PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35445947-9	2022	Our data suggest that monensin downregulates cholesterol synthesis via inhibition of HMGCS-1 and impairment of the SREBP pathway, probably due to a crosstalk among different tissues to control energy metabolism.	Monensin	22-30	hydroxymethylglutaryl-CoA synthase, cytoplasmic	Ovis aries	85-92
2675782-5	1989	Immunolocalisation of MMP-3 in rheumatoid synovium and cultured synovial cells was possible when the specimens were treated with a monovalent ionophore, monensin.	Monensin	153-161	matrix metallopeptidase 3	Homo sapiens	22-27
35124357-9	2022	The analysis of six vinasse samples from different ethanol producing plants led to the detection of monensin at the concentration of 14.3 ng mL-1 in their compositions.	Monensin	100-108	L1 cell adhesion molecule	Mus musculus	141-145
35378374-12	2022	Monensin did not affect amyloidogenic-related proteins or NHE6 directly; therefore, ketamine-promoted endosomal amyloidogenic processing and BACE1 accumulation were depleted by restoring endosomal acidity through monensin pretreatment.	Monensin	0-8	beta-secretase 1	Homo sapiens	141-146
35378374-12	2022	Monensin did not affect amyloidogenic-related proteins or NHE6 directly; therefore, ketamine-promoted endosomal amyloidogenic processing and BACE1 accumulation were depleted by restoring endosomal acidity through monensin pretreatment.	Monensin	213-221	beta-secretase 1	Homo sapiens	141-146
35168524-0	2022	Monensin inhibits anaplastic thyroid cancer via disrupting mitochondrial respiration and AMPK/mTOR signaling.	Monensin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	89-93
35168524-0	2022	Monensin inhibits anaplastic thyroid cancer via disrupting mitochondrial respiration and AMPK/mTOR signaling.	Monensin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	94-98
35168524-5	2022	Mitochondrial biogenesis profiles, ATP levels, oxidative stress, AMPK and mTOR were examined in these cells after monensin treatment.	Monensin	114-122	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	65-69
2513867-3	1989	Secretion of VIII:C by cultured LEC was inhibited by cycloheximide and by monensin.	Monensin	74-82	cytochrome c oxidase subunit 8A	Homo sapiens	13-17
2526734-7	1989	It was found to have a marked effect on the synthesis of O-linked carbohydrate structures of leukosialin since the amount of O-glycans containing only GalNAc or NeuNAc alpha 2----6GalNAc was significantly increased after monensin treatment.	Monensin	221-229	LOC105369247	Homo sapiens	93-104
2838354-10	1988	The lysosomotropic drugs monensin and chloroquine caused intracellular accumulation of insulin and its receptors internalized at low concentrations of insulin but had a relatively smaller effect on receptors internalized at high concentrations of insulin.	Monensin	25-33	insulin	Homo sapiens	87-94
2744008-1	1989	The effect of pH on the secretion of the gp 80 glycoprotein complex and lysozyme from MDCK cells was examined by treatment of the cells with either NH4Cl, chloroquine or monensin.	Monensin	170-178	clusterin	Canis lupus familiaris	41-46
2501124-6	1989	Low concentrations of monensin accelerated basal (0.03 microM and 0.1 microM) and GRF-stimulated (0.03 microM) [3H]rGH and [3H]rPRL release without altering recovery; higher monensin concentrations (greater than or equal to 1 microM) reduced basal, and abolished GRF-stimulated, new hormone release and reduced total [3H]rGH and [3H]rPRL recovery.	Monensin	22-30	growth hormone releasing hormone	Rattus norvegicus	82-85
2501124-6	1989	Low concentrations of monensin accelerated basal (0.03 microM and 0.1 microM) and GRF-stimulated (0.03 microM) [3H]rGH and [3H]rPRL release without altering recovery; higher monensin concentrations (greater than or equal to 1 microM) reduced basal, and abolished GRF-stimulated, new hormone release and reduced total [3H]rGH and [3H]rPRL recovery.	Monensin	22-30	growth hormone releasing hormone	Rattus norvegicus	263-266
2501124-6	1989	Low concentrations of monensin accelerated basal (0.03 microM and 0.1 microM) and GRF-stimulated (0.03 microM) [3H]rGH and [3H]rPRL release without altering recovery; higher monensin concentrations (greater than or equal to 1 microM) reduced basal, and abolished GRF-stimulated, new hormone release and reduced total [3H]rGH and [3H]rPRL recovery.	Monensin	174-182	growth hormone releasing hormone	Rattus norvegicus	82-85
2834074-6	1988	Efficient alpha-MSH pulsing was also impaired by treatment of the APC with the carboxylic ionophore, monensin, but not by the lysosomotropic agents chloroquine and methylamine.	Monensin	101-109	proopiomelanocortin	Homo sapiens	10-19
2656861-9	1989	The processing of HI both at the plasma membrane and intracellularly was inhibited by chloroquine, monensin, and NH4Cl, suggesting that both intracellular pH changes and endocytic and exocytic events may be required for these compartments to process insulin.	Monensin	99-107	insulin	Homo sapiens	250-257
3042455-1	1988	Tyrosine sulfation of entactin was studied by labeling of 3T3-L1 adipocytes with [35S]methionine or H2 35SO4 in the presence or absence of tunicamycin or monensin.	Monensin	154-162	nidogen 1	Homo sapiens	22-30
2838354-10	1988	The lysosomotropic drugs monensin and chloroquine caused intracellular accumulation of insulin and its receptors internalized at low concentrations of insulin but had a relatively smaller effect on receptors internalized at high concentrations of insulin.	Monensin	25-33	insulin	Homo sapiens	151-158
2838354-10	1988	The lysosomotropic drugs monensin and chloroquine caused intracellular accumulation of insulin and its receptors internalized at low concentrations of insulin but had a relatively smaller effect on receptors internalized at high concentrations of insulin.	Monensin	25-33	insulin	Homo sapiens	151-158
3264995-9	1988	Human diferric transferrin linked to RTA exhibited a potent cytotoxic effect against human glioma-derived cells when used in the presence of the lysosomotropic carboxylic ionophore monensin.	Monensin	181-189	transferrin	Homo sapiens	15-26
2831223-3	1988	Several observations indicate that the exchanger is regulated by protein kinase C. (i) Inhibitors of protein kinase C (trifluoperazine, sphingosine) inhibit the increase in pHi seen during thrombin stimulation as well as Ca2+ mobilization; artificially increasing pHi by monensin or NH4Cl then restores Ca2+ mobilization.	Monensin	271-279	glucose-6-phosphate isomerase	Homo sapiens	173-176
2831223-3	1988	Several observations indicate that the exchanger is regulated by protein kinase C. (i) Inhibitors of protein kinase C (trifluoperazine, sphingosine) inhibit the increase in pHi seen during thrombin stimulation as well as Ca2+ mobilization; artificially increasing pHi by monensin or NH4Cl then restores Ca2+ mobilization.	Monensin	271-279	coagulation factor II, thrombin	Homo sapiens	189-197
2831223-6	1988	In the absence of thrombin an increase in pHi, either induced artificially (by addition of the ionophores nigericin or monensin) or via activation of protein kinase C (by addition of 1-oleoyl-2-acetylglycerol), does not induce Ca2+ mobilization.	Monensin	119-127	glucose-6-phosphate isomerase	Homo sapiens	42-45
3128323-5	1988	After 2 h of incubation of the cells in the presence of ionophore and Ca2+, the released acrosin activity is related to the ionophores according to the sequence: A23187 greater than monensin greater than valinomycin greater than FCCP = without ionophore.	Monensin	182-190	acrosin	Homo sapiens	89-96
3264995-9	1988	Human diferric transferrin linked to RTA exhibited a potent cytotoxic effect against human glioma-derived cells when used in the presence of the lysosomotropic carboxylic ionophore monensin.	Monensin	181-189	RNA binding fox-1 homolog 2	Homo sapiens	37-40
3498854-8	1987	Similar potentiation of the cytotoxicity of anti-CEA immunotoxins was produced by monensin and nigericin.	Monensin	82-90	CEA cell adhesion molecule 3	Homo sapiens	49-52
2439368-6	1987	However, the amount of gPr80env associated with the TX-soluble fraction in both CB or monensin-treated and untreated cells labeled with [3H]leucine was about the same.	Monensin	86-94	oxoglutarate receptor 1	Homo sapiens	23-28
3038198-6	1987	The inhibitory effect of protein kinase C activators and bradykinin on cAMP generation was reversed by the protein kinase C inhibitor H7, was enhanced by monensin, one effect of which is to block the recycling of membrane receptors, and persisted when the GTP-binding protein N1 was blocked with 1 mM Mn2+.	Monensin	154-162	kininogen 1	Canis lupus familiaris	57-67
2434485-4	1987	Inhibitors of receptor recycling, chloroquine, monensin, and colchicine, inhibited uptake of apoA-I from HDL by Hep G-2 human hepatoma cells to about the same extent as a reference protein, asialofetuin, but inhibited uptake of the cholesteryl ether tracer much less.	Monensin	47-55	apolipoprotein A1	Homo sapiens	93-99
3311030-7	1987	Formation of betagranin and insulin from their respective precursors followed a parallel course and could likewise be inhibited by NH4+, chloroquine and monensin, added either before labelling or at any point of time up to 15 min after labelling.	Monensin	153-161	insulin	Homo sapiens	28-35
3551268-2	1987	The number of amines (dansylcadaverine, chloroquine, cystamine, 5-methoxytryptamine) dimethylurea and monensin were shown to block the mitogenic effect of EGF.	Monensin	102-110	epidermal growth factor	Mus musculus	155-158
3546340-7	1987	Ammonium chloride or monensin reduced the release of 125I-GM-CSF from the cells, suggesting that the receptor-bound ligand was processed through the lysosomes.	Monensin	21-29	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	58-64
