PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11129014-4	2000	Accordingly, preclinical studies to evaluate the use of valrubicin, a contact-safe, mechanistically novel antitumor agent, combined with low-dose radiation for the therapy of SCC have been conducted.	valrubicin	56-66	serpin family B member 3	Homo sapiens	175-178
11129014-11	2000	This effect appears to correlate with the ability of valrubicin, a cytoplasmic-localizing drug, to inhibit protein kinase C. Therapeutic use of valrubicin against SCC could provide for reduced radiation doses with consequent improved efficacy and reduction in host toxicity.	valrubicin	53-63	serpin family B member 3	Homo sapiens	163-166
11129014-11	2000	This effect appears to correlate with the ability of valrubicin, a cytoplasmic-localizing drug, to inhibit protein kinase C. Therapeutic use of valrubicin against SCC could provide for reduced radiation doses with consequent improved efficacy and reduction in host toxicity.	valrubicin	144-154	serpin family B member 3	Homo sapiens	163-166
3756902-0	1986	Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine.	valrubicin	29-68	calmodulin 2	Mus musculus	174-184
3756902-5	1986	In cells treated continuously for 24 h with ADR (0.01-0.05 micrograms/ml) or the DNA nonbinding ADR analogue N-trifluoro-acetyladriamycin-14-valerate (AD32) (0.05 and 0.1 micrograms/ml) the survival in soft agar was 3- to 20-fold higher in the presence versus the absence of 2 mM CAF.	valrubicin	109-149	caffeine susceptibility	Mus musculus	280-283
24085052-3	2013	Valrubicin localizes in the cytoplasm and its valerate moiety resembles diacylglycerol, an activator of protein kinase C (PKC) alpha, which belongs to the PKC family of cytoplasmic serine/threonine protein kinases.	valrubicin	0-10	protein kinase C alpha	Homo sapiens	104-132
24085052-3	2013	Valrubicin localizes in the cytoplasm and its valerate moiety resembles diacylglycerol, an activator of protein kinase C (PKC) alpha, which belongs to the PKC family of cytoplasmic serine/threonine protein kinases.	valrubicin	0-10	protein kinase C alpha	Homo sapiens	122-125
24085052-7	2013	METHODS: PKCalpha"s characteristic to translocate from the cytoplasm to the cellular membrane when activated was assessed by measuring the amount of PKCalpha in the soluble and membrane-bound protein fractions isolated from valrubicin stimulated keratinocytes and by visualizing PKCalpha in stimulated cells over time.	valrubicin	224-234	protein kinase C alpha	Homo sapiens	9-17
24085052-7	2013	METHODS: PKCalpha"s characteristic to translocate from the cytoplasm to the cellular membrane when activated was assessed by measuring the amount of PKCalpha in the soluble and membrane-bound protein fractions isolated from valrubicin stimulated keratinocytes and by visualizing PKCalpha in stimulated cells over time.	valrubicin	224-234	protein kinase C alpha	Homo sapiens	149-157
24085052-7	2013	METHODS: PKCalpha"s characteristic to translocate from the cytoplasm to the cellular membrane when activated was assessed by measuring the amount of PKCalpha in the soluble and membrane-bound protein fractions isolated from valrubicin stimulated keratinocytes and by visualizing PKCalpha in stimulated cells over time.	valrubicin	224-234	protein kinase C alpha	Homo sapiens	149-157
24085052-8	2013	Downstream signaling was investigated by measuring the amount of phosphorylated Myristoylated Alanine-rich C-kinase substrate (MARCKS) and extracellular signal-regulated kinases (ERK) 1/2 of valrubicin-stimulated keratinocytes.	valrubicin	191-201	myristoylated alanine rich protein kinase C substrate	Homo sapiens	127-133
24085052-10	2013	RESULTS: Valrubicin activates PKCalpha in vitro as shown by PKCalpha"s translocation and phosphorylation of downstream signaling molecules.	valrubicin	9-19	protein kinase C alpha	Homo sapiens	30-38
24085052-10	2013	RESULTS: Valrubicin activates PKCalpha in vitro as shown by PKCalpha"s translocation and phosphorylation of downstream signaling molecules.	valrubicin	9-19	protein kinase C alpha	Homo sapiens	60-68