rattus norvegicus	40-46
20501141-4	1987	On the other hand, a marked decrease in GABA-T activity is observed during continuous treatment up to 15 days with both diazepam and oxazepam but during discontinuation phase, the decreased GABA-T activity tends to increase and attain normal value much earlier in case of oxazepam than diazepam.	Diazepam	286-294	4-aminobutyrate aminotransferase	Rattus norvegicus	190-196
2873849-1	1986	Phenazepam (5 mg/200 g) and seduxen (3 mg/200 g) injected intraperitoneally to 184 rats altered AMP-deaminase and adenosine deaminase brain activity.	Diazepam	28-35	adenosine deaminase	Rattus norvegicus	114-133
3731680-0	1986	Naloxone, fentanyl, and diazepam modify plasma beta-endorphin levels during surgery.	Diazepam	24-32	proopiomelanocortin	Homo sapiens	47-61
2873849-2	1986	Seduxen was observed to increase AMP-deaminase and adenosine deaminase activity by 89.1% and 32.4%, respectively an hour after the injection.	Diazepam	0-7	adenosine deaminase	Rattus norvegicus	51-70
2873044-6	1986	Higher concentration of the same drugs and diazepam (1 and 10 microM) which has high affinity for benzodiazepine receptors on gastrointestinal muscle, inhibited responses of ileum and gall-bladder to both CCK and acetylcholine.	Diazepam	43-51	cholecystokinin	Rattus norvegicus	205-208
2871819-2	1986	Diazepam administration (4.4 to 140 micrograms/kg, cumulative dose) resulted in a dose-dependent decrease in saccadic eye velocity and plasma cortisol level as well as a dose-dependent increase in self-rated sedation and plasma growth hormone level.	Diazepam	0-8	growth hormone 1	Homo sapiens	228-242
2871819-4	1986	The diazepam-induced changes in saccadic eye velocity, sedation, and growth hormone and cortisol levels were highly correlated with each other and with increasing plasma diazepam concentration.	Diazepam	4-12	growth hormone 1	Homo sapiens	69-83
2871819-4	1986	The diazepam-induced changes in saccadic eye velocity, sedation, and growth hormone and cortisol levels were highly correlated with each other and with increasing plasma diazepam concentration.	Diazepam	170-178	growth hormone 1	Homo sapiens	69-83
3698206-3	1986	Both diazepam and oxazepam induced hepatomegaly, cytochrome P-450 and cytochrome P-450-dependent aminopyrine N-demethylase activity in hepatocytes, effects similar to those produced by a well-known rodent liver tumor promoter, phenobarbital.	Diazepam	5-13	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	49-122
3703887-2	1986	However, a small but significant decrease in hypothalamic HA concentration and significantly increased HD activity was seen following diazepam withdrawal.	Diazepam	134-142	histidine decarboxylase	Rattus norvegicus	103-105
2871466-4	1986	In line with these findings, diazepam was found to induce GH release in reserpine pretreated rats only when the alpha 2-receptor agonist clonidine was simultaneously administered.	Diazepam	29-37	gonadotropin releasing hormone receptor	Rattus norvegicus	58-60
3485990-3	1986	The results are further evidence that the previously reported prolongation of the half-life of diazepam by omeprazole in vivo is due to inhibition of cytochrome P-450 monooxygenases.	Diazepam	95-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-166
3027601-2	1986	Therefore, the present study investigated the effects, in the same healthy subjects, of sodium valproate or diazepam, on both basal and stress-stimulated concentrations of beta-endorphin (beta-EP), beta-lipotropin (beta-LPH) and cortisol.	Diazepam	108-116	proopiomelanocortin	Homo sapiens	172-186
3484995-15	1986	AVP-induced BR in sensitized rats: phenytoin, diazepam, valproic acid and phenobarbital; all drugs reduced the proportion of rats with BR and prolonged the latency.	Diazepam	46-54	arginine vasopressin	Rattus norvegicus	0-3
3950058-3	1986	For the drugs that bind predominantly to albumin, the serum free fractions were greater in patients one week after the burn incident than in control subjects (diazepam, 0.055 vs. 0.017; phenytoin, 0.24 vs. 0.16; and salicylic acid, 0.69 vs. 0.32).	Diazepam	159-167	albumin	Homo sapiens	41-48
3456171-0	1986	Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.	Diazepam	46-54	diazepam binding inhibitor	Rattus norvegicus	74-77
3456171-1	1986	An endogenous brain neuropeptide with 104 amino acid residues that modulates gamma-aminobutyric acid receptor function was termed DBI because it displaces diazepam from its specific brain binding sites.	Diazepam	155-163	diazepam binding inhibitor	Rattus norvegicus	130-133
2876582-0	1986	Effect of diazepam and medazepam on prolactin secretion.	Diazepam	10-18	prolactin	Rattus norvegicus	36-45
2876582-1	1986	Pharmacological studies of the effect of Diazepam and Medazepam on prolactin secretion were carried out on sexually mature male albino rats.	Diazepam	41-49	prolactin	Rattus norvegicus	67-76
2876582-6	1986	Prolactin secretion decreases after a single intraperitoneal administration of Diazepam in both doses.	Diazepam	79-87	prolactin	Rattus norvegicus	0-9
3027601-4	1986	On the other hand, in the same subjects, pretreatment with sodium valproate (20 mg X 3) or diazepam (10 mg X 2) blocked the increases in these hormones produced by hypoglycemic stress in all patients tested (p less than 0.01 vs. placebo at 45, 60 and 90 min after insulin injection), without affecting the decrease in blood glucose levels.	Diazepam	91-99	insulin	Homo sapiens	264-271
2869533-1	1986	Three benzodiazepines, chlordiazepoxide, diazepam and flurazepam, were demonstrated to reverse the suppressed food intake in mice in response to cholecystokinin octapeptide (CCK8).	Diazepam	41-49	cholecystokinin	Mus musculus	145-160
3027601-5	1986	The present data show that sodium valproate and diazepam inhibit stress-induced beta-EP, beta-LPH and cortisol secretion in humans, suggesting that endogenous GABA and benzodiazepine receptors participate in physiological mechanisms regulating the activity of the HPA axis.	Diazepam	48-56	proopiomelanocortin	Homo sapiens	80-87
3027601-5	1986	The present data show that sodium valproate and diazepam inhibit stress-induced beta-EP, beta-LPH and cortisol secretion in humans, suggesting that endogenous GABA and benzodiazepine receptors participate in physiological mechanisms regulating the activity of the HPA axis.	Diazepam	48-56	proopiomelanocortin	Homo sapiens	89-97
4079340-1	1985	Radioactive methadone, phenytoin, phenobarbital, and diazepam were easily and efficiently removed from human urine samples by adsorption on C18 bonded silica phases.	Diazepam	53-61	Bardet-Biedl syndrome 9	Homo sapiens	140-143
3714907-0	1986	Maternal diazepam exposure on brain ornithine decarboxylase and growth of offspring.	Diazepam	9-17	ornithine decarboxylase 1	Homo sapiens	36-59
3714907-1	1986	The prenatal treatment of diazepam on the developmental pattern of brain ornithine decarboxylase and the general growth of offspring were studied.	Diazepam	26-34	ornithine decarboxylase 1	Homo sapiens	73-96
3714907-4	1986	It was found that diazepam inhibited both the prenatal and 4-hour postnatal ornithine decarboxylase activities, though the general maturation pattern of the enzyme in the brain was not much altered.	Diazepam	18-26	ornithine decarboxylase 1	Homo sapiens	76-99
2954317-0	1986	The effect of diazepam and chlorpromazine on the activity of ATPase in mice neocortex and hippocampal formation.	Diazepam	14-22	dynein, axonemal, heavy chain 8	Mus musculus	61-67
3834411-6	1985	The two octapeptides only slightly modified the activity of diazepam: CCK-8-SE pretreatment displayed a tendency to antagonize it, while CCK-8-NS pretreatment to potentiate it.	Diazepam	60-68	cholecystokinin	Mus musculus	70-73
3834411-6	1985	The two octapeptides only slightly modified the activity of diazepam: CCK-8-SE pretreatment displayed a tendency to antagonize it, while CCK-8-NS pretreatment to potentiate it.	Diazepam	60-68	cholecystokinin	Mus musculus	137-140
3865740-0	1985	Effect of thiamylal and diazepam on release of myoglobin and creatine phosphokinase by succinylcholine chloride during halothane anesthesia.	Diazepam	24-32	myoglobin	Homo sapiens	47-56
2864965-1	1985	Experiments on 330 rats were made to study the influence of benzodiazepines (diazepam, dormicum and phenazepam) on 5"-nucleotidase activity in brain homogenates.	Diazepam	77-85	5' nucleotidase, ecto	Rattus norvegicus	115-130
2868142-1	1985	The contractile response of the guinea-pig gallbladder to cholecystokinin (CCK) and acetylcholine (ACh) was irreversibly inhibited by 5 X 10(-5) M dibenamine, and the dibenamine-induced inhibition in the CCK response was prevented by 10(-4) M chlordiazepoxide (CDP) and diazepam (DZP), but not by 10(-2) M proglumide or 10(-6) M atropine.	Diazepam	270-278	cholecystokinin	Cavia porcellus	58-73
2868142-1	1985	The contractile response of the guinea-pig gallbladder to cholecystokinin (CCK) and acetylcholine (ACh) was irreversibly inhibited by 5 X 10(-5) M dibenamine, and the dibenamine-induced inhibition in the CCK response was prevented by 10(-4) M chlordiazepoxide (CDP) and diazepam (DZP), but not by 10(-2) M proglumide or 10(-6) M atropine.	Diazepam	270-278	cholecystokinin	Cavia porcellus	75-78
2868142-1	1985	The contractile response of the guinea-pig gallbladder to cholecystokinin (CCK) and acetylcholine (ACh) was irreversibly inhibited by 5 X 10(-5) M dibenamine, and the dibenamine-induced inhibition in the CCK response was prevented by 10(-4) M chlordiazepoxide (CDP) and diazepam (DZP), but not by 10(-2) M proglumide or 10(-6) M atropine.	Diazepam	280-283	cholecystokinin	Cavia porcellus	58-73
2868142-1	1985	The contractile response of the guinea-pig gallbladder to cholecystokinin (CCK) and acetylcholine (ACh) was irreversibly inhibited by 5 X 10(-5) M dibenamine, and the dibenamine-induced inhibition in the CCK response was prevented by 10(-4) M chlordiazepoxide (CDP) and diazepam (DZP), but not by 10(-2) M proglumide or 10(-6) M atropine.	Diazepam	280-283	cholecystokinin	Cavia porcellus	75-78
2868143-1	1985	Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered intraperitoneally.	Diazepam	191-199	cholecystokinin	Mus musculus	30-45
2864965-2	1985	It was discovered that diazepam and dormicum in doses of 3 and 4 mg, phenazepam in doses of 3.75 and 5 mg per 200 g bw provoked a 16-20% reduction in 5"-nucleotidase activity.	Diazepam	23-31	5' nucleotidase, ecto	Rattus norvegicus	150-165
3865740-1	1985	The effects of thiamylal and diazepam on the release of myoglobin and creatine phosphokinase following the administration of succinylcholine chloride during halothane anesthesia were studied.	Diazepam	29-37	myoglobin	Homo sapiens	56-65
2858996-5	1985	These drugs added a depressant effect to diazepam (13.83% fall in SI and 15.77% increase in PEP/LVET) without increasing Althesin"s negative inotropic effect.	Diazepam	41-49	progestagen associated endometrial protein	Homo sapiens	92-95
3978310-3	1985	HACU was inhibited by drugs which have in common the ability to facilitate gamma-aminobutyric acid (GABA) transmission, pentobarbitone, phenobarbitone, barbitone, diazepam, chloridiazepoxide, and valproic acid.	Diazepam	163-171	high affinity choline uptake	Mus musculus	0-4
4092617-2	1985	Phenoxybenzamine (1-6 mg/kg), diazepam (0.625 and 1.25 mg/kg) and pilocarpine (2.5 and 5 mg/kg) significantly decreased (or abolished) the occurrence of atropine and 2-PAM stressed-induced convulsions and/or lethality.	Diazepam	30-38	peptidylglycine alpha-amidating monooxygenase	Mus musculus	168-171
3989694-3	1985	Specifically, data related to diazepam (E = 0.95 at fub = 1) clearly conformed to the predictions of the sinusoidal perfusion model and differed markedly from those of the venous equilibrium model.	Diazepam	30-38	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	52-59
6152472-5	1984	Chlordiazepoxide, diazepam and muscimol inhibited FTA-induced abnormal behaviors.	Diazepam	18-26	farnesyltransferase, CAAX box, alpha	Mus musculus	50-53
3984510-1	1985	Intramuscular injections of seduxen (10 mg), a benzodiasepin drug, with expressed tranquilizing and alarm suppressing effects, were used with the aim of experimental testing of a hypothesis on the neural mechanism of conditioned changes of the P300 wave.	Diazepam	28-35	E1A binding protein p300	Homo sapiens	244-248
6481217-1	1984	Cimetidine interaction with cytochrome P-450 may reduce binding affinity of some drugs, causing reduced metabolism of substrates such as diazepam and warfarin.	Diazepam	137-145	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	28-44
6150837-6	1984	It is suggested that the diminished consumption of ethanol and diazepam as caused by GABA-T-inhibition may also be mediated by dopamine which seems to act indirectly, via benzodiazepine receptors and GABA neurons.	Diazepam	63-71	4-aminobutyrate aminotransferase	Rattus norvegicus	85-91
6096760-12	1984	Diazepam, 20 micrograms i.t., reduced activity evoked by afferent A delta and C fiber stimulation and by stimulation of afferent A beta fibers.	Diazepam	0-8	amyloid beta precursor protein	Rattus norvegicus	129-135
6094935-1	1984	The effectiveness of beta-carboline-3-carboxylate-t-butyl ester (beta CCtB) in antagonizing the anticonvulsant, ataxic and antipunishment effects of diazepam were evaluated.	Diazepam	149-157	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	70-74
6094935-2	1984	In mice, beta CCtB at doses of 3 and 10 mg/kg produced a dose-related antagonism of the anticonvulsant effects of diazepam against pentylenetetrazole (80 mg/kg).	Diazepam	114-122	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	14-18
6094935-8	1984	beta CCtB had no effect on response rates when administered alone, but antagonized the rate-increasing effects of diazepam in the punished component.	Diazepam	114-122	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	5-9
6089614-0	1984	Plasma beta-endorphin levels in oral surgery patients following diazepam, fentanyl or placebo.	Diazepam	64-72	proopiomelanocortin	Homo sapiens	7-21
6149902-6	1984	However, if the bovine serum albumin was omitted from the perfusate, diazepam uptake in the IPL increased about 10-fold while methadone uptake increased only slightly.	Diazepam	69-77	albumin	Rattus norvegicus	23-36
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Diazepam	51-59	thyrotropin releasing hormone	Homo sapiens	119-148
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Diazepam	51-59	thyrotropin releasing hormone	Homo sapiens	150-153
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Diazepam	61-64	thyrotropin releasing hormone	Homo sapiens	119-148
6146660-1	1984	The benzodiazepines (BZDs) chlordiazepoxide (CDE), diazepam (DZM), and flurazepam (FLM) inhibited receptor binding for thyrotropin-releasing hormone (TRH) with low micromolar potency.	Diazepam	61-64	thyrotropin releasing hormone	Homo sapiens	150-153
6152301-5	1984	Following induction of anesthesia by diazepam-vecuronium-fentanyl sequence, there was a decrease in SBP by 20.0% (P less than 0.05), in HR by 15.7% (P less than 0.001) in C.O by 13.3% (P less than 0.01) and in SVR by 13.6% (P less than 0.05) of control value.	Diazepam	37-45	selenium binding protein 1	Homo sapiens	100-103
6089614-2	1984	Diazepam and fentanyl blocked the stress induced increase in plasma beta-endorphin experienced by patients administered placebo.	Diazepam	0-8	proopiomelanocortin	Homo sapiens	68-82
6325210-3	1984	Both Trp-P-1 and Trp-P-2 inhibited the specific binding of [3H]diazepam and [3H]muscimol in rat brain membranes mainly by increasing Kd, indicating that these gamma-carbolines bind on benzodiazepine and GABA receptors.	Diazepam	63-71	polycystin 2, transient receptor potential cation channel	Rattus norvegicus	17-24