3027576-4	1987	We also demonstrate that cytoplasmic alkalinization produced by exposure to the ionophore monensin sensitizes the human platelet response to stimulation by thrombin resulting in enhanced Ca2+ mobilization and aggregability.	Monensin	90-98	coagulation factor II, thrombin	Homo sapiens	156-164
2944781-8	1986	Chloroquine and monensin, which act at the lysosomes and at other sites, increased both cell-associated IGF II and insulin and decreased the degradation of both hormones.	Monensin	16-24	insulin like growth factor 2	Bos taurus	104-110
2876919-1	1986	The biosynthesis and post-translational processing of sucrase-isomaltase and dipeptidylpeptidase IV were studied by L-[35S]methionine labeling, immunoisolation with monoclonal antibodies and SDS-PAGE in post-confluent Caco-2 cells treated with monensin (10 microM, 48 h).	Monensin	244-252	sucrase-isomaltase	Homo sapiens	54-72
2944781-8	1986	Chloroquine and monensin, which act at the lysosomes and at other sites, increased both cell-associated IGF II and insulin and decreased the degradation of both hormones.	Monensin	16-24	insulin	Bos taurus	115-122
4052441-7	1985	The immunoadsorbable lipoprotein lipase in the intracellular compartment has a [14C]mannose to [3H]galactose ratio of 0.15 and this ratio increased 6-fold in monensin-treated cells.	Monensin	158-166	lipoprotein lipase	Rattus norvegicus	21-39
3011246-0	1986	Selective killing of human T-lymphotropic virus-I infected leukemic T-cells by monoclonal anti-interleukin 2 receptor antibody-ricin A chain conjugates: potentiation by ammonium chloride and monensin.	Monensin	191-199	interleukin 2	Homo sapiens	95-108
3011246-6	1986	Addition of ammonium chloride or monensin augments the potency of anti-TAC-A killing 100-fold (50% inhibitory concentration = 2.5 X 10(-12) M) and 400-fold (50% inhibitory concentration = 8 X 10(-13) M), respectively; furthermore, these agents accelerate rate of anti-TAC-A intoxication and increase the specific killing of interleukin 2 receptor-bearing leukemic cells.	Monensin	33-41	interleukin 2	Homo sapiens	324-337
3539101-4	1986	The phorbol-ester-induced enhancement of internalized insulin in HepG2 cells was additive with the potentiation of endocytosed insulin induced by both the lysosomotropic reagent chloroquine and the ionophore monensin; this indicates that TPA affects the intracellular processing of the insulin receptor at a point other than those disrupted by either of these two reagents.	Monensin	208-216	insulin	Homo sapiens	54-61
3539101-4	1986	The phorbol-ester-induced enhancement of internalized insulin in HepG2 cells was additive with the potentiation of endocytosed insulin induced by both the lysosomotropic reagent chloroquine and the ionophore monensin; this indicates that TPA affects the intracellular processing of the insulin receptor at a point other than those disrupted by either of these two reagents.	Monensin	208-216	insulin	Homo sapiens	127-134
6094573-8	1984	Cell-surface-binding sites for transferrin were reduced by 50% with 10(-5) M monensin treatment; however, this effect was not attenuated by 80% protein synthesis inhibition with cycloheximide, supporting the idea that the transferrin receptor is also recycled through the Golgi.	Monensin	77-85	transferrin	Homo sapiens	31-42
3932522-2	1985	In the presence of monensin or nigericin, which exchange H+ for Na+ or K+, respectively, through bio-membrane, the tyrosinase activity of cells in culture was more than 10 times that in the control culture.	Monensin	19-27	tyrosinase	Mus musculus	115-125
3079667-3	1986	Induction involved a sequence of transcription, translation, and secretion, all necessary for HMT synthesis and release into the supernatant as determined by blocking of these functions with the drugs actinomycin D, cycloheximide, and monensin, respectively; HMT levels reached a peak within 4-6 h and thereafter declined.	Monensin	235-243	histamine N-methyltransferase	Homo sapiens	94-97
3861610-12	1985	The carboxylic ionophore, monensin, caused the accumulation of incompletely O-glycosylated glycophorin A molecules, which bound to H. pomatia lectin-Sepharose.	Monensin	26-34	glycophorin A (MNS blood group)	Homo sapiens	91-104
3884603-13	1985	Based on these observations and on the reported biological effects of monensin, it is suggested (a) that monensin may induce intracellular accumulation of the insulin-receptor complex by blocking the acidification of endocytic vesicles and (b) that the accumulated insulin-receptor complex may retain a weak, but significant, capacity to stimulate both glucose transport and phosphodiesterase activities.	Monensin	70-78	insulin receptor	Rattus norvegicus	159-175
3884603-13	1985	Based on these observations and on the reported biological effects of monensin, it is suggested (a) that monensin may induce intracellular accumulation of the insulin-receptor complex by blocking the acidification of endocytic vesicles and (b) that the accumulated insulin-receptor complex may retain a weak, but significant, capacity to stimulate both glucose transport and phosphodiesterase activities.	Monensin	105-113	insulin receptor	Rattus norvegicus	159-175
3884603-13	1985	Based on these observations and on the reported biological effects of monensin, it is suggested (a) that monensin may induce intracellular accumulation of the insulin-receptor complex by blocking the acidification of endocytic vesicles and (b) that the accumulated insulin-receptor complex may retain a weak, but significant, capacity to stimulate both glucose transport and phosphodiesterase activities.	Monensin	105-113	insulin receptor	Rattus norvegicus	265-281
6094573-8	1984	Cell-surface-binding sites for transferrin were reduced by 50% with 10(-5) M monensin treatment; however, this effect was not attenuated by 80% protein synthesis inhibition with cycloheximide, supporting the idea that the transferrin receptor is also recycled through the Golgi.	Monensin	77-85	transferrin receptor	Homo sapiens	222-242
6389542-3	1984	Monensin, a monocarboxylic acid ionophore, has been used to characterize the role of recycling in the metabolism of insulin receptors on two cultured human cell lines, U-937 and IM-9, which have different rates of internalization.	Monensin	0-8	insulin	Homo sapiens	116-123
6095295-6	1984	These changes of pHc were blocked when ouabain-treated glands had been preequilibrated for 10 min with 1 mM amiloride, and this block was overcome by adding 10 microM monensin (an ionophore that artificially exchanges Na+ for H+).	Monensin	167-175	solute carrier family 25 member 3	Homo sapiens	17-20
6477962-7	1984	However, using labeled amino acids, it was shown by autoradiography and by immunoprecipitation that secretion of newly-synthesized, radioactive apolipoprotein A-I and apolipoprotein C was actually inhibited by monensin.	Monensin	210-218	apolipoprotein A1	Rattus norvegicus	144-183
6092339-6	1984	Mr = 160,000 receptors resulting from swainsonine or monensin treatment were present on the cell surface and retained full function, as judged by 125I-EGF binding to intact cells and detergent-solubilized extracts and by in vitro phosphorylation in the absence or presence of EGF.	Monensin	53-61	epidermal growth factor	Homo sapiens	151-154
6092339-6	1984	Mr = 160,000 receptors resulting from swainsonine or monensin treatment were present on the cell surface and retained full function, as judged by 125I-EGF binding to intact cells and detergent-solubilized extracts and by in vitro phosphorylation in the absence or presence of EGF.	Monensin	53-61	epidermal growth factor	Homo sapiens	276-279
6411743-4	1983	This active secretory process can be inhibited by brief exposure of melanoma cells to sodium monensin (10(-7) M), which also results in a modified fibronectin of lower apparent Mr. Monosaccharide-incorporation studies of melanoma fibronectin reveal that monensin significantly inhibits galactose and fucose incorporation into this glycoprotein, correlating with reported effects of monensin on Golgi apparatus functions.	Monensin	86-101	fibronectin 1	Homo sapiens	147-158
6692910-1	1984	Transport of the precursor for carbamoyl-phosphate synthetase I into mitochondria in Reuber hepatoma H-35 cells was inhibited by adding monensin or nigericin to the culture medium at a concentration of 0.5 microM, and the enzyme precursor accumulated, mainly in the cytosolic fraction.	Monensin	136-144	carbamoyl-phosphate synthase 1	Rattus norvegicus	31-63
6433612-8	1984	Prl secretion by 235-1 cells is not affected by dopaminergic agonists and antagonists, TRH, or oestradiol-17 beta but is inhibited in the presence of EGTA or monensin, an ionophore that is believed to act at the level of the Golgi complex.	Monensin	158-166	prolactin	Rattus norvegicus	0-3
6576912-2	1983	NH4Cl and monensin, two agents which neutralize intracellular acidic compartments, block the segregation of iron from transferrin after endocytosis, while neither of these reagents affects internalization of diferric transferrin into the cell.	Monensin	10-18	transferrin	Homo sapiens	118-129
6411743-4	1983	This active secretory process can be inhibited by brief exposure of melanoma cells to sodium monensin (10(-7) M), which also results in a modified fibronectin of lower apparent Mr. Monosaccharide-incorporation studies of melanoma fibronectin reveal that monensin significantly inhibits galactose and fucose incorporation into this glycoprotein, correlating with reported effects of monensin on Golgi apparatus functions.	Monensin	86-101	fibronectin 1	Homo sapiens	230-241