6326115-7	1984	Since the diazepam-induced increase of [3H]muscimol binding is paralleled by a significant potentiation of the inhibitory effect of muscimol on locomotor activity, it is proposed that the facilitatory action on GABAergic transmission elicited in vivo by diazepam is mediated by an increase in the Bmax of the binding sites of GABAA receptors.	Diazepam	10-18	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	326-331
6425492-5	1984	The volumes of distribution (Vd beta) were calculated as model-independent parameters for diazepam and nordiazepam.	Diazepam	90-98	GC vitamin D binding protein	Homo sapiens	29-36
6705453-1	1984	Plasma protein binding in seven severely burned (35% to 85% of body) patients 1 to 25 days after burn injury was examined for two drugs: diazepam (DZ), which binds mainly to serum albumin (ALB), and imipramine (IMI), which binds primarily to alpha 1-acid glycoprotein (AAG).	Diazepam	147-149	albumin	Homo sapiens	180-187
6712779-0	1984	Diazepam inhibits cholesterol esterification by arterial ACAT and plasma LCAT, in vitro.	Diazepam	0-8	sterol O-acyltransferase 1	Oryctolagus cuniculus	57-61
6712779-0	1984	Diazepam inhibits cholesterol esterification by arterial ACAT and plasma LCAT, in vitro.	Diazepam	0-8	phosphatidylcholine-sterol acyltransferase	Oryctolagus cuniculus	73-77
6712779-3	1984	The studies presented here indicate that diazepam, the most widely used benzodiazepine, is an inhibitor of cholesterol esterification by ACAT in vitro in atheromatous rabbit aortas, in microsomes isolated from atheromatous rabbit aortas, and in normal rat aortas.	Diazepam	41-49	sterol O-acyltransferase 1	Oryctolagus cuniculus	137-141
6712779-4	1984	Diazepam also inhibited LCAT in plasma from man, monkey, rabbit, and rat, in vitro.	Diazepam	0-8	lecithin-cholesterol acyltransferase	Homo sapiens	24-28
6429560-5	1984	Diazepam had no effect on GABA level and GAD activity, whereas it caused a slight inhibition of GABA-T activity.	Diazepam	0-8	4-aminobutyrate aminotransferase	Homo sapiens	96-102
6712355-3	1984	A highly significant linear relationship was found between regional diazepam resp. chlorpromazine concentration, and regional cerebral blood flow (rCBF) 1 min after injection.	Diazepam	68-76	CCAAT/enhancer binding protein zeta	Rattus norvegicus	147-151
6712355-4	1984	Moreover, a linear relationship was found between rCBF and, on the other hand, firstly diazepam concentration decrease between 1 and 2 min, secondly increase in chlorpromazine concentration between 1 and 5 min, and finally decrease of chlorpromazine concentration between 5 and 30 min.	Diazepam	87-95	CCAAT/enhancer binding protein zeta	Rattus norvegicus	50-54
6319933-3	1984	Diazepam has been reported to inhibit both the tremor and mechanism of cerebellar cyclic GMP caused by harmaline by a neurotransmission in the cerebellum.	Diazepam	0-8	5'-nucleotidase, cytosolic II	Homo sapiens	89-92
6320963-2	1984	We investigated whether the inhibition of PRL secretion by the benzodiazepine receptor agonist, diazepam, occurs directly at the pituitary.	Diazepam	96-104	prolactin	Rattus norvegicus	42-45
6320963-3	1984	At nanomolar concentrations diazepam did not affect PRL secretion, whereas at micromolar concentrations, diazepam dose-dependently inhibited basal and secretagogue-stimulated PRL release from hemipituitary glands and from primary cultures of rat anterior pituitary cells.	Diazepam	105-113	prolactin	Rattus norvegicus	175-178
6320963-5	1984	Although nanomolar concentrations of diazepam alone did not affect PRL release, they did enhance the PRL inhibitory effect of muscimol, a gamma-amino butyric acid (GABA) receptor agonist.	Diazepam	37-45	prolactin	Rattus norvegicus	101-104
6320963-7	1984	Since these effects do not appear to occur through an inhibition of the cAMP generating system, diazepam may inhibit PRL release via a cAMP-independent pathway.	Diazepam	96-104	prolactin	Rattus norvegicus	117-120
6320963-8	1984	We suggest that diazepam inhibits PRL secretion either by enhancing the GABAergic inhibition of PRL release, or by inhibiting, at micromolar concentrations, a benzodiazepine-sensitive Ca2+-calmodulin dependent protein kinase.	Diazepam	16-24	prolactin	Rattus norvegicus	34-37
6320963-8	1984	We suggest that diazepam inhibits PRL secretion either by enhancing the GABAergic inhibition of PRL release, or by inhibiting, at micromolar concentrations, a benzodiazepine-sensitive Ca2+-calmodulin dependent protein kinase.	Diazepam	16-24	prolactin	Rattus norvegicus	96-99
6144438-0	1984	Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos.	Diazepam	0-8	myosin, heavy chain 15	Gallus gallus	52-58
6475562-2	1984	Pretreatment with diazepam in two doses (0.14 and 0.56 mg/kg), alpha 1,2 agonist, beta 1 agonist and beta 1 antagonist affected LD50 so that 5 to 9 per cent more contrast medium could be administered to cause the same mortality as the contrast medium alone.	Diazepam	18-26	hemoglobin, beta adult major chain	Mus musculus	82-88
6475562-2	1984	Pretreatment with diazepam in two doses (0.14 and 0.56 mg/kg), alpha 1,2 agonist, beta 1 agonist and beta 1 antagonist affected LD50 so that 5 to 9 per cent more contrast medium could be administered to cause the same mortality as the contrast medium alone.	Diazepam	18-26	hemoglobin, beta adult major chain	Mus musculus	101-107
6319679-5	1984	In addition, the effects of diazepam on norepinephrine-stimulated N-acetyltransferase (NAT) activity were studied in organ culture and dissociated cell culture.	Diazepam	28-36	N-acetyltransferase 1	Rattus norvegicus	66-85
6319679-6	1984	Diazepam (10-50 microM) both prolonged and increased the magnitude of the norepinephrine-induced increase in NAT activity but did not affect the initial rate of rise of enzyme activity.	Diazepam	0-8	N-acetyltransferase 1	Rattus norvegicus	109-112
6144438-4	1984	Diazepam can be used as a probe to study the contributory role of myosin in cellular and morphogenetic movements.	Diazepam	0-8	myosin, heavy chain 15	Gallus gallus	66-72
6144724-0	1984	The effect of neuroleptic treatment and of high dosage diazepam therapy on beta-endorphin immunoreactivity in plasma of schizophrenic patients.	Diazepam	55-63	proopiomelanocortin	Homo sapiens	75-89
6706293-1	1984	Diazepam has been reported to influence pituitary hormone secretion, with several studies claiming that diazepam provokes growth hormone release.	Diazepam	0-8	growth hormone 1	Homo sapiens	122-136
6706293-1	1984	Diazepam has been reported to influence pituitary hormone secretion, with several studies claiming that diazepam provokes growth hormone release.	Diazepam	104-112	growth hormone 1	Homo sapiens	122-136
6706293-8	1984	We conclude that diazepam inconsistently stimulates growth hormone secretion and should not be relied upon as a test of growth hormone reserve.	Diazepam	17-25	growth hormone 1	Homo sapiens	52-66
6144724-1	1984	In 14 schizophrenic patients, treated with neuroleptic drugs, and in 7 patients, treated with high-dosage diazepam, beta-endorphin-like immunoreactivity in plasma has been measured by use of a highly sensitive and relatively specific radioimmunoassay.	Diazepam	106-114	proopiomelanocortin	Homo sapiens	116-130
6663657-6	1983	In the rat, on the contrary, the serum GPT level slightly elevated due to the ethanol administration, and remained at the elevated level with the diazepam treatment in contrast with the complete recovery with non-treatment for 5 weeks after the ethanol administration.	Diazepam	146-154	glutamic--pyruvic transaminase	Rattus norvegicus	39-42
6140966-2	1983	The enhanced binding to GABAA and GABAB receptor sites and the decreased binding to benzodiazepine receptors was observed 24 hours after discontinuation of chronic treatment with diazepam (5 mg/kg, twice daily).	Diazepam	179-187	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	24-29
6322042-5	1983	A putative ligand for this site (DBI = diazepam binding inhibitor) has been isolated and purified to homogeneity.	Diazepam	39-47	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	33-36
6322044-3	1983	Diazepam reduced the rise in secretion of prolactin during proestrus and the increase in release induced by stress, administration of fluoxetine plus 5-hydroxytryptophan and haloperidol.	Diazepam	0-8	prolactin	Rattus norvegicus	42-51
6322044-9	1983	In cultures of anterior pituitary cells diazepam enhanced the inhibition of prolactin secretion produced by gamma-aminobutyric acid (GABA) and dopamine.	Diazepam	40-48	prolactin	Rattus norvegicus	76-85
6427833-0	1984	High dose diazepam treatment and its effect on prolactin secretion in adolescent schizophrenic patients.	Diazepam	10-18	prolactin	Homo sapiens	47-56
6427833-7	1984	The mild hyperprolactinemia achieved with the extremely high doses of diazepam (greater than 250 mg/day) is possibly due to activation of the GABA system which stimulates prolactin release directly or by inhibiting the dopaminergic neurons or alternatively to activation of the endorphinergic system.	Diazepam	70-78	prolactin	Homo sapiens	14-23
6640316-5	1983	Methyl-beta-carboline-3-carboxylate seems to have effects on the firing of CA1 neurons which are similar to the effects reported for ethyl-beta-carboline-3-carboxylate and opposite to those reported for the benzodiazepines midazolam and diazepam.	Diazepam	237-245	carbonic anhydrase 1	Rattus norvegicus	75-78
6663657-8	1983	In spite of the recovery, the elevation of the serum GPT level being remained by diazepam may indicate possible influence of diazepam on the liver function when the drug is administered after prolonged administration of ethanol.	Diazepam	81-89	glutamic--pyruvic transaminase	Rattus norvegicus	53-56
6663657-8	1983	In spite of the recovery, the elevation of the serum GPT level being remained by diazepam may indicate possible influence of diazepam on the liver function when the drug is administered after prolonged administration of ethanol.	Diazepam	125-133	glutamic--pyruvic transaminase	Rattus norvegicus	53-56
6304714-10	1983	DBI injected intraventricularly at doses of 5-10 nmol completely reversed the anticonflict action of diazepam on unpunished drinking and, similar to the anxiety-inducing beta-carboline derivative FG 7142 (beta-carboline-3-carboxylic acid methyl ester), facilitated the shock-induced suppression of drinking by lowering the threshold for this response.	Diazepam	101-109	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-3
6138271-1	1983	Low intravenous doses of two benzodiazepines, lorazepam and diazepam, antagonized the activation of dorsal hippocampus CA1 pyramidal neurons by kainate to a greater extent than the activations produced by glutamate and acetylcholine.	Diazepam	60-68	carbonic anhydrase 1	Rattus norvegicus	119-122
6652347-8	1983	In contrast, however, treatment with the GABA transaminase inhibitors, amino-oxyacetic acid (25 mg kg-1) or ethanolamine-O-sulphate (250 mg kg-1, 7 days) which elevated cerebral GABA concentrations, enhanced the reduction in cortical 5-HT turnover following diazepam.	Diazepam	258-266	4-aminobutyrate aminotransferase	Rattus norvegicus	41-58
6841564-0	1983	Effect of the benzodiazepine derivative, diazepam, on the clonidine-stimulated human growth hormone secretion.	Diazepam	41-49	growth hormone 1	Homo sapiens	85-99
6670224-0	1983	[Effect of phenazepam and seduxen on the presence of histidase and urokinase in the blood].	Diazepam	26-33	histidine ammonia lyase	Rattus norvegicus	53-62
6138010-0	1983	Long-term benzodiazepine administration blunts growth hormone response to diazepam.	Diazepam	74-82	growth hormone 1	Homo sapiens	47-61
6138010-5	1983	The results clearly demonstrate tolerance to the growth hormone-releasing effect of diazepam, but do not suggest receptor supersensitivity after withdrawal of benzodiazepine therapy.	Diazepam	84-92	growth hormone 1	Homo sapiens	49-63
6316193-4	1983	The peptide CCK-5-8 had weak anticonvulsant activity in comparison to the octapeptides, 3.2 mumol/kg and larger doses of the reference drug, diazepam, totally prevented picrotoxin-induced seizures and mortality.	Diazepam	141-149	cholecystokinin	Mus musculus	12-15
6836607-2	1983	Furthermore, female rats exposed prenatally to diazepam showed an increase in the TSH response to synthetic thyrotropin-releasing hormone (TRH) when tested at 10-12 weeks of age, though their serum thyroxine level was normal.	Diazepam	47-55	thyrotropin releasing hormone	Rattus norvegicus	108-137
6613337-0	1983	[Effect of seduksen (diazepam) on cortical P300 potentials evoked by neutral and emotional words].	Diazepam	11-19	E1A binding protein p300	Homo sapiens	43-47
6613337-0	1983	[Effect of seduksen (diazepam) on cortical P300 potentials evoked by neutral and emotional words].	Diazepam	21-29	E1A binding protein p300	Homo sapiens	43-47
6613337-1	1983	The influence of seduxen (diazepam) on cortical potentials P300 evoked by neutral and emotional words was studied in adult subjects having life conflicts.	Diazepam	17-24	E1A binding protein p300	Homo sapiens	59-63
6613337-1	1983	The influence of seduxen (diazepam) on cortical potentials P300 evoked by neutral and emotional words was studied in adult subjects having life conflicts.	Diazepam	26-34	E1A binding protein p300	Homo sapiens	59-63
6302432-1	1983	Treatment of rat cerebellar membranes with phospholipase A2 (PLA2) or phospholipase C (PLC) increased basal [3H]diazepam binding at 0 degrees C with concomitant disappearance of the stimulatory effect of Cl- ion on the binding.	Diazepam	112-120	phospholipase A2 group IB	Rattus norvegicus	43-59
6302432-1	1983	Treatment of rat cerebellar membranes with phospholipase A2 (PLA2) or phospholipase C (PLC) increased basal [3H]diazepam binding at 0 degrees C with concomitant disappearance of the stimulatory effect of Cl- ion on the binding.	Diazepam	112-120	phospholipase A2 group IB	Rattus norvegicus	61-65
6836607-2	1983	Furthermore, female rats exposed prenatally to diazepam showed an increase in the TSH response to synthetic thyrotropin-releasing hormone (TRH) when tested at 10-12 weeks of age, though their serum thyroxine level was normal.	Diazepam	47-55	thyrotropin releasing hormone	Rattus norvegicus	139-142
6341501-8	1983	Results suggest that (1) diazepam inhibits elevation of neural folds through its disruptive effects on the organization and contractility of apical microfilament bundles in developing neuroepithelial cells and (2) myosin may be directly involved in elevation of neural folds.	Diazepam	25-33	myosin, heavy chain 15	Gallus gallus	214-220
6847607-0	1983	Relations between high-affinity binding sites for L-tryptophan, diazepam, salicylate and Phenol Red on human serum albumin.	Diazepam	64-72	albumin	Homo sapiens	109-122
6131706-1	1983	Quantitative histochemistry was used to study the effects of phenazepam, medazepam, diazepam, and nitrazepam on GABA-transaminase activity in different rat brain structures.	Diazepam	84-92	4-aminobutyrate aminotransferase	Rattus norvegicus	112-129
6131706-2	1983	Phenazepam and diazepam, which produced anxiolytic effect in low doses, selectively inhibited GABA-transaminase of the hippocamp.	Diazepam	15-23	4-aminobutyrate aminotransferase	Rattus norvegicus	94-111
6873136-6	1983	The binding of diazepam to human serum albumin (HSA) was markedly perturbed by the presence of NEFA but not by bilirubin and there was no apparent cooperativity between bilirubin and NEFA on diazepam-HSA binding.	Diazepam	15-23	albumin	Homo sapiens	33-46
6961924-0	1982	Effect of diazepam (Valium) on LCAT activity in plasma from man.	Diazepam	10-18	lecithin-cholesterol acyltransferase	Homo sapiens	31-35