6282896-3	1982	Both the exchange of 5"-nucleotidase between the membranes of cytoplasmic organelles and the cell surface and the internalization of anti-5"-nucleotidase bound to the cell surface were inhibited by approximately 90% in monensin-treated cells.	Monensin	219-227	5' nucleotidase, ecto	Rattus norvegicus	21-36
6282896-3	1982	Both the exchange of 5"-nucleotidase between the membranes of cytoplasmic organelles and the cell surface and the internalization of anti-5"-nucleotidase bound to the cell surface were inhibited by approximately 90% in monensin-treated cells.	Monensin	219-227	5' nucleotidase, ecto	Rattus norvegicus	138-153
33583333-1	2021	The interaction properties of monensin/clopidol with bovine/human serum albumin (BSA/HSA) were determined via multispectral together with molecular modeling techniques in the report.	Monensin	30-38	albumin	Homo sapiens	66-79
7236240-5	1980	The intra- and extra-cellular distribution of newly synthesized beta-hexosaminidase in both monensin-treated normal and I-cell fibroblasts were electrophoretically indistinguishable from the four bands characteristic of I-cell intracellular beta-hexosaminidase.	Monensin	92-100	O-GlcNAcase	Homo sapiens	64-83
7236240-5	1980	The intra- and extra-cellular distribution of newly synthesized beta-hexosaminidase in both monensin-treated normal and I-cell fibroblasts were electrophoretically indistinguishable from the four bands characteristic of I-cell intracellular beta-hexosaminidase.	Monensin	92-100	O-GlcNAcase	Homo sapiens	241-260
33939112-7	2021	RESULTS: We identified Auranofin, Colchicine, Monensin, Niclosamide, Podophyllotoxin, Quinacrine and Thiostrepton as efficient inhibitors of invasive growth of 2nd line HER2 inhibitor lapatinib resistant breast cancer spheroids and ovarian cancer organoids.	Monensin	46-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	169-173
33135724-8	2020	We observed that stimulation of Rab10 and Rab12 phosphorylation induced by agents that stress the endolysosomal system (nigericin, monensin, chloroquine, and LLOMe) was not blocked in Rab29 deficient mouse embryonic fibroblasts.	Monensin	131-139	RAB10, member RAS oncogene family	Mus musculus	32-37
33135724-8	2020	We observed that stimulation of Rab10 and Rab12 phosphorylation induced by agents that stress the endolysosomal system (nigericin, monensin, chloroquine, and LLOMe) was not blocked in Rab29 deficient mouse embryonic fibroblasts.	Monensin	131-139	RAB12, member RAS oncogene family	Mus musculus	42-47
33135724-10	2020	Our findings indicate that basal, pathogenic, as well as nigericin and monensin stimulated LRRK2 pathway activity is not controlled by Rab29.	Monensin	71-79	leucine-rich repeat kinase 2	Mus musculus	91-96
32910713-6	2021	When compared to wild-type CH12 cells, tfg KO CH12 cells were more sensitive towards ER stress induced by tunicamycin, monensin and proteasome inhibition or by expression of an ER-bound immunoglobulin (Ig) mu heavy (microH) chain.	Monensin	119-127	Trk-fused gene	Mus musculus	39-42
32595038-0	2020	Monensin inhibits glioblastoma angiogenesis via targeting multiple growth factor receptor signaling.	Monensin	0-8	receptor-like tyrosine kinase	Mus musculus	67-89
32014461-0	2020	Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells.	Monensin	0-8	MYB proto-oncogene, transcription factor	Homo sapiens	25-28
32736704-6	2020	The addition of monensin effectively suppressed the TGF-beta-induced-EMT conversion, and restored the growth inhibition and the induction of apoptosis by the EGFR-tyrosine kinase inhibitor.	Monensin	16-24	transforming growth factor alpha	Homo sapiens	52-60
32736704-6	2020	The addition of monensin effectively suppressed the TGF-beta-induced-EMT conversion, and restored the growth inhibition and the induction of apoptosis by the EGFR-tyrosine kinase inhibitor.	Monensin	16-24	epidermal growth factor receptor	Homo sapiens	158-162
32310002-3	2020	By contrast, the combination of 40 ppm nicarbazin + 40 ppm monensin provided complete control of infection judged by greater DWG and DFI, and lower FCR.	Monensin	59-67	FCR	Gallus gallus	148-151
32462716-0	2020	Monensin inhibits proliferation, migration, and promotes apoptosis of breast cancer cells via downregulating UBA2.	Monensin	0-8	ubiquitin like modifier activating enzyme 2	Homo sapiens	109-113
32462716-10	2020	We found that Monensin inhibited the proliferation and migration of breast cancer cells and inhibited the expression of MMP-2 and MMP-9.	Monensin	14-22	matrix metallopeptidase 2	Homo sapiens	120-125
32462716-10	2020	We found that Monensin inhibited the proliferation and migration of breast cancer cells and inhibited the expression of MMP-2 and MMP-9.	Monensin	14-22	matrix metallopeptidase 9	Homo sapiens	130-135
32462716-12	2020	Monensin was also found to inhibit UBA2 expression in breast cancer cells.	Monensin	0-8	ubiquitin like modifier activating enzyme 2	Homo sapiens	35-39
32462716-13	2020	Subsequently, after overexpression of UBA2, the impacts of Monensin on proliferation, migration, and apoptosis of breast cancer cells was inhibited.	Monensin	59-67	ubiquitin like modifier activating enzyme 2	Homo sapiens	38-42
32462716-14	2020	In conclusion, Monensin can inhibit the proliferation and migration and activate apoptosis of breast cancer cells via downregulating the expression of UBA2.	Monensin	15-23	ubiquitin like modifier activating enzyme 2	Homo sapiens	151-155
31823108-10	2020	The results of this study represented that the supplementary feeding with propionate precursors, such as monensin and propylene glycol, reduced the insulin resistance in dairy cows during the transition period.	Monensin	105-113	insulin	Bos taurus	148-155
31823108-13	2020	In this regard, to reduce insulin resistance, it is recommended that dairy cows during the transition period be fed with monensin and propylene glycol supplements.	Monensin	121-129	insulin	Bos taurus	26-33
32014461-3	2020	Here, we employed a MYB-reporter cell line and identified the polyether ionophores monensin, salinomycin, and nigericin as novel inhibitors of MYB activity.	Monensin	83-91	MYB proto-oncogene, transcription factor	Homo sapiens	20-23
32014461-3	2020	Here, we employed a MYB-reporter cell line and identified the polyether ionophores monensin, salinomycin, and nigericin as novel inhibitors of MYB activity.	Monensin	83-91	MYB proto-oncogene, transcription factor	Homo sapiens	143-146
32014461-4	2020	As a proof of principle, we show that monensin affects the expression of a significant number of MYB-regulated genes in AML cells and causes down-regulation of MYB expression, loss of cell viability, and induction of differentiation and apoptosis.	Monensin	38-46	MYB proto-oncogene, transcription factor	Homo sapiens	97-100
32014461-4	2020	As a proof of principle, we show that monensin affects the expression of a significant number of MYB-regulated genes in AML cells and causes down-regulation of MYB expression, loss of cell viability, and induction of differentiation and apoptosis.	Monensin	38-46	MYB proto-oncogene, transcription factor	Homo sapiens	160-163
32014461-5	2020	Furthermore, monensin significantly inhibits proliferation of primary murine AML cells but not of normal hematopoietic progenitors, reflecting a high MYB-dependence of leukemic cells and underscoring the efficacy of monensin in MYB-activated malignancies.	Monensin	13-21	myeloblastosis oncogene	Mus musculus	150-153
32014461-5	2020	Furthermore, monensin significantly inhibits proliferation of primary murine AML cells but not of normal hematopoietic progenitors, reflecting a high MYB-dependence of leukemic cells and underscoring the efficacy of monensin in MYB-activated malignancies.	Monensin	13-21	myeloblastosis oncogene	Mus musculus	228-231
32014461-5	2020	Furthermore, monensin significantly inhibits proliferation of primary murine AML cells but not of normal hematopoietic progenitors, reflecting a high MYB-dependence of leukemic cells and underscoring the efficacy of monensin in MYB-activated malignancies.	Monensin	216-224	myeloblastosis oncogene	Mus musculus	228-231
32014461-6	2020	Importantly, monensin also suppressed the viability and non-adherent growth of adenoid cystic carcinoma (ACC) cells expressing MYB-NFIB fusion oncoproteins.	Monensin	13-21	myeloblastosis oncogene	Mus musculus	127-130
32014461-6	2020	Importantly, monensin also suppressed the viability and non-adherent growth of adenoid cystic carcinoma (ACC) cells expressing MYB-NFIB fusion oncoproteins.	Monensin	13-21	nuclear factor I B	Homo sapiens	131-135
32014461-8	2020	Hence, monensin and related compounds are promising molecular scaffolds for development of novel MYB inhibitors.	Monensin	7-15	MYB proto-oncogene, transcription factor	Homo sapiens	97-100
30896968-11	2019	Increased cytoplasmic YAP was observed in monensin-treated SBS fish.	Monensin	42-50	Yes1 associated transcriptional regulator	Danio rerio	22-25
32486191-7	2020	Chloroquine and monensin significantly blocked the uptake of rh-alpha-Gal-A, indicating that the clathrin-mediated endocytosis is involved in recombinant enzyme delivery.	Monensin	16-24	galactosidase alpha	Homo sapiens	64-75
31870162-4	2020	RESULTS: Golgi stressors (brefeldin A and monensin) decreased the expressions of GM130 and ATP2C1 (two markers of Golgi stress response), induced Golgi apparatus fragmentation, and caused higher level of oxidative stress and cell apoptosis in mouse myoblast cells.	Monensin	42-50	golgi autoantigen, golgin subfamily a, 2	Mus musculus	81-86
31870162-4	2020	RESULTS: Golgi stressors (brefeldin A and monensin) decreased the expressions of GM130 and ATP2C1 (two markers of Golgi stress response), induced Golgi apparatus fragmentation, and caused higher level of oxidative stress and cell apoptosis in mouse myoblast cells.	Monensin	42-50	ATPase, Ca++-sequestering	Mus musculus	91-97
31591384-4	2019	ICF-induced osterix (OSX) expression was inhibited by cycloheximide and monensin.	Monensin	72-80	Sp7 transcription factor	Homo sapiens	12-19
29317536-8	2018	Accordingly, we harnessed the monensin-ATF4-signaling cascade to stimulate CSE expression by preconditioning cells with monensin, which restores cysteine metabolism and an optimal stress response in HD.	Monensin	120-128	cystathionine gamma-lyase	Homo sapiens	75-78
29777253-4	2018	In line with previous reports, the Glow-AGT assay showed that mitochondrial transport inhibitors DECA and monensin increased peroxisomal localization of the mutant.	Monensin	106-114	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	40-43
29455434-3	2018	Interestingly, treatment of Neuro2a cells expressing Flag-tagged full-length CREB3 with monensin and nigericin induced the expression of the approximately 50 kDa N-terminal fragment; however, its cleavage was not parallel to the levels of GADD153 and LC3-II.	Monensin	88-96	cAMP responsive element binding protein 3	Mus musculus	77-82
29455434-3	2018	Interestingly, treatment of Neuro2a cells expressing Flag-tagged full-length CREB3 with monensin and nigericin induced the expression of the approximately 50 kDa N-terminal fragment; however, its cleavage was not parallel to the levels of GADD153 and LC3-II.	Monensin	88-96	DNA-damage inducible transcript 3	Mus musculus	239-246
29317536-8	2018	Accordingly, we harnessed the monensin-ATF4-signaling cascade to stimulate CSE expression by preconditioning cells with monensin, which restores cysteine metabolism and an optimal stress response in HD.	Monensin	30-38	activating transcription factor 4	Homo sapiens	39-43
27793906-7	2016	In addition, monensin induced the production of ROS and the disruption of Ca2+ homeostasis, that was restored by diphenyleneiodonium, a mitochondrial ROS inhibitor and verapamil, a Ca2+ channel blocker, respectively, as confirmed by pro-caspase-3 activation and poly ADP ribose polymerase cleavage.	Monensin	13-21	caspase 3	Homo sapiens	233-246
29317536-8	2018	Accordingly, we harnessed the monensin-ATF4-signaling cascade to stimulate CSE expression by preconditioning cells with monensin, which restores cysteine metabolism and an optimal stress response in HD.	Monensin	30-38	cystathionine gamma-lyase	Homo sapiens	75-78
29317536-8	2018	Accordingly, we harnessed the monensin-ATF4-signaling cascade to stimulate CSE expression by preconditioning cells with monensin, which restores cysteine metabolism and an optimal stress response in HD.	Monensin	120-128	activating transcription factor 4	Homo sapiens	39-43
27793906-7	2016	In addition, monensin induced the production of ROS and the disruption of Ca2+ homeostasis, that was restored by diphenyleneiodonium, a mitochondrial ROS inhibitor and verapamil, a Ca2+ channel blocker, respectively, as confirmed by pro-caspase-3 activation and poly ADP ribose polymerase cleavage.	Monensin	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	262-288
25181483-7	2014	The inhibition of lysosomal function by monensin or bafilomycin A1 after the occurrence of PrP(Sc) redistribution by CPZ or U18666A partly antagonized PrP(Sc) degradation, suggesting that the transfer of PrP(Sc) to late endosomes/lysosomes, possibly via alteration of the membrane trafficking machinery of cells, leads to PrP(Sc) degradation.	Monensin	40-48	prion protein	Mus musculus	91-94
27060485-9	2016	Double exposures to 1-OH-PGE1 induced a greater increase in calcitonin gene-related peptide (CGRP) release than a single exposure or vehicle exposure, an event blocked by pre-treatment with the recycling inhibitor monensin.	Monensin	214-222	calcitonin related polypeptide alpha	Homo sapiens	60-91
27060485-9	2016	Double exposures to 1-OH-PGE1 induced a greater increase in calcitonin gene-related peptide (CGRP) release than a single exposure or vehicle exposure, an event blocked by pre-treatment with the recycling inhibitor monensin.	Monensin	214-222	calcitonin related polypeptide alpha	Homo sapiens	93-97
27127411-4	2016	In addition, monensin was approved as an antibiotic to be fed in dairy cattle, and it was reported that dairy cows supplemented with monensin produced milk containing higher concentration of 18:1 t10 and 18:1 t11.	Monensin	13-21	Weaning weight-maternal milk	Bos taurus	151-155
27127411-4	2016	In addition, monensin was approved as an antibiotic to be fed in dairy cattle, and it was reported that dairy cows supplemented with monensin produced milk containing higher concentration of 18:1 t10 and 18:1 t11.	Monensin	133-141	Weaning weight-maternal milk	Bos taurus	151-155
25181483-7	2014	The inhibition of lysosomal function by monensin or bafilomycin A1 after the occurrence of PrP(Sc) redistribution by CPZ or U18666A partly antagonized PrP(Sc) degradation, suggesting that the transfer of PrP(Sc) to late endosomes/lysosomes, possibly via alteration of the membrane trafficking machinery of cells, leads to PrP(Sc) degradation.	Monensin	40-48	prion protein	Mus musculus	151-154
25181483-7	2014	The inhibition of lysosomal function by monensin or bafilomycin A1 after the occurrence of PrP(Sc) redistribution by CPZ or U18666A partly antagonized PrP(Sc) degradation, suggesting that the transfer of PrP(Sc) to late endosomes/lysosomes, possibly via alteration of the membrane trafficking machinery of cells, leads to PrP(Sc) degradation.	Monensin	40-48	prion protein	Mus musculus	151-154
25181483-7	2014	The inhibition of lysosomal function by monensin or bafilomycin A1 after the occurrence of PrP(Sc) redistribution by CPZ or U18666A partly antagonized PrP(Sc) degradation, suggesting that the transfer of PrP(Sc) to late endosomes/lysosomes, possibly via alteration of the membrane trafficking machinery of cells, leads to PrP(Sc) degradation.	Monensin	40-48	prion protein	Mus musculus	151-154
23769353-11	2013	When analyzed across dairy and beef cattle studies, DMI or monensin dose (mg/kg of DMI) tended to decrease or increase the effect of monensin in reducing methane emissions, respectively.	Monensin	59-67	DMI	Bos taurus	83-86
25568713-6	2014	Significant increase of creatine kinase, lactate dehydrogenase, aspartate aminotransferase, total bilirubin, blood urea nitrogen, creatinine and erythrocyte superoxide dismutase were observed in monensin exposed goats.	Monensin	195-203	lactate dehydrogenase	Capra hircus	41-62
25568713-6	2014	Significant increase of creatine kinase, lactate dehydrogenase, aspartate aminotransferase, total bilirubin, blood urea nitrogen, creatinine and erythrocyte superoxide dismutase were observed in monensin exposed goats.	Monensin	195-203	aspartate aminotransferase, cytoplasmic	Capra hircus	64-90
23769353-11	2013	When analyzed across dairy and beef cattle studies, DMI or monensin dose (mg/kg of DMI) tended to decrease or increase the effect of monensin in reducing methane emissions, respectively.	Monensin	133-141	DMI	Bos taurus	52-55
23769353-11	2013	When analyzed across dairy and beef cattle studies, DMI or monensin dose (mg/kg of DMI) tended to decrease or increase the effect of monensin in reducing methane emissions, respectively.	Monensin	133-141	DMI	Bos taurus	83-86
21073417-4	2010	Using Na+/K+ ionophores (monensin, nigericin) and media with different content of monovalent cations, we revealed that p38 MAPK phosphorylation in ouabain-treated renal epithelial cells is not caused by Na,K-ATPase inhibition and inversion of the [Na+](i)/[K+](i) ratio.	Monensin	25-33	mitogen-activated protein kinase 14	Homo sapiens	119-122
21062307-5	2010	Monensin, salinomycin and maduramycin had no effect on caffeine metabolism, protein expression and mRNA expression, but did induce dapsone metabolism, increasing CYP3A protein expression.	Monensin	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	162-167
23601315-1	2013	We examined the response of Na(+),K(+)-ATPase (NKA) to monensin, a Na(+) ionophore, with and without ouabain, an NKA inhibitor, in suspensions of human erythrocytes (red blood cells).	Monensin	55-63	tachykinin precursor 1	Homo sapiens	28-45
23601315-1	2013	We examined the response of Na(+),K(+)-ATPase (NKA) to monensin, a Na(+) ionophore, with and without ouabain, an NKA inhibitor, in suspensions of human erythrocytes (red blood cells).	Monensin	55-63	tachykinin precursor 1	Homo sapiens	47-50
22169219-8	2012	Furthermore, leupeptin enhanced the cell surface localization of FGFR1 by increased receptor recycling and this effect was abolished by the recycling inhibitor monensin.	Monensin	160-168	Fibroblast growth factor receptor 1	Rattus norvegicus	65-70
23284781-7	2012	Treatment of cells with monensin to disrupt Golgi-mediated granule secretion decreased SMN expression in neurites and caused growth cone defects similar to those seen in SMN knockdown cells.	Monensin	24-32	survival motor neuron 1	Mus musculus	87-90
16720603-9	2006	A secretory component which is sensitive to monensin and N-ethylmaleimide and insensitive to brefeldin A may also be necessary for the release and provision of substrates for peroxidase-dependent generation of H(2)O(2).	Monensin	44-52	peroxidase	Arabidopsis thaliana	175-185
20472302-7	2010	BDNF 100ng/mL pretreatment or co-treatment attenuated the monensin-induced apoptosis.	Monensin	58-66	brain derived neurotrophic factor	Homo sapiens	0-4
20418542-6	2010	Finally, chemical disruption of the lysosomal function by feeding animals with antimalarial drugs, chloroquine or monensin, leads to malignant tumor growth of the Ras(V12) cells.	Monensin	114-122	Ras oncogene at 85D	Drosophila melanogaster	163-170