6961924-0	1982	Effect of diazepam (Valium) on LCAT activity in plasma from man.	Diazepam	20-26	lecithin-cholesterol acyltransferase	Homo sapiens	31-35
7043087-3	1982	In semi quantitative determinations, the EMIT Tox test was applied to 139 sera with one or more of the three benzodiazepines (oxazepam, desmethyldiazepam, diazepam), showing a significant correlation with levels measured by gas chromatography; but the EMIT Tox test frequently yields values too low for elevated oxazepam and desmethyldiazepam concentrations.	Diazepam	145-153	thymocyte selection associated high mobility group box	Homo sapiens	46-49
6293608-4	1982	The influence of diazepam (1 X 10(-6) M) on the population spikes (PS) evoked in the CA1 area by Schaffer"s collaterals stimulation manifested itself in a reversible decrease.	Diazepam	17-25	carbonic anhydrase 1	Homo sapiens	85-88
6286320-0	1982	Ethyl beta-carboline-3-carboxylate reverses the diazepam effect on cerebellar cyclic GMP.	Diazepam	48-56	5'-nucleotidase, cytosolic II	Mus musculus	85-88
7126855-1	1982	Influence of diazepam on the amplitude of the population spikes (PS) evoked in CA1 area by Schaffer collateral stimulation in hippocampal slices was analyzed.	Diazepam	13-21	carbonic anhydrase 1	Homo sapiens	79-82
7108150-0	1982	The response of growth hormone and prolactin to oral diazepam in diabetics.	Diazepam	53-61	growth hormone 1	Homo sapiens	16-30
6979001-3	1982	The benzodiazepine diazepam blocked stress-induced prolactin release and, when given during the critical period of proestrus, the proestrus surge of prolactin.	Diazepam	19-27	prolactin	Rattus norvegicus	51-60
6979001-3	1982	The benzodiazepine diazepam blocked stress-induced prolactin release and, when given during the critical period of proestrus, the proestrus surge of prolactin.	Diazepam	19-27	prolactin	Rattus norvegicus	149-158
6979001-4	1982	Diazepam administration also blunted the release of prolactin induced by dopaminergic receptor blockade following haloperidol, or by serotonergic receptor activation produced by fluoxetine, a serotonergic reuptake inhibitor plus 5-hydroxytryptophan, a serotonin precursor.	Diazepam	0-8	prolactin	Rattus norvegicus	52-61
6979001-5	1982	Inhibition of prolactin release by benzodiazepine was dose related, and inhibition was still evident after repeated diazepam injection.	Diazepam	116-124	prolactin	Rattus norvegicus	14-23
6979001-6	1982	The potency of three benzodiazepine analogues to inhibit prolactin release correlated with their potency to displace radiolabeled diazepam binding from brain membrane fractions or to induce other biological responses (clonazepam greater than diazepam greater than chlordiazepoxide).	Diazepam	130-138	prolactin	Rattus norvegicus	57-66
6979001-6	1982	The potency of three benzodiazepine analogues to inhibit prolactin release correlated with their potency to displace radiolabeled diazepam binding from brain membrane fractions or to induce other biological responses (clonazepam greater than diazepam greater than chlordiazepoxide).	Diazepam	242-250	prolactin	Rattus norvegicus	57-66
6270544-6	1981	Of particular interest are the effects of GABA agonists on the binding of diazepam to the benzodiazepine binding site, assumed to be a structural unit of the GABA receptor complex.	Diazepam	74-82	GABA type A receptor-associated protein	Homo sapiens	158-171
7178369-0	1982	Inhibitory effect of phentolamine on diazepam-induced growth hormone secretion and lack of effect of diazepam on prolactin secretion in man.	Diazepam	37-45	growth hormone 1	Homo sapiens	54-68
7178369-1	1982	Phentolamine, a postsynaptic noradrenergic (NA) receptor blocker, inhibits diazepam-induced growth hormone (GH) secretion in man.	Diazepam	75-83	growth hormone 1	Homo sapiens	92-106
7178369-6	1982	Prolactin secretion after administration of diazepam (10 mg i.v.)	Diazepam	44-52	prolactin	Homo sapiens	0-9
7178370-0	1982	Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man.	Diazepam	67-75	growth hormone 1	Homo sapiens	14-28
6120127-1	1981	In gross-behavioral observations, chlordiazepoxide, diazepam, meprobamate, and pentobarbital-Na produced excitatory behavior at 5 and 10, 1 and 2, 100 and 200, and 10 and 20 mg/kg p.o., respectively whereas afloqualone produced no excitatory behavior at doses up to 20 mg/kg p.o., these doses induce muscle relaxation and motor depression.	Diazepam	52-60	angiotensin II receptor, type 1a	Rattus norvegicus	125-145
7337498-15	1981	Both diazepam and desmethyldiazepam rapidly passed the blood/CSF barrier and reached steady state concentrations is CSF corresponding to the part not bound to serum proteins.	Diazepam	5-13	colony stimulating factor 2	Canis lupus familiaris	61-64
7337498-15	1981	Both diazepam and desmethyldiazepam rapidly passed the blood/CSF barrier and reached steady state concentrations is CSF corresponding to the part not bound to serum proteins.	Diazepam	5-13	colony stimulating factor 2	Canis lupus familiaris	116-119
7237786-7	1981	Binding by the patient"s plasma of diazepam (1020 mg/L) and warfarin (1040 mg/L), which bind primarily to albumin, as well as of propranolol (1.05 g/L), which binds primarily to alpha 1-acid glycoprotein, was also studied.	Diazepam	35-43	albumin	Homo sapiens	106-113
7402439-0	1980	Diazepam effects on striatal met-enkephalin levels following long-term pharmacological manipulations.	Diazepam	0-8	proopiomelanocortin	Homo sapiens	29-43
6267610-1	1981	We found that two markers of differentiation, tyrosinase (monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1) activity and melanin synthesis, are induced by diazepam in B16/C3 mouse melanoma cells.	Diazepam	177-185	tyrosinase	Mus musculus	46-56
7269901-2	1981	These substances, acting as inductors of microsomal oxidases with mixed function (cytochrome P-450 and P-448), are phenobarbital, 3-methylcholanthrene, DDT, diphenin, rifampicin, benzodiazepin derivatives (diazepam and phenazepam).	Diazepam	206-214	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	82-108
7024080-0	1981	Diazepam test of growth hormone secretion.	Diazepam	0-8	growth hormone 1	Homo sapiens	17-31
6779635-1	1981	Diazepam in a dose of 0.75, 1.25, or 2.5 mg was force-fed to mice during 3 days of oocyte maturation and superovulation induced with pregnant mare"s serum and human chorionic gonadotropin (hCG).	Diazepam	0-8	chorionic gonadotropin subunit beta 5	Homo sapiens	189-192
6115607-3	1981	The levels of diazepam in the CSF were low compared with the plasms concentrations and around the same level as the free circulating fraction.	Diazepam	14-22	colony stimulating factor 2	Homo sapiens	30-33
6258938-0	1980	Ethyl beta-carboline-3-carboxylate antagonises the effect of diazepam on a functional GABA receptor.	Diazepam	61-69	GABA type A receptor-associated protein	Homo sapiens	86-99
522892-0	1979	Rapid changes in enkephalin levels in rat striatum and hypothalamus induced by diazepam.	Diazepam	79-87	proenkephalin	Rattus norvegicus	17-27
6769453-7	1980	4 CSF diazepam was in equilibrium with unbound plasma diazepam and salivary diazepam.	Diazepam	6-14	colony stimulating factor 2	Homo sapiens	2-5
7203397-1	1980	The effect of hyperglycemia on growth hormone, thyroid-stimulating hormone, and prolactin response to oral diazepam (10 mg) was assessed in 7 normal subjects.	Diazepam	107-115	prolactin	Homo sapiens	80-89
7203397-2	1980	A peak growth hormone response of 13.5 +/- 0.3 ng/ml (mean +/- SEM) significantly above the base line (p less than 0.001) was achieved when diazepam was given alone.	Diazepam	140-148	growth hormone 1	Homo sapiens	7-21
393269-0	1979	Intravascular factors affecting diazepam binding to human serum albumin.	Diazepam	32-40	albumin	Homo sapiens	58-71
387427-0	1979	Diazepam induces relaxation of chick embryo muscle fibers in vitro and inhibits myosin synthesis.	Diazepam	0-8	myosin, heavy chain 15	Gallus gallus	80-86
522892-2	1979	Diazepam selectively increased the enkephalin concentrations in the hypothalamus by about 35%, and lowered it in the corpus striatum by roughly 25%; no changes could be detected in the medulla oblongata/pons or midbrain.	Diazepam	0-8	proenkephalin	Rattus norvegicus	35-45
522892-1	1979	The acute treatment of rats with diazepam induces pronounced changes in brain enkephalin concentrations, as was estimated for methionine(met)-enkephalin and in some representative experiments for leucine(leu)-enkephalin, employing highly specific radioimmunoassays.	Diazepam	33-41	proenkephalin	Rattus norvegicus	78-88
522892-1	1979	The acute treatment of rats with diazepam induces pronounced changes in brain enkephalin concentrations, as was estimated for methionine(met)-enkephalin and in some representative experiments for leucine(leu)-enkephalin, employing highly specific radioimmunoassays.	Diazepam	33-41	proenkephalin	Rattus norvegicus	142-152
522892-1	1979	The acute treatment of rats with diazepam induces pronounced changes in brain enkephalin concentrations, as was estimated for methionine(met)-enkephalin and in some representative experiments for leucine(leu)-enkephalin, employing highly specific radioimmunoassays.	Diazepam	33-41	proenkephalin	Rattus norvegicus	142-152
38696-1	1979	Oxygen consumption (VO2) was measured in ten patients before and after the administration of 0.28 mg.kg-1 of diazepam, using a spirometer placed in the circuit of an MA1 respirator functioning on a closed circuit basis.	Diazepam	109-117	PNMA family member 1	Homo sapiens	166-169
420938-1	1979	The effect of diazepam and nitrazepam (0.5, 1, 2.5, and 5 mg/kg) on GABA-transaminase activity in the rat cerebellar cortex and hippocampus was investigated by quantitative histochemistry.	Diazepam	14-22	4-aminobutyrate aminotransferase	Rattus norvegicus	68-85
295284-0	1979	The biphasic effect of gradually increased doses of diazepam on prolactin secretion in acute schizophrenic patients.	Diazepam	52-60	prolactin	Homo sapiens	64-73
445950-2	1979	The initial rapid exponential decline of plasma diazepam concentrations (t1/2 alpha) was more rapid during (0.21 +/- 0.03 hr) than after withdrawal (0.44 +/- 0.14 hr, p less than 0.05).	Diazepam	48-56	interleukin 1 receptor like 1	Homo sapiens	73-83
571707-0	1979	[Determination of the binding of chlorodiazepoxide, diazepam, nitrazepam and phenprocoumon to human and bovine serum albumin (author"s transl)].	Diazepam	52-60	albumin	Homo sapiens	111-124
437076-0	1979	[Effect of droperidol, aminazine and diazepam on the analgesic activity of leucine-enkephalin].	Diazepam	37-45	proenkephalin	Rattus norvegicus	83-93
370137-0	1979	The effect of methysergide, pimozide, and sodium valproate on the diazepam-stimulated growth hormone secretion in man.	Diazepam	66-74	growth hormone 1	Homo sapiens	86-100
649236-2	1978	Diazepam elimination half-life (t1/2beta) and weight-corrected volume of distribution (Vd) were significantly larger in patients with cirrhosis (n = 9) than in controls (n = 4).	Diazepam	0-8	interleukin 1 receptor like 1	Homo sapiens	32-40
30521-0	1978	Benzodiasepine and neurotransmitter receptor binding in rat brain after chronic administration of diazepam or phenobarbital.	Diazepam	98-106	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	19-44
356519-0	1978	[Effect of diazepam (Seduxen) on true cholinesterase activity].	Diazepam	11-19	butyrylcholinesterase	Homo sapiens	38-52
356519-0	1978	[Effect of diazepam (Seduxen) on true cholinesterase activity].	Diazepam	21-28	butyrylcholinesterase	Homo sapiens	38-52
565534-3	1978	Lower concentrations of diazepam allow cell fusion to occur, but inhibit the synthesis and accumulation of myosin heavy chain, implying that cell fusion does not obligate myoblasts to synthesize and accumulate large quantities of muscle specific protein.	Diazepam	24-32	myosin, heavy chain 15	Gallus gallus	107-125
29327-2	1978	Flurazepam, temazepam, lorazepam, flunitrazepam and diazepam had an inhibitory effect on plasma cholinesterase of 60--90 per cent and, with the exception of lorazepam, an inhibitory effect of 40--50 per cent on red cell cholinesterase.	Diazepam	52-60	butyrylcholinesterase	Homo sapiens	96-110
29327-2	1978	Flurazepam, temazepam, lorazepam, flunitrazepam and diazepam had an inhibitory effect on plasma cholinesterase of 60--90 per cent and, with the exception of lorazepam, an inhibitory effect of 40--50 per cent on red cell cholinesterase.	Diazepam	52-60	butyrylcholinesterase	Homo sapiens	220-234
357700-0	1978	[Binding of prazepam, desalkylprazepam and diazepam to human serum albumin (author"s transl)].	Diazepam	43-51	albumin	Homo sapiens	61-74
670897-3	1978	The prothrombin time was considerably shortened when the application of Diazepam or Nitrazepam was stopped although Phenprocoumon was still applied.	Diazepam	72-80	coagulation factor II	Rattus norvegicus	4-15
334786-2	1977	A rapid method was developed for the determination of diazepam and nordiazepam (N-desmethyldiazepam) in human plasma using electron capture gas--liquid chromatography (GLC--ECE).	Diazepam	54-62	endothelin converting enzyme 1	Homo sapiens	173-176
588298-0	1977	Circular dichroism studies on the inhibiting effect of oleic acid on the binding of diazepam to human serum albumin.	Diazepam	84-92	albumin	Homo sapiens	102-115
901814-5	1977	The fragment mainly retains the secondary and tertiary structure of intact human serum albumin as well as its capacity to bind bilirubin and diazepam.	Diazepam	141-149	albumin	Homo sapiens	87-94
889746-1	1977	A 10 mg dose of diazepam was given intravenously to mothers at 15 to 205 minutes before delivery, and plasma diazepam concentrations were measured by gas-liquid chromatography in mothers and infants at delivery and again 24 hours later.	Diazepam	16-24	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	0-4
916171-0	1977	[The effect of diazepam-ketamine-nitrous oxide anesthesia and surgery on plasma levels of thyroid hormones, growth hormone, and insulin in man (author"s transl)].	Diazepam	15-23	growth hormone 1	Homo sapiens	108-122
916171-0	1977	[The effect of diazepam-ketamine-nitrous oxide anesthesia and surgery on plasma levels of thyroid hormones, growth hormone, and insulin in man (author"s transl)].	Diazepam	15-23	insulin	Homo sapiens	128-135
863908-5	1977	The binding properties of the HSA derivatives have been tested with bilirubin, diazepam (a benzodiazepine drug), phenylbutazone, and indomethacin by circular dichroism.	Diazepam	79-87	albumin	Homo sapiens	30-33
863908-6	1977	The binding of diazepam to DHCH-HSA is almost completely inhibited and that of phenylbutazone and indomethacin decreased, while the binding of bilirubin is essentially unaffected.	Diazepam	15-23	albumin	Homo sapiens	32-35
1180618-4	1975	Although diazepam alone had no inducing effect, its use with ethanol increased the cytochrome P-450 content (56%) and the rate of metabolism of N-methylaniline (44%) more than ethanol alone.	Diazepam	9-17	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	83-99
840320-11	1977	Diazepam, sodium valproate, ethosuximide and trimethadione antagonized the inhibition of GAD and the decrease in GABA concentrations caused by isoniazid.	Diazepam	0-8	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	89-92
991920-1	1976	Two clinically effective anticonvulsants, phenobarbitone and diazepam, protected 5-day old chicks against picrotoxin convulsions without reducing brain GABA-transaminase activity or raising brain GABA concentration.	Diazepam	61-69	4-aminobutyrate aminotransferase	Homo sapiens	152-169
187962-7	1976	Enhancement of GABAergic transmission by diazepam or aminooxyacetic acid antagonized the rise in cerebellar cyclic GMP content induced by the dopaminergic stimulants, but was without effect on the cyclic GMP content in the medial forebrain.	Diazepam	41-49	5'-nucleotidase, cytosolic II	Mus musculus	115-118