19407085-0	2009	Clinical findings and serum cardiac troponin I concentrations in horses after intragastric administration of sodium monensin.	Monensin	109-124	troponin I3, cardiac type	Equus caballus	28-46
18973588-11	2008	Furthermore, the Na(+)/K(+)-ATPase inhibitor, ouabain, and the Na(+) ionophores, gramicidin and monensin, produced GLT-1 clustering.	Monensin	96-104	solute carrier family 1 member 2	Rattus norvegicus	115-120
18758509-5	2008	Brefeldin A, bafilomycin A1, ammonium chloride, and monensin also prevented pro-TGFbeta processing.	Monensin	52-60	transforming growth factor beta 1	Homo sapiens	80-87
18256049-9	2008	Absence of DRP1A reduces endocytotic uptake of FM4-64 into the cytoplasm of root cells and the hypersensitivity of elongation and radial swelling in rsw9 to the trafficking inhibitor monensin suggests that impaired endocytosis may contribute to the development of shorter fatter roots, probably by reducing cellulose synthesis.	Monensin	183-191	dynamin-like protein	Arabidopsis thaliana	11-16
19768636-1	2010	Alkaline-earth metal complexes of the monoanionic form of the polyether ionophore monensin A were isolated for the first time in solid state and were structurally characterized using various spectroscopic methods (IR, NMR, FAB-MS).	Monensin	82-92	FA complementation group B	Homo sapiens	223-226
19656284-3	2009	HYPOTHESIS: Serum cTnI correlates to myocardial function and histopathologic lesions in cattle with monensin-induced myocardial injury.	Monensin	100-108	troponin I3, cardiac type	Homo sapiens	18-22
19211916-5	2009	Microtubule disrupting agents disrupted the mobility of trafficking vesicles and impaired cell surface delivery of hSMVT, which was also prevented in cells treated with dynamitin (p50), brefeldin, or monensin.	Monensin	200-208	solute carrier family 5 member 6	Homo sapiens	115-120
19164691-1	2009	This field trial evaluated the effects of dietary supplementation with 16 mg/kg (based on total dry matter intake) of monensin sodium on bulk tank milk fat percentage (MFP) of commercial dairy herds.	Monensin	118-133	FP	Bos taurus	147-166
19164691-1	2009	This field trial evaluated the effects of dietary supplementation with 16 mg/kg (based on total dry matter intake) of monensin sodium on bulk tank milk fat percentage (MFP) of commercial dairy herds.	Monensin	118-133	FP	Bos taurus	168-171
16514055-6	2006	ATP-induced MMP-9 release was inhibited by the P2X(7) receptor antagonists periodate oxidized ATP and KN-62, or by calcium chelators, as well as by a loss-of-function polymorphism in the P2X(7) receptor, but not by brefeldin A, monensin, or cycloheximide, or by anti-tumor necrosis factor-alpha (TNF-alpha) or anti-interleukin-1beta (IL-1beta) monoclonal antibodies.	Monensin	228-236	matrix metallopeptidase 9	Homo sapiens	12-17
16514055-6	2006	ATP-induced MMP-9 release was inhibited by the P2X(7) receptor antagonists periodate oxidized ATP and KN-62, or by calcium chelators, as well as by a loss-of-function polymorphism in the P2X(7) receptor, but not by brefeldin A, monensin, or cycloheximide, or by anti-tumor necrosis factor-alpha (TNF-alpha) or anti-interleukin-1beta (IL-1beta) monoclonal antibodies.	Monensin	228-236	purinergic receptor P2X 7	Homo sapiens	187-202
16204649-8	2005	Coprecipitation of CXCR4 with CD4 was reduced in activated cells treated with Brefeldin A and Monensin, suggesting that late endosomes play a role in intracellular association of CXCR4 with CD4.	Monensin	94-102	C-X-C motif chemokine receptor 4	Homo sapiens	19-24
16204649-8	2005	Coprecipitation of CXCR4 with CD4 was reduced in activated cells treated with Brefeldin A and Monensin, suggesting that late endosomes play a role in intracellular association of CXCR4 with CD4.	Monensin	94-102	CD4 molecule	Homo sapiens	30-33
16204649-8	2005	Coprecipitation of CXCR4 with CD4 was reduced in activated cells treated with Brefeldin A and Monensin, suggesting that late endosomes play a role in intracellular association of CXCR4 with CD4.	Monensin	94-102	C-X-C motif chemokine receptor 4	Homo sapiens	179-184
16204649-8	2005	Coprecipitation of CXCR4 with CD4 was reduced in activated cells treated with Brefeldin A and Monensin, suggesting that late endosomes play a role in intracellular association of CXCR4 with CD4.	Monensin	94-102	CD4 molecule	Homo sapiens	190-193
15729714-5	2005	On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells.	Monensin	19-27	solute carrier family 9 member C1	Homo sapiens	58-61
15729714-5	2005	On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells.	Monensin	19-27	solute carrier family 9 member C1	Homo sapiens	134-137
15707965-2	2005	We found that ionophore monensin (Mon) and the quaternary amine chloroquine (CQ) discriminate between the traffic routes of TRP-2 and TRP-1.	Monensin	24-32	tRNA proline 2	Mus musculus	124-129
15729714-5	2005	On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells.	Monensin	19-27	glucose-6-phosphate isomerase	Homo sapiens	167-170
15855253-4	2005	Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm).	Monensin	236-244	interferon gamma	Homo sapiens	28-36
15499571-7	2005	Finally, studies using cycloheximide and monensin showed that upon stimulation with GHRH, an optimal concentration of functional GHRH-R was maintained at the plasma membrane due to de novo synthesis and recycling in pituitary cells and to de novo synthesis solely in hGHRH-R-transfected BHK cells.	Monensin	41-49	somatoliberin	Mesocricetus auratus	84-88
15499571-7	2005	Finally, studies using cycloheximide and monensin showed that upon stimulation with GHRH, an optimal concentration of functional GHRH-R was maintained at the plasma membrane due to de novo synthesis and recycling in pituitary cells and to de novo synthesis solely in hGHRH-R-transfected BHK cells.	Monensin	41-49	growth hormone releasing hormone receptor	Rattus norvegicus	129-135
15707965-2	2005	We found that ionophore monensin (Mon) and the quaternary amine chloroquine (CQ) discriminate between the traffic routes of TRP-2 and TRP-1.	Monensin	24-32	tyrosinase-related protein 1	Mus musculus	134-139
15210689-4	2004	Detailed analysis of CB1-EGFP expressed in HEK-293 cells shows that the intracellular CB1R population is mostly of endocytic origin and that treatment with inverse agonist AM281 traps CB1R at the plasma membrane through a monensin-sensitive recycling pathway.	Monensin	222-230	cannabinoid receptor 1	Homo sapiens	21-24
15474457-6	2004	Hsp70 release was inhibited by monensin, methyl-beta-cyclodextrin, and methylamine, but not by brefeldin A.	Monensin	31-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
15210689-4	2004	Detailed analysis of CB1-EGFP expressed in HEK-293 cells shows that the intracellular CB1R population is mostly of endocytic origin and that treatment with inverse agonist AM281 traps CB1R at the plasma membrane through a monensin-sensitive recycling pathway.	Monensin	222-230	cannabinoid receptor 1	Homo sapiens	184-188
12502869-10	2003	In contrast, presentation of the Nef lipopeptide was not inhibited by epoxomycin but was inhibited by monensin, a classical inhibitor of acid-dependent endosomal enzyme activity, indicating an endocytic processing pathway yielding to major histocompatibility complex class I-restricted presentation.	Monensin	102-110	S100 calcium binding protein B	Homo sapiens	33-36
14736881-5	2004	NCX1 immunoreactivity was detectable in HEK293 as well as in TRPC3-overexpressing HEK293 cells, and reduction of extracellular Na(+) after Na(+) loading with monensin resulted in significant rises in intracellular free Ca(2+) (Ca(2+)(i)) of HEK293 cells.	Monensin	158-166	solute carrier family 8 member A1	Homo sapiens	0-4
12746290-3	2003	Both Ca(2+) and Na(+) ionophores (A23187 and monensin) stimulated phosphorylation of CAKbeta in a similar fashion to mechanical stretch.	Monensin	45-53	protein tyrosine kinase 2 beta	Rattus norvegicus	85-92
12607930-3	2002	We found that the antibiotics chlorotetracycline, doxycycline, monensin, the synthetic antimicrobial pyrimethamine and the steroid hormone testosterone inhibited beta-hexosaminidase release.	Monensin	63-71	O-GlcNAcase	Rattus norvegicus	162-181
12117412-4	2002	Recombinant uPA induced the release of MMP9/gelatinase B, as detected by zymography and Western blotting, and this release was abolished by actinomycin D and cycloheximide (inhibitors of DNA transcription and protein synthesis) and partially suppressed by monensin (an inhibitor of secretion).	Monensin	256-264	plasminogen activator, urokinase	Homo sapiens	12-15
12117412-4	2002	Recombinant uPA induced the release of MMP9/gelatinase B, as detected by zymography and Western blotting, and this release was abolished by actinomycin D and cycloheximide (inhibitors of DNA transcription and protein synthesis) and partially suppressed by monensin (an inhibitor of secretion).	Monensin	256-264	matrix metallopeptidase 9	Homo sapiens	39-43
11449408-6	2001	The percentage of IL-6 and TNF-alpha-producing monocytes after 8 h of culture without stimulation revealed significant lower values for monensin-treated than for brefeldin A-treated monocytes.	Monensin	136-144	interleukin 6	Homo sapiens	18-22
11349133-4	2001	Studies of the localization and trafficking of ABCA1-GFP in the presence of brefeldin A or monensin, agents known to block intracellular vesicular trafficking, as well as apoA-I-mediated cellular lipid efflux, showed that: (i) ABCA1 functions in lipid efflux at the cell surface, and (ii) delivery of ABCA1 to lysosomes for degradation may serve as a mechanism to modulate its surface expression.	Monensin	91-99	ATP binding cassette subfamily A member 1	Homo sapiens	47-52