964287-4	1976	The plasma clearance of diazepam could be correlated neither with a quantitative measure of liver function, as estimated by galactose elimination capacity, nor to semiquantitative measures of liver function, such as serum albumin and prothrombin.	Diazepam	24-32	coagulation factor II, thrombin	Homo sapiens	234-245
181685-3	1976	Pretreatment with diazepam completely abolished the effect of picrotoxin and harmaline and significantly reduced the effects of pentetrazol and oxotremorine on cyclic GMP levels, but the tremor due to harmaline and oxotremorine was not blocked.	Diazepam	18-26	5'-nucleotidase, cytosolic II	Mus musculus	167-170
181685-6	1976	Since pentobarbital and diazepam also decreased cyclic GMP levels in a dose-dependent manner in brains of control animals, the changes in cyclic GMP levels observed after administration of excitatory drugs appear to be related to the arousal reaction of the central nervous system.	Diazepam	24-32	5'-nucleotidase, cytosolic II	Mus musculus	55-58
181685-6	1976	Since pentobarbital and diazepam also decreased cyclic GMP levels in a dose-dependent manner in brains of control animals, the changes in cyclic GMP levels observed after administration of excitatory drugs appear to be related to the arousal reaction of the central nervous system.	Diazepam	24-32	5'-nucleotidase, cytosolic II	Mus musculus	145-148
1100541-3	1975	There was a dose-dependent rise in GH after diazepam administration, and the rise was related to the peak plasma level of the drug.	Diazepam	44-52	growth hormone 1	Homo sapiens	35-37
1148025-0	1975	The displacing effect of a fatty acid on the binding of diazepam to human serum albumin.	Diazepam	56-64	albumin	Homo sapiens	74-87
1100541-4	1975	A highly significant correlation between the concentrations of serum GH and plasma diazepam was found.	Diazepam	83-91	growth hormone 1	Homo sapiens	69-71
1100541-6	1975	and oral administration of 10 mg of diazepam, the peak GH levels, reached in 30 and 60 minutes (19.6+/-2.9 and 15.2+/-3.2ng/ml, respectively), were significantly higher than those during saline and placebo periods (4.3+/-0.8 and 5.9+/-1.1 ng/ml, respectively).	Diazepam	36-44	growth hormone 1	Homo sapiens	55-57
805836-6	1975	In addition, TRH reduced the sleep and hypothermia produced by thiopental, amobarbital, secobarbital and phenobarbital, and it antagonized the hypothermia and reduced motor activity produced by chloral hydrate, reserpine, chlorpromazine and diazepam.	Diazepam	241-249	thyrotropin releasing hormone	Homo sapiens	13-16
1125412-4	1975	Using this test an antagonistic relationship was observed between diazepam on the one hand, and biculline and thiosemicarbazide--on the other Diazepam was capable of increasing GABA content in the brain by suppressing GABA-transaminase activity in the mitochondrial fraction of the brain tissue.	Diazepam	142-150	4-aminobutyrate aminotransferase	Homo sapiens	218-235
5717291-0	1968	Diazepam as an aid in the photo-Metrazol activation test.	Diazepam	0-8	activation induced cytidine deaminase	Homo sapiens	15-18
1127104-3	1975	In the normal individuals, the terminal plasma half-life of diazepam, (t 1/2 (B)) exhibited a striking age-dependence; at 20 yr the t 1/2 (beta) was about 20 h, but it increased linearly with age to about 90 h at 80 yr.	Diazepam	60-68	interleukin 1 receptor like 1	Homo sapiens	71-74
1127104-3	1975	In the normal individuals, the terminal plasma half-life of diazepam, (t 1/2 (B)) exhibited a striking age-dependence; at 20 yr the t 1/2 (beta) was about 20 h, but it increased linearly with age to about 90 h at 80 yr.	Diazepam	60-68	interleukin 1 receptor like 1	Homo sapiens	132-144
1127104-9	1975	It appears then that the prolongation of t 1/2 (beta) of diazepam with age is primarily dependent on an increase in the initial distribution volume of the drug.	Diazepam	57-65	interleukin 1 receptor like 1	Homo sapiens	41-53
242202-1	1975	With the use of quantitative microspectrofluorometry, it has been shown that diazepam (10 mg/kg) and chlordiazepoxide (10 mg/kg) reduce DA turnover in the tuberculum olfactorium, nuc.	Diazepam	77-85	nucleobindin 1	Homo sapiens	179-182
242202-4	1975	It is of considerable interest that with a dose of 1 mg/kg of diazepam a reduction of DA turnover can still be observed in the tuberculum olfactorium and nuc.	Diazepam	62-70	nucleobindin 1	Homo sapiens	154-157
4428773-0	1974	[The effect of diazepam, pentazocine, and xylocaine on the serum levels of CPK, GOT and LDH (author"s transl)].	Diazepam	15-23	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	75-78
4479747-0	1974	Effect of diazepin derivatives on cholinesterase activity.	Diazepam	10-18	butyrylcholinesterase	Homo sapiens	34-48
33950681-8	2021	MD simulation and MM-PBSA calculation results demonstrated that there is likely a synergetic effect between OXY and DZP binding to opioid receptors, as OXY is likely to target the active MOR while DZP selectively binds to the active KOR.	Diazepam	116-119	opioid receptor mu 1	Homo sapiens	187-190
33950681-8	2021	MD simulation and MM-PBSA calculation results demonstrated that there is likely a synergetic effect between OXY and DZP binding to opioid receptors, as OXY is likely to target the active MOR while DZP selectively binds to the active KOR.	Diazepam	116-119	opioid receptor kappa 1	Homo sapiens	233-236
30504824-3	2021	Combining connectome data with immediate early gene (IEG) activation maps, we identified the CEA as a primary site for diazepam (DZP) anxiolytic action.	Diazepam	119-127	CEA cell adhesion molecule 6	Homo sapiens	93-96
34014994-6	2021	Subsequently, the effects on T cell proliferation of either GABA(A)R modulation by diazepam that is also capable of activating mitochondrial based translocator protein (TSPO), alprazolam and allopregnanolone or inhibition by bicucculine methiodide (BMI) and (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) were assessed.	Diazepam	83-91	translocator protein	Homo sapiens	169-173
34004209-8	2021	We further found that the decrease in head-dipping behavior caused by diazepam was blocked by bumetanide, a Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) antagonist, in LPS-treated mice.	Diazepam	70-78	solute carrier family 12, member 2	Mus musculus	108-143
34004209-8	2021	We further found that the decrease in head-dipping behavior caused by diazepam was blocked by bumetanide, a Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) antagonist, in LPS-treated mice.	Diazepam	70-78	solute carrier family 12, member 2	Mus musculus	145-150
33921765-2	2021	In fact, TSPO was initially described as a peripheral benzodiazepine receptor (PBR) with a secondary binding site for diazepam.	Diazepam	118-126	translocator protein	Homo sapiens	9-13
33921765-2	2021	In fact, TSPO was initially described as a peripheral benzodiazepine receptor (PBR) with a secondary binding site for diazepam.	Diazepam	118-126	translocator protein	Homo sapiens	43-77
33921765-2	2021	In fact, TSPO was initially described as a peripheral benzodiazepine receptor (PBR) with a secondary binding site for diazepam.	Diazepam	118-126	translocator protein	Homo sapiens	79-82
34004209-9	2021	These findings suggest that diazepam induces the anxiety-like behavior under inflammation conditions, and may cause the GABAA receptor dysfunction associated with the chloride plasticity mediated by NKCC1, which contributes to benzodiazepine-induced delirium after surgery.	Diazepam	28-36	solute carrier family 12, member 2	Mus musculus	199-204
33947925-4	2021	We found Ts65Dn mice to be less sensitive to diazepam, as assessed by electroencephalography, long-term potentiation, and elevated plus-maze.	Diazepam	45-53	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	9-15
33947925-5	2021	Still, diazepam pre-treatment displayed typical effectiveness in reducing susceptibility and severity to picrotoxin-induced seizures in Ts65Dn mice.	Diazepam	7-15	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	136-142
33622083-0	2021	Using the CYP3A Activity Evaluation to Predict the Efficacy and Safety of Diazepam in Patients With Alcohol Withdrawal Syndrome.	Diazepam	74-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	10-15
33622083-3	2021	OBJECTIVE: The objective of our study was to study the effect of CYP3A isoenzymes activity on the efficacy and safety of diazepam in patients with AWS.	Diazepam	121-129	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-70
33622083-8	2021	CONCLUSION: Possible relationship between the CYP3A activity, evaluated by the content of the urinary endogenous substrate of the given isoenzyme and its metabolite, the 6-beta-hydroxy cortisol (6-beta-HC) / cortisol ratio, and the efficacy of diazepam was demonstrated.	Diazepam	244-252	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	46-51
30504824-3	2021	Combining connectome data with immediate early gene (IEG) activation maps, we identified the CEA as a primary site for diazepam (DZP) anxiolytic action.	Diazepam	129-132	CEA cell adhesion molecule 6	Homo sapiens	93-96
30504824-4	2021	Deep brain calcium imaging revealed that brain-wide DZP interactions shifted neuronal activity in CEA microcircuits.	Diazepam	52-55	CEA cell adhesion molecule 6	Homo sapiens	98-101
30504824-5	2021	Chemogenetic silencing showed that PKCdelta+/SST- neurons in the lateral CEA (CEAl) are necessary and sufficient to induce the DZP anxiolytic effect.	Diazepam	127-130	protein kinase C delta	Homo sapiens	35-43
30504824-5	2021	Chemogenetic silencing showed that PKCdelta+/SST- neurons in the lateral CEA (CEAl) are necessary and sufficient to induce the DZP anxiolytic effect.	Diazepam	127-130	CEA cell adhesion molecule 6	Homo sapiens	73-76
30504824-5	2021	Chemogenetic silencing showed that PKCdelta+/SST- neurons in the lateral CEA (CEAl) are necessary and sufficient to induce the DZP anxiolytic effect.	Diazepam	127-130	CEA cell adhesion molecule 6	Homo sapiens	78-82
33424340-13	2021	The level of C-reactive protein (CRP) and cholesterol was increased significantly (p < 0.01; p < 0.001) by stress while restored significantly (p < 0.01; p < 0.001) by diazepam.	Diazepam	168-176	C-reactive protein	Rattus norvegicus	13-31
33396073-2	2021	In this study, female and male zebrafish were subjected to chronic exposure (21 days) to sublethal doses (120 and 12 microg/L) of DZP, aimed to compare the characteristics of their behavioral responses to DZP exposure, and to investigate the possible links between those behavioral responses and variations in their brain gamma-aminobutyric acid (GABA) and acetylcholinesterase (AChE) levels.	Diazepam	130-133	acetylcholinesterase	Danio rerio	379-383
33396073-8	2021	Sex-dependent responses in brain GABA and AChE levels due to DZP exposure were also identified.	Diazepam	61-64	acetylcholinesterase	Danio rerio	42-46
33081988-1	2021	The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an alternative binding site for the benzodiazepine diazepam.	Diazepam	121-129	translocator protein	Homo sapiens	4-31
33081988-1	2021	The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an alternative binding site for the benzodiazepine diazepam.	Diazepam	121-129	translocator protein	Homo sapiens	33-37
33424340-13	2021	The level of C-reactive protein (CRP) and cholesterol was increased significantly (p < 0.01; p < 0.001) by stress while restored significantly (p < 0.01; p < 0.001) by diazepam.	Diazepam	168-176	C-reactive protein	Rattus norvegicus	33-36
32931814-12	2020	The MEK-ERK pathway is significantly involved in anxiolytic action of diazepam and its prolonged inhibition produces anxiolytic-like phenotype in mice.	Diazepam	70-78	midkine	Mus musculus	4-7
32157940-1	2020	We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel "hunger factor": a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity.	Diazepam	62-70	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	23-54
32157940-1	2020	We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel "hunger factor": a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity.	Diazepam	62-70	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	56-60
32157940-1	2020	We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel "hunger factor": a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity.	Diazepam	62-70	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	90-93
32931814-6	2020	We analysed the phosphorylation status of ERK1/2 and CaMKII in mice treated with a well-known anxiolytic drug - diazepam.	Diazepam	112-120	mitogen-activated protein kinase 3	Mus musculus	42-48
32931814-12	2020	The MEK-ERK pathway is significantly involved in anxiolytic action of diazepam and its prolonged inhibition produces anxiolytic-like phenotype in mice.	Diazepam	70-78	mitogen-activated protein kinase 1	Mus musculus	8-11
32931814-6	2020	We analysed the phosphorylation status of ERK1/2 and CaMKII in mice treated with a well-known anxiolytic drug - diazepam.	Diazepam	112-120	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	53-59
32931814-9	2020	Anxiolytic effects of acute diazepam are accompanied by decreased p-ERK1/2 and upregulation of p-CaMKII.	Diazepam	28-36	mitogen-activated protein kinase 3	Mus musculus	68-74
32931814-9	2020	Anxiolytic effects of acute diazepam are accompanied by decreased p-ERK1/2 and upregulation of p-CaMKII.	Diazepam	28-36	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	97-103
32931814-11	2020	Co-administration of subeffective doses of SL-327 and diazepam induces anxiolysis, which is CaMKII-independent and correlates to selectively decreased phosphoactive ERK1/2 in the hippocampus.	Diazepam	54-62	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	92-98
32931814-11	2020	Co-administration of subeffective doses of SL-327 and diazepam induces anxiolysis, which is CaMKII-independent and correlates to selectively decreased phosphoactive ERK1/2 in the hippocampus.	Diazepam	54-62	mitogen-activated protein kinase 3	Mus musculus	165-171
33255185-0	2020	Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.	Diazepam	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	41-73
33255185-8	2020	Diazepam also promotes up-regulation of CYP2B6 in PHHs and in HepaRG cells.	Diazepam	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	40-46
33255185-0	2020	Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.	Diazepam	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	75-78
33255185-9	2020	However, in humanized CAR mice, diazepam significantly induces neither CYP2B6 nor Cyp2b10 genes nor does it regulate critical genes involved in glucose and lipids metabolism and liver proliferation.	Diazepam	32-40	nuclear receptor subfamily 1, group I, member 3	Mus musculus	22-25
33255185-2	2020	Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activator not interacting with the CAR cavity.	Diazepam	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	50-53
33255185-10	2020	Thus, we demonstrate that diazepam interacts with human CAR-LBD as a weak ligand, but it does not significantly affect expression of tested CAR target genes in CAR humanized mice.	Diazepam	26-34	nuclear receptor subfamily 1 group I member 3	Homo sapiens	56-59
33255185-2	2020	Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activator not interacting with the CAR cavity.	Diazepam	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	106-109
33255185-2	2020	Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activator not interacting with the CAR cavity.	Diazepam	0-8	nuclear receptor subfamily 1 group I member 3	Homo sapiens	106-109
33255185-3	2020	In this study, we sought to determine if diazepam is a ligand directly interacting with the CAR ligand binding domain (LBD) and if it regulates its target genes in a therapeutically relevant concentration.	Diazepam	41-49	nuclear receptor subfamily 1 group I member 3	Homo sapiens	92-95
33255185-6	2020	Diazepam and its metabolites such as nordazepam, temazepam, and oxazepam are activators of CAR+Ala in translocation and two-hybrid assays and fit the CAR cavity in docking experiments.	Diazepam	0-8	nuclear receptor subfamily 1, group I, member 3	Mus musculus	91-94
32959410-6	2020	RESULTS: Use of a non-IV BZD with high estimated effectiveness, like intranasal midazolam, rather than one with low estimated effectiveness, like rectal diazepam, would result in a median (p25 -p75 ) reduction in hospital admissions from 6 (3.9-8.8) to 1.1 (0.7-1.8) per 100 cases and associated cost reductions of $638 ($289-$1064) per pediatric patient and $1107 ($972-$1281) per adult patient.	Diazepam	153-161	tubulin polymerization promoting protein	Homo sapiens	189-192
33142416-0	2020	Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors.	Diazepam	73-81	kinase insert domain receptor	Homo sapiens	114-121
32736086-8	2020	The beta1-specific antagonist, salicylidene salicylhydrazide (SCS), produced faster recovery from ethanol- and diazepam-induced ataxia, but did not alter propofol- or etomidate-induced ataxia.	Diazepam	111-119	brain protein 1	Mus musculus	4-9
28520370-0	2012	Diazepam Therapy and CYP2C19 Genotype Diazepam is a benzodiazepine with several clinical uses, including the management of anxiety, insomnia, muscle spasms, seizures, and alcohol withdrawal.	Diazepam	38-46	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	21-28
28520370-2	2012	Diazepam is primarily metabolized by CY2C19 and CYP3A4 to the major active metabolite, desmethyldiazepam.	Diazepam	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-54
33014431-7	2020	Furthermore, treatment with low-dose diazepam (a positive allosteric modulator of GABAA receptors), which enhances GABAAR function, also markedly ameliorates severity of epileptic seizures in ALG13KO mice.	Diazepam	37-45	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	115-121
33014431-7	2020	Furthermore, treatment with low-dose diazepam (a positive allosteric modulator of GABAA receptors), which enhances GABAAR function, also markedly ameliorates severity of epileptic seizures in ALG13KO mice.	Diazepam	37-45	asparagine-linked glycosylation 13	Mus musculus	192-197
32547372-5	2020	Sublenticular extended amygdalar Zif268/Egr1-expressing neuronal clusters participated in stress processing because increasing numbers of cells were observed in SLEA-zNCs after exposure to restraint stress (RS), the induction of which was suppressed by diazepam treatment.	Diazepam	253-261	early growth response 1	Mus musculus	33-39
32454511-8	2020	Further studies showed that diazepam normalized Csf1 and C3 mRNA in the PFC, and prevented increases in Csf1r and Cd11b in frontal cortex microglia following CUS.	Diazepam	28-36	colony stimulating factor 1 (macrophage)	Mus musculus	48-52
32454511-8	2020	Further studies showed that diazepam normalized Csf1 and C3 mRNA in the PFC, and prevented increases in Csf1r and Cd11b in frontal cortex microglia following CUS.	Diazepam	28-36	colony stimulating factor 1 receptor	Mus musculus	104-109
32454511-8	2020	Further studies showed that diazepam normalized Csf1 and C3 mRNA in the PFC, and prevented increases in Csf1r and Cd11b in frontal cortex microglia following CUS.	Diazepam	28-36	integrin alpha M	Mus musculus	114-119
32454511-10	2020	Confocal imaging in Thy1-GFP(M) mice demonstrated that diazepam limited microglial engulfment of neuronal elements and blocked CUS-induced dendritic spine loss in the medial PFC.	Diazepam	55-63	thymus cell antigen 1, theta	Mus musculus	20-24
32824060-10	2020	The ATR/FT-IR and XPS spectroscopy results indicated that the La(III) and Ni(II) ions were coordinated with the sulfonate groups.	Diazepam	62-69	ATR serine/threonine kinase	Homo sapiens	4-7
32359429-7	2020	Consistent with the diminished function of KCC2, adult naked mole-rats demonstrate a reduced efficacy of inhibition that manifests as triggering of seizures at room temperature by the GABAA receptor (GABAAR) positive allosteric modulator diazepam.	Diazepam	238-246	solute carrier family 12 member 5	Homo sapiens	43-47
32078882-4	2020	It was found that diazepam and temazepam were the major psychoactive substances in the tap water with the median concentration of 1.0 and 0.06 ng L-1, respectively.	Diazepam	18-26	nuclear RNA export factor 1	Homo sapiens	87-90
32078882-4	2020	It was found that diazepam and temazepam were the major psychoactive substances in the tap water with the median concentration of 1.0 and 0.06 ng L-1, respectively.	Diazepam	18-26	immunoglobulin kappa variable 1-16	Homo sapiens	146-149
32569808-14	2020	In conclusion, c-tDCS alone or in combination with a low dose of DZP showed to affect neuroinflammation, improving central neurotrophin levels and decreasing hippocampal IL-1beta levels after PTZ-induced kindling without statistically significant effect on seizure behavior.	Diazepam	65-68	interleukin 1 alpha	Rattus norvegicus	170-178
32870779-6	2020	Lastly, we show the positive allosteric modulator diazepam enhanced GABA-A currents on dopaminergic axons and directly inhibited release, but also likely acts by reducing excitation from cholinergic interneurons.	Diazepam	50-58	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	68-74
32547372-5	2020	Sublenticular extended amygdalar Zif268/Egr1-expressing neuronal clusters participated in stress processing because increasing numbers of cells were observed in SLEA-zNCs after exposure to restraint stress (RS), the induction of which was suppressed by diazepam treatment.	Diazepam	253-261	early growth response 1	Mus musculus	40-44
32102779-7	2020	In parallel, nicotine-related alterations in GABA signaling observed ex vivo were associated with enhanced diazepam-induced inhibition of lateral VTA DA neurons in vivo Targeting KCC2 with the agonist CLP290 normalized diazepam-induced effects on VTA GABA transmission and reduced diazepam consumption following nicotine administration to the control level.	Diazepam	107-115	solute carrier family 12 member 5	Rattus norvegicus	179-183
32455588-6	2020	The two peptides displayed some strong differences compared with diazepam in terms of c-Fos expression modulation in the prefontal cortex, the amygdala, the nucleus of the tractus solitarius, the periaqueductal grey, and the raphe magnus nucleus, implying a potentially different mode of action.	Diazepam	65-73	FBJ osteosarcoma oncogene	Mus musculus	86-91
31283949-2	2020	This has led to the identification of an 86-amino acid polypeptide capable of displacing [3H]diazepam binding to brain membranes, thus called diazepam-binding inhibitor (DBI).	Diazepam	93-101	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	142-168
31283949-2	2020	This has led to the identification of an 86-amino acid polypeptide capable of displacing [3H]diazepam binding to brain membranes, thus called diazepam-binding inhibitor (DBI).	Diazepam	93-101	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	170-173
31802434-0	2020	HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window.	Diazepam	47-55	high mobility group box 1	Homo sapiens	0-5
31802434-2	2020	Here, we investigated the proinflammatory cytokine high mobility group box-1 (HMGB1) as a candidate therapeutic target for diazepam (DZP)-refractory SE.	Diazepam	123-131	high mobility group box 1	Homo sapiens	51-76
31802434-2	2020	Here, we investigated the proinflammatory cytokine high mobility group box-1 (HMGB1) as a candidate therapeutic target for diazepam (DZP)-refractory SE.	Diazepam	123-131	high mobility group box 1	Homo sapiens	78-83
31802434-2	2020	Here, we investigated the proinflammatory cytokine high mobility group box-1 (HMGB1) as a candidate therapeutic target for diazepam (DZP)-refractory SE.	Diazepam	133-136	high mobility group box 1	Homo sapiens	51-76
31802434-2	2020	Here, we investigated the proinflammatory cytokine high mobility group box-1 (HMGB1) as a candidate therapeutic target for diazepam (DZP)-refractory SE.	Diazepam	133-136	high mobility group box 1	Homo sapiens	78-83
31802434-4	2020	Exogenous HMGB1 was sufficient to directly induce DZP-refractory SE in nonrefractory SE.	Diazepam	50-53	high mobility group box 1	Homo sapiens	10-15
31802434-5	2020	Neutralization of HMGB1 with an anti-HMGB1 monoclonal antibody decreased the incidence of SE and alleviated the severity of seizure activity in DZP-refractory SE, which was mediated by a Toll-like receptor 4 (TLR4)-dependent pathway.	Diazepam	144-147	high mobility group box 1	Homo sapiens	18-23
31802434-5	2020	Neutralization of HMGB1 with an anti-HMGB1 monoclonal antibody decreased the incidence of SE and alleviated the severity of seizure activity in DZP-refractory SE, which was mediated by a Toll-like receptor 4 (TLR4)-dependent pathway.	Diazepam	144-147	high mobility group box 1	Homo sapiens	37-42
31802434-5	2020	Neutralization of HMGB1 with an anti-HMGB1 monoclonal antibody decreased the incidence of SE and alleviated the severity of seizure activity in DZP-refractory SE, which was mediated by a Toll-like receptor 4 (TLR4)-dependent pathway.	Diazepam	144-147	toll like receptor 4	Homo sapiens	187-207
31802434-5	2020	Neutralization of HMGB1 with an anti-HMGB1 monoclonal antibody decreased the incidence of SE and alleviated the severity of seizure activity in DZP-refractory SE, which was mediated by a Toll-like receptor 4 (TLR4)-dependent pathway.	Diazepam	144-147	toll like receptor 4	Homo sapiens	209-213
31802434-6	2020	Importantly, anti-HMGB1 mAb reversed DZP-refractory SE with a wide time window, extending the therapeutic window from 30 to 180 min.	Diazepam	37-40	high mobility group box 1	Homo sapiens	18-23
31802434-7	2020	Furthermore, we found the upregulation of plasma HMGB1 level is closely correlated with the therapeutic response of anti-HMGB1 mAb in DZP-refractory SE.	Diazepam	134-137	high mobility group box 1	Homo sapiens	49-54
31802434-7	2020	Furthermore, we found the upregulation of plasma HMGB1 level is closely correlated with the therapeutic response of anti-HMGB1 mAb in DZP-refractory SE.	Diazepam	134-137	high mobility group box 1	Homo sapiens	121-126
31802434-8	2020	All these results indicated that HMGB1 is a potential therapeutic target and a useful predictive biomarker in DZP-refractory SE.	Diazepam	110-113	high mobility group box 1	Homo sapiens	33-38
32102779-7	2020	In parallel, nicotine-related alterations in GABA signaling observed ex vivo were associated with enhanced diazepam-induced inhibition of lateral VTA DA neurons in vivo Targeting KCC2 with the agonist CLP290 normalized diazepam-induced effects on VTA GABA transmission and reduced diazepam consumption following nicotine administration to the control level.	Diazepam	219-227	solute carrier family 12 member 5	Rattus norvegicus	179-183
32102779-7	2020	In parallel, nicotine-related alterations in GABA signaling observed ex vivo were associated with enhanced diazepam-induced inhibition of lateral VTA DA neurons in vivo Targeting KCC2 with the agonist CLP290 normalized diazepam-induced effects on VTA GABA transmission and reduced diazepam consumption following nicotine administration to the control level.	Diazepam	219-227	solute carrier family 12 member 5	Rattus norvegicus	179-183
31712706-12	2019	Partial pharmacological correction of gamma2-mediated IPSCs with diazepam restored total EEG power toward baseline, but had little effect on the abnormal low-frequency peak in the EEG.	Diazepam	65-73	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	38-44
32134726-0	2020	How do CYP2C19*2 and CYP2C19*17 genetic polymorphisms affect the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome?	Diazepam	88-96	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	7-14
32134726-0	2020	How do CYP2C19*2 and CYP2C19*17 genetic polymorphisms affect the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome?	Diazepam	88-96	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	21-28
32134726-3	2020	The objective of our study was to investigate the effect of CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the efficacy and safety of diazepam in patients with AWS.	Diazepam	137-145	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	60-67
32134726-3	2020	The objective of our study was to investigate the effect of CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the efficacy and safety of diazepam in patients with AWS.	Diazepam	137-145	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	74-81
32134726-9	2020	Conclusions Thus, the effects of CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the efficacy of diazepam were demonstrated.	Diazepam	99-107	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	33-40
32134726-9	2020	Conclusions Thus, the effects of CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the efficacy of diazepam were demonstrated.	Diazepam	99-107	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	47-54
31907349-1	2020	Recently, we reported that, in mice, hunger causes the autophagy-dependent release of a protein called "acyl-CoA-binding protein" or "diazepam binding inhibitor" (ACBP/DBI) from cells, resulting in an increase in plasma ACBP concentrations.	Diazepam	134-142	diazepam binding inhibitor	Mus musculus	104-128
31907349-1	2020	Recently, we reported that, in mice, hunger causes the autophagy-dependent release of a protein called "acyl-CoA-binding protein" or "diazepam binding inhibitor" (ACBP/DBI) from cells, resulting in an increase in plasma ACBP concentrations.	Diazepam	134-142	diazepam binding inhibitor	Mus musculus	163-167
31907349-1	2020	Recently, we reported that, in mice, hunger causes the autophagy-dependent release of a protein called "acyl-CoA-binding protein" or "diazepam binding inhibitor" (ACBP/DBI) from cells, resulting in an increase in plasma ACBP concentrations.	Diazepam	134-142	diazepam binding inhibitor	Mus musculus	168-171
31907349-1	2020	Recently, we reported that, in mice, hunger causes the autophagy-dependent release of a protein called "acyl-CoA-binding protein" or "diazepam binding inhibitor" (ACBP/DBI) from cells, resulting in an increase in plasma ACBP concentrations.	Diazepam	134-142	diazepam binding inhibitor	Mus musculus	220-224
32446424-4	2020	The high activity of the CYP3A4 isoenzyme was manifested by fast metabolism for quetiapine and diazepam, which took more than 1 year to normalize after the inducer, phenytoin, was stopped.	Diazepam	95-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-31
31829605-0	2020	Diazepam prodrug stabilizes human aminopeptidase B during lyophilization.	Diazepam	0-8	arginyl aminopeptidase	Homo sapiens	34-50
31299121-7	2019	Our results indicate that chronic diazepam treated animals under latent inhibition did not show anxiety, or changes in hippocampal synaptic transmission, but a significant reduction in NOS-1 expression was observed.	Diazepam	34-42	nitric oxide synthase 1	Rattus norvegicus	185-190
31326501-4	2019	One of the designed chimeric constructs, RsMouse, could be heterologously expressed and displayed improved binding affinities for the known TSPO drugs diazepam, PK11195 and NBD-FGIN-1-27.	Diazepam	151-159	translocator protein	Homo sapiens	140-144
30571982-9	2019	The animals treated with DDS and DZP alone or in combination showed an increase in the number of viable pyramidal cells but only the combination showed a lower number of damaged pyramidal neurons of hippocampal CA3.	Diazepam	33-36	carbonic anhydrase 3	Homo sapiens	211-214