11349133-4	2001	Studies of the localization and trafficking of ABCA1-GFP in the presence of brefeldin A or monensin, agents known to block intracellular vesicular trafficking, as well as apoA-I-mediated cellular lipid efflux, showed that: (i) ABCA1 functions in lipid efflux at the cell surface, and (ii) delivery of ABCA1 to lysosomes for degradation may serve as a mechanism to modulate its surface expression.	Monensin	91-99	ATP binding cassette subfamily A member 1	Homo sapiens	227-232
11349133-4	2001	Studies of the localization and trafficking of ABCA1-GFP in the presence of brefeldin A or monensin, agents known to block intracellular vesicular trafficking, as well as apoA-I-mediated cellular lipid efflux, showed that: (i) ABCA1 functions in lipid efflux at the cell surface, and (ii) delivery of ABCA1 to lysosomes for degradation may serve as a mechanism to modulate its surface expression.	Monensin	91-99	ATP binding cassette subfamily A member 1	Homo sapiens	227-232
11920574-3	2002	TSP-1 in T lymphocytes has a high turnover as shown by the fact that brefeldin and monensin rapidly increase while cycloheximide tend to decrease the cellular TSP-1 content.	Monensin	83-91	thrombospondin 1	Homo sapiens	0-5
11449408-6	2001	The percentage of IL-6 and TNF-alpha-producing monocytes after 8 h of culture without stimulation revealed significant lower values for monensin-treated than for brefeldin A-treated monocytes.	Monensin	136-144	tumor necrosis factor	Homo sapiens	27-36
11449408-8	2001	The spontaneous intracellular production in molecules of equivalent soluble fluorochrome units (MESF) of IL-1beta, IL-6, and TNF-alpha after 8 h of culture was higher in brefeldin A than in monensin-inhibited monocytes.	Monensin	190-198	interleukin 1 beta	Homo sapiens	105-113
11449408-8	2001	The spontaneous intracellular production in molecules of equivalent soluble fluorochrome units (MESF) of IL-1beta, IL-6, and TNF-alpha after 8 h of culture was higher in brefeldin A than in monensin-inhibited monocytes.	Monensin	190-198	tumor necrosis factor	Homo sapiens	125-134
11444150-1	2001	Previously, we demonstrated that beta 1,4galactosyltransferase (gal-T1) reversibly segregates from alpha 2,6sialyltransferase (ST6Gal) to swollen vesicles after monensin treatment of the cells.	Monensin	161-169	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	99-125
11444150-1	2001	Previously, we demonstrated that beta 1,4galactosyltransferase (gal-T1) reversibly segregates from alpha 2,6sialyltransferase (ST6Gal) to swollen vesicles after monensin treatment of the cells.	Monensin	161-169	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	127-133
11139343-5	2001	Treatment of Caucasian melanocytes with the lysosomotropic compound ammonium chloride or with the ionophores nigericin and monensin results in a rapid and pronounced increase in tyrosinase activity.	Monensin	123-131	tyrosinase	Homo sapiens	178-188
10820580-2	2000	The results indicate that the combination of monensin + sulfadimethoxine gave a short-term inhibition of microsomal cytochrome P-450 monooxygenase activity but apparently did not influence the metabolism of other (exogenic) substances (ketamine, xylazine), and did not change the state of antioxidant systems or the relative liver weight.	Monensin	45-53	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	116-146
10956649-7	2000	BACE and furin co-localize within the Golgi apparatus, and propeptide cleavage is inhibited by brefeldin A and monensin, drugs that disrupt trafficking through the Golgi.	Monensin	111-119	beta-secretase 1	Homo sapiens	0-4
10956649-7	2000	BACE and furin co-localize within the Golgi apparatus, and propeptide cleavage is inhibited by brefeldin A and monensin, drugs that disrupt trafficking through the Golgi.	Monensin	111-119	furin, paired basic amino acid cleaving enzyme	Homo sapiens	9-14
10884369-7	2000	Chloroquine and monensin, compounds that disrupt plasma membrane recycling, reduced hH1 current, suggesting rapid turnover of channels at the cell surface.	Monensin	16-24	H1.5 linker histone, cluster member	Homo sapiens	84-87
10734075-3	2000	Carbonyl cyanide m-chlorophenyl hydrazone (CCCP), castanospermine, monensin, and colchicin all inhibited secretion of HL without affecting its specific enzyme activity.	Monensin	67-75	lipase C, hepatic type	Rattus norvegicus	118-120
10734075-4	2000	The specific enzyme activity of intracellular HL was decreased by 25-50% upon incubation with CCCP or castanospermine, and increased 2-fold with monensin and colchicin.	Monensin	145-153	lipase C, hepatic type	Rattus norvegicus	46-48
10632603-3	2000	NT-3 immunolabel in these tectal layers is largely reduced or abolished after treatment of the eye with colchicine or monensin, demonstrating that endogenous NT-3 is transported to the optic tectum by retinal ganglion cells (RGCs).	Monensin	118-126	neurotrophin 3	Gallus gallus	0-4
10632603-3	2000	NT-3 immunolabel in these tectal layers is largely reduced or abolished after treatment of the eye with colchicine or monensin, demonstrating that endogenous NT-3 is transported to the optic tectum by retinal ganglion cells (RGCs).	Monensin	118-126	neurotrophin 3	Gallus gallus	158-162
9784619-11	1998	While treatment with monensin or concanavalin A result only in an increase of the putative activator MT1-MMP, orthovanadate also reduces the production of the specific inhibitor TIMP-2.	Monensin	21-29	matrix metallopeptidase 14	Homo sapiens	101-108
10572242-4	1999	Internalization of (125)I-Ang IV was considerably decreased after pretreatment of cells with hyperosmolar sucrose or after pretreatment of BAEC with inhibitors of endosomal acidification such as monensin or NH(4)Cl.	Monensin	195-203	ANG	Bos taurus	26-29
10443458-4	1999	In contrast, when pHi was increased by simultaneous addition of NH4Cl, methylamine or monensin, aggregation in response to a low concentration of thrombin, U46619, arachidonic acid or A23187 was enhanced significantly.	Monensin	86-94	glucose-6-phosphate isomerase	Oryctolagus cuniculus	18-21
10443458-4	1999	In contrast, when pHi was increased by simultaneous addition of NH4Cl, methylamine or monensin, aggregation in response to a low concentration of thrombin, U46619, arachidonic acid or A23187 was enhanced significantly.	Monensin	86-94	prothrombin	Oryctolagus cuniculus	146-154
10025898-20	1999	We conclude that monensin, nigericin and the combination of NH4Cl and chloroquine can be used instead of NH4Cl to potentiate CD22-rec ricin A activity in purging autologous bone marrow transplants contaminated with malignant B cells.	Monensin	17-25	CD22 molecule	Homo sapiens	125-129
9795009-6	1998	From the lysosomotropic reagents study, both ammonium chloride and monensin suppressed transcytosis and recycling as well as the degradation of EGF, while both chloroquine and bafilomycin A selectively suppressed the degradation process with only a minimal effect on transcytosis, resulting in an increase in the amount transcytosed.	Monensin	67-75	epidermal growth factor	Canis lupus familiaris	144-147
10540182-8	1999	LS-180 cells spontaneously released hTM5 as well as CEP into the culture medium that was significantly stimulated by a calcium ionophore, A23187, but inhibited by phorbol-12-myristate-13-acetate, monensin and methylamine.	Monensin	196-204	tropomyosin 3	Homo sapiens	36-40
10471978-6	1999	Finally, mitogen-induced cytoplasmic IL-2 accumulation was enhanced by stimulation in the presence of monensin but not the Pgp functional inhibitor verapamil.	Monensin	102-110	interleukin 2	Homo sapiens	37-41
9784619-11	1998	While treatment with monensin or concanavalin A result only in an increase of the putative activator MT1-MMP, orthovanadate also reduces the production of the specific inhibitor TIMP-2.	Monensin	21-29	TIMP metallopeptidase inhibitor 2	Homo sapiens	178-184
9738664-5	1998	Inhibitors of endosomal acidification (bafilomycin A, monensin) inhibited LPS-stimulated TNF-alpha release by 92 +/- 11% (P < 0.001 when no inhibitor was used) when added 10 min after LPS and their effect was totally abrogated when added 45 min after LPS.	Monensin	54-62	tumor necrosis factor	Rattus norvegicus	89-98
9751187-5	1998	In addition, the intracellular generation of these A beta42 species in wt and mutated PS1-induced cells was completely blocked by brefeldin A, whereas it exhibited differential sensitivities to monensin: the increased accumulation of intracellular A beta x-42 versus inhibition of intracellular A beta1-42 generation.	Monensin	194-202	amyloid beta precursor protein	Homo sapiens	51-57
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	Monensin	197-205	uncoupling protein 1	Homo sapiens	122-126
9278099-8	1997	Chloroquine (100 microM) inhibited the [3H]Ang II dissociation from cells, and monensin (25 microM) induced a 30% inhibition of [3H]Ang II binding (35 degrees, 3 hr), suggesting endosomal processing of the Ang II-receptor complex with receptor recycling to the cell surface.	Monensin	79-87	angiotensinogen	Rattus norvegicus	132-138
9361682-3	1997	Accordingly, to further investigate the mechanisms of the derangements observed in NIDDM cells, we examined the effects of the ionophore monensin, which inhibits endosomal acidification, on the cellular processing of insulin and insulin receptor in monocytes from control subjects (n = 12) and NIDDM patients (n = 14).	Monensin	137-145	insulin	Homo sapiens	217-224