31470770-1	2019	DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein.	Diazepam	10-18	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-3
31470770-1	2019	DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein.	Diazepam	10-18	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	4-8
31470770-1	2019	DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein.	Diazepam	191-199	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	0-3
31470770-1	2019	DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein.	Diazepam	191-199	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	4-8
31575739-0	2019	Photopotentiation of the GABAA receptor with caged diazepam.	Diazepam	51-59	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	25-30
31575739-4	2019	No caged allosteric modulators of the GABAA receptor have been reported so far; to introduce such an investigational approach, we exploited the structural motifs of the benzodiazepinic scaffold to develop a photocaged version of diazepam (CD) that was tested on basolateral amygdala (BLa) pyramidal cells in mouse brain slices.	Diazepam	229-237	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	38-43
31601770-4	2019	Shisa7 also potently enhances the action of diazepam, a classic benzodiazepine, on GABAARs.	Diazepam	44-52	shisa family member 7	Mus musculus	0-6
31601770-5	2019	Genetic deletion of Shisa7 selectively impairs GABAergic transmission and diminishes the effects of diazepam in mice.	Diazepam	100-108	shisa family member 7	Mus musculus	20-26
31080408-0	2019	Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking.	Diazepam	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	21-27
31561018-0	2019	Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway.	Diazepam	0-8	cathelicidin antimicrobial peptide	Mus musculus	92-96
30837282-8	2019	Our results demonstrate that diazepam, which is practically insoluble, can be delivered intranasally with rapid and complete absorption by coadministering avizafone with aminopeptidase B.	Diazepam	29-37	arginyl aminopeptidase	Homo sapiens	170-186
31080408-5	2019	In contrast, both gamma2 and the postsynaptic scaffolding protein gephyrin showed diminished total protein levels following a single DZP treatment in vitro and in mouse cortical tissue.	Diazepam	133-136	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	18-24
31080408-5	2019	In contrast, both gamma2 and the postsynaptic scaffolding protein gephyrin showed diminished total protein levels following a single DZP treatment in vitro and in mouse cortical tissue.	Diazepam	133-136	gephyrin	Mus musculus	66-74
31080408-6	2019	We further identified DZP treatment enhanced phosphorylation of gephyrin Ser270 and increased generation of gephyrin cleavage products.	Diazepam	22-25	gephyrin	Mus musculus	64-72
31080408-6	2019	We further identified DZP treatment enhanced phosphorylation of gephyrin Ser270 and increased generation of gephyrin cleavage products.	Diazepam	22-25	gephyrin	Mus musculus	108-116
31080408-7	2019	Selective immunoprecipitation of gamma2 from cultured neurons revealed enhanced ubiquitination of this subunit following DZP exposure.	Diazepam	121-124	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	33-39
31080408-11	2019	Additional time-series experiments revealed the gephyrin regulating kinase ERK was inactivated by DZP at multiple time points.	Diazepam	98-101	gephyrin	Mus musculus	48-56
31080408-11	2019	Additional time-series experiments revealed the gephyrin regulating kinase ERK was inactivated by DZP at multiple time points.	Diazepam	98-101	mitogen-activated protein kinase 1	Mus musculus	75-78
31080408-12	2019	Moreover, we found DZP simultaneously enhanced synaptic exchange of both gamma2-GABAARs and gephyrin using fluorescence recovery after photobleaching (FRAP) techniques.	Diazepam	19-22	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	73-79
31080408-12	2019	Moreover, we found DZP simultaneously enhanced synaptic exchange of both gamma2-GABAARs and gephyrin using fluorescence recovery after photobleaching (FRAP) techniques.	Diazepam	19-22	gephyrin	Mus musculus	92-100
31080408-13	2019	Finally we provide the first proteomic analysis of the BZD sensitive GABAAR interactome in DZP vs. vehicle treated mice.	Diazepam	91-94	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	69-75
31080408-14	2019	Collectively, our results indicate DZP exposure elicits down-regulation of gephyrin scaffolding and BZD sensitive GABAAR synaptic availability via multiple dynamic trafficking processes.	Diazepam	35-38	gephyrin	Mus musculus	75-83
31080408-14	2019	Collectively, our results indicate DZP exposure elicits down-regulation of gephyrin scaffolding and BZD sensitive GABAAR synaptic availability via multiple dynamic trafficking processes.	Diazepam	35-38	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	114-120
29951207-7	2018	In addition, we also found that 10 days treatment with diazepam but not imidazenil increased the expression of histone deacetylase (HDAC) 1 and 2 in frontal cortex.	Diazepam	55-63	histone deacetylase 1	Rattus norvegicus	111-145
30467864-0	2019	Effect of an anxiolytic botanical containing Souroubea sympetala and Platanus occidentalis on in-vitro diazepam human cytochrome P450-mediated metabolism.	Diazepam	103-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-133
30454851-9	2019	Furthermore, diazepam, as an anxiolytic drug targeting GABAARs, was found to increase gephyrin palmitoylation in the BLA via a GABAAR-dependent manner to activate DHHC12.	Diazepam	13-21	gephyrin	Rattus norvegicus	86-94
30454851-9	2019	Furthermore, diazepam, as an anxiolytic drug targeting GABAARs, was found to increase gephyrin palmitoylation in the BLA via a GABAAR-dependent manner to activate DHHC12.	Diazepam	13-21	zinc finger DHHC-type palmitoyltransferase 12	Rattus norvegicus	163-169
30454851-10	2019	The anxiolytic effect of diazepam was nearly abolished by the DHHC12 knockdown.	Diazepam	25-33	zinc finger DHHC-type palmitoyltransferase 12	Rattus norvegicus	62-68
30699908-4	2019	Therefore, we conducted an investigation based on a radioligand binding assay, to determine the inhibition constants of some reported endogenous TSPO ligands (diazepam binding inhibitor and protoporphyrin IX), as well as synthetic ligands (disulfiram and derivatives).	Diazepam	159-167	translocator protein	Homo sapiens	145-149
30619611-7	2019	In contrast, several benzodiazepines positively modulated phenylephrine stimulation of a cAMP response element pathway by alpha1A- and alpha1B-ARs; however, this was shown to be caused by off-target inhibition of phosphodiesterases, known targets of diazepam.	Diazepam	250-258	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	122-129
29614330-0	2018	Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis.	Diazepam	100-108	cytochrome P450 family 3 subfamily A member 94	Equus caballus	19-26
30026565-6	2018	In Csf1r-cKO mice, inhibitory synaptic transmission is impaired and CF elimination is restored by diazepam, which suggests that impairment of CF elimination is caused by a defect of GABAergic inhibition on PCs, a prerequisite for CF elimination.	Diazepam	98-106	colony stimulating factor 1 receptor	Mus musculus	3-8
30205495-1	2018	The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.	Diazepam	170-178	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-24
30205495-1	2018	The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.	Diazepam	170-178	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-30
29951207-8	2018	Thus, the increased expression of HDAC1 and HDAC2 (class 1 HDACs) and consequently increased histone deacetylation mechanism of this class 1 HDACs, may underlie long-term diazepam-induced decreased expression of the alpha1 GABAA receptor subunit mRNA in frontal cortex.	Diazepam	171-179	histone deacetylase 1	Rattus norvegicus	34-39
29951207-8	2018	Thus, the increased expression of HDAC1 and HDAC2 (class 1 HDACs) and consequently increased histone deacetylation mechanism of this class 1 HDACs, may underlie long-term diazepam-induced decreased expression of the alpha1 GABAA receptor subunit mRNA in frontal cortex.	Diazepam	171-179	histone deacetylase 2	Rattus norvegicus	44-49
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	53-61	heme oxygenase 1	Rattus norvegicus	108-124
28698967-2	2018	Glial cells synthesize and release the octadecaneuropeptide ODN, a diazepam-binding inhibitor (DBI)-related peptide, which acts through its metabotropic receptor to protect neurons and astrocytes from oxidative stress-induced apoptosis.	Diazepam	67-75	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	95-98
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	53-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-164
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	53-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	287-293
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	63-66	heme oxygenase 1	Rattus norvegicus	108-124
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	63-66	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	287-293
29131354-10	2018	Continuous 14-day administration of DZP inhibited Ugt1a1 induction in the cortex, but did not have an effect on Ugt1a7 induction.	Diazepam	36-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	50-56
28992974-4	2017	The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.	Diazepam	26-34	translocator protein	Homo sapiens	206-210
29171003-0	2018	Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.	Diazepam	49-57	monoglyceride lipase	Mus musculus	14-37
29171003-6	2018	METHODS: Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice.	Diazepam	9-17	cannabinoid receptor 1 (brain)	Mus musculus	128-131
29031852-8	2018	Enhancement of GABA signaling by diazepam impeded ocular dominance plasticity rescued by Cdk5 inhibition.	Diazepam	33-41	cyclin-dependent kinase 5	Mus musculus	89-93
28992974-4	2017	The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.	Diazepam	26-34	integrin subunit alpha M	Homo sapiens	255-260
29163035-7	2017	Additionally, we identified Gabra genes as transcriptional targets of NPAS2, found that Npas2 null mutant mice exhibit reduced sensitivity to the GABAa positive allosteric modulator, diazepam and that knockdown of Npas2 reduced Gabra1 expression and response to diazepam in the ventral striatum.	Diazepam	183-191	neuronal PAS domain protein 2	Mus musculus	70-75
29211020-1	2017	Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys.	Diazepam	231-239	translocator protein	Homo sapiens	119-139
29211020-1	2017	Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys.	Diazepam	231-239	translocator protein	Homo sapiens	141-145
28687902-7	2017	In the present study, Diazepam or SAS (0.6 ml/kg/day) treated rats stayed in the illuminated side of the light-dark box, as compare to control rats (Veh, 134.62 +- 4.430 s; SAS 0.6 ml/kg, 192.2 +- 8.11 s; DZP 1.0 mg/kg, 205.21.20 +- 10.26 s, p &lt; 0.05).	Diazepam	205-208	methionine adenosyltransferase 1A	Rattus norvegicus	34-37
28735156-10	2017	RESULTS: By replacing IV narcotic and propofol, with PRN diazepam and vecuronium, patients were off continuous drips in 1week and were able to actively participate in physical therapy.	Diazepam	57-65	cytosolic iron-sulfur assembly component 3	Homo sapiens	53-56
29138471-3	2017	In the absence of alpha1 subunits, a receptor was formed that was gated by GABA and modulated by diazepam similarly.	Diazepam	97-105	adrenoceptor alpha 1D	Homo sapiens	18-24
29138471-6	2017	From this mutation work we conclude that the site for GABA is located at a beta2+/beta2- subunit interface and that the diazepam site is located at the beta2+/gamma2- subunit interface.	Diazepam	120-128	tryptophanyl-tRNA synthetase 1	Homo sapiens	159-165
29138471-8	2017	Thus, the beta2 subunit can take over the role of the alpha1 subunit for the formation of both sites, its minus side for the GABA binding site and its plus side for the diazepam binding site.	Diazepam	169-177	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	10-15
29138471-8	2017	Thus, the beta2 subunit can take over the role of the alpha1 subunit for the formation of both sites, its minus side for the GABA binding site and its plus side for the diazepam binding site.	Diazepam	169-177	adrenoceptor alpha 1D	Homo sapiens	54-60
29163035-7	2017	Additionally, we identified Gabra genes as transcriptional targets of NPAS2, found that Npas2 null mutant mice exhibit reduced sensitivity to the GABAa positive allosteric modulator, diazepam and that knockdown of Npas2 reduced Gabra1 expression and response to diazepam in the ventral striatum.	Diazepam	183-191	neuronal PAS domain protein 2	Mus musculus	88-93
29163035-7	2017	Additionally, we identified Gabra genes as transcriptional targets of NPAS2, found that Npas2 null mutant mice exhibit reduced sensitivity to the GABAa positive allosteric modulator, diazepam and that knockdown of Npas2 reduced Gabra1 expression and response to diazepam in the ventral striatum.	Diazepam	183-191	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	146-151
29163035-7	2017	Additionally, we identified Gabra genes as transcriptional targets of NPAS2, found that Npas2 null mutant mice exhibit reduced sensitivity to the GABAa positive allosteric modulator, diazepam and that knockdown of Npas2 reduced Gabra1 expression and response to diazepam in the ventral striatum.	Diazepam	183-191	neuronal PAS domain protein 2	Mus musculus	214-219
29163035-7	2017	Additionally, we identified Gabra genes as transcriptional targets of NPAS2, found that Npas2 null mutant mice exhibit reduced sensitivity to the GABAa positive allosteric modulator, diazepam and that knockdown of Npas2 reduced Gabra1 expression and response to diazepam in the ventral striatum.	Diazepam	262-270	neuronal PAS domain protein 2	Mus musculus	70-75
29163035-7	2017	Additionally, we identified Gabra genes as transcriptional targets of NPAS2, found that Npas2 null mutant mice exhibit reduced sensitivity to the GABAa positive allosteric modulator, diazepam and that knockdown of Npas2 reduced Gabra1 expression and response to diazepam in the ventral striatum.	Diazepam	262-270	neuronal PAS domain protein 2	Mus musculus	214-219
27231113-3	2017	We describe an interaction between the new anticancer agent idelalisib (CYP 3A4 inhibitor) and diazepam (CYP 3A4 substrate) that resulted in altered mental status and type II respiratory failure resulting in hospitalization.	Diazepam	95-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-79
29163156-7	2017	TSPO ligands showed distinct intracellular effects on LTB4-induced neutrophil locomotion, with diazepam enhancing cofilin but not modifying Arp2/3 expression, and Ro5-4864 and PK11195 reducing both cofilin and Arp2/3 expression.	Diazepam	95-103	translocator protein	Mus musculus	0-4
28426226-12	2017	The high brain uptake of oroxylin A, a GABAA antagonist which had been reported to antagonize diazepam-induced anxiolytic effect, might have suppressed the anxiolytic effects of the other flavones and account for the lack of overall anxiolytic effect of SR extract.	Diazepam	94-102	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	39-44
27231113-3	2017	We describe an interaction between the new anticancer agent idelalisib (CYP 3A4 inhibitor) and diazepam (CYP 3A4 substrate) that resulted in altered mental status and type II respiratory failure resulting in hospitalization.	Diazepam	95-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-112
28042145-9	2017	Cx36 and Cx43 protein expression was assessed by Western blot analysis in the hippocampus of SE-experienced rats, after injection of diazepam (F0 subgroup), after acquisition of focal seizures (F3 subgroup), and after development of generalized seizures (F5 subgroup).	Diazepam	133-141	gap junction protein, delta 2	Rattus norvegicus	0-4
28034961-9	2017	Pharmacological analysis showed that the encounter-induced hyperactivity is mediated by dopamine D1 receptors and 5-HT2A receptors and attenuated by anxiolytics and antidepressants such as diazepam, osemozotan and selective 5-HT reuptake inhibitors.	Diazepam	189-197	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	88-120
28042145-9	2017	Cx36 and Cx43 protein expression was assessed by Western blot analysis in the hippocampus of SE-experienced rats, after injection of diazepam (F0 subgroup), after acquisition of focal seizures (F3 subgroup), and after development of generalized seizures (F5 subgroup).	Diazepam	133-141	gap junction protein, alpha 1	Rattus norvegicus	9-13
28160299-12	2017	Faster recovery from diazepam-induced motor impairment was observed in CD14, TLR4, and MyD88 null mice of both sexes.	Diazepam	21-29	CD14 antigen	Mus musculus	71-75
28436443-7	2017	Finally, mutations at the beta2 or gamma2 subunit predominantly eliminated modulation of recombinant GABAARs by curcumol and menthol, or diazepam, respectively.	Diazepam	137-145	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	26-31
28436443-7	2017	Finally, mutations at the beta2 or gamma2 subunit predominantly eliminated modulation of recombinant GABAARs by curcumol and menthol, or diazepam, respectively.	Diazepam	137-145	tryptophanyl-tRNA synthetase 1	Homo sapiens	35-41
28160299-12	2017	Faster recovery from diazepam-induced motor impairment was observed in CD14, TLR4, and MyD88 null mice of both sexes.	Diazepam	21-29	toll-like receptor 4	Mus musculus	77-81
28160299-12	2017	Faster recovery from diazepam-induced motor impairment was observed in CD14, TLR4, and MyD88 null mice of both sexes.	Diazepam	21-29	myeloid differentiation primary response gene 88	Mus musculus	87-92
28114407-7	2017	We determined agonist properties and modulation by diazepam of two of these receptors that resulted in currents large enough for a characterization, that is, beta2-alpha1-gamma2/alpha1-gamma2 and beta2-alpha1-gamma2/beta2-gamma2.	Diazepam	51-59	tryptophanyl-tRNA synthetase 1 L homeolog	Xenopus laevis	158-191
28596835-0	2017	Chronic diazepam administration increases the expression of Lcn2 in the CNS.	Diazepam	8-16	lipocalin 2	Mus musculus	60-64
28596835-8	2017	We found that the mRNA expression levels were significantly affected by chronic DZP administration and that lipocalin 2 (Lcn2) mRNA was the most upregulated gene in the cerebral cortex, hippocampus, and amygdala.	Diazepam	80-83	lipocalin 2	Mus musculus	108-119
28596835-8	2017	We found that the mRNA expression levels were significantly affected by chronic DZP administration and that lipocalin 2 (Lcn2) mRNA was the most upregulated gene in the cerebral cortex, hippocampus, and amygdala.	Diazepam	80-83	lipocalin 2	Mus musculus	121-125
28596835-12	2017	Our results suggest that chronic DZP administration regulates transcription and upregulates Lcn2 expression levels without an inflammatory response in the mouse brain.	Diazepam	33-36	lipocalin 2	Mus musculus	92-96
28596835-13	2017	Furthermore, the DZP-induced upregulation of Lcn2 expression was influenced by ambient iron.	Diazepam	17-20	lipocalin 2	Mus musculus	45-49
28114407-7	2017	We determined agonist properties and modulation by diazepam of two of these receptors that resulted in currents large enough for a characterization, that is, beta2-alpha1-gamma2/alpha1-gamma2 and beta2-alpha1-gamma2/beta2-gamma2.	Diazepam	51-59	tryptophanyl-tRNA synthetase 1 L homeolog	Xenopus laevis	158-177
29474768-1	2017	Binding of clopidogrel to serum albumin has been characterized in the presence and absence of linoleic acid by equilibrium dialysis method where ranitidine and diazepam were used as specific probes.	Diazepam	160-168	albumin	Homo sapiens	26-39
28982340-2	2017	Originally discovered as a binding site for diazepam outside the CNS, notably in steroidogenic tissue and mononuclear phagocytes, the TSPO"s historical designation was peripheral benzodiazepine receptor.	Diazepam	44-52	translocator protein	Homo sapiens	134-138
28890837-6	2017	She was empirically treated with diazepam and beta-blockers for SPS, which was confirmed by positive glutamic acid decarboxylase (GAD) antibodies.	Diazepam	33-41	glutamate decarboxylase 1	Homo sapiens	101-128
28890837-6	2017	She was empirically treated with diazepam and beta-blockers for SPS, which was confirmed by positive glutamic acid decarboxylase (GAD) antibodies.	Diazepam	33-41	glutamate decarboxylase 1	Homo sapiens	130-133
27875747-6	2017	Such resistance is strongly associated with the overexpression of P-glycoprotein (Pgp), observed in cerebral cortex, hippocampus and striatum while resistance to Pgp nonsubstrate drugs such as carbamazepine, diazepam and levetiracetam is not observed.	Diazepam	208-216	phosphoglycolate phosphatase	Mus musculus	66-80
27875747-6	2017	Such resistance is strongly associated with the overexpression of P-glycoprotein (Pgp), observed in cerebral cortex, hippocampus and striatum while resistance to Pgp nonsubstrate drugs such as carbamazepine, diazepam and levetiracetam is not observed.	Diazepam	208-216	phosphoglycolate phosphatase	Mus musculus	82-85
27875747-6	2017	Such resistance is strongly associated with the overexpression of P-glycoprotein (Pgp), observed in cerebral cortex, hippocampus and striatum while resistance to Pgp nonsubstrate drugs such as carbamazepine, diazepam and levetiracetam is not observed.	Diazepam	208-216	phosphoglycolate phosphatase	Mus musculus	162-165
29098059-0	2017	Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF-kappaB Pathway in Brain.	Diazepam	22-30	mitogen activated protein kinase 3	Rattus norvegicus	98-105
29098059-12	2017	The immunohistochemical signal of iNOS decreased in the DZP and CUR-treated group.	Diazepam	56-59	nitric oxide synthase 2	Rattus norvegicus	34-38
27771371-6	2017	In contrast to pentobarbital anesthesia, the ketamine/diazepam anesthesia potentiated the long-lasting post-anesthesia REM statewith higher muscle tone (REM1) vs. REM state with atonia (REM2).	Diazepam	54-62	RRAD and GEM like GTPase 1	Rattus norvegicus	153-157
27771371-6	2017	In contrast to pentobarbital anesthesia, the ketamine/diazepam anesthesia potentiated the long-lasting post-anesthesia REM statewith higher muscle tone (REM1) vs. REM state with atonia (REM2).	Diazepam	54-62	RRAD and GEM like GTPase 2	Rattus norvegicus	186-190
27771371-7	2017	Whereas both anesthesias prolonged the post-anesthesia REM sleep duration, the long-term prolongation of the REM1 state was demonstrated only after the ketamine/diazepam anesthesia, first due to the increased number of REM1 episodes, and then due to the prolonged REM1 episodes duration.	Diazepam	161-169	RRAD and GEM like GTPase 1	Rattus norvegicus	109-113
27991432-5	2016	The concommitant use of omeprazole/esomeprazole, therefore, could have critical clinical relevance in individualizing medications metabolized primarily by CYP2C19 such as PPI, clopidogrel, phenytoin, cyclophosphamide, thalidomide, citalopram, clonazepam, diazepam, proguanil, tivantinib etc.	Diazepam	255-263	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	155-162
27316553-9	2016	Further, diazepam exposure significantly decreased the levels of neurotransmitters and acetylcholinesterase activity, but increased the monoamine oxidase activity in brain.	Diazepam	9-17	acetylcholinesterase	Rattus norvegicus	87-107
27432008-0	2016	Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam.	Diazepam	101-109	parvalbumin	Rattus norvegicus	8-19
27432008-4	2016	METHODS: We used an unbiased stereological method to examine the impact of peripubertal diazepam treatment on parvalbumin interneuron number in the ventral subiculum, dentate gyrus of the hippocampus and the basolateral amygdala.	Diazepam	88-96	parvalbumin	Rattus norvegicus	110-121
27432008-5	2016	RESULTS: Methylazoxymethanol acetate rats with peripubertal diazepam showed significantly more parvalbumin interneurons (3355+-173 in the ventral subiculum, 1211+-76 in the dentate gyrus) than methylazoxymethanol acetate without diazepam (2375+-109 and 824+-54, respectively).	Diazepam	60-68	parvalbumin	Rattus norvegicus	95-106
27432008-7	2016	CONCLUSIONS: Peripubertal diazepam attenuated the decrease of parvalbumin in the ventral hippocampus of methylazoxymethanol acetate rats.	Diazepam	26-34	parvalbumin	Rattus norvegicus	62-73
27816004-5	2016	This pioneering study revealed that there was an interaction between DZP and TOL, probably by the inhibition of the CYP isoforms (CYP2B6, CYP2C8, CYP2E1, and CYP1A2) involved in the oxidative metabolism of the solvent.	Diazepam	69-72	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	146-152
27816004-5	2016	This pioneering study revealed that there was an interaction between DZP and TOL, probably by the inhibition of the CYP isoforms (CYP2B6, CYP2C8, CYP2E1, and CYP1A2) involved in the oxidative metabolism of the solvent.	Diazepam	69-72	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	158-164
27363924-0	2016	DBI/ACBP loss-of-function does not affect anxiety-like behaviour but reduces anxiolytic responses to diazepam in mice.	Diazepam	101-109	diazepam binding inhibitor	Mus musculus	0-3
27363924-0	2016	DBI/ACBP loss-of-function does not affect anxiety-like behaviour but reduces anxiolytic responses to diazepam in mice.	Diazepam	101-109	diazepam binding inhibitor	Mus musculus	4-8
27363924-2	2016	Diazepam Binding Inhibitor (DBI), also called acyl-CoA binding protein (ACBP), is a ubiquitously expressed protein originally identified based on its ability to displace diazepam from its binding site on the GABAA receptor.	Diazepam	170-178	diazepam binding inhibitor	Mus musculus	0-26
27363924-2	2016	Diazepam Binding Inhibitor (DBI), also called acyl-CoA binding protein (ACBP), is a ubiquitously expressed protein originally identified based on its ability to displace diazepam from its binding site on the GABAA receptor.	Diazepam	170-178	diazepam binding inhibitor	Mus musculus	28-31
27363924-2	2016	Diazepam Binding Inhibitor (DBI), also called acyl-CoA binding protein (ACBP), is a ubiquitously expressed protein originally identified based on its ability to displace diazepam from its binding site on the GABAA receptor.	Diazepam	170-178	diazepam binding inhibitor	Mus musculus	46-70
27363924-2	2016	Diazepam Binding Inhibitor (DBI), also called acyl-CoA binding protein (ACBP), is a ubiquitously expressed protein originally identified based on its ability to displace diazepam from its binding site on the GABAA receptor.	Diazepam	170-178	diazepam binding inhibitor	Mus musculus	72-76
27316553-10	2016	Interestingly, X-rays exposure to diazepam treated rats increased the levels of neurotransmitters, acetylcholinesterase activity and decreased the monoamine oxidase activity.	Diazepam	34-42	acetylcholinesterase	Rattus norvegicus	99-119
27067130-3	2016	Studies with mutant mice harboring diazepam-insensitive alpha-subunits alpha1, alpha2, alpha3, or alpha5 have revealed that alpha2-containing GABAA receptors (alpha2-GABAARs) are required for diazepam-induced anxiolysis, with no evidence for an involvement of any other alpha-subunit, whereas TP003, described as a selective modulator of alpha3-containing GABAA receptors, was shown to be anxiolytic.	Diazepam	192-200	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	79-104
27133574-7	2016	On the contrary, administration of recombinant human IL-1beta weakens the efficacy of diazepam by prolonging its latency to terminate non-prolonged SE.	Diazepam	86-94	interleukin 1 beta	Homo sapiens	53-61
27133574-8	2016	Thus, the present study provides direct evidence that accumulated IL-1beta contributed to the diazepam refractoriness of prolonged SE, and suggests that interleukin-1 receptor is a target for adjunctive control of diazepam-refractory SE.	Diazepam	94-102	interleukin 1 beta	Mus musculus	66-74
27133574-8	2016	Thus, the present study provides direct evidence that accumulated IL-1beta contributed to the diazepam refractoriness of prolonged SE, and suggests that interleukin-1 receptor is a target for adjunctive control of diazepam-refractory SE.	Diazepam	214-222	interleukin 1 beta	Mus musculus	66-74
28255523-0	2016	Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension.	Diazepam	73-81	epoxide hydrolase 2, cytoplasmic	Mus musculus	14-39
27099220-0	2016	Role of CYP2C19 gene polymorphism in acute alcohol withdrawal treatment with loading dose of diazepam in a South Indian population.	Diazepam	93-101	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	8-15
27099220-2	2016	We studied the effect of CYP2C19 gene polymorphisms on diazepam loading dose requirement and time to reversal of acute alcohol withdrawal symptoms.	Diazepam	55-63	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	25-32
27081794-6	2016	Using circular dichroism, X-ray photoelectron spectroscopy and computer simulations, we demonstrated that a low concentration of La(III) could interact with extracellular CaM by electrostatic attraction and was then bound to two Ca-binding sites of CaM, making the molecular structure more compact and orderly, whereas a high concentration of La(III) could be coordinated with cytoplasmic CaM or bound to other Ca-binding sites, making the molecular structure more loose and disorderly.	Diazepam	129-136	calmodulin 1	Homo sapiens	171-174
27081794-6	2016	Using circular dichroism, X-ray photoelectron spectroscopy and computer simulations, we demonstrated that a low concentration of La(III) could interact with extracellular CaM by electrostatic attraction and was then bound to two Ca-binding sites of CaM, making the molecular structure more compact and orderly, whereas a high concentration of La(III) could be coordinated with cytoplasmic CaM or bound to other Ca-binding sites, making the molecular structure more loose and disorderly.	Diazepam	129-136	calmodulin 1	Homo sapiens	249-252
27081794-6	2016	Using circular dichroism, X-ray photoelectron spectroscopy and computer simulations, we demonstrated that a low concentration of La(III) could interact with extracellular CaM by electrostatic attraction and was then bound to two Ca-binding sites of CaM, making the molecular structure more compact and orderly, whereas a high concentration of La(III) could be coordinated with cytoplasmic CaM or bound to other Ca-binding sites, making the molecular structure more loose and disorderly.	Diazepam	129-136	calmodulin 1	Homo sapiens	249-252
27081794-6	2016	Using circular dichroism, X-ray photoelectron spectroscopy and computer simulations, we demonstrated that a low concentration of La(III) could interact with extracellular CaM by electrostatic attraction and was then bound to two Ca-binding sites of CaM, making the molecular structure more compact and orderly, whereas a high concentration of La(III) could be coordinated with cytoplasmic CaM or bound to other Ca-binding sites, making the molecular structure more loose and disorderly.	Diazepam	343-350	calmodulin 1	Homo sapiens	171-174
27081794-6	2016	Using circular dichroism, X-ray photoelectron spectroscopy and computer simulations, we demonstrated that a low concentration of La(III) could interact with extracellular CaM by electrostatic attraction and was then bound to two Ca-binding sites of CaM, making the molecular structure more compact and orderly, whereas a high concentration of La(III) could be coordinated with cytoplasmic CaM or bound to other Ca-binding sites, making the molecular structure more loose and disorderly.	Diazepam	343-350	calmodulin 1	Homo sapiens	249-252