9361682-3	1997	Accordingly, to further investigate the mechanisms of the derangements observed in NIDDM cells, we examined the effects of the ionophore monensin, which inhibits endosomal acidification, on the cellular processing of insulin and insulin receptor in monocytes from control subjects (n = 12) and NIDDM patients (n = 14).	Monensin	137-145	insulin receptor	Homo sapiens	229-245
9361682-8	1997	High-performance liquid chromatography (HPLC) analysis of intracellular radioactivity showed that after monensin intracellular intact insulin significantly increased (P < .01), thus suggesting a decrease of intracellular insulin degradation.	Monensin	104-112	insulin	Homo sapiens	134-141
9312089-6	1997	When the purified ATPase was reconstituted into liposomes prepared from Enterococcus faecalis phospholipids, ATP-driven Na+ uptake was observed; uptake was blocked by nitrate, destruxin B, and monensin, but it accelerated by carbonyl cyanide m-chlorophenylhydrazone and valinomycin.	Monensin	193-201	ATPase	Enterococcus faecalis	18-24
9350283-0	1997	Interferon-gamma enhancement of E-selectin expression on endothelial cells is inhibited by monensin.	Monensin	91-99	interferon gamma	Homo sapiens	0-16
9350283-0	1997	Interferon-gamma enhancement of E-selectin expression on endothelial cells is inhibited by monensin.	Monensin	91-99	selectin E	Homo sapiens	32-42
9278099-8	1997	Chloroquine (100 microM) inhibited the [3H]Ang II dissociation from cells, and monensin (25 microM) induced a 30% inhibition of [3H]Ang II binding (35 degrees, 3 hr), suggesting endosomal processing of the Ang II-receptor complex with receptor recycling to the cell surface.	Monensin	79-87	angiotensinogen	Rattus norvegicus	132-138
8940040-11	1996	Brefeldin A and monensin, inhibitors of protein processing through the Golgi, both blocked the 8-Br-cAMP stimulation of cholesterol efflux to exogenous apoE.	Monensin	16-24	apolipoprotein E	Homo sapiens	152-156
9473774-4	1997	Nonrestricted CD45 epitopes were not affected by the sialyl acid cleavage with sodium metaperiodate or neuraminidase, but were sensitive to both, tunicamycin, the N-glycosylation inhibitor and monensin, an inhibitor of protein transport through the Golgi compartment.	Monensin	193-201	protein tyrosine phosphatase receptor type C	Homo sapiens	14-18
9246941-8	1997	The inhibition of insulin-stimulated 2-deoxyglucose uptake by monensin was associated with a 31% decrease in the abundance of insulin receptors in muscles, a 64% decrease in the insulin-induced autophosphorylation of the insulin receptor beta-subunit, and a 44% reduction of the insulin-stimulated phosphatidylinositol 3-kinase activity.	Monensin	62-70	insulin receptor	Rattus norvegicus	126-142
9211989-5	1997	A diffuse extracellular Tn immunoreactivity and a distinct cytoplasmic reaction were seen in differentiated cells especially after exposure to monensin to inhibit cellular secretion.	Monensin	143-151	tenascin C	Homo sapiens	24-26
9017504-5	1996	Inhibition of cholesterol efflux by these agents could not be overcome by increasing the apoA-I concentration and persisted during incubations up to 24 h. Similarly, brefeldin A and monensin inhibited up to 80% of apoA-I-mediated efflux of labeled phospholipids from cholesterol-loaded cells relative to controls.	Monensin	182-190	apolipoprotein A1	Homo sapiens	214-220
8756575-3	1996	Incubation for 20 h with the lysosomotropic agents NH4Cl and monensin inhibited GH internalization and reduced cell surface GHR, whereas no significant effect on the level of secreted GHBP was observed.	Monensin	61-69	growth hormone receptor	Oryctolagus cuniculus	124-127
8944708-4	1996	Bafilomycin A, monensin, and chloroquine, which prevent endosomal acidification, also blocked LPS-stimulated release of TNF-alpha by > 90%.	Monensin	15-23	tumor necrosis factor	Rattus norvegicus	120-129
8897874-3	1996	Release of VIP was stimulated by depolarization with KCl (65 mM, 143%) and in the presence of veratridine (10(-6) M, 184%), monensin (10(-5) M, 131%), and the Ca2+ ionophore A-23187 (10(-6) M, 160%).	Monensin	124-132	vasoactive intestinal peptide	Rattus norvegicus	11-14
8756575-10	1996	NH4Cl and monensin reduced GHR restoration by about 50%, but the recovery of GHBP was not affected.	Monensin	10-18	growth hormone receptor	Oryctolagus cuniculus	27-30
7494251-14	1995	In conclusion, monensin and nigericin are potent inhibitors of poliovirus genome replication that prevent the shutoff of host translation by poliovirus while still permitting cleavage of p220.	Monensin	15-23	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	187-191
8678901-2	1996	The cell-killing potency of RTA-IT can be drastically increased in vitro by using ionophores such as monensin.	Monensin	101-109	MAS related GPR family member F	Homo sapiens	28-31
8061052-8	1994	Cycloheximide also inhibited FN release, but this inhibition was additive to that with monensin.	Monensin	87-95	fibronectin 1	Homo sapiens	29-31
7626659-9	1995	Both normal fibronectin and fibronectin in which canavanine replaced arginine were stable for 20 h in cells treated with brefeldin A or monensin.	Monensin	136-144	fibronectin 1	Homo sapiens	28-39
7608173-10	1995	Pretreatment with monensin, sodium azide, or colchicine reduced surface binding of 125I-ASOR in HuH-7 cells by 50% but had no effect on binding to Trf1 cells.	Monensin	18-26	MIR7-3 host gene	Homo sapiens	96-101
7768511-6	1995	Both the appearance of intracellular cMOAT and the disappearance of transport activity from the plasma membrane were completely inhibited at temperatures below 20 degrees C. Residual cMOAT activity in 24-hour cultured hepatocytes could be further diminished by incubation of the cells with 1 mumol/L monensin or 10 mmol/L methylamine.	Monensin	300-308	ATP binding cassette subfamily C member 2	Rattus norvegicus	37-42
7768511-6	1995	Both the appearance of intracellular cMOAT and the disappearance of transport activity from the plasma membrane were completely inhibited at temperatures below 20 degrees C. Residual cMOAT activity in 24-hour cultured hepatocytes could be further diminished by incubation of the cells with 1 mumol/L monensin or 10 mmol/L methylamine.	Monensin	300-308	ATP binding cassette subfamily C member 2	Rattus norvegicus	183-188
18476229-8	1994	We here report that mobile ionophores such as valinomycin, nonactin, nigericin, monensin, calcimycin, lasalocid inhibit the efflux of anthracycline by P-glycoprotein whereas, channel-forming ionophores such as gramicidin do not.	Monensin	80-88	ATP binding cassette subfamily B member 1	Homo sapiens	151-165
8089706-2	1994	Under conditions which block the addition of opsin to outer segments, various lipids continue to be synthesized and transported to the outer segment in the presence of monensin, puromycin, brefeldin A, tunicamycin and several general metabolic inhibitors.	Monensin	168-176	rhodopsin, gene2 L homeolog	Xenopus laevis	45-50
7910172-5	1994	Processing of urushiol for presentation to CD8+ T cells was inhibited by azide, monensin, and brefeldin A.	Monensin	80-88	CD8a molecule	Homo sapiens	43-46
8392648-8	1993	Monensin but not cycloheximide inhibited RGDS restoration of CD16 and CD32w.	Monensin	0-8	ral guanine nucleotide dissociation stimulator	Homo sapiens	41-45
8262250-2	1993	Monensin and brefeldin A inhibited the two proteolytic cleavages of the precursor indicating that they are post-Golgi events as previously reported for the unique cleavage of LPH in man.	Monensin	0-8	lactase	Homo sapiens	175-178
8283140-0	1994	Processing and intracellular transport of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937-modulation by brefeldin A, ammonium chloride, and monensin.	Monensin	168-176	cathepsin G	Homo sapiens	42-53
8283140-0	1994	Processing and intracellular transport of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937-modulation by brefeldin A, ammonium chloride, and monensin.	Monensin	168-176	elastase, neutrophil expressed	Homo sapiens	58-77
8410828-5	1993	Immunolocalization of MMP-1 and MMP-2 was seen within the cells following treatment with monensin.	Monensin	89-97	matrix metallopeptidase 1	Homo sapiens	22-27
8410828-5	1993	Immunolocalization of MMP-1 and MMP-2 was seen within the cells following treatment with monensin.	Monensin	89-97	matrix metallopeptidase 2	Homo sapiens	32-37
8392648-8	1993	Monensin but not cycloheximide inhibited RGDS restoration of CD16 and CD32w.	Monensin	0-8	Fc gamma receptor IIIa	Homo sapiens	61-65
8426373-7	1993	RESULTS: Liposomal monensin potentiated the cytotoxic action of cell-specific anti-human transferrin receptor immunotoxin on H-MESO-1 target cells at a molar concentration of monensin that was 160-fold lower than the concentration of monensin in buffer that produced the same effect (0.3 nM versus 0.05 microM).	Monensin	19-27	transferrin	Homo sapiens	89-100
8426373-7	1993	RESULTS: Liposomal monensin potentiated the cytotoxic action of cell-specific anti-human transferrin receptor immunotoxin on H-MESO-1 target cells at a molar concentration of monensin that was 160-fold lower than the concentration of monensin in buffer that produced the same effect (0.3 nM versus 0.05 microM).	Monensin	19-27	transcription factor 15	Mus musculus	127-133
8426373-7	1993	RESULTS: Liposomal monensin potentiated the cytotoxic action of cell-specific anti-human transferrin receptor immunotoxin on H-MESO-1 target cells at a molar concentration of monensin that was 160-fold lower than the concentration of monensin in buffer that produced the same effect (0.3 nM versus 0.05 microM).	Monensin	175-183	transferrin	Homo sapiens	89-100
8426373-8	1993	Moreover, immunotoxin plus 0.1 microM liposomal monensin was fivefold more toxic for H-MESO-1 cells and 1000-fold and 2200-fold more toxic for human glioblastoma U373 and U87 cells, respectively, than immunotoxin plus 0.1 microM free monensin in buffer.	Monensin	48-56	transcription factor 15	Mus musculus	87-93