27081794-6	2016	Using circular dichroism, X-ray photoelectron spectroscopy and computer simulations, we demonstrated that a low concentration of La(III) could interact with extracellular CaM by electrostatic attraction and was then bound to two Ca-binding sites of CaM, making the molecular structure more compact and orderly, whereas a high concentration of La(III) could be coordinated with cytoplasmic CaM or bound to other Ca-binding sites, making the molecular structure more loose and disorderly.	Diazepam	343-350	calmodulin 1	Homo sapiens	249-252
28255523-12	2016	Furthermore, we demonstrate that stabilization of EpFAs by inhibiting sEH is a novel approach to overcome DZP-induced hypotension and this beneficial effect can be enhanced by an omega three diet probably acting through epoxide metabolites of the fatty acids.	Diazepam	106-109	epoxide hydrolase 2, cytoplasmic	Mus musculus	70-73
25968977-8	2015	Benzodiazepine diazepam partially prevented decrease in cell survival following exposure to CS and redox active iron containing media (saliva) while benzodiazepine clonazepam did not, indicating that this effect is TSPO-specific.	Diazepam	15-23	translocator protein	Homo sapiens	215-219
26880548-1	2016	Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans.	Diazepam	70-78	acyl-CoA binding domain containing 7	Homo sapiens	0-36
26880548-1	2016	Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans.	Diazepam	70-78	acyl-CoA binding domain containing 7	Homo sapiens	38-43
26525567-9	2016	Allopregnanolone and diazepam similarly increased total entries in the elevated plus-maze, indicating that behavioral activation may be a general property of GABAA receptor PAMs in these strains.	Diazepam	21-29	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	158-163
26926965-9	2016	Finally, we find that treating Rac1 cKO mice with diazepam in early postnatal life can reverse changes in dendritic morphology observed in non-treated Rac1 cKO mice.	Diazepam	50-58	Rac family small GTPase 1	Mus musculus	31-35
26926965-9	2016	Finally, we find that treating Rac1 cKO mice with diazepam in early postnatal life can reverse changes in dendritic morphology observed in non-treated Rac1 cKO mice.	Diazepam	50-58	Rac family small GTPase 1	Mus musculus	151-155
26875558-1	2016	Diazepam binds with the same high affinity to the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor, which has been renamed translocator protein (TSPO).	Diazepam	0-8	cannabinoid receptor 1	Rattus norvegicus	50-81
26875558-1	2016	Diazepam binds with the same high affinity to the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor, which has been renamed translocator protein (TSPO).	Diazepam	0-8	cannabinoid receptor 1	Rattus norvegicus	83-86
26875558-1	2016	Diazepam binds with the same high affinity to the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor, which has been renamed translocator protein (TSPO).	Diazepam	0-8	translocator protein	Rattus norvegicus	155-175
26875558-1	2016	Diazepam binds with the same high affinity to the central benzodiazepine receptor (CBR) and the peripheral benzodiazepine receptor, which has been renamed translocator protein (TSPO).	Diazepam	0-8	translocator protein	Rattus norvegicus	177-181
26875558-6	2016	In addition, we found that the inhibitory effect of diazepam was also completely blocked by pretreatment with a specific CBR antagonist, flumazenil.	Diazepam	52-60	cannabinoid receptor 1	Rattus norvegicus	121-124
26875558-8	2016	Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL.	Diazepam	37-45	interleukin 1 beta	Rattus norvegicus	138-155
26875558-8	2016	Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL.	Diazepam	37-45	interleukin 1 beta	Rattus norvegicus	157-165
26875558-9	2016	These results suggest that in addition to exerting effects on CBR, diazepam may inhibit neuropathic pain via TSPO, which promotes neurosteroid formation, subsequently reducing the activation of astrocytes and production of cytokines.	Diazepam	67-75	translocator protein	Rattus norvegicus	109-113
26612620-3	2016	OBJECTIVES: We tested the hypothesis that the GABAA receptor benzodiazepine-site (BDZ) negative modulator Ro15-4513 would reduce the reward-related effects of three pharmacologically dissimilar drugs; toluene vapor, d-methamphetamine, and diazepam using intracranial self-stimulation (ICSS) in mice.	Diazepam	239-247	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	46-51
26679806-6	2015	In addition, in the membrane vesicles an inhibition of the transport of the Bsep substrate taurocholic acid could be observed in the presence of diazepam and its metabolites.	Diazepam	145-153	ATP binding cassette subfamily B member 11	Canis lupus familiaris	76-80
25725334-2	2015	In mice, Wfs1 deficiency cause higher anxiety-like behaviour and increased response to anxiolytic-like effect of diazepam, a GABAA receptor agonist.	Diazepam	113-121	wolframin ER transmembrane glycoprotein	Mus musculus	9-13
26594153-6	2015	The fast-acting "antidepressant" ketamine, the mood stabilizer lithium, and brain-derived neurotrophic factor (BDNF) exerted comparable enhancing effects, whereas the antipsychotic haloperidol and the anxiolytic diazepam attenuated HTC-Waves.	Diazepam	212-220	brain derived neurotrophic factor	Mus musculus	111-115
26313333-2	2015	Here, a solid-phase microextraction (SPME) coating that combines octadecyl and propylsulfonic acid groups as strong cation exchange sites, known as C18/SCX or "mixed-mode" SPME, is used to measure freely dissolved concentrations of amitriptyline, amphetamine, diazepam and tramadol to different binding matrices, including bovine serum albumin (BSA), human serum albumin (HSA), human plasma and human whole blood.	Diazepam	260-268	Bardet-Biedl syndrome 9	Homo sapiens	148-151
23572393-1	2015	The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone.	Diazepam	113-121	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
23572393-1	2015	The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone.	Diazepam	113-121	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
23572393-3	2015	The results showed marked inhibition of AchE by diazepam and the values of aKm and aVm were 65.5% and 52.63%, respectively.	Diazepam	48-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-44
23572393-6	2015	It is concluded that diazepam and phenobarbitone exhibited prominent AchE attenuation apart from their well-established antidepressant activity, which could be more useful in related diseased conditions.	Diazepam	21-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
25482686-0	2015	Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam.	Diazepam	151-159	dopamine receptor D3	Mus musculus	0-20
25482686-0	2015	Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam.	Diazepam	151-159	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	42-48
25482686-7	2015	Diazepam treatment did not modify alpha6 expression in D3R(-/-), but progressively increased alpha6 expression in WT, to the level of untreated D3R(-/-) after 14-21 day-treatment.	Diazepam	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	93-99
25482686-8	2015	BDNF mRNA expression in striatum was remarkably (&gt;10-fold) increased after 3 days of diazepam-treatment in both WT and D3R(-/-); such expression level, however, slowly declined below control levels, by 14-21 days.	Diazepam	88-96	brain derived neurotrophic factor	Mus musculus	0-4
26020462-0	2015	Extreme Duration of Diazepam-Associated Sedation in a Patient With Alcohol Delirium and CYP2C19 Polymorphisms.	Diazepam	20-28	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	88-95
25840741-7	2015	Neither in the DPAG nor hippocampus did long-term treatment with the standard anxiolytics diazepam, clonazepam or buspirone affect BDNF levels.	Diazepam	90-98	brain-derived neurotrophic factor	Rattus norvegicus	131-135
25307869-8	2015	Treatment with neuroleptics expressed in chlorpromazine equivalents and benzodiazepines expressed in diazepam equivalents correlated negatively with the number of oligodendrocytes in CA2/3 and CA4, respectively, suggesting that treatment with these drugs do not influence cell number.	Diazepam	101-109	carbonic anhydrase 2	Homo sapiens	183-188
25307869-8	2015	Treatment with neuroleptics expressed in chlorpromazine equivalents and benzodiazepines expressed in diazepam equivalents correlated negatively with the number of oligodendrocytes in CA2/3 and CA4, respectively, suggesting that treatment with these drugs do not influence cell number.	Diazepam	101-109	carbonic anhydrase 4	Homo sapiens	193-196
25149366-5	2014	Accordingly, the anxiolytic effects of 1.0mg/kg diazepam, other GABA(A) acting drug, were significantly enhanced in MK-/- mice compared to MK+/+ mice; however, 2.0mg/kg diazepam caused increased anxiolytic effects in MK+/+ mice.	Diazepam	48-56	midkine	Mus musculus	116-118
25927918-6	2015	In whole-cell recordings in rat brain slices, diazepam (1 muM), an allosteric positive modulator of GABAA receptors, alone enhanced the spontaneous inhibitory postsynaptic current (sIPSC) amplitude and frequency by a factor of 1.3 and 1.6, respectively, and doubled the tonic GABAA current normally recorded in the CA3 pyramidal cells.	Diazepam	46-54	carbonic anhydrase 3	Rattus norvegicus	315-318
25510230-5	2015	The currents were activated by THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and enhanced by the benzodiazepine diazepam (1 muM) and the general anesthetics etomidate and propofol (50 muM).	Diazepam	120-128	latexin	Homo sapiens	132-135
25510230-5	2015	The currents were activated by THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and enhanced by the benzodiazepine diazepam (1 muM) and the general anesthetics etomidate and propofol (50 muM).	Diazepam	120-128	latexin	Homo sapiens	192-195
25553641-7	2015	VEO and diazepam significantly increased c-fos expression in the lateral division of the central amygdaloid nucleus (CeL).	Diazepam	8-16	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-46
25841786-3	2015	Our results show elevated Drd2 expression levels in the nucleus accumbens (NAcc) of prenatally stressed rats compared to control subjects, while repeated diazepam administration in adulthood down-regulated Drd2 expression and prevented the effect of prenatal stress.	Diazepam	154-162	dopamine receptor D2	Rattus norvegicus	206-210
25453777-0	2015	Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.	Diazepam	36-44	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	80-85
25453777-10	2015	When NS-398 was administered with diazepam, decreased neuronal damage was further obtained in all areas investigated (CA1: 61%, CA3: 63%, hilus: 60%).	Diazepam	34-42	carbonic anhydrase 1	Rattus norvegicus	118-121
25453777-10	2015	When NS-398 was administered with diazepam, decreased neuronal damage was further obtained in all areas investigated (CA1: 61%, CA3: 63%, hilus: 60%).	Diazepam	34-42	carbonic anhydrase 3	Rattus norvegicus	128-131
25453777-12	2015	Administration of diazepam with NS-398 potentiates the neuroprotective effect of the COX-2 inhibitor.	Diazepam	18-26	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	85-90
25961707-0	2015	Stabilization of Human Serum Albumin against Urea Denaturation by Diazepam and Ketoprofen.	Diazepam	66-74	albumin	Homo sapiens	23-36
25961707-1	2015	Stabilizing effect of diazepam and ketoprofen, Sudlow"s site II markers on human serum albumin (HSA) against urea denaturation was studied using fluorescence spectroscopy.	Diazepam	22-30	albumin	Homo sapiens	81-94
25471569-12	2014	Using nonstationary fluctuation analysis and diazepam to manipulate GABAA receptor apparent affinity, the decrease in arcuate miniature postsynaptic current amplitude was attributed to decreased number of receptors bound by GABA.	Diazepam	45-53	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	68-73
25149366-5	2014	Accordingly, the anxiolytic effects of 1.0mg/kg diazepam, other GABA(A) acting drug, were significantly enhanced in MK-/- mice compared to MK+/+ mice; however, 2.0mg/kg diazepam caused increased anxiolytic effects in MK+/+ mice.	Diazepam	48-56	midkine	Mus musculus	139-141
25149366-5	2014	Accordingly, the anxiolytic effects of 1.0mg/kg diazepam, other GABA(A) acting drug, were significantly enhanced in MK-/- mice compared to MK+/+ mice; however, 2.0mg/kg diazepam caused increased anxiolytic effects in MK+/+ mice.	Diazepam	48-56	midkine	Mus musculus	139-141
25558239-0	2014	Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury.	Diazepam	11-19	carbonic anhydrase 1	Rattus norvegicus	78-81
25558239-5	2014	Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	86-89
25558239-6	2014	These data suggest that diazepam could decrease the fluid percussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.	Diazepam	24-32	carbonic anhydrase 1	Rattus norvegicus	155-158
25277376-7	2014	RESULTS: We discovered that spinal nerve ligation (SNL) produced neuropathic pain-related anxiety-like behaviors in rats, which could be specifically inhibited by intra-CeA administration of anti-anxiety drug diazepam.	Diazepam	209-217	carcinoembryonic antigen gene family 4	Rattus norvegicus	169-172
25026356-7	2014	In the intracellular LDH and G6PD assays, the EC50 of diazepam was found to be 3.307 and 1.53 mM, while the values of amiodarone were 0.853 and 0.325 mM, respectively.	Diazepam	54-62	glucose-6-phosphate dehydrogenase	Homo sapiens	29-33
25466558-9	2014	Surprisingly, the positive allosteric modulator diazepam abolished the regulation induced by muscimol, and this effect was observed on alpha1, alpha2, alpha5 and gamma2 GABA(A)R subunits.	Diazepam	48-56	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	169-177
25466558-10	2014	Altogether these results indicate that diazepam stabilizes synaptic GABA(A)Rs and thus prevents the agonist-induced regulation of GABA(A)R levels at synapses.	Diazepam	39-47	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	68-76
24927827-6	2014	Significantly less deposition of Abeta in the CA1 area of the hippocampus and frontal cortex of mice exposed to isoflurane, propofol, diazepam, ketamine, and pentobarbital was observed.	Diazepam	134-142	amyloid beta (A4) precursor protein	Mus musculus	33-38
25240770-0	2014	Paradoxical response to the sedative effects of diazepam and alcohol in C57BL/6J mice lacking the neuropeptide S receptor.	Diazepam	48-56	neuropeptide S receptor 1	Mus musculus	98-121
25240770-5	2014	Contrary to our expectations, the results showed that the NPSR(-/-) were less sensitive to the hypnotic effects of both diazepam and ethanol compared with their wild type littermates.	Diazepam	120-128	neuropeptide S receptor 1	Mus musculus	58-62
25004465-6	2014	Hypoosmolarity, NH4Cl (0.5-5 mmol/l), diazepam (10 mumol/l) and TNFalpha (10 ng/ml) time-dependently decreased mRNA expression of SMIT and/or TauT in cultured astrocytes.	Diazepam	38-46	solute carrier family 5 member 3	Rattus norvegicus	130-134
25004465-6	2014	Hypoosmolarity, NH4Cl (0.5-5 mmol/l), diazepam (10 mumol/l) and TNFalpha (10 ng/ml) time-dependently decreased mRNA expression of SMIT and/or TauT in cultured astrocytes.	Diazepam	38-46	solute carrier family 6 member 6	Homo sapiens	142-146
25297674-5	2014	Enhancing cortical gamma-aminobutyric acid (GABA) inhibition with diazepam infusion can restore critical period plasticity in both young and adult PV-Mecp2(-/y) mice.	Diazepam	66-74	methyl CpG binding protein 2	Mus musculus	150-155