1647205-2	1991	This EIA effect was further synergistically enhanced by lowering intracellular pH (pHi) with either nigericin or sodium propionate, and reversed by raising pHi with monensin or ammonium chloride.	Monensin	165-173	glucose-6-phosphate isomerase	Homo sapiens	156-159
8235310-7	1993	CA 125 was demonstrated to incorporate [3H]-galactose but the level of radioactive incorporation was greatly reduced when WISH cells were incubated in the presence of phenyl N-acetyl-alpha-D-galactosaminide (an inhibitor of O-linked glycosylation) or monensin (an inhibitor of intracellular protein transport within the Golgi complex).	Monensin	251-259	mucin 16, cell surface associated	Homo sapiens	0-6
1627180-4	1992	Insulin-stimulated synthesis of the plasma membrane "signal" ATP in an amount of 1-10 nM is potentized by ionophores carbonyl cyanide p-trifluorometoxyphenylhydrazone and monensin and inhibited by amiloride and ouabain.	Monensin	171-179	insulin	Homo sapiens	0-7
1531639-5	1992	Pulse-chase biosynthetic assays demonstrated that the fate of the unglycosylated CD45 proteins underwent a late non-lysosomal degradation, since it was not prevented either by monensin, an inhibitor of Golgi transport, or by the lysosomal function inhibitor chloroquine.	Monensin	176-184	protein tyrosine phosphatase receptor type C	Homo sapiens	81-85
1684938-0	1991	Decrease of mRNA levels and biosynthesis of sucrase-isomaltase but not dipeptidylpeptidase IV in forskolin or monensin-treated Caco-2 cells.	Monensin	110-118	sucrase-isomaltase	Homo sapiens	44-62
1655501-4	1991	The effect of 1 microM VIP was mimicked by 10 microM dibutyryl cyclic AMP and attenuated by dopamine (1 x 10(-4) M), while colchicine, beta-lumicolchicine, and monensin, all at 1 microM, had no effect.	Monensin	160-168	vasoactive intestinal peptide	Gallus gallus	23-26
1443100-6	1992	EIPA at 10 microM inhibited the Na+ influx, the rise in pHi, and intra- and extracellular IL-1 beta production in activated monocytes; this inhibition was reversed by 10 nM monensin.	Monensin	173-181	glucose-6-phosphate isomerase	Homo sapiens	56-59
1443100-6	1992	EIPA at 10 microM inhibited the Na+ influx, the rise in pHi, and intra- and extracellular IL-1 beta production in activated monocytes; this inhibition was reversed by 10 nM monensin.	Monensin	173-181	interleukin 1 beta	Homo sapiens	90-99
1527011-7	1992	Lysosomotropic agents, such as NH4Cl, chloroquine, and monensin inhibited CD4 degradation, consistent with a lysosomal fate for CD4.	Monensin	55-63	CD4 molecule	Homo sapiens	74-77
1868454-3	1991	Monensin in emulsion or in buffer was equally effective for the in vitro potentiation of the cytotoxicity of both anti-human transferrin receptor and anti-carcinoembryonic antigen immunotoxins against target cells.	Monensin	0-8	transferrin	Mus musculus	125-136
1716879-4	1991	Isoproterenol-dependent ornithine decarboxylase induction and phosphorylation of the proteins were selectively suppressed by monensin but not by polymyxin B, whereas carbachol-dependent ornithine decarboxylase induction and protein phosphorylation were inhibited by polymyxin B but not by monensin.	Monensin	125-133	ornithine decarboxylase 1	Rattus norvegicus	24-47
1705556-5	1991	The epitopes are protein and not carbohydrate as both monoclonals were able to precipitate deglycosylated CD13 from tunicamycin- and monensin-treated cells and o-glycanase-treated purified CD13.	Monensin	133-141	alanyl aminopeptidase, membrane	Homo sapiens	106-110
2242730-2	1990	Monensin was seen to cause a slight depression in the amount of cytochrome P-450 and cytochrome b5 as well as in the activities of aniline-p-hydroxylase, p-nitrophenol-hydroxylase and p-nitroanisole-O-demethylase.	Monensin	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-98
1920277-6	1991	In contrast, the surface expression of both insulin and IGF-II binding sites (classical and atypical insulin receptors) increased 1.3 to 1.7-fold after treatment with dexamethasone (200 nM) and decreased 30 to 45% after monensin (1 microM).	Monensin	220-228	insulin	Homo sapiens	44-51
1920277-6	1991	In contrast, the surface expression of both insulin and IGF-II binding sites (classical and atypical insulin receptors) increased 1.3 to 1.7-fold after treatment with dexamethasone (200 nM) and decreased 30 to 45% after monensin (1 microM).	Monensin	220-228	insulin like growth factor 2	Homo sapiens	56-62
1920277-6	1991	In contrast, the surface expression of both insulin and IGF-II binding sites (classical and atypical insulin receptors) increased 1.3 to 1.7-fold after treatment with dexamethasone (200 nM) and decreased 30 to 45% after monensin (1 microM).	Monensin	220-228	insulin	Homo sapiens	101-108
2147429-4	1990	The phagosome to cytosol pH gradient could be collapsed by addition of nigericin, monensin, or weak bases.	Monensin	82-90	phosphohistidine phosphatase 1	Mus musculus	25-27
2268269-1	1990	Rapid and parallel secretion of lysosomal beta-N-acetylglucosaminidase and preloaded fluorescein-labelled dextran was initiated in macrophages by agents affecting intracellular pH (methylamine, chlorpromazine, and the ionophores monensin and nigericin).	Monensin	229-237	O-GlcNAcase	Homo sapiens	42-70
2387330-4	1990	Monensin (50 microM), an inhibitor of endocytotic trafficking, reduced the rate of transport of 125I-A-II.	Monensin	0-8	angiotensinogen	Homo sapiens	101-105
1848562-8	1991	Proteolytic cleavage of mature TGF-beta 2 from pro-TGF-beta 2 was inhibited by monensin and chloroquine suggesting that binding to this receptor and subsequent transport to acidic vesicles may be involved in the processing of rTGF-beta 2 precursor.	Monensin	79-87	transforming growth factor, beta 2	Rattus norvegicus	31-41
1848562-8	1991	Proteolytic cleavage of mature TGF-beta 2 from pro-TGF-beta 2 was inhibited by monensin and chloroquine suggesting that binding to this receptor and subsequent transport to acidic vesicles may be involved in the processing of rTGF-beta 2 precursor.	Monensin	79-87	transforming growth factor, beta 2	Rattus norvegicus	51-61
1848562-8	1991	Proteolytic cleavage of mature TGF-beta 2 from pro-TGF-beta 2 was inhibited by monensin and chloroquine suggesting that binding to this receptor and subsequent transport to acidic vesicles may be involved in the processing of rTGF-beta 2 precursor.	Monensin	79-87	transforming growth factor, beta 2	Rattus norvegicus	226-237
2328723-6	1990	Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.	Monensin	211-219	interleukin 1 beta	Homo sapiens	13-22
2298725-12	1990	However, our results indicate that monensin-induced transmodulation of the EGF receptor occurs with or without external sodium, suggesting that the loss of binding is not the result of a sodium ion influx.	Monensin	35-43	epidermal growth factor	Mus musculus	75-78
2160828-2	1990	In initial studies to characterize Na+/H+ exchange in FRTL-5 cell suspensions, the recovery of a resting pHi in acid-loaded cells was shown to be dependent upon the presence of extracellular Na+, was enhanced by the presence of the sodium ionophore monensin and was abolished by amiloride, an antagonist of Na+/H+ antiport activity.	Monensin	249-257	glucose-6-phosphate isomerase	Rattus norvegicus	105-108
2384978-8	1990	Ammonium chloride and monensin, inhibitors of lysosomal enzymes, enhanced the cytotoxicity of T-2-mAb.	Monensin	22-30	brachyury 2	Mus musculus	94-97
2295813-8	1990	C5a receptor reexpression was completely blocked by monensin suggesting receptor recycling, whereas monensin had little effect on FMLPL receptor reexpression.	Monensin	52-60	complement C5a receptor 1	Homo sapiens	0-12
34271220-8	2021	Rapid intracellular accumulation of GCG-stimulated GCGR in cells lacking WASH complex or in the presence of monensin indicates that activated GCGRs undergo continuous cycles of internalisation and recycling despite apparent GCGR plasma membrane localisation up to 40 minutes post-stimulation.	Monensin	108-116	glucagon	Homo sapiens	36-39
2153112-8	1990	This inhibition could be completely overcome by artificially raising pHi using either NH4Cl or the Na+/H+ ionophore monensin.	Monensin	116-124	glucose-6-phosphate isomerase	Homo sapiens	69-72
33803345-2	2021	Treatment with brefeldin A (BFA) and monensin induced the cleavage of full-length CREB3 and CREB3L2; however, the level of the full-length CREB3 protein, but not CREB3L2 protein, was not noticeably reduced by the monensin treatment.	Monensin	37-45	cAMP responsive element binding protein 3	Homo sapiens	82-87
33803345-2	2021	Treatment with brefeldin A (BFA) and monensin induced the cleavage of full-length CREB3 and CREB3L2; however, the level of the full-length CREB3 protein, but not CREB3L2 protein, was not noticeably reduced by the monensin treatment.	Monensin	37-45	cAMP responsive element binding protein 3 like 2	Homo sapiens	92-99
33803345-2	2021	Treatment with brefeldin A (BFA) and monensin induced the cleavage of full-length CREB3 and CREB3L2; however, the level of the full-length CREB3 protein, but not CREB3L2 protein, was not noticeably reduced by the monensin treatment.	Monensin	37-45	cAMP responsive element binding protein 3	Homo sapiens	92-97
34271220-8	2021	Rapid intracellular accumulation of GCG-stimulated GCGR in cells lacking WASH complex or in the presence of monensin indicates that activated GCGRs undergo continuous cycles of internalisation and recycling despite apparent GCGR plasma membrane localisation up to 40 minutes post-stimulation.	Monensin	108-116	glucagon receptor	Mus musculus	51-55